Cluster-1074.0-0F CMGC_MAPK 89 373 4 288 IKPIGRGAYGIVCSSINRETNERVAIKKISNVFGNQIDALRTLRELVLLRNIKHKNVIALKDVMMPVHIRSFNDVYLVYELMDTDLHQIIKSRQIISNDHCRYFIFQILCGLEYLHSANILHRDLKPGNLLINLNCELKICDFGLARTSKEKGQYMTEYVVTRWYRAPELLLSCDNYGTSIDVWSVGCILAEILGGKPIFPGTNSLSQIELIMSVLGEQHEEDLKFIDNEKAKRFIRSSKFFTGRPFSALYPHADPLAIDLLQRMLVFDPSQRITVAEALRHPYI +++iG+G+yg+vcs++++et+e+vaikki++vf n+ida r+lre+ llr+++h+n+++lkdv++p + ++f+Dvy+v+elmdtdlhq+iks++ ++++h++y+++q+l gl+ylhsan+lhrDlkp+nll+n nc+lkicDfGlar+++++ +++teyvvtrwyraPellls+++Y+++iDvWsvGCi+ae+l +kp+fpg++ ++q++li++++G+++eedl+++++eka+r++++ + +++++++++p++d+la+dLl+r+l+fdP++rit+ eal+hpy+ eeviGkGsygvvcsavdtetgekvaikkiedvfenlidakrvlreikllrrlehenivelkdvlkpaekeefkDvyivlelmdtdlhqviksndelteehvqyllyqllrglkylhsanvlhrDlkpknlllnancklkicDfGlarsassetdllteyvvtrwyraPelllssskYtsaiDvWsvGCifaelltrkplfpgkdvvdqlkliteliGtpseedlesvrsekarrylkklpkkakkslkkkfpkvdelaldLlerllafdPkkritaeealahpyl 436.5 3.2e-133 CMGC_MAPK 487 Cluster-1074.0-0F PF00069.22 89 373 4 264 IKPIGRGAYGIVCSSINRETNERVAIKKISNVFGNQIDALRTLRELVLLRNIKHKNVIALKDVMMPvhirsFNDVYLVYELMDTD-LHQIIKSRQIISNDHCRYFIFQILCGLEYLHSANILHRDLKPGNLLINLNCELKICDFGLARTSKEKGQyMTEYVVTRWYRAPELLlSCDNYGTSIDVWSVGCILAEILGGKPIFP---GTN----SLSQIELIMSVLGeqhE--EDLKFIDNEkakrfirsskfftgrpfsalyphaDPLAIDLLQRMLVFDPSQRITVAEALRHPYI ++ +G+G++G V + +++et++ vA+Kki++ ++ + ++lrE+ +l+++kh+n++ l++v+ +++ylv e+++++ l+++++ ++++s+++++ ++ qil gleylHs++i+HrDlKp N+Li+ + elKi+DFGla+ +++ + +t++v+tr+Y+APE+l + +y++++DvWs+G+il+e+l gkp+f+ g++ l q+e i+ +lg e e+l+ ++ ++ a+dll+++l dp++R+t++e+l+hpy+ leklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee.....kdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk.ltsfvgtreYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg...etkeklpeasel........................seeakdllkkllkkdpkkRltaeellqhpyl 237.9 8.1e-73 Protein kinase domain 487 Cluster-1074.0-0F PF07714.14 90 296 5 215 KPIGRGAYGIVCSSINR----ETNERVAIKKISNVFGNQiDALRTLRELVLLRNIKHKNVIALKDVMMpvhirSFNDVYLVYELMDT-DLHQIIKSR---QIISNDHCRYFIFQILCGLEYLHSANILHRDLKPGNLLINLNCELKICDFGLARTSKEKGQYM---TEYVVTRWYrAPELLLSCDnYGTSIDVWSVGCILAEILG-GKPIFPGTNSLSQ k +G+Ga+G V++ + + +++ +va+K++++ ++ + + l+e+ +++++kh+n+++l v++ + + +++v e+++ dL++ ++++ + ++ ++ f++qi +G+eyL+s +++Hrdl N L++ n ki+DfGLar+ +++ +y ++ + +W+ apE l ++ + ++ DvWs G +l Ei+ g+ +pg ++ + kklGeGafGeVvegtlkgekekkevkvavKtlkeeatee.ekeefleeakimkklkhpnivkllgvct.....keepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWm.apEslkekk.ftsksDvWsfGvllwEiftlgeepypglsneev 114.0 4.7e-35 Protein tyrosine kinase 487 Cluster-1074.1-0F CMGC_MAPK 118 402 4 288 IKPIGRGAYGIVCSSINRETNERVAIKKISNVFGNQIDALRTLRELVLLRNIKHKNVIALKDVMMPVHIRSFNDVYLVYELMDTDLHQIIKSRQIISNDHCRYFIFQILCGLEYLHSANILHRDLKPGNLLINLNCELKICDFGLARTSKEKGQYMTEYVVTRWYRAPELLLSCDNYGTSIDVWSVGCILAEILGGKPIFPGTNSLSQIELIMSVLGEQHEEDLKFIDNEKAKRFIRSSKFFTGRPFSALYPHADPLAIDLLQRMLVFDPSQRITVAEALRHPYI +++iG+G+yg+vcs++++et+e+vaikki++vf n+ida r+lre+ llr+++h+n+++lkdv++p + ++f+Dvy+v+elmdtdlhq+iks++ ++++h++y+++q+l gl+ylhsan+lhrDlkp+nll+n nc+lkicDfGlar+++++ +++teyvvtrwyraPellls+++Y+++iDvWsvGCi+ae+l +kp+fpg++ ++q++li++++G+++eedl+++++eka+r++++ + +++++++++p++d+la+dLl+r+l+fdP++rit+ eal+hpy+ eeviGkGsygvvcsavdtetgekvaikkiedvfenlidakrvlreikllrrlehenivelkdvlkpaekeefkDvyivlelmdtdlhqviksndelteehvqyllyqllrglkylhsanvlhrDlkpknlllnancklkicDfGlarsassetdllteyvvtrwyraPelllssskYtsaiDvWsvGCifaelltrkplfpgkdvvdqlkliteliGtpseedlesvrsekarrylkklpkkakkslkkkfpkvdelaldLlerllafdPkkritaeealahpyl 436.3 3.8e-133 CMGC_MAPK 516 Cluster-1074.1-0F PF00069.22 118 402 4 264 IKPIGRGAYGIVCSSINRETNERVAIKKISNVFGNQIDALRTLRELVLLRNIKHKNVIALKDVMMPvhirsFNDVYLVYELMDTD-LHQIIKSRQIISNDHCRYFIFQILCGLEYLHSANILHRDLKPGNLLINLNCELKICDFGLARTSKEKGQyMTEYVVTRWYRAPELLlSCDNYGTSIDVWSVGCILAEILGGKPIFP---GTN----SLSQIELIMSVLGeqhE--EDLKFIDNEkakrfirsskfftgrpfsalyphaDPLAIDLLQRMLVFDPSQRITVAEALRHPYI ++ +G+G++G V + +++et++ vA+Kki++ ++ + ++lrE+ +l+++kh+n++ l++v+ +++ylv e+++++ l+++++ ++++s+++++ ++ qil gleylHs++i+HrDlKp N+Li+ + elKi+DFGla+ +++ + +t++v+tr+Y+APE+l + +y++++DvWs+G+il+e+l gkp+f+ g++ l q+e i+ +lg e e+l+ ++ ++ a+dll+++l dp++R+t++e+l+hpy+ leklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee.....kdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk.ltsfvgtreYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg...etkeklpeasel........................seeakdllkkllkkdpkkRltaeellqhpyl 237.7 9.5e-73 Protein kinase domain 516 Cluster-1074.1-0F PF07714.14 119 325 5 215 KPIGRGAYGIVCSSINR----ETNERVAIKKISNVFGNQiDALRTLRELVLLRNIKHKNVIALKDVMMpvhirSFNDVYLVYELMDT-DLHQIIKSR---QIISNDHCRYFIFQILCGLEYLHSANILHRDLKPGNLLINLNCELKICDFGLARTSKEKGQYM---TEYVVTRWYrAPELLLSCDnYGTSIDVWSVGCILAEILG-GKPIFPGTNSLSQ k +G+Ga+G V++ + + +++ +va+K++++ ++ + + l+e+ +++++kh+n+++l v++ + + +++v e+++ dL++ ++++ + ++ ++ f++qi +G+eyL+s +++Hrdl N L++ n ki+DfGLar+ +++ +y ++ + +W+ apE l ++ + ++ DvWs G +l Ei+ g+ +pg ++ + kklGeGafGeVvegtlkgekekkevkvavKtlkeeatee.ekeefleeakimkklkhpnivkllgvct.....keepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWm.apEslkekk.ftsksDvWsfGvllwEiftlgeepypglsneev 113.8 5.4e-35 Protein tyrosine kinase 516 Cluster-1074.2-0F CMGC_MAPK 122 406 4 288 IKPIGRGAYGIVCSSINRETNERVAIKKISNVFGNQIDALRTLRELVLLRNIKHKNVIALKDVMMPVHIRSFNDVYLVYELMDTDLHQIIKSRQIISNDHCRYFIFQILCGLEYLHSANILHRDLKPGNLLINLNCELKICDFGLARTSKEKGQYMTEYVVTRWYRAPELLLSCDNYGTSIDVWSVGCILAEILGGKPIFPGTNSLSQIELIMSVLGEQHEEDLKFIDNEKAKRFIRSSKFFTGRPFSALYPHADPLAIDLLQRMLVFDPSQRITVAEALRHPYI +++iG+G+yg+vcs++++et+e+vaikki++vf n+ida r+lre+ llr+++h+n+++lkdv++p + ++f+Dvy+v+elmdtdlhq+iks++ ++++h++y+++q+l gl+ylhsan+lhrDlkp+nll+n nc+lkicDfGlar+++++ +++teyvvtrwyraPellls+++Y+++iDvWsvGCi+ae+l +kp+fpg++ ++q++li++++G+++eedl+++++eka+r++++ + +++++++++p++d+la+dLl+r+l+fdP++rit+ eal+hpy+ eeviGkGsygvvcsavdtetgekvaikkiedvfenlidakrvlreikllrrlehenivelkdvlkpaekeefkDvyivlelmdtdlhqviksndelteehvqyllyqllrglkylhsanvlhrDlkpknlllnancklkicDfGlarsassetdllteyvvtrwyraPelllssskYtsaiDvWsvGCifaelltrkplfpgkdvvdqlkliteliGtpseedlesvrsekarrylkklpkkakkslkkkfpkvdelaldLlerllafdPkkritaeealahpyl 436.2 3.9e-133 CMGC_MAPK 520 Cluster-1074.2-0F PF00069.22 122 406 4 264 IKPIGRGAYGIVCSSINRETNERVAIKKISNVFGNQIDALRTLRELVLLRNIKHKNVIALKDVMMPvhirsFNDVYLVYELMDTD-LHQIIKSRQIISNDHCRYFIFQILCGLEYLHSANILHRDLKPGNLLINLNCELKICDFGLARTSKEKGQyMTEYVVTRWYRAPELLlSCDNYGTSIDVWSVGCILAEILGGKPIFP---GTN----SLSQIELIMSVLGeqhE--EDLKFIDNEkakrfirsskfftgrpfsalyphaDPLAIDLLQRMLVFDPSQRITVAEALRHPYI ++ +G+G++G V + +++et++ vA+Kki++ ++ + ++lrE+ +l+++kh+n++ l++v+ +++ylv e+++++ l+++++ ++++s+++++ ++ qil gleylHs++i+HrDlKp N+Li+ + elKi+DFGla+ +++ + +t++v+tr+Y+APE+l + +y++++DvWs+G+il+e+l gkp+f+ g++ l q+e i+ +lg e e+l+ ++ ++ a+dll+++l dp++R+t++e+l+hpy+ leklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee.....kdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk.ltsfvgtreYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg...etkeklpeasel........................seeakdllkkllkkdpkkRltaeellqhpyl 237.6 9.7e-73 Protein kinase domain 520 Cluster-1074.2-0F PF07714.14 123 329 5 215 KPIGRGAYGIVCSSINR----ETNERVAIKKISNVFGNQiDALRTLRELVLLRNIKHKNVIALKDVMMpvhirSFNDVYLVYELMDT-DLHQIIKSR---QIISNDHCRYFIFQILCGLEYLHSANILHRDLKPGNLLINLNCELKICDFGLARTSKEKGQYM---TEYVVTRWYrAPELLLSCDnYGTSIDVWSVGCILAEILG-GKPIFPGTNSLSQ k +G+Ga+G V++ + + +++ +va+K++++ ++ + + l+e+ +++++kh+n+++l v++ + + +++v e+++ dL++ ++++ + ++ ++ f++qi +G+eyL+s +++Hrdl N L++ n ki+DfGLar+ +++ +y ++ + +W+ apE l ++ + ++ DvWs G +l Ei+ g+ +pg ++ + kklGeGafGeVvegtlkgekekkevkvavKtlkeeatee.ekeefleeakimkklkhpnivkllgvct.....keepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWm.apEslkekk.ftsksDvWsfGvllwEiftlgeepypglsneev 113.8 5.5e-35 Protein tyrosine kinase 520 Cluster-1074.3-0F CMGC_MAPK 76 360 4 288 IKPIGRGAYGIVCSSINRETNERVAIKKISNVFGNQIDALRTLRELVLLRNIKHKNVIALKDVMMPVHIRSFNDVYLVYELMDTDLHQIIKSRQIISNDHCRYFIFQILCGLEYLHSANILHRDLKPGNLLINLNCELKICDFGLARTSKEKGQYMTEYVVTRWYRAPELLLSCDNYGTSIDVWSVGCILAEILGGKPIFPGTNSLSQIELIMSVLGEQHEEDLKFIDNEKAKRFIRSSKFFTGRPFSALYPHADPLAIDLLQRMLVFDPSQRITVAEALRHPYI +++iG+G+yg+vcs++++et+e+vaikki++vf n+ida r+lre+ llr+++h+n+++lkdv++p + ++f+Dvy+v+elmdtdlhq+iks++ ++++h++y+++q+l gl+ylhsan+lhrDlkp+nll+n nc+lkicDfGlar+++++ +++teyvvtrwyraPellls+++Y+++iDvWsvGCi+ae+l +kp+fpg++ ++q++li++++G+++eedl+++++eka+r++++ + +++++++++p++d+la+dLl+r+l+fdP++rit+ eal+hpy+ eeviGkGsygvvcsavdtetgekvaikkiedvfenlidakrvlreikllrrlehenivelkdvlkpaekeefkDvyivlelmdtdlhqviksndelteehvqyllyqllrglkylhsanvlhrDlkpknlllnancklkicDfGlarsassetdllteyvvtrwyraPelllssskYtsaiDvWsvGCifaelltrkplfpgkdvvdqlkliteliGtpseedlesvrsekarrylkklpkkakkslkkkfpkvdelaldLlerllafdPkkritaeealahpyl 436.6 3e-133 CMGC_MAPK 474 Cluster-1074.3-0F PF00069.22 76 360 4 264 IKPIGRGAYGIVCSSINRETNERVAIKKISNVFGNQIDALRTLRELVLLRNIKHKNVIALKDVMMPvhirsFNDVYLVYELMDTD-LHQIIKSRQIISNDHCRYFIFQILCGLEYLHSANILHRDLKPGNLLINLNCELKICDFGLARTSKEKGQyMTEYVVTRWYRAPELLlSCDNYGTSIDVWSVGCILAEILGGKPIFP---GTN----SLSQIELIMSVLGeqhE--EDLKFIDNEkakrfirsskfftgrpfsalyphaDPLAIDLLQRMLVFDPSQRITVAEALRHPYI ++ +G+G++G V + +++et++ vA+Kki++ ++ + ++lrE+ +l+++kh+n++ l++v+ +++ylv e+++++ l+++++ ++++s+++++ ++ qil gleylHs++i+HrDlKp N+Li+ + elKi+DFGla+ +++ + +t++v+tr+Y+APE+l + +y++++DvWs+G+il+e+l gkp+f+ g++ l q+e i+ +lg e e+l+ ++ ++ a+dll+++l dp++R+t++e+l+hpy+ leklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee.....kdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk.ltsfvgtreYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg...etkeklpeasel........................seeakdllkkllkkdpkkRltaeellqhpyl 238.0 7.5e-73 Protein kinase domain 474 Cluster-1074.3-0F PF07714.14 77 283 5 215 KPIGRGAYGIVCSSINR----ETNERVAIKKISNVFGNQiDALRTLRELVLLRNIKHKNVIALKDVMMpvhirSFNDVYLVYELMDT-DLHQIIKSR---QIISNDHCRYFIFQILCGLEYLHSANILHRDLKPGNLLINLNCELKICDFGLARTSKEKGQYM---TEYVVTRWYrAPELLLSCDnYGTSIDVWSVGCILAEILG-GKPIFPGTNSLSQ k +G+Ga+G V++ + + +++ +va+K++++ ++ + + l+e+ +++++kh+n+++l v++ + + +++v e+++ dL++ ++++ + ++ ++ f++qi +G+eyL+s +++Hrdl N L++ n ki+DfGLar+ +++ +y ++ + +W+ apE l ++ + ++ DvWs G +l Ei+ g+ +pg ++ + kklGeGafGeVvegtlkgekekkevkvavKtlkeeatee.ekeefleeakimkklkhpnivkllgvct.....keepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWm.apEslkekk.ftsksDvWsfGvllwEiftlgeepypglsneev 114.1 4.4e-35 Protein tyrosine kinase 474 Cluster-1086.0-1F STE_STE11 18 277 2 255 RGEKLGNGSFGTVNLAIIRNRScqipPLMAVKSCGLSVSDS-LMKEKLILDELkDCPEIIRCFGENFTHENGEkLYNVLLEYASGGALADKVKSCRNNgLPESEVRRHTKALLKGLDYIHKFGYVHCDIKLQNILLGPNGGVKIADFGLAKRVGKEKMAdFGCELRGTPMYMSPEMATGKDQGPPSDIWALGCMVAEMVGGAPPWRL-SGVAELLMRIGVRGEAPEMPSNLSSEGKDFLEKCFVNDPSKRWTAEMLLNHPFV +ge lG+g+fg+V+la+ ++ l+avks+ l+ ++s L+kE +l++L ++p+i+r++g+++++e++e +n+llEy+sgg la+ +k++ ++ l+es+vr++t+ +l+GL+y+H+ g+vH+Dik +Nil+ ng vk+aDFGlak+v++e+++ +++gtp+ym+pe++ ++++g+ +Diw+lGC+V em+ g++pw + + l++ig +e+Pe+p++ls+e+kdFl+kC+ dp++R+ta++LL+hpF+ kgellGegafgsVylalnkesg....ellavksvelesaksaLekEikllskL.khpnivrylgseveeekse.elnillEyvsggslasllkrlggk.lseslvrkytrqileGLeylHskgivHrDikgaNilvdsngevklaDFGlakeveeeesl.asksvkgtplymapevirkeelglaaDiwslGCtVlemltgkapwseleeevaalfkigkskelPeipeslseeakdFlskClqrdpaeRptaaeLLehpFl 288.6 3.6e-88 STE_STE11 378 Cluster-1086.0-1F PF00069.22 18 277 3 264 RGEKLGNGSFGTVNLAIIRNRSCQipplMAVKSCGLSVSDS-----LMKEKLILDELKdCPEIIRCFGENFThenGEKLYnVLLEYASGGALADKVKscRNNGLPESEVRRHTKALLKGLDYIHKFGYVHCDIKLQNILLGPNGGVKIADFGLAKRVGKEKMadfGCELRGTPMYMSPEMATGKDQGPPSDIWALGCMVAEMVGGAPPWRL--------SGVAELLM---RIGVRGEAPEMPSNLSSEGKDFLEKCFVNDPSKRWTAEMLLNHPFV + eklG+GsfG+V a+ ++++++ +AvK + ++ +++E il +lk +p+i+r+++ + ++ly ++ley++gg lad ++ r+ l+e+e+++ +k +l+gl+y+H+ g +H+D+K +NiL+ +g +Ki+DFGlak++ +++ + gt+ Y++PE+ ++++ ++++D+W+lG++++e++ g pp++ + + +l + +g e+ + +s+ls+e kd+l+k++ dp+kR+tae+ll+hp++ kleklGeGsfGkVykaveketgki....vAvKkikkekakkkkekkvlrEikilkklk.hpnivrlyevfee...kdely.lvleyveggeladlls..rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 181.1 1.7e-55 Protein kinase domain 378 Cluster-1086.0-1F PF07714.14 19 272 4 257 GEKLGNGSFGTVNLAIIRNRSCQIPPLMAVKSCGLSVS----DSLMKEKLILDELkDCPEIIRCFGENFtheNGEKlYNVLLEYASGGALADKVKSC-RNNGLPESEVRRHTKALLKGLDYIHKFGYVHCDIKLQNILLGPNGGVKIADFGLAKRVGKEKMADFGCELRGTPMYMSPEMATGKDQGPPSDIWALGCMVAEMVG-GAPPWRLSGVAELLMRIgVRGEAPEMPSNLSSEGKDFLEKCFVNDPSKRWTAEMLL g+klG+G+fG+V +++++++ + avK++ + + +++++e i+ +l + p+i+++ g ++e+ + +++ey++gG L + +++ +++ l +++ + ++ + kG++y+++ +vH d+ +N+Ll n vki+DfGLa+++ k++ e + +m+pE+ + k sD+W+ G ++ E++ g+ p++ +e+l ++ +g+ e+p++ ++e ++++++C+ +dp++R t + l+ gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkkl.khpnivkllgvct...keep.llivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevlekl.kegkrlekpekcpeelyelmkqCweedpeeRptfkelv 115.3 1.8e-35 Protein tyrosine kinase 378 Cluster-1090.0-2F Group-Pl-3 66 260 3 197 RSKLGESSLATVWEAENRTTRQVVALKQIHVTKLTRRLKNCLECELTFLSSVNHPNIIRLLDVIEVEGCIILVLEFCAGGNLASYIRRHGRVQECIARRFIQQLGAGLEVLRSHNVIHRDLKPENILLSSCECNPVLKITDFGLSRILRPDEFAETVCGSPQYMAPEVLQFQRYDEKVDMWSVGAILFELLNGCP ++g s+a+vw+a++++t + va+k+i++++l ++l+++le+e+++l++++hpniirlld+ie e+ i lvle+c+GG+la+yi+r+g+v+e +a++f++ql+aGl+vlr++n+ihrdlkP+n+lls+ + + vlki+dfg++r l+p+e+aet+cGsp ymaPevlq+q+yd+k+d+Wsvgailf+l++G p teqigsgsfavvwkakhkstgeevavkeialerlnkklresleseiailrridhpniirlldlieeedkiylvleyceGGdlaayiqrkgkveeavakkflrqlaaGlkvlrenniihrdlkPqnlllstnddeavlkiadfgfarslqpeelaetlcGsplymaPevlqlqkydakadlWsvgailfqlvtGrp 293.5 8.4e-90 Group-Pl-3 261 Cluster-1090.0-2F PF00069.22 64 260 2 195 VLRSKLGESSLATVWEAENRTTRQVVALKQIHVTKLTRRLKNCLECELTFLSSVNHPNIIRLLDVIEVEGCIILVLEFCAGGNLASYIRRHGRVQECIARRFIQQLGAGLEVLRSHNVIHRDLKPENILLSSCECnpvLKITDFGLSRILRPDEFAETVCGSPQYMAPEVLQFQRYDEKVDMWSVGAILFELLNGCP +klGe s ++V +a +++t++ vA+K+i + k + + ++ + E+++l +++hpni+rl++v+e + ++lvle++ gg+la++++r+g ++e+ a+++++q+ +gle l s+++iHrDlKpeNiL+++ + lKitDFGl++ l+ ++ +++++g+++Y+APEvl+ ++y++kvD+Ws+G il+ell+g+p ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekge...lKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkp 192.6 5.4e-59 Protein kinase domain 261 Cluster-1090.0-2F PF07714.14 65 258 3 202 LRSKLGESSLATVWEAENR----TTRQVVALKQIHVTKLTRRLKNCLEcELTFLSSVNHPNIIRLLDVIEVEGCIILVLEFCAGGNLASYIRRH---GRVQECIARRFIQQLGAGLEVLRSHNVIHRDLKPENILLSScecNPVLKITDFGLSRILRPDEFA---ETVCGSPQYMAPEVLQFQRYDEKVDMWSVGAILFELLNG l +klGe + ++V+e++ + ++++ va+K+++ ++ ++ ++ le e++++++++hpni++ll v+ e+ +++v+e+++gG+L +++r++ +++ +f++q+ +G+e L s++++Hrdl N+Lls+ n v ki+DfGL+r ++ d+ e+ + ++mapE+l+ +++ +k D+Ws G +l+E+++ lgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefle.eakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlse...nkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftl 131.0 3e-40 Protein tyrosine kinase 261 Cluster-1101.1-2R AGC_NDR 225 523 1 257 FELLTMIGKGAFGEVRICREKTTGQVYAMKKLKKSEMLRRGQVEHVKAERNLLAEVDSSCIVKLYCSFQDEEYLYLIMEYLPGGDMMTLLMRKDTLTDYEAKFYVAETVLAIESIHKHNYIHRDIKPDNLLLDRYGHLKLSDFGLCKPLDCSilqedfsvgesfngasrrdersqapkrtrqeqlqhwqknrrmLAYSTVGTPDYIAPEVLLKKGYGMECDWWSLGAIMYEMLVGYPPFYSDDPMSTCRKIVNWRAHLKFPEEAKLSLEAKDLISKLLCNVNQRLGSKGADEIKAHPWF fellt+ig+gafgevr+crek+tg+vyamkklkksemlrrgqvehvkaernllaevds++ivkly+sfqdeeylylimeylpggd+mtllmrkdtlt+ ea+fyvae+vlaiesihkhnyihrdikpdnllld++ghlklsdfglckpld++ laystvgtpdyiapevllkkgygmecdwwslgai+yemlvgyppfysddp++tcrkivnwr++lkfp+eakls eakdlis+llc+v++rlg+kga+eikahpwf felltiigrgafgevrlcrekatgevyamkklkksemlrrgqvehvkaernllaevdselivklyysfqdeeylylimeylpggdlmtllmrkdtltedearfyvaesvlaiesihkhnyihrdikpdnllldkeghlklsdfglckpldak..........................................laystvgtpdyiapevllkkgygmecdwwslgailyemlvgyppfysddplttcrkivnwrtllkfpdeaklskeakdlisrllcdvekrlgtkgaeeikahpwf 545.6 1e-166 AGC_NDR 611 Cluster-1101.1-2R PF00069.22 226 523 2 264 ELLTMIGKGAFGEVRICREKTTGQVYAMKKLKKSEMLRRGQvEHVKAERNLLAEVDSSCIVKLYCSFQDEEYLYLIMEYLPGGDMMTLLMRKDTLTDYEAKFYVAETVLAIESIHKHNYIHRDIKPDNLLLDRYGHLKLSDFGLCKPLDCSILqedfsvgesfngasrrdersqapkrtrqeqlqhwqknrrmlAYSTVGTPDYIAPEVLLKKGYGMECDWWSLGAIMYEMLVGYPPFYSDDPMS----TCRK------IVNwRAHLKFPEEAKLSLEAKDLISKLLC-NVNQRLGskgADEIKAHPWF e l+ +G+G+fG+V ++ek+tg+ +A+Kk+kk+++ + + ++v +E ++l++++++ iv+ly +f+++++lyl++ey++gg++++ll rk +l++ eak+++++++ ++e +H+++ iHrD+Kp+N+L+d+ g+lK++DFGl+k l+ s + s vgt++Y+APEvl +++y+ ++D+WslG i+ye+l g ppf++++ + +++ i++ ++k+pe+ +ls eakdl++kll+ + ++Rl+ a+e+++hp++ ekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk.........................................ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.etkeklpeaselseeakdllkkllkkdpkkRlt...aeellqhpyl 217.2 1.7e-66 Protein kinase domain 611 Cluster-1101.1-2R PF07714.14 226 373 2 154 ELLTMIGKGAFGEVRICREK----TTGQVYAMKKLKKSEMLRRgqVEHVKAERNLLAEVDSSCIVKLYCSFQDEEYLYLIMEYLPGGDMMTLLMRK--DTLTDYEAK-FYVAETVLAIESIHKHNYIHRDIKPDNLLLDRYGHLKLSDFGLCKPL el + +G+GafGeV ++ k ++ + a+K+lk++ + ++ e++ e +++ +++ ivkl+ +ee l++++ey++gGd+ + L +k ++ ++++ + ++++ ++e +++++++Hrd+ N Ll++ + k+sDfGL++ + elgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateee..keefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardi 76.6 1.2e-23 Protein tyrosine kinase 611 Cluster-1101.1-2R PF07714.14 425 491 168 234 GTPDYIAPEVLLKKGYGMECDWWSLGAIMYEMLV-GYPPFYSDDPMSTCRKIvNWRAHLKFPEEAKLS ++apE+l +k + + D Ws G +++E++ g p+ + +++++++k+ + + +l+ pe+++ + lpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevlekl.kegkrlekpekcpee 22.4 4.2e-07 Protein tyrosine kinase 611 Cluster-1101.2-0R AGC_NDR 379 558 120 257 FCYRDIKPDNLLLDRYGHLKLSDFGLCKPLDCSilqedfsvgesfngasrrdersqapkrtrqeqlqhwqknrrmLAYSTVGTPDYIAPEVLLKKGYGMECDWWSLGAIMYEMLVGYPPFYSDDPMSTCRKIVNWRAHLKFPEEAKLSLEAKDLISKLLCNVNQRLGSKGADEIKAHPWF + +rdikpdnllld++ghlklsdfglckpld++ laystvgtpdyiapevllkkgygmecdwwslgai+yemlvgyppfysddp++tcrkivnwr++lkfp+eakls eakdlis+llc+v++rlg+kga+eikahpwf yihrdikpdnllldkeghlklsdfglckpldak..........................................laystvgtpdyiapevllkkgygmecdwwslgailyemlvgyppfysddplttcrkivnwrtllkfpdeaklskeakdlisrllcdvekrlgtkgaeeikahpwf 271.6 4.3e-83 AGC_NDR 819 Cluster-1101.2-0R PF00069.22 379 558 119 264 FCYRDIKPDNLLLDRYGHLKLSDFGLCKPLDCSILqedfsvgesfngasrrdersqapkrtrqeqlqhwqknrrmlAYSTVGTPDYIAPEVLLKKGYGMECDWWSLGAIMYEMLVGYPPFYSDDPMS----TCRK------IVNwRAHLKFPEEAKLSLEAKDLISKLLC-NVNQRLGskgADEIKAHPWF +++rD+Kp+N+L+d+ g+lK++DFGl+k l+ s + s vgt++Y+APEvl +++y+ ++D+WslG i+ye+l g ppf++++ + +++ i++ ++k+pe+ +ls eakdl++kll+ + ++Rl+ a+e+++hp++ iiHrDlKpeNiLidekgelKitDFGlakelesssk.........................................ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.etkeklpeaselseeakdllkkllkkdpkkRlt...aeellqhpyl 103.7 6.8e-32 Protein kinase domain 819 Cluster-1101.2-0R PF07714.14 460 526 168 234 GTPDYIAPEVLLKKGYGMECDWWSLGAIMYEMLV-GYPPFYSDDPMSTCRKIvNWRAHLKFPEEAKLS ++apE+l +k + + D Ws G +++E++ g p+ + +++++++k+ + + +l+ pe+++ + lpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevlekl.kegkrlekpekcpee 21.8 6.3e-07 Protein tyrosine kinase 819 Cluster-1101.2-2R AGC_NDR 225 350 1 126 FELLTMIGKGAFGEVRICREKTTGQVYAMKKLKKSEMLRRGQVEHVKAERNLLAEVDSSCIVKLYCSFQDEEYLYLIMEYLPGGDMMTLLMRKDTLTDYEAKFYVAETVLAIESIHKHNYIHRSVN fellt+ig+gafgevr+crek+tg+vyamkklkksemlrrgqvehvkaernllaevds++ivkly+sfqdeeylylimeylpggd+mtllmrkdtlt+ ea+fyvae+vlaiesihkhnyihr + felltiigrgafgevrlcrekatgevyamkklkksemlrrgqvehvkaernllaevdselivklyysfqdeeylylimeylpggdlmtllmrkdtltedearfyvaesvlaiesihkhnyihrdik 255.8 2.8e-78 AGC_NDR 819 Cluster-1101.2-2R PF00069.22 226 347 2 122 ELLTMIGKGAFGEVRICREKTTGQVYAMKKLKKSEMLRRGQvEHVKAERNLLAEVDSSCIVKLYCSFQDEEYLYLIMEYLPGGDMMTLLMRKDTLTDYEAKFYVAETVLAIESIHKHNYIHR e l+ +G+G+fG+V ++ek+tg+ +A+Kk+kk+++ + + ++v +E ++l++++++ iv+ly +f+++++lyl++ey++gg++++ll rk +l++ eak+++++++ ++e +H+++ iHr ekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHr 95.4 2.4e-29 Protein kinase domain 819 Cluster-1101.2-2R PF07714.14 226 352 2 133 ELLTMIGKGAFGEVRICREK----TTGQVYAMKKLKKSEMLRRgqVEHVKAERNLLAEVDSSCIVKLYCSFQDEEYLYLIMEYLPGGDMMTLLMRK--DTLTDYEAK-FYVAETVLAIESIHKHNYIHRSVNAR el + +G+GafGeV ++ k ++ + a+K+lk++ + ++ e++ e +++ +++ ivkl+ +ee l++++ey++gGd+ + L +k ++ ++++ + ++++ ++e +++++++Hr + ar elgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateee..keefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaar 49.2 2.8e-15 Protein tyrosine kinase 819 Cluster-1101.3-2R AGC_NDR 225 523 1 257 FELLTMIGKGAFGEVRICREKTTGQVYAMKKLKKSEMLRRGQVEHVKAERNLLAEVDSSCIVKLYCSFQDEEYLYLIMEYLPGGDMMTLLMRKDTLTDYEAKFYVAETVLAIESIHKHNYIHRDIKPDNLLLDRYGHLKLSDFGLCKPLDCSilqedfsvgesfngasrrdersqapkrtrqeqlqhwqknrrmLAYSTVGTPDYIAPEVLLKKGYGMECDWWSLGAIMYEMLVGYPPFYSDDPMSTCRKIVNWRAHLKFPEEAKLSLEAKDLISKLLCNVNQRLGSKGADEIKAHPWF fellt+ig+gafgevr+crek+tg+vyamkklkksemlrrgqvehvkaernllaevds++ivkly+sfqdeeylylimeylpggd+mtllmrkdtlt+ ea+fyvae+vlaiesihkhnyihrdikpdnllld++ghlklsdfglckpld++ laystvgtpdyiapevllkkgygmecdwwslgai+yemlvgyppfysddp++tcrkivnwr++lkfp+eakls eakdlis+llc+v++rlg+kga+eikahpwf felltiigrgafgevrlcrekatgevyamkklkksemlrrgqvehvkaernllaevdselivklyysfqdeeylylimeylpggdlmtllmrkdtltedearfyvaesvlaiesihkhnyihrdikpdnllldkeghlklsdfglckpldak..........................................laystvgtpdyiapevllkkgygmecdwwslgailyemlvgyppfysddplttcrkivnwrtllkfpdeaklskeakdlisrllcdvekrlgtkgaeeikahpwf 544.8 1.8e-166 AGC_NDR 784 Cluster-1101.3-2R PF00069.22 226 523 2 264 ELLTMIGKGAFGEVRICREKTTGQVYAMKKLKKSEMLRRGQvEHVKAERNLLAEVDSSCIVKLYCSFQDEEYLYLIMEYLPGGDMMTLLMRKDTLTDYEAKFYVAETVLAIESIHKHNYIHRDIKPDNLLLDRYGHLKLSDFGLCKPLDCSILqedfsvgesfngasrrdersqapkrtrqeqlqhwqknrrmlAYSTVGTPDYIAPEVLLKKGYGMECDWWSLGAIMYEMLVGYPPFYSDDPMS----TCRK------IVNwRAHLKFPEEAKLSLEAKDLISKLLC-NVNQRLGskgADEIKAHPWF e l+ +G+G+fG+V ++ek+tg+ +A+Kk+kk+++ + + ++v +E ++l++++++ iv+ly +f+++++lyl++ey++gg++++ll rk +l++ eak+++++++ ++e +H+++ iHrD+Kp+N+L+d+ g+lK++DFGl+k l+ s + s vgt++Y+APEvl +++y+ ++D+WslG i+ye+l g ppf++++ + +++ i++ ++k+pe+ +ls eakdl++kll+ + ++Rl+ a+e+++hp++ ekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk.........................................ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.etkeklpeaselseeakdllkkllkkdpkkRlt...aeellqhpyl 216.3 3e-66 Protein kinase domain 784 Cluster-1101.3-2R PF07714.14 226 373 2 154 ELLTMIGKGAFGEVRICREK----TTGQVYAMKKLKKSEMLRRgqVEHVKAERNLLAEVDSSCIVKLYCSFQDEEYLYLIMEYLPGGDMMTLLMRK--DTLTDYEAK-FYVAETVLAIESIHKHNYIHRDIKPDNLLLDRYGHLKLSDFGLCKPL el + +G+GafGeV ++ k ++ + a+K+lk++ + ++ e++ e +++ +++ ivkl+ +ee l++++ey++gGd+ + L +k ++ ++++ + ++++ ++e +++++++Hrd+ N Ll++ + k+sDfGL++ + elgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateee..keefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardi 76.0 1.8e-23 Protein tyrosine kinase 784 Cluster-1101.3-2R PF07714.14 425 491 168 234 GTPDYIAPEVLLKKGYGMECDWWSLGAIMYEMLV-GYPPFYSDDPMSTCRKIvNWRAHLKFPEEAKLS ++apE+l +k + + D Ws G +++E++ g p+ + +++++++k+ + + +l+ pe+++ + lpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevlekl.kegkrlekpekcpee 21.9 5.9e-07 Protein tyrosine kinase 784 Cluster-1145.0-0F RLK-Pelle_RLCK-VIIa-2 1 100 177 275 EYVQTGRLTSKSDVWSYGIFLLELITGRRPFDRNRPRSEQKLLEWIRPYLSsDTRKFQQIIDPRLEGKHVLKSAHELSDVANRCLARHRKARPNMSEVLA eyv+tG+lt+ksDv+s+G+ llel+tGrr +d++rp++eqkl++w+rp+ls d+rk+++iiDprleg++ k+a++++ +a++Cl+++ k+Rp+msev++ eyvatGhltaksDvysfGvvllelltGrraldkkrpkeeqklvdwarplls.dkrkleriiDprlegqysakaaqkvaklalkClskepkeRpkmsevve 121.4 3e-37 RLK-Pelle_RLCK-VIIa-2 218 Cluster-1145.0-0F PF07714.14 1 99 176 257 EYVQTGRLTSKSDVWSYGIFLLELIT-GRRPfdrnrprseqkllewirpYLSSDTRKFQQIIDPRLEGKHVLKSAHELSDVANRCLARHRKARPNMSEVL E ++++++tsksDvWs+G+ l E++t g++p y + +++++ + ++ + + ++ k +el ++ ++C++++ + Rp+++e++ EslkekkftsksDvWsfGvllwEiftlgeep..................ypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelv 37.7 8.9e-12 Protein tyrosine kinase 218 Cluster-1145.0-0F PF00069.22 1 100 167 260 EYVQTGRLTSKSDVWSYGIFLLELITGRRPFDRNRPRS--EQKLLE--WIRPYL---SSDTRKFQQIidprlegkhvlksAHELSDVANRCLARHRKARPNMSEVLA E +++ + ++k+DvWs+G+ l+el+tg+ pf ++ ++ e++l + i+ l + ++++ +++ +e+ d+ +++l++ +k R+ ++e+l+ EvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeasel.............seeakdllkkllkkdpkkRltaeellq 36.7 2e-11 Protein kinase domain 218 Cluster-1186.0-2R RLK-Pelle_CR4L 231 373 2 148 NELGRGTYGFVYKAVLPDGRQVAVKRANAATIIHTNSRDFEMELEVLCNVRHSNIVNLLGYCAEMGERLLVYEFMSHGTLHDHLHGG----LSPLNWSLRLKIALQSAKGLEYLHKEVVPPIVHRDVKSSKILLDADWGARIADFDV +++G+g++g vyk++l+dgr+va+kra++a+ ++++++fe Ele+L+++rh+++v+LlGyc+e+ erlLVye+m++g+L+dhLhg +l+W+ R+kial+ a+++eyLh+ +ppi+Hrd+kss iLld++w ar++DF + rkiGkgsfgsvykgrlkdgrevaikraekareskeeeeefenEleiLsklrhkhlvrLlGyceeeeerlLVyeymengsLddhLhgkssssevalsWktRikialgvaraieyLhsyaeppiiHrdikssNiLldsewearlsDFgl 191.1 1.7e-58 RLK-Pelle_CR4L 499 Cluster-1186.0-2R PF07714.14 231 375 5 152 NELGRGTYGFVYKAVLP-----DGRQVAVKRANAaTIIHTNSRDFEMELEVLCNVRHSNIVNLLGYCAEMGERLLVYEFMSHGTLHDHLHGG--LSPLNWSLRLKIALQSAKGLEYLHKEVvppIVHRDVKSSKILLDADWGARIADFDVLT ++lG+G++G V+++ l + +vavK ++ + ++++++f e++++++++h niv+llg c + ++ l+v e++++G+L+++L+ ++l+ + l++alq AkG+eyL+++ +vHrd+ + +Ll+ + ++i+Df + kklGeGafGeVvegtlkgekekkevkvavKtlke.eateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLar 99.5 1.3e-30 Protein tyrosine kinase 499 Cluster-1186.0-2R PF00069.22 228 375 2 146 KEFNELGRGTYGFVYKAV-LPDGRQVAVKRANAATIIHTNSRDFEMELEVLCNVRHSNIVNLLGYCAEMGERLLVYEFMSHGTLHDHLHGGLSpLNWSLRLKIALQSAKGLEYLHKEVvppIVHRDVKSSKILLDADWGARIADFDVLT ++ ++lG+G++G Vykav +g++vAvK+ + + +++ +++ +E+++l +++h+niv+l++++ e e++lv e++++g+l+d+l+ s l+ + kia q ++gleylH++ i+HrD+K++ iL+d + +i+DF++ + ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgs.lseeeakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlak 101.0 4.5e-31 Protein kinase domain 499 Cluster-1207.0-1R RLK-Pelle_RLCK-VIIa-2 2 147 104 249 IRMKVAIGAARGLSFLHEAEEQVIYRDFKASNILLDGDFNAKLSDFGLAKAGPTGDRTHVSTQVMGTQGYAAPEYVATGRLTAKSDVYSFGVVLLELLSGRRALDKSKIGVEQNLVEWAKPYLSDKRRLFRIMDIKLEGQYPQKAA +r+k+a+gaA+gl+fLheae++viyRdfkasniLld dfnaklsdfglak+gp++d+thvst+vmgt+gYaaPeyvatG+ltaksDvysfGvvllell+Grraldk++ eq+lv+wa+p+lsdkr+l ri+D +legqy++kaa trlkialgaAkglafLheaekkviyRdfkasniLldedfnaklsdfglakegpeedkthvstrvmgtygYaaPeyvatGhltaksDvysfGvvllelltGrraldkkrpkeeqklvdwarpllsdkrkleriiDprlegqysakaa 251.9 4.9e-77 RLK-Pelle_RLCK-VIIa-2 149 Cluster-1207.0-1R PF00069.22 9 109 106 203 GAARGLSFLHeaEEQVIYRDFKASNILLDGDFNAKLSDFGLAKAGPTGDRthvSTQVMGTQGYAAPEYVATGRLTAKSDVYSFGVVLLELLSGRRALDKS--K ++gl++lH ++++i+rD K +NiL+d + + K++DFGlak ++ + t+++gt+ Y APE + + + ++k+Dv+s Gv+l+ell+g+ + ++ k qilegleylH..skgiiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgk 89.6 1.4e-27 Protein kinase domain 149 Cluster-1207.0-1R PF07714.14 4 104 107 206 MKVAIGAARGLSFLHEaeEQVIYRDFKASNILLDGDFNAKLSDFGLAKAGPTGDRTHVSTQVMGTQGYAAPEYVATGRLTAKSDVYSFGVVLLELLS-GRRA +++a+ A+G+++L++ ++++ rd a N+Ll+ + +k+sDfGLa++ + d+++++++ + apE + ++++t ksDv+sfGv+l E+++ g++ lsfalqiAkGmeyLes..kklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep 77.3 7.3e-24 Protein tyrosine kinase 149 Cluster-1241.0-1F RLK-Pelle_RLCK-VIIa-2 11 105 181 275 AGHLYVKSDVYGFGVVLLEMLTGLRAVDRKRPLGKQNLVDWVKPLLSQRRKLKSVMDAQMDGQYSSKVLSLVSQLTLICLETEPRKRPSMKQVVE +Ghl++ksDvy+fGvvlle+ltG ra+d+krp ++q+lvdw++plls++rkl++++D +++gqys+k + v++l+l Cl++ep++Rp+m++vve tGhltaksDvysfGvvllelltGrraldkkrpkeeqklvdwarpllsdkrkleriiDprlegqysakaaqkvaklalkClskepkeRpkmsevve 119.4 1.3e-36 RLK-Pelle_RLCK-VIIa-2 145 Cluster-1241.0-1F PF07714.14 13 107 182 260 HLYVKSDVYGFGVVLLEMLT-GLRAvdrkrplgkqnlvdwvKPLLSQRRKLKSVmDAQMDGQYSSKVLSLVSQLTLICLETEPRKRPSMKQVVEEL ++ +ksDv+ fGv+l E++t g + p ls+++ l+ + +++ + +k+ + + +l C+e++p++Rp++k++ve+l kftsksDvWsfGvllwEiftlgeep................ypglsneevlekl.kegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 28.0 7.9e-09 Protein tyrosine kinase 145 Cluster-1426.0-0F Group-Pl-3 190 239 148 197 KILRPDEFAETVCGSPQYMAPEVLQFQRYDEKVDMWSVGAILFELLNGCP + l+p+e+aet+cGsp ymaPevlq+q+yd+k+d+Wsvgailf+l++G p rslqpeelaetlcGsplymaPevlqlqkydakadlWsvgailfqlvtGrp 78.5 3.4e-24 Group-Pl-3 240 Cluster-1426.0-0F PF00069.22 194 239 150 195 PDEFAETVCGSPQYMAPEVLQFQRYDEKVDMWSVGAILFELLNGCP ++ +++++g+++Y+APEvl+ ++y++kvD+Ws+G il+ell+g+p ssskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkp 48.0 7e-15 Protein kinase domain 240 Cluster-1426.0-0F PF07714.14 205 237 170 202 PQYMAPEVLQFQRYDEKVDMWSVGAILFELLNG ++mapE+l+ +++ +k D+Ws G +l+E+++ vkWmapEslkekkftsksDvWsfGvllwEiftl 23.7 1.6e-07 Protein tyrosine kinase 240 Cluster-1426.0-2F Group-Pl-3 66 190 3 127 RSKLGESSLATVWEAENRTTRQVVALKQIHVTKLTRRLKNCLECELTFLSSVNHPNIIRLLDVIEVEGCIILVLEFCAGGNLASYIRRHGRVQECIARRFIQQLGAGLEVLKSHNVIHRDLKPED ++g s+a+vw+a++++t + va+k+i++++l ++l+++le+e+++l++++hpniirlld+ie e+ i lvle+c+GG+la+yi+r+g+v+e +a++f++ql+aGl+vl+++n+ihrdlkP++ teqigsgsfavvwkakhkstgeevavkeialerlnkklresleseiailrridhpniirlldlieeedkiylvleyceGGdlaayiqrkgkveeavakkflrqlaaGlkvlrenniihrdlkPqn 161.9 1.1e-49 Group-Pl-3 239 Cluster-1426.0-2F PF00069.22 64 189 2 127 VLRSKLGESSLATVWEAENRTTRQVVALKQIHVTKLTRRLKNCLECELTFLSSVNHPNIIRLLDVIEVEGCIILVLEFCAGGNLASYIRRHGRVQECIARRFIQQLGAGLEVLKSHNVIHRDLKPE +klGe s ++V +a +++t++ vA+K+i + k + + ++ + E+++l +++hpni+rl++v+e + ++lvle++ gg+la++++r+g ++e+ a+++++q+ +gle l s+++iHrDlKpe ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpe 96.5 1.1e-29 Protein kinase domain 239 Cluster-1426.0-2F PF07714.14 65 187 3 131 LRSKLGESSLATVWEAENR----TTRQVVALKQIHVTKLTRRLKNCLEcELTFLSSVNHPNIIRLLDVIEVEGCIILVLEFCAGGNLASYIRRH---GRVQECIARRFIQQLGAGLEVLKSHNVIHRDLK l +klGe + ++V+e++ + ++++ va+K+++ ++ ++ ++ le e++++++++hpni++ll v+ e+ +++v+e+++gG+L +++r++ +++ +f++q+ +G+e L+s++++Hrdl lgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefle.eakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdla 69.9 1.4e-21 Protein tyrosine kinase 239 Cluster-143.1-1R AGC_PKA-PKG 1 147 104 250 LENFHKNGVLYRGVTPDIIMLDQAGYIQLVDFRFGKKLScnfGERTYTICGMADTLAPEIIQGKGHGFPADWWAVGVLIYFMLHGEMPFGSWRESEL-TYARIVKGQLTLPQTFSLEAVDLITKLLDVDESTRLGSQ--GVDSIKSHPWF le++Hk++++yR++ p+ +++d++Gy++lvDf+f kkl+ gertyt+CG++d lAPE+++gkGhg +DwWa+Gvliy++l+ge+PF+s++++el +++rivk++l++P+++s ea+dli+kLL+v++++RlG++ g+ +ik+HpwF leelHkkeivyRdlkpenllidekGyvklvDfgfakkle...gertytlCGtpdylAPEvvkgkGhgkavDwWalGvliyvlltgekPFaslkddelevfrrivkeklkfPsylskeardliekLLevnpakRlGakkegaeeikeHpwF 207.8 1.6e-63 AGC_PKA-PKG 309 Cluster-143.1-1R PF00069.22 2 147 112 264 ENFHKNGVLYRGVTPDIIMLDQAGYIQLVDFRFGKKLSCNFGerTYTICGMADTLAPEIIQGKGHGFPADWWAVGVLIYFMLHGEMPFGSWRESELTYA---------RI---VKGQLTLPQTFSLEAVDLITKLLDVDESTRLGsqgVDSIKSHPWF e H++g+++r + p+ i++d+ g ++++DF + k+l+ + + +++g + lAPE++++++++ ++D+W++Gv++y +l g++pf + +++e +++ +i +k +l ++++s ea dl++kll++d+++Rl+ ++++++hp++ eylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRlt...aeellqhpyl 82.8 1.6e-25 Protein kinase domain 309 Cluster-143.1-1R PF07714.14 5 132 121 250 HKNGVLYRGVTPDIIMLDQAGYIQLVDFRFGKKL--SCNFGERTYTIcGMADTLAPEIIQGKGHGFPADWWAVGVLIYFMLH-GEMPFGSWRESELTYARIVKGQLTLPQTFSLEAVDLITKLLDVDESTR +++ ++ r ++ ++l++ +++ Df +++ + + +++ + +apE+++ k +D W+ Gvl++ ++ ge+p+ +++++e++ + + +l+ p++ + e +l+++ ++ d + R eskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeak.lpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeR 22.9 2.9e-07 Protein tyrosine kinase 309 Cluster-147.0-0R RLK-Pelle_DLSV 5 112 88 195 SQTVLDWRKRFNIIEGIGRGLLYLHRDSRLKIIHRDLKPSNILLDEEWNPKISDFGMA*I-FGGDQDQAKTKRVVGTYGYMSPEYALSGRFSEKSDVFSFGVLVLEIIS +++ ldW++rf+ii+gi rGllYLh++srlkiihrDlK+sNiLLd+e+npki+DFG+a f+ dq++a+tkrvvgt+gYm+Peyal+g++seksDv+sfGvlvlei+s kkkeldWktrfkiikgiarGllYLheesrlkiihrDlKasNiLLdkemnpkiaDFGla.rlfeedqteastkrvvgtlgYmaPeyalegqlseksDvysfGvlvleivs 177.6 2.2e-54 RLK-Pelle_DLSV 112 Cluster-147.0-0R PF00069.22 12 111 98 191 RKRFNIIEGIGRGLLYLHRDSrlkIIHRDLKPSNILLDEEWNPKISDFGMA*ifGGDQDQAKTKRVVGTYGYMSPEYALSGRFSEKSDVFSFGVLVLEII ++ +i++ i +gl ylH+ + iiHrDlKp+NiL+de+ + Ki+DFG+a + + k++ +vgt Y++PE + ++s+k+Dv+s Gv+++e++ eeakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGla...kelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyell 84.0 7.3e-26 Protein kinase domain 112 Cluster-147.0-0R PF07714.14 7 112 99 201 TVLDWRKRFNIIEGIGRGLLYLHRDSrlkIIHRDLKPSNILLDEEWNPKISDFGMA*IFG-GDQDQAKTKRVVGTYGYMSPEYALSGRFSEKSDVFSFGVLVLEIIS + l+ ++ ++++ i +G+ yL++ + ++Hrdl N+Ll+e+ kisDfG+a d+++ k+++ + +m+pE +++f++ksDv+sfGvl+ Ei++ ekltlkdllsfalqiAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLa.rdiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEift 69.9 1.3e-21 Protein tyrosine kinase 112 Cluster-1476.0-2F STE_STE11 1 93 163 255 YWMAPEVVMnTNGYSFAVDIWSLGCTVLEMATAKPPWSQ-YEGVAAIFKIGNSKDMPEIPDQLSNVAKSFIRLCLQRDPSARPTASELLGHPFL ++mapev++ ++++++a+DiwslGCtVlem+t+k+pws+ +e vaa+fkig+sk++Peip++ls+ ak F++ Clqrdp+ Rpta+eLL hpFl lymapevir.keelglaaDiwslGCtVlemltgkapwseleeevaalfkigkskelPeipeslseeakdFlskClqrdpaeRptaaeLLehpFl 135.1 2.5e-41 STE_STE11 124 Cluster-1476.0-2F PF00069.22 1 93 162 264 YWMAPEVVmNTNGYSFAVDIWSLGCTVLEMATAKPPWS----------QYEGVAAIFKIG-NSKDMPEIPDQLSNVAKSFIRLCLQRDPSARPTASELLGHPFL +++APEv+ ++n+ys +vD+WslG++++e+ t kpp+s +++ + +i+ki ++k + +++ls+ ak++++ +l++dp+ R+ta+ell hp+l eYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 77.1 8.8e-24 Protein kinase domain 124 Cluster-1476.0-2F PF07714.14 2 88 172 257 WMAPEVVMNTNgYSFAVDIWSLGCTVLEMAT-AKPPWSQYEGVAAIFKIgNSKDMPEIPDQLSNVAKSFIRLCLQRDPSARPTASELL WmapE++++++ ++ + D+Ws G ++ E++t ++ p+++++ ++ k+ +++ e p++ ++ +++++ C+++dp+ Rpt +el+ WmapEslkekk.ftsksDvWsfGvllwEiftlgeepypglsneevlekl.kegkrlekpekcpeelyelmkqCweedpeeRptfkelv 48.2 5.5e-15 Protein tyrosine kinase 124 Cluster-1503.0-0F TKL_CTR1-DRK-2 42 295 2 253 VLKGTIGSGSFGTVHLADWNGCEVAVKVLMEQDFLGERFKEFLREVAIMKRLRHPNIVLLMGAVTEPPNLSIVTEYLSKGSLYVLLRDPTARaaLNERRRLSMAYDVANGMNYLHKSNPPIVHRDLKSPNLLVDRKYSVKVCDFGLSRLKAKTFLSSKTAAGTPEWMAPEVLRDEPSNEKSDVYSFGVILWELATLQQPWSNLNAAQVIAAVGFKGKRLEIPSSVNPQVTAIIEACWADEPWKRPSFASIMESL +++ iG Gsfg+v+ a+w+G++vavkv+++qd+ e+++ef +ev++mkrlrhpn+vl+mGavt+p++lsivte+l++gsl++ll+ ++++ l+errrl++a+dva+G+nylhk++ppivhrdlks+nllvd++++vkv+dfGlsrlka+tflssk++aGtpewmapevlr+e+++eksdvysfGvilwel+t+++pw++lna+qv++avgf+ +rleip++v+p+v+++ie+cw+++p+krpsf++i+e+l tigeriGqGsfgevyraewkGsdvavkvflkqdlseealeefrkevslmkrlrhpnvvlfmGavtkpqrlsivteflprgslfrllerkksk..lderrrlklaldvarGlnylhklsppivhrdlkssnllvdknwtvkvadfGlsrlkaetflsskstaGtpewmapevlrneaadeksdvysfGvilwelvtekipweelnamqvvgavgfqnrrleipkevdpkvasliescwekdpkkrpsfseilekl 424.7 1.1e-129 TKL_CTR1-DRK-2 431 Cluster-1503.0-0F PF07714.14 42 295 2 260 VLKGTIGSGSFGTVHLADWN------GCEVAVKVLmEQDFLGERFKEFLREVAIMKRLRHPNIVLLMGAVTEPPNLSIVTEYLSKGSLYVLLRDPTARAALNERRRLSMAYDVANGMNYLHKSNppIVHRDLKSPNLLVDRKYSVKVCDFGLSRLK--AKTFLSSKTAAGTPEWMAPEVLRDEPSNEKSDVYSFGVILWELAT-LQQPWSNLNAAQVIAAVgFKGKRLEIPSSVNPQVTAIIEACWADEPWKRPSFASIMESL l+ ++G+G+fG+V+ + ++ ++vavK+l +++ e+ +efl+e++imk+l+hpniv l+g++t+ +l ivtey+++G+L Lr+ +++++l+ ++ ls+a+++A+Gm+yL++ + +vHrdl + N L++++ vk++DfGL+r ++ ++++a +WmapE+l+++ ++ksDv+sfGv+lwE++t ++p+++l++++v++++ +gkrle p++++++++ +++ Cw+ +p +Rp+f++++e l elgkklGeGafGeVvegtlkgekekkevkvavKtl.keeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskk..lvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevlekl.kegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 237.8 7.9e-73 Protein tyrosine kinase 431 Cluster-1503.0-0F PF00069.22 44 293 4 260 KGTIGSGSFGTVHLAD--WNGCEVAVKVLMEQDFLGERFKEFLREVAIMKRLRHPNIVLLMGAVTEPPNLSIVTEYLSKGSLYVLLRdptARAALNERRRLSMAYDVANGMNYLHKSNppIVHRDLKSPNLLVDRKYSVKVCDFGLSRLKAKTFLsSKTAAGTPEWMAPEVLRDEPSNEKSDVYSFGVILWELATLQQPWSNLN--------AAQ---VIAAVGFKGKRLEIPSSVNPQVTAIIEACWADEPWKRPSFASIME + ++G+GsfG+V a ++g++vAvK++ +++ ++ k++lrE++i+k+l+hpniv l+++++e+ +l +v+ey+++g+l ll+ ++ +l+e++ ++a+ +++g++ylH+ + i+HrDlK+ N+L+d+k +K++DFGl++ ++ ++ gt+e++APEvl++++ +k+Dv+s Gvil+el t ++p+s+ + + q ++ +g + + l+ +s+++++++ +++ +++ +p kR++++++++ leklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls...rkgslseeeakkiakqilegleylHskg..iiHrDlKpeNiLidekgelKitDFGlakelesssk.ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellq 194.1 1.9e-59 Protein kinase domain 431 Cluster-1623.0-0R CAMK_CDPK 97 311 1 213 YTIGKLLGHGQFGYTYVAIDKSNGDRVAVKKIEKNKMVLPIAVEDVKREVKILKALAGHENVVQFHNSFEDDSYVYIVMELCEGGELLDRILSKkdSRYTEKDAAIIVRQMLKVAAECHLHGLVHRDMKPENFLFKSPKEDSSLKATDFGLSDFIRPGKKFQDIVGSAYYVAPEVLKRKSGPESDVWSIGVITYILLCGRRPFWDKTEDGIFKEV y++gk lG+G+fG++++a +k++g++vAvK i+k+k++ +vedv+revkilk+l+gh+nvvq+++ +ed++ v++vmelceggelldril++ ++y+e++aa +vrq+l+v a+cH +g+vhrD+KPeNfl++s +ed++lka+DFGls+f+++g++++divGs+yyvaPEvlkr+ g+e+dvWs+Gvi+yillcg++pfw++te++ifk+v yelgkelGrGefGvvrlatekatgeevAvKsiskrklskaedvedvrrevkilkhlsghknvvqlkgayedkdsvhlvmelceggelldrilar..gkyseraaakvvrqilevvaacHskgvvhrDlKPeNflltskeedaplkaiDFGlsvfvkegerledivGspyyvaPEvlkrsygkeadvWsaGvilyillcgvppfwaeteeeifkav 310.4 8.1e-95 CAMK_CDPK 380 Cluster-1623.0-0R PF00069.22 97 307 1 205 YTIGKLLGHGQFGYTYVAIDKSNGDRVAVKKIEKNKMVLPIAvEDVKREVKILKALAgHENVVQFHNSFEDDSYVYIVMELCEGGElLDRILSKKDSrYTEKDAAIIVRQMLKVAAECHLHGLVHRDMKPENFLFKSPKEdssLKATDFGLSDFIRPGKKFQDIVGSAYYVAPEVL-KRKSGPESDVWSIGVITYILLCGRRPFWDKTEDGI y+ + lG G+fG y a++k++g+ vAvKki+k+k+ ++v rE+kilk l h+n+v++ ++fe+++++y+v+e++egge l+++ls+k s ++e++a i++q+l+ + +H +g++HrD+KpeN+L+++ +e lK tDFGl+ ++ ++k++++vg+ +Y+APEvl +++ ++++DvWs+Gvi y ll+g+ pf++++++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklk.hpnivrlyevfeekdelylvleyvegge.ladllsrkgs.lseeeakkiakqilegleylHskgiiHrDlKpeNiLidekge...lKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkek 193.0 4e-59 Protein kinase domain 380 Cluster-1623.0-0R PF07714.14 99 308 3 216 IGKLLGHGQFGYTYVAIDK----SNGDRVAVKKIEKNKMVlpIAVEDVKREVKILKALaGHENVVQFHNSFEDDSYVYIVMELCEGGELLDRILSK-KDSRYTEKDAAIIVRQMLKVAAECHLHGLVHRDMKPENFLFKSpkeDSSLKATDFGLSDFI---RPGKKFQDIVGSAYYVAPEVLKRK-SGPESDVWSIGVITYILLC-GRRPFWDKTEDGIF +gk lG+G+fG + ++ k ++ +vavK+++++++ + e++ +e+ki+k+l h+n+v+++ +++ ++iv+e++egG+Ll+ + +k ++++ t kd +++q+ k + + + lvHrd+ N L ++ ++ k +DfGL++ i kk ++ + ++apE+lk+k +sDvWs Gv+++ +++ g++p+++ ++ ++ lgkklGeGafGeVvegtlkgekekkevkvavKtlkeeate..eekeefleeakimkkl.khpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlse...nkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevl 100.2 7.6e-31 Protein tyrosine kinase 380 Cluster-1642.0-1R TKL-Pl-2 1 195 77 280 GKKRVAAELSLFIARDVAFALSELHSKHIIHRDIKSENILIDLDKKRPDGTPTVKICDFDRAIPLRSCLHTCCIAHVGIPRPDTCVGTPRWMAPEVFRAMDRPNIYGLEVDIWSFGCLLLELLTLQVPYSGVAESEIHNLLQMGERPPLTEELELLAQSDEE-----L----ETDSETLKFLVKLYIQCTEKNPSDRPTAENLY Gkk v+ +l+l iar+va al elhsk+iihrdiksen+lidld++++dG+p vk+cdfd+a+plrs +htcciah+G+p ++ cvGtprw+apev+ram n yGlevdiwsfGcl+lelltl+vpysg++eseih+ lq+g+rp l++ele l+ d++ + e++ ++l++l++l+ qct++ ps+rp+a++++ GkkfvsidlalsiarevacallelhskdiihrdiksenvlidldsqsadGepvvklcdfdsavplrssthtcciahlGvppinvcvGtprwlapevlramreknayGlevdiwsfGclvlelltlrvpysglleseiheilqkgkrprlskelealisedkpekktevfilsedeadklrllidlfyqctkespserpkakevf 298.8 3.5e-91 TKL-Pl-2 289 Cluster-1642.0-1R PF00069.22 11 196 101 260 LFIARDVAFALSELHSKHIIHRDIKSENILIDlDK-KrpdgtptVKICDFDRAIPLRSCLHtcciahvgiprPDTCVGTPRWMAPEVFramdRPNIYGLEVDIWSFGCLLLELLTLQVPYSGVAESE--IHNLLQmgerppLTEELELLAQSDEELETDSETLKFLVKLYIQCTEKNPSDRPTAENLYN +ia+ ++ +l+ lHsk+iiHrD+K+eNiLid +k + +Ki+DF+ a l+s+ + ++ vgt++++APEv + n y+ +vD+Ws G++l+ellt + p+sg ++e ++l q l++ l++l +++e+l+++se + + +l ++ +k+p++R+tae+l + kkiakqilegleylHskgiiHrDlKpeNiLid.ekge.......lKitDFGlakelesssk...........ltsfvgtreYlAPEvl....keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldq......lekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellq 116.5 8.3e-36 Protein kinase domain 289 Cluster-1642.0-1R PF07714.14 5 198 101 260 VAAELSLFIARDVAFALSELHSKHIIHRDIKSENILIDLdkkrpdgTPTVKICDFDRAIPLRSCLHTcciahvgiPRPDTCVGTPRWMAPEVFRAMDrpniYGLEVDIWSFGCLLLELLT-LQVPYSGVAESEihnllqmgerpplteELELLaQSDEELETDSETLKFLVKLYIQCTEKNPSDRPTAENLYNTL + + l +a+++A +++ L+sk+++Hrd+ + N+L++ + +vki+Df a +++ ++ + +++ +WmapE+++++ + + D+WsfG ll E++t + py+g+ ++e le l +++++le+ +++ + l +l qC e++p++Rpt ++l ++l ltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlse.......nkvvkisDfGLardiekddey........kkkeeaklpvkWmapEslkekk....ftsksDvWsfGvllwEiftlgeepypglsnee...............vlekl.kegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 75.7 2.3e-23 Protein tyrosine kinase 289 Cluster-165.0-2R RLK-Pelle_LRR-XIV 13 218 1 206 LIKHGHSGDIFLGMLEDGRKVVIKKVDLILLGEELYMSELDLLGKTTHPRFVQLVGHCLENENEKFLVYKYMPNGDLSNSFYRLSNSG-DESLQSLDWITRLKIAIQTAEALAYLHHEFTPPLVHRDIQASSIFLDEKYDVRLGSLSEVCAQGGDNHKNVIARFLHMPQTSRRHSSGsSSSAICAYDIYCFGKLLLEIITGRVGITA lik+GhsGd++ G+le+G +vv+kk+dl +e y+sel+ll k++h r+v+l+Ghcl++e+ekflvyky++ngdl++++++ s++ ++ l+sldwitrlkiai aeal+ylh+e +Pplvhrd++assi+ld+k++vrlGsls+++aq ++++++vi+r+l ++q+s +++sg +++a+c+yd+ycfGk+lle++tG++Gi++ likkGhsGdlykGvlesGtavvvkkidlkkvkkeaylselellekasherlvpllGhcldkeeekflvykyvangdlasalhkksseekedglksldwitrlkiaiGvaealsylhsecsPplvhrdvkassillddkfevrlGslsdaraqdsegkqsvisrllrlsqssdkadsg.aaaascsydvycfGkvllelvtGklGisg 299.1 2.4e-91 RLK-Pelle_LRR-XIV 219 Cluster-165.0-2R PF07714.14 13 211 6 201 LIKHGHSGDIFLGMLE-----DGRKVVIKKVDLILLGE--ELYMSELDLLGKTTHPRFVQLVGHCLeNENEKFLVYKYMPNGDLSNSFYRLsnsgdESLQSLDWITRLKIAIQTAEALAYLHHEFtppLVHRDIQASSIFLDEKYDVRLGS--LSEVC--AQGGDNHKNVIARFLHMPQTSRRHSSgssssAICAYDIYCFGKLLLEIIT + +G+ G+++ g l+ + kv++K+++ e e ++e++++ k+ hp+ v+l+g c+ +e++ ++v +y+++GdL++ + e+ ++l+ + l++a+q A++++yL+++ lvHrd+ a ++l+e+ v+++ L++ + ++++ ++ m+ s ++++ + D+++fG ll Ei+t klGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvct.keepllivteyvegGdLlkfLrkk.....eekekltlkdllsfalqiAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekk.....ftsksDvWsfGvllwEift 68.4 3.8e-21 Protein tyrosine kinase 219 Cluster-165.0-2R PF00069.22 11 213 4 194 ENLIKHGHSGDIFLGM-LEDGRKVVIKKVDLILLGEE---LYMSELDLLGKTTHPRFVQLVGHCLEnENEKFLVYKYMPNGDLSNSFYrlsnsgdE------SlqsldwiTRLKIAIQTAEALAYLHHEFtppLVHRDIQASSIFLDEKYDVRLGS--LSEVCAQGGDNHKNVIARFLHMPQTSrrhssgSSSSAICAYDIYCFGKLLLEIITGR ++ + G +G ++ ++ e+g++v++Kk++ ++ +++E+ +l k+ hp+ v+l++ + e ++e +lv y+++g+l + + + + kia q++e+l+ylH++ ++HrD+ + i++dek +++++ l++ ++ + ++ v+ r P ++++ + D++ G +l+e++tg+ leklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee.kdelylvleyveggeladlls.......rkgslsee.......eakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtreYlAPEvl......keneyskkvDvWslGvilyelltgk 56.3 2e-17 Protein kinase domain 219 Cluster-1665.0-2F PEK_GCN2 4 152 138 301 KWEIFKQILEGLAHIHERGFVHRDLTPKNIFLDESGNIKIGDFGLAMKIDDKGNCEDSIPIAST----MHQALLVVPEY--GKEVDTRSDSNDtKKIDIFNLGPILGGVLYAYS--VEKVL---RCSANGDFPENWL-----EAPLILRLMATKNSDRPSIPDLM w++++qi+eGlahih +G +hrdltp+nif d ++ikiGdfGla + + +d+ a++ ++++ v + e+ d +k+d++ lG +l + y ++ +e+ + +G+ p++w +a l+ rl+a++ sdrps +l+ awrllrqiveGlahihsqGiihrdltpnniffdarndikiGdfGlakflkleqldkdtnlsaevagvslegtGqvGtyfytapeieqkwpkid.ekvdlyslGvvlfelwypfatameravilsdlkskGelplawatefpeqakllrrllapspsdrpsavell 85.2 4.3e-26 PEK_GCN2 231 Cluster-1665.0-2F PF00069.22 6 108 102 192 EIFKQILEGLAHIHERGFVHRDLTPKNIFLDESGNIKIGDFGLAMKIDDKGNcedsipIASTMHQALLVVPEYGkevdtrSDSNDTKKIDIFNLGPILGGVLY +i+kqilegl+++H++g++HrDl p+Ni++de+g++Ki+DFGla +++ + + s + + PE ++++ +kk+D++ lG il +l+ kiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk......ltsfvgtreYlAPEvl......keneyskkvDvWslGvilyellt 69.2 2.2e-21 Protein kinase domain 231 Cluster-1665.0-2F PF07714.14 5 57 107 159 WEIFKQILEGLAHIHERGFVHRDLTPKNIFLDESGNIKIGDFGLAMKIDDKGN ++ +qi +G+++++++ +vHrdl+ +N++l+e+ +ki+DfGLa +i ++ + lsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekdde 47.4 9.6e-15 Protein tyrosine kinase 231 Cluster-1834.0-2R RLK-Pelle_LRR-Xa 2 50 145 193 NESSFVNGDLGELGYVAPEYSTTMVASLKGDVYSFGVVLLELATANRAK ++s+fvnGd+g+lGyvaPeys+t+va+lkGdvysfGvvllel t++++ hlstfvnGdfgdlGyvaPeysrtlvatlkGdvysfGvvllelvtgqkpv 79.2 2e-24 RLK-Pelle_LRR-Xa 150 Cluster-1834.0-2R PF07714.14 14 46 170 202 LGYVAPEYSTTMVASLKGDVYSFGVVLLELATA + ++apE ++++ + k Dv+sfGv+l E++t vkWmapEslkekkftsksDvWsfGvllwEiftl 22.2 4.7e-07 Protein tyrosine kinase 150 Cluster-189.0-1R CK1_CK1 42 139 1 98 FRLGRKLGSGSFGEIYLGTNIHTNEEVAIKLENVKTKHPQLLYESKLYKLLQGGTGIPKISWFGVEGDYNALVMDLLGPSLEDLFNFCSQKLSLKTVL f+lgrk+gsgsfgeiylgtn++tneevaikle+vktkhpqllyeskly++lqggtgip++ wfgvegdyn+lv+dllgpsledlfn+cs+k+slktvl fklgrkigsgsfgeiylgtnvqtneevaiklesvktkhpqllyesklyrilqggtgipnlkwfgvegdynvlvldllgpsledlfnycsrkfslktvl 171.3 1.7e-52 CK1_CK1 139 Cluster-189.0-1R PF00069.22 43 132 2 92 RLGRKLGSGSFGEIYLGTNIHTNEEVAIKLENVKTKHP----QLLYESKLYKLLQgGTGIPKISWFGVEGDYNALVMDLLGPSLedLFNFCSQK + +klG+GsfG++y +++ +t+++vA+K +++ + ++l E k+ k l+ i ++ + e d+ lv++++ l+++ s+k ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklk.hpnivrlyevfeekdelylvleyvegge..ladllsrk 28.3 6.7e-09 Protein kinase domain 139 Cluster-190.0-1R RLK-Pelle_RLCK-VIIa-2 67 170 2 105 LLGEGGFGYVFKGWIDETALMATKRGSGIVIAVKKLKPEGFQGHKEWLTEVNYLGQLHHPNLVKLIGYCSEGDNRLLVYEFMSKGSLENHLFRRGPQPLSWAIR llGeGgfG v+kg+ide++ ++k+g+g+++avkkl++eg+qghkewl+ev++Lgql+hpnlvkliGyc e d+rllvyE+m+kgslenhlfrr ++lsW++r llGeGgfGsvykgvidektkaelkageglavavkklnkeglqghkewlaevefLgqlshpnlvkliGycledderllvyEymakgslenhlfrrssealsWetr 164.1 3e-50 RLK-Pelle_RLCK-VIIa-2 170 Cluster-190.0-1R PF07714.14 66 160 5 95 SLLGEGGFGYVFKGWIDEtalmaTKRGSGIVIAVKKLKPEGFQG-HKEWLTEVNYLGQLHHPNLVKLIGYCSEGDNRLLVYEFMSKGSLENHLFRR + lGeG fG V++g +++ +k+ + + +avK+lk e + ++e l+e++ + +l+hpn+vkl+g c+++++ l+v e++++G+L+++L ++ kklGeGafGeVvegtlkg.....ekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk 62.0 3.3e-19 Protein tyrosine kinase 170 Cluster-190.0-1R PF00069.22 65 159 4 91 DSLLGEGGFGYVFKgwidetalmATKRGSGIVIAVKKLKPEGFQGHK--EWLTEVNYLGQLHHPNLVKLIGYCSEGDNRLLVYEFMSKGSLENHLFR ++ lGeG+fG V+k a+++ +g +AvKk+k e + k + l+E+++l +l+hpn+v+l+++++e d+++lv e++++g+l+++l r leklGeGsfGkVyk.........aveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsr 48.2 5.9e-15 Protein kinase domain 170 Cluster-1906.1-0R AGC_NDR 1 40 123 153 RDIKPDNLLLDRYGHLKLSDFGLCKPLDCSilqedfsvgE rdikpdnllld++ghlklsdfglckpld++ rdikpdnllldkeghlklsdfglckpldak.........l 51.8 5.2e-16 AGC_NDR 215 Cluster-1906.1-0R PF00069.22 1 28 122 149 RDIKPDNLLLDRYGHLKLSDFGLCKPLD rD+Kp+N+L+d+ g+lK++DFGl+k l+ rDlKpeNiLidekgelKitDFGlakele 27.8 9.8e-09 Protein kinase domain 215 Cluster-1946.0-2F RLK-Pelle_DLSV 7 111 2 106 NKLGEGGFGPVYKGKLQDGQEIGVKRLSQRSKQGAKEFENEVALASILQHVNLVKLLGVCIEGEEKMLIYEYMPNKSLDTYLFDPVKRLSLDWEKRVQIIEGVSQ nklGeGgfg vYkgkl+dg+e+ vkrls++skqg++ef+nev+l + lqh nlvkLlg+ciegeek+l+yey++nksLd++lfd+ k+ +ldW++r++ii+g+++ nklGeGgfgkvYkgkledgkevAvkrlskkskqgkeefknevvliaklqhrnlvkLlgcciegeekllvyeylenksLdkflfdeekkkeldWktrfkiikgiar 156.8 4.9e-48 RLK-Pelle_DLSV 111 Cluster-1946.0-2F PF07714.14 6 110 4 114 VNKLGEGGFGPVYKGKLQ-----DGQEIGVKRLSQRSKQG-AKEFENEVALASILQHVNLVKLLGVCIEGEEKMLIYEYMPNKSLDTYLFDPVKRLSLDWEKRVQIIEGVS +klGeG fG V++g+l+ + +++ vK l++++++ +ef +e+++ + l+h n+vkllgvc+++e+ +++ ey+++ +L+++L + ++ +l+ ++ ++++ ++ gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiA 66.2 1.8e-20 Protein tyrosine kinase 111 Cluster-1946.0-2F PF00069.22 6 89 4 90 VNKLGEGGFGPVYKGK-LQDGQEIGVKRLSQRSKQGAKE--FENEVALASILQHVNLVKLLGVCIEGEEKMLIYEYMPNKSLDTYLF ++klGeG+fG Vyk++ ++g+++ vK++++++++ ke + +E+++ l+h n+v+l++v+ e +e +l+ ey+++++l+++l leklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls 51.8 4.8e-16 Protein kinase domain 111 Cluster-1951.0-0R RLK-Pelle_RLCK-IXb 118 368 2 252 KIGEGGYGPVYKATLDHTAVAIKVLRSEISQGQKQFHREVEVLSRLRHPNMVILLGVCPEYGCLVYEHMENGSLEDRLFCKNGTPTIPWPTRFRIAAEIATALLFLHQERPEPFVHRDLKPANILLDRNYVSKISDVGLCRLVPPSMEGGDTEYRMTAAAGTFCYIDPEYQQTGMLGTKSDIYSFGVMMLQIISAKPAMGLTYHVERALEKGQLEEILDESVKDWPVDEATSFAELALKCCELRKKDRPDL kiGeggyg+vYk++ldht+va+kvl+++ +qg+k+f++evevls++rHpn+v LlG+cpe+g+LvYe+++nGsLedrL++k+++++++W +r+riaaeia+aLlfLH+++pep vHrdlkpanilld+n+vsk+sdvGl+rl++ +++ + te+++t++agt++yidpeyq+tg+l +ksD+y++G+++Lq++ +k+++gl+ +ve+alek++l+e+ld+s++dwpv+ea+++a+lal+c+elr+kdRPdl kiGeggygkvYkgkldhtevavkvlkedslqgekefqqevevlskirHpnlvlLlGacpeagaLvYeylpnGsLedrLlrkknskplsWeervriaaeiasaLlfLHsakpepivHrdlkpanilldenlvsklsdvGlarllkeavaeaatelketslagtlayidpeyqrtgeltpksDvyalGiilLqlltgksplglakkveealekkklkevldksagdwpveeaeklaklalrcaelrrkdRPdl 390.9 2.1e-119 RLK-Pelle_RLCK-IXb 410 Cluster-1951.0-0R PF07714.14 116 371 4 256 SEKIGEGGYGPVYKATLD------HTAVAIKVLRSEISQG-QKQFHREVEVLSRLRHPNMVILLGVCP--EYGCLVYEHMENGSLEDRLFCKNGTPTIPWPTRFRIAAEIATALLFLHQERpepFVHRDLKPANILLDRNYVSKISDVGLCRLVppsmEGGDTEYRMTAAAGTFCYIDPEYQQTGMLGTKSDIYSFGVMMLQIIS--AKPamgltyhVERALEKGQLEEILDESVKDWPVDEATSFAELALKCCELRKKDRPDLGSV ++k+GeG +G V+++tl+ ++ va+K+l++e ++ +++f +e++++++l+hpn+v llgvc e ++v e++e+G+L++ L k+ ++++ + +++a++iA ++ +L++++ +vHrdl N+Ll++n v kisD GL+r + e d+ ++ + a + ++ pE +++ + +ksD++sfGv++ i++ ++p +++ ++ le + ++ + p + ++++el +C+e ++++Rp++ ++ gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLardi....ekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep.......ypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkel 141.6 1.8e-43 Protein tyrosine kinase 410 Cluster-1951.0-0R PF00069.22 114 368 2 255 SDSEKIGEGGYGPVYKAT--LDHTAVAIKVLRSEISQGQ--KQFHREVEVLSRLRHPNMVILLGVCP--EYGCLVYEHMENGSLEDRLFcKNGTptIPWPTRFRIAAEIATALLFLHQERpepFVHRDLKPANILLDRNYVSKISDVGLCRLVPPSMEggdteyrMTAAAGTFCYIDPEYQQTGMLGTKSDIYSFGVMMLQIISAKPAMG---LTYHVERALEK-GQLEEILDESVKDWPVDEA--TSFAELALKCCELRKKDRPDL ++ ek+GeG++G Vyka+ ++ vA+K+++ e + + k++ rE+++l +l+hpn v l++v+ ++ +lv e++e+g+l+d+l ++g+ ++ + +ia++i+++l +lH+++ ++HrDlKp+NiL+d++ + Ki+D Gl++ + s + +t gt Y+ PE ++ + ++k+D++s Gv+++++++ kp + + +ve+ l++ ++ +il+e+ +++p+++ ++ +l k+++ +k+R+ ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls.rkgs..lseeeakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk.......ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRlta 140.7 3.5e-43 Protein kinase domain 410 Cluster-1970.0-2R TKL-Pl-4 4 261 2 253 GPKIGEGAHAKVYEGKYKNQNVAIKIVHKG-ETPEEVAKREDRFAREVAMLSKVQHKNLVKFIGAC-KEPIMVIVTELLLGGTLRKYLLNLRPKCLDLRVAIGFALDIARAMECLHSHGIIHRDLKPENLLLTADhKTVKLADFGLAREESLTEMMTAETGTYRWMAPELYstvtlrhgEKKHYNHKVDAYSFAIVLWELIHNKLPFEGMSNLQAAYAAAFKNVRPS-ADDLPEDLALIVTSCWSEDPNSRPNFTQIIQML g ki+eGa++k+y+gkyk+q+va+Ki+++g e++ee a++e++f++eva+lsk++Hkn+vkfigac kep ++ivte+l gg+l+kyl + ++k l+l+v++ +aldiar++e+lhs++i+HrDlk+enlll+++ k+vK+aDfG+ar+e+ +e+mtaetGtyrwmaPE++ ekk+y++kvD ysf+ivlWel+++k+p+e++++lqaa+a++ kn+Rp+ ++++pe+la ++++cw++dp++Rp+f++i+++l gekiaeGalgklykgkykeqdvavKileageekeeeaaelekefkqevavlsklkHknvvkfigactkepalcivteylkggslkkylekkkkkklklkvvvklaldiargleylhskkivHrDlkaenllldee.kvvKiaDfGvarveaqseemtaetGtyrwmaPEvl........ekkpydrkvDvysfgivlWelltgkvpyedltplqaavavvqknlRpeipkevpealaellercwkadpekRpefseivkll 348.6 1.8e-106 TKL-Pl-4 415 Cluster-1970.0-2R PF07714.14 4 261 4 260 GPKIGEGAHAKVYEGKYK------NQNVAIKIVHKGETPEEvakrEDRFAREVAMLSKVQHKNLVKFIGACK-EPIMVIVTELLLGGTLRKYLLNL-RPKCLDLRVAIGFALDIARAMECLHSHGIIHRDLKPENLLLTADHkTVKLADFGLAREE---SLTEMMTAETGTYRWMAPELYSTVTlrhgekkhYNHKVDAYSFAIVLWELIH-NKLPFEGMSNLQAAYAAAFKNVRPSADDLPEDLALIVTSCWSEDPNSRPNFTQIIQML g k+GeGa ++V+eg++k +++va+K+++++ t ee +++f +e+++++k++h+n+vk++g+c e ++ivte++ gG+L+k+L + + + l+l+ + fal+iA++me L+s+ ++Hrdl N Ll+ ++ +vk++DfGLar+ + +++ + ++ ++WmapE ++ + +++k D +sf ++lwE++ + p++g+sn +++ + ++ + ++ pe+l+ ++++Cw+edp++Rp+f+++++ l gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateee....keefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenk.vvkisDfGLardiekddeykkkeeaklpvkWmapEslkekk........ftsksDvWsfGvllwEiftlgeepypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 192.2 6.3e-59 Protein tyrosine kinase 415 Cluster-1970.0-2R PF00069.22 5 259 5 260 PKIGEGAHAKVYEGK--YKNQNVAIKIVHKGETPEEVAkreDRFAREVAMLSKVQHKNLVKFIGACKE-PIMVIVTELLLGGTLRKYLLnlRPKCLDLRVAIGFALDIARAMECLHSHGIIHRDLKPENLLLTaDHKTVKLADFGLAREESLTEMMTAETGTYRWMAPELYstvtlrhgEKKHYNHKVDAYSFAIVLWELIHNKLPFE---GMSNLQAAYAA---------AFKNVRPSADDLPEDLALIVTSCWSEDPNSRPNFTQIIQ k+GeG+ +kVy+++ +++ vA+K++ k ++ ++ ++++rE+++l k++h+n+v+++++++e +++v+e++ gg+l ++l r ++l+ + a +a i++++e lHs+giiHrDlKpeN+L++ +++ +K++DFGla+e + ++ +t ++gt +++APE+ ++++y +kvD +s +++l+el+ +k pf+ g ++ ++ + k+ p a++l+e++ ++++++++dp++R+ +++++q eklGeGsfGkVykaveketgkivAvKkikkekakkkke...kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls..rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLid.ekgelKitDFGlakelessskltsfvgtreYlAPEvl........keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellq 179.3 6.2e-55 Protein kinase domain 415 Cluster-1972.0-0R TKL-Pl-4 141 392 2 253 GQAFAQGAFGKLYKGTYNNQDVAIKLLEKPENDPERAQLMEQQFQQEVMMLARLKHPNIVRFIGACRKPMVWCIVTEYAKGGSVRQFLAKRQNRSVPLKLAVKQALDVARGMEYVHGLNLIHRDLKSDNLLISADKSIKIADFGVARIEVQTEGMTPETGTYRWMAPEMIQHRPYTQKVDVYSFGIVLWELITGMLPFQNMTAVQAAFAVVNKGVRPSIPSDCLPVLSDIMTRCWDANPDVRPPFTEVVRLL g+ +a+Ga+gklykg+y++qdva+K+le++e+++e+a+ +e++f+qev++l++lkH+n+v+figac+k++++civtey kggs++++l k+++++++lk +vk ald+arg+ey+h +++HrDlk++nll++++k++KiaDfGvar+e q+e mt etGtyrwmaPE+++++py++kvDvysfgivlWel+tg +p++++t++qaa+avv+k++Rp+ip+++ + l+++++rcw+a+p+ Rp f+e+v+ll gekiaeGalgklykgkykeqdvavKileageekeeeaaelekefkqevavlsklkHknvvkfigactkepalcivteylkggslkkylekkkkkklklkvvvklaldiargleylhskkivHrDlkaenllldeekvvKiaDfGvarveaqseemtaetGtyrwmaPEvlekkpydrkvDvysfgivlWelltgkvpyedltplqaavavvqknlRpeipkevpealaellercwkadpekRpefseivkll 391.8 1.2e-119 TKL-Pl-4 452 Cluster-1972.0-0R PF07714.14 139 392 2 260 NMGQAFAQGAFGKLYKGTYN------NQDVAIKLLEKPENDPEraqlmEQQFQQEVMMLARLKHPNIVRFIGACRKPMVWCIVTEYAKGGSVRQFLAKR-QNRSVPLKLAVKQALDVARGMEYVHGLNLIHRDLKSDNLLISADKSIKIADFGVARIE---VQTEGMTPETGTYRWMAPEMIQHRPYTQKVDVYSFGIVLWELIT-GMLPFQNMTAVQaAFAVVNKGVRPSIPSDCLPVLSDIMTRCWDANPDVRPPFTEVVRLL ++g+ ++GafG+ ++gt++ +++va+K l++ ++ e +++f +e+ ++ +lkhpniv+++g+c k +ivtey++gG++++fL k+ +++++ lk ++ al++A+Gmey + +l+Hrdl + N L+s +k +ki+DfG+ar +++ + ++ ++WmapE+++++ +t+k Dv+sfG++lwE++t g p++++++ + +++ +++g r + p++c + l ++m++Cw+++p+ Rp f+e+v+ l elgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateee.....keefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsnee.vleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 233.0 2.3e-71 Protein tyrosine kinase 452 Cluster-1972.0-0R PF00069.22 146 389 9 259 QGAFGKLYKGT--YNNQDVAIKLLEKPENDPERAqlmeQQFQQEVMMLARLKHPNIVRFIGACRKPMVWCIVTEYAKGGSVRQFLAkrQNRSVPLKLAVKQALDVARGMEYVHGLNLIHRDLKSDNLLISADKSIKIADFGVARIEVQTEGMTPETGTYRWMAPEMIQHRPYTQKVDVYSFGIVLWELITGMLPFQ----------NMTAVQAAFAVVNK-GVRPSIPSDCLPVLSDIMTRCWDANPDVRPPFTEVV +G+fGk yk++ +++ vA+K ++k +++ ++ +++++E+ +l++lkhpnivr++++++++ ++v+ey++gg++ ++l ++ s++ + a k a +++g+ey+H ++iHrDlK++N+Li+ ++ +Ki+DFG+a+ +++ +t ++gt +++APE++++++y++kvDv+s G++l+el+tg pf+ +++ +++ + ++++ + +s++ + + d+++++++ +p R+ ++e++ eGsfGkVykaveketgkivAvKkikkekakkkke....kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls..rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeell 193.4 2.9e-59 Protein kinase domain 452 Cluster-1976.0-1R CK1_CK1 1 115 30 144 KLENVKTKHPQLLYESKLYRILQGGNGIPNVRWFGAEGDYNVLVMDLLGPSLEDLFNFCSRKLSLKTVLMLADQMINRVEFVHCKSFLHRDIKPDNFLMGLGRRANQVYIIDFGL kle+vktkhpqllyesklyrilqgg+gipn++wfg egdynvlv+dllgpsledlfn+csrk+slktvlmladq+inrve+vh k+flhrdikpdnflmglgr+anqvyiidfgl klesvktkhpqllyesklyrilqggtgipnlkwfgvegdynvlvldllgpsledlfnycsrkfslktvlmladqlinrveyvhskgflhrdikpdnflmglgrkanqvyiidfgl 233.2 2.2e-71 CK1_CK1 115 Cluster-1976.0-1R PF00069.22 5 115 38 144 VKTKHPQLLYESKLYRILQgGNGIPNVRWFGAEGDYNVLVMDLLGP-SLEDLFNfCSRKLSLKTVLMLADQMINRVEFVHCKSFLHRDIKPDNFLMGlgrRANQVYIIDFGL k+k+ ++l E k+ + l+ + i ++ + e d+ +lv++++ +l+dl + + +ls +++ +a q+++ +e++H+k+++HrD+Kp+N+L+ + +++ i+DFGl kkkkekkvlrEikilkklk.hpnivrlyevfeekdelylvleyveggeladlls.rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLid...ekgelKitDFGl 45.9 3e-14 Protein kinase domain 115 Cluster-1976.0-1R PF07714.14 38 115 73 150 GDYNVLVMDLLG-PSLEDLFNFC--SRKLSLKTVLMLADQMINRVEFVHCKSFLHRDIKPDNFLMGLgrrANQVYIIDFGL ++ ++v++++ +L++ + ++kl+lk++l +a q+ + +e+ + k+++Hrd+ N L+ ++v i DfGL eepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlse...nkvvkisDfGL 24.1 1.3e-07 Protein tyrosine kinase 115 Cluster-1987.0-1R CMGC_GSK 85 133 1 49 AERVVGTGSFGIVFQAKCLETGEAVAIKKVLQDKRYKNRELQLMRMMNH aervvgtgsfg+vfqakcletge+vaikkvlqdkryknrelq+mr+++h aervvgtgsfgvvfqakcletgetvaikkvlqdkryknrelqimrlldh 88.0 4.8e-27 CMGC_GSK 133 Cluster-1987.0-1R PF00069.22 83 133 1 57 YMAERVVGTGSFGIVFQAKCLETGEAVAIKKVLQDKRYKN------RELQLMRMMNH y ++ +G+GsfG V++a+ etg+ vA+Kk+ ++k+ k+ rE+++++ ++h yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkh 27.0 1.7e-08 Protein kinase domain 133 Cluster-2021.0-1F RLK-Pelle_RLCK-VIIa-2 106 379 2 275 LLGEGGFGYVFKGWIDANTLTATRPGSGLVIAVKKLKPEGFQGHKEWLTEVNYLGQLHHRNLVKLIGYCSEGDYRLLVYEFMPKGSLENHLFRRGPQPLNWATRIKVAIDAARGLSFLHEAEHHIIYRDFKASNILLDGEFNAKLSDFGLAKAGPTGDKTHVSTQVMGTQGYAAPEYVATGRLTSKSDVYSFGVVLLELLSGRRAVDKDKFGVEQNLVDWAKPYMGDKRKVFRIMDTKLEGQYPQKAAHTAATIALQCLSREPKLRPNMTEVLS llGeGgfG v+kg+id++t +++++g+gl++avkkl++eg+qghkewl+ev++Lgql+h+nlvkliGyc e d rllvyE+m+kgslenhlfrr ++l W+tr+k+a++aA+gl+fLheae+++iyRdfkasniLld +fnaklsdfglak+gp++dkthvst+vmgt+gYaaPeyvatG+lt+ksDvysfGvvllell+Grra+dk + eq+lvdwa+p++ dkrk+ ri+D++legqy++kaa+++a++al+Cls+epk Rp+m+ev++ llGeGgfGsvykgvidektkaelkageglavavkklnkeglqghkewlaevefLgqlshpnlvkliGycledderllvyEymakgslenhlfrrssealsWetrlkialgaAkglafLheaekkviyRdfkasniLldedfnaklsdfglakegpeedkthvstrvmgtygYaaPeyvatGhltaksDvysfGvvllelltGrraldkkrpkeeqklvdwarpllsdkrkleriiDprlegqysakaaqkvaklalkClskepkeRpkmsevve 455.7 3.7e-139 RLK-Pelle_RLCK-VIIa-2 522 Cluster-2021.0-1F PF07714.14 105 381 5 260 SLLGEGGFGYVFKGWIDAntltaTRPGSGLVIAVKKLKPEGFQG-HKEWLTEVNYLGQLHHRNLVKLIGYCSEGDYRLLVYEFMPKGSLENHLFRR-GPQPLNWATRIKVAIDAARGLSFLHEaeHHIIYRDFKASNILLDGEFNAKLSDFGLAKAGPTGDKTHVSTQVMGTQGYAAPEYVATGRLTSKSDVYSFGVVLLELLS-GRRAvdkdkfgveqnlvdwaKPYMgDKRKVFRIMDTKLEGQYPQKAAHTAATIALQCLSREPKLRPNMTEVLSTL + lGeG fG V++g ++ ++ + + +avK+lk e + ++e l+e++ + +l+h+n+vkl+g c++++ l+v e++++G+L+++L ++ ++l+ + +++a++ A+G+++L++ ++++ rd a N+Ll+ + +k+sDfGLa++ + d+++++++ + apE + ++++tsksDv+sfGv+l E+++ g++ p + ++++v++ ++++ + + p+k+ ++ +++ qC++++p+ Rp+++e++++l kklGeGafGeVvegtlkg.....ekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLes..kklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep................ypgl.sneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 164.3 2e-50 Protein tyrosine kinase 522 Cluster-2021.0-1F PF00069.22 104 379 4 260 DSLLGEGGFGYVFKGwidantltaTRPGSGLVIAVKKLKPEGFQGHKE--WLTEVNYLGQLHHRNLVKLIGYCSEGDYRLLVYEFMPKGSLENHLFRRGPqpLNWATRIKVAIDAARGLSFLHeaEHHIIYRDFKASNILLDGEFNAKLSDFGLAKAGPTGDKthvSTQVMGTQGYAAPEYVATGRLTSKSDVYSFGVVLLELLSGRRAVDKDKF--GVEQNLVDwakpyMGDKRKVFRimDTKLEGQYPQKAAHTAATIALQCLSREPKLRPNMTEVLS ++ lGeG+fG V+k+ ++ +g +AvKk+k e + ke l+E+++l +l+h+n+v+l+++++e d+++lv e++++g+l+++l r+g l+ ++ k+a ++gl++lH +++ii+rD K +NiL+d + + K++DFGlak ++ k t+++gt+ Y APE + + + ++k+Dv+s Gv+l+ell+g+ ++k ve++l + + +k+++ +tk++ + +++ ++a + ++l+++pk R+ ++e+l+ leklGeGsfGkVyka.........veketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgs..lseeeakkiakqilegleylH..skgiiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldq.....lekilkilg..etkeklpeaselseeakdllkkllkkdpkkRltaeellq 151.6 1.7e-46 Protein kinase domain 522 Cluster-2078.0-0R RLK-Pelle_DLSV 1 132 58 190 LGYCIHGIEKLLVYEYVVNESLDNLLFKSGKREVLDWKRRSDIITGVAKGLLYLHEDAHCRIIHRDIKGSNILLDDKWVPKIADFGMARLYPENETHVNT-RVAGTNGYMAPEYVMHGRLSVKADVFSFGVVV lg+ci+g ekllvyey+ n+sLd++lf++ k++ ldWk+r +ii+g+a+GllYLhe+++++iihrD+K sNiLLd+++ pkiaDFG+arl+ e++t+++t rv+gt gYmaPey+++g+ls+k+Dv+sfGv+v lgcciegeekllvyeylenksLdkflfdeekkkeldWktrfkiikgiarGllYLheesrlkiihrDlKasNiLLdkemnpkiaDFGlarlfeedqteastkrvvgtlgYmaPeyalegqlseksDvysfGvlv 215.1 8.1e-66 RLK-Pelle_DLSV 132 Cluster-2078.0-0R PF00069.22 11 132 74 187 LLVYEYVVNESLDNLLFksgKREVLDWKRRSDIITGVAKGLLYLHEDAhcrIIHRDIKGSNILLDDKWVPKIADFGMARLYPENEThvNTRVAGTNGYMAPEYVMHGRLSVKADVFSFGVVV +lv eyv +++l++ll ++ +l+ ++ ++i++ +++gl ylH+ iiHrD+K +NiL+d+k + Ki+DFG+a+ + ++++ t + gt Y+APE + + + s k+Dv+s Gv++ ylvleyveggeladlls...rkgslseeeakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvil 100.7 5.7e-31 Protein kinase domain 132 Cluster-2078.0-0R PF07714.14 1 132 67 196 LGYCIHGIEKLLVYEYVVNESLDNLLFKSGKREVLDWKRRSDIITGVAKGLLYLHEDAhcrIIHRDIKGSNILLDDKWVPKIADFGMARLY-PENETHVNTRVAGTNGYMAPEYVMHGRLSVKADVFSFGVVV lg c+++ + l+v eyv + +L++ L k+ ++e l+ k+ ++++ +AkG+ yL++ ++Hrd+ N+Ll+++ v ki+DfG+ar ++e++++++ +mapE ++++++++k+Dv+sfGv++ lgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvll 95.9 1.6e-29 Protein tyrosine kinase 132 Cluster-2084.0-1R CAMK_CAMKL-CHK1 105 177 1 73 YDLGRLLGHGTFAKVYHARNLQTGKSVAMKVVAKEKVLRVGMTEQIKREISVMKMMKHPNIVELHEVMASKTK y+lGrllG+gtfakv++ar+l+tg+sva+kv+ kekvl+ +++eqikreisv+k+++hpn+v+l+ev+a+k+k yelGrllGegtfakvklardletgesvaikvldkekvlkaklveqikreisvlklvrhpnvvrllevlatksk 102.4 2e-31 CAMK_CAMKL-CHK1 177 Cluster-2084.0-1R PF00069.22 105 176 1 71 YDLGRLLGHGTFAKVYHARNLQTGKSVAMKVVAKEKVLRVGMtEQIKREISVMKMMKHPNIVELHEVMASKT y + lG G+f+kVy a++ +tgk vA+K++ kek +++ rEi+++k +khpniv+l ev+ +k+ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekd 55.2 4.3e-17 Protein kinase domain 177 Cluster-2084.0-1R PF07714.14 107 174 3 72 LGRLLGHGTFAKVYHARNL----QTGKSVAMKVVAKEKvlRVGMTEQIKREISVMKMMKHPNIVELHEVMAS lg+ lG+G+f++V++++ ++ +va+K++ +e+ + +e++ +e+++mk +khpniv+l+ v+ + lgkklGeGafGeVvegtlkgekekkevkvavKtlkeea..teeekeefleeakimkklkhpnivkllgvctk 33.5 1.7e-10 Protein tyrosine kinase 177 Cluster-2084.1-0F CAMK_CAMKL-CHK1 1 185 71 256 KTKIYFSMELVRGGELFAKIAR-GRLREDAARNYFQQLISAIDFCHSRGVYHRDLKPENLLLDEEGNLKVTDFGLSTFSDHLRQDGLLHTACGTPAYVAPEVIGKKGYDGAKADIWSCGVILFALLAGYLPFRDDNIVSLYRKIYKGDFKCPPWFSPEARKLIAKMLDPRPSTRITIAKIMESTWF k+kiy+ +e+v+GGelf+kia+ grl+ed+ar+yfqqlisa+d+chsrgvyhrdlkpenlllde+gnlkv+dfGls+++++lr+dgllht+cGtPayvaPev+ kkgydgakad+WscGvilf llagylPf+d+n+v+lyrki+k++fk+p+w+s+ea+kli+++ldp p+triti++i+e++Wf kskiylvleyvkGGelfekiakkgrlkedearkyfqqlisavdychsrgvyhrdlkpenllldekgnlkvsdfGlsalaeqlredgllhttcGtPayvaPevlkkkgydgakadvWscGvilfvllagylPfedenlvelyrkilkaefklpkwlskeakklisrlldpnpetritieeileeeWf 327.8 3.4e-100 CAMK_CAMKL-CHK1 388 Cluster-2084.1-0F PF00069.22 2 185 71 264 TKIYFSMELVRGGELFAKIA-RGRLREDAARNYFQQLISAIDFCHSRGVYHRDLKPENLLLDEEGNLKVTDFGLSTFSDHLRQdglLHTACGTPAYVAPEVIGKKGYdGAKADIWSCGVILFALLAGYLPFRDDNIVSLYRKI-------------YKGDFKCPPWFSPEARKLIAKMLDPRPSTRITIAKIMESTWF +++y+ +e+v+ggel+ + +g l e+ a+++++q++++++++Hs+g+ HrDlKpeN+L+de+g+lK+tDFGl++ ++ + l++ +gt+ Y+APEv+++++y ++k+D+Ws+Gvil+ ll+g pf++++ + ++k+ +k +++ + +s+ea++l+ k+l+ p++R+t+++++++ ++ delylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeney.skkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 175.3 1e-53 Protein kinase domain 388 Cluster-2084.1-0F PF07714.14 3 181 75 258 KIYFSMELVRGGELFAKIARG----RLREDAARNYFQQLISAIDFCHSRGVYHRDLKPENLLLDEEGNLKVTDFGLSTFSDHLRQDGLLHTACGTPAYVAPEVIGKKGYDgAKADIWSCGVILFALLA-GYLPFRDDNIVSLYRKIYKGD-FKCPPWFSPEARKLIAKMLDPRPSTRITIAKIME ++++ +e+v+gG+L + + +l+ + ++ +q+ +++++ +s+ + Hrdl N Ll+e+ k++DfGL+ + + ++a ++apE++ +k + k+D+Ws Gv+l+ ++ g p+++ + ++++k+ +g ++p ++e +l+ + ++ +p+ R t+++++e pllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkft.sksDvWsfGvllwEiftlgeepypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelve 71.6 4.1e-22 Protein tyrosine kinase 388 Cluster-2096.0-1R RLK-Pelle_RLCK-IXb 1 132 121 252 KPANILLDRNYVSKIGDVGLARLVPPSVSDSVTQYRMTSTAGTFCYIDPEYQQTGMLGVKSDIYSLGIIFLQLLTGKPPMGLTHYVGRAIEKETFRDMLDPTVPDWPYEEALSLAKLALKCSELRRKDRPDL kpanilld+n+vsk++dvGlarl++ +v++++t++++ts+agt++yidpeyq+tg+l +ksD+y+lGii+Lqlltgk+p+gl++ v +a+ek++++++ld+++ dwp+eea +laklal+c+elrrkdRPdl kpanilldenlvsklsdvGlarllkeavaeaatelketslagtlayidpeyqrtgeltpksDvyalGiilLqlltgksplglakkveealekkklkevldksagdwpveeaeklaklalrcaelrrkdRPdl 180.4 3.7e-55 RLK-Pelle_RLCK-IXb 162 Cluster-2096.0-1R PF00069.22 1 132 125 255 KPANILLDRNYVSKIGDVGLARLVPPSVSdsvtqyrMTSTAGTFCYIDPEYQQTGMLGVKSDIYSLGIIFLQLLTGKPPMG---LTHYVGRAIEK-ETFRDMLDPTVPDWPYEEALS--LAKLALKCSELRRKDRPDL Kp+NiL+d++ + Ki+D Gla+ + s + +ts gt Y+ PE ++ + + k+D++slG+i+++lltgkpp+ ++ v + +++ e+++++l++t ++p ++ ls + +l k+ + +k+R+ KpeNiLidekgelKitDFGlakelesssk.......ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRlta 62.4 2.7e-19 Protein kinase domain 162 Cluster-2096.0-1R PF07714.14 4 136 134 257 NILLDRNYVSKIGDVGLARLVppsVSDSVTqYRMTSTAGTFCYIDPEYQQTGMLGVKSDIYSLGIIFLQLLT-GKPPmglthYVGRaIEKETFRDMLDPTVPDWPYEEALSLAKLALKCSELRRKDRPDLGKVV N+Ll++n v ki+D GLar + +d+ + ++ +++ + ++ pE +++ + +ksD++s G++ ++t g+ p y g ++e+++ + + + + p + +l++l +C e + ++Rp++ ++v NvLlsenkvvkisDfGLardi...ekddey.kkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep.....ypgl.sneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelv 42.8 2.5e-13 Protein tyrosine kinase 162 Cluster-2137.0-0F RLK-Pelle_RLCK-VIIa-2 115 388 2 275 LLGEGGFGYVFKGWIDANTLTATRPGSGLVIAVKKLKPEGFQGHKEWLTEVNYLGQLHHRNLVKLIGYCSEGDYRLLVYEFMPKGSLENHLFRRGPQPLNWATRIKVAIDAARGLSFLHEAEHHIIYRDFKASNILLDGEFNAKLSDFGLAKAGPTGDKTHVSTQVMGTQGYAAPEYVATGRLTSKSDVYSFGVVLLELLSGRRAVDKDKFGVEQNLVDWAKPYMGDKRKVFRIMDTKLEGQYPQKAAHTAATIALQCLSREPKLRPNMTEVLS llGeGgfG v+kg+id++t +++++g+gl++avkkl++eg+qghkewl+ev++Lgql+h+nlvkliGyc e d rllvyE+m+kgslenhlfrr ++l W+tr+k+a++aA+gl+fLheae+++iyRdfkasniLld +fnaklsdfglak+gp++dkthvst+vmgt+gYaaPeyvatG+lt+ksDvysfGvvllell+Grra+dk + eq+lvdwa+p++ dkrk+ ri+D++legqy++kaa+++a++al+Cls+epk Rp+m+ev++ llGeGgfGsvykgvidektkaelkageglavavkklnkeglqghkewlaevefLgqlshpnlvkliGycledderllvyEymakgslenhlfrrssealsWetrlkialgaAkglafLheaekkviyRdfkasniLldedfnaklsdfglakegpeedkthvstrvmgtygYaaPeyvatGhltaksDvysfGvvllelltGrraldkkrpkeeqklvdwarpllsdkrkleriiDprlegqysakaaqkvaklalkClskepkeRpkmsevve 455.6 3.9e-139 RLK-Pelle_RLCK-VIIa-2 531 Cluster-2137.0-0F PF07714.14 114 390 5 260 SLLGEGGFGYVFKGWIDAntltaTRPGSGLVIAVKKLKPEGFQG-HKEWLTEVNYLGQLHHRNLVKLIGYCSEGDYRLLVYEFMPKGSLENHLFRR-GPQPLNWATRIKVAIDAARGLSFLHEaeHHIIYRDFKASNILLDGEFNAKLSDFGLAKAGPTGDKTHVSTQVMGTQGYAAPEYVATGRLTSKSDVYSFGVVLLELLS-GRRAvdkdkfgveqnlvdwaKPYMgDKRKVFRIMDTKLEGQYPQKAAHTAATIALQCLSREPKLRPNMTEVLSTL + lGeG fG V++g ++ ++ + + +avK+lk e + ++e l+e++ + +l+h+n+vkl+g c++++ l+v e++++G+L+++L ++ ++l+ + +++a++ A+G+++L++ ++++ rd a N+Ll+ + +k+sDfGLa++ + d+++++++ + apE + ++++tsksDv+sfGv+l E+++ g++ p + ++++v++ ++++ + + p+k+ ++ +++ qC++++p+ Rp+++e++++l kklGeGafGeVvegtlkg.....ekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLes..kklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep................ypgl.sneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 164.3 2.1e-50 Protein tyrosine kinase 531 Cluster-2137.0-0F PF00069.22 113 388 4 260 DSLLGEGGFGYVFKGwidantltaTRPGSGLVIAVKKLKPEGFQGHKE--WLTEVNYLGQLHHRNLVKLIGYCSEGDYRLLVYEFMPKGSLENHLFRRGPqpLNWATRIKVAIDAARGLSFLHeaEHHIIYRDFKASNILLDGEFNAKLSDFGLAKAGPTGDKthvSTQVMGTQGYAAPEYVATGRLTSKSDVYSFGVVLLELLSGRRAVDKDKF--GVEQNLVDwakpyMGDKRKVFRimDTKLEGQYPQKAAHTAATIALQCLSREPKLRPNMTEVLS ++ lGeG+fG V+k+ ++ +g +AvKk+k e + ke l+E+++l +l+h+n+v+l+++++e d+++lv e++++g+l+++l r+g l+ ++ k+a ++gl++lH +++ii+rD K +NiL+d + + K++DFGlak ++ k t+++gt+ Y APE + + + ++k+Dv+s Gv+l+ell+g+ ++k ve++l + + +k+++ +tk++ + +++ ++a + ++l+++pk R+ ++e+l+ leklGeGsfGkVyka.........veketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgs..lseeeakkiakqilegleylH..skgiiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldq.....lekilkilg..etkeklpeaselseeakdllkkllkkdpkkRltaeellq 151.5 1.8e-46 Protein kinase domain 531 Cluster-2194.0-1R STE_STE11 2 83 174 255 EQGFPADIWALGCTVIEMATGRSPWPNLSQPSSLLYRIALSDELPEFPSFLSDKAKDFLSKCLRRGPKERWSAKQLIKHPFL e+g+ aDiw+lGCtV+em+tg++pw++l++ + l++i+ s+elPe+p+ ls++akdFlskCl+r p+eR++a++L++hpFl elglaaDiwslGCtVlemltgkapwseleeevaalfkigkskelPeipeslseeakdFlskClqrdpaeRptaaeLLehpFl 110.9 6.2e-34 STE_STE11 183 Cluster-2194.0-1R PF00069.22 4 83 175 264 GFPADIWALGCTVIEMATGRSPWPNLSQPS---------SLLYRIA-LSDELPEFPSFLSDKAKDFLSKCLRRGPKERWSAKQLIKHPFL + ++D+W+lG++++e+ tg+ p+++ ++ + +++i ++e + +s ls++akd+l+k+l++ pk+R++a++l++hp+l skkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 52.9 2.2e-16 Protein kinase domain 183 Cluster-2194.0-1R PF07714.14 7 79 187 258 ADIWALGCTVIEMAT-GRSPWPNLsQPSSLLYRIaLSDELPEFPSFLSDKAKDFLSKCLRRGPKERWSAKQLIK +D+W+ G +++E++t g++p+p+l +++++l ++ +++ e p+ +++ ++++++C+++ p+eR + k+l++ sDvWsfGvllwEiftlgeepypgl.sneevlekl.kegkrlekpekcpeelyelmkqCweedpeeRptfkelve 27.4 1.2e-08 Protein tyrosine kinase 183 Cluster-2292.0-0R NAK 5 139 128 262 YRDLKAENLLLGSDGLWKLCDFGSTTTNHKRFDKPEEMGIEEDNIRKHTTPAYRSPEMWDLFRKEVINEKVDIWALGCLLFRICYFKLAFDGESKLQVLNGNYRIPDLPKYSKSITDLIKDMLQSSPNDRPDITQ +rdlkaen+Llg++gl++l+Dfgs++t++k +d++ee+++eed+irkhtt+ayr+Pe+Wdl+++e+i+ekvDiWaLGclL++i+y+k +fdGeskl++lng+++iP+ pky++++++likdmLq+sp++rPdi++ hrdlkaenvLlgqeglavlmDfgsartarkeldsreealaeedvirkhttaayraPelWdlysredidekvDiWaLGclLyaimygkspfdGesklailngklkiPespkypdalrqlikdmLqaspavrPdidd 221.1 1.4e-67 NAK 229 Cluster-2292.0-0R PF00069.22 4 140 120 258 LYRDLKAENLLLGSDGLWKLCDFGSTTTNHKRFDkpeemgieedNIRKHTTPAYRSPEMWdlfRKEVINEKVDIWALGCLLFRICYFKLAFDGESKLQ----VLNG-----------NYRIPDLPKYSKSITDLIKDMLQSSPNDRPDITQA ++rDlK eN+L+ ++g K++DFG + +++ + t+ Y++PE+ +++ + +kvD+W+lG++l+ + + k f ge++ + l+ + +p + s++++dl+k++l+ p++R+ ++++ iHrDlKpeNiLidekgelKitDFGlakelesssk..........ltsfvgtreYlAPEvl...keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeel 76.8 1.1e-23 Protein kinase domain 229 Cluster-2292.0-0R PF07714.14 5 139 127 255 YRDLKAENLLLGSDGLWKLCDFGSTTTNHKRFDKpeemgieEDNIRKHTTPAYRSPEMWdlfRKEVINEKVDIWALGCLLFRICY-FKL---AFDGESKLQVLNGNYRIPDLPKYSKSITDLIKDMLQSSPNDRPDITQ rdl a N Ll ++ + k++DfG + + +k+ + +++ ++++ + +pE++ +++++++k D+W+ G ll+ i+ + ++ e+ l+ l+ ++r++ k ++++++l+k+ ++++p++Rp++++ HrdlaarNvLlsenkvvkisDfGLardiekddey.......kkkeeaklpvkWmapEsl...kekkftsksDvWsfGvllwEiftlgeepypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfke 44.0 1.1e-13 Protein tyrosine kinase 229 Cluster-2322.0-0F TKL_CTR1-DRK-1 1 121 124 245 KSANCLVNKHWTVKICDFGLSRIMTDETMSDSSSAGTPEWMAPELIRNEPFTVKCDIFSLGVIMWELCTLSKPWEGVPPERVVYAVANEGLRLEIPEGPLGRIIADCWAE-PHERPSCDEIL ksan+l++k+wtvkicdfglsr++++++++d++saGtpew+apel+rn++++ k+d+fslGvi+wel+tl++pweg++p++vv++va+++ rleip+g+lg++iadcw+e p++rps++eil ksanllldkrwtvkicdfglsrvlsrsavkdeasaGtpewqapellrnkeyaektdvfslGvilwelvtlqrpweglepvkvveevatknarleipdgalgkliadcwkedpesrpsleeil 206.5 3.5e-63 TKL_CTR1-DRK-1 121 Cluster-2322.0-0F PF07714.14 3 120 133 256 ANCLVNKHWTVKICDFGLSRIM--TDETMSDSSSAGTPEWMAPELIRNEPFTVKCDIFSLGVIMWELCTL-SKPWEGVPPERVVYAVaNEGLRLEIPE---GPLGRIIADCWA-EPHERPSCDEI N+L++++ +vki+DfGL+r + +de+ +++++ +WmapE ++++ ft+k D++s Gv++wE++tl ++p++g+ +e+v+ ++ +eg rle pe l +++ +Cw+ +p+eRp+ +e+ rNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevlekl.kegkrlekpekcpeelyelmkqCweedpeeRptfkel 96.2 1.2e-29 Protein tyrosine kinase 121 Cluster-2322.0-0F PF00069.22 1 84 125 207 KSANCLVNKHWTVKICDFGLSRIMTDETMsDSSSAGTPEWMAPELIRNEPFTVKCDIFSLGVIMWELCTLSKPWEGVPPERVVY K++N L++++ +Ki+DFGl++ ++ ++ +s gt+e++APE++++++++ k+D++slGvi++el t p++g + v+ KpeNiLidekgelKitDFGlakelesssk.ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekve 74.9 4.2e-23 Protein kinase domain 121 Cluster-2344.0-1R WNK_NRBP 2 174 66 239 WKDKEKNTLNFITEACA-ANLREYRKKHRHVSMKAIKKWSRQILKGLDYLHTHEPCVIHRDLNCSNIFINGNVGKVKIGDLGLATIVGKSHAAHSLLGTPEYMAPELYEENYTELVDIYSFGMCLLEMDTLEIPYSECDNLVKIYKKVTTGVMPQAMKKVSDPELKAFIERCVG W d++k+t+n+ite ++ +Lr+yrkkh++v++ka+kkw+rqilkgL+yLh+++P++ihrdl+C+nif+nGn G+vkigdlGla+++ +++aa+s+lGtpe+maPelyee+y+elvdiysfGmclle+ tle+Pysec+n ++iykkvt+g+ p+a++kv+d+e+++fie+c+ WvdekkktvnlitelftsGtLrqyrkkhkkvdlkavkkwarqilkgLeyLhskdPpiihrdlkCdnifvnGnsGevkigdlGlaavlreakaaksvlGtpefmaPelyeeeynelvdiysfGmcllelvtleyPysecknaaqiykkvtsgkkpaalekvkdaevrkfiekcla 295.1 3.7e-90 WNK_NRBP 176 Cluster-2344.0-1R PF00069.22 6 173 69 245 EKNTLNFITEACAAN-LREYRKKHRHVSMKAIKKWSRQILKGLDYLHTHEpcVIHRDLNCSNIFINgNVGKVKIGDLGLATIVGKSHAAHSLLGTPEYMAPELY-EENYTELVDIYSFGMCLLEMDTLEIPYS----------ECDNLVKIYKKVTTGVMPQAMKKVSDPELKAFIERCV ek++l +++e + + l ++ +++ ++s++ +kk+ +qil+gl+ylH ++ +iHrDl +Ni+i+ + g++Ki+D+Gla+ + +s+ ++s gt+eY+APE+ e++y++ vD++s G+ l+e+ t + p+s e+d+l+ki+k +++ + + ++ ++e+k ++++++ ekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskg..iiHrDlKpeNiLid.ekgelKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkll 120.0 7.5e-37 Protein kinase domain 176 Cluster-2344.0-1R PF07714.14 8 173 74 243 NTLNFITEACAA-NLREYRKKH---RHVSMKAIKKWSRQILKGLDYLHTHEpcVIHRDLNCSNIFINGNVgKVKIGDLGLATIV---GKSHAAHSLLGTPEYMAPELYE-ENYTELVDIYSFGMCLLEMDT-LEIPYSECdNLVKIYKKVTTGVMPQAMKKVsDPELKAFIERCV ++l ++te ++ +L+++ +k+ +++++k + ++++qi kG++yL+ ++ ++Hrdl + N++++ n +vki+D GLa + + ++ ++ ++mapE + +++t+ D++sfG++l E+ t e py+++ + ++++k+++g ++ +k+ +el+ ++++C+ epllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskk..lvHrdlaarNvLlsenk.vvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypgl.sneevleklkegkrlekpekc.peelyelmkqCw 86.3 1.3e-26 Protein tyrosine kinase 176 Cluster-2489.3-0R RLK-Pelle_L-LEC 241 342 3 104 QILGSDNRSVTYKTTLLN-GCNTVVKRFSGEYFAShgldKRRMHKEIKAISKIRHPNLVPIRGWCFDHQETIVVYDYIPNGSLDKWLF---GVGVLPWTRRFRVVK ++lG+ + + Yk +l + g + vKr+s e + +++ +e+k+is++rh nlV+++Gwc +++e ++vy+y+pngsldk+Lf vl+w++R+++vk ellGeggfGkvYkgvlkskgrevAvKriskeskqg....ekeFvaevkiisrlrhrnlVkLlGwcrekkelllvyeympngsldklLfkeeeeavlsweqRykivk 73.4 1.6e-22 RLK-Pelle_L-LEC 342 Cluster-2489.3-0R PF07714.14 259 326 28 92 GCNTVVKRFSGEYFASHgldKRRMHKEIKAISKIRHPNLVPIRGWCFDHQETIVVYDYIPNGSLDKWL ++ +vK ++ e+ +++ k+++ +e+k ++k++hpn+v + g+c +++++++v +y+++G+L+k L evkvavKtlkeeateee...keefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfL 30.7 1.2e-09 Protein tyrosine kinase 342 Cluster-2498.0-0R RLK-Pelle_L-LEC 1 104 161 266 VLGTMGYIAPECFHTGKATQQSDVFAFGAVLLEVVCGLRPGSK--VAGFQFLVDWVWFLHRDGRLLEAVDPILGGEFVGGEAERLLLLGLACSHPSASERPKTQTI v gt+gY+ape+++tgkat++sDV++FG+vlLevvcg rp +k ++lvdwv+ l+++g+lleavd l +ef e+er+l lgl+cs++++++Rp+ +++ vagtlgYlapelvktgkattesDVysFGvvlLevvcgrrpvekeaeeeevllvdwvlelakkgklleavderlkeefdeeevervlklgllcsksdpekRpsmkev 104.9 3.8e-32 RLK-Pelle_L-LEC 214 Cluster-2498.0-0R PF07714.14 6 46 171 212 GYIAPECFHTGKATQQSDVFAFGAVLLEVVC-GLRPGSKVAG ++apE+++++k t++sDv++fG +l E+++ g +p +++ kWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsn 27.2 1.4e-08 Protein tyrosine kinase 214 Cluster-2498.1-0R RLK-Pelle_L-LEC 136 302 2 166 KNKLGQGGYGVVYKGFLAKEDLDIAVKWFSRESIKGQVDFLAELTIINRLRHKHLVKLLGWCYKNGKLLLVYEYMPNGSLDKHLFSDTDVEPLGWSLRYKIVSGVASALHYLHNEFEQRVVHRDLKASNIMLDSNFDSRLGDFGLARALDNGKTsyAEAEGVLGTMG +++lG+gg+G vYkg+l +++ ++AvK +s+es +g+ +F+ae++ii+rlrh+ lVkLlGwc ++++lllvyeympngsldk+Lf++++ + l w+ Rykiv+g+asaL+yLH+e eq v+hrd+kasn++LD++f +rLgDFGlar ld+gk+ ++++ v gt+g eellGeggfGkvYkgvlkskgrevAvKriskeskqgekeFvaevkiisrlrhrnlVkLlGwcrekkelllvyeympngsldklLfkeeeeavlsweqRykivkgiasaLlyLHeeleqvvlhrdikasnvlLDeefnarLgDFGlarlldhgke..pqttrvagtlg 233.6 2.1e-71 RLK-Pelle_L-LEC 302 Cluster-2498.1-0R PF00069.22 134 291 2 154 DEKNKLGQGGYGVVYKGFLAKEDLDIAVKWFSRESIKGQVD--FLAELTIINRLRHKHLVKLLGWCYKNGKLLLVYEYMPNGSLDKHLFSDTDVEPLgwsLRYKIVSGVASALHYLHNEFeqrVVHRDLKASNIMLDSNFDSRLGDFGLARALDNGKTsY +++klG+G++G+Vyk++ ++++ +AvK +++e++k + + +l+E++i+++l+h+++v+l+++++++ +l+lv ey+++g+l+++l ++ +++ ki++ ++++l+ylH++ ++HrDlK +Ni++d++ + +++DFGla+ l+++++ + ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslsee...eakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk.l 122.4 1.4e-37 Protein kinase domain 302 Cluster-2498.1-0R PF07714.14 136 293 4 163 KNKLGQGGYGVVYKGFLA----KEDLDIAVKWFSRESIKG-QVDFLAELTIINRLRHKHLVKLLGWCYKNGKLLLVYEYMPNGSLDKHLFSDTDVEPLGWSLRYKIVSGVASALHYLHNefeQRVVHRDLKASNIMLDSNFDSRLGDFGLARALDNGKTSYAE ++klG+G +G V++g l k+++++avK +++e+ + + +fl e++i+++l+h+++vkllg+c+k+++ll+v ey+++G+L+k+L ++++ e+l + ++++ +A++++yL++ +++vHrdl a N++l++n +++DfGLar++ + ++ +++ gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLes...kklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkk 118.7 1.7e-36 Protein tyrosine kinase 302 Cluster-2630.1-1F RLK-Pelle_RLCK-IXb 130 381 2 252 KIGEGGYGSIYRGVLRHTPVAIKMLHPNSSQGPLEFQQEVNILSRLRHPNLVTLIGACPEAWVLVYEYLPNGSLEDRLGCKNNTPPLSWQTRIRIAAEICSILICLHSCRPHCIVHGDLKPANILLDSNLVSKLSDFGICRLLSeDEYSDNNTICCKTEPKGTFVYMDPEFLSTGELTPKSDVYSFGIILLRLLTGMPALRITKEVQYALDKENLKNLLDATAGDWPFVQAKQLAHLAMRCCEVDRGRRPDL kiGeggyg++Y+g l+ht+va+k+l+++s+qg efqqev++ls++rHpnlv+L+Gacpea +LvYeylpnGsLedrL +k+n++plsW++r+riaaei+s L+ LHs++p+ ivH+dlkpanilld+nlvsklsd+G++rll+ ++ ++++t +++t+++gt++y+dpe+ +tgeltpksDvy++GiilL+lltg+++l+++k+v+ al+k++lk++ld++agdwp+ +a++la+la+rc+e++r +RPdl kiGeggygkvYkgkldhtevavkvlkedslqgekefqqevevlskirHpnlvlLlGacpeagaLvYeylpnGsLedrLlrkknskplsWeervriaaeiasaLlfLHsakpepivHrdlkpanilldenlvsklsdvGlarllk.eavaeaatelketslagtlayidpeyqrtgeltpksDvyalGiilLqlltgksplglakkveealekkklkevldksagdwpveeaeklaklalrcaelrrkdRPdl 372.7 7.7e-114 RLK-Pelle_RLCK-IXb 547 Cluster-2630.1-1F PF00069.22 129 380 5 254 LKIGEGGYGSIYRGV--LRHTPVAIKMLHPNSSQGPL--EFQQEVNILSRLRHPNLVTLIGACP--EAWVLVYEYLPNGSLEDRLGckNNTPpLSWQTRIRIAAEICSILICLHSCRphcIVHGDLKPANILLDSNLVSKLSDFGICRLLSEDEYsdnnticcKTEPKGTFVYMDPEFLSTGELTPKSDVYSFGIILLRLLTGMPALR---ITKEVQYALDK-ENLKNLLDATAGDWPFVQ--AKQLAHLAMRCCEVDRGRRPD k+GeG++G++y++v ++ vA+K++ ++ + ++++E++il +l+hpn+v+l++++ + +lv ey+++g+l+d+l +++ ls ++ +ia++i++ l lHs + i+H DlKp+NiL+d++ + K++DFG+++ l++++ +t+ gt Y+ PE l++ e ++k+Dv+s G+il+ lltg p ++ +++v+ ld+ e++ ++l+ t ++p + +++ +l +++++d+ +R+ eklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls..rkgs.lseeeakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk........ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRlt 144.0 3.6e-44 Protein kinase domain 547 Cluster-2630.1-1F PF07714.14 130 381 6 253 KIGEGGYGSIYRGVLR------HTPVAIKMLHPNSSQG-PLEFQQEVNILSRLRHPNLVTLIGACP--EAWVLVYEYLPNGSLEDRLGCKNNTPPLSWQTRIRIAAEICSILICLHSCRphcIVHGDLKPANILLDSNLVSKLSDFGICRLLSEDEYSdnntiCCKTEPKGTFVYMDPEFLSTGELTPKSDVYSFGIILLRLLT-GMPAlritkeVQYALDKENLKNLLDATAGDWPFVQAKQLAHLAMRCCEVDRGRRPDL k+GeG +G++++g l+ ++ va+K+l+ ++++ ef +e++i+++l+hpn+v l+g+c e ++v ey+++G+L++ L k+++++l+ ++ +++a++i++ + L+s + +vH dl N+Ll++n v k+sDfG++r +++d++ k+e k + +m pE l+++++t ksDv+sfG++l ++t g ++ ++e l++l + + + p ++l++l ++C+e d +Rp++ klGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLardiekddey.....kkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep......ypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptf 139.9 5.8e-43 Protein tyrosine kinase 547 Cluster-2641.0-0F RLK-Pelle_PERK-1 1 162 101 262 IGAARGIAYLHEDCHPRIIHRDIKSSNILLDNNLEARVSDFGLAKLAIDTNTHITTRVMGTFGYMAPEYASSGKLTEKSDVFSFGVVLLELITGRKPVDTSQPLGDESLVEWARPLLSHALETEAFDDLADPRLERNYVDSEMFRLIEVAAACIRHSAAKRP +gaa+g+aylhedchP+iihrdik++nilld++ ea+v+dfGlakla dtnth++trvmGtfGy+aPeyassGklt+ksdvfsfGvvllelitGrkpvd+s++l++eslvewarpll++ale++ fd+l+d+rle++y ++e++r+ie+aaa++rhsa+krp lgaakglaylhedchPkiihrdikaanilldekfeakvadfGlaklasdtnthvstrvmGtfGylaPeyassGkltdksdvfsfGvvllelitGrkpvdaseelaeeslvewarpllakaleegdfdelvdkrlekkydekelarmieaaaaavrhsakkrp 292.1 2.6e-89 RLK-Pelle_PERK-1 162 Cluster-2641.0-0F PF00069.22 4 104 108 203 ARGIAYLHEDChprIIHRDIKSSNILLDNNLEARVSDFGLAKLAIDTNThiTTRVMGTFGYMAPEYASSGKLTEKSDVFSFGVVLLELITGRKPVDTSQPL ++g++ylH+ + iiHrD+K++NiL+d++ e +++DFGlak + +++ +t ++gt Y+APE ++ + ++k+Dv+s Gv+l+el+tg+ p ++ legleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgk 98.2 3.3e-30 Protein kinase domain 162 Cluster-2641.0-0F PF07714.14 3 101 113 210 AARGIAYLHEDchpRIIHRDIKSSNILLDNNLEARVSDFGLAKLA-IDTNTHITTRVMGTFGYMAPEYASSGKLTEKSDVFSFGVVLLELIT-GRKPVDTS A+G++yL++ +++Hrd+ + N+Ll++n +++sDfGLa+ d +++ +++ + +mapE +++k+t+ksDv+sfGv+l E++t g++p+ + iAkGmeyLesk...klvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypgl 84.9 3.5e-26 Protein tyrosine kinase 162 Cluster-2694.0-1F Group-Pl-3 104 360 2 258 VGKQIGSGSFSTVWHARHRIHGTEVAIKEIVTARLNLKLQESLKSEIFILKKINHPNIIRLHDMIEEPDRMYIILEYCKGGDLSMYIQQHLrRIPESTAKHFMQQLAAGLKILRDNNLIHRDLKPQNLLLSSDDENAVLKIADFGFARSLQPRGLAETLCGSPLYMAPEIMQLQKYDAKADLWSVGAILFQIVTGKTPFTGNNQIQLLQNIIKSTELQFPPEA-ENLSPDCVDLCRKLLRRNPVERLTFEEFFNHPYL v++qigsgsf++vw+a+h+ +g+eva+kei ++rln kl+esl+sei il++i+hpniirl+d+iee+d++y++leyc+GGdl++yiq++ +++e++ak+f++qlaaGlk+lr+nn+ihrdlkPqnllls++d++avlkiadfgfarslqp++laetlcGsplymaPe++qlqkydakadlWsvgailfq+vtG++Pf+Gnn++qllqni+kstel+fp e ++l+pdc+dlcrkllr+npverl+feeff+h++l vteqigsgsfavvwkakhkstgeevavkeialerlnkklresleseiailrridhpniirlldlieeedkiylvleyceGGdlaayiqrkg.kveeavakkflrqlaaGlkvlrenniihrdlkPqnlllstnddeavlkiadfgfarslqpeelaetlcGsplymaPevlqlqkydakadlWsvgailfqlvtGrpPfsGnnkvqllqnikkstelkfpeeiladlhpdcidlcrkllrknpverlsfeeffahkfl 445.3 3.9e-136 Group-Pl-3 883 Cluster-2694.0-1F PF00069.22 102 360 1 264 YMVGKQIGSGSFSTVWHARHRIHGTEVAIKEIVTARLNLKLQESLKSEIFILKKINHPNIIRLHDMIEEPDRMYIILEYCKGGDLSMYIQQHLRrIPESTAKHFMQQLAAGLKILRDNNLIHRDLKPQNLLLSSDDEnavLKIADFGFARSLQPRGLAETLCGSPLYMAPEIMQLQKYDAKADLWSVGAILFQIVTGKTPFTGNNQIQLLQNIIKS----------TELQfPPEAENLSPDCVDLCRKLLRRNPVERLTFEEFFNHPYL y + +++G+Gsf++V a+++ g +vA+K+i + + + k ++++ +Ei ilkk++hpni+rl +++ee+d++y++ley++gg+l +++++ ++e++ak++++q+++gl+ l ++++iHrDlKp+N+L+++++e lKi+DFG+a+ l+ + +++ +g++ Y+APE+++ ++y++k+D+Ws+G il++++tgk+pf g+++ + +++++ t+++ pea++ls+++ dl++kll+++p +Rlt+ee +hpyl yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgs.lseeeakkiakqilegleylHskgiiHrDlKpeNiLidekge...lKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkek.lpeaselseeakdllkkllkkdpkkRltaeellqhpyl 245.4 4.1e-75 Protein kinase domain 883 Cluster-2694.0-1F PF07714.14 104 354 3 256 VGKQIGSGSFSTVWHARHR----IHGTEVAIKEIvTARLNLKLQESLKSEIFILKKINHPNIIRLHDMIEEPDRMYIILEYCKGGDLSMYIQQH--LRRIPESTAKHFMQQLAAGLKILRDNNLIHRDLKPQNLLLSSddeNAVLKIADFGFARSL--QPRGLAETLCGSP-LYMAPEIMQLQKYDAKADLWSVGAILFQIVT-GKTPFTGNNQIQLLQNIIKSTELQFPpeaENLSPDCVDLCRKLLRRNPVERLTFEEF +gk++G+G+f++V++++ + + ++va+K + +++ + + +e++ +e+ i+kk++hpni++l+ ++ + ++++i++ey++gGdL+ +++++ +++ ++ +f++q+A+G++ L +++l+Hrdl +N Lls+ n v ki+DfG ar++ + + +++ + p +mapE+++ +k+ k+D Ws G +l+ i+t g++p++g ++ ++l+++ ++++l+ p e+ +++ +l ++ ++++p eR tf+e lgkklGeGafGeVvegtlkgekekkevkvavKtl.keeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlse...nkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevleklkegkrlekp...ekcpeelyelmkqCweedpeeRptfkel 161.7 1.3e-49 Protein tyrosine kinase 883 Cluster-2893.0-2F CMGC_CLK 138 198 1 61 YKIHSKMGEGTFGQVLECWDKERKEMVAIKVIRGVRKYRDAAMIEIEMLQQLGRHDIGGNR yki skmgegtfg+vlecwd+erke+vaikv+r+++kyrdaamiei++l++l+++d g+r ykilskmgegtfgrvlecwdrerkelvaikvvrsikkyrdaamieidvlkklakndklgsr 98.5 2.8e-30 CMGC_CLK 283 Cluster-2893.0-2F PF00069.22 138 192 1 57 YKIHSKMGEGTFGQVLECWDKERKEMVAIKVIRGVRKYR---DAAMIEIEMLQQLGrH y+ ++k+GeG+fG+V+++ +ke++++vA+K+i+ ++ ++++ Ei++l++l h yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklk.h 30.2 1.8e-09 Protein kinase domain 283 Cluster-2959.1-2F TKL-Pl-5 50 297 2 249 ITKGTFRIASWRGTEVAVKTFWE-GFADEDKVKAFRDELDLLQKIRHPNVVQFLGAVTQSSPMMIVTEYLMKGDLREYLKIKGALKPAMALRFAMDIARGMNYLHeNKPEAIIHQDLEPSNILRDDSRHLKVADFGVSKLLKAANRNKENRLLMfHDTSRRYMAPELYRGEEYDTKVDVFSFALILQEMIEGVQPFYAKPENEVPKLYTA-KERPPFRAPAKFYAHGLKELIEECWSEKAAHRPAFKRII +++g++++a+Wrgt+vavk++ e + de+++k+frdEl+lL+k+rHPnvvqFlgAvt+++p+mivteyl kgdL+++lk kg+l+p+ a++fa+diArG++yLH +kp++iiH+dL+p+n+l+d++ +lkvadFg+skllk+++++++ +l +++s rymaPe++r eeyd++vDvfsfalil+e++eg++pf k+++e+ kl++ ++Rp+fra +k y +glkelieecws++a++RP+f++ii gefgevkkakWrgtkvavkvlkeellsdeeaikdfrdElelLeklrHPnvvqFlgAvtkqkplmivteylpkgdLakllkkkgklspsravkfaLdiArGlayLH.ekpdpiiHrdLkpknllldeagelkvadFglskllkvklsedkykltg.etgsyrymaPevfrneeydksvDvfsfalilyelleglkpfaekepeeaaklvalegkRpefraksksypeglkelieecwskeaekRPtfseii 346.8 6.5e-106 TKL-Pl-5 379 Cluster-2959.1-2F PF07714.14 50 300 15 260 ITKGTFR-IASWRGTEVAVKTFwEGFADEDKVKAFRDELDLLQKIRHPNVVQFLGAVTQSSPMMIVTEYLMKGDLREYLKIK---GALKPAMALRFAMDIARGMNYLHENKpeaIIHQDLEPSNILRDDSRHLKVADFGVSKLLKAANRNKENrllMFHDTSRRYMAPELYRGEEYDTKVDVFSFALILQEMIE-GVQPFYAKPENEVPKLYTAKERppFRAPAKFyAHGLKELIEECWSEKAAHRPAFKRIIPRL + +gt + + + ++vavKt+ + a+e++ ++f +e+++++k++hpn+v++lg++t+++p++ivtey+ +GdL+++L+ k +l+ l+fa++iA+Gm+yL+++k ++H+dl N+L +++++ k++DfG+++ ++ ++ k++ ++++ ++mapE + +++ +k Dv+sf +l E+++ g +p+ ++ev + +++++r ++p+k + l+el+++Cw+e++++Rp fk+++ +l VvegtlkgekekkevkvavKtl.keeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLardiekddeykkk...eeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevleklkegkr..lekpekc.peelyelmkqCweedpeeRptfkelvekl 179.9 3.5e-55 Protein tyrosine kinase 379 Cluster-2959.1-2F PF00069.22 59 296 21 258 SWRGTEVAVKTFWEGFADEDKVKAFRDELDLLQKIRHPNVVQFLGAVTQSSPMMIVTEYLMKGDLREYLKIKGALKPAMALRFAMDIARGMNYLHENKpeaIIHQDLEPSNILRDDSRHLKVADFGVSKLLKAANRnkenrlLMFHDTSRRYMAPELYRGEEYDTKVDVFSFALILQEMIEGVQPFYAKPENEVPKLYTA----------KERPPFRAPAKFyAHGLKELIEECWSEKAAHRPAFKRI +++g +vAvK++ + a+++k k+++ E+ +l+k++hpn+v++++++++++ +++v+ey+++g+l ++l+ kg+l+++ a ++a i++g++ylH+++ iiH Dl p+NiL d++++lK++DFG++k l+ ++ l+ +r+Y+APE+ +++ey++kvDv+s ++il e++ g +pf+++ ++e + + +++ ++ + ++ + +k+l++++++++ +R+ ++ + ketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk......ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeasel.seeakdllkkllkkdpkkRltaeel 157.2 3.2e-48 Protein kinase domain 379 Cluster-2987.0-1R TKL-Pl-4 1 123 132 253 LLDTKRTLKIADFGVARVEAQnPKDMTGETGTLGYMAPEVLDGKPYNRKCDVYSFGVCLWEIYCCDLPYPDLSFAEVSSAVVRQNLRPEIPRCCPSAFANIMKKCWDANPEKRPDMDEVVRLL lld+++++KiaDfGvarveaq +++mt+etGt+++maPEvl++kpy+rk+Dvysfg++lWe++++++py dl+++++++avv++nlRpeip+++p+a+a+++++cw+a+pekRp+++e+v+ll lldeekvvKiaDfGvarveaq.seemtaetGtyrwmaPEvlekkpydrkvDvysfgivlWelltgkvpyedltplqaavavvqknlRpeipkevpealaellercwkadpekRpefseivkll 195.5 9.4e-60 TKL-Pl-4 139 Cluster-2987.0-1R PF07714.14 1 123 136 260 LLDTKRTLKIADFGVARVE--AQNPKDMTGETGTLGYMAPEVLDGKPYNRKCDVYSFGVCLWEIYC-CDLPYPDLSFAEVSSAVvRQNLRPEIPRCCPSAFANIMKKCWDANPEKRPDMDEVVRLL Ll+++++ ki+DfG+ar ++ k+ ++++ + +mapE+l+ k ++ k Dv+sfGv+lwEi++ ++ pyp+ls +ev +++ +++ r e p+ cp++++++mk+Cw+++pe+Rp+++e+v+ l LlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevlekl.kegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 110.1 7.3e-34 Protein tyrosine kinase 139 Cluster-2987.0-1R PF00069.22 1 120 130 259 LLDTKRTLKIADFGVARVEAQNPKdMTGETGTLGYMAPEVLDGKPYNRKCDVYSFGVCLWEIYCCDLPYPDLSFAEVSSAVVRQ-----------NLRPEIPRCCPSAFANIMKKCWDANPEKRPDMDEVV L+d+k+ lKi+DFG+a+ ++ k +t ++gt Y+APEvl++++y +k+Dv+s Gv l+e+++ p+++ + e ++ ++q ++ + ++ +++ + +++kk+++ +p+kR+ ++e++ LidekgelKitDFGlakelesssk.ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeell 81.6 3.8e-25 Protein kinase domain 139 Cluster-3053.0-0R CMGC_CK2 86 371 1 286 YEVVRKVGRGKYSEVFEGINVNSNEKCIIKILKPVKKKKIKREIKILQNLCGGPNIVKLLDIVRDQHSKTPSLIFEYVNSTDFKILYPTLTDYDIRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVRVASRYFKGPELLVDLQDYDYSLDLWSLGCMFAGMIFRKEPFFYGHDNQDQLVKIAKVLGTDELNAYLHKYQLELDPQLEALVGRHSRKPWSKFINTDNQHLVSPEAIDFLDKLLRYNHQDRLTAKEAMAHPYF yevvrkvgrgkysevfeginv+++ekc+ikilkpvkkkkikreikilqnl+ggpnivklldivrdq+sktpslifeyvn+tdfk+lyptltdydiryyiyellkaldychs+gimhrdvkphnv+idhe rklrlidwglaefyhpgkeynvrvasryfkgpellvdlqdydysldlwslgcm+ag+ifrkepffyghdn+dqlvkiakvlgtdelnayl+ky+leldpqlealvgrhsrkpwskfin+dnqhlvspea+dfldkllry+hq+rltakea+ahpyf yevvrkvgrgkysevfeginvaneekcvikilkpvkkkkikreikilqnlsggpnivklldivrdqesktpslifeyvnntdfkvlyptltdydiryyiyellkaldychsrgimhrdvkphnvlidhekrklrlidwglaefyhpgkeynvrvasryfkgpellvdlqdydysldlwslgcmlaglifrkepffyghdnydqlvkiakvlgtdelnaylnkyrleldpqlealvgrhsrkpwskfinadnqhlvspealdfldkllrydhqerltakealahpyf 616.1 5.8e-188 CMGC_CK2 476 Cluster-3053.0-0R PF00069.22 86 371 1 264 YEVVRKVGRGKYSEVFEGINVNSNEKCIIKILKPVKKKKIK-----REIKILQNLCgGPNIVKLLDIVRDqhSKTPSLIFEYVNSTDFKILYP---TLTDYDIRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDhELRKLRLIDWGLAEFYHPGKEYNVRVASRYFKGPELLvDLQDYDYSLDLWSLGCMFAGMIFRKEPFFYGHD------NQDQLVKIAKVLGTDELNAYLHKYQleldpqlealvgrhsrkpwskfintdnqhlvSPEAIDFLDKLLRYNHQDRLTAKEAMAHPYF ye+++k+G+G++++V+++++ +++++ +K++k k+kk k rEikil++l pniv+l++++++ +++ l++eyv+ ++++ l+ +l++ +++ +++++l++l+y+Hs+gi+HrD+Kp+N++id e ++l+++D+Gla+ ++ +++++ +v++r++ PE+l + ++y+ + D+WslG++++ ++++k+pf ++ + dql+ki+k+lg+ +++ + s+ea+d+l+kll++++++Rlta+e+++hpy+ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklk.hpnivrlyevfee..kdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLid.ekgelKitDFGlakelessskltsfvgtreYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeasel...............................seeakdllkkllkkdpkkRltaeellqhpyl 219.2 4.1e-67 Protein kinase domain 476 Cluster-3053.0-0R PF07714.14 88 287 3 214 VVRKVGRGKYSEVFEGINV----NSNEKCIIKILKPVKKK----KIKREIKILQNLcGGPNIVKLLDIVRdqHSKTPSLIFEYVNSTDFKI-LYP-----TLTDYDIRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHELrKLRLIDWGLAEFYHPGKEYNVRVASR---YFKGPELLVDLQdYDYSLDLWSLGCMFAGMIFRKEPFFYGHDNQD + +k+G+G+++eV+eg+ +++ k+++K+lk +++ ++ +e+ki+++l pnivkll ++ ++++ +++eyv++ d++ L +lt d+ +++++ k+++y +s+ ++Hrd+ Nv+++++ + ++ D GLa+ + +ey+++ ++ + pE l + + + + D Ws G + ++ + e + g +n++ lgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkkl.khpnivkllgvct..keepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenk.vvkisDfGLardiekddeykkkeeaklpvkWmapEslkekk.ftsksDvWsfGvllwEiftlgeepypglsnee 67.7 6.1e-21 Protein tyrosine kinase 476 Cluster-3105.0-0R CMGC_MAPK 57 105 6 54 PIGKGAYGIVCSALNSETNENVAIKKIANAFDNKIDSKRTLREIKLLRH +iGkG+yg+vcsa+++et+e+vaikki+++f+n+id+kr+lreikllr+ viGkGsygvvcsavdtetgekvaikkiedvfenlidakrvlreikllrr 68.6 4e-21 CMGC_MAPK 105 Cluster-3105.0-0R PF00069.22 58 104 7 53 IGKGAYGIVCSALNSETNENVAIKKIANAFDNKIDSKRTLREIKLLR +G+G++G V +a+++et++ vA+Kki + ++k + k++lrEik+l+ lGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilk 33.1 2.4e-10 Protein kinase domain 105 Cluster-3154.0-0F RLK-Pelle_RLCK-XV 1 172 72 243 YDYMINLSLLSHLHGPHSAECHLDWNRRMNIAVGAAEGIAYLHHYATPHIIHRDIKASNVLLDGNFQAQVADFGFAKFIPDGATHVTTRVKGTLGYLAPEYAMLGKASESCDVYSFGILLLELASGKKPLEKLSSTIKRSITDWALPLALEGKFDELVDSRLNGKYVEEELK ydym nlsllshlhg ++a+++ldw+rr++iavg+ae++aylhh+atP+iihrd+kasnvlld +f+a+vadfG+ak+ipdg+thvtt+vkgtlgylapeyamlGk+sescdvysfG+lllel+sgkkp+e+l+s+ kr+it+wa+pl+ egk++elvd++l++ky+eeelk ydympnlsllshlhgqlaadslldwerrlkiavgsaealaylhheatPkiihrdvkasnvlldeefeakvadfGlaklipdgvthvttkvkgtlgylapeyamlGkvsescdvysfGvlllelvsgkkpierlesaekraitewaeplvkegklkelvdkklkdkydeeelk 293.6 1.1e-89 RLK-Pelle_RLCK-XV 172 Cluster-3154.0-0F PF00069.22 4 139 80 208 MINLSLLSHLHgphsAECHLDWNRRMNIAVGAAEGIAYLHHYAtphIIHRDIKASNVLLDGNFQAQVADFGFAKFIPDGAThvTTRVKGTLGYLAPEYAMLGKASESCDVYSFGILLLELASGKKPLEKLSS--TIKR + + +l ++l+ ++++l+ ++ +ia +eg++ylH+ iiHrD+K +N+L+d + + +++DFG+ak + + + +t + gt YlAPE + s+++Dv+s G++l+el +gk p+++ ++ ++++ veggeladlls....rkgslseeeakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvek 89.9 1.1e-27 Protein kinase domain 172 Cluster-3154.0-0F PF07714.14 3 135 82 212 YMINLSLLSHLHGPhSAECHLDWNRRMNIAVGAAEGIAYLHHYatpHIIHRDIKASNVLLDGNFQAQVADFGFAKFI-PDGATHVTTRVKGTLGYLAPEYAMLGKASESCDVYSFGILLLELAS-GKKPLEKLSS y+ + +Ll++L+ +++ +l+ ++ +++a+ A+G++yL++ +++Hrd+ a NvLl+ n +++++DfG a+ i d ++++++ k + ++apE + +k +++ Dv+sfG+ll E+++ g++p+++ls+ yvegGdLlkfLrkk.eekekltlkdllsfalqiAkGmeyLesk...klvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsn 86.8 9.5e-27 Protein tyrosine kinase 172 Cluster-3227.0-2F CMGC_CDK-CDK8 31 339 1 311 YDVIGKIGEGTYGLVFLAKIKS--NRSKPIAIKKFKQSKDGDGVSPTAIREIMLLREISHENVVKLANVHINHADMSLYLAFDYAEHDLYEIIRHHRDKVNQSINQYTVKSLLWQLLNGLNYLHSNWIIHRDLKPSNILVMGDGEEQGVVKIADFGLARIYQAPLKPLSDNGVVVTIWYRAPELLLGAKHYTSAVDMWAVGCIFAELLTLKPLFQGQEVKGTPNPFQLDQLDKIFKVLGHPTQEKWPTLVNLPHWQSDLQHIQGQKYENAGLYHSVPLSTKNPAYDLLSKMLEYDPRKRLTAAQALEHEYF y+++gkigegtyglv+la+ k +r+++iaikkfkqsk+gdgvsptaireimllrei+hen+vkl nvhin+admslylafdyae+dlyeiirhhr+kv++s+n+ytvksllwqllnglnylhsnwiihrdlkpsnilvmg++ee+g+vkiadfglari+qapl+plsdngvvvtiwyrapelllgakhytsavd+wavgcifaelltlkplfqg+e k +pnpfqldqldkifkvlghpt +kwptl++lphw+++ q+iq++ky+n+gly v l+ k++a+dllskmleydp+kr+ta+qaleheyf yelvgkigegtyglvylarskepahrgtkiaikkfkqskegdgvsptaireimllreirhenivklvnvhinradmslylafdyaeydlyeiirhhrekvelslnaytvksllwqllnglnylhsnwiihrdlkpsnilvmgedeehgivkiadfglarifqaplrplsdngvvvtiwyrapelllgakhytsavdlwavgcifaelltlkplfqgveaksspnpfqldqldkifkvlghptvdkwptlevlphwaenrqniqakkydntglysivhlppkseafdllskmleydplkritaeqaleheyf 621.0 2.9e-189 CMGC_CDK-CDK8 587 Cluster-3227.0-2F PF00069.22 31 339 1 264 YDVIGKIGEGTYGLVFLAKiKSNRSKPIAIKKFKQSKDGDGVSPTAIREIMLLREISHENVVKLANVHINhaDMSLYLAFDYAEHD-LYEIIRhhrdkVNQSINQYTVKSLLWQLLNGLNYLHSNWIIHRDLKPSNILVMGDGEeqgvVKIADFGLARIYQAPLKplsDNGVVVTIWYRAPELLlGAKHYTSAVDMWAVGCIFAELLTLKPLFQGQEVKGTpNPFQLDQLDKIFKVLGhPTQEKWPTLVNLphwqsdlqhiqgqkyenaglyhsvplstKNPAYDLLSKMLEYDPRKRLTAAQALEHEYF y ++ k+GeG++G V+ a+ +++++k +A+Kk+k++k+ + +++rEi +l++++h+n+v+l +v + + +lyl ++y+e++ l ++++ ++s+++ ++k++++q+l+gl+ylHs+ iiHrDlKp+NiL+ +ge +Ki+DFGla+ ++ k + +v+t +Y+APE+l ++++y+++vD+W++G+i++ellt kp+f+g++ k + + +ldql ki+k+lg +t+ek+p+ +l ++ a dll+k+l++dp+kRlta+++l+h+y+ yekleklGeGsfGkVykav.eketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee..kdelylvleyveggeladlls.....rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekge....lKitDFGlakelesssk...ltsfvgtreYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkek.vekeldqlekilkilg.etkeklpeasel............................seeakdllkkllkkdpkkRltaeellqhpyl 237.6 9.7e-73 Protein kinase domain 587 Cluster-3227.0-2F PF07714.14 35 238 5 202 GKIGEGTYGLVFLAKIK---SNRSKPIAIKKFKQSKDGDGvSPTAIREIMLLREISHENVVKLANVHInhADMSLYLAFDYAEH-DLYEIIRHHRDKvnQSINQYTVKSLLWQLLNGLNYLHSNWIIHRDLKPSNILVMGdgeeQGVVKIADFGLARIYQAPLKPLSDNGVVVTIWYRAPELLLGAKhYTSAVDMWAVGCIFAELLTL k+GeG++G V+ +++k ++++ +a+K++k++++ + + ++e+ ++++++h+n+vkl v + + +l++ ++y+e+ dL + +r++++k ++++ ++ s+ +q+ +G++yL+s+ ++Hrdl N+L+ + vvki+DfGLar + + ++++ + + + apE l k +ts+ D+W+ G + E++tl kklGeGafGeVvegtlkgekekkevkvavKtlkeeateee.keefleeakimkklkhpnivkllgvct..keepllivteyvegGdLlkfLrkkeek..ekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlse....nkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekk.ftsksDvWsfGvllwEiftl 114.4 3.6e-35 Protein tyrosine kinase 587 Cluster-3290.0-1R RLK-Pelle_RLCK-VI 458 723 1 267 ENMIGKGGSSQVYRGLLPDGKELAVKTLKPT-EDALKEFALEIEIITTLHHNNIISLFGFCFEDNHLLLVYDYLSRGSLEENLHGNRKVPLEFGWNERYKVAVGIAEALDYLHNRDSQPVIHRDIKSSNILLSDDFEPQLSDFGLAKWASPTSSHITCSDVVGTFGYLAPEYFMYGKVNYKIDVYAFGVVLLELLSGRKPISNDRPKGQESLVMWAKPILSSGKFVQLLDPSLGSNYDQEQVEKMVLAAALCIRRAPRARPHMTLVL en++GkGg+s+vy+g l+dgk++avk lk + e++ kef e+eii++l+h+n+++l+G+c+++++lllvy+yls+Gslee+Lhg++k + W+eRykvAvG+a+al+ylH++++++viHrD+k+sniLls+dfepqlsDFGlakw++ ++sh++++dv+GtFGylapeyfm+Gkvn k+dvyafgvvlLel++grkpi+++++kg+eslv+wakp+l+++k+ +l+dp+l +++d+e++e++vlaa+lcir+++++rp+++ vl enlvGkGgasevykgkledgklvavkrlkkseeekekeflaeleiisslshknvvkllGvcvdeeglllvyeylseGsleelLhgkkkkkelleWeeRykvAvGvakaleylHegcerrviHrDvkasniLlsedfepqlsDFGlakwlpekashllvkdveGtFGylapeyfmhGkvnektdvyafgvvlLelitgrkpidsksakgkeslvlwakplleekklkelvdpkleteadeeelerlvlaaslcirksakrrpslkevl 409.4 4.9e-125 RLK-Pelle_RLCK-VI 881 Cluster-3290.0-1R PF00069.22 458 669 4 209 ENMIGKGGSSQVYRGL-LPDGKELAVKTLKPTEDALK---EFALEIEIITTLHHNNIISLFGFCFEDNHLLLVYDYLSRGSLEENLHgnRKVPleFGWNERYKVAVGIAEALDYLHNRDsqpVIHRDIKSSNILLSDDFEPQLSDFGLAKWASPTSShitCSDVVGTFGYLAPEYFMYGKVNYKIDVYAFGVVLLELLSGRKPISNDRPKGQESLV ++ +G+G++++Vy+++ +gk+ AvK++k ++ k +++ Ei+i+ +l+h+ni+ l++++ e+++l+lv +y++ g+l++ l+ rk+ + +e k+a i+e+l+ylH++ +iHrD+K++NiL++++ e +++DFGlak ++ +s+ +++vgt YlAPE + ++ k+Dv++ Gv+l+ell+g+ p s+++ k + + leklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls..rkgs..lseeeakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekveke 153.4 4.9e-47 Protein kinase domain 881 Cluster-3290.0-1R PF07714.14 459 723 5 257 NMIGKGGSSQVYRGLLP-----DGKELAVKTLKPTED--ALKEFALEIEIITTLHHNNIISLFGFCFEDNHLLLVYDYLSRGSLEENLHGN-RKVplEFGWNERYKVAVGIAEALDYLHNRDsqpVIHRDIKSSNILLSDDFEPQLSDFGLAKWASPTSSHITCSDVVGTFGYLAPEYFMYGKVNYKIDVYAFGVVLLELLS-GRKPisndrpkgqeslvmwaKPILSSGKFVQLLDPSLGSNYDQEQVEKMVLAAALCIRRAPRARPHMTLVL + +G+G ++V++g l + + avKtlk + + + +ef e++i+++l+h+ni++l g+c ++++ll+v +y++ G+L++ L+ + +k ++ ++ +++a+ iA++++yL++++ ++Hrd+ + N+Lls++ ++sDfGLa+ + +++ + ++ + ++apE ++++k++ k Dv++fGv+l E+++ g++p p ls+ ++++ l+ + + ++ e++ C+++ p+ Rp+++ ++ kklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeeke..kltlkdllsfalqiAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep................ypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelv 134.0 3.6e-41 Protein tyrosine kinase 881 Cluster-3349.0-1R AGC_NDR 1 115 24 138 GNVYAMKKLKKAEMLRRGQVEHVKAERNLLAEVDSNYIVKLYFSFQDEDYLYLIMEYLPGGDMMTLLMRKDILTEDEARFYVAETVLAIESIHKHNYIHRDIKPDNLLLDRYGHL g+vyamkklkk+emlrrgqvehvkaernllaevds++ivkly+sfqde+ylylimeylpggd+mtllmrkd+ltedearfyvae+vlaiesihkhnyihrdikpdnllld++ghl gevyamkklkksemlrrgqvehvkaernllaevdselivklyysfqdeeylylimeylpggdlmtllmrkdtltedearfyvaesvlaiesihkhnyihrdikpdnllldkeghl 243.9 1.2e-74 AGC_NDR 115 Cluster-3349.0-1R PF00069.22 2 114 25 136 NVYAMKKLKKAEMLRRGQvEHVKAERNLLAEVDSNYIVKLYFSFQDEDYLYLIMEYLPGGDMMTLLMRKDILTEDEARFYVAETVLAIESIHKHNYIHRDIKPDNLLLDRYGH + +A+Kk+kk ++ + + ++v +E ++l+++++++iv+ly +f+++d+lyl++ey++gg++++ll rk +l+e+ea++++++++ ++e +H+++ iHrD+Kp+N+L+d+ g+ kivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekge 101.8 2.7e-31 Protein kinase domain 115 Cluster-3349.0-1R PF07714.14 5 111 32 139 AMKKLKKAEmlRRGQVEHVKAERNLLAEVDSNYIVKLYFSFQDEDYLYLIMEYLPGGDMMTLLMRK---DILTEDEARFYVAETVLAIESIHKHNYIHRDIKPDNLLLDR a+K+lk+ ++ + e++ e +++ +++ + ivkl+ +e+ l++++ey++gGd+ + L +k + lt ++ ++++ ++e +++++++Hrd+ N Ll++ avKtlkeea..teeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlse 46.9 1.4e-14 Protein tyrosine kinase 115 Cluster-3369.0-0R CK1_CK1 83 318 1 236 FHLGRKIGSGSFGEIYLGTNIQTNEQVAIKLENVKTKHPQLLYESKLYKLLQGGTGIPNVRWFGVEGDYNVLVMDLLGPSLEDLFNFCSRKLSLKTVLMLADQMINRVEFVHSKSFLHRDIKPDNFLMGLGRRANQVYVIDFGLAKKYKDSSTHQHIPYRENKNLTGTARYASMNTHLGIEQSRRDDLESLGYVLMYFLRGSLPWQGLRGGNKKQKYEKISAKKVSTSVEALCQGY f+lgrkigsgsfgeiylgtn+qtne+vaikle+vktkhpqllyeskly++lqggtgipn++wfgvegdynvlv+dllgpsledlfn+csrk+slktvlmladq+inrve+vhsk+flhrdikpdnflmglgr+anqvy+idfglakky+d++t++hipyrenknltgtaryas+nthlgieqsrrddleslgyvl+yflrgslpwqgl++g+kkqkyekis kkvsts+e+lc++y fklgrkigsgsfgeiylgtnvqtneevaiklesvktkhpqllyesklyrilqggtgipnlkwfgvegdynvlvldllgpsledlfnycsrkfslktvlmladqlinrveyvhskgflhrdikpdnflmglgrkanqvyiidfglakkyrdaktkkhipyrenknltgtaryasvnthlgieqsrrddleslgyvllyflrgslpwqglkagtkkqkyekisekkvstsievlcksy 477.6 4.6e-146 CK1_CK1 521 Cluster-3369.0-0R PF00069.22 83 300 1 211 FHLGRKIGSGSFGEIYLGTNIQTNEQVAIKLENVKTKHP----QLLYESKLYKLLQgGTGIPNVRWFGVEGDYNVLVMDLLGP-SLEDLFNfCSRKLSLKTVLMLADQMINRVEFVHSKSFLHRDIKPDNFLMGlgrRANQVYVIDFGLAKKYKDSSThqhipyreNKNLTGTARYASMNTHLGIEQSRRDDLESLGYVLMYFLRGSLPWQGLRGGN-KKQKYE ++ +k+G+GsfG++y +++ +t+++vA+K +++ + ++l E k+ k l+ i ++ + e d+ +lv++++ +l+dl + + +ls +++ +a q+++ +e++Hsk+++HrD+Kp+N+L+ + +++ ++DFGlak+++ ss+ ++ +gt +Y + + e s+ D+ slG +l+ +l g p++g +g + ++++++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklk.hpnivrlyevfeekdelylvleyveggeladlls.rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLid...ekgelKitDFGlakelesssk........ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeld 96.9 8.2e-30 Protein kinase domain 521 Cluster-3369.0-0R PF07714.14 84 343 2 256 HLGRKIGSGSFGEIYLGTNI----QTNEQVAIKLENVKTKHP---QLLYESKLYKLLqGGTGIPNVRWFGVEGDYNVLVMDLLG-PSLEDLFNFC--SRKLSLKTVLMLADQMINRVEFVHSKSFLHRDIKPDNFLMGLgrrANQVYVIDFGLAKKYKDSSTHqhipyRENKNLTGTARYASMNTHLGIEQSRRDDLESLGYVLMYFLR-GSLPWQGLrggNKKQKYEKISAKKVSTSVealcQGYPTEFASYFHYCRSLRFEDKPDYAYL +lg+k+G+G+fGe++ gt +++ +va+K + ++++ ++l e k+ k l i ++ + ++++ ++v++++ +L++ + ++kl+lk++l +a q+ + +e+ +sk+++Hrd+ N L+ ++v + DfGLa++ +++++ +++++ + ++ ++ + + + + D s G +l+ + g+ p++gl ++++ +ek++++k + + p+e+++ + C + + e+ p+++ l elgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkkl.khpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlse...nkvvkisDfGLardiekddey.....kkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypgl...sneevleklkegkrlekp....ekcpeelyelmkqCweedpeeRptfkel 58.0 5.6e-18 Protein tyrosine kinase 521 Cluster-3406.0-1F AGC_RSK-2 36 183 1 148 RMLKRLGGGDIGTVHLAELIGTRTYFAMKVMDKEALASRKKLPRAQTEREILQSLDHPFLPTLYSHFETEKFSFLVMEYCPGGDLHALRQKQPGKFFPEHAARFYVAEVLLALEYLHMLGIIYRDLKPENILVREDGHIMLSDFDLSL ++lk+lG Gdig+v+l+el gt+++fa+kv+dkeala+rkkl ra++ereil++ldhPflptly++fetekf+ lv+e+cpggdLh+lr++qp k f e+a+rfy+aev+laleylh+lgi+yrdLkPen+lvredGhiml+DfDLsl kllkklGsGdigsvylvelrgtealfalkvldkealakrkklkraeaereilelldhPflptlyasfetekfvclvvefcpggdLhvlrerqpkkvfseeavrfyaaevvlaleylhalgivyrdLkPenvlvredGhimltDfDLsl 250.3 1.6e-76 AGC_RSK-2 183 Cluster-3406.0-1F PF00069.22 36 182 2 145 RMLKRLGGGDIGTVHLAELIGTRTYFAMKVMDKEALASRKKlPRAQTEREILQSLDHPFLPTLYSHFETEKFSFLVMEYCPGGDLHALRQkqPGKFFPEHAARFYVAEVLLALEYLHMLGIIYRDLKPENILVREDGHIMLSDFDLS + l++lG G+ G+V a t+ +A+K+++ke ++k+ ++++E +il++l+hp++ +ly+ fe+++ +lv+ey++gg+l+ l + + ++e+ a+++++++l +leylH gii+rDlKpeNiL+ e+g+++++DF+l+ ekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls..rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGla 130.9 3.4e-40 Protein kinase domain 183 Cluster-3406.0-1F PF07714.14 37 182 3 151 MLKRLGGGDIGTVHLAELI----GTRTYFAMKVMDKEALASRkkLPRAQTEREILQSLDHPFLPTLYSHFETEKFSFLVMEYCPGGDLHA-LRQKQPGKFFPEHAARFYVAEVLLALEYLHMLGIIYRDLKPENILVREDGHIMLSDFDLS + k+lG G G+V+ ++l +++ a+K++++ea +++ + +e +i+++l+hp + l+ e+ ++v+ey++gGdL+ Lr+k+ + + + +++++ ++eyL+ ++ rdl N+L++e+ ++ +sDf L+ lgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateee..keefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLa 69.9 1.4e-21 Protein tyrosine kinase 183 Cluster-3406.1-1R AGC_RSK-2 78 181 151 254 TNARSMSFVGTHEYLAPEIIKGEGHGSAVDWWTFGIFLYELLFGRTPFKGAGNRATLFNVVGQPLRFPETPTVSFAARDLIRGLLVKEPQHRLAYRRGATEIKQ +++rs+sfvGt+eylaPeiikgeghgsavdWW++Gi+lyell+g+tPfkg+ +++tl+nv+ ++l+fpe+++vs++ardlir+ll+k+p++rl+++rga+eik+ sakrsnsfvGteeylaPeiikgeghgsavdWWalGillyellygktPfkgknreetlanvlkkelefpeeaavsleardlirkllekdpkkrlgskrgaaeikk 166.6 5.6e-51 AGC_RSK-2 181 Cluster-3406.1-1R PF00069.22 82 172 154 255 SMSFVGTHEYLAPEIIKGEGHGSAVDWWTFGIFLYELLFGRTPFKGAGNRATLFNVVGQ-----------PLRFPETPTVSFAARDLIRGLLVKEPQHRLAY +sfvgt+eYlAPE++k+++++++vD+W+ G+ lyell+g++pf+g ++ + + + q + +pe ++s a+dl++ ll k+p++Rl ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRlta 69.8 1.5e-21 Protein kinase domain 181 Cluster-3406.1-1R PF07714.14 88 172 169 253 THEYLAPEIIKGEGHGSAVDWWTFGIFLYELLF-GRTPFKGAgNRATLFNVVGQPLRFPETPTVSFAARDLIRGLLVKEPQHRLAY +++apE++k + s+ D W fG+ l+E++ g++p++g + +++++ + + r ++ +++ + +l++ + ++p++R + pvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypgl.sneevleklkegkrlekpekcpeelyelmkqCweedpeeRptf 31.2 8.6e-10 Protein tyrosine kinase 181 Cluster-3480.0-0F AGC-Pl 1 125 125 249 LKPENILLDAEGHAMLTDFGLAKEFDENTRSNSLCGTVEYMAPEIIQCGGHDKAADWWSVGILLYEMLTGKPPFISGNRHKIQQKILKDRMKLPGFLSSDAHSLLKGLLQKEAKKRLGSGPRGSE lkpenillda+gh+mltdfglake++e++rsnslcgtveymapei++ ghdkaadwwsvgillyemltgkppf++ n++k+qqki+kd++klp flssda+sllkgllqk+++krlgsgp gse lkpenilldadghvmltdfglakevkedsrsnslcgtveymapeivkakghdkaadwwsvgillyemltgkppfvaknkqklqqkivkdkiklpkflssdaksllkgllqkdpekrlgsgpsgse 230.1 2.3e-70 AGC-Pl 125 Cluster-3480.0-0F PF00069.22 1 118 124 254 LKPENILLDAEGHAMLTDFGLAKEFDENTRSNSLCGTVEYMAPEIIQCGGHDKAADWWSVGILLYEMLTGKPPFISGNRH-----KIQQ-----KIL---KDRMKLPGFLSSDAHSLLKGLLQKEAKKRLG lKpeNiL+d +g+ ++tDFGlake++++++ +s +gt eY+APE+++ +++k++D+Ws+G++lye+ltgkppf + +++ +++q kil k ++ + ls++a +llk ll+k+ kkRl+ lKpeNiLidekgelKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRlt 117.6 4.1e-36 Protein kinase domain 125 Cluster-3480.0-0F PF07714.14 4 116 133 250 ENILLDAEGHAMLTDFGLAKEF---DENTRSNSLCGTVEYMAPEIIQCGGHDKAADWWSVGILLYEMLT-GKPPFISGNRHKIQQKILK-DRMKLPGFLSSDAHSLLKGLLQKEAKKR N+Ll+ + ++ ++DfGLa++ de +++++ v++mapE+++ + +++D Ws G+ll+E++t g+ p+ + + +++ +k+ + r++ p +++ ++l+k +++++++R rNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeR 61.8 4e-19 Protein tyrosine kinase 125 Cluster-350.0-2R CAMK_CAMKL-CHK1 2 101 1 100 YELGRTIGEGTFAKVKFAQNTENGRNVAIKVIAKSTILRHKMVDQIKREISIMKIVRHPCIVRLHEVLSSHAKIYIVLELVKGGQLFDKIVNQGRLSENE yelGr++Gegtfakvk+a+++e+g++vaikv+ k+++l++k+v+qikreis++k+vrhp +vrl+evl++++kiy+vle+vkGG+lf+ki+++grl+e+e yelGrllGegtfakvklardletgesvaikvldkekvlkaklveqikreisvlklvrhpnvvrllevlatkskiylvleyvkGGelfekiakkgrlkede 142.2 1.5e-43 CAMK_CAMKL-CHK1 102 Cluster-350.0-2R PF00069.22 2 101 1 99 YELGRTIGEGTFAKVKFAQNTENGRNVAIKVIAKSTILRHKMvDQIKREISIMKIVRHPCIVRLHEVLSSHAKIYIVLELVKGGQLFDKIVNQGRLSENE ye +++GeG+f+kV a ++e+g+ vA+K+i k+ + k +++ rEi+i+k ++hp ivrl ev++++ ++y+vle+v+gg+l+d + ++g lse+e yekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseee 78.3 3.8e-24 Protein kinase domain 102 Cluster-350.0-2R PF07714.14 3 94 2 95 ELGRTIGEGTFAKVKFAQNT----ENGRNVAIKVIAKSTilRHKMVDQIKREISIMKIVRHPCIVRLHEVLSSHAKIYIVLELVKGGQLFDKIVNQ elg+++GeG+f++V ++ + ++ +va+K++ +++ +++ +++ +e++imk ++hp iv+l+ v +++ +++iv+e+v+gG+L + + ++ elgkklGeGafGeVvegtlkgekekkevkvavKtlkeea..teeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk 53.9 1e-16 Protein tyrosine kinase 102 Cluster-3546.0-0R CAMK_CDPK 97 357 1 259 YTIGKLLGHGQFGYTYVAIDKSNGDRVAVKKIEKNKMVLPIAVEDVKREVKILKALAGHENVVQFHNSFEDDSYVYIVMELCEGGELLDRILSKkdSRYTEKDAAIIVRQMLKVAAECHLHGLVHRDMKPENFLFKSPKEDSSLKATDFGLSDFIRPGKKFQDIVGSAYYVAPEVLKRKSGPESDVWSIGVITYILLCGRRPFWDKTEDGIFKEVLRNKPDFRRKPWPSISNGAKDFVKKLLVKDPRARLTAAQALSHPWV y++gk lG+G+fG++++a +k++g++vAvK i+k+k++ +vedv+revkilk+l+gh+nvvq+++ +ed++ v++vmelceggelldril++ ++y+e++aa +vrq+l+v a+cH +g+vhrD+KPeNfl++s +ed++lka+DFGls+f+++g++++divGs+yyvaPEvlkr+ g+e+dvWs+Gvi+yillcg++pfw++te++ifk+vl++++df+++pw+s+s+ akd+v++lL kdp+ Rlta+q+L+hpW+ yelgkelGrGefGvvrlatekatgeevAvKsiskrklskaedvedvrrevkilkhlsghknvvqlkgayedkdsvhlvmelceggelldrilar..gkyseraaakvvrqilevvaacHskgvvhrDlKPeNflltskeedaplkaiDFGlsvfvkegerledivGspyyvaPEvlkrsygkeadvWsaGvilyillcgvppfwaeteeeifkavlkaeldfksepwksvseeakdlvrrlLekdpkkRltaeqvLehpWl 381.9 1.2e-116 CAMK_CDPK 576 Cluster-3546.0-0R PF00069.22 97 357 1 264 YTIGKLLGHGQFGYTYVAIDKSNGDRVAVKKIEKNKMVLPIAvEDVKREVKILKALAgHENVVQFHNSFEDDSYVYIVMELCEGGElLDRILSKKDSrYTEKDAAIIVRQMLKVAAECHLHGLVHRDMKPENFLFKSPKEdssLKATDFGLSDFIRPGKKFQDIVGSAYYVAPEVL-KRKSGPESDVWSIGVITYILLCGRRPFWDKTEDGIFKEVLRN---------KPDFRRKPWPSISNGAKDFVKKLLVKDPRARLTAAQALSHPWV y+ + lG G+fG y a++k++g+ vAvKki+k+k+ ++v rE+kilk l h+n+v++ ++fe+++++y+v+e++egge l+++ls+k s ++e++a i++q+l+ + +H +g++HrD+KpeN+L+++ +e lK tDFGl+ ++ ++k++++vg+ +Y+APEvl +++ ++++DvWs+Gvi y ll+g+ pf++++++ +++ l++ + ++ + + ++s+ akd++kkll kdp+ Rlta+++l+hp++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklk.hpnivrlyevfeekdelylvleyvegge.ladllsrkgs.lseeeakkiakqilegleylHskgiiHrDlKpeNiLidekge...lKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 232.2 4.4e-71 Protein kinase domain 576 Cluster-3546.0-0R PF07714.14 99 349 3 254 IGKLLGHGQFGYTYVAIDK----SNGDRVAVKKIEKNKMVlpIAVEDVKREVKILKALaGHENVVQFHNSFEDDSYVYIVMELCEGGELLDRILSK-KDSRYTEKDAAIIVRQMLKVAAECHLHGLVHRDMKPENFLFKSpkeDSSLKATDFGLSDFI---RPGKKFQDIVGSAYYVAPEVLKRK-SGPESDVWSIGVITYILLC-GRRPFWDKTEDGIFKEVlRNKPdfRRKPWPSISNGAKDFVKKLLVKDPRARLTAA +gk lG+G+fG + ++ k ++ +vavK+++++++ + e++ +e+ki+k+l h+n+v+++ +++ ++iv+e++egG+Ll+ + +k ++++ t kd +++q+ k + + + lvHrd+ N L ++ ++ k +DfGL++ i kk ++ + ++apE+lk+k +sDvWs Gv+++ +++ g++p+++ ++ +++ + +++ r + ++++ ++++k+ + +dp+ R t + lgkklGeGafGeVvegtlkgekekkevkvavKtlkeeate..eekeefleeakimkkl.khpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlse...nkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevlekl.kegk..rlekpekcpeelyelmkqCweedpeeRptfk 103.0 1e-31 Protein tyrosine kinase 576 Cluster-3577.0-0F CMGC_GSKL 1 170 91 258 LYSSVGPSGAEQTLEYAPPEAFLNASWYRAPSSVTIKYDMWSVGVVILELILGSPNVFQINAKTRALLDLHLEGWSESLKELAYKLRAFMEICILIPGSSSKLHQNWGPNGHDsiSPVPWKCSEEFFAYHIKSRDPLKIGFPSVHALRLVRDLLCWKPEDRLTVDEALQH ly s GPs aeqtleyaPPea ln sW + ++s + kyD+wsvGvv+LElilg+p+vfqi+a+traLl+ +l+G++e+ k+++++lra++e+cil+p+++sk +++ p++ + + wkc+ee+++ iksrdpl+iG++ v alrl++ ll w+p+dR +v+ealqh lygseGPsraeqtleyaPPeallnrsWegfrasrklkyDiwsvGvvvLElilgtpqvfqisartraLleqrlrGrdeqekkqlfllrallelcilvpqapskhppassplrGr..llaswkcteealleliksrdplgiGledvvalrllvkllqwdpadRksveealqh 230.3 2e-70 CMGC_GSKL 170 Cluster-3577.0-0F PF00069.22 12 170 159 261 QTLEYAPPEAFlnaswyrAPSSVTIKYDMWSVGVVILELILGSPNVFQINAKTRALLDLHL-EGWSESLKELAYKLRAFMEIcilipgsssklhqnwgpnghdsispvpwkcseeffayhiksrdplkigfpSVHALRLVRDLLCWKPEDRLTVDEALQH t eY +PE ++++ k D+Ws+Gv+++el+ g p + + k+++ +l+ e + l+e kl+ e+ s +a++l+++ll+++p++Rlt++e+lqh gtreYlAPEvl.......keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeasel..................................................seeakdllkkllkkdpkkRltaeellqh 42.3 3.8e-13 Protein kinase domain 170 Cluster-3768.1-0R RLK-Pelle_DLSV 2 172 81 254 QYLFDNNKDRILSWKERYNIIVGTAEGIAFLHGGSEYRIVHRDIKTSNVILDENFEPKIADFGLARSFALDRSHLST-GIAGTLGYMAPEYLVKGQLTEKADVYSYGVLVLEIVCNRKSNAF--ADDSGSLLQSVWKQYKSDRLTESVDPLLKGNFPEFEASRALRIGLLCTQA ++lfd++k++ l+Wk+r++ii g+a+G+++Lh s+ +i+hrD+K+sN++Ld++++pkiaDFGlar f d+++ st ++gtlgYmaPey+++gql+ek+Dvys+Gvlvleiv +k++ + +++ +ll+ +wk++++++l+e vd+ lk ++ + e+ r ++i+llc+q+ kflfdeekkkeldWktrfkiikgiarGllYLheesrlkiihrDlKasNiLLdkemnpkiaDFGlarlfeedqteastkrvvgtlgYmaPeyalegqlseksDvysfGvlvleivsGkknsslkeeeeaeelleeawklweeekllelvdkslkeeaekeevlrcieiallcvqe 208.5 8.5e-64 RLK-Pelle_DLSV 173 Cluster-3768.1-0R PF00069.22 11 119 93 196 RILSWKERYNIIVGTAEGIAFLHggsEYRIVHRDIKTSNVILDENFEPKIADFGLARSFALDRShlSTGIAGTLGYMAPEYLVKGQLTEKADVYSYGVLVLEIVCNRKS +ls +e +i+ ++eg+++lH + +i+HrD+K++N+++de+ e Ki+DFGla+ + + + t + gt Y+APE l + + ++k+Dv+s+Gv+++e+++++ gslseeeakkiakqilegleylH...skgiiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkpp 92.5 1.8e-28 Protein kinase domain 173 Cluster-3768.1-0R PF07714.14 2 138 90 224 QYLFDNNKDRILSWKERYNIIVGTAEGIAFLHggsEYRIVHRDIKTSNVILDENFEPKIADFGLARSF-ALDRSHLSTGIAGTLGYMAPEYLVKGQLTEKADVYSYGVLVLEIVCNRKSNAFADDSGSLLQSVWKQYK ++L ++++++ l+ k+ +++++ A+G+++L+ + ++vHrd+ + Nv+l+en ki+DfGLar+ d+ + +++ + +mapE l ++++t+k+Dv+s+Gvl+ Ei+++ ++ ++ ++l+ + ++++ kfLrkkeekekltlkdllsfalqiAkGmeyLe...skklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevleklkegkr 87.9 4.4e-27 Protein tyrosine kinase 173 Cluster-3770.0-1F RLK-Pelle_LRR-XI-1 25 292 2 265 NIVGKGCSGIVYRVETPGQQVIAVKRLwPKKTDEIPQKDHFSAEIRVLGSIRHKNIVRLLGCCDNGKTRLLLFDYISNGSLAGLLHEQKI-FLNWDARYKVLLGAAKGLAYLHHDCIPSIIHRDIKSNNILVDPNFEAFLADFGLARHTNSCDPSSASNKVAGSLGYIAPECGYSLKITEKSDVYSYGIVLLEILTGMEPTDPRIPDGVHIVMWVNQElriKHRESTSVVDPQLlRGSSTQTEEMIQVLGVALLCVNPSPDERPTMKDI n++G+G+sG VY++e++ ++v+aVK+l +++++ ++++f+ae+++lg+irh+niv+llg+c + +++ll+++y++ngsL+ llh++k l+W+aR+k+ +g+A+gLaYlhhdc p i+HrD+ks+niL d +fea +adfgla+ ++ + s+ + vags+GYiaPe++y+lk+teksDvYS+G+vlLe++tg +p+d+++ ++v+iv wv+++ k+++ ++++D++l + s++++eem++vl vallc++ sp+eRPtm+++ nviGrGgsGkVYkaelksgevvaVKkl.eaakskekseksfeaevktlgkirhrnivkllgfcsseeakllvyeymengsLgellhgkkkkeldWeaRlkiavgvAegLaYlhhdcsppivHrDvkssniLLdsefeakvadfglakvldekkeseslsavagsyGYiaPeyaytlkvteksDvYSfGvvlLelvtgkkpvdeefgesvdivkwvaek...kkekveeilDekl.avseaaeeemlkvlkvallctsespeeRPtmrev 340.4 4.9e-104 RLK-Pelle_LRR-XI-1 414 Cluster-3770.0-1F PF00069.22 24 293 4 259 SNIVGKGCSGIVYRVE-TPGQQVIAVKRLWPKKTDEIPQkDHFSAEIRVLGSIRHKNIVRLLGCCDNGKTRLLLFDYISNGSLAGLLHEQKIFLNWDARyKVLLGAAKGLAYLHHDCipsIIHRDIKSNNILVDPNFEAFLADFGLARHTNSCDPssaSNKVAGSLGYIAPECGYSLKITEKSDVYSYGIVLLEILTGMEPTDPRIPDG--VHIVMWVNQELRIKHRESTS------VvdpqllrgsstqTEEMIQVLGVallCVNPSPDERPTMKDIT + +G+G +G Vy++ + ++ +AvK++ +k+++ + +++ +Ei++l +++h+nivrl++++ + ++++l+++y+++g+la ll++++++ +++a+ k++ ++gl+ylH+ + iiHrD+K++NiL+d + e ++DFGla++ +s+ + +++ g+ Y+APE + ++++k+Dv+s+G++l+e+ltg +p + + ++++ + + l+i + ++ + + ee++++l +++ p +R+t++++ leklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeak.kiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeasel............seeakdllkk...llkkdpkkRltaeell 155.6 9.9e-48 Protein kinase domain 414 Cluster-3770.0-1F PF07714.14 25 295 5 259 NIVGKGCSGIVYRVETP-----GQQVIAVKRLwpKKTDEIPQKDHFSAEIRVLGSIRHKNIVRLLGCCDNGKTRLLLFDYISNGSLAGLLHEQ--KIFLNWDARYKVLLGAAKGLAYLHHDCipsIIHRDIKSNNILVDPNFEAFLADFGLARHTNSCDPSSASNKVAGSLGYIAPECGYSLKITEKSDVYSYGIVLLEILT-GMEPtdpripdgvhivmwvnqelrIKHR----ESTSVVDPQLLRGSSTQTEEMIQVlgvALLCVNPSPDERPTMKDITAM + +G+G G V++ + ++ +avK l k++ + +k++f e++++ +++h+niv+llg+c ++++ l++++y+++G+L L+++ k l+ + +++ l AkG++yL++ ++Hrd+ + N+L++ n + ++DfGLar++++ d +++++ ++ ++apE+ + k+t+ksDv+s+G++l Ei+t g ep +++ + + + + l+ ++ +ee+ ++ C++ +p+eRpt+k+++ kklGeGafGeVvegtlkgekekkevkvavKtl..keeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep....................ypglsneevleklkegkrlekpekcpeelyel...mkqCweedpeeRptfkelvek 145.0 1.6e-44 Protein tyrosine kinase 414 Cluster-3810.0-0R CMGC_MAPK 29 118 16 105 RSGLNSETNGYVAIKKIANDFHNKTDAKRSLREIKFLRHMDHENVVALKDIISPPQRESFNDVYIAYELMDTDLHQIIRSNQALSEEHWQ s +++et+ vaikki++ f+n++dakr lreik+lr+++hen+v+lkd+++p+++e+f+Dvyi++elmdtdlhq+i+sn++l+eeh q csavdtetgekvaikkiedvfenlidakrvlreikllrrlehenivelkdvlkpaekeefkDvyivlelmdtdlhqviksndelteehvq 118.3 2.8e-36 CMGC_MAPK 210 Cluster-3810.0-0R PF00069.22 30 117 17 100 SGLNSETNGYVAIKKIANDFHNKTDAKRSLREIKFLRHMDHENVVALKDIISPpqresFNDVYIAYELMDTD-LHQIIRSNQALSEEHW +++++et+ vA+Kki ++ +k++ k+ lrEik+l++++h+n+v l+++++ +++y+ e+++++ l+++++ +++lsee+ kaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee.....kdelylvleyveggeladllsrkgslseeea 45.7 3.4e-14 Protein kinase domain 210 Cluster-3810.0-0R PF07714.14 33 117 24 96 NSETNGYVAIKKIANDfHNKTDAKRSLREIKFLRHMDHENVVALKDIISppQRESfndVYIAYELMDT-DLHQIIRSNqalseehW +++++ va+K++ ++ +++++ ++ l+e+k++++++h+n+v+l +++ ++e+ ++i e+++ dL++ +r++ kekkevkvavKtlkee.ateeekeefleeakimkklkhpnivkllgvct..keep...llivteyvegGdLlkfLrkk.......e 27.8 9.4e-09 Protein tyrosine kinase 210 Cluster-3868.0-1R RLK-Pelle_RLCK-VIIa-2 75 250 2 180 ILGEGGFGTVYKGYIDENVRVGLKS---LPVAVKVLNKEGLQGHREWLTEVNFLGQLRHSNLVKLIGYCCEDDHRLLVYEFMFRGSLENHLFRKATIPLSWSTRMMIALGAAKGLAFLHNAERPVIYRDFKTSNILLDSDYTAKLSDFGLAKAGPQGDETHVSTRVMGTYGYAAPEYVM +lGeGgfG+vykg+ide+++ +lk+ l+vavk lnkeglqgh+ewl+ev+fLgql+h nlvkliGyc+edd+rllvyE+m +gslenhlfr+++ +lsW+tr+ ialgaAkglafLh+ae++viyRdfk+sniLld+d++aklsdfglak+gp++d+thvstrvmgtygYaaPeyv+ llGeGgfGsvykgvidektkaelkageglavavkklnkeglqghkewlaevefLgqlshpnlvkliGycledderllvyEymakgslenhlfrrssealsWetrlkialgaAkglafLheaekkviyRdfkasniLldedfnaklsdfglakegpeedkthvstrvmgtygYaaPeyva 313.8 6.8e-96 RLK-Pelle_RLCK-VIIa-2 250 Cluster-3868.0-1R PF00069.22 73 249 4 169 DYILGEGGFGTVYKGYI-DENVRVGLKSLPVAVKVLNKEglqghREWLTEVNFLGQLRHSNLVKLIGYCCEDDHRLLVYEFMFRGSLENHLFRKATipLSWSTRMMIALGAAKGLAFLHNAErpVIYRDFKTSNILLDSDYTAKLSDFGLAKAGPQGDEthvSTRVMGTYGYAAPEYV + lGeG+fG+Vyk++ +++ v +K + + + +ke ++ l+E+++l +l+h+n+v+l++++ e+d+++lv e++ g+l+++l rk + ls ++ ia ++gl++lH+++ +i+rD K++NiL+d++ K++DFGlak ++ + t ++gt Y APE + leklGeGsfGkVykaveketgkivAvKkikkekakkkke.....kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgs..lseeeakkiakqilegleylHskg..iiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvl 120.1 7.1e-37 Protein kinase domain 250 Cluster-3868.0-1R PF07714.14 75 249 6 178 ILGEGGFGTVYKGYIDEnvRVGLKSLPVAVKVLNKEGLQG-HREWLTEVNFLGQLRHSNLVKLIGYCCEDDHRLLVYEFMFRGSLENHLFRK-ATIPLSWSTRMMIALGAAKGLAFLHNAErpVIYRDFKTSNILLDSDYTAKLSDFGLAKAGPQGDETHVSTRVMGTYGYAAPEYV lGeG fG+V++g++++ + k++ vavK+l++e + ++e l+e++++ +l+h n+vkl+g c ++++ l+v e++ G+L+++L +k ++ +l+ ++ + +al AkG+++L++ + ++ rd + N+Ll+++ ++k+sDfGLa++ + de++++++ + + apE + klGeGafGeVvegtlkg..ekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskk..lvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEsl 117.8 3.2e-36 Protein tyrosine kinase 250 Cluster-3871.0-1F RLK-Pelle_LRR-Xa 67 180 3 115 TMYKAVLEDGTCLMVKRLQYAQQSEKEFTSEMTTLGNVKHGNLVPLLGFCTTKKERLLVYKHMPNGTLHDKLHVVNEGEkPLDWPLRLKIGIKAAKGFAWMHHSCNPRIIHRNI t+ykavledg+ l+vkrlq +++sek+f++em +lg+++h nlvPllG+c ++erllvykhm+nG+l+d+l+ +e e +ldW+ rl+i++ aa+G+aw+hhscnpri+hrni tvykavledgsvlavkrlqssklsekqfraemeklgelrhrnlvPllGycvveeerllvykhmsnGslydqlkeaeeke.eldWktrlriavGaarGlawlhhscnprilhrni 175.9 6.5e-54 RLK-Pelle_LRR-Xa 180 Cluster-3871.0-1F PF07714.14 56 180 3 130 KENIIGSGRTGTMYKAVLE-----DGTCLMVKRL--QYAQQSEKEFTSEMTTLGNVKHGNLVPLLGFCTTKKERLLVYKHMPNGTLHDKLHVVnEGEKPLDWPLRLKIGIKAAKGFAWMHHScnpRIIHRNI ++ +G+G+ G+ +++ l+ + + +vK l ++ +++++ef++e++++ ++kh n+v llg+ct +++ l+v +++++G+L++ L+ e +++l+ l++ ++ AkG +++++ +++Hr++ lgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk.eekekltlkdllsfalqiAkGmeyLesk...klvHrdl 60.2 1.2e-18 Protein tyrosine kinase 180 Cluster-3871.0-1F PF00069.22 55 180 2 124 SKENIIGSGRTGTMYKAV-LEDGTCLMVKRLQYAQQSEKE---FTSEMTTLGNVKHGNLVPLLGFCTTKKERLLVYKHMPNGTLHDKLHvvneGEKPLDWPLRLKIGIKAAKGFAWMHHSCnprIIHRNI +k++ +G+G +G+ ykav e+g vK+++ ++++k+ +++E++ l ++kh n+v l++++++k+e++lv ++++g+l+d l+ ++ l+ ki + ++g++++H+ + iiHr + ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls....rkgslseeeakkiakqilegleylHskg...iiHrDl 51.4 6e-16 Protein kinase domain 180 Cluster-399.0-1F RLK-Pelle_LRK10L-2 1 80 35 112 NGEEFINEVASISRTSHVNIVSLLGFCFEGSKRALIYEFMPNGSLEKFIYSNSSlaKCQLGWEKLFQIAVGIARGIEYLH ngeefinevasi+r+shvnivsllGfc egskral+ye++pngsl+k+i+s++s k +l +ekl++ia+giarG+eylh ngeefinevasigrishvnivsllGfclegskralvyeylpngsldkyifsees..keslsleklleialgiarGleylh 129.6 1.1e-39 RLK-Pelle_LRK10L-2 80 Cluster-399.0-1F PF07714.14 3 80 46 121 EEFINEVASISRTSHVNIVSLLGFCFEGSKRALIYEFMPNGSLEKFIYSNSSlaKCQLGWEKLFQIAVGIARGIEYLH eef++e++ +++++h niv+llg+c ++++ ++ e++++G+L+kf+ ++++ k +l ++l+++a+ iA+G+eyL+ eefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkee..kekltlkdllsfalqiAkGmeyLe 55.0 4.8e-17 Protein tyrosine kinase 80 Cluster-399.0-1F PF00069.22 3 80 43 115 EEFINEVASISRTSHVNIVSLLGFCFEGSKRALIYEFMPNGSLEKFIYSNSSLAKCqlgweKLFQIAVGIARGIEYLH +++++E++ + +++h niv l++++ e +++ l+ e++++g+l++++ ++sl+++ ++ +ia i++g+eylH kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslsee.....eakkiakqilegleylH 39.3 3.2e-12 Protein kinase domain 80 Cluster-4023.1-2R CAMK_OST1L 109 199 1 92 YDLVRDIGSGNFGVARLLRDKQTKELVAVKYIERG-DKIDENVQREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGR y++v+d+gsg+fGvarl+rdk+tkelvAvK+ierg +k+denv+rEi+nhrsLrHpnivrfkev+ltpthla+vmEYa+ggel+e+++++gr yevvkdlgsgsfGvarlvrdketkelvAvKlierglekvdenvkrEilnhrsLrHpnivrfkevvltpthlalvmEYadggelleyvskkgr 124.6 3.2e-38 CAMK_OST1L 199 Cluster-4023.1-2R PF00069.22 109 194 1 89 YDLVRDIGSGNFGVARLLRDKQTKELVAVKYIERGDKID---ENVQREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERI y ++ +G+G+fG+ ++k+t++ vAvK i++ ++ + ++v+rEi +++l+hpnivr++ev+ ++++l +v+ey++ggel++++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladll 66.9 1.1e-20 Protein kinase domain 199 Cluster-4023.1-2R PF07714.14 111 193 3 91 LVRDIGSGNFGV---ARLL-RDKQTKELVAVKYIERGDKID--ENVQREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFER l +++G+G+fG ++l ++++++ vavK ++++ + + e++ +e+ ++l+hpniv++ v++ +l iv+ey++gG+L + lgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkf 39.1 3.3e-12 Protein tyrosine kinase 199 Cluster-4057.0-0F TKL-Pl-3 1 144 135 278 LADFGLAEYKTDLKKVSTENWKSSGKPTGGFHKEHMVGTLIYMAPEILRKEMHTEKSDVYSFGISLNELLTGVVPYTDLRAEAQAHTVLEMNYTEQQLTAAVVSEGQRPILAGPESGASTSLLSLIQRCWDPIPENRPSFDDII ladfGla++k dlkkv+ en++ssGkptGGfhk +mvGtliymapeilrk+++teksdvysf+i++nelltGvvpytd +aeaqahtvlemnyteqql+aavvseG rp+la++es+a +sl+sli++cw+ p++rpsfd+i+ ladfGlavkkkdlkkvdvenirssGkptGGfhkknmvGtliymapeilrkdvkteksdvysfailinelltGvvpytdrkaeaqahtvlemnyteqqlaaavvseGlrpllaeiessapkslsslieacwesdpakrpsfdqil 250.3 1.8e-76 TKL-Pl-3 164 Cluster-4057.0-0F PF00069.22 1 144 139 259 LADFGLAEYKTDLKKvstenwkssgkptggfhKEHMVGTLIYMAPEILRKEMHTEKSDVYSFGISLNELLTGVVPYTDLRAEA-QAHTVLEMNYTEQQLTA-AVVSE----GqrpilagpesgaSTSLLSLIQRCWDPIPENRPSFDDII ++DFGla+ + +k ++++vgt Y+APE+l+++++++k+Dv+s G+ l elltg p+ + + + +++ + ++ + + l+ + ++ s ++++l++++++ p++R+++++++ itDFGlakelesssk.................ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeasel............seeakdllkkllkkdpkkRltaeell 66.9 1.1e-20 Protein kinase domain 164 Cluster-4057.0-0F PF07714.14 33 147 163 260 KEHMVGTLIYMAPEILRKEMHTEKSDVYSFGISLNELLT-GVVPYTDLRAEAqahtvlemnyteqqlTAAVVSEGQRpiLAGPEsGASTSLLSLIQRCWDPIPENRPSFDDIIVEL ke+ + +mapE+l+++ t+ksDv+sfG+ l E++t g py++l++e +++ ++eg+r l+ pe ++++l +l+++Cw+ pe+Rp+f++++ +l keeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsnee...............vleklkegkr..lekpe.kcpeelyelmkqCweedpeeRptfkelvekl 58.5 4e-18 Protein tyrosine kinase 164 Cluster-412.0-1R CAMK_CAMKL-CHK1 19 126 1 108 YELGRILGEGNFGKVKYAKNLDSGRSVAIKILEKNRIFDLKITEQIEREIGTLRLLKHPNVVRLHEVLASKTKIYMVLEYVNGGALFDRIANGGRLSEAKGRKLFHQL yelGr+lGeg+f+kvk+a++l++g+svaik+l+k+++++ k++eqi+rei +l+l++hpnvvrl+evla+k+kiy+vleyv+GG lf++ia+ grl+e ++rk+f+ql yelGrllGegtfakvklardletgesvaikvldkekvlkaklveqikreisvlklvrhpnvvrllevlatkskiylvleyvkGGelfekiakkgrlkedearkyfqql 148.5 1.7e-45 CAMK_CAMKL-CHK1 126 Cluster-412.0-1R PF00069.22 19 126 1 107 YELGRILGEGNFGKVKYAKNLDSGRSVAIKILEKNRIFDLKItEQIEREIGTLRLLKHPNVVRLHEVLASKTKIYMVLEYVNGGALFDRIANGGRLSEAKGRKLFHQL ye + lGeG+fGkV a++ ++g+ vA+K+++k+++ + k +++ rEi l+ lkhpn+vrl ev+ +k+++y+vleyv+gg l+d++ + g lse++ +k+++q+ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqi 87.3 6.8e-27 Protein kinase domain 126 Cluster-412.0-1R PF07714.14 20 109 2 93 ELGRILGEGNFGKVKYAKNL----DSGRSVAIKILEKNRifDLKITEQIEREIGTLRLLKHPNVVRLHEVLASKTKIYMVLEYVNGGALFDRIA elg+ lGeG+fG+V ++ ++ +va+K+l+++ + + +e++ +e+ +++ lkhpn+v+l+ v ++ ++++v+eyv+gG L + + elgkklGeGafGeVvegtlkgekekkevkvavKtlkeea..teeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLr 53.3 1.5e-16 Protein tyrosine kinase 126 Cluster-4121.0-0F CAMK_CAMKL-CHK1 229 484 1 256 YELGRTLGEGSFAKVKFARNVETGENVAIKILDKEKVLRHKMIGQIKREISTMKLIRHPNVIRMYEVMASKLKIYIVMEFVTGGELFDKIATKGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGVLKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEESNLMALYKKIFKAEFSCPPWFSSSAKKLIKRILDPNPSTRISIAEVLENDWF yelGr+lGeg+fakvk+ar++etge+vaik+ldkekvl++k++ qikreis++kl+rhpnv+r++ev+a+k kiy+v+e+v+GGelf+kia+kgrlkedearkyfqqli+avdychsrgvyhrdlkpenllld++g lkvsdfGlsal++q+redgllhttcGtP+yvaPev+++kgydgakad+WscGvilfvl+agylPfe++nl++ly+ki+kaef++p+w+s++akkli+r+ldpnp+tri+i+e+le++Wf yelGrllGegtfakvklardletgesvaikvldkekvlkaklveqikreisvlklvrhpnvvrllevlatkskiylvleyvkGGelfekiakkgrlkedearkyfqqlisavdychsrgvyhrdlkpenllldekgnlkvsdfGlsalaeqlredgllhttcGtPayvaPevlkkkgydgakadvWscGvilfvllagylPfedenlvelyrkilkaefklpkwlskeakklisrlldpnpetritieeileeeWf 463.0 1.9e-141 CAMK_CAMKL-CHK1 751 Cluster-4121.0-0F PF00069.22 229 484 1 264 YELGRTLGEGSFAKVKFARNVETGENVAIKILDKEKVLRHKMiGQIKREISTMKLIRHPNVIRMYEVMASKLKIYIVMEFVTGGELFDKIATKGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGVLKVSDFGLSALPQQVREdglLHTTCGTPNYVAPEVINNKGYdGAKADLWSCGVILFVLMAGYLPFEESNLMALYK----------KIF---KAEFSCPPWFSSSAKKLIKRILDPNPSTRISIAEVLENDWF ye ++lGeGsf+kV a++ etg+ vA+K+++kek k ++ rEi+ +k ++hpn++r+yev+ +k ++y+v+e+v ggel+d + +kg l+e+ea+k+++q++++++y+Hs+g+ HrDlKpeN+L+d +g+lK++DFGl++ ++ + l++ +gt++Y+APEv+++++y ++k+D+Ws+Gvil+ l++g pf++++ ++ ki+ k ++ + +s++ak+l+k++l+ +p++R++++e+l+++++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeney.skkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 251.6 5.2e-77 Protein kinase domain 751 Cluster-4121.0-0F PF07714.14 230 480 2 258 ELGRTLGEGSFAKVKFARNV----ETGENVAIKILDKEKvlRHKMIGQIKREISTMKLIRHPNVIRMYEVMASKLKIYIVMEFVTGGELFDKIATK---GRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGVLKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDgAKADLWSCGVILFVLMA-GYLPFEESNLMALYKKIFKA-EFSCPPWFSSSAKKLIKRILDPNPSTRISIAEVLE elg++lGeG+f++V ++ ++ +va+K+l++e+ +++ ++ +e+++mk ++hpn+++++ v+ ++ +++iv+e+v+gG+L + + +k +l+ ++ ++ +q+ ++++y +s+ + Hrdl N Ll+ n v k+sDfGL+ ++ e +++ +++apE++++k + k+D Ws Gv+l+ ++ g p+++ + + +++k+ + + ++p +++ ++l+k+ ++ +p+ R +++e++e elgkklGeGafGeVvegtlkgekekkevkvavKtlkeea..teeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkft.sksDvWsfGvllwEiftlgeepypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelve 136.5 6.3e-42 Protein tyrosine kinase 751 Cluster-4121.1-0F CAMK_CAMKL-CHK1 229 484 1 256 YELGRTLGEGSFAKVKFARNVETGENVAIKILDKEKVLRHKMIGQIKREISTMKLIRHPNVIRMYEVMASKLKIYIVMEFVTGGELFDKIATKGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGVLKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEESNLMALYKKIFKAEFSCPPWFSSSAKKLIKRILDPNPSTRISIAEVLENDWF yelGr+lGeg+fakvk+ar++etge+vaik+ldkekvl++k++ qikreis++kl+rhpnv+r++ev+a+k kiy+v+e+v+GGelf+kia+kgrlkedearkyfqqli+avdychsrgvyhrdlkpenllld++g lkvsdfGlsal++q+redgllhttcGtP+yvaPev+++kgydgakad+WscGvilfvl+agylPfe++nl++ly+ki+kaef++p+w+s++akkli+r+ldpnp+tri+i+e+le++Wf yelGrllGegtfakvklardletgesvaikvldkekvlkaklveqikreisvlklvrhpnvvrllevlatkskiylvleyvkGGelfekiakkgrlkedearkyfqqlisavdychsrgvyhrdlkpenllldekgnlkvsdfGlsalaeqlredgllhttcGtPayvaPevlkkkgydgakadvWscGvilfvllagylPfedenlvelyrkilkaefklpkwlskeakklisrlldpnpetritieeileeeWf 463.1 1.7e-141 CAMK_CAMKL-CHK1 725 Cluster-4121.1-0F PF00069.22 229 484 1 264 YELGRTLGEGSFAKVKFARNVETGENVAIKILDKEKVLRHKMiGQIKREISTMKLIRHPNVIRMYEVMASKLKIYIVMEFVTGGELFDKIATKGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGVLKVSDFGLSALPQQVREdglLHTTCGTPNYVAPEVINNKGYdGAKADLWSCGVILFVLMAGYLPFEESNLMALYK----------KIF---KAEFSCPPWFSSSAKKLIKRILDPNPSTRISIAEVLENDWF ye ++lGeGsf+kV a++ etg+ vA+K+++kek k ++ rEi+ +k ++hpn++r+yev+ +k ++y+v+e+v ggel+d + +kg l+e+ea+k+++q++++++y+Hs+g+ HrDlKpeN+L+d +g+lK++DFGl++ ++ + l++ +gt++Y+APEv+++++y ++k+D+Ws+Gvil+ l++g pf++++ ++ ki+ k ++ + +s++ak+l+k++l+ +p++R++++e+l+++++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeney.skkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 251.7 4.8e-77 Protein kinase domain 725 Cluster-4121.1-0F PF07714.14 230 480 2 258 ELGRTLGEGSFAKVKFARNV----ETGENVAIKILDKEKvlRHKMIGQIKREISTMKLIRHPNVIRMYEVMASKLKIYIVMEFVTGGELFDKIATK---GRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGVLKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDgAKADLWSCGVILFVLMA-GYLPFEESNLMALYKKIFKA-EFSCPPWFSSSAKKLIKRILDPNPSTRISIAEVLE elg++lGeG+f++V ++ ++ +va+K+l++e+ +++ ++ +e+++mk ++hpn+++++ v+ ++ +++iv+e+v+gG+L + + +k +l+ ++ ++ +q+ ++++y +s+ + Hrdl N Ll+ n v k+sDfGL+ ++ e +++ +++apE++++k + k+D Ws Gv+l+ ++ g p+++ + + +++k+ + + ++p +++ ++l+k+ ++ +p+ R +++e++e elgkklGeGafGeVvegtlkgekekkevkvavKtlkeea..teeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkft.sksDvWsfGvllwEiftlgeepypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelve 136.6 5.9e-42 Protein tyrosine kinase 725 Cluster-4121.2-0F CAMK_CAMKL-CHK1 229 484 1 256 YELGRTLGEGSFAKVKFARNVETGENVAIKILDKEKVLRHKMIGQIKREISTMKLIRHPNVIRMYEVMASKLKIYIVMEFVTGGELFDKIATKGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGVLKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEESNLMALYKKIFKAEFSCPPWFSSSAKKLIKRILDPNPSTRISIAEVLENDWF yelGr+lGeg+fakvk+ar++etge+vaik+ldkekvl++k++ qikreis++kl+rhpnv+r++ev+a+k kiy+v+e+v+GGelf+kia+kgrlkedearkyfqqli+avdychsrgvyhrdlkpenllld++g lkvsdfGlsal++q+redgllhttcGtP+yvaPev+++kgydgakad+WscGvilfvl+agylPfe++nl++ly+ki+kaef++p+w+s++akkli+r+ldpnp+tri+i+e+le++Wf yelGrllGegtfakvklardletgesvaikvldkekvlkaklveqikreisvlklvrhpnvvrllevlatkskiylvleyvkGGelfekiakkgrlkedearkyfqqlisavdychsrgvyhrdlkpenllldekgnlkvsdfGlsalaeqlredgllhttcGtPayvaPevlkkkgydgakadvWscGvilfvllagylPfedenlvelyrkilkaefklpkwlskeakklisrlldpnpetritieeileeeWf 463.1 1.7e-141 CAMK_CAMKL-CHK1 720 Cluster-4121.2-0F PF00069.22 229 484 1 264 YELGRTLGEGSFAKVKFARNVETGENVAIKILDKEKVLRHKMiGQIKREISTMKLIRHPNVIRMYEVMASKLKIYIVMEFVTGGELFDKIATKGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGVLKVSDFGLSALPQQVREdglLHTTCGTPNYVAPEVINNKGYdGAKADLWSCGVILFVLMAGYLPFEESNLMALYK----------KIF---KAEFSCPPWFSSSAKKLIKRILDPNPSTRISIAEVLENDWF ye ++lGeGsf+kV a++ etg+ vA+K+++kek k ++ rEi+ +k ++hpn++r+yev+ +k ++y+v+e+v ggel+d + +kg l+e+ea+k+++q++++++y+Hs+g+ HrDlKpeN+L+d +g+lK++DFGl++ ++ + l++ +gt++Y+APEv+++++y ++k+D+Ws+Gvil+ l++g pf++++ ++ ki+ k ++ + +s++ak+l+k++l+ +p++R++++e+l+++++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeney.skkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 251.8 4.8e-77 Protein kinase domain 720 Cluster-4121.2-0F PF07714.14 230 480 2 258 ELGRTLGEGSFAKVKFARNV----ETGENVAIKILDKEKvlRHKMIGQIKREISTMKLIRHPNVIRMYEVMASKLKIYIVMEFVTGGELFDKIATK---GRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGVLKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDgAKADLWSCGVILFVLMA-GYLPFEESNLMALYKKIFKA-EFSCPPWFSSSAKKLIKRILDPNPSTRISIAEVLE elg++lGeG+f++V ++ ++ +va+K+l++e+ +++ ++ +e+++mk ++hpn+++++ v+ ++ +++iv+e+v+gG+L + + +k +l+ ++ ++ +q+ ++++y +s+ + Hrdl N Ll+ n v k+sDfGL+ ++ e +++ +++apE++++k + k+D Ws Gv+l+ ++ g p+++ + + +++k+ + + ++p +++ ++l+k+ ++ +p+ R +++e++e elgkklGeGafGeVvegtlkgekekkevkvavKtlkeea..teeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkft.sksDvWsfGvllwEiftlgeepypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelve 136.6 5.8e-42 Protein tyrosine kinase 720 Cluster-415.0-2R RLK-Pelle_LRR-XIIIa 100 160 1 61 KDIIGSGGYGTVYKLTIDESISFAVKRLSRLSHEQDRGFERELESMGDIKHRNIVTLHGYY kdiiGsGgyGtvykl++d++ favk+l++ ++e+dr+ferele +gd+khrn+v+l+Gyy kdiiGsGgyGtvyklvlddkkafavkklakaalesdrsfereleilgdlkhrnlvklrGyy 87.0 1.1e-26 RLK-Pelle_LRR-XIIIa 161 Cluster-415.0-2R PF00069.22 99 160 3 67 NKDIIGSGGYGTVYKLT-IDESISFAVKRLSRLSHEQDR--GFERELESMGDIKHRNIVTLHGYY ++ +G+G++G+Vyk + +++ +AvK++++ + ++++ + rE++ + +kh+niv+l +++ kleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevf 33.2 2.2e-10 Protein kinase domain 161 Cluster-415.0-2R PF07714.14 99 161 3 71 NKDIIGSGGYGTVYKLTID-----ESISFAVKRLSRLSHE-QDRGFERELESMGDIKHRNIVTLHGYYT ++ +G+G +G+V++ t++ ++++ avK l++ ++e + + f +e++ m ++kh+niv l+g +t lgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvct 30.8 1.2e-09 Protein tyrosine kinase 161 Cluster-4196.0-0F CMGC_CDK-PITSLRE 1 121 172 292 LLGAREYSTAIDMWSVGCIMAELLSKEPLFSGKTEVDQLDKIFRILGTPNEAIWPGFSKLPGAKSNFVKNQLNQLRGKFPATPFTGSPVLSDAGLDLLNKLLTYDPDKRITAEAALKHEWF llga+eystaid+wsvgci+aell+keplf+gk+e+dqldkif++lgtpne+iwpg+sklp+ak +f+k++ n+lr kf+a+ f+g++vls+ag+dlln+lltydp+kritae alkhewf llgakeystaidlwsvgcilaellakeplfdgkseidqldkifkvlgtpnekiwpglsklpnakvkftkqpynklrkkftassfaggavlseagfdllnrlltydpekritaeealkhewf 202.9 4.7e-62 CMGC_CDK-PITSLRE 164 Cluster-4196.0-0F PF00069.22 2 121 169 264 LGAREYSTAIDMWSVGCIMAELLSKEPLFS---GKT----EVDQLDKIFRILGtPNEAIWPGFSKLpgaksnfvknqlnqlrgkfpatpftgspvlSDAGLDLLNKLLTYDPDKRITAEAALKHEWF l+++eys+++D+Ws+G+i++ell+++p+fs gk+ e+dql ki++ilg +++ +p s+l s+ +dll+kll++dp kR+tae +l+h+++ lkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.etkeklpeasel..............................seeakdllkkllkkdpkkRltaeellqhpyl 71.8 3.7e-22 Protein kinase domain 164 Cluster-4244.0-2F CAMK_CDPK 1 172 88 259 FDRIIQRGHYSERKAAELTKIIVGVVEACHSLGVMHRDLKPENFLLVNKDNDFSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLLKHYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGHIDFDSDPWPLISECAKDLIRKMLCMQPSERLTAHEVLCHPWI +dri++rg+yser+aa++++ i+ vv+acHs gv+hrDlKPeNfll +k++d +lkaiDFGlsvf+k+g+ ++d+vGspyyvaPEvl ++yg+eadvW+aGvilyill+gvppfwaet+++if+avlk+++df+s+pw+ +se akdl+r++L+ +p++Rlta++vL hpW+ ldrilargkyseraaakvvrqilevvaacHskgvvhrDlKPeNflltskeedaplkaiDFGlsvfvkegerledivGspyyvaPEvlkrsygkeadvWsaGvilyillcgvppfwaeteeeifkavlkaeldfksepwksvseeakdlvrrlLekdpkkRltaeqvLehpWl 270.4 1.3e-82 CAMK_CDPK 391 Cluster-4244.0-2F PF00069.22 3 172 88 264 RIIQRGHYSERKAAELTKIIVGVVEACHSLGVMHRDLKPENFLLVNKDNdfsLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVL-LKHYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKG---------HIDFDSDPWPLISECAKDLIRKMLCMQPSERLTAHEVLCHPWI ++ ++g++se++a +++k i+ +e +Hs g++HrDlKpeN+L+ +k++ lK +DFGl+ ++ ++ +t++vg+++Y+APEvl ++y++++DvW++Gvily ll+g ppf++e+++ + + l+ + +++++ + +se akdl++k+l+++p++Rlta+e+l hp++ llsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekge...lKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 153.7 3.7e-47 Protein kinase domain 391 Cluster-4244.0-2F PF07714.14 30 165 121 255 HSLGVMHRDLKPENFLLVNkdnDFSLKAIDFGLSVFF---KPGQIFTDVVGSPYYVAPEVLLK-HYGPEADVWTAGVILYILLS-GVPPFWAETQQGIFDAVLKGHIdfdSDPWPLISECAKDLIRKMLCMQPSERLTAHE +s ++Hrdl N Ll + + k DfGL+ + + ++ + ++apE+l + ++ ++DvW Gv+l+ +++ g p++ +++ +++++ +g+ + ++e ++l+++ + +p+eR t +e eskklvHrdlaarNvLlse...nkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevleklkegkr...lekpekcpeelyelmkqCweedpeeRptfke 29.6 2.6e-09 Protein tyrosine kinase 391 Cluster-4309.0-0R RLK-Pelle_RLCK-VIII 131 403 1 275 SLIGEGSYGRVYYGILKNGRAAAIKKLDASKQPDD--EFLAQVSMVSRLKHENFVELLGYCVDGNQRVLAYEFASNGSLHDILHGRKGVKGAQPGPVLSWAQRVKIAVGAAKGLEYLHEKADPHIIHRDVKSSNVLIFDDDVAKVADFDLSNQAPDMAARLHSTRVLGTFGYHAPEYAMTGQLNSKSDVYSFGVVLLELLTGRKPVDHTLPRGQQSLVTWATPKLSEDKVRQCVDARLGGEYPPKAVAKMAAVAALCVQYEADFRPNMSIVVKAL sliGeGsygrvyy++lk+g+aaa+kkld+sk++++ eflaqvs+vsrlkhen+vellgycv+g++rvlayefa++gslhdilhGrkgvkgaqpgpvlsw+qrvkiav+aa+Gleylhek++P++ihrd++ssnvl+fddd+ak+adf+lsnqapdmaarlhstrvlgtfgyhapeyamtGql++ksdvysfGvvllelltGrkpvdhtlprgqqslvtwatp+lsedkv+qcvd++l +eyppkavak+aavaalcvqyeadfrpnmsivvkal sliGeGsygrvyyavlkdgkaaavkkldkskeeesneeflaqvsvvsrlkhenlvellgycvegelrvlayefatkgslhdilhGrkgvkgaqpgpvlsweqrvkiaveaarGleylhekvqPavihrdirssnvllfdddkakiadfnlsnqapdmaarlhstrvlgtfgyhapeyamtGqltqksdvysfGvvllelltGrkpvdhtlprgqqslvtwatprlsedkvkqcvdpklkdeyppkavaklaavaalcvqyeadfrpnmsivvkal 544.4 3.1e-166 RLK-Pelle_RLCK-VIII 513 Cluster-4309.0-0R PF07714.14 132 403 6 260 LIGEGSYGRVYYGILK-----NGRAAAIKKLDASKQP--DDEFLAQVSMVSRLKHENFVELLGYCVDGNQRVLAYEFASNGSLHDILHGRkgvkgaQPGPVLSWAQRVKIAVGAAKGLEYLHEKAdphIIHRDVKSSNVLIFDDDVAKVADFDLSNQAPDMAARLHSTRVLGTFGYHAPEYAMTGQLNSKSDVYSFGVVLLELLT-GRKPvdhtlprgqqslvtwaTPKLSEDKVRQCVDARLGGEYPPKAVAKMAAVAALCVQYEADFRPNMSIVVKAL +GeG++G+V+ g+lk + a+K+l+++++ +efl ++++ ++lkh+n v+llg c+++++ ++ e++++G+L++ L+ + + + l+ + +++a+ AkG+eyL++k ++Hrd+ + NvL+ +++v+k++Df L+++ ++ ++++ + + apE ++++++sksDv+sfGv+l E++t g++p p+ls+ +v + ++++ e p k+ ++++ + C++++++ Rp+++ +v+ l klGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk......eekekltlkdllsfalqiAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep................ypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 156.7 4.2e-48 Protein tyrosine kinase 513 Cluster-4309.0-0R PF00069.22 130 337 4 200 DSLIGEGSYGRVYYGI-LKNGRAAAIKKLDASKQPDD---EFLAQVSMVSRLKHENFVELLGYCVDGNQRVLAYEFASNGSLHDILHgrkgvkgaQ------PgpvlswaQRVKIAVGAAKGLEYLHEKAdphIIHRDVKSSNVLIFDDDVAKVADFDLSNQAPDMAArlhSTRVLGTFGYHAPEYAMTGQLNSKSDVYSFGVVLLELLTGRKPVDHT ++ +GeGs+G+Vy ++ ++g+ A+Kk++ +k+ ++ ++l+ ++++ +lkh+n v+l++++ + ++++l e++++g+l+d+l+ + + kia ++gleylH+k iiHrD+K++N+Li ++++ K++DF+l++++ t + gt Y APE + + +k+Dv+s Gv+l+elltg+ p ++ leklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls........rkgslsee.......eakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsge 140.3 4.6e-43 Protein kinase domain 513 Cluster-4322.0-2R CAMK_CAMKL-CHK1 39 294 1 256 YELGKLLGCGAFAKVYHARDLRDGRSVAIKVINKKRLNnNSNLKGNIKREISIMHKLNHPNIVKLYEVLATKTKIYFVMEFVKGGELFAKVAK-GRFGEDLSRRYFQQLISALSYCHSRGVYHRDLKPENLLLDENGDLKVSDFGLCAVREQIRLDGLLHTLCGTPAYVAPEILAKRGYDGAKIDIWSSGVILFVLSAGYLPFNDPNLMNMYRKIYKGEFRCPKWMSSDLKRFLSRLLDTNPMTRITIDEIKRDPWF yelG+llG g+fakv++ardl+ g+svaikv++k+++ +++l +ikreis++++++hpn+v+l+evlatk+kiy+v+e+vkGGelf+k+ak gr+ ed +r+yfqqlisa++ychsrgvyhrdlkpenlllde+g+lkvsdfGl a+ eq+r dgllht cGtPayvaPe+l+k+gydgak d+Ws Gvilfvl agylPf+d nl+++yrki+k+ef++pkw+s+++k+++srlld+np+triti+ei++++Wf yelGrllGegtfakvklardletgesvaikvldkekvl.kaklveqikreisvlklvrhpnvvrllevlatkskiylvleyvkGGelfekiakkgrlkedearkyfqqlisavdychsrgvyhrdlkpenllldekgnlkvsdfGlsalaeqlredgllhttcGtPayvaPevlkkkgydgakadvWscGvilfvllagylPfedenlvelyrkilkaefklpkwlskeakklisrlldpnpetritieeileeeWf 419.7 3e-128 CAMK_CAMKL-CHK1 524 Cluster-4322.0-2R PF00069.22 39 294 1 264 YELGKLLGCGAFAKVYHARDLRDGRSVAIKVINKKRLNNNSNlkGNIKREISIMHKLNHPNIVKLYEVLATKTKIYFVMEFVKGGELFAKVA-KGRFGEDLSRRYFQQLISALSYCHSRGVYHRDLKPENLLLDENGDLKVSDFGLCAVREQIRLdglLHTLCGTPAYVAPEILAKRGYdGAKIDIWSSGVILFVLSAGYLPFNDPNLMN----MYRK------I---YKGEFRCPKWMSSDLKRFLSRLLDTNPMTRITIDEIKRDPWF ye + lG G+f+kVy a++ ++g+ vA+K+i+k++ +++++ ++ rEi+i++kl+hpniv+lyev+ +k+++y+v+e+v+ggel+ + kg + e+ +++++q++++l+y+Hs+g+ HrDlKpeN+L+de+g+lK++DFGl++ e+ l++ +gt+ Y+APE+l +++y ++k+D+Ws Gvil+ l +g pf++ + + ++++ i +k +++ ++ +s+++k++l++ll+ +p++R+t++e++++p++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkke..kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeney.skkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 243.0 2.2e-74 Protein kinase domain 524 Cluster-4322.0-2R PF07714.14 40 290 2 258 ELGKLLGCGAFAKVYHARDL----RDGRSVAIKVINKKRLNNNsnlKGNIKREISIMHKLNHPNIVKLYEVLATKTKIYFVMEFVKGGELFAKVAKG----RFGEDLSRRYFQQLISALSYCHSRGVYHRDLKPENLLLDENGDLKVSDFGLCAVREQIRLDGLLHTLCGTPAYVAPEILAKRGYDgAKIDIWSSGVILF-VLSAGYLPFNDPNLMNMYRKIYKGE-FRCPKWMSSDLKRFLSRLLDTNPMTRITIDEIKR elgk lG Gaf++V++++ ++ +va+K+++++ +++ k ++ +e++im+kl+hpnivkl+ v + ++++v+e+v+gG+L + k ++ + ++ +q+ ++++y +s+ + Hrdl N Ll+en k+sDfGL+ e+ ++ ++apE+l ++ + k D+Ws Gv+l+ +++ g p+++ + +++++k+ +g+ ++p+ ++++l++++++ ++++p R t++e+ + elgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateee...keefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkft.sksDvWsfGvllwEiftlgeepypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelve 128.9 1.4e-39 Protein tyrosine kinase 524 Cluster-4466.0-1R CMGC_MAPK 59 146 18 105 GLNSETNGYVAIKKIANDFHNKTDAKRSLREIKFLRHMDHENVVALKDIISPPQRESFNDVYIAYELMDTDLHQIIRSNQALSEEHWQ +++et+ vaikki++ f+n++dakr lreik+lr+++hen+v+lkd+++p+++e+f+Dvyi++elmdtdlhq+i+sn++l+eeh q avdtetgekvaikkiedvfenlidakrvlreikllrrlehenivelkdvlkpaekeefkDvyivlelmdtdlhqviksndelteehvq 117.5 5.2e-36 CMGC_MAPK 238 Cluster-4466.0-1R PF00069.22 58 145 17 100 SGLNSETNGYVAIKKIANDFHNKTDAKRSLREIKFLRHMDHENVVALKDIISPpqresFNDVYIAYELMDTD-LHQIIRSNQALSEEHW +++++et+ vA+Kki ++ +k++ k+ lrEik+l++++h+n+v l+++++ +++y+ e+++++ l+++++ +++lsee+ kaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee.....kdelylvleyveggeladllsrkgslseeea 44.9 6.2e-14 Protein kinase domain 238 Cluster-4466.0-1R PF07714.14 60 145 23 96 LNSETNGYVAIKKIANDfHNKTDAKRSLREIKFLRHMDHENVVALKDIISppQRESfndVYIAYELMDT-DLHQIIRSNqalseehW +++++ va+K++ ++ +++++ ++ l+e+k++++++h+n+v+l +++ ++e+ ++i e+++ dL++ +r++ ekekkevkvavKtlkee.ateeekeefleeakimkklkhpnivkllgvct..keep...llivteyvegGdLlkfLrkk.......e 27.3 1.3e-08 Protein tyrosine kinase 238 Cluster-4488.0-1R CMGC_MAPK 193 308 1 116 FKIQEVIGKGSYGVVCSAIDSYTREKVAIKKIHDIFEHISDAARILREIKLLRLLRHPDIVEIKHIMIPPSRRDFKDIYVVFELMESDLHQVIKANDDLTREHYQFFLYQLLRALK +k++eviGkGsygvvcsa+d+ t+ekvaikki+d+fe+ +da r+lreikllr l+h++ive+k+++ p+++++fkD+y+v+elm++dlhqvik+nd+lt+eh+q++lyqllr+lk ykleeviGkGsygvvcsavdtetgekvaikkiedvfenlidakrvlreikllrrlehenivelkdvlkpaekeefkDvyivlelmdtdlhqviksndelteehvqyllyqllrglk 180.3 3.9e-55 CMGC_MAPK 308 Cluster-4488.0-1R PF00069.22 194 308 2 112 KIQEVIGKGSYGVVCSAIDSYTREKVAIKKIHDIFEHISDAARILREIKLLRLLRHPDIVEIKHIMIPpsrrdFKDIYVVFELMESD-LHQVIKANDDLTREHYQFFLYQLLRALK + +e +G+Gs+G+V +a+++ t+++vA+Kki + ++ ++lrEik+l+ l+hp iv++++++ +++y+v+e++e + l+++++++ l+ e+ +++++q+l++l+ ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee.....kdelylvleyveggeladllsrkgslseeeakkiakqilegle 69.3 2.2e-21 Protein kinase domain 308 Cluster-4488.0-1R PF07714.14 194 303 2 113 KIQEVIGKGSYGVVCSAIDS----YTREKVAIKKIHDIFEHISdAARILREIKLLRLLRHPDIVEIKHIMIppsrrDFKDIYVVFELMES-DLHQVIKAN---DDLTREHYQFFLYQL ++++ +G+G++G V++++ + ++ kva+K++++ ++ + +++l+e+k+++ l+hp iv++ +++ + + +++v+e++e+ dL++ ++++ + lt ++ f +q+ elgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateee.keefleeakimkklkhpnivkllgvct.....keepllivteyvegGdLlkfLrkkeekekltlkdllsfalqi 37.9 7.7e-12 Protein tyrosine kinase 308 Cluster-4521.0-2R CMGC_CDK-CRK7-CDK9 1 145 141 285 IADFGLASTFDPNNKQPMTSRVVTLWYRPPELLLGATDYGVGVDLWSAGCILAELFARKPIMTGRTEVEQLHRIFKLCGSPTEEYWKKSKLPHATIFKPQQAYKRCIAETFKDFPKSSIPLIDTLLAIDPAERRTATAALKSEFF iadfGla++fd+++kqp+tsrvvtlWyrpPelllGat+ygv+vdlWs+Gcilael+a kpi++Grteveqlh+ifklcGsP+eeyWkk+klp+at+fkpq+ ykr+++etfk++++s++ l+++ll++dP++r ta+ alkseff iadfGlatsfdadkkqpltsrvvtlWyrpPelllGatkygvavdlWsvGcilaellagkpilpGrteveqlhkifklcGsPseeyWkkvklplatsfkpqkpykrrlketfkelsesalellekllsldPekrgtakdalkseff 245.8 3.3e-75 CMGC_CDK-CRK7-CDK9 291 Cluster-4521.0-2R PF00069.22 1 145 139 264 IADFGLASTFDPNNKqpMTSRVVTLWYRPPELLlGATDYGVGVDLWSAGCILAELFARKPIMT---GRT----EVEQLHRIFKLCGSPTEEYWKKSKLphatifkpqqaykrciaetfkdfPKSSIPLIDTLLAIDPAERRTATAALKSEFF i+DFGla+ ++ ++k +ts+v+t +Y++PE+l ++++y+ vD+Ws+G+il+el+++kp++ g++ e++ql++i+k+ g +e++ ++s+l +++ + l++ ll+ dp +R ta+ +l+++++ itDFGlakelesssk..ltsfvgtreYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeasel.......................seeakdllkkllkkdpkkRltaeellqhpyl 83.8 8e-26 Protein kinase domain 291 Cluster-4521.1-2R CMGC_CDK-CRK7-CDK9 1 145 141 285 IADFGLASTFDPNNKQPMTSRVVTLWYRPPELLLGATDYGVGVDLWSAGCILAELFARKPIMTGRTEVEQLHRIFKLCGSPTEEYWKKSKLPHATIFKPQQAYKRCIAETFKDFPKSSIPLIDTLLAIDPAERRTATAALKSEFF iadfGla++fd+++kqp+tsrvvtlWyrpPelllGat+ygv+vdlWs+Gcilael+a kpi++Grteveqlh+ifklcGsP+eeyWkk+klp+at+fkpq+ ykr+++etfk++++s++ l+++ll++dP++r ta+ alkseff iadfGlatsfdadkkqpltsrvvtlWyrpPelllGatkygvavdlWsvGcilaellagkpilpGrteveqlhkifklcGsPseeyWkkvklplatsfkpqkpykrrlketfkelsesalellekllsldPekrgtakdalkseff 245.7 3.7e-75 CMGC_CDK-CRK7-CDK9 304 Cluster-4521.1-2R PF00069.22 1 145 139 264 IADFGLASTFDPNNKqpMTSRVVTLWYRPPELLlGATDYGVGVDLWSAGCILAELFARKPIMT---GRT----EVEQLHRIFKLCGSPTEEYWKKSKLphatifkpqqaykrciaetfkdfPKSSIPLIDTLLAIDPAERRTATAALKSEFF i+DFGla+ ++ ++k +ts+v+t +Y++PE+l ++++y+ vD+Ws+G+il+el+++kp++ g++ e++ql++i+k+ g +e++ ++s+l +++ + l++ ll+ dp +R ta+ +l+++++ itDFGlakelesssk..ltsfvgtreYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeasel.......................seeakdllkkllkkdpkkRltaeellqhpyl 83.7 8.9e-26 Protein kinase domain 304 Cluster-4521.2-2R CMGC_CDK-CRK7-CDK9 125 254 1 130 FEKIDKIGQGTYSNVYKARDAITGKIVALKKVRFDNLEPESVRFMAREILILRRLDHPNVVKLHGLVTSRMSCSLYLVFDYMDHDLAGLASSPAIKFTEPQVKCFMHQLLSGLEHCHTRHVLHRDIKGSN fek++kiG+Gtys+vyka+d tgkivalkkvr+dnle+esvrfmarei ilr+ldhpnv+kl+glvts++s+slylvf+ymdhdl+glas+p +kf+epqvkc+++qllsGlehch+r+vlhrdikgsn feklekiGeGtysevykakdletgkivalkkvrldnleeesvrfmareikilrkldhpnvikleglvtsklsgslylvfeymdhdltglasapdlkfsepqvkcylkqllsGlehchsrgvlhrdikgsn 233.3 2.2e-71 CMGC_CDK-CRK7-CDK9 254 Cluster-4521.2-2R PF00069.22 125 254 1 128 FEKIDKIGQGTYSNVYKARDAITGKIVALKKVRFDNLEPESVRFMAREILILRRLDHPNVVKLHGLVTSrmSCSLYLVFDYMDHD-LAGLASsPAIKFTEPQVKCFMHQLLSGLEHCHTRHVLHRDIKGSN +ek+ k+G+G++++Vyka+++ tgkivA+Kk++ ++ + ++ + ++rEi il++l+hpn+v+l + +++ + +lylv++y++++ la l s +++e ++k +++q+l+gle++H ++++HrD+K +N yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee..kdelylvleyveggeladlls.rkgslseeeakkiakqilegleylHskgiiHrDlKpeN 109.8 9.6e-34 Protein kinase domain 254 Cluster-4521.2-2R PF07714.14 127 254 3 134 KIDKIGQGTYSNVYKARDA----ITGKIVALKKVRFDNLEPESVRFMArEILILRRLDHPNVVKLHGLVTSRMScsLYLVFDYMDH-DLAGLASSP--AIKFTEPQVKCFMHQLLSGLEHCHTRHVLHRDIKGSN +k+G+G++++V++++ + va+K+++ ++ e e+ +f+ e+ i+++l+hpn+vkl+g++t++ + l++v++y+++ dL + k+t ++ +f++q+ +G+e+ + ++++Hrd+ N lgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefle.eakimkklkhpnivkllgvctkeep..llivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarN 56.8 1.3e-17 Protein tyrosine kinase 254 Cluster-4531.0-1R CMGC_CK2 97 382 1 286 YEVVRKVGRGKYSEVFEGINVINNEKCIIKILKPVKKKKIKREIKILQNLCGGPNIVKLLDIVRDQHSKTPSLIFEYVNSTDFKILYPTLTDYDIRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPNKEYNVRVASRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDELNAYLNKYHLELDPQLEALVGRHSRKPWSRFINSDNQHLVSPEAIDFLDKLLRYDHQDRLTAKEAMAHPYF yevvrkvgrgkysevfeginv n+ekc+ikilkpvkkkkikreikilqnl+ggpnivklldivrdq+sktpslifeyvn+tdfk+lyptltdydiryyiyellkaldychs+gimhrdvkphnv+idhe rklrlidwglaefyhp+keynvrvasryfkgpellvdlqdydysld+wslgcm+ag+ifrkepffyghdn+dqlvkiakvlgtdelnaylnky+leldpqlealvgrhsrkpws+fin+dnqhlvspea+dfldkllrydhq+rltakea+ahpyf yevvrkvgrgkysevfeginvaneekcvikilkpvkkkkikreikilqnlsggpnivklldivrdqesktpslifeyvnntdfkvlyptltdydiryyiyellkaldychsrgimhrdvkphnvlidhekrklrlidwglaefyhpgkeynvrvasryfkgpellvdlqdydysldlwslgcmlaglifrkepffyghdnydqlvkiakvlgtdelnaylnkyrleldpqlealvgrhsrkpwskfinadnqhlvspealdfldkllrydhqerltakealahpyf 619.6 5.1e-189 CMGC_CK2 466 Cluster-4531.0-1R PF00069.22 97 382 1 264 YEVVRKVGRGKYSEVFEGINVINNEKCIIKILKPVKKKKIK-----REIKILQNLCgGPNIVKLLDIVRDqhSKTPSLIFEYVNSTDFKILYP---TLTDYDIRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDhELRKLRLIDWGLAEFYHPNKEYNVRVASRYFKGPELLvDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGH------DNHDQLVKIAKVLGTDELNAYLNKYHleldpqlealvgrhsrkpwsrfinsdnqhlvSPEAIDFLDKLLRYDHQDRLTAKEAMAHPYF ye+++k+G+G++++V+++++ ++++ +K++k k+kk k rEikil++l pniv+l++++++ +++ l++eyv+ ++++ l+ +l++ +++ +++++l++l+y+Hs+gi+HrD+Kp+N++id e ++l+++D+Gla+ ++ +++++ +v++r++ PE+l + ++y+ + D+WslG++++ ++++k+pf + + dql+ki+k+lg+ +++ ++ s+ea+d+l+kll++d+++Rlta+e+++hpy+ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklk.hpnivrlyevfee..kdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLid.ekgelKitDFGlakelessskltsfvgtreYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeasel...............................seeakdllkkllkkdpkkRltaeellqhpyl 219.5 3.2e-67 Protein kinase domain 466 Cluster-4531.0-1R PF07714.14 99 288 3 204 VVRKVGRGKYSEVFEGINV----INNEKCIIKILKPVKKK----KIKREIKILQNLcGGPNIVKLLDIVRdqHSKTPSLIFEYVNSTDFKI-LYP-----TLTDYDIRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHELrKLRLIDWGLAEFYHPNKEYNVRVASR---YFKGPELLVDLQdYDYSLDMWSLGCMFAGMIFRKE + +k+G+G+++eV+eg+ ++ k+++K+lk +++ ++ +e+ki+++l pnivkll ++ ++++ +++eyv++ d++ L +lt d+ +++++ k+++y +s+ ++Hrd+ Nv+++++ + ++ D GLa+ + ++ey+++ ++ + pE l + + + + D+Ws G + ++ + e lgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkkl.khpnivkllgvct..keepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenk.vvkisDfGLardiekddeykkkeeaklpvkWmapEslkekk.ftsksDvWsfGvllwEiftlge 67.4 7.9e-21 Protein tyrosine kinase 466 Cluster-4549.0-0R RLK-Pelle_PERK-1 53 321 2 270 NLLGQGGFGYVHKGILRNGREVAVKSLKSGSGQGEREFQAEVEIISRVHHRHLVSLVGYCIAEQTRMLVYEFVPNSTLEFHLHGNGRPVMEWQVRLRIAIGSAKGLAYLHEDCHPRIIHRDIKAANILLDNNFEAMVADFGLAKLSSDNFTHVSTRVMGTFGYLAPEYASSGKLSEKSDVFSFGVMLLELITGRRPVDLTNRIMEDSLVDWARPLMEQAMEDGSYEELVDPRLEGNYDPHEMGRMVACAAASIRHSARRRPRMSQIVRA nllG+GGfGyv+kG+l++g+evavk+lk+gsgqGeref+aeveiisrvhhrhlvslvGyciae++r+lvyefvpn+tle+hlhg+++pv++w+ rl+ia+g+akglaylhedchP+iihrdikaanilld++fea+vadfGlakl+sd+ thvstrvmGtfGylaPeyassGkl++ksdvfsfGv+llelitGr+pvd ++ ++e+slv+warpl+++a+e+g+++elvd+rle +yd +e+ rm+++aaa++rhsa++rp+msq+vra nllGeGGfGyvykGvladgkevavkqlkagsgqGerefkaeveiisrvhhrhlvslvGyciaeeqrllvyefvpnktlelhlhgkekpvldwetrlkialgaakglaylhedchPkiihrdikaanilldekfeakvadfGlaklasdtnthvstrvmGtfGylaPeyassGkltdksdvfsfGvvllelitGrkpvdaseelaeeslvewarpllakaleegdfdelvdkrlekkydekelarmieaaaaavrhsakkrpkmsqvvra 514.5 3.9e-157 RLK-Pelle_PERK-1 491 Cluster-4549.0-0R PF07714.14 52 320 4 258 ANLLGQGGFGYVHKGILR-----NGREVAVKSLKSGSGQG-EREFQAEVEIISRVHHRHLVSLVGYCIAEQTRMLVYEFVPNSTLEFHLHGN-GRPVMEWQVRLRIAIGSAKGLAYLHEDchpRIIHRDIKAANILLDNNFEAMVADFGLAKLS-SDNFTHVSTRVMGTFGYLAPEYASSGKLSEKSDVFSFGVMLLELIT-GRRPvdltnrimedslvdwarplmEQAMEDGSYEELVDPRLEGNYDPHEMGRMVACAAASIRHSARRRPRMSQIVR + lG+G fG V++g+l+ + +vavK+lk+++ + ++ef e++i+++++h+++v+l+g c+ e++ ++v e+v++ +L+ +L+ + ++ ++ + l++a+ AkG++yL++ +++Hrd+ a N+Ll++n + ++DfGLa+ +d+ ++++++ + ++apE +++k+++ksDv+sfGv+l E++t g++p + +++ + e ++ + + + + ++ ++++++++Rp+++++v+ gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLesk...klvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep....................ypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelve 156.6 4.6e-48 Protein tyrosine kinase 491 Cluster-4549.0-0R PF00069.22 50 253 2 201 SQANLLGQGGFGYVHKGI-LRNGREVAVKSLKSGSGQGERE--FQAEVEIISRVHHRHLVSLVGYCIAEQTRMLVYEFVPNSTLEFHLHGNGRpVMEWQVRlRIAIGSAKGLAYLHEDChprIIHRDIKAANILLDNNFEAMVADFGLAKLSSDNFThvSTRVMGTFGYLAPEYASSGKLSEKSDVFSFGVMLLELITGRRPVDLTN ++ + lG+G+fG V k++ ++g++vAvK +k + + ++e +++E++i+ +++h+++v l++++ +++++lv e+v++ +l+ +l+ +g + e++++ +ia ++gl+ylH+ + iiHrD+K +NiL+d++ e +++DFGlak + + + t ++gt YlAPE ++ + s+k+Dv+s Gv+l+el+tg+ p ++ ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgs.lseeeak.kiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgek 150.2 4.4e-46 Protein kinase domain 491 Cluster-4599.0-0R RLK-Pelle_RLCK-VIIa-2 2 244 38 275 SRRGLQGHKEWVTEVNFLGIAQHPNLVKLVGYCAEDDergmQRLLIYEYMPKRSVQDHLSSRYQASLPWITRLKIAQDAARGLAYLHeGMEFQIIFRDFKSSNILLDDDWCAKLSDFGLARLGPPDGLSHISTAVVGTIGYAAPEYIHTGHLTSKSDVWSYGVFLYELITGRRPLDSNRPKNEQKLLEWVRPHLADSKRFEQVLDPRLDGKYSIRSAQKLAAIANRCLVRHPKNRPRMSEVLE +++glqghkew++ev+fLg +hpnlvkl+Gyc+edd +rll+yEym+k+s+++hl++r +++l+W trlkia +aA+gla+Lh +e ++i+Rdfk+sniLld+d+ aklsdfgla+ gp ++ +h+st+v+gt gYaaPey++tGhlt+ksDv+s+Gv l+el+tGrr ld++rpk+eqkl++w+rp+l+d++++e+++Dprl+g+ys+++aqk+a++a++Cl ++pk+Rp+msev+e nkeglqghkewlaevefLgqlshpnlvkliGycledd....erllvyEymakgslenhlfrrssealsWetrlkialgaAkglafLh.eaekkviyRdfkasniLldedfnaklsdfglakegpeedkthvstrvmgtygYaaPeyvatGhltaksDvysfGvvllelltGrraldkkrpkeeqklvdwarpllsdkrkleriiDprlegqysakaaqkvaklalkClskepkeRpkmsevve 374.4 2.2e-114 RLK-Pelle_RLCK-VIIa-2 323 Cluster-4599.0-0R PF00069.22 9 244 42 260 HKEWVTEVNFLGIAQHPNLVKLVGYCAEdderGMQRLLIYEYMPKRSVQDHLSsrYQASLPWITRLKIAQDAARGLAYLHEGMefqIIFRDFKSSNILLDDDWCAKLSDFGLARLGPPDGLshiSTAVVGTIGYAAPEYIHTGHLTSKSDVWSYGVFLYELITGRRPLDSNRPKN--EQKLLE------WVRPHLADSKRFEQVldprldgkysirsAQKLAAIANRCLVRHPKNRPRMSEVLE +k+ ++E+++l +hpn+v+l++++ e +++l+ ey+++ +++d+ls + sl+ + kia+ ++gl+ylH+ ii+rD K++NiL+d++ K++DFGla+ + t +vgt Y APE +++ + ++k+DvWs+Gv lyel+tg+ p+ +++ k+ e++l + +++ ++++ +++ +++ + +++l + pk+R+ ++e+l+ ekkvlrEikilkklkhpnivrlyevfee....kdelylvleyveggeladlls..rkgslseeeakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeasel.............seeakdllkkllkkdpkkRltaeellq 135.9 1.1e-41 Protein kinase domain 323 Cluster-4599.0-0R PF07714.14 9 244 45 258 HKEWVTEVNFLGIAQHPNLVKLVGYCAEDDErgmqRLLIYEYMPKRSVQDHLSSR-YQASLPWITRLKIAQDAARGLAYLHEGmefQIIFRDFKSSNILLDDDWCAKLSDFGLARLGPPDGLSHISTAVVGTIGYAAPEYIHTGHLTSKSDVWSYGVFLYELIT-GRRPldsnrpkneqkllewvRPHLADSKrFEQVLDPRLDGKYSIRSAQKLAAIANRCLVRHPKNRPRMSEVLE ++e ++e++++ +hpn+vkl+g c ++++ l++ ey+++ +++++L ++ +++l + l++a++ A+G++yL++ +++ rd + N+Ll+++ ++k+sDfGLar d + ++ + + apE ++++++tsksDvWs+Gv l+E++t g++p p+l +++ + + l+ + + ++l+ + ++C+ ++p++Rp+++e++e keefleeakimkklkhpnivkllgvctkeep....llivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLesk...klvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep................ypglsnee.vleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelve 131.0 3.1e-40 Protein tyrosine kinase 323 Cluster-4607.0-0F RLK-Pelle_LRR-XI-1 1 265 4 266 IGQGGVGTVYKAVLPSTQVIAVKKLasNREGNVNNIENSFRAEISTLGNIRHRNIVKLYGFCYHQGSNLLLYEYMARGSLGELLYRESC-DLDWPTRFSIALGAAEGLAYLHHDCRPKIIHRDIKPNNILLDEKFEAHVGDFGLAKVID-MPQSKSMSAVAGSYGYIAPEYAYTMKVTEKCDIYSYGVVLLELLTGKMPVQP-IEQGGDLVTWVRNYirQHSLSSGILDSRLnLKDESTVNHMINVLKIALLCTSMSPFDRPTMREVV iG+Gg G+VYka l+s +v+aVKkl + + + ++ e+sf+ae++tlg+irhrnivkl+gfc+++ ++ll+yeym++gsLgell +++ ldW++R++ia+g+AegLaYlhhdc+p+i+HrD+k++niLLd++fea+v+dfglakv+d +s+s+savagsyGYiaPeyayt+kvtek+D+YS+GvvlLel+tgk+pv++ ++++ d+v+wv++ +++ + ilD++l ++e++ ++m++vlk+allcts sp +RPtmrevv iGrGgsGkVYkaelksgevvaVKkl..eaakskekseksfeaevktlgkirhrnivkllgfcsseeakllvyeymengsLgellhgkkkkeldWeaRlkiavgvAegLaYlhhdcsppivHrDvkssniLLdsefeakvadfglakvldekkeseslsavagsyGYiaPeyaytlkvteksDvYSfGvvlLelvtgkkpvdeefgesvdivkwvaek..kkekveeilDekl.avseaaeeemlkvlkvallctsespeeRPtmrevv 369.2 7.9e-113 RLK-Pelle_LRR-XI-1 322 Cluster-4607.0-0F PF00069.22 1 265 7 259 IGQGGVGTVYKAV-LPSTQVIAVKKLASNREGNVNNieNSFRAEISTLGNIRHRNIVKLYGFCYHQGSNLLLYEYMARGSLGELLYRESCdLDWPTRFSIALGAAEGLAYLHHDCrpkIIHRDIKPNNILLDEKFEAHVGDFGLAKVIDMPQSksMSAVAGSYGYIAPEYAYTMKVTEKCDIYSYGVVLLELLTGKMPVQPIEQGGDLVTWVRNYIRQHSLSSgilDSRLNLKDESTVnhMINVLKIALLCTSMSPFDRPTMREVV +G+G++G+Vykav + + +AvKk+ +++ + ++ +++++Ei+ l +++h+niv+ly++++++ + +l+ ey+ g+l +ll r+++ l+ + +ia +egl+ylH+ + iiHrD+Kp+NiL+dek e ++DFGlak ++ ++ ++ + g+ Y+APE + ++++k+D++s+Gv+l+elltgk+p + ++ + + +++ + + +++++l+ +s++ +++++ + ++ p +R+t++e++ lGeGsfGkVykaveketgkivAvKkikkekakkkke..kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgs.lseeeakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg...etkeklpeasel..seeakdllkkllkkdpkkRltaeell 171.5 1.4e-52 Protein kinase domain 322 Cluster-4607.0-0F PF07714.14 1 266 7 258 IGQGGVGTVYKAVLP-----STQVIAVKKLasnREGNVNNIENSFRAEISTLGNIRHRNIVKLYGFCYHQGSNLLLYEYMARGSLGELLYRE--SCDLDWPTRFSIALGAAEGLAYLHHDcrpKIIHRDIKPNNILLDEKFEAHVGDFGLAKVI-DMPQSKSMSAVAGSYGYIAPEYAYTMKVTEKCDIYSYGVVLLELLT-GKMPvqpieqggdlvtwVRNYiRQHSLSSGIlDSRLNLKDESTVNHmiNVLKIALLCTSMSPFDRPTMREVVL +G+G G+V+++ l +++ +avK+l +e++ ++ +++f e++++ +++h+nivkl+g+c+++++ l++ ey++ G+L + L ++ + l+ + +s+al A+G++yL++ k++Hrd+ N+Ll+e+ + ++DfGLa+ i ++ + k+ + ++ ++apE ++k+t+k D++s+Gv+l E++t g++p ++++ +++++ + + +++ +l+ +++++ ++ ++ C + +p +Rpt++e+v lGeGafGeVvegtlkgekekkevkvavKtl...keeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLesk...klvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep.............ypgl.sneevlekl.kegkrlekpekcpe..elyelmkqCweedpeeRptfkelve 146.0 8.1e-45 Protein tyrosine kinase 322 Cluster-4613.0-1F TKL_CTR1-DRK-2 130 310 1 181 LTIGEQIGQGSCGTVYHALWYGSDVAVKVFSRQEYTDDVIFSFRQEVPLMKRLRHPNILLFMGAVTSPERLCIVTEFLPRGSLFRLLQRNTAKLDWRRRIHMALDVARGMNYLHHFNPPIVHRDLKSSNLLVDKNWAVKVGDFGLSRLKHETYLTTKTGKGTPQWMAPEVLRNESADEKYD ltige+iGqGs+g+vy+a w+Gsdvavkvf++q+++++++ +fr+ev lmkrlrhpn++lfmGavt+p+rl+ivteflprgslfrll+r+++kld+rrr+++aldvarG+nylh+ +ppivhrdlkssnllvdknw+vkv+dfGlsrlk+et+l++k+++Gtp+wmapevlrne+adek d ltigeriGqGsfgevyraewkGsdvavkvflkqdlseealeefrkevslmkrlrhpnvvlfmGavtkpqrlsivteflprgslfrllerkksklderrrlklaldvarGlnylhklsppivhrdlkssnllvdknwtvkvadfGlsrlkaetflsskstaGtpewmapevlrneaadeksd 337.7 3.9e-103 TKL_CTR1-DRK-2 317 Cluster-4613.0-1F PF07714.14 130 309 1 187 LTIGEQIGQGSCGTVYHALWY------GSDVAVKVFsRQEYTDDVIFSFRQEVPLMKRLRHPNILLFMGAVTSPERLCIVTEFLPRGSLFRLLQRN--TAKLDWRRRIHMALDVARGMNYLHHFNppIVHRDLKSSNLLVDKNWAVKVGDFGLSRLK--HETYLTTKTGKGTPQWMAPEVLRNESADEKY l++g+++G+G+ G+V+++ ++ +vavK++ ++e+t++ +f +e+ +mk+l+hpni+ ++g++t+ e+l+ivte+++ G+L + L+++ ++kl+ ++ +++al++A+Gm+yL++ + +vHrdl + N L+++n vk++DfGL+r +++y +++++k +WmapE+l++++ +k lelgkklGeGafGeVvegtlkgekekkevkvavKtl.keeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskk..lvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsks 153.7 3.5e-47 Protein tyrosine kinase 317 Cluster-4613.0-1F PF00069.22 132 310 3 179 IGEQIGQGSCGTVYHAL--WYGSDVAVKVFSRQEYTDDVIFSFRQEVPLMKRLRHPNILLFMGAVTSPERLCIVTEFLPRGSLFRLLQRNTAkLDWRRRIHMALDVARGMNYLHHFNppIVHRDLKSSNLLVDKNWAVKVGDFGLSRLKHETYLtTKTGKGTPQWMAPEVLRNESADEKYD e++G+Gs G+Vy a+ + g vAvK++++++ +++ ++++E+ ++k+l+hpni+ ++++++++++l++v+e+++ g+l++ll+r+++ l+ ++ ++a +++g++ylH+ + i+HrDlK++N+L+d++ +K++DFGl++ +++ +++ gt++++APEvl++++ ++k D kleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgs.lseeeakkiakqilegleylHskg..iiHrDlKpeNiLidekgelKitDFGlakelesssk.ltsfvgtreYlAPEvlkeneyskkvD 148.0 2.2e-45 Protein kinase domain 317 Cluster-4642.0-0R RLK-Pelle_SD-2b 26 295 1 267 KEKLGAGGFGAVYRGVLTNRTVAAVKQLEGIEQGEKQFRMEVATISSTHHLNLVRLIGFCSEGRHRLLVYEFMKNGSLDNFLFvsEEHSGKFLTWESRYNIALGTARGITYLHEECRDCIVHCDIKPENILLDENYTAKVSDFGLAKLVNPKDHRyrTLKSVRGTRGYLAPEWLANLPITSKSDVYSYGMVLLEVVSGKRNFDV--SSETNNVKFSMWAYEEFEKGNFDNIVDKRLpRDEIDMEQVIRAIKVCFWCIQEQPSHRPMMGKVVQ +eklG+Ggfg+Vy+gvl+++t+ avK+le++eqgek+fr+ev++i+s++h nLvrl+Gfcseg++rllvye+++ngsLd++lf +++s k+l+w++r++ialg+Arg++yLHeecr++i+hcdikpeniLlde++++k++dfGlakl++ + +r +l +vrGtrgYlapew++nl+it+k+DvYsyG+vlle+vsg+rn++ s+e+++v++ ++a+e++e+g++ ++vd+rl ++e+d+e+v r++kv +wciqe++s+RP m +vv+ seklGeGgfgsVykgvledetkvavKklekveqgekefraevsvigsiqhvnLvrllGfcsegekrllvyeyvengsLdkllf..kkkskkvlewktrlkialgvArglayLHeecrekiihcdikpeniLldekfepkiadfGlakllkrdqsr..vlttvrGtrgYlapewisnlaitekvDvYsyGvvllelvsgrrnveekeseeeesvllvklaaekleegevaelvdarl.egevdleevervvkvalwciqedeskRPsmsevvk 391.8 1.1e-119 RLK-Pelle_SD-2b 372 Cluster-4642.0-0R PF00069.22 26 295 4 260 KEKLGAGGFGAVYRGV-LTNRTVAAVKQLEGIEQGE---KQFRMEVATISSTHHLNLVRLIGFCSEGRHRLLVYEFMKNGSLDNFLFvseeHSGKfLTWESRYNIALGTARGITYLHEECrdcIVHCDIKPENILLDENYTAKVSDFGLAKLVNPKDHryrtLKSVRGTRGYLAPEWLANLPITSKSDVYSYGMVLLEVVSGKRNFDVSSETNNVKFSMWAYEEFEKGNFdnIVDKR------LprdeidmeqVIRAIKVCFWCIQEQPSHRPMMGKVVQ +eklG G+fG Vy++v +++ AvK+++ ++ + k++++E++ + +++h n+vrl+++++e ++++lv e++++g+l+++l ++g+ l+ e +ia +++g+ ylH+++ i+H+D+KpeNiL+de+ K++DFGlak ++ + + l+s+ gtr YlAPE+l + ++++k+Dv+s+G++l+e+++gk f ++++++v+ + e++ k +++ l a++++ ++++++p++R+ + +++q leklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls....rkgs.lseeeakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk....ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg..etkeklpeasel.........seeakdllkkllkkdpkkRltaeellq 176.8 3.4e-54 Protein kinase domain 372 Cluster-4642.0-0R PF07714.14 25 297 3 260 FKEKLGAGGFGAVYRGVLT-----NRTVAAVKQLEG-IEQ-GEKQFRMEVATISSTHHLNLVRLIGFCSEGRHRLLVYEFMKNGSLDNFLFVSeeHSGKFLTWESRYNIALGTARGITYLHEECrdcIVHCDIKPENILLDENYTAKVSDFGLAKLVnPKDHRYRTLKSVRGTRGYLAPEWLANLPITSKSDVYSYGMVLLEVVS-GKRNfdvssetnnvkfsmwaYEEFEKGNFDNIVD--KRLPRDEIDMEQVIRAIKvcfWCIQEQPSHRPMMGKVVQML +++klG+G fG V++g l+ +++ avK+l+ ++ +++f e++++++++h n+v+l+g+c+++++ l+v e++++G+L++fL + ++ + lt ++ +++al A+G+ yL+++ +vH d+ N+Ll+en ++k+sDfGLa+ + kd++y++ ++ + ++apE l + +tsksDv+s+G++l E+++ g++ y+++++ ++ + ++ krl++ e e++ + +k C++e+p++Rp++ ++v+ l lgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk..eekekltlkdllsfalqiAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLardi.ekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep................ypglsneevleklkegkrlekpekcpeelyelmk...qCweedpeeRptfkelvekl 160.1 4e-49 Protein tyrosine kinase 372 Cluster-4652.0-1R RLK-Pelle_RLCK-VIIa-2 1 102 6 108 GGFGCVFKGWIEENGTAPVKPGTGLTVAVKTLNHDGLQGHKEWLAEVNFLGDLVHPNLVKLIGYCIEEDQRLLVYEFMPRGSLENHLFRRSL-PLPWSIRMKI GgfG+v+kg+i+e+ +a++k+g+gl+vavk+ln++glqghkewlaev+fLg l hpnlvkliGyc+e+d+rllvyE+m++gslenhlfrrs +l+W++r+ki GgfGsvykgvidektkaelkageglavavkklnkeglqghkewlaevefLgqlshpnlvkliGycledderllvyEymakgslenhlfrrssealsWetrlki 164.0 3.1e-50 RLK-Pelle_RLCK-VIIa-2 102 Cluster-4652.0-1R PF07714.14 1 90 10 95 GGFGCVFKGWIEEngtapVKPGTGLTVAVKTLNHDGLQG-HKEWLAEVNFLGDLVHPNLVKLIGYCIEEDQRLLVYEFMPRGSLENHLFRR G fG V++g +++ k + ++vavKtl+++ + ++e l e++++ +l hpn+vkl+g c++e++ l+v e+++ G+L+++L ++ GafGeVvegtlkg.....ekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk 56.3 1.9e-17 Protein tyrosine kinase 102 Cluster-4652.0-1R PF00069.22 21 89 21 91 PGTGLTVAVKTLNHDGLQGHKE--WLAEVNFLGDLVHPNLVKLIGYCIEEDQRLLVYEFMPRGSLENHLFR tg +vAvK+++++ + ke l+E+++l l hpn+v+l++++ e+d+++lv e+++ g+l+++l r ketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsr 39.1 3.5e-12 Protein kinase domain 102 Cluster-4656.0-1F AGC-Pl 1 63 190 257 EMLTGKPPFIGGNREKIQQKVIKDKIKLPSFLSSEAHSLLKGLLHKEQSKRLGS-----DEIKGHKWF emltgkppf++ n++k+qqk++kdkiklp+flss+a+sllkgll+k+ +krlgs +eik hkwf emltgkppfvaknkqklqqkivkdkiklpkflssdaksllkgllqkdpekrlgsgpsgseeikkhkwf 87.4 7.8e-27 AGC-Pl 155 Cluster-4656.0-1F PF00069.22 1 63 189 264 EMLTGKPPFIGGNREKIQQKVIKD-------------KIKLPSFLSSEAHSLLKGLLHKEQSKRLGSDEIKGHKWF e+ltgkppf g ++++ ++k +++ k++ +s ls+ea +llk ll+k+++kRl+ +e++ h+++ elltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 29.7 2.6e-09 Protein kinase domain 155 Cluster-4741.0-1R RLK-Pelle_RLCK-VI 216 479 2 267 NLIGQGGCNSVYKGFLSDGKPVAIKILRSS-KEAWKDFMLEVDIMTTLKHKRIVPLLGICVEHTNLISVYDFLSNGSLEENLHGNRKKS-VLQWEVRFKIAVGIAEALNYLHSECPKPVIHRDVKSSNILLTDELEPQLCDFGLAIWGPTTASFLTDRDVVGTFGYLAPEYFMYGKVSDKIDVYAFGVVLLELLTGRKPIGLETPKGQESLVMWAKPTLESGDVKDILDQNLEEDIGEDQLQRMALATRLCLKQSARLRPKMAEIL nl+G+Gg+++vykg l+dgk va+k+l++s +e+ k+f+ e++i+++l+hk++v+llG+cv++++l+ vy++ls+Gslee+Lhg++kk+ +l+We+R+k+AvG+a+al+ylH++c ++viHrDvk+sniLl+++ epql+DFGla w p++as l+ +dv+GtFGylapeyfm+Gkv++k+dvyafgvvlLel+tgrkpi +++kg+eslv+wakp le++++k+++d++le++ e++l+r++la+ lc+++sa+ rp+++e+l nlvGkGgasevykgkledgklvavkrlkkseeekekeflaeleiisslshknvvkllGvcvdeeglllvyeylseGsleelLhgkkkkkelleWeeRykvAvGvakaleylHegcerrviHrDvkasniLlsedfepqlsDFGlakwlpekashllvkdveGtFGylapeyfmhGkvnektdvyafgvvlLelitgrkpidsksakgkeslvlwakplleekklkelvdpkleteadeeelerlvlaaslcirksakrrpslkevl 387.7 2e-118 RLK-Pelle_RLCK-VI 591 Cluster-4741.0-1R PF00069.22 215 426 4 210 ANLIGQGGCNSVYKGF-LSDGKPVAIKILRSSKEAWK---DFMLEVDIMTTLKHKRIVPLLGICVEHTNLISVYDFLSNGSLEENLHgnRKKSVLQWEVRfKIAVGIAEALNYLHSECpkpVIHRDVKSSNILLTDELEPQLCDFGLAIWGPTTASfltDRDVVGTFGYLAPEYFMYGKVSDKIDVYAFGVVLLELLTGRKPIGLETPKGQESLVM + +G+G+ +Vyk++ ++gk vA+K+++ +k+ k +++ E+ i+ +lkh++iv l++++ e+++l+ v +++++g+l++ l+ rk+s+ ++e++ kia i+e+l+ylHs++ +iHrD+K++NiL++++ e +++DFGla ++ + +++vgt YlAPE + ++s k+Dv++ Gv+l+elltg+ p e+ k + + + leklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls..rkgslseeeak.kiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekel 150.4 3.9e-46 Protein kinase domain 591 Cluster-4741.0-1R PF07714.14 216 482 5 260 NLIGQGGCNSVYKGFLS-----DGKPVAIKILRS--SKEAWKDFMLEVDIMTTLKHKRIVPLLGICVEHTNLISVYDFLSNGSLEENLHGNRKKSVLQWEVRFKIAVGIAEALNYLHSecpKPVIHRDVKSSNILLTDELEPQLCDFGLAIWGPTTASFLTDRDVVGTFGYLAPEYFMYGKVSDKIDVYAFGVVLLELLT-GRKPigletpkgqeslvmwaKPTLESGDVKDILDQNLEEDIGEDQLQRMALATRLCLKQSARLRPKMAEILEIL + +G+G +V++g l+ + va+K+l++ ++e+ ++f+ e++im++lkh++iv llg+c+++ +l+ v +++++G+L++ L+ +++k+ l+ + +++a+ iA++++yL+s k ++Hrd+ + N+Ll+++ +++DfGLa ++ + ++++ + ++apE ++++k++ k Dv++fGv+l E++t g++p p+l++ +v + l+++ + + e+ ++++ + C++++++ Rp+++e++e l kklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLes...kklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep................ypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 145.3 1.4e-44 Protein tyrosine kinase 591 Cluster-4745.0-2R RLK-Pelle_LRR-III 1 138 124 264 NTKSSNIFLNSEQYGCVGDLGLAKMIAFPLM---RLERYHGPEVQNSKHLSQASDVYSFGILILELLMRKSPINSAGENEACDLVKLVNSINHKDQTAKVFDVELLRDPNIKEQMVKMLEIGMSCVAKTPKKRPKMSEVVK n kssni+l+++ +++ d+gLa+++a r++ y+ PE++++++ sq sDVYsfG+++LEll+ ksp +++ e+e dl+k+v+s+ ++++ta+vfdvel+++ +++e++v++l+++++Cva++p+kRpkm+evvk nlkssniLldadlearisdygLarllasaaaasaralgyraPElakarkasqksDVYsfGvvlLElltgkspskasseeeevdlpkwvrsvveeektaevfdvelvkekeaeeelvellqvalaCvaaspekRpkmkevvk 140.3 5.3e-43 RLK-Pelle_LRR-III 144 Cluster-4745.0-2R PF00069.22 3 138 125 260 KSSNIFLNSEQYGCVGDLGLAKMIAFPL-----MRLERYHGPEVQNSKHLSQASDVYSFGILILELLMRKSPINSAGENE-----ACDLVKLVNSINhkdqtakvfdVELLRDPNIKEQMVKMLEIGMSCVAKTPKKRPKMSEVVK K++Ni++++++ ++D+Glak + + ++Y PEv ++++ s+++Dv+s G++++ell++k p ++ ++e + +l+k+++ ++ + + p+ +e +++++ ++++k+pkkR+ ++e+++ KpeNiLidekgelKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg..........etkeklpeaselseeakdllkkllkkdpkkRltaeellq 49.4 2.6e-15 Protein kinase domain 144 Cluster-4745.0-2R PF07714.14 5 139 133 259 SNIFLNSEQYGCVGDLGLAKMI--------AFPLMRLERYHGPEVQNSKHLSQASDVYSFGILILELLM-RKSPinsageneacdlvklVNSINHKDQTAKVFDVELLRDPNIKEQmvKMLEIGMSCVAKTPKKRPKMSEVVKR N++l++++ ++D GLa+ i ++ pE+ ++k+++++sDv+sfG+l+ E++ ++p ++++++++ ++k+ + + l+ p+ ++ ++ e+ ++C++++p++Rp+++e+v++ rNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep...............ypglsneevleklkegkrlekpekcpe..elyelmkqCweedpeeRptfkelvek 44.2 9.5e-14 Protein tyrosine kinase 144 Cluster-4750.0-1R RLK-Pelle_RLCK-IV 57 325 2 271 IIGEGGFGAVYKAELPDGQVVAIKRAKKKEHFDALRAEFKSEVELLAKIDHRNLVKLLGFVDKGDERLIITEYVPNGTLREHLDGRKGKILDFYQRLEISIDVAHGLTYLHLYAEKQIIHRDVKSSNVLLTERMRAKVADFGFARTGEMNSDKAYVSTQVKGTVGYLDPEYMRTYQLTSKSDVFSFGVLLIEILTGRRPVDLKRPLDDRVTIKWAFRKYNEGRCLEMLDPMMK-ERVDEEIVEKMFGLAIQCVAPTRDDRPDMKSVGEQL ig+Ggfg+vyk++l dG+vvaikrakk+++ ++l+aef+seve+l+k++h+nlvkllg+++++derl+++eyv+nG+lrehldg +gkild+ +rlei+idvah+ltylhlya+++iihrd+kssn+Llte++rakvadfgfar+g +++++ vstqvkgt+GyldPey++tyqLt+ksdv+sfGvLL+e+ltgrrP++lkr+ d+r+t++Wa++k++eg+ e+ldp+++ ++++++++ek++ la+qcvaptr +rP+mk v e+l kigqGgfgtvykgklrdGkvvaikrakkdafekrlsaefrsevevlskvehlnlvkllgyleeederllvveyvanGnlrehldglegkildlstrleiaidvahaltylhlyadrpiihrdikssniLlteslrakvadfgfarlgpseegathvstqvkgtaGyldPeylktyqLteksdvysfGvLLvelltgrrPielkrasderitvrWalkkfkegevveildpklertsaslsvlekvlelafqcvaptrkerPsmkevaekl 441.4 8.8e-135 RLK-Pelle_RLCK-IV 348 Cluster-4750.0-1R PF07714.14 55 325 4 260 SQIIGEGGFGAVYKAELP-----DGQVVAIKRAKKKEHFDAlRAEFKSEVELLAKIDHRNLVKLLGFVDKGDERLIITEYVPNGTLREHLDGR-KGKILDFYQRLEISIDVAHGLTYLHlyaEKQIIHRDVKSSNVLLTERMRAKVADFGFARTGeMNSDKAYVSTQVKGTVGYLDPEYMRTYQLTSKSDVFSFGVLLIEILT-GRRPvdlkrplddrvtikwaFRKYNEGRCLEMLDPMMKERVDEEIVEKMFGLAIQCVAPTRDDRPDMKSVGEQL ++ +GeG fG V++++l + + va+K k++ + ++ ++ef +e++++ k++h+n+vkllg++ k+++ li+teyv++G+L+++L + + + l++ + l++++++A+G+ yL+ +k+++Hrd+ + NvLl+e++ +k++DfG ar+ +++d+ +++++ k v ++ pE +++ ++tsksDv+sfGvll+Ei+t g++p ++++++ ++le+l+ + + e++ e++ l qC++ + ++Rp++k++ e+l gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateee.keefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLe...skklvHrdlaarNvLlsenkvvkisDfGLardi.ekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep................ypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 180.7 2.1e-55 Protein tyrosine kinase 348 Cluster-4750.0-1R PF00069.22 53 324 2 261 SRSQIIGEGGFGAVYKAE-LPDGQVVAIKRAKKKEHFDALRAEFKSEVELLAKIDHRNLVKLLGFVDKGDERLIITEYVPNGTLREHLDgRKGKiLDFYQRLEISIDVAHGLTYLHlyaEKQIIHRDVKSSNVLLTERMRAKVADFGFARTGEMNSDkayvSTQVKGTVGYLDPEYMRTYQLTSKSDVFSFGVLLIEILTGRRPVDLKRPLDDRvtiKWAFRK-YN-----EgrclemlDPMMKERVDEEIVEKMFGLAIQCVAPTRDDRPDMKSVGEQ ++ + +GeG+fG Vyka +g+ vA+K+ kk++ + + ++ +E+++l+k++h+n+v+l++++ + de+++++eyv++g+l ++l rkg+ l+ + +i +++gl ylH +k+iiHrD+K++N+L++e+ K++DFG+a+ e +s+ t++ gt Yl PE +++ + ++k+Dv+s Gv+l+e+ltg+ p ++ ++ + +++ ++ + + +k ++++e+ e++ l ++++ ++ +R+ ++++ ++ ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls.rkgs.lseeeakkiakqilegleylH...skgiiHrDlKpeNiLidekgelKitDFGlakelesssk....ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekv...ekeldqlekilkilg.......etkeklpeaselseeakdllkkllkkdpkkRltaeellqh 168.7 1e-51 Protein kinase domain 348 Cluster-4775.0-1F CMGC_CDK-PITSLRE 1 197 30 226 KKVKMEKEREGFPLTALREINILLSCHHPYIVDVKEVVIGSNLDSIFMVMEYMEHDLKGLMETMKQPFSQSEVKCLMLQLLEGVKYLHDNWVLHRDLKTSNLLLNNQGELKICDFGLARQYGSPLKQYTQLVVTLWYRAPELLLGAKQYSTAIDMWSLGCIMAELLSKEPLFNGKTEIDQLDKIVKMLGGPNAKIRQ kkvk+ekeregfplt+lreinills+hhp ivdvkevv+gs+ldsif+v+ey+ehdlkgl+e+mk+pfsqsevkclmlqllegvkylhdnwvlhrdlktsnlllnn+gelkicdfglarqygsplk+ytq vvtlwyrapelllgak+ystaid+ws+gci+aell+keplf+gk+eidqldki+k+lg pn ki kkvklekeregfpltslreinillslhhpsivdvkevvvgskldsiflvleylehdlkgllesmkrpfsqsevkclmlqllegvkylhdnwvlhrdlktsnlllnnrgelkicdfglarqygsplkeytqevvtlwyrapelllgakeystaidlwsvgcilaellakeplfdgkseidqldkifkvlgtpnekiwp 393.5 3.8e-120 CMGC_CDK-PITSLRE 245 Cluster-4775.0-1F PF00069.22 1 210 30 242 KKVKMEKEREGFPLTALREINILLSCHHPYIVDVKEVVIGsnLDSIFMVMEYMEHD-LKGLMEtMKQPFSQSEVKCLMLQLLEGVKYLHDNWVLHRDLKTSNLLLNNQGELKICDFGLARQYGSPLKqYTQLVVTLWYRAPELLlGAKQYSTAIDMWSLGCIMAELLSKEPLFN---GKT----EIDQLDKIVKMLGGPNAKIRQNEKISHGAYNQLS Kk+k ek+++ ++lrEi+il +++hp+iv ++ev+ d++++v+ey+e++ l+ l++ k+ +s++e+k ++ q+leg++ylH++ ++HrDlK++N+L++++gelKi+DFGla+++ s k +t+ v+t +Y+APE+l ++++ys+++D+WslG+i++ell+++p+f+ gk+ e+dql ki+k+lg + k+++++++s+ a + l+ KkikkekakkkkekkvlrEikilkklkhpnivrlyevfee..kdelylvleyveggeladlls.rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk.ltsfvgtreYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllk 198.2 1.1e-60 Protein kinase domain 245 Cluster-4775.0-1F PF07714.14 14 170 46 206 LTALREINILLSCHHPYIVDVKEVVIgsNLDSIFMVMEYMEH-DLKGLMETM--KQPFSQSEVKCLMLQLLEGVKYLHDNWVLHRDLKTSNLLLNNQGELKICDFGLARQY--GSPLKQYTQLVVTLWYRAPELLLGAKqYSTAIDMWSLGCIMAELLS--KEP l+e++i+ +++hp iv + v++ + +++++v+ey+e+ dL+ +++ k++++ +++ +++lq+ +G++yL+++ ++Hrdl + N Ll+++ ki+DfGLar+ + k+ ++ + + + apE l k ++++ D+Ws G ++ E+++ +ep eefleeakimkklkhpnivkllgvct..keepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekk.ftsksDvWsfGvllwEiftlgeep 105.6 1.7e-32 Protein tyrosine kinase 245 Cluster-483.0-2F CAMK_CAMKL-CHK1 142 396 1 256 YEIGRLLGQGNFAKVYYGKNLKTGQNVAIKVINKEKVLKVGLMDQTKREISVMGMVKHPNAVQLYEVMATKTKIYFIMEYAKGGELFHKVAK-GRLKEGIARKYFQQLIDVVGFCHSRGVYHRDLKPENLLLDENGALKVSDFGLSALTESKGQDGLLHTTCGTPAYVAPEVLSRKGYDGGKADIWSCGVILFVLLAGYLPFNDSNVVHMYRKICKADYKFPSWFPSDVRRLLSRILDPNPNTRISIAKIMESSWF ye+GrllG+g+fakv+++++l+tg++vaikv++kekvlk +l++q kreisv+ +v+hpn v+l+ev+atk+kiy+++ey+kGGelf+k+ak grlke arkyfqqli+ v +chsrgvyhrdlkpenlllde+g lkvsdfGlsal+e++ +dgllhttcGtPayvaPevl++kgydg kad+WscGvilfvllagylPf+d+n+v++yrki+ka++k+p+w+ +++++l+sr+ldpnp+tri+i++i+e++Wf yelGrllGegtfakvklardletgesvaikvldkekvlkaklveqikreisvlklvrhpnvvrllevlatkskiylvleyvkGGelfekiakkgrlkedearkyfqqlisavdychsrgvyhrdlkpenllldekgnlkvsdfGlsalaeqlredgllhttcGtPayvaPevlkkkgydgakadvWscGvilfvllagylPfedenlvelyrkilkaefklpkwlskeakklisrlldpnpetritieeileeeWf 438.6 5.1e-134 CAMK_CAMKL-CHK1 661 Cluster-483.0-2F PF00069.22 142 396 1 264 YEIGRLLGQGNFAKVYYGKNLKTGQNVAIKVINKEKVLKVGLmDQTKREISVMGMVKHPNAVQLYEVMATKTKIYFIMEYAKGGELFHKVA-KGRLKEGIARKYFQQLIDVVGFCHSRGVYHRDLKPENLLLDENGALKVSDFGLSALTESKGQdglLHTTCGTPAYVAPEVLSRKGYdGGKADIWSCGVILFVLLAGYLPFN----DSNVVHMYRK------I---CKADYKFPSWFPSDVRRLLSRILDPNPNTRISIAKIMESSWF ye + lG+G+f+kVy +++ +tg+ vA+K+i+kek k +++ rEi+++ +khpn v+lyev+ +k+++y+++ey++ggel++ + kg l+e a+k+++q++ + ++Hs+g+ HrDlKpeN+L+de+g lK++DFGl++ es+ + l++ +gt+ Y+APEvl++++y + k+D+Ws+Gvil+ ll+g pf+ +++v +++++ i k +++ +s +++++++ll+++l+ +p++R++++++++++++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeney.skkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 240.2 1.6e-73 Protein kinase domain 661 Cluster-483.0-2F PF07714.14 143 392 2 258 EIGRLLGQGNFAKVYYGKNL----KTGQNVAIKVINKEKVLKVglMDQTKREISVMGMVKHPNAVQLYEVMATKTKIYFIMEYAKGGELFHKVAKG----RLKEGIARKYFQQLIDVVGFCHSRGVYHRDLKPENLLLDENGALKVSDFGLSALTESKGQDGLLHTTCGTPAYVAPEVLSRKGYDgGKADIWSCGVILFVLLA-GYLPFNDSNVVHMYRKIcKAD--YKFPSWFPSDVRRLLSRILDPNPNTRISIAKIME e+g+ lG+G+f++V+ g+ k+ ++va+K++++e+ + +++ +e+++m +khpn v+l+ v+ + ++++++ey++gG+L + + k +l+ ++ +q+ + + + +s+ + Hrdl N Ll+en k+sDfGL+ +e++ + +++ ++apE+l++k + k+D+Ws Gv+l+ ++ g p+++ + ++++k+ k++ + p+ p+++ +l+++ ++ +p+ R ++++++e elgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateee..keefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkft.sksDvWsfGvllwEiftlgeepypglsneevlekl.kegkrlekpekcpeelyelmkqCweedpeeRptfkelve 127.1 4.7e-39 Protein tyrosine kinase 661 Cluster-4855.0-0R RLK-Pelle_LRR-VI-2 232 489 1 258 NIISTYDDvATVFKGTLSSGVEIAVVSTTITSSKDWSKRSELAYRKKIDSFSQINHKNYINLIGYCEEDSPFVRTMVFEYAPNGTLFEHLHVPEVEHLNWSVRMRILMGTAYCLEYMHDLKPPMAHSNLTSKDIFLTDDYAAKIAEIGFWAELVAKSKNTS-QNDSEHSETPADLDTNIYCFGILLLETISGRVPSSKEQGPILNWASEYLSDKKSYTSLIDPTLTSFKNNELDIICEIINNCIQKDARKRPSMAEIVK nii + d atv+kGtlssGvEiavvs++++s+kdWsk++el +rkk++++s++nHkn +nl+Gycee++pf R +vfEYa+nGtlfehLH+ e+ehl+W+ r+ri mG+aycleymh+L+Pp+ahsnl+s+ i+ltddyaaK+++++++ e ++k+k+++ ++ ++++e+ adl++n+y fg+llle+isGr+p+s+e+g + +waseyl+d+k++++l+Dptl+sfk++el+ +ce++++C+++d++krPsm+e+++ niigsssd.atvykGtlssGvEiavvsiavasakdWskklelsfrkkveaLsrvnHknlvnllGyceeeepftRmlvfEYasnGtlfehLHnkeaehldWaarlriimGiaycleymheLnPpvahsnlssssiyltddyaaKvsdlevlkeklekekkekseekesseessadlesnvysfgvllleiisGrlpeseekgslvewaseyledekelaelvDptlksfkeeelealcevvkeClkedekkrPsmrevte 375.0 1.6e-114 RLK-Pelle_LRR-VI-2 599 Cluster-4855.0-0R PF07714.14 241 491 13 260 ATVFKGTLS---SGVEIAVVSTTITSSKDWSKrsELAYRKKIDSFSQINHKNYINLIGYCEEDSPfvRTMVFEYAPNGTLFEHLHVP-EVEHLNWSVRMRILMGTAYCLEYMHDLKppMAHSNLTSKDIFLTDDYAAKIAEIGFWAELVAKSKNTSQNDSEH----------SETPADLDTNIYCFGILLLETIS-GRVPsskeqgpilnwaSEYLSDKKSYTSLIDPTLTSFKNNELDIICEIINNCIQKDARKRPSMAEIVKKL ++V++gtl+ + e+ v+ t++++++ ++ + + + ++ +++++h+n ++l+g c +++p +v+ey+++G+L ++L+ e e+l+ + +++ + A +ey+++ k + H +l++++++l+++ +ki+ G ++ +++ +++++++ +e+ + +++fG+ll E ++ g+ p + ls+++ ++ l + + + +++ + + e++++C+++d+++Rp+++e+v+kl GeVvegtlkgekekkevkvavKtlkeeateee..keefleeakimkklkhpnivkllgvctkeep..llivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskk..lvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep............ypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 75.2 3.3e-23 Protein tyrosine kinase 599 Cluster-4855.0-0R PF00069.22 241 489 13 260 ATVFKGTLSSGVEIAVVSTTITSSKDWSKRseLAYRKKIDSFSQINHKNYINLIGYCEEDSPFVrtMVFEYAPNGTLFEHLHvpEVEHLNWSVRMRILMGTAYCLEYMHDLKppMAHSNLTSKDIFLTDDYAAKIAEIGFWAELVAKSKNTSQNDSEH-------SETPADLDTNIYCFGILLLETISGRVPSSKEQGPILNW--ASEYLSDKKS--YTSLIDPTLTSFknneLDIICEIINNCIQKDARKRPSMAEIVK ++V+k++ ++ +i +v + +++++ +k+ ++++ i + +++h+n ++l++++ee++ ++ +v+ey+++g+l+++l+ + +l+ + +i+ ++ ley+H+ + + H l ++ i+++++ Ki+ G+ +el +sk ts+ +++ +e++ + + ++ G++l+e ++g+ p s+e+g ++ + + + k t++ p+ +++ + + ++++++++kd +kR++++e+++ GkVykaveketgkivAvKkikkekakkkke..kkvlrEikilkklkhpnivrlyevfeekdely..lvleyveggeladlls..rkgslseeeakkiakqilegleylHskg..iiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeasel....seeakdllkkllkkdpkkRltaeellq 57.1 1.2e-17 Protein kinase domain 599 Cluster-4875.0-2R RLK-Pelle_DLSV 490 754 2 266 NKIGEGGFGSVYKGKLKNDKMAAIKVLSAGSKQGVREFLTEIQVISDTQHENLVKLYGCCVEGNHRILVYNYLENNSLAQTLIGgHRSGIQFSWQTRVRVCVGVAKGLAYLHDELRPPIVHRDIKASNILLDKDLSAKISDFGLAKLIPENMTHVST-RVAGTLGYLAPEYAMKGQLTRKADIYSFGVLLIEIITGRCNTNSLLPAEEKYILERAWLLHEQRELVQLVDPTLNGDFDPEQACRFLKIGLLCAQEFPKLRPSMTSVV nk+GeGgfg+vYkgkl+++k A+k ls+ skqg++ef +e+++i++ qh+nlvkL+gcc+eg++++lvy+ylen+sL ++l+ +++ +++W+tr++++ g+a+Gl+YLh+e r+ i+hrD+KasNiLLdk++++ki+DFGla+l+ e+ t++st rv+gtlgY+aPeya++gql+ k+D+ysfGvl++ei++G+ n+++ e++++le aw l+e+++l++lvd++l+ +++ e++ r+++i+llc qe p+ rp+m++vv nklGeGgfgkvYkgkledgkevAvkrlskkskqgkeefknevvliaklqhrnlvkLlgcciegeekllvyeylenksLdkflfd.eekkkeldWktrfkiikgiarGllYLheesrlkiihrDlKasNiLLdkemnpkiaDFGlarlfeedqteastkrvvgtlgYmaPeyalegqlseksDvysfGvlvleivsGkknsslkeeeeaeelleeawklweeekllelvdkslkeeaekeevlrcieiallcvqekpekrptmsevv 345.9 1.1e-105 RLK-Pelle_DLSV 884 Cluster-4875.0-2R PF07714.14 490 755 5 258 NKIGEGGFGSVYKGKLK-----NDKMAAIKVLSAGSKQG-VREFLTEIQVISDTQHENLVKLYGCCVEGNHRILVYNYLENNSLAQTLIGgHRSGIQFSWQTRVRVCVGVAKGLAYLHDELrppIVHRDIKASNILLDKDLSAKISDFGLAKLI-PENMTHVSTRVAGTLGYLAPEYAMKGQLTRKADIYSFGVLLIEIIT-GRCNtnsllpaeekyileraWLLHEQRELVQLVDPTLNGDFDPEQACRFLKIGLLCAQEFPKLRPSMTSVVR +k+GeG fG+V++g+lk ++ a+K+l++++++ +efl+e++++++++h+n+vkl+g+c+++++ ++v +y+e+++L + L +++ +++ ++ +++++ +AkG++yL+++ +vHrd+ a N+Ll+++ +kisDfGLa+ i ++ ++++++ + ++apE +++++t k+D++sfGvll+Ei+t g+ + +++e+++ ++ + + + ++ ++ C +e p+ Rp+++++v+ kklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrk.keekekltlkdllsfalqiAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep................ypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelve 161.3 1.7e-49 Protein tyrosine kinase 884 Cluster-4875.0-2R PF00069.22 488 689 3 198 PINKIGEGGFGSVYKGK-LKNDKMAAIKVLSAGSKQGVRE--FLTEIQVISDTQHENLVKLYGCCVEGNHRILVYNYLENNSLAQTLIgghRSGIqFSWQTRVRVCVGVAKGLAYLHDELrppIVHRDIKASNILLDKDLSAKISDFGLAKLIPENMThvSTRVAGTLGYLAPEYAMKGQLTRKADIYSFGVLLIEIITGRCNTN ++k+GeG+fG+Vyk++ +++k+ A+K+++ +++ +e +l+Ei+++ ++h+n+v+ly+++ e ++++lv +y+e+++la+ l r+g+ +s ++ +++ +++gl+ylH++ i+HrD+K +NiL+d++ Ki+DFGlak + ++ + t + gt YlAPE + + ++k+D++s Gv+l+e++tg+ + kleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls...rkgs.lseeeakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfs 159.9 5e-49 Protein kinase domain 884 Cluster-4934.0-2R RLK-Pelle_RLCK-VI 91 166 1 75 DNIVGKGGFAEVYRGVLEDGQAIAVKTLSKTAndERKEKEFLTEIGTLGHVCHPNVTALLGCCIDN-GLYLIFQFSS +n+vGkGg +evy+g+ledg+++avk l+k++ e+kekefl+e+++ ++ h+nv++llG+c+d+ gl+l+++++s enlvGkGgasevykgkledgklvavkrlkkse..eekekeflaeleiisslshknvvkllGvcvdeeglllvyeyls 81.7 4.4e-25 RLK-Pelle_RLCK-VI 167 Cluster-4934.0-2R PF07714.14 91 164 4 82 DNIVGKGGFAEVYRGVLE-----DGQAIAVKTLSKTANDERkEKEFLTEIGTLGHVCHPNVTALLGCCID-NGLYLIFQF ++ +G+G f+eV++g l+ + + +avKtl+++a++e+ ++efl+e+ ++ ++ hpn+ +llg+c++ + l++++++ gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateee.keefleeakimkklkhpnivkllgvctkeepllivtey 44.2 9.4e-14 Protein tyrosine kinase 167 Cluster-4934.0-2R PF00069.22 90 164 3 79 SDNIVGKGGFAEVYRGV-LEDGQAIAVKTLSKTANDERKEKEFLTEIGTLGHVCHPNVTALLGCCID-NGLYLIFQF ++ +G+G+f++Vy++v e+g+ +AvK+++k ++++kek++l+Ei l ++ hpn+ l++++ + + lyl++++ kleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvley 43.3 1.9e-13 Protein kinase domain 167 Cluster-4991.0-0F CMGC_CK2 117 402 1 286 YEVVRKVGRGKYSEVFEGVHTTNNEKCIIKILKPVKKKKIKREIKILQNLCGGPNIVKLLDIVRDQQSKTPSLIFEYVNNTDFKVLYPTLSDFDIRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHEQRKLRLIDWGLAEFYHPGKEYNVRVASRYFKGPELLVDLQDYDYSLDLWSLGCMFAGMIFRKEPFFYGHDNYDQLVKIAKVLGTDELNAYLHKYRLELDPHLAALVGRHSRKPWTKFINADNQHLAVPEAIDFVDKLLRYDHQERPTAKEAMAHPYF yevvrkvgrgkysevfeg++++n+ekc+ikilkpvkkkkikreikilqnl+ggpnivklldivrdq+sktpslifeyvnntdfkvlyptl+d+diryyiyellkaldychs+gimhrdvkphnv+idhe+rklrlidwglaefyhpgkeynvrvasryfkgpellvdlqdydysldlwslgcm+ag+ifrkepffyghdnydqlvkiakvlgtdelnayl+kyrleldp+l+alvgrhsrkpw+kfinadnqhl++pea+df+dkllrydhqer takea+ahpyf yevvrkvgrgkysevfeginvaneekcvikilkpvkkkkikreikilqnlsggpnivklldivrdqesktpslifeyvnntdfkvlyptltdydiryyiyellkaldychsrgimhrdvkphnvlidhekrklrlidwglaefyhpgkeynvrvasryfkgpellvdlqdydysldlwslgcmlaglifrkepffyghdnydqlvkiakvlgtdelnaylnkyrleldpqlealvgrhsrkpwskfinadnqhlvspealdfldkllrydhqerltakealahpyf 613.8 2.9e-187 CMGC_CK2 518 Cluster-4991.0-0F PF00069.22 117 402 1 264 YEVVRKVGRGKYSEVFEGVHTTNNEKCIIKILKPVKKKKIK-----REIKILQNLCgGPNIVKLLDIVRDQQSKTpsLIFEYVNNTDFKVLYP---TLSDFDIRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDhEQRKLRLIDWGLAEFYHPGKEYNVRVASRYFKGPELLvDLQDYDYSLDLWSLGCMFAGMIFRKEPFF------YGHDNYDQLVKIAKVLGTDELNAYLHKYRleldphlaalvgrhsrkpwtkfinadnqhlaVPEAIDFVDKLLRYDHQERPTAKEAMAHPYF ye+++k+G+G++++V+++v+++++++ +K++k k+kk k rEikil++l pniv+l+++++++++ + l++eyv++++++ l+ +ls+ +++ +++++l++l+y+Hs+gi+HrD+Kp+N++id e+++l+++D+Gla+ ++ +++++ +v++r++ PE+l + ++y+ + D+WslG++++ ++++k+pf + ++dql+ki+k+lg+ +++ + +ea+d+++kll++d+++R+ta+e+++hpy+ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklk.hpnivrlyevfeekdely..lvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLid.ekgelKitDFGlakelessskltsfvgtreYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeasel...............................seeakdllkkllkkdpkkRltaeellqhpyl 221.8 6.6e-68 Protein kinase domain 518 Cluster-4991.0-0F PF07714.14 119 306 3 202 VVRKVGRGKYSEVFEGVHT----TNNEKCIIKILKPVKKK----KIKREIKILQNLcGGPNIVKLLDIVRdqQSKTPSLIFEYVNNTDFKV-LYP-----TLSDFDIRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHeQRKLRLIDWGLAEFYHPGKEYNVRVASR---YFKGPELLVDLQdYDYSLDLWSLGCMFAGMIFR + +k+G+G+++eV+eg + +++ k+++K+lk +++ ++ +e+ki+++l pnivkll ++ ++++ +++eyv++ d++ L +l+ d+ +++++ k+++y +s+ ++Hrd+ Nv++++ +++ ++ D GLa+ + +ey+++ ++ + pE l + + + + D Ws G + ++ + lgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkkl.khpnivkllgvct..keepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlse.nkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekk.ftsksDvWsfGvllwEiftl 69.3 2.1e-21 Protein tyrosine kinase 518 Cluster-4997.0-2F CMGC_MAPK 26 154 161 288 DYVATRWYRAPELCGSfFSKYTPAIDIWSIGCIFAEILTGKPLFPGKNVVHQLDLITDLLGSPSSECLSRIRNEKARRYLSTMRKKAPVPLSQKFPNVDPLALRLLERLIAFDPKDRLSAEEALADPYF +yv+trwyraPel+ s +skYt+aiD+Ws+GCifae+lt+kplfpgk+vv+ql+lit+l+G+ps+e+l+++r+ekarryl++++kka+++l++kfp+vd+lal+Llerl+afdPk+r++aeeala+py+ eyvvtrwyraPellls.sskYtsaiDvWsvGCifaelltrkplfpgkdvvdqlkliteliGtpseedlesvrsekarrylkklpkkakkslkkkfpkvdelaldLlerllafdPkkritaeealahpyl 196.2 5.2e-60 CMGC_MAPK 178 Cluster-4997.0-2F PF00069.22 27 154 157 264 YVATRWYRAPELCGSffSKYTPAIDIWSIGCIFAEILTGKPLFP---GKN----VVHQLDLITDLLGspsseclS---------RIrnekarrylstmrkkapvplsqkfpnvDPLALRLLERLIAFDPKDRLSAEEALADPYF +v+tr+Y+APE+ ++ ++y++++D+Ws+G+i++e+ltgkp+f+ gk+ ++ql i+++lg + ++ a++ll++l++ dpk+Rl+aee+l++py+ fvgtreYlAPEvlke..neyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.......etkeklpeasel...........................seeakdllkkllkkdpkkRltaeellqhpyl 72.9 1.7e-22 Protein kinase domain 178 Cluster-4997.1-0R CMGC_MAPK 1 142 23 161 TGEKVAIKKIDNVFEHVSEATRILREIKLLRLLRHPDIVEIKHIMLPSCRREFKDIYVVFELMETDLHHVIKTNDDLTPGHHQFFLYQLLRALKYIHSANVFHRDLKPKNILANADCKLKICDFGLARASfgdAPSAVFWTV tgekvaikki +vfe++++a+r+lreikllr l+h++ive+k+++ p+ ++efkD+y+v+elm+tdlh+vik+nd+lt h+q++lyqllr+lky+hsanv+hrDlkpkn+l+na+cklkicDfGlar++ ++++ ++t tgekvaikkiedvfenlidakrvlreikllrrlehenivelkdvlkpaekeefkDvyivlelmdtdlhqviksndelteehvqyllyqllrglkylhsanvlhrDlkpknlllnancklkicDfGlarsa...ssetdllte 229.2 4.6e-70 CMGC_MAPK 146 Cluster-4997.1-0R PF00069.22 1 129 23 147 TGEKVAIKKIDNVFEHVSEATRILREIKLLRLLRHPDIVEIKHIMLPscrreFKDIYVVFELMETD-LHHVIKTNDDLTPGHHQFFLYQLLRALKYIHSANVFHRDLKPKNILANADCKLKICDFGLARA tg++vA+Kki++ + ++ +++lrEik+l+ l+hp iv++++++ +++y+v+e++e++ l+++++++ l++ + +++++q+l++l+y+Hs++++HrDlKp+NiL + + +lKi+DFGla+ tgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee.....kdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlake 121.8 2e-37 Protein kinase domain 146 Cluster-4997.1-0R PF07714.14 3 130 29 154 EKVAIKKIDNVFEHvSEATRILREIKLLRLLRHPDIVEIKHIMLpscrrEFKDIYVVFELMET-DLHHVIKTN---DDLTPGHHQFFLYQLLRALKYIHSANVFHRDLKPKNILANADCKLKICDFGLARAS kva+K++++ ++ +e +++l+e+k+++ l+hp iv++ +++ + + +++v+e++e dL++ ++++ + lt + f +q+ ++++y++s ++ Hrdl +N+L + + + ki+DfGLar+ vkvavKtlkeeate.eekeefleeakimkklkhpnivkllgvct.....keepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardi 78.0 4.4e-24 Protein tyrosine kinase 146 Cluster-5044.0-2R RLK-Pelle_LRR-XIIIa 1 97 170 267 EYMQSGRATEKTDVYSFGVLVLEIVSGRRPTDATFIEKGLNIVGWLNYLVSENKQREIVDPHC-EGVRAESLDTLLSIANQCVSSSPEDRPTMHRVVQ ey++sGratek+dvysfGv++le++sg+rptd++++ekgln+v+w+++lv+en+++eivd ++ e v++e+l+++l+ia +cvs++pe+rptm++vv+ eylesGratekgdvysfGvvllellsgkrptdesllekglnlvewvkalvkenreeeivdkslleevekeeleavleialkcvsaepeerptmdkvvk 129.3 1.4e-39 RLK-Pelle_LRR-XIIIa 137 Cluster-5044.0-2R PF07714.14 1 98 176 259 EYMQSGRATEKTDVYSFGVLVLEIVS-GRRPtdatfiekglnivgwlnylVSENKQREIVDPHCEGVRAE----SLDTLLSIANQCVSSSPEDRPTMHRVVQI E +++++ t+k+Dv+sfGvl+ Ei++ g++p +++ +++e+++ eg r e ++l ++ +qC++++pe+Rpt++++v+ EslkekkftsksDvWsfGvllwEiftlgeep...................ypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelvek 36.8 1.7e-11 Protein tyrosine kinase 137 Cluster-5071.0-0R TKL-Pl-6 1 254 7 253 SGTYGTVYHGKWRGSDVAIKRLKKSCFTgrsseqERLAVEFWREAEILSKLHHPNVVAFYGVVQDGPGGTLATVTEYMVNGSLRHVLISKERHLDRRKRLIIAMDAAFGMEYLHSRNIVHFDLKCDNLLVNLKDPSRPICKVGDFGLSKIKRNTLVTGGVRGTLPWMAPELLNgGSSKVSEKVDVFSFGIVLWEILTGEEPYANMHYGAIIGGIVSNTLRPHVPSSCDPEWRLLMEQCWAPDPMVRPSFAEIAR sGt+G+vy++kwrg+dvaikrlkks+f+ e+l+ ef++eaeilskL+hpnvva+yGvv+dgpgg+latvte+++ngslr+vl k+r+ldrrkr++ia+daa+GmeYLhs+++vhfdLk+dnLLv+l++p+rpickv+DfGLskikr+tlv+ggvrGtLPwmapell+ s++vsekvDv+sfGivlWe+ltgeePya++++gai++giv+++lrp+vP+scdpeWr Lme+Cwap+p rPsf+e+a+ sGtfGevylakwrgtdvaikrlkkslfa......eklvseflseaeilskLrhpnvvalyGvvkdgpggslatvteflrngslrsvlskkdrkldrrkrilialdaalGmeYLhskavvhfdLktdnLLvdlrepqrpickvaDfGLskikretlvsggvrGtLPwmapellr.sskevsekvDvysfGivlWelltgeePyaslnlgaillgivkeelrpavPescdpeWreLmeaCwapepaarPsftevae 432.8 3.5e-132 TKL-Pl-6 336 Cluster-5071.0-0R PF07714.14 1 256 9 260 SGTYGTVYHGKWR------GSDVAIKRLKKscftgRSSEQErlAVEFWREAEILSKLHHPNVVAFYGVVQdgPGGTLATVTEYMVNGSLRHVLISK--ERHLDRRKRLIIAMDAAFGMEYLHSRNIVHFDLKCDNLLVNLkdpsRPICKVGDFGLSKIK---RNTLVTGGVRGTLPWMAPELLNGGSskVSEKVDVFSFGIVLWEILT-GEEPYANMHYGAIIGGIvSNTLRPHVPSSCDPEWRLLMEQCWAPDPMVRPSFAEIARRL +G++G+V++g+++ +va+K lk+ +++e+e ef +ea+i++kl+hpn+v+++gv+ +++l vtey+ +G+L++ L +k +++l+ ++ l +a++ A GmeyL+s+++vH dl + N L++ + ++k++DfGL++ ++ ++++ + + WmapE l+ ++ +++k Dv+sfG++lwEi+t geepy++++ ++ + ++ r + p++c +e+ lm+qCw+ dp Rp+f+e+ ++l eGafGeVvegtlkgekekkevkvavKtlke.....eateee..keefleeakimkklkhpnivkllgvct..keepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlse....nkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekk..ftsksDvWsfGvllwEiftlgeepypglsneevlekl.kegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 202.6 4.2e-62 Protein tyrosine kinase 336 Cluster-5071.0-0R PF00069.22 1 253 9 259 SGTYGTVYHGK--WRGSDVAIKRLKKSCFTGRSSeqerlaVEFWREAEILSKLHHPNVVAFYGVVQDgpGGTLATVTEYMVNGSLRHVLIsKERHLDRRKRLIIAMDAAFGMEYLHSRNIVHFDLKCDNLLVNlKDPSrpiCKVGDFGLSKIKRNTLVTGGVRGTLPWMAPELLngGSSKVSEKVDVFSFGIVLWEILTGEEPYA----NMHYGAIIGG------IV-SNTLRPHVPSSCDPEWRLLMEQCWAPDPMVRPSFAEIA +G++G+Vy ++ ++g vA+K++kk+ + ++ +++rE +il kl+hpn+v +y+v+++ +l v+ey+ +g+l ++l ++ +l+ ++ ia + g+eylHs++i+H DlK +N+L++ ++ K++DFGl+k +++ + + gt ++APE+l +++++s+kvDv+s G++l+e+ltg++p++ + ++ +++ i+ +++ +++s++++e + l++++++ dp+ R++++e+ eGsfGkVykaveketgkivAvKkikkekakkkke......kkvlrEikilkklkhpnivrlyevfee..kdelylvleyveggeladlls.rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLid.ekge...lKitDFGlakelessskltsfvgtreYlAPEvl..keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeell 162.8 6.3e-50 Protein kinase domain 336 Cluster-5095.1-1F RLK-Pelle_DLSV 1 127 138 266 KISDFGLAKLYNNKETHIST-RVAGTFGYLAPEYAMRGHLTEKADVFSFGIVALEIVCGRLNSDTSFKDDEMYLLEWAWNLHEKNQEMALVDKTLDE-VNEDEVKRIIGVALLCSQASPSLRPSMSRVV ki+DFGla+l+++++t++st rv+gt+gY+aPeya++g+l+ek+Dv+sfG++ leiv G+ ns+++ ++++++lle+aw+l+e+++ + lvdk+l e ++++ev+r+i +allc q++p+ rp+ms+vv kiaDFGlarlfeedqteastkrvvgtlgYmaPeyalegqlseksDvysfGvlvleivsGkknsslkeeeeaeelleeawklweeekllelvdkslkeeaekeevlrcieiallcvqekpekrptmsevv 146.9 5.3e-45 RLK-Pelle_DLSV 337 Cluster-5095.1-1F PF00069.22 1 127 138 259 KISDFGLAKLYNNKEThiSTRVAGTFGYLAPEYAMRGHLTEKADVFSFGIVALEIVCGRLNSDTSFKDD-----EMYLLEWAWNLHEKNQEMALVDKTldevnEDEVKRIIGVallCSQASPSLRPSMSRVV Ki+DFGlak ++++++ t + gt YlAPE + + ++k+Dv+s G++ +e+++g+ + +++ + l + ++ l+e++++++ ++ ++e+k+++ + + p+ R++++ ++ KitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeasel.....seeakdllkk...llkkdpkkRltaeell 48.7 4.1e-15 Protein kinase domain 337 Cluster-5095.1-1F PF07714.14 1 130 144 260 KISDFGLAKLY-NNKETHISTRVAGTFGYLAPEYAMRGHLTEKADVFSFGIVALEIVC-GRLNsdtsfkddemyllewAWNLHEKNQEMALVDKTLDEVNEDEVKRIIGVALLCSQASPSLRPSMSRVVSML kisDfGLa+ +++e++ +++ + ++apE +++++t+k+Dv+sfG++ Ei++ g+ ++l++++ +l +++ e +e+ +++ + C +++p+ Rp+++++v+ l kisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep...............ypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 47.5 9e-15 Protein tyrosine kinase 337 Cluster-5095.2-2R RLK-Pelle_DLSV 2 171 19 172 NEKVIAVKLLSVTSRQGKRQFVAEIAAISAVQHRNLVKLYGCCIEGEKRLLVYEHLENKSLDKVLFdnkrnkisgaeslcpdeADNRRLSLDWPTRFNICLGVARGLAYLHEESQPRIVHRDVKASNILLDSNLNPKISDFGLAKLYNDKETHIST-RVAGTLGYLAPEYA ++k +Avk ls +s+qgk++f e++ i+++qhrnlvkL+gcciege++llvye+lenksLdk+lf ++++ +ldW+trf+i+ g+arGl+YLhees+++i+hrD+KasNiLLd+++npki+DFGla+l+++++t++st rv+gtlgY+aPeya dgkevAvkrlskkskqgkeefknevvliaklqhrnlvkLlgcciegeekllvyeylenksLdkflf.................deekkkeldWktrfkiikgiarGllYLheesrlkiihrDlKasNiLLdkemnpkiaDFGlarlfeedqteastkrvvgtlgYmaPeya 234.1 1.3e-71 RLK-Pelle_DLSV 171 Cluster-5095.2-2R PF00069.22 2 169 23 167 NEKVIAVKLLSVTSRQGKR--QFVAEIAAISAVQHRNLVKLYGCCIEGEKRLLVYEHLENKSLDKVLFdnKRNKISGAeslcpdeadnrrlsldwpTRFNICLGVARGLAYLHEESqprIVHRDVKASNILLDSNLNPKISDFGLAKLYNDKEThiSTRVAGTLGYLAPE ++k +AvK +++ +++ k+ ++++Ei+ + ++h+n+v+ly+++ e ++++lv e++e+++l+++l ++ ++s + + +i+ +++gl+ylH+++ i+HrD+K +NiL+d++ + Ki+DFGlak ++ +++ t + gt YlAPE tgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls..rkgslsee..................eakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPE 108.5 2.3e-33 Protein kinase domain 171 Cluster-5095.2-2R PF07714.14 3 170 28 177 EKVIAVKLLSVTSRQG-KRQFVAEIAAISAVQHRNLVKLYGCCIEGEKRLLVYEHLENKSLDKVLFDNkrnkisgaeslcpdeadNRRLSLDWPTRFNICLGVARGLAYLHEESqprIVHRDVKASNILLDSNLNPKISDFGLAKLY-NDKETHISTRVAGTLGYLAPEY e +avK l+ ++++ k++f+ e++ +++++h+n+vkl+g+c+++e+ l+v e++e+ +L+k L ++ +++ +l+ + ++++l +A+G++yL++++ +vHrd+ a N+Ll++n kisDfGLa+ +d+e++ +++ + ++apE evkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk.................eekekltlkdllsfalqiAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEs 106.7 7.9e-33 Protein tyrosine kinase 171 Cluster-5127.0-1F CK1_CK1 185 420 1 236 FKLGRKIGSGSFGELYLGVNIQNGEEVGIKLESVKTKHPQLHYESKVYMLLQGGTGIPNLKWFGVENDYNIMVIDLLGPSLEDLFNYCNRKFSLKTVLMLADQLINRVEYMHSRGFLHRDIKPDNFLMGLGRKANRVYIIDYGLAKKYRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLRAGTKKQKYDKISEKKMLTPIEVLCKSY fklgrkigsgsfge+ylg+n+q+ eev+iklesvktkhpql+yesk+y++lqggtgipnlkwfgve+dyn++v+dllgpsledlfnyc+rkfslktvlmladqlinrvey+hs+gflhrdikpdnflmglgrkan+vyiid+glakkyrd +t+khipyrenknltgtaryasvnthlg+eqsrrddleslgyvl+yflrgslpwqgl+agtkkqky+kisekk+ t+ievlcksy fklgrkigsgsfgeiylgtnvqtneevaiklesvktkhpqllyesklyrilqggtgipnlkwfgvegdynvlvldllgpsledlfnycsrkfslktvlmladqlinrveyvhskgflhrdikpdnflmglgrkanqvyiidfglakkyrdaktkkhipyrenknltgtaryasvnthlgieqsrrddleslgyvllyflrgslpwqglkagtkkqkyekisekkvstsievlcksy 479.4 1.3e-146 CK1_CK1 723 Cluster-5127.0-1F PF00069.22 186 403 2 212 KLGRKIGSGSFGELYLGVNIQNGEEVGIKLESVKTKHP----QLHYESKVYMLLQgGTGIPNLKWFGVENDYNIMVIDLLGP-SLEDLFNyCNRKFSLKTVLMLADQLINRVEYMHSRGFLHRDIKPDNFLMGlgRK-AnrVYIIDYGLAKKYRDLQThkhipyreNKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLRA-GTKKQKYDK + +k+G+GsfG+ y +v+ ++g++v +K +++ + ++ E k+ l+ i +l+ + e+d+ ++v++++ +l+dl + + ++s +++ +a q+++ +ey+Hs+g++HrD+Kp+N+L+ +k + i+D+Glak+++ ++ ++ +gt +Y + + e s+ D+ slG +l+ +l g p++g + ++++++d+ ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklk.hpnivrlyevfeekdelylvleyveggeladlls.rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLid..ekge..lKitDFGlakelesssk........ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldq 89.0 2.1e-27 Protein kinase domain 723 Cluster-5127.0-1F PF07714.14 186 446 2 257 KLGRKIGSGSFGELYLGVNI----QNGEEVGIKLESVKTKHP---QLHYESKVYMLLqGGTGIPNLKWFGVENDYNIMVIDLLG-PSLEDLFNYC--NRKFSLKTVLMLADQLINRVEYMHSRGFLHRDIKPDNFLMGlgrKANRVYIIDYGLAKKYRDLQTHkhipyRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLR-GSLPWQGLragTKKQKYDKISEKKMLTPIevlcKSYPSEFISYFHYCRSLRFEDKPDYSYLK +lg+k+G+G+fGe + g ++ +v +K + ++++ ++ e k+ + l i +l + ++++ ++v++++ +L++ + ++k++lk++l +a q+ + +ey++s+ ++Hrd+ N L+ + + v i D+GLa++ ++ ++ +++++ + ++ ++ + + + + D s G +l+ + g+ p++gl ++++ ++k++e+k l+ ++ p+e+ + + C + + e+ p+++ l elgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkkl.khpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLls...enkvvkisDfGLardiekddey.....kkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypgl...sneevleklkegkrlekp....ekcpeelyelmkqCweedpeeRptfkelv 47.1 1.2e-14 Protein tyrosine kinase 723 Cluster-5178.1-0F CAMK_OST1L 1 135 124 264 LENTLLDGSLAPRLKICDFGYSKSSLLHSQPKSTVGTPAYIAPEVLLR---KEYDGKIADVWSCGVTLYVMLVGAYPFEDPQEP---KDFRKTIQRILNVQYSIPDHVQISEECRHLISRIFVADPAQRITIPEIRDHVWF len+lLdgs ap+lkicDFg+skssl +s+pks+vGtpayiaPevl + keYdgk+aDvwscGv+Lyvml+gayPfed++++ k+++kt+qril+v+y+ip++v+iseecr+L+s+i+vadpa+Riti ei++h Wf lenllLdgseapllkicDFgfskssledskpksrvGtpayiaPevlaaakakeYdgkkaDvwscGvvLyvmllgayPfedeedkkekkevkktlqrileveykipevvaiseecrdLlskilvadpakRitieeikehpWf 204.4 1.5e-62 CAMK_OST1L 330 Cluster-5178.1-0F PF00069.22 2 135 127 264 ENTLLDGSLAprLKICDFGYSKSSLLHSQPKSTVGTPAYIAPEVLLRKEYdGKIADVWSCGVTLYVMLVGAYPFEDPQEPK----DFRK--TIQRIL-NVQYSIPDHVQISEECRHLISRIFVADPAQRITIPEIRDHVWF eN L+d + lKi+DFG +k +s+ +s vgt+ Y+APEvl ++ey +k +DvWs+Gv+ly +l g pf++ ++ + ++++ +i++il +++ ++p ++see+++l+++++ dp +R+t+ e+ +h ++ eNiLidekge..lKitDFGlakelessskltsfvgtreYlAPEvlkeney.skkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 103.8 6.4e-32 Protein kinase domain 330 Cluster-5178.1-0F PF07714.14 12 131 141 258 PRLKICDFGYSKSS---LLHSQPKSTVGTPAYIAPEVLLRKEYDGKiADVWSCGVTLYVMLV-GAYPFEDPqEPKDFRKTIqrilNVQYSIPDHVQISEECRHLISRIFVADPAQRITIPEIRD ki+DfG +++ ++ +++ ++apE+l +k++ k +DvWs Gv+l+ ++ g+ p+++ +++++ +++ + ++ ++ +++ee +l+++ + +dp++R t+ e+++ kvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsk.sDvWsfGvllwEiftlgeepypgl.sneevlekl....kegkrlekpekcpeelyelmkqCweedpeeRptfkelve 41.5 6.3e-13 Protein tyrosine kinase 330 Cluster-5209.0-2F STE_STE20-Pl 23 100 178 255 QVDVWALGVSAIEMAEGLPPRATVHPMRVLFMISSEPAPMLEDKEKWSLVFHDFVAKCLTKEPRLRPTAAEMLTHKFI +vdvwalgvsaiemaeglppr +vhp+rvlfmis+epapmledkekwslvfhdfvak+ltk+prlrp+a+e+l hkfi kvdvwalgvsaiemaeglpprsnvhplrvlfmisrepapmledkekwslvfhdfvakaltkdprlrpaasellkhkfi 150.1 4.5e-46 STE_STE20-Pl 183 Cluster-5209.0-2F PF00069.22 22 100 176 264 PQVDVWALGVSAIEMAEGLPPRA----------TVHPMRVLFMISSEPAPMLEDKEKWSLVFHDFVAKCLTKEPRLRPTAAEMLTHKFI ++vDvW+lGv +e+ g pp + ++ + +++i e l+ +++ s + d++ k+l+k+p+ R+ta+e+l h+++ kkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 37.7 9.5e-12 Protein kinase domain 183 Cluster-5209.0-2F PF07714.14 23 95 186 257 QVDVWALGVSAIEMAE-GLPPRATVHPMRVLFMISSEPApmLEDKEKWSLVFHDFVAKCLTKEPRLRPTAAEML + DvW+ Gv +E+++ g p +++++++vl +++++ le +ek++ +++++ +C++++p+ Rpt +e++ ksDvWsfGvllwEiftlgeepypglsneevleklkegkr..lekpekcpeelyelmkqCweedpeeRptfkelv 24.8 7.6e-08 Protein tyrosine kinase 183 Cluster-5304.0-0F AGC_NDR 1 192 111 257 AIQSIHQHSYVHRDIKPDNLILDKNGHLKLSDFGLCKPLDNKysslledddftaeasktdgegdgsasvpwlmakeqlqqwkrnrraLAYSTVGTLDYMAPEVLLKKGYGMECDWWSLGAIMYEMLVGYPPFCSDDPRMTCRKIINWKTCLKFPEEPKISVEAKDLICHLLCDVDRRLGTRGVDEIKAHPWF ai+sih+h+y+hrdikpdnl+ldk+ghlklsdfglckpld k laystvgt dy+apevllkkgygmecdwwslgai+yemlvgyppf+sddp tcrki+nw+t+lkfp+e k+s eakdli++llcdv++rlgt+g++eikahpwf aiesihkhnyihrdikpdnllldkeghlklsdfglckpldak.............................................laystvgtpdyiapevllkkgygmecdwwslgailyemlvgyppfysddplttcrkivnwrtllkfpdeaklskeakdlisrllcdvekrlgtkgaeeikahpwf 285.6 2.2e-87 AGC_NDR 372 Cluster-5304.0-0F PF00069.22 1 192 110 264 AIQSIHQHSYVHRDIKPDNLILDKNGHLKLSDFGLCKPLDNKYSslledddftaeasktdgegdgsasvpwlmakeqlqqwkrnrralAYSTVGTLDYMAPEVLLKKGYGMECDWWSLGAIMYEMLVGYPPFCSDDPRM----TCRK------IINwKTCLKFPEEPKISVEAKDLICHLLC-DVDRRLGtrgVDEIKAHPWF +++ +H+++ +HrD+Kp+N+++d++g+lK++DFGl+k l+++ + + s vgt +Y+APEvl +++y+ ++D+WslG i+ye+l g ppf +++ + +++ i++ +t +k+pe+ ++s eakdl+ ll+ d +Rl+ ++e+++hp++ gleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk............................................ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.etkeklpeaselseeakdllkkllkkdpkkRlt...aeellqhpyl 118.5 2.1e-36 Protein kinase domain 372 Cluster-5304.0-0F PF07714.14 3 43 118 160 QSIHQHSYVHRDIKPDNLILDKNGHLKLSDFGLCKPLDN--KY + ++++++vHrd+ N +l++n + k+sDfGL++ + + +y eyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddey 27.9 8.7e-09 Protein tyrosine kinase 372 Cluster-5304.0-0F PF07714.14 92 155 166 229 TVGTLDYMAPEVLLKKGYGMECDWWSLGAIMYEMLV-GYPPFCSDDPRMTCRKIiNWKTCLKFPE + + +mapE+l +k + + D Ws G +++E++ g p+ + +++ +++k+ + ++ l+ pe aklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevlekl.kegkrlekpe 23.9 1.4e-07 Protein tyrosine kinase 372 Cluster-531.0-1F STE_STE11 1 108 3 107 GRLLGRGSFGHVYLGFSSENGQMCAIKEVKVVSDDPsskeslkQLNQEITLLSQLAHMNIVQYYGSDLNEE---TLSVYLEYVSGGSIHKLLQE-HGPFREPVIQNYTRQIL g+llG+g+fg+Vyl++++e+g+++a+k+v++ s++ +L++Ei lls+L h niv+y+gs+++ee +l+++lEyvsggs+++ll++ g ++e+++++ytrqil gellGegafgsVylalnkesgellavksvelesaks.......aLekEikllskLkhpnivrylgseveeekseelnillEyvsggslasllkrlggklseslvrkytrqil 104.4 6.1e-32 STE_STE11 108 Cluster-531.0-1F PF00069.22 2 108 5 108 RLLGRGSFGHVYLGFSSENGQMCAIKEVKVVSDDPSSKeslKQLNQEITLLSQLAHMNIVQYYGSDLNEETLSVYLEYVSGGSIHKLLQEHGPFREPVIQNYTRQIL + lG+GsfG Vy ++++e+g++ A+K++k+ +++ +++ k++ +Ei++l +l h+niv++y++ ++++l + leyv+gg++++ll+++g + e ++++++qil eklGeGsfGkVykaveketgkivAvKkikkekakkkke...kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqil 79.0 2.4e-24 Protein kinase domain 108 Cluster-531.0-1F PF07714.14 2 92 5 95 RLLGRGSFGHVYLGFSS-ENGQMCAIKEVKVVSDdPSSKESLKQLNQEITLLSQLAHMNIVQYYGSDLNEETLSVYLEYVSGGSIHKLLQEH + lG+G+fG+V+ g + e+ + + vK++++ +++e+ +++ +e++++++l h niv+++g ++ee+l + +eyv+gG+++k L+++ kklGeGafGeVvegtlkgekekkevkvavKtlke.eateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk 52.2 3.3e-16 Protein tyrosine kinase 108 Cluster-5310.0-1F CK1_CK1 185 420 1 236 FKLGRKIGSGSFGELYLGVNIQNGEEVGIKLESVKTKHPQLHYESKVYMLLQGGTGIPNLKWFGVENDYNIMVIDLLGPSLEDLFNYCNRKFSLKTVLMLADQLINRVEYMHSRGFLHRDIKPDNFLMGLGRKANRVYIIDYGLAKKYRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLRAGTKKQKYDKISEKKMLTPIEVLCKSY fklgrkigsgsfge+ylg+n+q+ eev+iklesvktkhpql+yesk+y++lqggtgipnlkwfgve+dyn++v+dllgpsledlfnyc+rkfslktvlmladqlinrvey+hs+gflhrdikpdnflmglgrkan+vyiid+glakkyrd +t+khipyrenknltgtaryasvnthlg+eqsrrddleslgyvl+yflrgslpwqgl+agtkkqky+kisekk+ t+ievlcksy fklgrkigsgsfgeiylgtnvqtneevaiklesvktkhpqllyesklyrilqggtgipnlkwfgvegdynvlvldllgpsledlfnycsrkfslktvlmladqlinrveyvhskgflhrdikpdnflmglgrkanqvyiidfglakkyrdaktkkhipyrenknltgtaryasvnthlgieqsrrddleslgyvllyflrgslpwqglkagtkkqkyekisekkvstsievlcksy 479.4 1.3e-146 CK1_CK1 713 Cluster-5310.0-1F PF00069.22 186 403 2 212 KLGRKIGSGSFGELYLGVNIQNGEEVGIKLESVKTKHP----QLHYESKVYMLLQgGTGIPNLKWFGVENDYNIMVIDLLGP-SLEDLFNyCNRKFSLKTVLMLADQLINRVEYMHSRGFLHRDIKPDNFLMGlgRK-AnrVYIIDYGLAKKYRDLQThkhipyreNKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLRA-GTKKQKYDK + +k+G+GsfG+ y +v+ ++g++v +K +++ + ++ E k+ l+ i +l+ + e+d+ ++v++++ +l+dl + + ++s +++ +a q+++ +ey+Hs+g++HrD+Kp+N+L+ +k + i+D+Glak+++ ++ ++ +gt +Y + + e s+ D+ slG +l+ +l g p++g + ++++++d+ ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklk.hpnivrlyevfeekdelylvleyveggeladlls.rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLid..ekge..lKitDFGlakelesssk........ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldq 89.0 2.1e-27 Protein kinase domain 713 Cluster-5310.0-1F PF07714.14 186 446 2 257 KLGRKIGSGSFGELYLGVNI----QNGEEVGIKLESVKTKHP---QLHYESKVYMLLqGGTGIPNLKWFGVENDYNIMVIDLLG-PSLEDLFNYC--NRKFSLKTVLMLADQLINRVEYMHSRGFLHRDIKPDNFLMGlgrKANRVYIIDYGLAKKYRDLQTHkhipyRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLR-GSLPWQGLragTKKQKYDKISEKKMLTPIevlcKSYPSEFISYFHYCRSLRFEDKPDYSYLK +lg+k+G+G+fGe + g ++ +v +K + ++++ ++ e k+ + l i +l + ++++ ++v++++ +L++ + ++k++lk++l +a q+ + +ey++s+ ++Hrd+ N L+ + + v i D+GLa++ ++ ++ +++++ + ++ ++ + + + + D s G +l+ + g+ p++gl ++++ ++k++e+k l+ ++ p+e+ + + C + + e+ p+++ l elgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkkl.khpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLls...enkvvkisDfGLardiekddey.....kkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypgl...sneevleklkegkrlekp....ekcpeelyelmkqCweedpeeRptfkelv 47.1 1.2e-14 Protein tyrosine kinase 713 Cluster-5312.0-2F WNK_NRBP 1 142 23 165 EVAWNQVSIDDVLQSPEHLERLYSEVHLLRTLKHENIIRSYASWVDDENKTINMITELFTSGSLRQYRKKHKNVDLKAIKNWARQILRGLHYLHTHNPPIIHRDLKCDNIFVNGNHGEVKIGDLGLATIMQQ-PTARSVIGTP evaWnqv+i+dvl+spe+lerlysev+ll++lkh+nii+ yasWvd+++kt+n+itelftsG+Lrqyrkkhk+vdlka+k+warqil+gL+yLh+++PpiihrdlkCdnifvnGn+GevkigdlGla+++++ +a+sv+Gtp evaWnqvkiedvlrspeelerlysevrllkelkhkniiklyasWvdekkktvnlitelftsGtLrqyrkkhkkvdlkavkkwarqilkgLeyLhskdPpiihrdlkCdnifvnGnsGevkigdlGlaavlreakaaksvlGtp 251.3 8.3e-77 WNK_NRBP 142 Cluster-5312.0-2F PF00069.22 16 142 39 161 PEHLERLYSEVHLLRTLKHENIIRSYASWVDdeNKTINMITELFTSGSLRQYRKKHKNVDLKAIKNWARQILRGLHYLHTHNppIIHRDLKCDNIFVNgNHGEVKIGDLGLATIMQQPT-ARSVIGTP ++ +++ +E+++l++lkh+ni+r y ++ + ++++ +++e+ g+l ++ +++++++ + +k++a+qil+gl+ylH ++ iiHrDlK +Ni+++ ++ge+Ki+D+Gla+ +++ + ++s++gt+ kkkekkvlrEikilkklkhpnivrlyevfee..kdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskg..iiHrDlKpeNiLid.ekgelKitDFGlakelessskltsfvgtr 109.7 1e-33 Protein kinase domain 142 Cluster-5312.0-2F PF07714.14 16 131 42 155 PEHLERLYSEVHLLRTLKHENIIRSYASWVddENKTINMITELFTSGSLRQYRKKH---KNVDLKAIKNWARQILRGLHYLHTHNppIIHRDLKCDNIFVNGNHgEVKIGDLGLATIMQ e+ e++ +e++++++lkh+ni++ ++ + +++++ ++te+ ++G+L+++ +k+ ++++lk + ++a+qi +G++yL+ ++ ++Hrdl + N++++ n+ vki+D GLa ++ eeekeefleeakimkklkhpnivkllgvct..keepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskk..lvHrdlaarNvLlsenk.vvkisDfGLardie 81.1 5.1e-25 Protein tyrosine kinase 142 Cluster-5331.0-2R RLK-Pelle_LRR-II 1 150 118 268 DPKIIHRDVKAANILLDEDFEAVVGDFGMAKLLDHRDSHVTTAVRGTIGHIAPEYLSTGQSSERTDVFGFGILLLELITGHKAVDFGRGAHQKGVML-DWVKKLHQEGKLNLMVDKDLKNNFDRVELEEMVRVALLSTEFNPSQRPKMSEA dpkiihrdvkaanillde+feavvgdfg+aklld++dshvttavrGt+GhiapeylstG+sse+tdvfG+GilllelitG++a++++r a++++v+l dwvkkl++e kl+ +vdkdlk+++d++e+ee+v+vall t+++p++rpkmse dpkiihrdvkaanilldeefeavvgdfglaklldkkdshvttavrGtvGhiapeylstGkssektdvfGyGilllelitGqralelsrlaededvllldwvkklkkekkleklvdkdlkkeydeaeveelvqvallctqvspeerpkmsev 259.8 1.9e-79 RLK-Pelle_LRR-II 157 Cluster-5331.0-2R PF00069.22 3 152 118 260 KIIHRDVKAANILLDEDFEAVVGDFGMAKLLDHRDShvTTAVRGTIGHIAPEYLSTGQSSERTDVFGFGILLLELITGHKAVDFGRGAHQKGVMLDWVK---KLHQEGKLNLMVDKDLknnfdrveLEEMVRVALLSTEFNPSQRPKMSEALR +iiHrD+K +NiL+de+ e ++DFG+ak l+++ + +t + gt +APE l++ + s+ +Dv++ G++l+el+tg+ +g +++ +ld ++ k+ +e k++l ++++l ee+ ++ + +p++R+ ++e+l+ giiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeasel........seeakdllkkllkkdpkkRltaeellq 76.3 1.5e-23 Protein kinase domain 157 Cluster-5331.0-2R PF07714.14 3 152 124 258 KIIHRDVKAANILLDEDFEAVVGDFGMAKLL-DHRDSHVTTAVRGTIGHIAPEYLSTGQSSERTDVFGFGILLLELIT-GHKAvdfgrgahqkgvmldwVKKLHQEGKLNLMvDKDLKNNFDRVELEEMVRVALLSTEFNPSQRPKMSEALR k++Hrd+ a N+Ll+e+ + ++DfG+a+ + ++ + ++++ + + +apE l++++ ++++Dv+ fG+ll E++t g++ +++l++e l+ + +++ + + + ee+ ++ + e +p++Rp+++e ++ klvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep................ypglsneevlekl.kegkrlekpekcpeelyelmkqCweedpeeRptfkelve 70.3 1e-21 Protein tyrosine kinase 157 Cluster-5366.0-0F RLK-Pelle_DLSV 228 413 81 266 QFCVDEDKKTILPWPKRYDIIMGIAKGLLYLHHDSRLNVIHRDLKTSNILLDEHLNPKISDFGLARIVGGDQSMGRTRRVIGTYGYMAPEYTIDGKFSIKSDVFSMGVVLLEIVSGKRNREFRHKDHCHCLLGHAWLLWKEDRALELMDKCLKDRDVEYQVKRCIHVGLLCVQKRAEDRPNMSSVV +f +de+kk+ l W++r++ii gia+GllYLh++srl++ihrDlK+sNiLLd+++npki+DFGlar+++ dq+ t+rv+gt+gYmaPey+++g++s ksDv+s Gv++leivsGk+n++++++++ + ll +aw lw+e+++lel+dk lk++ + +v+rci+++llcvq+++e+rp+ms+vv kflfdeekkkeldWktrfkiikgiarGllYLheesrlkiihrDlKasNiLLdkemnpkiaDFGlarlfeedqteastkrvvgtlgYmaPeyalegqlseksDvysfGvlvleivsGkknsslkeeeeaeelleeawklweeekllelvdkslkeeaekeevlrcieiallcvqekpekrptmsevv 252.7 2.8e-77 RLK-Pelle_DLSV 440 Cluster-5366.0-0F PF00069.22 243 410 99 256 KRYDIIMGIAKGLLYLHHDSrlnVIHRDLKTSNILLDEHLNPKISDFGLARIVGGDQSmgrTRRVIGTYGYMAPEYTIDGKFSIKSDVFSMGVVLLEIVSGKRNREFRHKD-----HCHCLLGHAWLLWKEDRALELMDKClkdrdveyqVKRCIHVGLLCVQKRAEDRPNMS + +i+ i++gl ylH+ + +iHrDlK++NiL+de+ + Ki+DFGla+ + +++ ++ ++gt Y+APE + ++s k+Dv+s+Gv+l+e+++gk + ++++ +++ l +++l +++ +l+ +++ + ++++ +++k ++R+ ++ eakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeasel.........seeakdllkkllkkdpkkRltae 97.6 5e-30 Protein kinase domain 440 Cluster-5366.0-0F PF07714.14 234 413 96 257 DKKTILPWPKRYDIIMGIAKGLLYLHHDsrlNVIHRDLKTSNILLDEHLNPKISDFGLARIVGGDQSMGRTRRVIGTYGYMAPEYTIDGKFSIKSDVFSMGVVLLEIVS-GKRNrefrhkdhchcllghaWLLWKEDRALELMDKCLKDRDVEYQVKRCIHVGLLCVQKRAEDRPNMSSVV ++k+ l + +++++ iAkG+ yL++ +++Hrdl + N+Ll+e+ kisDfGLar + d+++ ++++ + +mapE ++kf++ksDv+s Gv+l Ei++ g++ + +++ ++le +++ + + e+ ++ ++ C+++++e+Rp+++++v eekekltlkdllsfalqiAkGmeyLesk...klvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep................ypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelv 91.4 3.7e-28 Protein tyrosine kinase 440 Cluster-5366.0-2F RLK-Pelle_DLSV 99 184 2 87 NMIGEGGYGPVYRGSLSDGQRIAVKRLSKTSTQGLEEFTNEVSLIAKLQHRSLVRLLGCCSTGEERMLIYEYMQNRSLNTFIFGAT n++GeGg+g vY+g l+dg+++Avkrlsk+s+qg eef+nev+liaklqhr lv+Llgcc +gee++l+yey++n+sL++f+f ++ nklGeGgfgkvYkgkledgkevAvkrlskkskqgkeefknevvliaklqhrnlvkLlgcciegeekllvyeylenksLdkflfdee 123.7 6.1e-38 RLK-Pelle_DLSV 439 Cluster-5366.0-2F PF07714.14 99 180 5 92 NMIGEGGYGPVYRGSLS-----DGQRIAVKRLSKTSTQG-LEEFTNEVSLIAKLQHRSLVRLLGCCSTGEERMLIYEYMQNRSLNTFI + +GeG +G V++g+l+ + +++avK l++++t+ eef++e++++ kl+h+ +v+llg+c+ +e+ +++ ey+++ +L++f+ kklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfL 56.1 2.1e-17 Protein tyrosine kinase 439 Cluster-5366.0-2F PF00069.22 98 180 4 89 VNMIGEGGYGPVYRGS-LSDGQRIAVKRLSKTSTQGLEE--FTNEVSLIAKLQHRSLVRLLGCCSTGEERMLIYEYMQNRSLNTFI ++ +GeG++G Vy++ ++g+ +AvK+++k +++ +e +++E+++++kl+h+ +vrl++++++ +e++l+ ey+++ +l++++ leklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladll 51.6 5.3e-16 Protein kinase domain 439 Cluster-5416.1-1F CK1_CK1 43 278 1 236 FKLGRKIGSGSFGEIFLATHIDTFEIVAVKIENNKTKHPQLFYEAKIYNVLQGGSGIPGIKWSGVDGEDNILVLDLLGPSLEDLFVYCGRKFSLKTVLMLADQMITRIEFVHSKGFLHRDIKPDNFLMGLGRKANQVYIIDFGLAKRYRDSTTNRHIPYRENKNLTGTARYASCNTHLGIEQSRRDDLESLGYVLLYFLRGSLPWQGLKAATKKQKYDKICEKKLSTPIEVLCKSH fklgrkigsgsfgei+l+t+++t e va+k+e+ ktkhpql ye+k+y++lqgg+gip +kw gv+g+ n+lvldllgpsledlf yc+rkfslktvlmladq+i+r+e+vhskgflhrdikpdnflmglgrkanqvyiidfglak+yrd++t++hipyrenknltgtaryas+nthlgieqsrrddleslgyvllyflrgslpwqglka+tkkqky+ki+ekk+st+ievlcks+ fklgrkigsgsfgeiylgtnvqtneevaiklesvktkhpqllyesklyrilqggtgipnlkwfgvegdynvlvldllgpsledlfnycsrkfslktvlmladqlinrveyvhskgflhrdikpdnflmglgrkanqvyiidfglakkyrdaktkkhipyrenknltgtaryasvnthlgieqsrrddleslgyvllyflrgslpwqglkagtkkqkyekisekkvstsievlcksy 463.5 9.4e-142 CK1_CK1 282 Cluster-5416.1-1F PF00069.22 44 261 2 212 KLGRKIGSGSFGEIFLATHIDTFEIVAVKIENNKTKHP----QLFYEAKIYNVLQgGSGIPGIKWSGVDGEDNILVLDLLG-PSLEDLFVyCGRKFSLKTVLMLADQMITRIEFVHSKGFLHRDIKPDNFLMGlgrKANQVYIIDFGLAKRYRDSTTnrhipyreNKNLTGTARYASCNTHLGIEQSRRDDLESLGYVLLYFLRGSLPWQGLKAAT-KKQKYDK + +k+G+GsfG+++ a++ +t +ivAvK+ +++ + +++ E ki + l+ + i ++ + + ++ +lvl+++ +l+dl ++s +++ +a q+++ +e++Hskg++HrD+Kp+N+L+ + +++ i+DFGlak+++ s++ ++ +gt +Y + + e s+ D+ slG +l+ +l g p++g k + +++++d+ ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklk.hpnivrlyevfeekdelylvleyveggeladlls.rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLid...ekgelKitDFGlakelesssk........ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldq 96.3 1.2e-29 Protein kinase domain 282 Cluster-5416.1-1F PF07714.14 44 255 2 215 KLGRKIGSGSFGEIFLATHI----DTFEIVAVKIENNKTKHP---QLFYEAKIYNVLqGGSGIPGIKWSGVDGEDNILVLDLLG-PSLEDLFVYC--GRKFSLKTVLMLADQMITRIEFVHSKGFLHRDIKPDNFLMGlgrKANQVYIIDFGLAKRYRDSTTNrhipyRENKNLTGTARYASCNTHLGIEQSRRDDLESLGYVLLYFLR-GSLPWQGLKAATK +lg+k+G+G+fGe++ +t ++ vavK+ ++++++ +++ eaki + l i + +++e ++v++++ +L++ +k++lk++l +a q+ +e+ +sk ++Hrd+ N L+ + ++v i DfGLa++ +++ + +++++ + ++ + + + + + D s G +l + g+ p++gl++++ elgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkkl.khpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLls...enkvvkisDfGLardiekddey.....kkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneev 50.0 1.5e-15 Protein tyrosine kinase 282 Cluster-5431.0-1F RLK-Pelle_LRR-I-2 177 425 1 249 FTTLIGQGAFGLVYKAQMSTGETVAVKVLATDSKQGEKEFQTEVMLLGRLHHRNLVNLVGYCAEKNQNMLIYVYMSRGSLASHLYNEKLDPLKWELRVQIALDIARGLEYLHDGAVPPVIHRDIKSSNILLDESMRARVADFGLSREEMVDKHVSNIRGTFGYLDPEYISTRSFTKKSDVYSYGVLLFELIAGRNPLQGLMDYVELAAMNTEGKVGWEELVDPHLDGKFDIEELNEVAALAYKCVNRTP fttl+GqGafG vyka++stGe++avkvla+dskqG+kefqtev+llgrlhhrnlvnlvGyc+ek+q++l+y+yms+Gsl+s+ly+e+ ++l+w+ rv+iald++rGleylh+Gavppv+hrdiks+nilld+smrarvadfGls+ee+vdk+vs+++GtfGyldpeyist+sftkksdvys+Gvllfeli++rnp qgl++yvelaa+++e+k++wee++d +l+g++d+ee++e+aa+aykcv+++p fttllGqGafGpvykavlstGevlavkvlaedskqGdkefqtevlllgrlhhrnlvnlvGyceekgqrilvyeymsnGslesklydenkeslswdervlialdvsrGleylheGavppvvhrdiksanilldasmrarvadfGlskeevvdkivsgvkGtfGyldpeyistnsftkksdvysfGvllfelitarnpqqglleyvelaalgaeekedweeildsrlegnadleevrelaaiaykcvskvp 466.9 1.2e-142 RLK-Pelle_LRR-I-2 425 Cluster-5431.0-1F PF07714.14 177 385 3 219 FTTLIGQGAFGLVYKAQMS-----TGETVAVKVLATDSKQG-EKEFQTEVMLLGRLHHRNLVNLVGYCAEKNQNMLIYVYMSRGSLASHLYNE-KLDPLKWELRVQIALDIARGLEYLHDGAvppVIHRDIKSSNILLDESMRARVADFGLSREEMVDKHV---SNIRGTFGYLDPEYISTRSFTKKSDVYSYGVLLFELIA-GRNPLQGLMDYVELAAM +++ +G+GafG V++++++ + +vavK+l ++++ ++ef +e+ ++ +l+h+n+v+l+g c ++++ +++ y++ G+L ++L ++ + ++l+ + +++al+iA+G+eyL++ ++Hrd+ + N+Ll+e++ ++++DfGL+r+ + d++ ++ + + ++ pE +++++ft+ksDv+s+Gvll+E++ g++p++gl++ l+++ lgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevlekl 170.3 3.1e-52 Protein tyrosine kinase 425 Cluster-5431.0-1F PF00069.22 175 376 1 200 YNFTTLIGQGAFGLVYKAQ-MSTGETVAVKVLATDSKQGEKE--FQTEVMLLGRLHHRNLVNLVGYCAEKNQNMLIYVYMSRGSLASHLYNEKLdpLKWELRVQIALDIARGLEYLHDGAvppVIHRDIKSSNILLDESMRARVADFGLSREEMVDKHVSNIRGTFGYLDPEYISTRSFTKKSDVYSYGVLLFELIAGRNPLQGL y+ + +G+G+fG Vyka +tg++vAvK++ +++++ +ke +++E+ +l +l+h+n+v+l++++ ek++ +l+ y++ g+la++l +++ l+ e +ia i++gleylH+ +iHrD+K++NiL+de+ +++DFGl++e +++++++ gt Yl PE +++++++kk+Dv+s+Gv+l+el++g++p++g yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgs..lseeeakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsge 165.5 9.6e-51 Protein kinase domain 425 Cluster-5444.0-1R CAMK_CDPK 1 173 88 259 LDRILSRgGKYTEDDAKSVIMQILNVVAFCHLQGVVHRDLKPENFLFTSKDENSQLKAIDFGLSDFVKPDERLNDIVGSAYYVAPEVLHRAYTTEADVWSIGVIAYILLCGSRPFWARTESGIFRAVVKAEPSYEEQPWPTLSSEAKDFVKRLLNKDPRKRMTAAQAMCHPWI ldril+r gky+e++a++v++qil+vva+cH +gvvhrDlKPeNfl+tsk+e+++lkaiDFGls+fvk++erl+divGs+yyvaPEvl+r y +eadvWs+Gvi+yillcg++pfwa+te++if+av+kae++++++pw+++s+eakd+v+rlL+kdp+kR+ta+q++ hpW+ ldrilar.gkyseraaakvvrqilevvaacHskgvvhrDlKPeNflltskeedaplkaiDFGlsvfvkegerledivGspyyvaPEvlkrsygkeadvWsaGvilyillcgvppfwaeteeeifkavlkaeldfksepwksvseeakdlvrrlLekdpkkRltaeqvLehpWl 274.7 6.3e-84 CAMK_CDPK 446 Cluster-5444.0-1R PF00069.22 1 173 85 264 LDRILSRGGKYTEDDAKSVIMQILNVVAFCHLQGVVHRDLKPENFLFTsKDENsqLKAIDFGLSDFVKPDERLNDIVGSAYYVAPEVL-HRAYTTEADVWSIGVIAYILLCGSRPFWARTESGIFRAVVKA---------EPSYEEQPWPTLSSEAKDFVKRLLNKDPRKRMTAAQAMCHPWI l+++lsr g+++e++ak+++ qil+ ++++H +g++HrDlKpeN+L++ ++++ lK +DFGl+ ++ +++l+++vg+ +Y+APEvl ++ y++++DvWs+Gvi y ll+g pf++++++ +++ ++ e + + + + +ls+eakd++k+ll+kdp+kR+ta++++ hp++ ladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLid.ekge..lKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 167.1 3.1e-51 Protein kinase domain 446 Cluster-5444.0-1R PF07714.14 9 166 99 255 GKYTEDDAKSVIMQILNVVAFCHLQGVVHRDLKPENFLFTSkdeNSQLKAIDFGLSDFVKPDERL---NDIVGSAYYVAPEVLH-RAYTTEADVWSIGVIAYILLC-GSRPFWARTESGIFRAVvKAEpsYEEQPWPTLSSEAKDFVKRLLNKDPRKRMTAAQ k t +d s+++qi + +++ + + +vHrdl N L ++ n++ k DfGL++ ++ d++ ++ + ++apE+l+ + +t+++DvWs Gv+ + +++ g++p++ +++ +++++ k++ ++ + + ++e ++++k+ +++dp++R t ++ ekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlse...nkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevlekl.keg..krlekpekcpeelyelmkqCweedpeeRptfke 58.7 3.5e-18 Protein tyrosine kinase 446 Cluster-5473.0-0F STE_STE7 141 398 2 261 HVSVIGKGNGGTVRLVQHKWTGQFFALKVIQMNIEESARKHIAQELKINQSSQCPYVVICYQSFYD-NGAVSIILEYMDGGSLADFLKKVQKIPEPCLAAICKQVLKGLWYLHHeKHVIHRDLKPSNLLINHTGEVKITDFGVSAILASTSGLANTFVGTYNYMSPERIR----GDNHGFRSDIWSLGLVILECATGRFPYTP-PHQGGWATfyeLMNTIVDQPAPRAPDDLFSPEFCSFISACVQKDPGARLSANELMAHPFI +v+v+GkG++g+V++v+h++t++++AlKvi++niee++rk+i++elki++++++p+vv c+++f++ +g++si+LeymdgGsLad+lkk++kipep la++++qvLkgl yLh+ ++++hrd+kPsnlLin++gevKI+DFgvs+ilas+ + +ntfvgt++YmsPeri+ g+++++ +DiWslGl++Le+a+GrfP++p ++ +wa+ Lm +iv++++p+ap+d fs+ef+sF+sac+qkd+ +R sa+eL++hpF+ kvkvlGkGasgvVykvrhretskiyAlKvikvnieeavrkqilrelkilreaespsvvkchgvfespsgeisivLeymdgGsLadvlkkkkkipepalaevarqvLkglayLhk.rkivhrdikPsnlLinskgevKIaDFgvskilasslaqcntfvgtvaYmsPerieseaagesysyaaDiWslGltlLelalGrfPllplgekedwaa...LmlaiveeeppeapadafseefrsFvsaclqkdaekRasaeeLlehpFv 374.6 2.2e-114 STE_STE7 542 Cluster-5473.0-0F PF00069.22 141 398 3 264 HVSVIGKGNGGTVRLVQHKWTGQFFALKVIQMNIEESAR-KHIAQELKINQSSQCPYVVICYQSFYDNGAVSIILEYMDGGSLADFLKKVQKIPEPCLAAICKQVLKGLWYLHhEKHVIHRDLKPSNLLINHTGEVKITDFGVSAILASTSGlANTFVGTYNYMSPERIRGDNHGFRSDIWSLGLVILECATGRFPYTPPHQ--GGWATFYE---LMNTIVDQPAPRAPDDLFSPEFCSFISACVQKDPGARLSANELMAHPFI ++ +G+G+ G+V + +k+tg+ +A+K+i+ + +++ + k++++E+ki +++++p++v +y++f+++ + ++ley++gg+lad+l++ ++++e + i+kq+l+gl ylH +k++iHrDlKp+N+Li+++ge+KitDFG+++ l s+s +++fvgt +Y++PE +++ +++ +D+WslG++++e tg+ p+ ++ ++ + + +++++ ++ + ++ +s+e+ ++++ +++kdp Rl+a+el++hp++ kleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylH.skgiiHrDlKpeNiLidekgelKitDFGlakelesssk.ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 226.0 3.3e-69 Protein kinase domain 542 Cluster-5473.0-0F PF07714.14 143 393 5 257 SVIGKGNGGTVRLVQHK----WTGQFFALKVIQMNIEESARKHIAQELKINQSSQCPYVVICYQSFYDNGAVSIILEYMDGGSLADFLKKV---QKIPEPCLAAICKQVLKGLWYLHhEKHVIHRDLKPSNLLINHTGEVKITDFGVSAIL--ASTSGLANTFVGTYNYMSPERIRGDNHGFRSDIWSLGLVILECAT-GRFPYTpphqgGWaTFYELMNTIVDQPAPRAPDDlFSPEFCSFISACVQKDPGARLSANELM + +G+G+ G+V + k + + a+K+++ + +e++++++ +e+ki ++ + p +v ++ ++++ + i++ey++gG+L +fL+k +k+ l +++q+ kG+ yL+ +k+++Hrdl N L++++ vki+DfG++ + ++ ++ +++m+pE ++ + +sD+Ws G ++ E +t g+ py+ g+ + e+++++ ++ ++p++ ++e+ ++++ C+++dp R + +el+ kklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLe.skklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepyp.....gl.sneevleklkegkrlekpek.cpeelyelmkqCweedpeeRptfkelv 123.9 4.6e-38 Protein tyrosine kinase 542 Cluster-5504.0-2R CK1_CK1-Pl 125 262 1 136 YRVDRKLGKGGFGQVYVGRRINPpnPSERTGPGAVEVALKFEHRSSKGCNYGPPYEWQVYVALGGSHGIPRVHYKGRQNDYYIMVMDMLGPSLWDVWNNNSHTMSIEMVACIAIEAISILEKLHSRGYVHGDVKPENF y+v+rklgkggfgqvyvgrr++ ++rtg+ a+evalkfehrsskgcnygppyewqvy +lgg++g+p+vhykgrq+dyyi+vmd+lgpslwdvwn++++++s emvacia+eaisileklh++gyvhgdvkpenf ykverklgkggfgqvyvgrrvss..akdrtgadalevalkfehrsskgcnygppyewqvyntlggvygvpkvhykgrqgdyyilvmdllgpslwdvwnssgqalseemvaciaveaisileklhakgyvhgdvkpenf 268.8 3.5e-82 CK1_CK1-Pl 262 Cluster-5504.0-2R PF00069.22 125 262 1 129 YRVDRKLGKGGFGQVYVGRRINppnpseRTGpgavEVALKFEHRSSKGCNY--GPPYEWQVYVALGgSHGIPRVHYKGRQNDYYIMVMDMLG-PSLWDVWNnNSHTMSIEMVACIAIEAISILEKLHSRGYVHGDVKPENF y++++klG+G+fG+Vy +++ + + +vA+K ++++ + E ++ l + i r+ + +++d++++v++++ +l+d+ + ++ ++s e + ia + ++ le lHs+g +H D+KpeN+ yekleklGeGsfGkVykaveke......tgk....ivAvKkikkekakkkkekkvlrEikilkklk.hpnivrlyevfeekdelylvleyveggeladlls.rkgslseeeakkiakqilegleylHskgiiHrDlKpeNi 32.5 3.5e-10 Protein kinase domain 262 Cluster-5517.0-2F PEK_GCN2 119 286 118 302 LPRSLETYLSEFKNSYSLKDAMQIFGQIVAGVAYIHGSGYIHQDLSPRNIFLDKDGIIKIGDFGLA-----EKLDEDGSVPLSALW---------PPIPYRAPEYKRGEP-VDAKADIFSLGLILAELLHPFEDETERSEGLKRVRKKFRLPRHWQV--VKFAGLCNLMISKYPFVRPTADEILE pr+l ++ +++s++ +da +++ qiv+G+a+ih+ G ih+dl p nif d + ikiGdfGla e+ld+d++++ +++ y ape +++ p +d k+d++slG++l el +pf er l+ +++k +lp +w++ + a l + +++ p rp+a e+l+ cprtlrevfesyegsldkedawrllrqiveGlahihsqGiihrdltpnniffdarndikiGdfGlakflkleqldkdtnlsaevagvslegtGqvGtyfytapeieqkwpkidekvdlyslGvvlfelwypfatameravilsdlkskGelplawatefpeqakllrrllapspsdrpsavellk 103.2 1.5e-31 PEK_GCN2 371 Cluster-5517.0-2F PF00069.22 122 286 84 260 SLETYLSeFKNSYSLKDAMQIFGQIVAGVAYIHGSGYIHQDLSPRNIFLDKDGIIKIGDFGLAEKLDEDGSvpLSALWPPIPYRAPEYKRGEPVDAKADIFSLGLILAELL---HPFEDETERSEGLKRVRK-----------KFRLPRHWQV-VKFAGLCNLMISKYPFVRPTADEILE +l+++ls k s+s ++a +i+ qi++g++y+H g iH Dl p Ni++d++g +Ki+DFGla++l+++ + l+ Y+APE +++++++k+D++slG+il+ell +pf++e+++++ k +++ k+ lp+ ++ ++ l++ +++k p R+ta+e+l+ eladlls.rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellq 94.6 4e-29 Protein kinase domain 371 Cluster-5517.0-2F PF07714.14 122 284 87 256 SLETYLSEF--KNSYSLKDAMQIFGQIVAGVAYIHGSGYIHQDLSPRNIFLDKDGIIKIGDFGLAEKL-DEDGSVPLSALWPPIPYRAPEYKRGEPVDAKADIFSLGLILAELLH----PFEDEtERSEGLKRVRKKFRLPRHWQVV-KFAGLCNLMISKYPFVRPTADEI +L+++L + k++ +lkd +++ qi +G++y++ ++H+dl+ rN++l+++ ++ki+DfGLa+++ ++d + + p+ + apE + + + k+D++s G +l E++ p+++ + +e l++++++ rl++ ++ +++ l + +++ p Rpt +e+ dLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypgl.sneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkel 79.6 1.5e-24 Protein tyrosine kinase 371 Cluster-5534.0-1R RLK-Pelle_RLCK-V 1 188 80 267 EQWLHGAMRHHGSLTWEARMKVLLGTAKALAYLHEAIEPKVVHRDIKSSNILIDDEFNAKVSDFGLAKLLGAGTSHITTRVMGTFGYVAPEYANTGLLNEKSDVYSFGVLLLEAITGRDPVDYGRPAQEVNLVDWLKMMVGSKRSEEVIDPYMDTRPSTRALKRALLTVLRCVDPDSNKRPRMTQVVQ eqwlhG+++++++ltwearmk++lgtakalaylhea+epkvvhrdikssnil+d+efnakvsdfGlakllg+++s++ttrvmgtfgyvapeyantgllneksdvysfgvllle+itgrdpvdy rpa+evnlv+wlk+mv+++r+eev+dp ++++ps+ralkrall+ lrcvdpd++krp+m+qvv+ eqwlhGdvseksaltwearmkiilgtakalaylhealepkvvhrdikssnilldkefnakvsdfGlakllgseksyvttrvmgtfgyvapeyantgllneksdvysfgvllleiitgrdpvdysrpaeevnlvewlklmvaerraeevvdpkleekpssralkrallvalrcvdpdaekrpkmgqvvk 359.6 6e-110 RLK-Pelle_RLCK-V 188 Cluster-5534.0-1R PF00069.22 4 188 85 260 LHGAMRHHGSLTWEARMKVLLGTAKALAYLHEAIepkVVHRDIKSSNILIDDEFNAKVSDFGLAKLLGAGTShiTTRVMGTFGYVAPEYANTGLLNEKSDVYSFGVLLLEAITGRDPVDYGRPAQ--EVNLVDwLKMMVGSKRseevidPYMDTRPSTRALKRALLT-VLRCVDPDSNKRPRMTQVVQ l+ +++++gsl+ e k++ ++++l+ylH++ ++HrD+K++NiLid++ + K++DFGlak l +++ +t ++gt Y+APE ++ +k+Dv+s Gv+l+e +tg+ p + + e +l + l++++ + ++ + p + l++ ++ + ++++ d +kR+ +++++q ladllsrkgslseeeakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldq.lekilkilg......etkeklpeaselseeakdllkkllkkdpkkRltaeellq 104.4 4.2e-32 Protein kinase domain 188 Cluster-5534.0-1R PF07714.14 10 187 94 257 H---HGSLTWEARMKVLLGTAKALAYLHEAiepKVVHRDIKSSNILIDDEFNAKVSDFGLAKLL-GAGTSHITTRVMGTFGYVAPEYANTGLLNEKSDVYSFGVLLLEAIT-GRDPvdygrpaqevnlvdwLKMMVGSKRSEEVIDPYMDTRPSTrALKRALLTVLRCVDPDSNKRPRMTQVV + + +lt + +++ l Ak+++yL++ k+vHrd+ + N+L++++ +k+sDfGLa+ + + + +++ + ++apE +++ +++ksDv+sfGvll E +t g++p ++ + ++ e + + + ++p++ + ++ + +C++ d+++Rp+++++v kkeekekltlkdllsfalqiAkGmeyLesk...klvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep...............ypglsneevleklkegkrlekpek.cpeelyelmkqCweedpeeRptfkelv 89.9 1.1e-27 Protein tyrosine kinase 188 Cluster-5610.0-2R CAMK_OST1L 2 220 40 264 DENVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYAAGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQICHRDLKLENTLLDGSQAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLK---KEYDGKIADVWSCGVTLYVMLVGAYPFEDPQEP---KNFRKTIQRILNVQYSIPDYVHISPECHHLISRIFVADPAKRITIPEIRNHEWF denvkrEi+nhrsLrHpnivrfkev+ltpthla+vmEYa+ggel+e+++++gr+sedear++fqQl+sgv+ycH++++++Rdlklen+lLdgs+ap+lkicDFg+skss+ +s+pks+vGtpayiaPevl + keYdgk+aDvwscGv+Lyvml+gayPfed++++ k+++kt+qril+v+y+ip++v+is+ec++L+s+i+vadpakRiti ei++h+Wf denvkrEilnhrsLrHpnivrfkevvltpthlalvmEYadggelleyvskkgrlsedearylfqQlvsgvdycHrkgvvnRdlklenllLdgseapllkicDFgfskssledskpksrvGtpayiaPevlaaakakeYdgkkaDvwscGvvLyvmllgayPfedeedkkekkevkktlqrileveykipevvaiseecrdLlskilvadpakRitieeikehpWf 376.8 3.9e-115 CAMK_OST1L 232 Cluster-5610.0-2R PF00069.22 3 220 43 264 ENVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYAAGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQICHRDLKLENTLLDGSQAprLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYdGKIADVWSCGVTLYVMLVGAYPFEDPQEPK----NFRK--TIQRIL-NVQYSIPDYVHISPECHHLISRIFVADPAKRITIPEIRNHEWF ++v rEi +++l+hpnivr++ev+ ++++l +v+ey+ ggel++++ + g +se+ea+++++q+++g++y+H+++i+HrDlK eN L+d ++ lKi+DFG +k +s+ +s vgt+ Y+APEvl ++ey +k +DvWs+Gv+ly +l g pf++ ++ + ++++ +i++il +++ ++p ++s+e+ +l+++++ dp kR+t+ e+ +h+++ kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekge..lKitDFGlakelessskltsfvgtreYlAPEvlkeney.skkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 213.9 1.6e-65 Protein kinase domain 232 Cluster-5610.0-2R PF07714.14 5 216 48 258 VKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYAAGGELFERICNA---GRFSEDEARFFFQQLISGVSYCHAMQICHRDLKLENTLLDGSQapRLKICDFGYSKSS---VLHSQPKSTVGTPAYIAPEVLLKKEYDGKiADVWSCGVTLYVMLV-GAYPFEDPqEPKNfrkTIQRIlNVQYSIPDYVHISPECHHLISRIFVADPAKRITIPEIRN + +e+ ++l+hpniv++ v++ +l iv+ey++gG+L + + + +++ ++ f +q+ +G++y +++++ Hrdl N Ll+ ++ ki+DfG +++ ++ +++ ++apE+l +k++ k +DvWs Gv+l+ ++ g+ p+++ ++++ +++++ + ++ ++ ++++e ++l+++ + +dp++R t+ e+++ fleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenk..vvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsk.sDvWsfGvllwEiftlgeepypgl.snee...vlekl.kegkrlekpekcpeelyelmkqCweedpeeRptfkelve 100.5 6.2e-31 Protein tyrosine kinase 232 Cluster-5646.0-1F CK1_CK1-Pl 237 496 1 260 YKTERKLGKGGFGQVYVGRRVSGGIERAGPDAIEVALKFEHRNSKGCNYGPPSEWQVYNSLNGCYGIPWVHYKGRQGDFYILVMDILGPSLWDVWNSLGQSMSLSMVACIAVEAISILEKLHLKGFVHGDVKPENFLLGQPGSADEKKLYLVDLGLASRWKDASTGQHVDYDQRPDIFRGTIRYASVHAHLGRTGSRRDDLESLAYTLIFLIKGRLPWQGYQGDNKSFLVCKKKMATSPELACCFCPAPFKQFLEAVTNM yk+erklgkggfgqvyvgrrvs++ +r+g+da+evalkfehr+skgcnygpp ewqvyn+l+g+yg+p vhykgrqgd+yilvmd+lgpslwdvwns gq++s +mvaciaveaisileklh kg+vhgdvkpenfllgqpg+a+ekkl+lvdlglas+wkda++gqhv+ydqrpd+frgt+ryasvhahlgrtgsrrddleslaytlifl++grlpwqgyqgdnk+flvckkkmatspe c+++p++f++f+e+v+n+ ykverklgkggfgqvyvgrrvssakdrtgadalevalkfehrsskgcnygppyewqvyntlggvygvpkvhykgrqgdyyilvmdllgpslwdvwnssgqalseemvaciaveaisileklhakgyvhgdvkpenfllgqpgtaeekklflvdlglaskwkdaasgqhveydqrpdvfrgtvryasvhahlgrtgsrrddleslaytlifllrgrlpwqgyqgdnkgflvckkkmatspeslcalapqafrefvevvvnl 534.8 2.6e-163 CK1_CK1-Pl 844 Cluster-5646.0-1F PF00069.22 237 472 1 215 YKTERKLGKGGFGQVYVGRRVSGGieragpdaIEVALKFEHRNSKGCNY--GPPSEWQVYNSLNGCYGIPWVHYKGRqGDFYILVMDILG-PSLWDVWNsLGQSMSLSMVACIAVEAISILEKLHLKGFVHGDVKPENFLLGQPGSadekkLYLVDLGLASRWKDASTgqhvdydqrPDIFRGTIRYASVHAHLGRTGSRRDDLESLAYTLIFLIKGRLPWQGYQGDNKSFLVCKKKMA y++++klG+G+fG+Vy +++ + g +vA+K ++++ + +E ++ ++l+ + + +++ + d ++lv++++ +l+d+ + +s+s + + ia + ++ le lH kg++H D+KpeN+L+ + g l ++D+Gla++++ s+ + f gt +Y + ++ s+ D+ sl+ +l+ l+ g+ p++g +g++k +++ ++ yekleklGeGsfGkVykaveketg........kivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee.kdelylvleyveggeladlls.rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekge.....lKitDFGlakelesssk.........ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlek 57.0 1.2e-17 Protein kinase domain 844 Cluster-5646.0-1F PF07714.14 238 509 2 258 KTERKLGKGGFGQVYVGRRVSggieRAGPDAIEVALKFEHRNSKGC-NYGPPSEWQVYNSLNGCYGIPWVHYKGRQGDFYILVMDILGPSLWDVWNSL--GQSMSLSMVACIAVEAISILEKLHLKGFVHGDVKPENFLLGQpgsadEKKLYLVDLGLASRWKDASTGqhvdydQRPDIFRGTIRYASVHAHLGRTGSRRDDLESLAYTLIFLIK-GRLPWQGYQGDNKSFLVCKKKMATSPELaccfCPAPFKQFLEAVTNMTFEEEPNYSKLIS ++++klG+G fG+V+ g+ + + + ++va+K +++++ + +e ++ ++l+ + + +++ +i++ + g +L + ++ ++++l+ + ++a++ + +e L+ k +vH d+ N Ll + +k+ + D GLa++ ++ ++ ++ + + +++ ++ + ++ + + D s +l+ +++ g+ p++g++ + + ++k + pe cp+ ++++++ + + ee p++++l++ elgkklGeGafGeVvegtlkg....ekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlse.....nkvvkisDfGLardiekddey......kkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevleklkegkrlekpek....cpeelyelmkqCweedpeeRptfkelve 24.0 1.4e-07 Protein tyrosine kinase 844 Cluster-5660.0-0R RLK-Pelle_RLCK-VI 1 129 79 204 LERYLHGKKNGLKGrpaLTWSARYKVAVGIAEAVRYLHNGTDRCIVHRDIKPSNILISSKKSPKLCDFGLATWTPAPSVPFLCKTVKGTFGYLAPEYFQHGKVSDKTDVYALGIVLLELITGRKPIESK le+ Lhgkk+ + l+W++RykvAvG+a+a++ylH+g++r+++HrD+k+sniL+s++ +p+l+DFGla+w+p+ + +l+k+v+GtFGylapeyf+hGkv++ktdvya g+vlLelitgrkpi+sk leelLhgkkkkkel...leWeeRykvAvGvakaleylHegcerrviHrDvkasniLlsedfepqlsDFGlakwlpekashllvkdveGtFGylapeyfmhGkvnektdvyafgvvlLelitgrkpidsk 205.4 8.3e-63 RLK-Pelle_RLCK-VI 129 Cluster-5660.0-0R PF00069.22 23 127 100 198 RYKVAVGIAEAVRYLHngtDRCIVHRDIKPSNILISSKKSPKLCDFGLATWTPAPSVpflCKTVKGTFGYLAPEYFQHGKVSDKTDVYALGIVLLELITGRKPIE k+a i+e+++ylH +++i+HrD+Kp+NiLi++k+ K++DFGla+ s +++ gt YlAPE ++ ++s k+Dv++lG++l+el+tg+ p + akkiakqilegleylH...skgiiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfs 102.5 1.6e-31 Protein kinase domain 129 Cluster-5660.0-0R PF07714.14 2 127 89 208 ERYLHGKknglKGRPALTWSARYKVAVGIAEAVRYLHNGTdrcIVHRDIKPSNILISSKKSPKLCDFGLATWTPAPSVPFLCKTVKGTFGYLAPEYFQHGKVSDKTDVYALGIVLLELIT-GRKPIE +++L+ k + +++lt + +++a+ iA++++yL++ + +vHrd+ N+L+s++k k++DfGLa + + ++ k + ++apE ++++k++ k+Dv++ G++l E++t g++p++ lkfLrkk....eekekltlkdllsfalqiAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepyp 77.9 4.8e-24 Protein tyrosine kinase 129 Cluster-5663.0-1R IRE1 976 1126 11 179 IQVREGVYENKLAMIKCIDLDGEvRIHQKELSSLMELEGHENVVKYYGVEWDEESCFIALEMCSLTLHDLF------DDEKNFWNEIKS--------------TWDPADDPRTMLLSLIKDIIMGLEYLHSHDLIHRGLNPSNIMIKKECgKFRAKLSNMGSSKRLGGASS v eGvye++ +k+++ + + +ke++ l+ + h n+v+yyg+e de+ +i+le c+l+l+dl +++ +++k+ w+ p ++ll l++di+ Gl +lh+ +++hr l+P n++i k+ ++akls+mg skrl+ s tvvfeGvyegrevavkrllrsht.dkavkeiknliasdehsnivryygleqdedfvyislercalslddlikaslkvlekdddsedvkalklddlekngkeiklwkenGkpsplllklmrdivaGlvhlhelgivhrdlkPqnvliskdr.tlsaklsdmglskrlaedvs 84.5 5.6e-26 IRE1 1142 Cluster-5663.0-1R PF00069.22 973 1126 10 153 GKSIQVREGV--YENKLAMIKCIDLDGEVRIHQ----KELSSLMELEgHENVVKYYGVEWDEESCFIALEMCSLT-LHDLFDDEKNFWNEikstwdpaddprtMLLSLIKDIIMGLEYLHSHDLIHRGLNPSNIMIKkECGKfrAKLSNMGSSKRLGGASS G++ +V ++v ++k +K+i+ + + ++ +E++ l +l+ h+n+v++y+v ++++ ++ le+++ + l+dl +++++ +e + +++k i+ gleylHs+ +iHr l p+Ni+i+ e g+ K++ G +k+l s+ GsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklk.hpnivrlyevfeekdelylvleyveggeladllsrkgslsee.............eakkiakqilegleylHskgiiHrDlKpeNiLid.ekge..lKitDFGlakelesssk 56.2 2.1e-17 Protein kinase domain 1142 Cluster-5663.0-1R PF07714.14 999 1120 45 153 VRIHQKELSSLMELeGHENVVKYYGVEWDEESCFIALEMCSL-TLHDLFDDEknfwneikstWDPADDPRTMLLSLIKDIIMGLEYLHSHDLIHRGLNPSNIMIKKecgKFRAKLSNMGSSKR + +e++ +++l h+n+vk++gv +ee+ +i +e+++ +L++ ++ + + + lls++++i G+eyL+s++l+Hr l N+++++ + +k+s G +++ keefleeakimkkl.khpnivkllgvctkeepllivteyvegGdLlkfLrkk..........eekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlse...nkvvkisDfGLard 39.5 2.5e-12 Protein tyrosine kinase 1142 Cluster-5767.0-1R CMGC_CLK 37 96 2 61 KILRKIGEGTFGQVLECWDRETKQFVAVKIVRSIKKYREAAMVEIDVLQLLGRYDRNSSR kil k+gegtfg+vlecwdre+k++va+k+vrsikkyr+aam+eidvl+ l+++d+ +sr kilskmgegtfgrvlecwdrerkelvaikvvrsikkyrdaamieidvlkklakndklgsr 85.2 3e-26 CMGC_CLK 423 Cluster-5767.0-1R PF00069.22 39 87 4 55 LRKIGEGTFGQVLECWDRETKQFVAVKIVRSIKKYR---EAAMVEIDVLQLL l+k+GeG+fG+V+++ ++et++ vAvK+++ k+ ++++ Ei +l+ l leklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkkl 28.3 6.9e-09 Protein kinase domain 423 Cluster-5767.0-2R CMGC_CLK 89 308 109 327 DMIEIAAVMHDMRLIHTDLKPENILFVSPDYVKIPDVRvaSWSLREGSDYKRLPKSSAIKVIDFGSAVYELRDHNYIVSTRHYRAPEVILGLGWSYPCDIWSVGCILVELCSGEALFQTHENLEHLAMMERVLGPLPQYMLKRVDRQAHKYIKWN-RLDWPEGATSRESIKAVVKLPRLQNLVMQHVDHSAGDLIDLLLGLLRYDPSVRTTAHEALKHPFF +++e a mh++rlihtdlkpenil+vs +yvk+pd + s s +eg+ +krlpkssaik+idfgsa+++ ++h+++vstrhyrapevilglgwsypcd+wsvgcilvelcsgealfqthenlehlammervlgplp+ m+kr+dr+a+ky++ rl+wpega+sres+kav klprl+nl++++vdhsag+lidll gll+ydps r ta+ealkhpff qllesvaymhelrlihtdlkpenillvsseyvkvpdyk..srsskegkafkrlpkssaiklidfgsatfdeqehssvvstrhyrapevilglgwsypcdlwsvgcilvelcsgealfqthenlehlammervlgplpehmikradrraekyfrrgarlnwpegaasreslkavkklprlknlilkkvdhsagelidllqgllkydpserltakealkhpff 382.1 1.4e-116 CMGC_CLK 423 Cluster-5767.0-2R PF00069.22 86 308 103 264 YLEDMIEIAAVMHDMRLIHTDLKPENILFVSpdyvkipdvrvaswslregsdykrlpkSSAIKVIDFGSAVYELRDH--NYIVSTRHYRAPEVILGLGWSYPCDIWSVGCILVELCSGEALFQTHE-------NLEHLAMMERVLGplpqymlkrvdR----------QahkyikwnrldwpegatsresikavvklprlqnlvmqhvdhsAGDLIDLLLGLLRYDPSVRTTAHEALKHPFF +++ ++e + +H++++iH DlKpeNiL+ + ++ +K++DFG a +++ + +v tr+Y+APEv+ + + s ++D+Ws+G+il+el +g+ +f+ ++ +l++l ++ ++lg +++dll ll++dp+ R ta+e+l+hp++ iakqilegleylHskgiiHrDlKpeNiLide...........................kgelKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg...........etkeklpeasel..........................................seeakdllkkllkkdpkkRltaeellqhpyl 103.7 7e-32 Protein kinase domain 423 Cluster-5767.0-2R PF07714.14 95 219 118 221 AVMHDMRLIHTDLKPENILFVSpdyvkipdvrvaswslregsdykrlpkSSAIKVIDFGSAVYELRDHNYIVST-----RHYRAPEVILGLGWSYPCDIWSVGCILVELCS-GEALFQTHENLEHLAMMER + +++++l+H dl N+L + ++ +k+ DfG a +d++y +++ ++ apE++ + D+Ws G +l E+++ ge +++ +n e l+++++ eyLeskklvHrdlaarNvLlse...........................nkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevleklke 28.5 5.8e-09 Protein tyrosine kinase 423 Cluster-5767.1-1R CMGC_CLK 37 363 2 327 KILRKIGEGTFGQVLECWDRETKQFVAVKIVRSIKKYREAAMVEIDVLQLLGRYDRNSSRCVELRNWFDYRNHICLVFEKLGPSLFDFLRKNSYRSFPVDLVREIGRQVLECIAFMHDMRLIHTDLKPENILFVSPDYVKIPDVRvaSWSLREGSDYKRLPKSSAIKVIDFGSAVYELRDHNYIVSTRHYRAPEVILGLGWSYPCDIWSVGCILVELCSGEALFQTHENLEHLAMMERVLGPLPQYMLKRVDRQAHKYIKWN-RLDWPEGATSRESIKAVVKLPRLQNLVMQHVDHSAGDLIDLLLGLLRYDPSVRTTAHEALKHPFF kil k+gegtfg+vlecwdre+k++va+k+vrsikkyr+aam+eidvl+ l+++d+ +srcv+l++wfdyrnhic+vfeklgpsl+dflrkn+yrsfp+dlvr++grq+le++a+mh++rlihtdlkpenil+vs +yvk+pd + s s +eg+ +krlpkssaik+idfgsa+++ ++h+++vstrhyrapevilglgwsypcd+wsvgcilvelcsgealfqthenlehlammervlgplp+ m+kr+dr+a+ky++ rl+wpega+sres+kav klprl+nl++++vdhsag+lidll gll+ydps r ta+ealkhpff kilskmgegtfgrvlecwdrerkelvaikvvrsikkyrdaamieidvlkklakndklgsrcvqlkewfdyrnhicivfeklgpslydflrknkyrsfpidlvrdlgrqllesvaymhelrlihtdlkpenillvsseyvkvpdyk..srsskegkafkrlpkssaiklidfgsatfdeqehssvvstrhyrapevilglgwsypcdlwsvgcilvelcsgealfqthenlehlammervlgplpehmikradrraekyfrrgarlnwpegaasreslkavkklprlknlilkkvdhsagelidllqgllkydpserltakealkhpff 606.0 1.1e-184 CMGC_CLK 478 Cluster-5767.1-1R PF00069.22 39 363 4 264 LRKIGEGTFGQVLECWDRETKQFVAVKIVRSIKKYR---EAAMVEIDVLQLLGrydrnSSRCVELRNWFDYRNHICLVFEKLG-PSLFDFLRKNSYrsFPVDLVREIGRQVLECIAFMHDMRLIHTDLKPENILFVSpdyvkipdvrvaswslregsdykrlpkSSAIKVIDFGSAVYELRDH--NYIVSTRHYRAPEVILGLGWSYPCDIWSVGCILVELCSGEALFQTHE-------NLEHLAMMERVLGplpqymlkrvdR----------QahkyikwnrldwpegatsresikavvklprlqnlvmqhvdhsAGDLIDLLLGLLRYDPSVRTTAHEALKHPFF l+k+GeG+fG+V+++ ++et++ vAvK+++ k+ ++++ Ei +l+ l +++ v+l ++f ++++lv+e + +l+d+l++++ ++ + +++i +q+le ++++H++++iH DlKpeNiL+ + ++ +K++DFG a +++ + +v tr+Y+APEv+ + + s ++D+Ws+G+il+el +g+ +f+ ++ +l++l ++ ++lg +++dll ll++dp+ R ta+e+l+hp++ leklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklk.....hpnivrlyevfeekdelylvleyveggeladllsrkgs..lseeeakkiakqilegleylHskgiiHrDlKpeNiLide...........................kgelKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg...........etkeklpeasel..........................................seeakdllkkllkkdpkkRltaeellqhpyl 171.5 1.4e-52 Protein kinase domain 478 Cluster-5767.1-1R PF07714.14 38 274 3 221 ILRKIGEGTFGQVLECWDR----ETKQFVAVKIVRSIKKYR--EAAMVEIDVLQLLgrydrNSSRCVELRNWFDYRNHICLVFEKL-GPSLFDFLRKN-SYRSFPVDLVREIGRQVLECIAFMHDMRLIHTDLKPENILFVSpdyvkipdvrvaswslregsdykrlpkSSAIKVIDFGSAVYELRDHNYIVST-----RHYRAPEVILGLGWSYPCDIWSVGCILVELCS-GEALFQTHENLEHLAMMER + +k+GeG+fG+V e+ + ++++ vavK++++ ++ + e+ + e+++++ l + + v+l + ++++++v+e + g +L +fLrk+ + +++ ++ + ++ +q+ + ++++++++l+H dl N+L + ++ +k+ DfG a +d++y +++ ++ apE++ + D+Ws G +l E+++ ge +++ +n e l+++++ lgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkkl.....khpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlse...........................nkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevleklke 70.8 6.9e-22 Protein tyrosine kinase 478 Cluster-578.0-2F CMGC_CDK-CDK8 31 201 1 173 YDVIGKIGEGTYGLVFLAKIKS--NRSKPIAIKKFKQSKDGDGVSPTAIREIMLLREISHENVVKLANVHINHADMSLYLAFDYAEHDLYEIIRHHRDKVNQSINQYTVKSLLWQLLNGLNYLHSNWIIHRDLKPSNILVMGDGEEQGVVKIADFGLARIYQAPLKPLSDNGV y+++gkigegtyglv+la+ k +r+++iaikkfkqsk+gdgvsptaireimllrei+hen+vkl nvhin+admslylafdyae+dlyeiirhhr+kv++s+n+ytvksllwqllnglnylhsnwiihrdlkpsnilvmg++ee+g+vkiadfglari+qapl+plsdngv yelvgkigegtyglvylarskepahrgtkiaikkfkqskegdgvsptaireimllreirhenivklvnvhinradmslylafdyaeydlyeiirhhrekvelslnaytvksllwqllnglnylhsnwiihrdlkpsnilvmgedeehgivkiadfglarifqaplrplsdngv 344.7 3.6e-105 CMGC_CDK-CDK8 216 Cluster-578.0-2F PF00069.22 31 194 1 153 YDVIGKIGEGTYGLVFLAKiKSNRSKPIAIKKFKQSKDGDGVSPTAIREIMLLREISHENVVKLANVHINhaDMSLYLAFDYAEHD-LYEIIRhhrdkVNQSINQYTVKSLLWQLLNGLNYLHSNWIIHRDLKPSNILVMGDGEeqgvVKIADFGLARIYQAPLK y ++ k+GeG++G V+ a+ +++++k +A+Kk+k++k+ + +++rEi +l++++h+n+v+l +v + + +lyl ++y+e++ l ++++ ++s+++ ++k++++q+l+gl+ylHs+ iiHrDlKp+NiL+ +ge +Ki+DFGla+ ++ k yekleklGeGsfGkVykav.eketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee..kdelylvleyveggeladlls.....rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekge....lKitDFGlakelesssk 134.5 2.7e-41 Protein kinase domain 216 Cluster-578.0-2F PF07714.14 35 190 5 155 GKIGEGTYGLVFLAKIK---SNRSKPIAIKKFKQSKDGDGvSPTAIREIMLLREISHENVVKLANVHInhADMSLYLAFDYAEH-DLYEIIRHHRDKvnQSINQYTVKSLLWQLLNGLNYLHSNWIIHRDLKPSNILVMGdgeeQGVVKIADFGLARIYQ k+GeG++G V+ +++k ++++ +a+K++k++++ + + ++e+ ++++++h+n+vkl v + + +l++ ++y+e+ dL + +r++++k ++++ ++ s+ +q+ +G++yL+s+ ++Hrdl N+L+ + vvki+DfGLar + kklGeGafGeVvegtlkgekekkevkvavKtlkeeateee.keefleeakimkklkhpnivkllgvct..keepllivteyvegGdLlkfLrkkeek..ekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlse....nkvvkisDfGLardie 93.8 6.6e-29 Protein tyrosine kinase 216 Cluster-5832.0-1F TKL-Pl-4 32 281 24 253 SVKLLDWGeegHRTEAEIASLRAAFTQEVAVWHKLDHPNVTKFIGATMgssdlnvqtenghigmPSNICCVVVEYLPGGALKSYLIKNRRKKLAFKVVVQIALDLARGLSYLHSQKIVHRDVKTENMLLDKNRTVKIADFGVARVEASnPNDMTGETGTLGYMAPEVLNGNPYNRKCDVYSFGICLWETYCCDMPYPDLSFSEVTSAVVRQNLRPEIPRCCPSSLANVMKRCWDANPDKRPEMDEVVAML +vK+l++g +++e+e+a+l+++f+qevav++kl+H+nv+kfiga++ ++ +c+v+eyl+gg+lk+yl+k+++kkl++kvvv++ald+argl+ylhs+kivHrD+k+en+lld++++vKiaDfGvarvea+ +++mt+etGt+++maPEvl+++py+rk+Dvysfgi+lWe++++++py dl++ ++++avv++nlRpeip+++p++la++++rcw+a+p+kRpe++e+v++l avKileag...eekeeeaaelekefkqevavlsklkHknvvkfigact................kepalcivteylkggslkkylekkkkkklklkvvvklaldiargleylhskkivHrDlkaenllldeekvvKiaDfGvarveaq.seemtaetGtyrwmaPEvlekkpydrkvDvysfgivlWelltgkvpyedltplqaavavvqknlRpeipkevpealaellercwkadpekRpefseivkll 349.6 8.6e-107 TKL-Pl-4 392 Cluster-5832.0-1F PF07714.14 52 281 44 260 LRAAFTQEVAVWHKLDHPNVTKFIGATMgssdlnvQ--TenghigmpsniCCVVVEYLPGGALKSYLIKN-RRKKLAFKVVVQIALDLARGLSYLHSQKIVHRDVKTENMLLDKNRTVKIADFGVARVE--ASNPNDMTGETGTLGYMAPEVLNGNPYNRKCDVYSFGICLWETYC-CDMPYPDLSFSEVTSAVvRQNLRPEIPRCCPSSLANVMKRCWDANPDKRPEMDEVVAML +++f++e+++ +kl+hpn+ k++g+ + + + ++v+ey++gG L+++L k+ +++kl +k ++++al++A+G++yL+s+k+vHrd+ + N+Ll++n++vki+DfG+ar ++ ++ ++++ + +mapE+l+ + ++ k Dv+sfG++lwE ++ +++pyp+ls +ev++++ +++ r e p+ cp++l+++mk+Cw+++p++Rp+++e+v l ekeefleeakimkklkhpnivkllgvct.......keep...........llivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevlekl.kegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 195.2 8e-60 Protein tyrosine kinase 392 Cluster-5832.0-1F PF00069.22 54 279 43 260 AAFTQEVAVWHKLDHPNVTKFIGATMGssdlnvqtenghigmpSNICCVVVEYLPGGALKSYLIknRRKKLAFKVVVQIALDLARGLSYLHSQKIVHRDVKTENMLLDKNRTVKIADFGVARVEASNPNdMTGETGTLGYMAPEVLNGNPYNRKCDVYSFGICLWETYCCDMPYPDLSFSEVTSAVVRQ-----------NLRPEIPRCCPSSLANVMKRCWDANPDKRPEMDEVVA ++++E+++ +kl+hpn+ +++++ ++ ++v+ey++gg l+++l r+++l+ + + +ia +++gl+ylHs++i+HrD+K+eN+L+d+++ +Ki+DFG+a+ s+ + +t ++gt Y+APEvl++n+y +k+Dv+s G+ l+e ++ +p+++ + +e +++ ++q ++ + ++ +++++ +++k++++ +p kR+ ++e+++ kkvlrEikilkklkhpnivrlyevfee................kdelylvleyveggeladlls..rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk.ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellq 157.0 3.8e-48 Protein kinase domain 392 Cluster-5896.0-0R CMGC_MAPK 168 452 4 288 IKPIGRGAYGIVCSSINRETNEKVAIKKIHNAFENRIDALRTLRELKLLRHLRHENVIALKDVMLPNHKRSFKDVYMVYELMDTDLHQIIKSSQTLTNDHCQYFLFQLLRGLKYLHSANILHRDLKPGNLLINANCDLKICDFGLARTSSSQGQFMTEYVVTRWYRAPELLLCCDNYGTSIDVWSVGCIFAELLGRKPIFPGTECLNQLKLIINILGSQRENDLEFIDNPKARKYIKSLPYTLGTPLSRLYPNAHPLALDLLQKMLVFDPAKRISVTEALQHPYM +++iG+G+yg+vcs++++et+ekvaikki+++fen+ida r+lre+kllr+l+hen+++lkdv+ p++k++fkDvy+v+elmdtdlhq+iks+++lt++h+qy+l+qllrglkylhsan+lhrDlkp+nll+nanc+lkicDfGlar++ss+ +++teyvvtrwyraPelll++++Y+++iDvWsvGCifaell rkp+fpg+++++qlkli++++G+++e+dle+++++kar+y+k+lp + +++l++++p++++laldLl+++l+fdP+kri+++eal+hpy+ eeviGkGsygvvcsavdtetgekvaikkiedvfenlidakrvlreikllrrlehenivelkdvlkpaekeefkDvyivlelmdtdlhqviksndelteehvqyllyqllrglkylhsanvlhrDlkpknlllnancklkicDfGlarsassetdllteyvvtrwyraPelllssskYtsaiDvWsvGCifaelltrkplfpgkdvvdqlkliteliGtpseedlesvrsekarrylkklpkkakkslkkkfpkvdelaldLlerllafdPkkritaeealahpyl 472.9 2.6e-144 CMGC_MAPK 585 Cluster-5896.0-0R PF00069.22 166 452 2 264 VPIKPIGRGAYGIVCSSINRETNEKVAIKKIHNAFENRIDALRTLRELKLLRHLRHENVIALKDVMLPnhkrsFKDVYMVYELMDTD-LHQIIKSSQTLTNDHCQYFLFQLLRGLKYLHSANILHRDLKPGNLLINANCDLKICDFGLARTSSSQGQfMTEYVVTRWYRAPELLlCCDNYGTSIDVWSVGCIFAELLGRKPIFP---GTE----CLNQLKLIINILGsQRENDLEFIDNPkarkyikslpytlgtplsrlypnaHPLALDLLQKMLVFDPAKRISVTEALQHPYM ++ +G+G++G V + +++et+++vA+Kki + ++ + ++lrE+k+l++l+h+n++ l++v+ +++y+v e+++++ l+++++ +++l++++++ ++ q+l+gl+ylHs++i+HrDlKp N+Li+ + +lKi+DFGla+ +s+ + +t++v+tr+Y+APE+l +y++++DvWs+G+i++ell +kp+f+ g+e l+ql+ i++ilg + +++l+ ++ + a+dll+k+l dp kR++++e+lqhpy+ ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee.....kdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk.ltsfvgtreYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.etkeklpeasel........................seeakdllkkllkkdpkkRltaeellqhpyl 238.8 4.4e-73 Protein kinase domain 585 Cluster-5896.0-0R PF07714.14 169 362 5 201 KPIGRGAYGIVCSSINR----ETNEKVAIKKIHNAFENRiDALRTLRELKLLRHLRHENVIALKDVMLpnH--KrsfkdVYMVYELMDT-DLHQIIKSS---QTLTNDHCQYFLFQLLRGLKYLHSANILHRDLKPGNLLINANCDLKICDFGLARTS---SSQGQFMTEYVVTRWYrAPELLLCCDnYGTSIDVWSVGCIFAELLG k +G+Ga+G V++ + + +++ kva+K++++ +++ + + l+e+k++++l+h+n+++l v++ + + +++v e+++ dL++ ++++ ++lt ++ f +q+ +G++yL+s +++Hrdl N L++ n ki+DfGLar+ +++ + ++ + +W+ apE l + + ++ DvWs G + E++ kklGeGafGeVvegtlkgekekkevkvavKtlkeeatee.ekeefleeakimkklkhpnivkllgvct..keep.....llivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWm.apEslkekk.ftsksDvWsfGvllwEift 113.9 4.8e-35 Protein tyrosine kinase 585 Cluster-5908.0-2F CMGC_GSK 91 240 1 150 AERVVGHGSFGVVFQAKCLETGETVAIKKVLQDKRYKNRELQTMRLLDHPNVVSLKHCFFSTTEKDELYLNLVLEYVPETVNRVIKHYNKLNQRMPLIYVKLYSYQIFRALSYIHRGIGVCHRDIKPQNVLVNPHTHQLKLCDFGSAKVL aervvg+gsfgvvfqakcletgetvaikkvlqdkryknrelq+mrlldhpnvv+lkh+ffsttekdelylnlvleyvpetv+rv+khy+klnqr+pliyvkly yqi+ral+yih+++gvchrdikpqn+lvnp+thqlklcdfgsakvl aervvgtgsfgvvfqakcletgetvaikkvlqdkryknrelqimrlldhpnvvalkhlffsttekdelylnlvleyvpetvyrvakhysklnqrlpliyvklytyqicralayihkvvgvchrdikpqnllvnpkthqlklcdfgsakvl 306.4 1.3e-93 CMGC_GSK 240 Cluster-5908.0-2F PF00069.22 89 239 1 147 YMAERVVGHGSFGVVFQAKCLETGETVAIKKVLQDKRYKN------RELQTMRLLDHPNVVSLKHCFFStteKDELYlnLVLEYVPET-VNRVIKhynkLNQRMPLIYVKLYSYQIFRALSYIHrGIGVCHRDIKPQNVLVNpHTHQLKLCDFGSAKV y ++ +G GsfG+V++a+ etg++vA+Kk+ ++k+ k+ rE++ ++ l+hpn+v l+++f + kdely lvleyv+++ ++++++ ++ ++ +k + +qi+++l+y+H g++HrD+Kp+N+L++ ++ +lK++DFG ak yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee...kdely..lvleyveggeladlls....rkgslseeeakkiakqilegleylH.skgiiHrDlKpeNiLid.ekgelKitDFGlake 119.9 8.2e-37 Protein kinase domain 240 Cluster-5908.0-2F PF07714.14 92 238 4 152 ERVVGHGSFGVVFQAKCL----ETGETVAIKKVLQDKRYK-----NRELQTMRLLDHPNVVSLKHCFFsttEKDElyLNLVLEYVPETVNRVIKHYNKLNQRMPLIYVKLYSYQIFRALSYIHRgIGVCHRDIKPQNVLVNpHTHQLKLCDFGSAK ++ +G+G+fG V+++++ ++ +va+K++ ++++ + +e+++m+ l+hpn+v+l + ++++ l +v+eyv++ + + ++ ++++ l + +++qi ++++y+++ + Hrd+ +NvL++ ++++ k++DfG a+ gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvct...keep..llivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLes.kklvHrdlaarNvLls.enkvvkisDfGLar 65.6 2.7e-20 Protein tyrosine kinase 240 Cluster-5926.0-2R CAMK_CDPK 10 107 1 98 YSLGKELGRGQFGVTHLCTDLSTGQQYACKSISKRKLVTKSDKEDMRREIQIMQHLSGQPNIVEFKGAYEDKQSVHLVMELCEGGELFDRITAKGHYS y+lgkelGrG+fGv++l+t+ +tg+++A+Ksiskrkl++++d ed+rre++i++hlsg++n+v++kgayedk+svhlvmelceggel+dri+a+g+ys yelgkelGrGefGvvrlatekatgeevAvKsiskrklskaedvedvrrevkilkhlsghknvvqlkgayedkdsvhlvmelceggelldrilargkys 141.9 2.1e-43 CAMK_CDPK 107 Cluster-5926.0-2R PF00069.22 10 105 1 94 YSLGKELGRGQFGVTHLCTDLSTGQQYACKSISKRKLVTKSDkEDMRREIQIMQHLSgQPNIVEFKGAYEDKQSVHLVMELCEGGELFDRITAKGH y+ ++lG+G+fG+ +++ +tg+++A+K i+k+k k++ ++++rEi+i+++l+ pniv++++++e+k++++lv+e++eggel+d++++kg+ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklk.hpnivrlyevfeekdelylvleyveggeladllsrkgs 82.3 2.3e-25 Protein kinase domain 107 Cluster-5926.0-2R PF07714.14 12 102 3 94 LGKELGRGQFGVTHLCTDL----STGQQYACKSIskRKLVTKSDKEDMRREIQIMQHLsGQPNIVEFKGAYEDKQSVHLVMELCEGGELFDRITA lgk+lG+G+fG + +t ++ ++ a K++ ++ t+++ke++ +e++im++l +pniv++ g++ +++++ +v+e++egG+L + +++ lgkklGeGafGeVvegtlkgekekkevkvavKtl..keeateeekeefleeakimkkl.khpnivkllgvctkeepllivteyvegGdLlkfLrk 50.9 8.1e-16 Protein tyrosine kinase 107 Cluster-5933.0-0R CAMK_CDPK 208 282 1 72 YEIGEEVGRGHFGYTCRAKFKKgelKGQDVAVKVIPKAKMTTAIAIEDVRKEVKILRALTGHNNLIQFYDAYEDQ ye+g+e+GrG+fG++++a+ k+ +g++vAvK+i+k+k+++a ++edvr+evkil++l+gh+n++q+++ayed+ yelgkelGrGefGvvrlateka...tgeevAvKsiskrklskaedvedvrrevkilkhlsghknvvqlkgayedk 74.1 1e-22 CAMK_CDPK 282 Cluster-5933.0-0R PF00069.22 208 281 1 69 YEIGEEVGRGHFGYTCRAKFKKgelKGQDVAVKVIPKAKMTTAIAiEDVRKEVKILRALTgHNNLIQFYDAYED ye e++G+G fG +a+ k+ +g+ vAvK+i k k++ ++v++E+kil+ l h+n++++y+++e+ yekleklGeGsfGkVykaveke...tgkivAvKkikkekakkkke.kkvlrEikilkklk.hpnivrlyevfee 33.6 1.7e-10 Protein kinase domain 282 Cluster-5933.0-0R PF07714.14 209 279 2 70 EIGEEVGRGHFGYTCRAKFK-KGELKGQDVAVKVIPKAKMTTAiaIEDVRKEVKILRALtGHNNLIQFYDAY e+g+++G+G+fG ++++ k + e k ++vavK++ + ++ ++ e++ +e+ki+++l h+n+++++ ++ elgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateee..keefleeakimkkl.khpnivkllgvc 31.0 9.9e-10 Protein tyrosine kinase 282 Cluster-5948.0-2F CMGC_GSK 1 102 182 283 DIWSAGCVLAELLLGQPLFPGESGVDQLVEIIKVLGTPTREEIKCMNPNYTEFKFPQIKAHPWHKIFHKRMPPEAVDLVSRLLQYSPNLRCTALDALTHPFF diwsagcvlaelllgqplfpgesgvdqlveiikvlgtptreeikcmnpnytefkfpqikahpwhk+f+kr+ppeavdlvsrllqyspnlrctal+al+hpff diwsagcvlaelllgqplfpgesgvdqlveiikvlgtptreeikcmnpnytefkfpqikahpwhkvfkkrlppeavdlvsrllqyspnlrctalealvhpff 216.3 3.9e-66 CMGC_GSK 220 Cluster-5948.0-2F PF00069.22 1 102 179 264 DIWSAGCVLAELLLGQPLFP---GES----GVDQLVEIIKVLGtptreE--IKCMNP--NytefkfpqikahpwhkifhkrmPPEAVDLVSRLLQYSPNLRCTALDALTHPFF D+Ws+G++l+ell g+p+f+ g++ +dql++i+k+lg e k ++ ++ea dl+++ll++ p+ R+ta ++l hp++ DvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.....etkeklpeasel......................seeakdllkkllkkdpkkRltaeellqhpyl 51.1 7.5e-16 Protein kinase domain 220 Cluster-5967.0-0R RLK-Pelle_RLCK-VI 29 131 165 267 YRYLAPEYFMYGKVNYKIDVYAFGVVLLELLSGRKPISNDRPKGQESLVMWAKPILSSGKFVQLLDPSLGSNYDQEQVEKMVLAAALCIRRAPRARPHMTLVL + ylapeyfm+Gkvn k+dvyafgvvlLel++grkpi+++++kg+eslv+wakp+l+++k+ +l+dp+l +++d+e++e++vlaa+lcir+++++rp+++ vl FGylapeyfmhGkvnektdvyafgvvlLelitgrkpidsksakgkeslvlwakplleekklkelvdpkleteadeeelerlvlaaslcirksakrrpslkevl 146.5 7.3e-45 RLK-Pelle_RLCK-VI 289 Cluster-5967.0-0R PF07714.14 26 131 167 257 LFLYRYLAPEYFMYGKVNYKIDVYAFGVVLLELLS-GRKPisndrpkgqeslvmwaKPILSSGKFVQLLDPSLGSNYDQEQVEKMVLAAALCIRRAPRARPHMTLVL + ++++apE ++++k++ k Dv++fGv+l E+++ g++p p ls+ ++++ l+ + + ++ e++ C+++ p+ Rp+++ ++ klpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep................ypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelv 30.4 1.4e-09 Protein tyrosine kinase 289 Cluster-5967.0-0R PF00069.22 23 78 155 210 EHTLFLYRYLAPEYFMYGKVNYKIDVYAFGVVLLELLSGRKPISNDRPKGQESLVM ++ +YlAPE + ++ k+Dv++ Gv+l+ell+g+ p s+++ k + + + tsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekel 28.6 5.5e-09 Protein kinase domain 289 Cluster-6039.1-2R CAMK_CAMKL-CHK1 42 297 1 256 YEVGRTIGEGTFAKVKFARNSETGEHVALKILDKDKVLKNKMAEQIKREIATMKLIKHPHVVRLYEVMGSKTKIFIVLEFVTGGELFDKIVNHGRMQEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDASGNLKVSDFGLSALSRQIRDDGLLHTTCGTPNYVAPEVLNDLGYDGATADLWSCGVILFVLLAGYLPFDDANLMNLYKKISSAEFTCPPWLSFSAKKLIARILDPNPMTRIIIPEILEDEWF ye+Gr++Gegtfakvk+ar+ etge+va+k+ldk+kvlk+k++eqikrei+++kl++hp+vvrl+ev+ +k+ki++vle+v+GGelf+ki+++gr++edearkyfqqli+avdychsrgvyhrdlkpenllld++gnlkvsdfGlsal++q+r+dgllhttcGtP+yvaPevl++ gydga+ad+WscGvilfvllagylPf+d+nl++ly+ki++aef++p+wls +akkli+r+ldpnp+tri i eile+eWf yelGrllGegtfakvklardletgesvaikvldkekvlkaklveqikreisvlklvrhpnvvrllevlatkskiylvleyvkGGelfekiakkgrlkedearkyfqqlisavdychsrgvyhrdlkpenllldekgnlkvsdfGlsalaeqlredgllhttcGtPayvaPevlkkkgydgakadvWscGvilfvllagylPfedenlvelyrkilkaefklpkwlskeakklisrlldpnpetritieeileeeWf 452.8 2.3e-138 CAMK_CAMKL-CHK1 558 Cluster-6039.1-2R PF00069.22 42 297 1 264 YEVGRTIGEGTFAKVKFARNSETGEHVALKILDKDKVLKNKMaEQIKREIATMKLIKHPHVVRLYEVMGSKTKIFIVLEFVTGGELFDKIVNHGRMQEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDASGNLKVSDFGLSALSRQIRDdglLHTTCGTPNYVAPEVLNDLGYdGATADLWSCGVILFVLLAGYLPFDDANLMNLYK----------KIS---SAEFTCPPWLSFSAKKLIARILDPNPMTRIIIPEILEDEWF ye+ +++GeG+f+kV a+++etg++vA+K+++k+k k+k +++ rEi+ +k +khp++vrlyev+ +k+++++vle+v ggel+d + ++g ++e+ea+k+++q++++++y+Hs+g+ HrDlKpeN+L+d +g+lK++DFGl++ ++ + l++ +gt++Y+APEvl++ +y ++++D+Ws+Gvil+ ll+g pf + + + ++ ki + ++ + ls +ak+l+ ++l+ +p++R+ + e+l+++++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeney.skkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 241.2 8e-74 Protein kinase domain 558 Cluster-6039.1-2R PF07714.14 44 292 3 257 VGRTIGEGTFAKVKFARNS----ETGEHVALKILDKDKvlKNKMAEQIKREIATMKLIKHPHVVRLYEVMGSKTKIFIVLEFVTGGELFDKIVNH---GRMQEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDASGNLKVSDFGLSALSRQIRDDGLLHTTCGTPNYVAPEVLNDLGYDgATADLWSCGVILFVLLA-GYLPFDDANLMNLYKKISSA-EFTCPPWLSFSAKKLIARILDPNPMTRIIIPEIL +g+++GeG+f++V ++ + ++ +va+K+l++++ +++ e++ +e+++mk +khp++v+l+ v+ ++ +++iv+e+v+gG+L + + ++ +++ ++ ++ +q+ ++++y +s+ + Hrdl N Ll+ + k+sDfGL+ ++ + +++ +++apE+l++ + +D Ws Gv+l+ ++ g p+ + + +++++k+++ + ++p + + ++l+ + ++ +p R + e++ lgkklGeGafGeVvegtlkgekekkevkvavKtlkeea..teeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkft.sksDvWsfGvllwEiftlgeepypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelv 123.8 4.7e-38 Protein tyrosine kinase 558 Cluster-6043.0-2R RLK-Pelle_RLCK-IV 5 132 36 161 LRTEFRSEVELLSKIEHRNLVRLIGYINEGDERLIITEYVQNGTLREHLDGVKGKILDFNQRLQITIDIAHGLTYLHLYSgsEKQIIHRDVKASNILLTKRMNAKVADFGFAKLGAVDSDRSHVSTKV l++efrseve+lsk+eh+nlv+l+gy++e+derl+++eyv+nG+lrehldg++gkild+++rl+i+id+ah+ltylhly+ +++iihrd+k+sniLlt+++ akvadfgfa+lg+ +++ +hvst+v lsaefrsevevlskvehlnlvkllgyleeederllvveyvanGnlrehldglegkildlstrleiaidvahaltylhlya..drpiihrdikssniLlteslrakvadfgfarlgpseegathvstqv 197.2 2.7e-60 RLK-Pelle_RLCK-IV 132 Cluster-6043.0-2R PF07714.14 6 123 45 158 RTEFRSEVELLSKIEHRNLVRLIGYINEGDERLIITEYVQNGTLREHLDGV-KGKILDFNQRLQITIDIAHGLTYLHlysgsEKQIIHRDVKASNILLTKRMNAKVADFGFAKLGAVDS ++ef +e+++++k++h+n+v+l+g + ++++ li+teyv++G+L+++L + + l++++ l+++++iA+G+ yL+ +k+++Hrd+ a N+Ll++++ +k++DfG a+ d+ keefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLe.....skklvHrdlaarNvLlsenkvvkisDfGLardiekdd 98.6 2.3e-30 Protein tyrosine kinase 132 Cluster-6043.0-2R PF00069.22 7 123 43 152 TEFRSEVELLSKIEHRNLVRLIGYINEGDERLIITEYVQNGTLREHLDgvKGKILDFNQRLQITIDIAHGLTYLHLYSgsekqIIHRDVKASNILLTKRMNAKVADFGFAKLGAVDS +++++E+++l k++h+n+vrl+++++e de+++++eyv++g+l ++l + ++l+ ++ +i+ i++gl ylH + iiHrD+K +NiL++++ + K++DFG+ak +s kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls..rkgslseeeakkiakqilegleylHskg.....iiHrDlKpeNiLidekgelKitDFGlakelesss 90.0 1e-27 Protein kinase domain 132 Cluster-605.0-0R RLK-Pelle_LRR-VII-2 1 152 12 156 YGGLLPGGVHVAVKVLVLGSTMSDQEAAREFEYLGRIKHPNLVPLTGYCLAGDQRIAIYEYMENGNLQHFLHDLPLGIQTTEDWTTDTWEEEDDNNGIQnvgmkgsLITWRFRHKIALGTARALAFLHHGCSPPIIHKDVKASSVYLDLNLE y g+lpgg++v+vkvlv gs+++++e+a+e+e Lgri+hpnl++L+GyC+ag++r+++ye++engnlq++Lh+lp g q++edw++dtWeee++++ + +Wr+rh+ialG+araLafLhhgcsp+i+h+dvkas+++ld +le ykgvlpgglkvvvkvlvegsavnelekaaeleaLgrirhpnllsLvGyCiageerllvyeflengnlqrlLhelpageqdvedwsadtWeeeeeekkse.......easWrirhrialGvaraLafLhhgcspeivhrdvkasnilldsele 221.0 1.1e-67 RLK-Pelle_LRR-VII-2 152 Cluster-605.0-0R PF07714.14 9 147 29 137 VHVAVKVLVLGSTMS-DQEAAREFEYLGRIKHPNLVPLTGYCLAGDQRIAIYEYMENGNLQHFLHDLplgiqttedwttdtweeeddnngiqnvgMKGSLITWRFRHKIALGTARALAFLHHGCsppIIHKDVKASSVYL v+vavK+l ++t + +e +e + + ++khpn+v l g c+ +++ + + ey+e+G+L++fL++ + + +t + ++al A+++++L++ ++H+d+ a v l vkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk............................eekekltlkdllsfalqiAkGmeyLeskk...lvHrdlaarNvLl 56.6 1.6e-17 Protein tyrosine kinase 152 Cluster-605.0-0R PF00069.22 9 148 25 132 VHVAVKVLVLGSTMSDQE--AAREFEYLGRIKHPNLVPLTGYCLAGDQRIAIYEYMENGNLQHFLHdlplgiqttE------DwttdtweeeddnngiqnvgmkgslitwrFRHKIALGTARALAFLHHGCsppIIHKDVKASSVYLD +vAvK++ ++ +++e ++rE ++l ++khpn+v l +++ d+++ + ey+e+g+l+++l+ + + kia ++++l++lH+ + iiH+D+K + + +d kivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls.........rkgslsee............................eakkiakqilegleylHskg...iiHrDlKpeNiLid 42.6 3e-13 Protein kinase domain 152 Cluster-6085.0-2R RLK-Pelle_RLCK-VIIa-2 6 252 29 275 AQAVAVKLLDIEGLQGHREWLAEVIFLGQLRHPNLVKLIGYCCEDEERLLVYEFMPRGSLENHLFKRLSISLPWGTRLKIAIGAAKGLAFLHGAEKPVIYRDFKTSNILLDSDFNAKLSDFGLAKMGPEGSNTHVTTRVMGTYGYAAPEYVNTGHLTTKSDIYSFGVVLLELLTGRRAMDKSRPKNEQNLVDWAKPYLISTRKLRCIVDPRLGGQYSVKGAKEMALLASQCVSLQPRDRPKMPAIIE +avavk l+ eglqgh+ewlaev fLgql+hpnlvkliGyc+ed+erllvyE+m++gslenhlf+r s +l+W trlkia+gaAkglafLh aek+viyRdfk+sniLld+dfnaklsdfglak+gpe+++thv+trvmgtygYaaPeyv+tGhlt+ksD+ysfGvvllelltGrra+dk+rpk+eq+lvdwa+p+l ++rkl+ i+Dprl gqys+k+a+++a la +C+s +p++Rpkm +++e glavavkklnkeglqghkewlaevefLgqlshpnlvkliGycledderllvyEymakgslenhlfrrssealsWetrlkialgaAkglafLheaekkviyRdfkasniLldedfnaklsdfglakegpeedkthvstrvmgtygYaaPeyvatGhltaksDvysfGvvllelltGrraldkkrpkeeqklvdwarpllsdkrkleriiDprlegqysakaaqkvaklalkClskepkeRpkmsevve 429.1 4.6e-131 RLK-Pelle_RLCK-VIIa-2 346 Cluster-6085.0-2R PF00069.22 6 251 24 259 AQAVAVKLLDIEGLQGHR--EWLAEVIFLGQLRHPNLVKLIGYCCEDEERLLVYEFMPRGSLENHLFKRLSisLPWGTRLKIAIGAAKGLAFLHgaEKPVIYRDFKTSNILLDSDFNAKLSDFGLAKMGPEGSNthvTTRVMGTYGYAAPEYVNTGHLTTKSDIYSFGVVLLELLTGRRAMDKSRPKN--EQNLVDWAKPYLISTrklrcIVDPR------LggqysvkgAKEMALLASQCVSLQPRDRPKMPAII + vAvK ++ e + + + l+E+ +l +l+hpn+v+l++++ e++e++lv e+++ g+l+++l ++ s l+ + kia ++gl++lH +k +i+rD K++NiL+d++ + K++DFGlak ++s+ +t ++gt Y APE +++ + ++k+D++s Gv+l+elltg+ + +++ k+ e++l + k + i + ++ l +e+ l +++++ +p++R+ + ++ gkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgs..lseeeakkiakqilegleylH..skgiiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.....etkeklpeasel........seeakdllkkllkkdpkkRltaeell 142.3 1.2e-43 Protein kinase domain 346 Cluster-6085.0-2R PF07714.14 6 254 28 260 AQAVAVKLLDIEGLQG-HREWLAEVIFLGQLRHPNLVKLIGYCCEDEERLLVYEFMPRGSLENHLFKR-LSISLPWGTRLKIAIGAAKGLAFLHgaEKPVIYRDFKTSNILLDSDFNAKLSDFGLAKMGPEGSNTHVTTRVMGTYGYAAPEYVNTGHLTTKSDIYSFGVVLLELLT-GRRAmdksrpkneqnlvdwaKPYLISTRKLRCIvDPRLGGQYSVKGAKEMALLASQCVSLQPRDRPKMPAIIETL + vavK l+ e + ++e l e+ ++ +l+hpn+vkl+g c ++e+ l+v e+++ G+L+++L k+ + +l + l++a+ AkG+++L+ +k ++ rd + N+Ll+++ +k+sDfGLa+ + ++++++++ + + apE ++++++t+ksD++sfGv+l E++t g++ p l +++ l+ + + + + k +e++ l +qC++ +p++Rp++ +++e+l evkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLe..skklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep................ypglsneevlekl.kegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 136.7 5.4e-42 Protein tyrosine kinase 346 Cluster-6187.0-0R CAMK_AMPK 24 276 1 253 YKLGKTLGIGSFGKVKVAEHTLTGHKVAVKILNRRKIKNMDMEEKVRREIKILRLFMHPHIIRLYEVIETPTDIYVVMEYVKSGELFDYIVEKGRLQEDEARNFFQQIISGVEYCHRNMVVHRDLKPENLLLDSKSNVKIADFGLSNIMRDGHFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYLLLCGTLPFDDENIPNLFKKIKGGIYTLPSHLSASARDLIPRMLIVDPMKRITIPEIRMHPWF yklgktlgigsf+kvkvaeh+ltg+kva+kilnrrk+k+m++eekvrreikilrl++hphi+rlyevietp+diyvvmeyvksgelfdyivekgrl+edear++fqqiisgveychrnmvvhrdlkpenllldsk+nvkiadfglsn++rdg+flktscgspnyaapevisgklyagpevdvwscgvily llcgtlpfddeni+nlfkkik+giytlpshlsa+ardli+r+l+vdp+kriti+eir h+wf yklgktlgigsfakvkvaehvltgkkvaikilnrrklkameleekvrreikilrllahphivrlyevietpsdiyvvmeyvksgelfdyivekgrlkedearrlfqqiisgveychrnmvvhrdlkpenllldsklnvkiadfglsnvlrdgkflktscgspnyaapevisgklyagpevdvwscgvilyallcgtlpfddenisnlfkkikdgiytlpshlsaeardlisrllvvdplkritiaeirehrwf 526.0 8.2e-161 CAMK_AMPK 345 Cluster-6187.0-0R PF00069.22 24 276 1 264 YKLGKTLGIGSFGKVKVAEHTLTGHKVAVKILNRRKIKNMDMeEKVRREIKILRLFMHPHIIRLYEVIETPTDIYVVMEYVKSGELFDYIVEKGRLQEDEARNFFQQIISGVEYCHRNMVVHRDLKPENLLLDSKSNVKIADFGLSNIMRDGHFLKTSCGSPNYAAPEVISGKLYaGPEVDVWSCGVILYLLLCGTLPFDDENIPNLFKKIKGG-------------IYTLPSHLSASARDLIPRMLIVDPMKRITIPEIRMHPWF y+ ++lG GsfGkV a ++ tg++vAvK+++++k+k+++ +kv+rEikil+ + hp+i+rlyev+e+++++y+v+eyv+ gel+d++ +kg l+e+ea+++++qi++g+ey+H++ ++HrDlKpeN+L+d+k+++Ki+DFGl++ ++ ++ l++ +g+++Y APEv++++ y +++vDvWs+Gvily ll+g+ pf +e+ + ++k+ + +s+ls +a+dl+ ++l +dp+kR+t+ e+ hp++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtreYlAPEvlkeney.skkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 270.4 1e-82 Protein kinase domain 345 Cluster-6187.0-0R PF07714.14 25 271 2 257 KLGKTLGIGSFGKVKVAEHT----LTGHKVAVKILNRRKikNMDMEEKVRREIKILRLFMHPHIIRLYEVIETPTDIYVVMEYVKSGELFDYIVEK---GRLQEDEARNFFQQIISGVEYCHRNMVVHRDLKPENLLLDSKSNVKIADFGLSNIM-RDGHF-LKTSC-GSPNYAAPEVISGKLYAgPEVDVWSCGVILYLLLC-GTLPFDDENIPNLFKKIKGG-IYTLPSHLSASARDLIPRMLIVDPMKRITIPEIR +lgk+lG G+fG+V ++ + + kvavK+l++++ + + +e++ +e+ki++ + hp+i++l+ v+ +++v+eyv++G+L +++ +k +l+ ++ +f +qi +G+ey +++ +vHrdl N Ll++++ vki+DfGL++ + +d + k+++ + ++ apE+++ k + + DvWs Gv+l+ +++ g p+ + + ++++k+k g + p++ +++ +l+ + + dp +R t+ e++ elgkklGeGafGeVvegtlkgekekkevkvavKtlkeea..teeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkft.sksDvWsfGvllwEiftlgeepypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelv 146.3 6.4e-45 Protein tyrosine kinase 345 Cluster-6236.0-0R CAMK_AMPK 24 191 1 168 YKLGKTLGIGSFGKVKVAEHTLTGHKVAVKILNRRKIKNMDMEEKVRREIKILRLFMHPHIIRLYEVIETPTDIYVVMEYVKSGELFDYIVEKGRLQEDEARNFFQQIISGVEYCHRNMVVHRDLKPENLLLDSKSNVKIADFGLSNIMRDGHFLKTSCGSPNYAAPE yklgktlgigsf+kvkvaeh+ltg+kva+kilnrrk+k+m++eekvrreikilrl++hphi+rlyevietp+diyvvmeyvksgelfdyivekgrl+edear++fqqiisgveychrnmvvhrdlkpenllldsk+nvkiadfglsn++rdg+flktscgspnyaape yklgktlgigsfakvkvaehvltgkkvaikilnrrklkameleekvrreikilrllahphivrlyevietpsdiyvvmeyvksgelfdyivekgrlkedearrlfqqiisgveychrnmvvhrdlkpenllldsklnvkiadfglsnvlrdgkflktscgspnyaape 343.4 4.5e-105 CAMK_AMPK 259 Cluster-6236.0-0R PF00069.22 24 191 1 167 YKLGKTLGIGSFGKVKVAEHTLTGHKVAVKILNRRKIKNMDMeEKVRREIKILRLFMHPHIIRLYEVIETPTDIYVVMEYVKSGELFDYIVEKGRLQEDEARNFFQQIISGVEYCHRNMVVHRDLKPENLLLDSKSNVKIADFGLSNIMRDGHFLKTSCGSPNYAAPE y+ ++lG GsfGkV a ++ tg++vAvK+++++k+k+++ +kv+rEikil+ + hp+i+rlyev+e+++++y+v+eyv+ gel+d++ +kg l+e+ea+++++qi++g+ey+H++ ++HrDlKpeN+L+d+k+++Ki+DFGl++ ++ ++ l++ +g+++Y APE yekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtreYlAPE 194.6 1.3e-59 Protein kinase domain 259 Cluster-6236.0-0R PF07714.14 25 177 2 160 KLGKTLGIGSFGKVKVAEHT----LTGHKVAVKILNRRKikNMDMEEKVRREIKILRLFMHPHIIRLYEVIETPTDIYVVMEYVKSGELFDYIVEK---GRLQEDEARNFFQQIISGVEYCHRNMVVHRDLKPENLLLDSKSNVKIADFGLSNIM-RDGHF +lgk+lG G+fG+V ++ + + kvavK+l++++ + + +e++ +e+ki++ + hp+i++l+ v+ +++v+eyv++G+L +++ +k +l+ ++ +f +qi +G+ey +++ +vHrdl N Ll++++ vki+DfGL++ + +d + elgkklGeGafGeVvegtlkgekekkevkvavKtlkeea..teeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddey 117.4 4.2e-36 Protein tyrosine kinase 259 Cluster-6236.0-2R CAMK_AMPK 191 259 177 245 GPEVDVWSCGVILYLLLCGTLPFDDENIPNLFKKIKGGIYTLPSHLSASARDLIPRMLIVDPMKRITIP gpevdvwscgvily llcgtlpfddeni+nlfkkik+giytlpshlsa+ardli+r+l+vdp+kriti+ gpevdvwscgvilyallcgtlpfddenisnlfkkikdgiytlpshlsaeardlisrllvvdplkritia 128.8 1.4e-39 CAMK_AMPK 259 Cluster-6236.0-2R PF00069.22 190 258 174 255 RGPEVDVWSCGVILYLLLCGTLPFDDENIPNLFKKIKGG-------------IYTLPSHLSASARDLIPRMLIVDPMKRITI +++vDvWs+Gvily ll+g+ pf +e+ + ++k+ + +s+ls +a+dl+ ++l +dp+kR+t+ yskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRlta 40.3 1.5e-12 Protein kinase domain 259 Cluster-6236.1-0R CAMK_AMPK 24 276 1 253 YKLGKTLGIGSFGKVKVAEHTLTGHKVAVKILNRRKIKNMDMEEKVRREIKILRLFMHPHIIRLYEVIETPTDIYVVMEYVKSGELFDYIVEKGRLQEDEARNFFQQIISGVEYCHRNMVVHRDLKPENLLLDSKSNVKIADFGLSNSMRDGHFRKTGCGIPNYAAPEVISGKLYAGPEVDVWSCGVILYLLLCGTLPFDDENIHNLLMKIKGGIYTLPSDLSAGARNLIPRMLTVDPMKRITIPEIRMHPWF yklgktlgigsf+kvkvaeh+ltg+kva+kilnrrk+k+m++eekvrreikilrl++hphi+rlyevietp+diyvvmeyvksgelfdyivekgrl+edear++fqqiisgveychrnmvvhrdlkpenllldsk+nvkiadfglsn +rdg+f kt cg pnyaapevisgklyagpevdvwscgvily llcgtlpfddeni nl kik+giytlps lsa ar+li+r+l+vdp+kriti+eir h+wf yklgktlgigsfakvkvaehvltgkkvaikilnrrklkameleekvrreikilrllahphivrlyevietpsdiyvvmeyvksgelfdyivekgrlkedearrlfqqiisgveychrnmvvhrdlkpenllldsklnvkiadfglsnvlrdgkflktscgspnyaapevisgklyagpevdvwscgvilyallcgtlpfddenisnlfkkikdgiytlpshlsaeardlisrllvvdplkritiaeirehrwf 499.4 1e-152 CAMK_AMPK 345 Cluster-6236.1-0R PF00069.22 24 276 1 264 YKLGKTLGIGSFGKVKVAEHTLTGHKVAVKILNRRKIKNMDMeEKVRREIKILRLFMHPHIIRLYEVIETPTDIYVVMEYVKSGELFDYIVEKGRLQEDEARNFFQQIISGVEYCHRNMVVHRDLKPENLLLDSKSNVKIADFGLSNSMRDGHFRKTGCGIPNYAAPEVISGKLYaGPEVDVWSCGVILYLLLCGTLPFD----DE----NIHN--LLMKIKG---GIYTLPSDLSAGARNLIPRMLTVDPMKRITIPEIRMHPWF y+ ++lG GsfGkV a ++ tg++vAvK+++++k+k+++ +kv+rEikil+ + hp+i+rlyev+e+++++y+v+eyv+ gel+d++ +kg l+e+ea+++++qi++g+ey+H++ ++HrDlKpeN+L+d+k+++Ki+DFGl++ ++ ++ ++ +g ++Y APEv++++ y +++vDvWs+Gvily ll+g+ pf +e ++++ ++ki g + +s+ls a++l+ ++l++dp+kR+t+ e+ hp++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtreYlAPEvlkeney.skkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 266.2 1.9e-81 Protein kinase domain 345 Cluster-6236.1-0R PF07714.14 25 271 2 257 KLGKTLGIGSFGKVKVAEHT----LTGHKVAVKILNRRKikNMDMEEKVRREIKILRLFMHPHIIRLYEVIETPTDIYVVMEYVKSGELFDYIVEK---GRLQEDEARNFFQQIISGVEYCHRNMVVHRDLKPENLLLDSKSNVKIADFGLSNSM--RDGHFRKTGCGIP-NYAAPEVISGKLYAgPEVDVWSCGVILYLLLC-GTLPFDDENIHNLLMKIKGG-IYTLPSDLSAGARNLIPRMLTVDPMKRITIPEIR +lgk+lG G+fG+V ++ + + kvavK+l++++ + + +e++ +e+ki++ + hp+i++l+ v+ +++v+eyv++G+L +++ +k +l+ ++ +f +qi +G+ey +++ +vHrdl N Ll++++ vki+DfGL++++ +d +k+++ +p ++ apE+++ k + + DvWs Gv+l+ +++ g p+ + + +++l k+k g + p++ ++ +l+ + ++ dp +R t+ e++ elgkklGeGafGeVvegtlkgekekkevkvavKtlkeea..teeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkft.sksDvWsfGvllwEiftlgeepypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelv 148.1 1.8e-45 Protein tyrosine kinase 345 Cluster-6239.0-1R TKL-Pl-4 23 159 4 118 LVAQGTYGTVYRGTYDNQDVAVKLLDWGedgMATATETAALRASFKQEVAVWHKLDHPNVTRFVGASMgtsqlkipsknpsdgysnlPSRACCVLVEFLQGGTLKNFLYKNRKKKLAYKIVIQLALDLSRGLSYLHS +a+G++g++y+g+y++qdvavK+l++g ++++e+a+l+++fkqevav++kl+H+nv++f+ga++ ++a+c+++e+l+gg+lk++l k++kkkl++k v++lald++rgl+ylhs kiaeGalgklykgkykeqdvavKileag...eekeeeaaelekefkqevavlsklkHknvvkfigact...................kepalcivteylkggslkkylekkkkkklklkvvvklaldiargleylhs 138.9 1.8e-42 TKL-Pl-4 159 Cluster-6239.0-1R PF07714.14 21 159 4 122 RYLVAQGTYGTVYRGTYD------NQDVAVKLLDwgedgmATATETAalRASFKQEVAVWHKLDHPNVTRFVGASMgtsqL--KipsknpsdgysnlpsraCCVLVEFLQGGTLKNFLYKN-RKKKLAYKIVIQLALDLSRGLSYLHS +++G++G+V++gt++ +++vavK l+ ++ate++ +++f +e+++ +kl+hpn+ +++g+ + + ++++e+++gG+L++fL k+ +k+kl +k ++++al++++G++yL+s gkklGeGafGeVvegtlkgekekkevkvavKtlk......eeateee..keefleeakimkklkhpnivkllgvct....keep.................llivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLes 55.7 2.9e-17 Protein tyrosine kinase 159 Cluster-6239.0-1R PF00069.22 25 159 8 116 AQGTYGTVYRGT--YDNQDVAVKLLDWGEDGMATAtetaalrASFKQEVAVWHKLDHPNVTRFVGASMGtsqlkipsknpsdgysnlpSRACCVLVEFLQGGTLKNFLYknRKKKLAYKIVIQLALDLSRGLSYLHS +G++G+Vy+++ +++ vAvK ++ ++ + ++ +E+++ +kl+hpn+ r++++ ++ ++++e+++gg+l+++l rk++l+ + + ++a + +gl+ylHs GeGsfGkVykaveketgkivAvKkikkekakkkke.......kkvlrEikilkklkhpnivrlyevfee...................kdelylvleyveggeladlls..rkgslseeeakkiakqilegleylHs 41.8 5.2e-13 Protein kinase domain 159 Cluster-6245.0-2R RLK-Pelle_LRR-XIIIa 1 87 180 267 KGDVYSFGVVLLELLTGKKPTDEAFIEEGTKLVTWVKTVVDEKREEHVLDSSL-EDFPVDEVNAAFNIALMCLESEPHNRPTMAEVLK kgdvysfGvvllell+gk+ptde ++e+g++lv+wvk++v+e+ree+++d+sl e+++ +e++a+++ial+c+++ep++rptm++v+k kgdvysfGvvllellsgkrptdesllekglnlvewvkalvkenreeeivdkslleevekeeleavleialkcvsaepeerptmdkvvk 99.8 1.4e-30 RLK-Pelle_LRR-XIIIa 284 Cluster-6245.0-2R PF07714.14 2 89 187 260 GDVYSFGVVLLELLT-GKKPtdeafieegtklvtwVKTVVDEKREEHVLDSSLEDFPVDEVNAAFNIALMCLESEPHNRPTMAEVLKML Dv+sfGv+l E++t g++p ++++ +e+ e++ ++ + p + ++ ++ C+e++p++Rpt++e+++ l sDvWsfGvllwEiftlgeep...............ypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 27.1 1.5e-08 Protein tyrosine kinase 284 Cluster-6245.1-2R RLK-Pelle_LRR-XIIIa 1 87 180 267 KGDVYSFGVVLLELLTGKKPTDEAFIEEGTKLVTWVKTVVDEKREEHVLDSSL-EDFPVDEVNAAFNIALMCLESEPHNRPTMAEVLK kgdvysfGvvllell+gk+ptde ++e+g++lv+wvk++v+e+ree+++d+sl e+++ +e++a+++ial+c+++ep++rptm++v+k kgdvysfGvvllellsgkrptdesllekglnlvewvkalvkenreeeivdkslleevekeeleavleialkcvsaepeerptmdkvvk 100.5 8.3e-31 RLK-Pelle_LRR-XIIIa 224 Cluster-6245.1-2R PF07714.14 2 89 187 260 GDVYSFGVVLLELLT-GKKPtdeafieegtklvtwVKTVVDEKREEHVLDSSLEDFPVDEVNAAFNIALMCLESEPHNRPTMAEVLKML Dv+sfGv+l E++t g++p ++++ +e+ e++ ++ + p + ++ ++ C+e++p++Rpt++e+++ l sDvWsfGvllwEiftlgeep...............ypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 27.8 9.3e-09 Protein tyrosine kinase 224 Cluster-6344.0-1R CAMK_CDPK 8 267 1 259 YQLCEELGRGRFGVVYRCYSPFSGEYFACKSIDKNSLSdDATDRECLDKEPKILQLLSGSPNILQLYKIYEDDEYLHMVTDLCDGGDLYDRVSVGTPFGEPEAAAILKQLMVAISCCHRLGISHRDIKPDNILFDSA---GRLKLADFGSAEWFGVSEDglMTGVVGTPYYVAPEVLmGIEYNEKVDVWSAGVILYIMLSGVPPFYGEGPAETFQAVLRGNLRFPTRIFRSISPEAKDLLRKMICRDASRRLSADQVLRHPWI y+l++elGrG+fGvv+++++ +ge +A+Ksi+k++ls +a+d+e++ +e kil+ lsg++n+ ql+++yed++ +h+v++lc+gg+l+dr+ + e +aa++++q++ +++ cH+ g+ hrD+KP+N+l++s+ +lk++DFG++ ++ +e ++++vG+pyyvaPEvl +y++++dvWsaGvilyi+l+gvppf++e +e f+avl+++l+f ++ ++s+s+eakdl+r+++++d ++Rl+a+qvL+hpW+ yelgkelGrGefGvvrlatekatgeevAvKsiskrkls.kaedvedvrrevkilkhlsghknvvqlkgayedkdsvhlvmelceggelldrilargkyseraaakvvrqilevvaacHskgvvhrDlKPeNflltskeedaplkaiDFGlsvfvkeger..ledivGspyyvaPEvl.krsygkeadvWsaGvilyillcgvppfwaeteeeifkavlkaeldfksepwksvseeakdlvrrlLekdpkkRltaeqvLehpWl 305.6 2.3e-93 CAMK_CDPK 392 Cluster-6344.0-1R PF00069.22 8 267 1 264 YQLCEELGRGRFGVVYRCYSPFSGEYFACKSIDKNSLSDDATdrECLDKEPKILQLLSgSPNILQLYKIYEDDEYLHMVTDLCDGGDLYDRVSVGTPFGEPEAAAILKQLMVAISCCHRLGISHRDIKPDNILFDSAGRLKLADFGSAEWFGVSEDglMTGVVGTPYYVAPEVLMGIEYNEKVDVWSAGVILYIMLSGVPPFYGEGPAETFQAVLRG---------NLRFPTRIFRSISPEAKDLLRKMICRDASRRLSADQVLRHPWI y+ e+lG+G fG+Vy++++ +g+ +A+K i+k++ +++ + + + +E kil+ l+ +pni++ly+++e++++l++v+++++gg+l d++s + + e ea i+kq++ +++ +H+ gi HrD+Kp+NiL+d+ g lK++DFG a+ + s++ +t +vgt++Y+APEvl + ey +kvDvWs+Gvily +l+g ppf+ge e++++ l+ + ++ ++ +++s+eakdll+k++++d ++Rl+a+++l+hp++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkke..kkvlrEikilkklk.hpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 229.7 2.6e-70 Protein kinase domain 392 Cluster-6344.0-1R PF07714.14 10 262 3 257 LCEELGRGRFGVVYRCYSP----FSGEYFACKSIDKNSLSDDatdRECLDKEPKILQLLsGSPNILQLYKIYEDDEYLHMVTDLCDGGDLYDRVSVG---TPFGEPEAAAILKQLMVAISCCHRLGISHRDIKPDNILFDSAGRLKLADFGSAEWFGVSED-GLMTGVVGTPYYVAPEVLMGIEYNEKVDVWSAGVILYIMLS-GVPPFYGEGPAETFQAVlRGNLRFPTRifRSISPEAKDLLRKMICRDASRRLSADQVL l ++lG+G+fG V++++ + a K++++++ +++ +e + +e ki++ l pni++l+ ++ ++e l +vt++++gGdL + + +++ + + +q+ +++ ++ + Hrd+ N+L ++ k++DfG a+ +++ ++ ++apE+l+ ++++k DvWs Gv+l+ +++ g p+ g ++e+++++ + + r ++ +++++e ++l+++ + +d+++R + ++++ lgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateee...keefleeakimkkl.khpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevlekl.kegkrlekp..ekcpeelyelmkqCweedpeeRptfkelv 92.1 2.2e-28 Protein tyrosine kinase 392 Cluster-6396.0-1F STE_STE11 36 296 2 255 RGERLGLGSFGTVNLAVPRKQSsqitPLMAVKSCGASKATS-LMNEKLVLDELkDCPEIIRCFGESFSFENAEkLYNVLLEYAPGGNLADKLKNSGDRrLPESQVRCYTKALIKGLEYIHKLGYVHCDIKLQNILLCENGGVKIADFGLAKRVGGEEEGgsSGCELRGTPLYMSPEMVAGGKQGTPADIWALGCVVAEMVTGTPVWRG-SDLAALLMRIGVSEEVPEIPENLSGDGKDFLEKCFLKDPHKRWTAEMLLNHPFV +ge lG g+fg+V+la+ +++ l+avks+ +++a+s L++E +l++L ++p+i+r++g++++ e+ e +n+llEy++gg+la+ lk++g++ l+es+vr yt+ +++GLey+H+ g+vH+Dik +Nil+ +ng vk+aDFGlak+v+ ee+ + +++gtplym+pe++ ++++g+ aDiw+lGC+V em+tg ++w ++ a l++ig s+e+Peipe+ls ++kdFl+kC+ +dp++R+ta++LL+hpF+ kgellGegafgsVylalnkesg....ellavksvelesaksaLekEikllskL.khpnivrylgseveeekse.elnillEyvsggslasllkrlggk.lseslvrkytrqileGLeylHskgivHrDikgaNilvdsngevklaDFGlakeveeeesl..asksvkgtplymapevirkeelglaaDiwslGCtVlemltgkapwseleeevaalfkigkskelPeipeslseeakdFlskClqrdpaeRptaaeLLehpFl 291.9 3.6e-89 STE_STE11 444 Cluster-6396.0-1F PF00069.22 36 296 3 264 RGERLGLGSFGTVNLAVPRKQSSQitplMAVKSCGASKAT-----SLMNEKLVLDELKdCPEIIRCFGesfSFENAEKLYnVLLEYAPGGNLADKLKnsGDRRLPESQVRCYTKALIKGLEYIHKLGYVHCDIKLQNILLCENGGVKIADFGLAKRVGGEEEggssGCELRGTPLYMSPEMVAGGKQGTPADIWALGCVVAEMVTGTPVWR---GSD-LAALLMR-------IGVSEEVPEIPENLSGDGKDFLEKCFLKDPHKRWTAEMLLNHPFV + e+lG GsfG+V av ++++ + +AvK +ka+ ++++E +l +lk +p+i+r+++ +fe+ ++ly ++ley++gg+lad l+ + l+e++++ ++k +++gley+H+ g +H+D+K +NiL+ e+g +Ki+DFGlak++ +++ + gt+ Y++PE++ + + ++++D+W+lG++++e++tg+p+++ g++ ++ l++ +g ++e + +++ls + kd+l+k++ kdp+kR+tae+ll+hp++ kleklGeGsfGkVykaveketgki....vAvKkikkekakkkkekkvlrEikilkklk.hpnivrlye...vfeekdely.lvleyveggeladlls..rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk....ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 184.4 1.7e-56 Protein kinase domain 444 Cluster-6396.0-1F PF07714.14 37 291 4 257 GERLGLGSFGTVNLAVPRKQSSQITPLMAVKSC--GASK--ATSLMNEKLVLDELkDCPEIIRCFGESFsfeNAEKlYNVLLEYAPGGNLADKLKNS-GDRRLPESQVRCYTKALIKGLEYIHKLGYVHCDIKLQNILLCENGGVKIADFGLAKRVGGEEEGgSSGCELRGTPLYMSPEMVAGGKQGTPADIWALGCVVAEMVT-GTPVWRGSDLAALLMRIgVSEEVPEIPENLSGDGKDFLEKCFLKDPHKRWTAEMLL g++lG G+fG+V + ++++++ + avK++ +a++ +++++e ++ +l + p+i+++ g ++e+ + +++ey++gG+L + L+++ +++l +++ ++++ + kG+ey+++ +vH d+ +N+Ll+en vki+DfGLa+++ ++e ++ e + +m+pE++ +k + +D+W+ G ++ E++t g ++g + + +l ++ +++ e pe+ + + ++++++C+ +dp++R t + l+ gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkkl.khpnivkllgvct...keep.llivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddey.kkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevlekl.kegkrlekpekcpeelyelmkqCweedpeeRptfkelv 123.1 7.9e-38 Protein tyrosine kinase 444 Cluster-6450.0-2F CMGC_MAPK 17 128 177 288 FEEYTPAVDIWSIGCIFAEVLTGKPLFPGKSVVHQLDLITDLLGTPSADTISGVRNEKSRKYLTDMLNKHPVSFAEKFPTADPLAVKLLKRLLSFDPKDRPTAEEALADPYF +++Yt+a+D+Ws+GCifae+lt+kplfpgk+vv+ql+lit+l+Gtps+++++ vr+ek r+yl+++ +k+++s+++kfp++d+la++Ll+rll+fdPk+r+taeeala+py+ sskYtsaiDvWsvGCifaelltrkplfpgkdvvdqlkliteliGtpseedlesvrsekarrylkklpkkakkslkkkfpkvdelaldLlerllafdPkkritaeealahpyl 151.9 1.6e-46 CMGC_MAPK 457 Cluster-6450.0-2F PF00069.22 18 128 172 264 EEYTPAVDIWSIGCIFAEVLTGKPLFP---GKS----VVHQLDLITDLLGtpsadtisG----------VrneksrkyltdmlnkhpvsfaekfptaDPLAVKLLKRLLSFDPKDRPTAEEALADPYF +ey+++vD+Ws+G+i++e+ltgkp+f+ gk+ ++ql i+++lg + ++ a +llk+ll+ dpk+R+taee+l++py+ neyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg........etkeklpeasel...........................seeakdllkkllkkdpkkRltaeellqhpyl 54.8 5.7e-17 Protein kinase domain 457 Cluster-649.0-2F Group-Pl-3 66 130 3 67 RSKLGESSLATVWEAENRTTRQVVALKQIHVTKLTRRLKNCLECELTFLSSVNHPNIIRLLDVIE ++g s+a+vw+a++++t + va+k+i++++l ++l+++le+e+++l++++hpniirlld+ie teqigsgsfavvwkakhkstgeevavkeialerlnkklresleseiailrridhpniirlldlie 62.8 2e-19 Group-Pl-3 158 Cluster-649.0-2F PF00069.22 63 131 1 69 YVLRSKLGESSLATVWEAENRTTRQVVALKQIHVTKLTRRLKNCLECELTFLSSVNHPNIIRLLDVIEV y +klGe s ++V +a +++t++ vA+K+i + k + + ++ + E+++l +++hpni+rl++v+e yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee 35.6 4.1e-11 Protein kinase domain 158 Cluster-649.0-2F PF07714.14 65 130 3 71 LRSKLGESSLATVWEAENR----TTRQVVALKQIHVTKLTRRLKNCLEcELTFLSSVNHPNIIRLLDVIE l +klGe + ++V+e++ + ++++ va+K+++ ++ ++ ++ le e++++++++hpni++ll v+ lgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefle.eakimkklkhpnivkllgvct 22.1 5.2e-07 Protein tyrosine kinase 158 Cluster-6705.4-0R RLK-Pelle_RLCK-V 10 276 1 267 DNVIGEGGYGIVYHGQLINGTTVAVKKLLNNLGQAEKEFRVEVEAIGHVRHKNLVRLLGYCIEGTHRMLVYEYVNNGNLEQWLHGAMRHHGFLTWEARMKVLTGTAKALAYLHEAIEPKVVHRDIKSSNILIDENFDAKISDFGLAKLLGAGKSHITTRVMGTFGYVAPEYANTGFLNEKSDVYSFGVVLLEAITGRDPVDYGRAAHEVNLVDWLKMMVGNRRSEEVVDPNIDRRPSTRGLKKALLTALRCVDPDSDKRPRMSQVVR +nvigeGgyg+vy+g+l++gt+vavkkllnn gqaekef+veveaig+vrhknlvrllGyc+eg++r+lvyeyv+ngnleqwlhG++++++ ltwearmk+++gtakalaylhea+epkvvhrdikssnil+d++f+ak+sdfGlakllg++ks++ttrvmgtfgyvapeyantg+lneksdvysfgv+lle+itgrdpvdy r+a+evnlv+wlk+mv++rr+eevvdp+++++ps+r lk+all+alrcvdpd++krp+m+qvv+ envigeGgygvvyrgkladgtevavkkllnnkgqaekefkveveaigkvrhknlvrllGycvegaerllvyeyvdngnleqwlhGdvseksaltwearmkiilgtakalaylhealepkvvhrdikssnilldkefnakvsdfGlakllgseksyvttrvmgtfgyvapeyantgllneksdvysfgvllleiitgrdpvdysrpaeevnlvewlklmvaerraeevvdpkleekpssralkrallvalrcvdpdaekrpkmgqvvk 520.0 7e-159 RLK-Pelle_RLCK-V 419 Cluster-6705.4-0R PF00069.22 8 276 2 260 SKDNVIGEGGYGIVYHGQ-LINGTTVAVKKLLNNLGQAEKE--FRVEVEAIGHVRHKNLVRLLGYCIEGTHRMLVYEYVNNGNLEQWLHgamrHHGFLTWEARMKVLTGTAKALAYLHEAIepkVVHRDIKSSNILIDENFDAKISDFGLAKLLGAGKShiTTRVMGTFGYVAPEYANTGFLNEKSDVYSFGVVLLEAITGRDPVD--YGRAAHEVNLVDwLK---MMVGnrrseeVVDPN------IdrrpstrgLKKALLTALRCVDPDSDKRPRMSQVVR +k++ +GeG++G Vy + +g +vAvKk+ ++ + +ke ++ E++ + +++h+n+vrl++++ e ++++lv eyv++g+l+++l+ ++g l+ e k+++ ++++l+ylH++ ++HrD+K++NiLide+ + Ki+DFGlak l +++ +t ++gt Y+APE ++ +k+Dv+s Gv+l+e +tg+ p g+ +e +l + l+ +++g ++ + + ++a+ ++++ d kR+ ++++++ ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls....rkgslseeeakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldq.lekilkilg......etkeklpeasel........seeakdllkkllkkdpkkRltaeellq 165.3 1.1e-50 Protein kinase domain 419 Cluster-6705.4-0R PF07714.14 10 278 4 260 DNVIGEGGYGIVYHGQLI-----NGTTVAVKKLLNNLGQA-EKEFRVEVEAIGHVRHKNLVRLLGYCIEGTHRMLVYEYVNNGNLEQWLHGAmRHHGFLTWEARMKVLTGTAKALAYLHEAiepKVVHRDIKSSNILIDENFDAKISDFGLAKLL-GAGKSHITTRVMGTFGYVAPEYANTGFLNEKSDVYSFGVVLLEAIT-GRDPvdygraahevnlvdwLKMMVGNRRSEEVVDPNidRRPSTRGLKKALLT-ALRCVDPDSDKRPRMSQVVRML ++ +GeG +G V++g+l + ++vavK+l ++ + ++ef e++ + +++h+n+v+llg c+++ + ++v eyv++G+L++ L+ +++ lt + +++ + Ak+++yL++ k+vHrd+ + N+L++en +kisDfGLa+ + + + +++ + ++apE +++ +++ksDv+sfGv+l E +t g++p ++ + ++ e + + + r + + +++l + +C++ d+++Rp+++++v+ l gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk.eekekltlkdllsfalqiAkGmeyLesk...klvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep...............ypglsneevleklkegk..rlekpekcpeelyelmkqCweedpeeRptfkelvekl 155.7 8.7e-48 Protein tyrosine kinase 419 Cluster-6792.0-1F RLK-Pelle_RLCK-VIIa-2 1 99 177 275 EYVMTGHLTARSDVYSFGVVLLELLTGRKSVDKTRPSREQSLVDWARPKLNDKRKMLQIIDPRLENQYSVRAAQKACSLAYYCLSQNPKARPLMSDVVE eyv+tGhlta+sDvysfGvvllelltGr+++dk+rp++eq+lvdwarp l+dkrk+ +iiDprle+qys++aaqk+++la+ Cls++pk+Rp ms+vve eyvatGhltaksDvysfGvvllelltGrraldkkrpkeeqklvdwarpllsdkrkleriiDprlegqysakaaqkvaklalkClskepkeRpkmsevve 147.7 3e-45 RLK-Pelle_RLCK-VIIa-2 203 Cluster-6792.0-1F PF07714.14 1 101 176 260 EYVMTGHLTARSDVYSFGVVLLELLT-GRKSvdktrpsreqslvdwaRPKLnDKRKMLQIIDPRLENQYSVRAAQKACSLAYYCLSQNPKARPLMSDVVETL E ++++++t +sDv+sfGv+l E++t g+++ p+l +++++l+ ++ + + + + ++ +l C++++p+ Rp ++++ve+l EslkekkftsksDvWsfGvllwEiftlgeep................ypgl.sneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 30.8 1.1e-09 Protein tyrosine kinase 203 Cluster-6792.0-1F PF00069.22 5 99 171 260 TGHLTARSDVYSFGVVLLELLTGRKSVDKTRPSREQS-LVDWarpkLNDKRKMLQIIDPRLENQYSVraAQKACSLAYYCLSQNPKARPLMSDVVE + + ++ +Dv+s Gv+l+elltg+ +++ + +++ +d l +k+l+ + l++++++ ++a +l +l+++pk R+ ++++++ eneyskkvDvWslGvilyelltgkppfsgekgkekvekeldq....lekilkilgetkeklpeasel..seeakdllkkllkkdpkkRltaeellq 27.3 1.4e-08 Protein kinase domain 203 Cluster-681.0-0F TKL-Pl-3 30 117 2 89 LVSPIARGAESVVWEAMLDGRKVAVKKPILSTSDDLNKFHKELKLLCKLDHAGISKLLAVHARPPNYMFFFKFYEGGNLAQKLHIDEW l+s+ia+Gaesvv+ea+l+G++va+kkp+lstsddl+kf++el+ll++l+h ++ klla +a+pp+y++++++ye g+la++lh++ew llskiakGaesvvyearleGkavaakkprlstsddldkfktelqllaelkhpavakllaarakppdylllldlyeagtlaealhveew 130.1 7.7e-40 TKL-Pl-3 117 Cluster-681.0-0F PF07714.14 32 113 5 93 SPIARGAESVVWEAMLD------GRKVAVKKPILSTSD-DLNKFHKELKLLCKLDHAGISKLLAVHARPPNYMFFFKFYEGGNLAQKLH + +++Ga + V+e+ l+ kvavK+ ++++ + ++f +e+k+++kl+h i kll+v + ++++ +++ egG+L + L+ kklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLr 31.5 6.8e-10 Protein tyrosine kinase 117 Cluster-681.0-0F PF00069.22 29 113 2 90 SLVSPIARGAESVVWEAM--LDGRKVAVKKPILSTSDDLNK--FHKELKLLCKLDHAGISKLLAVHARPPNYMFFFKFYEGGNLAQKLH + ++ + +G+ ++V +a+ +g++vAvKk + ++ ++ + +E+k+l kl+h i +l+ v ++ ++++++ + egg+la+ l+ ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls 28.9 4.7e-09 Protein kinase domain 117 Cluster-6838.0-2F CK1_CK1 1 207 30 236 KLESAKTKHPQLHYESKLYMLLQGGTGIPHLKWYGVEGEYNAMVIDLLGPSLEDLFNYCNRKFTLKTVLMLADQLITRVEYMHSRGFLHRDIKPDNFLMGLGRKASQVYIIDYGLAKKYRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYDKISEKKMLTPIEGLCKSY kles+ktkhpql+yeskly++lqggtgip+lkw+gveg+yn++v+dllgpsledlfnyc+rkf+lktvlmladqli+rvey+hs+gflhrdikpdnflmglgrka+qvyiid+glakkyrd +t+khipyrenknltgtaryasvnthlg+eqsrrddleslgyvl+yflrgslpwqglkagtkkqky+kisekk+ t+ie lcksy klesvktkhpqllyesklyrilqggtgipnlkwfgvegdynvlvldllgpsledlfnycsrkfslktvlmladqlinrveyvhskgflhrdikpdnflmglgrkanqvyiidfglakkyrdaktkkhipyrenknltgtaryasvnthlgieqsrrddleslgyvllyflrgslpwqglkagtkkqkyekisekkvstsievlcksy 425.7 3.3e-130 CK1_CK1 514 Cluster-6838.0-2F PF00069.22 39 190 71 212 EYNAMVIDLLG-PSLEDLFNyCNRKFTLKTVLMLADQLITRVEYMHSRGFLHRDIKPDNFLMGlgrKASQVYIIDYGLAKKYRDLQThkhipyreNKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAG-TKKQKYDK ++ +v++++ +l+dl + + +++ +++ +a q+++ +ey+Hs+g++HrD+Kp+N+L+ + +++ i+D+Glak+++ ++ ++ +gt +Y + + e s+ D+ slG +l+ +l g p++g k ++++++d+ delylvleyveggeladlls.rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLid...ekgelKitDFGlakelesssk........ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldq 63.7 1.1e-19 Protein kinase domain 514 Cluster-6838.0-2F PF07714.14 51 228 87 252 SLEDLFNYC--NRKFTLKTVLMLADQLITRVEYMHSRGFLHRDIKPDNFLMGlgrKASQVYIIDYGLAKKYRDLQTHkhipyRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLR-GSLPWQGLkagTKKQKYDKISEKKMLTPIeglcKSYPPEFISYFHYCRSLRFEDKPD +L++ + ++k+tlk++l +a q+ +ey++s+ ++Hrd+ N L+ + ++v i D+GLa++ ++ ++ +++++ + ++ ++ + + + + D s G +l+ + g+ p++gl ++++ ++k++e+k l+ ++ p+e+ + + C + + e+ p+ dLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLls...enkvvkisDfGLardiekddey.....kkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypgl...sneevleklkegkrlekp....ekcpeelyelmkqCweedpeeRpt 31.2 8.4e-10 Protein tyrosine kinase 514 Cluster-6998.0-1F AGC_RSK-2 254 589 1 258 RLLKKLGCGDIGSVYLSELCGTKCYFAMKVMDKASLASRKKLLRAQTEREILQSLDHPFLPTLYTHFETEKFSCLVMEFCPGGDLHTLRQRQPGKHFTEQAVKFYVAEVLLALEYLHMLGIVYRDLKPENVLVREDGHIMLSDFDLSLRCAVSptliksssqaeplsknsgycvqpaciepsciqpscmvptscftprlfsskskkdrktktdtpnqvsplpeliaepteaRSMSFVGTHEYLAPEIIKGEGHGSAVDWWTFGIFLYELLFGKTPFKGSGNRATLFNVVGQPLRFPESPVVSFAARDLIRGLLVKEPQHRLAYKRGATEIKQHPFF +llkklG+Gdigsvyl+el gt+++fa+kv+dk++la+rkkl ra++ereil++ldhPflptly++fetekf+clv+efcpggdLh+lr+rqp k+f+e+av+fy+aev+laleylh+lgivyrdLkPenvlvredGhiml+DfDLsl+++ + rs+sfvGt+eylaPeiikgeghgsavdWW++Gi+lyell+gktPfkg+ +++tl+nv+ ++l+fpe++ vs++ardlir+ll+k+p++rl++krga+eik+hpff kllkklGsGdigsvylvelrgtealfalkvldkealakrkklkraeaereilelldhPflptlyasfetekfvclvvefcpggdLhvlrerqpkkvfseeavrfyaaevvlaleylhalgivyrdLkPenvlvredGhimltDfDLslkasak..............................................................................rsnsfvGteeylaPeiikgeghgsavdWWalGillyellygktPfkgknreetlanvlkkelefpeeaavsleardlirkllekdpkkrlgskrgaaeikkhpff 441.6 6.7e-135 AGC_RSK-2 707 Cluster-6998.0-1F PF00069.22 254 403 2 148 RLLKKLGCGDIGSVYLSELCGTKCYFAMKVMDKASLASRKKlLRAQTEREILQSLDHPFLPTLYTHFETEKFSCLVMEFCPGGDLHTLRQrqPGKHFTEQAVKFYVAEVLLALEYLHMLGIVYRDLKPENVLVREDGHIMLSDFDLSLRC + l+klG G+ G+Vy t++ +A+K+++k + ++k+ ++++E +il++l+hp++ +ly fe+++ +lv+e+++gg+l++l + ++++e+ +k++++++l +leylH gi++rDlKpeN+L+ e+g+++++DF+l+ + ekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls..rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakel 127.5 3.7e-39 Protein kinase domain 707 Cluster-6998.0-1F PF00069.22 486 589 154 264 SMSFVGTHEYLAPEIIKGEGHGSAVDWWTFGIFLYELLFGKTPFKGSGNRATLFNVVGQ-----------PLRFPESPVVSFAARDLIRGLLVKEPQHRLAykrgATEIKQHPFF +sfvgt+eYlAPE++k+++++++vD+W+ G+ lyell+gk+pf+g+ ++ + + + q + +pe +s a+dl++ ll k+p++Rl a+e++qhp++ ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRlt....aeellqhpyl 72.9 1.7e-22 Protein kinase domain 707 Cluster-6998.0-1F PF07714.14 254 414 2 165 RLLKKLGCGDIGSVYLSELC----GTKCYFAMKVMDKASLASRkkLLRAQTEREILQSLDHPFLPTLYTHFETEKFSCLVMEFCPGGDLHT-LRQRQPGKHFTEQAVKFYVAEVLLALEYLHMLGIVYRDLKPENVLVREDGHIMLSDFDLSLRCAVSPTLIKSSS +l kklG G G+V+ +l +++ a+K++++ + +++ + +e +i+++l+hp + l+ e+ ++v+e+++gGdL++ Lr+++ +++t + + +++++ ++eyL+ +v rdl NvL++e+ ++ +sDf L+ + + + k+++ elgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateee..keefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkee 72.1 2.8e-22 Protein tyrosine kinase 707 Cluster-6998.0-1F PF07714.14 492 576 169 253 THEYLAPEIIKGEGHGSAVDWWTFGIFLYELLF-GKTPFKGSgNRATLFNVVGQPLRFPESPVVSFAARDLIRGLLVKEPQHRLAY +++apE++k + s+ D W fG+ l+E++ g++p++g + +++++ + + r ++ ++ + +l++ + ++p++R + pvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypgl.sneevleklkegkrlekpekcpeelyelmkqCweedpeeRptf 26.8 1.9e-08 Protein tyrosine kinase 707 Cluster-6998.2-1F AGC_RSK-2 235 570 1 258 RLLKKLGCGDIGSVYLSELCGTKCYFAMKVMDKASLASRKKLLRAQTEREILQSLDHPFLPTLYTHFETEKFSCLVMEFCPGGDLHTLRQRQPGKHFTEQAVKFYVAEVLLALEYLHMLGIVYRDLKPENVLVREDGHIMLSDFDLSLRCAVSptliksssqaeplsknsgycvqpaciepsciqpscmvptscftprlfsskskkdrktktdtpnqvsplpeliaepteaRSMSFVGTHEYLAPEIIKGEGHGSAVDWWTFGIFLYELLFGKTPFKGSGNRATLFNVVGQPLRFPESPVVSFAARDLIRGLLVKEPQHRLAYKRGATEIKQHPFF +llkklG+Gdigsvyl+el gt+++fa+kv+dk++la+rkkl ra++ereil++ldhPflptly++fetekf+clv+efcpggdLh+lr+rqp k+f+e+av+fy+aev+laleylh+lgivyrdLkPenvlvredGhiml+DfDLsl+++ + rs+sfvGt+eylaPeiikgeghgsavdWW++Gi+lyell+gktPfkg+ +++tl+nv+ ++l+fpe++ vs++ardlir+ll+k+p++rl++krga+eik+hpff kllkklGsGdigsvylvelrgtealfalkvldkealakrkklkraeaereilelldhPflptlyasfetekfvclvvefcpggdLhvlrerqpkkvfseeavrfyaaevvlaleylhalgivyrdLkPenvlvredGhimltDfDLslkasak..............................................................................rsnsfvGteeylaPeiikgeghgsavdWWalGillyellygktPfkgknreetlanvlkkelefpeeaavsleardlirkllekdpkkrlgskrgaaeikkhpff 441.7 6.3e-135 AGC_RSK-2 688 Cluster-6998.2-1F PF00069.22 235 384 2 148 RLLKKLGCGDIGSVYLSELCGTKCYFAMKVMDKASLASRKKlLRAQTEREILQSLDHPFLPTLYTHFETEKFSCLVMEFCPGGDLHTLRQrqPGKHFTEQAVKFYVAEVLLALEYLHMLGIVYRDLKPENVLVREDGHIMLSDFDLSLRC + l+klG G+ G+Vy t++ +A+K+++k + ++k+ ++++E +il++l+hp++ +ly fe+++ +lv+e+++gg+l++l + ++++e+ +k++++++l +leylH gi++rDlKpeN+L+ e+g+++++DF+l+ + ekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls..rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakel 127.6 3.5e-39 Protein kinase domain 688 Cluster-6998.2-1F PF00069.22 467 570 154 264 SMSFVGTHEYLAPEIIKGEGHGSAVDWWTFGIFLYELLFGKTPFKGSGNRATLFNVVGQ-----------PLRFPESPVVSFAARDLIRGLLVKEPQHRLAykrgATEIKQHPFF +sfvgt+eYlAPE++k+++++++vD+W+ G+ lyell+gk+pf+g+ ++ + + + q + +pe +s a+dl++ ll k+p++Rl a+e++qhp++ ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRlt....aeellqhpyl 73.0 1.6e-22 Protein kinase domain 688 Cluster-6998.2-1F PF07714.14 235 395 2 165 RLLKKLGCGDIGSVYLSELC----GTKCYFAMKVMDKASLASRkkLLRAQTEREILQSLDHPFLPTLYTHFETEKFSCLVMEFCPGGDLHT-LRQRQPGKHFTEQAVKFYVAEVLLALEYLHMLGIVYRDLKPENVLVREDGHIMLSDFDLSLRCAVSPTLIKSSS +l kklG G G+V+ +l +++ a+K++++ + +++ + +e +i+++l+hp + l+ e+ ++v+e+++gGdL++ Lr+++ +++t + + +++++ ++eyL+ +v rdl NvL++e+ ++ +sDf L+ + + + k+++ elgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateee..keefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkee 72.2 2.6e-22 Protein tyrosine kinase 688 Cluster-6998.2-1F PF07714.14 473 557 169 253 THEYLAPEIIKGEGHGSAVDWWTFGIFLYELLF-GKTPFKGSgNRATLFNVVGQPLRFPESPVVSFAARDLIRGLLVKEPQHRLAY +++apE++k + s+ D W fG+ l+E++ g++p++g + +++++ + + r ++ ++ + +l++ + ++p++R + pvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypgl.sneevleklkegkrlekpekcpeelyelmkqCweedpeeRptf 26.8 1.8e-08 Protein tyrosine kinase 688 Cluster-7054.0-1R CMGC_CDK-PITSLRE 1 151 5 155 NKINEGTYGIVYRARDKKSGEIVALKKVKMEKEREGFPLTSLREINILLSFQHPSTVNVKEVVVGSNLDSIFMVMEYMEHDLKGLMERMNQPFSQSEVKCLMLQLLEGVKYLHDNWVLHRDLKTSNLLLNNQGELKICDFGLARQYGSPLK nki+egtyg+vyrardkk+geivalkkvk+ekeregfpltslreinills++hps v+vkevvvgs+ldsif+v+ey+ehdlkgl+e+m++pfsqsevkclmlqllegvkylhdnwvlhrdlktsnlllnn+gelkicdfglarqygsplk nkidegtygvvyrardkktgeivalkkvklekeregfpltslreinillslhhpsivdvkevvvgskldsiflvleylehdlkgllesmkrpfsqsevkclmlqllegvkylhdnwvlhrdlktsnlllnnrgelkicdfglarqygsplk 305.0 3.5e-93 CMGC_CDK-PITSLRE 151 Cluster-7054.0-1R PF00069.22 2 148 6 150 KINEGTYGIVYRARDKKSGEIVALKKVKMEKEREGFPLTSLREINILLSFQHPSTVNVKEVVVGsnLDSIFMVMEYMEHD-LKGLMErMNQPFSQSEVKCLMLQLLEGVKYLHDNWVLHRDLKTSNLLLNNQGELKICDFGLARQYGS k+ eG++G Vy+a++k++g+ivA+Kk+k ek+++ + lrEi+il +++hp v+++ev+ d++++v+ey+e++ l+ l++ ++ +s++e+k ++ q+leg++ylH++ ++HrDlK++N+L++++gelKi+DFGla+++ s klGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee..kdelylvleyveggeladlls.rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakeles 143.7 4.3e-44 Protein kinase domain 151 Cluster-7054.0-1R PF07714.14 2 146 6 154 KINEGTYGIVYRARDK----KSGEIVALKKVKMEKEREGfPLTSLREINILLSFQHPSTVNVKEVVVgsNLDSIFMVMEYMEH-DLKGLMERM--NQPFSQSEVKCLMLQLLEGVKYLHDNWVLHRDLKTSNLLLNNQGELKICDFGLARQY k+ eG++G V++++ k k+ va+K++k e+++e l+e++i+ +++hp v++ v++ + +++++v+ey+e+ dL+ +++ +++++ +++ +++lq+ +G++yL+++ ++Hrdl + N Ll+++ ki+DfGLar+ klGeGafGeVvegtlkgekekkevkvavKtlkeeateee.keefleeakimkklkhpnivkllgvct..keepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardi 94.1 5.4e-29 Protein tyrosine kinase 151 Cluster-7079.0-2R RLK-Pelle_CR4L 53 316 2 270 KLVGRGSHGLVYKGVLDSGRMVAIKKPSKPAQKfliSDKSNEVENEIDILSKLQSPRLVNLVGFTRNDSqDRLLVVEFMSNGTLFDVLHLN----PRLPNWGRRIKLALQTAKALDVLHS-LNPPVIHRDVKSANVLIDRSFNARLGDFGLALRSTDNRLKSTP--PAGTMGYLDPCYVTPDNLSTKTDVFSFGILLLEIISGRKAIDLSYSPP--SVVDWAIPLIKIGKFLSIYDPKILPPKDGFVRKQLAVIAAKCVRSSRERRPSMKEVV +++G+gs+g vykg+l+ gr vaik+++k +++ +++++e+enE++iLskl++ +lv+L+G++++ + +rlLV+e+m+ng+L d Lh + ++ +W +Rik+al+ a+a++ Lhs +pp+iHrd+ks+N+L+d++++arl+DFglal + +++ +++ +agt+gyldp+yv++++l++k+Dv+sfG++lLe++sGrkai+ + ++ s+v+wa+pli+ g+ ++ d+++ ++++ + +++a +aa+cvrs++e+rp+m+evv rkiGkgsfgsvykgrlkdgrevaikraekares...keeeeefenEleiLsklrhkhlvrLlGyceeee.erlLVyeymengsLddhLhgkssssevalsWktRikialgvaraieyLhsyaeppiiHrdikssNiLldsewearlsDFglaltveeeeeskevsklagtlgyldpeyvsteeltpksDvysfGvvlLellsGrkaiseeeeeeeeslvewalplieegevrkvldkrlkaeeeleavekvarvaarcvrseveerpamsevv 302.7 1.6e-92 RLK-Pelle_CR4L 410 Cluster-7079.0-2R PF00069.22 50 317 2 260 SDQKLVGRGSHGLVYKGV-LDSGRMVAIKKPSKPAQKFLISdksNEVENEIDILSKLQSPRLVNLVGFTRNdSQDRLLVVEFMSNGTLFDVLHLNPRLPNWGRRiKLALQTAKALDVLHSLNppVIHRDVKSANVLIDRSFNARLGDFGLALRSTDNRLkSTPPAGTMGYLDPCYVTPDNLSTKTDVFSFGILLLEIISGRKAIDLSYSPPSVVDWAIPLIKIGKFLSiyDPKILPPKDGFVRKQLAVIAAKCVRSSRERRPSMKEVVE ++++ +G+Gs G Vyk+v ++g++vA+Kk +k +k ++v +Ei il kl++p++v+l+++ ++ +++++lv+e++++g+l+d+l+ + l+++ + k+a q++++l+ lHs + +iHrD+K++N+Lid++ + +++DFGla + + + t gt Yl P ++ + s+k+Dv+s G++l+e+++g+ + + +v + l ki k l + k p++ + +++ + k+++ +++R++++e+++ ekleklGeGsfGkVykaveketgkivAvKkikkekakkkke...kkvlrEikilkklkhpnivrlyevfee.kdelylvleyveggeladllsrkgslseeeak.kiakqilegleylHskg..iiHrDlKpeNiLidekgelKitDFGlakelesssk.ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg..etkeklpeaselseeakdllkkllkkdpkkRltaeellq 141.6 1.9e-43 Protein kinase domain 410 Cluster-7079.0-2R PF07714.14 52 318 4 259 QKLVGRGSHGLVYKGVLD-----SGRMVAIKKPSKPAQkfliSDKSNEVENEIDILSKLQSPRLVNLVGFTRnDSQDRLLVVEFMSNGTLFDVLHLN--PRLPNWGRRIKLALQTAKALDVLHSLNppVIHRDVKSANVLIDRSFNARLGDFGLALRS--TDNRLKSTPPAGTMGYLDPCYVTPDNLSTKTDVFSFGILLLEIIS-GRKAidlsysppsvvdwaIPLIKIGKFLSIYDPKILPPKDGFVRKQLAVIAAKCVRSSRERRPSMKEVVEW +k +G+G+ G V++g l+ + va+K+ ++ a+ +++++e+ +e++i++kl+ p++v+l+g+ +++ l+v+e++++G+L + L+ + + + + +++alq Ak+++ L+s + ++Hrd+ + NvL++++ ++++DfGLa + +d+ k++ + ++ p ++ ++++k+Dv+sfG+ll Ei++ g++ +p ++ ++l+ ++ + +k + ++l+ + +C++++ e+Rp++ke+ve gkklGeGafGeVvegtlkgekekkevkvavKtlkeeat....eeekeefleeakimkklkhpnivkllgvct.keepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskk..lvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep..............ypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelvek 122.5 1.2e-37 Protein tyrosine kinase 410 Cluster-7172.0-1F TKL-Pl-5 216 464 3 249 SKGLYQVAKWNGTKVSVKILDKESYSDPERINSFQHELTLLEKVRHPNVVQFIGAVTQKLPIMIVLEYHSKGDLSSYLQKKGRLKLSKALRFAREIARGMNYLHeCKPDAVIHGDLKPKNILLDYGGQLKVAGFGVLRLS--KVSDDKVKLERPDdidHASLYMAPEIFKDEMFDRSVDVYSFGLILYEMVEGVQPFSSKSPEEIVKLMSLNEKRPALKMKSKSAPQDLKELIEECSRLDSVRRPTFSEII ++g +++akW+gtkv+vk+l++e++sd e i++f++El+lLek+rHPnvvqF+gAvt++ p+miv ey+ kgdL+++l+kkg+l+ s+a++fa +iArG++yLH +kpd++iH+dLkpkn+lld g+lkva+Fg+ +l+ k+s+dk+kl+ + +++ ymaPe+f++e +d+svDv+sf+lilye++eg++pf++k+pee+ kl+ l++kRp ++ ksks+p++lkelieec + +RPtfseii efgevkkakWrgtkvavkvlkeellsdeeaikdfrdElelLeklrHPnvvqFlgAvtkqkplmivteylpkgdLakllkkkgklspsravkfaLdiArGlayLH.ekpdpiiHrdLkpknllldeagelkvadFglskllkvklsedkykltget...gsyrymaPevfrneeydksvDvfsfalilyelleglkpfaekepeeaaklvalegkRpefraksksypeglkelieecwskeaekRPtfseii 331.1 4e-101 TKL-Pl-5 589 Cluster-7172.0-1F PF07714.14 218 467 18 260 GLYQ-VAKWNGTKVSVKILdKESYSDPErINSFQHELTLLEKVRHPNVVQFIGAVTQKLPIMIVLEYHSKGDLSSYLQKK---GRLKLSKALRFAREIARGMNYLHECKpdaVIHGDLKPKNILLDYGGQLKVAGFGVLRLSKVSDDKvklERPDDIDHASLYMAPEIFKDEMFDRSVDVYSFGLILYEMVE-GVQPFSSKSPEEIVKLMsLNEKRpalKMKSKSAPQDLKELIEECSRLDSVRRPTFSEIIARL g ++ + + +kv vK+l ke++++ e ++f +e+++++k++hpn+v+++g++t++ p++iv+ey ++GdL+++L+kk +l+l++ l+fa++iA+Gm+yL++ k ++H dl +N+Ll+ + + k++ fG+ r + +d+ ++ ++ + +mapE++k++ f + Dv+sfG +l+E+++ g +p+++ s+ee+++ + ++kr k +++p++l+el+++C + d+ +Rptf+e++ +l gtlkgekekkevkvavKtl.keeateee.keefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLardiekddey...kkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevlekl.kegkr...lekpekcpeelyelmkqCweedpeeRptfkelvekl 178.4 1e-54 Protein tyrosine kinase 589 Cluster-7172.0-1F PF00069.22 222 464 19 259 VAKWNGTKVSVKILDKESYSDPERiNSFQHELTLLEKVRHPNVVQFIGAVTQKLPIMIVLEYHSKGDLSSYLQKKGRLKLSKALRFAREIARGMNYLHECKpdaVIHGDLKPKNILLDYGGQLKVAGFGVLRLSKVSDDkvklerPDDIDHASLYMAPEIFKDEMFDRSVDVYSFGLILYEMVEGVQPFSSKSPEE-----IVK---LMSLNEKRPALKMKSKSAPQDLKELIEECSRLDSVRRPTFSEII v k++g +v vK+++ke+ ++ ++ +++++E+++l+k++hpn+v++++++++k +++vley ++g+l ++l++kg l+ ++a ++a++i++g++ylH+ + +iH DlKp+NiL+d g+lK++ FG+ + + s + +++ + Y+APE+ k+++++++vDv+s G+ilye++ g +pfs+++ +e + + ++ + ++ + ++ ++++k+l++++ + d +R+t++e++ veketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk......ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeell 164.9 1.5e-50 Protein kinase domain 589 Cluster-7172.1-1F TKL-Pl-5 259 507 3 249 SKGLYQVAKWNGTKVSVKILDKESYSDPERINSFQHELTLLEKVRHPNVVQFIGAVTQKLPIMIVLEYHSKGDLSSYLQKKGRLKLSKALRFAREIARGMNYLHeCKPDAVIHGDLKPKNILLDYGGQLKVAGFGVLRLS--KVSDDKVKLERPDdidHASLYMAPEIFKDEMFDRSVDVYSFGLILYEMVEGVQPFSSKSPEEIVKLMSLNEKRPALKMKSKSAPQDLKELIEECSRLDSVRRPTFSEII ++g +++akW+gtkv+vk+l++e++sd e i++f++El+lLek+rHPnvvqF+gAvt++ p+miv ey+ kgdL+++l+kkg+l+ s+a++fa +iArG++yLH +kpd++iH+dLkpkn+lld g+lkva+Fg+ +l+ k+s+dk+kl+ + +++ ymaPe+f++e +d+svDv+sf+lilye++eg++pf++k+pee+ kl+ l++kRp ++ ksks+p++lkelieec + +RPtfseii efgevkkakWrgtkvavkvlkeellsdeeaikdfrdElelLeklrHPnvvqFlgAvtkqkplmivteylpkgdLakllkkkgklspsravkfaLdiArGlayLH.ekpdpiiHrdLkpknllldeagelkvadFglskllkvklsedkykltget...gsyrymaPevfrneeydksvDvfsfalilyelleglkpfaekepeeaaklvalegkRpefraksksypeglkelieecwskeaekRPtfseii 330.9 4.6e-101 TKL-Pl-5 632 Cluster-7172.1-1F PF07714.14 261 510 18 260 GLYQ-VAKWNGTKVSVKILdKESYSDPErINSFQHELTLLEKVRHPNVVQFIGAVTQKLPIMIVLEYHSKGDLSSYLQKK---GRLKLSKALRFAREIARGMNYLHECKpdaVIHGDLKPKNILLDYGGQLKVAGFGVLRLSKVSDDKvklERPDDIDHASLYMAPEIFKDEMFDRSVDVYSFGLILYEMVE-GVQPFSSKSPEEIVKLMsLNEKRpalKMKSKSAPQDLKELIEECSRLDSVRRPTFSEIIARL g ++ + + +kv vK+l ke++++ e ++f +e+++++k++hpn+v+++g++t++ p++iv+ey ++GdL+++L+kk +l+l++ l+fa++iA+Gm+yL++ k ++H dl +N+Ll+ + + k++ fG+ r + +d+ ++ ++ + +mapE++k++ f + Dv+sfG +l+E+++ g +p+++ s+ee+++ + ++kr k +++p++l+el+++C + d+ +Rptf+e++ +l gtlkgekekkevkvavKtl.keeateee.keefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLardiekddey...kkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevlekl.kegkr...lekpekcpeelyelmkqCweedpeeRptfkelvekl 178.2 1.2e-54 Protein tyrosine kinase 632 Cluster-7172.1-1F PF00069.22 265 507 19 259 VAKWNGTKVSVKILDKESYSDPERiNSFQHELTLLEKVRHPNVVQFIGAVTQKLPIMIVLEYHSKGDLSSYLQKKGRLKLSKALRFAREIARGMNYLHECKpdaVIHGDLKPKNILLDYGGQLKVAGFGVLRLSKVSDDkvklerPDDIDHASLYMAPEIFKDEMFDRSVDVYSFGLILYEMVEGVQPFSSKSPEE-----IVK---LMSLNEKRPALKMKSKSAPQDLKELIEECSRLDSVRRPTFSEII v k++g +v vK+++ke+ ++ ++ +++++E+++l+k++hpn+v++++++++k +++vley ++g+l ++l++kg l+ ++a ++a++i++g++ylH+ + +iH DlKp+NiL+d g+lK++ FG+ + + s + +++ + Y+APE+ k+++++++vDv+s G+ilye++ g +pfs+++ +e + + ++ + ++ + ++ ++++k+l++++ + d +R+t++e++ veketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk......ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeell 164.7 1.7e-50 Protein kinase domain 632 Cluster-7172.2-1F TKL-Pl-5 259 378 3 121 SKGLYQVAKWNGTKVSVKILDKESYSDPERINSFQHELTLLEKVRHPNVVQFVGAVTQEVPMMIVLEYHARGDLSGYLQKKGRLSPSKALRFGIEIARGMNCLHeCKPEPIIHCGLEPKC ++g +++akW+gtkv+vk+l++e++sd e i++f++El+lLek+rHPnvvqF+gAvt++ p+miv ey+++gdL+ +l+kkg+lsps+a++f ++iArG+++LH +kp+piiH+ L+pk+ efgevkkakWrgtkvavkvlkeellsdeeaikdfrdElelLeklrHPnvvqFlgAvtkqkplmivteylpkgdLakllkkkgklspsravkfaLdiArGlayLH.ekpdpiiHrdLkpkn 181.7 1.6e-55 TKL-Pl-5 430 Cluster-7172.2-1F PF07714.14 260 365 17 124 KGLYQ-VAKWNGTKVSVKILdKESYSDPErINSFQHELTLLEKVRHPNVVQFVGAVTQEVPMMIVLEYHARGDLSGYLQKK---GRLSPSKALRFGIEIARGMNCLHECK +g ++ + + +kv vK+l ke++++ e ++f +e+++++k++hpn+v+++g++t+e p++iv+ey + GdL+ +L+kk +l+ ++ l+f ++iA+Gm+ L++ k egtlkgekekkevkvavKtl.keeateee.keefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskk 71.9 3.3e-22 Protein tyrosine kinase 430 Cluster-7172.2-1F PF00069.22 265 374 19 124 VAKWNGTKVSVKILDKESYSDPERiNSFQHELTLLEKVRHPNVVQFVGAVTQEVPMMIVLEYHARGDLSGYLQKKGRLSPSKALRFGIEIARGMNCLHECKpepIIHCGL v k++g +v vK+++ke+ ++ ++ +++++E+++l+k++hpn+v+++++++++ +++vley g+l +l++kg ls+++a ++ +i++g++ lH+ + iiH+ l veketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskg...iiHrDl 58.3 5e-18 Protein kinase domain 430 Cluster-7172.3-1F TKL-Pl-5 2 81 169 249 DEIFDKSVDVYSFGIMLYEMIEGALPFSSKDPEEATKLLCLEAGRPAIKSKSK-YPSDLKELIEQCWHPDSAMRPAFSDII +e +dksvDv+sf+++lye++eg+ pf++k+peea+kl +le Rp +++ksk yp++lkelie+cw+ + + RP+fs+ii neeydksvDvfsfalilyelleglkpfaekepeeaaklvalegkRpefraksksypeglkelieecwskeaekRPtfseii 90.1 1.4e-27 TKL-Pl-5 181 Cluster-7172.3-1F PF07714.14 3 83 181 259 EIFDKSVDVYSFGIMLYEMIE-GALPFSSKDPEEATKLLclEAGRPaIKSKSKYPSDLKELIEQCWHPDSAMRPAFSDIIVR + f ++ Dv+sfG++l+E+++ g+ p+++ ++ee+++ l ++g+ ++ ++k p++l+el++qCw+ d++ Rp f++++ + kkftsksDvWsfGvllwEiftlgeepypglsneevlekl..kegkr.lekpekcpeelyelmkqCweedpeeRptfkelvek 51.3 6.2e-16 Protein tyrosine kinase 181 Cluster-7172.3-1F PF00069.22 5 80 174 258 FDKSVDVYSFGIMLYEMIEGALPFSSKDPEE-----ATK----LLCLEAGRPAIKSKSKYPSDLKELIEQCWHPDSAMRPAFSDI ++k+vDv+s G++lye++ g pfs+++ +e +++ l l+ + +++ +s+ ++++k+l++++++ d R+ ++++ yskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeel 40.0 1.9e-12 Protein kinase domain 181 Cluster-7195.0-2R CAMK_CAMKL-CHK1 21 275 1 256 YELGKLLGYGAFAKVYHARDLRTGQSVAIKAMSKQRIFKGNLTAHIKREIAILRRLRHPHIVRLLEVMATKTKIYFVLEYAKGGELFAKIAK-GRFSEDLSRKYFQQLISAVDYCHSRGVFHRDLKPENLLLDENWELKVTDFGLSAVSDQIRPDGLLHTLCGTPAYVAPEILAKKGYDGAKVDIWSCGIILYVLNAGYLPFNDPNLMVMYRKIYRGEFRCPKWTSPEMKQFLTRILDPNPDTRITMPEIVNDPWF yelG+llG g+fakv++ardl+tg+svaik ++k++++k +l+++ikrei++l+++rhp++vrllev+atk+kiy+vley+kGGelf+kiak gr++ed +rkyfqqlisavdychsrgv+hrdlkpenlllde+ +lkv+dfGlsa+++q+r dgllht cGtPayvaPe+l+kkgydgak+d+WscG+il+vl agylPf+d nl+ +yrki+++ef++pkw+s+e+k++++r+ldpnp+trit+ ei++++Wf yelGrllGegtfakvklardletgesvaikvldkekvlkaklveqikreisvlklvrhpnvvrllevlatkskiylvleyvkGGelfekiakkgrlkedearkyfqqlisavdychsrgvyhrdlkpenllldekgnlkvsdfGlsalaeqlredgllhttcGtPayvaPevlkkkgydgakadvWscGvilfvllagylPfedenlvelyrkilkaefklpkwlskeakklisrlldpnpetritieeileeeWf 434.5 9.3e-133 CAMK_CAMKL-CHK1 433 Cluster-7195.0-2R PF00069.22 21 275 1 264 YELGKLLGYGAFAKVYHARDLRTGQSVAIKAMSKQRIFKGNLtAHIKREIAILRRLRHPHIVRLLEVMATKTKIYFVLEYAKGGELFAKIA-KGRFSEDLSRKYFQQLISAVDYCHSRGVFHRDLKPENLLLDENWELKVTDFGLSAVSDQIRPdglLHTLCGTPAYVAPEILAKKGYdGAKVDIWSCGIILYVLNAGYLPFNDPNLMV----MYRK------IY---RGEFRCPKWTSPEMKQFLTRILDPNPDTRITMPEIVNDPWF ye + lG G+f+kVy a++ +tg+ vA+K ++k+++ k + ++ rEi+il++l+hp+ivrl+ev+ +k+++y+vley++ggel+ + kg +se+ +k+++q++++++y+Hs+g++HrDlKpeN+L+de+ elK+tDFGl++ ++ + l++ +gt+ Y+APE+l +++y ++kvD+Ws+G+ily l +g pf++ + ++++ i + +++ ++ s+e+k++l+++l+ +p +R+t+ e++++p++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeney.skkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 247.4 1e-75 Protein kinase domain 433 Cluster-7195.0-2R PF07714.14 22 271 2 258 ELGKLLGYGAFAKVYHARDL----RTGQSVAIKAMSKQRifKGNLTAHIKREIAILRRLRHPHIVRLLEVMATKTKIYFVLEYAKGGELFAKIAKG----RFSEDLSRKYFQQLISAVDYCHSRGVFHRDLKPENLLLDENWELKVTDFGLSAVSDQIRPDGLLHTLCGTPAYVAPEILAKKGYDgAKVDIWSCGIILYV-LNAGYLPFNDPNLMVMYRKIYRGE-FRCPKWTSPEMKQFLTRILDPNPDTRITMPEIVN elgk lG Gaf++V++++ ++ ++va+K ++++ + + ++++ +e++i+++l+hp+iv+ll v+ + ++++v+ey++gG+L + k +++ + ++ +q+ ++++y +s+ + Hrdl N Ll+en k++DfGL+ + ++ ++apE+l +k + k D+Ws G++l+ ++ g p+++ + + +++k+ +g+ ++p+ +++e+++++++ ++ +p+ R t+ e+v+ elgkklGeGafGeVvegtlkgekekkevkvavKtlkeea..teeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkft.sksDvWsfGvllwEiftlgeepypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelve 126.9 5.3e-39 Protein tyrosine kinase 433 Cluster-720.0-2F WNK_NRBP 1 79 178 256 NELVDIYSFGMCMLELVTCEYPYSECKNQAQIYKKVTSGIKPAALNKVQHLEVKQFIEKCLVPVSQRLSAMELLKDPFL nelvdiysfGmc+lelvt+eyPyseckn+aqiykkvtsg+kpaal+kv++ ev++fiekcl+++s+rlsa ellkdpfl nelvdiysfGmcllelvtleyPysecknaaqiykkvtsgkkpaalekvkdaevrkfiekclaeaserlsakellkdpfl 126.9 7.9e-39 WNK_NRBP 156 Cluster-720.0-2F PF00069.22 3 79 177 264 LVDIYSFGMCMLELVTCEYPYSECKNQAQIYKKVTS----------GIKPAALNKVQHLEVKQFIEKCLVP-VSQRLSAMELLKDPFL vD++s G+ ++el+t + p+s+ k++ +++k+++ + + ++ e+k++++k+l ++Rl+a+ell++p+l kvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 28.3 6.9e-09 Protein kinase domain 156 Cluster-720.0-2F PF07714.14 4 62 187 244 VDIYSFGMCMLELVT-CEYPYSECkNQAQIYKKVTSGIKPAALNKVqHLEVKQFIEKCLV D++sfG+++ E++t +e py+++ +++++++k+++g + ++ +k+ + e+++++++C+ sDvWsfGvllwEiftlgeepypgl.sneevleklkegkrlekpekc.peelyelmkqCwe 27.2 1.5e-08 Protein tyrosine kinase 156 Cluster-7203.0-2R RLK-Pelle_RLCK-VIII 220 494 1 275 ALIGEGSYGRVYFAQLSNGKDVAVKKLDVSSEPDSNTEFLTQVSMVSRLKNENLVELFGYCVDGNLRVLAYEFATMGSLHDILHGRKGVQGAQPGPVLDWTQRVRIAVDAARGLEYLHEKVQPSIIHRDIRSSNVLLFEDYKAKIADFNLSNQAPDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQQSLVTWATPRLSEDKVKQCVDPKLKGEYPPKGVAKLAAVAALCVQYEAEFRPNMSIVVKAL +liGeGsygrvy+a+l++gk++avkkld s+e++sn+efl+qvs+vsrlk+enlvel+gycv+g+lrvlayefat+gslhdilhGrkgv+gaqpgpvl+w+qrv+iav+aarGleylhekvqP++ihrdirssnvllf+d+kakiadfnlsnqapdmaarlhstrvlgtfgyhapeyamtGqltqksdvysfGvvllelltGrkpvdht+prgqqslvtwatprlsedkvkqcvdpklk+eyppk+vaklaavaalcvqyea+frpnmsivvkal sliGeGsygrvyyavlkdgkaaavkkldkskeeesneeflaqvsvvsrlkhenlvellgycvegelrvlayefatkgslhdilhGrkgvkgaqpgpvlsweqrvkiaveaarGleylhekvqPavihrdirssnvllfdddkakiadfnlsnqapdmaarlhstrvlgtfgyhapeyamtGqltqksdvysfGvvllelltGrkpvdhtlprgqqslvtwatprlsedkvkqcvdpklkdeyppkavaklaavaalcvqyeadfrpnmsivvkal 556.8 5.2e-170 RLK-Pelle_RLCK-VIII 612 Cluster-7203.0-2R PF07714.14 221 494 6 260 LIGEGSYGRVYFAQLS-----NGKDVAVKKLDVSSEPDSNTEFLTQVSMVSRLKNENLVELFGYCVDGNLRVLAYEFATMGSLHDILHGRkgvqgaQPGPVLDWTQRVRIAVDAARGLEYLHEKVqpsIIHRDIRSSNVLLFEDYKAKIADFNLSNQAPDMAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKPvdhtmprgqqslvtwaTPRLSEDKVKQCVDPKLKGEYPPKGVAKLAAVAALCVQYEAEFRPNMSIVVKAL +GeG++G+V+ ++l+ + +vavK+l+ +++ ++++efl+++++ ++lk++n+v+l g c++++ ++ e+++ G+L++ L+ + + + l+ ++ +++a++ A+G+eyL++k ++Hrd+++ NvLl e+ ++ki+Df L+++ ++ ++++ + + apE +++++t+ksDv+sfGv+l E++t g++p p+ls+ +v + ++ + + e p k ++l+ + C+++++e Rp+++ +v+ l klGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk......eekekltlkdllsfalqiAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep................ypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 156.8 3.9e-48 Protein tyrosine kinase 612 Cluster-7203.0-2R PF00069.22 220 432 5 204 ALIGEGSYGRVYFAQ-LSNGKDVAVKKLDVSSEPDSN-TEFLTQVSMVSRLKNENLVELFGYCVDGNLRVLAYEFATMGSLHDILHgrkgvqG------AqpgpvldwtQRVRIAVDAARGLEYLHEKVqpsIIHRDIRSSNVLLFEDYKAKIADFNLSNQAPDMAArlhSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRG +GeGs+G+Vy a ++gk vAvKk++++++ +++ +++l+ ++++ +lk +n+v+l++++ + + ++l e++ g+l+d+l+ + + +ia ++gleylH+k iiHrD+ ++N+L+ e+ + Ki+DF l++++ t + gt Y APE + + ++k+Dv+s Gv+l+elltg+ p ++ + eklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls......rkgslsee.........eakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgke 133.7 4.8e-41 Protein kinase domain 612 Cluster-7228.0-2F CK1_CK1 1 202 35 236 KTKHPQLHYESKIYMILQGGTGVPNLKWFGVEGEYNIMVIDLLGPSLEDLFNYCNRKFSLKTVLMLADQLINRVEYVHSRGFLHRDIKPDNFLMGLGRKANQVYIIDFGLAKKYRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLRAGTKKQKYDKISEKKMLTPIEVLCKSY ktkhpql+yesk+y+ilqggtg+pnlkwfgveg+yn++v+dllgpsledlfnyc+rkfslktvlmladqlinrveyvhs+gflhrdikpdnflmglgrkanqvyiidfglakkyrd +t+khipyrenknltgtaryasvnthlg+eqsrrddleslgyvl+yflrgslpwqgl+agtkkqky+kisekk+ t+ievlcksy ktkhpqllyesklyrilqggtgipnlkwfgvegdynvlvldllgpsledlfnycsrkfslktvlmladqlinrveyvhskgflhrdikpdnflmglgrkanqvyiidfglakkyrdaktkkhipyrenknltgtaryasvnthlgieqsrrddleslgyvllyflrgslpwqglkagtkkqkyekisekkvstsievlcksy 426.3 2.1e-130 CK1_CK1 402 Cluster-7228.0-2F PF00069.22 36 185 73 212 NIMVIDLLG-PSLEDLFNyCNRKFSLKTVLMLADQLINRVEYVHSRGFLHRDIKPDNFLMGlgrKANQVYIIDFGLAKKYRDLQThkhipyreNKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLRA-GTKKQKYDK ++v++++ +l+dl + + ++s +++ +a q+++ +ey+Hs+g++HrD+Kp+N+L+ + +++ i+DFGlak+++ ++ ++ +gt +Y + + e s+ D+ slG +l+ +l g p++g + ++++++d+ lylvleyveggeladlls.rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLid...ekgelKitDFGlakelesssk........ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldq 66.4 1.6e-20 Protein kinase domain 402 Cluster-7228.0-2F PF07714.14 37 227 77 256 IMVIDLLG-PSLEDLFNYC--NRKFSLKTVLMLADQLINRVEYVHSRGFLHRDIKPDNFLMGlgrKANQVYIIDFGLAKKYRDLQTHkhipyRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLR-GSLPWQGLragTKKQKYDKISEKKMLTPIevlcKSYPLEFTSYFHYCRSLRFEDKPDYSYL ++v++++ +L++ + ++k++lk++l +a q+ + +ey +s+ ++Hrd+ N L+ + ++v i DfGLa++ ++ ++ +++++ + ++ ++ + + + + D s G +l+ + g+ p++gl ++++ ++k++e+k l+ ++ p e+++ + C + + e+ p+++ l livteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLls...enkvvkisDfGLardiekddey.....kkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypgl...sneevleklkegkrlekp....ekcpeelyelmkqCweedpeeRptfkel 34.9 6.5e-11 Protein tyrosine kinase 402 Cluster-7256.0-1F RLK-Pelle_LRR-V 1 149 113 270 LHEVCSPSVIHKNFKSANILLDSELNPHLSDCGLASLVHEPDQ---------ASGYSAPEVTMSGQYTIKSDVYSFGVVMLELLSGRKPFDSSRPRAEQSLVRWATPQLHDIDALSKMVDPALKGLYPVKSLSRFADVIALCVQPEPEFRPPMSEVVQ lhevcsp+v+hknfksanilld+elnp++sdcGla+l+++ + ++gysaPev++sg+yt+ksDvysfGvvmlell grkpfDssrpr+eqsLvrwatpqlhdidal+kmvDpalkglyp+kslsrfad+ialcvq+epefrPpmsevvq lhevcsppvvhknfksanilldeelnprvsdcGlaallkssserqlsekllaslgysaPeveesgaytvksDvysfGvvmlelltgrkpfDssrprseqsLvrwatpqlhdidalekmvDpalkglypakslsrfadiialcvqkepefrPpmsevvq 273.3 1.5e-83 RLK-Pelle_LRR-V 234 Cluster-7256.0-1F PF00069.22 7 149 117 260 PSVIHKNFKSANILLDSELNPHLSDCGLASLVHEPD------QASGYSAPEVTMSGQYTIKSDVYSFGVVMLELLSGRKPFDSSRPRAEQSLVRWAtpqLHDIDALSKMVDPALKG---LypvksLSRFADVIALCVQPEPEFRPPMSEVVQ ++iH+ K++NiL+d++ + ++D Gla+ +++ + Y APEv + +y+ k+Dv+s Gv+++ell+g+ pf +++ + +++ l+ i + + ++ +l+ l + + d++ +++ +p+ R+ ++e++q kgiiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldq...lekilkilgetkeklpeasel.....seeakdllkkllkkdpkkRltaeellq 66.8 1.2e-20 Protein kinase domain 234 Cluster-7256.0-1F PF07714.14 8 151 124 260 SVIHKNFKSANILLDSELNPHLSDCGLASLVH---------EPDQASGYSAPEVTMSGQYTIKSDVYSFGVVMLELLS-GRKPfdssrpraeqslvrwaTPQLHDIDALSKMvDPALKGLYPVKSLSRFADVIALCVQPEPEFRPPMSEVVQAL +++H++ + N+Ll+++ +sD GLa+ ++ e + + apE+ +++++t+ksDv+sfGv++ E+++ g++p p+l++ ++l+k+ + + p k +++++++ C++ +pe Rp ++e+v+ l klvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep................ypglsneevlekl.kegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 63.3 1.3e-19 Protein tyrosine kinase 234 Cluster-7326.0-2R RLK-Pelle_LRR-IX 158 428 1 271 ENILGQGGFGTVYKGELHDGTKIAVKRMEGGVIMGKGLAEFKSEIAVLTKVRHRHLVALLGYCLDGNEKLLVYEYMPQGTLSRHLFNWAAEGLQPLEWTKRLTIALDVARGVEYLHGLAHQSFIHRDLKPSNILLGDDMRAKVGDFGLVRLAPEGKGSIETRIAGTFGYLAPEYAVTGRVTTKVDVFSFGVILMELITGRKALDESQPEESMHLVTWFRRMHLNKEIFNKAIDSTIDLNEETLASISTVAELAGHCCAREPYQRPDMGHAV +nilg+ggfg+vykgelhdgtkiavkrme +vi +kgl+efkseiavltkvrhr+lvallgycl+gne+llvyeympqgtls+hlf++ +egl+plew+krl+ialdvargveylh+lahqsfihrdlkpsnillgdd+rakv dfglv+lap+gk s+etr+agtfgylapeyavtgrvttkvdvfsfgv+lmelitgrkaldes++ee++hlvtwfrr++++ke ++kaid+t++l+eetl+sis+vaelaghc+arep+qrpdmghav dnilgrggfgvvykgelhdgtkiavkrmeaavisnkgleefkseiavltkvrhrnlvallgyclegnerllvyeympqgtlskhlfeykeeglkplewkkrlsialdvargveylhslahqsfihrdlkpsnillgddlrakvsdfglvklapdgklsvetrlagtfgylapeyavtgrvttkvdvfsfgvvlmelitgrkaldeskaeeevhlvtwfrrvlidkeklkkaidptleldeetlksiskvaelaghctarepkqrpdmghav 532.2 1.7e-162 RLK-Pelle_LRR-IX 568 Cluster-7326.0-2R PF00069.22 156 429 2 260 SEENILGQGGFGTVYKGE-LHDGTKIAVKRMEGGVIMGKGLAEFKSEIAVLTKVRHRHLVALLGYCLDGNEKLLVYEYMPQGTLSRHLFnwaaEGLQpLEWTKRLTIALDVARGVEYLHglaHQSFIHRDLKPSNILLGDDMRAKVGDFGLVRLAPEGKGsiETRIAGTFGYLAPEYAVTGRVTTKVDVFSFGVILMELITGRKALDESQPEESMHLVTwfRRMHLNKEIFNkaidsT----------IdlneetlasISTVAELAGHCCAREPYQRPDMGHAVN ++++ lG+G+fG+Vyk+ ++g ++AvK+++ + k ++ +Ei++l k++h+++v l++++ + +e +lv ey+++g+l ++l + + l+ ++ ia +++g+eylH ++++iHrDlKp+NiL+ ++ K++DFGl++ + +++ t + gt YlAPE + ++++kvDv+s Gvil+el+tg+ + +++ +e+++ + ++++ +i++ + + +++ +l +++++p +R+ + ++++ ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls....rkgs.lseeeakkiakqilegleylH...skgiiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekel..dqlekilkilg.....etkeklpeasel.........seeakdllkkllkkdpkkRltaeellq 159.9 5.1e-49 Protein kinase domain 568 Cluster-7326.0-2R PF07714.14 158 428 4 257 ENILGQGGFGTVYKGELH-----DGTKIAVKRMEGGViMGKGLAEFKSEIAVLTKVRHRHLVALLGYCLDGNEKLLVYEYMPQGTLSRHLFNWaaEGLQPLEWTKRLTIALDVARGVEYLHglaHQSFIHRDLKPSNILLGDDMRAKVGDFGLVRLA-PEGKGSIETRIAGTFGYLAPEYAVTGRVTTKVDVFSFGVILMELIT-GRKAldesqpeesmhlvtwFRRMhLNKEIFNKAiDSTIDLNEETLaSISTVAELAGHCCAREPYQRPDMGHAV ++ lG+G fG+V++g+l+ + +k+avK ++ + + + +ef +e+++++k++h+++v+llg c+++++ l+v ey+++G+L+++L + e ++l+ ++ l +al++A+G+eyL+ +++++Hrdl N+Ll +++ +k++DfGL r + + + +++ + ++apE ++++t+k Dv+sfGv+l+E++t g++ ++++ n+e+++k ++ l++ + ++++el +C++++p +Rp++ + v gkklGeGafGeVvegtlkgekekkevkvavKtlkeea.teeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk..eekekltlkdllsfalqiAkGmeyLe...skklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep...............ypgl.sneevlekl.kegkrlekpek.cpeelyelmkqCweedpeeRptfkelv 154.6 1.9e-47 Protein tyrosine kinase 568 Cluster-7338.0-1F CAMK_CDPK 61 309 1 259 YELGETIGRGKFGSVVHCRCKASGQEFACKTLRKG-------EEIVHREVEIMQHLSGHPGVVLLKAVYEDAESFHLVMELCSGGRLLDQMAREGQYGERQAANIIKELMLAIRYCHEMGVVHRDVKPENILLATSG---QMKLADFGLAVRILDGQTLTGIVGSPAYVAPEVLSGNYSEKVDIWSAGVLLHALLVGTLPFQGDSLEAVFEAIKKEKLDFSGDVWDSVSQPARDLLSRMLTRSVSTRLTANDVLKHPWI yelg+++GrG+fG v+ + ka+g+e+A+K+++k e v+rev+i++hlsgh+ vv lk++yed++s hlvmelc+gg lld++ ++g+y er+aa+++++++ ++++cH++gvvhrD+KPeN+ll+++ ++k++DFGl+v + +g++l++ivGsp yvaPEvl+ +y++++d+WsaGv+l+ ll g+ pf++++ e++f+a+ k++ldf+ + w+svs+ a+dl++r+L++ +++Rlta++vL+hpW+ yelgkelGrGefGvvrlatekatgeevAvKsiskrklskaedvedvrrevkilkhlsghknvvqlkgayedkdsvhlvmelceggelldrilargkyseraaakvvrqilevvaacHskgvvhrDlKPeNflltskeedaplkaiDFGlsvfvkegerledivGspyyvaPEvlkrsygkeadvWsaGvilyillcgvppfwaeteeeifkavlkaeldfksepwksvseeakdlvrrlLekdpkkRltaeqvLehpWl 316.1 1.5e-96 CAMK_CDPK 396 Cluster-7338.0-1F PF00069.22 61 309 1 264 YELGETIGRGKFGSVVHCRCKASGQEFACKTLRKGEEI------VHREVEIMQHLSgHPGVVLLKAVYEDAESFHLVMELCSGGRLLDQMAREGQYGERQAANIIKELMLAIRYCHEMGVVHRDVKPENILLATSGQMKLADFGLAVRILDGQTLTGIVGSPAYVAPEVL-SGNYSEKVDIWSAGVLLHALLVGTLPFQGDSLEAVFEAIKKE---------KLDFSGDVWDSVSQPARDLLSRMLTRSVSTRLTANDVLKHPWI ye e++G+G+fG+V+ ++ k++g+++A+K+++k ++ v rE++i+++l+ hp +v l+ v+e+ ++++lv+e+++gg l d + r+g++ e++a +i+k+++ +++y+H++g++HrD+KpeNiL+ ++g++K++DFGla ++ +++lt +vg++ Y+APEvl + +ys+kvD+Ws+Gv+l ll g+ pf+g++ + +e++ ++ + +++ ++++++s+ a+dll+++l++ ++Rlta+++l+hp++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklk.hpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 238.7 4.5e-73 Protein kinase domain 396 Cluster-7338.0-1F PF07714.14 62 267 2 223 ELGETIGRGKFGSVVHCRCK----ASGQEFACKTLRKGE-----EIVHREVEIMQHLsGHPGVVLLKAVYEDAESFHLVMELCSGGRLLDQMARE---GQYGERQAANIIKELMLAIRYCHEMGVVHRDVKPENILLATSGQMKLADFGLAVRILD---GQTLTGIVGSPAYVAPEVLS-GNYSEKVDIWSAGVLLHALLV-GTLPFQGDSLEAVFEAIKKEK elg+++G+G+fG+Vv++++k + ++ a Ktl+++ e + +e++im++l hp +v l +v+ ++e+ +v+e+++gG Ll+ + ++ + ++ ++++++ +++y +++ +vHrd+ N+Ll+++ ++k++DfGLa +i + ++ ++ + ++apE+l+ +++++k D+Ws Gvll+ ++ g p++g s e v+e++k++k elgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkkl.khpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevleklkegk 118.6 1.9e-36 Protein tyrosine kinase 396 Cluster-7347.0-0R CAMK_CAMKL-LKB 319 578 2 264 ERKIGAGSYGKVVLYRSRLDGKEYAIKSFHKSHLLKLRVAPSETAMSDVLREVVIMKMLSHPNIVKLVEVIDDPTTDHFYMVLEYVEGgKWVCEGSGFPC--ALNESTARKYLRDIVAGLMYLHAHNIVHGDIKPDNLLITGDGMVKIGDFSVSQVFEDGNDVLRRSPGTPVFTAPECCLGLTYHGKAADTWAVGVTLYCMVFGKYPFLGDTLQDTYDKIANNLLVLPD--NMNPLLKNLIEGLLCKDPLQRMTLEDVSQHAWV ++k+G+GsyGkvvl+rs+ d+k yaik +hks+l klrv+++eta++dvlre++i+k+l+hpn+vkL+eviddp++d++++vleyveG ++v+egs+ + al e++arky+Rd+vagl+YLhah++vhgD+kP+nll++++G vki+Df+vs+vfe+++d l+r++gtPvftaPe++ g +y+g+aaD+wa+Gv+Ly++v+Gk+Pf+gdtl+++y+ki n+ l lp+ +++p lk+l+e+lL+kdp +r++le+v++h+Wv vkklGkGsyGkvvlvrstkdeklyaikvvhksrlrklrvlaeetaledvlreiailkkldhpnvvkLleviddpesdklllvleyveG.glvlegssatgrkalgealarkyfRdvvagleYLhahkvvhgDlkPenllvsssGkvkisDfgvsrvfeedddalvrtagtPvftaPealsgsayegraaDvwalGvcLyvlvlGklPfvgdtlveiyekivnkplalpeevkvspelkDllerlLkkdpaerlsleevaehpWv 395.2 1.1e-120 CAMK_CAMKL-LKB 657 Cluster-7347.0-0R PF00069.22 316 578 1 264 YVRERKIGAGSYGKVVLYRSRLDGKEYAIKSFHKSHLLKLRVapsetamSDVLREVVIMKMLSHPNIVKLVEVIDDptTDHFYMVLEYVEGGKWVCEGSgFPCALNESTARKYLRDIVAGLMYLHAHNIVHGDIKPDNLLITGDGMVKIGDFSVSQVFEDGNDvLRRSPGTPVFTAPECClGLTYHGKAADTWAVGVTLYCMVFGKYPFLGDTLQDTYDKIANN----LL---------VLPDNMNPLLKNLIEGLLCKDPLQRMTLEDVSQHAWV y +++k+G Gs+GkV+ +++ +gk++A+K + k++ k + ++vlrE+ i+k l+hpniv+l+ev+ + +d++y+vleyvegg+ s ++l+e++a+k+++ i++gl ylH+++i+H D+Kp+N+Li+ +g++Ki+DF +++ +e +++ l+ gt+ + APE + + ++k++D W++Gv+ly++++gk pf g++ ++++ k++++ l ++++++ +k+l++ ll+kdp +R+t e++ qh ++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.......kkvlrEikilkklkhpnivrlyevfee..kdelylvleyveggeladlls.rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk.ltsfvgtreYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 199.1 5.7e-61 Protein kinase domain 657 Cluster-7347.0-0R PF07714.14 319 574 4 258 ERKIGAGSYGKVVLYRSRLDGKEYAIKSFHKSHllklRVAPSETAMSDVLREVVIMKMLSHPNIVKLVEVIDdpTTDHFYMVLEYVEGGKWVCEGSGF--PCALNESTARKYLRDIVAGLMYLHAHNIVHGDIKPDNLLITGDGMVKIGDFSVSQVF-EDGNDVLRRSPGTPV-FTAPECCLGLTYHgKAADTWAVGVTLYCMVF-GKYPFLGDTLQDTYDKIANN-LLVLPDNMNPLLKNLIEGLLCKDPLQRMTLEDVSQ ++k+G+G++G+Vv + + + ++ +k K+ + +e++++++l+e+ imk l+hpnivkl+ v+ +++ ++v+eyvegG+ +l+ ++ ++ ++i +G+ yL+++++vH d+ N L++ + +vki+Df +++ +d + + +++ +pv ++apE+ ++ +++D W+ Gv+l+ ++ g+ p+ g + +++++k+ ++ l p+++++ l++l++ + +dp +R t++++ + gkklGeGafGeVvegtlkgekekkevkvavKtl....keeateeekeefleeakimkklkhpnivkllgvct..keepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkft.sksDvWsfGvllwEiftlgeepypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelve 106.4 9.6e-33 Protein tyrosine kinase 657 Cluster-737.0-0R STE_STE20-Fray 1 99 164 262 GTPCWMAPEVLQPGTGYDFKADIWSFGITALELAHGHAPFSKYPPMKVLLMTIQNAPPGLDYDRDKRFSKSFKEMVAMCLVKDQTKRPTAEKLLRHSFF gtpcwmaPevl+ +gydfkadiwsfGitalelahGhaP+skyPp+kvllmt+qna+p+ldy+rdk+fsksfke+va+clvkd++krPtaekll+hsff gtpcwmaPevleqlkgydfkadiwsfGitalelahGhaPlskyPplkvllmtlqnavplldyerdkkfsksfkelvalclvkdpskrPtaekllkhsff 197.0 3e-60 STE_STE20-Fray 119 Cluster-737.0-0R PF00069.22 1 99 159 264 GTPCWMAPEVLqPGTGYDFKADIWSFGITALELAHGHAPFSKYPPMK---VLLMT------IQNaPPGLDYDRDKRFSKSFKEMVAMCLVKDQTKRPTAEKLLRHSFF gt+ ++APEvl +++y+ k+D+Ws G++ +el g+ pfs+ + l++ i + + +++++++ +s+++k+++ +l kd++kR+tae+ll+h+++ gtreYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.etkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 68.7 3.2e-21 Protein kinase domain 119 Cluster-737.0-0R PF07714.14 4 95 171 258 CWMAPEVLQPGTgYDFKADIWSFGITALELAH-GHAPFSKYPPMKVLLMTIQnappGLDYDRDKRFSKSFKEMVAMCLVKDQTKRPTAEKLLR WmapE+l+ ++ + k+D+WsfG++ E++ g+ p++++ +++vl + + g ++ + +++++e++ C+ +d+++Rpt ++l++ kWmapEslkekk.ftsksDvWsfGvllwEiftlgeepypglsneevleklke....gkrlekpekcpeelyelmkqCweedpeeRptfkelve 50.1 1.4e-15 Protein tyrosine kinase 119 Cluster-7394.0-1R RLK-Pelle_L-LEC 13 208 2 200 TRIIGYGAFGTVYKGILPATGDIVAVKRCSH-NGQGKAEFLSELSIIGTLRHRNLVRLQGWCHEKGEILLVYDLMPNGSLDKALF--ESRMVLPWAHRRKILLGVASALAYLHQECENQVIHRDVKTSNIMLDEGFNARLGDFGLARQTEHDKSPDATVAAGTMGYLAPEYLLTGRATEKTDVFSYGAVVLEVASGRRP ++++G g+fG+vYkg+l+ +g vAvKr+s+ + qg+ eF++e++ii++lrhrnlV+L+Gwc+ek+e+llvy++mpngsldk Lf e++ vl+w++R ki+ g+asaL+yLH+e+e++v+hrd+k+sn++LDe fnarLgDFGlar ++h+k+p++t +agt+gYlape+ tg+at+++DV+s+G+v+Lev++grrp eellGeggfGkvYkgvlkskgrevAvKriskeskqgekeFvaevkiisrlrhrnlVkLlGwcrekkelllvyeympngsldklLfkeeeeavlsweqRykivkgiasaLlyLHeeleqvvlhrdikasnvlLDeefnarLgDFGlarlldhgkepqttrvagtlgYlapelvktgkattesDVysFGvvlLevvcgrrp 302.2 2.7e-92 RLK-Pelle_L-LEC 208 Cluster-7394.0-1R PF00069.22 12 208 3 196 STRIIGYGAFGTVYKGILPATGDIVAVKRCSHNGQGKAE---FLSELSIIGTLRHRNLVRLQGWCHEKGEILLVYDLMPNGSLDKALFeSRMVLPWAHRRKILLGVASALAYLHQECenqVIHRDVKTSNIMLDEGFNARLGDFGLARQTEHDKSpdATVAAGTMGYLAPEYLLTGRATEKTDVFSYGAVVLEVASGRRP + +G G+fG+Vyk++ +tg+ivAvK+ +++ + k + +l+E++i+ +l+h+n+vrl ++++ek e++lv +++++g+l+++l +++l+ ++ +ki+ ++++l+ylH+++ +iHrD+K++Ni++de + +++DFGla++ e++++ +t gt YlAPE l + + ++k+Dv+s+G +++e+ +g+ p kleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls.rkgslseeeakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkpp 167.2 3e-51 Protein kinase domain 208 Cluster-7394.0-1R PF07714.14 13 207 4 205 TRIIGYGAFGTVYKGILP----ATGDIVAVKRCSH--NGQGKAEFLSELSIIGTLRHRNLVRLQGWCHEKGEILLVYDLMPNGSLDKALFES--RMVLPWAHRRKILLGVASALAYLHQeceNQVIHRDVKTSNIMLDEGFNARLGDFGLARQT-EHDKSPDATVAAGTMGYLAPEYLLTGRATEKTDVFSYGAVVLEVAS-GRR ++ +G GafG+V++g+l + vavK +++ + + k+efl+e++i+ +l+h+n+v+l g+c +++++l+v +++++G+L+k L ++ + l + ++ l +A++++yL++ ++++Hrd+ + N++l+e+ ++++DfGLar++ ++d+ + + a + ++apE l +++ t+k+Dv+s+G ++ E+++ g++ gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLes...kklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgee 144.6 2.2e-44 Protein tyrosine kinase 208 Cluster-7486.0-2R CMGC_GSK 227 509 1 283 AERVVGSGSFGVVYQAKCLETGESVAIKKVLQDRRYKNRELQIMRLFEHPNVVQLKHCFYSTTEKNEVYLNLVLEYVSETVYRASRHYTRVNQYMPVLYVQLYTYQICRALNYMHNVIGVCHRDIKPQNLLVNPHTHQLKICDFGSAKMLVPGEPNISYICSRYYRAPELIFGATEYTTAIDMWSVGCVMAELLIGQPLFPGESSVDQLVEIIKVLGTPTREEIKCMNPNYSEFKFPHIKAHPWHKIFPKRMPPEAVDLVSRLLQYSPTLRCTALEACAHPFF aervvg+gsfgvv+qakcletge+vaikkvlqd+ryknrelqimrl++hpnvv+lkh+f+sttek+e+ylnlvleyv+etvyr ++hy+++nq +p++yv+lytyqicral+y+h+v+gvchrdikpqnllvnp+thqlk+cdfgsak+lv+gepnisyicsryyrapelifgateyttaid+ws+gcv+aell+gqplfpges+vdqlveiikvlgtptreeikcmnpny+efkfp+ikahpwhk+f kr+ppeavdlvsrllqysp+lrctalea++hpff aervvgtgsfgvvfqakcletgetvaikkvlqdkryknrelqimrlldhpnvvalkhlffsttekdelylnlvleyvpetvyrvakhysklnqrlpliyvklytyqicralayihkvvgvchrdikpqnllvnpkthqlklcdfgsakvlvkgepnisyicsryyrapelifgateyttaidiwsagcvlaelllgqplfpgesgvdqlveiikvlgtptreeikcmnpnytefkfpqikahpwhkvfkkrlppeavdlvsrllqyspnlrctalealvhpff 602.0 1.1e-183 CMGC_GSK 630 Cluster-7486.0-2R PF00069.22 225 509 1 264 YMAERVVGSGSFGVVYQAKCLETGESVAIKKVLQDRRYKN------RELQIMRLFEHPNVVQLKHCFYStteknEVYLNLVLEYVSETVyrASRHYTrVNQYMPVLYVQLYTYQICRALNYMHnVIGVCHRDIKPQNLLVNpHTHQLKICDFGSAKMLVPGEPNISYICSRYYRAPELIfGATEYTTAIDMWSVGCVMAELLIGQPLFP---GES----SVDQLVEIIKVLGtptreEIKCMNP----NysefkfphikahpwhkifpkrmPPEAVDLVSRLLQYSPTLRCTALEACAHPFF y ++ +G+GsfG+Vy+a+ etg+ vA+Kk+ ++++ k+ rE++i++ ++hpn+v+l+++f++ + +l lvleyv+++ ++++ ++ ++ ++ +++qi+++l+y+H g++HrD+Kp+N+L++ ++ +lKi+DFG ak l +++ s++++r+Y+APE++ +++ey++++D+Ws+G++++ell g+p+f+ g++ +dql++i+k+lg e k p ++ea dl+++ll++ p+ R+ta e+++hp++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee.....kdelylvleyvegge..ladlls.rkgslseeeakkiakqilegleylH.skgiiHrDlKpeNiLid.ekgelKitDFGlakelessskltsfvgtreYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.....etkeklpeasel......................seeakdllkkllkkdpkkRltaeellqhpyl 219.4 3.5e-67 Protein kinase domain 630 Cluster-7486.0-2R PF07714.14 228 429 4 210 ERVVGSGSFGVVYQAKCL----ETGESVAIKKVLQDRRYK-----NRELQIMRLFEHPNVVQLKHCFYsttEK-NevyLNLVLEYVSETVYRASRHYTRVNQYMPVLYVQLYTYQICRALNYMHNViGVCHRDIKPQNLLVNpHTHQLKICDFGSAKMLVPG---EPNISYICSRYYRAPELIFGATeYTTAIDMWSVGCVMAELLI-GQPLFPGE ++ +G+G+fG V+++++ ++ +va+K++ ++ + + +e++im+ ++hpn+v+l + + ++ + l +v+eyv++ + + ++ ++ + + + +++qi+++++y+++ + Hrd+ +N L++ ++++ ki+DfG a+ + + + + ++ + apE ++ + +t++ D+Ws G ++ E++ g+ +pg gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvct...keep...llivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLesk.klvHrdlaarNvLls.enkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekk.ftsksDvWsfGvllwEiftlgeepypgl 90.0 1e-27 Protein tyrosine kinase 630 Cluster-7492.0-1R CMGC_CDK-CRK7-CDK9 80 226 1 147 FEKLDKIGQGTYSNVYRARDLDQGKIVALKKVRFDNLEPESVRFMAREIHILRRLDHPNIIKLEGLVTSRMSCSLYLVFEYMEHDLAGLASHPSVKFTEPQVKCYMQQLLRGLDHCHSRNVLHRDIKGSNLLIDNNGILKIADFGLA fekl+kiG+Gtys+vy+a+dl++gkivalkkvr+dnle+esvrfmarei+ilr+ldhpn+ikleglvts++s+slylvfeym+hdl+glas+p++kf+epqvkcy++qll+Gl+hchsr+vlhrdikgsnllidn+g+lkiadfGla feklekiGeGtysevykakdletgkivalkkvrldnleeesvrfmareikilrkldhpnvikleglvtsklsgslylvfeymdhdltglasapdlkfsepqvkcylkqllsGlehchsrgvlhrdikgsnllidnegvlkiadfGla 275.1 4.2e-84 CMGC_CDK-CRK7-CDK9 226 Cluster-7492.0-1R PF00069.22 80 226 1 145 FEKLDKIGQGTYSNVYRARDLDQGKIVALKKVRFDNLEPESVRFMAREIHILRRLDHPNIIKLEGLVTSrmSCSLYLVFEYMEHD-LAGLAShPSVKFTEPQVKCYMQQLLRGLDHCHSRNVLHRDIKGSNLLIDNNGILKIADFGLA +ekl k+G+G++++Vy+a++ ++gkivA+Kk++ ++ + ++ + ++rEi+il++l+hpni++l + +++ + +lylv+ey+e++ la l s +++++e ++k +++q+l+gl+++Hs++++HrD+K +N+Lid++g lKi+DFGla yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee..kdelylvleyveggeladlls.rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGla 149.6 7e-46 Protein kinase domain 226 Cluster-7492.0-1R PF07714.14 82 226 3 151 KLDKIGQGTYSNVYRARDL----DQGKIVALKKVRFDNLEPESVRFMArEIHILRRLDHPNIIKLEGLVTSRMScsLYLVFEYMEH-DLAG-LASH-PSVKFTEPQVKCYMQQLLRGLDHCHSRNVLHRDIKGSNLLIDNNGILKIADFGLA +k+G+G++++V++++ ++ va+K+++ ++ e e+ +f+ e++i+++l+hpni+kl g++t++ + l++v+ey+e+ dL L ++ + k+t ++ ++++q+ +G+++ +s++++Hrd+ N L+++n + ki+DfGLa lgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefle.eakimkklkhpnivkllgvctkeep..llivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLa 90.4 7.3e-28 Protein tyrosine kinase 226 Cluster-7492.2-1R CMGC_CDK-CRK7-CDK9 3 143 141 281 SADFGLASFFDPHQSRPLTSRVVTLWYRPPELLLGATYYGTAVDLWSAGCILAELYSGKPIMPGRTEVEQLHKIFKLCGSPSEEYWKKSKLPHATIFKPQQPYKRRVAEMFHDFPAPALALAETLLSIDPADRGSAASALK adfGla++fd+++++pltsrvvtlWyrpPelllGat yg+avdlWs+Gcilael++gkpi+pGrteveqlhkifklcGsPseeyWkk+klp+at+fkpq+pykrr++e+f+++++ al+l e+lls+dP++rg+a++alk iadfGlatsfdadkkqpltsrvvtlWyrpPelllGatkygvavdlWsvGcilaellagkpilpGrteveqlhkifklcGsPseeyWkkvklplatsfkpqkpykrrlketfkelsesalellekllsldPekrgtakdalk 238.4 6.2e-73 CMGC_CDK-CRK7-CDK9 143 Cluster-7492.2-1R PF00069.22 4 143 140 260 ADFGLASFFDPHQSrpLTSRVVTLWYRPPELLlGATYYGTAVDLWSAGCILAELYSGKPIMP---GRT----EVEQLHKIFKLCGSPSEEYWKKSKLphatifkpqqpykrrvaemfhdfPAPALALAETLLSIDPADRGSAASALK +DFGla+ ++ +++ lts+v+t +Y++PE+l +++ y+++vD+Ws+G+il+el++gkp+++ g++ e++ql+ki+k+ g +e++ ++s+l + a+ l + ll+ dp +R +a+++l+ tDFGlakelesssk..ltsfvgtreYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeasel.......................seeakdllkkllkkdpkkRltaeellq 81.2 5.2e-25 Protein kinase domain 143 Cluster-751.0-2R RLK-Pelle_LRR-XI-2 76 190 1 111 EVIGEGGCGRVYKATLPgtNGKEIAVKKIIQPSRDAeeLSEEDSKLLTKKMRQIRSEIQTVGQIRHRNLLPLLAHLPQPDCHYLVYEYMKNGSVQDILQEVAEGRREMDWLARFK e++g+Gg+G+vyk++l+ ++k +avkk+ + + da ls+e+sk + kk+rqir+e++t+g+irhrnll+lla++ ++d+h+lvyeym++Gs++d+l++v+ g e+ W ar + ellgrGgnGkvykveld..ddkvvavkkvkkaedda..lsdeeskeskkkarqirkeletlgkirhrnllsllayvrksdehllvyeymekGsledvlkkvrsgevelsWearlr 133.8 5.5e-41 RLK-Pelle_LRR-XI-2 190 Cluster-751.0-2R PF00069.22 75 175 4 91 LEVIGEGGCGRVYKATLPgTNGKEIAVKKIIQPSRDAEELseedsklltkkmRQIRSEIQTVGQIRHRNLLPLLAHLPQPDCHYLVYEYMKNGSVQDILQE le +GeG+ G+Vyka+ ++gk++AvKki + +++ ++ +++++Ei+ + +++h+n++ l+ + ++d ylv ey+++g+++d+l++ leklGeGsfGkVykavek.etgkivAvKkikkekakkkke............kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsr 44.6 7.2e-14 Protein kinase domain 190 Cluster-751.0-2R PF07714.14 76 187 5 107 EVIGEGGCGRVYKATLP---GTNGKEIAVKKIiQPsrdaeelseE----DsklltkkMRQIRSEIQTVGQIRHRNLLPLLAHLPQPDCHYLVYEYMKNGSVQDILQEV-AEGRREMDWLA + +GeG G+V+++tl ++ ++avK++ + e + ++++ +e+++ +++h+n++ ll+ + + +++v ey+++G++++ L++ ++ + ++++l kklGeGafGeVvegtlkgekekkevkvavKtl.ke.........eateee.......keefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdll 35.7 3.6e-11 Protein tyrosine kinase 190 Cluster-7567.0-1F RLK-Pelle_DLSV 51 315 2 266 NKIGEGGFGPVYKGVLSDGTIIAVKQLSSRSKQGNREFINEIGMISALQHPNLVKLFGCCTESNQLLLIYEYLENNSLARALFGsDDQQLNLDWSTRKKICLGIAKGLAYLHEESRLKIVHRDIKAANVLLDKGLNAKISDFGLAKLDDEENTHINT-RIAGTLGYMAPEYAMRGYLTDKADVYSFGIVALEIISGKSNTNYRPKEEFVYLLDWAYVLQEQGNLLDLVDPILGSKYSKEEAARVLNIALSCTNPSPSLRPPMSSVI nk+GeGgfg vYkg+l+dg+ +Avk+ls++skqg++ef ne+ +i++lqh nlvkL gcc+e+++ ll+yeylen+sL ++lf ++++ +ldW+tr ki+ gia+Gl+YLheesrlki+hrD+Ka+N+LLdk +n+ki+DFGla+l +e++t+++t r++gtlgYmaPeya++g l+ k+DvysfG++ lei+sGk+n++ + +ee+ +ll++a+ l+e+++ll+lvd+ l ++++kee+ r+++ial c++ +p+ rp ms+v+ nklGeGgfgkvYkgkledgkevAvkrlskkskqgkeefknevvliaklqhrnlvkLlgcciegeekllvyeylenksLdkflfd.eekkkeldWktrfkiikgiarGllYLheesrlkiihrDlKasNiLLdkemnpkiaDFGlarlfeedqteastkrvvgtlgYmaPeyalegqlseksDvysfGvlvleivsGkknsslkeeeeaeelleeawklweeekllelvdkslkeeaekeevlrcieiallcvqekpekrptmsevv 364.6 2.1e-111 RLK-Pelle_DLSV 414 Cluster-7567.0-1F PF07714.14 50 316 4 258 ANKIGEGGFGPVYKGVLS-----DGTIIAVKQLSSRSKQG-NREFINEIGMISALQHPNLVKLFGCCTESNQLLLIYEYLENNSLARALFGSdDQQLNLDWSTRKKICLGIAKGLAYLHEESrlkIVHRDIKAANVLLDKGLNAKISDFGLAKLD-DEENTHINTRIAGTLGYMAPEYAMRGYLTDKADVYSFGIVALEIIS-GKSNtnyrpkeefvylldwaYVLQEQGNLLDLVDPILGSKYSKEEAARVLNIALSCTNPSPSLRPPMSSVIR +k+GeG fG V++g l+ + + +avK+l++++++ ++ef++e+ ++++l+hpn+vkl g+ct++++ll++ ey+e+++L + L + +++ +l+ ++ +++l iAkG++yL++++ +vHrd+ a NvLl+++ +kisDfGLa+ ++++++ +++ + +mapE +++ +t k+Dv+sfG++ Ei++ g++ y ++ ++l+ ++ + ++ +++ ++ +C + +p+ Rp ++++++ gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk.eekekltlkdllsfalqiAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep................ypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelve 168.4 1.2e-51 Protein tyrosine kinase 414 Cluster-7567.0-1F PF00069.22 49 251 3 199 RANKIGEGGFGPVYKGV-LSDGTIIAVKQLSSRSKQGNRE--FINEIGMISALQHPNLVKLFGCCTESNQLLLIYEYLENNSLARALFgsddQQLNLDWSTRKKICLGIAKGLAYLHEESrlkIVHRDIKAANVLLDKGLNAKISDFGLAKLDDEENThiNTRIAGTLGYMAPEYAMRGYLTDKADVYSFGIVALEIISGKSNTNY + +k+GeG+fG Vyk+v ++g i+AvK+++ ++++ ++e +++Ei ++ l+hpn+v+l+++++e+++l+l+ ey+e+++la++l ++ +l+ ++ kki+ i++gl+ylH+++ i+HrD+K +N+L+d+ + Ki+DFGlak +++++ t + gt Y+APE + + k+Dv+s G++ +e+++gk + kleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls....rkgslseeeakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsg 165.9 7.2e-51 Protein kinase domain 414 Cluster-7567.1-2F RLK-Pelle_DLSV 36 139 163 266 SRGYMAPEYAMRGYLTDKADVYSFGIVALEIISGKSNTNYRPKEEFVYLLDWAYVLQEQGNLLDLVDPILGSKYSKEEAARVLNIALSCTNPSPSLRPPMSSVI + gYmaPeya++g l+ k+DvysfG++ lei+sGk+n++ + +ee+ +ll++a+ l+e+++ll+lvd+ l ++++kee+ r+++ial c++ +p+ rp ms+v+ tlgYmaPeyalegqlseksDvysfGvlvleivsGkknsslkeeeeaeelleeawklweeekllelvdkslkeeaekeevlrcieiallcvqekpekrptmsevv 105.9 1.7e-32 RLK-Pelle_DLSV 238 Cluster-7567.1-2F PF07714.14 39 140 172 258 YMAPEYAMRGYLTDKADVYSFGIVALEIIS-GKSNtnyrpkeefvylldwaYVLQEQGNLLDLVDPILGSKYSKEEAARVLNIALSCTNPSPSLRPPMSSVIR +mapE +++ +t k+Dv+sfG++ Ei++ g++ y ++ ++l+ ++ + ++ +++ ++ +C + +p+ Rp ++++++ WmapEslkekkftsksDvWsfGvllwEiftlgeep................ypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelve 32.2 4.2e-10 Protein tyrosine kinase 238 Cluster-7640.0-0F TKL-Pl-4 38 309 2 253 KGVIARGTFGTVHRGIYDGQDVAVKLLDWGeegHRTEAEIASLRAAFTQEVAVWHKLDHPNVTKFIGATMgssdlnvqtenghigmPSNICCVVVEYLPGGALKSYLIKNRRKKLAFKVVVQIALDLARGLSYLHSQKIVHRDVKTENMLLDKNRTVKIADFGVARVEASnPNDMTGETGTLGYMAPEVLNGNPYNRKCDVYSFGICLWETYCCDMPYPDLSFSEVTSAVVRQNLRPEIPRCCPSSLANVMKRCWDANPDKRPEMDEVVAML + +ia+G++g++++g y++qdvavK+l++g +++e+e+a+l+++f+qevav++kl+H+nv+kfiga++ ++ +c+v+eyl+gg+lk+yl+k+++kkl++kvvv++ald+argl+ylhs+kivHrD+k+en+lld++++vKiaDfGvarvea+ +++mt+etGt+++maPEvl+++py+rk+Dvysfgi+lWe++++++py dl++ ++++avv++nlRpeip+++p++la++++rcw+a+p+kRpe++e+v++l gekiaeGalgklykgkykeqdvavKileag...eekeeeaaelekefkqevavlsklkHknvvkfigact................kepalcivteylkggslkkylekkkkkklklkvvvklaldiargleylhskkivHrDlkaenllldeekvvKiaDfGvarveaq.seemtaetGtyrwmaPEvlekkpydrkvDvysfgivlWelltgkvpyedltplqaavavvqknlRpeipkevpealaellercwkadpekRpefseivkll 383.4 4.2e-117 TKL-Pl-4 420 Cluster-7640.0-0F PF07714.14 38 309 4 260 KGVIARGTFGTVHRGIYD------GQDVAVKLLdwgEEGHRTEAeiaslRAAFTQEVAVWHKLDHPNVTKFIGATMgssdlnvQ--TenghigmpsniCCVVVEYLPGGALKSYLIKN-RRKKLAFKVVVQIALDLARGLSYLHSQKIVHRDVKTENMLLDKNRTVKIADFGVARVE--ASNPNDMTGETGTLGYMAPEVLNGNPYNRKCDVYSFGICLWETYC-CDMPYPDLSFSEVTSAVvRQNLRPEIPRCCPSSLANVMKRCWDANPDKRPEMDEVVAML + +++G+fG+V++g+++ ++vavK l +e+++ e+ +++f++e+++ +kl+hpn+ k++g+ + + + ++v+ey++gG L+++L k+ +++kl +k ++++al++A+G++yL+s+k+vHrd+ + N+Ll++n++vki+DfG+ar ++ ++ ++++ + +mapE+l+ + ++ k Dv+sfG++lwE ++ +++pyp+ls +ev++++ +++ r e p+ cp++l+++mk+Cw+++p++Rp+++e+v l gkklGeGafGeVvegtlkgekekkevkvavKtl...keeateee.....keefleeakimkklkhpnivkllgvct.......keep...........llivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevlekl.kegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 211.4 9e-65 Protein tyrosine kinase 420 Cluster-7640.0-0F PF00069.22 39 307 5 260 GVIARGTFGTVHRGI--YDGQDVAVKLLDWGEEGHRTEaeiaslrAAFTQEVAVWHKLDHPNVTKFIGATMGssdlnvqtenghigmpSNICCVVVEYLPGGALKSYLIknRRKKLAFKVVVQIALDLARGLSYLHSQKIVHRDVKTENMLLDKNRTVKIADFGVARVEASNPNdMTGETGTLGYMAPEVLNGNPYNRKCDVYSFGICLWETYCCDMPYPDLSFSEVTSAVVRQ-----------NLRPEIPRCCPSSLANVMKRCWDANPDKRPEMDEVVA + +G+fG+V +++ +g+ vAvK ++ ++ +++e ++++E+++ +kl+hpn+ +++++ ++ ++v+ey++gg l+++l r+++l+ + + +ia +++gl+ylHs++i+HrD+K+eN+L+d+++ +Ki+DFG+a+ s+ + +t ++gt Y+APEvl++n+y +k+Dv+s G+ l+e ++ +p+++ + +e +++ ++q ++ + ++ +++++ +++k++++ +p kR+ ++e+++ eklGeGsfGkVykaveketgkivAvKkikkekakkkke.......kkvlrEikilkklkhpnivrlyevfee................kdelylvleyveggeladlls..rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk.ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellq 172.6 6.4e-53 Protein kinase domain 420 Cluster-7705.0-0R STE_STE20-Pl 1 171 8 178 GKGSYGAVYKARNIRTSELVAIKVISLSEGEEGYEEIRGEIEMLQQCSHPNVVRYLGSYQGEEYLWIVMEYCGGGSVADLMNVTDEPLEEYQIAYICREALKGLSYLHSIFKVHRDIKGGNILLTDQGEVKLGDFGVAAQLTRTMSKRNTFIGTPHWMAPEVIQESRYDGK gkgsygavykar+++tselva+kvisl+egeegyeeirgeie+lqqc+hpnvvrylgsyqge+ylwivmeycgggsvadl+++t+e+lee+qiayicrealkgl+ylhsifkvhrdikggnillt+qgevklgdfgvaaqltrtmskrntfigtphwmapeviqesrydgk gkgsygavykardlktselvavkvisltegeegyeeirgeiellqqcnhpnvvrylgsyqgedylwivmeycgggsvadllsiteealeeeqiayicrealkglaylhsifkvhrdikggnillteqgevklgdfgvaaqltrtmskrntfigtphwmapeviqesrydgk 364.2 2e-111 STE_STE20-Pl 171 Cluster-7705.0-0R PF00069.22 1 169 8 175 GKGSYGAVYKARNIRTSELVAIKVISLSEGEEGYE-EIRGEIEMLQQCSHPNVVRYLGSYQGEEYLWIVMEYCGGGSVADLMNvTDEPLEEYQIAYICREALKGLSYLHSIFKVHRDIKGGNILLTDQGEVKLGDFGVAAQLTRTMSkRNTFIGTPHWMAPEVIQESRYD G+Gs+G Vyka++ +t++ vA+K+i+ ++ ++ e +++ Ei++l++++hpn+vr++++++ +++l++v+ey+ gg++adl++ ++ l+e ++ i+++ l+gl+ylHs +HrD+K NiL++++ge+K++DFG+a++l+++ + ++f+gt++++APEv++e++y+ GeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls.rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk.ltsfvgtreYlAPEvlkeneys 174.2 2.2e-53 Protein kinase domain 171 Cluster-7705.0-0R PF07714.14 1 169 8 184 GKGSYGAVYKARNI----RTSELVAIKVISLSEGEEGYEEIRGEIEMLQQCSHPNVVRYLGSYQGEEYLWIVMEYCGGGSVADLMNVT--DEPLEEYQIAYICREALKGLSYLHSIFKVHRDIKGGNILLTDQGEVKLGDFGVAAQL--TRTMSKRNTFIGTPHWMAPEVIQESRYD G+G++G V++++ +++ va+K+++ + ee ee+ e++++++++hpn+v++lg + ee l+iv+ey+ gG++ + ++ + +e+l+ ++ ++++ kG++yL+s vHrd+ N+Ll+++ vk++DfG+a ++ + +++k+++ +WmapE+++e+++ GeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkft 125.8 1.1e-38 Protein tyrosine kinase 171 Cluster-7752.0-1F CMGC_CLK 308 521 114 327 YAVMHDLHLIHTDLKPENILLVSSEYIKVPDYKgSTRSLRDACYRRIPKSSAIKVIDFGSTTYDKQGQTYTVSTRHYRAPEVILGLGWSYPCDIWSVGCILIELCSGEALFQTHENLEHLAMMERVLGPLPQDMLKRADRHAEKYVRRG-RLDWPEGATSRDSIKAVLKLPRLQNLVMQHVDHSAGDFIHLLQGLLRYDPSERFSAREALKHPFF a mh+l+lihtdlkpenillvssey+kvpdyk s++s ++++++r+pkssaik+idfgs+t+d+q +++ vstrhyrapevilglgwsypcd+wsvgcil+elcsgealfqthenlehlammervlgplp++m+kradr+aeky+rrg rl+wpega+sr+s+kav klprl+nl++++vdhsag++i+llqgll+ydpser++a+ealkhpff vaymhelrlihtdlkpenillvsseyvkvpdyk.srsskegkafkrlpkssaiklidfgsatfdeqehssvvstrhyrapevilglgwsypcdlwsvgcilvelcsgealfqthenlehlammervlgplpehmikradrraekyfrrgarlnwpegaasreslkavkklprlknlilkkvdhsagelidllqgllkydpserltakealkhpff 396.8 4.9e-121 CMGC_CLK 638 Cluster-7752.0-1F PF00069.22 310 521 113 264 VMHDLHLIHTDLKPENILLVSseyikvpdykgstrslrdacyrripkSSAIKVIDFGSTTYDKQGQ--TYTVSTRHYRAPEVILGLGWSYPCDIWSVGCILIELCSGEALFQTHE-------NLEHLAMMERVLGplpqdMLKRADRH---AekyvrrgrldwpegatsrdsikavlklprlqnlvmqhvdhsAGDFIHLLQGLLRYDPSERFSAREALKHPFF +H+ ++iH DlKpeNiL+ + ++ +K++DFG + ++++ t v tr+Y+APEv+ + + s ++D+Ws+G+il+el +g+ +f+ ++ +l++l ++ ++lg k + ++ ++++ll+ ll++dp++R++a+e+l+hp++ ylHskgiiHrDlKpeNiLide..........................kgelKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.....etkeklpeasel.........................................seeakdllkkllkkdpkkRltaeellqhpyl 104.1 5.1e-32 Protein kinase domain 638 Cluster-7752.0-1F PF07714.14 311 431 120 220 MHDLHLIHTDLKPENILLVSseyikvpdykgstrslrdacyrripkSSAIKVIDFGSTTYDKQGQTYT-----VSTRHYRAPEVILGLGWSYPCDIWSVGCILIELCS-GEALFQTHENLEHLAMME +++ +l+H dl N+Ll + ++ +k+ DfG + ++ ++y+ ++ apE++ + D+Ws G +l+E+++ ge +++ +n e l++++ LeskklvHrdlaarNvLlse..........................nkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevleklk 28.8 4.4e-09 Protein tyrosine kinase 638 Cluster-7752.0-2F CMGC_CLK 138 252 1 115 YKIHSKMGEGTFGQVLECWDKERKEMVAIKVIRGVRKYRDAAMIEIEMLQQLGRHDIGGNRCVQIRNWFDYRNHICIVFEKLGPSLYDFLRKNNYRSFHIDLVREIGRQLLECVA yki skmgegtfg+vlecwd+erke+vaikv+r+++kyrdaamiei++l++l+++d g+rcvq+++wfdyrnhicivfeklgpslydflrkn+yrsf idlvr++grqlle+va ykilskmgegtfgrvlecwdrerkelvaikvvrsikkyrdaamieidvlkklakndklgsrcvqlkewfdyrnhicivfeklgpslydflrknkyrsfpidlvrdlgrqllesva 220.9 1.6e-67 CMGC_CLK 638 Cluster-7752.0-2F PF00069.22 138 252 1 112 YKIHSKMGEGTFGQVLECWDKERKEMVAIKVIRGVRKYR---DAAMIEIEMLQQLGrhdigGNRCVQIRNWFDYRNHICIVFEKLG-PSLYDFLRknNYRSFHIDLVREIGRQLLECVA y+ ++k+GeG+fG+V+++ +ke++++vA+K+i+ ++ ++++ Ei++l++l ++ v++ ++f +++++v+e + +l d+l+ + s+ + +++i +q+le ++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklk.....hpnivrlyevfeekdelylvleyveggeladlls..rkgslseeeakkiakqilegle 43.2 2e-13 Protein kinase domain 638 Cluster-7752.0-2F PF07714.14 139 237 2 103 KIHSKMGEGTFGQVLECWDK----ERKEMVAIKVIR-GVRKY-RDAAMIEIEMLQQLgRHDiggnRCVQIRNWFDYRNHICIVFEKL-GPSLYDFLRKN-NYRSFHI ++++k+GeG+fG+V e+ k +++ va+K+++ + ++ +++ + e++++++l +h+ + v++ + +++++iv+e + g +L +fLrk+ + +++++ elgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkkl.khp....nivkllgvctkeepllivteyvegGdLlkfLrkkeekekltl 25.4 4.9e-08 Protein tyrosine kinase 638 Cluster-7752.1-2F CMGC_CLK 138 216 1 79 YKIHSKMGEGTFGQVLECWDKERKEMVAIKVIRGVRKYRDAAMIEIEMLQQLGRHDIGGNRCVQIRNWFDYRNHICIVS yki skmgegtfg+vlecwd+erke+vaikv+r+++kyrdaamiei++l++l+++d g+rcvq+++wfdyrnhiciv ykilskmgegtfgrvlecwdrerkelvaikvvrsikkyrdaamieidvlkklakndklgsrcvqlkewfdyrnhicivf 146.1 9.1e-45 CMGC_CLK 249 Cluster-7752.1-2F PF00069.22 138 217 1 78 YKIHSKMGEGTFGQVLECWDKERKEMVAIKVIRGVRKYR---DAAMIEIEMLQQLGrhdigGNRCVQIRNWFDYRNHICIVST y+ ++k+GeG+fG+V+++ +ke++++vA+K+i+ ++ ++++ Ei++l++l ++ v++ ++f +++++v yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklk.....hpnivrlyevfeekdelylvle 35.1 5.8e-11 Protein kinase domain 249 Cluster-7752.2-2F CMGC_CLK 138 464 1 327 YKIHSKMGEGTFGQVLECWDKERKEMVAIKVIRGVRKYRDAAMIEIEMLQQLGRHDIGGNRCVQIRNWFDYRNHICIVFEKLGPSLYDFLRKNNYRSFHIDLVREIGRQLLECVAFMHDLHLIHTDLKPENILLVSSEYIKVPDYKgSTRSLRDACYRRIPKSSAIKVIDFGSTTYDKQGQTYTVSTRHYRAPEVILGLGWSYPCDIWSVGCILIELCSGEALFQTHENLEHLAMMERVLGPLPQDMLKRADRHAEKYVRRG-RLDWPEGATSRDSIKAVLKLPRLQNLVMQHVDHSAGDFIHLLQGLLRYDPSERFSAREALKHPFF yki skmgegtfg+vlecwd+erke+vaikv+r+++kyrdaamiei++l++l+++d g+rcvq+++wfdyrnhicivfeklgpslydflrkn+yrsf idlvr++grqlle+va+mh+l+lihtdlkpenillvssey+kvpdyk s++s ++++++r+pkssaik+idfgs+t+d+q +++ vstrhyrapevilglgwsypcd+wsvgcil+elcsgealfqthenlehlammervlgplp++m+kradr+aeky+rrg rl+wpega+sr+s+kav klprl+nl++++vdhsag++i+llqgll+ydpser++a+ealkhpff ykilskmgegtfgrvlecwdrerkelvaikvvrsikkyrdaamieidvlkklakndklgsrcvqlkewfdyrnhicivfeklgpslydflrknkyrsfpidlvrdlgrqllesvaymhelrlihtdlkpenillvsseyvkvpdyk.srsskegkafkrlpkssaiklidfgsatfdeqehssvvstrhyrapevilglgwsypcdlwsvgcilvelcsgealfqthenlehlammervlgplpehmikradrraekyfrrgarlnwpegaasreslkavkklprlknlilkkvdhsagelidllqgllkydpserltakealkhpff 642.3 9.4e-196 CMGC_CLK 581 Cluster-7752.2-2F PF00069.22 138 464 1 264 YKIHSKMGEGTFGQVLECWDKERKEMVAIKVIRGVRKYR---DAAMIEIEMLQQLGrhdigGNRCVQIRNWFDYRNHICIVFEKLG-PSLYDFLRknNYRSFHIDLVREIGRQLLECVAFMHDLHLIHTDLKPENILLVSseyikvpdykgstrslrdacyrripkSSAIKVIDFGSTTYDKQGQ--TYTVSTRHYRAPEVILGLGWSYPCDIWSVGCILIELCSGEALFQTHE-------NLEHLAMMERVLGplpqdMLKRADRH---AekyvrrgrldwpegatsrdsikavlklprlqnlvmqhvdhsAGDFIHLLQGLLRYDPSERFSAREALKHPFF y+ ++k+GeG+fG+V+++ +ke++++vA+K+i+ ++ ++++ Ei++l++l ++ v++ ++f +++++v+e + +l d+l+ + s+ + +++i +q+le ++++H+ ++iH DlKpeNiL+ + ++ +K++DFG + ++++ t v tr+Y+APEv+ + + s ++D+Ws+G+il+el +g+ +f+ ++ +l++l ++ ++lg k + ++ ++++ll+ ll++dp++R++a+e+l+hp++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklk.....hpnivrlyevfeekdelylvleyveggeladlls..rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLide..........................kgelKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.....etkeklpeasel.........................................seeakdllkkllkkdpkkRltaeellqhpyl 170.3 3.3e-52 Protein kinase domain 581 Cluster-7752.2-2F PF07714.14 139 374 2 220 KIHSKMGEGTFGQVLECWDK----ERKEMVAIKVIR-GVRKY-RDAAMIEIEMLQQLgRHDiggnRCVQIRNWFDYRNHICIVFEKL-GPSLYDFLRKN-NYRSFHIDLVREIGRQLLECVAFMHDLHLIHTDLKPENILLVSseyikvpdykgstrslrdacyrripkSSAIKVIDFGSTTYDKQGQTYT-----VSTRHYRAPEVILGLGWSYPCDIWSVGCILIELCS-GEALFQTHENLEHLAMME ++++k+GeG+fG+V e+ k +++ va+K+++ + ++ +++ + e++++++l +h+ + v++ + +++++iv+e + g +L +fLrk+ + ++++++ + ++ +q+ + ++++++ +l+H dl N+Ll + ++ +k+ DfG + ++ ++y+ ++ apE++ + D+Ws G +l+E+++ ge +++ +n e l++++ elgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkkl.khp....nivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlse..........................nkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevleklk 75.3 3e-23 Protein tyrosine kinase 581 Cluster-7774.0-1F RLK-Pelle_Extensin 1 106 164 269 FGYVAPEYAMTGHLLVKSDVYSYGVVLLELLSGRKPVDMTQPHGQENLVTWARPLLTSREGLEQLVDPTLAGSYDFNDMAKVAAIASVCVHPEVTHRPFMGEVVQA fGyvaPeyamtGhllvksdvysyGvvllellsGrkPvdm++p+gqenlvtwarPllt+re+le+lvdp+l+g+y+++d+akvaaiasvcv+pe+++rp+mgevvqa fGyvaPeyamtGhllvksdvysyGvvllellsGrkPvdmkrpegqenlvtwarPlltdrekleelvdpslegeyslddlakvaaiasvcvqpeaserplmgevvqa 189.7 5.4e-58 RLK-Pelle_Extensin 298 Cluster-7774.0-1F PF07714.14 3 106 172 259 YVAPEYAMTGHLLVKSDVYSYGVVLLELLS-GRKPvdmtqphgqenlvtwaRPLLTSREGLEQLvDPTLAGSYDFNDMAKVAAIASVCVHPEVTHRPFMGEVVQA ++apE +++++ +ksDv+s+Gv+l E+++ g++p p l+++e le+l + + + ++++ + + C++ + ++Rp + e+v+ WmapEslkekkftsksDvWsfGvllwEiftlgeep................ypglsneevlekl.kegkrlekpekcpeelyelmkqCweedpeeRptfkelvek 30.1 1.8e-09 Protein tyrosine kinase 298 Cluster-7776.0-0R RLK-Pelle_LRR-II 88 355 1 269 KHILGKGGFGIVYKGSLNDGTVVAVKRLKDYNAIGGEIQFQTEVETISLAVHRNLLRLWGFCSTENERLLVYPYMPNGSVASRLKDHAHGRPVLDWSRRRRIALGTARGLVYLHEQCDPKIIHRDVKAANILLDEDFEAVVGDFGLAKLLDHRDTHVTTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGQKAVDFGRGTHQKGVML-DWVKKLHKDGKLHLMVDKDLKNNFDKVELEEIVQVALLCTHFNPIHRPKMSEVL k ilGkGgfg vykG l+dgt+vavkrlk++++ gge+qfqteve islavhrnllrl Gfc t++erllvypym+ngsvasrl+++ +g+p+ldw++r+rialG+arGl+ylheqcdpkiihrdvkaanillde+feavvgdfglaklld++d+hvttavrGtvGhiapeylstG+ssektdvfG+GilllelitGq+a++++r +++++v+l dwvkkl+k+ kl+ +vdkdlk+++d++e+ee+vqvallct+++p +rpkmsev+ knilGkGgfgkvykGrladgtlvavkrlkeeesaggelqfqtevelislavhrnllrliGfcttsterllvypymengsvasrlrelkegkpaldwetrkrialGaarGlsylheqcdpkiihrdvkaanilldeefeavvgdfglaklldkkdshvttavrGtvGhiapeylstGkssektdvfGyGilllelitGqralelsrlaededvllldwvkklkkekkleklvdkdlkkeydeaeveelvqvallctqvspeerpkmsevv 488.6 3.1e-149 RLK-Pelle_LRR-II 455 Cluster-7776.0-0R PF00069.22 86 356 2 260 SSKHILGKGGFGIVYKGS-LNDGTVVAVKRLKDYNAIGGE-IQFQTEVETISLAVHRNLLRLWGFCSTENERLLVYPYMPNGSVASRLKdhahGRPVLDWSRRRRIALGTARGLVYLHEQCdpkIIHRDVKAANILLDEDFEAVVGDFGLAKLLDHRDThvTTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGQKAVDFGRGTHQKGVMLDWVKKLHKDGKlhlmvDKDLKNNFDKVELEEIVQVALLCTHFNPIHRPKMSEVLR + ++ lG+G+fG Vyk+ ++g vAvK++k +a + ++++E++ + h+n++rl++++++++e++lv y+++g++a++l+ + +l+ ++ ++ia +++gl ylH+++ iiHrD+K +NiL+de+ e ++DFGlak l+++ + +t + gt +APE l++ + s+k+Dv++ G++l+el+tg+ +g++++ +ld ++k+ k + ++++k + ++ ee+ ++ + + +p +R+ ++e+l+ ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls....rkgslseeeakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.....etkeklpeaselseeakdllkkllkkdpkkRltaeellq 150.7 3.2e-46 Protein kinase domain 455 Cluster-7776.0-0R PF07714.14 88 358 4 260 KHILGKGGFGIVYKGSLN-----DGTVVAVKRLKDYNAIGGEIQFQTEVETISLAVHRNLLRLWGFCSTENERLLVYPYMPNGSVASRLKDHAHgRPVLDWSRRRRIALGTARGLVYLHEQcdpKIIHRDVKAANILLDEDFEAVVGDFGLAKLL-DHRDTHVTTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELIT-GQKAvdfgrgthqkgvmldwVKKLhKDGKLHLMVDKDLKNNFDKVELEEIVQVALLCTHFNPIHRPKMSEVLRML ++ lG+G fG V++g+l+ + + vavK lk+ + + +f +e+++++ h+n+++l g+c+ e++ l+v y+++G++ + L+++ + ++ l+ ++ ++al A+G+ yL+++ k++Hrd+ a N+Ll+e+ + ++DfGLa+ + ++ ++++++ + v +apE l++++ ++k+Dv+ fG+ll E++t g++ +++l ++ ++ +++++ + + + ee+ ++ C + +p +Rp+++e+++ l gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkee.kekltlkdllsfalqiAkGmeyLesk...klvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep................ypgl.sneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 145.9 8.7e-45 Protein tyrosine kinase 455 Cluster-782.1101-0R STE_STE7 8 263 1 261 ERISRIGSGSGGTVYKVLHRPTGKFYALKVIHGTHDESVSRQICREIEILRGVDNPNVVKCHNLYDH-NGEIQVLLEYIDKGSLENIHI----SHEPSLSDLTRQVLSGLFYLHKRKIVHRDIKPSNFLINSSGTVKIADFGVSRVLDQTMDaLCNSSVGTIAYMSPERINTDLNhGKYDGYAGDIWSLGVSILEFYLGRFPFAV-SRGGDWASLMCAICMSDPPQAPSTA-SREFRDFITCCLQKDPSKRWPAERLLRHPFI e+++++G+G++g+Vykv hr+t+k+yAlKvi+ +++e+v +qi+re++ilr ++ p+vvkch+++++ +gei+++Ley+d+GsL++++ +ep l++++rqvL+gl yLhkrkivhrdikPsn Lins+g vKIaDFgvs++l+++++ cn++vgt+aYmsPeri+++ + g++++ya+DiWslG+++Le++lGrfP++ ++ dwa+Lm+ai++++pp+ap++a s+efr+F+++clqkd++kR+ ae+Ll+hpF+ ekvkvlGkGasgvVykvrhretskiyAlKvikvnieeavrkqilrelkilreaespsvvkchgvfespsgeisivLeymdgGsLadvlkkkkkipepalaevarqvLkglayLhkrkivhrdikPsnlLinskgevKIaDFgvskilassla.qcntfvgtvaYmsPerieseaa.gesysyaaDiWslGltlLelalGrfPllplgekedwaaLmlaiveeeppeapadafseefrsFvsaclqkdaekRasaeeLlehpFv 364.7 2.3e-111 STE_STE7 339 Cluster-782.1101-0R PF00069.22 8 263 2 264 ERISRIGSGSGGTVYKVLHRPTGKFYALKVIHGTHDESVSR-QICREIEILRGVDNPNVVKCHNLYDHNGEIQVLLEYIDKGSLENIHI----SHEPSLSDLTRQVLSGLFYLHKRKIVHRDIKPSNFLINSSGTVKIADFGVSRVLDQTMDalCNSSVGTIAYMSPERIntdlNHGKYdGYAGDIWSLGVSILEFYLGRFPFAVSRGGD--WASLMC-----AI--CMSDPPQAPSTASREFRDFITCCLQKDPSKRWPAERLLRHPFI e+++++G+Gs G+Vyk++++ tgk +A+K+i ++++ ++ ++ rEi+il+ ++ pn+v++ + + ++ e+ ++ley+++g+l+++ e ++++++q+l+gl ylH+++i+HrD+Kp+N+Li+++g +Ki+DFG+++ l+++ + +s vgt Y++PE + ++ +y + + D+WslGv ++e++ g+ pf+ ++g + ++ l+ i +++ + +s+ s+e++d+++ +l+kdp+kR+ ae ll+hp++ ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvl....keney.skkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 214.6 1e-65 Protein kinase domain 339 Cluster-782.1101-0R PF07714.14 9 257 3 256 RISRIGSGSGGTVYKVLHR----PTGKFYALKVIHGTHDESVSRQICREIEILRGVDNPNVVKCHNLYDHNGEIQVLLEYIDKGSLENIHISH-------EPSLSDLTRQVLSGLFYLHKRKIVHRDIKPSNFLINSSGTVKIADFGVSRVL-DQTMDALCNSSVGTIAYMSPERINTDLnhgkYDgYAGDIWSLGVSILEFYL-GRFPFAVSrggDWASLMCAICMSDPPQAPSTASREFRDFITCCLQKDPSKRWPAERL +++G+G+ G+V++ + + a+K+++ +++e+ ++++++e++i++ +++pn+vk++ ++ +++++ +++ey+++G+L++ ++ +l ++++q+ +G+ yL+++k+vHrd+ N L++++ +vki+DfG++r + ++ +++ + +m+pE +++ + + D+Ws Gv + E + g+ p++ + ++++ ++ + ++p+++++e+ ++++ C+++dp++R ++l lgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekk....ft.sksDvWsfGvllwEiftlgeepypgl...sneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkel 123.8 4.6e-38 Protein tyrosine kinase 339 Cluster-782.111-0F Group-Pl-3 39 154 141 258 VVTFSFDRPLH-RGLAETLCGSPLYMAPEIMQLQKYDAKADLWSVGAILFQIVTGKTPFTGNNQIQLLQNIIKSTELQFPPEA-ENLSPDCVDLCRKLLRRNPVERLTFEEFFNHPYL + f+f r l+ ++laetlcGsplymaPe++qlqkydakadlWsvgailfq+vtG++Pf+Gnn++qllqni+kstel+fp e ++l+pdc+dlcrkllr+npverl+feeff+h++l iadfgfarslqpeelaetlcGsplymaPevlqlqkydakadlWsvgailfqlvtGrpPfsGnnkvqllqnikkstelkfpeeiladlhpdcidlcrkllrknpverlsfeeffahkfl 186.9 2.8e-57 Group-Pl-3 677 Cluster-782.111-0F PF00069.22 51 154 151 264 GL-AETLCGSPLYMAPEIMQLQKYDAKADLWSVGAILFQIVTGKTPFTGNNQIQLLQNIIKS----------TELQfPPEAENLSPDCVDLCRKLLRRNPVERLTFEEFFNHPYL + +++ +g++ Y+APE+++ ++y++k+D+Ws+G il++++tgk+pf g+++ + +++++ t+++ pea++ls+++ dl++kll+++p +Rlt+ee +hpyl sskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkek.lpeaselseeakdllkkllkkdpkkRltaeellqhpyl 81.4 4.5e-25 Protein kinase domain 677 Cluster-782.111-0F PF07714.14 62 148 172 256 YMAPEIMQLQKYDAKADLWSVGAILFQIVT-GKTPFTGNNQIQLLQNIIKSTELQFPpeaENLSPDCVDLCRKLLRRNPVERLTFEEF +mapE+++ +k+ k+D Ws G +l+ i+t g++p++g ++ ++l+++ ++++l+ p e+ +++ +l ++ ++++p eR tf+e WmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevleklkegkrlekp...ekcpeelyelmkqCweedpeeRptfkel 38.1 6.6e-12 Protein tyrosine kinase 677 Cluster-782.112-0R WNK_NRBP 115 369 1 256 NEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHINIMKFYTSWVDTANRNINFVTEMFTSGTLRQYRLRHKRVNIRAVKHWCRQILHGLLYLHSHDPPIIHRDLKCDNIFINGNQGEVKIGDLGLAAILRKSHAVRCV-GTPEFMAPEVYAEEYNELVDIYSFGMCILEMVTFEYPYSECSHPAQIYKKVISGKKPDALYKVEDPEVHRFVEKCLATVAHRLSARELLKDPFL +e+lGkGa+ktvy+afde+eGievaWnqvk+ d+l+spe+lerly+e++llk+lkh ni+k+y+sWvd+ ++++n++te+ftsGtLrqyr +hk+v+++avk+w+rqil+gL yLhs+dPpiihrdlkCdnif+nGn+GevkigdlGlaa+lr+++a ++v GtpefmaPe+y eeynelvdiysfGmc+le+vt+eyPysec+++aqiykkv+sgkkp+al+kv+d+ev++f+ekcla++++rlsa+ellkdpfl kevlGkGavktvykafdeveGievaWnqvkiedvlrspeelerlysevrllkelkhkniiklyasWvdekkktvnlitelftsGtLrqyrkkhkkvdlkavkkwarqilkgLeyLhskdPpiihrdlkCdnifvnGnsGevkigdlGlaavlreakaaksvlGtpefmaPelyeeeynelvdiysfGmcllelvtleyPysecknaaqiykkvtsgkkpaalekvkdaevrkfiekclaeaserlsakellkdpfl 457.4 1.1e-139 WNK_NRBP 801 Cluster-782.112-0R PF00069.22 115 369 4 264 NEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEdlERLYCEIHLLKTLKHINIMKFYTSWVDtaNRNINFVTEMFTSGTLRQYRLRHKRVNIRAVKHWCRQILHGLLYLHSHDppIIHRDLKCDNIFINgNQGEVKIGDLGLAAILRKSH-AVRCVGTPEFMAPEVY-AEEYNELVDIYSFGMCILEMVTFEYPYSECSHPA---QIYKK------VI-SGKKPDALYKVEDPEVHRFVEKCLAT-VAHRLSARELLKDPFL +e lG+G++ +Vy+a+++ +g +vA ++k + ++ e +++ Ei++lk+lkh ni+++y ++ + ++++ +v+e+ g+l ++ r++ ++ + +k++++qil+gl ylHs+ iiHrDlK +Ni+i+ ++ge+Ki+D+Gla+ l++s+ + vgt+e++APEv ++ey + vD++s G+ ++e++t + p+s+ ++ +++++ ++ k+ + + ++e+ ++++k+l+ +Rl+a+ell++p+l leklGeGsfGkVykaveketgkivAvKkikkekakkkke..kkvlrEikilkklkhpnivrlyevfee..kdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskg..iiHrDlKpeNiLid.ekgelKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 162.2 9.9e-50 Protein kinase domain 801 Cluster-782.112-0R PF07714.14 115 360 4 253 NEILGKGASKTVYRAFDE----YEGIEVAwnqVKLYDFLQSPEDLERLYCEIHLLKTLKHINIMKFYTSWVdtANRNINFVTEMFTSGTLRQYRLRH---KRVNIRAVKHWCRQILHGLLYLHSHDppIIHRDLKCDNIFINGNQgEVKIGDLGLAAIL----RKSHAVRCVGTPEFMAPEVYA-EEYNELVDIYSFGMCILEMVT-FEYPYSECsHPAQIYKKVISGKKPDALYKVeDPEVHRFVEKCLAT-VAHRLSA ++ lG+Ga +V+++ + + ++va vK + ++ e+ e++ e++++k+lkh ni+k++ + ++++ +vte+ ++G+L+++ ++ ++++++ + ++++qi +G+ yL+s++ ++Hrdl + N++++ n+ vki+D GLa + + ++ ++ ++mapE+ +++++ D++sfG+++ E++t e py+++ +++++++k+ +gk+ ++ k+ +e+++++++C+++ ++R + gkklGeGafGeVvegtlkgekekkevkva...vKtlkeeateeekeefleeakimkklkhpnivkllgvct..keepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskk..lvHrdlaarNvLlsenk.vvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypgl.sneevleklkegkrlekpekc.peelyelmkqCweedpeeRptf 111.8 2.2e-34 Protein tyrosine kinase 801 Cluster-782.117-0R RLK-Pelle_PERK-1 147 415 2 270 NLLGQGGFGYVHRGVLPNGKEVAVKQLKAGSGQGEREFQAEVEIISRVHHKHLVSLVGYCITGTHRLLVYEFVPNNTLEFHLHGKGRPTMDWPARLKIALGAAKGLAYLHEDCHPKIIHRDIKASNILLDFNFEAKVADFGLAKFSSDANTHVSTRVMGTFGYLAPEYASSGKLTEKSDVFSFGVMLLELITGRRPVDSSQTYMDDSLVDWARPLLTRALEDGNFDSLVDSRLQNDHNHNELASMVACAAACVRHSARRRPRMSQVVRA nllG+GGfGyv++Gvl++gkevavkqlkagsgqGeref+aeveiisrvhh+hlvslvGyci++++rllvyefvpn+tle+hlhgk++p++dw +rlkialgaakglaylhedchPkiihrdika+nilld +feakvadfGlak++sd+nthvstrvmGtfGylaPeyassGklt+ksdvfsfGv+llelitGr+pvd+s++++++slv+warpll++ale+g+fd+lvd+rl+++++++ela m+++aaa+vrhsa++rp+msqvvra nllGeGGfGyvykGvladgkevavkqlkagsgqGerefkaeveiisrvhhrhlvslvGyciaeeqrllvyefvpnktlelhlhgkekpvldwetrlkialgaakglaylhedchPkiihrdikaanilldekfeakvadfGlaklasdtnthvstrvmGtfGylaPeyassGkltdksdvfsfGvvllelitGrkpvdaseelaeeslvewarpllakaleegdfdelvdkrlekkydekelarmieaaaaavrhsakkrpkmsqvvra 520.7 5e-159 RLK-Pelle_PERK-1 597 Cluster-782.117-0R PF07714.14 147 416 5 260 NLLGQGGFGYVHRGVLP-----NGKEVAVKQLKAGSGQG-EREFQAEVEIISRVHHKHLVSLVGYCITGTHRLLVYEFVPNNTLEFHLHGK-GRPTMDWPARLKIALGAAKGLAYLHEDchpKIIHRDIKASNILLDFNFEAKVADFGLAKFS-SDANTHVSTRVMGTFGYLAPEYASSGKLTEKSDVFSFGVMLLELIT-GRRPvdssqtymddslvdwarpllTRALEDGNFDSLVDSRLQNDHNHNELASMVACAAACVRHSARRRPRMSQVVRAL + lG+G fG V++g l + +vavK+lk+++ + ++ef e++i+++++h+++v+l+g c+ + + l+v e+v++++L+ +L+ k +++++ l++al AkG++yL++ k++Hrd+ a N+Ll+ n +k++DfGLa+ +d +++++++ + ++apE +++k+t+ksDv+sfGv+l E++t g++p + l++ ++ + ++++ + +++++ +++ C+++++++Rp+++++v+ l kklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLesk...klvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep....................ypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 163.4 3.8e-50 Protein tyrosine kinase 597 Cluster-782.117-0R PF00069.22 145 412 3 258 NANLLGQGGFGYVHRGV-LPNGKEVAVKQLKAGSGQGERE--FQAEVEIISRVHHKHLVSLVGYCITGTHRLLVYEFVPNNTLEFHLHGKGRpTMDWPARlKIALGAAKGLAYLHEDChpkIIHRDIKASNILLDFNFEAKVADFGLAKFSSDANThvSTRVMGTFGYLAPEYASSGKLTEKSDVFSFGVMLLELITGRRPVDSSQTYM--DDSLVDwaRPLLTRALEDGNFDSLVDSRLqndhnhneLASMVACAAACVRHSARRRPRMSQV + + lG+G+fG V ++v +gk+vAvK++k + + ++e +++E++i+ +++h+++v l++++ + ++++lv e+v++++l+ +l+ kg ++ a+ kia ++gl+ylH+ + iiHrD+K +NiL+d + e K++DFGlak + ++ t ++gt YlAPE ++ + ++k+Dv+s Gv+l+el+tg+ p ++++ l + +++ l++ ++++ ++s l ++ +++ ++R+ ++++ kleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgs.lseeeak.kiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldq..lekilkilgetkeklpeasel........seeakdllkkllkkdpkkRltaeel 153.1 6.1e-47 Protein kinase domain 597 Cluster-782.118-0R RLK-Pelle_PERK-1 147 238 2 93 NLLGQGGFGYVHRGVLPNGKEVAVKQLKAGSGQGEREFRAEVEIISRIHHRHLVSLVGYCISEHQRLLVYDYVPNDTLDYHLHGEGRPVMEW nllG+GGfGyv++Gvl++gkevavkqlkagsgqGeref+aeveiisr+hhrhlvslvGyci+e+qrllvy++vpn+tl++hlhg+++pv++w nllGeGGfGyvykGvladgkevavkqlkagsgqGerefkaeveiisrvhhrhlvslvGyciaeeqrllvyefvpnktlelhlhgkekpvldw 173.5 3.8e-53 RLK-Pelle_PERK-1 238 Cluster-782.118-0R PF07714.14 147 231 5 95 NLLGQGGFGYVHRGVLP-----NGKEVAVKQLKAGSGQG-EREFRAEVEIISRIHHRHLVSLVGYCISEHQRLLVYDYVPNDTLDYHLHGE + lG+G fG V++g l + +vavK+lk+++ + ++ef e++i+++++h+++v+l+g c++e++ l+v +yv++ +L+ +L+ + kklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk 54.0 9.7e-17 Protein tyrosine kinase 238 Cluster-782.118-0R PF00069.22 145 230 3 91 NANLLGQGGFGYVHRGV-LPNGKEVAVKQLKAGSGQGERE--FRAEVEIISRIHHRHLVSLVGYCISEHQRLLVYDYVPNDTLDYHLHG + + lG+G+fG V ++v +gk+vAvK++k + + ++e +++E++i+ +++h+++v l++++ ++++++lv +yv++++l+ +l+ kleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsr 47.1 1.3e-14 Protein kinase domain 238 Cluster-782.1303-2R RLK-Pelle_RLCK-VIII 168 442 1 275 ALIGEGSYGRVYFAQLNDGKEVAVKKLDVSTEQDSNVEFLTQVSMVSRLKHENLVELFGYCVDGNLRVLAYEFATMGSLHDILHGRKGVQGAQPGPVLDWMQRVRIAVDAARGLEYLHEKVQPSIIHRDIRSSNILLFEDYKAKIADFNLSNQAPDNAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQQSLVTWATPRLSEDKVKQCVDPKLKGEYPPKGVAKLAAVAALCVQYEAEFRPNMSIVVKAL +liGeGsygrvy+a+l+dgk++avkkld s+e++sn+efl+qvs+vsrlkhenlvel+gycv+g+lrvlayefat+gslhdilhGrkgv+gaqpgpvl+w+qrv+iav+aarGleylhekvqP++ihrdirssn+llf+d+kakiadfnlsnqapd+aarlhstrvlgtfgyhapeyamtGqltqksdvysfGvvllelltGrkpvdht+prgqqslvtwatprlsedkvkqcvdpklk+eyppk+vaklaavaalcvqyea+frpnmsivvkal sliGeGsygrvyyavlkdgkaaavkkldkskeeesneeflaqvsvvsrlkhenlvellgycvegelrvlayefatkgslhdilhGrkgvkgaqpgpvlsweqrvkiaveaarGleylhekvqPavihrdirssnvllfdddkakiadfnlsnqapdmaarlhstrvlgtfgyhapeyamtGqltqksdvysfGvvllelltGrkpvdhtlprgqqslvtwatprlsedkvkqcvdpklkdeyppkavaklaavaalcvqyeadfrpnmsivvkal 559.0 1.1e-170 RLK-Pelle_RLCK-VIII 611 Cluster-782.1303-2R PF07714.14 169 442 6 260 LIGEGSYGRVYFAQLN-----DGKEVAVKKLDVSTEQDSNVEFLTQVSMVSRLKHENLVELFGYCVDGNLRVLAYEFATMGSLHDILHGRkgvqgaQPGPVLDWMQRVRIAVDAARGLEYLHEKVqpsIIHRDIRSSNILLFEDYKAKIADFNLSNQAPDNAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLT-GRKPvdhtmprgqqslvtwaTPRLSEDKVKQCVDPKLKGEYPPKGVAKLAAVAALCVQYEAEFRPNMSIVVKAL +GeG++G+V+ ++l+ + +vavK+l+ +++++++ efl+++++ ++lkh+n+v+l g c++++ ++ e+++ G+L++ L+ + + + l+ + +++a++ A+G+eyL++k ++Hrd+++ N+Ll e+ ++ki+Df L+++ ++ ++++ + + apE +++++t+ksDv+sfGv+l E++t g++p p+ls+ +v + ++ + + e p k ++l+ + C+++++e Rp+++ +v+ l klGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk......eekekltlkdllsfalqiAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep................ypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 162.3 8.8e-50 Protein tyrosine kinase 611 Cluster-782.1303-2R PF00069.22 167 380 4 204 KALIGEGSYGRVYFAQ-LNDGKEVAVKKLDVSTEQDSNV-EFLTQVSMVSRLKHENLVELFGYCVDGNLRVLAYEFATMGSLHDILHgR-KGVQGAqpgpvldwmQRVRIAVDAARGLEYLHEKVqpsIIHRDIRSSNILLFEDYKAKIADFNLSNQAPDNAArlhSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRG + +GeGs+G+Vy a ++gk+vAvKk++++ +++++ ++l+ ++++ +lkh+n+v+l++++ + + ++l e++ g+l+d+l+ r + ++ + + +ia ++gleylH+k iiHrD+ ++NiL+ e+ + Ki+DF l++++ + t + gt Y APE + + ++k+Dv+s Gv+l+elltg+ p ++ + leklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls.rkgslsee.........eakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgke 141.5 2e-43 Protein kinase domain 611 Cluster-782.1306-2F CAMK_AMPK 1 77 94 170 GRLQEHEARHFFQQIISGVEYCHRNMVVHRDLKPENLLLDSRGNVKLADFGLSNIMRDGHFLRTSCGSPNYAAPEVV grl+e+ear++fqqiisgveychrnmvvhrdlkpenlllds+ nvk+adfglsn++rdg+fl+tscgspnyaapev+ grlkedearrlfqqiisgveychrnmvvhrdlkpenllldsklnvkiadfglsnvlrdgkflktscgspnyaapevi 155.6 9.2e-48 CAMK_AMPK 77 Cluster-782.1306-2F PF00069.22 3 77 95 169 LQEHEARHFFQQIISGVEYCHRNMVVHRDLKPENLLLDSRGNVKLADFGLSNIMRDGHFLRTSCGSPNYAAPEVV l+e+ea+++++qi++g+ey+H++ ++HrDlKpeN+L+d++g++K++DFGl++ ++ ++ l++ +g+++Y APEv+ lseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtreYlAPEvl 100.1 8.8e-31 Protein kinase domain 77 Cluster-782.1306-2F PF07714.14 3 76 101 177 LQEHEARHFFQQIISGVEYCHRNMVVHRDLKPENLLLDSRGNVKLADFGLSNIM-RDGHF-LRTSC-GSPNYAAPEV l+ ++ +f +qi +G+ey +++ +vHrdl N Ll+++ vk++DfGL++ + +d + ++++ + ++ apE+ ltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEs 48.8 3.6e-15 Protein tyrosine kinase 77 Cluster-782.1339-0R CMGC_MAPK 1 169 124 288 YHRDLKPKNILANANCKLKICDFGLARVAfndTPTTIFWTDYVATRWYRAPELCGSfFSKYTPAIDIWSIGCIFAEVLTGKPLFPGKNVVHQLDLITDLLGTPSMDTISRVRNEKARRYLTSMRKKQPVPFAQKFPNADPLALRLLERLLAFDPKDRPRAEEALADPYF +hrDlkpkn+l+nancklkicDfGlar+a +++t ++t+yv+trwyraPel+ s +skYt+aiD+Ws+GCifae+lt+kplfpgk+vv+ql+lit+l+Gtps++++++vr+ekarryl++++kk+++++++kfp++d+lal+LlerllafdPk+r+ aeeala+py+ lhrDlkpknlllnancklkicDfGlarsa...ssetdllteyvvtrwyraPellls.sskYtsaiDvWsvGCifaelltrkplfpgkdvvdqlkliteliGtpseedlesvrsekarrylkklpkkakkslkkkfpkvdelaldLlerllafdPkkritaeealahpyl 263.9 1.2e-80 CMGC_MAPK 511 Cluster-782.1339-0R PF00069.22 2 169 121 264 HRDLKPKNILANANCKLKICDFGLARVAFNDTPttifWTDYVATRWYRAPELCGSffSKYTPAIDIWSIGCIFAEVLTGKPLFP---GKN----VVHQLDLITDLLGtpsmdtI-----SR---VrnekarryltsmrkkqpvpfaqkfpnaDPLALRLLERLLAFDPKDRPRAEEALADPYF HrDlKp+NiL + + +lKi+DFGla+ + ++++ t++v+tr+Y+APE+ ++ ++y++++D+Ws+G+i++e+ltgkp+f+ gk+ ++ql i+++lg + + ++ a++ll++ll+ dpk+R+ aee+l++py+ HrDlKpeNiLidekgelKitDFGlakelesssk....ltsfvgtreYlAPEvlke..neyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg......etkeklpeasel...........................seeakdllkkllkkdpkkRltaeellqhpyl 118.1 2.8e-36 Protein kinase domain 511 Cluster-782.1339-0R PF07714.14 2 88 127 211 HRDLKPKNILANANCKLKICDFGLARVAFNDTPTTIFWTDYVATRWYrAPELCgsFFSKYTPAIDIWSIGCIFAEVLT-GKPLFPGKN Hrdl +N+L + n + ki+DfGLar +d ++ ++ + +W+ apE + +k+t + D+Ws G + E++t g+ +pg + HrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWm.apEsl..kekkftsksDvWsfGvllwEiftlgeepypgls 46.9 1.3e-14 Protein tyrosine kinase 511 Cluster-782.1493-1R CMGC_CDK-CRK7-CDK9 2 106 182 285 AVDMWSVGCIFAELLHGKPIFPGKDEPEQLNKIFELCGAPNEDIWPGVSKiPWYNNLKPSRQMKRRLREVFRHFDRHALDLLDKMLTLDPSQRISAKDALDAEYF avd+WsvGci+aell+gkpi+pG++e eql+kif+lcG+P+e++W+ v++ p+++++kp++++krrl+e+f++++++al+ll+k+l+ldP++r++akdal++e+f avdlWsvGcilaellagkpilpGrteveqlhkifklcGsPseeyWkkvkl.platsfkpqkpykrrlketfkelsesalellekllsldPekrgtakdalkseff 144.9 2e-44 CMGC_CDK-CRK7-CDK9 374 Cluster-782.1493-1R PF00069.22 2 106 177 264 AVDMWSVGCIFAELLHGKPIFPGKDE-------PEQLNKIFELCGaPNEDIWPGVSKIpwynnlkpsrqmkrrlrevfrhfDRHALDLLDKMLTLDPSQRISAKDALDAEYF +vD+Ws+G+i++ell gkp+f+g+++ +ql ki+++ g +++ +p s++ +++a+dll+k+l+ dp++R++a+++l+ +y+ kvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.etkeklpeasel.......................seeakdllkkllkkdpkkRltaeellqhpyl 54.1 9.6e-17 Protein kinase domain 374 Cluster-782.1532-1F CK1_CK1-Pl 196 457 1 260 YRIERKLGKGGFGQVYVGRRINPpnLNERTGPGAIEVALKFEHQSSKGCNYGPPYEWQVYGALGGSHGIPRVHYKGRQGDYYIMVMDMLGPSLWDVWNNSSHTMSIEMVACIAIEAISILEKLHSRGYVHGDVKPENFLLGPPGTPEEKKLFLVDLGLATRWRDTSSGLHVDYDQRPDIFRGTVRYASVHAHLGRTGSRRDDLESLAYTMIFLLRGRLPWQGFQGDNKGFLVCKKKMATSPESLCCFCPAPFKQFVEYVVNL y++erklgkggfgqvyvgrr++ ++rtg+ a+evalkfeh+sskgcnygppyewqvy +lgg++g+p+vhykgrqgdyyi+vmd+lgpslwdvwn+s++++s emvacia+eaisileklh++gyvhgdvkpenfllg+pgt+eekklflvdlgla++w+d++sg hv+ydqrpd+frgtvryasvhahlgrtgsrrddleslayt+ifllrgrlpwqg+qgdnkgflvckkkmatspeslc+++p++f++fve+vvnl ykverklgkggfgqvyvgrrvss..akdrtgadalevalkfehrsskgcnygppyewqvyntlggvygvpkvhykgrqgdyyilvmdllgpslwdvwnssgqalseemvaciaveaisileklhakgyvhgdvkpenfllgqpgtaeekklflvdlglaskwkdaasgqhveydqrpdvfrgtvryasvhahlgrtgsrrddleslaytlifllrgrlpwqgyqgdnkgflvckkkmatspeslcalapqafrefvevvvnl 535.5 1.5e-163 CK1_CK1-Pl 878 Cluster-782.1532-1F PF00069.22 196 430 1 212 YRIERKLGKGGFGQVYVGRRINppnlneRTGpgaiEVALKFEHQSSKGCNY--GPPYEWQVYGALGgSHGIPRVHYKGRQGDYYIMVMDMLG-PSLWDVWNnSSHTMSIEMVACIAIEAISILEKLHSRGYVHGDVKPENFLLGPPGTpeekkLFLVDLGLATRWRDTSSglhvdydqrPDIFRGTVRYASVHAHLGRTGSRRDDLESLAYTMIFLLRGRLPWQGFQGDNKGFLVCKK y+ ++klG+G+fG+Vy +++ + + +vA+K ++++ + E ++ l + i r+ + ++ d++++v++++ +l+d+ + + ++s e + ia + ++ le lHs+g +H D+KpeN+L+ g l ++D+Gla++++ +s+ + f gt +Y + ++ s+ D+ sl+ +++ ll g+ p++g +g++k +++ yekleklGeGsfGkVykaveke......tgk....ivAvKkikkekakkkkekkvlrEikilkklk.hpnivrlyevfeekdelylvleyveggeladlls.rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekge.....lKitDFGlakelesssk.........ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldq 54.1 9.3e-17 Protein kinase domain 878 Cluster-782.1532-1F PF07714.14 198 360 3 157 IERKLGKGGFGQVYVGRRINppnlneRTGPGAIEVALKFEHQSSKG-CNYGPPYEWQVYGALgGSHGIPRVHYKGRQGDYYIMVMDML-GPSLWDVWNNS--SHTMSIEMVACIAIEAISILEKLHSRGYVHGDVKPENFLLGPpgtpeEKKLFLVDLGLATRWRDT +++klG+G fG+V+ g+ + ++ ++va+K +++++ + e ++ +l + i +++ +++ +++v++++ g +L + +++ +++++++ + ++a++ + +e L+s+ +vH d+ N Ll +k+ + D GLa + +++ lgkklGeGafGeVvegtlkg......ekekkevkvavKtlkeeateeekeefleeakimkkl.khpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlse.....nkvvkisDfGLardiekd 24.3 1.1e-07 Protein tyrosine kinase 878 Cluster-782.157-1F AGC_NDR 1 197 99 252 DEARFYVGETVLAIESIHKHNYIHRDIKPDNLLLDKNGHMKLSDFGLCKPLDCSniqekdfsagnkysgalqsdgrpakpkrtqqeqlqhwqrnrrmLAYSTVGTPDYIAPEVLLKRGYGMECDWWSLGAIMYEMLVGYPPFYSDEPMSTCRKIVNWRTHLKFPEEAKISAEAKNLICKLLCNVEQRLGTRGVDEIK dearfyv+e+vlaiesihkhnyihrdikpdnllldk+gh+klsdfglckpld++ laystvgtpdyiapevllk+gygmecdwwslgai+yemlvgyppfysd+p++tcrkivnwrt+lkfp+eak+s+eak+li++llc+ve+rlgt+g++eik dearfyvaesvlaiesihkhnyihrdikpdnllldkeghlklsdfglckpldak...........................................laystvgtpdyiapevllkkgygmecdwwslgailyemlvgyppfysddplttcrkivnwrtllkfpdeaklskeakdlisrllcdvekrlgtkgaeeik 315.4 1.8e-96 AGC_NDR 447 Cluster-782.157-1F PF00069.22 2 189 99 254 EARFYVGETVLAIESIHKHNYIHRDIKPDNLLLDKNGHMKLSDFGLCKPLDCSNIqekdfsagnkysgalqsdgrpakpkrtqqeqlqhwqrnrrmlAYSTVGTPDYIAPEVLLKRGYGMECDWWSLGAIMYEMLVGYPPFYSDEPMS----TCRK------IVNwRTHLKFPEEAKISAEAKNLICKLLCN-VEQRLG ea++++ +++ ++e +H+++ iHrD+Kp+N+L+d++g++K++DFGl+k l+ s+ + s vgt++Y+APEvl +++y+ ++D+WslG i+ye+l g ppf++++ + +++ i++ t++k+pe+ ++s eak+l+ kll+ ++Rl+ eakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk..........................................ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.etkeklpeaselseeakdllkkllkkdpkkRlt 121.4 2.8e-37 Protein kinase domain 447 Cluster-782.157-1F PF07714.14 13 51 116 154 AIESIHKHNYIHRDIKPDNLLLDKNGHMKLSDFGLCKPL ++e +++++++Hrd+ N Ll++n ++k+sDfGL++ + GmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardi 31.3 8.2e-10 Protein tyrosine kinase 447 Cluster-782.157-1F PF07714.14 105 168 169 232 TPDYIAPEVLLKRGYGMECDWWSLGAIMYEMLV-GYPPFYSDEPMSTCRKIvNWRTHLKFPEEAK ++apE+l ++ + + D Ws G +++E++ g p+ + +++++++k+ + +++l+ pe+++ pvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevlekl.kegkrlekpekcp 23.1 2.5e-07 Protein tyrosine kinase 447 Cluster-782.1570-2R TKL-Pl-6 3 222 35 253 DRLIADFWKEALILSSLHHPNVVSFYGVVRDGPDGSLATVTEFMVNGSLKQFLQKKDRTIDRRKRLIIAMDAAFGMEYLHGKNIVHFDLKCENLLVNMRDPHRPVCKIGDLGLSKVKQHTLVSGGVRGTLPWMAPELLSgKSNMVTEKIDVYSFGIVMWELLTGDEPYADMHCATIIGGIVNNTLRPQIPTWCDPEWKALMESCWASDPAQRPSFSEISQ ++l+++f++ea ils+L+hpnvv++yGvv+dgp+gslatvtef++ngsl+++l+kkdr++drrkr++ia+daa+GmeYLh k++vhfdLk++nLLv++r+p+rp+ck++D+GLsk+k++tlvsggvrGtLPwmapell+ +s++v+ek+DvysfGiv+Welltg+ePya++++++i++giv+++lrp++P++cdpeW++Lme+Cwa++pa+rPsf+e+++ eklvseflseaeilskLrhpnvvalyGvvkdgpggslatvteflrngslrsvlskkdrkldrrkrilialdaalGmeYLhskavvhfdLktdnLLvdlrepqrpickvaDfGLskikretlvsggvrGtLPwmapellr.sskevsekvDvysfGivlWelltgeePyaslnlgaillgivkeelrpavPescdpeWreLmeaCwapepaarPsftevae 385.2 1.2e-117 TKL-Pl-6 420 Cluster-782.1570-2R PF07714.14 6 224 45 260 IADFWKEALILSSLHHPNVVSFYGVVRdgPDGSLATVTEFMVNGSLKQFLQKK--DRTIDRRKRLIIAMDAAFGMEYLHGKNIVHFDLKCENLLVNMrdphRPVCKIGDLGLSKVK---QHTLVSGGVRGTLPWMAPELLSGKSnmVTEKIDVYSFGIVMWELLT-GDEPYADMHCATIIGGIvNNTLRPQIPTWCDPEWKALMESCWASDPAQRPSFSEISQKL ++f +ea i+++l+hpn+v+++gv+ +++l vte++ +G+L++fL+kk +++++ ++ l +a++ A GmeyL+ k++vH dl + N L++ + v+ki+D GL++ +++ ++++ + + WmapE l+ k+ +t+k Dv+sfG+++wE++t g+epy++++ ++++ + ++ r + p+ c +e++ lm++Cw++dp++Rp+f+e+ +kl keefleeakimkklkhpnivkllgvct..keepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlse....nkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekk..ftsksDvWsfGvllwEiftlgeepypglsneevlekl.kegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 190.6 1.9e-58 Protein tyrosine kinase 420 Cluster-782.1570-2R PF00069.22 8 222 44 260 DFWKEALILSSLHHPNVVSFYGVVRDgpDGSLATVTEFMVNGSLKQFLQkKDRTIDRRKRLIIAMDAAFGMEYLHGKNIVHFDLKCENLLVNmRDPHrpvCKIGDLGLSKVKQHTLVSGGVRGTLPWMAPELLsgKSNMVTEKIDVYSFGIVMWELLTGDEPYADMHCAT----IIGG------IV-NNTLRPQIPTWCDPEWKALMESCWASDPAQRPSFSEISQ ++++E il +l+hpn+v +y+v+++ + +l v+e++ +g+l+++l+ ++ +++ ++ ia + g+eylH k+i+H DlK eN+L++ ++ + Ki+D+Gl+k +++ + gt ++APE+l k+n++++k+Dv+s G++++elltg +p+++ + + ++ i+ ++++ + ++ +++e k l++++++ dp +R++++e+ q kvlrEikilkklkhpnivrlyevfee..kdelylvleyveggeladlls.rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLid.ekge...lKitDFGlakelessskltsfvgtreYlAPEvl..keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellq 143.5 4.8e-44 Protein kinase domain 420 Cluster-782.1577-1R RLK-Pelle_SD-2b 284 550 2 267 HLLGTGGFGSVYKGTLRDGALIAVKKLDRVlSHGEKEFITEVNTISSMHHVNLVRLCGYCSEGSQRLLVYEFMKNGSLDKWIFpsHNSRERLLDWSTRFLVALGTAQGIAYFHEQCRDRIIHCDIKPENILLDENFCPKVSDFGLAKLMGREHSHVVTMVRGTRGYLAPEWVSNRPITVKADVYSYGMLLLEIIGGRRNLDM--TFDSEGFFYPGWAFKELANGAPTKVADRRLEGAVEEEELVRALKVAFWCIQDEISMRPTMGEVVK + lG+GgfgsVykg+l+d+ +avKkl++v ++gekef +ev++i+s++hvnLvrl+G+cseg++rllvye+++ngsLdk++f +++++++l+w+tr+ +alg+A+g+ay+He+cr++iihcdikpeniLlde+f+pk++dfGlakl++r++s+v+t vrGtrgYlapew+sn++it k+DvYsyG++lle++ grrn+++ + ++e ++++ +a+++l +g +++ d+rleg+v++ee+ r++kva+wciq++ s+RP+m evvk eklGeGgfgsVykgvledetkvavKklekv.eqgekefraevsvigsiqhvnLvrllGfcsegekrllvyeyvengsLdkllf..kkkskkvlewktrlkialgvArglayLHeecrekiihcdikpeniLldekfepkiadfGlakllkrdqsrvlttvrGtrgYlapewisnlaitekvDvYsyGvvllelvsgrrnveekeseeeesvllvklaaekleegevaelvdarlegevdleevervvkvalwciqedeskRPsmsevvk 387.6 2.1e-118 RLK-Pelle_SD-2b 674 Cluster-782.1577-1R PF00069.22 283 484 4 198 SHLLGTGGFGSVYKGT-LRDGALIAVKKLDRVLSHGEKE--FITEVNTISSMHHVNLVRLCGYCSEGSQRLLVYEFMKNGSLDKWIFpshnsRERLLDWSTRFLVALGTAQGIAYFHEQCrdrIIHCDIKPENILLDENFCPKVSDFGLAKLMGREHShvVTMVRGTRGYLAPEWVSNRPITVKADVYSYGMLLLEIIGGRRNLD + lG+G+fG+Vyk++ ++g +AvKk+++ +ke +++E++ + +++h n+vrl ++++e ++++lv e++++g+l++++ r+ l+ ++ +a +++g++y H+++ iiH+D+KpeNiL+de+ K++DFGlak + ++++ +t + gtr YlAPE++++++++ k+Dv+s+G++l+e++ g+ + leklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls.....rkgslseeeakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfs 156.6 5e-48 Protein kinase domain 674 Cluster-782.1577-1R PF07714.14 282 551 3 259 FSHLLGTGGFGSVYKGTLR-----DGALIAVKKLDRVLSHG-EKEFITEVNTISSMHHVNLVRLCGYCSEGSQRLLVYEFMKNGSLDKWIfpSHNSRERLLDWSTRFLVALGTAQGIAYFHEQcrdRIIHCDIKPENILLDENFCPKVSDFGLAKLM-GREHSHVVTMVRGTRGYLAPEWVSNRPITVKADVYSYGMLLLEIIG-GRRNldmtfdsegffYPGWAFKELANGAptkvaDRRLEGAVEEEELVRALKVAFWCIQDEISMRPTMGEVVKM +++ lG G fG+V++gtl+ + +avK+l++ ++ ++ef++e++++++++h n+v+l g c+++++ l+v e++++G+L+k + ++++++ l+ ++ + +al A+G++y +++ +++H d+ N+Ll+en + k+sDfGLa+ + +++ ++ + + ++apE ++++ +t+k+Dv+s+G+ll Ei+ g++ ypg+ +e+++ +++ + + e+ + ++ C++ + + Rpt+ e+v+ lgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfL..rkkeekekltlkdllsfalqiAkGmeyLesk...klvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep...........ypglsneevlekl.....kegkrlekpekcpeelyelmkqCweedpeeRptfkelvek 136.3 7.2e-42 Protein tyrosine kinase 674 Cluster-782.1687-0R AGC_RSK-2 254 592 1 258 RLLKRLGCGDIGSVYLAELSGTKCHFAMKVMDKASLAGRKKLLRAQTEREILQSLDHPFLPSLYTHFETEKFSCLVMEFCPGGDLHSLRQRQPGKYFSEQAVKFYVAEVLLALEYLHMLGIVYRDLKPENVLVRDDGHIMLSDFDLSLRCVVSptlvktssltsepprknsaycaqpaciepsciqpscvvptscfsprlfsrkskkdgkpkpkieignqvsplpelmaeptnaRSMSFVGTHEYLAPEIIKGEGHGSAVDWWTFGIFLYELLFGKTPFKGSGNRATLFNVVGQPLRFPESPVVSFAARDLIRGLLVKEPQNRLAYKRGATEIKQHPFF +llk+lG+Gdigsvyl+el+gt+++fa+kv+dk++la rkkl ra++ereil++ldhPflp+ly++fetekf+clv+efcpggdLh+lr+rqp k fse+av+fy+aev+laleylh+lgivyrdLkPenvlvr+dGhiml+DfDLsl++ + rs+sfvGt+eylaPeiikgeghgsavdWW++Gi+lyell+gktPfkg+ +++tl+nv+ ++l+fpe++ vs++ardlir+ll+k+p++rl++krga+eik+hpff kllkklGsGdigsvylvelrgtealfalkvldkealakrkklkraeaereilelldhPflptlyasfetekfvclvvefcpggdLhvlrerqpkkvfseeavrfyaaevvlaleylhalgivyrdLkPenvlvredGhimltDfDLslkasak.................................................................................rsnsfvGteeylaPeiikgeghgsavdWWalGillyellygktPfkgknreetlanvlkkelefpeeaavsleardlirkllekdpkkrlgskrgaaeikkhpff 437.2 1.5e-133 AGC_RSK-2 783 Cluster-782.1687-0R PF00069.22 254 407 2 152 RLLKRLGCGDIGSVYLAELSGTKCHFAMKVMDKASLAGRKKlLRAQTEREILQSLDHPFLPSLYTHFETEKFSCLVMEFCPGGDLHSLRQrqPGKYFSEQAVKFYVAEVLLALEYLHMLGIVYRDLKPENVLVRDDGHIMLSDFDLSLRCVVSP + l++lG G+ G+Vy a + t++++A+K+++k + +k+ ++++E +il++l+hp++ ly fe+++ +lv+e+++gg+l++l + + +se+ +k++++++l +leylH gi++rDlKpeN+L+ ++g+++++DF+l+ + s ekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls..rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesss 127.2 4.7e-39 Protein kinase domain 783 Cluster-782.1687-0R PF00069.22 489 592 154 264 SMSFVGTHEYLAPEIIKGEGHGSAVDWWTFGIFLYELLFGKTPFKGSGNRATLFNVVGQ-----------PLRFPESPVVSFAARDLIRGLLVKEPQNRLAykrgATEIKQHPFF +sfvgt+eYlAPE++k+++++++vD+W+ G+ lyell+gk+pf+g+ ++ + + + q + +pe +s a+dl++ ll k+p++Rl a+e++qhp++ ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRlt....aeellqhpyl 73.2 1.4e-22 Protein kinase domain 783 Cluster-782.1687-0R PF07714.14 255 403 3 154 LLKRLGCGDIGSVYLAELS----GTKCHFAMKVMDKASLAgrKKLLRAQTEREILQSLDHPFLPSLYTHFETEKFSCLVMEFCPGGDLHS-LRQRQPGKYFSEQAVKFYVAEVLLALEYLHMLGIVYRDLKPENVLVRDDGHIMLSDFDLSLRC l k+lG G G+V+ ++l+ ++++ a+K++++ + + ++ + +e +i+++l+hp + +l+ e+ ++v+e+++gGdL++ Lr+++ + ++ + + +++++ ++eyL+ +v rdl NvL++++ ++ +sDf L+ + lgkklGeGafGeVvegtlkgekekkevkvavKtlkeeate..eekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardi 71.1 5.8e-22 Protein tyrosine kinase 783 Cluster-782.1687-0R PF07714.14 495 579 169 253 THEYLAPEIIKGEGHGSAVDWWTFGIFLYELLF-GKTPFKGSgNRATLFNVVGQPLRFPESPVVSFAARDLIRGLLVKEPQNRLAY +++apE++k + s+ D W fG+ l+E++ g++p++g + +++++ + + r ++ ++ + +l++ + ++p++R + pvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypgl.sneevleklkegkrlekpekcpeelyelmkqCweedpeeRptf 26.7 2.1e-08 Protein tyrosine kinase 783 Cluster-782.17-1F RLK-Pelle_RLCK-VIIa-2 78 352 2 275 MLGEGGFGCVFKAAVKNYEDPA----NKLDVAIKQLGRRGLQGHKEWVTEVNVLGVVEHPNLVKLIGYCAEDDergiQRLLVYEYMPNGSVEDHLSGRSGKPLPWSMRLKIAQDAARGLAYLHeEMDFQIIFRDFKSSNILLDDQWNAKLSDFGLARLGPPEGITHVSTAVVGTLGYAAPEYVQSGRLTSKSDVWSYGVFLYELITGRRPMDRNRPRSEQKLLDWVRPHLGDHKKFQLILDPKLDGKPVLKSAHKLSLVANRCLSRVPKSRPKMSEILE +lGeGgfG+v+k+++++ + + ++l+va+k+l ++glqghkew++ev++Lg ++hpnlvkliGyc+edd +rllvyEym++gs+e+hl+ rs ++l+W++rlkia +aA+gla+Lh e++ ++i+Rdfk+sniLld+++naklsdfgla+ gp e+ thvst+v+gt gYaaPeyv++G+lt+ksDv+s+Gv l+el+tGrr +d++rp++eqkl+dw+rp+l d++k++ i+Dp+l+g+ k+a+k++ +a++Cls+ pk+Rpkmse++e llGeGgfGsvykgvidektkaelkageglavavkklnkeglqghkewlaevefLgqlshpnlvkliGycledd....erllvyEymakgslenhlfrrssealsWetrlkialgaAkglafLh.eaekkviyRdfkasniLldedfnaklsdfglakegpeedkthvstrvmgtygYaaPeyvatGhltaksDvysfGvvllelltGrraldkkrpkeeqklvdwarpllsdkrkleriiDprlegqysakaaqkvaklalkClskepkeRpkmsevve 404.0 2.1e-123 RLK-Pelle_RLCK-VIIa-2 468 Cluster-782.17-1F PF00069.22 75 352 3 260 RYTMLGEGGFGCVFKAAVKNyedpaNKLDVAIKQLGRRGLQGHKE--WVTEVNVLGVVEHPNLVKLIGYCAEDDERGiqrlLVYEYMPNGSVEDHLSgRSGKpLPWSMRLKIAQDAARGLAYLHEEMdfqIIFRDFKSSNILLDDQWNAKLSDFGLARLGPPEGIthvSTAVVGTLGYAAPEYVQSGRLTSKSDVWSYGVFLYELITGRRPMDRNRPRS-EQKLLDWvrphlgdHKKFQLIL-DPKLDGKPVLKSAHKLSLVANRCLSRVPKSRPKMSEILE + + lGeG+fG+V+ka k+ ++ vA+K++ ++ + ke ++E+++l ++hpn+v+l++++ e+de+ lv ey+++g+++d+ls r+g+ l+ + kia+ ++gl+ylH++ ii+rD K++NiL+d++ + K++DFGla+ + t +vgt Y APE +++ + ++k+DvWs+Gv lyel+tg+ p+ ++ ++ +k ld ++k++ il + k++ + + +++ + +++l++ pk+R+ ++e+l+ kleklGeGsfGkVykaveke.....tgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdely....lvleyveggeladlls.rkgs.lseeeakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldq.......lekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellq 159.9 5e-49 Protein kinase domain 468 Cluster-782.17-1F PF07714.14 77 352 5 258 TMLGEGGFGCVFKAAVKNyEDPANKLDVAIKQLGRRGLQG-HKEWVTEVNVLGVVEHPNLVKLIGYCAEDDErgiqRLLVYEYMPNGSVEDHLSGR-SGKPLPWSMRLKIAQDAARGLAYLHEEmdfQIIFRDFKSSNILLDDQWNAKLSDFGLARLGPPEGITHVSTAVVGTLGYAAPEYVQSGRLTSKSDVWSYGVFLYELIT-GRRPmdrnrprseqklldwvRPHLGDHKKFQLIlDPKLDGKPVLKSAHKLSLVANRCLSRVPKSRPKMSEILE + lGeG fG V+++ +k+ e+ ++++va+K+l ++ + ++e ++e++++ ++hpn+vkl+g c ++++ l+v ey+++G+++++L + + ++l + l++a++ A+G++yL+++ +++ rd + N+Ll+++ +k+sDfGLar + +++++ + + apE ++++++tsksDvWs+Gv l+E++t g++p p+l +++ ++ + + + + k ++l + ++C+++ p++Rp+++e++e kklGeGafGeVvegtlkg.ekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeep....llivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLesk...klvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep................ypglsneevlekl.kegkrlekpekcpeelyelmkqCweedpeeRptfkelve 159.0 8.7e-49 Protein tyrosine kinase 468 Cluster-782.1740-0R RLK-Pelle_LRR-II 35 269 1 235 KNILGRGGFGKVYKGRLADGSLVAVKRLKEERTPGGELQFQTEVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRERQPNEPPLDWPTRKRIALGSARGLSYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIAPEYLSTGKSSEKTDVFGYGIMLLELITGQRAFDLARLANDDDVMLLDWVKGLLKEKKLEMLVDPDL knilG+GgfgkvykGrladg+lvavkrlkee+++ggelqfqteve+is+avhrnllrl+Gfc+t+terllvypym+ngsvas+lre++ ++p+ldw+trkrialG+arGlsylh++cdpkiihrdvkaanilldeefeavvgdfglakl+d+kd+hvttavrGt+GhiapeylstGkssektdvfGyGi+llelitGqra++l+rla+d+dv+lldwvk l kekkle+lvd dl knilGkGgfgkvykGrladgtlvavkrlkeeesaggelqfqtevelislavhrnllrliGfcttsterllvypymengsvasrlrelkegkpaldwetrkrialGaarGlsylheqcdpkiihrdvkaanilldeefeavvgdfglaklldkkdshvttavrGtvGhiapeylstGkssektdvfGyGilllelitGqralelsrlaededvllldwvkklkkekkleklvdkdl 461.0 8.4e-141 RLK-Pelle_LRR-II 269 Cluster-782.1740-0R PF00069.22 33 237 2 199 SNKNILGRGGFGKVYKGR-LADGSLVAVKRLKEERTPGGEL-QFQTEVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRerqpNEPPLDWPTRKRIALGSARGLSYLHDHCdpkIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDThvTTAVRGTIGHIAPEYLSTGKSSEKTDVFGYGIMLLELITGQRAFDL ++++ lG+G+fGkVyk++ ++g vAvK++k+e++ + ++++E++++ h+n++rl +++ +++e++lv y+ +g++a+ l+ ++ l+ + k+ia ++gl+ylH+++ iiHrD+K +NiL+de+ e ++DFGlak ++ + + +t + gt +APE l++ + s+k+Dv+++G++l+el+tg+ f ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls....rkgslseeeakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsg 151.1 2.5e-46 Protein kinase domain 269 Cluster-782.1740-0R PF07714.14 35 234 4 206 KNILGRGGFGKVYKGRLA-----DGSLVAVKRLKEERTPGGELQFQTEVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRERQpNEPPLDWPTRKRIALGSARGLSYLHDHcdpKIIHRDVKAANILLDEEFEAVVGDFGLAKLM-DYKDTHVTTAVRGTIGHIAPEYLSTGKSSEKTDVFGYGIMLLELIT-GQRA ++ lG+G fG+V++g+l + vavK lkee t + +f +e+++++ h+n+++l g+c+ + l+v y+++G++ + Lr+++ ++++l+ + ++al A+G++yL+++ k++Hrd+ a N+Ll+e+ + ++DfGLa+ + + +++++++ + + +apE l+++k ++k+Dv+ +G++l E++t g++ gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkke.ekekltlkdllsfalqiAkGmeyLesk...klvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep 141.2 2.3e-43 Protein tyrosine kinase 269 Cluster-782.1752-0F IRE1 1 98 128 226 MRDVACGLAYLHRLGLIHLHLEPRHVLIwVKENELRAKISNLGFTTRVGGKQSLFVDH--GFEITGWHHPIEKEQQPFTEAMDLFSLGCILFYCITGGMH mrd+ +Gl++lh+lg++h l+P+ vli +k++ l+ak+s++g++ r++ ++s + d+ g+ +Gw P +++ t a+dlfslGc+lfy+itgg h mrdivaGlvhlhelgivhrdlkPqnvli.skdrtlsaklsdmglskrlaedvsslkdlatgsGssGwqaPeqlkegrqtravdlfslGcllfyaitggkh 87.2 8.5e-27 IRE1 310 Cluster-782.1752-0F PF00069.22 1 95 104 193 MRDVACGLAYLHRLGLIHLHLEPRHVLIWvKENElrAKISNLGFTTRVGGKQSlfvDHGFEITGWHHPIE-KEQQPFTEAMDLFSLGCILFYCITG ++ ++ gl+ylH+ g+iH l p +Li +++e Ki+ +G+ +++ +++ + f +t + + E +++++++++D++slG+il+ +tg akqilegleylHskgiiHrDlKpeNiLid.ekge..lKitDFGlakelesssk...ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltg 36.2 2.6e-11 Protein kinase domain 310 Cluster-782.1752-0F PF07714.14 2 96 111 203 RDVACGLAYLHRLGLIHLHLEPRHVLIwvKEnELRAKISNLGFTTRVGGKQSLFVDHG-FEITGWHHPIEKEQQPFTEAMDLFSLGCILFYCITGG +++A+G++yL++ l+H l r vL+ +e + +kis G + ++ +++ ++++ W p +++ ft++ D +s G +l+ +t g lqiAkGmeyLeskklvHrdlaarNvLl..se.nkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlg 26.6 2.1e-08 Protein tyrosine kinase 310 Cluster-782.1761-2R CMGC_SRPK 80 457 1 305 YIAQRKLGWGQFSTVWLAYDTRSSRYVALKIQKSAPQFAQAAAHEIEVLEAIAEGDPSNTKCVVRLVDHFKHTGPNGQHPCMVLEYLGDSLLRLIKYNRYKGLELNRVREICRCILTGLDYLHRELGIIHTDLKPENILLhstinpskdhtksgkapilekpeggnanggvtinfvekrlkqrarravariserrssmggigappkpprcldgIDLRCKVVDFGNACWADKPFAEEIQTRQYRAPEVILQSGYSFAADMWSFGCTAFELATGEMMFTPKGGQGFSEDEDHLALMMELLGKMPRKVATGGGRSKDYFDRYGDLKRIKRLKCRPLDRFLVDKFNFSDADAREFSKFLSPLLDFEPDKRPTAQQCLQHPWL y++qrklGwG+fstvwlaydt++s+yvalk+qksa ++++aa +eie+l++ia+gd+ ++k+vv+l+dhfkh+gpng+h c+vleylGd+ll+lik+n+ykGl+l+ v+ei+++il+gldylhrel+iihtdlkPenill i+lrckvvd+gnacwadk faeeiqtrqyrapevil+s+ys++ad+wsf+c++felatg+++f pk g++++ededhlal++ellgkmprk+a++g +skdyfdr+gdlkri+rlk pldr l++k+++s+++a+e+++fl+plldf p+krpta++cl+hpwl yvvqrklGwGhfstvwlaydtetskyvalkvqksaqdyteaaldeiellkqiadgdkedekavvklldhfkhagpngkhvclvleylGdnlltlikankykGlplsvvkeiakeilvgldylhrelsiihtdlkPenill.........................................................................ielrckvvdlgnacwadkqfaeeiqtrqyrapevilgskystsadlwsfacvvfelatgdvlfapksgddydededhlalllellgkmprkialsgkkskdyfdrhgdlkrirrlkywpldrlliekyklseeeakeladflvplldfapekrptaaeclkhpwl 554.2 4.9e-169 CMGC_SRPK 745 Cluster-782.1761-2R PF00069.22 82 221 3 133 AQRKLGWGQFSTVWLAYDTRSSRYVALKIQKSAPQFA---QAAAHEIEVLEAIAegdpsnTKCVVRLVDHFKHtgpnGQHPCMVLEYLG-DSLLRLIKynRYKGLELNRVREICRCILTGLDYLHrELGIIHTDLKPENILLHS ++klG G+f++V a+++++++ vA+K+ k + +++++Ei++l+ + + +vrl++ f++ ++ ++vley+ ++l +l++ r + l+ +++++i++ il+gl+ylH + giiH DlKpeNiL+++ kleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklk......hpnivrlyevfee....kdelylvleyveggeladlls..rkgslseeeakkiakqilegleylH.skgiiHrDlKpeNiLide 76.5 1.4e-23 Protein kinase domain 745 Cluster-782.1761-2R PF00069.22 297 457 137 264 CKVVDFGNACWADKP--FAEEIQTRQYRAPEVILQSGYSFAADMWSFGCTAFELATGEMMFT-PKGGQGFSEDEDHLALMMELLGKMPRKVATGGGRskdyfdrygdlkrikrlkcrpldrflvdkfnfsdadAREFSKFLSPLLDFEPDKRPTAQQCLQHPWL K++DFG a+ +++ + +++ tr+Y+APEv+ +++ys ++D+Ws G++ +el tg+++f kg + ++++ d+l ++++lg++ k+++ +e+ ++l+ ll+ +p kR+ta+++lqhp+l lKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeasel....................................seeakdllkkllkkdpkkRltaeellqhpyl 79.3 1.9e-24 Protein kinase domain 745 Cluster-782.1761-2R PF07714.14 83 221 4 139 QRKLGWGQFSTVWLAYDT----RSSRYVALKIQKSAPQF--AQAAAHEIEVLEAIaEgdpsnTKCVVRLVDHFKhtgpNGQHPCMVLEYLGD-SLLRLIKYN-RYKGLELNRVREICRCILTGLDYLHRElGIIHTDLKPENILLHS ++klG G+f++V+ ++ + +++ va+K+ k+ + ++ +e+++++++ + + +v+l+ ++++ ++v+ey+ +Ll+ ++ + + + l+l+++ ++++ i G++yL+++ ++H dl N+Ll++ gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkkl.k.....hpnivkllgvct....keepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLesk.klvHrdlaarNvLlse 35.7 3.5e-11 Protein tyrosine kinase 745 Cluster-782.1761-2R PF07714.14 296 353 142 205 RCKVVDFGNACWA--D---KPFAEEIQTRQYRAPEVILQSGYSFAADMWSFGCTAFELAT-GEM +k+ DfG a d k e+ ++ apE++ ++ ++ ++D+WsfG + +E++t ge+ vvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgee 23.9 1.4e-07 Protein tyrosine kinase 745 Cluster-782.1765-0R CAMK_AMPK 22 121 1 100 YRLGKTLGHGSFGKVKIAEHVQTRYKVAIKILNRRKMKSPDMEEKVRREIKICRLFVHPHVIRLYEVIETPSDIYVVMEYVKHGELFDYIVEKGRLQEHE y+lgktlg+gsf+kvk+aehv+t kvaikilnrrk+k+ ++eekvrreiki rl++hph++rlyevietpsdiyvvmeyvk+gelfdyivekgrl+e+e yklgktlgigsfakvkvaehvltgkkvaikilnrrklkameleekvrreikilrllahphivrlyevietpsdiyvvmeyvksgelfdyivekgrlkede 166.8 3.4e-51 CAMK_AMPK 121 Cluster-782.1765-0R PF00069.22 22 120 1 98 YRLGKTLGHGSFGKVKIAEHVQTRYKVAIKILNRRKMKSPDMeEKVRREIKICRLFVHPHVIRLYEVIETPSDIYVVMEYVKHGELFDYIVEKGRLQEH y+ ++lG GsfGkV a + +t+ +vA+K+++++k+k+ + +kv+rEiki + + hp+++rlyev+e+++++y+v+eyv++gel+d++ +kg l+e+ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslsee 84.7 4.4e-26 Protein kinase domain 121 Cluster-782.1765-0R PF07714.14 24 114 3 95 LGKTLGHGSFGKVKIAEHV----QTRYKVAIKILNRRKMKSPdmEEKVRREIKICRLFVHPHVIRLYEVIETPSDIYVVMEYVKHGELFDYIVEK lgk+lG+G+fG+V ++ ++++kva+K+l+++++++ +e++ +e+ki + + hp++++l+ v+ + +++v+eyv++G+L +++ +k lgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateee..keefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk 63.2 1.4e-19 Protein tyrosine kinase 121 Cluster-782.1791-1F CMGC_GSK 114 395 1 283 AERVVGQGSFGIVFQAKCLESGETVAIKKVLQDKRYKNRELQTIRLLDHPNVVSLKHCFFSTTDKDELYLNLVLEYVPETVYRVTRHYSKANQRMPMIYVKLYTYQIFRALAYIHG-IGVCHRDIKPQNLLVNPHTHQLKLCDFGSAKVLVKGEPNISYICSRYYRAPELIFGATEYTTAIDVWSVGCVLAELLLGQPLFPGESGVDQLVEIIKVLGTPTREEIKCMNPNYTEFKFPQIKAHPWHKIFHKRTPPEAVDLVSRLLQYSPNLRCNALEACIHPFF aervvg+gsfg+vfqakcle+getvaikkvlqdkryknrelq++rlldhpnvv+lkh+ffstt+kdelylnlvleyvpetvyrv++hysk+nqr+p+iyvklytyqi+ralayih +gvchrdikpqnllvnp+thqlklcdfgsakvlvkgepnisyicsryyrapelifgateyttaid+ws+gcvlaelllgqplfpgesgvdqlveiikvlgtptreeikcmnpnytefkfpqikahpwhk+f+kr+ppeavdlvsrllqyspnlrc+alea++hpff aervvgtgsfgvvfqakcletgetvaikkvlqdkryknrelqimrlldhpnvvalkhlffsttekdelylnlvleyvpetvyrvakhysklnqrlpliyvklytyqicralayihkvvgvchrdikpqnllvnpkthqlklcdfgsakvlvkgepnisyicsryyrapelifgateyttaidiwsagcvlaelllgqplfpgesgvdqlveiikvlgtptreeikcmnpnytefkfpqikahpwhkvfkkrlppeavdlvsrllqyspnlrctalealvhpff 616.1 5.5e-188 CMGC_GSK 527 Cluster-782.1791-1F PF00069.22 112 395 1 264 YMAERVVGQGSFGIVFQAKCLESGETVAIKKVLQDKRYKN------RELQTIRLLDHPNVVSLKHCFFSttdKDELYlnLVLEYVPETVyrVTRHYSkANQRMPMIYVKLYTYQIFRALAYIHGIGVCHRDIKPQNLLVNpHTHQLKLCDFGSAKVLVKGEPNISYICSRYYRAPELIfGATEYTTAIDVWSVGCVLAELLLGQPLFP---GES----GVDQLVEIIKVLGtptreE--IKCMNP--NytefkfpqikahpwhkifhkrtPPEAVDLVSRLLQYSPNLRCNALEACIHPFF y ++ +G+GsfG V++a+ e+g++vA+Kk+ ++k+ k+ rE++ ++ l+hpn+v l+++f + kdely lvleyv+++ +++++s +++ +++ +k +++qi+++l+y+H g++HrD+Kp+N+L++ ++ +lK++DFG ak l ++++ s++++r+Y+APE++ +++ey++++DvWs+G++l+ell g+p+f+ g++ +dql++i+k+lg e k ++ ++ea dl+++ll++ p+ R+ a e++ hp++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee...kdely..lvleyvegge..ladlls.rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLid.ekgelKitDFGlakelessskltsfvgtreYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.....etkeklpeasel......................seeakdllkkllkkdpkkRltaeellqhpyl 217.0 1.9e-66 Protein kinase domain 527 Cluster-782.1791-1F PF07714.14 115 315 4 210 ERVVGQGSFGIVFQAKCL----ESGETVAIKKVLQDKRYK-----NRELQTIRLLDHPNVVSLKHCFFsttDKDElyLNLVLEYVPETVYRVTRHYSKANQRMPMIYVKLYTYQIFRALAYIHGIGVCHRDIKPQNLLVNpHTHQLKLCDFGSAKVLVK---GEPNISYICSRYYRAPELIFGATeYTTAIDVWSVGCVLAELLL-GQPLFPGE ++ +G+G+fG V+++++ ++ +va+K++ ++++ + +e+++++ l+hpn+v+l + ++++ l +v+eyv++ + + +++++++ + + +++qi ++++y++ + Hrd+ +N L++ ++++ k++DfG a+ + k + + + ++ + apE ++ + +t++ DvWs G +l E++ g+ +pg gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvct...keep..llivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLls.enkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekk.ftsksDvWsfGvllwEiftlgeepypgl 87.9 4.4e-27 Protein tyrosine kinase 527 Cluster-782.2132-0R RLK-Pelle_DLSV 80 135 2 57 NKIGEGGFGSVYKGELSDGTVIAVKQLSSRSRQGNREFLNEIGMISCLQHPNLVKL nk+GeGgfg+vYkg+l+dg+ +Avk+ls++s+qg++ef ne+ +i+ lqh nlvkL nklGeGgfgkvYkgkledgkevAvkrlskkskqgkeefknevvliaklqhrnlvkL 73.5 1.3e-22 RLK-Pelle_DLSV 135 Cluster-782.2132-0R PF00069.22 78 135 3 63 AANKIGEGGFGSVYKGE-LSDGTVIAVKQLSSRSRQGNRE--FLNEIGMISCLQHPNLVKL +k+GeG+fG+Vyk+ ++g +AvK+++ ++++ ++e +l+Ei ++ l+hpn+v+l kleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrl 37.2 1.3e-11 Protein kinase domain 135 Cluster-782.2132-0R PF07714.14 79 135 4 66 ANKIGEGGFGSVYKGELS-----DGTVIAVKQLSSRSRQG-NREFLNEIGMISCLQHPNLVKL +k+GeG fG+V++g+l+ + + +avK+l++++++ ++efl+e+ +++ l+hpn+vkl gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkl 34.3 9.4e-11 Protein tyrosine kinase 135 Cluster-782.2283-1F CAMK_CDPK 238 500 1 259 YEIGDEVGRGHFGYTCSARGKKgslKGQDVAVKVIPKAKMTTAIAIEDVRREVKILRALTGHKNLVQFYDAYEDEDNVYIVMALCKGGELLDRILARgGKYSEEDAKAVMVQILSVVAYCHLQGVVHRDLKPENFLFTSKDEHSPLKAIDFGLSDYVKPDERLNDIVGSAYYVAPEVLHRSYGTEADMWSIGVIAYILLCGSRPFWARTESGIFRAVLKADPSFDEAPWPTLSPEAVDFVKRLLNKDYRKRLTAAQALSHPWL ye+g+e+GrG+fG+++ a k+ +g++vAvK+i+k+k+++a ++edvrrevkil++l+ghkn+vq+++ayed+d+v++vm lc+ggelldrilar gkyse++a++v+ qil+vva+cH +gvvhrDlKPeNfl+tsk+e++plkaiDFGls++vk++erl+divGs+yyvaPEvl+rsyg+ead+Ws+Gvi+yillcg++pfwa+te++if+avlka+++f+++pw+++s+ea d+v+rlL+kd +kRlta+q+L+hpWl yelgkelGrGefGvvrlateka...tgeevAvKsiskrklskaedvedvrrevkilkhlsghknvvqlkgayedkdsvhlvmelceggelldrilar.gkyseraaakvvrqilevvaacHskgvvhrDlKPeNflltskeedaplkaiDFGlsvfvkegerledivGspyyvaPEvlkrsygkeadvWsaGvilyillcgvppfwaeteeeifkavlkaeldfksepwksvseeakdlvrrlLekdpkkRltaeqvLehpWl 397.6 2.1e-121 CAMK_CDPK 783 Cluster-782.2283-1F PF00069.22 238 500 1 264 YEIGDEVGRGHFGYTCSARGKKgslKGQDVAVKVIPKAKMTTAIAiEDVRREVKILRALTgHKNLVQFYDAYEDEDNVYIVMALCKGGElLDRILARGGKYSEEDAKAVMVQILSVVAYCHLQGVVHRDLKPENFLFTsKDEHspLKAIDFGLSDYVKPDERLNDIVGSAYYVAPEVL-HRSYGTEADMWSIGVIAYILLCGSRPFWARTESGIFRAVLKA---------DPSFDEAPWPTLSPEAVDFVKRLLNKDYRKRLTAAQALSHPWL ye ++G+G fG +a+ k+ +g+ vAvK+i k k++ ++v+rE+kil+ l h+n+v++y+++e++d++y+v+ +++gge l+++l r g++see+ak ++ qil+ ++y+H +g++HrDlKpeN+L++ ++++ lK +DFGl+ ++ +++l+++vg+ +Y+APEvl +++y++++D+Ws+Gvi y ll+g pf++++++ +++ l+ + +++ + + +ls+ea d++k+ll+kd +kRlta+++l+hp+l yekleklGeGsfGkVykaveke...tgkivAvKkikkekakkkke.kkvlrEikilkklk.hpnivrlyevfeekdelylvleyvegge.ladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLid.ekge..lKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 235.0 6.1e-72 Protein kinase domain 783 Cluster-782.2283-1F PF07714.14 240 492 3 254 IGDEVGRGHFGYTCSARGK-KGSLKGQDVAVKVIPKAKMTTAiaIEDVRREVKILRALtGHKNLVQFYDAYEDEDNVYIVMALCKGGELLDRILAR--GGKYSEEDAKAVMVQILSVVAYCHLQGVVHRDLKPENFLFTSkdeHSPLKAIDFGLSDYVKPDERL---NDIVGSAYYVAPEVLH-RSYGTEADMWSIGVIAYILLC-GSRPFWARTESGIFRAVlKADPSFDEApwPTLSPEAVDFVKRLLNKDYRKRLTAA +g+++G+G+fG ++++ k + + k ++vavK++ + ++ ++ e++ +e+ki+++l h+n+v+++ ++ +e++++iv+ +++gG+Ll+ + ++ k + +d +++qi + ++y + + +vHrdl N L ++ ++ k DfGL++ ++ d++ ++ + ++apE+l+ +++ +++D+Ws Gv+ + +++ g++p++ +++ +++++ k++ ++ + ++e +++k+ +++d ++R t + lgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateee..keefleeakimkkl.khpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlse...nkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevlekl.kegkrlekp..ekcpeelyelmkqCweedpeeRptfk 109.4 1.2e-33 Protein tyrosine kinase 783 Cluster-782.2371-0R CMGC_MAPK 1 111 124 230 YHRDLKPKNILANANCKLKICDFGLARVAfndTPTTIFWTDYVATRWYRAPELCGSfFSKYTPAIDIWSIGCIFAEVLTGKPLFPGKNVVHQLDLITDLLGTPSMDTISRV +hrDlkpkn+l+nancklkicDfGlar+a +++t ++t+yv+trwyraPel+ s +skYt+aiD+Ws+GCifae+lt+kplfpgk+vv+ql+lit+l+Gtps++++++v lhrDlkpknlllnancklkicDfGlarsa...ssetdllteyvvtrwyraPellls.sskYtsaiDvWsvGCifaelltrkplfpgkdvvdqlkliteliGtpseedlesv 180.7 2.8e-55 CMGC_MAPK 549 Cluster-782.2371-0R PF00069.22 2 102 121 222 HRDLKPKNILANANCKLKICDFGLARVAFNDTPttifWTDYVATRWYRAPELCGSffSKYTPAIDIWSIGCIFAEVLTGKPLFP---GKN----VVHQLDLITDLLGT HrDlKp+NiL + + +lKi+DFGla+ + ++++ t++v+tr+Y+APE+ ++ ++y++++D+Ws+G+i++e+ltgkp+f+ gk+ ++ql i+++lg+ HrDlKpeNiLidekgelKitDFGlakelesssk....ltsfvgtreYlAPEvlke..neyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilge 97.3 6e-30 Protein kinase domain 549 Cluster-782.2371-0R PF07714.14 2 87 127 210 HRDLKPKNILANANCKLKICDFGLARVAFNDTPTTIFWTDYVATRWYrAPELCgsFFSKYTPAIDIWSIGCIFAEVLT-GKPLFPGK Hrdl +N+L + n + ki+DfGLar +d ++ ++ + +W+ apE + +k+t + D+Ws G + E++t g+ +pg HrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWm.apEsl..kekkftsksDvWsfGvllwEiftlgeepypgl 46.2 2.2e-14 Protein tyrosine kinase 549 Cluster-782.2376-0R CAMK_CAMKL-CHK1 119 374 1 256 YEVGRTIGEGTFAKVKFARNSETGQPVALKILDKDKVLKHKIAEQIKREVATMKLIKHPNVVRLYEVMASKTKIFIVLEFVTGGELFDKIVNHGRMQEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDAAGNLKVSDFGLSALSQQVKDDGLLHTTCGTPNYVAPEVLNDRGYDGATADLWSCGVILFVLLAGYLPFDDSNLMNLYNKISSAEFTCPPWISFNARKLITRILNPNPVTRITIPEILEDPWF ye+Gr++Gegtfakvk+ar+ etg+ va+k+ldk+kvlk+k++eqikre++++kl++hpnvvrl+ev+a+k+ki++vle+v+GGelf+ki+++gr++edearkyfqqli+avdychsrgvyhrdlkpenllld++gnlkvsdfGlsal++q+++dgllhttcGtP+yvaPevl+++gydga+ad+WscGvilfvllagylPf+d+nl++ly+ki++aef++p+w+s +a+kli+r+l+pnp triti eile++Wf yelGrllGegtfakvklardletgesvaikvldkekvlkaklveqikreisvlklvrhpnvvrllevlatkskiylvleyvkGGelfekiakkgrlkedearkyfqqlisavdychsrgvyhrdlkpenllldekgnlkvsdfGlsalaeqlredgllhttcGtPayvaPevlkkkgydgakadvWscGvilfvllagylPfedenlvelyrkilkaefklpkwlskeakklisrlldpnpetritieeileeeWf 455.5 3.6e-139 CAMK_CAMKL-CHK1 618 Cluster-782.2376-0R PF00069.22 119 374 1 264 YEVGRTIGEGTFAKVKFARNSETGQPVALKILDKDKVLKHKIaEQIKREVATMKLIKHPNVVRLYEVMASKTKIFIVLEFVTGGELFDKIVNHGRMQEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDAAGNLKVSDFGLSALSQQVKDdglLHTTCGTPNYVAPEVLNDRGYdGATADLWSCGVILFVLLAGYLPFDDSNLMNLYN----------KI---SSAEFTCPPWISFNARKLITRILNPNPVTRITIPEILEDPWF ye+ +++GeG+f+kV a+++etg+ vA+K+++k+k k k +++ rE++ +k +khpn+vrlyev+ +k+++++vle+v ggel+d + ++g ++e+ea+k+++q++++++y+Hs+g+ HrDlKpeN+L+d g+lK++DFGl++ ++ ++ l++ +gt++Y+APEvl++++y ++++D+Ws+Gvil+ ll+g pf +++ + ++ ki ++ ++ + +s +a++l++++l+ +p +R+t+ e+l++p++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeney.skkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 247.0 1.3e-75 Protein kinase domain 618 Cluster-782.2376-0R PF07714.14 121 370 3 258 VGRTIGEGTFAKVKFARNS----ETGQPVALKILDKDKVLKHkiAEQIKREVATMKLIKHPNVVRLYEVMASKTKIFIVLEFVTGGELFDKIVNH---GRMQEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDAAGNLKVSDFGLSALSQQVKDDGLLHTTCGTPNYVAPEVLNDRGYDgATADLWSCGVILFVLLA-GYLPFDDSNLMNLYNKISSA-EFTCPPWISFNARKLITRILNPNPVTRITIPEILE +g+++GeG+f++V ++ + ++ + va+K+l++++ ++ e++ +e+++mk +khpn+v+l+ v+ ++ +++iv+e+v+gG+L + + ++ +++ ++ ++ +q+ ++++y +s+ + Hrdl N Ll+ k+sDfGL+ ++ ++ +++ +++apE+l+++ + +D Ws Gv+l+ ++ g p+ + + +++++k+++ + ++p ++ + +l+++ ++ +p R t+ e++e lgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateee..keefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkft.sksDvWsfGvllwEiftlgeepypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelve 129.1 1.2e-39 Protein tyrosine kinase 618 Cluster-782.2380-1R RLK-Pelle_CrRLK1L-1 1 195 69 263 YDYMAQGTLREHLYKTQKPPLPWKQRLEICIGAARGLHYLHTGAKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSLDHTHVSTVVKGSFGYLDPEYFRRQQLTEKSDVYSYGVVLFEILCARPALNPTLPKEQVSLAEWALHCYNKGILDQIMDPYLKGKIAPECFKKFADTAVKCLSDVGTERPSMGDVL y+yma+Gtlrehly+++kppl WkqrleiciGaarGlhylhtgak+tiihrdvkttnillde++vakv+dfGlsktgp+ld+thvst+vkgsfgyldPeyfrrqqlteksdvys+Gvvl+e+lcarpa+np+lpkeqv+laewal++ +kg ld+i+d+ lkgkiape++kkfa+ta kcl+d g++rpsmgdvl yeymakGtlrehlygsdkpplsWkqrleiciGaarGlhylhtgakktiihrdvkttnilldenfvakvadfGlsktgpeldqthvstavkgsfgyldPeyfrrqqlteksdvysfGvvllevlcarpainpalpkeqvnlaewalklkkkgkldeivdeklkgkiapeslkkfaetaekcladegvdrpsmgdvl 359.0 1.1e-109 RLK-Pelle_CrRLK1L-1 634 Cluster-782.2380-1R PF07714.14 2 195 81 257 DYMAQGTLREHLYKT-QKPPLPWKQRLEICIGAARGLHYLHtgaKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSLDHTHVSTVVKGSFGYLDPEYFRRQQLTEKSDVYSYGVVLFEILC--ARPalnptlpkeqvslaewALHCYNKGILDQIMDPYlKGKIAPECFKKFADTAVKCLSDVGTERPSMGDVL +y+++G+L+++L k+ +k++l k+ l++++ A+G++yL+ +++++Hrd+ + N+Ll+e+ v+k+sDfGL+++ + d++++++ k ++ ++ pE ++++++t+ksDv+s+Gv+l+Ei++ ++p ++ n+ +l+++ + + + + +c +++++ +C++ +eRp++ +++ eyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLe...skklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep................ypglsneevleklkegk.rlekpekcpeelyelmkqCweedpeeRptfkelv 104.2 4.6e-32 Protein tyrosine kinase 634 Cluster-782.2380-1R PF00069.22 2 194 78 258 DYMAQGTLREHLYktQKPPLPWKQRLEICIGAARGLHYLHtgaKHTIIHRDVKTTNILLDEKWVAKVSDFGLSKTGPSLDHthvSTVVKGSFGYLDPEYFRRQQLTEKSDVYSYGVVLFEILCARPALNPTLPKEQVSLAEWALHCYNKgILDqimDPYLKGKIAPECFKKFADTAVKCLSDVGTERPSMGDV +y+ +g+l ++l +k l+ ++ +i+ ++gl+ylH ++ iiHrD+K+ NiL+dek + K++DFGl+k s + t + g+ Yl PE ++++ ++k+Dv+s+Gv+l+e+l+ +p ++ + ke+v+ l+ k il+ + +k + a e+ +++ d k+l+ ++R+++ ++ eyveggeladlls..rkgslseeeakkiakqilegleylH...skgiiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilk.ilg...etkeklpeaselseeakdllkkllkkdpkkRltaeel 90.4 7.8e-28 Protein kinase domain 634 Cluster-782.2382-0F RLK-Pelle_DLSV 1 172 94 266 WPTRFKICVGIARGLAFLHDESIIKIVHRDIKATNVLLDRDLNPKISDFGLARLNEGEKTHIST-KVAGTIGYMAPEYALWGYLTDKADVYSFGVVALEIVSGKSNNNYMPSHNFICLLDWASHLQESKNVDELVDPKLGSRVNREEVGRMVKVALLCTNVTPSVRPTMSEVV W+trfki+ giarGl++Lh+es +ki+hrD+Ka+N+LLd+++npki+DFGlarl e ++t++st +v+gt+gYmaPeyal g l+ k+DvysfGv+ leivsGk+n++ + +++++ ll++a +l+e++++ elvd++l +++++eev r++++allc++ +p+ rptmsevv WktrfkiikgiarGllYLheesrlkiihrDlKasNiLLdkemnpkiaDFGlarlfeedqteastkrvvgtlgYmaPeyalegqlseksDvysfGvlvleivsGkknsslkeeeeaeelleeawklweeekllelvdkslkeeaekeevlrcieiallcvqekpekrptmsevv 224.0 1.6e-68 RLK-Pelle_DLSV 273 Cluster-782.2382-0F PF07714.14 4 175 106 260 RFKICVGIARGLAFLHDESiikIVHRDIKATNVLLDRDLNPKISDFGLARLN-EGEKTHISTKVAGTIGYMAPEYALWGYLTDKADVYSFGVVALEIVS-GKSNnnympshnficlldwASHLqESKNVDELVDPKLGSRVNREEVGRMVKVALLCTNVTPSVRPTMSEVVQML +++++ iA+G+++L++++ +vHrd+ a NvLl+++ kisDfGLar + ++++ +++ + +mapE + +t k+Dv+sfGv+ Ei++ g++ ++l ++++v e ++ + + +++ ++ ++ C + +p+ Rpt++e+v+ l llsfalqiAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep...............ypgl.sneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 92.8 1.3e-28 Protein tyrosine kinase 273 Cluster-782.2382-0F PF00069.22 6 173 102 260 KICVGIARGLAFLHDESiikIVHRDIKATNVLLDRDLNPKISDFGLARLNEGEKThiSTKVAGTIGYMAPEYALWGYLTDKADVYSFGVVALEIVSGKSNNNYMPS-HNFICLLDWashLQESKNVDElvDPKLGSRVNREEVGRMVKVALLCTNVTPSVRPTMSEVVQ ki+ i++gl++lH+++ i+HrD+K N+L+d++ + Ki+DFGla+ e +++ t++ gt Y+APE + k+Dv+s Gv+ +e+++gk + + +++ ld l+++ ++ + + k+ +++++e + ++ + +++p+ R+t++e++q kiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldq...lekilkilg..etkeklpeaselseeakdllkkllkkdpkkRltaeellq 89.0 2.1e-27 Protein kinase domain 273 Cluster-782.2384-0R RLK-Pelle_LRR-VI-1 23 275 1 264 LIGEGTHGQVYKGWLTDGTLVAIRSLKMRKRHSIQSYTHQIELISKLRHSHLVSSIGHCFECHRD-DSTVSRMFLIFEYVPNGTLRKFISEGNCGQKFTWTQRITAATEVARGIQFLHTGMVPGVHSNHLKIKDVLLDHDLHAKISNYNIPLLMSLHGSKEK-----------HGLMPEKNDIYDFGVILLEMIVGRMIVSENDVCISKDILLVSLSADEKgRRSIVDPTVHKECSDNSLRTLIELCVRCLSNEPSERPSVEDVI l+Geg++G++ykG l +gtlvair+lk++k++s+qs+++q+el+skLrH hLvs +Ghc+e++ d ds+vsr+fl++eyv+nG+lr+++se++ +++++W+qR+++a++va+giqfLHtg+vPg+ +n+Lki+++lLd+ l ak+s+y++p+l+ ++e+ + +k+D+ydfGviLle+ivG+ + s++++ + k+ l ls++++ rr++vdptv+k csd+sl+t+ie++++Cl++e+s+rPs+edv+ llGegslGklykGklengtlvairclklkkkessqslkqqlellskLrHrhLvsvlGhcieseldedsavsrlflvseyvsnGslrshlsesskkkvlkWsqRlsvaigvakgiqfLHtgvvPgifennLkienilLdetlvaklsdyglpilseelkkeeaagegkkgaeseskeerdkeDvydfGviLleiivGkpvtskkelevlkeelesllseege.rrelvdptvsktcsdeslstvieialkClakeassrPsiedvL 326.2 9.9e-100 RLK-Pelle_LRR-VI-1 352 Cluster-782.2384-0R PF07714.14 22 276 5 258 NLIGEGTHGQVYKGWLT-----DGTLVAIRSLKMRKRHS-IQSYTHQIELISKLRHSHLVSSIGHCFechrD--DstvsrMFLIFEYVPNGTLRKFISEGNCGQKFTWTQRITAATEVARGIQFLHTGMVpgVHSNhLKIKDVLLDHDLHAKISNYNIPLLM---SLHGSKE--------------KHGLMPEKNDIYDFGVILLEMIV-GRMIvsendvciskdillV-SLsADEKGRRSIvDPTVHKECSDNSLRTLIELCVRCLSNEPSERPSVEDVIW + +GeG+ G+V++g l+ + + va+++lk +++++ ++ ++++++++kl+h ++v+ +g c + +++++eyv++G+L+kf+ + + +k+t ++ + a+++A+G+++L+ + vH + l ++vLl+++ ++kis + + + + +ke k++ + +k D++ fGv+l E++ g++ + +l +e+ + + + + e+ ++ ++l el +C++++p+eRp+ ++++ kklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvct....keep.....llivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskkl..vHrd.laarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep..............ypgl.sneevlekl.kegkrlekpekcpeelyelmkqCweedpeeRptfkelve 79.0 2.3e-24 Protein tyrosine kinase 352 Cluster-782.2384-0R PF00069.22 19 274 2 258 NESNLIGEGTHGQVYKGW-LTDGTLVAIRSLKMRKRHSIQS--YTHQIELISKLRHSHLVSSIGHCFEchrddstVSRMFLIFEYVPNGTLRKFISegnCGQKFTWTQRITAATEVARGIQFLHTGMVpgVHsNHLKIKDVLLDHDLHAKISNYNIPLLMSLHGS-KE-------------KHGLMPEKNDIYDFGVILLEMIVGRMIVSEND--VCISKDILLVSLSADE-KgrrsivDPTVHKECSDNSLRTLIELCVRCLSNEPSERPSVEDV ++ + +GeG+ G+Vyk+ ++g vA+ +k +k+ + + +++ i+++ kl+h+++v ++ + e ++++l++eyv++g+l +++s ++++ ++ a+++++g+++lH + +H lK + +L+d++ + Ki+ + + ++ + + ++ k+ + +k D++ Gvil+e++ g+++ s+++ ++k++ + +++ + + +++ + ++ +++++l+ ++l+ +p++R+++e++ ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee.......kdelylvleyveggeladlls...rkgslseeeakkiakqilegleylHskgi..iH.rDlKpeNiLidekgelKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg......etkeklpeaselseeakdllkkllkkdpkkRltaeel 70.1 1.2e-21 Protein kinase domain 352 Cluster-782.248-1F AGC_NDR 102 353 1 209 FEPLTMIGKGAFGEVRICREKSTAHVYAMKKLKKSEMLRRGQVEHVKAERNLLAEVDSNCIVKLYCSFQDEEYLYLIMEYLPGGDMMTLLMRKDILTEEEARFYVGETVLAIESIHKHNYIHRDIKPDNLLLDRNGHMKLSDFGLCKPLDCSniqekdfsvgnsysgalqsdgrpappkrtqqeqlqhwqrnrrmLAYSTVGTPDYIAPEVLLKKGYGMECDWWSLGAIMYEMLVGYPPFYSDEPMSTCRKI fe lt+ig+gafgevr+crek+t++vyamkklkksemlrrgqvehvkaernllaevds++ivkly+sfqdeeylylimeylpggd+mtllmrkd+lte+earfyv+e+vlaiesihkhnyihrdikpdnllld++gh+klsdfglckpld++ laystvgtpdyiapevllkkgygmecdwwslgai+yemlvgyppfysd+p++tcrki felltiigrgafgevrlcrekatgevyamkklkksemlrrgqvehvkaernllaevdselivklyysfqdeeylylimeylpggdlmtllmrkdtltedearfyvaesvlaiesihkhnyihrdikpdnllldkeghlklsdfglckpldak...........................................laystvgtpdyiapevllkkgygmecdwwslgailyemlvgyppfysddplttcrki 456.5 1.6e-139 AGC_NDR 353 Cluster-782.248-1F PF00069.22 104 347 3 203 PLTMIGKGAFGEVRICREKSTAHVYAMKKLKKSEMLRRGQvEHVKAERNLLAEVDSNCIVKLYCSFQDEEYLYLIMEYLPGGDMMTLLMRKDILTEEEARFYVGETVLAIESIHKHNYIHRDIKPDNLLLDRNGHMKLSDFGLCKPLDCSNIqekdfsvgnsysgalqsdgrpappkrtqqeqlqhwqrnrrmlAYSTVGTPDYIAPEVLLKKGYGMECDWWSLGAIMYEMLVGYPPFYSDEPM l+ +G+G+fG+V ++ek+t + +A+Kk+kk+++ + + ++v +E ++l++++++ iv+ly +f+++++lyl++ey++gg++++ll rk +l+eeea++++ +++ ++e +H+++ iHrD+Kp+N+L+d++g++K++DFGl+k l+ s+ + s vgt++Y+APEvl +++y+ ++D+WslG i+ye+l g ppf++++ kleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk..........................................ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgk 193.7 2.4e-59 Protein kinase domain 353 Cluster-782.248-1F PF07714.14 106 250 5 154 TMIGKGAFGEVRICREK----STAHVYAMKKLKKSEMLRRgqVEHVKAERNLLAEVDSNCIVKLYCSFQDEEYLYLIMEYLPGGDMMTLLMRK---DILTEEEARFYVGETVLAIESIHKHNYIHRDIKPDNLLLDRNGHMKLSDFGLCKPL + +G+GafGeV ++ k ++ a+K+lk++ + ++ e++ e +++ +++ + ivkl+ +ee l++++ey++gGd+ + L +k + lt ++ ++ + ++e +++++++Hrd+ N Ll++n ++k+sDfGL++ + kklGeGafGeVvegtlkgekekkevkvavKtlkeeateee..keefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardi 80.5 7.9e-25 Protein tyrosine kinase 353 Cluster-782.2507-0F RLK-Pelle_LRR-II 367 500 90 224 AKPPLDWGTRKRIALGAARGLLYLHEQCDPKIIHRDVKAANILLDDYCEAVVGDFGLAKLLDHHDSHITTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGQRALEFGKGANQKGAML-DWVSTTRNQ +kp+ldw trkrialGaarGl ylheqcdpkiihrdvkaanilld+++eavvgdfglaklld++dsh+ttavrGtvGhiapeylstG+ssektdvfG+GilllelitGqrale+++ a++++++l dwv + +++ gkpaldwetrkrialGaarGlsylheqcdpkiihrdvkaanilldeefeavvgdfglaklldkkdshvttavrGtvGhiapeylstGkssektdvfGyGilllelitGqralelsrlaededvllldwvkklkke 241.9 5.4e-74 RLK-Pelle_LRR-II 2322 Cluster-782.2507-0F PF00069.22 198 295 2 101 SSKNILGKGGFGIVYKGC-LQDGTVVAVKRLKDGNAIGGE-IQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGKKIFQVTQVT + ++ lG+G+fG Vyk++ ++g vAvK++k +a + ++++E++++ h+n++rly+++ ++ e++lv ++++g++a++l+ k++++ +++ ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeak 44.7 6.8e-14 Protein kinase domain 2322 Cluster-782.2507-0F PF00069.22 375 491 99 210 TRKRIALGAARGLLYLHEQCdpkIIHRDVKAANILLDDYCEAVVGDFGLAKLLDHHDShiTTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGQRALEFGKGANQKGAML + k+ia ++gl ylH+++ iiHrD+K +NiL+d+ e ++DFGlak l+++ + +t + gt +APE l++ + s+k+Dv++ G++l+el+tg+ ++ kg +++ ++l eakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekel 79.4 1.9e-24 Protein kinase domain 2322 Cluster-782.2507-0F PF07714.14 200 476 4 205 KNILGKGGFGIVYKGCLQ-----DGTVVAVKRLKDGNAIGGEIQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGKkifqvtqvtrtpystnc*kanfcsiklkhninhts*ialhshphi*wfllvltlriqilae*kftcpqakyfhvcclyiLAKPPLDWGTRKRIALGAARGLLYLHEQcdpKIIHRDVKAANILLDDYCEAVVGDFGLAKLL-DHHDSHITTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELIT-GQR ++ lG+G fG V++g l+ + + vavK lk+++ + +f +e+++++ h+n+++l+g+c+ + l+v ++++G++ + L+ k +k++l+ + ++al A+G+ yL+++ k++Hrd+ a N+Ll++ + ++DfGLa+ + ++++ + ++ + v +apE l++++ ++k+Dv+ fG+ll E++t g++ gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk...............................................................................eekekltlkdllsfalqiAkGmeyLesk...klvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgee 117.1 5.1e-36 Protein tyrosine kinase 2322 Cluster-782.2583-0F RLK-Pelle_LRR-II 200 287 1 88 KNILGKGGFGIVYKGCLQDGTVVAVKRLKDGNAIGGEIQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGKK knilGkGgfg vykG+l+dgt+vavkrlk+ ++ gge+qfqteve+islavhrnllrl+Gfc+t+ erllvyp+m+ngsvasrl+ +k knilGkGgfgkvykGrladgtlvavkrlkeeesaggelqfqtevelislavhrnllrliGfcttsterllvypymengsvasrlrelk 146.2 8.3e-45 RLK-Pelle_LRR-II 1667 Cluster-782.2583-0F PF00069.22 198 296 2 102 SSKNILGKGGFGIVYKGC-LQDGTVVAVKRLKDGNAIGGE-IQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGKKIFQVTQVTR + ++ lG+G+fG Vyk++ ++g vAvK++k +a + ++++E++++ h+n++rly+++ ++ e++lv ++++g++a++l+ k++++ +++ + ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakk 45.7 3.5e-14 Protein kinase domain 1667 Cluster-782.2583-0F PF07714.14 200 286 4 95 KNILGKGGFGIVYKGCLQ-----DGTVVAVKRLKDGNAIGGEIQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGK ++ lG+G fG V++g l+ + + vavK lk+++ + +f +e+++++ h+n+++l+g+c+ + l+v ++++G++ + L+ k gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk 43.0 2.2e-13 Protein tyrosine kinase 1667 Cluster-782.2583-2F RLK-Pelle_LRR-II 315 448 90 224 AKPPLDWGTRKRIALGAARGLLYLHEQCDPKIIHRDVKAANILLDDYCEAVVGDFGLAKLLDHHDSHITTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGQRALEFGKGANQKGAML-DWVSTTRNQ +kp+ldw trkrialGaarGl ylheqcdpkiihrdvkaanilld+++eavvgdfglaklld++dsh+ttavrGtvGhiapeylstG+ssektdvfG+GilllelitGqrale+++ a++++++l dwv + +++ gkpaldwetrkrialGaarGlsylheqcdpkiihrdvkaanilldeefeavvgdfglaklldkkdshvttavrGtvGhiapeylstGkssektdvfGyGilllelitGqralelsrlaededvllldwvkklkke 242.5 3.6e-74 RLK-Pelle_LRR-II 1666 Cluster-782.2583-2F PF00069.22 323 439 99 210 TRKRIALGAARGLLYLHEQCdpkIIHRDVKAANILLDDYCEAVVGDFGLAKLLDHHDShiTTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGQRALEFGKGANQKGAML + k+ia ++gl ylH+++ iiHrD+K +NiL+d+ e ++DFGlak l+++ + +t + gt +APE l++ + s+k+Dv++ G++l+el+tg+ ++ kg +++ ++l eakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekel 80.1 1.1e-24 Protein kinase domain 1666 Cluster-782.2583-2F PF07714.14 318 424 100 205 PLDWGTRKRIALGAARGLLYLHEQcdpKIIHRDVKAANILLDDYCEAVVGDFGLAKLL-DHHDSHITTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELIT-GQR +l+ + ++al A+G+ yL+++ k++Hrd+ a N+Ll++ + ++DfGLa+ + ++++ + ++ + v +apE l++++ ++k+Dv+ fG+ll E++t g++ kltlkdllsfalqiAkGmeyLesk...klvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgee 66.6 1.4e-20 Protein tyrosine kinase 1666 Cluster-782.2687-2F CAMK_CAMKL-CHK1 127 381 1 256 YELGRLLGHGTFAKVYHARNLQTGKSVAMKVVGKEKVIRVGMTEQVKREISVMKMMKHPNIVELHEVMASKSKIYFALELVRGGELFAKIAK-GRLREDAARSYFQQLISAIDFCHSRGVYHRDLKPENLLLDEEGNLKVTDFGLTAFSDHLRQDGLLHTTCGTPAYVAPEVIGKKGYDGAKADIWSCGVILYVLLAGYLPFQEDNIMAMYKKIYRGDFKCAPWFSSEARRLITKMLDPNPNTRISISKIMDSSWF yelGrllG+gtfakv++ar+l+tg+sva+kv+ kekv++ +++eq+kreisv+k+++hpn+v+l+ev+a+kskiy+ le+v+GGelf+kiak grl+ed+ar yfqqlisa+d+chsrgvyhrdlkpenlllde+gnlkv+dfGl+a++++lr+dgllhttcGtPayvaPev+ kkgydgakad+WscGvil+vllagylPf+++n++++y+ki++++fk+ +w+s+ea++li+++ldpnp+tri+i++i++++Wf yelGrllGegtfakvklardletgesvaikvldkekvlkaklveqikreisvlklvrhpnvvrllevlatkskiylvleyvkGGelfekiakkgrlkedearkyfqqlisavdychsrgvyhrdlkpenllldekgnlkvsdfGlsalaeqlredgllhttcGtPayvaPevlkkkgydgakadvWscGvilfvllagylPfedenlvelyrkilkaefklpkwlskeakklisrlldpnpetritieeileeeWf 448.7 4.4e-137 CAMK_CAMKL-CHK1 659 Cluster-782.2687-2F PF00069.22 127 381 1 264 YELGRLLGHGTFAKVYHARNLQTGKSVAMKVVGKEKVIRVGMtEQVKREISVMKMMKHPNIVELHEVMASKSKIYFALELVRGGELFAKIA-KGRLREDAARSYFQQLISAIDFCHSRGVYHRDLKPENLLLDEEGNLKVTDFGLTAFSDHLRQdglLHTTCGTPAYVAPEVIGKKGYdGAKADIWSCGVILYVLLAGYLPFQEDNIMAMYKKIYRG-------------DFKCAPWFSSEARRLITKMLDPNPNTRISISKIMDSSWF ye + lG G+f+kVy a++ +tgk vA+K++ kek ++v rEi+++k +khpniv+l ev+ +k+++y+ le+v+ggel+ + kg l e+ a+++++q++++++++Hs+g+ HrDlKpeN+L+de+g+lK+tDFGl + ++ + l++ +gt+ Y+APEv+++++y ++k+D+Ws+Gvily ll+g pf++++ ++k+++ +++ a +s+ea++l++k+l+ +p++R++++++++++++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeney.skkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 247.5 9.3e-76 Protein kinase domain 659 Cluster-782.2687-2F PF07714.14 128 376 2 257 ELGRLLGHGTFAKVYHARNL----QTGKSVAMKVVgKEKViRVGMTEQVKREISVMKMMKHPNIVELHEVMASKSKIYFALELVRGGELFAKIAKG----RLREDAARSYFQQLISAIDFCHSRGVYHRDLKPENLLLDEEGNLKVTDFGLTAFSDHLRQDGLLHTTCGTPAYVAPEVIGKKGYDgAKADIWSCGVILYVLLA-GYLPFQEDNIMAMYKKIYRGDFKCAPW-FSSEARRLITKMLDPNPNTRISISKIM elg+ lG+G+f++V++++ ++ +va+K++ ke+ + +e++ +e+++mk +khpniv+l+ v+ +++++++ +e+v+gG+L + k +l+ + s+ +q+ +++++ +s+ + Hrdl N Ll+e+ k++DfGL+ + + +++ ++apE++ +k + k+D+Ws Gv+l+ ++ g p+++ + + +++k+ +g +p ++e +l+++ ++ +p+ R ++++++ elgkklGeGafGeVvegtlkgekekkevkvavKtl.keea.teeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkft.sksDvWsfGvllwEiftlgeepypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelv 121.0 3.5e-37 Protein tyrosine kinase 659 Cluster-782.2711-2F CK1_CK1-Pl 238 497 1 260 YKTERKLGKGGFGQVYVGRRVSGGSERAGPDAIEVALKFEHRNSKGCNYGPPYEWQVYNTLNGCYGIPWVHYKGRQGDFYILVMDMLGPSLWDVWNSLGQSMSPNMVACIAVEAISILEKLHMKGFVHGDVKPENFLLGQPGTPDEKKLYLIDLGLASRWKDPSSGQHVEYDQRPDIFRGTIRYASVHAHLGRTGSRRDDLESLAYTLIFLIKGRLPWQGYQGDNKSFLVCKKKMATSPELMCCFCPPPFKLFLEAVTNM yk+erklgkggfgqvyvgrrvs++++r+g+da+evalkfehr+skgcnygppyewqvyntl+g+yg+p vhykgrqgd+yilvmd+lgpslwdvwns gq++s +mvaciaveaisileklh+kg+vhgdvkpenfllgqpgt++ekkl+l+dlglas+wkd +sgqhveydqrpd+frgt+ryasvhahlgrtgsrrddleslaytlifl++grlpwqgyqgdnk+flvckkkmatspe +c+++p++f+ f+e+v+n+ ykverklgkggfgqvyvgrrvssakdrtgadalevalkfehrsskgcnygppyewqvyntlggvygvpkvhykgrqgdyyilvmdllgpslwdvwnssgqalseemvaciaveaisileklhakgyvhgdvkpenfllgqpgtaeekklflvdlglaskwkdaasgqhveydqrpdvfrgtvryasvhahlgrtgsrrddleslaytlifllrgrlpwqgyqgdnkgflvckkkmatspeslcalapqafrefvevvvnl 543.3 6.2e-166 CK1_CK1-Pl 866 Cluster-782.2711-2F PF00069.22 238 470 1 212 YKTERKLGKGGFGQVYVGRRVSGGSeragpdaiEVALKFEHRNSKGCN--YGPPYEWQVYNTLNGCYGIPWVHYKGRQGDFYiLVMDMLG-PSLWDVWNsLGQSMSPNMVACIAVEAISILEKLHMKGFVHGDVKPENFLLGQPGTpdekkLYLIDLGLASRWKDPSSgqhveydqrPDIFRGTIRYASVHAHLGRTGSRRDDLESLAYTLIFLIKGRLPWQGYQGDNKSFLVCKK y++++klG+G+fG+Vy +++ + g +vA+K ++++ + E ++ ++l+ + + +++ ++ ++y lv++++ +l+d+ + +s+s++ + ia + ++ le lH kg++H D+KpeN+L+ + g l ++D+Gla++++ s+ + f gt +Y + ++ s+ D+ sl+ +l+ l+ g+ p++g +g++k +++ yekleklGeGsfGkVykaveketgk........ivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdely.lvleyveggeladlls.rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekge.....lKitDFGlakelesssk.........ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldq 59.1 2.7e-18 Protein kinase domain 866 Cluster-782.2711-2F PF07714.14 239 402 2 159 KTERKLGKGGFGQVYVGRRVSggseRAGPDAIEVALKFEHRNSKGC-NYGPPYEWQVYNTLNGCYGIPWVHYKGRQGDFYILVMDMLGPSLWDVWNSL--GQSMSPNMVACIAVEAISILEKLHMKGFVHGDVKPENFLLGQpgtpdEKKLYLIDLGLASRWKDPSS ++++klG+G fG+V+ g+ + + + ++va+K +++++ + e ++ ++l+ + + +++ +i++ + g +L + ++ ++++ + + ++a++ + +e L+ k +vH d+ N Ll + +k+ + D GLa++ ++ ++ elgkklGeGafGeVvegtlkg....ekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlse.....nkvvkisDfGLardiekdde 21.3 9.2e-07 Protein tyrosine kinase 866 Cluster-782.2742-2R STE_STE11 38 91 92 143 GAKPTHKLKLMMREIVIGLCYLHKKSMRYDNLKPENIFIEKDGEgkIRFHDYGF g+ + ++++ + r+i+ GL ylH+k++ + ++k++Ni+++++ge ++ D+G gklseslvrkytrqileGLeylHskgivHrDikgaNilvdsnge..vklaDFGl 26.7 3e-08 STE_STE11 617 Cluster-782.2742-2R PF00069.22 18 91 70 144 EKNLNMDVEVFEEMKYFVLLG---AKPTHKLKLMMREIVIGLCYLHKKSMRYDNLKPENIFIEKDGEgkIRFHDYGF +++l + +e+ e+ +++ ll + + +++k ++++i+ gl ylH+k++ + lKpeNi+i+++ge ++ D+G+ kdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekge..lKitDFGl 36.0 3.1e-11 Protein kinase domain 617 Cluster-782.2757-2R CAMK_CAMKL-CHK1 73 327 1 256 YEIGKLLGHGTFAKVYHARNVKTGENVAIKVIDKEKILKIGLIGHIKREISILRRVRHPNIVQLFEVMATKSKIFFVMEYVKGGELFNKVAK-GRLKEEVARKYFQQLISAVAFCHARGVYHRDLKPENILLDEDGNLKVSDFGLSAISEQIKQDGLFHTFCGTPAYVAPEVLARKGYDAAKVDIWSCGVILFVLMAGHLPFHDQNIMAMYKKIYKGDFRCPRWFTPELIRFLSRLLDTNPENRITIPEIMNNKWF ye+G+llG+gtfakv++ar+++tge+vaikv+dkek+lk +l+ +ikreis+l++vrhpn+v+l+ev+atkski++v+eyvkGGelf+k+ak grlke+ arkyfqqlisav++ch+rgvyhrdlkpen+llde+gnlkvsdfGlsa++eq+++dgl+ht cGtPayvaPevl++kgyd+ak+d+WscGvilfvl+ag+lPf+d+n++++y+ki+k++f++p+w+++e+ +++srlld+npe+riti ei++++Wf yelGrllGegtfakvklardletgesvaikvldkekvlkaklveqikreisvlklvrhpnvvrllevlatkskiylvleyvkGGelfekiakkgrlkedearkyfqqlisavdychsrgvyhrdlkpenllldekgnlkvsdfGlsalaeqlredgllhttcGtPayvaPevlkkkgydgakadvWscGvilfvllagylPfedenlvelyrkilkaefklpkwlskeakklisrlldpnpetritieeileeeWf 448.8 4.1e-137 CAMK_CAMKL-CHK1 412 Cluster-782.2757-2R PF00069.22 73 327 1 264 YEIGKLLGHGTFAKVYHARNVKTGENVAIKVIDKEKILKIGLiGHIKREISILRRVRHPNIVQLFEVMATKSKIFFVMEYVKGGELFNKVA-KGRLKEEVARKYFQQLISAVAFCHARGVYHRDLKPENILLDEDGNLKVSDFGLSAISEQIKQdglFHTFCGTPAYVAPEVLARKGYdAAKVDIWSCGVILFVLMAGHLPFHDQNIMA----MYKK------I---YKGDFRCPRWFTPELIRFLSRLLDTNPENRITIPEIMNNKWF ye + lG G+f+kVy a++ +tg+ vA+K+i+kek+ k ++ rEi+il++++hpniv+l+ev+ +k+++++v+eyv+ggel++ + kg l+ee a+k+++q++++++++H++g+ HrDlKpeNiL+de+g+lK++DFGl++ e+ ++ +++f+gt+ Y+APEvl +++y +kvD+Ws+Gvil+ l++g+ pf++++ ++++ i +k +++ ++ + +e++++l++ll+ +p++R+t+ e+++++++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeney.skkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 257.5 8.4e-79 Protein kinase domain 412 Cluster-782.2757-2R PF07714.14 74 323 2 258 EIGKLLGHGTFAKVYHARNV----KTGENVAIKVIDKEKILKIglIGHIKREISILRRVRHPNIVQLFEVMATKSKIFFVMEYVKGGELFNKVAKG----RLKEEVARKYFQQLISAVAFCHARGVYHRDLKPENILLDEDGNLKVSDFGLSAISEQIKQDGLFHTFCGTPAYVAPEVLARKGYDaAKVDIWSCGVILFVLMA-GHLPFHDQNIMAMYKKIYKGD-FRCPRWFTPELIRFLSRLLDTNPENRITIPEIMN e+gk lG+G+f++V++++ k+ +va+K++++e+ + ++ +e++i+++++hpniv+l v+ ++++++v+eyv+gG+L + + k +l+ + ++ +q+ +++++ +++ + Hrdl N+Ll+e+ k+sDfGL+ e+ ++ ++ ++apE+l +k + k D+Ws Gv+l+ ++ g+ p+++ + + +++k+ +g ++p+ ++el +++++ ++++pe+R t+ e+++ elgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateee..keefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkft.sksDvWsfGvllwEiftlgeepypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelve 134.5 2.6e-41 Protein tyrosine kinase 412 Cluster-782.2778-1F CMGC_GSK 141 423 1 283 AERIVGHGSFGVVFQAKCLETGETVAIKKVLQDKRYKNRELQTMRLLDHPNVVSLKHCFFSTTEKDELYLNLVLEYVPETLHRVVKHYNKLNQRTPLIYVKLYSYQIFRALSYIHRGIGVCHRDIKPQNLLVNPHTHQVKLCDFGSAKVLVKGEPNIYYICSRYYRAPELIFGATEYTTAIDIWSAGCVLAELLLGQPLFPGESGVDQLVEIIKVLGTPTREEIKCMNPNYTEYKFPQIKAHPWHKIFHKRMPPEAVDLVSRLLQYSPNLRCSALDALVHPFF aer+vg+gsfgvvfqakcletgetvaikkvlqdkryknrelq+mrlldhpnvv+lkh+ffsttekdelylnlvleyvpet++rv+khy+klnqr pliyvkly yqi+ral+yih+++gvchrdikpqnllvnp+thq+klcdfgsakvlvkgepni yicsryyrapelifgateyttaidiwsagcvlaelllgqplfpgesgvdqlveiikvlgtptreeikcmnpnyte+kfpqikahpwhk+f+kr+ppeavdlvsrllqyspnlrc+al+alvhpff aervvgtgsfgvvfqakcletgetvaikkvlqdkryknrelqimrlldhpnvvalkhlffsttekdelylnlvleyvpetvyrvakhysklnqrlpliyvklytyqicralayihkvvgvchrdikpqnllvnpkthqlklcdfgsakvlvkgepnisyicsryyrapelifgateyttaidiwsagcvlaelllgqplfpgesgvdqlveiikvlgtptreeikcmnpnytefkfpqikahpwhkvfkkrlppeavdlvsrllqyspnlrctalealvhpff 614.5 1.6e-187 CMGC_GSK 558 Cluster-782.2778-1F PF00069.22 139 423 1 264 YMAERIVGHGSFGVVFQAKCLETGETVAIKKVLQDKRYKN------RELQTMRLLDHPNVVSLKHCFFStteKDELYlnLVLEYVPET-LHRVVKHYNKLNQRtpliYVKLYSYQIFRALSYIHrGIGVCHRDIKPQNLLVNpHTHQVKLCDFGSAKVLVKGEPNIYYICSRYYRAPELIfGATEYTTAIDIWSAGCVLAELLLGQPLFP---GES----GVDQLVEIIKVLGtptREEIKCMNP--NyteykfpqikahpwhkifhkrmPPEAVDLVSRLLQYSPNLRCSALDALVHPFF y ++ +G GsfG+V++a+ etg++vA+Kk+ ++k+ k+ rE++ ++ l+hpn+v l+++f + kdely lvleyv+++ l++++++ +l+++ +k + +qi+++l+y+H g++HrD+Kp+N+L++ ++ ++K++DFG ak l ++++ ++++r+Y+APE++ +++ey++++D+Ws+G++l+ell g+p+f+ g++ +dql++i+k+lg ++ k ++ ++ea dl+++ll++ p+ R++a ++l hp++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee...kdely..lvleyveggeladllsrkgslsee....eakkiakqilegleylH.skgiiHrDlKpeNiLid.ekgelKitDFGlakelessskltsfvgtreYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg...etkeklpeasel......................seeakdllkkllkkdpkkRltaeellqhpyl 212.0 6.3e-65 Protein kinase domain 558 Cluster-782.2778-1F PF07714.14 142 344 4 211 ERIVGHGSFGVVFQAKCL----ETGETVAIKKVLQDKRYK-----NRELQTMRLLDHPNVVSLKHCFFsttEKDElyLNLVLEYVPE-TLHRVVKHYNKlNQRTPLIYVKLYSYQIFRALSYIHRgIGVCHRDIKPQNLLVNpHTHQVKLCDFGSAKVLVKGE---PNIYYICSRYYRAPELIFGATeYTTAIDIWSAGCVLAELLL-GQPLFPGES ++ +G+G+fG V+++++ ++ +va+K++ ++++ + +e+++m+ l+hpn+v+l + ++++ l +v+eyv++ +L++ +++ ++ ++++ l + +++qi ++++y+++ + Hrd+ +N L++ ++++vk++DfG a+ + k + + ++ + apE ++ + +t++ D+Ws G +l E++ g+ +pg s gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvct...keep..llivteyvegGdLlkfLrkkee.kekltlkdllsfalqiAkGmeyLes.kklvHrdlaarNvLls.enkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekk.ftsksDvWsfGvllwEiftlgeepypgls 85.6 2.2e-26 Protein tyrosine kinase 558 Cluster-782.2779-0F CMGC_GSK 317 450 150 283 QVKGEPNIYYICSRYYRAPELIFGATEYTTAIDIWSAGCVLAELLLGQPLFPGESGVDQLVEIIKVLGTPTREEIKCMNPNYTEYKFPQIKAHPWHKIFHKRMPPEAVDLVSRLLQYSPNLRCSALDALVHPFF vkgepni yicsryyrapelifgateyttaidiwsagcvlaelllgqplfpgesgvdqlveiikvlgtptreeikcmnpnyte+kfpqikahpwhk+f+kr+ppeavdlvsrllqyspnlrc+al+alvhpff lvkgepnisyicsryyrapelifgateyttaidiwsagcvlaelllgqplfpgesgvdqlveiikvlgtptreeikcmnpnytefkfpqikahpwhkvfkkrlppeavdlvsrllqyspnlrctalealvhpff 288.9 2.9e-88 CMGC_GSK 585 Cluster-782.2779-0F PF00069.22 326 450 157 264 YICSRYYRAPELIfGATEYTTAIDIWSAGCVLAELLLGQPLFP---GES----GVDQLVEIIKVLGtptREEIKCMNP--NyteykfpqikahpwhkifhkrmPPEAVDLVSRLLQYSPNLRCSALDALVHPFF ++++r+Y+APE++ +++ey++++D+Ws+G++l+ell g+p+f+ g++ +dql++i+k+lg ++ k ++ ++ea dl+++ll++ p+ R++a ++l hp++ fvgtreYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg...etkeklpeasel......................seeakdllkkllkkdpkkRltaeellqhpyl 75.7 2.5e-23 Protein kinase domain 585 Cluster-782.2779-1F CMGC_GSK 141 291 1 151 AERIVGHGSFGVVFQAKCLETGETVAIKKVLQDKRYKNRELQTMRLLDHPNVVSLKHCFFSTTEKDELYLNLVLEYVPETLHRVVKHYNKLNQRTPLIYVKLYSYQIFRALSYIHRGIGVCHRDIKPQNLLVNPHTHQVKLCDFGSAKVLV aer+vg+gsfgvvfqakcletgetvaikkvlqdkryknrelq+mrlldhpnvv+lkh+ffsttekdelylnlvleyvpet++rv+khy+klnqr pliyvkly yqi+ral+yih+++gvchrdikpqnllvnp+thq+klcdfgsakvlv aervvgtgsfgvvfqakcletgetvaikkvlqdkryknrelqimrlldhpnvvalkhlffsttekdelylnlvleyvpetvyrvakhysklnqrlpliyvklytyqicralayihkvvgvchrdikpqnllvnpkthqlklcdfgsakvlv 302.3 2.4e-92 CMGC_GSK 585 Cluster-782.2779-1F PF00069.22 139 290 1 148 YMAERIVGHGSFGVVFQAKCLETGETVAIKKVLQDKRYKN------RELQTMRLLDHPNVVSLKHCFFStteKDELYlnLVLEYVPET-LHRVVKHYNKLNQRtpliYVKLYSYQIFRALSYIHrGIGVCHRDIKPQNLLVNpHTHQVKLCDFGSAKVL y ++ +G GsfG+V++a+ etg++vA+Kk+ ++k+ k+ rE++ ++ l+hpn+v l+++f + kdely lvleyv+++ l++++++ +l+++ +k + +qi+++l+y+H g++HrD+Kp+N+L++ ++ ++K++DFG ak l yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee...kdely..lvleyveggeladllsrkgslsee....eakkiakqilegleylH.skgiiHrDlKpeNiLid.ekgelKitDFGlakel 117.6 3.9e-36 Protein kinase domain 585 Cluster-782.2779-1F PF07714.14 142 288 4 152 ERIVGHGSFGVVFQAKCL----ETGETVAIKKVLQDKRYK-----NRELQTMRLLDHPNVVSLKHCFFsttEKDElyLNLVLEYVPE-TLHRVVKHYNKlNQRTPLIYVKLYSYQIFRALSYIHRgIGVCHRDIKPQNLLVNpHTHQVKLCDFGSAK ++ +G+G+fG V+++++ ++ +va+K++ ++++ + +e+++m+ l+hpn+v+l + ++++ l +v+eyv++ +L++ +++ ++ ++++ l + +++qi ++++y+++ + Hrd+ +N L++ ++++vk++DfG a+ gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvct...keep..llivteyvegGdLlkfLrkkee.kekltlkdllsfalqiAkGmeyLes.kklvHrdlaarNvLls.enkvvkisDfGLar 63.5 1.2e-19 Protein tyrosine kinase 585 Cluster-782.2793-0F RLK-Pelle_LRR-II 200 287 1 88 KNILGKGGFGIVYKGCLQDGTVVAVKRLKDGNAIGGEIQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGKK knilGkGgfg vykG+l+dgt+vavkrlk+ ++ gge+qfqteve+islavhrnllrl+Gfc+t+ erllvyp+m+ngsvasrl+ +k knilGkGgfgkvykGrladgtlvavkrlkeeesaggelqfqtevelislavhrnllrliGfcttsterllvypymengsvasrlrelk 146.2 8.4e-45 RLK-Pelle_LRR-II 1690 Cluster-782.2793-0F PF00069.22 198 296 2 102 SSKNILGKGGFGIVYKGC-LQDGTVVAVKRLKDGNAIGGE-IQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGKKIFQVTQVTR + ++ lG+G+fG Vyk++ ++g vAvK++k +a + ++++E++++ h+n++rly+++ ++ e++lv ++++g++a++l+ k++++ +++ + ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakk 45.6 3.5e-14 Protein kinase domain 1690 Cluster-782.2793-0F PF07714.14 200 286 4 95 KNILGKGGFGIVYKGCLQ-----DGTVVAVKRLKDGNAIGGEIQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGK ++ lG+G fG V++g l+ + + vavK lk+++ + +f +e+++++ h+n+++l+g+c+ + l+v ++++G++ + L+ k gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk 42.9 2.2e-13 Protein tyrosine kinase 1690 Cluster-782.2793-2F RLK-Pelle_LRR-II 315 448 90 224 AKPPLDWGTRKRIALGAARGLLYLHEQCDPKIIHRDVKAANILLDDYCEAVVGDFGLAKLLDHHDSHITTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGQRALEFGKGANQKGAML-DWVSTTRNQ +kp+ldw trkrialGaarGl ylheqcdpkiihrdvkaanilld+++eavvgdfglaklld++dsh+ttavrGtvGhiapeylstG+ssektdvfG+GilllelitGqrale+++ a++++++l dwv + +++ gkpaldwetrkrialGaarGlsylheqcdpkiihrdvkaanilldeefeavvgdfglaklldkkdshvttavrGtvGhiapeylstGkssektdvfGyGilllelitGqralelsrlaededvllldwvkklkke 242.5 3.7e-74 RLK-Pelle_LRR-II 1689 Cluster-782.2793-2F PF00069.22 323 439 99 210 TRKRIALGAARGLLYLHEQCdpkIIHRDVKAANILLDDYCEAVVGDFGLAKLLDHHDShiTTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGQRALEFGKGANQKGAML + k+ia ++gl ylH+++ iiHrD+K +NiL+d+ e ++DFGlak l+++ + +t + gt +APE l++ + s+k+Dv++ G++l+el+tg+ ++ kg +++ ++l eakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekel 80.0 1.1e-24 Protein kinase domain 1689 Cluster-782.2793-2F PF07714.14 318 424 100 205 PLDWGTRKRIALGAARGLLYLHEQcdpKIIHRDVKAANILLDDYCEAVVGDFGLAKLL-DHHDSHITTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELIT-GQR +l+ + ++al A+G+ yL+++ k++Hrd+ a N+Ll++ + ++DfGLa+ + ++++ + ++ + v +apE l++++ ++k+Dv+ fG+ll E++t g++ kltlkdllsfalqiAkGmeyLesk...klvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgee 66.5 1.4e-20 Protein tyrosine kinase 1689 Cluster-782.2794-0F RLK-Pelle_LRR-II 200 287 1 88 KNILGKGGFGIVYKGCLQDGTVVAVKRLKDGNAIGGEIQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGKK knilGkGgfg vykG+l+dgt+vavkrlk+ ++ gge+qfqteve+islavhrnllrl+Gfc+t+ erllvyp+m+ngsvasrl+ +k knilGkGgfgkvykGrladgtlvavkrlkeeesaggelqfqtevelislavhrnllrliGfcttsterllvypymengsvasrlrelk 147.2 4e-45 RLK-Pelle_LRR-II 925 Cluster-782.2794-0F PF00069.22 198 296 2 102 SSKNILGKGGFGIVYKGC-LQDGTVVAVKRLKDGNAIGGE-IQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGKKIFQVTQVTR + ++ lG+G+fG Vyk++ ++g vAvK++k +a + ++++E++++ h+n++rly+++ ++ e++lv ++++g++a++l+ k++++ +++ + ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakk 46.7 1.7e-14 Protein kinase domain 925 Cluster-782.2794-0F PF07714.14 200 286 4 95 KNILGKGGFGIVYKGCLQ-----DGTVVAVKRLKDGNAIGGEIQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGK ++ lG+G fG V++g l+ + + vavK lk+++ + +f +e+++++ h+n+++l+g+c+ + l+v ++++G++ + L+ k gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk 44.1 1e-13 Protein tyrosine kinase 925 Cluster-782.2794-2F RLK-Pelle_LRR-II 315 424 90 199 AKPPLDWGTRKRIALGAARGLLYLHEQCDPKIIHRDVKAANILLDDYCEAVVGDFGLAKLLDHHDSHITTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGQR +kp+ldw trkrialGaarGl ylheqcdpkiihrdvkaanilld+++eavvgdfglaklld++dsh+ttavrGtvGhiapeylstG+ssektdvfG+GilllelitGqr gkpaldwetrkrialGaarGlsylheqcdpkiihrdvkaanilldeefeavvgdfglaklldkkdshvttavrGtvGhiapeylstGkssektdvfGyGilllelitGqr 220.4 1.9e-67 RLK-Pelle_LRR-II 924 Cluster-782.2794-2F PF00069.22 323 423 99 194 TRKRIALGAARGLLYLHEQCdpkIIHRDVKAANILLDDYCEAVVGDFGLAKLLDHHDShiTTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGQ + k+ia ++gl ylH+++ iiHrD+K +NiL+d+ e ++DFGlak l+++ + +t + gt +APE l++ + s+k+Dv++ G++l+el+tg+ eakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgk 77.3 7.7e-24 Protein kinase domain 924 Cluster-782.2794-2F PF07714.14 318 424 100 205 PLDWGTRKRIALGAARGLLYLHEQcdpKIIHRDVKAANILLDDYCEAVVGDFGLAKLL-DHHDSHITTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELIT-GQR +l+ + ++al A+G+ yL+++ k++Hrd+ a N+Ll++ + ++DfGLa+ + ++++ + ++ + v +apE l++++ ++k+Dv+ fG+ll E++t g++ kltlkdllsfalqiAkGmeyLesk...klvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgee 67.8 5.9e-21 Protein tyrosine kinase 924 Cluster-782.2795-0F RLK-Pelle_LRR-II 367 500 90 224 AKPPLDWGTRKRIALGAARGLLYLHEQCDPKIIHRDVKAANILLDDYCEAVVGDFGLAKLLDHHDSHITTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGQRALEFGKGANQKGAML-DWVSTTRNQ +kp+ldw trkrialGaarGl ylheqcdpkiihrdvkaanilld+++eavvgdfglaklld++dsh+ttavrGtvGhiapeylstG+ssektdvfG+GilllelitGqrale+++ a++++++l dwv + +++ gkpaldwetrkrialGaarGlsylheqcdpkiihrdvkaanilldeefeavvgdfglaklldkkdshvttavrGtvGhiapeylstGkssektdvfGyGilllelitGqralelsrlaededvllldwvkklkke 242.1 4.8e-74 RLK-Pelle_LRR-II 2119 Cluster-782.2795-0F PF00069.22 198 295 2 101 SSKNILGKGGFGIVYKGC-LQDGTVVAVKRLKDGNAIGGE-IQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGKKIFQVTQVT + ++ lG+G+fG Vyk++ ++g vAvK++k +a + ++++E++++ h+n++rly+++ ++ e++lv ++++g++a++l+ k++++ +++ ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeak 44.9 6.2e-14 Protein kinase domain 2119 Cluster-782.2795-0F PF00069.22 375 491 99 210 TRKRIALGAARGLLYLHEQCdpkIIHRDVKAANILLDDYCEAVVGDFGLAKLLDHHDShiTTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGQRALEFGKGANQKGAML + k+ia ++gl ylH+++ iiHrD+K +NiL+d+ e ++DFGlak l+++ + +t + gt +APE l++ + s+k+Dv++ G++l+el+tg+ ++ kg +++ ++l eakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekel 79.5 1.6e-24 Protein kinase domain 2119 Cluster-782.2795-0F PF07714.14 200 476 4 205 KNILGKGGFGIVYKGCLQ-----DGTVVAVKRLKDGNAIGGEIQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGKkifqvtqvtrtpystnc*kanfcsiklkhninhts*ialhshphi*wfllvltlriqilae*kftcpqakyfhvcclyiLAKPPLDWGTRKRIALGAARGLLYLHEQcdpKIIHRDVKAANILLDDYCEAVVGDFGLAKLL-DHHDSHITTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELIT-GQR ++ lG+G fG V++g l+ + + vavK lk+++ + +f +e+++++ h+n+++l+g+c+ + l+v ++++G++ + L+ k +k++l+ + ++al A+G+ yL+++ k++Hrd+ a N+Ll++ + ++DfGLa+ + ++++ + ++ + v +apE l++++ ++k+Dv+ fG+ll E++t g++ gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk...............................................................................eekekltlkdllsfalqiAkGmeyLesk...klvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgee 117.3 4.5e-36 Protein tyrosine kinase 2119 Cluster-782.2810-1F CMGC_CLK 168 382 114 327 AIVMHDLRLIHTDLKPENILLVSPECTKVPDYKslSRSPKDGSYYKRIPKSSAIKVIDFGSTTYEKKDQTYIVSTRHYRAPEVILGLGWSYPCDIWSVGCILVELCSGEAMFQTHENLEHLAMMERVLGPMPQHMLKRAGRCAEKYVRRG-RLDWPEGATSRDSIKAVLKLHRLQNLIMQHVDHSAGDLIHLVQGLLRYDPSDRLTAREALRHPFF mh+lrlihtdlkpenillvs e+ kvpdyk srs+k+g+++kr+pkssaik+idfgs+t+++++++++vstrhyrapevilglgwsypcd+wsvgcilvelcsgea+fqthenlehlammervlgp+p+hm+kra r aeky+rrg rl+wpega+sr+s+kav kl+rl+nli+++vdhsag+li+l+qgll+ydps+rlta+eal+hpff vaymhelrlihtdlkpenillvsseyvkvpdyk..srsskegkafkrlpkssaiklidfgsatfdeqehssvvstrhyrapevilglgwsypcdlwsvgcilvelcsgealfqthenlehlammervlgplpehmikradrraekyfrrgarlnwpegaasreslkavkklprlknlilkkvdhsagelidllqgllkydpserltakealkhpff 398.5 1.4e-121 CMGC_CLK 525 Cluster-782.2810-1F PF00069.22 168 382 111 264 AIVMHDLRLIHTDLKPENILLVSpectkvpdykslsrspkdgsyykripkSSAIKVIDFGSTTYEKKDQ--TYIVSTRHYRAPEVILGLGWSYPCDIWSVGCILVELCSGEAMFQTHE-------NLEHLAMMERVLGpMPQHMLKRAGRCaekyvrrgrldwpegatsrdsikavlklhrlqnlimqhvdhsAGDLIHLVQGLLRYDPSDRLTAREALRHPFF +H+ ++iH DlKpeNiL+ + ++ +K++DFG + ++++ t +v tr+Y+APEv+ + + s ++D+Ws+G+il+el +g+ +f+ ++ +l++l ++ ++lg + l++a + ++++l++ ll++dp++Rlta+e+l+hp++ leylHskgiiHrDlKpeNiLide...........................kgelKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.etkeklpeasel..........................................seeakdllkkllkkdpkkRltaeellqhpyl 104.2 4.8e-32 Protein kinase domain 525 Cluster-782.2810-1F PF07714.14 171 293 120 221 MHDLRLIHTDLKPENILLVSpectkvpdykslsrspkdgsyykripkSSAIKVIDFGSTTYEKKDQTYIVST-----RHYRAPEVILGLGWSYPCDIWSVGCILVELCS-GEAMFQTHENLEHLAMMER +++ +l+H dl N+Ll + ++ +k+ DfG + +kd++y +++ ++ apE++ + D+Ws G +l E+++ ge +++ +n e l+++++ LeskklvHrdlaarNvLlse...........................nkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevleklke 30.9 1.1e-09 Protein tyrosine kinase 525 Cluster-782.2811-0F CMGC_CLK 110 224 1 115 YKINSKMGEGTFGQVLECWDRERKEMVAIKIVRGLKKYRDAAMIEVDVLQQLGKHDKGGNRCVQIRNWFDYRNHICIVFEKLGPSLYDFLRKNNYRSFHIDLVREIGRQLLECVA yki skmgegtfg+vlecwdrerke+vaik+vr++kkyrdaamie+dvl++l+k+dk g+rcvq+++wfdyrnhicivfeklgpslydflrkn+yrsf idlvr++grqlle+va ykilskmgegtfgrvlecwdrerkelvaikvvrsikkyrdaamieidvlkklakndklgsrcvqlkewfdyrnhicivfeklgpslydflrknkyrsfpidlvrdlgrqllesva 224.7 1.1e-68 CMGC_CLK 651 Cluster-782.2811-0F PF00069.22 110 224 1 112 YKINSKMGEGTFGQVLECWDRERKEMVAIKIVRGLKKYR---DAAMIEVDVLQQLGkHDkggnRCVQIRNWFDYRNHICIVFEKLG-PSLYDFLRknNYRSFHIDLVREIGRQLLECVA y+ ++k+GeG+fG+V+++ ++e++++vA+K+++ k+ ++++ E+ +l++l h+ + v++ ++f +++++v+e + +l d+l+ + s+ + +++i +q+le ++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklk.hp....nivrlyevfeekdelylvleyveggeladlls..rkgslseeeakkiakqilegle 40.6 1.2e-12 Protein kinase domain 651 Cluster-782.2811-0F PF07714.14 111 209 2 103 KINSKMGEGTFGQVLECWDR----ERKEMVAIKIVRGLKK--YRDAAMIEVDVLQQLgKHDKggnrCVQIRNWFDYRNHICIVFEKL-GPSLYDFLRKN-NYRSFHI ++++k+GeG+fG+V e+ + +++ va+K+++ ++ +++ + e++++++l kh++ v++ + +++++iv+e + g +L +fLrk+ + +++++ elgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkkl.khpn....ivkllgvctkeepllivteyvegGdLlkfLrkkeekekltl 24.6 9.1e-08 Protein tyrosine kinase 651 Cluster-782.2811-1F CMGC_CLK 296 508 116 327 VMHDLRLIHTDLKPENILLVSPECTKVPDYKslSRSPKDGSYYKRIPKSSAIKVIDFGSTTYEKKDQTYIVSTRHYRAPEVILGLGWSYPCDIWSVGCILVELCSGEAMFQTHENLEHLAMMERVLGPMPQHMLKRAGRCAEKYVRRG-RLDWPEGATSRDSIKAVLKLHRLQNLIMQHVDHSAGDLIHLVQGLLRYDPSDRLTAREALRHPFF mh+lrlihtdlkpenillvs e+ kvpdyk srs+k+g+++kr+pkssaik+idfgs+t+++++++++vstrhyrapevilglgwsypcd+wsvgcilvelcsgea+fqthenlehlammervlgp+p+hm+kra r aeky+rrg rl+wpega+sr+s+kav kl+rl+nli+++vdhsag+li+l+qgll+ydps+rlta+eal+hpff ymhelrlihtdlkpenillvsseyvkvpdyk..srsskegkafkrlpkssaiklidfgsatfdeqehssvvstrhyrapevilglgwsypcdlwsvgcilvelcsgealfqthenlehlammervlgplpehmikradrraekyfrrgarlnwpegaasreslkavkklprlknlilkkvdhsagelidllqgllkydpserltakealkhpff 397.0 4.1e-121 CMGC_CLK 651 Cluster-782.2811-1F PF00069.22 296 508 113 264 VMHDLRLIHTDLKPENILLVSpectkvpdykslsrspkdgsyykripkSSAIKVIDFGSTTYEKKDQ--TYIVSTRHYRAPEVILGLGWSYPCDIWSVGCILVELCSGEAMFQTHE-------NLEHLAMMERVLGpMPQHMLKRAGRCaekyvrrgrldwpegatsrdsikavlklhrlqnlimqhvdhsAGDLIHLVQGLLRYDPSDRLTAREALRHPFF +H+ ++iH DlKpeNiL+ + ++ +K++DFG + ++++ t +v tr+Y+APEv+ + + s ++D+Ws+G+il+el +g+ +f+ ++ +l++l ++ ++lg + l++a + ++++l++ ll++dp++Rlta+e+l+hp++ ylHskgiiHrDlKpeNiLide...........................kgelKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.etkeklpeasel..........................................seeakdllkkllkkdpkkRltaeellqhpyl 102.9 1.2e-31 Protein kinase domain 651 Cluster-782.2811-1F PF07714.14 297 419 120 221 MHDLRLIHTDLKPENILLVSpectkvpdykslsrspkdgsyykripkSSAIKVIDFGSTTYEKKDQTYIVST-----RHYRAPEVILGLGWSYPCDIWSVGCILVELCS-GEAMFQTHENLEHLAMMER +++ +l+H dl N+Ll + ++ +k+ DfG + +kd++y +++ ++ apE++ + D+Ws G +l E+++ ge +++ +n e l+++++ LeskklvHrdlaarNvLlse...........................nkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevleklke 29.9 2.2e-09 Protein tyrosine kinase 651 Cluster-782.2877-1F RLK-Pelle_Extensin 230 497 2 269 ILGEGGFGLVYGGTLEDGRKVAVKVLKREDQQGSREFLAEVEMLSRLHHRNLVKLLGICAEDQCRSLVYELIPNGSVESHLHGVDKEVSPLDWHTRVKIALGAARALAYLHEDSSPRVIHRDFKSSNILLEHDFTPKVSDFGLARTAMEGGDKHVSTHVMGTFGYLAPEYAMTGHLLVKSDVYSYGVVLLELLTGRKPVDFSQPSGQENLVAWARPLLGTKEGLETIIDASLESNVPPDIIAKFAAIASMCVQPEVSHRPFMGEVVQA ++GeGgfG vy G+ledg++vavk+l+r+d+qg+refl+eve+lsrlhhrnlvkllGicae++ r lvyelipnGsveshlhg dk+ +pldw++r+kial+aar+laylheds+prvihrdfk+snille+dft+kvsdfGla++a+e+ ++++st+v+GtfGy+aPeyamtGhllvksdvysyGvvllell+GrkPvd ++p+gqenlv+warPll ++e+le+++d+sle++++ d +ak aaias+cvqpe+s+rp+mgevvqa vvGeGgfGkvykGvledgtevavkkltrddkqgereflvevellsrlhhrnlvkllGicaeeskrllvyelipnGsveshlhgsdkakapldwdarlkialdaarglaylhedsqprvihrdfkasnilleedftakvsdfGlakeasekakeeistrvlGtfGyvaPeyamtGhllvksdvysyGvvllellsGrkPvdmkrpegqenlvtwarPlltdrekleelvdpslegeyslddlakvaaiasvcvqpeaserplmgevvqa 471.3 7.1e-144 RLK-Pelle_Extensin 605 Cluster-782.2877-1F PF07714.14 228 498 4 260 SRILGEGGFGLVYGGTLE-----DGRKVAVKVLKREDQQG-SREFLAEVEMLSRLHHRNLVKLLGICAEDQCRSLVYELIPNGSVESHLHGVdKEVSPLDWHTRVKIALGAARALAYLHEDSsprVIHRDFKSSNILLEHDFTPKVSDFGLARTAMEGGDKHVSTHVMGTFGYLAPEYAMTGHLLVKSDVYSYGVVLLELLT-GRKPvdfsqpsgqenlvawaRPLLGTKEGLETIiDASLESNVPPDIIAKFAAIASMCVQPEVSHRPFMGEVVQAL ++ lGeG fG V+ gtl+ + kvavK+lk+e ++ ++efl e++++++l+h+n+vkllg+c +++ +v e++++G+++++L+ +e ++l+ ++ +++al A++++yL++ + ++Hrd + N+Ll+++ + k+sDfGLar+ ++ + +++++ + ++apE +++++ +ksDv+s+Gv+l E++t g++p p l ++e le++ +++ + + p ++ ++++ + + C++ + ++Rp + e+v+ l gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk.eekekltlkdllsfalqiAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep................ypglsneevlekl.kegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 164.1 2.4e-50 Protein tyrosine kinase 605 Cluster-782.2877-1F PF00069.22 227 496 3 260 ASRILGEGGFGLVYGGT-LEDGRKVAVKVLKREDQQGSRE--FLAEVEMLSRLHHRNLVKLLGICAEDQCRSLVYELIPNGSVESHLHgvdKEVSpLDWHTRVKIALGAARALAYLHEDSsprVIHRDFKSSNILLEHDFTPKVSDFGLARTAMEGGDkhvSTHVMGTFGYLAPEYAMTGHLLVKSDVYSYGVVLLELLTGRKPvdFSQPSGQENLVAWARPLLGTKEGLEtiiDASLESNVPPDIIAKFAAIASMCVQPEVSHRPFMGEVVQ + lGeG+fG Vy ++ e+g++vAvK++k+e+++ ++e +l+E+++l +l+h+n+v+l++++ e++ + lv e++++g+++++l+ +++s l+ ++ kia +++l+ylH+ + +iHrD K++NiL++++ K++DFGla+ + ++ + t+++gt YlAPE + + k+Dv+s+Gv+l+elltg+ p fs+ +g+e+ + ++ l + + l+ + +++++++ ++ ++ + + +++ + ++R+ + e++q kleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls...rkgs.lseeeakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkpp..fsgekgkekvekeldqlekilkilg...etkeklpeaselseeakdllkkllkkdpkkRltaeellq 160.0 4.5e-49 Protein kinase domain 605 Cluster-782.2878-1F RLK-Pelle_Extensin 253 520 2 269 ILGEGGFGLVYGGTLEDGRKVAVKVLKREDQQGSREFLAEVEMLSRLHHRNLVKLLGICAEDQCRSLVYELIPNGSVESHLHGVDKEVSPLDWHTRVKIALGAARALAYLHEDSSPRVIHRDFKSSNILLEHDFTPKVSDFGLARTAMEGGDKHVSTHVMGTFGYLAPEYAMTGHLLVKSDVYSYGVVLLELLTGRKPVDFSQPSGQENLVAWARPLLGTKEGLETIIDASLESNVPPDIIAKFAAIASMCVQPEVSHRPFMGEVVQA ++GeGgfG vy G+ledg++vavk+l+r+d+qg+refl+eve+lsrlhhrnlvkllGicae++ r lvyelipnGsveshlhg dk+ +pldw++r+kial+aar+laylheds+prvihrdfk+snille+dft+kvsdfGla++a+e+ ++++st+v+GtfGy+aPeyamtGhllvksdvysyGvvllell+GrkPvd ++p+gqenlv+warPll ++e+le+++d+sle++++ d +ak aaias+cvqpe+s+rp+mgevvqa vvGeGgfGkvykGvledgtevavkkltrddkqgereflvevellsrlhhrnlvkllGicaeeskrllvyelipnGsveshlhgsdkakapldwdarlkialdaarglaylhedsqprvihrdfkasnilleedftakvsdfGlakeasekakeeistrvlGtfGyvaPeyamtGhllvksdvysyGvvllellsGrkPvdmkrpegqenlvtwarPlltdrekleelvdpslegeyslddlakvaaiasvcvqpeaserplmgevvqa 471.2 7.8e-144 RLK-Pelle_Extensin 628 Cluster-782.2878-1F PF07714.14 251 521 4 260 SRILGEGGFGLVYGGTLE-----DGRKVAVKVLKREDQQG-SREFLAEVEMLSRLHHRNLVKLLGICAEDQCRSLVYELIPNGSVESHLHGVdKEVSPLDWHTRVKIALGAARALAYLHEDSsprVIHRDFKSSNILLEHDFTPKVSDFGLARTAMEGGDKHVSTHVMGTFGYLAPEYAMTGHLLVKSDVYSYGVVLLELLT-GRKPvdfsqpsgqenlvawaRPLLGTKEGLETIiDASLESNVPPDIIAKFAAIASMCVQPEVSHRPFMGEVVQAL ++ lGeG fG V+ gtl+ + kvavK+lk+e ++ ++efl e++++++l+h+n+vkllg+c +++ +v e++++G+++++L+ +e ++l+ ++ +++al A++++yL++ + ++Hrd + N+Ll+++ + k+sDfGLar+ ++ + +++++ + ++apE +++++ +ksDv+s+Gv+l E++t g++p p l ++e le++ +++ + + p ++ ++++ + + C++ + ++Rp + e+v+ l gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk.eekekltlkdllsfalqiAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep................ypglsneevlekl.kegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 164.0 2.6e-50 Protein tyrosine kinase 628 Cluster-782.2878-1F PF00069.22 250 519 3 260 ASRILGEGGFGLVYGGT-LEDGRKVAVKVLKREDQQGSRE--FLAEVEMLSRLHHRNLVKLLGICAEDQCRSLVYELIPNGSVESHLHgvdKEVSpLDWHTRVKIALGAARALAYLHEDSsprVIHRDFKSSNILLEHDFTPKVSDFGLARTAMEGGDkhvSTHVMGTFGYLAPEYAMTGHLLVKSDVYSYGVVLLELLTGRKPvdFSQPSGQENLVAWARPLLGTKEGLEtiiDASLESNVPPDIIAKFAAIASMCVQPEVSHRPFMGEVVQ + lGeG+fG Vy ++ e+g++vAvK++k+e+++ ++e +l+E+++l +l+h+n+v+l++++ e++ + lv e++++g+++++l+ +++s l+ ++ kia +++l+ylH+ + +iHrD K++NiL++++ K++DFGla+ + ++ + t+++gt YlAPE + + k+Dv+s+Gv+l+elltg+ p fs+ +g+e+ + ++ l + + l+ + +++++++ ++ ++ + + +++ + ++R+ + e++q kleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls...rkgs.lseeeakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkpp..fsgekgkekvekeldqlekilkilg...etkeklpeaselseeakdllkkllkkdpkkRltaeellq 159.9 5e-49 Protein kinase domain 628 Cluster-782.2879-2F RLK-Pelle_Extensin 581 848 2 269 ILGEGGFGLVYGGTLEDGRKVAVKVLKREDQQGSREFLAEVEMLSRLHHRNLVKLLGICAEDQCRSLVYELIPNGSVESHLHGVDKEVSPLDWHTRVKIALGAARALAYLHEDSSPRVIHRDFKSSNILLEHDFTPKVSDFGLARTAMEGGDKHVSTHVMGTFGYLAPEYAMTGHLLVKSDVYSYGVVLLELLTGRKPVDFSQPSGQENLVAWARPLLGTKEGLETIIDASLESNVPPDIIAKFAAIASMCVQPEVSHRPFMGEVVQA ++GeGgfG vy G+ledg++vavk+l+r+d+qg+refl+eve+lsrlhhrnlvkllGicae++ r lvyelipnGsveshlhg dk+ +pldw++r+kial+aar+laylheds+prvihrdfk+snille+dft+kvsdfGla++a+e+ ++++st+v+GtfGy+aPeyamtGhllvksdvysyGvvllell+GrkPvd ++p+gqenlv+warPll ++e+le+++d+sle++++ d +ak aaias+cvqpe+s+rp+mgevvqa vvGeGgfGkvykGvledgtevavkkltrddkqgereflvevellsrlhhrnlvkllGicaeeskrllvyelipnGsveshlhgsdkakapldwdarlkialdaarglaylhedsqprvihrdfkasnilleedftakvsdfGlakeasekakeeistrvlGtfGyvaPeyamtGhllvksdvysyGvvllellsGrkPvdmkrpegqenlvtwarPlltdrekleelvdpslegeyslddlakvaaiasvcvqpeaserplmgevvqa 469.9 1.9e-143 RLK-Pelle_Extensin 956 Cluster-782.2879-2F PF07714.14 579 849 4 260 SRILGEGGFGLVYGGTLE-----DGRKVAVKVLKREDQQG-SREFLAEVEMLSRLHHRNLVKLLGICAEDQCRSLVYELIPNGSVESHLHGVdKEVSPLDWHTRVKIALGAARALAYLHEDSsprVIHRDFKSSNILLEHDFTPKVSDFGLARTAMEGGDKHVSTHVMGTFGYLAPEYAMTGHLLVKSDVYSYGVVLLELLT-GRKPvdfsqpsgqenlvawaRPLLGTKEGLETIiDASLESNVPPDIIAKFAAIASMCVQPEVSHRPFMGEVVQAL ++ lGeG fG V+ gtl+ + kvavK+lk+e ++ ++efl e++++++l+h+n+vkllg+c +++ +v e++++G+++++L+ +e ++l+ ++ +++al A++++yL++ + ++Hrd + N+Ll+++ + k+sDfGLar+ ++ + +++++ + ++apE +++++ +ksDv+s+Gv+l E++t g++p p l ++e le++ +++ + + p ++ ++++ + + C++ + ++Rp + e+v+ l gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk.eekekltlkdllsfalqiAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep................ypglsneevlekl.kegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 162.8 6.2e-50 Protein tyrosine kinase 956 Cluster-782.2879-2F PF00069.22 578 847 3 260 ASRILGEGGFGLVYGGT-LEDGRKVAVKVLKREDQQGSRE--FLAEVEMLSRLHHRNLVKLLGICAEDQCRSLVYELIPNGSVESHLHgvdKEVSpLDWHTRVKIALGAARALAYLHEDSsprVIHRDFKSSNILLEHDFTPKVSDFGLARTAMEGGDkhvSTHVMGTFGYLAPEYAMTGHLLVKSDVYSYGVVLLELLTGRKPvdFSQPSGQENLVAWARPLLGTKEGLEtiiDASLESNVPPDIIAKFAAIASMCVQPEVSHRPFMGEVVQ + lGeG+fG Vy ++ e+g++vAvK++k+e+++ ++e +l+E+++l +l+h+n+v+l++++ e++ + lv e++++g+++++l+ +++s l+ ++ kia +++l+ylH+ + +iHrD K++NiL++++ K++DFGla+ + ++ + t+++gt YlAPE + + k+Dv+s+Gv+l+elltg+ p fs+ +g+e+ + ++ l + + l+ + +++++++ ++ ++ + + +++ + ++R+ + e++q kleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls...rkgs.lseeeakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkpp..fsgekgkekvekeldqlekilkilg...etkeklpeaselseeakdllkkllkkdpkkRltaeellq 158.7 1.2e-48 Protein kinase domain 956 Cluster-782.2896-2R PEK_PEK 78 340 2 244 VIGEGSFGVVVKCNSKVDGGVyaVKKVPLLLLPYENIKREIVALRRMEHQNIVRYYTSWVESCIAGkydgpslncpCLYIQMEFCPKSLDAFLADPKfREDIDLKWRIFRQILDGLSHIHEKNLIHRDLCPNNIFLDKENNVKIGDFGLVKFLDSKGTSTKISNTDGNKLYQAPEIDPGYLmqgltsateveITQKVDIFSLGLILTDLMYSFpTEAARK-TAFSRLRRQRAPSHLH----DSLDSLELIWKLVDKDPSKRLATGDIK ++G Gs G v kC +++ + ++++ + ++ +e+ +l +++ n+V y+ w e + g +yi+me c ++L+ +l +k +++ ++ +F++i++g+ iHe+ ++hrdl P ni+ld+ nnvki+dfg ++ s+ ++ s+ g++ly +pe + g+l +++kvDi+slG+i+ +l++ + t+ +k ++s lr+++ +++++ d el+ kl+ +ps+R+++ +i+ llGkGseGevykCtkssapda..lessdvtkaskhkepeeVsilalLdnanvVdlyeaweenkvfg..........yvyilmeecartLseylnkrk.elnlqeslelFeeivegvkaiHeeGivhrdlkPsnilldsnnnvkiadfgsgsistsdsdesrgsreigtqlysspelkngsl...........vnekvDiyslGviyfElflpa.tsreekldklselrkrvkkedwkdilldWsgdaellkkllalepseRpsvseil 135.5 1.6e-41 PEK_PEK 775 Cluster-782.2896-2R PF00069.22 74 341 2 260 EEIYVIGEGSFGVVVKCNSKVDGGVYAVKKVPLLLLPY---ENIKREIVALRRMEHQNIVRYYTSWVEsciagkydgpslnCPCLYIQMEFCP-KSLDAFLADPKFREDIDLKwRIFRQILDGLSHIHEKNLIHRDLCPNNIFLDKENNVKIGDFGLVKFLDSKGTstkISNTDGNKLYQAPEIDpgylmqgltsaTEVEITQKVDIFSLGLILTDLMYSFPTEA--ARKTAFSRLRRQ-------------RAPSHLHDSLDSLELIWKLVDKDPSKRLATGDIKK e++ +GeGsfG+V+k+ +k +g +AvKk+ +++ rEi l++++h+nivr+y ++ e ly+ +e+++ ++l+ +l + + ++ ++k +i++qil gl+++H+k++iHrDl p+Ni++d+++++Ki+DFGl+k l+s+ + ++ g + Y APE+ +e e+++kvD++slG+il l++ p + +k+ +++ +q p + s + ++l+ kl++kdp+kRl ++++ ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee.............kdelylvleyveggeladllsrkgslseeeak.kiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvl...........keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellq 147.2 3.8e-45 Protein kinase domain 775 Cluster-782.2896-2R PF07714.14 78 341 6 258 VIGEGSFGVVVKCNSK----VDGGVYAVKKVPLLLLPY--ENIKREIVALRRMEHQNIVRYYTSWVesciagK--YdgpslncpcLYIQMEFCPK-SLDAFLADP--KFREDIDLKWRIFRQILDGLSHIHEKNLIHRDLCPNNIFLDKENNVKIGDFGLVKFLDSKGTSTKISNTDGNKLYQAPEIDPGYLmqgltsateveITQKVDIFSLGLILTDLMY--SFPTEAARKTAF-SRLR-RQRAPSHLHDSLDSLELIWKLVDKDPSKRLATGDIKK +GeG+fG Vv+++ k + avK++ e++ +e+ +++++h+niv+++ + k l+i +e++++ +L+ fL + k + +++ + ++ +qi +G++++++k+l+Hrdl+ N++l++++ vki+DfGL + + ++ + +k ++++ + + apE+ +t+k D++s G +l ++ + p + +++ + ++l+ ++r + + + + el+ + +++dp++R ++ + klGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvct......keep.........llivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekk...........ftsksDvWsfGvllwEiftlgeepypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelve 87.3 6.5e-27 Protein tyrosine kinase 775 Cluster-782.2915-0R CMGC_CDK-PITSLRE 453 744 1 292 FERLNKIDEGTYGVVYRAKDKKTGEIVALKKVKMEKEREGFPLTSLREINVLLSFHHRSIVDVKEVVVGSNLDSIFMVMEYMEHDLKGLMETMKQPFSQSEVKCLMIQLLEGVKYLHDNWVLHRDLKTSNLLLNNRGELKICDFGLARQYGSPLKPYTQLVVTLWYRAPELLLGAKQYSTAIDMWSLGCIMAELLSKEPLFNGKTEFDQLDKIFKILGTPNETIWPGFSKLPGVKVNFVKHQYNLLRRKFPATSFTGSPVLSDAGFDLLNKLLTYDPEKRITAEAALNHEWF +e+lnkidegtygvvyra+dkktgeivalkkvk+ekeregfpltslrein+lls+hh sivdvkevvvgs+ldsif+v+ey+ehdlkgl+e+mk+pfsqsevkclm+qllegvkylhdnwvlhrdlktsnlllnnrgelkicdfglarqygsplk+ytq vvtlwyrapelllgak+ystaid+ws+gci+aell+keplf+gk+e+dqldkifk+lgtpne+iwpg+sklp++kv+f+k++yn lr+kf+a+sf+g++vls+agfdlln+lltydpekritae al+hewf yeklnkidegtygvvyrardkktgeivalkkvklekeregfpltslreinillslhhpsivdvkevvvgskldsiflvleylehdlkgllesmkrpfsqsevkclmlqllegvkylhdnwvlhrdlktsnlllnnrgelkicdfglarqygsplkeytqevvtlwyrapelllgakeystaidlwsvgcilaellakeplfdgkseidqldkifkvlgtpnekiwpglsklpnakvkftkqpynklrkkftassfaggavlseagfdllnrlltydpekritaeealkhewf 583.8 4e-178 CMGC_CDK-PITSLRE 954 Cluster-782.2915-0R PF00069.22 453 744 1 264 FERLNKIDEGTYGVVYRAKDKKTGEIVALKKVKMEKEREGFPLTSLREINVLLSFHHRSIVDVKEVVVGsnLDSIFMVMEYMEHD-LKGLMEtMKQPFSQSEVKCLMIQLLEGVKYLHDNWVLHRDLKTSNLLLNNRGELKICDFGLARQYGSPLKpYTQLVVTLWYRAPELLlGAKQYSTAIDMWSLGCIMAELLSKEPLFN---GKT----EFDQLDKIFKILGtPNETIWPGFSKLpgvkvnfvkhqynllrrkfpatsftgspvlSDAGFDLLNKLLTYDPEKRITAEAALNHEWF +e+l+k+ eG++G+Vy+a++k+tg+ivA+Kk+k ek+++ + lrEi++l +++h+ iv ++ev+ d++++v+ey+e++ l+ l++ k+ +s++e+k ++ q+leg++ylH++ ++HrDlK++N+L++++gelKi+DFGla+++ s k +t+ v+t +Y+APE+l ++++ys+++D+WslG+i++ell+++p+f+ gk+ e+dql ki+kilg +++ +p s+l s+ dll+kll++dp+kR+tae +l+h+++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee..kdelylvleyveggeladlls.rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk.ltsfvgtreYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.etkeklpeasel..............................seeakdllkkllkkdpkkRltaeellqhpyl 251.5 5.7e-77 Protein kinase domain 954 Cluster-782.2915-0R PF07714.14 456 651 4 206 LNKIDEGTYGVVYRAKDK----KTGEIVALKKVKMEKEREGfPLTSLREINVLLSFHHRSIVDVKEVVVgsNLDSIFMVMEYMEH-DLKGLMETM--KQPFSQSEVKCLMIQLLEGVKYLHDNWVLHRDLKTSNLLLNNRGELKICDFGLARQY--GSPLKPYTQLVVTLWYRAPELLLGAKqYSTAIDMWSLGCIMAELLS--KEP +k+ eG++G V++++ k k+ va+K++k e+++e l+e++++ +++h+ iv + v++ + +++++v+ey+e+ dL+ +++ k++++ +++ ++++q+ +G++yL+++ ++Hrdl + N Ll+++ ki+DfGLar+ + k ++ + + + apE l k ++++ D+Ws G ++ E+++ +ep gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateee.keefleeakimkklkhpnivkllgvct..keepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekk.ftsksDvWsfGvllwEiftlgeep 115.3 1.9e-35 Protein tyrosine kinase 954 Cluster-782.3091-0R CMGC_DYRK-YAK 251 500 96 340 HAVLKVCYNNTFSSMi*ILRGLALMKDAGIIHCDLKPENILLRTSVRAAEIKIIDFGSACMEDRTVYSYIQSRYYRSPEVLLGYQYTTAIDMWSFGCIVAELFLGLPLFPGASEFDLLRRMIKILGGQPPDSILRKAKNTSKFFKFVGSINHEESGQISTsnCSSMYQVLAEEEYEARESKKPAIGKEYFSHMNLEAIVTKYPYGkNLAHEDIVRESRMRLALIDFLRGLVQFDPAKRWSPLQASKHPFV l++ + ++fs +l +l+l++da+iihcdlkpenill +sv++ae+k+idfGsac+ed+tvysyiqsr+yrspevllGy+yttaidmws+Gc++aelflGlplfpGase+dll+r+i++lg+qppd +lr+aknt+kffk v++++++e+g++s +s yq+l+eee+eare+kkp+igk+yf++ +le +++ yp+ +l++e+ +e ++r +l+dfl+Gl+++dp+krwsplqa++hpf+ lkglslklvrlfskq..lldalsllrdariihcdlkpenilltesvksaelklidfGsacledktvysyiqsrfyrspevllGyryttaidmwslGcvaaelflGlplfpGaseydlllrlieklgkqppdyllreakntnkffklvsavpkaekgaksg..lksayqllteeeiearekkkpeigkryfakgaleeliasyplk.slseeevekekaarevlvdflkGllevdprkrwsplqaaqhpfi 387.6 4.3e-118 CMGC_DYRK-YAK 1035 Cluster-782.3091-0R PF00069.22 268 500 107 264 ILRGLALMKDAGIIHCDLKPENILLRTSVRaaeIKIIDFGSACMEDRT--VYSYIQSRYYRSPEVLLGYQYTTAIDMWSFGCIVAELFLGLPLFP---GAS----EFDLLRRMIKILGgqppdS---ILRKAKNTskffkfvgsinheesgqistsncssmyqvlaeeeyeareskkpaigkeyfshmnleaivtkypygknlahedivresrmRLALIDFLRGLVQFDPAKRWSPLQASKHPFV il+gl+ + ++giiH+DlKpeNiL+ ++ +Ki+DFG a+ +++ + s++ +r+Y++PEvl + +y++++D+Ws G+i++el+ g p+f+ g + e+d l +++kilg l++a++ ++d+l+ l++ dp kR++ ++ +hp++ ilegleylHskgiiHrDlKpeNiLidekge...lKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.....etkeklpeasel...............................................................................seeakdllkkllkkdpkkRltaeellqhpyl 108.7 2.1e-33 Protein kinase domain 1035 Cluster-782.3091-0R PF07714.14 270 370 115 218 RGLALMKDAGIIHCDLKPENILLRTsvrAAEIKIIDFGSACME--DRTVYSY---IQSRYYRSPEVLLGYQYTTAIDMWSFGCIVAELFL-GLPLFPGASEFDLLRR +G++ +++ ++H dl N+Ll++ +ki DfG a d + ++ + + +pE+l ++t++ D+WsfG ++ E+f g +pg s+ ++l++ kGmeyLeskklvHrdlaarNvLlse...nkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevlek 37.5 1e-11 Protein tyrosine kinase 1035 Cluster-782.3091-1R CMGC_DYRK-YAK 119 237 1 119 IVKDMLGHGTFGQVAKCWVPETNSFLAVKIIKNLPAYYQQALVEVSILTTLNKKFDPEDQNHIVRIYDYFVHQRHLCIAFELLDSNLYELIKLNQFRGLSLRIVRLFSKQVMHAFFVFR +vkd+lG+GtfGqvakc+v+etn+++avk+ikn+payy+qa ve+++l++lnkk dp+d++hivr++dyf +++hlci+felld+nlyel+k n+++glsl++vrlfskq+++a+ ++r vvkdllGsGtfGqvakcyveetneyvavkviknqpayytqarveigllkllnkkydpddkyhivrlldyflyeehlcivfelldenlyellkknslkglslklvrlfskqlldalsllr 189.0 1.1e-57 CMGC_DYRK-YAK 1035 Cluster-782.3091-1R PF00069.22 119 232 2 110 IVKDMLGHGTFGQVAKCWVPETNSFLAVKIIKNLPAYY---QQALVEVSILTTLNkkfdpedQNHIVRIYDYFVHQRHLCIAFELLDSN-LYELIKlnQ-FRgLSLRIVRLFSKQVMHA ++ lG G+fG+V k+ et+ AvK+ik+ a +++l E++il +l+ ++ivr+y++f ++++l++ +e+++ + l +l++ + ls + ++ + kq++++ ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklk.......hpnivrlyevfeekdelylvleyveggeladlls..rkgs.lseeeakkiakqileg 40.2 1.6e-12 Protein kinase domain 1035 Cluster-782.3143-0F RLK-Pelle_LRR-II 200 287 1 88 KNILGKGGFGIVYKGCLQDGTVVAVKRLKDGNAIGGEIQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGKK knilGkGgfg vykG+l+dgt+vavkrlk+ ++ gge+qfqteve+islavhrnllrl+Gfc+t+ erllvyp+m+ngsvasrl+ +k knilGkGgfgkvykGrladgtlvavkrlkeeesaggelqfqtevelislavhrnllrliGfcttsterllvypymengsvasrlrelk 145.9 1e-44 RLK-Pelle_LRR-II 1946 Cluster-782.3143-0F PF00069.22 198 296 2 102 SSKNILGKGGFGIVYKGC-LQDGTVVAVKRLKDGNAIGGE-IQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGKKIFQVTQVTR + ++ lG+G+fG Vyk++ ++g vAvK++k +a + ++++E++++ h+n++rly+++ ++ e++lv ++++g++a++l+ k++++ +++ + ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakk 45.4 4.2e-14 Protein kinase domain 1946 Cluster-782.3143-0F PF07714.14 200 286 4 95 KNILGKGGFGIVYKGCLQ-----DGTVVAVKRLKDGNAIGGEIQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGK ++ lG+G fG V++g l+ + + vavK lk+++ + +f +e+++++ h+n+++l+g+c+ + l+v ++++G++ + L+ k gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk 42.7 2.6e-13 Protein tyrosine kinase 1946 Cluster-782.3143-2F RLK-Pelle_LRR-II 315 448 90 224 AKPPLDWGTRKRIALGAARGLLYLHEQCDPKIIHRDVKAANILLDDYCEAVVGDFGLAKLLDHHDSHITTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGQRALEFGKGANQKGAML-DWVSTTRNQ +kp+ldw trkrialGaarGl ylheqcdpkiihrdvkaanilld+++eavvgdfglaklld++dsh+ttavrGtvGhiapeylstG+ssektdvfG+GilllelitGqrale+++ a++++++l dwv + +++ gkpaldwetrkrialGaarGlsylheqcdpkiihrdvkaanilldeefeavvgdfglaklldkkdshvttavrGtvGhiapeylstGkssektdvfGyGilllelitGqralelsrlaededvllldwvkklkke 242.2 4.4e-74 RLK-Pelle_LRR-II 1945 Cluster-782.3143-2F PF00069.22 323 439 99 210 TRKRIALGAARGLLYLHEQCdpkIIHRDVKAANILLDDYCEAVVGDFGLAKLLDHHDShiTTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGQRALEFGKGANQKGAML + k+ia ++gl ylH+++ iiHrD+K +NiL+d+ e ++DFGlak l+++ + +t + gt +APE l++ + s+k+Dv++ G++l+el+tg+ ++ kg +++ ++l eakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekel 79.8 1.4e-24 Protein kinase domain 1945 Cluster-782.3143-2F PF07714.14 318 424 100 205 PLDWGTRKRIALGAARGLLYLHEQcdpKIIHRDVKAANILLDDYCEAVVGDFGLAKLL-DHHDSHITTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELIT-GQR +l+ + ++al A+G+ yL+++ k++Hrd+ a N+Ll++ + ++DfGLa+ + ++++ + ++ + v +apE l++++ ++k+Dv+ fG+ll E++t g++ kltlkdllsfalqiAkGmeyLesk...klvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgee 66.3 1.7e-20 Protein tyrosine kinase 1945 Cluster-782.3155-0R CAMK_CAMKL-CHK1 68 239 1 172 YEVGRTIGEGTFAKVKFARNSETGQPVALKILDKDKVLKHKIAEQIKREVATMKLIKHPNVVRLYEVMASKTKIFIVLEFVTGGELFDKIVNHGRMQEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDAAGNLKVSDFGLSALSQQVKDDGLLHTTCGTPNYVAPEV ye+Gr++Gegtfakvk+ar+ etg+ va+k+ldk+kvlk+k++eqikre++++kl++hpnvvrl+ev+a+k+ki++vle+v+GGelf+ki+++gr++edearkyfqqli+avdychsrgvyhrdlkpenllld++gnlkvsdfGlsal++q+++dgllhttcGtP+yvaPev yelGrllGegtfakvklardletgesvaikvldkekvlkaklveqikreisvlklvrhpnvvrllevlatkskiylvleyvkGGelfekiakkgrlkedearkyfqqlisavdychsrgvyhrdlkpenllldekgnlkvsdfGlsalaeqlredgllhttcGtPayvaPev 305.1 2.8e-93 CAMK_CAMKL-CHK1 541 Cluster-782.3155-0R PF00069.22 68 239 1 168 YEVGRTIGEGTFAKVKFARNSETGQPVALKILDKDKVLKHKIaEQIKREVATMKLIKHPNVVRLYEVMASKTKIFIVLEFVTGGELFDKIVNHGRMQEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDAAGNLKVSDFGLSALSQQVKDdglLHTTCGTPNYVAPEV ye+ +++GeG+f+kV a+++etg+ vA+K+++k+k k k +++ rE++ +k +khpn+vrlyev+ +k+++++vle+v ggel+d + ++g ++e+ea+k+++q++++++y+Hs+g+ HrDlKpeN+L+d g+lK++DFGl++ ++ ++ l++ +gt++Y+APEv yekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEv 183.4 3.5e-56 Protein kinase domain 541 Cluster-782.3155-0R PF07714.14 70 239 3 177 VGRTIGEGTFAKVKFARNS----ETGQPVALKILDKDKVLKHkiAEQIKREVATMKLIKHPNVVRLYEVMASKTKIFIVLEFVTGGELFDKIVNH---GRMQEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDAAGNLKVSDFGLSALSQQVKDDGLLHTTCGTPNYVAPEV +g+++GeG+f++V ++ + ++ + va+K+l++++ ++ e++ +e+++mk +khpn+v+l+ v+ ++ +++iv+e+v+gG+L + + ++ +++ ++ ++ +q+ ++++y +s+ + Hrdl N Ll+ k+sDfGL+ ++ ++ +++ +++apE+ lgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateee..keefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEs 99.2 1.5e-30 Protein tyrosine kinase 541 Cluster-782.3179-0R RLK-Pelle_RLCK-VIIa-1 199 395 1 198 NLIGEGGFGSVYKGRLD-SGQIVAVKQLNHQGLQGNQEFIVEVLMLSLLHHTNLVKLIGYCADGDQRLLIYEYMPRGSLENHLFDLSSDQEPLSWNIRLKIAVGAAHGLEYLHCQANPPVIYRDLKSSNILLDNDFNVKLSDFGLAKLGPVGENTHVSTRVMGTYGYCAPEYAMSGKLTLKSDIYSLGVVMLELITGR nl+GeGGfg+vykg+l+ +gq+vavkql+++GlqGn+ef+vevlmlsllhh+nlvkliGycadgdqrll+yey+p+Gsle+hlfdl++d+epl+wn r+kiavgaa+Gleylh +a+Ppviyrdlk+snilld+df+ klsdfGlaklgpvg++thvstrvmgtyGycaPeya++gklt+ksd+ys+Gvv+lelitGr nllGeGGfgrvykgklektgqvvavkqldrnGlqGnreflvevlmlsllhhpnlvkliGycadgdqrllvyeylplGsledhlfdlkedkepldwntrmkiavgaakGleylhekakPpviyrdlkasnilldedfkpklsdfGlaklgpvgdkthvstrvmgtyGycaPeyaktgkltvksdvysfGvvllelitGr 378.2 1.7e-115 RLK-Pelle_RLCK-VIIa-1 395 Cluster-782.3179-0R PF00069.22 197 395 3 194 IGNLIGEGGFGSVYKGR-LDSGQIVAVKQLNHQGLQGNQE--FIVEVLMLSLLHHTNLVKLIGYCADGDQRLLIYEYMPRGSLENHLFdlssDQEPLSWNIRLKIAVGAAHGLEYLHCQAnppVIYRDLKSSNILLDNDFNVKLSDFGLAKLGPVGENthvSTRVMGTYGYCAPEYAMSGKLTLKSDIYSLGVVMLELITGR + +GeG+fG+Vyk++ ++g+ivAvK+++++ + ++e ++ E+ +l l+h n+v+l++++ + d+++l+ ey++ g+l+++l ++ ls + kia ++gleylH++ +i+rDlK++NiL+d++ ++K++DFGlak +++ t ++gt Y+APE + + + k+D++slGv+++el+tg+ kleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls....rkgslseeeakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgk 157.0 3.9e-48 Protein kinase domain 395 Cluster-782.3179-0R PF07714.14 197 393 3 201 IGNLIGEGGFGSVYKGRLD-----SGQIVAVKQLNHQGLQG-NQEFIVEVLMLSLLHHTNLVKLIGYCADGDQRLLIYEYMPRGSLENHLFDLsSDQEPLSWNIRLKIAVGAAHGLEYLHCQAnppVIYRDLKSSNILLDNDFNVKLSDFGLAKLGPVGENTHVSTRVMGTYGYCAPEYAMSGKLTLKSDIYSLGVVMLELIT +g+ +GeG fG+V++g+l+ + + vavK+l+++ + ++ef+ e+ +++ l+h n+vkl+g c ++++ l++ ey++ G+L+++L + +++e+l+ + l++a+ A+G+eyL+ + ++ rdl + N+Ll+++ vk+sDfGLa+ ++++++++ + ++apE +++k+t ksD++s Gv++ E++t lgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk.eekekltlkdllsfalqiAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEift 146.4 6.3e-45 Protein tyrosine kinase 395 Cluster-782.3257-0R RLK-Pelle_LRK10L-2 7 94 25 110 AVKIMGKSIASGQEFISEVATIGRIHHVDIIRLISFCVQGSKHALVYEFMPN-G*LEKYIFPLQIpaSSNLSYSKMFEIALGVAKGVDY avk++ +s + g+efi+eva+igri+hv+i++l+ fc++gsk+alvye++pn l+kyif + ++ls++k++eialg+a+G++y avkllkeskgngeefinevasigrishvnivsllGfclegskralvyeylpngs.ldkyifsees..keslsleklleialgiarGley 91.5 4.7e-28 RLK-Pelle_LRK10L-2 94 Cluster-782.3257-0R PF07714.14 7 94 32 119 AVKIMGKSIASG--QEFISEVATIGRIHHVDIIRLISFCVQGSKHALVYEFMPNG*leKYIFPLQIP-ASSNLSYSKMFEIALGVAKGVDY avK++ ++ + +ef++e++++ +++h i++l+ +c++++++ +v e++++G + L+ ++++l++++++++al +AkG++y avKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegG...dLlkfLrkkeekekltlkdllsfalqiAkGmey 34.6 7.8e-11 Protein tyrosine kinase 94 Cluster-782.340-2R PEK_PEK 78 340 2 244 VIGEGSFGVVVKCNSKVDGGVyaVKKVPLLLLPYENIKREIVALRRMEHQNIVRYYTSWVESCIAGkydgpslncpCLYIQMEFCPKSLDAFLADPKfREDIDLKWRIFRQILDGLSHIHEKNLIHRDLCPNNIFLDKENNVKIGDFGLVKFLDSKGTSTKISNTDGNKLYQAPEIDPGYLmqgltsateveITQKVDIFSLGLILTDLMYSFpTEAARK-TAFSRLRRQRAPSHLH----DSLDSLELIWKLVDKDPSKRLATGDIK ++G Gs G v kC +++ + ++++ + ++ +e+ +l +++ n+V y+ w e + g +yi+me c ++L+ +l +k +++ ++ +F++i++g+ iHe+ ++hrdl P ni+ld+ nnvki+dfg ++ s+ ++ s+ g++ly +pe + g+l +++kvDi+slG+i+ +l++ + t+ +k ++s lr+++ +++++ d el+ kl+ +ps+R+++ +i+ llGkGseGevykCtkssapda..lessdvtkaskhkepeeVsilalLdnanvVdlyeaweenkvfg..........yvyilmeecartLseylnkrk.elnlqeslelFeeivegvkaiHeeGivhrdlkPsnilldsnnnvkiadfgsgsistsdsdesrgsreigtqlysspelkngsl...........vnekvDiyslGviyfElflpa.tsreekldklselrkrvkkedwkdilldWsgdaellkkllalepseRpsvseil 135.4 1.7e-41 PEK_PEK 801 Cluster-782.340-2R PF00069.22 74 341 2 260 EEIYVIGEGSFGVVVKCNSKVDGGVYAVKKVPLLLLPY---ENIKREIVALRRMEHQNIVRYYTSWVEsciagkydgpslnCPCLYIQMEFCP-KSLDAFLADPKFREDIDLKwRIFRQILDGLSHIHEKNLIHRDLCPNNIFLDKENNVKIGDFGLVKFLDSKGTstkISNTDGNKLYQAPEIDpgylmqgltsaTEVEITQKVDIFSLGLILTDLMYSFPTEA--ARKTAFSRLRRQ-------------RAPSHLHDSLDSLELIWKLVDKDPSKRLATGDIKK e++ +GeGsfG+V+k+ +k +g +AvKk+ +++ rEi l++++h+nivr+y ++ e ly+ +e+++ ++l+ +l + + ++ ++k +i++qil gl+++H+k++iHrDl p+Ni++d+++++Ki+DFGl+k l+s+ + ++ g + Y APE+ +e e+++kvD++slG+il l++ p + +k+ +++ +q p + s + ++l+ kl++kdp+kRl ++++ ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee.............kdelylvleyveggeladllsrkgslseeeak.kiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvl...........keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellq 147.1 4e-45 Protein kinase domain 801 Cluster-782.340-2R PF07714.14 78 341 6 258 VIGEGSFGVVVKCNSK----VDGGVYAVKKVPLLLLPY--ENIKREIVALRRMEHQNIVRYYTSWVesciagK--YdgpslncpcLYIQMEFCPK-SLDAFLADP--KFREDIDLKWRIFRQILDGLSHIHEKNLIHRDLCPNNIFLDKENNVKIGDFGLVKFLDSKGTSTKISNTDGNKLYQAPEIDPGYLmqgltsateveITQKVDIFSLGLILTDLMY--SFPTEAARKTAF-SRLR-RQRAPSHLHDSLDSLELIWKLVDKDPSKRLATGDIKK +GeG+fG Vv+++ k + avK++ e++ +e+ +++++h+niv+++ + k l+i +e++++ +L+ fL + k + +++ + ++ +qi +G++++++k+l+Hrdl+ N++l++++ vki+DfGL + + ++ + +k ++++ + + apE+ +t+k D++s G +l ++ + p + +++ + ++l+ ++r + + + + el+ + +++dp++R ++ + klGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvct......keep.........llivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekk...........ftsksDvWsfGvllwEiftlgeepypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelve 87.2 6.9e-27 Protein tyrosine kinase 801 Cluster-782.3418-1F CMGC_RCK 238 517 1 280 YKIIKEVGTGTFGSVWRALNKQSGEVVAIKKMKKKFYSWEECKNLREVKSLLKMNHPNIVKLKEVIRENDVLFFVFEYMECNLYQLMKDRKRLFSEAEVRTWCFQVFQGLAYMHQRGYFHRDLKPENLLVSKDIIKVADFGLAREIDSEPPYTEYVSTRWYRAPEILLRSPTYGPAVDMWAMGALMAELFTLRPLFPGSSDADEIYKICCVIGSPTKNRWPHGLDLASAISYQFPQVAGGDLSLLIPGVSEDAISLITSLCSWDPCKRPTALETLQHPFF yk++ke+g gtfgsvw+a+nk+++evvaikkmk+kfysweec nlrevksl k+nhpnivklkevirend+lffvfey+ecnlyql+kdr++ fseaevr+++fq++q+l+ymh+rGyfhrdlkpenllv+kd+ik+adfGlare++s+ppyteyvstrwyrape+ll+s++y +avd+wa+Ga++ael++lrplfpG+s++deiykic+v+G+p+++ +++gl+la++++++fpq++g +l+ lip +s++ai+li++lcswdp+krpta e+lqhpff ykvlkelgdgtfgsvwkainketnevvaikkmkrkfysweeclnlrevkslrklnhpnivklkevirendelffvfeylecnlyqlikdrekafseaevrnfafqilqaleymhkrGyfhrdlkpenllvtkdvikiadfGlarevsskppyteyvstrwyrapevllqssvytsavdlwavGailaellslrplfpGasevdeiykicsvlGtpdeqtfaeglklaeslkfkfpqlsgtklaelipsasaeaidlisklcswdpkkrptaaealqhpff 517.3 6.6e-158 CMGC_RCK 589 Cluster-782.3418-1F PF00069.22 238 517 1 264 YKIIKEVGTGTFGSVWRALNKQSGEVVAIKKMKKKFYSWEEC-KNLREVKSLLKMNHPNIVKLKEVIRENDVLFFVFEYMECN-LYQLMKdRKRLFSEAEVRTWCFQVFQGLAYMHQRGYFHRDLKPENLLVS-KDIIKVADFGLAREIDSEPPYTEYVSTRWYRAPEILlRSPTYGPAVDMWAMGALMAELFTLRPLFP---GSS----DADEIYKICCVIGsPTKNRWPHGLDLasaisyqfpqvaggdlsllipgvSEDAISLITSLCSWDPCKRPTALETLQHPFF y+ ++++G+G+fG+V +a++k++g+ vA+Kk+kk+ + ++ k lrE+k l k++hpniv+l+ev++e+d l++v+ey+e++ l +l++ rk +se+e++ ++ q+++gl+y+H++g +HrDlKpeN+L++ k+ +K++DFGla+e++s+ ++t++v tr+Y+APE+l ++ y+++vD+W++G +++el+t +p+f+ g++ ++d+++ki+ ++g +tk+ +p+ +l se+a++l+++l+++dp kR+ta e lqhp++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls.rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtreYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.etkeklpeasel.......................seeakdllkkllkkdpkkRltaeellqhpyl 247.3 1.1e-75 Protein kinase domain 589 Cluster-782.3418-1F PF07714.14 239 429 2 202 KIIKEVGTGTFGSVWRALNK----QSGEVVAIKKMKKKFYSWEECKNLREVKSLLKMNHPNIVKLKEVIRENDVLFFVFEYMEC-NLYQLMKDR--KRLFSEAEVRTWCFQVFQGLAYMHQRGYFHRDLKPENLLVS-KDIIKVADFGLAREIDSEPPYT----EYVSTRWYrAPEILLRSPtYGPAVDMWAMGALMAELFTL ++ k++G G+fG+V+++ k ++ va+K++k++ + e+ + l+e+k + k++hpnivkl v+ +++ l++v+ey+e +L + ++++ k+ ++ ++ +++q+ +G++y++++ + Hrdl N L+s ++++k++DfGLar+i ++ y+ + ++ +W+ apE+l ++ + + D+W+ G l+ E+ftl elgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWm.apEslkekk.ftsksDvWsfGvllwEiftl 125.7 1.3e-38 Protein tyrosine kinase 589 Cluster-782.3458-0R Group-Pl-3 1 70 188 258 ILYQLVTGKTPFTGNNQIQLLENILKSTELKFPLDAK-DLNPHCVDLCRKLLRPNPVERLTFEEFFNHPYL il+qlvtG++Pf+Gnn++qll+ni kstelkfp + + dl+p c+dlcrkllr npverl+feeff+h++l ilfqlvtGrpPfsGnnkvqllqnikkstelkfpeeiladlhpdcidlcrkllrknpverlsfeeffahkfl 93.9 6.4e-29 Group-Pl-3 576 Cluster-782.3458-0R PF00069.22 1 70 186 264 ILYQLVTGKTPFTGNNQIQ----------LLENILKSTELKFPLdAKDLNPHCVDLCRKLLRPNPVERLTFEEFFNHPYL ily+l+tgk+pf g+++ + + +il+ t++k+p a++l++++ dl++kll+ +p +Rlt+ee +hpyl ilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpe.aselseeakdllkkllkkdpkkRltaeellqhpyl 30.6 1.4e-09 Protein kinase domain 576 Cluster-782.348-0R TKL_CTR1-DRK-2 1 85 168 252 PEVLRNERSNEKCDVYSFGVILWELATLKLPWSGMNPMQVVGAVGFQNRRLDIPKEVDPLVARIIWECWQTDPSLRPSFAQLVMT pevlrne+++ek+dvysfGvilwel+t+k pw+++n+mqvvgavgfqnrrl+ipkevdp va++i +cw++dp+ rpsf++++ + pevlrneaadeksdvysfGvilwelvtekipweelnamqvvgavgfqnrrleipkevdpkvasliescwekdpkkrpsfseilek 143.7 6.2e-44 TKL_CTR1-DRK-2 191 Cluster-782.348-0R PF07714.14 1 86 175 260 PEVLRNERSNEKCDVYSFGVILWELAT-LKLPWSGMNPMQVVGAVgFQNRRLDIPKEVDPLVARIIWECWQTDPSLRPSFAQLVMTL pE+l++++ ++k Dv+sfGv+lwE++t + p++g+++++v+ ++ +++rl+ p+++ + +++++ +Cw++dp+ Rp+f++lv +l pEslkekkftsksDvWsfGvllwEiftlgeepypglsneevlekl.kegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 65.7 2.5e-20 Protein tyrosine kinase 191 Cluster-782.348-0R PF00069.22 1 83 166 259 PEVLRNERSNEKCDVYSFGVILWELATLKLPWSGMNPMQV-----------VGAVGFQNRRLDIPKEVDPLVARIIWECWQTDPSLRPSFAQLV PEvl++++ +k+Dv+s Gvil+el t k p+sg + + + +g ++ l+ ++e+++ + +++ ++++ dp+ R+++++l+ PEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeell 35.0 6.1e-11 Protein kinase domain 191 Cluster-782.3496-0F CAMK_OST1L 58 301 1 251 YEIQKDLGSGNFGVAKLVRDKCTGELYAVKYIERG-KKIDEHVQREIMNHRALKHPNIVRFKEVLLTPTHLAIVMEYAAGGELFERICNAGRFSEDEARFFFQQLISGVSYCHSMQICHRDLKLENTLLDGSSAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLSR---KEYDGKIADVWSCGVTLYVMLVGAYPFEDPDDP---RNFKKTINRILSVHYSIPDYVRVSKECKHLLSQIFVADPEK ye+ kdlgsg+fGva+lvrdk t+el+AvK+ierg +k+de+v+rEi+nhr L+Hpnivrfkev+ltpthla+vmEYa+ggel+e+++++gr+sedear++fqQl+sgv+ycH++++++Rdlklen+lLdgs+ap+lkicDFg+skss+ +s+pks+vGtpayiaPevl++ keYdgk+aDvwscGv+Lyvml+gayPfed++d+ +++kkt++ril+v+y+ip++v++s+ec++Lls+i+vadp+k yevvkdlgsgsfGvarlvrdketkelvAvKlierglekvdenvkrEilnhrsLrHpnivrfkevvltpthlalvmEYadggelleyvskkgrlsedearylfqQlvsgvdycHrkgvvnRdlklenllLdgseapllkicDFgfskssledskpksrvGtpayiaPevlaaakakeYdgkkaDvwscGvvLyvmllgayPfedeedkkekkevkktlqrileveykipevvaiseecrdLlskilvadpak 387.5 2e-118 CAMK_OST1L 534 Cluster-782.3496-0F PF00069.22 58 301 1 251 YEIQKDLGSGNFGVAKLVRDKCTGELYAVKYIERGKKID---EHVQREIMNHRALKHPNIVRFKEVLLTPTHLAIVMEYAAGGELFERICNAGRFSEDEARFFFQQLISGVSYCHSMQICHRDLKLENTLLDGSSAprLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLSRKEYdGKIADVWSCGVTLYVMLVGAYPFEDPDDPRNFKKTINR------IL-SVHYSIPDYVRVSKECKHLLSQIFVADPEK ye ++ lG+G+fG+ +++k tg+ +AvK i++ k+ + ++v+rEi ++ lkhpnivr++ev+ ++++l +v+ey+ ggel++++ + g +se+ea+++++q+++g++y+Hs++i+HrDlK eN L+d ++ lKi+DFG +k +s+ +s vgt+ Y+APEvl+++ey +k +DvWs+Gv+ly +l g pf++ ++ +++k +++ il ++ ++p +s+e+k+ll++++ dp+k yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekge..lKitDFGlakelessskltsfvgtreYlAPEvlkeney.skkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkk 223.4 2.2e-68 Protein kinase domain 534 Cluster-782.3496-0F PF07714.14 59 300 2 248 EIQKDLGSGNFGVA---KLV-RDKCTGELYAVKYIERGKKID--EHVQREIMNHRALKHPNIVRFKEVLLTPTHLAIVMEYAAGGELFERICNA---GRFSEDEARFFFQQLISGVSYCHSMQICHRDLKLENTLLDGssAPRLKICDFGYSKSS---VLHSQPKSTVGTPAYIAPEVLSRKEYDGKiADVWSCGVTLYVMLV-GAYPFEDPdDPRNFKKTInrilSVHYSIPDYVRVSKECKHLLSQIFVADPE e++k+lG+G+fG +l +++ + avK ++++++ + e++ +e+ ++lkhpniv++ v + +l iv+ey++gG+L + + + +++ ++ f +q+ +G++y +s+++ Hrdl N Ll+ ki+DfG +++ ++ +++ ++apE+l++k++ k +DvWs Gv+l+ ++ g+ p+++ +++++ +++ + ++ ++ +++e ++l++q + +dpe elgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlse..nkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsk.sDvWsfGvllwEiftlgeepypgl.sneevlekl....kegkrlekpekcpeelyelmkqCweedpe 104.4 4e-32 Protein tyrosine kinase 534 Cluster-782.3497-0F CAMK_OST1L 58 314 1 264 YEIQKDLGSGNFGVAKLVRDKCTGELYAVKYIERG-KKIDEHVQREIMNHRALKHPNIVRFKEVLLTPTHLAIVMEYAAGGELFERICNAGRFSEDEARFFFQQLISGVSYCHSMQICHRDLKLENTLLDGSSAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLSR---KEYDGKIADVWSCGVTLYVMLVGAYPFEDPDDP---RNFKKTINRILSVHYSIPDYVRVSKECKHLLSQIFVADPEKRITIPEIKKHPWF ye+ kdlgsg+fGva+lvrdk t+el+AvK+ierg +k+de+v+rEi+nhr L+Hpnivrfkev+ltpthla+vmEYa+ggel+e+++++gr+sedear++fqQl+sgv+ycH++++++Rdlklen+lLdgs+ap+lkicDFg+skss+ +s+pks+vGtpayiaPevl++ keYdgk+aDvwscGv+Lyvml+gayPfed++d+ +++kkt++ril+v+y+ip++v++s+ec++Lls+i+vadp+kRiti eik+hpWf yevvkdlgsgsfGvarlvrdketkelvAvKlierglekvdenvkrEilnhrsLrHpnivrfkevvltpthlalvmEYadggelleyvskkgrlsedearylfqQlvsgvdycHrkgvvnRdlklenllLdgseapllkicDFgfskssledskpksrvGtpayiaPevlaaakakeYdgkkaDvwscGvvLyvmllgayPfedeedkkekkevkktlqrileveykipevvaiseecrdLlskilvadpakRitieeikehpWf 416.0 4.3e-127 CAMK_OST1L 508 Cluster-782.3497-0F PF00069.22 58 314 1 264 YEIQKDLGSGNFGVAKLVRDKCTGELYAVKYIERGKKID---EHVQREIMNHRALKHPNIVRFKEVLLTPTHLAIVMEYAAGGELFERICNAGRFSEDEARFFFQQLISGVSYCHSMQICHRDLKLENTLLDGSSAprLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLSRKEYdGKIADVWSCGVTLYVMLVGAYPFEDPDDPRNFKKTINR------IL-SVHYSIPDYVRVSKECKHLLSQIFVADPEKRITIPEIKKHPWF ye ++ lG+G+fG+ +++k tg+ +AvK i++ k+ + ++v+rEi ++ lkhpnivr++ev+ ++++l +v+ey+ ggel++++ + g +se+ea+++++q+++g++y+Hs++i+HrDlK eN L+d ++ lKi+DFG +k +s+ +s vgt+ Y+APEvl+++ey +k +DvWs+Gv+ly +l g pf++ ++ +++k +++ il ++ ++p +s+e+k+ll++++ dp+kR+t+ e+++hp++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekge..lKitDFGlakelessskltsfvgtreYlAPEvlkeney.skkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 246.3 2.2e-75 Protein kinase domain 508 Cluster-782.3497-0F PF07714.14 59 310 2 258 EIQKDLGSGNFGVA---KLV-RDKCTGELYAVKYIERGKKID--EHVQREIMNHRALKHPNIVRFKEVLLTPTHLAIVMEYAAGGELFERICNA---GRFSEDEARFFFQQLISGVSYCHSMQICHRDLKLENTLLDGssAPRLKICDFGYSKSS---VLHSQPKSTVGTPAYIAPEVLSRKEYDGKiADVWSCGVTLYVMLV-GAYPFEDPdDPRNfkkTINRIlSVHYSIPDYVRVSKECKHLLSQIFVADPEKRITIPEIKK e++k+lG+G+fG +l +++ + avK ++++++ + e++ +e+ ++lkhpniv++ v + +l iv+ey++gG+L + + + +++ ++ f +q+ +G++y +s+++ Hrdl N Ll+ ki+DfG +++ ++ +++ ++apE+l++k++ k +DvWs Gv+l+ ++ g+ p+++ ++++ +++++ + ++ ++ +++e ++l++q + +dpe+R t+ e+ + elgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlse..nkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsk.sDvWsfGvllwEiftlgeepypgl.snee...vlekl.kegkrlekpekcpeelyelmkqCweedpeeRptfkelve 112.6 1.2e-34 Protein tyrosine kinase 508 Cluster-782.3538-0R CK1_CK1 83 317 1 235 FHLGRKIGSGSFGEIYLGTNIQTNEQVAIKLENVKTKHPQLLYESKLYKLLQGGTGIPNVRWFGVEGDYNVLVMDLLGPSLEDLFNFCSRKLSLKTVLMLADQMINRVEFVHSKSFLHRDIKPDNFLMGLGRRANQVYVIDFGLAKKYKDSSTHQHIPYRENKNLTGTARYASMNTHLGIEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGNKKQKYEKISEKKVSTSIEALCRG f+lgrkigsgsfgeiylgtn+qtne+vaikle+vktkhpqllyeskly++lqggtgipn++wfgvegdynvlv+dllgpsledlfn+csrk+slktvlmladq+inrve+vhsk+flhrdikpdnflmglgr+anqvy+idfglakky+d++t++hipyrenknltgtaryas+nthlgieqsrrddleslgyvl+yflrgslpwqglkag+kkqkyekisekkvstsie+lc++ fklgrkigsgsfgeiylgtnvqtneevaiklesvktkhpqllyesklyrilqggtgipnlkwfgvegdynvlvldllgpsledlfnycsrkfslktvlmladqlinrveyvhskgflhrdikpdnflmglgrkanqvyiidfglakkyrdaktkkhipyrenknltgtaryasvnthlgieqsrrddleslgyvllyflrgslpwqglkagtkkqkyekisekkvstsievlcks 482.1 1.9e-147 CK1_CK1 658 Cluster-782.3538-0R PF00069.22 83 300 1 211 FHLGRKIGSGSFGEIYLGTNIQTNEQVAIKLENVKTKHP----QLLYESKLYKLLQgGTGIPNVRWFGVEGDYNVLVMDLLGP-SLEDLFNfCSRKLSLKTVLMLADQMINRVEFVHSKSFLHRDIKPDNFLMGlgrRANQVYVIDFGLAKKYKDSSThqhipyreNKNLTGTARYASMNTHLGIEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGN-KKQKYE ++ +k+G+GsfG++y +++ +t+++vA+K +++ + ++l E k+ k l+ i ++ + e d+ +lv++++ +l+dl + + +ls +++ +a q+++ +e++Hsk+++HrD+Kp+N+L+ + +++ ++DFGlak+++ ss+ ++ +gt +Y + + e s+ D+ slG +l+ +l g p++g k + ++++++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklk.hpnivrlyevfeekdelylvleyveggeladlls.rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLid...ekgelKitDFGlakelesssk........ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeld 96.5 1.1e-29 Protein kinase domain 658 Cluster-782.3538-0R PF07714.14 84 307 2 224 HLGRKIGSGSFGEIYLGTNI----QTNEQVAIKLENVKTKHP---QLLYESKLYKLLqGGTGIPNVRWFGVEGDYNVLVMDLLG-PSLEDLFNFC--SRKLSLKTVLMLADQMINRVEFVHSKSFLHRDIKPDNFLMGLgrrANQVYVIDFGLAKKYKDSSTHqhipyRENKNLTGTARYASMNTHLGIEQSRRDDLESLGYVLMYFLR-GSLPWQGLkagNKKQKYEKISEKKV +lg+k+G+G+fGe++ gt +++ +va+K + ++++ ++l e k+ k l i ++ + ++++ ++v++++ +L++ + ++kl+lk++l +a q+ + +e+ +sk+++Hrd+ N L+ ++v + DfGLa++ +++++ +++++ + ++ ++ + + + + D s G +l+ + g+ p++gl ++++ +ek++e+k elgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkkl.khpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlse...nkvvkisDfGLardiekddey.....kkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypgl...sneevleklkegkr 57.7 6.9e-18 Protein tyrosine kinase 658 Cluster-782.3544-1F CAMK_CAMKL-CHK1 117 371 1 256 YHLGRLLGQGTFAKVYYGRHLKTGQSVAIKVIDKEKVLNAGLINQTKREISVMGLVKHKNVMQLYEVMATKTKIYFVIEYAKGGELFNKVAK-GKLKEDIARRYFQQLITAVGFCHGRGVYHRDLKPENLLLDENGDLKVSDFGLSALVESKRQDGLLHTTCGTPAYVAPEVIRQKGYDGSKTDIWSCGVILFVLLAGHLPFYDSNLMEMYRKITKAEYKFPCWFSPEVRRLLSRILDPNPSTRLSIAKIMQNSWF y+lGrllG+gtfakv+++r+l+tg+svaikv+dkekvl+a+l++q kreisv+ lv+h+nv++l+ev+atk+kiy+v+ey+kGGelf+k+ak g+lked ar+yfqqli+av +ch rgvyhrdlkpenlllde+g+lkvsdfGlsal e++r+dgllhttcGtPayvaPev+++kgydg+k+d+WscGvilfvllag+lPf d+nl+e+yrki+kae+k+p w+s+e+++l+sr+ldpnp+tr++i++i++++Wf yelGrllGegtfakvklardletgesvaikvldkekvlkaklveqikreisvlklvrhpnvvrllevlatkskiylvleyvkGGelfekiakkgrlkedearkyfqqlisavdychsrgvyhrdlkpenllldekgnlkvsdfGlsalaeqlredgllhttcGtPayvaPevlkkkgydgakadvWscGvilfvllagylPfedenlvelyrkilkaefklpkwlskeakklisrlldpnpetritieeileeeWf 439.0 4e-134 CAMK_CAMKL-CHK1 579 Cluster-782.3544-1F PF00069.22 117 371 1 264 YHLGRLLGQGTFAKVYYGRHLKTGQSVAIKVIDKEKVLNAGLiNQTKREISVMGLVKHKNVMQLYEVMATKTKIYFVIEYAKGGELFNKVA-KGKLKEDIARRYFQQLITAVGFCHGRGVYHRDLKPENLLLDENGDLKVSDFGLSALVESKRQdglLHTTCGTPAYVAPEVIRQKGYdGSKTDIWSCGVILFVLLAGHLPFYDSNLM----EMYRK------I---TKAEYKFPCWFSPEVRRLLSRILDPNPSTRLSIAKIMQNSWF y+ + lG+G+f+kVy +++ +tg+ vA+K+i+kek + +++ rEi+++ +kh+n+++lyev+ +k+++y+v+ey++ggel++ + kg+l+e+ a+++++q+++++ ++H +g+ HrDlKpeN+L+de+g+lK++DFGl++ +es+ + l++ +gt+ Y+APEv+++++y ++k+D+Ws+Gvil+ ll+g+ pf++++ +++++ i tk +++ + +s+e+++ll+++l+ +p++Rl++++++q++++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeney.skkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 247.1 1.3e-75 Protein kinase domain 579 Cluster-782.3544-1F PF07714.14 118 367 2 258 HLGRLLGQGTFAKVYYGRHL----KTGQSVAIKVIDKEKVLNAglINQTKREISVMGLVKHKNVMQLYEVMATKTKIYFVIEYAKGGELFNKVAKG----KLKEDIARRYFQQLITAVGFCHGRGVYHRDLKPENLLLDENGDLKVSDFGLSALVESKRQDGLLHTTCGTPAYVAPEVIRQKGYDgSKTDIWSCGVILFVLLA-GHLPFYDSNLMEMYRKItKAEYK--FPCWFSPEVRRLLSRILDPNPSTRLSIAKIMQ +lg+ lG+G+f++V+ g+ k+ ++va+K++++e+ ++ ++ +e+++m +kh+n+++l+ v+ + ++++v+ey++gG+L + + k kl+ + ++ +q+ ++ + + + + Hrdl N Ll+en k+sDfGL+ +e++ + +++ ++apE++++k + sk+D+Ws Gv+l+ ++ g+ p+ + + +e+++k+ k++++ p ++e+ +l+++ ++ +p+ R +++++++ elgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateee..keefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkft.sksDvWsfGvllwEiftlgeepypglsneevlekl.kegkrlekpekcpeelyelmkqCweedpeeRptfkelve 131.9 1.6e-40 Protein tyrosine kinase 579 Cluster-782.3582-2R RLK-Pelle_LRR-VIII-1 674 937 2 260 SVIGQGGYGKVYKGILADGTLVAIKRAQEGSLQGEKEFLTEIQLLSRLHHRNLVQLMGYCDEEGEQMLIYEFMSNGNLRDHLSVKSKLPLSFAMRVRIALGSSRGILYLHTEANPPIFHRDIKATNILLDLKFIAKVSDFGLSRLAPVPDfegdlPSHVSTVVKGTPGYLDPEYFLTHKLTDKSDVYSLGVVFLELLTGMHPISHGKNIVREVNVAYRTGMIFSVIDERMGSYPSECVEKFVNLALKCCQDETDLRPSMAEVLR +++g+GgyGkvykgiladgtlva+kra+egslqg+kef+tei+lLsr+hh+nlv+L+G+c+++geqmL+ye+++nG+lrd+ls ks+ +l+f++r+rialgs++gilyLh+ea+ppi+hrdik++nilld k+ akv+dfGls+l+p ++ +++vstvvkGt+GyldPey+lt+klt+ksdvys+Gvv+lelltg++pi++gk+ivrev+ a+++g++ +++d++++s+++e++ekf++lalkc++de++ rpsm+ev++ nelgrGgyGkvykgiladgtlvavkraeegslqgakefkteielLsrvhhknlvsLvGfcsdkgeqmLvyeylpnGtlrdalsgksaekldfkrrlrialgsakgilyLheeadppiihrdikssnilldeklnakvadfGlsklvpeee.....kekvstvvkGtlGyldPeyyltqklteksdvysfGvvllelltgkkpiekgkyivrevkkalekgkllelldkaleslsleklekflelalkcvedeaeerpsmsevvk 431.1 1.1e-131 RLK-Pelle_LRR-VIII-1 1082 Cluster-782.3582-2R PF00069.22 671 937 2 260 SETSVIGQGGYGKVYKGI-LADGTLVAIKRAQEGSLQGEKE--FLTEIQLLSRLHHRNLVQLMGYCDEEGEQMLIYEFMSNGNLRDHLSvkSKLPLSFAMRVRIALGSSRGILYLHTEAnppIFHRDIKATNILLDLKFIAKVSDFGLSRLAPVPDFegdlpshvSTVVKGTPGYLDPEYFLTHKLTDKSDVYSLGVVFLELLTGMHPISHGKNIVREVNVAYRTGMIFSVI--DERMGSYPSECVEKFVNLALKCCQDETDLRPSMAEVLR ++ + +G+G++GkVyk++ ++g vA+K+ ++ + + +ke +l+Ei++l +l+h+n+v+l++++ e+ e +l+ e++++g+l d+ls k ls + +ia +g+ ylH + i+HrD+K NiL+d k K++DFGl++ + t + gt+ Yl PE +++ + k+Dv+slGv+++elltg +p s+ k+ + + + ++ +i+ ++ + +se+ e++ +l k+++ + R++++e+l+ ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls..rkgslseeeakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk........ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellq 158.2 1.6e-48 Protein kinase domain 1082 Cluster-782.3582-2R PF07714.14 674 939 5 260 SVIGQGGYGKVYKGILA-----DGTLVAIKRAQEGSLQG-EKEFLTEIQLLSRLHHRNLVQLMGYCDEEGEQMLIYEFMSNGNLRDHLSVK-SKLPLSFAMRVRIALGSSRGILYLHTEAnppIFHRDIKATNILLDLKFIAKVSDFGLSRLAPVPDFEgdlpsHVSTVVKGTPGYLDPEYFLTHKLTDKSDVYSLGVVFLELLT-GMHPishgknivreV------NvayrtgMIFSVIDERMGSYPSECVEKFVNLALKCCQDETDLRPSMAEVLREL + +G+G +G+V++g+l + + va+K +e++ + ++efl+e++++++l+h+n+v+l+g c +e++ +++ e++++G+L+++L k +k +l++ +++al ++G+ yL+ + + Hrd+ a N+Ll+ + ++k+sDfGL+r d ++++ k ++ pE + ++k+t ksDv+s Gv+ E++t g +p + + ++ + +++ + p++c e++ +l +C++ + + Rp+++e++++l kklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLardiekddey.....kkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep..........ypglsnee......vleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 152.2 1e-46 Protein tyrosine kinase 1082 Cluster-782.3583-1R RLK-Pelle_LRR-VIII-1 816 996 85 260 VKSKLPLSFAMRVRIALGSSRGILYLHTEANPPIFHRDIKATNILLDLKFIAKVSDFGLSRLAPVPDfegdlPSHVSTVVKGTPGYLDPEYFLTHKLTDKSDVYSLGVVFLELLTGMHPISHGKNIVREVNVAYRTGMIFSVIDERMGSYPSECVEKFVNLALKCCQDETDLRPSMAEVLR ks+ +l+f++r+rialgs++gilyLh+ea+ppi+hrdik++nilld k+ akv+dfGls+l+p ++ +++vstvvkGt+GyldPey+lt+klt+ksdvys+Gvv+lelltg++pi++gk+ivrev+ a+++g++ +++d++++s+++e++ekf++lalkc++de++ rpsm+ev++ gksaekldfkrrlrialgsakgilyLheeadppiihrdikssnilldeklnakvadfGlsklvpeee.....kekvstvvkGtlGyldPeyyltqklteksdvysfGvvllelltgkkpiekgkyivrevkkalekgkllelldkaleslsleklekflelalkcvedeaeerpsmsevvk 262.4 3.4e-80 RLK-Pelle_LRR-VIII-1 1141 Cluster-782.3583-1R PF00069.22 829 996 102 260 RIALGSSRGILYLHTEAnppIFHRDIKATNILLDLKFIAKVSDFGLSRLAPVPDFegdlpshvSTVVKGTPGYLDPEYFLTHKLTDKSDVYSLGVVFLELLTGMHPISHGKNIVREVNVAYRTGMIFSVI--DERMGSYPSECVEKFVNLALKCCQDETDLRPSMAEVLR +ia +g+ ylH + i+HrD+K NiL+d k K++DFGl++ + t + gt+ Yl PE +++ + k+Dv+slGv+++elltg +p s+ k+ + + + ++ +i+ ++ + +se+ e++ +l k+++ + R++++e+l+ kiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk........ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellq 86.6 1.1e-26 Protein kinase domain 1141 Cluster-782.3583-1R PF07714.14 819 998 98 260 KLPLSFAMRVRIALGSSRGILYLHTEAnppIFHRDIKATNILLDLKFIAKVSDFGLSRLAPVPDFEgdlpsHVSTVVKGTPGYLDPEYFLTHKLTDKSDVYSLGVVFLELLT-GMHPishgknivreV------NvayrtgMIFSVIDERMGSYPSECVEKFVNLALKCCQDETDLRPSMAEVLREL k +l++ +++al ++G+ yL+ + + Hrd+ a N+Ll+ + ++k+sDfGL+r d ++++ k ++ pE + ++k+t ksDv+s Gv+ E++t g +p + + ++ + +++ + p++c e++ +l +C++ + + Rp+++e++++l kekltlkdllsfalqiAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLardiekddey.....kkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep..........ypglsnee......vleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 74.8 4.1e-23 Protein tyrosine kinase 1141 Cluster-782.3583-2R RLK-Pelle_LRR-VIII-1 674 760 2 88 SVIGQGGYGKVYKGILADGTLVAIKRAQEGSLQGEKEFLTEIQLLSRLHHRNLVQLMGYCDEEGEQMLIYEFMSNGNLRDHLSGNEI +++g+GgyGkvykgiladgtlva+kra+egslqg+kef+tei+lLsr+hh+nlv+L+G+c+++geqmL+ye+++nG+lrd+lsg+++ nelgrGgyGkvykgiladgtlvavkraeegslqgakefkteielLsrvhhknlvsLvGfcsdkgeqmLvyeylpnGtlrdalsgksa 150.8 4e-46 RLK-Pelle_LRR-VIII-1 1140 Cluster-782.3583-2R PF07714.14 674 759 5 96 SVIGQGGYGKVYKGILA-----DGTLVAIKRAQEGSLQG-EKEFLTEIQLLSRLHHRNLVQLMGYCDEEGEQMLIYEFMSNGNLRDHLSGNE + +G+G +G+V++g+l + + va+K +e++ + ++efl+e++++++l+h+n+v+l+g c +e++ +++ e++++G+L+++L +e kklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkke 61.3 5.5e-19 Protein tyrosine kinase 1140 Cluster-782.3583-2R PF00069.22 671 758 2 91 SETSVIGQGGYGKVYKGI-LADGTLVAIKRAQEGSLQGEKE--FLTEIQLLSRLHHRNLVQLMGYCDEEGEQMLIYEFMSNGNLRDHLSgN ++ + +G+G++GkVyk++ ++g vA+K+ ++ + + +ke +l+Ei++l +l+h+n+v+l++++ e+ e +l+ e++++g+l d+ls + ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls.r 57.5 8.5e-18 Protein kinase domain 1140 Cluster-782.3617-0R IRE1 957 1107 11 179 IQVREGVYENKLAMIKCIDLDGEvRIHQKELSSLMELEGHENVVKYYGVEWDEESCFIALEMCSLTLHDLF------DDEKNFWNEIKS--------------TWDPADDPRTMLLSLIKDIIMGLEYLHSHDLIHRGLNPSNIMIKKECgKFRAKLSNMGSSKRLGGASS v eGvye++ +k+++ + + +ke++ l+ + h n+v+yyg+e de+ +i+le c+l+l+dl +++ +++k+ w+ p ++ll l++di+ Gl +lh+ +++hr l+P n++i k+ ++akls+mg skrl+ s tvvfeGvyegrevavkrllrsht.dkavkeiknliasdehsnivryygleqdedfvyislercalslddlikaslkvlekdddsedvkalklddlekngkeiklwkenGkpsplllklmrdivaGlvhlhelgivhrdlkPqnvliskdr.tlsaklsdmglskrlaedvs 84.6 5.4e-26 IRE1 1123 Cluster-782.3617-0R PF00069.22 954 1107 10 153 GKSIQVREGV--YENKLAMIKCIDLDGEVRIHQ----KELSSLMELEgHENVVKYYGVEWDEESCFIALEMCSLT-LHDLFDDEKNFWNEikstwdpaddprtMLLSLIKDIIMGLEYLHSHDLIHRGLNPSNIMIKkECGKfrAKLSNMGSSKRLGGASS G++ +V ++v ++k +K+i+ + + ++ +E++ l +l+ h+n+v++y+v ++++ ++ le+++ + l+dl +++++ +e + +++k i+ gleylHs+ +iHr l p+Ni+i+ e g+ K++ G +k+l s+ GsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklk.hpnivrlyevfeekdelylvleyveggeladllsrkgslsee.............eakkiakqilegleylHskgiiHrDlKpeNiLid.ekge..lKitDFGlakelesssk 56.2 2.1e-17 Protein kinase domain 1123 Cluster-782.3617-0R PF07714.14 980 1101 45 153 VRIHQKELSSLMELeGHENVVKYYGVEWDEESCFIALEMCSL-TLHDLFDDEknfwneikstWDPADDPRTMLLSLIKDIIMGLEYLHSHDLIHRGLNPSNIMIKKecgKFRAKLSNMGSSKR + +e++ +++l h+n+vk++gv +ee+ +i +e+++ +L++ ++ + + + lls++++i G+eyL+s++l+Hr l N+++++ + +k+s G +++ keefleeakimkkl.khpnivkllgvctkeepllivteyvegGdLlkfLrkk..........eekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlse...nkvvkisDfGLard 39.5 2.4e-12 Protein tyrosine kinase 1123 Cluster-782.3618-2R IRE1 8 99 192 281 KWKAPEQKENDQKVgRYVDLYSLGYIIHFCLTGGKHPQDVGPTSNLEKcPICELLFMLVEDFPEAYDIVSQLMSPQKNKRPSAKQVLKHPFF w+aPeq +++++ r vdl+slG ++++++tggkhP + + + ++lved+pea+++++ql++++ ++rPsak+vl+hP+f GwqaPeqlkegrqt.ravdlfslGcllfyaitggkhPfGeeyerdvni.vnnkkdlflvedlpeavhlikqllnydPdlrPsakdvllhPlf 75.2 3.8e-23 IRE1 326 Cluster-782.3618-2R PF00069.22 8 99 162 264 KWKAPEQKeNDQKVGRYVDLYSLGYIIHFCLTGGKHPQDVGPTS----NLEKcpiCELLFMLV----------E-DFPEAYDIVSQLMSPQKNKRPSAKQVLKHPFF ++ APE +++++++ vD++slG i+ ltg ++ ++ +l++ +e +++++ + +ea d++++l++ +++kR++a+++l+hp++ eYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldq...lekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 28.5 6.1e-09 Protein kinase domain 326 Cluster-782.3774-0F RLK-Pelle_LRR-II 200 287 1 88 KNILGKGGFGIVYKGCLQDGTVVAVKRLKDGNAIGGEIQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGKK knilGkGgfg vykG+l+dgt+vavkrlk+ ++ gge+qfqteve+islavhrnllrl+Gfc+t+ erllvyp+m+ngsvasrl+ +k knilGkGgfgkvykGrladgtlvavkrlkeeesaggelqfqtevelislavhrnllrliGfcttsterllvypymengsvasrlrelk 146.9 5.2e-45 RLK-Pelle_LRR-II 1142 Cluster-782.3774-0F PF00069.22 198 296 2 102 SSKNILGKGGFGIVYKGC-LQDGTVVAVKRLKDGNAIGGE-IQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGKKIFQVTQVTR + ++ lG+G+fG Vyk++ ++g vAvK++k +a + ++++E++++ h+n++rly+++ ++ e++lv ++++g++a++l+ k++++ +++ + ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakk 46.3 2.2e-14 Protein kinase domain 1142 Cluster-782.3774-0F PF07714.14 200 286 4 95 KNILGKGGFGIVYKGCLQ-----DGTVVAVKRLKDGNAIGGEIQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGK ++ lG+G fG V++g l+ + + vavK lk+++ + +f +e+++++ h+n+++l+g+c+ + l+v ++++G++ + L+ k gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk 43.7 1.3e-13 Protein tyrosine kinase 1142 Cluster-782.3774-2F RLK-Pelle_LRR-II 315 448 90 224 AKPPLDWGTRKRIALGAARGLLYLHEQCDPKIIHRDVKAANILLDDYCEAVVGDFGLAKLLDHHDSHITTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGQRALEFGKGANQKGAML-DWVSTTRNQ +kp+ldw trkrialGaarGl ylheqcdpkiihrdvkaanilld+++eavvgdfglaklld++dsh+ttavrGtvGhiapeylstG+ssektdvfG+GilllelitGqrale+++ a++++++l dwv + +++ gkpaldwetrkrialGaarGlsylheqcdpkiihrdvkaanilldeefeavvgdfglaklldkkdshvttavrGtvGhiapeylstGkssektdvfGyGilllelitGqralelsrlaededvllldwvkklkke 243.2 2.2e-74 RLK-Pelle_LRR-II 1142 Cluster-782.3774-2F PF00069.22 323 439 99 210 TRKRIALGAARGLLYLHEQCdpkIIHRDVKAANILLDDYCEAVVGDFGLAKLLDHHDShiTTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGQRALEFGKGANQKGAML + k+ia ++gl ylH+++ iiHrD+K +NiL+d+ e ++DFGlak l+++ + +t + gt +APE l++ + s+k+Dv++ G++l+el+tg+ ++ kg +++ ++l eakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekel 80.8 6.9e-25 Protein kinase domain 1142 Cluster-782.3774-2F PF07714.14 318 424 100 205 PLDWGTRKRIALGAARGLLYLHEQcdpKIIHRDVKAANILLDDYCEAVVGDFGLAKLL-DHHDSHITTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELIT-GQR +l+ + ++al A+G+ yL+++ k++Hrd+ a N+Ll++ + ++DfGLa+ + ++++ + ++ + v +apE l++++ ++k+Dv+ fG+ll E++t g++ kltlkdllsfalqiAkGmeyLesk...klvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgee 67.3 8.3e-21 Protein tyrosine kinase 1142 Cluster-782.3796-0R AGC_RSK-2 254 356 1 103 RLLKRLGCGDIGSVYLAELSGTKCHFAMKVMDKASLAGRKKLLRAQTEREILQSLDHPFLPSLYTHFETEKFSCLVMEFCPGGDLHSLRQRQPGKYFSEQAVK +llk+lG+Gdigsvyl+el+gt+++fa+kv+dk++la rkkl ra++ereil++ldhPflp+ly++fetekf+clv+efcpggdLh+lr+rqp k fse+av+ kllkklGsGdigsvylvelrgtealfalkvldkealakrkklkraeaereilelldhPflptlyasfetekfvclvvefcpggdLhvlrerqpkkvfseeavr 143.6 5.9e-44 AGC_RSK-2 925 Cluster-782.3796-0R PF00069.22 254 356 2 101 RLLKRLGCGDIGSVYLAELSGTKCHFAMKVMDKASLAGRKKlLRAQTEREILQSLDHPFLPSLYTHFETEKFSCLVMEFCPGGDLHSLRQrqPGKYFSEQAVK + l++lG G+ G+Vy a + t++++A+K+++k + +k+ ++++E +il++l+hp++ ly fe+++ +lv+e+++gg+l++l + + +se+ +k ekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls..rkgslseeeak 54.5 7.1e-17 Protein kinase domain 925 Cluster-782.3796-0R PF07714.14 255 344 3 94 LLKRLGCGDIGSVYLAELS----GTKCHFAMKVMDKASLAgrKKLLRAQTEREILQSLDHPFLPSLYTHFETEKFSCLVMEFCPGGDLHSLRQR l k+lG G G+V+ ++l+ ++++ a+K++++ + + ++ + +e +i+++l+hp + +l+ e+ ++v+e+++gGdL++ ++ lgkklGeGafGeVvegtlkgekekkevkvavKtlkeeate..eekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrk 34.1 1.1e-10 Protein tyrosine kinase 925 Cluster-782.3796-2R AGC_RSK-2 497 734 102 258 FRFYVAEVLLALEYLHMLGIVYRDLKPENVLVRDDGHIMLSDFDLSLRCVVSptlvktssltsepprknsaycaqpaciepsciqpscvvptscfsprlfsrkskkdgkpkpkieignqvsplpelmaeptnaRSMSFVGTHEYLAPEIIKGEGHGSAVDWWTFGIFLYELLFGKTPFKGSGNRATLFNVVGQPLRFPESPVVSFAARDLIRGLLVKEPQNRLAYKRGATEIKQHPFF rfy+aev+laleylh+lgivyrdLkPenvlvr+dGhiml+DfDLsl++ + rs+sfvGt+eylaPeiikgeghgsavdWW++Gi+lyell+gktPfkg+ +++tl+nv+ ++l+fpe++ vs++ardlir+ll+k+p++rl++krga+eik+hpff vrfyaaevvlaleylhalgivyrdLkPenvlvredGhimltDfDLslkasak.................................................................................rsnsfvGteeylaPeiikgeghgsavdWWalGillyellygktPfkgknreetlanvlkkelefpeeaavsleardlirkllekdpkkrlgskrgaaeikkhpff 272.7 2.4e-83 AGC_RSK-2 925 Cluster-782.3796-2R PF00069.22 497 549 100 152 FRFYVAEVLLALEYLHMLGIVYRDLKPENVLVRDDGHIMLSDFDLSLRCVVSP +++++++l +leylH gi++rDlKpeN+L+ ++g+++++DF+l+ + s akkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesss 51.6 5.3e-16 Protein kinase domain 925 Cluster-782.3796-2R PF00069.22 631 734 154 264 SMSFVGTHEYLAPEIIKGEGHGSAVDWWTFGIFLYELLFGKTPFKGSGNRATLFNVVGQ-----------PLRFPESPVVSFAARDLIRGLLVKEPQNRLAykrgATEIKQHPFF +sfvgt+eYlAPE++k+++++++vD+W+ G+ lyell+gk+pf+g+ ++ + + + q + +pe +s a+dl++ ll k+p++Rl a+e++qhp++ ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRlt....aeellqhpyl 72.9 1.8e-22 Protein kinase domain 925 Cluster-782.3796-2R PF07714.14 502 545 111 154 AEVLLALEYLHMLGIVYRDLKPENVLVRDDGHIMLSDFDLSLRC +++ ++eyL+ +v rdl NvL++++ ++ +sDf L+ + lqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardi 21.4 8.6e-07 Protein tyrosine kinase 925 Cluster-782.3796-2R PF07714.14 637 721 169 253 THEYLAPEIIKGEGHGSAVDWWTFGIFLYELLF-GKTPFKGSgNRATLFNVVGQPLRFPESPVVSFAARDLIRGLLVKEPQNRLAY +++apE++k + s+ D W fG+ l+E++ g++p++g + +++++ + + r ++ ++ + +l++ + ++p++R + pvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypgl.sneevleklkegkrlekpekcpeelyelmkqCweedpeeRptf 26.4 2.6e-08 Protein tyrosine kinase 925 Cluster-782.3797-0R AGC_RSK-2 254 356 1 103 RLLKRLGCGDIGSVYLAELSGTKCHFAMKVMDKASLAGRKKLLRAQTEREILQSLDHPFLPSLYTHFETEKFSCLVMEFCPGGDLHSLRQRQPGKYFSEQAVK +llk+lG+Gdigsvyl+el+gt+++fa+kv+dk++la rkkl ra++ereil++ldhPflp+ly++fetekf+clv+efcpggdLh+lr+rqp k fse+av+ kllkklGsGdigsvylvelrgtealfalkvldkealakrkklkraeaereilelldhPflptlyasfetekfvclvvefcpggdLhvlrerqpkkvfseeavr 144.0 4.5e-44 AGC_RSK-2 893 Cluster-782.3797-0R PF00069.22 254 356 2 101 RLLKRLGCGDIGSVYLAELSGTKCHFAMKVMDKASLAGRKKlLRAQTEREILQSLDHPFLPSLYTHFETEKFSCLVMEFCPGGDLHSLRQrqPGKYFSEQAVK + l++lG G+ G+Vy a + t++++A+K+++k + +k+ ++++E +il++l+hp++ ly fe+++ +lv+e+++gg+l++l + + +se+ +k ekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls..rkgslseeeak 55.4 3.7e-17 Protein kinase domain 893 Cluster-782.3797-0R PF07714.14 255 345 3 95 LLKRLGCGDIGSVYLAELS----GTKCHFAMKVMDKASLAgrKKLLRAQTEREILQSLDHPFLPSLYTHFETEKFSCLVMEFCPGGDLHSLRQRQ l k+lG G G+V+ ++l+ ++++ a+K++++ + + ++ + +e +i+++l+hp + +l+ e+ ++v+e+++gGdL++ +++ lgkklGeGafGeVvegtlkgekekkevkvavKtlkeeate..eekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk 34.7 7.2e-11 Protein tyrosine kinase 893 Cluster-782.3797-1R AGC_RSK-2 465 702 102 258 FRFYVAEVLLALEYLHMLGIVYRDLKPENVLVRDDGHIMLSDFDLSLRCVVSptlvktssltsepprknsaycaqpaciepsciqpscvvptscfsprlfsrkskkdgkpkpkieignqvsplpelmaeptnaRSMSFVGTHEYLAPEIIKGEGHGSAVDWWTFGIFLYELLFGKTPFKGSGNRATLFNVVGQPLRFPESPVVSFAARDLIRGLLVKEPQNRLAYKRGATEIKQHPFF rfy+aev+laleylh+lgivyrdLkPenvlvr+dGhiml+DfDLsl++ + rs+sfvGt+eylaPeiikgeghgsavdWW++Gi+lyell+gktPfkg+ +++tl+nv+ ++l+fpe++ vs++ardlir+ll+k+p++rl++krga+eik+hpff vrfyaaevvlaleylhalgivyrdLkPenvlvredGhimltDfDLslkasak.................................................................................rsnsfvGteeylaPeiikgeghgsavdWWalGillyellygktPfkgknreetlanvlkkelefpeeaavsleardlirkllekdpkkrlgskrgaaeikkhpff 272.8 2.2e-83 AGC_RSK-2 893 Cluster-782.3797-1R PF00069.22 465 517 100 152 FRFYVAEVLLALEYLHMLGIVYRDLKPENVLVRDDGHIMLSDFDLSLRCVVSP +++++++l +leylH gi++rDlKpeN+L+ ++g+++++DF+l+ + s akkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesss 51.7 5e-16 Protein kinase domain 893 Cluster-782.3797-1R PF00069.22 599 702 154 264 SMSFVGTHEYLAPEIIKGEGHGSAVDWWTFGIFLYELLFGKTPFKGSGNRATLFNVVGQ-----------PLRFPESPVVSFAARDLIRGLLVKEPQNRLAykrgATEIKQHPFF +sfvgt+eYlAPE++k+++++++vD+W+ G+ lyell+gk+pf+g+ ++ + + + q + +pe +s a+dl++ ll k+p++Rl a+e++qhp++ ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRlt....aeellqhpyl 73.0 1.6e-22 Protein kinase domain 893 Cluster-782.3797-1R PF07714.14 470 513 111 154 AEVLLALEYLHMLGIVYRDLKPENVLVRDDGHIMLSDFDLSLRC +++ ++eyL+ +v rdl NvL++++ ++ +sDf L+ + lqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardi 21.4 8.2e-07 Protein tyrosine kinase 893 Cluster-782.3797-1R PF07714.14 605 689 169 253 THEYLAPEIIKGEGHGSAVDWWTFGIFLYELLF-GKTPFKGSgNRATLFNVVGQPLRFPESPVVSFAARDLIRGLLVKEPQNRLAY +++apE++k + s+ D W fG+ l+E++ g++p++g + +++++ + + r ++ ++ + +l++ + ++p++R + pvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypgl.sneevleklkegkrlekpekcpeelyelmkqCweedpeeRptf 26.4 2.5e-08 Protein tyrosine kinase 893 Cluster-782.3828-0F RLK-Pelle_LRR-III 395 657 1 264 EVLGKGTFGTTYKAALEDATVVAVKRLREV-SIGRKDFEQQMEVVGNIRHENVAPLRSYYYSKDEKLMVYDFYNQGSVSVLLHAKRGEDRIPLDWESRLRIAIGAARGIAYIHLQNSGKLVHGNIKASNIFLNSQKYGCISDLGLATLMSPIAPPVMRTAGYRAPEVTDTRKVSQPSDVYSYGVLLLELLTGKSPVHSTGGDEVIHLVRWVHSVVREEWTGEVFDAELLKYPNIEEEMVVMLQIGMSCVARMPEHRPKMVDVVK evLGkg++gt+Yka+le+ +vvaVkrl+ev + +rk+fe+++e +g++rH+nv+plr+yyyskdEkL+vyd++++gs++ llh++r+++r pldwe+rl+ia+g+arG+ay+h ++++klvHgn+k+sni+l+++ ++isd+gLa+l+++ a r++gyraPE++++rk+sq sDVYs+Gv+lLElltgksp++++ +e ++l++wv+svv+ee+t evfd+el+k+ ++eee+v +lq++++Cva+ pe+Rpkm +vvk evLGkgsvgtvYkavleegavvaVkrlkevaaaerkefeeevealgklrHpnvvplrayyyskdEkLlvydyvpngsLasllhgsrsssrtpldwearlkialgvarGlaylheesekklvHgnlkssniLldadlearisdygLarllasaaaasaralgyraPElakarkasqksDVYsfGvvlLElltgkspskasseeeevdlpkwvrsvveeektaevfdvelvkekeaeeelvellqvalaCvaaspekRpkmkevvk 360.8 2.8e-110 RLK-Pelle_LRR-III 771 Cluster-782.3828-0F PF00069.22 395 657 5 260 EVLGKGTFGTTYKAA-LEDATVVAVKRLREVSIGRKD---FEQQMEVVGNIRHENVAPLRSYYYSKDEKLMVYDFYNQGSVSVLLHakrgeDRIPLDWESRLRIAIGAARGIAYIHLQNsgkLVHGNIKASNIFLNSQKYGCISDLGLATLMSPIA--PPVMRTAGYRAPEVTDTRKVSQPSDVYSYGVLLLELLTGKSPVHSTGGDE-VIHLVRWVHSVV---ReewtgevfdAELLKYPNIEEEMVVMLQIGMSCVARMPEHRPKMVDVVK e lG+G+fG+ yka e+ vAvK++++ ++ k+ + + ++++ +++h+n+ l +++++kde ++v ++ ++g++ ll+ ++ l+ e +ia ++g++y+H ++ ++H +K +Ni++++++ i+D+Gla+ ++ ++ t Y+APEv +++++s+++Dv+s+Gv+l+elltgk p +++ g+e v + ++ +++++ + + +k+p+ +e ++++ +++++ p++R+ + ++++ eklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls.....rkgslseeeakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.........etkeklpeaselseeakdllkkllkkdpkkRltaeellq 119.9 8e-37 Protein kinase domain 771 Cluster-782.3828-0F PF07714.14 395 657 5 258 EVLGKGTFGTTYKAALE-----DATVVAVKRLREVSIGR--KDFEQQMEVVGNIRHENVAPLRSYYYSKDEKLMVYDFYNQGSVSVLLHAKrgEDRIPLDWESRLRIAIGAARGIAYIHLQNsgkLVHGNIKASNIFLNSQKYGCISDLGLATLM-----SPIAPPVMRTAGYRAPEVTDTRKVSQPSDVYSYGVLLLELLT-GKSPvhstggdevihlvrwVHSVVREEWTGEVFDAELLKYPNIEEEMVVmlQIGMSCVARMPEHRPKMVDVVK + lG+G+fG+ +++ l+ + + vavK l+e + + ++f +++++ +++h+n+ l ++++++ l+v ++ ++G+++ L++k e++ +l+ ++ l++a+ A+G++y++ ++ lvH ++ a N++l+++k isD GLa + + apE+ +++k+++ sDv+s+Gvll E++t g++p ++++ ee + + + + l+ p+ +e + ++ ++C+++ pe+Rp++ ++v+ kklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk..eekekltlkdllsfalqiAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep...............ypglsneevleklkegkrlekpekcpeely..elmkqCweedpeeRptfkelve 114.1 4.3e-35 Protein tyrosine kinase 771 Cluster-782.3979-2F CAMK_CDPK 124 382 1 259 YKLGKELGKGQFGVTYLCTEIATGQTYACKSILKRKLVSKNDKEDMKREVHIMQHLSGQANIVEFKGAYEDRQSVHVLMELCAGGELFDRIIAQGHYSERAAAELCRQIVNVVHHCHFMGVMHRDLKPENFLLASKDEKAMLKATDFGLSVFIEEGKIYRDVVGSAYYVAPEVLRRSYGKEIDIWSAGVILYILLSGVPPFWAETEKGIFDAILKEEIDFESQPWPLISDSAKDLVRQMLTKDPKKRITSSKVLEHPWI y+lgkelG+G+fGv++l+te atg+++A+Ksi krkl++++d ed++rev+i++hlsg+ n+v++kgayed++svh++melc+ggel+dri+a+g+yseraaa+++rqi++vv++cH +gv+hrDlKPeNfll+sk+e+a+lka+DFGlsvf++eg+ ++d+vGs+yyvaPEvl+rsygke+d+WsaGvilyill+gvppfwaete++if+a+lk+e+df+s+pw+ +s++akdlvr++L+kdpkkR+t ++vLehpW+ yelgkelGrGefGvvrlatekatgeevAvKsiskrklskaedvedvrrevkilkhlsghknvvqlkgayedkdsvhlvmelceggelldrilargkyseraaakvvrqilevvaacHskgvvhrDlKPeNflltskeedaplkaiDFGlsvfvkegerledivGspyyvaPEvlkrsygkeadvWsaGvilyillcgvppfwaeteeeifkavlkaeldfksepwksvseeakdlvrrlLekdpkkRltaeqvLehpWl 415.1 8.9e-127 CAMK_CDPK 689 Cluster-782.3979-2F PF00069.22 124 382 1 264 YKLGKELGKGQFGVTYLCTEIATGQTYACKSILKRKLVSKNDkEDMKREVHIMQHLSgQANIVEFKGAYEDRQSVHVLMELCAGGELFDRIIAQGHYSERAAAELCRQIVNVVHHCHFMGVMHRDLKPENFLLASKDEkamLKATDFGLSVFIEEGKIYRDVVGSAYYVAPEVL-RRSYGKEIDIWSAGVILYILLSGVPPFWAETEKGIFDAILKE---------EIDFESQPWPLISDSAKDLVRQMLTKDPKKRITSSKVLEHPWI y+ ++lG+G+fG+ y ++e +tg+++A+K i k+k +k++ +++ rE++i+++l+ niv++++++e+ +++++++e++ ggel+d++ ++g++se+ a ++++qi++ ++++H +g++HrDlKpeN+L+ +k+e lK tDFGl+ +e+++ ++++vg+ +Y+APEvl +++y+k++D+Ws+Gvily ll+g ppf++e++k + ++l++ e +++++ + +s++akdl++++l+kdpkkR+t +++l+hp++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklk.hpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekge...lKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 245.4 4.3e-75 Protein kinase domain 689 Cluster-782.3979-2F PF07714.14 125 378 2 258 KLGKELGKGQFGVTYLCTEIATGQTYACKSILKRK--LVSKNDKEDMKREVHIMQHLsGQANIVEFKGAYEDRQSVHVLMELCAGGELFDRIIAQ---GHYSERAAAELCRQIVNVVHHCHFMGVMHRDLKPENFLLASkdeKAMLKATDFGLSVFIEEGKIYR---DVVGSAYYVAPEVLRR-SYGKEIDIWSAGVILYILLS-GVPPFWAETEKGIFDAIlKEEIDfeSQPWPLISDSAKDLVRQMLTKDPKKRITSSKVLE +lgk+lG+G+fG + +t + ++ +k ++K ++++ke++ +e++im++l + niv++ g++ +++++ +++e+++gG+L + + ++ + + + ++++qi + +++ + + ++Hrdl N Ll++ + + k +DfGL+ ie+ + y+ + + ++apE+l++ ++ ++ D+Ws Gv+l+ +++ g p++ +++ +++++ ke+ + ++++ ++l++q +++dp++R t ++++e elgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkkl.khpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlse...nkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevlekl.kegkr..lekpekcpeelyelmkqCweedpeeRptfkelve 102.5 1.5e-31 Protein tyrosine kinase 689 Cluster-782.3998-2R CMGC_MAPK 65 152 18 105 GLNSETNGYVAIKKIANDFHNKTDAKRSLREIKFLRHMDHENVVALKDIISPPQRESFNDVYIAYELMDTDLHQIIRSNQALSEEHWQ +++et+ vaikki++ f+n++dakr lreik+lr+++hen+v+lkd+++p+++e+f+Dvyi++elmdtdlhq+i+sn++l+eeh q avdtetgekvaikkiedvfenlidakrvlreikllrrlehenivelkdvlkpaekeefkDvyivlelmdtdlhqviksndelteehvq 117.4 5.5e-36 CMGC_MAPK 244 Cluster-782.3998-2R PF00069.22 64 151 17 100 SGLNSETNGYVAIKKIANDFHNKTDAKRSLREIKFLRHMDHENVVALKDIISPpqresFNDVYIAYELMDTD-LHQIIRSNQALSEEHW +++++et+ vA+Kki ++ +k++ k+ lrEik+l++++h+n+v l+++++ +++y+ e+++++ l+++++ +++lsee+ kaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee.....kdelylvleyveggeladllsrkgslseeea 44.8 6.5e-14 Protein kinase domain 244 Cluster-782.3998-2R PF07714.14 66 151 23 96 LNSETNGYVAIKKIANDfHNKTDAKRSLREIKFLRHMDHENVVALKDIISppQRESfndVYIAYELMDT-DLHQIIRSNqalseehW +++++ va+K++ ++ +++++ ++ l+e+k++++++h+n+v+l +++ ++e+ ++i e+++ dL++ +r++ ekekkevkvavKtlkee.ateeekeefleeakimkklkhpnivkllgvct..keep...llivteyvegGdLlkfLrkk.......e 27.2 1.4e-08 Protein tyrosine kinase 244 Cluster-782.3999-2R CMGC_MAPK 1 248 8 257 GKGTYHIVCSALNSETNEYVAIKKIANAFDNRIDAKRTLREIKLLRHMDHENVVAIRDIIPPPQRESFNDVYIAYELMDTDLHQIIRSNQPLSEEHCQYFLYQILRGLKYIHSASVLHRDLKPSNLLLNANCDLKICDFGLARV-TSETDFMTEYVVTRWYRAPELLLNSSDYTTAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLVMELIGTPLEAELGFL-NENAKRYIRQLPPYRRQSFTEKFPHV GkG+y +vcsa+++et+e vaikki+++f+n+idakr+lreikllr+++hen+v+++d++ p+++e+f+Dvyi++elmdtdlhq+i+sn+ l+eeh+qy+lyq+lrglky+hsa+vlhrDlkp+nlllnanc+lkicDfGlar+ +setd++teyvvtrwyraPelll+ss+Yt+aiDvWsvGCif+el+ rkplfpg+d+v+ql+l++eliGtp e++l ++ +e+a+ry+++lp ++++s+++kfp+v GkGsygvvcsavdtetgekvaikkiedvfenlidakrvlreikllrrlehenivelkdvlkpaekeefkDvyivlelmdtdlhqviksndelteehvqyllyqllrglkylhsanvlhrDlkpknlllnancklkicDfGlarsassetdllteyvvtrwyraPelllssskYtsaiDvWsvGCifaelltrkplfpgkdvvdqlkliteliGtpseedlesvrsekarrylkklpkkakkslkkkfpkv 412.8 5.5e-126 CMGC_MAPK 248 Cluster-782.3999-2R PF00069.22 1 210 8 219 GKGTYHIVCSALNSETNEYVAIKKIANAFDNRIDAKRTLREIKLLRHMDHENVVAIRDIIPPpqresFNDVYIAYELMDTD-LHQIIRSNQPLSEEHCQYFLYQILRGLKYIHSASVLHRDLKPSNLLLNANCDLKICDFGLARVTSETDFMTEYVVTRWYRAPELLlNSSDYTTAIDVWSVGCIFMELMDRKPLFPGRD-------HVHQLRLVMEL G+G++ V +a+++et++ vA+Kki + ++ + k++lrEik+l++++h+n+v + +++ +++y+ e+++++ l+++++ ++ lsee+++ +++qil+gl+y+Hs++++HrDlKp+N+L++ + +lKi+DFGla+ +++ +t++v+tr+Y+APE+l ++++y++++DvWs+G+i++el+ +kp+f+g++ +++ql ++++ GeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee.....kdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtreYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilki 209.9 2.8e-64 Protein kinase domain 248 Cluster-782.3999-2R PF07714.14 1 190 8 201 GKGTYHIVCSALNS----ETNEYVAIKKIANAFDNRiDAKRTLREIKLLRHMDHENVVAIRDIIPppQRESfndVYIAYELMDT-DLHQIIRSN---QPLSEEHCQYFLYQILRGLKYIHSASVLHRDLKPSNLLLNANCDLKICDFGLARVT----SETDFMTEYVVTRWYrAPELLLNSSdYTTAIDVWSVGCIFMELMD G+G++ V+++ + +++ va+K++ + +++ + ++ l+e+k++++++h+n+v++ ++ ++e+ ++i e+++ dL++ +r++ ++l+ ++ f +qi +G++y++s +++Hrdl N Ll+ n ki+DfGLar + + ++ ++ + +W+ apE l +++ +t++ DvWs G + +E++ GeGafGeVvegtlkgekekkevkvavKtlkeeatee.ekeefleeakimkklkhpnivkllgvct..keep...llivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWm.apEslkekk.ftsksDvWsfGvllwEift 110.1 7.3e-34 Protein tyrosine kinase 248 Cluster-782.4010-2R CAMK_CAMKL-CHK1 56 311 1 256 YEFGRTLGEGNFGKVKYAVNVDSGQPFAIKILEKNRIIDLKIADQIKREIGTLKLIKHPNVVRLHEVLASKTKIYMVLEYVNGGELFDRISSKGKLSEAEGRKFFQQLVDGVSYCHNRGVFHRDLKLENVLIDASGNIKITDFGLSALPQHFWADGLLHTTCGSPNYVAPEILSNRGYNGATSDTWSCGVILYVILTGYLPFDDRNLAVLYQKIFKGDAQMPKWLSPGARNLIKRILDPNPCTRMTMAEIKEDDWF ye+Gr+lGeg+f+kvk+a ++++g+ +aik+l+k+++++ k+++qikrei +lkl++hpnvvrl+evla+k+kiy+vleyv+GGelf++i++kg+l+e e+rk+fqql+++v+ych+rgv+hrdlk en+l+d++gn+k++dfGlsal+++ +dgllhttcG+P+yvaPe+l+++gy+ga++d WscGvil+v+l+gylPf+d+nl+ ly+ki+k++ ++pkwls++a++li+r+ldpnp tr+t++ei+e++Wf yelGrllGegtfakvklardletgesvaikvldkekvlkaklveqikreisvlklvrhpnvvrllevlatkskiylvleyvkGGelfekiakkgrlkedearkyfqqlisavdychsrgvyhrdlkpenllldekgnlkvsdfGlsalaeqlredgllhttcGtPayvaPevlkkkgydgakadvWscGvilfvllagylPfedenlvelyrkilkaefklpkwlskeakklisrlldpnpetritieeileeeWf 409.6 3.7e-125 CAMK_CAMKL-CHK1 861 Cluster-782.4010-2R PF00069.22 56 311 1 264 YEFGRTLGEGNFGKVKYAVNVDSGQPFAIKILEKNRIIDLKIaDQIKREIGTLKLIKHPNVVRLHEVLASKTKIYMVLEYVNGGELFDRISSKGKLSEAEGRKFFQQLVDGVSYCHNRGVFHRDLKLENVLIDASGNIKITDFGLSALPQHFWAdglLHTTCGSPNYVAPEILSNRGYnGATSDTWSCGVILYVILTGYLPFDDRNLA-----VLYQ-----KIF---KGDAQMPKWLSPGARNLIKRILDPNPCTRMTMAEIKEDDWF ye ++lGeG+fGkV av+ ++g+ +A+K+++k+++ + k +++ rEi lk +khpn+vrl ev+ +k+++y+vleyv+ggel+d++s kg+lse+e +k+++q++ g++y+H++g++HrDlK eN+Lid +g++KitDFGl++ ++ l++ +g+++Y+APE+l++++y ++++D Ws+Gvily +ltg pf +++ l q ki+ k + + ++ ls+ a++l+k++l+ +p +R+t++e+++++++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeney.skkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 241.4 6.7e-74 Protein kinase domain 861 Cluster-782.4010-2R PF07714.14 57 307 2 258 EFGRTLGEGNFGKVKYAVNV----DSGQPFAIKILEKNRIIDLkiADQIKREIGTLKLIKHPNVVRLHEVLASKTKIYMVLEYVNGGELFDRISSK---GKLSEAEGRKFFQQLVDGVSYCHNRGVFHRDLKLENVLIDASGNIKITDFGLSALPQHFWADGLLHTTCGSPNYVAPEILSNRGYNgATSDTWSCGVILYVILT-GYLPFDDRNLAVLYQKIFKGD-AQMPKWLSPGARNLIKRILDPNPCTRMTMAEIKE e+g++lGeG+fG+V + ++ + a+K+l+++ + +++ +e+ ++k +khpn+v+l+ v ++ ++++v+eyv+gG+L + + +k kl+ + +f +q+ +G++y +++ + Hrdl NvL++ + +ki+DfGL+ ++ +++ + +++apE+l+++ ++ sD Ws Gv+l+ i+t g p+ + + + +++k+ +g ++p+ ++ +l+k+ ++ +p R t++e+ e elgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateee..keefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkft.sksDvWsfGvllwEiftlgeepypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelve 134.4 2.7e-41 Protein tyrosine kinase 861 Cluster-782.4062-2F CMGC_GSK 82 364 1 283 AERVVGTGSFGIVYQAKCLETGETVAIKKVLQDRRYKNRELQLMRSMDHPNVISLKHCFFSTTSRDEVFLNLVMDFVPENMYNVLKHFSDSNQRMPLIYVKLYTYQLFRGLAYLHTVAGVCHRDIKPQNVLVDPLTHQVKICDFGSAKVLVPGEANISYICSRYYRAPELIFGAAEYRTSVDIWSAGCVLAELLLGQPLFPGENAVDQLVEIIKVLGTPTREEVRCMNPSYTDFRFPQIKAHPWHKVFHKRMPPEAIDLASRLLQYSPSLRCTALEACAHPFF aervvgtgsfg+v+qakcletgetvaikkvlqd+ryknrelq+mr +dhpnv++lkh+ffstt++de++lnlv+++vpe +y v+kh+s++nqr+pliyvklytyq++r+lay+h+v gvchrdikpqn+lv+p thq+k+cdfgsakvlv+ge+nisyicsryyrapelifga+ey t++diwsagcvlaelllgqplfpge++vdqlveiikvlgtptree++cmnp yt+f+fpqikahpwhkvf+kr+ppea+dl+srllqysp+lrctalea++hpff aervvgtgsfgvvfqakcletgetvaikkvlqdkryknrelqimrlldhpnvvalkhlffsttekdelylnlvleyvpetvyrvakhysklnqrlpliyvklytyqicralayihkvvgvchrdikpqnllvnpkthqlklcdfgsakvlvkgepnisyicsryyrapelifgateyttaidiwsagcvlaelllgqplfpgesgvdqlveiikvlgtptreeikcmnpnytefkfpqikahpwhkvfkkrlppeavdlvsrllqyspnlrctalealvhpff 587.3 3.2e-179 CMGC_GSK 509 Cluster-782.4062-2F PF00069.22 82 364 3 264 AERVVGTGSFGIVYQAKCLETGETVAIKKVLQDRRYKN------RELQLMRSMDHPNVISLKHCFFSttsrdEVFLNLVMDFVPENM-YNVLKhfsdSNQRMPLIYVKLYTYQLFRGLAYLHtVAGVCHRDIKPQNVLVDpLTHQVKICDFGSAKVLVPGEANISYICSRYYRAPELIfGAAEYRTSVDIWSAGCVLAELLLGQPLFP---GEN----AVDQLVEIIKVLGtptR--EEVRCMNPSytdfrfpqikahpwhkvfhkrmPPEAIDLASRLLQYSPSLRCTALEACAHPFF ++ +G+GsfG Vy+a+ etg++vA+Kk+ ++++ k+ rE++++++++hpn++ l+++f + + l lv+++v+++ ++l+ ++ ++ +k +++q+++gl+ylH +g++HrD+Kp+N+L+d + ++Ki+DFG ak l ++ s++++r+Y+APE++ ++ ey ++vD+Ws+G++l+ell g+p+f+ g++ +dql++i+k+lg e+++ + ++ea+dl ++ll++ p+ R+ta e+++hp++ kleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee.....kdelylvleyveggeladlls....rkgslseeeakkiakqilegleylH.skgiiHrDlKpeNiLid.ekgelKitDFGlakelessskltsfvgtreYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg...etkeklpeasel......................seeakdllkkllkkdpkkRltaeellqhpyl 212.3 5.3e-65 Protein kinase domain 509 Cluster-782.4062-2F PF07714.14 83 286 4 212 ERVVGTGSFGIVYQAKCL----ETGETVAIKKVLQDRRYK-----NRELQLMRSMDHPNVISLKHCFFstT--SrdevfLNLVMDFVPEN-MYNVLKHFsDSNQRMPLIYVKLYTYQLFRGLAYLHTVAgVCHRDIKPQNVLVDPlTHQVKICDFGSAKVLVPG---EANISYICSRYYRAPELIFGAAeYRTSVDIWSAGCVLAELLL-GQPLFPGENA ++ +G G+fG V+++++ ++ +va+K++ ++ + + +e+++m++++hpn+++l + + l +v+++v+++ + + L++ ++++++ l + +++q+ +G++yL+ + Hrd+ +NvL++ +++vki+DfG a+ + +++ + ++ + apE ++ + ++ D+Ws G +l E++ g+ +pg ++ gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvct..keep.....llivteyvegGdLlkfLrkk.eekekltlkdllsfalqiAkGmeyLeskk.lvHrdlaarNvLlse.nkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekk.ftsksDvWsfGvllwEiftlgeepypglsn 91.0 4.7e-28 Protein tyrosine kinase 509 Cluster-782.4113-1R TKL-Pl-6 17 276 1 253 ELRELGSGTYGTVFHGKWRGSDVAIKRIKKACFSarsseqERMTRDFWREAQILSNLHHPNVVAFYGVVPDGAGRTLATVTEFMANGSLRNVLIKKDKSLDRRKKLIIAMDAAFGMEYLHSKNIVHFDLKCDNLLVNLRDPLRPICKVGDFGLSRIKRNTLVSGGVRGTLPWMAPELLNgSTTRVSEKVDVFSFGITLWEILTGEEPYANLHCGAIIGGIVKNTLRPHIPEKCDPEWRILMDQCWSAEPEARPSFTEITN elrelGsGt+G+v+++kwrg+dvaikr+kk +f+ e+++++f++ea+ils+L+hpnvva+yGvv dg+g +latvtef+ ngslr+vl kkd++ldrrk+++ia+daa+GmeYLhsk++vhfdLk+dnLLv+lr+p rpickv+DfGLs+ikr+tlvsggvrGtLPwmapell+ s+++vsekvDv+sfGi lWe+ltgeePya+l++gai++givk++lrp++Pe+cdpeWr Lm++Cw++ep+arPsfte+++ elrelGsGtfGevylakwrgtdvaikrlkkslfa......eklvseflseaeilskLrhpnvvalyGvvkdgpggslatvteflrngslrsvlskkdrkldrrkrilialdaalGmeYLhskavvhfdLktdnLLvdlrepqrpickvaDfGLskikretlvsggvrGtLPwmapellr.sskevsekvDvysfGivlWelltgeePyaslnlgaillgivkeelrpavPescdpeWreLmeaCwapepaarPsftevae 431.9 6.3e-132 TKL-Pl-6 343 Cluster-782.4113-1R PF07714.14 17 278 3 260 ELRELGSGTYGTVFHGKWR------GSDVAIKRIKKacfsarsSEQERMTRDFWREAQILSNLHHPNVVAFYGVVPdgAGRTLATVTEFMANGSLRNVLIKK--DKSLDRRKKLIIAMDAAFGMEYLHSKNIVHFDLKCDNLLVNLrdplRPICKVGDFGLSRIK---RNTLVSGGVRGTLPWMAPELLNGSTtrVSEKVDVFSFGITLWEILT-GEEPYANLHCGAIIGGIvKNTLRPHIPEKCDPEWRILMDQCWSAEPEARPSFTEITNRL ++lG+G++G+V++g+++ +va+K +k+ + +e+ +++f +ea+i+++l+hpn+v+++gv+ +++l vte++++G+L++ L kk +++l+ +++l +a++ A GmeyL+sk++vH dl + N L++ + ++k++DfGL+r ++ ++++ + + WmapE l+ ++ +++k Dv+sfG++lwEi+t geepy++l+ ++ + k+ r + pekc +e+ lm qCw+++pe Rp+f+e++++l lgkklGeGafGeVvegtlkgekekkevkvavKtlke.......eateeekeefleeakimkklkhpnivkllgvct..keepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlse....nkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekk..ftsksDvWsfGvllwEiftlgeepypglsneevlekl.kegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 218.5 5.9e-67 Protein tyrosine kinase 343 Cluster-782.4113-1R PF00069.22 16 276 2 260 EELRELGSGTYGTVFHGK--WRGSDVAIKRIKKACFSARSSeqermtRDFWREAQILSNLHHPNVVAFYGVVPDgaGRTLATVTEFMANGSLRNVLIkKDKSLDRRKKLIIAMDAAFGMEYLHSKNIVHFDLKCDNLLVNlRDPLrpiCKVGDFGLSRIKRNTLVSGGVRGTLPWMAPELLngSTTRVSEKVDVFSFGITLWEILTGEEPYA----------NLHCGAIIGGIV-KNTLRPHIPEKCDPEWRILMDQCWSAEPEARPSFTEITN e+l++lG+G++G+V+ ++ ++g vA+K+ikk + ++ ++++rE +il +l+hpn+v +y+v+ + ++l v+e++ +g+l ++l +++sl+ ++ ia + g+eylHsk+i+H DlK +N+L++ ++ K++DFGl++ +++ + gt ++APE+l +++++s+kvDv+s G++l+e+ltg++p++ +l+ i i+ ++++ + ++++++e + l++++++ +p+ R++++e+ + ekleklGeGsfGkVykaveketgkivAvKkikkekakkkke......kkvlrEikilkklkhpnivrlyevfee..kdelylvleyveggeladlls.rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLid.ekge...lKitDFGlakelessskltsfvgtreYlAPEvl..keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellq 168.6 1.1e-51 Protein kinase domain 343 Cluster-782.4116-2F CMGC_CDK-CDK8 31 339 1 311 YDVIGKIGEGTYGLVFLAKIKS--NRSKPIAIKKFKQSKDGDGVSPTAIREIMLLREISHENVVKLANVHINHADMSLYLAFDYAEHDLYEIIRHHRDKVNQSINQYTVKSLLWQLLNGLNYLHSNWIIHRDLKPSNILVMGDGEEQGVVKIADFGLARIYQAPLKPLSDNGVVVTIWYRAPELLLGAKHYTSAVDMWAVGCIFAELLTLKPLFQGQEVKGTPNPFQLDQLDKIFKVLGHPTQEKWPTLVNLPHWQSDLQHIQGQKYENAGLYHSVPLSTKNPAYDLLSKMLEYDPRKRLTAAQALEHEYF y+++gkigegtyglv+la+ k +r+++iaikkfkqsk+gdgvsptaireimllrei+hen+vkl nvhin+admslylafdyae+dlyeiirhhr+kv++s+n+ytvksllwqllnglnylhsnwiihrdlkpsnilvmg++ee+g+vkiadfglari+qapl+plsdngvvvtiwyrapelllgakhytsavd+wavgcifaelltlkplfqg+e k +pnpfqldqldkifkvlghpt +kwptl++lphw+++ q+iq++ky+n+gly v l+ k++a+dllskmleydp+kr+ta+qaleheyf yelvgkigegtyglvylarskepahrgtkiaikkfkqskegdgvsptaireimllreirhenivklvnvhinradmslylafdyaeydlyeiirhhrekvelslnaytvksllwqllnglnylhsnwiihrdlkpsnilvmgedeehgivkiadfglarifqaplrplsdngvvvtiwyrapelllgakhytsavdlwavgcifaelltlkplfqgveaksspnpfqldqldkifkvlghptvdkwptlevlphwaenrqniqakkydntglysivhlppkseafdllskmleydplkritaeqaleheyf 619.6 7.8e-189 CMGC_CDK-CDK8 903 Cluster-782.4116-2F PF00069.22 31 339 1 264 YDVIGKIGEGTYGLVFLAKiKSNRSKPIAIKKFKQSKDGDGVSPTAIREIMLLREISHENVVKLANVHINhaDMSLYLAFDYAEHD-LYEIIRhhrdkVNQSINQYTVKSLLWQLLNGLNYLHSNWIIHRDLKPSNILVMGDGEeqgvVKIADFGLARIYQAPLKplsDNGVVVTIWYRAPELLlGAKHYTSAVDMWAVGCIFAELLTLKPLFQGQEVKGTpNPFQLDQLDKIFKVLGhPTQEKWPTLVNLphwqsdlqhiqgqkyenaglyhsvplstKNPAYDLLSKMLEYDPRKRLTAAQALEHEYF y ++ k+GeG++G V+ a+ +++++k +A+Kk+k++k+ + +++rEi +l++++h+n+v+l +v + + +lyl ++y+e++ l ++++ ++s+++ ++k++++q+l+gl+ylHs+ iiHrDlKp+NiL+ +ge +Ki+DFGla+ ++ k + +v+t +Y+APE+l ++++y+++vD+W++G+i++ellt kp+f+g++ k + + +ldql ki+k+lg +t+ek+p+ +l ++ a dll+k+l++dp+kRlta+++l+h+y+ yekleklGeGsfGkVykav.eketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee..kdelylvleyveggeladlls.....rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekge....lKitDFGlakelesssk...ltsfvgtreYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkek.vekeldqlekilkilg.etkeklpeasel............................seeakdllkkllkkdpkkRltaeellqhpyl 236.2 2.6e-72 Protein kinase domain 903 Cluster-782.4116-2F PF07714.14 35 238 5 202 GKIGEGTYGLVFLAKIK---SNRSKPIAIKKFKQSKDGDGvSPTAIREIMLLREISHENVVKLANVHInhADMSLYLAFDYAEH-DLYEIIRHHRDKvnQSINQYTVKSLLWQLLNGLNYLHSNWIIHRDLKPSNILVMGdgeeQGVVKIADFGLARIYQAPLKPLSDNGVVVTIWYRAPELLLGAKhYTSAVDMWAVGCIFAELLTL k+GeG++G V+ +++k ++++ +a+K++k++++ + + ++e+ ++++++h+n+vkl v + + +l++ ++y+e+ dL + +r++++k ++++ ++ s+ +q+ +G++yL+s+ ++Hrdl N+L+ + vvki+DfGLar + + ++++ + + + apE l k +ts+ D+W+ G + E++tl kklGeGafGeVvegtlkgekekkevkvavKtlkeeateee.keefleeakimkklkhpnivkllgvct..keepllivteyvegGdLlkfLrkkeek..ekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlse....nkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekk.ftsksDvWsfGvllwEiftl 113.1 8.9e-35 Protein tyrosine kinase 903 Cluster-782.4126-1F RLK-Pelle_DLSV 1 105 161 265 IGTYGYVPPEYVKRGVYSRKYDVYSFGVLLLQIISGKKTSDLYGANKNLNMLEHAYELWRNDNYKNFVDPSVDDAATTSKLKRYMQVGLLCVQERWEDRPSMLEV +gt+gY++Pey+ +g +s k DvysfGvl+l+i+sGkk+s+l+ +++ ++le+a++lw++++ +++vd+s+ ++a++++++r+++++llcvqe+ e+rp+m ev vgtlgYmaPeyalegqlseksDvysfGvlvleivsGkknsslkeeeeaeelleeawklweeekllelvdkslkeeaekeevlrcieiallcvqekpekrptmsev 108.8 2.2e-33 RLK-Pelle_DLSV 145 Cluster-782.4126-1F PF07714.14 6 108 172 259 YVPPEYVKRGVYSRKYDVYSFGVLLLQIIS-GKKTsdlyganknlnmlehaYELWRNDNYKNFVDPSVDDAATTSKLKRYMQVGLLCVQERWEDRPSMLEVSSM +++pE +k+++++ k Dv+sfGvll i++ g+++ y+ ++n + ++++ + ++ ++ ++ +++ C++e+ e+Rp++ e+ + WmapEslkekkftsksDvWsfGvllwEiftlgeep................ypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelvek 32.3 3.8e-10 Protein tyrosine kinase 145 Cluster-782.4126-1F PF00069.22 2 67 159 225 GTYGYVPPEYVKRGVYSRKYDVYSFGVLLLQIISGKKTSDLYGANK-NLNMLEH---AYELWRndnYKNF gt Y++PE +k+ ys+k Dv+s Gv+l+++++gk ++ + ++l++ +++ + +++ gtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg...etke 30.8 1.2e-09 Protein kinase domain 145 Cluster-782.4209-2F CAMK_CDPK 91 349 1 259 YDLGRELGRGEFGITYLCTDVDSGEKLACKSISKKKLRTAVDIEDVRREVEIMKHLPKHPNIVSLKGTYEDDSAVHIVMELCEGGELFDRIVARGHYTERAAAFIMRTIVEVVQMCHRHGVMHRDLKPENFLFANKKETAPLKAIDFGLSIFFKPGDRFNEIVGSPYYMAPEVLRRNYGPEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPKVSDNAKDLVKKMLDPDPSRRLTAQQVLEHPWL y lg+elGrGefG+++l+t+ +ge++A+Ksisk+kl++a d+edvrrev+i+khl +h+n+v+lkg+yed+++vh+vmelceggel+dri+arg+y+eraaa ++r+i+evv++cH++gv+hrDlKPeNfl+++k+e+aplkaiDFGls f+k+g+r+++ivGspyy+aPEvl+r+yg+e+dvWsaGvilyillcgvppfwaete+++++a++++ +dfk++pw++vs++akdlv+++L+ dp++Rlta+qvLehpWl yelgkelGrGefGvvrlatekatgeevAvKsiskrklskaedvedvrrevkilkhlsghknvvqlkgayedkdsvhlvmelceggelldrilargkyseraaakvvrqilevvaacHskgvvhrDlKPeNflltskeedaplkaiDFGlsvfvkegerledivGspyyvaPEvlkrsygkeadvWsaGvilyillcgvppfwaeteeeifkavlkaeldfksepwksvseeakdlvrrlLekdpkkRltaeqvLehpWl 425.1 8.2e-130 CAMK_CDPK 626 Cluster-782.4209-2F PF00069.22 91 349 1 264 YDLGRELGRGEFGITYLCTDVDSGEKLACKSISKKKLRTAVDiEDVRREVEIMKHLPkHPNIVSLKGTYEDDSAVHIVMELCEGGELFDRIVARGHYTERAAAFIMRTIVEVVQMCHRHGVMHRDLKPENFLFANKKEtapLKAIDFGLSIFFKPGDRFNEIVGSPYYMAPEVL-RRNYGPEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRS---------VIDFKRDPWPKVSDNAKDLVKKMLDPDPSRRLTAQQVLEHPWL y ++lG+G+fG y +++ ++g++ A+K i+k+k + + ++v+rE++i+k+l hpniv l++++e+++ +++v+e++eggel+d++ ++g+++e+ a +i+++i+e ++ +H++g++HrDlKpeN+L+ +k+e lK +DFGl+ ++ + +++++vg+++Y+APEvl +++y+++vDvWs+Gvily ll+g ppf++e+++ ++++++ ++k + + ++s++akdl+kk+l+ dp++Rlta+++l+hp+l yekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklk.hpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekge...lKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 259.8 1.7e-79 Protein kinase domain 626 Cluster-782.4209-2F PF07714.14 93 345 3 258 LGRELGRGEFGITYLCTDV----DSGEKLACKSISKKKLRTAvdIEDVRREVEIMKHLpKHPNIVSLKGTYEDDSAVHIVMELCEGGELFDRIVAR---GHYTERAAAFIMRTIVEVVQMCHRHGVMHRDLKPENFLFANkkeTAPLKAIDFGLSIFFKPGDRF---NEIVGSPYYMAPEVLRR-NYGPEVDVWSAGVILYILLC-GVPPFWAETEQGVAQAIirsvIDFKRDPWPK-VSDNAKDLVKKMLDPDPSRRLTAQQVLE lg++lG+G+fG + +t ++ k a K++++++ +++ e++ +e++imk+l khpniv+l g + +++ + iv+e++egG+L + + ++ + t + +++ i + ++ +++ ++Hrdl N L ++ + k DfGL+ + d+ +e + +mapE+l++ ++ + DvWs Gv+l+ +++ g p++ +++ v++++ + kr + p+ ++++ ++l+k+ ++ dp++R t ++++e lgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateee..keefleeakimkkl.khpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlse...nkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevlekl....kegkrlekpekcpeelyelmkqCweedpeeRptfkelve 98.1 3.2e-30 Protein tyrosine kinase 626 Cluster-782.4229-1R RLK-Pelle_RLCK-XII-1 77 312 1 236 VYKGRLQNRRWIAVKKFPKLAWPDPEQFVEEAREVGKLRHRRLANLIGYCCDGDERLLVAEYMPYDTLAKHLFHWESQTIEWAMRLRVALYIAEALEYCSSQDRPLYHDLNAYRVLFDEDGDPRLSCFGLIKNSRDGKSYSTNLAYTPPEYLKNGRVTKESVIYSFGTVLLDLLSGKHIPPSHALDMISGKNVIPLMDSHLEGKFSTEEATIVVDLASQCLQSEPAQRPTTKDLLA vykg+l+++r+iavk+f+klawpd++qf+eea++vGklrh+rl+nliGyc++gderllvae+mp dtlakhlfhwe+q+++wamrlrvalyiaealeycss+++ lyhdlnayrvlfdedgdprlscfGl+knsrdgksystnlaytppeyl++grv+ esviysfgt+lldllsgkhippshald+i gkn+ l+ds+leg+fs+e+at +v+las+clq ep +rp +k l++ vykgkleekrliavkrfkklawpdakqfleeakavGklrhkrlvnliGycvegderllvaefmpndtlakhlfhwekqplkwamrlrvalyiaealeycsskglklyhdlnayrvlfdedgdprlscfGlmknsrdgksystnlaytppeylrtgrvipesviysfgtllldllsgkhippshaldlirgknllllldsalegqfsnedatelvrlasrclqleprerpnikslvs 442.4 2.5e-135 RLK-Pelle_RLCK-XII-1 564 Cluster-782.4229-1R PF07714.14 76 313 14 259 VVYKGRLQ-----NRRWIAVKKFPKLAWPD-PEQFVEEAREVGKLRHRRLANLIGYCCDGDERLLVAEYMPYDTLAKHLFHW-ESQTIEWAMRLRVALYIAEALEYCSSQDrPLYHDLNAYRVLFDEDGDPRLSCFGLIKNS------RDGKSYSTNLAYTPPEYLKNGRVTKESVIYSFGTVLLDLLSGKHIPpshaLDMISGKNVIPLMDSHLEGKFSTEEATIVVDLASQCLQSEPAQRPTTKDLLAA V++g+l+ ++ +avK++ + a + e+f+eea+ kl+h+++ +l+g c ++++ l+v ey+++ +L k+L + e+++++ l++al iA+++ey +s++ + dl a vL +e+ ++s fGL ++ ++ ++ +++ +++pE lk++++t++s ++sfG++l +++ + p + +s ++v+ ++++ + + ++ + + +l +qC++++p++Rpt k+l+ eVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskk.lvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep....ypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelvek 96.3 1.1e-29 Protein tyrosine kinase 564 Cluster-782.4229-1R PF00069.22 76 312 14 260 VVYKGR-LQNRRWIAVKKFPKLAWPDP--EQFVEEAREVGKLRHRRLANLIGYCCDGDERLLVAEYMPYDTLAKHLFhwESQTIEWAMRLRVALYIAEALEYCSSQDrPLYHDLNAYRVLFDEDGDPRLSCFGLIKNSRDGK---SYSTNLAYTPPEYLKNGRVTKESVIYSFGTVLLDLLSGKHIPPSHALD-----MISG-KNVIPLM-DSHLEGKFSTEEATIVVDLASQCLQSEPAQRPTTKDLLA +Vyk++ ++++ +AvKk+ k + +++++E + + kl+h+++ +l++++ + de++lv ey++ ++la++l ++++++ + ++a i+e+ley+ s+ ++ Dl +L+de+g+ +++ FGl k+ + ++ s+ Y +PE lk+ +++k++ ++s G +l+ ll+gk++ +++ + ++ ++++ ++ +++++ + +e + dl +++l+ +p +R+t ++ll+ kVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls..rkgslseeeakkiakqilegleylHskg.iiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellq 87.9 4.5e-27 Protein kinase domain 564 Cluster-782.4243-0R CMGC_DYRK-YAK 251 378 96 221 HAVLKVCYNNTFSSMi*ILRGLALMKDAGIIHCDLKPENILLRTSVRAAEIKIIDFGSACMEDRTVYSYIQSRYYRSPEVLLGYQYTTAIDMWSFGCIVAELFLGLPLFPGASEFDLLRRMIKILGEH l++ + ++fs +l +l+l++da+iihcdlkpenill +sv++ae+k+idfGsac+ed+tvysyiqsr+yrspevllGy+yttaidmws+Gc++aelflGlplfpGase+dll+r+i++lg++ lkglslklvrlfskq..lldalsllrdariihcdlkpenilltesvksaelklidfGsacledktvysyiqsrfyrspevllGyryttaidmwslGcvaaelflGlplfpGaseydlllrlieklgkq 222.7 5.8e-68 CMGC_DYRK-YAK 1014 Cluster-782.4243-0R PF00069.22 268 376 107 221 ILRGLALMKDAGIIHCDLKPENILLRTSVRaaeIKIIDFGSACMEDRT--VYSYIQSRYYRSPEVLLGYQYTTAIDMWSFGCIVAELFLGLPLFP---GAS----EFDLLRRMIKILG il+gl+ + ++giiH+DlKpeNiL+ ++ +Ki+DFG a+ +++ + s++ +r+Y++PEvl + +y++++D+Ws G+i++el+ g p+f+ g + e+d l +++kilg ilegleylHskgiiHrDlKpeNiLidekge...lKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg 94.8 3.5e-29 Protein kinase domain 1014 Cluster-782.4243-0R PF07714.14 270 367 115 215 RGLALMKDAGIIHCDLKPENILLRTsvrAAEIKIIDFGSACME--DRTVYSY---IQSRYYRSPEVLLGYQYTTAIDMWSFGCIVAELFL-GLPLFPGASEFDL +G++ +++ ++H dl N+Ll++ +ki DfG a d + ++ + + +pE+l ++t++ D+WsfG ++ E+f g +pg s+ ++ kGmeyLeskklvHrdlaarNvLlse...nkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneev 37.2 1.3e-11 Protein tyrosine kinase 1014 Cluster-782.4243-1R CMGC_DYRK-YAK 119 237 1 119 IVKDMLGHGTFGQVAKCWVPETNSFLAVKIIKNLPAYYQQALVEVSILTTLNKKFDPEDQNHIVRIYDYFVHQRHLCIAFELLDSNLYELIKLNQFRGLSLRIVRLFSKQVMHAFFVFR +vkd+lG+GtfGqvakc+v+etn+++avk+ikn+payy+qa ve+++l++lnkk dp+d++hivr++dyf +++hlci+felld+nlyel+k n+++glsl++vrlfskq+++a+ ++r vvkdllGsGtfGqvakcyveetneyvavkviknqpayytqarveigllkllnkkydpddkyhivrlldyflyeehlcivfelldenlyellkknslkglslklvrlfskqlldalsllr 189.0 1e-57 CMGC_DYRK-YAK 1013 Cluster-782.4243-1R PF00069.22 119 232 2 110 IVKDMLGHGTFGQVAKCWVPETNSFLAVKIIKNLPAYY---QQALVEVSILTTLNkkfdpedQNHIVRIYDYFVHQRHLCIAFELLDSN-LYELIKlnQ-FRgLSLRIVRLFSKQVMHA ++ lG G+fG+V k+ et+ AvK+ik+ a +++l E++il +l+ ++ivr+y++f ++++l++ +e+++ + l +l++ + ls + ++ + kq++++ ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklk.......hpnivrlyevfeekdelylvleyveggeladlls..rkgs.lseeeakkiakqileg 40.3 1.6e-12 Protein kinase domain 1013 Cluster-782.4246-0R RLK-Pelle_LRR-III 410 671 1 264 EVLGKGSVGTSYKAVLEEGTIVVVKRLKDV-AASKKEFEQQMEVLGRIKHENVLPLRAFYYSKDEKLLVFDYLPAGSLSALLHGSRGSGHTPLDWDNRMRIALCTARGLAHLHTSG--KVVHGNIKSSNVLLKQDNrEACVSDFGLNQLFSSSTPPNHRVMGYRAPEVLETRRVTFKSDVYSFGVLLLELLTGKAPNQASLGEEGIDLPRWVQSVVREEWTAEVFDIELMRYHNVEEEMVQLLQIGMACVASVPDQRPAMQEVVR evLGkgsvgt+Ykavleeg++v+Vkrlk+v aa++kefe+++e lg+++H+nv+plra+yyskdEkLlv+dy+p+gsL++llhgsr+s++tpldw++r++ial +arGla+lh++ k+vHgn+kssn+Ll++d ea++sd+gL++l++s++ ++r++gyraPE+ ++r+++ ksDVYsfGv+lLElltgk+p++as ee++dlp+wv+svv+ee+taevfd el+++++ eee+v+llq+++aCva+ p++Rp m+evv+ evLGkgsvgtvYkavleegavvaVkrlkevaaaerkefeeevealgklrHpnvvplrayyyskdEkLlvydyvpngsLasllhgsrsssrtpldwearlkialgvarGlaylheesekklvHgnlkssniLldadl.earisdygLarllasaaaasaralgyraPElakarkasqksDVYsfGvvlLElltgkspskasseeeevdlpkwvrsvveeektaevfdvelvkekeaeeelvellqvalaCvaaspekRpkmkevvk 388.0 1.5e-118 RLK-Pelle_LRR-III 803 Cluster-782.4246-0R PF00069.22 410 671 5 260 EVLGKGSVGTSYKAV-LEEGTIVVVKRLKDVAASKKE---FEQQMEVLGRIKHENVLPLRAFYYSKDEKLLVFDYLPAGSLSALLHgsrgsGHTPLDWDNRMRIALCTARGLAHLHtSGKVVHGNIKSSNVLLKqDNREACVSDFGLNQLFSSSTPPNHRVM--GYRAPEVLETRRVTFKSDVYSFGVLLLELLTGKAPNQASLGEE----GIDLPRWVQSVVReewtaeVFDIELMRYHNVEEEMVQLLQigmACVASVPDQRPAMQEVVR e lG+Gs+G+ ykav e+g iv+vK++k a+kk+ + + +++l ++kh+n++ l ++++kde +lv++y++ g+l ll+ ++ l+ ++ +ia +++gl++lH s +++H +K++N+L++ +++e ++DFGl + ++ss++ +++v+ Y+APEvl++++++ k+Dv+s Gv+l+elltgk p +++ g+e +d ++ +++ + +l + ++++ee+ +ll+ +++ p +R+ ++e+++ eklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls.....rkgslseeeakkiakqilegleylH.skgiiHrDlKpeNiLid.ekgelKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg......etkeklpeaselseeakdllk...kllkkdpkkRltaeellq 136.4 7.1e-42 Protein kinase domain 803 Cluster-782.4246-0R PF07714.14 410 672 5 259 EVLGKGSVGTSYKAVLE-----EGTIVVVKRLKDVAASK--KEFEQQMEVLGRIKHENVLPLRAFYYSKDEKLLVFDYLPAGSLSALLHGSrgSGHTPLDWDNRMRIALCTARGLAHLHTSgKVVHGNIKSSNVLLKQdNREACVSDFGLNQLF-----SSSTPPNHRVMGYRAPEVLETRRVTFKSDVYSFGVLLLELLT-GKAPnqaslgeegidlprwVQSVVREEWTAEVfdIELMRYHNVEEEMVQLLQIGMACVASVPDQRPAMQEVVRM + lG+G+ G+ +++ l+ + + v+vK lk+ a ++ +ef ++++++ ++kh+n++ l ++++++++ l+v++y++ G+L+ L+ + + +++l+ ++ +++al A+G+++L+ k+vH ++ + NvLl++ n+ + +sDfGL + +++ ++ + + apE+l+++++t ksDv+sfGvll E++t g+ p ++++ ee ++ + e r ++ e+ +l ++ + C+++ p++Rp ++e+v+ kklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk..eekekltlkdllsfalqiAkGmeyLesk.klvHrdlaarNvLlse.nkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep...............ypglsneevlekl..kegkrlekpekcpeelyelmkqCweedpeeRptfkelvek 125.6 1.4e-38 Protein tyrosine kinase 803 Cluster-782.4303-0R CMGC_GSK 98 380 1 283 AERVVGTGSFGVVFQAKCLETGETVAIKKVLQDRRYKNRELQLMRTMDHPNVVSLKHCFFSTTSKDELFLNLVMEFVPETMYRVVKHYSNTNQRMPLIYVKLYTYQIFRGLAYMHTVAGVCHRDLKPQNVLVNPLTHQVKICDFGSAKVLVKGEANISYICSRFYRAPELIFGATEYTNSIDIWSAGCVLAELLLGQPLFPGENAVGQLVEIIKVLGTPTREEIRCMNPNYTDFRFPQIKAHPWHKVFHKRMPPEAIDLASRLLQYSPSLRCTALEACAHPFF aervvgtgsfgvvfqakcletgetvaikkvlqd+ryknrelq+mr++dhpnvv+lkh+ffstt+kdel+lnlv+e+vpet+yrv+khys++nqr+pliyvklytyqi+r+lay+h+v gvchrd+kpqn+lvnp thq+k+cdfgsakvlvkge+nisyicsr+yrapelifgateyt++idiwsagcvlaelllgqplfpge++v qlveiikvlgtptreei+cmnpnyt+f+fpqikahpwhkvf+kr+ppea+dl+srllqysp+lrctalea++hpff aervvgtgsfgvvfqakcletgetvaikkvlqdkryknrelqimrlldhpnvvalkhlffsttekdelylnlvleyvpetvyrvakhysklnqrlpliyvklytyqicralayihkvvgvchrdikpqnllvnpkthqlklcdfgsakvlvkgepnisyicsryyrapelifgateyttaidiwsagcvlaelllgqplfpgesgvdqlveiikvlgtptreeikcmnpnytefkfpqikahpwhkvfkkrlppeavdlvsrllqyspnlrctalealvhpff 603.8 2.9e-184 CMGC_GSK 587 Cluster-782.4303-0R PF00069.22 96 380 1 264 YMAERVVGTGSFGVVFQAKCLETGETVAIKKVLQDRRYKN------RELQLMRTMDHPNVVSLKHCFFSttsKDELFlnLVMEFVPETM-YRVVKhysnTNQRMPLIYVKLYTYQIFRGLAYMHtVAGVCHRDLKPQNVLVNpLTHQVKICDFGSAKVLVKGEANISYICSRFYRAPELIfGATEYTNSIDIWSAGCVLAELLLGQPLFP---GEN----AVGQLVEIIKVLGtptreE----------IrcmnpnytdfrfpqikahpwhkvfhkrmPPEAIDLASRLLQYSPSLRCTALEACAHPFF y ++ +G+GsfG+V++a+ etg++vA+Kk+ ++++ k+ rE++++++++hpn+v l+++f + kdel+ lv+e+v+++ ++++ +++ ++ +k +++qi++gl+y+H +g++HrDlKp+N+L++ + ++Ki+DFG ak l +++ s++++r Y+APE++ +++ey++++D+Ws+G++l+ell g+p+f+ g++ + ql++i+k+lg e + ++ea+dl ++ll++ p+ R+ta e+++hp++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee...kdely..lvleyveggeladlls....rkgslseeeakkiakqilegleylH.skgiiHrDlKpeNiLid.ekgelKitDFGlakelessskltsfvgtreYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.....etkeklpeasel............................seeakdllkkllkkdpkkRltaeellqhpyl 213.3 2.5e-65 Protein kinase domain 587 Cluster-782.4303-0R PF07714.14 99 299 4 209 ERVVGTGSFGVVFQAKCL----ETGETVAIKKVLQDRRYK-----NRELQLMRTMDHPNVVSLKHCFFsttS--KdelfLNLVMEFVPETMYRVVKHYSNTNQRMPLIYVKLYTYQIFRGLAYMHTVAgVCHRDLKPQNVLVNPlTHQVKICDFGSAKVLVKG---EANISYICSRFYRAPELIFGATeYTNSIDIWSAGCVLAELLL-GQPLFPG ++ +G G+fG V+++++ ++ +va+K++ ++ + + +e+++m++++hpn+v+l + + + l +v+e+v++ + + +++++++ l + +++qi +G++y++ + Hrdl +NvL++ +++vki+DfG a+ + k +++ + ++ + apE ++ + +t + D+Ws G +l E++ g+ +pg gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvct...keep....llivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskk.lvHrdlaarNvLlse.nkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekk.ftsksDvWsfGvllwEiftlgeepypg 93.9 6.1e-29 Protein tyrosine kinase 587 Cluster-782.4443-2R AGC_RSK-2 545 830 2 258 PIKPLGSGDTGSVHLVELCGTGHLFAMKAMDKGMMLSRNKVHRACAEREILDMLDHPFLPALYASFQTKTHICLITDYCPGGELFLLLDRQPTKVLKEDAVRFYAAEVVVALEYLHCQGIIYRDLKPENVLLQSNGHVSLTDFDLSCLTSCKpeliipeinekkkhqkgqqapifmaepmrASNSFVGTEEYIAPEIITGAGHTSAVDWWALGILLYEMFYGYTPFRGKTRQKTFANVLHKDLKFPASKEVSLQAKQLMYRLLHRDPKHRLGSRGGANEVKQHPFF +k+lGsGd+gsv+lvel gt +lfa+k++dk ++ +r+k++ra+aereil++ldhPflp+lyasf+t++++cl++++cpgg+L+ l++rqp+kv++e+avrfyaaevv+aleylh++gi+yrdLkPenvl++++Gh+ ltDfDLs+ +s+k +snsfvGteey+aPeii+g+gh+savdWWalGillye++yg tPf+gk+r++t+anvl+k+l+fp++++vsl+a++l+ +ll++dpk+rlgs+ ga+e+k+hpff llkklGsGdigsvylvelrgtealfalkvldkealakrkklkraeaereilelldhPflptlyasfetekfvclvvefcpggdLhvlrerqpkkvfseeavrfyaaevvlaleylhalgivyrdLkPenvlvredGhimltDfDLslkasak.............................rsnsfvGteeylaPeiikgeghgsavdWWalGillyellygktPfkgknreetlanvlkkelefpeeaavsleardlirkllekdpkkrlgskrgaaeikkhpff 424.9 8.4e-130 AGC_RSK-2 967 Cluster-782.4443-2R PF00069.22 544 830 2 264 QPIKPLGSGDTGSVHLVELCGTGHLFAMKAMDKGMMLSRNKvHRACAEREILDMLDHPFLPALYASFQTKTHICLITDYCPGGELFLLLDrqPTKVLKEDAVRFYAAEVVVALEYLHCQGIIYRDLKPENVLLQSNGHVSLTDFDLSCLTSCKPEliipeinekkkhqkgqqapifmaepmraSNSFVGTEEYIAPEIITGAGHTSAVDWWALGILLYEMFYGYTPFRGKTRQKTFANVLHK-----------DLKFPASKEVSLQAKQLMYRLLHRDPKHRLGsrggANEVKQHPFF + ++ lG+G++G+V + tg+ +A+K ++k + ++++ +++ +E +il l+hp++ ly +f++k++++l+++y++ggel+ ll ++l+e+ ++++a++++ +leylH++gii+rDlKpeN+L++++g++ +tDF+l++ + + + +sfvgt+eY+APE++++ +++++vD+W+lG++lye+++g +pf+g+++++++++ l++ ++k+p +e+s +ak+l+ +ll++dpk+Rl+ a+e++qhp++ ekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls..rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk............................ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRlt....aeellqhpyl 215.1 7.2e-66 Protein kinase domain 967 Cluster-782.4443-2R PF07714.14 546 814 4 250 IKPLGSGDTGSVHLVELC----GTGHLFAMKAMDKGMMLSRnkVHRACAEREILDMLDHPFLPALYASFQTKTHICLITDYCPGGELFLLLDRQ-PTKVLKEDAVRFYAAEVVVALEYLHCQGIIYRDLKPENVLLQSNGHVSLTDFDLSCLTSCKPELiipeinekkKHQKGQQAPIFMAepmrasnsfvgteeyiAPEIITGAGHTSAVDWWALGILLYEMFY-GYTPFRGKtRQKTFANVLHKDLKFPASKEVSLQAKQLMYRLLHRDPKHR k lG+G G+V+ +l + a+K ++++++ ++ ++ + e +i+ l+hp + +l++ + +++++t+y++gG+L L ++ ++ l+ + + +a+++ ++eyL+ + ++ rdl NvLl++n +v ++Df L+ ++ + e k++++++ p+ apE+++ ts+ D W+ G+ll+E+f g +p++g +++++++ l+++ + ++ ++++ + ++lm + +++dp++R gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateee..keefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddey.........kkkeeaklpvkWm................apEslkekkftsksDvWsfGvllwEiftlgeepypgl.sneevleklkegkrlekpekcpeelyelmkqCweedpeeR 97.8 4.2e-30 Protein tyrosine kinase 967 Cluster-782.445-0F CMGC_RCK 162 206 123 167 LSPENLLVSKDIIKVADFGLAREIDSEPPYTEYVSTRWYRAPEIL l penllv+kd+ik+adfGlare++s+ppyteyvstrwyrape+l lkpenllvtkdvikiadfGlarevsskppyteyvstrwyrapevl 82.0 3.2e-25 CMGC_RCK 206 Cluster-782.445-0F PF00069.22 164 206 126 169 PENLLVS-KDIIKVADFGLAREIDSEPPYTEYVSTRWYRAPEIL peN+L++ k+ +K++DFGla+e++s+ ++t++v tr+Y+APE+l peNiLidekgelKitDFGlakelessskltsfvgtreYlAPEvl 42.7 2.8e-13 Protein kinase domain 206 Cluster-782.51-2F CMGC_GSK 118 400 1 283 AERIVGHGSFGVVFQAKCLETGETVAIKKVLQDKRYKNRELQTMRLLDHPNVVSLKHCFFSTTEKDELYLNLVLEYVPETLHRVVKHYNKLNQRTPLIYVKLYSYQIFRALSYIHRGIGVCHRDIKPQNLLVNPHTHQVKLCDFGSAKVLVKGEPNIYYICSRYYRAPELIFGATEYTTAIDIWSAGCVLAELLLGQPLFPGESGVDQLVEIIKVLGTPTREEIKCMNPNYTEYKFPQIKAHPWHKIFHKRMPPEAVDLVSRLLQYSPNLRCSALDALVHPFF aer+vg+gsfgvvfqakcletgetvaikkvlqdkryknrelq+mrlldhpnvv+lkh+ffsttekdelylnlvleyvpet++rv+khy+klnqr pliyvkly yqi+ral+yih+++gvchrdikpqnllvnp+thq+klcdfgsakvlvkgepni yicsryyrapelifgateyttaidiwsagcvlaelllgqplfpgesgvdqlveiikvlgtptreeikcmnpnyte+kfpqikahpwhk+f+kr+ppeavdlvsrllqyspnlrc+al+alvhpff aervvgtgsfgvvfqakcletgetvaikkvlqdkryknrelqimrlldhpnvvalkhlffsttekdelylnlvleyvpetvyrvakhysklnqrlpliyvklytyqicralayihkvvgvchrdikpqnllvnpkthqlklcdfgsakvlvkgepnisyicsryyrapelifgateyttaidiwsagcvlaelllgqplfpgesgvdqlveiikvlgtptreeikcmnpnytefkfpqikahpwhkvfkkrlppeavdlvsrllqyspnlrctalealvhpff 614.7 1.5e-187 CMGC_GSK 535 Cluster-782.51-2F PF00069.22 116 400 1 264 YMAERIVGHGSFGVVFQAKCLETGETVAIKKVLQDKRYKN------RELQTMRLLDHPNVVSLKHCFFStteKDELYlnLVLEYVPET-LHRVVKHYNKLNQRtpliYVKLYSYQIFRALSYIHrGIGVCHRDIKPQNLLVNpHTHQVKLCDFGSAKVLVKGEPNIYYICSRYYRAPELIfGATEYTTAIDIWSAGCVLAELLLGQPLFP---GES----GVDQLVEIIKVLGtptREEIKCMNP--NyteykfpqikahpwhkifhkrmPPEAVDLVSRLLQYSPNLRCSALDALVHPFF y ++ +G GsfG+V++a+ etg++vA+Kk+ ++k+ k+ rE++ ++ l+hpn+v l+++f + kdely lvleyv+++ l++++++ +l+++ +k + +qi+++l+y+H g++HrD+Kp+N+L++ ++ ++K++DFG ak l ++++ ++++r+Y+APE++ +++ey++++D+Ws+G++l+ell g+p+f+ g++ +dql++i+k+lg ++ k ++ ++ea dl+++ll++ p+ R++a ++l hp++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee...kdely..lvleyveggeladllsrkgslsee....eakkiakqilegleylH.skgiiHrDlKpeNiLid.ekgelKitDFGlakelessskltsfvgtreYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg...etkeklpeasel......................seeakdllkkllkkdpkkRltaeellqhpyl 212.2 5.7e-65 Protein kinase domain 535 Cluster-782.51-2F PF07714.14 119 321 4 211 ERIVGHGSFGVVFQAKCL----ETGETVAIKKVLQDKRYK-----NRELQTMRLLDHPNVVSLKHCFFsttEKDElyLNLVLEYVPE-TLHRVVKHYNKlNQRTPLIYVKLYSYQIFRALSYIHRgIGVCHRDIKPQNLLVNpHTHQVKLCDFGSAKVLVKGE---PNIYYICSRYYRAPELIFGATeYTTAIDIWSAGCVLAELLL-GQPLFPGES ++ +G+G+fG V+++++ ++ +va+K++ ++++ + +e+++m+ l+hpn+v+l + ++++ l +v+eyv++ +L++ +++ ++ ++++ l + +++qi ++++y+++ + Hrd+ +N L++ ++++vk++DfG a+ + k + + ++ + apE ++ + +t++ D+Ws G +l E++ g+ +pg s gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvct...keep..llivteyvegGdLlkfLrkkee.kekltlkdllsfalqiAkGmeyLes.kklvHrdlaarNvLls.enkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekk.ftsksDvWsfGvllwEiftlgeepypgls 85.7 2e-26 Protein tyrosine kinase 535 Cluster-782.657-0R CAMK_CAMKL-CHK1 68 323 1 256 YEVGRTIGEGTFAKVKFARNSETGQPVALKILDKDKVLKHKIAEQIKREVATMKLIKHPNVVRLYEVMASKTKIFIVLEFVTGGELFDKIVNHGRMQEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDAAGNLKVSDFGLSALSQQVKDDGLLHTTCGTPNYVAPEVLNDRGYDGATADLWSCGVILFVLLAGYLPFDDSNLMNLYNKISSAEFTCPPWISFNARKLITRILNPNPVTRITIPEILEDPWF ye+Gr++Gegtfakvk+ar+ etg+ va+k+ldk+kvlk+k++eqikre++++kl++hpnvvrl+ev+a+k+ki++vle+v+GGelf+ki+++gr++edearkyfqqli+avdychsrgvyhrdlkpenllld++gnlkvsdfGlsal++q+++dgllhttcGtP+yvaPevl+++gydga+ad+WscGvilfvllagylPf+d+nl++ly+ki++aef++p+w+s +a+kli+r+l+pnp triti eile++Wf yelGrllGegtfakvklardletgesvaikvldkekvlkaklveqikreisvlklvrhpnvvrllevlatkskiylvleyvkGGelfekiakkgrlkedearkyfqqlisavdychsrgvyhrdlkpenllldekgnlkvsdfGlsalaeqlredgllhttcGtPayvaPevlkkkgydgakadvWscGvilfvllagylPfedenlvelyrkilkaefklpkwlskeakklisrlldpnpetritieeileeeWf 455.8 3e-139 CAMK_CAMKL-CHK1 567 Cluster-782.657-0R PF00069.22 68 323 1 264 YEVGRTIGEGTFAKVKFARNSETGQPVALKILDKDKVLKHKIaEQIKREVATMKLIKHPNVVRLYEVMASKTKIFIVLEFVTGGELFDKIVNHGRMQEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDAAGNLKVSDFGLSALSQQVKDdglLHTTCGTPNYVAPEVLNDRGYdGATADLWSCGVILFVLLAGYLPFDDSNLMNLYN----------KI---SSAEFTCPPWISFNARKLITRILNPNPVTRITIPEILEDPWF ye+ +++GeG+f+kV a+++etg+ vA+K+++k+k k k +++ rE++ +k +khpn+vrlyev+ +k+++++vle+v ggel+d + ++g ++e+ea+k+++q++++++y+Hs+g+ HrDlKpeN+L+d g+lK++DFGl++ ++ ++ l++ +gt++Y+APEvl++++y ++++D+Ws+Gvil+ ll+g pf +++ + ++ ki ++ ++ + +s +a++l++++l+ +p +R+t+ e+l++p++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeney.skkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 247.3 1.1e-75 Protein kinase domain 567 Cluster-782.657-0R PF07714.14 70 319 3 258 VGRTIGEGTFAKVKFARNS----ETGQPVALKILDKDKVLKHkiAEQIKREVATMKLIKHPNVVRLYEVMASKTKIFIVLEFVTGGELFDKIVNH---GRMQEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDAAGNLKVSDFGLSALSQQVKDDGLLHTTCGTPNYVAPEVLNDRGYDgATADLWSCGVILFVLLA-GYLPFDDSNLMNLYNKISSA-EFTCPPWISFNARKLITRILNPNPVTRITIPEILE +g+++GeG+f++V ++ + ++ + va+K+l++++ ++ e++ +e+++mk +khpn+v+l+ v+ ++ +++iv+e+v+gG+L + + ++ +++ ++ ++ +q+ ++++y +s+ + Hrdl N Ll+ k+sDfGL+ ++ ++ +++ +++apE+l+++ + +D Ws Gv+l+ ++ g p+ + + +++++k+++ + ++p ++ + +l+++ ++ +p R t+ e++e lgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateee..keefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkft.sksDvWsfGvllwEiftlgeepypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelve 129.4 9.6e-40 Protein tyrosine kinase 567 Cluster-782.695-2F CMGC_RCK 343 622 1 280 YKIIKEVGTGTFGSVWRALNKQSGEVVAIKKMKKKFYSWEECKNLREVKSLLKMNHPNIVKLKEVIRENDVLFFVFEYMECNLYQLMKDRKRLFSEAEVRTWCFQVFQGLAYMHQRGYFHRDLKPENLLVSKDIIKVADFGLAREIDSEPPYTEYVSTRWYRAPEILLRSPTYGPAVDMWAMGALMAELFTLRPLFPGSSDADEIYKICCVIGSPTKNRWPHGLDLASAISYQFPQVAGGDLSLLIPGVSEDAISLITSLCSWDPCKRPTALETLQHPFF yk++ke+g gtfgsvw+a+nk+++evvaikkmk+kfysweec nlrevksl k+nhpnivklkevirend+lffvfey+ecnlyql+kdr++ fseaevr+++fq++q+l+ymh+rGyfhrdlkpenllv+kd+ik+adfGlare++s+ppyteyvstrwyrape+ll+s++y +avd+wa+Ga++ael++lrplfpG+s++deiykic+v+G+p+++ +++gl+la++++++fpq++g +l+ lip +s++ai+li++lcswdp+krpta e+lqhpff ykvlkelgdgtfgsvwkainketnevvaikkmkrkfysweeclnlrevkslrklnhpnivklkevirendelffvfeylecnlyqlikdrekafseaevrnfafqilqaleymhkrGyfhrdlkpenllvtkdvikiadfGlarevsskppyteyvstrwyrapevllqssvytsavdlwavGailaellslrplfpGasevdeiykicsvlGtpdeqtfaeglklaeslkfkfpqlsgtklaelipsasaeaidlisklcswdpkkrptaaealqhpff 516.6 1.1e-157 CMGC_RCK 732 Cluster-782.695-2F PF00069.22 343 622 1 264 YKIIKEVGTGTFGSVWRALNKQSGEVVAIKKMKKKFYSWEEC-KNLREVKSLLKMNHPNIVKLKEVIRENDVLFFVFEYMECN-LYQLMKdRKRLFSEAEVRTWCFQVFQGLAYMHQRGYFHRDLKPENLLVS-KDIIKVADFGLAREIDSEPPYTEYVSTRWYRAPEILlRSPTYGPAVDMWAMGALMAELFTLRPLFP---GSS----DADEIYKICCVIGsPTKNRWPHGLDLasaisyqfpqvaggdlsllipgvSEDAISLITSLCSWDPCKRPTALETLQHPFF y+ ++++G+G+fG+V +a++k++g+ vA+Kk+kk+ + ++ k lrE+k l k++hpniv+l+ev++e+d l++v+ey+e++ l +l++ rk +se+e++ ++ q+++gl+y+H++g +HrDlKpeN+L++ k+ +K++DFGla+e++s+ ++t++v tr+Y+APE+l ++ y+++vD+W++G +++el+t +p+f+ g++ ++d+++ki+ ++g +tk+ +p+ +l se+a++l+++l+++dp kR+ta e lqhp++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls.rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtreYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.etkeklpeasel.......................seeakdllkkllkkdpkkRltaeellqhpyl 246.6 1.8e-75 Protein kinase domain 732 Cluster-782.695-2F PF07714.14 344 534 2 202 KIIKEVGTGTFGSVWRALNK----QSGEVVAIKKMKKKFYSWEECKNLREVKSLLKMNHPNIVKLKEVIRENDVLFFVFEYMEC-NLYQLMKDR--KRLFSEAEVRTWCFQVFQGLAYMHQRGYFHRDLKPENLLVS-KDIIKVADFGLAREIDSEPPYT----EYVSTRWYrAPEILLRSPtYGPAVDMWAMGALMAELFTL ++ k++G G+fG+V+++ k ++ va+K++k++ + e+ + l+e+k + k++hpnivkl v+ +++ l++v+ey+e +L + ++++ k+ ++ ++ +++q+ +G++y++++ + Hrdl N L+s ++++k++DfGLar+i ++ y+ + ++ +W+ apE+l ++ + + D+W+ G l+ E+ftl elgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWm.apEslkekk.ftsksDvWsfGvllwEiftl 125.1 2e-38 Protein tyrosine kinase 732 Cluster-782.696-2F CMGC_RCK 343 622 1 280 YKIIKEVGTGTFGSVWRALNKQSGEVVAIKKMKKKFYSWEECKNLREVKSLLKMNHPNIVKLKEVIRENDVLFFVFEYMECNLYQLMKDRKRLFSEAEVRTWCFQVFQGLAYMHQRGYFHRDLKPENLLVSKDIIKVADFGLAREIDSEPPYTEYVSTRWYRAPEILLRSPTYGPAVDMWAMGALMAELFTLRPLFPGSSDADEIYKICCVIGSPTKNRWPHGLDLASAISYQFPQVAGGDLSLLIPGVSEDAISLITSLCSWDPCKRPTALETLQHPFF yk++ke+g gtfgsvw+a+nk+++evvaikkmk+kfysweec nlrevksl k+nhpnivklkevirend+lffvfey+ecnlyql+kdr++ fseaevr+++fq++q+l+ymh+rGyfhrdlkpenllv+kd+ik+adfGlare++s+ppyteyvstrwyrape+ll+s++y +avd+wa+Ga++ael++lrplfpG+s++deiykic+v+G+p+++ +++gl+la++++++fpq++g +l+ lip +s++ai+li++lcswdp+krpta e+lqhpff ykvlkelgdgtfgsvwkainketnevvaikkmkrkfysweeclnlrevkslrklnhpnivklkevirendelffvfeylecnlyqlikdrekafseaevrnfafqilqaleymhkrGyfhrdlkpenllvtkdvikiadfGlarevsskppyteyvstrwyrapevllqssvytsavdlwavGailaellslrplfpGasevdeiykicsvlGtpdeqtfaeglklaeslkfkfpqlsgtklaelipsasaeaidlisklcswdpkkrptaaealqhpff 516.1 1.6e-157 CMGC_RCK 872 Cluster-782.696-2F PF00069.22 343 622 1 264 YKIIKEVGTGTFGSVWRALNKQSGEVVAIKKMKKKFYSWEEC-KNLREVKSLLKMNHPNIVKLKEVIRENDVLFFVFEYMECN-LYQLMKdRKRLFSEAEVRTWCFQVFQGLAYMHQRGYFHRDLKPENLLVS-KDIIKVADFGLAREIDSEPPYTEYVSTRWYRAPEILlRSPTYGPAVDMWAMGALMAELFTLRPLFP---GSS----DADEIYKICCVIGsPTKNRWPHGLDLasaisyqfpqvaggdlsllipgvSEDAISLITSLCSWDPCKRPTALETLQHPFF y+ ++++G+G+fG+V +a++k++g+ vA+Kk+kk+ + ++ k lrE+k l k++hpniv+l+ev++e+d l++v+ey+e++ l +l++ rk +se+e++ ++ q+++gl+y+H++g +HrDlKpeN+L++ k+ +K++DFGla+e++s+ ++t++v tr+Y+APE+l ++ y+++vD+W++G +++el+t +p+f+ g++ ++d+++ki+ ++g +tk+ +p+ +l se+a++l+++l+++dp kR+ta e lqhp++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls.rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtreYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.etkeklpeasel.......................seeakdllkkllkkdpkkRltaeellqhpyl 246.1 2.5e-75 Protein kinase domain 872 Cluster-782.696-2F PF07714.14 344 534 2 202 KIIKEVGTGTFGSVWRALNK----QSGEVVAIKKMKKKFYSWEECKNLREVKSLLKMNHPNIVKLKEVIRENDVLFFVFEYMEC-NLYQLMKDR--KRLFSEAEVRTWCFQVFQGLAYMHQRGYFHRDLKPENLLVS-KDIIKVADFGLAREIDSEPPYT----EYVSTRWYrAPEILLRSPtYGPAVDMWAMGALMAELFTL ++ k++G G+fG+V+++ k ++ va+K++k++ + e+ + l+e+k + k++hpnivkl v+ +++ l++v+ey+e +L + ++++ k+ ++ ++ +++q+ +G++y++++ + Hrdl N L+s ++++k++DfGLar+i ++ y+ + ++ +W+ apE+l ++ + + D+W+ G l+ E+ftl elgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWm.apEslkekk.ftsksDvWsfGvllwEiftl 124.6 2.7e-38 Protein tyrosine kinase 872 Cluster-782.697-0F CMGC_RCK 311 542 49 280 QSLLKMNHPNIVKLKEVIRENDVLFFVFEYMECNLYQLMKDRKRLFSEAEVRTWCFQVFQGLAYMHQRGYFHRDLKPENLLVSKDIIKVADFGLAREIDSEPPYTEYVSTRWYRAPEILLRSPTYGPAVDMWAMGALMAELFTLRPLFPGSSDADEIYKICCVIGSPTKNRWPHGLDLASAISYQFPQVAGGDLSLLIPGVSEDAISLITSLCSWDPCKRPTALETLQHPFF +sl k+nhpnivklkevirend+lffvfey+ecnlyql+kdr++ fseaevr+++fq++q+l+ymh+rGyfhrdlkpenllv+kd+ik+adfGlare++s+ppyteyvstrwyrape+ll+s++y +avd+wa+Ga++ael++lrplfpG+s++deiykic+v+G+p+++ +++gl+la++++++fpq++g +l+ lip +s++ai+li++lcswdp+krpta e+lqhpff kslrklnhpnivklkevirendelffvfeylecnlyqlikdrekafseaevrnfafqilqaleymhkrGyfhrdlkpenllvtkdvikiadfGlarevsskppyteyvstrwyrapevllqssvytsavdlwavGailaellslrplfpGasevdeiykicsvlGtpdeqtfaeglklaeslkfkfpqlsgtklaelipsasaeaidlisklcswdpkkrptaaealqhpff 415.9 5.3e-127 CMGC_RCK 792 Cluster-782.697-0F PF00069.22 312 542 51 264 SLLKMNHPNIVKLKEVIRENDVLFFVFEYMECN-LYQLMKdRKRLFSEAEVRTWCFQVFQGLAYMHQRGYFHRDLKPENLLVS-KDIIKVADFGLAREIDSEPPYTEYVSTRWYRAPEILlRSPTYGPAVDMWAMGALMAELFTLRPLFP---GSS----DADEIYKICCVIGsPTKNRWPHGLDLasaisyqfpqvaggdlsllipgvSEDAISLITSLCSWDPCKRPTALETLQHPFF l k++hpniv+l+ev++e+d l++v+ey+e++ l +l++ rk +se+e++ ++ q+++gl+y+H++g +HrDlKpeN+L++ k+ +K++DFGla+e++s+ ++t++v tr+Y+APE+l ++ y+++vD+W++G +++el+t +p+f+ g++ ++d+++ki+ ++g +tk+ +p+ +l se+a++l+++l+++dp kR+ta e lqhp++ ilkklkhpnivrlyevfeekdelylvleyveggeladlls.rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtreYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.etkeklpeasel.......................seeakdllkkllkkdpkkRltaeellqhpyl 199.8 3.4e-61 Protein kinase domain 792 Cluster-782.697-0F PF07714.14 312 454 54 202 SLLKMNHPNIVKLKEVIRENDVLFFVFEYMEC-NLYQLMKDR--KRLFSEAEVRTWCFQVFQGLAYMHQRGYFHRDLKPENLLVS-KDIIKVADFGLAREIDSEPPYT----EYVSTRWYrAPEILLRSPtYGPAVDMWAMGALMAELFTL + k++hpnivkl v+ +++ l++v+ey+e +L + ++++ k+ ++ ++ +++q+ +G++y++++ + Hrdl N L+s ++++k++DfGLar+i ++ y+ + ++ +W+ apE+l ++ + + D+W+ G l+ E+ftl imkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWm.apEslkekk.ftsksDvWsfGvllwEiftl 90.9 5.2e-28 Protein tyrosine kinase 792 Cluster-782.697-1F CMGC_RCK 238 290 1 53 YKIIKEVGTGTFGSVWRALNKQSGEVVAIKKMKKKFYSWEECKNLREVKVVKR yk++ke+g gtfgsvw+a+nk+++evvaikkmk+kfysweec nlrevk +++ ykvlkelgdgtfgsvwkainketnevvaikkmkrkfysweeclnlrevkslrk 80.0 1.3e-24 CMGC_RCK 792 Cluster-782.697-1F PF00069.22 238 290 1 54 YKIIKEVGTGTFGSVWRALNKQSGEVVAIKKMKKKFYSWEEC-KNLREVKVVKR y+ ++++G+G+fG+V +a++k++g+ vA+Kk+kk+ + ++ k lrE+k++k+ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkk 29.9 2.3e-09 Protein kinase domain 792 Cluster-782.877-0F RLK-Pelle_LRR-II 367 500 90 224 AKPPLDWGTRKRIALGAARGLLYLHEQCDPKIIHRDVKAANILLDDYCEAVVGDFGLAKLLDHHDSHITTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGQRALEFGKGANQKGAML-DWVSTTRNQ +kp+ldw trkrialGaarGl ylheqcdpkiihrdvkaanilld+++eavvgdfglaklld++dsh+ttavrGtvGhiapeylstG+ssektdvfG+GilllelitGqrale+++ a++++++l dwv + +++ gkpaldwetrkrialGaarGlsylheqcdpkiihrdvkaanilldeefeavvgdfglaklldkkdshvttavrGtvGhiapeylstGkssektdvfGyGilllelitGqralelsrlaededvllldwvkklkke 241.9 5.4e-74 RLK-Pelle_LRR-II 2318 Cluster-782.877-0F PF00069.22 198 295 2 101 SSKNILGKGGFGIVYKGC-LQDGTVVAVKRLKDGNAIGGE-IQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGKKIFQVTQVT + ++ lG+G+fG Vyk++ ++g vAvK++k +a + ++++E++++ h+n++rly+++ ++ e++lv ++++g++a++l+ k++++ +++ ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeak 44.7 6.8e-14 Protein kinase domain 2318 Cluster-782.877-0F PF00069.22 375 491 99 210 TRKRIALGAARGLLYLHEQCdpkIIHRDVKAANILLDDYCEAVVGDFGLAKLLDHHDShiTTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGQRALEFGKGANQKGAML + k+ia ++gl ylH+++ iiHrD+K +NiL+d+ e ++DFGlak l+++ + +t + gt +APE l++ + s+k+Dv++ G++l+el+tg+ ++ kg +++ ++l eakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekel 79.4 1.8e-24 Protein kinase domain 2318 Cluster-782.877-0F PF07714.14 200 476 4 205 KNILGKGGFGIVYKGCLQ-----DGTVVAVKRLKDGNAIGGEIQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGKkifqvtqvtrtpystnc*kanfcsiklkhninhts*ialhshphi*wfllvltlriqilae*kftcpqakyfhvcclyiLAKPPLDWGTRKRIALGAARGLLYLHEQcdpKIIHRDVKAANILLDDYCEAVVGDFGLAKLL-DHHDSHITTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELIT-GQR ++ lG+G fG V++g l+ + + vavK lk+++ + +f +e+++++ h+n+++l+g+c+ + l+v ++++G++ + L+ k +k++l+ + ++al A+G+ yL+++ k++Hrd+ a N+Ll++ + ++DfGLa+ + ++++ + ++ + v +apE l++++ ++k+Dv+ fG+ll E++t g++ gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk...............................................................................eekekltlkdllsfalqiAkGmeyLesk...klvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgee 117.1 5.1e-36 Protein tyrosine kinase 2318 Cluster-782.878-0F RLK-Pelle_LRR-II 200 287 1 88 KNILGKGGFGIVYKGCLQDGTVVAVKRLKDGNAIGGEIQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGKK knilGkGgfg vykG+l+dgt+vavkrlk+ ++ gge+qfqteve+islavhrnllrl+Gfc+t+ erllvyp+m+ngsvasrl+ +k knilGkGgfgkvykGrladgtlvavkrlkeeesaggelqfqtevelislavhrnllrliGfcttsterllvypymengsvasrlrelk 145.6 1.3e-44 RLK-Pelle_LRR-II 2397 Cluster-782.878-0F PF00069.22 198 296 2 102 SSKNILGKGGFGIVYKGC-LQDGTVVAVKRLKDGNAIGGE-IQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGKKIFQVTQVTR + ++ lG+G+fG Vyk++ ++g vAvK++k +a + ++++E++++ h+n++rly+++ ++ e++lv ++++g++a++l+ k++++ +++ + ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakk 45.1 5.3e-14 Protein kinase domain 2397 Cluster-782.878-0F PF07714.14 200 286 4 95 KNILGKGGFGIVYKGCLQ-----DGTVVAVKRLKDGNAIGGEIQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGK ++ lG+G fG V++g l+ + + vavK lk+++ + +f +e+++++ h+n+++l+g+c+ + l+v ++++G++ + L+ k gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk 42.3 3.4e-13 Protein tyrosine kinase 2397 Cluster-782.878-2F RLK-Pelle_LRR-II 315 448 90 224 AKPPLDWGTRKRIALGAARGLLYLHEQCDPKIIHRDVKAANILLDDYCEAVVGDFGLAKLLDHHDSHITTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGQRALEFGKGANQKGAML-DWVSTTRNQ +kp+ldw trkrialGaarGl ylheqcdpkiihrdvkaanilld+++eavvgdfglaklld++dsh+ttavrGtvGhiapeylstG+ssektdvfG+GilllelitGqrale+++ a++++++l dwv + +++ gkpaldwetrkrialGaarGlsylheqcdpkiihrdvkaanilldeefeavvgdfglaklldkkdshvttavrGtvGhiapeylstGkssektdvfGyGilllelitGqralelsrlaededvllldwvkklkke 241.9 5.6e-74 RLK-Pelle_LRR-II 2397 Cluster-782.878-2F PF00069.22 323 439 99 210 TRKRIALGAARGLLYLHEQCdpkIIHRDVKAANILLDDYCEAVVGDFGLAKLLDHHDShiTTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGQRALEFGKGANQKGAML + k+ia ++gl ylH+++ iiHrD+K +NiL+d+ e ++DFGlak l+++ + +t + gt +APE l++ + s+k+Dv++ G++l+el+tg+ ++ kg +++ ++l eakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekel 79.4 1.7e-24 Protein kinase domain 2397 Cluster-782.878-2F PF07714.14 318 424 100 205 PLDWGTRKRIALGAARGLLYLHEQcdpKIIHRDVKAANILLDDYCEAVVGDFGLAKLL-DHHDSHITTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELIT-GQR +l+ + ++al A+G+ yL+++ k++Hrd+ a N+Ll++ + ++DfGLa+ + ++++ + ++ + v +apE l++++ ++k+Dv+ fG+ll E++t g++ kltlkdllsfalqiAkGmeyLesk...klvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgee 65.9 2.2e-20 Protein tyrosine kinase 2397 Cluster-782.880-0F RLK-Pelle_LRR-II 200 287 1 88 KNILGKGGFGIVYKGCLQDGTVVAVKRLKDGNAIGGEIQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGKK knilGkGgfg vykG+l+dgt+vavkrlk+ ++ gge+qfqteve+islavhrnllrl+Gfc+t+ erllvyp+m+ngsvasrl+ +k knilGkGgfgkvykGrladgtlvavkrlkeeesaggelqfqtevelislavhrnllrliGfcttsterllvypymengsvasrlrelk 146.2 8.5e-45 RLK-Pelle_LRR-II 1694 Cluster-782.880-0F PF00069.22 198 296 2 102 SSKNILGKGGFGIVYKGC-LQDGTVVAVKRLKDGNAIGGE-IQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGKKIFQVTQVTR + ++ lG+G+fG Vyk++ ++g vAvK++k +a + ++++E++++ h+n++rly+++ ++ e++lv ++++g++a++l+ k++++ +++ + ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakk 45.6 3.6e-14 Protein kinase domain 1694 Cluster-782.880-0F PF07714.14 200 286 4 95 KNILGKGGFGIVYKGCLQ-----DGTVVAVKRLKDGNAIGGEIQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGK ++ lG+G fG V++g l+ + + vavK lk+++ + +f +e+++++ h+n+++l+g+c+ + l+v ++++G++ + L+ k gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk 42.9 2.2e-13 Protein tyrosine kinase 1694 Cluster-782.880-2F RLK-Pelle_LRR-II 315 448 90 224 AKPPLDWGTRKRIALGAARGLLYLHEQCDPKIIHRDVKAANILLDDYCEAVVGDFGLAKLLDHHDSHITTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGQRALEFGKGANQKGAML-DWVSTTRNQ +kp+ldw trkrialGaarGl ylheqcdpkiihrdvkaanilld+++eavvgdfglaklld++dsh+ttavrGtvGhiapeylstG+ssektdvfG+GilllelitGqrale+++ a++++++l dwv + +++ gkpaldwetrkrialGaarGlsylheqcdpkiihrdvkaanilldeefeavvgdfglaklldkkdshvttavrGtvGhiapeylstGkssektdvfGyGilllelitGqralelsrlaededvllldwvkklkke 242.5 3.7e-74 RLK-Pelle_LRR-II 1693 Cluster-782.880-2F PF00069.22 323 439 99 210 TRKRIALGAARGLLYLHEQCdpkIIHRDVKAANILLDDYCEAVVGDFGLAKLLDHHDShiTTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGQRALEFGKGANQKGAML + k+ia ++gl ylH+++ iiHrD+K +NiL+d+ e ++DFGlak l+++ + +t + gt +APE l++ + s+k+Dv++ G++l+el+tg+ ++ kg +++ ++l eakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekel 80.0 1.1e-24 Protein kinase domain 1693 Cluster-782.880-2F PF07714.14 318 424 100 205 PLDWGTRKRIALGAARGLLYLHEQcdpKIIHRDVKAANILLDDYCEAVVGDFGLAKLL-DHHDSHITTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELIT-GQR +l+ + ++al A+G+ yL+++ k++Hrd+ a N+Ll++ + ++DfGLa+ + ++++ + ++ + v +apE l++++ ++k+Dv+ fG+ll E++t g++ kltlkdllsfalqiAkGmeyLesk...klvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgee 66.5 1.4e-20 Protein tyrosine kinase 1693 Cluster-782.881-0F RLK-Pelle_LRR-II 200 287 1 88 KNILGKGGFGIVYKGCLQDGTVVAVKRLKDGNAIGGEIQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGKK knilGkGgfg vykG+l+dgt+vavkrlk+ ++ gge+qfqteve+islavhrnllrl+Gfc+t+ erllvyp+m+ngsvasrl+ +k knilGkGgfgkvykGrladgtlvavkrlkeeesaggelqfqtevelislavhrnllrliGfcttsterllvypymengsvasrlrelk 145.6 1.3e-44 RLK-Pelle_LRR-II 2401 Cluster-782.881-0F PF00069.22 198 296 2 102 SSKNILGKGGFGIVYKGC-LQDGTVVAVKRLKDGNAIGGE-IQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGKKIFQVTQVTR + ++ lG+G+fG Vyk++ ++g vAvK++k +a + ++++E++++ h+n++rly+++ ++ e++lv ++++g++a++l+ k++++ +++ + ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakk 45.1 5.3e-14 Protein kinase domain 2401 Cluster-782.881-0F PF07714.14 200 286 4 95 KNILGKGGFGIVYKGCLQ-----DGTVVAVKRLKDGNAIGGEIQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGK ++ lG+G fG V++g l+ + + vavK lk+++ + +f +e+++++ h+n+++l+g+c+ + l+v ++++G++ + L+ k gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk 42.3 3.4e-13 Protein tyrosine kinase 2401 Cluster-782.881-2F RLK-Pelle_LRR-II 315 448 90 224 AKPPLDWGTRKRIALGAARGLLYLHEQCDPKIIHRDVKAANILLDDYCEAVVGDFGLAKLLDHHDSHITTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGQRALEFGKGANQKGAML-DWVSTTRNQ +kp+ldw trkrialGaarGl ylheqcdpkiihrdvkaanilld+++eavvgdfglaklld++dsh+ttavrGtvGhiapeylstG+ssektdvfG+GilllelitGqrale+++ a++++++l dwv + +++ gkpaldwetrkrialGaarGlsylheqcdpkiihrdvkaanilldeefeavvgdfglaklldkkdshvttavrGtvGhiapeylstGkssektdvfGyGilllelitGqralelsrlaededvllldwvkklkke 241.9 5.6e-74 RLK-Pelle_LRR-II 2401 Cluster-782.881-2F PF00069.22 323 439 99 210 TRKRIALGAARGLLYLHEQCdpkIIHRDVKAANILLDDYCEAVVGDFGLAKLLDHHDShiTTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGQRALEFGKGANQKGAML + k+ia ++gl ylH+++ iiHrD+K +NiL+d+ e ++DFGlak l+++ + +t + gt +APE l++ + s+k+Dv++ G++l+el+tg+ ++ kg +++ ++l eakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekel 79.4 1.8e-24 Protein kinase domain 2401 Cluster-782.881-2F PF07714.14 318 424 100 205 PLDWGTRKRIALGAARGLLYLHEQcdpKIIHRDVKAANILLDDYCEAVVGDFGLAKLL-DHHDSHITTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELIT-GQR +l+ + ++al A+G+ yL+++ k++Hrd+ a N+Ll++ + ++DfGLa+ + ++++ + ++ + v +apE l++++ ++k+Dv+ fG+ll E++t g++ kltlkdllsfalqiAkGmeyLesk...klvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgee 65.9 2.2e-20 Protein tyrosine kinase 2401 Cluster-782.882-0F RLK-Pelle_LRR-II 367 500 90 224 AKPPLDWGTRKRIALGAARGLLYLHEQCDPKIIHRDVKAANILLDDYCEAVVGDFGLAKLLDHHDSHITTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGQRALEFGKGANQKGAML-DWVSTTRNQ +kp+ldw trkrialGaarGl ylheqcdpkiihrdvkaanilld+++eavvgdfglaklld++dsh+ttavrGtvGhiapeylstG+ssektdvfG+GilllelitGqrale+++ a++++++l dwv + +++ gkpaldwetrkrialGaarGlsylheqcdpkiihrdvkaanilldeefeavvgdfglaklldkkdshvttavrGtvGhiapeylstGkssektdvfGyGilllelitGqralelsrlaededvllldwvkklkke 241.9 5.4e-74 RLK-Pelle_LRR-II 2323 Cluster-782.882-0F PF00069.22 198 295 2 101 SSKNILGKGGFGIVYKGC-LQDGTVVAVKRLKDGNAIGGE-IQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGKKIFQVTQVT + ++ lG+G+fG Vyk++ ++g vAvK++k +a + ++++E++++ h+n++rly+++ ++ e++lv ++++g++a++l+ k++++ +++ ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeak 44.7 6.9e-14 Protein kinase domain 2323 Cluster-782.882-0F PF00069.22 375 491 99 210 TRKRIALGAARGLLYLHEQCdpkIIHRDVKAANILLDDYCEAVVGDFGLAKLLDHHDShiTTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGQRALEFGKGANQKGAML + k+ia ++gl ylH+++ iiHrD+K +NiL+d+ e ++DFGlak l+++ + +t + gt +APE l++ + s+k+Dv++ G++l+el+tg+ ++ kg +++ ++l eakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekel 79.3 1.9e-24 Protein kinase domain 2323 Cluster-782.882-0F PF07714.14 200 476 4 205 KNILGKGGFGIVYKGCLQ-----DGTVVAVKRLKDGNAIGGEIQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGKkifqvtqvtrtpystnc*kanfcsiklkhninhts*ialhshphi*wfllvltlriqilae*kftcpqakyfhvcclyiLAKPPLDWGTRKRIALGAARGLLYLHEQcdpKIIHRDVKAANILLDDYCEAVVGDFGLAKLL-DHHDSHITTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELIT-GQR ++ lG+G fG V++g l+ + + vavK lk+++ + +f +e+++++ h+n+++l+g+c+ + l+v ++++G++ + L+ k +k++l+ + ++al A+G+ yL+++ k++Hrd+ a N+Ll++ + ++DfGLa+ + ++++ + ++ + v +apE l++++ ++k+Dv+ fG+ll E++t g++ gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk...............................................................................eekekltlkdllsfalqiAkGmeyLesk...klvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgee 117.1 5.1e-36 Protein tyrosine kinase 2323 Cluster-782.883-0F RLK-Pelle_LRR-II 200 287 1 88 KNILGKGGFGIVYKGCLQDGTVVAVKRLKDGNAIGGEIQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGKK knilGkGgfg vykG+l+dgt+vavkrlk+ ++ gge+qfqteve+islavhrnllrl+Gfc+t+ erllvyp+m+ngsvasrl+ +k knilGkGgfgkvykGrladgtlvavkrlkeeesaggelqfqtevelislavhrnllrliGfcttsterllvypymengsvasrlrelk 145.9 9.9e-45 RLK-Pelle_LRR-II 1942 Cluster-782.883-0F PF00069.22 198 296 2 102 SSKNILGKGGFGIVYKGC-LQDGTVVAVKRLKDGNAIGGE-IQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGKKIFQVTQVTR + ++ lG+G+fG Vyk++ ++g vAvK++k +a + ++++E++++ h+n++rly+++ ++ e++lv ++++g++a++l+ k++++ +++ + ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakk 45.4 4.2e-14 Protein kinase domain 1942 Cluster-782.883-0F PF07714.14 200 286 4 95 KNILGKGGFGIVYKGCLQ-----DGTVVAVKRLKDGNAIGGEIQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGK ++ lG+G fG V++g l+ + + vavK lk+++ + +f +e+++++ h+n+++l+g+c+ + l+v ++++G++ + L+ k gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk 42.7 2.6e-13 Protein tyrosine kinase 1942 Cluster-782.883-2F RLK-Pelle_LRR-II 315 448 90 224 AKPPLDWGTRKRIALGAARGLLYLHEQCDPKIIHRDVKAANILLDDYCEAVVGDFGLAKLLDHHDSHITTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGQRALEFGKGANQKGAML-DWVSTTRNQ +kp+ldw trkrialGaarGl ylheqcdpkiihrdvkaanilld+++eavvgdfglaklld++dsh+ttavrGtvGhiapeylstG+ssektdvfG+GilllelitGqrale+++ a++++++l dwv + +++ gkpaldwetrkrialGaarGlsylheqcdpkiihrdvkaanilldeefeavvgdfglaklldkkdshvttavrGtvGhiapeylstGkssektdvfGyGilllelitGqralelsrlaededvllldwvkklkke 242.2 4.4e-74 RLK-Pelle_LRR-II 1941 Cluster-782.883-2F PF00069.22 323 439 99 210 TRKRIALGAARGLLYLHEQCdpkIIHRDVKAANILLDDYCEAVVGDFGLAKLLDHHDShiTTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGQRALEFGKGANQKGAML + k+ia ++gl ylH+++ iiHrD+K +NiL+d+ e ++DFGlak l+++ + +t + gt +APE l++ + s+k+Dv++ G++l+el+tg+ ++ kg +++ ++l eakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekel 79.8 1.4e-24 Protein kinase domain 1941 Cluster-782.883-2F PF07714.14 318 424 100 205 PLDWGTRKRIALGAARGLLYLHEQcdpKIIHRDVKAANILLDDYCEAVVGDFGLAKLL-DHHDSHITTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELIT-GQR +l+ + ++al A+G+ yL+++ k++Hrd+ a N+Ll++ + ++DfGLa+ + ++++ + ++ + v +apE l++++ ++k+Dv+ fG+ll E++t g++ kltlkdllsfalqiAkGmeyLesk...klvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgee 66.3 1.7e-20 Protein tyrosine kinase 1941 Cluster-782.884-0F RLK-Pelle_LRR-II 367 500 90 224 AKPPLDWGTRKRIALGAARGLLYLHEQCDPKIIHRDVKAANILLDDYCEAVVGDFGLAKLLDHHDSHITTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGQRALEFGKGANQKGAML-DWVSTTRNQ +kp+ldw trkrialGaarGl ylheqcdpkiihrdvkaanilld+++eavvgdfglaklld++dsh+ttavrGtvGhiapeylstG+ssektdvfG+GilllelitGqrale+++ a++++++l dwv + +++ gkpaldwetrkrialGaarGlsylheqcdpkiihrdvkaanilldeefeavvgdfglaklldkkdshvttavrGtvGhiapeylstGkssektdvfGyGilllelitGqralelsrlaededvllldwvkklkke 241.9 5.4e-74 RLK-Pelle_LRR-II 2319 Cluster-782.884-0F PF00069.22 198 295 2 101 SSKNILGKGGFGIVYKGC-LQDGTVVAVKRLKDGNAIGGE-IQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGKKIFQVTQVT + ++ lG+G+fG Vyk++ ++g vAvK++k +a + ++++E++++ h+n++rly+++ ++ e++lv ++++g++a++l+ k++++ +++ ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeak 44.7 6.8e-14 Protein kinase domain 2319 Cluster-782.884-0F PF00069.22 375 491 99 210 TRKRIALGAARGLLYLHEQCdpkIIHRDVKAANILLDDYCEAVVGDFGLAKLLDHHDShiTTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGQRALEFGKGANQKGAML + k+ia ++gl ylH+++ iiHrD+K +NiL+d+ e ++DFGlak l+++ + +t + gt +APE l++ + s+k+Dv++ G++l+el+tg+ ++ kg +++ ++l eakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekel 79.4 1.8e-24 Protein kinase domain 2319 Cluster-782.884-0F PF07714.14 200 476 4 205 KNILGKGGFGIVYKGCLQ-----DGTVVAVKRLKDGNAIGGEIQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGKkifqvtqvtrtpystnc*kanfcsiklkhninhts*ialhshphi*wfllvltlriqilae*kftcpqakyfhvcclyiLAKPPLDWGTRKRIALGAARGLLYLHEQcdpKIIHRDVKAANILLDDYCEAVVGDFGLAKLL-DHHDSHITTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELIT-GQR ++ lG+G fG V++g l+ + + vavK lk+++ + +f +e+++++ h+n+++l+g+c+ + l+v ++++G++ + L+ k +k++l+ + ++al A+G+ yL+++ k++Hrd+ a N+Ll++ + ++DfGLa+ + ++++ + ++ + v +apE l++++ ++k+Dv+ fG+ll E++t g++ gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk...............................................................................eekekltlkdllsfalqiAkGmeyLesk...klvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgee 117.1 5.1e-36 Protein tyrosine kinase 2319 Cluster-782.885-0F RLK-Pelle_LRR-II 367 500 90 224 AKPPLDWGTRKRIALGAARGLLYLHEQCDPKIIHRDVKAANILLDDYCEAVVGDFGLAKLLDHHDSHITTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGQRALEFGKGANQKGAML-DWVSTTRNQ +kp+ldw trkrialGaarGl ylheqcdpkiihrdvkaanilld+++eavvgdfglaklld++dsh+ttavrGtvGhiapeylstG+ssektdvfG+GilllelitGqrale+++ a++++++l dwv + +++ gkpaldwetrkrialGaarGlsylheqcdpkiihrdvkaanilldeefeavvgdfglaklldkkdshvttavrGtvGhiapeylstGkssektdvfGyGilllelitGqralelsrlaededvllldwvkklkke 241.9 5.4e-74 RLK-Pelle_LRR-II 2314 Cluster-782.885-0F PF00069.22 198 295 2 101 SSKNILGKGGFGIVYKGC-LQDGTVVAVKRLKDGNAIGGE-IQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGKKIFQVTQVT + ++ lG+G+fG Vyk++ ++g vAvK++k +a + ++++E++++ h+n++rly+++ ++ e++lv ++++g++a++l+ k++++ +++ ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeak 44.7 6.8e-14 Protein kinase domain 2314 Cluster-782.885-0F PF00069.22 375 491 99 210 TRKRIALGAARGLLYLHEQCdpkIIHRDVKAANILLDDYCEAVVGDFGLAKLLDHHDShiTTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGQRALEFGKGANQKGAML + k+ia ++gl ylH+++ iiHrD+K +NiL+d+ e ++DFGlak l+++ + +t + gt +APE l++ + s+k+Dv++ G++l+el+tg+ ++ kg +++ ++l eakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekel 79.4 1.8e-24 Protein kinase domain 2314 Cluster-782.885-0F PF07714.14 200 476 4 205 KNILGKGGFGIVYKGCLQ-----DGTVVAVKRLKDGNAIGGEIQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGKkifqvtqvtrtpystnc*kanfcsiklkhninhts*ialhshphi*wfllvltlriqilae*kftcpqakyfhvcclyiLAKPPLDWGTRKRIALGAARGLLYLHEQcdpKIIHRDVKAANILLDDYCEAVVGDFGLAKLL-DHHDSHITTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELIT-GQR ++ lG+G fG V++g l+ + + vavK lk+++ + +f +e+++++ h+n+++l+g+c+ + l+v ++++G++ + L+ k +k++l+ + ++al A+G+ yL+++ k++Hrd+ a N+Ll++ + ++DfGLa+ + ++++ + ++ + v +apE l++++ ++k+Dv+ fG+ll E++t g++ gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk...............................................................................eekekltlkdllsfalqiAkGmeyLesk...klvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgee 117.1 5.1e-36 Protein tyrosine kinase 2314 Cluster-782.888-1R CAMK_OST1L 75 331 1 264 YELVKDIGSGNFGVARLMRNKETKELVAMKYIDRG-HRIDANVAREIINHRSLRHPNIIRFKEVVLTPSHLAIVMEYAAGGELFERICSAGRFSEDEARYFFQQLISGVNYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSLLHSRPKSTVGTPAYIAPEVLQR---REYDGKLADVWSCGVTLYVMLVGAYPFEDQEDP---KNFRKTIQRIMAVQYKIPDYVHISQDCRHLLSHIFVANPARRISIKDIKTHRWF ye+vkd+gsg+fGvarl+r+ketkelvA+K+i+rg +++d+nv+rEi+nhrsLrHpni+rfkevvltp+hla+vmEYa+ggel+e+++++gr+sedeary+fqQl+sgv+ycH++++++Rdlklen+lLdgs+ap+lkicDFg+skssl +s+pks+vGtpayiaPevl++ +eYdgk aDvwscGv+Lyvml+gayPfed+ed+ k+++kt+qri++v+ykip++v+is++cr+Lls+i+va+pa+Ri+i++ik+h Wf yevvkdlgsgsfGvarlvrdketkelvAvKlierglekvdenvkrEilnhrsLrHpnivrfkevvltpthlalvmEYadggelleyvskkgrlsedearylfqQlvsgvdycHrkgvvnRdlklenllLdgseapllkicDFgfskssledskpksrvGtpayiaPevlaaakakeYdgkkaDvwscGvvLyvmllgayPfedeedkkekkevkktlqrileveykipevvaiseecrdLlskilvadpakRitieeikehpWf 421.1 1.2e-128 CAMK_OST1L 509 Cluster-782.888-1R PF00069.22 75 331 1 264 YELVKDIGSGNFGVARLMRNKETKELVAMKYIDRGHRID---ANVAREIINHRSLRHPNIIRFKEVVLTPSHLAIVMEYAAGGELFERICSAGRFSEDEARYFFQQLISGVNYCHSMQICHRDLKLENTLLDGSPAprLKICDFGYSKSSLLHSRPKSTVGTPAYIAPEVLQRREYdGKLADVWSCGVTLYVMLVGAYPFEDQEDPKNFRKTIQR------IM-AVQYKIPDYVHISQDCRHLLSHIFVANPARRISIKDIKTHRWF ye ++ +G+G+fG+ +++ket++ vA+K i++ ++ + +v+rEi +++l+hpni+r++ev+ ++++l +v+ey+ ggel++++ g +se+ea+ +++q+++g++y+Hs++i+HrDlK eN L+d + lKi+DFG +k +s+ +s vgt+ Y+APEvl+++ey +k +DvWs+Gv+ly +l g pf+++++ ++++k +++ i+ ++ k+p ++s+++++ll+ ++ +p +R+++++++ h+++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekge..lKitDFGlakelessskltsfvgtreYlAPEvlkeney.skkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 238.6 4.8e-73 Protein kinase domain 509 Cluster-782.888-1R PF07714.14 77 326 3 257 LVKDIGSGNFGVARLM----RNKETKELVAMKYIDRGHRID--ANVAREIINHRSLRHPNIIRFKEVVLTPSHLAIVMEYAAGGELFERICSA---GRFSEDEARYFFQQLISGVNYCHSMQICHRDLKLENTLLDGspAPRLKICDFGYSKSS---LLHSRPKSTVGTPAYIAPEVLQRREYDGKlADVWSCGVTLYVMLV-GAYPFEDQeDPKNFRKTIqrimAVQYKIPDYVHISQDCRHLLSHIFVANPARRISIKDIK l k++G+G+fG ++++++ va+K ++++++ + +++ +e+ ++l+hpni+++ v++ ++l iv+ey++gG+L + + + +++ ++ f +q+ +G++y +s+++ Hrdl N Ll+ ki+DfG +++ ++ +++ ++apE+l+++++ k +DvWs Gv+l+ ++ g+ p+++ +++++ +++ +++++ +++++ +l+++ + ++p++R ++k++ lgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlse..nkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsk.sDvWsfGvllwEiftlgeepypgl.sneevlekl....kegkrlekpekcpeelyelmkqCweedpeeRptfkelv 116.1 1.1e-35 Protein tyrosine kinase 509 Cluster-782.961-0F RLK-Pelle_LRR-II 367 500 90 224 AKPPLDWGTRKRIALGAARGLLYLHEQCDPKIIHRDVKAANILLDDYCEAVVGDFGLAKLLDHHDSHITTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGQRALEFGKGANQKGAML-DWVSTTRNQ +kp+ldw trkrialGaarGl ylheqcdpkiihrdvkaanilld+++eavvgdfglaklld++dsh+ttavrGtvGhiapeylstG+ssektdvfG+GilllelitGqrale+++ a++++++l dwv + +++ gkpaldwetrkrialGaarGlsylheqcdpkiihrdvkaanilldeefeavvgdfglaklldkkdshvttavrGtvGhiapeylstGkssektdvfGyGilllelitGqralelsrlaededvllldwvkklkke 242.1 4.9e-74 RLK-Pelle_LRR-II 2123 Cluster-782.961-0F PF00069.22 198 295 2 101 SSKNILGKGGFGIVYKGC-LQDGTVVAVKRLKDGNAIGGE-IQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGKKIFQVTQVT + ++ lG+G+fG Vyk++ ++g vAvK++k +a + ++++E++++ h+n++rly+++ ++ e++lv ++++g++a++l+ k++++ +++ ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeak 44.9 6.2e-14 Protein kinase domain 2123 Cluster-782.961-0F PF00069.22 375 491 99 210 TRKRIALGAARGLLYLHEQCdpkIIHRDVKAANILLDDYCEAVVGDFGLAKLLDHHDShiTTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGQRALEFGKGANQKGAML + k+ia ++gl ylH+++ iiHrD+K +NiL+d+ e ++DFGlak l+++ + +t + gt +APE l++ + s+k+Dv++ G++l+el+tg+ ++ kg +++ ++l eakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekel 79.5 1.6e-24 Protein kinase domain 2123 Cluster-782.961-0F PF07714.14 200 476 4 205 KNILGKGGFGIVYKGCLQ-----DGTVVAVKRLKDGNAIGGEIQFQTEVEMISLAVHRNLLRLYGFCMTPIERLLVYPFMSNGSVASRLKGKkifqvtqvtrtpystnc*kanfcsiklkhninhts*ialhshphi*wfllvltlriqilae*kftcpqakyfhvcclyiLAKPPLDWGTRKRIALGAARGLLYLHEQcdpKIIHRDVKAANILLDDYCEAVVGDFGLAKLL-DHHDSHITTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELIT-GQR ++ lG+G fG V++g l+ + + vavK lk+++ + +f +e+++++ h+n+++l+g+c+ + l+v ++++G++ + L+ k +k++l+ + ++al A+G+ yL+++ k++Hrd+ a N+Ll++ + ++DfGLa+ + ++++ + ++ + v +apE l++++ ++k+Dv+ fG+ll E++t g++ gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk...............................................................................eekekltlkdllsfalqiAkGmeyLesk...klvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgee 117.3 4.5e-36 Protein tyrosine kinase 2123 Cluster-7827.0-2F CAMK_CDPK 4 262 1 259 FKLGKKLGQGQFGTTFLCVEKETGKEYACKSIAKRKLLTDDDVEDVRREIQIMHHLSGHLNVISIKGAYEDAVAVHVVMELCAGGELFDRIIQRGHYTERKAAELTRTIVGVVEACHSLGVMHRDLKPENFLFVDQKEESLLKTIDFGLSIFFKPGETFTDVVGSPYYVAPEVLRKRYGVEADVWSAGVIVYILLSGVPPFWDENEQGIFEQVLHGDLDFTSDPWPSISEEAKDLVRRMLVRDPKRRLTAHEVLCHPWV ++lgk+lG+G+fG++ l++ek+tg+e+A+Ksi+krkl +++dvedvrre++i++hlsgh nv+++kgayed+ +vh+vmelc+ggel+dri++rg+y+er+aa+++r+i+ vv+acHs gv+hrDlKPeNfl+ +++e++ lk+iDFGls f+k+ge+++d+vGspyyvaPEvl+++yg eadvWsaGvi+yill+gvppfw+e+e++if++vl+++ldf+s+pw+s+seeakdlvrr+L +dpk+Rlta++vL hpW+ yelgkelGrGefGvvrlatekatgeevAvKsiskrklskaedvedvrrevkilkhlsghknvvqlkgayedkdsvhlvmelceggelldrilargkyseraaakvvrqilevvaacHskgvvhrDlKPeNflltskeedaplkaiDFGlsvfvkegerledivGspyyvaPEvlkrsygkeadvWsaGvilyillcgvppfwaeteeeifkavlkaeldfksepwksvseeakdlvrrlLekdpkkRltaeqvLehpWl 416.6 3.3e-127 CAMK_CDPK 481 Cluster-7827.0-2F PF00069.22 5 262 2 264 KLGKKLGQGQFGTTFLCVEKETGKEYACKSIAKRKLLTDDDvEDVRREIQIMHHLSgHLNVISIKGAYEDAVAVHVVMELCAGGELFDRIIQRGHYTERKAAELTRTIVGVVEACHSLGVMHRDLKPENFLFVdQKEEslLKTIDFGLSIFFKPGETFTDVVGSPYYVAPEVL-RKRYGVEADVWSAGVIVYILLSGVPPFWDENEQGIFEQVLHG---------DLDFTSDPWPSISEEAKDLVRRMLVRDPKRRLTAHEVLCHPWV + +klG+G+fG+ + +veketgk++A+K i k+k +++ ++v+rEi+i+++l+ h n++ +++++e+ +++v+e++ ggel+d++ ++g+++e++a +++++i+ +e +Hs g++HrDlKpeN+L+ +k+e lK +DFGl+ ++ ++++t++vg+++Y+APEvl +++y+ ++DvWs+Gvi+y ll+g ppf++e+++ +e+ l+ + +++++ + ++seeakdl++++l +dpk+Rlta+e+l hp++ ekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklk.hpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLid.ekge..lKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 249.0 3.2e-76 Protein kinase domain 481 Cluster-7827.0-2F PF07714.14 5 256 2 256 KLGKKLGQGQFGTTFLCVEK----ETGKEYACKSIakRKLLTDDDVEDVRREIQIMHHLsGHLNVISIKGAYEDAVAVHVVMELCAGGELFDRIIQR---GHYTERKAAELTRTIVGVVEACHSLGVMHRDLKPENFLFVDqkeESLLKTIDFGLSIFFKPGET---FTDVVGSPYYVAPEVLRK-RYGVEADVWSAGVIVYILLS-GVPPFWDENEQGIFEQVLHGDLdftSDPWPSISEEAKDLVRRMLVRDPKRRLTAHEV +lgkklG+G+fG+ + + k ++ + a K++ ++ t+++ e++ +e++im++l h n++++ g++ ++ + +v+e+++gG+L + + ++ + t ++ ++++ i +e +s ++Hrdl N L + +++ k DfGL+ + ++ ++ + ++apE+l++ ++ +++DvWs Gv+++ +++ g p+++ +++ ++e++ +g + +++ee ++l+++ + +dp++R t +e+ elgkklGeGafGeVvegtlkgekekkevkvavKtl..keeateeekeefleeakimkkl.khpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlse...nkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevleklkegkr...lekpekcpeelyelmkqCweedpeeRptfkel 93.2 1e-28 Protein tyrosine kinase 481 Cluster-7911.3-2R STE_STE11 2 250 2 254 RGPLIGRGSSAAVYLATV-DSGELFAVKSTDLSCSSL-LQKEKYLISKLNSPYVVKCLGSDITCENNQkpVYNLFLEYVPGGTLSDQIVKQGGSLDESMIRFYTHQMLRGLDYLHSNGLVHCDIKGRNVLVAGDG-VKIADFGCAKLIGEGAKS---AFSGTPAYMSPEVARGEEQGFPADIWALGCTIIEMATGYSPWKELGDPVSALYRIGYSGESPEYPCRLSDNVKELLTKCLMKDPNERWTAAQLLKHPF +g l+G+g+ ++Vyla+ +sgel+avks++l+ ++ L+kE l+skL++p++v++lgs+++ e+++ +n++lEyv+gg+l++ + ++gg+l+es++r yt+q+l+GL+ylHs+g+vH+Dikg+N+lv +g vk+aDFG+ak ++e ++ ++gtp+ym+pev+r+ee+g+ aDiw+lGCt++em+tg +pw+el + v+al++ig+s+e Pe p +ls++ k+ l+kCl +dp+eR+taa+LL+hpF kgellGegafgsVylalnkesgellavksvelesaksaLekEikllskLkhpnivrylgseveeekse..elnillEyvsggslasllkrlggklseslvrkytrqileGLeylHskgivHrDikgaNilvdsngevklaDFGlakeveeeeslasksvkgtplymapevirkeelglaaDiwslGCtVlemltgkapwseleeevaalfkigkskelPeipeslseeakdFlskClqrdpaeRptaaeLLehpF 301.2 5e-92 STE_STE11 398 Cluster-7911.3-2R PF00069.22 5 251 6 264 LIGRGSSAAVYLAT-VDSGELFAVKSTDLSCSSLLQ-----KEKYLISKLNSPYVVKCLGSDITcennqKPVYNLFLEYVPGGTLSDQIVkQGGSLDESMIRFYTHQMLRGLDYLHSNGLVHCDIKGRNVLVA-GDGVKIADFGCAKLIGEGA-KSAFSGTPAYMSPEVARGEEQGFPADIWALGCTIIEMATGYSPWK---ELG------DPVSALYR-IGYSGESPEYPCRLSDNVKELLTKCLMKDPNERWTAAQLLKHPFF +G+Gs++ Vy a+ ++g+ +AvK + + + + +E ++ kl++p++v+++++ + k + l+leyv+gg+l d + + gsl+e+ ++++++q+l+gl+ylHs+g++H+D+K N+L+ + +Ki+DFG ak + ++ ++ f gt+ Y++PEv +++e + ++D+W+lG++++e+ tg p++ + d + ++++ +g + e+ + + ls+++k+ll+k+l kdp++R+ta++ll+hp++ klGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee.....kdelylvleyveggeladlls.rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 189.5 4.8e-58 Protein kinase domain 398 Cluster-7911.3-2R PF07714.14 6 247 7 258 IGRGSSAAVYLATVD-----SGELFAVKSTDLSCSS----LLQKEKYLISKLNSPYVVKCLGSDItcenNQKPvYNLFLEYVPGGTLSDQIVKQ--GGSLDESMIRFYTHQMLRGLDYLHSNGLVHCDIKGRNVLVA-GDGVKIADFGCAKLI----GEGAKSAFSGTPAYMSPEVARGEEQGFPADIWALGCTIIEMAT-GYSPWKELgDPVSALYRIgYSGESPEYPCRLSDNVKELLTKCLMKDPNERWTAAQLLK +G+G+ + V+ +t++ + avK+ + ++++ + +e +++kl+ p +vk+lg + +++p + + +eyv+gG+L++ + k+ +l+ + + +++q+ +G++yL+s+ lvH d+ rNvL++ ++ vki+DfG a+ i +k+ +m+pE+ + ++ +D+W+ G +++E++t g +p+++l ++ ++l ++ +g+ e p +++++el+++C+ +dp+eR t ++l++ lGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvct....keep.llivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypgl.sneevlekl.kegkrlekpekcpeelyelmkqCweedpeeRptfkelve 113.4 7.2e-35 Protein tyrosine kinase 398 Cluster-7921.0-1F RLK-Pelle_Extensin 1 117 22 136 VAIKRLTSGGQQGDKEFLVEVEMLSRLHHRNLVKLVGYytNRDSSQNLLCYELVPNGSLEAWLHGALGLNCPLDWDTRMKIALDAARGLAYLHEDSQPCVIHRDFKSSNILLESNFH va+k+lt++++qg++eflveve+lsrlhhrnlvkl+G+ ++++s++ll+yel+pnGs+e++lhg+ ++pldwd+r+kialdaarglaylhedsqp+vihrdfk+snille++f+ vavkkltrddkqgereflvevellsrlhhrnlvkllGi..caeeskrllvyelipnGsveshlhgsdkakapldwdarlkialdaarglaylhedsqprvihrdfkasnilleedft 189.1 8.6e-58 RLK-Pelle_Extensin 117 Cluster-7921.0-1F PF07714.14 1 115 31 140 VAIKRLTSGGQQG-DKEFLVEVEMLSRLHHRNLVKLVGYYTnrDSSQNLLCYELVPNGSLEAWLHGAlGLNCPLDWDTRMKIALDAARGLAYLHEDSqpcVIHRDFKSSNILLESN va+K l+++ ++ +efl e++++++l+h+n+vkl+g +t ++++ l+ e+v++G+L+ L+ + +l+ ++ +++al+ A+G++yL++ + ++Hrd + N+Ll++n vavKtlkeeateeekeefleeakimkklkhpnivkllgvct..keepllivteyvegGdLlkfLrkk.eekekltlkdllsfalqiAkGmeyLeskk...lvHrdlaarNvLlsen 68.1 4.6e-21 Protein tyrosine kinase 117 Cluster-7921.0-1F PF00069.22 1 114 27 133 VAIKRLTSGGQQGDKE--FLVEVEMLSRLHHRNLVKLVGYYTNrdSSQNLLCYELVPNGSLEAWLHgalgLNCPLDWDTRMKIALDAARGLAYLHEDSqpcVIHRDFKSSNILLES vA+K++ ++ +ke +l E+++l +l+h+n+v+l++++++ +++ +l+ e+v++g+l+ +l+ ++ l+ ++ kia ++gl+ylH+ + +iHrD K++NiL+++ vAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee..kdelylvleyveggeladlls....rkgslseeeakkiakqilegleylHskg...iiHrDlKpeNiLide 65.7 2.7e-20 Protein kinase domain 117 Cluster-7943.2-1F CMGC_CDK-CDK7 1 147 54 200 KDPNIIELIDAFPHKGNLHLVFEFMETDLEAVIRDRNIVLSPADIKSYLQMTLKGLAFCHKKWVLHRDMKPNNLLIGADGQLKLADFGLARIFGSPDRRFTHQVFARWYRAPELLFGARQYGPGVDVWAAACIFAELLLRRPFLQGS kd+niielida+p+k nlhlvfe+me+dleavirdrni+lspad+ksylqm+lkgla+chkkwvlhrd+kpnnllig+dgqlkladfglarifgspdrrfthqvfarwyrapellfga+qyg++vdvwaaacifaelllrrp+lqgs kdeniielidaypkkknlhlvfeymesdleavirdrniflspadvksylqmllkglavchkkwvlhrdlkpnnlligsdgqlkladfglarifgspdrrfthqvfarwyrapellfgakqygaavdvwaaacifaelllrrpllqgs 312.5 1.5e-95 CMGC_CDK-CDK7 147 Cluster-7943.2-1F PF00069.22 3 145 58 198 PNIIELIDAFPHKGNLHLVFEFMETD-LEAVIRdRNIVLSPADIKSYLQMTLKGLAFCHKKWVLHRDMKPNNLLIGADGQLKLADFGLARIFGSPDRrFTHQVFARWYRAPELLfGARQYGPGVDVWAAACIFAELLLRRPFLQ pni++l+++f +k +l+lv+e++e++ l+ +++ r+ +ls++++k++++ +l+gl+++H+k ++HrD+Kp+N+Li +g+lK++DFGla+ + s + +t++v r+Y+APE+l ++++y++ vDvW++++i++ell ++p ++ pnivrlyevfeekdelylvleyveggeladlls.rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk.ltsfvgtreYlAPEvl.keneyskkvDvWslGvilyelltgkppfs 150.1 4.8e-46 Protein kinase domain 147 Cluster-7943.2-1F PF07714.14 2 138 60 200 DPNIIELIDAFPHKGNLHLVFEFMET-DLEAVIRDR--NIVLSPADIKSYLQMTLKGLAFCHKKWVLHRDMKPNNLLIGADGQLKLADFGLARIF---GSPDRRFTHQVFARWYrAPELLFGARqYGPGVDVWAAACIFAELL pni++l+ + ++++l +v+e++e dL+ +r++ + l+ d+ s+ + kG+++ ++k ++Hrd+ N L+ + + k++DfGLar + ++ ++++ +W+ apE l+ + + DvW+ + E++ hpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWm.apEslkekk.ftsksDvWsfGvllwEif 62.6 2.3e-19 Protein tyrosine kinase 147 Cluster-7987.0-1R RLK-Pelle_LRR-I-1 1 197 70 265 LVYEYMHNGTLRDHILDSGNQKHLDWLARLQVAADAAKGLEYLHTGCNPSIIHRDVKTSNILLDINMRAKVSDFGLSRQA-EEDLTHISSVARGTVGYLDPEYYANQQLTEKSDVYSFGVVLLELISGRKPVSMeeDAADWSIVHWARSLIRKGDVISIIDPRLVGKVKIESVWRMAEVAIQCVEQYGSSRPRMNEII LvYeym++g+l++h+ ++ ++k+l+w +rl++a daa+GLeyLH+gc+p+iihrdvK++NiLl+ +++ak++dFGls+++ ee+ th+s+v++Gt+GYldpeyy+++qlteksDvysfGvvLleli+g++++s + ++siv+w+++ ++kgd+ +++dp+l g++++esvw+++e+a++cve+ +++Rp+m+e++ LvYeymsegslkehlsgkkkekvlsweerlkialdaaqGLeyLHkgckppiihrdvKstNiLlnekleakiadFGlsksfeeeeethvstvvaGtlGYldpeyyetnqlteksDvysfGvvLlelitgkeaisk..eeekvsivewvkqklakgdieevvdpklkgdydvesvwkvveialscveessaeRptmsevv 274.2 7.9e-84 RLK-Pelle_LRR-I-1 276 Cluster-7987.0-1R PF07714.14 1 197 78 257 LVYEYMHNGTLRDHILDSGNQKHLDWLARLQVAADAAKGLEYLHTGcnpSIIHRDVKTSNILLDINMRAKVSDFGLSRQA-EEDLTHISSVARGTVGYLDPEYYANQQLTEKSDVYSFGVVLLELIS-GRKPvsmeedaadwsivhwaRSLIRKGDVISIIDPRLVGKVKIESVWRMAEVAIQCVEQYGSSRPRMNEII +v ey+++G+L++++ ++ ++++l+ l++a++ AkG+eyL+ +++Hrd+ + N+Ll+ n+ +k+sDfGL+r+ ++d ++ ++ a+ v ++ pE ++++t+ksDv+sfGv+l E+++ g++p + +++ +v++ ++ + + + + +++e+ qC+e+ ++Rp+++e++ ivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLesk...klvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep................ypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelv 112.6 1.3e-34 Protein tyrosine kinase 276 Cluster-7987.0-1R PF00069.22 1 144 75 211 LVYEYMHNGTLRDHILdsgNQKHLDWLARLQVAADAAKGLEYLHTGCnpsIIHRDVKTSNILLDINMRAKVSDFGLSRQAEEDLThiSSVARGTVGYLDPEYYANQQLTEKSDVYSFGVVLLELISGRKPVSMEEDAA-DWSIVH lv ey+++g+l d++ ++++l+ ++a+ ++gleylH + iiHrD+K++NiL+d + K++DFGl++++e++ + + gt Yl PE +++ ++k+Dv+s Gv+l+el++g+ p s e++ +++++ lvleyveggeladlls...rkgslseeeakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeld 99.8 1.1e-30 Protein kinase domain 276 Cluster-8023.0-2F RLK-Pelle_RLCK-XII-1 8 242 1 235 VYEGRLQNRRWIAVKKFTKMAWPDPKQFAEEAKEVGKLRHKRLANLIGYCCDGDERLLVAEFMPNETLAKHLFHWENQTPEWAMRLRVALYIAEALDYCSAEGRPLYHDLNAYRVLFAENGDPRLSCFGLMKNSSDGKSYSTNLAYTPPEYLRNGRVTPESVAFSFGTILLDLLSGKHIPPSHALDMIRGKNILLLMDSHLEGNFSTEEATVVFGLASQCLQYEPRERPKTKDLV vy+g+l+++r+iavk+f+k+awpd+kqf+eeak+vGklrhkrl+nliGyc++gderllvaefmpn+tlakhlfhwe+q+ +wamrlrvalyiaeal+ycs +g+ lyhdlnayrvlf e+gdprlscfGlmkns dgksystnlaytppeylr+grv+pesv +sfgt+lldllsgkhippshald+irgkn+lll+ds+leg+fs+e+at ++ las+clq+eprerp++k lv vykgkleekrliavkrfkklawpdakqfleeakavGklrhkrlvnliGycvegderllvaefmpndtlakhlfhwekqplkwamrlrvalyiaealeycsskglklyhdlnayrvlfdedgdprlscfGlmknsrdgksystnlaytppeylrtgrvipesviysfgtllldllsgkhippshaldlirgknllllldsalegqfsnedatelvrlasrclqleprerpnikslv 447.1 8.7e-137 RLK-Pelle_RLCK-XII-1 242 Cluster-8023.0-2F PF07714.14 8 241 15 256 VYEGRLQ-----NRRWIAVKKFTKMAWPD-PKQFAEEAKEVGKLRHKRLANLIGYCCDGDERLLVAEFMPNETLAKHLFHW-ENQTPEWAMRLRVALYIAEALDYCSAEGrPLYHDLNAYRVLFAENGDPRLSCFGLMKNS------SDGKSYSTNLAYTPPEYLRNGRVTPESVAFSFGTILLDLLSGKHIPpshaLDMIRGKNILLLMDSHLEGNFSTEEATVVFGLASQCLQYEPRERPKTKDL V+eg+l+ ++ +avK++++ a + ++f eeak kl+h+++ +l+g c ++++ l+v e++++ +L k+L + e+++ + l++al iA++++y +++ + dl a vL +en ++s fGL+++ ++ ++ +++ +++pE l+++++t +s +sfG++l +++ + p + ++ +++l ++++ + + ++ + + l +qC++++p+eRp+ k+l VvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskk.lvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep....ypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkel 86.3 1.4e-26 Protein tyrosine kinase 242 Cluster-8023.0-2F PF00069.22 7 241 14 258 VVYEGR-LQNRRWIAVKKFTKMAWPDP--KQFAEEAKEVGKLRHKRLANLIGYCCDGDERLLVAEFMPNETLAKHLFhWENQTPEWAMRlRVALYIAEALDYCSAEGrPLYHDLNAYRVLFAENGDPRLSCFGLMKNSSDGK---SYSTNLAYTPPEYLRNGRVTPESVAFSFGTILLDLLSGKHIPP-----SHALDMIRG-KNILLLM-DSHLEGNFSTEEATVVFGLASQCLQYEPRERPKTKDL +Vy+++ ++++ +AvKk+ k + k++++E k + kl+h+++ +l++++ + de++lv e++++++la++l + + +e+ ++ ++a i+e+l+y+ ++g ++ Dl +L+ e+g+ +++ FGl k+ + ++ s+ Y +PE l++ ++++++ +s G il+ ll+gk++ + +++ +++ ++il ++ +++++ + +e + l +++l+++p++R+ ++l kVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls.rkgslseeeak.kiakqilegleylHskg.iiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeel 83.2 1.3e-25 Protein kinase domain 242 Cluster-8025.0-2R RLK-Pelle_RLCK-VIIa-2 9 175 2 183 IISEGIFGCVFKGWINENNLTATKPGYGTTVAIKQLTPKEFLGFDKWL----------HPNLIKLIAYCHEGNNLLLVYEFMPRGSLEDYLFERGTECLCWATRIKVAAGAARGLSFLHDAKNHVTHRYIDPVHILLDEEYNAKLSGLFLA-----DDKTYMSTQIVGTYAYAAPEYVVTGF ++ eG fG+v+kg+i+e++ +++k+g g++va+k+l ++ + g+ +wl hpnl+kli yc e ++ llvyE+m++gsle++lf+r +e l W+tr+k+a gaA+gl+fLh+a+++v +R + iLlde++nakls + la +dkt++st+++gty+YaaPeyv tG llGeGgfGsvykgvidektkaelkageglavavkklnkeglqghkewlaevefLgqlshpnlvkliGycledderllvyEymakgslenhlfrrssealsWetrlkialgaAkglafLheaekkviyRdfkasniLldedfnaklsdfglakegpeedkthvstrvmgtygYaaPeyvatGh 190.0 3.7e-58 RLK-Pelle_RLCK-VIIa-2 180 Cluster-8025.0-2R PF07714.14 10 172 7 179 ISEGIFGCVFKGWINEnnltaTKPGYGTTVAIKQLT-----------PKEFLGFDKWLHPNLIKLIAYCHEGNNLLLVYEFMPRGSLEDYLFER-GTECLCWATRIKVAAGAARGLSFLHDakNHVTHRYIDPVHILLDEEYNAKLSGLFLADDK-----TYMSTQIVGTYAYAAPEYVV + eG fG V++g +++ +k ++va+K+l+ +e + k hpn++kl++ c ++++ll+v e+++ G+L+++L ++ +e l+ + +++a+ A+G+++L++ +++ Hr + +Ll+e+ +k+s La+d ++++++ + + apE + lGeGafGeVvegtlkg.....ekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLes..kklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslk 65.8 2.4e-20 Protein tyrosine kinase 180 Cluster-8025.0-2R PF00069.22 10 171 7 169 ISEGIFGCVFKGW-INENNLTATKPGYGTTVAIKQ--LTPKEFLGFDKWLHPNLIKLIAYCHEGNNLLLVYEFMPRGSLEDYLFERGTecLCWATRIKVAAGAARGLSFLHdaKNHVTHRYIDPVHILLDEEYNAKLSGLFLADDKTYMS--TQIVGTYAYAAPEYV + eG fG+V+k+ ++++ A K k+ + +E + k hpn+++l+ +++e ++l+lv e+++ g+l+d+l ++g+ l ++ k+a+ ++gl++lH ++++ Hr + p iL+de+ + K++ + la + s t++vgt Y APE + lGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgs..lseeeakkiakqilegleylH..skgiiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtreYlAPEvl 64.5 6.4e-20 Protein kinase domain 180 Cluster-8078.2-2R RLK-Pelle_RLCK-V 190 456 1 267 ENIIGEGGYGIVYRGQLVNGTFVAVKKLLNNLGQAEKEFRVEVDAIGHVRHKNLVRLLGYCIEGTHRALVYEYVNNGNLEQWLHGAMAHHGYLSWEARMKILLGTAKALAYLHEAIEPKVVHRDIKSSNILIDEDFNAKISDFGLAKMLGAGKSHITTRVMGTFGYVAPEYANSGLLNEKSDVYSFGVVLLEAITGRDPVDYSRPAPEVNMVDWLKMMVGARRSEEVVDPKIETRPSTSALKRALLTALRCVDPDSDKRPAMSQVVR en+igeGgyg+vyrg+l++gt vavkkllnn gqaekef+vev+aig+vrhknlvrllGyc+eg++r lvyeyv+ngnleqwlhG++ ++++l+wearmki+lgtakalaylhea+epkvvhrdikssnil+d++fnak+sdfGlak+lg++ks++ttrvmgtfgyvapeyan+gllneksdvysfgv+lle+itgrdpvdysrpa evn+v+wlk+mv+ rr+eevvdpk+e++ps++alkrall+alrcvdpd++krp m+qvv+ envigeGgygvvyrgkladgtevavkkllnnkgqaekefkveveaigkvrhknlvrllGycvegaerllvyeyvdngnleqwlhGdvseksaltwearmkiilgtakalaylhealepkvvhrdikssnilldkefnakvsdfGlakllgseksyvttrvmgtfgyvapeyantgllneksdvysfgvllleiitgrdpvdysrpaeevnlvewlklmvaerraeevvdpkleekpssralkrallvalrcvdpdaekrpkmgqvvk 515.4 1.8e-157 RLK-Pelle_RLCK-V 580 Cluster-8078.2-2R PF00069.22 188 456 2 260 SRENIIGEGGYGIVYRGQ-LVNGTFVAVKKLLNNLGQAEKE--FRVEVDAIGHVRHKNLVRLLGYCIEGTHRALVYEYVNNGNLEQWLHgamaHHGYLSWEARMKILLGTAKALAYLHEAIepkVVHRDIKSSNILIDEDFNAKISDFGLAKMLGAGKShiTTRVMGTFGYVAPEYANSGLLNEKSDVYSFGVVLLEAITGRDPVDYSRPAP-EVNMVDWLKMMVGARRseeVVDPKIETRPSTSALKRALLTalRCVDPDSDKRPAMSQVVR ++++ +GeG++G Vy++ +g vAvKk+ ++ + +ke ++ E+ + +++h+n+vrl++++ e +++ lv eyv++g+l+++l+ ++g ls e ki+ ++++l+ylH++ ++HrD+K++NiLide+ + Ki+DFGlak l +++ +t ++gt Y+APE ++ +k+Dv+s Gv+l+e +tg+ p ++ +++d l++++ + ++ k+++ + s + ll+ ++++ d kR+ ++++++ ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls....rkgslseeeakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg...etkeklpeaselseeakdllk..kllkkdpkkRltaeellq 166.5 4.8e-51 Protein kinase domain 580 Cluster-8078.2-2R PF07714.14 190 458 4 260 ENIIGEGGYGIVYRGQLV-----NGTFVAVKKLLNNLGQA-EKEFRVEVDAIGHVRHKNLVRLLGYCIEGTHRALVYEYVNNGNLEQWLHGAmAHHGYLSWEARMKILLGTAKALAYLHEAiepKVVHRDIKSSNILIDEDFNAKISDFGLAKML-GAGKSHITTRVMGTFGYVAPEYANSGLLNEKSDVYSFGVVLLEAIT-GRDPvdysrpapevnmvdwLKMMVGARRSEEVVDPKIETRPStSALKRALLTALRCVDPDSDKRPAMSQVVRML ++ +GeG +G V++g+l + + vavK+l ++ + ++ef e++ + +++h+n+v+llg c+++ + +v eyv++G+L++ L+ ++ l+ + +++ l Ak+++yL++ k+vHrd+ + N+L++e+ +kisDfGLa+ + + + +++ + ++apE +++ +++ksDv+sfGv+l E +t g++p ++ + ++ e + + k ++p+ ++ ++ +C++ d+++Rp ++++v+ l gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk.eekekltlkdllsfalqiAkGmeyLesk...klvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep...............ypglsneevleklkegkrlekpe.kcpeelyelmkqCweedpeeRptfkelvekl 151.6 1.6e-46 Protein tyrosine kinase 580 Cluster-8185.0-2R AGC_MAST 2 105 189 292 NRSAVGTPDYLAPEILLGTGHGFTADWWSVGIILFELIVGIPPFNAEHPQKIFDNILNRNIPWPRVPEEMSHEAHDLIDQLLTEDPNQRLGARGASEVKHHPFF +rsavgtpdylapeillgt+hg +adwwsvg+ilfel+vgippfnae+pqkifdnilnr+ipwp+vpee+s+ea+dlid+lltedp++rlga+ga+evk+h+ff krsavgtpdylapeillgtshgaaadwwsvgvilfellvgippfnaekpqkifdnilnrkipwpevpeelsleaqdlidklltedpekrlgakgaaevkahkff 202.2 7.3e-62 AGC_MAST 338 Cluster-8185.0-2R PF00069.22 3 105 155 264 RSAVGTPDYLAPEILLGTGHGFTADWWSVGIILFELIVGIPPFNAEHPQKIFDNILNR----------NIPWPRVPEEMSHEAHDLIDQLLTEDPNQRLGargASEVKHHPFF +s vgt++YlAPE+l +++++ ++D+Ws+G+il+el+ g ppf++e+ ++ + ++l++ + ++++e+s+ea dl+++ll++dp++Rl+ a+e+++hp++ tsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRlt...aeellqhpyl 77.2 8.6e-24 Protein kinase domain 338 Cluster-8185.0-2R PF07714.14 8 91 169 251 TPDYLAPEILLGTGHGFTADWWSVGIILFELIV-GIPPFNAEHPQKIFDNIlNRNIPwPRVPEEMSHEAHDLIDQLLTEDPNQRL ++apE+l + +D Ws G++l+E++ g p++ +++++++++ +++ + pe++++e ++l+ q ++edp++R pvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevlekl.kegkr.lekpekcpeelyelmkqCweedpeeRp 27.4 1.2e-08 Protein tyrosine kinase 338 Cluster-821.0-0R AGC_NDR 10 115 152 257 KLAFSTVGTPDYIAPEVLLKKGYGMECDWWSLGAIMYEMLIGYPPFYSDDPMTTCRKIVHWKHHLRFPEDAKLSPEAKDLICRLLCDVEHRLGTGGAGQIKAHPWF kla+stvgtpdyiapevllkkgygmecdwwslgai+yeml+gyppfysddp+ttcrkiv+w+++l+fp++akls+eakdli+rllcdve+rlgt ga +ikahpwf klaystvgtpdyiapevllkkgygmecdwwslgailyemlvgyppfysddplttcrkivnwrtllkfpdeaklskeakdlisrllcdvekrlgtkgaeeikahpwf 208.2 9.5e-64 AGC_NDR 182 Cluster-821.0-0R PF00069.22 7 115 149 264 NRRKLAFSTVGTPDYIAPEVLLKKGYGMECDWWSLGAIMYEMLIGYPPFYSDDPMTTCRK----------IVHwKHHLRFPEDAKLSPEAKDLICRLLC-DVEHRLGtggAGQIKAHPWF ++++ + s vgt++Y+APEvl +++y+ ++D+WslG i+ye+l g ppf++++ ++ +k i++ + ++ +pe+ +ls+eakdl+ +ll+ d ++Rl+ a ++++hp++ essskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.etkeklpeaselseeakdllkkllkkdpkkRlt...aeellqhpyl 76.5 1.4e-23 Protein kinase domain 182 Cluster-821.0-0R PF07714.14 18 90 169 239 TPDYIAPEVLLKKGYGMECDWWSLGAIMYEMLI-GYPPFYSDDPMTTCRKIvhwKHHLRFPEDAKLSPEAKDLI ++apE+l +k + + D Ws G +++E++ g p+ + +++++++k+ k++ r ++ +k ++e ++l+ pvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevlekl...kegkrlekpekcpeelyelm 25.0 6.7e-08 Protein tyrosine kinase 182 Cluster-8234.0-0R AGC_NDR 101 211 43 153 VEHVKAERNLLAEVDSSCIVKLYCSFQDEEYLYLIMEYLPGGDMMTLLMRKDTLTDYEAKFYAAEAVLAIESIHKHNYIHRDIKPDNLLLDRYGHLKLSDFGLCKPLDCSI vehvkaernllaevds++ivkly+sfqdeeylylimeylpggd+mtllmrkdtlt+ ea+fy ae+vlaiesihkhnyihrdikpdnllld++ghlklsdfglckpld+++ vehvkaernllaevdselivklyysfqdeeylylimeylpggdlmtllmrkdtltedearfyvaesvlaiesihkhnyihrdikpdnllldkeghlklsdfglckpldakl 230.5 1.5e-70 AGC_NDR 251 Cluster-8234.0-0R PF00069.22 102 208 43 149 EHVKAERNLLAEVDSSCIVKLYCSFQDEEYLYLIMEYLPGGDMMTLLMRKDTLTDYEAKFYAAEAVLAIESIHKHNYIHRDIKPDNLLLDRYGHLKLSDFGLCKPLD ++v +E ++l++++++ iv+ly +f+++++lyl++ey++gg++++ll rk +l++ eak++a++ + ++e +H+++ iHrD+Kp+N+L+d+ g+lK++DFGl+k l+ kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakele 103.4 8.6e-32 Protein kinase domain 251 Cluster-8234.0-0R PF07714.14 104 207 48 154 VKAERNLLAEVDSSCIVKLYCSFQDEEYLYLIMEYLPGGDMMTLLMRK---DTLTDYEAKFYAAEAVLAIESIHKHNYIHRDIKPDNLLLDRYGHLKLSDFGLCKPL + e +++ +++ ivkl+ +ee l++++ey++gGd+ + L +k ++lt + +a++ ++e +++++++Hrd+ N Ll++ + k+sDfGL++ + fleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardi 59.3 2.2e-18 Protein tyrosine kinase 251 Cluster-8242.0-1F CAMK_CAMKL-CHK1 35 289 1 256 YELGKLLGQGTFAKVHHARNLKTGMSVAIKIIDKEKILKVGMIDQIKREISVMRLVRHPNIVQLYEVMATKTKIFFVMEYVKGGELFNKVAK-GKTKEEVARKYFQQLISAVDFCHSRGVYHRDLKPENLLLDENGNLKVSDFGLSALAESKRQDGLLHTTCGTPAYVAPEVINRRGYDGAKADIWSCGVILYVLLAGYLPFHDPNLMEMYRKIGKGEFKCPNWVPPDARRLISRILDPNPKTRISISKIMENSWF yelG+llG+gtfakv++ar+l+tg svaik++dkek+lk ++++qikreisv++lvrhpn+v+l+ev+atk+ki++v+eyvkGGelf+k+ak g+ ke+ arkyfqqlisavd+chsrgvyhrdlkpenlllde+gnlkvsdfGlsalae++r+dgllhttcGtPayvaPev++++gydgakad+WscGvil+vllagylPf+d nl+e+yrki k+efk+p+w+ ++a++lisr+ldpnp+tri+i++i+e++Wf yelGrllGegtfakvklardletgesvaikvldkekvlkaklveqikreisvlklvrhpnvvrllevlatkskiylvleyvkGGelfekiakkgrlkedearkyfqqlisavdychsrgvyhrdlkpenllldekgnlkvsdfGlsalaeqlredgllhttcGtPayvaPevlkkkgydgakadvWscGvilfvllagylPfedenlvelyrkilkaefklpkwlskeakklisrlldpnpetritieeileeeWf 464.5 6.6e-142 CAMK_CAMKL-CHK1 535 Cluster-8242.0-1F PF00069.22 35 289 1 264 YELGKLLGQGTFAKVHHARNLKTGMSVAIKIIDKEKILKVGMiDQIKREISVMRLVRHPNIVQLYEVMATKTKIFFVMEYVKGGELFNKVA-KGKTKEEVARKYFQQLISAVDFCHSRGVYHRDLKPENLLLDENGNLKVSDFGLSALAESKRQdglLHTTCGTPAYVAPEVINRRGYdGAKADIWSCGVILYVLLAGYLPFHDPNLME----MYRK-------IGK--GEFKCPNWVPPDARRLISRILDPNPKTRISISKIMENSWF ye + lG+G+f+kV a++ +tg vA+K+i+kek+ k +++ rEi++++ ++hpniv+lyev+ +k+++++v+eyv+ggel++ + kg+ +ee a+k+++q++++++++Hs+g+ HrDlKpeN+L+de+g+lK++DFGl++ +es+ + l++ +gt+ Y+APEv+++++y ++k+D+Ws+Gvily ll+g pf++ + e ++++ +g+ +++ ++ ++++a++l++++l+ +pk+R++++++++++++ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeney.skkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 251.7 4.9e-77 Protein kinase domain 535 Cluster-8242.0-1F PF07714.14 36 285 2 258 ELGKLLGQGTFAKVHHARNL----KTGMSVAIKIIDKEKILKVgmIDQIKREISVMRLVRHPNIVQLYEVMATKTKIFFVMEYVKGGELFNKVAKG----KTKEEVARKYFQQLISAVDFCHSRGVYHRDLKPENLLLDENGNLKVSDFGLSALAESKRQDGLLHTTCGTPAYVAPEVINRRGYDgAKADIWSCGVILYVLLA-GYLPFHDPNLMEMYRKIGKGE-FKCPNWVPPDARRLISRILDPNPKTRISISKIME elgk lG+G+f++V++++ k+ ++va+K++++e+ + +++ +e+++m+ ++hpniv+l+ v+ + ++++v+eyv+gG+L + + k k++ + ++ +q+ +++++ +s+ + Hrdl N Ll+en k+sDfGL+ e++ + +++ ++apE+++++ + k+D+Ws Gv+l+ ++ g p+++ + +e+++k+ +g+ ++p+ +p++ +l+++ ++ +p+ R ++++++e elgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateee..keefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkft.sksDvWsfGvllwEiftlgeepypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelve 140.7 3.3e-43 Protein tyrosine kinase 535 Cluster-8278.0-2F CAMK_CDPK 109 179 1 71 YTLGRKLGQGQFGTTYLATENSTGMEYACKSILKRKLISKEDVEDVRREIQIMHHLAGHTHIVTIKGAYED y+lg++lG+G+fG+++late++tg e+A+Ksi krkl ++edvedvrre++i++hl+gh+++v++kgayed yelgkelGrGefGvvrlatekatgeevAvKsiskrklskaedvedvrrevkilkhlsghknvvqlkgayed 88.0 5.9e-27 CAMK_CDPK 180 Cluster-8278.0-2F PF00069.22 109 179 1 69 YTLGRKLGQGQFGTTYLATENSTGMEYACKSILKRKLISKEDvEDVRREIQIMHHLAgHTHIVTIKGAYED y+ +klG+G+fG+ y a+e++tg ++A+K i k+k +k++ ++v+rEi+i+++l h +iv++++++e+ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklk.hpnivrlyevfee 52.5 2.9e-16 Protein kinase domain 180 Cluster-8278.0-2F PF07714.14 110 177 2 70 TLGRKLGQGQFGTTYLATEN----STGMEYACKSIlkRKLISKEDVEDVRREIQIMHHLaGHTHIVTIKGAY +lg+klG+G+fG+ + +t + ++ ++ a K++ ++ ++e+ e++ +e++im++l h +iv + g++ elgkklGeGafGeVvegtlkgekekkevkvavKtl..keeateeekeefleeakimkkl.khpnivkllgvc 30.4 1.5e-09 Protein tyrosine kinase 180 Cluster-8280.0-2F RLK-Pelle_LRR-XI-1 1 159 107 266 KGLEYLHHGCDRPIIHRDVKSSNILLDELLKPRIADFGLAKIAQ-FNSTESTQVIAGTHGYIAPEYGYTRKVNEKSDLYSFGVVLMELVTGKRPIEGEYGENKDIVDWVCSKlkTKESVLSIVDKAV--PEAYKEDAIKVLKIGIMCTARLPSLRPTMRHVV +gL+Ylhh+c++pi+HrDvkssniLLd+ +++++adfglak+ + +++es++++ag++GYiaPey+yt kv+eksD+YSfGvvl+elvtgk+p++ e+ge++div+wv +k +ke+v +i+D+++ ea++e+++kvlk++++ct++ p+ RPtmr+vv egLaYlhhdcsppivHrDvkssniLLdsefeakvadfglakvldekkeseslsavagsyGYiaPeyaytlkvteksDvYSfGvvlLelvtgkkpvdeefgesvdivkwvaek..kkekveeilDeklavseaaeeemlkvlkvallctsespeeRPtmrevv 214.6 1.1e-65 RLK-Pelle_LRR-XI-1 204 Cluster-8280.0-2F PF00069.22 1 160 109 260 KGLEYLHHGCdrpIIHRDVKSSNILLDELLKPRIADFGLAKIAQFNSTesTQVIAGTHGYIAPEYGYTRKVNEKSDLYSFGVVLMELVTGKRPIEGEYGENKDIVdwVCSKLKTKESVLSIVDKAV--PEAYKEDAIKVLKigiMCTARLPSLRPTMRHVVQ +gleylH+ + iiHrD+K++NiL+de + +i+DFGlak ++ +s+ ++ + gt+ Y+APE ++++ +k+D++s Gv+l+el+tgk p +ge g++k + +l++ +l +++++ ++ +e+a+++lk + ++ p+ R+t+++++q egleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvek..eldqlekilkilgetkeklpeaselseeakdllk...kllkkdpkkRltaeellq 99.3 1.5e-30 Protein kinase domain 204 Cluster-8280.0-2F PF07714.14 1 162 115 260 KGLEYLHhgcDRPIIHRDVKSSNILLDELLKPRIADFGLAKIA-QFNSTESTQVIAGTHGYIAPEYGYTRKVNEKSDLYSFGVVLMELVT-GKRPiegeygenkdivdwvCSKLKTKESVLSIVDKAVPEAYKEDAIKVLKIGIMCTARLPSLRPTMRHVVQML kG+eyL+ ++ ++Hrd+ + N+Ll+e + +i+DfGLa+ + +++++++ ++apE ++k+++ksD +sfGv+l+E++t g++p ++l+++e + + ++ e+ ++ ++ ++ C ++ p+ Rpt++++v+ l kGmeyLe...skklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep...............ypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 77.7 5.6e-24 Protein tyrosine kinase 204 Cluster-8317.0-2F CK1_CK1 120 355 1 236 FKLGRKIGSGSFGELYLGANIQTGEEVAVKLESVKTKHPQLRYESKLYMLLQGGTGIPHLKWFGVEGEYNAMVIDLLGPSLEDLFNYCNRKFSLKTVLMLADQLINRVEYMHSRGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKYRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLRAGTKKQKYDKISEKKMLTPIELLCKSY fklgrkigsgsfge+ylg+n+qt eeva+klesvktkhpql yeskly++lqggtgip+lkwfgveg+yn++v+dllgpsledlfnyc+rkfslktvlmladqlinrvey+hs+gflhrdikpdnflmglgrkanqvyiid+glakkyrd +t+khipyrenknltgtaryasvnthlg+eqsrrddleslgyvl+yflrgslpwqgl+agtkkqky+kisekk+ t+ie lcksy fklgrkigsgsfgeiylgtnvqtneevaiklesvktkhpqllyesklyrilqggtgipnlkwfgvegdynvlvldllgpsledlfnycsrkfslktvlmladqlinrveyvhskgflhrdikpdnflmglgrkanqvyiidfglakkyrdaktkkhipyrenknltgtaryasvnthlgieqsrrddleslgyvllyflrgslpwqglkagtkkqkyekisekkvstsievlcksy 481.4 3.2e-147 CK1_CK1 628 Cluster-8317.0-2F PF00069.22 121 338 2 212 KLGRKIGSGSFGELYLGANIQTGEEVAVKLESVKTKHP----QLRYESKLYMLLQgGTGIPHLKWFGVEGEYNAMVIDLLGP-SLEDLFNyCNRKFSLKTVLMLADQLINRVEYMHSRGFLHRDIKPDNFLMGlgrKANQVYIIDYGLAKKYRDLQThkhipyreNKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLRA-GTKKQKYDK + +k+G+GsfG+ y + + +tg++vAvK +++ + +++ E k+ l+ i +l+ + e ++ +v++++ +l+dl + + ++s +++ +a q+++ +ey+Hs+g++HrD+Kp+N+L+ + +++ i+D+Glak+++ ++ ++ +gt +Y + + e s+ D+ slG +l+ +l g p++g + ++++++d+ ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklk.hpnivrlyevfeekdelylvleyveggeladlls.rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLid...ekgelKitDFGlakelesssk........ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldq 90.6 6.7e-28 Protein kinase domain 628 Cluster-8317.0-2F PF07714.14 121 381 2 257 KLGRKIGSGSFGELYLGANI----QTGEEVAVKLESVKTKHP---QLRYESKLYMLLqGGTGIPHLKWFGVEGEYNAMVIDLLG-PSLEDLFNYC--NRKFSLKTVLMLADQLINRVEYMHSRGFLHRDIKPDNFLMGlgrKANQVYIIDYGLAKKYRDLQTHkhipyRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLR-GSLPWQGLragTKKQKYDKISEKKMLTPIellcKSYPSEFISYFHYCRSLQFEDKPDYSYLK +lg+k+G+G+fGe + g ++ +vavK + ++++ ++ e k+ + l i +l + +++e +v++++ +L++ + ++k++lk++l +a q+ + +ey++s+ ++Hrd+ N L+ + ++v i D+GLa++ ++ ++ +++++ + ++ ++ + + + + D s G +l+ + g+ p++gl ++++ ++k++e+k l+ ++ p+e+ + + C + + e+ p+++ l elgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkkl.khpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLls...enkvvkisDfGLardiekddey.....kkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypgl...sneevleklkegkrlekp....ekcpeelyelmkqCweedpeeRptfkelv 50.7 9.6e-16 Protein tyrosine kinase 628 Cluster-8363.0-0R CMGC_MAPK 2 159 63 221 IKDIIRPPKKDAFSDVYIVYELMDTDLHQIIRSDQPLTDDHCQYFLYQLLRGLRYIHSANVLHRDLKPSNLFLNANCDLKIGDFGLART-TSETDFMTEYVVTRWYRAPELLLNCSEYTAAIDVWSVGCILVEILTREPLFPGKDYVHQLKLITELLGT +kd+++p++k+ f+Dvyiv+elmdtdlhq+i+s++ lt++h+qy+lyqllrgl+y+hsanvlhrDlkp+nl+lnanc+lki DfGlar+ +setd++teyvvtrwyraPelll++s+Yt+aiDvWsvGCi++e+ltr+plfpgkd+v+qlklitel+Gt lkdvlkpaekeefkDvyivlelmdtdlhqviksndelteehvqyllyqllrglkylhsanvlhrDlkpknlllnancklkicDfGlarsassetdllteyvvtrwyraPelllssskYtsaiDvWsvGCifaelltrkplfpgkdvvdqlkliteliGt 288.1 5.3e-88 CMGC_MAPK 159 Cluster-8363.0-0R PF00069.22 15 152 71 215 SDVYIVYELMDTD-LHQIIRSDQPLTDDHCQYFLYQLLRGLRYIHSANVLHRDLKPSNLFLNANCDLKIGDFGLARTTSETDFMTEYVVTRWYRAPELLlNCSEYTAAIDVWSVGCILVEILTREPLFP---GKD----YVHQLKL +++y+v e+++++ l+++++ ++ l++++++ +++q+l+gl+y+Hs++++HrDlKp+N++++ + +lKi+DFGla+ +++ +t++v+tr+Y+APE+l + +ey++++DvWs+G+il+e+lt++p+f+ gk+ ++ql+ delylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtreYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlek 158.1 1.8e-48 Protein kinase domain 159 Cluster-8363.0-0R PF07714.14 16 137 75 202 DVYIVYELMDT-DLHQIIRSD---QPLTDDHCQYFLYQLLRGLRYIHSANVLHRDLKPSNLFLNANCDLKIGDFGLARTT----SETDFMTEYVVTRWYrAPELLLNCSeYTAAIDVWSVGCILVEILTR ++iv e+++ dL++ +r++ ++lt ++ f +q+ +G++y++s +++Hrdl N +l+ n ki+DfGLar++ + ++ ++ + +W+ apE l +++ +t + DvWs G +l Ei+t+ pllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWm.apEslkekk.ftsksDvWsfGvllwEiftl 81.1 5.1e-25 Protein tyrosine kinase 159 Cluster-839.0-1R TKL_CTR1-DRK-2 105 267 1 163 LQIGERIGIGSYGEVYRAEWNGTEVAVKKFMNQDISGVALAQFRCEVEIMLRLRHPNVVLFMGAVTRPPNLSILTEFLPRGSLFKLLHRLNVQIDEKRRIKMALDVARGMNYLHTSHPIIVHRDLKTPNLLVDKNWVVKVCDFGMSRLQHNTFLSSKSTAGTA l+igeriG Gs+gevyraew+G++vavk+f++qd+s al++fr ev++m rlrhpnvvlfmGavt+p++lsi+teflprgslf+ll+r + ++de+rr+k+aldvarG+nylh+++p+ivhrdlk++nllvdknw+vkv+dfG+srl+++tflsskstaGt+ ltigeriGqGsfgevyraewkGsdvavkvflkqdlseealeefrkevslmkrlrhpnvvlfmGavtkpqrlsivteflprgslfrllerkksklderrrlklaldvarGlnylhklsppivhrdlkssnllvdknwtvkvadfGlsrlkaetflsskstaGtp 284.7 5.7e-87 TKL_CTR1-DRK-2 267 Cluster-839.0-1R PF07714.14 105 255 1 156 LQIGERIGIGSYGEVYRAEWN------GTEVAVKKFmNQDISGVALAQFRCEVEIMLRLRHPNVVLFMGAVTRPPNLSILTEFLPRGSLFKLLHRL--NVQIDEKRRIKMALDVARGMNYLHTSHpiIVHRDLKTPNLLVDKNWVVKVCDFGMSRLQHN l++g+++G G++GeV++++++ ++vavK++ +++ + + ++f e++im +l+hpn+v ++g++t+ +l i+te+++ G+L k L++ + +++ k+ +++al++A+Gm+yL+ + +vHrdl + N L+++n vvk++DfG++r ++ lelgkklGeGafGeVvegtlkgekekkevkvavKtl.keeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskk..lvHrdlaarNvLlsenkvvkisDfGLardiek 128.0 2.4e-39 Protein tyrosine kinase 267 Cluster-839.0-1R PF00069.22 107 256 3 151 IGERIGIGSYGEVYRAE--WNGTEVAVKKFMNQDISGVALAQFRCEVEIMLRLRHPNVVLFMGAVTRPPNLSILTEFLPRGSLFKLLHrLNVQIDEKRRIKMALDVARGMNYLHTSHpiIVHRDLKTPNLLVDKNWVVKVCDFGMSRLQHNT e++G Gs+G+Vy+a ++g +vAvKk+ +++++ +++ E++i+ +l+hpn+v ++++++++ +l +++e+++ g+l++ll+ +++++e++ k+a +++g++ylH + i+HrDlK+ N+L+d++ ++K++DFG+++ +++ kleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls.rkgslseeeakkiakqilegleylHskg..iiHrDlKpeNiLidekgelKitDFGlakeless 123.8 5e-38 Protein kinase domain 267 Cluster-8409.0-1R RLK-Pelle_SD-2b 284 550 2 267 HLLGTGGFGSVYKGTLRDGALIAVKKLDRVlSHGEKEFITEVNTISSMHHVNLVRLCGYCSEGSQRLLVYEFMKNGSLDKWIFpsHNSRERLLDWSTRFLVALGTAQGIAYFHEQCRDRIIHCDIKPENILLDENFCPKVSDFGLAKLMGREHSHVVTMVRGTRGYLAPEWVSNRPITVKADVYSYGMLLLEIIGGRRNLDM--TFDSEGFFYPGWAFKELANGAPTKVADRRLEGAVEEEELVRALKVAFWCIQDEISMRPTMGEVVK + lG+GgfgsVykg+l+d+ +avKkl++v ++gekef +ev++i+s++hvnLvrl+G+cseg++rllvye+++ngsLdk++f +++++++l+w+tr+ +alg+A+g+ay+He+cr++iihcdikpeniLlde+f+pk++dfGlakl++r++s+v+t vrGtrgYlapew+sn++it k+DvYsyG++lle++ grrn+++ + ++e ++++ +a+++l +g +++ d+rleg+v++ee+ r++kva+wciq++ s+RP+m evvk eklGeGgfgsVykgvledetkvavKklekv.eqgekefraevsvigsiqhvnLvrllGfcsegekrllvyeyvengsLdkllf..kkkskkvlewktrlkialgvArglayLHeecrekiihcdikpeniLldekfepkiadfGlakllkrdqsrvlttvrGtrgYlapewisnlaitekvDvYsyGvvllelvsgrrnveekeseeeesvllvklaaekleegevaelvdarlegevdleevervvkvalwciqedeskRPsmsevvk 387.7 1.9e-118 RLK-Pelle_SD-2b 655 Cluster-8409.0-1R PF00069.22 283 484 4 198 SHLLGTGGFGSVYKGT-LRDGALIAVKKLDRVLSHGEKE--FITEVNTISSMHHVNLVRLCGYCSEGSQRLLVYEFMKNGSLDKWIFpshnsRERLLDWSTRFLVALGTAQGIAYFHEQCrdrIIHCDIKPENILLDENFCPKVSDFGLAKLMGREHShvVTMVRGTRGYLAPEWVSNRPITVKADVYSYGMLLLEIIGGRRNLD + lG+G+fG+Vyk++ ++g +AvKk+++ +ke +++E++ + +++h n+vrl ++++e ++++lv e++++g+l++++ r+ l+ ++ +a +++g++y H+++ iiH+D+KpeNiL+de+ K++DFGlak + ++++ +t + gtr YlAPE++++++++ k+Dv+s+G++l+e++ g+ + leklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls.....rkgslseeeakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfs 156.7 4.7e-48 Protein kinase domain 655 Cluster-8409.0-1R PF07714.14 282 551 3 259 FSHLLGTGGFGSVYKGTLR-----DGALIAVKKLDRVLSHG-EKEFITEVNTISSMHHVNLVRLCGYCSEGSQRLLVYEFMKNGSLDKWIfpSHNSRERLLDWSTRFLVALGTAQGIAYFHEQcrdRIIHCDIKPENILLDENFCPKVSDFGLAKLM-GREHSHVVTMVRGTRGYLAPEWVSNRPITVKADVYSYGMLLLEIIG-GRRNldmtfdsegffYPGWAFKELANGAptkvaDRRLEGAVEEEELVRALKVAFWCIQDEISMRPTMGEVVKM +++ lG G fG+V++gtl+ + +avK+l++ ++ ++ef++e++++++++h n+v+l g c+++++ l+v e++++G+L+k + ++++++ l+ ++ + +al A+G++y +++ +++H d+ N+Ll+en + k+sDfGLa+ + +++ ++ + + ++apE ++++ +t+k+Dv+s+G+ll Ei+ g++ ypg+ +e+++ +++ + + e+ + ++ C++ + + Rpt+ e+v+ lgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfL..rkkeekekltlkdllsfalqiAkGmeyLesk...klvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep...........ypglsneevlekl.....kegkrlekpekcpeelyelmkqCweedpeeRptfkelvek 136.4 6.8e-42 Protein tyrosine kinase 655 Cluster-8465.0-0F RLK-Pelle_LRR-VII-1 4 146 22 164 IMAIKKLVTTNTLQCQEEFDREVWVLAKVRHPNVMPLRGYYWTPQMQLLVSDYALEGSLQSRLHERGPTSPPLSWPTRFKIVLGTAKGLAHLHHSFRPSIVHYNVKPSNILLDKNLNPMISDFGLARLLTKLDKHDLSNRFQS +a+kkL +++ ++ qeef+rev L+k+rh+n++ l+Gyyw++++qLl+s++ +gsL+++Lher ++++lsW +rfki+lg+a+gLa+Lhh++rp+++h+n+k++nilld++l++++sd+Gla+lL+ ldk+ ls+++qs svavkkLevlslvksqeeferevkkLgklrhknlvtlkGyywssslqLllsefvangsLykkLherseaetslsWeerfkialgvargLayLhhdlrpqvlhlnlkstnilldeeleakvsdyGlaklLpvldkyvlsskvqs 199.2 6.6e-61 RLK-Pelle_LRR-VII-1 146 Cluster-8465.0-0F PF00069.22 2 135 24 151 QRIMAIKKLVTTNTLQCQE-EFDREVWVLAKVRHPNVMPLRGYYWTPQMQLLVSDYALEGSLQSRLHERGPTSPPlswpTRFKIVLGTAKGLAHLHHSFrpsIVHYNVKPSNILLDKNLNPMISDFGLARLLTKL ++i+A+Kk+ + ++ + +e ++ rE+ +l+k++hpn++ l +++ +++ +lv +y+ +g+l+++l+++g s+ + ki+ +++gl++lH+ i+H +Kp+NiL+d++ + +i+DFGla+ l++ gkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslsee....eakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakeless 81.3 4.6e-25 Protein kinase domain 146 Cluster-8465.0-0F PF07714.14 4 137 30 159 IMAIKKLVTTNTLQCQEEFDREVWVLAKVRHPNVMPLRGYYWTPQMQLLVSDYALEGSLQSRLHERgPTSPPLSWPTRFKIVLGTAKGLAHLHHSfrpSIVHYNVKPSNILLDKNLNPMISDFGLARLLTKLDK a+K+l ++t + +eef +e+ ++ k++hpn++ l g + + l+v +y+ +G+L++ L+++ ++++l+ + ++++l AkG+++L++ ++vH ++ N+Ll++n isDfGLar ++k d+ kvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk.eekekltlkdllsfalqiAkGmeyLesk...klvHrdlaarNvLlsenkvvkisDfGLardiekdde 71.4 4.7e-22 Protein tyrosine kinase 146 Cluster-8465.2-0F RLK-Pelle_LRR-VII-1 1 107 162 268 FQSAPGYMAPELACQSLRVNEKCDVYCFGVLILELVTGRRPVEYGEDNVVILADHVRALLEQGNALDCVDPSMGNYAEDEVLPVLKLALVCTSQIPSSRPSMAEVVQ +qsa gy+aPelac+slrv+ekcdvy fGv++LelvtGr+pve+ ed+vv+lad+vr+lle+G++ +cvd+++ ++ e+ev++vlklalvcts++ps+rpsmaevvq vqsalgyvaPelackslrvtekcdvysfGvvlLelvtGrkpvesaeddvvvladlvrelleeGkvsecvdrklkefeeeevvqvlklalvctsevpskrpsmaevvq 173.4 4.8e-53 RLK-Pelle_LRR-VII-1 159 Cluster-8465.2-0F PF00069.22 4 107 160 260 APGYMAPELAcQSLRVNEKCDVYCFGVLILELVTGRRPVEYGEDNV--VILADH---VRALLEqgnaldCVDPS------MgnyaedeVLPVLKLALVCTSQIPSSRPSMAEVVQ + Y+APE+ ++ ++ +k+Dv+ Gv+++el+tg+ p + +++ +d+ ++ +l+ +++ + + +++l + ++ p++R++++e++q treYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg......etkeklpeasel.......seeakdllkkllkkdpkkRltaeellq 32.8 3e-10 Protein kinase domain 159 Cluster-8465.2-0F PF07714.14 6 109 171 260 GYMAPELACQSLrVNEKCDVYCFGVLILELVT-GRRPVEYGEDNVviladhVRALLEQGNALDCVDpsmgnYAEDEVLPVLKlalVCTSQIPSSRPSMAEVVQIL +mapE ++ +++k Dv++fGvl+ E++t g++p++ +++ v + l++g+ l++ + ++++e+ ++k C ++ p++Rp+++e+v+ l kWmapEslkekk.ftsksDvWsfGvllwEiftlgeepypglsnee......vleklkegkrlekpe.....kcpeelyelmk...qCweedpeeRptfkelvekl 29.9 2.1e-09 Protein tyrosine kinase 159 Cluster-8469.0-1R CMGC_MAPK 141 268 1 128 YKILEIIGKGSYGVVCAAVDTHTGEKVAIKKITDIFEHISDAIRILREIKLLRLLRHPDIVEIKRIMVPPSRREFRDIYVVFELMESDLHQVIKANDDLTHEHHRFFLYQMLRALKYMHTANVYHRDL yk+ e iGkGsygvvc+avdt+tgekvaikki+d+fe+ +da r+lreikllr l+h++ive+k ++ p++++ef+D+y+v+elm++dlhqvik+nd+lt+eh++++lyq+lr+lky+h+anv+hrDl ykleeviGkGsygvvcsavdtetgekvaikkiedvfenlidakrvlreikllrrlehenivelkdvlkpaekeefkDvyivlelmdtdlhqviksndelteehvqyllyqllrglkylhsanvlhrDl 206.3 4.6e-63 CMGC_MAPK 268 Cluster-8469.0-1R PF00069.22 141 268 1 124 YKILEIIGKGSYGVVCAAVDTHTGEKVAIKKITDIFEHISDAIRILREIKLLRLLRHPDIVEIKRIMVPpsrreFRDIYVVFELMESD-LHQVIKANDDLTHEHHRFFLYQMLRALKYMHTANVYHRDL y+ le +G+Gs+G+V av+++tg++vA+Kki + ++ ++lrEik+l+ l+hp iv++++++ +++y+v+e++e + l+++++++ l++e+ +++++q+l++l+y+H +++ HrDl yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee.....kdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDl 95.8 1.7e-29 Protein kinase domain 268 Cluster-8469.0-1R PF07714.14 143 268 3 130 ILEIIGKGSYGVVCAAVDT----HTGEKVAIKKITDIFEHISdAIRILREIKLLRLLRHPDIVEIKRIMVppsrR--EfrdIYVVFELMES-DLHQVIKAN---DDLTHEHHRFFLYQMLRALKYMHTANVYHRDL + + +G+G++G V+ + + ++ kva+K++++ ++ + ++l+e+k+++ l+hp iv++ +++ + + +++v+e++e+ dL++ ++++ + lt ++ f +q+ ++++y++ ++ Hrdl lgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateee.keefleeakimkklkhpnivkllgvct....keep...llivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdl 53.2 1.7e-16 Protein tyrosine kinase 268 Cluster-8487.0-2F RLK-Pelle_RLCK-VIIa-1 2 114 155 267 THVSTRVMGTYGYCAPEYAMTGQLTLKSDVYSFGVVLLEIITGRKAIDNSKAAEEHNLVAWARPLFKDRRKFSQMADPMLQGQYPSRGLFQALAVAAMCVQEQPNMRPLIADV thvstrvmgtyGycaPeya+tg+lt+ksdvysfGvvlle+itGr+aid+s+++ee+nlvawarpl+kd++kf+++adp+l+g+yp+rgl+qalavaa+c+qe++++rpli+dv thvstrvmgtyGycaPeyaktgkltvksdvysfGvvllelitGrraidesrpkeeqnlvawarpllkdkkkfakladpllkgkyperglyqalavaalclqeeasarplisdv 202.2 7.8e-62 RLK-Pelle_RLCK-VIIa-1 123 Cluster-8487.0-2F PF07714.14 11 116 169 258 TYGYCAPEYAMTGQLTLKSDVYSFGVVLLEIIT-GRKAIDNSKAAEehnlvawarplfkdrrkFSQMADPMLQGQYPSRGLFQALAVAAMCVQEQPNMRPLIADVVT + ++apE +++++t ksDv+sfGv+l Ei+t g++ + + +++e + ++ + + + p+ + + C++e+p+ Rp ++++v+ pvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsnee.................vleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelve 38.1 6.5e-12 Protein tyrosine kinase 123 Cluster-8487.0-2F PF00069.22 6 115 155 259 TRVMGTYGYCAPEYAMTGQLTLKSDVYSFGVVLLEIITGRKAIDNSKAAEEHNLVAWA-RPLFKDRRkFSQMAD-----PmlqgqypsrgLFQALAVAAMCVQEQPNMRPLIADVV t ++gt Y+APE + + + k+Dv+s Gv+l+e++tg+ ++k e+++ + ++k + ++++ +a+ + +++++p+ R+ +++++ tsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.etkeklpeasel..........seeakdllkkllkkdpkkRltaeell 35.3 4.9e-11 Protein kinase domain 123 Cluster-849.1-2R TKL-Pl-5 2 66 82 144 EKGALSPSTAINFALDIARGMAYLHSEPNVIIHRDLKPRNVLLvnSSADHLKVGDFGLSKLIRVQ +kg+lsps+a++faLdiArG+ayLH++p++iiHrdLkp+n+ll ++a++lkv+dFglskl++v+ kkgklspsravkfaLdiArGlayLHekpdpiiHrdLkpknlll..deagelkvadFglskllkvk 93.8 1.1e-28 TKL-Pl-5 67 Cluster-849.1-2R PF00069.22 2 64 91 149 EKGALSPSTAINFALDIARGMAYLHSEPnvIIHRDLKPRNVLLVNSSAdhLKVGDFGLSKLIR +kg+ls+++a ++a i++g++ylHs+ iiHrDlKp N+L+ +++ lK++DFGl+k ++ rkgslseeeakkiakqilegleylHskg..iiHrDlKpeNiLidekge..lKitDFGlakele 59.1 2.8e-18 Protein kinase domain 67 Cluster-849.1-2R PF07714.14 3 63 98 154 KGALSPSTAINFALDIARGMAYLHSEPnvIIHRDLKPRNVLLVNssADHLKVGDFGLSKLI k +l+ ++ ++fal+iA+Gm+yL+s+ ++Hrdl rNvLl + ++ k++DfGL++ i kekltlkdllsfalqiAkGmeyLeskk..lvHrdlaarNvLlse..nkvvkisDfGLardi 54.4 7.1e-17 Protein tyrosine kinase 67 Cluster-8496.0-0R WNK_NRBP 115 191 1 77 NEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFV +e+lGkGa+ktvy+afde+eGievaWnqvk+ d+l+spe+lerly+e++llk+lkhkni+k+y+sWvd+ ++++n++ kevlGkGavktvykafdeveGievaWnqvkiedvlrspeelerlysevrllkelkhkniiklyasWvdekkktvnli 113.1 1.3e-34 WNK_NRBP 191 Cluster-8496.0-0R PF00069.22 115 187 4 74 NEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEdlERLYCEIHLLKTLKHKNIMKFYTSWVDTANRN +e lG+G++ +Vy+a+++ +g +vA ++k + ++ e +++ Ei++lk+lkh+ni+++y ++ ++ ++ leklGeGsfGkVykaveketgkivAvKkikkekakkkke..kkvlrEikilkklkhpnivrlyevfeekdely 29.9 2.3e-09 Protein kinase domain 191 Cluster-852.0-1R STE_STE7 2 164 96 258 EHLLSKICFQVLTGLEYLHSHKIIHRDLKPSNILVNNKMEVKISDFGVSKIMNRTLDPCNSYVGTCAYMSPERFDPDTHgGNYNGYAGDIWSLGLTLLELYMGHFPYLPEGQRPDWATLMCAICFGEPPSLPESA-SENFRDFIGCCLQKDSGKRWSATQLLSH e+ l++++ qvL+gl+yLh++ki+hrd+kPsn+L+n+k evKI+DFgvski++++l++cn++vgt+aYmsPer++++++ g++++ya+DiWslGltlLel++G+fP+lp g+++dwa+Lm+ai+++epp++p++a se+fr+F+ +clqkd+ kR+sa++Ll+h epalaevarqvLkglayLhkrkivhrdikPsnlLinskgevKIaDFgvskilasslaqcntfvgtvaYmsPerieseaa.gesysyaaDiWslGltlLelalGrfPllplgekedwaaLmlaiveeeppeapadafseefrsFvsaclqkdaekRasaeeLleh 258.8 4.6e-79 STE_STE7 164 Cluster-852.0-1R PF00069.22 2 164 97 261 EHLLSKICFQVLTGLEYLHSHKIIHRDLKPSNILVNNKMEVKISDFGVSKIMNRTLDpCNSYVGTCAYMSPERFdpdthGGNYNGYAGDIWSLGLTLLELYMGHFPYL-PEGQRPDWATLMC-----AI--CFGEPPSLPESASENFRDFIGCCLQKDSGKRWSATQLLSH e+ ++ki+ q+l+gleylHs++iiHrDlKp+NiL+++k e+Ki+DFG++k ++++ + +s+vgt Y++PE ++n + + D+WslG++l+el++g+ p+ +g+ ++ l+ i + e +++ se+++d++ +l+kd kR++a++ll+h eeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk.ltsfvgtreYlAPEvl.....keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqh 143.7 4.3e-44 Protein kinase domain 164 Cluster-852.0-1R PF07714.14 5 162 106 257 LSKICFQVLTGLEYLHSHKIIHRDLKPSNILVNNKMEVKISDFGVSKIM--NRTLDPCNSYVGTCAYMSPERFDPDThggnyNGYAGDIWSLGLTLLELYM-GHFPYLPEgqrpDWATLMCAICFGEPPSLPESASENFRDFIGCCLQKDSGKRWSATQLL l ++++q+ G+eyL+s+k++Hrdl N+L+++++ vkisDfG+++ + + + ++ +m+pE ++ + + D+Ws G +l E++ g+ py + ++++ ++ g+ + pe+++e++ +++ C+++d+ +R + ++l+ llsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekk.....ftsksDvWsfGvllwEiftlgeepypgl....sneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelv 85.8 1.9e-26 Protein tyrosine kinase 164 Cluster-8541.0-2F CMGC_GSK 82 364 1 283 AERVVGTGSFGIVYQAKCLETGETVAIKKVLQDRRYKNRELQLMRSMDHPNVISLKHCFFSTTSRDEVFLNLVMDFVPENMYNVLKHFSDSNQRMPLIYVKLYTYQLFRGLAYLHTVAGVCHRDIKPQNVLVDPLTHQVKICDFGSAKALVEGEANISYICSRYYRAPELIFGATEYTTAIDIWSAGCVLAELLLGQPLFPGENAVDQLVEIIKVLGTPTREEIRCMNPSYTDFRFPQIKAHPWHKVFHKRMPPEAIDLASRLLHYSPSLRCTALEACAHPFF aervvgtgsfg+v+qakcletgetvaikkvlqd+ryknrelq+mr +dhpnv++lkh+ffstt++de++lnlv+++vpe +y v+kh+s++nqr+pliyvklytyq++r+lay+h+v gvchrdikpqn+lv+p thq+k+cdfgsak lv+ge+nisyicsryyrapelifgateyttaidiwsagcvlaelllgqplfpge++vdqlveiikvlgtptreei+cmnp yt+f+fpqikahpwhkvf+kr+ppea+dl+srll ysp+lrctalea++hpff aervvgtgsfgvvfqakcletgetvaikkvlqdkryknrelqimrlldhpnvvalkhlffsttekdelylnlvleyvpetvyrvakhysklnqrlpliyvklytyqicralayihkvvgvchrdikpqnllvnpkthqlklcdfgsakvlvkgepnisyicsryyrapelifgateyttaidiwsagcvlaelllgqplfpgesgvdqlveiikvlgtptreeikcmnpnytefkfpqikahpwhkvfkkrlppeavdlvsrllqyspnlrctalealvhpff 592.3 9.7e-181 CMGC_GSK 374 Cluster-8541.0-2F PF00069.22 82 364 3 264 AERVVGTGSFGIVYQAKCLETGETVAIKKVLQDRRYKN------RELQLMRSMDHPNVISLKHCFFSttsrdEVFLNLVMDFVPENM-YNVLKhfsdSNQRMPLIYVKLYTYQLFRGLAYLHtVAGVCHRDIKPQNVLVDpLTHQVKICDFGSAKALVEGEANISYICSRYYRAPELIfGATEYTTAIDIWSAGCVLAELLLGQPLFP---GEN----AVDQLVEIIKVLGtptR--EEIRCMNPSytdfrfpqikahpwhkvfhkrmPPEAIDLASRLLHYSPSLRCTALEACAHPFF ++ +G+GsfG Vy+a+ etg++vA+Kk+ ++++ k+ rE++++++++hpn++ l+++f + + l lv+++v+++ ++l+ ++ ++ +k +++q+++gl+ylH +g++HrD+Kp+N+L+d + ++Ki+DFG ak l +++ s++++r+Y+APE++ +++ey++++D+Ws+G++l+ell g+p+f+ g++ +dql++i+k+lg e+++ + ++ea+dl ++ll++ p+ R+ta e+++hp++ kleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee.....kdelylvleyveggeladlls....rkgslseeeakkiakqilegleylH.skgiiHrDlKpeNiLid.ekgelKitDFGlakelessskltsfvgtreYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg...etkeklpeasel......................seeakdllkkllkkdpkkRltaeellqhpyl 216.2 3.3e-66 Protein kinase domain 374 Cluster-8541.0-2F PF07714.14 83 286 4 212 ERVVGTGSFGIVYQAKCL----ETGETVAIKKVLQDRRYK-----NRELQLMRSMDHPNVISLKHCFFstT--SrdevfLNLVMDFVPEN-MYNVLKHFsDSNQRMPLIYVKLYTYQLFRGLAYLHTVAgVCHRDIKPQNVLVDPlTHQVKICDFGSAKALVE---GEANISYICSRYYRAPELIFGATeYTTAIDIWSAGCVLAELLL-GQPLFPGENA ++ +G G+fG V+++++ ++ +va+K++ ++ + + +e+++m++++hpn+++l + + l +v+++v+++ + + L++ ++++++ l + +++q+ +G++yL+ + Hrd+ +NvL++ +++vki+DfG a+++ + +++ + ++ + apE ++ + +t++ D+Ws G +l E++ g+ +pg ++ gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvct..keep.....llivteyvegGdLlkfLrkk.eekekltlkdllsfalqiAkGmeyLeskk.lvHrdlaarNvLlse.nkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekk.ftsksDvWsfGvllwEiftlgeepypglsn 95.8 1.7e-29 Protein tyrosine kinase 374 Cluster-8600.0-0R AGC_PDK1 1 95 78 170 LESCEGGELFDQITRKGRLTEDEARFYAAEVVDALEYIHSMGLIHRDIKPENLLLTTDGHIKIADFGSVKPMQDSQITVLPnaASDDKACTFVGT lesceGGelf+qitrkgrl+e+earfyaaevvd+ley++++gl+hrd+kpenlll++dGh+k++dfGs+k+++d++++vlp as++ka++fvGt lesceGGelfeqitrkgrlseeearfyaaevvdileylrkaglvhrdlkpenlllssdGhlklidfGsakalkdlpaavlp..aseekatsfvGt 162.4 1.2e-49 AGC_PDK1 95 Cluster-8600.0-0R PF00069.22 1 76 77 152 LESCEGGELFDQITRKGRLTEDEARFYAAEVVDALEYIHSMGLIHRDIKPENLLLTTDGHIKIADFGSVKPMQDSQ le +eggel+d ++rkg l+e+ea+++a++++ +ley+Hs+g+iHrD+KpeN+L++++g++Ki+DFG +k ++ s+ leyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesss 93.8 7.5e-29 Protein kinase domain 95 Cluster-8600.0-0R PF07714.14 2 75 81 158 ESCEGGELFDQITRK---GRLTEDEARFYAAEVVDALEYIHSMGLIHRDIKPENLLLTTDGHIKIADFGSVKPM-QDS e +egG+L + +++k +lt ++ +a+++ +++ey++s+ l+Hrd+ N Ll+++ ++ki+DfG + + +d+ eyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekdd 48.6 4.2e-15 Protein tyrosine kinase 95 Cluster-861.0-2F RLK-Pelle_DLSV 1 129 53 181 NLVRLLGCCIDMEEKMLIYEYMENKSLDSILFKSEKSSLLDWKRRFTIICGIARGLLYLHLDSRFRIIHRDLKASNILLDKDMNPKISDFGMARIFGGDQTEANTKRVVGTYGYMAPEYAMDGVFSMKS nlv+Llgcci+ eek+l+yey+enksLd++lf++ek++ ldWk+rf+ii giarGllYLh +sr +iihrDlKasNiLLdk+mnpki+DFG+ar+f+ dqtea+tkrvvgt+gYmaPeya++g +s+ks nlvkLlgcciegeekllvyeylenksLdkflfdeekkkeldWktrfkiikgiarGllYLheesrlkiihrDlKasNiLLdkemnpkiaDFGlarlfeedqteastkrvvgtlgYmaPeyalegqlseks 227.3 1.5e-69 RLK-Pelle_DLSV 129 Cluster-861.0-2F PF07714.14 1 129 62 187 NLVRLLGCCIDMEEKMLIYEYMENKSLDSILFKSEKSSLLDWKRRFTIICGIARGLLYLHldsRFRIIHRDLKASNILLDKDMNPKISDFGMARIFGGDQTEANTKRVVGTYGYMAPEYAMDGVFSMKS n+v+llg+c++ e+ +++ ey+e+ +L++ L k+e+++ l+ k+ + ++ iA+G+ yL+ + +++Hrdl a N+Ll++++ kisDfG+ar d++ ++++ + +mapE ++++f+ ks nivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLe...skklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsks 95.5 2.1e-29 Protein tyrosine kinase 129 Cluster-861.0-2F PF00069.22 1 119 59 168 NLVRLLGCCIDMEEKMLIYEYMENKSLDSILFksEKSSLLDWKRRfTIICGIARGLLYLHLDSrfrIIHRDLKASNILLDKDMNPKISDFGMARIFGGDQTeanTKRVVGTYGYMAPEY n+vrl++++ + +e +l+ ey+e+++l+++l +k+sl +++ + i+ i++gl ylH + iiHrDlK +NiL+d++ + Ki+DFG+a+ + +++ ++ +vgt Y+APE nivrlyevfeekdelylvleyveggeladlls..rkgslseeeak.kiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEv 92.1 2.4e-28 Protein kinase domain 129 Cluster-8734.0-1F RLK-Pelle_DLSV 1 145 103 248 GIARGLAFLHEESRFKIVHRDIKATNVLLDGDLNPKISDFGLARLNEEEKTHIST-RVAGTIGYMAPEYALWGYLTDKADVYSFGVVVLEIVSGKSNNNYMPDSNFTCLLDLACHLQEINNIDELVDERLGSEVNMKEVAKVVKVA giarGl++Lheesr ki+hrD+Ka+N+LLd ++npki+DFGlarl ee++t++st rv+gt+gYmaPeyal g l+ k+DvysfGv+vleivsGk+n++ + +++++ ll+ a +l+e +++ elvd++l +e++++ev +++++a giarGllYLheesrlkiihrDlKasNiLLdkemnpkiaDFGlarlfeedqteastkrvvgtlgYmaPeyalegqlseksDvysfGvlvleivsGkknsslkeeeeaeelleeawklweeekllelvdkslkeeaekeevlrcieia 187.3 2.5e-57 RLK-Pelle_DLSV 147 Cluster-8734.0-1F PF00069.22 2 95 107 195 IARGLAFLHEESrfkIVHRDIKATNVLLDGDLNPKISDFGLARLNEEEKThiSTRVAGTIGYMAPEYALWGYLTDKADVYSFGVVVLEIVSGKS i++gl++lH+++ i+HrD+K N+L+d + + Ki+DFGla+ e++++ t + gt Y+APE + k+Dv+s Gv+++e+++gk ilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkp 85.8 1.9e-26 Protein kinase domain 147 Cluster-8734.0-1F PF07714.14 2 120 113 230 IARGLAFLHEESrfkIVHRDIKATNVLLDGDLNPKISDFGLARLN-EEEKTHISTRVAGTIGYMAPEYALWGYLTDKADVYSFGVVVLEIVS-GKSNNNYMPDSNFTCLLDLACHLQEINN iA+G+++L++++ +vHrd+ a NvLl+ + kisDfGLar ++++++ +++ + +mapE + +t k+Dv+sfGv++ Ei++ g++ + + +++++ l+ +l++ ++ iAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevleklkegkrlekpek 84.3 5.2e-26 Protein tyrosine kinase 147 Cluster-8744.1-2R RLK-Pelle_LRR-XI-1 1 249 24 264 AVKRIwSERKLDYNLEKEFLAEIEILGSVRHSNIVKLFCCLSSDDSKLLVYEYMENQSLDRWLYGKKKKalssvhdaVLDWPARLSIAIGAAQGLCYMHHDCSPPIIHRDVKSSNILLDADFKAKIADFGLAKIMLKKGEPNTMSAVAGSFGYIAPEYAYTTKVDEKIDVYSFGVVLLELVMGREPNSG--EEHTSLAEWAWKHytEEKPIVDVLDKEI-NEPCYLEEITTVFKLGLVCTSSMPYNRPSMKE aVK++ +++k + + ek+f ae+++lg++rh+nivkl++++ss+++kllvyeymen sL+++l gkkkk ldW+aRl+ia+g+A+gL+Y+hhdcsppi+HrDvkssniLLd++f+ak+adfglak++ +k+e++++savags+GYiaPeyayt+kv+ek+DvYSfGvvlLelv+g++p+ +e++++++w+ ++ +++ + ++lD+++ ++ + ee+++v+k++l+cts++p +RP+m+e aVKkl.eaakskekseksfeaevktlgkirhrnivkllgfcsseeakllvyeymengsLgellhgkkkk........eldWeaRlkiavgvAegLaYlhhdcsppivHrDvkssniLLdsefeakvadfglakvldekkeseslsavagsyGYiaPeyaytlkvteksDvYSfGvvlLelvtgkkpvdeefgesvdivkwvaek..kkekveeilDeklavseaaeeemlkvlkvallctsespeeRPtmre 331.4 2.6e-101 RLK-Pelle_LRR-XI-1 256 Cluster-8744.1-2R PF00069.22 1 252 28 260 AVKRIWSERKLDYNLeKEFLAEIEILGSVRHSNIVKLFCCLSSDDSKLLVYEYMENQSLDRWLYgkKKKALSSVhdavldwpARLSIAIGAAQGLCYMHHDCsppIIHRDVKSSNILLDADFKAKIADFGLAKIMLKKGEpntMSAVAGSFGYIAPEYAYTTKVDEKIDVYSFGVVLLELVMGREPNSGEEHTSLAEWAWKHYTEEKPIVDVLDKEINEPCYLeeITTVFKLGLVCTSSMPYNRPSMKESLH AvK+i e++ + + k++l+Ei+il +++h+niv+l+ +++++d+ +lv ey+e+++l+++l +k++ls+ +ia ++gl y+H+ + iiHrD+K++NiL+d + + Ki+DFGlak + ++ + ++ + g+ Y+APE ++++++k+Dv+s Gv+l+el++g++p sge++++ +e ++ ++ i++ +++++e+ l ++ +l + + p +R++++e l+ AvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls..rkgslsee........eakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeasel..seeakdllkkllkkdpkkRltaeellq 141.2 2.5e-43 Protein kinase domain 256 Cluster-8744.1-2R PF07714.14 2 251 33 257 VKRIwsERKLDYNLEKEFLAEIEILGSVRHSNIVKLFCCLSSDDSKLLVYEYMENQSLDRWLYGKkkkalssVHDAVLDWPARLSIAIGAAQGLCYMHHDCsppIIHRDVKSSNILLDADFKAKIADFGLAKIMLKKGEPNTMSAVAGSFGYIAPEYAYTTKVDEKIDVYSFGVVLLELVM-GREPnsgeehtslaewaWKHYtEEKPIVDVLDKEINEPCYLEEITTVFKLGLVCTSSMPYNRPSMKESL vK + +++ + + ++efl e++i+ +++h nivkl + +++++ l+v ey+e+ +L++ L k +++ l+ ls+a+ A+G+ y+++ ++Hrd+ + N+Ll+ + ++ki+DfGLa+ + k+ e ++ + ++ ++apE ++k+ +k Dv+sfGv+l E++ g+ep ++++ +++ +++ l+++ + ++ + +++ +l C ++ p +Rp++ke + vKtl..keeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk.......eekekltlkdllsfalqiAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep.............ypgl.sneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelv 122.8 9.7e-38 Protein tyrosine kinase 256 Cluster-8749.0-2R TKL-Pl-6 7 107 183 254 DVYSFGVILWEIATQKIPwdns*yfqevyieii*nchlnlmkvll*slslVNKIFSFQ-ILGFM--NQRLEIPRDVIPEWASIIESCWHSEPQRRPTFQELVER DvysfG++lWe+ t++ P +++ + +lg + + r+++P++ peW++++e+Cw++ep++rP+f+e++er DvysfGivlWelltgeeP................................yaslnlgaillgivkeelrpavPescdpeWreLmeaCwapepaarPsftevaer 54.8 8.2e-17 TKL-Pl-6 223 Cluster-8749.0-2R PF07714.14 5 108 186 260 VSDVYSFGVILWEIAT-QKIPwdns*yfqevyieii*nchlnlmkvll*sL-SLVNKIFSFQIlgFMNQRLEIPRDVIPEWASIIESCWHSEPQRRPTFQELVERL sDv+sfGv+lwEi+t + p + +l n+ + ++ ++rle p+++ +e+++++++Cw+++p++Rptf+elve+l ksDvWsfGvllwEiftlgeep.............................ypglsneevlekl..kegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 44.4 8.2e-14 Protein tyrosine kinase 223 Cluster-8749.1-2R TKL_CTR1-DRK-2 6 79 180 253 SDVYSFGVILWEIATQKIPWDNLNSMQVIGAVGFMNQRLEIPRDVIPEWASIIESCWHSEPQRRPTFQELVERL sdvysfGvilwe++t+kipw++ln+mqv+gavgf+n+rleip++v p++as+iescw+++p++rp+f+e++e+l sdvysfGvilwelvtekipweelnamqvvgavgfqnrrleipkevdpkvasliescwekdpkkrpsfseilekl 120.5 7.4e-37 TKL_CTR1-DRK-2 171 Cluster-8749.1-2R PF07714.14 5 79 186 260 VSDVYSFGVILWEIAT-QKIPWDNLNSMQVIGAVgFMNQRLEIPRDVIPEWASIIESCWHSEPQRRPTFQELVERL sDv+sfGv+lwEi+t + p+ +l++++v+ ++ ++rle p+++ +e+++++++Cw+++p++Rptf+elve+l ksDvWsfGvllwEiftlgeepypglsneevlekl.kegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 64.5 5.8e-20 Protein tyrosine kinase 171 Cluster-8749.1-2R PF00069.22 6 77 178 260 SDVYSFGVILWEIATQKIPWDNLNSM--------Q---VIGAVGFMNQRLEIPRDVIPEWASIIESCWHSEPQRRPTFQELVE +Dv+s Gvil+e+ t+k p+ + ++ q ++ +g +++ l+ ++++ +e ++++++++ +p++R+t++el++ vDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellq 31.6 6.7e-10 Protein kinase domain 171 Cluster-8838.0-0R RLK-Pelle_Extensin 25 294 1 268 KVIGNGAYGVVYRGVLSDGTVAAIKMLHREGRQGERAFRLEVDLLSRLRSPYIAQLLGYCADQNRRLLVFEYMPNGSLQKHLHPGKNRSKvvPLNWRIRLRIALDCARALEYLHEHTTPSIIHRNFKCSSILLDQNFRAKLSGFGLAKIGSDKLNGLISTRVLGTTGYLAPEYASTGKLTTKSDVYSYGVILLELLTGRVPIDANRPPGEHVLVSWALPRLTNRDKVEEMVDPALQGQYSNKELIQVAAIAAMCVQTEADYRPLMTDVVQ kv+G+G++G vy+Gvl+dgt +a+k+l+r+++qger f++ev+llsrl+++++ +llG+ca++++rllv+e++pnGs+++hlh ++ ++ pl+w +rl+iald+ar+l+ylhe+++p++ihr+fk+s ill+++f+ak+s fGlak +s+k ++ istrvlGt+Gy+aPeya+tG+l++ksdvysyGv+llell+Gr+P+d +rp+g+++lv+wa+P+lt+r+k+ee+vdp+l+g+ys+++l++vaaia++cvq+ea++rplm++vvq kvvGeGgfGkvykGvledgtevavkkltrddkqgereflvevellsrlhhrnlvkllGicaeeskrllvyelipnGsveshlhgsdkaka..pldwdarlkialdaarglaylhedsqprvihrdfkasnilleedftakvsdfGlakeasekakeeistrvlGtfGyvaPeyamtGhllvksdvysyGvvllellsGrkPvdmkrpegqenlvtwarPlltdrekleelvdpslegeyslddlakvaaiasvcvqpeaserplmgevvq 427.9 1.2e-130 RLK-Pelle_Extensin 357 Cluster-8838.0-0R PF00069.22 22 233 2 204 SEVKVIGNGAYGVVYRGV-LSDGTVAAIKMLHREGRQGER--AFRLEVDLLSRLRSPYIAQLLGYCADQNRRLLVFEYMPNGSLQKHLHpgknRSKVvpLNW-RIRlRIALDCARALEYLHEHTtpsIIHRNFKCSSILLDQNFRAKLSGFGLAKIGSDKLNgliSTRVLGTTGYLAPEYASTGKLTTKSDVYSYGVILLELLTGRVPIDANRPPG ++++ +G+G++G+Vy++v ++g A+K++ +e ++ ++ +++ E+ +l +l++p+i +l++++ ++++++lv+ey+++g+l+++l+ r+++ l+ +++ +ia +++leylH++ iiHr K + iL+d++ K++ FGlak + + + t + gt YlAPE ++ + ++k+Dv+s+Gvil+elltg+ p +++ ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls....rkgs..lseeeak.kiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgke 143.3 5.8e-44 Protein kinase domain 357 Cluster-8838.0-0R PF07714.14 24 296 4 260 VKVIGNGAYGVVYRGVLS-----DGTVAAIKMLHREGRQG-ERAFRLEVDLLSRLRSPYIAQLLGYCADQNRRLLVFEYMPNGSLQKHLHPGKNRSKvvpLNWRIRLRIALDCARALEYLHEHTtpsIIHRNFKCSSILLDQNFRAKLSGFGLAKIGSDKLNGLISTRVLGTTGYLAPEYASTGKLTTKSDVYSYGVILLELLT-GRVPidanrppgehvlvswaLPRLTNRDkVEEMVDPALQGQYSNKELIQVAAIAAMCVQTEADYRPLMTDVVQSL k +G+Ga+G V++g l+ + + a+K+l++e ++ +++f e++++++l+ p i +llg c ++++ l+v+ey+++G+L+k+L+ ++++k l+ + l++al+ A+++eyL++++ ++Hr+ + +Ll++n +k+s fGLa+ +++ + +++ ++apE +++k+t+ksDv+s+Gv+l E++t g+ p +p+l+n++ v e+++ + + +k +++ + C++++++ Rp ++++v+ l gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekek...ltlkdllsfalqiAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep................ypglsnee.vleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 142.5 9.2e-44 Protein tyrosine kinase 357 Cluster-8852.0-0R CAMK_OST1L 1 169 13 185 GVARLMRNKETSELVAMKYIERG-RKIDENVAREIINHRSLRHPNIIRFKELVLTPTHIAIVMEYAAGGELFDRICNAGRFSEDESRYFFQQLICGVHYCHSMQICHRDLKLENTLLDGSPAPLLKICDFGYSKSSLLHSKPKSTVGTPAYIAPEVLSK---KEYDGKLADVW Gvarl+r+ket+elvA+K+ierg +k+denv+rEi+nhrsLrHpni+rfke+vltpth+a+vmEYa+ggel+++++++gr+sede+ry+fqQl++gv+ycH++++++Rdlklen+lLdgs+apllkicDFg+skssl +skpks+vGtpayiaPevl++ keYdgk aDvw GvarlvrdketkelvAvKlierglekvdenvkrEilnhrsLrHpnivrfkevvltpthlalvmEYadggelleyvskkgrlsedearylfqQlvsgvdycHrkgvvnRdlklenllLdgseapllkicDFgfskssledskpksrvGtpayiaPevlaaakakeYdgkkaDvw 282.1 2.9e-86 CAMK_OST1L 169 Cluster-8852.0-0R PF00069.22 2 169 14 181 VARLMRNKETSELVAMKYIERGRKID---ENVAREIINHRSLRHPNIIRFKELVLTPTHIAIVMEYAAGGELFDRICNAGRFSEDESRYFFQQLICGVHYCHSMQICHRDLKLENTLLDGSPAplLKICDFGYSKSSLLHSKPKSTVGTPAYIAPEVLSKKEYdGKLADVW + +++ket++ vA+K i++ ++ + ++v+rEi +++l+hpni+r++e + +++++ +v+ey+ ggel+d++ + g +se+e + +++q++ g++y+Hs++i+HrDlK eN L+d + lKi+DFG +k +sk +s vgt+ Y+APEvl+++ey +k +DvW kVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekge..lKitDFGlakelessskltsfvgtreYlAPEvlkeney.skkvDvW 163.1 5.3e-50 Protein kinase domain 169 Cluster-8852.0-0R PF07714.14 7 169 23 190 RNKETSELVAMKYIERGRKID--ENVAREIINHRSLRHPNIIRFKELVLTPTHIAIVMEYAAGGELFDRICNA---GRFSEDESRYFFQQLICGVHYCHSMQICHRDLKLENTLLDGspAPLLKICDFGYSKSS---LLHSKPKSTVGTPAYIAPEVLSKKEYDGKlADVW ++++++ va+K ++++ + + e++ +e+ ++l+hpni+++ +++ ++ iv+ey++gG+L + + + +++ ++ f +q+ +G++y +s+++ Hrdl N Ll+ + ki+DfG +++ +k +++ ++apE+l++k++ k +DvW ekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlse..nkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsk.sDvW 82.8 1.5e-25 Protein tyrosine kinase 169 Cluster-8925.1-0F TKL-Pl-6 1 89 166 253 WMAPELLNgSSNKVSEKVDVFSFGIVLWEILTGEEPYANMYYGAIIGGIVNNTLRPTIPSHCDPEWRRLMEQCWAPNPAARPTFTEITN wmapell+ ss++vsekvDv+sfGivlWe+ltgeePya++ +gai++giv+++lrp++P++cdpeWr+Lme+Cwap+paarP+fte+++ wmapellr.sskevsekvDvysfGivlWelltgeePyaslnlgaillgivkeelrpavPescdpeWreLmeaCwapepaarPsftevae 146.7 7.1e-45 TKL-Pl-6 171 Cluster-8925.1-0F PF07714.14 1 91 172 260 WMAPELLNGSSnkVSEKVDVFSFGIVLWEILT-GEEPYANMYYGAIIGGIvNNTLRPTIPSHCDPEWRRLMEQCWAPNPAARPTFTEITNRL WmapE l+ ++ +++k Dv+sfG++lwEi+t geepy+++ ++ + ++ r + p++c +e+ +lm+qCw+ +p+ Rptf+e++++l WmapEslkekk..ftsksDvWsfGvllwEiftlgeepypglsneevlekl.kegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 82.9 1.4e-25 Protein tyrosine kinase 171 Cluster-8925.1-0F PF00069.22 1 89 163 260 WMAPELLngSSNKVSEKVDVFSFGIVLWEILTGEEPYA----NMYYGAIIGG------IV-NNTLRPTIPSHCDPEWRRLMEQCWAPNPAARPTFTEITN ++APE+l ++n++s+kvDv+s G++l+e+ltg++p++ + + +++ i+ ++++ +s++++e ++l++++++ +p R+t++e+ + YlAPEvl..keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellq 53.0 2.1e-16 Protein kinase domain 171 Cluster-8925.2-0R TKL-Pl-6 67 235 1 163 ELRELGSGTFGTVYHGKWRGSDVAIKRIKKSCFTgrqseqERLTIEFWREAEILSKLHHPNVVAFYGVVQDGPGGTLATVTEYMVDGSLRHVLLRKDRHLDRRKRLIIAMDAAFGMEYLHSKNIVHFDLKCDNLLVNLKDPSRPICKVGDFGLSKIKRNTLVSGGVRGT elrelGsGtfG+vy++kwrg+dvaikr+kks+f+ e+l+ ef++eaeilskL+hpnvva+yGvv+dgpgg+latvte++++gslr+vl +kdr+ldrrkr++ia+daa+GmeYLhsk++vhfdLk+dnLLv+l++p+rpickv+DfGLskikr+tlvsggvrGt elrelGsGtfGevylakwrgtdvaikrlkkslfa......eklvseflseaeilskLrhpnvvalyGvvkdgpggslatvteflrngslrsvlskkdrkldrrkrilialdaalGmeYLhskavvhfdLktdnLLvdlrepqrpickvaDfGLskikretlvsggvrGt 276.8 1.4e-84 TKL-Pl-6 235 Cluster-8925.2-0R PF07714.14 67 223 3 154 ELRELGSGTFGTVYHGKWR------GSDVAIKRIKKscftgrqSEQERLTIEFWREAEILSKLHHPNVVAFYGVVQdgPGGTLATVTEYMVDGSLRHVLLRK--DRHLDRRKRLIIAMDAAFGMEYLHSKNIVHFDLKCDNLLVNLkdpsRPICKVGDFGLSKIK ++lG+G+fG+V++g+++ +va+K +k+ + +e+ + ef +ea+i++kl+hpn+v+++gv+ +++l vtey+ G+L++ L +k +++l+ ++ l +a++ A GmeyL+sk++vH dl + N L++ + ++k++DfGL++ lgkklGeGafGeVvegtlkgekekkevkvavKtlke.......eateeekeefleeakimkklkhpnivkllgvct..keepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlse....nkvvkisDfGLardi 121.7 2.1e-37 Protein tyrosine kinase 235 Cluster-8925.2-0R PF00069.22 66 225 2 150 EELRELGSGTFGTVYHGK--WRGSDVAIKRIKKSCFTGRQSeqerltIEFWREAEILSKLHHPNVVAFYGVVQDgpGGTLATVTEYMVDGSLRHVLLRKDRhLDRRKRLIIAMDAAFGMEYLHSKNIVHFDLKCDNLLVNlKDPSrpiCKVGDFGLSKIKRN e+l++lG+G+fG+Vy ++ ++g vA+K+ikk+ + ++ +++rE +il kl+hpn+v +y+v+++ +l v+ey+ g+l ++l rk l+ ++ ia + g+eylHsk+i+H DlK +N+L++ ++ K++DFGl+k ++ ekleklGeGsfGkVykaveketgkivAvKkikkekakkkke......kkvlrEikilkklkhpnivrlyevfee..kdelylvleyveggeladllsrkgs.lseeeakkiakqilegleylHskgiiHrDlKpeNiLid.ekge...lKitDFGlakeles 108.2 2.9e-33 Protein kinase domain 235 Cluster-9009.0-1R TKL-Pl-4 1 236 13 253 LYKGTYCSQEVAIKILKA----ERLNTELQKEFAQEVYIMRKVRHKNVVQFIGACTKPPNLCIVTEFMSGGSVYDYLHKQKG-TFRLPSLLKVAIDVSKGMNYLHQNNIIHRDLKAANLLMDENEVVKVADFGVARVKAQTGVMTAETGTYRWMAPEVIEHKPYDHKADVFSFGVVLWELLAGKLPYEYLTPLQAAVGVVQKGLRPTVPKNTHPKFAELLERCWQQDPTRRPDFSEITELL lykg+y++q+va+Kil+a e+ ++el+kef+qev++++k++Hknvv+figactk+p+lcivte+++ggs+++yl+k+k +++l +++k+a+d+++g++ylh+++i+HrDlka+nll+de++vvK+aDfGvarv+aq++ mtaetGtyrwmaPEv+e+kpyd+k+Dv+sfg+vlWell+gk+pye ltplqaav+vvqk+lRp++pk++++++aellercw++dp++Rp+fsei++ll lykgkykeqdvavKileageekeeeaaelekefkqevavlsklkHknvvkfigactkepalcivteylkggslkkylekkkkkklklkvvvklaldiargleylhskkivHrDlkaenllldeekvvKiaDfGvarveaqseemtaetGtyrwmaPEvlekkpydrkvDvysfgivlWelltgkvpyedltplqaavavvqknlRpeipkevpealaellercwkadpekRpefseivkll 376.4 6e-115 TKL-Pl-4 288 Cluster-9009.0-1R PF07714.14 8 236 28 260 SQEVAIKILKAERLNTElQKEFAQEVYIMRKVRHKNVVQFIGACTKPPNLCIVTEFMSGGSVYDYLHKQ--KGTFRLPSLLKVAIDVSKGMNYLHQNNIIHRDLKAANLLMDENEVVKVADFGVARVK---AQTGVMTAETGTYRWMAPEVIEHKPYDHKADVFSFGVVLWELLA-GKLPYEYLtPLQAAVGVVQKGLRPTVPKNTHPKFAELLERCWQQDPTRRPDFSEITELL +++va+K+lk+e ++e ++ef +e+ im+k++h+n+v+++g+ctk +l+ivte+++gG++ ++L+k+ k +++l +ll++a++++kGm+yL++++++Hrdl a N L++en+vvk++DfG+ar ++ + + ++ ++WmapE++++k + +k+Dv+sfGv+lwE++ g+ py+ l + ++ +++g r + p++++++++el+++Cw++dp++Rp+f+e++e l evkvavKtlkeeateee.keefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypgl.sneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 242.9 2.2e-74 Protein tyrosine kinase 288 Cluster-9009.0-1R PF00069.22 8 233 24 259 SQEVAIKILKAERLNTELQKEFAQEVYIMRKVRHKNVVQFIGACTKPPNLCIVTEFMSGGSVYDYLHkQKGTFRLPSLLKVAIDVSKGMNYLHQNNIIHRDLKAANLLMDENEVVKVADFGVARVKAQTGVMTAETGTYRWMAPEVIEHKPYDHKADVFSFGVVLWELLAGKLPYEY----------LTPLQAAVGVV-QKGLRPTVPKNTHPKFAELLERCWQQDPTRRPDFSEIT +++vA+K++k e+ + + +k++++E+ i++k++h+n+v+++++++++ +l++v+e+++gg++ d+l+ +kg++ + k+a + +g++ylH+++iiHrDlK +N+L+de++++K++DFG+a+ ++ +t ++gt +++APEv+++++y++k+Dv+s Gv+l+ell+gk p++ l+ l++ + ++ ++ + ++++ +++ +ll++++++dp++R+ ++e+ gkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls.rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeell 202.5 5.2e-62 Protein kinase domain 288 Cluster-9070.0-2F NEK 69 217 1 149 YEIMEQIGRGAFGAAILVNHKLERKKYVLKKIRLARQTERCRRSAHQEMALIARIQHPYIVEFKEAWVEKGCYVCIVTGYCEGGDMAELMKKQNGQCFPEEKLLKWFTQLLLAVEYLHSNFVLHRDLKCSNIFLTKDQDVRLGDFGLAK ye+++qig+G+fg+++lv++k e+kkyvlKki+la+q+e++r++a+qE++l+++++hp+ive+ke++vek++++civ++y+egGd+ael+kk++g+ ++Eek+lk+++qllla+eylHs+ +lHrDlk+sNifltkd++++lgdfGlak yevlkqigkGsfgsvylvreksekkkyvlKkielakqsekereaalqEvkllsslkhpniveykesfvekdnklcivleyaegGdlaelikkakgkalsEekvlkllvqlllaleylHskkilHrDlktsNifltkdgkiklgdfGlak 227.6 1.5e-69 NEK 218 Cluster-9070.0-2F PF00069.22 69 217 1 146 YEIMEQIGRGAFGAAILVNHKLERKKYVLKKIRLARQTERCRRSAHQEMALIARIQHPYIVEFKEAWVEkGCYVCIVTGYCEGGDMAELMKkQNGQcFPEEKLLKWFTQLLLAVEYLHSNFVLHRDLKCSNIFLTKDQDVRLGDFGLAK ye +e++G+G+fG + + +k ++k++++Kki+ +++++ ++++ +E++++++++hp+iv+++e++ e ++++v+ y+egg++a+l++ ++g+ ++ee++ k+++q+l ++eylHs+ ++HrDlK +Ni+++++++++++DFGlak yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee.kdelylvleyveggeladlls.rkgs.lseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlak 132.3 1.3e-40 Protein kinase domain 218 Cluster-9070.0-2F PF07714.14 70 217 2 152 EIMEQIGRGAFGAAILVNHK---LERKKYVLKKIRLARQTERCRRSAHQEMALIARIQHPYIVEFKEAWVeKGCYVCIVTGYCEGGDMAELMKKQ-NGQCFPEEKLLKWFTQLLLAVEYLHSNFVLHRDLKCSNIFLTKDQDVRLGDFGLAK e+ +++G+GafG + + k +++ v K+ +++te+ +++ +e++++ +++hp iv++ + + k+ ++ivt y+egGd+ + ++k+ + + + ++ll++ +q+ ++eyL+s+ ++Hrdl + N++l++++ v+++DfGLa+ elgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvct.keepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLar 93.3 9.5e-29 Protein tyrosine kinase 218 Cluster-9082.0-2R CMGC_CDK-Pl 45 328 1 290 YQKLKKLGKGSYGDVYKGRHILTGADVALKEVKWPDKSQGVPKTTIREVSLLKQLVHD-NIVRLLDVVY----VDDKICLAFEYLDMDLKEYMLTCQP--LSKNPYMVKGFLYQILCGIVHCHSQDIIHRDLKTRNLLIDKRTNTIKIAGFALARELDVPGQSITPERMTLWYGAPEILLGSHGYSSAVDIWSVGCIFGEMISSKVPFRGSSKIDQLNRIFSVLGSPTEDTWPGVMSLPFFPQVSQnLPPKELITIAPALDQVGLDLLAKMLCLDPAKRIDAKSALEHEYF y+kl+k+G+G yG vyk r+ tg+ valk+++ ++++Gvp t++re+sllk+l ++ nivrll+v+ + ++ l feyld+dlk ++ +++ ++++ +vk +lyq+l+G+ +chs+ ++hrdlk +nll+dk+++++kia + lar + vp +s t+e +tlwy ape+llG++ ys++vd+wsvgcif e+++ k f G+s++dql +if +lG+p+e++wpGv++l+ + ++ + +pk+l +i+p l++ gldll+kml ++pakri ak+aleh+yf yeklekvGeGtyGkvykardkatgklvalkkirleeeeeGvpstalreisllkelsksinivrlleveklekeskkalylvfeyldldlkkfldllrkgskaleaklvksllyqllkGvaychshgvlhrdlkpqnllvdkkkealkiadlGlaraftvpvksythevvtlwyrapevllGakhystpvdlwsvgcifaelvrkkplfpGdseldqllkifrllGtpneevwpGvsklrdwkeypk.wkpkdleeivpeleeagldllskmlkyepakrisakaalehpyf 348.6 2.1e-106 CMGC_CDK-Pl 378 Cluster-9082.0-2R PF00069.22 45 328 1 264 YQKLKKLGKGSYGDVYKGRHILTGADVALKEVKWPDKSQGVPKTTIREVSLLKQLVHDNIVRLLDVVYVDDKICLAFEYLDMD-LKEYMLtcQPLSKNPYMVKGFLYQILCGIVHCHSQDIIHRDLKTRNLLIDkRTNTIKIAGFALARELDVPGQsITPERMTLWYGAPEILlGSHGYSSAVDIWSVGCIFGEMISSKVPFR---GSS----KIDQLNRIFSVLGsPTEDTWPGVMSLpffpqvsqnlppkelitiapalDQVGLDLLAKMLCLDPAKRIDAKSALEHEYF y+kl+klG+Gs+G Vyk+++ tg vA+K++k ++++ k+++rE+++lk+l h+nivrl++v++ +d+++l +ey++ + l++++ + s ++ +k +++qil g+ ++Hs+ iiHrDlK+ N+Lid +++ +Ki+ F la+el+ + t + +t +Y APE+l ++++ys++vD+Ws+G+i+ e+++ k pf+ g++ ++dql +i+ +lg +t+ ++p +l ++ +dll k+l+ dp kR+ a+++l+h+y+ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls..rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLid.ekgelKitDFGlakelesssk.ltsfvgtreYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.etkeklpeasel......................seeakdllkkllkkdpkkRltaeellqhpyl 220.3 1.9e-67 Protein kinase domain 378 Cluster-9082.0-2R PF07714.14 47 257 3 219 KLKKLGKGSYGDVYKGRHI----LTGADVALKEVKWPDKSQGvPKTTIREVSLLKQLVHDNIVRLLDVVYVDDKICLAFEYLDM-DLKEYMLTC-QPLSKNPYMVKGFLYQILCGIVHCHSQDIIHRDLKTRNLLIDKrTNTIKIAGFALAREL--DVPGQSITPERMTLWYGAPEILLGSHgYSSAVDIWSVGCIFGEMIS-SKVPFRGSSKIDQLNRI kklG+G++G+V++g+ + +va+K +k +++ + ++e++++k+l h+niv+ll v++ ++++++ +ey++ dL++++ + + + + + f +qi +G+ + +s++++Hrdl +rN L+++ ++++ki+ f+Lar++ d ++ + +++ + + apE+l ++ ++s+ D+Ws G + E+++ ++ p++g s+ + l+++ lgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateee.keefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlse.nkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekk.ftsksDvWsfGvllwEiftlgeepypglsneevlekl 112.8 1.1e-34 Protein tyrosine kinase 378 Cluster-9095.0-0F CMGC_CDK-Pl 29 312 1 290 YEKVEKIGEGTYGVVYKARDRVTNETIALKKIRLEHEDEGVPSTAIREISLLKEMQHG-NIVRLQDVVH----SEKRLYLVFEYLDLDLKKHMDSCPE--FSKDPRLVKMFLYQILRGIAYCHSHRVLHRDLKPQNLLIDRHTNALKLADFGLARAFGIPVRTFTHEVVTLWYRAPEILLGSRHYSTPVDVWSVGCIFAEMVNRQPLFPGDSEIDELFKIFRIMGTPNEDTWPGVSSLPDFKsSFPKWPLKDLATVVPNLDAAGLDLLLKMLCLDPSRRITAKSALGHEYF yek+ek+GeGtyG+vykard++t++++alkkirle+e+eGvpsta+reisllke+++ nivrl++v++ s+k+lylvfeyldldlkk++d++++ +++++lvk++lyq+l+G+aychsh+vlhrdlkpqnll+d++++alk+ad+Glaraf++pv+++thevvtlwyrape+llG++hystpvd+wsvgcifae+v+++plfpGdse+d+l+kifr++Gtpne++wpGvs+l+d+k ++pkw+ kdl+++vp+l++agldll kml ++p++ri+ak+al h+yf yeklekvGeGtyGkvykardkatgklvalkkirleeeeeGvpstalreisllkelsksinivrlleveklekeskkalylvfeyldldlkkfldllrkgskaleaklvksllyqllkGvaychshgvlhrdlkpqnllvdkkkealkiadlGlaraftvpvksythevvtlwyrapevllGakhystpvdlwsvgcifaelvrkkplfpGdseldqllkifrllGtpneevwpGvsklrdwk.eypkwkpkdleeivpeleeagldllskmlkyepakrisakaalehpyf 498.6 4.2e-152 CMGC_CDK-Pl 397 Cluster-9095.0-0F PF00069.22 29 312 1 264 YEKVEKIGEGTYGVVYKARDRVTNETIALKKIRLEHEDEGVPSTAIREISLLKEMQHGNIVRLQDVVHSEKRLYLVFEYLDLD-LKKHMDscPEFSKDPRLVKMFLYQILRGIAYCHSHRVLHRDLKPQNLLIDrHTNALKLADFGLARAFGIPVRtFTHEVVTLWYRAPEILlGSRHYSTPVDVWSVGCIFAEMVNRQPLFP---GDS----EIDELFKIFRIMGtPNEDTWPGVSSLpdfkssfpkwplkdlatvvpnlDAAGLDLLLKMLCLDPSRRITAKSALGHEYF yek+ek+GeG++G+Vyka+++ t++++A+Kki+ e++++ ++++rEi++lk+++h nivrl +v++++++lylv+ey++ + l++++ + s +++ +k +++qil+g++y+Hs++++HrDlKp+N+Lid +++ lK++DFGla+ + + +t++v+t +Y+APE+l ++++ys++vDvWs+G+i++e+++++p+f+ g++ e+d+l+ki++i+g +++ ++p s+l + +dll k+l+ dp++R+ta+++l h+y+ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls..rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLid.ekgelKitDFGlakelesssk.ltsfvgtreYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.etkeklpeasel......................seeakdllkkllkkdpkkRltaeellqhpyl 264.9 4.7e-81 Protein kinase domain 397 Cluster-9095.0-0F PF07714.14 32 224 4 201 VEKIGEGTYGVVYKARDR----VTNETIALKKIRLEHEDEGvPSTAIREISLLKEMQHGNIVRLQDVVHSEKRLYLVFEYLDL-DLKKHMDSC--PEFSKDPRLVKmFLYQILRGIAYCHSHRVLHRDLKPQNLLIDRhTNALKLADFGLARAF--GIPVRTFTHEVVTLWYRAPEILLGSRhYSTPVDVWSVGCIFAEMVN +k+GeG++G V++++ + ++ ++a+K+++ e+++e + ++e++++k+++h niv+l v+ +e++l++v+ey++ dL+k++ + e + +l++ f +qi +G++y +s++++Hrdl +N L+++ ++ k++DfGLar+ ++ +++ + + + apE+l ++ +++ DvWs G + E+++ gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateee.keefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdlls.falqiAkGmeyLeskklvHrdlaarNvLlse.nkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekk.ftsksDvWsfGvllwEift 109.9 8.4e-34 Protein tyrosine kinase 397 Cluster-9095.1-0F CMGC_CDK-Pl 45 328 1 290 YEKVEKIGEGTYGVVYKARDRETNETIALKKIRLEHEDEGVPSTAIREISLLKEMQHG-NIVRLQDVVH----SEKRLYLVFEYLDLDLKKHMDSCPE--FSKDPRLVKMFLYQILRGIAYCHSHRVLHRDLKPQNLLIDRHTNALKLADFGLARAFGIPVRTFTHEVVTLWYRAPEILLGSRHYSTPVDVWSVGCIFAEMVNRQPLFPGDSEIDELFKIFRIMGTPNEDTWPGVSSLPDFKsSFPKWPLKDLATVVPNLDAAGLDLLLKMLCLDPSRRITAKSALGHEYF yek+ek+GeGtyG+vykard++t++++alkkirle+e+eGvpsta+reisllke+++ nivrl++v++ s+k+lylvfeyldldlkk++d++++ +++++lvk++lyq+l+G+aychsh+vlhrdlkpqnll+d++++alk+ad+Glaraf++pv+++thevvtlwyrape+llG++hystpvd+wsvgcifae+v+++plfpGdse+d+l+kifr++Gtpne++wpGvs+l+d+k ++pkw+ kdl+++vp+l++agldll kml ++p++ri+ak+al h+yf yeklekvGeGtyGkvykardkatgklvalkkirleeeeeGvpstalreisllkelsksinivrlleveklekeskkalylvfeyldldlkkfldllrkgskaleaklvksllyqllkGvaychshgvlhrdlkpqnllvdkkkealkiadlGlaraftvpvksythevvtlwyrapevllGakhystpvdlwsvgcifaelvrkkplfpGdseldqllkifrllGtpneevwpGvsklrdwk.eypkwkpkdleeivpeleeagldllskmlkyepakrisakaalehpyf 498.4 4.7e-152 CMGC_CDK-Pl 413 Cluster-9095.1-0F PF00069.22 45 328 1 264 YEKVEKIGEGTYGVVYKARDRETNETIALKKIRLEHEDEGVPSTAIREISLLKEMQHGNIVRLQDVVHSEKRLYLVFEYLDLD-LKKHMDscPEFSKDPRLVKMFLYQILRGIAYCHSHRVLHRDLKPQNLLIDrHTNALKLADFGLARAFGIPVRtFTHEVVTLWYRAPEILlGSRHYSTPVDVWSVGCIFAEMVNRQPLFP---GDS----EIDELFKIFRIMGtPNEDTWPGVSSLpdfkssfpkwplkdlatvvpnlDAAGLDLLLKMLCLDPSRRITAKSALGHEYF yek+ek+GeG++G+Vyka+++et++++A+Kki+ e++++ ++++rEi++lk+++h nivrl +v++++++lylv+ey++ + l++++ + s +++ +k +++qil+g++y+Hs++++HrDlKp+N+Lid +++ lK++DFGla+ + + +t++v+t +Y+APE+l ++++ys++vDvWs+G+i++e+++++p+f+ g++ e+d+l+ki++i+g +++ ++p s+l + +dll k+l+ dp++R+ta+++l h+y+ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls..rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLid.ekgelKitDFGlakelesssk.ltsfvgtreYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.etkeklpeasel......................seeakdllkkllkkdpkkRltaeellqhpyl 266.8 1.2e-81 Protein kinase domain 413 Cluster-9095.1-0F PF07714.14 48 240 4 201 VEKIGEGTYGVVYKARDR----ETNETIALKKIRLEHEDEGvPSTAIREISLLKEMQHGNIVRLQDVVHSEKRLYLVFEYLDL-DLKKHMDSC--PEFSKDPRLVKmFLYQILRGIAYCHSHRVLHRDLKPQNLLIDRhTNALKLADFGLARAF--GIPVRTFTHEVVTLWYRAPEILLGSRhYSTPVDVWSVGCIFAEMVN +k+GeG++G V++++ + +++ ++a+K+++ e+++e + ++e++++k+++h niv+l v+ +e++l++v+ey++ dL+k++ + e + +l++ f +qi +G++y +s++++Hrdl +N L+++ ++ k++DfGLar+ ++ +++ + + + apE+l ++ +++ DvWs G + E+++ gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateee.keefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdlls.falqiAkGmeyLeskklvHrdlaarNvLlse.nkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekk.ftsksDvWsfGvllwEift 111.4 3e-34 Protein tyrosine kinase 413 Cluster-9116.0-1R RLK-Pelle_LRR-II 96 250 1 155 RNILGRGGFGKVYKGRLADGSLVAVKRLKEERTQGGELQFQTEVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRERLESQPPLDWAIRKRIALGAARGLAYLHDHCDPKIIHRDVKAANILLDEDFEAVVGDFGLAKLMDYKDT +nilG+GgfgkvykGrladg+lvavkrlkee+++ggelqfqteve+is+avhrnllrl+Gfc+t+terllvypym+ngsvas+lre+ e++p+ldw rkrialGaarGl+ylh++cdpkiihrdvkaanillde+feavvgdfglakl+d+kd+ knilGkGgfgkvykGrladgtlvavkrlkeeesaggelqfqtevelislavhrnllrliGfcttsterllvypymengsvasrlrelkegkpaldwetrkrialGaarGlsylheqcdpkiihrdvkaanilldeefeavvgdfglaklldkkds 300.8 6e-92 RLK-Pelle_LRR-II 250 Cluster-9116.0-1R PF00069.22 95 247 3 150 NRNILGRGGFGKVYKGR-LADGSLVAVKRLKEERTQGGEL-QFQTEVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRerleSQPPLDWAIRKRIALGAARGLAYLHDHCdpkIIHRDVKAANILLDEDFEAVVGDFGLAKLMDY + + lG+G+fGkVyk++ ++g vAvK++k+e+++ + ++++E++++ h+n++rl +++ +++e++lv y+ +g++a+ l+ + l+ + k+ia ++gl+ylH+++ iiHrD+K +NiL+de+ e ++DFGlak ++ kleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls....rkgslseeeakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakeles 109.7 1.1e-33 Protein kinase domain 250 Cluster-9116.0-1R PF07714.14 96 246 4 155 RNILGRGGFGKVYKGRLA-----DGSLVAVKRLKEERTQGGELQFQTEVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRERlESQPPLDWAIRKRIALGAARGLAYLHDHcdpKIIHRDVKAANILLDEDFEAVVGDFGLAKLMD + lG+G fG+V++g+l + vavK lkee t+ + +f +e+++++ h+n+++l g+c+ + l+v y+++G++ + Lr++ e++++l+ ++al A+G++yL+++ k++Hrd+ a N+Ll+e+ + ++DfGLa+ + gkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkk.eekekltlkdllsfalqiAkGmeyLesk...klvHrdlaarNvLlsenkvvkisDfGLardie 104.0 5.2e-32 Protein tyrosine kinase 250 Cluster-9167.0-2R CAMK_CDPK 1 154 106 259 MRQILSVVAYCHLQGVVHRDLKPENFLYCSKEDNSPLKAIDFGLSDYVKPDERLNDIVGSAYYVAPEVLHRSYGTEADMWSIGVIAYILLCGSRPFWARTESGIFRAVQKADPGFDEDPWPSLSAEAIDFVKKLLNKDYRKRMTAAQALCHPWL +rqil+vva+cH +gvvhrDlKPeNfl+ ske+++plkaiDFGls++vk++erl+divGs+yyvaPEvl+rsyg+ead+Ws+Gvi+yillcg++pfwa+te++if+av ka++ f+++pw+s+s+ea d+v++lL+kd +kR+ta+q+L hpWl vrqilevvaacHskgvvhrDlKPeNflltskeedaplkaiDFGlsvfvkegerledivGspyyvaPEvlkrsygkeadvWsaGvilyillcgvppfwaeteeeifkavlkaeldfksepwksvseeakdlvrrlLekdpkkRltaeqvLehpWl 249.2 4e-76 CAMK_CDPK 289 Cluster-9167.0-2R PF00069.22 1 154 104 264 MRQILSVVAYCHLQGVVHRDLKPENFLYCSKEDnspLKAIDFGLSDYVKPDERLNDIVGSAYYVAPEVL-HRSYGTEADMWSIGVIAYILLCGSRPFWARTESGIFRAVQKA---------DPGFDEDPWPSLSAEAIDFVKKLLNKDYRKRMTAAQALCHPWL ++qil+ ++y+H +g++HrDlKpeN+L+ +k++ lK +DFGl+ ++ +++l+++vg+ +Y+APEvl +++y++++D+Ws+Gvi y ll+g pf++++++ +++ + + ++ + + +ls ea+d++kkll+kd +kR+ta+++l hp+l akqilegleylHskgiiHrDlKpeNiLidekge...lKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 150.1 4.7e-46 Protein kinase domain 289 Cluster-9167.0-2R PF07714.14 2 145 111 253 RQILSVVAYCHLQGVVHRDLKPENFLYCSkedNSPLKAIDFGLSDYVKPDERL---NDIVGSAYYVAPEVLH-RSYGTEADMWSIGVIAYILLC-GSRPFWARTESGIFRAVQKADPgfdEDPWPSLSAEAIDFVKKLLNKDYRKRMTA +qi + ++y + + +vHrdl N L ++ n+ k DfGL++ ++ d++ ++ + ++apE+l+ +++ +++D+Ws Gv+ + +++ g++p++ +++ +++++++ + + ++e +++k+ +++d ++R t lqiAkGmeyLeskklvHrdlaarNvLlse...nkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevleklkegkr...lekpekcpeelyelmkqCweedpeeRptf 44.5 7.5e-14 Protein tyrosine kinase 289 Cluster-9168.0-1R RLK-Pelle_LRR-III 1 173 92 264 HLDWEMRIKIAIGAARGIARIHAENGGKFVHGNIKSANIFLNPHQYGCVSDLGLSTITSALARPIARAAGYRAPEVTDTRKATQPSDVYSFGVMLLELLTGKSPVHTTNGDEIINLVRWVHSVVREEWTAEVFDVELLRYPNIEEELVEMLQIAMSCVVRMPDQRPKISEVVK +ldwe+r+kia+g+arG+a +h+e+ +k+vHgn+ks ni+l+++ +++sd+gL++++++ a+ ara+gyraPE++++rka+q sDVYsfGv+lLElltgksp+++++ +e ++l++wv+svv+ee+taevfdvel+++ ++eeelve+lq+a++Cv + p++Rpk++evvk pldwearlkialgvarGlaylheesekklvHgnlkssniLldadlearisdygLarllasaaaasaralgyraPElakarkasqksDVYsfGvvlLElltgkspskasseeeevdlpkwvrsvveeektaevfdvelvkekeaeeelvellqvalaCvaaspekRpkmkevvk 222.7 3.9e-68 RLK-Pelle_LRR-III 278 Cluster-9168.0-1R PF00069.22 9 173 102 260 KIAIGAARGIARIHAENggkFVHGNIKSANIFLNPHQYGCVSDLGLSTITSALA--RPIARAAGYRAPEVTDTRKATQPSDVYSFGVMLLELLTGKSPVHTTNGDEIINLV-RW---VHSVVReewtaevfdVELLRYPNIEEELVEMLQIAMSCVVRMPDQRPKISEVVK kia ++g++ +H+++ ++H +K++Ni+++ ++ ++D+Gl++ + + + Y+APEv ++++ ++++Dv+s Gv+l+elltgk p + ++g+e ++ + + +++ + + +p+ +e e++++ +++ + p +R+ ++e+++ kiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.........etkeklpeaselseeakdllkkllkkdpkkRltaeellq 70.0 1.3e-21 Protein kinase domain 278 Cluster-9168.0-1R PF07714.14 2 174 101 259 LDWEMRIKIAIGAARGIARIHAENggkFVHGNIKSANIFLNPHQYGCVSDLGLSTIT-----SALARPIARAAGYRAPEVTDTRKATQPSDVYSFGVMLLELLT-GKSPvhttngdeiinlvrwVHSVVREEWTAEVFDVEllRYPNIEEELVEMLQIAMSCVVRMPDQRPKISEVVKM l+ + +++a+ A+G++ +++++ +vH ++ + N++l+ ++ +sD GL+ + + + apE+ +++k t+ sDv+sfGv+l E++t g++p ++++ ee ++ + + + r ++ e+ e+ ++ ++C+ + p++Rp+++e+v+ ltlkdllsfalqiAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep...............ypglsneevleklkegk..rlekpekcpeelyelmkqCweedpeeRptfkelvek 62.4 2.7e-19 Protein tyrosine kinase 278 Cluster-92.0-0R RLK-Pelle_SD-2b 61 214 2 155 QELGRGAFGTVYKGVTPSnpRRYIAVKMLKKVePEGEKEFKTEVNAIGMTHHKNLVALLGYCDEGENRLLVYEYMKNGSLATLLF---GVSRPHWNQRVQIVCGIARGFTYLHEECSTQIIHCDVKPQNILLDEFLTPKISDFGLAKLLLAEQSRAA ++lG+G+fg+Vykgv + ++ +avK l+kv +gekef++ev++ig+++h nLv llG+c ege+rllvyey++ngsL++llf + +w++r++i+ g+Arg +yLHeec+++iihcd+kp+niLlde ++pki+dfGlakll +qsr++ eklGeGgfgsVykgvled..etkvavKklekv.eqgekefraevsvigsiqhvnLvrllGfcsegekrllvyeyvengsLdkllfkkkskkvlewktrlkialgvArglayLHeecrekiihcdikpeniLldekfepkiadfGlakllkrdqsrvl 216.9 2.5e-66 RLK-Pelle_SD-2b 217 Cluster-92.0-0R PF00069.22 60 210 4 152 KQELGRGAFGTVYKGVTPSNpRRYIAVKMLKKVEPEGEKE--FKTEVNAIGMTHHKNLVALLGYCDEGENRLLVYEYMKNGSLATLLFGVSRPHWNQRVQIVCGIARGFTYLHEECstqIIHCDVKPQNILLDEFLTPKISDFGLAKLLLAEQ +++lG+G+fG+Vyk+v ++ ++ +AvK++kk + + +ke + +E++ + ++h+n+v l++++ e ++++lv ey+++g+la+ll + ++ +i+ i++g+ ylH+++ iiH+D+Kp+NiL+de Ki+DFGlak l ++ leklGeGsfGkVykaveket.gkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesss 116.0 1.2e-35 Protein kinase domain 217 Cluster-92.0-0R PF07714.14 59 210 3 158 FKQELGRGAFGTVYKGVTP---SNPRRYIAVKMLKKVEPEG-EKEFKTEVNAIGMTHHKNLVALLGYCDEGENRLLVYEYMKNGSLATLLFGV---SRPHWNQRVQIVCGIARGFTYLHEEcstQIIHCDVKPQNILLDEFLTPKISDFGLAKLLLAEQ ++++lG+GafG+V++g ++ + +avK+lk+ e ++ef +e++ + ++h+n+v+llg c ++e+ l+v ey+++G+L + L ++ + ++ ++++ iA+G yL+++ +++H d+ +N+Ll+e + kisDfGLa+ + ++ lgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLesk...klvHrdlaarNvLlsenkvvkisDfGLardiekdd 110.7 4.7e-34 Protein tyrosine kinase 217 Cluster-9266.0-0F CMGC_MAPK 12 125 175 288 ICCLQYTPAIDIWSIGCIFVEVLTGKPLFPGKSVVHQLDLITDLLGTPSADTIAGVRNEKARKYLAGMRKKQPMRFAEKFPKADPASLNLLKRMLAFDPKDRPTAEEALADPYF +++ +Yt+aiD+Ws+GCif+e+lt+kplfpgk+vv+ql+lit+l+Gtps++++ vr+ekar+yl ++kk+++++++kfpk+d+++l+Ll+r+lafdPk+r+taeeala+py+ lssskYtsaiDvWsvGCifaelltrkplfpgkdvvdqlkliteliGtpseedlesvrsekarrylkklpkkakkslkkkfpkvdelaldLlerllafdPkkritaeealahpyl 155.5 1.3e-47 CMGC_MAPK 509 Cluster-9266.0-0F PF00069.22 16 125 173 264 QYTPAIDIWSIGCIFVEVLTGKPLFP---GKS----VVHQLDLITDLLGtpsaD---------TIagvrnekarkylagmrkkqpmrfaekfpkaDPASLNLLKRMLAFDPKDRPTAEEALADPYF +y++++D+Ws+G+i++e+ltgkp+f+ gk+ ++ql i+++lg + ++ ++ ++llk++l+ dpk+R+taee+l++py+ eyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg....etkeklpeasel..............................seeakdllkkllkkdpkkRltaeellqhpyl 53.6 1.3e-16 Protein kinase domain 509 Cluster-9266.1-0F CMGC_MAPK 315 429 174 288 IFLFFKYTPAIDIWSIGCIFVEVLTGKPLFPGKSVVHQLDLITDLLGTPSADTIAGVRNEKARKYLAGMRKKQPMRFAEKFPKADPASLNLLKRMLAFDPKDRPTAEEALADPYF + + kYt+aiD+Ws+GCif+e+lt+kplfpgk+vv+ql+lit+l+Gtps++++ vr+ekar+yl ++kk+++++++kfpk+d+++l+Ll+r+lafdPk+r+taeeala+py+ llssskYtsaiDvWsvGCifaelltrkplfpgkdvvdqlkliteliGtpseedlesvrsekarrylkklpkkakkslkkkfpkvdelaldLlerllafdPkkritaeealahpyl 152.9 8.5e-47 CMGC_MAPK 813 Cluster-9266.1-0F PF00069.22 320 429 173 264 KYTPAIDIWSIGCIFVEVLTGKPLFP---GKS----VVHQLDLITDLLGtpsaD---------TIagvrnekarkylagmrkkqpmrfaekfpkaDPASLNLLKRMLAFDPKDRPTAEEALADPYF +y++++D+Ws+G+i++e+ltgkp+f+ gk+ ++ql i+++lg + ++ ++ ++llk++l+ dpk+R+taee+l++py+ eyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg....etkeklpeasel..............................seeakdllkkllkkdpkkRltaeellqhpyl 51.7 5e-16 Protein kinase domain 813 Cluster-9266.1-1F CMGC_MAPK 122 302 1 178 YKIVEIIGKGSYGVVCSAIDTQTGEKVAIKKIKDIFEHNSDAIRILREIKLLRLLRHPDIVEIKRIMLPSSRRDFRDIYVVFELMESDLHQVIKANDDLTHEHHRFFLYQMLRALKYMHTANVYHRDLKPKNILANANCKLKICDLGLARVAfndAPTAIFWTDYVATRWYRAPELCGSFS yk++e iGkGsygvvcsa+dt+tgekvaikki+d+fe+++da r+lreikllr l+h++ive+k ++ p+++++f+D+y+v+elm++dlhqvik+nd+lt+eh++++lyq+lr+lky+h+anv+hrDlkpkn+l+nancklkicD+Glar+a ++++ ++t+yv+trwyraPel+ s+s ykleeviGkGsygvvcsavdtetgekvaikkiedvfenlidakrvlreikllrrlehenivelkdvlkpaekeefkDvyivlelmdtdlhqviksndelteehvqyllyqllrglkylhsanvlhrDlkpknlllnancklkicDfGlarsa...ssetdllteyvvtrwyraPelllsss 300.7 7.5e-92 CMGC_MAPK 813 Cluster-9266.1-1F PF00069.22 122 298 1 169 YKIVEIIGKGSYGVVCSAIDTQTGEKVAIKKIKDIFEHNSDAIRILREIKLLRLLRHPDIVEIKRIMLPssrrdFRDIYVVFELMESD-LHQVIKANDDLTHEHHRFFLYQMLRALKYMHTANVYHRDLKPKNILANANCKLKICDLGLARVAFNDAPtaifWTDYVATRWYRAPELC y+ +e +G+Gs+G+V +a++++tg++vA+Kkik + +++ ++lrEik+l+ l+hp iv++++++ +++y+v+e++e + l+++++++ l++e+ +++++q+l++l+y+H +++ HrDlKp+NiL + + +lKi+D+Gla+ + ++ + t++v+tr+Y+APE+ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee.....kdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk....ltsfvgtreYlAPEvl 156.7 4.8e-48 Protein kinase domain 813 Cluster-9266.1-1F PF07714.14 124 297 3 177 IVEIIGKGSYGVVCSAIDT----QTGEKVAIKKIKDIFEHNSdAIRILREIKLLRLLRHPDIVEIKRIMLpsS--RrdfrdIYVVFELMES-DLHQVIKAN---DDLTHEHHRFFLYQMLRALKYMHTANVYHRDLKPKNILANANCKLKICDLGLARVAFNDAPTAIFWTDYVATRWYrAPEL + + +G+G++G V++++ + ++ kva+K++k+ ++++ ++l+e+k+++ l+hp iv++ +++ + + +++v+e++e+ dL++ ++++ + lt ++ f +q+ ++++y++ ++ Hrdl +N+L + n + ki+D GLar +d + ++ + +W+ apE lgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateee.keefleeakimkklkhpnivkllgvct..keep.....llivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWm.apEs 88.9 2.2e-27 Protein tyrosine kinase 813 Cluster-9266.2-1F CMGC_MAPK 122 413 1 288 YKIVEIIGKGSYGVVCSAIDTQTGEKVAIKKIKDIFEHNSDAIRILREIKLLRLLRHPDIVEIKRIMLPSSRRDFRDIYVVFELMESDLHQVIKANDDLTHEHHRFFLYQMLRALKYMHTANVYHRDLKPKNILANANCKLKICDLGLARVAfndAPTAIFWTDYVATRWYRAPELCGSfSSKYTPAIDIWSIGCIFVEVLTGKPLFPGKSVVHQLDLITDLLGTPSADTIAGVRNEKARKYLAGMRKKQPMRFAEKFPKADPASLNLLKRMLAFDPKDRPTAEEALADPYF yk++e iGkGsygvvcsa+dt+tgekvaikki+d+fe+++da r+lreikllr l+h++ive+k ++ p+++++f+D+y+v+elm++dlhqvik+nd+lt+eh++++lyq+lr+lky+h+anv+hrDlkpkn+l+nancklkicD+Glar+a ++++ ++t+yv+trwyraPel+ s sskYt+aiD+Ws+GCif+e+lt+kplfpgk+vv+ql+lit+l+Gtps++++ vr+ekar+yl ++kk+++++++kfpk+d+++l+Ll+r+lafdPk+r+taeeala+py+ ykleeviGkGsygvvcsavdtetgekvaikkiedvfenlidakrvlreikllrrlehenivelkdvlkpaekeefkDvyivlelmdtdlhqviksndelteehvqyllyqllrglkylhsanvlhrDlkpknlllnancklkicDfGlarsa...ssetdllteyvvtrwyraPellls.sskYtsaiDvWsvGCifaelltrkplfpgkdvvdqlkliteliGtpseedlesvrsekarrylkklpkkakkslkkkfpkvdelaldLlerllafdPkkritaeealahpyl 471.9 5.1e-144 CMGC_MAPK 797 Cluster-9266.2-1F PF00069.22 122 413 1 264 YKIVEIIGKGSYGVVCSAIDTQTGEKVAIKKIKDIFEHNSDAIRILREIKLLRLLRHPDIVEIKRIMLPssrrdFRDIYVVFELMESD-LHQVIKANDDLTHEHHRFFLYQMLRALKYMHTANVYHRDLKPKNILANANCKLKICDLGLARVAFNDAPtaifWTDYVATRWYRAPELCgsFSSKYTPAIDIWSIGCIFVEVLTGKPLFP---GKS----VVHQLDLITDLLGtpsaD---------TIagvrnekarkylagmrkkqpmrfaekfpkaDPASLNLLKRMLAFDPKDRPTAEEALADPYF y+ +e +G+Gs+G+V +a++++tg++vA+Kkik + +++ ++lrEik+l+ l+hp iv++++++ +++y+v+e++e + l+++++++ l++e+ +++++q+l++l+y+H +++ HrDlKp+NiL + + +lKi+D+Gla+ + ++ + t++v+tr+Y+APE+ +++y++++D+Ws+G+i++e+ltgkp+f+ gk+ ++ql i+++lg + ++ ++ ++llk++l+ dpk+R+taee+l++py+ yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee.....kdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk....ltsfvgtreYlAPEvl..keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg....etkeklpeasel..............................seeakdllkkllkkdpkkRltaeellqhpyl 225.6 4.4e-69 Protein kinase domain 797 Cluster-9266.2-1F PF07714.14 124 405 3 254 IVEIIGKGSYGVVCSAIDT----QTGEKVAIKKIKDIFEHNSdAIRILREIKLLRLLRHPDIVEIKRIMLpsS--RrdfrdIYVVFELMES-DLHQVIKAN---DDLTHEHHRFFLYQMLRALKYMHTANVYHRDLKPKNILANANCKLKICDLGLARVAFNDAPTAIFWTDYVATRWYrAPELCgsFSSKYTPAIDIWSIGCIFVEVLT-GK-PlfpgksvvhqldlitdllgtpsadtIAGVRNEKARKYLagmRKKQPMRFAEkfpKADPASLNLLKRMLAFDPKDRPTAE + + +G+G++G V++++ + ++ kva+K++k+ ++++ ++l+e+k+++ l+hp iv++ +++ + + +++v+e++e+ dL++ ++++ + lt ++ f +q+ ++++y++ ++ Hrdl +N+L + n + ki+D GLar +d + ++ + +W+ apE +++k+t + D+Ws G + E++t g+ p ++g++ne++ ++l ++++ ++ e k+ ++ +l+k+ ++ dp++Rpt + lgkklGeGafGeVvegtlkgekekkevkvavKtlkeeateee.keefleeakimkklkhpnivkllgvct..keep.....llivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWm.apEsl..kekkftsksDvWsfGvllwEiftlgeep.........................ypglsneevlekl...kegkrlekpe...kcpeelyelmkqCweedpeeRptfk 110.1 7.4e-34 Protein tyrosine kinase 797 Cluster-9280.0-1F TKL_CTR1-DRK-2 56 287 1 232 ITLGERIGLGSYGEVYHGDWHGTEVAVKKFLAQDVTNESLEEFRSEVRIMKKLRHPNIVLFMGAVTRPPNLSIVTEFLPRGSLYRLIHRPNNQLDERRRLRMALDAARGMNYLHNCTPVIVHRDLKSPNLLVDKNWVVKVGDFGLSKMKDSTFISSKSNAGTAEWMAPEVLRNEPSNEKCDVYSFGVILWELCTLQQPWAGMNPMQVVGAVGFQHRRLDIPDNVDPTIADII +t+geriG Gs+gevy+++w+G++vavk+fl qd+++e leefr+ev++mk+lrhpn+vlfmGavt+p++lsivteflprgsl+rl++r++++lderrrl++ald arG+nylh+++p+ivhrdlks+nllvdknw+vkv+dfGls++k +tf+ssks+aGt+ewmapevlrne+++ek+dvysfGvilwel+t+++pw ++n+mqvvgavgfq+rrl+ip++vdp++a++i ltigeriGqGsfgevyraewkGsdvavkvflkqdlseealeefrkevslmkrlrhpnvvlfmGavtkpqrlsivteflprgslfrllerkksklderrrlklaldvarGlnylhklsppivhrdlkssnllvdknwtvkvadfGlsrlkaetflsskstaGtpewmapevlrneaadeksdvysfGvilwelvtekipweelnamqvvgavgfqnrrleipkevdpkvasli 438.0 9.5e-134 TKL_CTR1-DRK-2 288 Cluster-9280.0-1F PF07714.14 56 287 1 239 ITLGERIGLGSYGEVYHGDWH------GTEVAVKKFlAQDVTNESLEEFRSEVRIMKKLRHPNIVLFMGAVTRPPNLSIVTEFLPRGSLYRLIHRP--NNQLDERRRLRMALDAARGMNYLHNCTpvIVHRDLKSPNLLVDKNWVVKVGDFGLSKMK--DSTFISSKSNAGTAEWMAPEVLRNEPSNEKCDVYSFGVILWELCT-LQQPWAGMNPMQVVGAVgFQHRRLDIPDNVDPTIADII ++lg+++G G++GeV++g ++ ++vavK++ ++ t+e+ eef +e++imkkl+hpniv ++g++t+ +l ivte+++ G+L + +++ +++l+ ++ l++al+ A+Gm+yL++ + +vHrdl + N L+++n vvk++DfGL++ d++ +++++ +WmapE+l+++ ++k Dv+sfGv+lwE++t ++p++g+++++v+ ++ +++rl+ p+++ +++++++ lelgkklGeGafGeVvegtlkgekekkevkvavKtl.keeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskk..lvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevlekl.kegkrlekpekcpeelyelm 205.1 7.5e-63 Protein tyrosine kinase 288 Cluster-9280.0-1F PF00069.22 58 261 3 204 LGERIGLGSYGEVYHGD--WHGTEVAVKKFLAQDVTNESLEEFRSEVRIMKKLRHPNIVLFMGAVTRPPNLSIVTEFLPRGSLYRLIHrPNNQLDERRRLRMALDAARGMNYLHNCTpvIVHRDLKSPNLLVDKNWVVKVGDFGLSKMKDSTFIsSKSNAGTAEWMAPEVLRNEPSNEKCDVYSFGVILWELCTLQQPWAGMNPMQ e++G Gs+G+Vy + + g +vAvKk+ ++ ++++ +++++E++i+kkl+hpniv ++++++++ +l +v+e+++ g+l +l++ + +l+e++ ++a ++g++ylH+ i+HrDlK+ N+L+d++ ++K++DFGl+k +s+ +s gt e++APEvl++++ +k+Dv+s Gvil+el t ++p++g + + kleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlls.rkgslseeeakkiakqilegleylHskg..iiHrDlKpeNiLidekgelKitDFGlakelesssk.ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgke 170.3 3.4e-52 Protein kinase domain 288 Cluster-9378.0-2R RLK-Pelle_LRR-V 1 128 103 236 ALQAARALEYLHEICQPPIVHQNFKSANILLDDGLAVRVSDSGLAPLLPSDSMTQL-----QGQGYGAPELE-SGSYTYQSDVYSFGVVMLELLTGRRSYDRSRPRAAQHLVRWAIPRLHDIDALSRMVDPSLN al+aaraleylhe+c+pp+vh+nfksanilld+ l +rvsd+Gla ll+s s +ql + +gy aPe+e sg+yt++sDvysfGvvmlelltgr+++D+srpr+ q+Lvrwa p+lhdidal++mvDp+l+ algaaraleylhevcsppvvhknfksanilldeelnprvsdcGlaallkssserqlsekllaslgysaPeveesgaytvksDvysfGvvmlelltgrkpfDssrprseqsLvrwatpqlhdidalekmvDpalk 205.8 5.7e-63 RLK-Pelle_LRR-V 128 Cluster-9378.0-2R PF00069.22 2 101 105 204 LQAARALEYLHEICqppIVHQNFKSANILLDDGLAVRVSDSGLAPLLPSDS-M-TQLQGQGYGAPEL-ESGSYTYQSDVYSFGVVMLELLTGRRSYDRSRPRA q +++leylH+ + i+H K++NiL+d+ ++++D Gla l s+s + ++ + Y APE+ ++ +y+ ++Dv+s Gv+++elltg+ + ++ + kqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgke 65.6 2.9e-20 Protein kinase domain 128 Cluster-9378.0-2R PF07714.14 1 101 110 214 ALQAARALEYLHEICqppIVHQNFKSANILLDDGLAVRVSDSGLAPLLPSDSMTQLQG-----QGYGAPE-LESGSYTYQSDVYSFGVVMLELLT-GRRSYDRSRPRA alq A+++eyL++ +vH++ + N+Ll+++ v++sD GLa + +d+ ++ ++ + apE l+++++t +sDv+sfGv++ E++t g+++y + +++ alqiAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsnee 61.9 3.8e-19 Protein tyrosine kinase 128 Cluster-9460.1-1R RLK-Pelle_RLCK-VI 86 342 3 267 LIGKGGYAEVYRGCLDGGQLVAIKRLTRGPlEERIGDFLSELGIMAHVNHPNTAKLIGYGVEG-GMYLVLELSPVGSLASLLHNSK----MLTWDIRYKVALGTAKGLLYLHEGCQRRIIHRDIKAANILLTEDYEPQICDFGLAKWLPERWTHLTLLKFEGTFGYLAPEFLMHGIVNEKTDVFAFGVLLLELITGRRALDYS----QQSLVMWAKPLLKKNKIRELVDPSLGDDYNSAQMNLMILAASLCVQQSCLRRPRMSQVL l+GkGg++evy+g+l+ g+lva+krl+++ ee+ +fl+el+i+++++h+n++kl+G++v++ g++lv+e+++ Gsl++lLh++k +l+W+ RykvA+G+ak+l ylHegc+rr+iHrD+ka+niLl+ed+epq++DFGlakwlpe+++hl+ ++eGtFGylape++mhG+vnektdv+afgv+lLelitgr+++d + ++slv+wakpll+++k++elvdp+l +++++ +++ ++laaslc+++s rrp++++vl lvGkGgasevykgkledgklvavkrlkkse.eekekeflaeleiisslshknvvkllGvcvdeeglllvyeylseGsleelLhgkkkkkelleWeeRykvAvGvakaleylHegcerrviHrDvkasniLlsedfepqlsDFGlakwlpekashllvkdveGtFGylapeyfmhGkvnektdvyafgvvlLelitgrkpidsksakgkeslvlwakplleekklkelvdpkleteadeeelerlvlaaslcirksakrrpslkevl 378.8 1.1e-115 RLK-Pelle_RLCK-VI 411 Cluster-9460.1-1R PF00069.22 86 301 6 220 LIGKGGYAEVYRGC-LDGGQLVAIKRLTRGPLEERIG-DFLSELGIMAHVNHPNTAKLIGYGV-EGGMYLVLELSPVGSLASLLHNSKMLTWDIRYKVALGTAKGLLYLHegcQRRIIHRDIKAANILLTEDYEPQICDFGLAKWLPERWThltLLKFEGTFGYLAPEFLMHGIVNEKTDVFAFGVLLLELITGRRALDYSQQSLVMW--AKPLLKKNKIR +G+G++++Vy+++ + g+ vA+K++ + +++ ++l+E+ i+++++hpn +l+++ + +ylvle+ + g+la+ll+++++l+ + k+a +++gl ylH +++iiHrD+K +NiL++e+ e +i+DFGlak l ++ + l +f gt YlAPE l + + +k+Dv++ Gv+l+el+tg+ + ++++ ++ ++ l k ki klGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylH...skgiiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkil 139.2 1e-42 Protein kinase domain 411 Cluster-9460.1-1R PF07714.14 86 341 6 256 LIGKGGYAEVYRGCLD-----GGQLVAIKRLTRGPLEERIGDFLSELGIMAHVNHPNTAKLIGYGV-EGGMYLVLELSPVGSLASLLHNS---KMLTWDIRYKVALGTAKGLLYLHEgcqRRIIHRDIKAANILLTEDYEPQICDFGLAKWLPERWTHLTLLKFEGTFGYLAPEFLMHGIVNEKTDVFAFGVLLLELIT-GRRAldYSQQSLVMWAKPLLKKNKireLVDPslgDDYNSAQMNLMilaaSLCVQQSCLRRPRMSQV +G+G ++eV++g l+ + va+K l+++ ee+ +fl+e+ im +++hpn kl+g + e+ +++v+e+ + G+L + L+++ + lt + +++al AkG+ yL++ ++++Hrd+ a N+Ll+e+ +i+DfGLa+ + ++ + + + + + ++apE l+++ +++k+Dv++fGvll E++t g++ y++ s ++ l ++++ l p ++ +++ ++lm + C++++ +Rp+++++ klGeGafGeVvegtlkgekekkevkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLes...kklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep..ypglsneevleklkegkr...lekp...ekcpeelyelm....kqCweedpeeRptfkel 133.2 6.5e-41 Protein tyrosine kinase 411 Cluster-9553.0-2R AGC_RSK-2 10 116 152 258 NTQSNSFVGTEEYIAPEIITGEGHSSAIDWWALGILLYEMLYGRTPFRGKNRQKTFANILRKDLTFPSSIPVSLAARQLINALLNRDPASRLGSTGGANEIKQHPFF +++snsfvGteey+aPeii+gegh+sa+dWWalGillye+lyg+tPf+gknr++t+an+l+k+l+fp++++vsl+ar+li+ ll++dp++rlgs+ ga+eik+hpff akrsnsfvGteeylaPeiikgeghgsavdWWalGillyellygktPfkgknreetlanvlkkelefpeeaavsleardlirkllekdpkkrlgskrgaaeikkhpff 177.9 2e-54 AGC_RSK-2 247 Cluster-9553.0-2R PF00069.22 10 116 151 264 NTQSNSFVGTEEYIAPEIITGEGHSSAIDWWALGILLYEMLYGRTPFRGKNRQKTFANILRK-----------DLTFPSSIPVSLAARQLINALLNRDPASRLGstggANEIKQHPFF +++ +sfvgt+eY+APE+++++++s+++D+W+lG++lye+l+g++pf+g++++++++++l++ ++++p +s a++l++ ll++dp +Rl+ a+e++qhp++ sskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRlt....aeellqhpyl 86.6 1.1e-26 Protein kinase domain 247 Cluster-9553.0-2R PF07714.14 20 100 170 250 EEYIAPEIITGEGHSSAIDWWALGILLYEMLY-GRTPFRGKNRQKTFANIlRKDLTFPSSIPVSLAARQLINALLNRDPASR +++apE+++ + +s+ D W+ G+ll+E++ g++p++g + +++++++ +++ + ++ + +l++ +++dp++R vkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevlekl.kegkrlekpekcpeelyelmkqCweedpeeR 29.4 3e-09 Protein tyrosine kinase 247 Cluster-9553.1-0R AGC_RSK-2 1 86 68 153 QTPTHVCLITDFCPGGELFAVLDKQPMKIFKEESARFYVAEVVISLEYLHCLGIIYRDLKPENILLQKDGHVVLTDFDLSFKTACQ +t ++vcl+++fcpgg+L++++++qp k+f+ee++rfy+aevv++leylh+lgi+yrdLkPen+l+++dGh++ltDfDLs+k++++ etekfvclvvefcpggdLhvlrerqpkkvfseeavrfyaaevvlaleylhalgivyrdLkPenvlvredGhimltDfDLslkasak 142.5 1.3e-43 AGC_RSK-2 110 Cluster-9553.1-0R PF00069.22 2 83 69 148 TPTHVCLITDFCPGGELFAVLDkqPMKIFKEESARFYVAEVVISLEYLHCLGIIYRDLKPENILLQKDGHVVLTDFDLSFKT ++++++l++++++ggel+ +l ++++ee a++++++++ +leylH+ gii+rDlKpeNiL++++g++ +tDF+l+ + ekdelylvleyveggeladlls..rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakel 80.9 6.1e-25 Protein kinase domain 110 Cluster-9553.1-0R PF07714.14 5 83 75 154 HVCLITDFCPGGELFAVLDKQ-PMKIFKEESARFYVAEVVISLEYLHCLGIIYRDLKPENILLQKDGHVVLTDFDLSFKT +++++t++++gG+L L k+ + ++ ++ +++++ +eyL+ ++ rdl N+Ll+++ +v ++Df L+ ++ pllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardi 41.3 7.2e-13 Protein tyrosine kinase 110 Cluster-962.0-2R RLK-Pelle_LRR-IX 1 98 174 271 YAVTGKITTKVDVFSFGVVLMEILTGLVALDEQRPEEKRYLAEWFWQIKSNKEILISSIDPALEAKEDIYESIYVIAELAGHCTARDPNHRPDMGHAV yavtg++ttkvdvfsfgvvlme++tg alde ++ee+ +l+ wf +++ +ke l + idp+le++e+ ++si+++aelaghctar+p++rpdmghav yavtgrvttkvdvfsfgvvlmelitgrkaldeskaeeevhlvtwfrrvlidkeklkkaidptleldeetlksiskvaelaghctarepkqrpdmghav 131.8 2.1e-40 RLK-Pelle_LRR-IX 202 Cluster-962.0-2R PF07714.14 5 99 181 258 GKITTKVDVFSFGVVLMEILT-GLVAldeqrpeekrylaewFWQIKSNKEILISSIDPALEAKEDIYESIYviaELAGHCTARDPNHRPDMGHAVN +k+t+k Dv+sfGv+l+Ei+t g ++++++++ + + + le++e++ e++y el +C ++dp++Rp++ + v+ kkftsksDvWsfGvllwEiftlgeep...............ypglsneevleklkegkrlekpekcpeely...elmkqCweedpeeRptfkelve 24.3 1.1e-07 Protein tyrosine kinase 202 Cluster-962.1-1R RLK-Pelle_LRR-IX 1 115 54 168 RHLVSLLGYSVEGNERLLVYEYVSQGALSRHLFRWKSLNLEPLSWTRRLCIALDVARAMEYLHSLAHQSFIHRDLKSSNILLDDNYRAKVADFGLVKLAPDQERSVATRLAGTFG r+lv+llgy++egnerllvyey++qg+ls+hlf++k +l+pl+w++rl ialdvar +eylhslahqsfihrdlk+snill+d++rakv+dfglvklapd++ sv+trlagtfg rnlvallgyclegnerllvyeympqgtlskhlfeykeeglkplewkkrlsialdvargveylhslahqsfihrdlkpsnillgddlrakvsdfglvklapdgklsvetrlagtfg 207.9 1.3e-63 RLK-Pelle_LRR-IX 115 Cluster-962.1-1R PF07714.14 2 105 62 160 HLVSLLGYSVEGNERLLVYEYVSQGALSRHLFRWksLNLEPLSWTRRLCIALDVARAMEYLHSlahQSFIHRDLKSSNILLDDNYRAKVADFGLVKLAPDQERS ++v+llg +++++ l+v eyv++G L+++L + + e+l+ ++ l++al++A++meyL+s ++++Hrdl + N+Ll++n +k++DfGL + ++++ nivkllgvctkeepllivteyvegGdLlkfLrkk..eekekltlkdllsfalqiAkGmeyLes...kklvHrdlaarNvLlsenkvvkisDfGLardiekddey 76.6 1.2e-23 Protein tyrosine kinase 115 Cluster-962.1-1R PF00069.22 2 110 59 157 HLVSLLGYSVEGNERLLVYEYVSQGALSRHLFRWKSLNLEplswtRRLCIALDVARAMEYLHslaHQSFIHRDLKSSNILLDDNYRAKVADFGLVKLAPDQERsvATRL ++v l+++ e +e++lv eyv++g l ++l r +sl+ e + ia +++++eylH ++++iHrDlK++NiL+d++ K++DFGl+k + +++ +t nivrlyevfeekdelylvleyveggeladllsrkgslsee.....eakkiakqilegleylH...skgiiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsf 66.4 1.6e-20 Protein kinase domain 115 Cluster-9692.0-2R NAK 3 200 83 265 HLDGTLFDIANAmkAKKEFFSTSDVLQIFRQLCAGLKHMHSFDPPYAHNDVKPGNVLVtyrkGQPPLAILMDFGSSRPARRQIRSRTEALQLQEWASEHCSAPFRAPELWDCPSLADIDERTDIWSLGCTLFAIMYGVSPFEyalgesgGSLQLAIVNAQIKWPkgPSPPYPDALHQFVTWMLQPQATVRPRIDDIII +ld+tL+d+++ +kke+f++ +vl+ifr++c++lkhmhs++Pp+ah+d+k++nvL+ gq++la+lmDfgs+r+ar++++sr eal++++++++h++a++raPelWd++s +dide++DiW+LGc+L+aimyg+spf+ G+++lai+n+++k+P +sp ypdal+q++++mLq+++ vrP+iddiii fldktLldvles..rkkeyfdeikvleifrdvcealkhmhslePpiahrdlkaenvLl....gqeglavlmDfgsartarkeldsreealaeedvirkhttaayraPelWdlysredidekvDiWaLGclLyaimygkspfd.......GesklailngklkiP..espkypdalrqlikdmLqaspavrPdiddiii 286.4 1.7e-87 NAK 285 Cluster-9692.0-2R PF00069.22 8 201 85 261 LFDIANamkaKKEFFSTSDVLQIFRQLCAGLKHMHSFDppYAHNDVKPGNVLVTyRKGQpplAILMDFGSSRPARRQIRsrtealqlqeWASEHCSAPFRAPELWdcpSLADIDERTDIWSLGCTLFAIMYGVSPFEYALGESGGSLQ-------LAIV-NAQIKWPKGPSPpyPDALHQFVTWMLQPQATVRPRIDDIIIH l+d+ + +k +s +++ +i++q+++gl+++Hs H D+Kp N+L++ +kg+ ++DFG ++ ++++ + s+ ++ ++APE+ + ++++ +D+WslG++l+ +++g pf+ g++ + + l i+ + + k+p+ + ++ + ++++++l+ + + R+ +++++ h ladlls....rkgslseeeakkiakqilegleylHskg..iiHrDlKpeNiLid.ekge...lKitDFGlakelesssk..........ltsfvgtreYlAPEvl...keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeasel..seeakdllkkllkkdpkkRltaeellqh 79.9 1.2e-24 Protein kinase domain 285 Cluster-9692.0-2R PF07714.14 12 199 89 257 ANAMKAK--KEFFSTSDVLQIFRQLCAGLKHMHSFDppYAHNDVKPGNVLVTYrkgqPPLAILMDFGSSRPARRQIRSrtealqlQEWASEHCSAPFRAPELWDCPSladIDERTDIWSLGCTLFAIMY-GVSPFEYALGESggSLQLAIVNAQIKWPKGpsppYPDALHQFVTWMLQPQATVRPRIDDII + +++k ke ++++d+l++ +q+++G+++++s + + H d+ NvL++ ++ + DfG +r +++ + ++ +++++ + apE ++ + + +++D+Ws G +l+ i+ g +p++ e+ l+ + +++ p+ p++l+++++ ++ +++ Rp++++++ lkfLrkkeekekltlkdllsfalqiAkGmeyLeskk..lvHrdlaarNvLlse....nkvvkisDfGLardiekddey.......kkkeeaklpvkWmapEslkekk...ftsksDvWsfGvllwEiftlgeepypglsnee..vleklkegkrlekpek....cpeelyelmkqCweedpeeRptfkelv 38.7 4.4e-12 Protein tyrosine kinase 285 Cluster-9694.0-2F RLK-Pelle_LRR-Xb-1 1 165 17 180 LKDGSIVAIKKLIHISGQGDREFTAEMETIGKIKHRNLVPLLGYCKVGEERLLVYEYMKYGSLEDVLHDRKKIGIKLNWAARRKIAIGAARGLAFLHHNCTPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSvSTLAGTPGYVPPEYYQSFRCSTK lkdgs vaikkl + + qg+ref+ae+et+gk+kh+nlvpllGyc++geerlLvyey+++gsL+d+Lh++++ +l+W++r kia gaarglaflh++c+phiihrd+kssn+Llde++earv+DfG+arl+sa++th+s ++laGt+GY+pPey+qs+r+++k lkdgskvaikklkkellqgerefkaevetlgkvkhenlvpllGyciageerlLvyeylengsLddwLhekedkaealdWekrlkiakgaarglaflheeckphiihrdikssniLldeefearvaDfGlarlisaaethvs.telaGtlGYipPeygqslratlk 280.5 8.8e-86 RLK-Pelle_LRR-Xb-1 165 Cluster-9694.0-2F PF00069.22 2 158 22 170 KDGSIVAIKKLIHISGQGDR--EFTAEMETIGKIKHRNLVPLLGYCKVGEERLLVYEYMKYGSLEDVLHDRKKIGIKlnwaARRKIAIGAARGLAFLHHNCtphIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDThlsVSTLAGTPGYVPPEYYQ ++g ivA+Kk+ + + + ++ ++++E++ + k+kh+n+v l+++++ +e++lv ey++ g+l+d+l++++++ + +kia ++gl++lH+++ iiHrD+K++N+L+de+ e +++DFG+a+ ++ + +++ gt+ Y++PE + etgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslsee....eakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlk 106.9 7.6e-33 Protein kinase domain 165 Cluster-9694.0-2F PF07714.14 6 164 30 185 IVAIKKLIHISG-QGDREFTAEMETIGKIKHRNLVPLLGYCKVGEERLLVYEYMKYGSLEDVLHDRKKiGIKLNWAARRKIAIGAARGLAFLHHNctpHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFRCST va+K+l + + + +ef+ e++++ k+kh+n+v llg c +e+ l+v ey+++G+L++ L+++++ kl+ ++a+ A+G+++L+++ +++Hrd+ + NvLl+en +++sDfG+ar ++ +d+ + ++ +++pE ++ ++++ kvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkee.kekltlkdllsfalqiAkGmeyLesk...klvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkfts 102.1 2e-31 Protein tyrosine kinase 165 Cluster-9699.7-0R AGC-Pl 202 463 1 257 FEIMRVIGKGAFGKVFQVRKKGGSGTdgdgsFAMKVMRKETIIKNNHVDYMRAERDILTKVVHPFIVPLRYSFQTKSKLYLILDFINGGHLFYHLYRQGIFSEDQARVYTAEIVSAVSHLHKNGIMHRDLKPENVLMDADGHVMLTDFGLAKEIDESSRSNSMCGTTEYMAPEILLARGHDKNADWWSVGILLYEMLSGQPPFTHPNRKKLQEKIINEKVKLPPRLSSEVHSLLKGLLHKDPLKRLGSGPKGADEIKQHKWF fe+++v+g+gafgkvfqvrkkg s +amkvmrke i+++nh +y++aerdiltkvvhpfiv lrysfqtksklyl+ldfingghlf++lyrqg+f+ed ar+ytaeiv+av+hlh++gi+hrdlkpen+l+dadghvmltdfglake++e srsns+cgt+eymapei+ a+ghdk adwwsvgillyeml+g+ppf++ n++klq+ki+++k+klp lss+++sllkgll+kdp krlgsgp+g++eik+hkwf fellkvvgqgafgkvfqvrkkgtsei.....yamkvmrkekileknhaeylkaerdiltkvvhpfivqlrysfqtksklylvldfingghlffqlyrqglfredlarlytaeivlavahlhekgiihrdlkpenilldadghvmltdfglakevkedsrsnslcgtveymapeivkakghdkaadwwsvgillyemltgkppfvaknkqklqqkivkdkiklpkflssdaksllkgllqkdpekrlgsgpsgseeikkhkwf 478.2 4.4e-146 AGC-Pl 569 Cluster-9699.7-0R PF00069.22 202 463 1 264 FEIMRVIGKGAFGKVFQVRKKggsgtDGDGSFAMKVMRKETIIKNNHvDYMRAERDILTKVVHPFIVPLRYSFQTKSKLYLILDFINGGHLFYHLYRQGIFSEDQARVYTAEIVSAVSHLHKNGIMHRDLKPENVLMDADGHVMLTDFGLAKEIDESSRSNSMCGTTEYMAPEILLARGHDKNADWWSVGILLYEMLSGQPPFTHPNRKKLQEKIINE-------------KVKLPPRLSSEVHSLLKGLLHKDPLKRLGsgpkgADEIKQHKWF +e ++ +G+G+fGkV+++++k + + +A+K+++ke + k+++ + +++E il k+ hp+iv l ++f++k++lyl+l++++gg+l+ +l r+g++se++a+ ++++i++++++lH++gi+HrDlKpeN+L+d +g++++tDFGlake+++ss+ +s++gt eY+APE+l +++++k++D+Ws+G++lye+l+g+ppf + ++k+ +ek++++ k++ + ls+e+ +llk ll+kdp kRl+ a+e++qh+++ yekleklGeGsfGkVykavek.....etgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRlt.....aeellqhpyl 249.0 3.3e-76 Protein kinase domain 569 Cluster-9699.7-0R PF07714.14 203 446 2 250 EIMRVIGKGAFGKVFQVRKKGgSGTDGDGSFAMKVMrKETIIKNNHVDYMRaERDILTKVVHPFIVPLRYSFQTKSKLYLILDFINGGHLFYHLYRQ---GIFSEDQARVYTAEIVSAVSHLHKNGIMHRDLKPENVLMDADGHVMLTDFGLAKEI---DESSRSNSMCGTTEYMAPEILLARGHDKNADWWSVGILLYEMLS-GQPPFTHPNRKKLQEKIINE-KVKLPPRLSSEVHSLLKGLLHKDPLKR e+ + +G+GafG+V++ + kg + ++ + + a+K++ ke+ ++++ + ++ e +i++k+ hp iv l +++l++++++++gG+L +L ++ ++ ++ ++++i +++++L+++ ++Hrdl NvL++ + +v ++DfGLa++i de +++++ ++mapE+l ++ +++D Ws G+ll+E+++ g+ p+++ + +++ ek+ ++ +++ p ++e+++l+k +++dp +R elgkklGeGafGeVvegtlkg.ekekkevkvavKtl.keeateeekeefle.eakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeR 134.0 3.7e-41 Protein tyrosine kinase 569 Cluster-9699.8-1R AGC-Pl 37 161 133 257 NSSRQVMLTDFGLAKEIDESSRSNSMCGTTEYMAPEILLARGHDKNADWWSVGILLYEMLSGQPPFTHPNRKKLQEKIINEKVKLPPRLSSEVHSLLKGLLHKDPLKRLGSGPKGADEIKQHKWF ++ +vmltdfglake++e srsns+cgt+eymapei+ a+ghdk adwwsvgillyeml+g+ppf++ n++klq+ki+++k+klp lss+++sllkgll+kdp krlgsgp+g++eik+hkwf dadghvmltdfglakevkedsrsnslcgtveymapeivkakghdkaadwwsvgillyemltgkppfvaknkqklqqkivkdkiklpkflssdaksllkgllqkdpekrlgsgpsgseeikkhkwf 208.5 8.8e-64 AGC-Pl 267 Cluster-9699.8-1R PF00069.22 38 161 133 264 SSRQVMLTDFGLAKEIDESSRSNSMCGTTEYMAPEILLARGHDKNADWWSVGILLYEMLSGQPPFTHPNRKKLQEKIINE-------------KVKLPPRLSSEVHSLLKGLLHKDPLKRLGsgpkgADEIKQHKWF +++++++tDFGlake+++ss+ +s++gt eY+APE+l +++++k++D+Ws+G++lye+l+g+ppf + ++k+ +ek++++ k++ + ls+e+ +llk ll+kdp kRl+ a+e++qh+++ ekgelKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRlt.....aeellqhpyl 112.3 1.6e-34 Protein kinase domain 267 Cluster-9699.8-1R PF07714.14 38 144 139 250 SSRQVMLTDFGLAKEI---DESSRSNSMCGTTEYMAPEILLARGHDKNADWWSVGILLYEMLS-GQPPFTHPNRKKLQEKIINE-KVKLPPRLSSEVHSLLKGLLHKDPLKR ++++v ++DfGLa++i de +++++ ++mapE+l ++ +++D Ws G+ll+E+++ g+ p+++ + +++ ek+ ++ +++ p ++e+++l+k +++dp +R enkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevleklkegkrlekpekcpeelyelmkqCweedpeeR 55.4 3.5e-17 Protein tyrosine kinase 267 Cluster-9699.9-0R AGC-Pl 202 401 1 195 FEIMRVIGKGAFGKVFQVRKKGGSGTdgdgsFAMKVMRKETIIKNNHVDYMRAERDILTKVVHPFIVPLRYSFQTKSKLYLILDFINGGHLFYHLYRQGIFSEDQARVYTAEIVSAVSHLHKNGIMHRDLKPENVLMDADGHVMLTDFGLAKEIDESSRSNSMCGTTEYMAPEILLARGHDKNADWWSVGILLYEMLSGQ fe+++v+g+gafgkvfqvrkkg s +amkvmrke i+++nh +y++aerdiltkvvhpfiv lrysfqtksklyl+ldfingghlf++lyrqg+f+ed ar+ytaeiv+av+hlh++gi+hrdlkpen+l+dadghvmltdfglake++e srsns+cgt+eymapei+ a+ghdk adwwsvgillyeml+g+ fellkvvgqgafgkvfqvrkkgtsei.....yamkvmrkekileknhaeylkaerdiltkvvhpfivqlrysfqtksklylvldfingghlffqlyrqglfredlarlytaeivlavahlhekgiihrdlkpenilldadghvmltdfglakevkedsrsnslcgtveymapeivkakghdkaadwwsvgillyemltgk 376.1 6.3e-115 AGC-Pl 443 Cluster-9699.9-0R PF00069.22 202 401 1 194 FEIMRVIGKGAFGKVFQVRKKggsgtDGDGSFAMKVMRKETIIKNNHvDYMRAERDILTKVVHPFIVPLRYSFQTKSKLYLILDFINGGHLFYHLYRQGIFSEDQARVYTAEIVSAVSHLHKNGIMHRDLKPENVLMDADGHVMLTDFGLAKEIDESSRSNSMCGTTEYMAPEILLARGHDKNADWWSVGILLYEMLSGQ +e ++ +G+G+fGkV+++++k + + +A+K+++ke + k+++ + +++E il k+ hp+iv l ++f++k++lyl+l++++gg+l+ +l r+g++se++a+ ++++i++++++lH++gi+HrDlKpeN+L+d +g++++tDFGlake+++ss+ +s++gt eY+APE+l +++++k++D+Ws+G++lye+l+g+ yekleklGeGsfGkVykavek.....etgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgk 208.8 5.8e-64 Protein kinase domain 443 Cluster-9699.9-0R PF07714.14 203 400 2 203 EIMRVIGKGAFGKVFQVRKKGgSGTDGDGSFAMKVMrKETIIKNNHVDYMRaERDILTKVVHPFIVPLRYSFQTKSKLYLILDFINGGHLFYHLYRQ---GIFSEDQARVYTAEIVSAVSHLHKNGIMHRDLKPENVLMDADGHVMLTDFGLAKEI---DESSRSNSMCGTTEYMAPEILLARGHDKNADWWSVGILLYEMLS-G e+ + +G+GafG+V++ + kg + ++ + + a+K++ ke+ ++++ + ++ e +i++k+ hp iv l +++l++++++++gG+L +L ++ ++ ++ ++++i +++++L+++ ++Hrdl NvL++ + +v ++DfGLa++i de +++++ ++mapE+l ++ +++D Ws G+ll+E+++ g elgkklGeGafGeVvegtlkg.ekekkevkvavKtl.keeateeekeefle.eakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlg 118.3 2.3e-36 Protein tyrosine kinase 443 Cluster-9701.0-0R RLK-Pelle_SD-2b 3 214 20 233 STIIAVKKLDRVaQDTDKEFRTEVSVIGQTHHKNLVRLLGFCEDGPHRLLVYEYMNNGTLAGFLF---GGLKPNWQKRTHIAMGIARGLAYLHEECSTQIIHCDIKPQNILLDENYNARISDFGLAKLLMMNQSRTLTNIRGTKGYVAPEWFRNTQVTAKVDVYSFGVLLLEIVTCRKSLMDVESGDGENPILTDWVWDRFVERRVDTLVENDVE +t +avKkl++v + ++kefr+evsvig+++h nLvrllGfc++g +rllvyey++ng+L+ +lf +w++r++ia+g+ArglayLHeec+++iihcdikp+niLlde+++++i+dfGlakll +qsr+lt++rGt+gY+apew+ n+++t+kvDvYs+Gv+lle+v++r+++++ es + e+ +l+ ++ +++ e++v +lv++++e etkvavKklekv.eqgekefraevsvigsiqhvnLvrllGfcsegekrllvyeyvengsLdkllfkkkskkvlewktrlkialgvArglayLHeecrekiihcdikpeniLldekfepkiadfGlakllkrdqsrvlttvrGtrgYlapewisnlaitekvDvYsyGvvllelvsgrrnveekeseeeesvllvklaaekleegevaelvdarle 297.6 6e-91 RLK-Pelle_SD-2b 215 Cluster-9701.0-0R PF00069.22 4 180 25 198 TIIAVKKLDRVAQDTDKE--FRTEVSVIGQTHHKNLVRLLGFCEDGPHRLLVYEYMNNGTLAGFLFGGLKPNWQKRTHIAMGIARGLAYLHEECstqIIHCDIKPQNILLDENYNARISDFGLAKLLMMNQSrtLTNIRGTKGYVAPEWFRNTQVTAKVDVYSFGVLLLEIVTCRKSLM i+AvKk+++ ++ +ke +++E++++ +++h+n+vrl++++e+ +++lv ey+++g+la +l + + ++ +ia i++gl+ylH+++ iiH+D+Kp+NiL+de+ + +i+DFGlak l +++ lt++ gt+ Y+APE+ +++++++kvDv+s Gv+l+e++t + + kivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllsrkgslseeeakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfs 155.9 8.2e-48 Protein kinase domain 215 Cluster-9701.0-0R PF07714.14 4 181 29 209 TIIAVKKLDRVAQDT-DKEFRTEVSVIGQTHHKNLVRLLGFCEDGPHRLLVYEYMNNGTLAGFLFGG---LKPNWQKRTHIAMGIARGLAYLHEEcstQIIHCDIKPQNILLDENYNARISDFGLAKLL-MMNQSRTLTNIRGTKGYVAPEWFRNTQVTAKVDVYSFGVLLLEIVT-CRKSLMD + +avK+l++ a+++ +ef +e++++ +++h+n+v+llg+c ++ + l+v ey+++G+L fL k + ++ ++a+ iA+G++yL+++ +++H d+ +N+Ll+en ++isDfGLa+ + +++ ++ ++ + ++apE ++++++t k Dv+sfGvll Ei+t +++++ + vkvavKtlkeeateeekeefleeakimkklkhpnivkllgvctkeepllivteyvegGdLlkfLrkkeekekltlkdllsfalqiAkGmeyLesk...klvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypg 135.8 1e-41 Protein tyrosine kinase 215 Cluster-9705.0-1R CAMK_CAMKL-CHK1 1 78 179 256 DGAAADVWSCGVILYVLMAGYLPFDEKDLPTLYIKINAAEFSCPFWFSPASVSLLRKILDHNPETRIKIEGIKTDPWF dga+advWscGvil+vl+agylPf++++l +ly ki++aef++p w+s+ +l++++ld npetri+ie i++++Wf dgakadvWscGvilfvllagylPfedenlvelyrkilkaefklpkwlskeakklisrlldpnpetritieeileeeWf 106.9 8.9e-33 CAMK_CAMKL-CHK1 154 Cluster-9705.0-1R PF00069.22 3 78 176 264 AAADVWSCGVILYVLMAGYLPFDEKDL-PTLYIKINA----------AEFSCPFW--FSPASVSLLRKILDHNPETRIKIEGIKTDPWF +++DvWs+Gvily l++g pf +++ + + +++ +++ p + +s+ +ll+k+l+ +p++R+ +e ++ +p++ kkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 36.5 2.2e-11 Protein kinase domain 154 Cluster-9708.0-1F RLK-Pelle_LRR-XI-1 1 163 105 266 AAKGIAYLHHDCSPPIIHRDIKSTNILLTEDYEAKIADFGVAKLAEVSPRGSECSCFAGTHGYMAPELAYSFKITEKSDVYSFGVVLLELVTGRKPVEEAYGEGKDIVYWVSTSlnDLNNVVEVLDPKV-VSDLVKDDMIKFLKIASLCTTKLPNLRPSMKEVV +A+g+aYlhhdcsppi+HrD+ks+niLL +++eak+adfg+ak+ + + + +++s++ag++GY+aPe+ay+ k+teksDvYSfGvvlLelvtg+kpv+e++ge++div wv+++ + ++v e+lD+k+ vs+ +++m+k lk+a lct++ p+ RP+m+evv vAegLaYlhhdcsppivHrDvkssniLLdsefeakvadfglakvldekkeseslsavagsyGYiaPeyaytlkvteksDvYSfGvvlLelvtgkkpvdeefgesvdivkwvaek..kkekveeilDeklavseaaeeemlkvlkvallctsespeeRPtmrevv 221.3 9.9e-68 RLK-Pelle_LRR-XI-1 205 Cluster-9708.0-1F PF00069.22 2 164 108 260 AKGIAYLHHDCsppIIHRDIKSTNILLTEDYEAKIADFGVAKLAEVSPRgseCSCFAGTHGYMAPELAYSFKITEKSDVYSFGVVLLELVTGRKPVEEAYGEGKdiVYWVSTSLNDLNNVVEvlDPKVVSDLVKDDMIKFLKIASLCTTKLPNLRPSMKEVVK ++g++ylH+ + iiHrD+K+ NiL++e+ e Ki+DFG+ak +e s + + f gt+ Y+APE+ + ++++k+Dv+s Gv+l+el+tg+ p ++ g+ k v+ + l + ++++ + k+ ++ ++ +++++ + + +k p+ R++++e+++ legleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkek..vekeldqlekilkilg..etkeklpeaselseeakdllkkllkkdpkkRltaeellq 103.4 8.7e-32 Protein kinase domain 205 Cluster-9708.0-1F PF07714.14 2 166 114 260 AKGIAYLHHDCsppIIHRDIKSTNILLTEDYEAKIADFGVAKLAEVSPRGSECSCFAGTHGYMAPELAYSFKITEKSDVYSFGVVLLELVT-GRKPveeaygegkdivywvSTSLnDLNNVVEVLDPKVVSDLVKDDMIKFLKIASLCTTKLPNLRPSMKEVVKML AkG++yL++ ++Hrd+ + N+Ll+e+ +ki+DfG+a+ e + + ++ + +mapE + k+t+ksDv+sfGv+l E++t g++p ++l + ++v+e l+ + + ++ ++ ++ + C ++ p+ Rp++ke+v+ l AkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeep...............ypgl.sneevleklkegkrlekpekcpeelyelmkqCweedpeeRptfkelvekl 84.6 4.4e-26 Protein tyrosine kinase 205 Cluster-9768.0-2F CAMK_CDPK 1 150 110 259 LSVVAFCHSQGVVHRDLKPENFLYISKDENSRLKLIDFGLSDIVRPDEKLNDIVGSAYYVAPEVLHRSYSTEADVWSIGVVAYILLCGSRPFWARTESGIFRAVLKGNPSFDEAPWPSVSSEAKDFIKLLLQKDPRKRMTSAQALCHPWI l+vva+cHs+gvvhrDlKPeNfl+ sk+e+++lk+iDFGls++v+++e+l+divGs+yyvaPEvl+rsy++eadvWs+Gv++yillcg++pfwa+te++if+avlk++++f+++pw+svs+eakd+++ lL+kdp+kR+t +q+L hpW+ levvaacHskgvvhrDlKPeNflltskeedaplkaiDFGlsvfvkegerledivGspyyvaPEvlkrsygkeadvWsaGvilyillcgvppfwaeteeeifkavlkaeldfksepwksvseeakdlvrrlLekdpkkRltaeqvLehpWl 244.1 1.4e-74 CAMK_CDPK 197 Cluster-9768.0-2F PF00069.22 3 150 110 264 VVAFCHSQGVVHRDLKPENFLYIsKDENsrLKLIDFGLSDIVRPDEKLNDIVGSAYYVAPEVL-HRSYSTEADVWSIGVVAYILLCGSRPFWARTESGIFRAVLKG---------NPSFDEAPWPSVSSEAKDFIKLLLQKDPRKRMTSAQALCHPWI ++++Hs+g++HrDlKpeN+L+ ++++ lK++DFGl+ ++ ++kl+++vg+ +Y+APEvl +++ys+++DvWs+Gv+ y ll+g pf++++++ +++ l+ + +++ + + ++s+eakd++k ll+kdp+kR+t +++l hp++ gleylHskgiiHrDlKpeNiLid.ekge..lKitDFGlakelessskltsfvgtreYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaselseeakdllkkllkkdpkkRltaeellqhpyl 150.8 3e-46 Protein kinase domain 197 Cluster-9768.0-2F PF07714.14 5 142 118 254 AFCHSQGVVHRDLKPENFLYISkdeNSRLKLIDFGLSDIVRPDEKL---NDIVGSAYYVAPEVLH-RSYSTEADVWSIGVVAYILLC-GSRPFWARTESGIFRAVLKGNPsfdEAPWPSVSSEAKDFIKLLLQKDPRKRMTSA ++ +s+ +vHrdl N L + n+ k+ DfGL++ ++ d++ ++ + ++apE+l+ +++++++DvWs Gv+ + +++ g++p++ +++ +++++ +g+ + ++++e ++++k +++dp++R t + eyLeskklvHrdlaarNvLlse...nkvvkisDfGLardiekddeykkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgeepypglsneevleklkegkr...lekpekcpeelyelmkqCweedpeeRptfk 56.1 2.2e-17 Protein tyrosine kinase 197 Cluster-984.0-1F TKL-Pl-4 74 145 2 77 ESKVASGSFGDLYKGTYCSQEVAIKILMP----ERVNVDMLKEFSQEVFIMRKVRHKNVVQFIGACTRPPNLCIVT ++k+a+G++g+lykg+y++q+va+Kil + e+ + ++ kef+qev +++k++Hknvv+figact++p+lcivt gekiaeGalgklykgkykeqdvavKileageekeeeaaelekefkqevavlsklkHknvvkfigactkepalcivt 85.2 4.6e-26 TKL-Pl-4 154 Cluster-984.0-1F PF07714.14 71 145 1 80 LKFESKVASGSFGDLYKGTYC------SQEVAIKILmPERVNVDMLKEFSQEVFIMRKVRHKNVVQFIGACTRPPNLCIVT l++++k+++G+fG+ ++gt+ +++va+K+l e+ + + +ef +e+ im+k++h+n+v+++g+ct+ +l+ivt lelgkklGeGafGeVvegtlkgekekkevkvavKtl.keeateeekeefleeakimkklkhpnivkllgvctkeepllivt 49.5 2.2e-15 Protein tyrosine kinase 154 Cluster-984.0-1F PF00069.22 73 145 3 77 FESKVASGSFGDLYKGT--YCSQEVAIKILMPERVNVDMLKEFSQEVFIMRKVRHKNVVQFIGACTRPPNLCIVT ++k+ +GsfG yk++ +++vA+K++ e+ + ++ k++ +E+ i++k++h+n+v+++++++++ +l++v+ kleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvl 37.7 9.6e-12 Protein kinase domain 154