# emapper version: emapper-hotfix-numpy-45-g001c4bf emapper DB: 2.0 # command: ./emapper.py -m diamond --seed_ortholog_evalue 0.00001 --data_dir /home/bayegy/Databases/emapper/data_dir2.0.1/ --cpu 30 --temp_dir /media/bayegy/disk2/bayegy/pipeline_demos/binning/share_mix/Bin_all/emapper//MAG.T1.5/_tmp -i /media/bayegy/disk2/bayegy/pipeline_demos/binning/share_mix/Bin_all/Bin_prokka//MAG.T1.5/MAG.T1.5.faa -o /media/bayegy/disk2/bayegy/pipeline_demos/binning/share_mix/Bin_all/emapper//MAG.T1.5/MAG.T1.5 --usemem --override # time: Sat Jun 6 06:49:43 2026 #query_name seed_eggNOG_ortholog seed_ortholog_evalue seed_ortholog_score best_tax_level Preferred_name GOs EC KEGG_ko KEGG_Pathway KEGG_Module KEGG_Reaction KEGG_rclass BRITE KEGG_TC CAZy BiGG_Reaction taxonomic scope eggNOG OGs best eggNOG OG COG Functional cat. eggNOG free text desc. MAG.T1.5_00003 330214.NIDE2873 7.6e-78 297.4 Bacteria wapR ko:K12987,ko:K12988 ko00000,ko01000,ko01003,ko01005 GT2 Bacteria COG1215@1,COG1215@2 NA|NA|NA M transferase activity, transferring glycosyl groups MAG.T1.5_00004 1283299.AUKG01000002_gene4029 3.3e-94 352.1 Actinobacteria 2.6.1.87 ko:K07806,ko:K21337 ko00520,ko00523,ko01130,ko01503,ko02020,map00520,map00523,map01130,map01503,map02020 M00721,M00761 R07659,R11467 RC00006,RC01514,RC03445 ko00000,ko00001,ko00002,ko01000,ko01005,ko01007 Bacteria 2GKD7@201174,COG0399@1,COG0399@2 NA|NA|NA E Belongs to the DegT DnrJ EryC1 family MAG.T1.5_00006 330214.NIDE0285 2.1e-68 265.0 Bacteria ko:K07063 ko00000 Bacteria COG1569@1,COG1569@2 NA|NA|NA S PIN domain MAG.T1.5_00010 330214.NIDE0281 1.1e-60 239.2 Nitrospirae dksA ko:K06204 ko02026,map02026 ko00000,ko00001,ko03000,ko03009,ko03021 Bacteria 3J0TH@40117,COG1734@1,COG1734@2 NA|NA|NA T Prokaryotic dksA/traR C4-type zinc finger MAG.T1.5_00011 330214.NIDE0280 6.5e-105 386.7 Nitrospirae recR GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 ko:K06187 ko03440,map03440 ko00000,ko00001,ko03400 Bacteria 3J0KB@40117,COG0353@1,COG0353@2 NA|NA|NA L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO MAG.T1.5_00012 330214.NIDE0279 1.1e-45 189.1 Nitrospirae ybaB ko:K09747 ko00000 Bacteria 3J1EY@40117,COG0718@1,COG0718@2 NA|NA|NA L Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection MAG.T1.5_00013 330214.NIDE0278 3.4e-261 907.5 Nitrospirae dnaX 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 3J0DD@40117,COG2812@1,COG2812@2 NA|NA|NA L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity MAG.T1.5_00015 330214.NIDE0277 0.0 1150.6 Bacteria ko:K07289 ko00000 Bacteria COG2982@1,COG2982@2 NA|NA|NA M Protein involved in outer membrane biogenesis MAG.T1.5_00016 330214.NIDE0276 3e-126 458.0 Nitrospirae ko:K03442,ko:K22044 ko00000,ko02000 1.A.23.2,1.A.23.3 Bacteria 3J0R7@40117,COG3264@1,COG3264@2 NA|NA|NA M Mechanosensitive ion channel MAG.T1.5_00017 330214.NIDE0275 4.2e-75 287.7 Bacteria rmuC ko:K09760 ko00000 Bacteria COG1322@1,COG1322@2 NA|NA|NA S DNA recombination MAG.T1.5_00019 330214.NIDE0274 5.1e-211 740.7 Bacteria ko:K02557,ko:K03286 ko02030,ko02040,map02030,map02040 ko00000,ko00001,ko02000,ko02035 1.A.30.1,1.B.6 Bacteria COG2885@1,COG2885@2 NA|NA|NA M chlorophyll binding MAG.T1.5_00020 330214.NIDE0273 7.3e-68 263.5 Bacteria Bacteria COG1100@1,COG1100@2 NA|NA|NA S GTP binding MAG.T1.5_00021 330214.NIDE0271 1.9e-253 881.7 Bacteria Bacteria COG3829@1,COG3829@2 NA|NA|NA T transcription factor binding MAG.T1.5_00022 330214.NIDE0270 9.6e-31 139.8 Bacteria Bacteria COG2197@1,COG2197@2 NA|NA|NA K response regulator MAG.T1.5_00023 330214.NIDE0268 6.4e-191 673.3 Bacteria Bacteria COG3137@1,COG3137@2 NA|NA|NA MAG.T1.5_00024 330214.NIDE0267 1.3e-59 235.7 Nitrospirae mscL GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 ko:K03282 ko00000,ko02000 1.A.22.1 Bacteria 3J19K@40117,COG1970@1,COG1970@2 NA|NA|NA M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell MAG.T1.5_00025 330214.NIDE0266 9.1e-98 364.0 Bacteria motB ko:K02557,ko:K21471 ko02030,ko02040,map02030,map02040 ko00000,ko00001,ko01000,ko01002,ko01011,ko02000,ko02035 1.A.30.1 Bacteria COG1360@1,COG1360@2,COG4942@1,COG4942@2 NA|NA|NA N Flagellar Motor Protein MAG.T1.5_00026 330214.NIDE0265 1.9e-105 389.8 Bacteria ebh 2.1.1.80,3.1.1.61 ko:K02557,ko:K07484,ko:K13924,ko:K21471 ko02020,ko02030,ko02040,map02020,map02030,map02040 M00506 ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko02000,ko02022,ko02035 1.A.30.1 Bacteria COG1360@1,COG1360@2,COG4372@1,COG4372@2 NA|NA|NA Q Transposase MAG.T1.5_00027 330214.NIDE0264 2.2e-179 635.2 Bacteria ko:K01999 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria COG0683@1,COG0683@2 NA|NA|NA E ABC-type branched-chain amino acid transport systems, periplasmic component MAG.T1.5_00028 330214.NIDE0263 1.5e-155 555.8 Bacteria Bacteria COG1413@1,COG1413@2 NA|NA|NA C deoxyhypusine monooxygenase activity MAG.T1.5_00030 330214.NIDE0262 3.2e-213 747.7 Nitrospirae tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 ko:K03545 ko00000 Bacteria 3J12E@40117,COG0544@1,COG0544@2 NA|NA|NA O Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase MAG.T1.5_00031 330214.NIDE0261 8e-114 416.4 Nitrospirae clpP GO:0000502,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0010498,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017171,GO:0019538,GO:0019899,GO:0030163,GO:0031597,GO:0032991,GO:0042623,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0050896,GO:0051117,GO:0051603,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 ko00000,ko00001,ko01000,ko01002 Bacteria 3J0A3@40117,COG0740@1,COG0740@2 NA|NA|NA O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins MAG.T1.5_00032 330214.NIDE0260 1.7e-232 811.6 Nitrospirae clpX GO:0000166,GO:0000502,GO:0002020,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009376,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019899,GO:0019904,GO:0030163,GO:0030164,GO:0030312,GO:0030554,GO:0031333,GO:0031597,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0043335,GO:0044087,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0051704,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0097718,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 ko:K03544 ko04112,map04112 ko00000,ko00001,ko03110 Bacteria 3J0AM@40117,COG1219@1,COG1219@2 NA|NA|NA O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP MAG.T1.5_00033 330214.NIDE0258 4.2e-84 317.4 Bacteria ko:K02676 ko00000,ko02035,ko02044 Bacteria COG3215@1,COG3215@2 NA|NA|NA NU PilZ domain MAG.T1.5_00034 330214.NIDE0257 2.3e-74 285.0 Bacteria ko:K02676 ko00000,ko02035,ko02044 Bacteria COG3215@1,COG3215@2 NA|NA|NA NU PilZ domain MAG.T1.5_00035 330214.NIDE0256 6.6e-18 97.8 Bacteria cpeZ ko:K05386 ko00196,ko01100,map00196,map01100 ko00000,ko00001,ko00194 Bacteria COG1413@1,COG1413@2 NA|NA|NA C deoxyhypusine monooxygenase activity MAG.T1.5_00036 330214.NIDE0255 2.7e-112 411.8 Bacteria tatA ko:K03116 ko03060,ko03070,map03060,map03070 M00336 ko00000,ko00001,ko00002,ko02044 2.A.64 Bacteria COG1826@1,COG1826@2 NA|NA|NA U protein secretion MAG.T1.5_00037 330214.NIDE0254 3.2e-191 674.5 Bacteria 3.4.11.9 ko:K01262 ko00000,ko01000,ko01002 Bacteria COG0006@1,COG0006@2 NA|NA|NA E proline dipeptidase activity MAG.T1.5_00039 1283300.ATXB01000001_gene259 2.5e-11 75.5 Bacteria Bacteria 2DGQ2@1,2ZWWE@2 NA|NA|NA MAG.T1.5_00040 330214.NIDE0251 3.7e-121 441.0 Nitrospirae puuD GO:0003674,GO:0003824,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0033969,GO:0034641,GO:0042402,GO:0044106,GO:0044237,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901575 3.5.1.94,4.1.3.27 ko:K01658,ko:K07010,ko:K09473 ko00330,ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00330,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023,M00136 R00985,R00986,R07419 RC00010,RC00090,RC00096,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000,ko01002 Bacteria 3J0PV@40117,COG2071@1,COG2071@2 NA|NA|NA S Peptidase C26 MAG.T1.5_00041 330214.NIDE0250 1.2e-234 818.9 Nitrospirae yeeF ko:K03294 ko00000 2.A.3.2 Bacteria 3J0ZY@40117,COG0531@1,COG0531@2 NA|NA|NA E Amino acid permease MAG.T1.5_00044 330214.NIDE0246 1.8e-193 681.8 Nitrospirae nagZ 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0MK@40117,COG1472@1,COG1472@2 NA|NA|NA G Glycosyl hydrolase family 3 N terminal domain MAG.T1.5_00045 330214.NIDE0245 1.5e-267 928.3 Nitrospirae pepA GO:0001073,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006351,GO:0006355,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009056,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016787,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019538,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042150,GO:0043170,GO:0043171,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043244,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0097718,GO:0140096,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1903506,GO:2000112,GO:2001141 3.4.11.1,3.4.11.5 ko:K01255,ko:K01259 ko00330,ko00480,ko01100,map00330,map00480,map01100 R00135,R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 Bacteria 3J0X7@40117,COG0260@1,COG0260@2 NA|NA|NA E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides MAG.T1.5_00046 330214.NIDE0244 1.3e-100 372.5 Nitrospirae queE 1.97.1.4,4.3.99.3 ko:K04068,ko:K10026 ko00790,ko01100,map00790,map01100 R04710,R10002 RC02989 ko00000,ko00001,ko01000,ko03016 iAF987.Gmet_1658 Bacteria 3J0M2@40117,COG0602@1,COG0602@2 NA|NA|NA H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds MAG.T1.5_00047 330214.NIDE0243 3.6e-107 394.4 Bacteria Bacteria COG0560@1,COG0560@2 NA|NA|NA E Phosphoserine phosphatase MAG.T1.5_00049 330214.NIDE0241 1.1e-196 693.0 Bacteria 2.7.13.3 ko:K10942 ko02020,ko05111,map02020,map05111 M00515 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria COG2202@1,COG2202@2,COG3852@1,COG3852@2 NA|NA|NA T phosphorelay sensor kinase activity MAG.T1.5_00050 56780.SYN_00173 3e-28 131.3 Deltaproteobacteria Bacteria 1QUK7@1224,2WW6W@28221,431U0@68525,COG0784@1,COG0784@2 NA|NA|NA T PFAM response regulator receiver MAG.T1.5_00052 330214.NIDE0238 1.1e-267 929.5 Nitrospirae priA ko:K04066 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 3J0MZ@40117,COG1198@1,COG1198@2 NA|NA|NA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA MAG.T1.5_00054 330214.NIDE0237 2.9e-197 694.9 Bacteria ko:K02557 ko02030,ko02040,map02030,map02040 ko00000,ko00001,ko02000,ko02035 1.A.30.1 Bacteria COG1360@1,COG1360@2 NA|NA|NA N Flagellar Motor Protein MAG.T1.5_00056 330214.NIDE0236 1.7e-63 248.4 Bacteria nuoA 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria COG0838@1,COG0838@2 NA|NA|NA C NADH dehydrogenase (ubiquinone) activity MAG.T1.5_00057 330214.NIDE0235 8.2e-96 356.3 Nitrospirae nuoB 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 3J11S@40117,COG0377@1,COG0377@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient MAG.T1.5_00058 330214.NIDE0234 3.8e-87 327.4 Nitrospirae nuoC GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00332,ko:K13378 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 iAF987.Gmet_3353 Bacteria 3J168@40117,COG0852@1,COG0852@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient MAG.T1.5_00059 330214.NIDE0233 1.5e-244 851.7 Nitrospirae nuoD GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00333,ko:K13378 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 3J0FM@40117,COG0649@1,COG0649@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient MAG.T1.5_00060 330214.NIDE0232 0.0 1666.0 Nitrospirae hcnA 1.4.99.5,1.5.3.1 ko:K00302,ko:K10814 ko00260,ko00460,ko01100,ko01110,map00260,map00460,map01100,map01110 R00374,R00610,R05704 RC00060,RC00557,RC02808 ko00000,ko00001,ko01000,ko02042 Bacteria 3J0UR@40117,COG3383@1,COG3383@2 NA|NA|NA C Molydopterin dinucleotide binding domain MAG.T1.5_00061 330214.NIDE0231 2.7e-100 371.3 Nitrospirae nuoI GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3,1.6.99.3 ko:K00338,ko:K02573,ko:K03941 ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016 M00143,M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1,3.D.1.6 Bacteria 3J0N0@40117,COG1143@1,COG1143@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient MAG.T1.5_00062 330214.NIDE0230 7.4e-81 306.6 Bacteria nuoJ 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria COG0839@1,COG0839@2 NA|NA|NA C Belongs to the complex I subunit 6 family MAG.T1.5_00063 330214.NIDE0229 2.1e-40 171.4 Nitrospirae nuoK GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 ko:K00340,ko:K05576 ko00190,ko01100,map00190,map01100 M00144,M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 3J1AK@40117,COG0713@1,COG0713@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient MAG.T1.5_00064 330214.NIDE0228 0.0 1278.1 Nitrospirae 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 3J0AN@40117,COG1009@1,COG1009@2 NA|NA|NA CP NADH-quinone oxidoreductase MAG.T1.5_00065 330214.NIDE0227 1.8e-268 931.4 Nitrospirae nuoM GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 3J0EQ@40117,COG1008@1,COG1008@2 NA|NA|NA C Evidence 2a Function of homologous gene experimentally demonstrated in an other organism MAG.T1.5_00066 330214.NIDE0226 1.9e-292 1011.1 Nitrospirae ndhD 1.6.5.3 ko:K00342,ko:K05575 ko00190,ko01100,map00190,map01100 M00144,M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 iJN678.ndhD2 Bacteria 3J0EQ@40117,COG1008@1,COG1008@2 NA|NA|NA C Evidence 2a Function of homologous gene experimentally demonstrated in an other organism MAG.T1.5_00067 330214.NIDE0225 3.5e-253 880.6 Nitrospirae nuoN GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 ko:K00343,ko:K05573 ko00190,ko01100,map00190,map01100 M00144,M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 iJN678.ndhB Bacteria 3J0FN@40117,COG1007@1,COG1007@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient MAG.T1.5_00068 330214.NIDE0224 4.9e-202 710.7 Nitrospirae Bacteria 3J12S@40117,COG4251@1,COG4251@2,COG5278@1,COG5278@2 NA|NA|NA T CHASE3 domain MAG.T1.5_00069 330214.NIDE0223 3.2e-75 287.7 Nitrospirae Bacteria 3J151@40117,COG0745@1,COG0745@2 NA|NA|NA T cheY-homologous receiver domain MAG.T1.5_00070 330214.NIDE0222 4.7e-267 926.8 Nitrospirae Bacteria 3J10H@40117,COG0745@1,COG0745@2,COG0784@1,COG0784@2,COG4191@1,COG4191@2 NA|NA|NA T Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_00071 330214.NIDE0221 7.6e-129 466.8 Bacteria Bacteria COG3698@1,COG3698@2 NA|NA|NA S Phosphodiester glycosidase MAG.T1.5_00072 330214.NIDE0220 7.6e-60 236.5 Bacteria Bacteria COG0607@1,COG0607@2 NA|NA|NA P Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS MAG.T1.5_00074 330214.NIDE0218 1.3e-81 309.3 Nitrospirae pyrE 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 iJN678.umpS Bacteria 3J0T8@40117,COG0461@1,COG0461@2 NA|NA|NA F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) MAG.T1.5_00075 330214.NIDE0213 5.7e-36 157.5 Bacteria Bacteria 2CH72@1,32ZK4@2 NA|NA|NA S Protein of unknown function (DUF2878) MAG.T1.5_00076 330214.NIDE0212 6.2e-185 653.7 Bacteria cfa 2.1.1.317,2.1.1.79 ko:K00574,ko:K20238 ko00000,ko01000 iJN746.PP_2734 Bacteria COG2230@1,COG2230@2 NA|NA|NA M cyclopropane-fatty-acyl-phospholipid synthase MAG.T1.5_00077 330214.NIDE0211 4.6e-111 407.5 Bacteria 2.1.1.79 ko:K00574,ko:K09701 ko00000,ko01000 Bacteria COG3496@1,COG3496@2 NA|NA|NA S Protein of unknown function (DUF1365) MAG.T1.5_00078 330214.NIDE0210 5.4e-194 683.7 Bacteria ko:K06954 ko00000 Bacteria COG2907@1,COG2907@2 NA|NA|NA S Flavin containing amine oxidoreductase MAG.T1.5_00079 330214.NIDE0209 1.4e-99 369.4 Nitrospirae sdh Bacteria 3J1EK@40117,COG0300@1,COG0300@2 NA|NA|NA C Enoyl-(Acyl carrier protein) reductase MAG.T1.5_00080 330214.NIDE0208 3e-45 188.0 Bacteria 5.3.3.1 ko:K01822,ko:K21972 ko00140,ko00984,ko01100,ko01120,map00140,map00984,map01100,map01120 M00107,M00110 R01837,R02216,R02499,R02840,R03327,R04163,R04678,R04849,R09955 RC00146,RC00762 ko00000,ko00001,ko00002,ko01000,ko03000 Bacteria COG3631@1,COG3631@2 NA|NA|NA S light absorption MAG.T1.5_00081 330214.NIDE0207 7.5e-66 256.9 Bacteria Bacteria 2E01F@1,32VQP@2 NA|NA|NA S Chalcone isomerase-like MAG.T1.5_00082 330214.NIDE0206 1e-71 276.2 Bacteria Bacteria COG2138@1,COG2138@2 NA|NA|NA S sirohydrochlorin cobaltochelatase activity MAG.T1.5_00083 330214.NIDE0204 1.8e-162 578.6 Nitrospirae ybgA Bacteria 3J13F@40117,COG1683@1,COG1683@2,COG3272@1,COG3272@2 NA|NA|NA S Protein of unknown function (DUF1722) MAG.T1.5_00084 330214.NIDE0203 1.3e-239 835.5 Nitrospirae phr 4.1.99.3 ko:K01669 ko00000,ko01000,ko03400 Bacteria 3J0IW@40117,COG0415@1,COG0415@2 NA|NA|NA H Belongs to the DNA photolyase family MAG.T1.5_00088 330214.NIDE0200 5.8e-48 197.2 Bacteria prc 3.4.21.102 ko:K03797 ko00000,ko01000,ko01002 Bacteria COG0793@1,COG0793@2 NA|NA|NA M Belongs to the peptidase S41A family MAG.T1.5_00089 575540.Isop_2983 1.5e-08 66.2 Planctomycetes Bacteria 2A5QN@1,2J3JM@203682,30UFH@2 NA|NA|NA S Domain of unknown function (DUF4149) MAG.T1.5_00090 330214.NIDE0198 1e-133 483.0 Bacteria yfcH ko:K07071 ko00000 Bacteria COG1090@1,COG1090@2 NA|NA|NA S coenzyme binding MAG.T1.5_00092 330214.NIDE0195 2.4e-129 468.4 Nitrospirae Bacteria 3J14J@40117,COG1262@1,COG1262@2 NA|NA|NA S Evidence 4 Homologs of previously reported genes of MAG.T1.5_00094 330214.NIDE0193 8.8e-182 642.9 Nitrospirae 1.14.99.50 ko:K18912 ko00340,map00340 R11013 RC03323,RC03324 ko00000,ko00001,ko01000 Bacteria 3J14J@40117,COG1262@1,COG1262@2 NA|NA|NA S Evidence 4 Homologs of previously reported genes of MAG.T1.5_00095 330214.NIDE0192 6.3e-171 606.7 Nitrospirae 1.14.99.50 ko:K18912 ko00340,map00340 R11013 RC03323,RC03324 ko00000,ko00001,ko01000 Bacteria 3J14J@40117,COG1262@1,COG1262@2 NA|NA|NA S Evidence 4 Homologs of previously reported genes of MAG.T1.5_00097 330214.NIDE0190 6.5e-141 506.9 Bacteria ycgE ko:K21089,ko:K21972,ko:K22491 ko02026,map02026 ko00000,ko00001,ko03000 Bacteria COG0789@1,COG0789@2,COG5012@1,COG5012@2 NA|NA|NA T cobalamin binding MAG.T1.5_00098 330214.NIDE0189 1.7e-40 172.2 Bacteria Bacteria COG3011@1,COG3011@2 NA|NA|NA CH Protein conserved in bacteria MAG.T1.5_00099 426114.THI_2428 1.1e-12 79.7 unclassified Burkholderiales rnhA 3.1.26.4 ko:K03469 ko03030,map03030 ko00000,ko00001,ko01000,ko03032 Bacteria 1KKSW@119065,1RCZ1@1224,2VR4W@28216,COG0328@1,COG0328@2 NA|NA|NA L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids MAG.T1.5_00100 330214.NIDE0187 9e-48 197.2 Bacteria fliL ko:K02415 ko00000,ko02035 Bacteria COG1580@1,COG1580@2 NA|NA|NA N Controls the rotational direction of flagella during chemotaxis MAG.T1.5_00103 330214.NIDE0169 1.8e-70 271.9 Nitrospirae rplI GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02939 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0MQ@40117,COG0359@1,COG0359@2 NA|NA|NA J binds to the 23S rRNA MAG.T1.5_00104 330214.NIDE0168 2.3e-229 801.2 Nitrospirae glyA GO:0001505,GO:0003674,GO:0003824,GO:0004372,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006546,GO:0006563,GO:0006565,GO:0006730,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009070,GO:0009071,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016741,GO:0016742,GO:0017144,GO:0019264,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042133,GO:0042135,GO:0042136,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 iG2583_1286.G2583_3081 Bacteria 3J0CB@40117,COG0112@1,COG0112@2 NA|NA|NA E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism MAG.T1.5_00105 330214.NIDE0167 5.6e-64 250.4 Nitrospirae nrdR GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 ko:K07738 ko00000,ko03000 Bacteria 3J14C@40117,COG1327@1,COG1327@2 NA|NA|NA K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes MAG.T1.5_00106 330214.NIDE0166 3.8e-191 674.1 Bacteria 1.1.1.103,2.7.13.3 ko:K00060,ko:K07777 ko00260,ko02020,map00260,map02020 M00478 R01465 RC00525 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria COG1063@1,COG1063@2,COG4585@1,COG4585@2 NA|NA|NA E alcohol dehydrogenase MAG.T1.5_00107 330214.NIDE0165 6.9e-116 423.3 Nitrospirae degU ko:K02479,ko:K07692 ko02020,ko02024,map02020,map02024 M00478 ko00000,ko00001,ko00002,ko02022 Bacteria 3J18V@40117,COG2197@1,COG2197@2 NA|NA|NA K helix_turn_helix, Lux Regulon MAG.T1.5_00108 330214.NIDE0164 4.5e-158 563.9 Nitrospirae lpxC GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0008654,GO:0008759,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 3.5.1.108,4.2.1.59 ko:K02535,ko:K16363 ko00061,ko00540,ko01100,ko01212,map00061,map00540,map01100,map01212 M00060,M00083 R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965 RC00166,RC00300,RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004,ko01005 iECS88_1305.ECS88_0100 Bacteria 3J0JG@40117,COG0774@1,COG0774@2 NA|NA|NA M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis MAG.T1.5_00110 330214.NIDE0161 3e-121 441.4 Nitrospirae suhB GO:0003674,GO:0003824,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0042578,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0I4@40117,COG0483@1,COG0483@2 NA|NA|NA G Inositol monophosphatase family MAG.T1.5_00112 330214.NIDE0159 4.7e-57 226.9 Bacteria yurZ 2.3.1.12,4.1.1.44 ko:K00627,ko:K01607 ko00010,ko00020,ko00362,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00010,map00020,map00362,map00620,map01100,map01110,map01120,map01130,map01200,map01220 M00307 R00209,R02569,R03470 RC00004,RC00938,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria COG0599@1,COG0599@2 NA|NA|NA S peroxiredoxin activity MAG.T1.5_00113 330214.NIDE0158 0.0 1171.8 Bacteria Bacteria COG1032@1,COG1032@2 NA|NA|NA C radical SAM domain protein MAG.T1.5_00114 330214.NIDE0156 1.2e-55 222.2 Bacteria phhB GO:0003674,GO:0003824,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008124,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019438,GO:0019751,GO:0034311,GO:0034312,GO:0034641,GO:0042558,GO:0042559,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 4.2.1.96 ko:K01724 ko00790,map00790 R04734 RC01208 ko00000,ko00001,ko01000,ko04147 Bacteria COG2154@1,COG2154@2 NA|NA|NA H pterin-4-alpha-carbinolamine dehydratase MAG.T1.5_00115 330214.NIDE0155 8.4e-79 299.7 Bacteria ko:K07182 ko00000 Bacteria COG0517@1,COG0517@2 NA|NA|NA S IMP dehydrogenase activity MAG.T1.5_00116 1198232.CYCME_1120 1.9e-26 125.9 Thiotrichales ugpQ 3.1.4.46 ko:K01126 ko00564,map00564 R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 Bacteria 1MU8H@1224,1RQWX@1236,462GH@72273,COG0584@1,COG0584@2 NA|NA|NA C Glycerophosphoryl diester phosphodiesterase family MAG.T1.5_00117 330214.NIDE0153 5.8e-73 280.4 Bacteria Bacteria COG0668@1,COG0668@2 NA|NA|NA M transmembrane transport MAG.T1.5_00118 330214.NIDE0150 1.8e-76 292.4 Bacteria Bacteria 2ETF9@1,33KZ8@2 NA|NA|NA S Domain of unknown function (DUF4412) MAG.T1.5_00119 330214.NIDE0149 3.8e-106 391.3 Bacteria Bacteria 2ETF9@1,33KZ8@2 NA|NA|NA S Domain of unknown function (DUF4412) MAG.T1.5_00120 330214.NIDE0147 9.6e-128 463.0 Nitrospirae 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 3J111@40117,COG2326@1,COG2326@2 NA|NA|NA S Polyphosphate kinase 2 (PPK2) MAG.T1.5_00121 330214.NIDE0146 1.7e-87 328.6 Bacteria Bacteria COG2110@1,COG2110@2 NA|NA|NA P phosphatase homologous to the C-terminal domain of histone macroH2A1 MAG.T1.5_00122 330214.NIDE0145 3.5e-111 407.9 Nitrospirae otsB GO:0000287,GO:0003674,GO:0003824,GO:0004805,GO:0005488,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0009058,GO:0009266,GO:0009311,GO:0009312,GO:0009409,GO:0009628,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0033554,GO:0034637,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0046351,GO:0046872,GO:0050896,GO:0051716,GO:0070413,GO:0070415,GO:0070417,GO:0071704,GO:1901576 2.4.1.15,2.4.1.347,3.1.3.12 ko:K00697,ko:K01087,ko:K16055 ko00500,ko01100,map00500,map01100 R02737,R02778 RC00005,RC00017,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 GT20 iE2348C_1286.E2348C_2018,iECED1_1282.ECED1_2163,iECIAI39_1322.ECIAI39_1155,iECS88_1305.ECS88_1952,iLF82_1304.LF82_1582,iNRG857_1313.NRG857_09495 Bacteria 3J0UY@40117,COG1877@1,COG1877@2 NA|NA|NA G Removes the phosphate from trehalose 6-phosphate to produce free trehalose MAG.T1.5_00123 330214.NIDE0144 0.0 1429.5 Nitrospirae otsA 2.4.1.15,2.4.1.245,2.4.1.347,2.5.1.135 ko:K00697,ko:K13057,ko:K20436 ko00500,ko00525,ko01100,ko01130,map00500,map00525,map01100,map01130 M00815 R02737,R08946,R10525,R11239,R11250,R11306,R11497 RC00005,RC00049,RC02748,RC03400,RC03401 ko00000,ko00001,ko00002,ko01000,ko01003 GT20,GT4 Bacteria 3J109@40117,COG0380@1,COG0380@2 NA|NA|NA M Glycosyltransferase family 20 MAG.T1.5_00124 330214.NIDE0143 0.0 1197.2 Bacteria 3.2.1.3 ko:K01178 ko00500,ko01100,map00500,map01100 R01790,R01791,R06199 ko00000,ko00001,ko01000 GH15 Bacteria COG3387@1,COG3387@2 NA|NA|NA G glucan 1,4-alpha-glucosidase activity MAG.T1.5_00126 330214.NIDE0140 4.3e-95 354.0 Bacteria MA20_21045 Bacteria COG5514@1,COG5514@2 NA|NA|NA MAG.T1.5_00127 946483.Cenrod_2703 7.5e-264 916.0 Comamonadaceae 2.1.1.72 ko:K03427 ko00000,ko01000,ko02048 Bacteria 1MW3A@1224,2VIP4@28216,4ABKU@80864,COG0286@1,COG0286@2 NA|NA|NA V N-6 DNA Methylase MAG.T1.5_00128 1286631.X805_28020 3.9e-143 515.0 Betaproteobacteria Bacteria 1R4MD@1224,2WFIY@28216,COG2865@1,COG2865@2 NA|NA|NA K Putative ATP-dependent DNA helicase recG C-terminal MAG.T1.5_00129 292564.Cyagr_1940 3.5e-86 325.9 Cyanobacteria 3.1.21.3 ko:K01154 ko00000,ko01000,ko02048 Bacteria 1G322@1117,COG0732@1,COG0732@2 NA|NA|NA L Type I restriction modification DNA specificity domain MAG.T1.5_00130 946483.Cenrod_2707 0.0 1562.7 Comamonadaceae hsdR_1 3.1.21.3 ko:K01153 ko00000,ko01000,ko02048 Bacteria 1QTS7@1224,2VPCW@28216,4AEDZ@80864,COG4096@1,COG4096@2 NA|NA|NA V Type I site-specific restriction-modification system, R (Restriction) subunit and related MAG.T1.5_00131 743299.Acife_0839 4.7e-239 833.6 Proteobacteria 3.6.4.12 ko:K03655 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 1MXG1@1224,COG2865@1,COG2865@2 NA|NA|NA K Transcriptional regulator MAG.T1.5_00132 330214.NIDE0134 1.6e-39 168.7 Bacteria GO:0002790,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0030255,GO:0032940,GO:0032991,GO:0033036,GO:0042886,GO:0043684,GO:0044097,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0097159,GO:1901363 ko:K19092 ko00000,ko02048 Bacteria COG3668@1,COG3668@2 NA|NA|NA D Plasmid stabilization system MAG.T1.5_00133 1122951.ATUE01000005_gene2074 3e-18 97.4 Gammaproteobacteria Bacteria 1N8QY@1224,1SFWC@1236,COG2161@1,COG2161@2 NA|NA|NA D Antitoxin component of a toxin-antitoxin (TA) module MAG.T1.5_00134 330214.NIDE2805 2.7e-162 578.6 Nitrospirae stp_1 Bacteria 3J18B@40117,COG0477@1,COG2814@2 NA|NA|NA P Major Facilitator Superfamily MAG.T1.5_00135 330214.NIDE2804 3.3e-83 314.7 Bacteria tpm 2.1.1.67 ko:K00569 ko00983,map00983 R08236,R08239,R08246 RC00003,RC00980,RC02277 ko00000,ko00001,ko01000 Bacteria COG0500@1,COG0500@2 NA|NA|NA Q methyltransferase activity MAG.T1.5_00136 330214.NIDE2803 4.2e-127 461.1 Bacteria nodD2 Bacteria COG0583@1,COG0583@2 NA|NA|NA K DNA-binding transcription factor activity MAG.T1.5_00137 626887.J057_10026 2.1e-66 259.6 Alteromonadaceae 3.2.1.35 ko:K01197 ko00531,ko01100,map00531,map01100 M00076,M00077 R07824,R07825,R10905 ko00000,ko00001,ko00002,ko00536,ko00537,ko01000,ko02042 Bacteria 1QR2G@1224,1RZNM@1236,466IG@72275,COG3525@1,COG3525@2 NA|NA|NA G beta-N-acetylglucosaminidase MAG.T1.5_00139 1005048.CFU_0763 1.1e-43 184.1 Oxalobacteraceae Bacteria 1R0XC@1224,2WHXS@28216,475EE@75682,COG0640@1,COG0640@2 NA|NA|NA K STAS-like domain of unknown function (DUF4325) MAG.T1.5_00140 330214.NIDE0059 1e-152 546.2 Nitrospirae dedA_2 Bacteria 3J1E4@40117,COG0586@1,COG0586@2,COG0607@1,COG0607@2 NA|NA|NA P Evidence 4 Homologs of previously reported genes of MAG.T1.5_00141 330214.NIDE0058 1.9e-268 931.4 Bacteria ko:K08218 ko01501,map01501 M00628 ko00000,ko00001,ko00002,ko02000 2.A.1.25 Bacteria COG2211@1,COG2211@2 NA|NA|NA G Major facilitator Superfamily MAG.T1.5_00142 330214.NIDE0057 1.5e-168 599.0 Nitrospirae mauG GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.11.1.5 ko:K00428 ko00000,ko01000 Bacteria 3J0GH@40117,COG1858@1,COG1858@2 NA|NA|NA C Di-haem cytochrome c peroxidase MAG.T1.5_00144 330214.NIDE0055 2.8e-136 491.5 Bacteria oxyR ko:K04761 ko02026,map02026 ko00000,ko00001,ko03000 Bacteria COG0583@1,COG0583@2 NA|NA|NA K DNA-binding transcription factor activity MAG.T1.5_00145 375286.mma_1688 2.5e-12 79.3 Oxalobacteraceae ko:K06867 ko00000 Bacteria 1N952@1224,2VQ59@28216,474AS@75682,COG0666@1,COG0666@2 NA|NA|NA S Ankyrin repeats (many copies) MAG.T1.5_00146 330214.NIDE0052 2.5e-121 441.8 Bacteria rnfB ko:K03616 ko00000 Bacteria COG0491@1,COG0491@2,COG1141@1,COG1141@2 NA|NA|NA C electron transfer activity MAG.T1.5_00147 330214.NIDE0051 1.2e-88 332.8 Bacteria alkA 2.1.1.63,3.2.2.21 ko:K00567,ko:K01247 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria COG0122@1,COG0122@2 NA|NA|NA L 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase MAG.T1.5_00148 330214.NIDE0050 2.2e-58 231.5 Bacteria Bacteria COG0251@1,COG0251@2 NA|NA|NA J oxidation-reduction process MAG.T1.5_00149 330214.NIDE0049 4.8e-86 324.3 Nitrospirae Bacteria 3J0J6@40117,COG1028@1,COG1028@2 NA|NA|NA IQ Evidence 2a Function of homologous gene experimentally demonstrated in an other organism MAG.T1.5_00150 330214.NIDE0048 1.5e-97 362.5 Nitrospirae Bacteria 3J13G@40117,COG0500@1,COG2226@2 NA|NA|NA Q methyltransferase MAG.T1.5_00151 330214.NIDE0047 3e-94 351.3 Bacteria tdsD Bacteria COG0778@1,COG0778@2 NA|NA|NA C coenzyme F420-1:gamma-L-glutamate ligase activity MAG.T1.5_00152 330214.NIDE0044 1.3e-62 245.7 Bacteria osmC GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006970,GO:0006972,GO:0006979,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0033194,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1990748 ko:K04063 ko00000 Bacteria COG1764@1,COG1764@2 NA|NA|NA O response to oxidative stress MAG.T1.5_00153 330214.NIDE0043 0.0 1175.2 Bacteria Bacteria COG1554@1,COG1554@2 NA|NA|NA G hydrolase, family 65, central catalytic MAG.T1.5_00154 330214.NIDE0042 3.5e-119 434.5 Bacteria pgmB GO:0000287,GO:0003674,GO:0003824,GO:0004805,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008801,GO:0009058,GO:0009292,GO:0009294,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016853,GO:0016866,GO:0016868,GO:0019203,GO:0030312,GO:0033554,GO:0034637,GO:0040007,GO:0042221,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0046351,GO:0046677,GO:0046872,GO:0050896,GO:0051704,GO:0051716,GO:0071704,GO:0071944,GO:1901576 2.4.1.64,3.1.3.12,3.2.1.28,5.4.2.6 ko:K01087,ko:K01194,ko:K01838,ko:K05342 ko00500,ko01100,map00500,map01100 R00010,R02727,R02728,R02778,R11310 RC00017,RC00049,RC00408 ko00000,ko00001,ko00537,ko01000 GH37,GH65 Bacteria COG0637@1,COG0637@2 NA|NA|NA S phosphonoacetaldehyde hydrolase activity MAG.T1.5_00156 330214.NIDE0040 5.8e-63 246.9 Bacteria Bacteria COG3678@1,COG3678@2 NA|NA|NA NPTU ATP-independent chaperone mediated protein folding MAG.T1.5_00157 330214.NIDE0039 7.7e-43 179.5 Bacteria Bacteria COG2329@1,COG2329@2 NA|NA|NA S heme oxygenase (decyclizing) activity MAG.T1.5_00160 330214.NIDE0036 7.4e-78 296.6 Nitrospirae ko:K15977 ko00000 Bacteria 3J13I@40117,COG2259@1,COG2259@2 NA|NA|NA S Evidence 4 Homologs of previously reported genes of MAG.T1.5_00161 330214.NIDE0034 1.9e-190 671.8 Nitrospirae ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 3J115@40117,COG0842@1,COG0842@2 NA|NA|NA V ABC-2 family transporter protein MAG.T1.5_00162 330214.NIDE0033 8.2e-186 656.4 Nitrospirae ko:K01992,ko:K13926 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 3J0MP@40117,COG0842@1,COG0842@2 NA|NA|NA V ABC-2 family transporter protein MAG.T1.5_00163 330214.NIDE0032 1.6e-309 1068.1 Bacteria ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria COG1131@1,COG1131@2 NA|NA|NA V ATPase activity MAG.T1.5_00164 330214.NIDE0031 1.6e-162 578.9 Nitrospirae yhiI ko:K01993,ko:K02005 ko00000 Bacteria 3J0TB@40117,COG1566@1,COG1566@2 NA|NA|NA V HlyD family secretion protein MAG.T1.5_00165 330214.NIDE0030 5.3e-72 276.9 Bacteria Bacteria COG3678@1,COG3678@2 NA|NA|NA NPTU ATP-independent chaperone mediated protein folding MAG.T1.5_00166 330214.NIDE0029 0.0 1296.6 Bacteria fhlA GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001150,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016043,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0022607,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035326,GO:0042802,GO:0043170,GO:0043254,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2000144,GO:2001141 ko:K02584,ko:K12146,ko:K12266,ko:K15836,ko:K21009 ko02020,ko02025,ko05132,map02020,map02025,map05132 ko00000,ko00001,ko03000 Bacteria COG2203@1,COG2203@2,COG3604@1,COG3604@2 NA|NA|NA KT transcription factor binding MAG.T1.5_00167 330214.NIDE0028 1.4e-51 208.8 Bacteria Bacteria COG1669@1,COG1669@2 NA|NA|NA S nucleotidyltransferase activity MAG.T1.5_00170 1169143.KB911037_gene4227 6.3e-167 595.1 Burkholderiaceae ko:K03556 ko00000,ko03000 Bacteria 1K5E1@119060,1MVZZ@1224,2VXDK@28216,COG2909@1,COG2909@2,COG3629@1,COG3629@2 NA|NA|NA K Bacterial transcriptional activator domain MAG.T1.5_00171 330214.NIDE0018 4.9e-131 473.8 Nitrospirae Bacteria 3J196@40117,COG1018@1,COG1018@2 NA|NA|NA C Oxidoreductase NAD-binding domain MAG.T1.5_00172 330214.NIDE0017 2.1e-27 127.9 Nitrospirae Bacteria 3J1A6@40117,COG3369@1,COG3369@2 NA|NA|NA S Iron-binding zinc finger CDGSH type MAG.T1.5_00173 330214.NIDE0016 8.2e-73 279.6 Bacteria 1.13.11.2 ko:K07104 ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220 M00569 R00816,R04089,R05295,R05404,R05406,R07795 RC00387,RC00643,RC01075,RC01364,RC01914 ko00000,ko00001,ko00002,ko01000 Bacteria COG2514@1,COG2514@2 NA|NA|NA S catechol 2,3-dioxygenase activity MAG.T1.5_00174 330214.NIDE0015 8.6e-58 229.6 Bacteria Bacteria 2CIIF@1,315FB@2 NA|NA|NA MAG.T1.5_00175 330214.NIDE0014 1.6e-186 658.7 Bacteria 1.2.3.3,1.6.5.2,1.7.1.15 ko:K00158,ko:K00363,ko:K03809,ko:K05710 ko00130,ko00360,ko00620,ko00910,ko01100,ko01110,ko01120,ko01220,map00130,map00360,map00620,map00910,map01100,map01110,map01120,map01220 M00530,M00545 R00207,R00787,R02964,R03643,R03816,R06782,R06783 RC00098,RC00176,RC00819,RC02745 br01602,ko00000,ko00001,ko00002,ko01000 Bacteria COG0655@1,COG0655@2,COG2146@1,COG2146@2 NA|NA|NA S NAD(P)H dehydrogenase (quinone) activity MAG.T1.5_00176 382464.ABSI01000011_gene2994 1.5e-37 162.5 Verrucomicrobiae Bacteria 2DQ7E@1,2IUQR@203494,3353C@2,46SU5@74201 NA|NA|NA S Domain of unknown function (DUF5069) MAG.T1.5_00177 330214.NIDE0012 6.5e-70 270.0 Bacteria fosB2 4.4.1.5 ko:K01759 ko00620,map00620 R02530 RC00004,RC00740 ko00000,ko00001,ko01000 Bacteria COG0346@1,COG0346@2 NA|NA|NA E lactoylglutathione lyase activity MAG.T1.5_00178 330214.NIDE0011 4e-89 334.3 Bacteria Bacteria COG2761@1,COG2761@2 NA|NA|NA Q protein disulfide oxidoreductase activity MAG.T1.5_00179 330214.NIDE0010 5.3e-140 503.8 Nitrospirae yhhW_1 ko:K06911 ko00000 Bacteria 3J125@40117,COG1741@1,COG1741@2 NA|NA|NA S Pirin MAG.T1.5_00180 330214.NIDE0009 5.9e-120 437.2 Bacteria Bacteria COG0702@1,COG0702@2 NA|NA|NA GM epimerase MAG.T1.5_00181 330214.NIDE0007 2.4e-78 298.1 Nitrospirae smpB GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0070930,GO:0071704,GO:0097159,GO:1901363,GO:1901564 ko:K03664 ko00000 Bacteria 3J0Q4@40117,COG0691@1,COG0691@2 NA|NA|NA O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA MAG.T1.5_00182 330214.NIDE0006 1.6e-56 225.7 Bacteria Bacteria COG5512@1,COG5512@2 NA|NA|NA L Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives MAG.T1.5_00184 330214.NIDE0004 0.0 1546.2 Nitrospirae gyrA 5.99.1.3 ko:K02469 ko00000,ko01000,ko03032,ko03400 Bacteria 3J0EH@40117,COG0188@1,COG0188@2 NA|NA|NA L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner MAG.T1.5_00185 330214.NIDE0003 0.0 1544.6 Nitrospirae gyrB GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 ko:K02470 ko00000,ko01000,ko03032,ko03400 Bacteria 3J0BB@40117,COG0187@1,COG0187@2 NA|NA|NA L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner MAG.T1.5_00186 330214.NIDE0002 1.6e-197 695.3 Nitrospirae dnaN 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 3J0RU@40117,COG0592@1,COG0592@2 NA|NA|NA L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria MAG.T1.5_00187 330214.NIDE0001 3.4e-239 833.9 Nitrospirae dnaA GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010556,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:1990837,GO:2000112 ko:K02313 ko02020,ko04112,map02020,map04112 ko00000,ko00001,ko03032,ko03036 Bacteria 3J0FQ@40117,COG0593@1,COG0593@2 NA|NA|NA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids MAG.T1.5_00190 330214.NIDE4398 2.1e-46 191.4 Nitrospirae ko:K06039,ko:K07235 ko04122,map04122 ko00000,ko00001,ko01000,ko03016 Bacteria 3J1AA@40117,COG1553@1,COG1553@2 NA|NA|NA P Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE MAG.T1.5_00191 330214.NIDE4397 1.9e-215 755.0 Nitrospirae hisS GO:0003674,GO:0003824,GO:0004812,GO:0004821,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006427,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iE2348C_1286.E2348C_2797,iECNA114_1301.ECNA114_2592,iECSF_1327.ECSF_2358 Bacteria 3J0EC@40117,COG0124@1,COG0124@2 NA|NA|NA J Histidyl-tRNA synthetase MAG.T1.5_00193 330214.NIDE4396 1e-260 905.6 Bacteria thyX 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 R06613 RC00022,RC00332 ko00000,ko00001,ko01000 Bacteria COG1351@1,COG1351@2 NA|NA|NA F thymidylate synthase (FAD) activity MAG.T1.5_00194 330214.NIDE4395 1.6e-55 223.4 Nitrospirae Bacteria 3J1CG@40117,COG0457@1,COG0457@2 NA|NA|NA S Evidence 5 No homology to any previously reported sequences MAG.T1.5_00198 330214.NIDE4390 2.9e-54 217.6 Nitrospirae ko:K04752 ko00000 Bacteria 3J17N@40117,COG0347@1,COG0347@2 NA|NA|NA K Evidence 2b Function of strongly homologous gene MAG.T1.5_00199 330214.NIDE4388 0.0 1915.2 Nitrospirae ko:K09822 ko00000 Bacteria 3J0VY@40117,COG3002@1,COG3002@2 NA|NA|NA S Uncharacterized protein conserved in bacteria (DUF2309) MAG.T1.5_00200 330214.NIDE4387 5.4e-165 587.4 Bacteria nuoM GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria COG1008@1,COG1008@2 NA|NA|NA C NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient MAG.T1.5_00201 330214.NIDE4386 1.7e-288 998.0 Nitrospirae nuoL2 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 3J0AN@40117,COG1009@1,COG1009@2 NA|NA|NA CP NADH-quinone oxidoreductase MAG.T1.5_00202 330214.NIDE4385 4.9e-55 220.3 Nitrospirae yrhF Bacteria 3J180@40117,COG5609@1,COG5609@2 NA|NA|NA S Uncharacterized conserved protein (DUF2294) MAG.T1.5_00203 330214.NIDE4384 5.4e-262 909.8 Bacteria ydiU ko:K08997 ko00000 Bacteria COG0397@1,COG0397@2 NA|NA|NA S Uncharacterized ACR, YdiU/UPF0061 family MAG.T1.5_00204 330214.NIDE4383 6.6e-297 1026.9 Bacteria Bacteria COG0683@1,COG0683@2 NA|NA|NA E ABC-type branched-chain amino acid transport systems, periplasmic component MAG.T1.5_00205 330214.NIDE4382 4.8e-123 447.2 Nitrospirae sll1284 ko:K06999 ko00000 Bacteria 3J1DU@40117,COG0400@1,COG0400@2 NA|NA|NA S Alpha/beta hydrolase family MAG.T1.5_00206 330214.NIDE4381 3.6e-129 467.6 Bacteria MA20_24420 ko:K06889,ko:K07000 ko00000 Bacteria COG1073@1,COG1073@2 NA|NA|NA S thiolester hydrolase activity MAG.T1.5_00210 330214.NIDE4379 4.1e-131 474.2 Bacteria MA20_19930 ko:K07226 ko00000 Bacteria COG0748@1,COG0748@2 NA|NA|NA P coenzyme F420 binding MAG.T1.5_00211 330214.NIDE4378 9.4e-111 406.4 Bacteria Bacteria COG2930@1,COG2930@2 NA|NA|NA S regulation of ruffle assembly MAG.T1.5_00212 330214.NIDE4377 0.0 1079.3 Nitrospirae yjjK GO:0003674,GO:0003824,GO:0005488,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:2000112,GO:2000113 3.6.3.25 ko:K06020 ko00000,ko01000 Bacteria 3J0WR@40117,COG0488@1,COG0488@2 NA|NA|NA S ABC transporter MAG.T1.5_00213 330214.NIDE4376 1.5e-159 569.3 Bacteria ko:K07001 ko00000 Bacteria COG1752@1,COG1752@2 NA|NA|NA M Esterase of the alpha-beta hydrolase superfamily MAG.T1.5_00214 330214.NIDE4375 8e-88 330.1 Bacteria 1.1.1.271 ko:K02377 ko00051,ko00520,ko01100,map00051,map00520,map01100 R05692 RC01014 ko00000,ko00001,ko01000 Bacteria COG0702@1,COG0702@2 NA|NA|NA GM epimerase MAG.T1.5_00215 330214.NIDE4374 1.5e-121 442.6 Bacteria rmlD 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 Bacteria COG1091@1,COG1091@2 NA|NA|NA M dTDP-4-dehydrorhamnose reductase activity MAG.T1.5_00216 330214.NIDE4373 1e-36 159.5 Bacteria ko:K12263 ko00000 Bacteria COG2010@1,COG2010@2 NA|NA|NA C Cytochrome c MAG.T1.5_00217 330214.NIDE4372 1.1e-115 422.9 Bacteria Bacteria COG3752@1,COG3752@2 NA|NA|NA M Protein of unknown function (DUF1295) MAG.T1.5_00218 330214.NIDE4370 1.3e-18 98.6 Bacteria Bacteria 2EQIW@1,33I4X@2 NA|NA|NA MAG.T1.5_00219 330214.NIDE4369 7.7e-37 159.5 Bacteria ko:K07743 ko00000 Bacteria COG3357@1,COG3357@2 NA|NA|NA K Transcriptional regulator containing an HTH domain fused to a Zn-ribbon MAG.T1.5_00220 330214.NIDE4368 1.8e-262 911.4 Bacteria tldD2 ko:K03568 ko00000,ko01002 Bacteria COG0312@1,COG0312@2 NA|NA|NA S metallopeptidase activity MAG.T1.5_00221 330214.NIDE4367 1.9e-229 801.6 Bacteria tldE2 Bacteria COG0312@1,COG0312@2 NA|NA|NA S metallopeptidase activity MAG.T1.5_00223 448385.sce2596 2.8e-142 512.3 Myxococcales Bacteria 1N0A9@1224,2WTRV@28221,2YUFX@29,42YQ0@68525,COG0457@1,COG0457@2 NA|NA|NA S COG0457 FOG TPR repeat MAG.T1.5_00224 330214.NIDE4363 2.1e-130 471.9 Bacteria Bacteria COG0500@1,COG2226@2 NA|NA|NA Q methyltransferase MAG.T1.5_00225 330214.NIDE4362 2.5e-84 318.2 Nitrospirae 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 Bacteria 3J0TX@40117,COG1611@1,COG1611@2 NA|NA|NA S Belongs to the LOG family MAG.T1.5_00226 330214.NIDE4361 3e-65 254.6 Bacteria Bacteria COG5608@1,COG5608@2 NA|NA|NA S Late embryogenesis abundant protein MAG.T1.5_00227 330214.NIDE4360 3.3e-88 331.3 Bacteria msrA 1.8.4.11,1.8.4.12 ko:K07304,ko:K12267 ko00000,ko01000 Bacteria COG0225@1,COG0225@2 NA|NA|NA O peptide-methionine (S)-S-oxide reductase activity MAG.T1.5_00228 330214.NIDE4359 3.4e-52 211.1 Nitrospirae yccU GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 ko:K06929 ko00000 Bacteria 3J19F@40117,COG1832@1,COG1832@2 NA|NA|NA S CoA binding domain MAG.T1.5_00230 330214.NIDE4356 2.5e-67 261.9 Bacteria Bacteria COG0741@1,COG0741@2 NA|NA|NA M lytic transglycosylase activity MAG.T1.5_00231 330214.NIDE4355 6.6e-199 699.9 Nitrospirae ko:K10907 ko00000,ko01000,ko01007 Bacteria 3J0EV@40117,COG0436@1,COG0436@2 NA|NA|NA E Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_00232 272134.KB731324_gene3811 2e-54 219.5 Oscillatoriales 2.7.13.3,3.1.3.3 ko:K07315,ko:K11527 ko00000,ko01000,ko01001,ko02022,ko03021 Bacteria 1G3XH@1117,1H73M@1150,COG2203@1,COG2203@2,COG3437@1,COG3437@2,COG5000@1,COG5000@2,COG5002@1,COG5002@2 NA|NA|NA T Belongs to the adenylyl cyclase class-4 guanylyl cyclase family MAG.T1.5_00234 330214.NIDE4352 7.4e-110 403.7 Bacteria mmsB 1.1.1.31,1.1.1.60 ko:K00020,ko:K00042 ko00280,ko00630,ko01100,map00280,map00630,map01100 R01745,R01747,R05066 RC00099 ko00000,ko00001,ko01000 Bacteria COG2084@1,COG2084@2 NA|NA|NA I phosphogluconate dehydrogenase (decarboxylating) activity MAG.T1.5_00235 330214.NIDE4351 1.6e-106 392.5 Bacteria suhB2 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 Bacteria COG0483@1,COG0483@2 NA|NA|NA G inositol monophosphate 1-phosphatase activity MAG.T1.5_00236 330214.NIDE4350 5.2e-190 670.2 Bacteria corA GO:0000041,GO:0000287,GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015087,GO:0015095,GO:0015318,GO:0015693,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0046914,GO:0046915,GO:0050897,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0070838,GO:0071840,GO:0071944,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:1903830 ko:K03284 ko00000,ko02000 1.A.35.1,1.A.35.3 Bacteria COG0598@1,COG0598@2 NA|NA|NA P Magnesium transport protein CorA MAG.T1.5_00237 1000565.METUNv1_03477 1.6e-27 129.0 Rhodocyclales Bacteria 1MZ7P@1224,2DM6D@1,2KYYM@206389,2VUHB@28216,31WQ8@2 NA|NA|NA MAG.T1.5_00238 330214.NIDE4348 1.9e-107 395.2 Nitrospirae leuD GO:0003674,GO:0003824,GO:0003861,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009316,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 4.2.1.33,4.2.1.35,4.2.1.36 ko:K01704,ko:K01705 ko00290,ko00300,ko00660,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00300,map00660,map01100,map01110,map01120,map01130,map01210,map01230 M00030,M00432,M00433,M00535 R03896,R03898,R03968,R04001,R04371,R10170 RC00618,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 3J10U@40117,COG0066@1,COG0066@2 NA|NA|NA E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate MAG.T1.5_00239 330214.NIDE4347 8.4e-265 919.1 Nitrospirae leuC 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 3J0IH@40117,COG0065@1,COG0065@2 NA|NA|NA H Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate MAG.T1.5_00242 330214.NIDE4343 2.5e-65 255.0 Bacteria Bacteria 2C3ZQ@1,32SCF@2 NA|NA|NA S MEKHLA domain MAG.T1.5_00243 330214.NIDE4342 5.7e-27 126.3 Bacteria ko:K09705 ko00000 Bacteria COG4728@1,COG4728@2 NA|NA|NA FJ Protein conserved in bacteria MAG.T1.5_00244 330214.NIDE4341 6.8e-222 776.5 Nitrospirae pdhD 1.16.1.1,1.8.1.4 ko:K00382,ko:K00520 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 3J11P@40117,COG1249@1,COG1249@2 NA|NA|NA C Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain MAG.T1.5_00248 330214.NIDE4337 4.6e-138 497.3 Bacteria Bacteria COG0668@1,COG0668@2 NA|NA|NA M transmembrane transport MAG.T1.5_00250 330214.NIDE4335 3.1e-144 517.7 Nitrospirae xthA GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008853,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.11.2 ko:K01142 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 3J13K@40117,COG0708@1,COG0708@2 NA|NA|NA L Endonuclease/Exonuclease/phosphatase family MAG.T1.5_00255 330214.NIDE4332 2.5e-93 348.2 Bacteria lemA ko:K03744 ko00000 Bacteria COG1704@1,COG1704@2 NA|NA|NA S LemA family MAG.T1.5_00256 330214.NIDE4331 3.7e-96 358.2 Bacteria ko:K06872 ko00000 Bacteria COG1512@1,COG1512@2 NA|NA|NA S TPM domain MAG.T1.5_00257 330214.NIDE4330 9e-84 316.6 Bacteria ko:K08988 ko00000 Bacteria COG3762@1,COG3762@2 NA|NA|NA S Membrane MAG.T1.5_00258 330214.NIDE4329 4.4e-265 920.2 Nitrospirae murJ ko:K03980 ko00000,ko01011,ko02000 2.A.66.4 Bacteria 3J0CQ@40117,COG0728@1,COG0728@2 NA|NA|NA S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane MAG.T1.5_00259 330214.NIDE4328 2e-59 235.3 Nitrospirae ogt 2.1.1.63 ko:K00567,ko:K10778,ko:K13531 ko00000,ko01000,ko03000,ko03400 Bacteria 3J1A8@40117,COG0350@1,COG0350@2 NA|NA|NA L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated MAG.T1.5_00260 330214.NIDE4327 1.2e-60 239.2 Nitrospirae dtd GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106026,GO:0106074,GO:0140098,GO:0140101,GO:1901360 ko:K07560 ko00000,ko01000,ko03016 Bacteria 3J149@40117,COG1490@1,COG1490@2 NA|NA|NA J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality MAG.T1.5_00261 330214.NIDE4326 3.2e-98 364.4 Bacteria Bacteria 2CK1C@1,32SJA@2 NA|NA|NA MAG.T1.5_00262 330214.NIDE4324 5.5e-132 477.2 Nitrospirae aspG GO:0005575,GO:0005623,GO:0042597,GO:0044464 3.4.19.5,3.5.1.1,3.5.1.26 ko:K01424,ko:K01444,ko:K13051 ko00250,ko00460,ko00511,ko01100,ko01110,ko04142,map00250,map00460,map00511,map01100,map01110,map04142 R00485 RC00010,RC02798 ko00000,ko00001,ko01000,ko01002 Bacteria 3J19S@40117,COG1446@1,COG1446@2 NA|NA|NA E Asparaginase MAG.T1.5_00263 330214.NIDE4323 7.2e-58 229.9 Bacteria ko:K06991 ko00000 Bacteria COG3565@1,COG3565@2 NA|NA|NA S Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily MAG.T1.5_00264 330214.NIDE4322 8.3e-121 439.9 Nitrospirae mtgA GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008955,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0030203,GO:0034645,GO:0042546,GO:0043164,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.4.1.129,3.4.16.4 ko:K03814,ko:K05365 ko00550,map00550 R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 GT51 Bacteria 3J127@40117,COG0744@1,COG0744@2 NA|NA|NA M Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors MAG.T1.5_00265 330214.NIDE4321 3.3e-101 374.4 Nitrospirae engB GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:0097367,GO:1901265,GO:1901363 ko:K03978 ko00000,ko03036 Bacteria 3J1D5@40117,COG0218@1,COG0218@2 NA|NA|NA D Necessary for normal cell division and for the maintenance of normal septation MAG.T1.5_00266 330214.NIDE4320 1.1e-141 509.6 Nitrospirae surA 5.2.1.8 ko:K02597,ko:K03769,ko:K03771 ko00000,ko01000,ko03110 Bacteria 3J0SR@40117,COG0760@1,COG0760@2 NA|NA|NA O SurA N-terminal domain MAG.T1.5_00267 330214.NIDE4319 9.2e-140 503.1 Nitrospirae prsA 3.1.3.16,5.2.1.8 ko:K01802,ko:K03769,ko:K07533,ko:K20074 ko00000,ko01000,ko01009,ko03110 Bacteria 3J16U@40117,COG0760@1,COG0760@2 NA|NA|NA O PPIC-type PPIASE domain MAG.T1.5_00268 330214.NIDE4318 0.0 2155.9 Nitrospirae mfd GO:0000715,GO:0000716,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006289,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031326,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051276,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1903506,GO:2000112,GO:2001141 ko:K03723 ko03420,map03420 ko00000,ko00001,ko01000,ko03400 Bacteria 3J0BA@40117,COG1197@1,COG1197@2 NA|NA|NA L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site MAG.T1.5_00269 330214.NIDE4317 4.4e-72 277.3 Nitrospirae aut 2.7.1.167,2.7.7.70 ko:K03272,ko:K21345 ko00540,ko01100,map00540,map01100 M00064 R05644,R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 Bacteria 3J0JP@40117,COG0615@1,COG0615@2 NA|NA|NA H Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose MAG.T1.5_00270 330214.NIDE4316 2.8e-184 651.4 Bacteria dinB GO:0003674,GO:0003824,GO:0003887,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 ko:K02346 ko00000,ko01000,ko03400 Bacteria COG0389@1,COG0389@2 NA|NA|NA L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII MAG.T1.5_00271 330214.NIDE4315 1e-76 293.1 Bacteria sprT ko:K02742 ko00000 Bacteria COG3091@1,COG3091@2 NA|NA|NA K SprT-like family MAG.T1.5_00272 330214.NIDE4314 2.2e-166 591.7 Bacteria Bacteria COG1899@1,COG1899@2 NA|NA|NA O peptidyl-lysine modification to peptidyl-hypusine MAG.T1.5_00273 330214.NIDE4313 5.4e-93 347.1 Nitrospirae gmhA 5.3.1.28 ko:K03271 ko00540,ko01100,map00540,map01100 M00064 R05645,R09768,R09769 RC00434 ko00000,ko00001,ko00002,ko01000,ko01005 Bacteria 3J0HG@40117,COG0279@1,COG0279@2 NA|NA|NA G Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate MAG.T1.5_00275 330214.NIDE4312 9.6e-140 503.1 Nitrospirae qmcA Bacteria 3J0NF@40117,COG0330@1,COG0330@2 NA|NA|NA O prohibitin homologues MAG.T1.5_00276 330214.NIDE4311 8.9e-64 249.6 Bacteria ko:K07340 ko00000 Bacteria COG1585@1,COG1585@2 NA|NA|NA OU cellular response to DNA damage stimulus MAG.T1.5_00277 1125863.JAFN01000001_gene3192 6.4e-30 138.7 Deltaproteobacteria Bacteria 1R4YZ@1224,2WNS2@28221,42S9R@68525,COG0457@1,COG0457@2 NA|NA|NA S CRISPR-associated protein (Cas_Cas02710) MAG.T1.5_00278 497964.CfE428DRAFT_2242 8.1e-15 86.7 Verrucomicrobia 2.6.1.102 ko:K13010 ko00520,map00520 R10460 RC00006,RC00781 ko00000,ko00001,ko01000,ko01005,ko01007 Bacteria 46T3Z@74201,COG0399@1,COG0399@2 NA|NA|NA M 23S rRNA-intervening sequence protein MAG.T1.5_00279 330214.NIDE4308 8.8e-58 229.6 Nitrospirae ysmA ko:K07107 ko00000,ko01000 Bacteria 3J1EV@40117,COG0824@1,COG0824@2 NA|NA|NA S Thioesterase-like superfamily MAG.T1.5_00281 530564.Psta_3098 2.3e-38 167.2 Planctomycetes Bacteria 2IXJ9@203682,COG0457@1,COG0457@2,COG2755@1,COG2755@2 NA|NA|NA E Tetratricopeptide repeat MAG.T1.5_00282 330214.NIDE4307 1.9e-196 691.8 Bacteria Z012_00180 3.1.1.5 ko:K10804 ko01040,map01040 ko00000,ko00001,ko01000,ko01004 Bacteria COG2755@1,COG2755@2 NA|NA|NA E lipolytic protein G-D-S-L family MAG.T1.5_00283 330214.NIDE4306 3.6e-89 334.7 Bacteria Bacteria COG2755@1,COG2755@2 NA|NA|NA E lipolytic protein G-D-S-L family MAG.T1.5_00284 330214.NIDE4304 1e-114 419.5 Bacteria 3.5.1.28 ko:K11066,ko:K12287 ko00000,ko01000,ko01011,ko02044 Bacteria COG3023@1,COG3023@2 NA|NA|NA V N-Acetylmuramoyl-L-alanine amidase MAG.T1.5_00285 330214.NIDE4302 4.4e-44 184.1 Bacteria ko:K03668 ko00000 Bacteria COG3187@1,COG3187@2 NA|NA|NA O response to heat MAG.T1.5_00286 330214.NIDE4301 1.1e-66 259.6 Bacteria 1.1.1.25,2.3.1.128,4.2.1.10 ko:K03790,ko:K13832 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413,R03084 RC00206,RC00848 ko00000,ko00001,ko00002,ko01000,ko03009 Bacteria COG1670@1,COG1670@2 NA|NA|NA J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins MAG.T1.5_00287 748247.AZKH_1177 6.1e-39 167.9 Betaproteobacteria Bacteria 1N4MH@1224,2D2IW@1,2W1UY@28216,32TCX@2 NA|NA|NA S Protein of unknown function (DUF1353) MAG.T1.5_00288 589865.DaAHT2_2594 1.1e-117 429.5 Deltaproteobacteria Bacteria 1RKCP@1224,2B22M@1,2WX4F@28221,31UJI@2,4321G@68525 NA|NA|NA L Restriction endonuclease MAG.T1.5_00289 330214.NIDE4295 1.4e-94 352.4 Bacteria Bacteria COG1525@1,COG1525@2 NA|NA|NA L nuclease MAG.T1.5_00291 330214.NIDE4293 3.7e-227 793.9 Nitrospirae hemL GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016853,GO:0016866,GO:0016869,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042286,GO:0042440,GO:0042802,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 iSB619.SA_RS08395,iUMNK88_1353.UMNK88_158 Bacteria 3J0B3@40117,COG0001@1,COG0001@2 NA|NA|NA H Aminotransferase class-III MAG.T1.5_00294 330214.NIDE4290 1.3e-56 225.7 Bacteria yidB Bacteria COG3753@1,COG3753@2 NA|NA|NA S Bacterial protein of unknown function (DUF937) MAG.T1.5_00295 330214.NIDE4289 2.4e-87 328.2 Bacteria Bacteria COG2732@1,COG2732@2 NA|NA|NA K (Barnase) inhibitor MAG.T1.5_00296 330214.NIDE4288 4e-54 217.6 Bacteria GO:0005575,GO:0005576 ko:K03628,ko:K15125 ko03018,ko05133,map03018,map05133 ko00000,ko00001,ko00536,ko03019,ko03021 Bacteria COG4290@1,COG4290@2 NA|NA|NA F endoribonuclease activity MAG.T1.5_00297 330214.NIDE4287 0.0 1389.0 Bacteria pfkA 2.7.1.11,2.7.1.90 ko:K00850,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 Bacteria COG0205@1,COG0205@2,COG0406@1,COG0406@2 NA|NA|NA G 6-phosphofructokinase activity MAG.T1.5_00298 330214.NIDE4286 2.7e-229 801.2 Nitrospirae pyk GO:0003674,GO:0003824,GO:0004743,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 iAF987.Gmet_0122 Bacteria 3J0XM@40117,COG0469@1,COG0469@2 NA|NA|NA G Belongs to the pyruvate kinase family MAG.T1.5_00300 330214.NIDE4284 9.7e-115 419.5 Nitrospirae gph 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 R01334 RC00017 ko00000,ko00001,ko01000 Bacteria 3J0QE@40117,COG0546@1,COG0546@2 NA|NA|NA S HAD-hyrolase-like MAG.T1.5_00301 330214.NIDE4283 7.2e-265 919.5 Nitrospirae pqqL ko:K07263 ko00000,ko01000,ko01002 Bacteria 3J0BY@40117,COG0612@1,COG0612@2 NA|NA|NA S Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_00302 330214.NIDE4282 4.5e-237 827.0 Nitrospirae ymxG ko:K07263 ko00000,ko01000,ko01002 Bacteria 3J0I5@40117,COG0612@1,COG0612@2 NA|NA|NA S Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_00303 330214.NIDE4281 2.1e-125 455.3 Nitrospirae gloB 3.1.2.6 ko:K01069 ko00620,map00620 R01736 RC00004,RC00137 ko00000,ko00001,ko01000 Bacteria 3J17T@40117,COG0491@1,COG0491@2,COG1396@1,COG1396@2 NA|NA|NA K Metallo-beta-lactamase superfamily MAG.T1.5_00304 330214.NIDE4279 2.6e-148 531.6 Nitrospirae Bacteria 3J0KK@40117,COG1994@1,COG1994@2 NA|NA|NA S Peptidase family M50 MAG.T1.5_00305 330214.NIDE4278 1e-96 359.8 Bacteria Bacteria 2DC00@1,2ZC4V@2 NA|NA|NA MAG.T1.5_00306 1322246.BN4_11311 1.1e-13 83.2 Desulfovibrionales Bacteria 1R5HW@1224,2M8MB@213115,2WMXD@28221,42R1Y@68525,COG1361@1,COG1361@2 NA|NA|NA M Protein of unknown function (DUF1566) MAG.T1.5_00307 330214.NIDE4265 7.8e-304 1049.3 Nitrospirae hyfB GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K12137,ko:K15828 ko00000,ko01000 iB21_1397.B21_02538,iECBD_1354.ECBD_1002,iECB_1328.ECB_02573,iECD_1391.ECD_02573,iECED1_1282.ECED1_3174,iECO111_1330.ECO111_3443,iECO26_1355.ECO26_3788,iECP_1309.ECP_2686,iEKO11_1354.EKO11_1252,iEcHS_1320.EcHS_A2859,iLF82_1304.LF82_1065,iNRG857_1313.NRG857_13330 Bacteria 3J0HR@40117,COG0651@1,COG0651@2 NA|NA|NA CP Proton-conducting membrane transporter MAG.T1.5_00308 330214.NIDE4264 2.7e-142 511.5 Nitrospirae hycD Bacteria 3J0RR@40117,COG0650@1,COG0650@2 NA|NA|NA C NADH dehydrogenase MAG.T1.5_00309 330214.NIDE4263 3.2e-97 361.3 Nitrospirae hyfE GO:0008150,GO:0040007 ko:K12140 ko00000,ko01000 Bacteria 3J166@40117,COG4237@1,COG4237@2 NA|NA|NA C Hydrogenase 4 membrane MAG.T1.5_00310 330214.NIDE4262 2.8e-237 827.8 Nitrospirae hyfF GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0033554,GO:0044425,GO:0044464,GO:0050896,GO:0051716,GO:0071944 ko:K12141 ko00000,ko01000 iECIAI39_1322.ECIAI39_2625,iZ_1308.Z3746 Bacteria 3J0PA@40117,COG0651@1,COG0651@2 NA|NA|NA CP Proton-conducting membrane transporter MAG.T1.5_00311 330214.NIDE4261 4.8e-264 916.8 Nitrospirae hycE 1.6.5.3 ko:K00332,ko:K13378 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 3J0W2@40117,COG0852@1,COG0852@2,COG3261@1,COG3261@2 NA|NA|NA C Respiratory-chain NADH dehydrogenase, 30 Kd subunit MAG.T1.5_00312 330214.NIDE4260 1.7e-77 295.4 Nitrospirae Bacteria 3J0NM@40117,COG3260@1,COG3260@2 NA|NA|NA C NADH ubiquinone oxidoreductase, 20 Kd subunit MAG.T1.5_00313 330214.NIDE3948 8.2e-123 447.2 Bacteria Bacteria 2CB8G@1,2Z88H@2 NA|NA|NA S Putative beta-barrel porin-2, OmpL-like. bbp2 MAG.T1.5_00314 330214.NIDE4258 7.4e-108 396.7 Bacteria Bacteria 2E4EY@1,32ZA4@2 NA|NA|NA MAG.T1.5_00315 330214.NIDE4258 9.8e-31 140.6 Bacteria Bacteria 2E4EY@1,32ZA4@2 NA|NA|NA MAG.T1.5_00316 330214.NIDE4257 1.6e-137 495.7 Nitrospirae glxR 1.1.1.31,1.1.1.60 ko:K00020,ko:K00042 ko00280,ko00630,ko01100,map00280,map00630,map01100 R01745,R01747,R05066 RC00099 ko00000,ko00001,ko01000 iJN678.mmsB Bacteria 3J0R5@40117,COG2084@1,COG2084@2 NA|NA|NA I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase MAG.T1.5_00318 330214.NIDE4254 1.2e-244 852.0 Bacteria Bacteria COG0624@1,COG0624@2 NA|NA|NA E succinyl-diaminopimelate desuccinylase activity MAG.T1.5_00319 330214.NIDE4252 8.9e-181 639.4 Bacteria aniA 1.16.3.3,1.7.2.1 ko:K00368,ko:K22349 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 Bacteria COG2132@1,COG2132@2 NA|NA|NA Q Multicopper oxidase MAG.T1.5_00320 330214.NIDE4251 1.4e-171 609.0 Nitrospirae adhC GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.1.1.1 ko:K13953,ko:K13979 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 Bacteria 3J0Y9@40117,COG1064@1,COG1064@2 NA|NA|NA C Zinc-binding dehydrogenase MAG.T1.5_00321 886377.Murru_2564 9.4e-10 70.1 Flavobacteriia MA20_36130 Bacteria 1I2PC@117743,2DMHT@1,32RN3@2,4NPZK@976 NA|NA|NA S PEGA domain MAG.T1.5_00323 330214.NIDE4247 3.5e-45 188.0 Nitrospirae ko:K00406,ko:K12263 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 ko00000,ko00001,ko00002 3.D.4.3 Bacteria 3J1AX@40117,COG2010@1,COG2010@2 NA|NA|NA C Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_00324 330214.NIDE4246 1.2e-40 172.2 Bacteria Bacteria COG5662@1,COG5662@2 NA|NA|NA K AntiSigma factor MAG.T1.5_00325 330214.NIDE4245 8.9e-97 359.8 Nitrospirae ko:K03088 ko00000,ko03021 Bacteria 3J1A1@40117,COG1595@1,COG1595@2 NA|NA|NA K Belongs to the sigma-70 factor family. ECF subfamily MAG.T1.5_00327 330214.NIDE4242 3.5e-239 833.9 Nitrospirae der ko:K03977 ko00000,ko03009 Bacteria 3J0G3@40117,COG1160@1,COG1160@2 NA|NA|NA S GTPase that plays an essential role in the late steps of ribosome biogenesis MAG.T1.5_00328 330214.NIDE4241 2.3e-106 391.7 Bacteria 3.1.3.5 ko:K20881 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 Bacteria COG0637@1,COG0637@2 NA|NA|NA S phosphonoacetaldehyde hydrolase activity MAG.T1.5_00329 330214.NIDE4240 0.0 2124.7 Nitrospirae ko:K02660 ko02020,ko02025,map02020,map02025 ko00000,ko00001,ko02035,ko02044 Bacteria 3J10H@40117,COG0784@1,COG0784@2,COG2202@1,COG2202@2,COG2203@1,COG2203@2,COG4191@1,COG4191@2 NA|NA|NA T Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_00330 330214.NIDE4239 5e-90 337.4 Nitrospirae pmtA Bacteria 3J1DH@40117,COG0500@1,COG2226@2 NA|NA|NA H Methyltransferase domain MAG.T1.5_00331 330214.NIDE4238 0.0 1573.9 Nitrospirae leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 Bacteria 3J0F8@40117,COG0495@1,COG0495@2 NA|NA|NA J Leucyl-tRNA synthetase, Domain 2 MAG.T1.5_00333 330214.NIDE4236 6.9e-169 600.1 Nitrospirae holA GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 3J1EC@40117,COG1466@1,COG1466@2 NA|NA|NA L DNA polymerase III, delta subunit MAG.T1.5_00334 330214.NIDE4235 3.6e-34 150.6 Nitrospirae rpsT GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030234,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0042979,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050790,GO:0065003,GO:0065007,GO:0065009,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02968 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0TS@40117,COG0268@1,COG0268@2 NA|NA|NA J Binds directly to 16S ribosomal RNA MAG.T1.5_00335 330214.NIDE4234 4.5e-108 397.5 Nitrospirae pyrF GO:0003674,GO:0003824,GO:0004590,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 iECO103_1326.ECO103_1444,iECSF_1327.ECSF_1264,iSFV_1184.SFV_1294,iSF_1195.SF1285,iSFxv_1172.SFxv_1457,iS_1188.S1368,ic_1306.c1750 Bacteria 3J0SC@40117,COG0284@1,COG0284@2 NA|NA|NA F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) MAG.T1.5_00340 330214.NIDE4207 4.9e-243 846.7 Bacteria 2.4.1.268 ko:K21349 ko00000,ko01000 GT81 Bacteria COG0463@1,COG0463@2 NA|NA|NA M Glycosyl transferase, family 2 MAG.T1.5_00341 330214.NIDE4206 2.1e-118 431.8 Bacteria cmpX Bacteria COG0668@1,COG0668@2 NA|NA|NA M transmembrane transport MAG.T1.5_00343 330214.NIDE4204 1.4e-105 389.4 Bacteria mpgP GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050897 2.4.1.217,3.1.3.70 ko:K05947,ko:K07026 ko00051,map00051 R05768,R05790 RC00005,RC00017,RC00397,RC02748 ko00000,ko00001,ko01000,ko01003 Bacteria COG3769@1,COG3769@2 NA|NA|NA S mannosylglycerate metabolic process MAG.T1.5_00346 330214.NIDE4201 3.3e-88 331.3 Bacteria sigE ko:K03088 ko00000,ko03021 Bacteria COG1595@1,COG1595@2 NA|NA|NA K DNA-templated transcription, initiation MAG.T1.5_00347 330214.NIDE4200 1.9e-40 171.8 Bacteria Bacteria 2DU53@1,33NYX@2 NA|NA|NA MAG.T1.5_00350 330214.NIDE4197 3.1e-165 587.8 Bacteria Bacteria COG2199@1,COG3706@2 NA|NA|NA T diguanylate cyclase activity MAG.T1.5_00351 330214.NIDE4196 1.1e-142 512.7 Nitrospirae Bacteria 3J0NC@40117,COG1639@1,COG1639@2 NA|NA|NA T HDOD domain MAG.T1.5_00352 1121413.JMKT01000008_gene1088 2.4e-08 65.1 Desulfovibrionales Bacteria 1NJ9J@1224,2EN8Q@1,2MBRD@213115,2WT2P@28221,33FWH@2,42XE1@68525 NA|NA|NA MAG.T1.5_00353 330214.NIDE4194 3.6e-120 437.6 Bacteria WQ51_05710 Bacteria COG2013@1,COG2013@2 NA|NA|NA S Mitochondrial biogenesis AIM24 MAG.T1.5_00354 330214.NIDE4192 1.1e-174 619.4 Nitrospirae Bacteria 3J19Q@40117,COG4783@1,COG4783@2 NA|NA|NA S Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_00355 240015.ACP_0636 3.9e-28 131.3 Acidobacteriia ko:K07095 ko00000 Bacteria 2JJEG@204432,3Y51P@57723,COG0622@1,COG0622@2 NA|NA|NA S Calcineurin-like phosphoesterase superfamily domain MAG.T1.5_00356 671143.DAMO_0159 5.9e-59 233.8 Bacteria Bacteria 2DMP9@1,32SV1@2 NA|NA|NA S Protein of unknown function (DUF3015) MAG.T1.5_00357 330214.NIDE4188 1.7e-306 1058.1 Bacteria Bacteria 28J7E@1,2Z92U@2 NA|NA|NA S Domain of unknown function (DUF4105) MAG.T1.5_00358 697282.Mettu_3255 2.2e-19 101.7 Gammaproteobacteria Bacteria 1NA5N@1224,1SE9F@1236,2E7TI@1,333ZE@2 NA|NA|NA S TRL-like protein family MAG.T1.5_00359 330214.NIDE1885 8.5e-23 114.0 Bacteria ko:K16079 ko00000,ko02000 1.B.4.2.1 Bacteria COG3637@1,COG3637@2 NA|NA|NA M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety MAG.T1.5_00360 330214.NIDE4187 1e-131 476.1 Bacteria mhpC ko:K06889 ko00000 Bacteria COG1073@1,COG1073@2 NA|NA|NA S thiolester hydrolase activity MAG.T1.5_00361 330214.NIDE4185 9.1e-141 506.5 Bacteria vacJ ko:K04754 ko00000 Bacteria COG2853@1,COG2853@2 NA|NA|NA M Lipoprotein MAG.T1.5_00362 330214.NIDE4184 1.7e-189 668.7 Nitrospirae kbl GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0016874,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.29,2.3.1.47 ko:K00639,ko:K00652 ko00260,ko00780,ko01100,map00260,map00780,map01100 M00123,M00573,M00577 R00371,R03210,R10124 RC00004,RC00039,RC00394,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 iECW_1372.ECW_m3896,iEKO11_1354.EKO11_0103,iPC815.YPO0059,iWFL_1372.ECW_m3896 Bacteria 3J0XU@40117,COG0156@1,COG0156@2 NA|NA|NA H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide MAG.T1.5_00363 330214.NIDE4183 1.2e-186 659.1 Bacteria tdh 1.1.1.103,2.7.13.3 ko:K00060,ko:K07777 ko00260,ko02020,map00260,map02020 M00478 R01465 RC00525 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria COG1063@1,COG1063@2 NA|NA|NA E alcohol dehydrogenase MAG.T1.5_00364 330214.NIDE4181 3.7e-137 494.6 Bacteria 2.7.13.3 ko:K03407,ko:K03832 ko02020,ko02030,map02020,map02030 M00506 ko00000,ko00001,ko00002,ko01000,ko01001,ko02000,ko02022,ko02035 2.C.1.1 Bacteria COG0810@1,COG0810@2 NA|NA|NA M energy transducer activity MAG.T1.5_00365 330214.NIDE4180 2e-101 375.2 Bacteria Cj0420 Bacteria COG2353@1,COG2353@2 NA|NA|NA O YceI-like domain MAG.T1.5_00366 330214.NIDE4179 1.4e-99 369.0 Bacteria ko:K03598 ko00000,ko03021 Bacteria COG3026@1,COG3026@2 NA|NA|NA T antisigma factor binding MAG.T1.5_00367 330214.NIDE4178 3.6e-163 580.9 Bacteria Bacteria COG1262@1,COG1262@2 NA|NA|NA T PFAM Formylglycine-generating sulfatase enzyme MAG.T1.5_00368 330214.NIDE4176 1.8e-121 442.2 Bacteria hemD 2.1.1.107,4.2.1.75 ko:K01719,ko:K13542 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165,R03194 RC00003,RC00871,RC01861 ko00000,ko00001,ko00002,ko01000 Bacteria COG1587@1,COG1587@2 NA|NA|NA H uroporphyrinogen-III synthase activity MAG.T1.5_00369 330214.NIDE4175 8.6e-156 556.2 Nitrospirae Bacteria 3J14J@40117,COG1262@1,COG1262@2 NA|NA|NA S Evidence 4 Homologs of previously reported genes of MAG.T1.5_00370 330214.NIDE4174 3.3e-64 251.1 Bacteria Bacteria COG0346@1,COG0346@2 NA|NA|NA E lactoylglutathione lyase activity MAG.T1.5_00371 330214.NIDE4173 1.8e-287 994.6 Bacteria Bacteria COG2220@1,COG2220@2 NA|NA|NA S N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity MAG.T1.5_00372 330214.NIDE4172 4.2e-189 667.2 Nitrospirae capI 5.1.3.6 ko:K08679 ko00520,ko01100,map00520,map01100 R01385 RC00289 ko00000,ko00001,ko01000 Bacteria 3J0ZC@40117,COG0451@1,COG0451@2 NA|NA|NA M Male sterility protein MAG.T1.5_00376 330214.NIDE4168 0.0 1201.8 Nitrospirae kefB ko:K03455 ko00000 2.A.37 Bacteria 3J0Y7@40117,COG0475@1,COG0475@2,COG0490@1,COG0490@2,COG1226@1,COG1226@2 NA|NA|NA P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family MAG.T1.5_00377 330214.NIDE4167 9.3e-195 686.0 Bacteria Bacteria COG4638@1,COG4638@2 NA|NA|NA P Rieske (2fe-2S) MAG.T1.5_00378 330214.NIDE4166 5.7e-89 333.6 Bacteria cdr ko:K04085 ko04122,map04122 ko00000,ko00001,ko01000,ko03016 Bacteria COG2210@1,COG2210@2 NA|NA|NA P Belongs to the sulfur carrier protein TusA family MAG.T1.5_00379 330214.NIDE4165 9.8e-36 155.6 Nitrospirae 1.8.7.1 ko:K00392 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00859,R03600 RC00065 ko00000,ko00001,ko00002,ko01000 Bacteria 3J1C1@40117,COG0425@1,COG0425@2 NA|NA|NA O Sulfurtransferase TusA MAG.T1.5_00380 330214.NIDE4164 3.4e-230 804.3 Bacteria ftcD 2.1.2.5,4.3.1.4 ko:K00603,ko:K01746,ko:K13990 ko00340,ko00670,ko01100,map00340,map00670,map01100 R02287,R02302,R03189 RC00165,RC00221,RC00223,RC00688,RC00870 ko00000,ko00001,ko01000,ko03036,ko04147 Bacteria COG3404@1,COG3404@2,COG3643@1,COG3643@2 NA|NA|NA E Formiminotransferase domain MAG.T1.5_00381 330214.NIDE4163 3.4e-23 113.6 Bacteria rpsU GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 ko:K02970 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria COG0828@1,COG0828@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bS21 family MAG.T1.5_00382 330214.NIDE4162 1.8e-108 398.7 Nitrospirae nth GO:0000702,GO:0000703,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006289,GO:0006296,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033683,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.11.2,4.2.99.18 ko:K01142,ko:K10773 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 3J0K6@40117,COG0177@1,COG0177@2 NA|NA|NA L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate MAG.T1.5_00383 330214.NIDE4161 9.5e-63 246.1 Bacteria Bacteria COG2210@1,COG2210@2 NA|NA|NA P Belongs to the sulfur carrier protein TusA family MAG.T1.5_00385 330214.NIDE4159 6.6e-67 260.0 Bacteria Bacteria 2E4SV@1,32ZM7@2 NA|NA|NA MAG.T1.5_00386 330214.NIDE4158 0.0 1501.1 Nitrospirae polA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7,3.1.26.4 ko:K02335,ko:K03469 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 Bacteria 3J0DP@40117,COG0258@1,COG0258@2,COG0749@1,COG0749@2 NA|NA|NA L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity MAG.T1.5_00387 330214.NIDE4157 2.6e-59 234.6 Bacteria Bacteria COG3824@1,COG3824@2 NA|NA|NA S Zincin-like metallopeptidase MAG.T1.5_00389 330214.NIDE4155 3.7e-219 767.3 Bacteria Bacteria 293H1@1,2ZQZ6@2 NA|NA|NA MAG.T1.5_00391 330214.NIDE3510 9e-40 171.4 Bacteria Bacteria 2DT3N@1,33IIR@2 NA|NA|NA MAG.T1.5_00392 330214.NIDE4152 5.7e-165 587.0 Bacteria Bacteria COG1524@1,COG1524@2 NA|NA|NA S mannose-ethanolamine phosphotransferase activity MAG.T1.5_00394 330214.NIDE4150 5e-113 414.8 Nitrospirae Bacteria 3J1E2@40117,COG1413@1,COG1413@2 NA|NA|NA C Evidence 4 Homologs of previously reported genes of MAG.T1.5_00395 330214.NIDE4149 1.5e-160 572.4 Nitrospirae Bacteria 3J1E2@40117,COG1413@1,COG1413@2 NA|NA|NA C Evidence 4 Homologs of previously reported genes of MAG.T1.5_00396 330214.NIDE4148 2e-165 588.6 Bacteria Bacteria COG1413@1,COG1413@2 NA|NA|NA C deoxyhypusine monooxygenase activity MAG.T1.5_00397 330214.NIDE4147 3.1e-19 102.4 Nitrospirae Bacteria 3J1E2@40117,COG1413@1,COG1413@2 NA|NA|NA C Evidence 4 Homologs of previously reported genes of MAG.T1.5_00398 330214.NIDE4146 3.8e-88 331.3 Bacteria Bacteria COG1413@1,COG1413@2 NA|NA|NA C deoxyhypusine monooxygenase activity MAG.T1.5_00399 330214.NIDE4145 5.9e-244 849.7 Nitrospirae rkpK GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0EJ@40117,COG1004@1,COG1004@2 NA|NA|NA C Belongs to the UDP-glucose GDP-mannose dehydrogenase family MAG.T1.5_00400 330214.NIDE4144 9e-58 229.6 Bacteria opuCA 2.7.7.7 ko:K02342,ko:K05847,ko:K07182 ko00230,ko00240,ko01100,ko02010,ko03030,ko03430,ko03440,map00230,map00240,map01100,map02010,map03030,map03430,map03440 M00209,M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko02000,ko03032,ko03400 3.A.1.12 Bacteria COG2905@1,COG2905@2 NA|NA|NA T signal-transduction protein containing cAMP-binding and CBS domains MAG.T1.5_00401 330214.NIDE4143 1.2e-267 928.7 Bacteria speE 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 Bacteria COG0421@1,COG0421@2 NA|NA|NA E spermidine synthase activity MAG.T1.5_00404 330214.NIDE4140 2.7e-63 247.7 Nitrospirae yfhL ko:K03522,ko:K05337 ko00000,ko04147 Bacteria 3J1BF@40117,COG1145@1,COG1145@2 NA|NA|NA C 4Fe-4S dicluster domain MAG.T1.5_00405 330214.NIDE4139 4e-76 290.8 Bacteria ko:K09005 ko00000 Bacteria COG1430@1,COG1430@2 NA|NA|NA S Uncharacterized ACR, COG1430 MAG.T1.5_00406 330214.NIDE4138 1.1e-52 212.2 Nitrospirae 1.7.1.15 ko:K00363,ko:K05710 ko00360,ko00910,ko01120,ko01220,map00360,map00910,map01120,map01220 M00530,M00545 R00787,R06782,R06783 RC00098,RC00176 br01602,ko00000,ko00001,ko00002,ko01000 Bacteria 3J1E7@40117,COG2146@1,COG2146@2 NA|NA|NA P Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_00408 330214.NIDE4136 1.1e-121 443.0 Bacteria dat GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016769,GO:0019478,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0046416,GO:0046437,GO:0047810,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.6.1.21 ko:K00824 ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100 R01148,R01582,R02459,R02851,R02924,R05053 RC00006,RC00008,RC00025 ko00000,ko00001,ko01000,ko01007 Bacteria COG0115@1,COG0115@2 NA|NA|NA E branched-chain-amino-acid transaminase activity MAG.T1.5_00409 330214.NIDE4135 2.9e-69 268.1 Nitrospirae rimP GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576 ko:K09748 ko00000,ko03009 Bacteria 3J0UD@40117,COG0779@1,COG0779@2 NA|NA|NA J Required for maturation of 30S ribosomal subunits MAG.T1.5_00410 330214.NIDE4134 5e-199 700.3 Nitrospirae nusA GO:0001000,GO:0001121,GO:0001125,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 ko:K02600 ko00000,ko03009,ko03021 Bacteria 3J0DF@40117,COG0195@1,COG0195@2 NA|NA|NA K Participates in both transcription termination and antitermination MAG.T1.5_00411 330214.NIDE4133 0.0 1348.2 Nitrospirae infB ko:K02519 ko00000,ko03012,ko03029 Bacteria 3J0CC@40117,COG0532@1,COG0532@2 NA|NA|NA J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex MAG.T1.5_00412 330214.NIDE4132 6.4e-39 166.4 Bacteria ylxP ko:K09764 ko00000 Bacteria COG1550@1,COG1550@2 NA|NA|NA H Protein conserved in bacteria MAG.T1.5_00413 330214.NIDE4131 5.9e-46 190.3 Nitrospirae rbfA GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0030490,GO:0033554,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043021,GO:0043024,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071840,GO:0090304,GO:1901360 ko:K02834 ko00000,ko03009 Bacteria 3J0VV@40117,COG0858@1,COG0858@2 NA|NA|NA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA MAG.T1.5_00414 330214.NIDE4130 2.2e-137 495.4 Nitrospirae truB GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 ko:K03177,ko:K03483 ko00000,ko01000,ko03000,ko03016 iSB619.SA_RS06305 Bacteria 3J0KH@40117,COG0130@1,COG0130@2 NA|NA|NA J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs MAG.T1.5_00415 330214.NIDE4129 1e-38 165.6 Nitrospirae rpsO GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006378,GO:0006396,GO:0006397,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016071,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031123,GO:0031124,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043631,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02956 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0RA@40117,COG0184@1,COG0184@2 NA|NA|NA J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome MAG.T1.5_00416 330214.NIDE4127 0.0 1296.2 Nitrospirae pnp GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 Bacteria 3J0DX@40117,COG1185@1,COG1185@2 NA|NA|NA J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction MAG.T1.5_00417 330214.NIDE4126 2.1e-219 768.1 Nitrospirae pepR GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 3J0GS@40117,COG0612@1,COG0612@2 NA|NA|NA S Insulinase (Peptidase family M16) MAG.T1.5_00420 330214.NIDE4122 0.0 1436.0 Nitrospirae mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 ko:K03555 ko03430,map03430 ko00000,ko00001,ko03400 Bacteria 3J0CE@40117,COG0249@1,COG0249@2 NA|NA|NA L that it carries out the mismatch recognition step. This protein has a weak ATPase activity MAG.T1.5_00422 330214.NIDE4120 1.5e-67 262.7 Nitrospirae yjeE 2.7.1.221 ko:K06925,ko:K07102 ko00520,ko01100,map00520,map01100 R08968,R11024 RC00002,RC00078 ko00000,ko00001,ko01000,ko03016 Bacteria 3J1AZ@40117,COG0802@1,COG0802@2 NA|NA|NA S Threonylcarbamoyl adenosine biosynthesis protein TsaE MAG.T1.5_00423 330214.NIDE4119 9.4e-244 849.4 Nitrospirae nnrD GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0052855,GO:0052856,GO:0052857 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 ko00000,ko01000 Bacteria 3J0J1@40117,COG0062@1,COG0062@2,COG0063@1,COG0063@2 NA|NA|NA H Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration MAG.T1.5_00424 330214.NIDE4117 2.4e-122 444.9 Nitrospirae pdxJ GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 ko:K03474 ko00750,ko01100,map00750,map01100 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000 iAF1260.b2564,iAF987.Gmet_1885,iB21_1397.B21_02422,iBWG_1329.BWG_2328,iEC55989_1330.EC55989_2852,iECBD_1354.ECBD_1117,iECB_1328.ECB_02458,iECDH10B_1368.ECDH10B_2732,iECDH1ME8569_1439.ECDH1ME8569_2491,iECD_1391.ECD_02458,iECH74115_1262.ECH74115_3800,iECIAI1_1343.ECIAI1_2675,iECO103_1326.ECO103_3142,iECO111_1330.ECO111_3290,iECO26_1355.ECO26_3611,iECSE_1348.ECSE_2852,iECSP_1301.ECSP_3509,iECW_1372.ECW_m2792,iECs_1301.ECs3430,iEKO11_1354.EKO11_1169,iEcDH1_1363.EcDH1_1104,iEcE24377_1341.EcE24377A_2850,iEcHS_1320.EcHS_A2719,iEcolC_1368.EcolC_1113,iG2583_1286.G2583_3145,iJO1366.b2564,iJR904.b2564,iWFL_1372.ECW_m2792,iY75_1357.Y75_RS13390 Bacteria 3J0KZ@40117,COG0854@1,COG0854@2 NA|NA|NA H Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate MAG.T1.5_00425 330214.NIDE4115 2.3e-231 807.7 Nitrospirae yfdZ GO:0003674,GO:0003824,GO:0004021,GO:0006082,GO:0006090,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009078,GO:0009079,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019272,GO:0019752,GO:0030632,GO:0032787,GO:0042851,GO:0042852,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0047635,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.83 ko:K10206,ko:K14261 ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230 M00527 R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 iEcSMS35_1347.EcSMS35_2531,iSBO_1134.SBO_2405 Bacteria 3J0ED@40117,COG0436@1,COG0436@2 NA|NA|NA E Aminotransferase class I and II MAG.T1.5_00426 330214.NIDE4114 4.2e-226 790.4 Nitrospirae hom GO:0003674,GO:0003824,GO:0004412,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.3,2.2.1.6 ko:K00003,ko:K01653 ko00260,ko00270,ko00290,ko00300,ko00650,ko00660,ko00770,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00270,map00290,map00300,map00650,map00660,map00770,map01100,map01110,map01120,map01130,map01210,map01230 M00017,M00018,M00019,M00570 R00006,R00014,R00226,R01773,R01775,R03050,R04672,R04673,R08648 RC00027,RC00087,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1294,iSB619.SA_RS06610 Bacteria 3J0G1@40117,COG0440@1,COG0440@2,COG0460@1,COG0460@2 NA|NA|NA E Homoserine dehydrogenase MAG.T1.5_00427 330214.NIDE4113 4.5e-186 657.1 Nitrospirae thrC GO:0003674,GO:0003824,GO:0004795,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 iLJ478.TM0546,iSB619.SA_RS06615,iYO844.BSU32250 Bacteria 3J0FI@40117,COG0498@1,COG0498@2 NA|NA|NA E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine MAG.T1.5_00428 330214.NIDE4112 4.8e-203 713.8 Nitrospirae apgM 5.4.2.12 ko:K15635 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0YA@40117,COG3635@1,COG3635@2 NA|NA|NA G Metalloenzyme superfamily MAG.T1.5_00429 330214.NIDE4111 1.4e-207 728.8 Nitrospirae lysC GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.3,2.7.2.4 ko:K00928,ko:K12524 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480,R01773,R01775 RC00002,RC00043,RC00087 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0AZ@40117,COG0527@1,COG0527@2 NA|NA|NA E ACT domain MAG.T1.5_00430 330214.NIDE4110 6.1e-288 996.1 Nitrospirae leuA2 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 3J0DC@40117,COG0119@1,COG0119@2 NA|NA|NA E Belongs to the alpha-IPM synthase homocitrate synthase family MAG.T1.5_00431 330214.NIDE4109 3.8e-42 177.2 Nitrospirae himA GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 ko:K04764,ko:K05788 ko00000,ko03032,ko03036,ko03400 Bacteria 3J1CY@40117,COG0776@1,COG0776@2 NA|NA|NA L bacterial (prokaryotic) histone like domain MAG.T1.5_00432 330214.NIDE4108 7.2e-56 223.0 Nitrospirae ycgE ko:K19591,ko:K22491 M00769 ko00000,ko00002,ko01504,ko03000 Bacteria 3J0VF@40117,COG0789@1,COG0789@2 NA|NA|NA K helix_turn_helix, mercury resistance MAG.T1.5_00434 330214.NIDE4107 9e-126 456.4 Nitrospirae surE GO:0003674,GO:0003824,GO:0004309,GO:0005488,GO:0005515,GO:0006139,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008254,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009125,GO:0009129,GO:0009131,GO:0009158,GO:0009161,GO:0009164,GO:0009166,GO:0009173,GO:0009175,GO:0009218,GO:0009222,GO:0009259,GO:0009261,GO:0009987,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030145,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042578,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046049,GO:0046050,GO:0046131,GO:0046133,GO:0046135,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 iSFxv_1172.SFxv_3035 Bacteria 3J0IG@40117,COG0496@1,COG0496@2 NA|NA|NA S Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates MAG.T1.5_00435 330214.NIDE4106 5.8e-112 410.2 Bacteria dedA Bacteria COG0586@1,COG0586@2 NA|NA|NA S FtsZ-dependent cytokinesis MAG.T1.5_00436 330214.NIDE4105 1.4e-241 842.0 Nitrospirae cysS GO:0000166,GO:0001871,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030246,GO:0030247,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065 6.1.1.16,6.3.1.13 ko:K01883,ko:K15526 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iECUMN_1333.ECUMN_0566,iJN746.PP_2905 Bacteria 3J0CM@40117,COG0215@1,COG0215@2 NA|NA|NA J DALR_2 MAG.T1.5_00437 330214.NIDE4104 9.2e-112 409.8 Nitrospirae rlmB 2.1.1.185 ko:K03218,ko:K03437 ko00000,ko01000,ko03009,ko03016 Bacteria 3J0RH@40117,COG0566@1,COG0566@2 NA|NA|NA J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family MAG.T1.5_00438 330214.NIDE4103 2.5e-35 154.5 Bacteria ko:K03413 ko02020,ko02030,map02020,map02030 M00506 ko00000,ko00001,ko00002,ko02022,ko02035 Bacteria COG2197@1,COG2197@2 NA|NA|NA K response regulator MAG.T1.5_00439 330214.NIDE4102 2.1e-116 425.2 Nitrospirae pilD 3.4.23.43 ko:K02278,ko:K02654 M00331 ko00000,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15.2 Bacteria 3J0SK@40117,COG1989@1,COG1989@2 NA|NA|NA NOU Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue MAG.T1.5_00440 330214.NIDE4101 1.8e-48 198.7 Bacteria VP0657 ko:K02457,ko:K02672,ko:K08084,ko:K08085 ko03070,ko05111,map03070,map05111 M00331 ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 Bacteria COG4970@1,COG4970@2 NA|NA|NA NU protein transport across the cell outer membrane MAG.T1.5_00441 330214.NIDE4100 2.8e-64 251.5 Bacteria comGF ko:K02246,ko:K02248 M00429 ko00000,ko00002,ko02044 Bacteria COG4940@1,COG4940@2 NA|NA|NA U Putative Competence protein ComGF MAG.T1.5_00442 330214.NIDE4099 1.3e-78 299.7 Bacteria ko:K02672 ko00000,ko02035,ko02044 Bacteria COG4966@1,COG4966@2 NA|NA|NA NU pilus assembly protein PilW MAG.T1.5_00443 330214.NIDE4098 1.5e-214 752.3 Bacteria ko:K07140 ko00000 Bacteria COG3217@1,COG3217@2,COG4726@1,COG4726@2 NA|NA|NA NU Pilus assembly protein PilX MAG.T1.5_00444 330214.NIDE4097 1.2e-271 942.2 Nitrospirae gspE2 ko:K02652 ko00000,ko02035,ko02044 3.A.15.2 Bacteria 3J0XR@40117,COG2804@1,COG2804@2 NA|NA|NA NU Type II/IV secretion system protein MAG.T1.5_00445 330214.NIDE4096 1.2e-58 232.6 Bacteria Bacteria COG4970@1,COG4970@2 NA|NA|NA NU protein transport across the cell outer membrane MAG.T1.5_00446 330214.NIDE4095 4.5e-62 244.2 Bacteria ppdC ko:K02671,ko:K02681,ko:K10927 ko05111,map05111 ko00000,ko00001,ko02035,ko02044 Bacteria COG4967@1,COG4967@2 NA|NA|NA NU type IV pilus modification protein PilV MAG.T1.5_00447 330214.NIDE4094 2.1e-162 578.6 Bacteria ko:K02672 ko00000,ko02035,ko02044 Bacteria COG4966@1,COG4966@2 NA|NA|NA NU pilus assembly protein PilW MAG.T1.5_00450 330214.NIDE4091 0.0 2684.8 Nitrospirae pilY1-2 ko:K02674 ko00000,ko02035,ko02044 Bacteria 3J100@40117,COG3419@1,COG3419@2 NA|NA|NA NU Tfp pilus assembly protein tip-associated adhesin MAG.T1.5_00451 330214.NIDE4090 1.6e-121 442.6 Bacteria Bacteria COG3209@1,COG3209@2 NA|NA|NA M self proteolysis MAG.T1.5_00452 330214.NIDE4089 1.6e-170 605.5 Nitrospirae phoH GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K06217 ko00000 Bacteria 3J0AD@40117,COG1702@1,COG1702@2 NA|NA|NA T PhoH-like protein MAG.T1.5_00453 330214.NIDE4088 1e-54 219.5 Nitrospirae ybeY GO:0000469,GO:0000478,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006355,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016072,GO:0016151,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0019219,GO:0019222,GO:0019538,GO:0022613,GO:0030490,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043244,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141 2.6.99.2,3.5.4.5 ko:K01489,ko:K03474,ko:K03595,ko:K07042 ko00240,ko00750,ko00983,ko01100,map00240,map00750,map00983,map01100 M00124 R01878,R02485,R05838,R08221 RC00074,RC00514,RC01476 ko00000,ko00001,ko00002,ko01000,ko03009,ko03029 Bacteria 3J0US@40117,COG0319@1,COG0319@2 NA|NA|NA J Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA MAG.T1.5_00454 330214.NIDE4087 5.7e-153 547.0 Nitrospirae ftsY GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019897,GO:0019898,GO:0031224,GO:0031226,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033036,GO:0033365,GO:0034613,GO:0035639,GO:0036094,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363 ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 Bacteria 3J0GY@40117,COG0552@1,COG0552@2 NA|NA|NA D Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) MAG.T1.5_00455 330214.NIDE4086 5.4e-120 437.2 Bacteria Bacteria COG0745@1,COG0745@2,COG2204@1,COG2204@2 NA|NA|NA T phosphorelay signal transduction system MAG.T1.5_00456 330214.NIDE4085 0.0 1089.3 Bacteria iAF987.Gmet_0348 Bacteria COG0308@1,COG0308@2 NA|NA|NA E peptide catabolic process MAG.T1.5_00457 330214.NIDE4084 3.6e-173 614.4 Bacteria tolB ko:K03641 ko00000,ko02000 2.C.1.2 Bacteria COG0823@1,COG0823@2 NA|NA|NA U Involved in the tonB-independent uptake of proteins MAG.T1.5_00458 330214.NIDE4083 5.8e-112 411.0 Nitrospirae lpxE 3.1.3.27,3.1.3.4,3.1.3.81,3.6.1.27 ko:K01096,ko:K19302 ko00550,ko00564,ko01100,map00550,map00564,map01100 R02029,R05627 RC00002,RC00017 ko00000,ko00001,ko01000,ko01011 Bacteria 3J1CX@40117,COG0671@1,COG0671@2 NA|NA|NA I PAP2 superfamily MAG.T1.5_00459 330214.NIDE4082 1.6e-305 1054.7 Nitrospirae Bacteria 3J12H@40117,COG1807@1,COG1807@2 NA|NA|NA M Dolichyl-phosphate-mannose-protein mannosyltransferase MAG.T1.5_00460 330214.NIDE4081 2.2e-45 188.0 Bacteria Bacteria COG3952@1,COG3952@2 NA|NA|NA S lipid-A-disaccharide synthase activity MAG.T1.5_00461 330214.NIDE4080 9.3e-125 453.0 Nitrospirae arnC 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 R01009 RC00005 ko00000,ko00001,ko01000,ko01003 GT2 Bacteria 3J13C@40117,COG0463@1,COG0463@2 NA|NA|NA M Glycosyltransferase like family 2 MAG.T1.5_00462 330214.NIDE4079 2.6e-268 931.0 Bacteria ko:K02021 ko00000,ko02000 3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21 Bacteria COG2274@1,COG2274@2 NA|NA|NA V protein secretion by the type I secretion system MAG.T1.5_00463 330214.NIDE4078 9.3e-106 389.8 Bacteria ko:K07090 ko00000 Bacteria 29802@1,2ZV65@2 NA|NA|NA MAG.T1.5_00465 330214.NIDE4076 2.2e-247 861.3 Bacteria truB 1.9.3.1,2.7.7.13,3.2.1.97,5.4.99.25 ko:K00412,ko:K00971,ko:K02275,ko:K02389,ko:K03177,ko:K17624 ko00051,ko00190,ko00520,ko01100,ko01110,ko02020,ko02040,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00051,map00190,map00520,map01100,map01110,map02020,map02040,map04260,map04714,map04932,map05010,map05012,map05016 M00114,M00151,M00152,M00155,M00361,M00362 R00081,R00885 RC00002,RC00016 ko00000,ko00001,ko00002,ko01000,ko02035,ko03016,ko03029 3.D.4.2,3.D.4.4,3.D.4.6 GH101 Bacteria COG1565@1,COG1565@2 NA|NA|NA P acr, cog1565 MAG.T1.5_00467 330214.NIDE4075 3.8e-31 140.6 Nitrospirae tatA ko:K03116 ko03060,ko03070,map03060,map03070 M00336 ko00000,ko00001,ko00002,ko02044 2.A.64 Bacteria 3J1A4@40117,COG1826@1,COG1826@2 NA|NA|NA U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system MAG.T1.5_00468 330214.NIDE4074 1.1e-25 122.5 Bacteria tatB GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0040007,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 ko:K03116,ko:K03117 ko03060,ko03070,map03060,map03070 M00336 ko00000,ko00001,ko00002,ko02044 2.A.64 Bacteria COG1826@1,COG1826@2 NA|NA|NA U protein secretion MAG.T1.5_00469 330214.NIDE4073 2.5e-308 1063.9 Bacteria VPA1441 Bacteria COG3203@1,COG3203@2 NA|NA|NA M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane MAG.T1.5_00471 330214.NIDE4071 1.8e-286 991.5 Bacteria 3.6.4.12 ko:K03654 ko03018,map03018 ko00000,ko00001,ko01000,ko03400 Bacteria COG0514@1,COG0514@2 NA|NA|NA L ATP-dependent DNA helicase (RecQ) MAG.T1.5_00472 330214.NIDE4070 1e-105 389.4 Bacteria thrH 2.7.1.39,3.1.3.3 ko:K02203 ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00680,map01100,map01110,map01120,map01130,map01230 M00018 R00582,R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria COG0560@1,COG0560@2 NA|NA|NA E Phosphoserine phosphatase MAG.T1.5_00473 330214.NIDE4069 3.1e-110 404.8 Bacteria Bacteria COG0727@1,COG0727@2 NA|NA|NA S metal cluster binding MAG.T1.5_00475 330214.NIDE4067 5.3e-110 404.1 Nitrospirae Bacteria 3J1BM@40117,COG1434@1,COG1434@2 NA|NA|NA S DUF218 domain MAG.T1.5_00476 330214.NIDE4066 2.7e-69 268.1 Bacteria MA20_25125 Bacteria COG2947@1,COG2947@2 NA|NA|NA L Ubiquinol--cytochrome c reductase MAG.T1.5_00478 330214.NIDE4064 1.2e-119 436.0 Nitrospirae yaaT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 Bacteria 3J0MI@40117,COG1774@1,COG1774@2 NA|NA|NA S PSP1 C-terminal conserved region MAG.T1.5_00479 330214.NIDE4063 8.8e-177 626.3 Bacteria lysDH 1.5.1.7 ko:K00290 ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230 M00030,M00032 R00715 RC00217,RC01532 ko00000,ko00001,ko00002,ko01000 Bacteria COG1748@1,COG1748@2 NA|NA|NA E saccharopine dehydrogenase activity MAG.T1.5_00480 330214.NIDE4062 9.7e-246 855.9 Bacteria pcd GO:0003674,GO:0003824,GO:0004029,GO:0006081,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0044237,GO:0055114,GO:0071704 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 Bacteria COG1012@1,COG1012@2 NA|NA|NA C belongs to the aldehyde dehydrogenase family MAG.T1.5_00481 330214.NIDE4061 6.4e-89 333.6 Bacteria ko:K08234 ko00000 Bacteria COG0346@1,COG0346@2 NA|NA|NA E lactoylglutathione lyase activity MAG.T1.5_00482 330214.NIDE4060 4.8e-21 107.5 Nitrospirae mauG GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.11.1.5 ko:K00428 ko00000,ko01000 Bacteria 3J0GH@40117,COG1858@1,COG1858@2 NA|NA|NA C Di-haem cytochrome c peroxidase MAG.T1.5_00483 886293.Sinac_0436 1.7e-13 82.8 Planctomycetes Bacteria 2C5IF@1,2IZWG@203682,2Z9B7@2 NA|NA|NA S Protein of unknown function (DUF1264) MAG.T1.5_00484 330214.NIDE4057 8.6e-46 189.9 Bacteria Bacteria COG2010@1,COG2010@2 NA|NA|NA C Cytochrome c MAG.T1.5_00485 330214.NIDE1463 8.2e-22 109.0 Nitrospirae istB Bacteria 3J0QU@40117,COG1484@1,COG1484@2 NA|NA|NA L Evidence 2b Function of strongly homologous gene MAG.T1.5_00490 330214.NIDE4050 7.3e-64 250.4 Bacteria ko:K06940 ko00000 Bacteria COG0727@1,COG0727@2 NA|NA|NA S metal cluster binding MAG.T1.5_00491 330214.NIDE4049 1.3e-91 342.4 Bacteria Bacteria 2BXN6@1,2ZK04@2 NA|NA|NA MAG.T1.5_00492 330214.NIDE4047 3.3e-43 180.6 Bacteria hup ko:K03530 ko00000,ko03032,ko03036,ko03400 Bacteria COG0776@1,COG0776@2 NA|NA|NA L regulation of translation MAG.T1.5_00493 330214.NIDE4045 3e-41 174.1 Bacteria moaD ko:K03636 ko04122,map04122 ko00000,ko00001 Bacteria COG1977@1,COG1977@2 NA|NA|NA H Mo-molybdopterin cofactor metabolic process MAG.T1.5_00495 330214.NIDE4043 9.6e-95 352.8 Nitrospirae rfbC 5.1.3.13 ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R06514 RC01531 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0K0@40117,COG1898@1,COG1898@2 NA|NA|NA M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose MAG.T1.5_00496 330214.NIDE4042 4.4e-58 230.7 Nitrospirae ko:K09825 ko00000,ko03000 Bacteria 3J1CV@40117,COG0735@1,COG0735@2 NA|NA|NA L Ferric uptake regulator family MAG.T1.5_00497 330214.NIDE4041 1.3e-75 288.9 Nitrospirae rbr Bacteria 3J0RY@40117,COG1592@1,COG1592@2 NA|NA|NA C Rubrerythrin MAG.T1.5_00498 330214.NIDE4040 4.2e-210 737.3 Bacteria glpC GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0045333,GO:0046872,GO:0048037,GO:0051536,GO:0051540,GO:0055114,GO:0071944 1.1.5.3,1.2.7.3 ko:K00113,ko:K00176,ko:K05524,ko:K13795,ko:K13796 ko00020,ko00564,ko00720,ko01100,ko01110,ko01120,ko01200,map00020,map00564,map00720,map01100,map01110,map01120,map01200 M00009,M00011,M00173,M00620 R00848,R01197 RC00004,RC00029,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria COG0247@1,COG0247@2,COG1146@1,COG1146@2 NA|NA|NA C 4 iron, 4 sulfur cluster binding MAG.T1.5_00499 330214.NIDE4039 6.3e-81 307.0 Nitrospirae Bacteria 3J187@40117,COG0247@1,COG0247@2 NA|NA|NA C Protein of unknown function (DUF3501) MAG.T1.5_00500 330214.NIDE4038 1.8e-128 465.3 Nitrospirae 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 Bacteria 3J0TW@40117,COG0720@1,COG0720@2 NA|NA|NA H 6-pyruvoyl tetrahydropterin synthase MAG.T1.5_00502 330214.NIDE4037 4.7e-179 634.0 Bacteria ko:K02004,ko:K06994 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria COG1511@1,COG1511@2 NA|NA|NA Q domain protein MAG.T1.5_00503 330214.NIDE4036 3.5e-100 371.3 Bacteria ko:K02487,ko:K12543 ko02020,map02020 M00330,M00507 ko00000,ko00001,ko00002,ko02000,ko02022,ko02035,ko02044 1.B.17,3.A.1.109.4 Bacteria COG2885@1,COG2885@2 NA|NA|NA M chlorophyll binding MAG.T1.5_00504 330214.NIDE4035 2.9e-111 408.3 Bacteria Bacteria COG1262@1,COG1262@2 NA|NA|NA T PFAM Formylglycine-generating sulfatase enzyme MAG.T1.5_00505 330214.NIDE4034 1.5e-55 221.9 Bacteria bta 1.8.1.8 ko:K03671,ko:K03672 ko04621,ko05418,map04621,map05418 ko00000,ko00001,ko01000,ko03110 Bacteria COG0526@1,COG0526@2 NA|NA|NA CO cell redox homeostasis MAG.T1.5_00506 330214.NIDE4033 4.6e-82 310.5 Nitrospirae 1.11.1.15 ko:K03564 ko00000,ko01000 Bacteria 3J12D@40117,COG1225@1,COG1225@2 NA|NA|NA O AhpC/TSA family MAG.T1.5_00508 330214.NIDE4031 0.0 1164.4 Nitrospirae typA GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840 ko:K06207 ko00000 Bacteria 3J10A@40117,COG1217@1,COG1217@2 NA|NA|NA T Elongation factor G C-terminus MAG.T1.5_00509 330214.NIDE4030 0.0 1511.1 Nitrospirae mrcA GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 ko00000,ko00001,ko01000,ko01003,ko01011 GT51 iAF987.Gmet_0354 Bacteria 3J0BH@40117,COG5009@1,COG5009@2 NA|NA|NA M Penicillin-binding protein OB-like domain MAG.T1.5_00510 330214.NIDE4029 6.9e-30 136.0 Nitrospirae iscX GO:0003674,GO:0004857,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0030234,GO:0031163,GO:0043086,GO:0043167,GO:0043169,GO:0044085,GO:0044092,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050790,GO:0051186,GO:0065007,GO:0065009,GO:0071840,GO:0098772 Bacteria 3J1CR@40117,COG2975@1,COG2975@2 NA|NA|NA S Iron-sulphur cluster assembly MAG.T1.5_00511 330214.NIDE4028 7.5e-306 1055.8 Nitrospirae ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 Bacteria 3J0YD@40117,COG0443@1,COG0443@2 NA|NA|NA O Hsp70 protein MAG.T1.5_00512 330214.NIDE4027 1.7e-83 315.8 Nitrospirae hscB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051604,GO:0071704,GO:0097428,GO:1901564,GO:1902494,GO:1990230,GO:1990234 ko:K04082,ko:K05801 ko00000,ko03029,ko03110 Bacteria 3J1CS@40117,COG1076@1,COG1076@2 NA|NA|NA O DnaJ molecular chaperone homology domain MAG.T1.5_00513 330214.NIDE4026 8.4e-60 236.1 Nitrospirae ycf57 GO:0003674,GO:0005488,GO:0005506,GO:0005515,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051540,GO:0051604,GO:0071704,GO:0071840,GO:0097428,GO:1901564 ko:K13628 ko00000,ko03016 Bacteria 3J17Y@40117,COG0316@1,COG0316@2 NA|NA|NA S Iron-sulphur cluster biosynthesis MAG.T1.5_00514 330214.NIDE4025 1.4e-65 255.4 Nitrospirae iscU GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0019538,GO:0019725,GO:0022607,GO:0030003,GO:0031163,GO:0036455,GO:0042592,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0071840,GO:0097428,GO:0098771,GO:1901564 ko:K04488 ko00000 iAPECO1_1312.APECO1_3996,iB21_1397.B21_02385,iBWG_1329.BWG_2293,iE2348C_1286.E2348C_2812,iEC042_1314.EC042_2733,iEC55989_1330.EC55989_2814,iECABU_c1320.ECABU_c28350,iECBD_1354.ECBD_1155,iECB_1328.ECB_02421,iECDH10B_1368.ECDH10B_2696,iECDH1ME8569_1439.ECDH1ME8569_2456,iECD_1391.ECD_02421,iECED1_1282.ECED1_2960,iECH74115_1262.ECH74115_3761,iECIAI1_1343.ECIAI1_2581,iECIAI39_1322.ECIAI39_2730,iECNA114_1301.ECNA114_2608,iECO103_1326.ECO103_3046,iECO111_1330.ECO111_3253,iECO26_1355.ECO26_3576,iECOK1_1307.ECOK1_2878,iECP_1309.ECP_2534,iECS88_1305.ECS88_2705,iECSE_1348.ECSE_2815,iECSF_1327.ECSF_2373,iECSP_1301.ECSP_3473,iECUMN_1333.ECUMN_2849,iECW_1372.ECW_m2755,iECs_1301.ECs3395,iEKO11_1354.EKO11_1204,iETEC_1333.ETEC_2686,iEcDH1_1363.EcDH1_1139,iEcE24377_1341.EcE24377A_2814,iEcHS_1320.EcHS_A2680,iEcSMS35_1347.EcSMS35_2682,iEcolC_1368.EcolC_1148,iG2583_1286.G2583_3059,iJO1366.b2529,iSDY_1059.SDY_2725,iSFV_1184.SFV_2577,iSF_1195.SF2576,iSFxv_1172.SFxv_2832,iSSON_1240.SSON_2611,iS_1188.S2748,iUMN146_1321.UM146_04055,iUMNK88_1353.UMNK88_3182,iUTI89_1310.UTI89_C2851,iWFL_1372.ECW_m2755,iY75_1357.Y75_RS13200,iZ_1308.Z3796,ic_1306.c3055 Bacteria 3J123@40117,COG0822@1,COG0822@2 NA|NA|NA C A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters MAG.T1.5_00515 330214.NIDE4024 6.9e-223 779.6 Nitrospirae iscS GO:0001522,GO:0003674,GO:0003824,GO:0004123,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006790,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009000,GO:0009058,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016226,GO:0016740,GO:0016769,GO:0016782,GO:0016783,GO:0016829,GO:0016846,GO:0018130,GO:0018131,GO:0019842,GO:0022607,GO:0030170,GO:0031071,GO:0031119,GO:0031163,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046484,GO:0048037,GO:0050662,GO:0051186,GO:0070279,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097163,GO:0140104,GO:1901360,GO:1901363 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 iPC815.YPO2896,iYL1228.KPN_02862 Bacteria 3J0AX@40117,COG1104@1,COG1104@2 NA|NA|NA E Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins MAG.T1.5_00516 330214.NIDE4023 1.4e-81 308.9 Nitrospirae rrf2 Bacteria 3J18M@40117,COG1959@1,COG1959@2 NA|NA|NA K Transcriptional regulator MAG.T1.5_00517 330214.NIDE4022 1.9e-71 275.0 Nitrospirae fdx GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006790,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016043,GO:0016226,GO:0016491,GO:0022607,GO:0022900,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051540,GO:0055114,GO:0071840 ko:K04755 ko00000 Bacteria 3J1AM@40117,COG0633@1,COG0633@2 NA|NA|NA C 2Fe-2S iron-sulfur cluster binding domain MAG.T1.5_00518 330214.NIDE4021 2.7e-107 394.8 Bacteria poxF Bacteria COG1018@1,COG1018@2 NA|NA|NA C nitric oxide dioxygenase activity MAG.T1.5_00519 330214.NIDE4019 2.1e-247 861.3 Nitrospirae gltX GO:0003674,GO:0003824,GO:0004812,GO:0004818,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006424,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.17,6.1.1.24 ko:K01885,ko:K09698 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R03651,R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 iEC042_1314.EC042_2616,iIT341.HP0476 Bacteria 3J0CJ@40117,COG0008@1,COG0008@2 NA|NA|NA J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) MAG.T1.5_00522 338966.Ppro_1126 1e-29 137.9 Deltaproteobacteria Bacteria 1QV9T@1224,2X7S1@28221,43CGV@68525,COG4974@1,COG4974@2 NA|NA|NA L Belongs to the 'phage' integrase family MAG.T1.5_00524 330214.NIDE0317 1.1e-64 253.1 Bacteria mug GO:0000700,GO:0003674,GO:0003824,GO:0004844,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008263,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360 3.2.2.28,6.3.3.2 ko:K01934,ko:K03649 ko00670,ko01100,ko03410,map00670,map01100,map03410 R02301 RC00183 ko00000,ko00001,ko01000,ko03400 Bacteria COG3663@1,COG3663@2 NA|NA|NA L G/U mismatch-specific uracil-DNA glycosylase activity MAG.T1.5_00526 330214.NIDE0319 1.6e-83 315.5 Nitrospirae nudF 3.6.1.13 ko:K01515 ko00230,map00230 R01054 RC00002 ko00000,ko00001,ko01000 iHN637.CLJU_RS05505,iSB619.SA_RS07540,iYO844.BSU23610 Bacteria 3J0TN@40117,COG0494@1,COG0494@2 NA|NA|NA L NUDIX domain MAG.T1.5_00527 330214.NIDE0320 1.3e-175 622.5 Nitrospirae gcvT 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 Bacteria 3J11R@40117,COG0404@1,COG0404@2 NA|NA|NA H Aminomethyltransferase folate-binding domain MAG.T1.5_00528 330214.NIDE0321 3e-52 211.1 Bacteria fkpA 5.2.1.8 ko:K01802,ko:K03772 ko00000,ko01000,ko03110 Bacteria COG0545@1,COG0545@2 NA|NA|NA O Peptidyl-prolyl cis-trans isomerase MAG.T1.5_00529 330214.NIDE0322 7.2e-180 636.7 Bacteria GO:0008150,GO:0040007 Bacteria COG4398@1,COG4398@2 NA|NA|NA E FIST C domain MAG.T1.5_00531 330214.NIDE0324 1.6e-185 655.6 Bacteria dmpA 3.4.11.19 ko:K01266 ko00000,ko01000,ko01002 Bacteria COG3191@1,COG3191@2 NA|NA|NA EQ aminopeptidase activity MAG.T1.5_00532 330214.NIDE0325 1.4e-251 875.2 Nitrospirae ko:K07576 ko00000 Bacteria 3J0FD@40117,COG1236@1,COG1236@2 NA|NA|NA J Beta-Casp domain MAG.T1.5_00533 330214.NIDE0326 2.3e-140 505.0 Nitrospirae 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 Bacteria 3J169@40117,COG1611@1,COG1611@2 NA|NA|NA S Possible lysine decarboxylase MAG.T1.5_00536 330214.NIDE0329 5.8e-62 243.8 Bacteria Bacteria COG0454@1,COG0456@2 NA|NA|NA K acetyltransferase MAG.T1.5_00537 330214.NIDE0330 3.1e-102 377.9 Nitrospirae Bacteria 3J0R2@40117,COG2928@1,COG2928@2 NA|NA|NA S Protein of unknown function (DUF502) MAG.T1.5_00538 330214.NIDE0331 1.4e-42 179.1 Bacteria ko:K09791 ko00000 Bacteria COG2835@1,COG2835@2 NA|NA|NA EG tetraacyldisaccharide 4'-kinase activity MAG.T1.5_00543 330214.NIDE0618 2.7e-65 254.6 Bacteria Bacteria COG3431@1,COG3431@2 NA|NA|NA MAG.T1.5_00544 643473.KB235931_gene4687 2e-91 342.8 Nostocales pstS GO:0003674,GO:0005488,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015698,GO:0042301,GO:0043167,GO:0043168,GO:0051179,GO:0051234 ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 ko00000,ko00001,ko00002,ko02000 3.A.1.7 Bacteria 1FZZ0@1117,1HIWF@1161,COG0226@1,COG0226@2 NA|NA|NA P Phosphate ABC transporter substrate-binding protein, PhoT family MAG.T1.5_00545 856793.MICA_622 4.5e-50 204.1 unclassified Alphaproteobacteria arsC 1.20.4.1 ko:K03741,ko:K03892 ko00000,ko01000,ko03000 Bacteria 1MWYQ@1224,2TU1U@28211,4BQM3@82117,COG0394@1,COG0394@2 NA|NA|NA T Low molecular weight phosphatase family MAG.T1.5_00546 856793.MICA_623 8.5e-44 183.3 unclassified Alphaproteobacteria cadI GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0050896 4.4.1.5 ko:K01759 ko00620,map00620 R02530 RC00004,RC00740 ko00000,ko00001,ko01000 Bacteria 1RHIV@1224,2TR4K@28211,4BSC6@82117,COG0346@1,COG0346@2 NA|NA|NA E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily MAG.T1.5_00548 330214.NIDE3708 1.3e-140 506.1 Nitrospirae arsB GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015104,GO:0015105,GO:0015291,GO:0015297,GO:0015318,GO:0015698,GO:0015699,GO:0015700,GO:0016020,GO:0022804,GO:0022857,GO:0034220,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656 ko:K03325 ko00000,ko02000 2.A.59 Bacteria 3J0XN@40117,COG0798@1,COG0798@2 NA|NA|NA P Sodium Bile acid symporter family MAG.T1.5_00549 330214.NIDE3710 1.2e-25 122.5 Nitrospirae arsR ko:K03892,ko:K21903 ko00000,ko03000 Bacteria 3J1BW@40117,COG0640@1,COG0640@2 NA|NA|NA K helix_turn_helix, Arsenical Resistance Operon Repressor MAG.T1.5_00550 330214.NIDE0342 2.4e-290 1004.6 Nitrospirae 2.3.2.13 ko:K22452 ko00000,ko01000 Bacteria 3J150@40117,COG1305@1,COG1305@2 NA|NA|NA E Transglutaminase/protease-like homologues MAG.T1.5_00551 330214.NIDE0343 1.2e-139 503.1 Bacteria Bacteria COG1721@1,COG1721@2 NA|NA|NA E protein (some members contain a von Willebrand factor type A (vWA) domain MAG.T1.5_00552 330214.NIDE0344 5.5e-149 533.9 Nitrospirae ko:K03924 ko00000,ko01000 Bacteria 3J0WQ@40117,COG0714@1,COG0714@2 NA|NA|NA S ATPase family associated with various cellular activities (AAA) MAG.T1.5_00554 330214.NIDE0346 2e-130 472.2 Bacteria phuW Bacteria COG3016@1,COG3016@2 NA|NA|NA S Haem-binding uptake, Tiki superfamily, ChaN MAG.T1.5_00555 330214.NIDE0347 1.4e-102 379.4 Bacteria yehQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 Bacteria COG4715@1,COG4715@2 NA|NA|NA S zinc ion binding MAG.T1.5_00557 330214.NIDE0349 4.2e-89 334.7 Bacteria tesA GO:0003674,GO:0003824,GO:0004620,GO:0004622,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016289,GO:0016290,GO:0016298,GO:0016787,GO:0016788,GO:0016790,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0047617,GO:0052689,GO:0071704,GO:0140096,GO:1901564 3.1.1.5 ko:K10804 ko01040,map01040 ko00000,ko00001,ko01000,ko01004 iECED1_1282.ECED1_0521,iLF82_1304.LF82_2242,iNRG857_1313.NRG857_02365 Bacteria COG2755@1,COG2755@2 NA|NA|NA E lipolytic protein G-D-S-L family MAG.T1.5_00558 330214.NIDE0350 1.3e-101 375.9 Bacteria ko:K02003 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria COG1136@1,COG1136@2 NA|NA|NA V lipoprotein transporter activity MAG.T1.5_00559 330214.NIDE0351 0.0 1370.9 Bacteria MA20_43810 ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria COG3127@1,COG3127@2 NA|NA|NA Q FtsX-like permease family MAG.T1.5_00560 330214.NIDE0352 0.0 1413.3 Nitrospirae pepN GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.4.11.2 ko:K01256,ko:K08776 ko00480,ko01100,map00480,map01100 R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 Bacteria 3J0Y4@40117,COG0308@1,COG0308@2 NA|NA|NA E Peptidase family M1 domain MAG.T1.5_00561 330214.NIDE0353 4e-106 391.0 Bacteria rpiA GO:0003674,GO:0003824,GO:0004751,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 2.7.1.12,2.7.1.15,5.3.1.6 ko:K00851,ko:K00852,ko:K01807 ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167,M00580 R01051,R01056,R01737,R02750 RC00002,RC00017,RC00434 ko00000,ko00001,ko00002,ko01000 Bacteria COG0120@1,COG0120@2 NA|NA|NA G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate MAG.T1.5_00562 330214.NIDE0354 9.7e-176 622.9 Nitrospirae glk 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 3J13D@40117,COG0837@1,COG0837@2 NA|NA|NA F Glucokinase MAG.T1.5_00563 330214.NIDE0355 1.1e-93 349.7 Nitrospirae pgl 3.1.1.31 ko:K01057 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R02035 RC00537 ko00000,ko00001,ko00002,ko01000 Bacteria 3J18W@40117,COG0363@1,COG0363@2 NA|NA|NA G Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase MAG.T1.5_00564 330214.NIDE0356 2.9e-267 927.5 Bacteria tal 2.2.1.2,5.3.1.9 ko:K01810,ko:K13810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00004,M00007,M00114 R01827,R02739,R02740,R03321 RC00376,RC00439,RC00563,RC00604 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria COG0166@1,COG0166@2 NA|NA|NA G Belongs to the GPI family MAG.T1.5_00565 330214.NIDE0357 1.3e-172 612.5 Nitrospirae Bacteria 3J19Y@40117,COG3034@1,COG3034@2 NA|NA|NA S L,D-transpeptidase catalytic domain MAG.T1.5_00566 1128912.GMES_4486 1.1e-07 61.6 Alteromonadaceae rpmH GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02914 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1NGGS@1224,1SGDJ@1236,4690G@72275,COG0230@1,COG0230@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL34 family MAG.T1.5_00567 330214.NIDE0359 1.7e-29 134.8 Bacteria rnpA GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031123,GO:0031404,GO:0031974,GO:0031981,GO:0032991,GO:0033204,GO:0034414,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042301,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043168,GO:0043170,GO:0043199,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043628,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901681,GO:1902494,GO:1902555,GO:1905267,GO:1905348,GO:1990904 3.1.26.5 ko:K03536,ko:K08998 ko00000,ko01000,ko03016 Bacteria COG0594@1,COG0594@2 NA|NA|NA J ribonuclease P activity MAG.T1.5_00568 1127695.HMPREF9163_01252 5.6e-21 106.7 Negativicutes yidD ko:K03217,ko:K08998 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 Bacteria 1VEIG@1239,4H5K3@909932,COG0759@1,COG0759@2 NA|NA|NA S Could be involved in insertion of integral membrane proteins into the membrane MAG.T1.5_00569 330214.NIDE0360 2.9e-275 954.1 Nitrospirae yidC GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0031224,GO:0031226,GO:0032940,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051205,GO:0051234,GO:0051259,GO:0051260,GO:0051641,GO:0061024,GO:0065003,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150 ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 Bacteria 3J0GD@40117,COG0706@1,COG0706@2 NA|NA|NA U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins MAG.T1.5_00570 330214.NIDE0361 3e-185 654.8 Nitrospirae mnmE ko:K03650 R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 Bacteria 3J0JZ@40117,COG0486@1,COG0486@2 NA|NA|NA S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 MAG.T1.5_00571 330214.NIDE0362 1.8e-307 1061.2 Nitrospirae gidA GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 ko:K03495 R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 Bacteria 3J0E9@40117,COG0445@1,COG0445@2 NA|NA|NA D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 MAG.T1.5_00572 330214.NIDE0363 3.7e-74 284.6 Nitrospirae rsmG 2.1.1.170 ko:K03501 ko00000,ko01000,ko03009,ko03036 Bacteria 3J18F@40117,COG0357@1,COG0357@2 NA|NA|NA J Specifically methylates the N7 position of a guanine in 16S rRNA MAG.T1.5_00573 330214.NIDE0364 8.7e-120 436.4 Nitrospirae parA ko:K03496 ko00000,ko03036,ko04812 Bacteria 3J0H4@40117,COG1192@1,COG1192@2 NA|NA|NA D Cellulose biosynthesis protein BcsQ MAG.T1.5_00574 330214.NIDE0365 1.7e-127 462.2 Nitrospirae parB GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005694,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0060187,GO:0071944 ko:K03497 ko00000,ko03000,ko03036,ko04812 Bacteria 3J0K9@40117,COG1475@1,COG1475@2 NA|NA|NA K ParB-like nuclease domain MAG.T1.5_00575 330214.NIDE0366 1.5e-75 288.9 Nitrospirae Bacteria 3J1F5@40117,COG1664@1,COG1664@2 NA|NA|NA M Polymer-forming cytoskeletal MAG.T1.5_00576 330214.NIDE0367 4.5e-66 257.3 Bacteria Bacteria COG1664@1,COG1664@2 NA|NA|NA M Polymer-forming cytoskeletal MAG.T1.5_00577 330214.NIDE0368 1.7e-172 612.1 Nitrospirae mnmA 2.8.1.13 ko:K00566 ko04122,map04122 R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 Bacteria 3J0KT@40117,COG0482@1,COG0482@2 NA|NA|NA J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 MAG.T1.5_00578 330214.NIDE0369 1.4e-79 302.4 Nitrospirae atpH ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 Bacteria 3J1BY@40117,COG0712@1,COG0712@2 NA|NA|NA C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation MAG.T1.5_00579 330214.NIDE0370 3.2e-278 963.8 Nitrospirae atpA GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016469,GO:0030312,GO:0032991,GO:0040007,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045259,GO:0045260,GO:0071944,GO:0098796,GO:0098797 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 iSB619.SA_RS10975 Bacteria 3J0CZ@40117,COG0056@1,COG0056@2 NA|NA|NA C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit MAG.T1.5_00580 330214.NIDE0371 1.9e-153 548.5 Nitrospirae atpG GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 iLJ478.TM1611,iSSON_1240.SSON_3886,iYL1228.KPN_04138 Bacteria 3J0J8@40117,COG0224@1,COG0224@2 NA|NA|NA C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex MAG.T1.5_00581 330214.NIDE0372 1.3e-268 931.8 Nitrospirae atpD GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 e_coli_core.b3732,iAF1260.b3732,iAPECO1_1312.APECO1_2729,iB21_1397.B21_03560,iBWG_1329.BWG_3423,iE2348C_1286.E2348C_4042,iEC042_1314.EC042_4119,iEC55989_1330.EC55989_4207,iECABU_c1320.ECABU_c42160,iECBD_1354.ECBD_4300,iECB_1328.ECB_03616,iECDH10B_1368.ECDH10B_3919,iECDH1ME8569_1439.ECDH1ME8569_3620,iECD_1391.ECD_03616,iECED1_1282.ECED1_4422,iECH74115_1262.ECH74115_5168,iECIAI1_1343.ECIAI1_3916,iECIAI39_1322.ECIAI39_4336,iECNA114_1301.ECNA114_3881,iECO103_1326.ECO103_4426,iECO111_1330.ECO111_4566,iECO26_1355.ECO26_4846,iECOK1_1307.ECOK1_4181,iECP_1309.ECP_3931,iECS88_1305.ECS88_4154,iECSE_1348.ECSE_4022,iECSF_1327.ECSF_3580,iECSP_1301.ECSP_4782,iECUMN_1333.ECUMN_4262,iECW_1372.ECW_m4035,iECs_1301.ECs4674,iEKO11_1354.EKO11_4613,iETEC_1333.ETEC_4023,iEcDH1_1363.EcDH1_4235,iEcE24377_1341.EcE24377A_4247,iEcSMS35_1347.EcSMS35_4100,iEcolC_1368.EcolC_4262,iG2583_1286.G2583_4528,iJO1366.b3732,iJR904.b3732,iLF82_1304.LF82_0194,iNRG857_1313.NRG857_18585,iPC815.YPO4121,iSFV_1184.SFV_3758,iSF_1195.SF3812,iSFxv_1172.SFxv_4154,iSSON_1240.SSON_3887,iS_1188.S3956,iSbBS512_1146.SbBS512_E4189,iUMN146_1321.UM146_18850,iUMNK88_1353.UMNK88_4544,iUTI89_1310.UTI89_C4285,iWFL_1372.ECW_m4035,iY75_1357.Y75_RS18410,iZ_1308.Z5230,ic_1306.c4658 Bacteria 3J0BN@40117,COG0055@1,COG0055@2 NA|NA|NA C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits MAG.T1.5_00582 330214.NIDE0373 1.9e-66 258.5 Nitrospirae atpC GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 iHN637.CLJU_RS01195,iJN746.PP_5412,iSbBS512_1146.SbBS512_E4190 Bacteria 3J0SS@40117,COG0355@1,COG0355@2 NA|NA|NA C Produces ATP from ADP in the presence of a proton gradient across the membrane MAG.T1.5_00584 330214.NIDE0376 1.8e-100 372.5 Nitrospirae rluD GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.23 ko:K06180 ko00000,ko01000,ko03009 Bacteria 3J0HF@40117,COG0564@1,COG0564@2 NA|NA|NA J Responsible for synthesis of pseudouridine from uracil MAG.T1.5_00586 330214.NIDE0379 8.7e-158 563.1 Nitrospirae rluD GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.23 ko:K06180 ko00000,ko01000,ko03009 Bacteria 3J0HF@40117,COG0564@1,COG0564@2 NA|NA|NA J Responsible for synthesis of pseudouridine from uracil MAG.T1.5_00589 330214.NIDE0382 5.4e-69 266.9 Bacteria Bacteria COG0454@1,COG0456@2 NA|NA|NA K acetyltransferase MAG.T1.5_00590 330214.NIDE0383 1.6e-130 472.2 Nitrospirae ko:K09816,ko:K09819 ko02010,map02010 M00242,M00243 ko00000,ko00001,ko00002,ko02000 3.A.1.15,3.A.1.15.3,3.A.1.15.5 Bacteria 3J1EQ@40117,COG1108@1,COG1108@2 NA|NA|NA P ABC 3 transport family MAG.T1.5_00591 330214.NIDE0384 3e-135 488.0 Nitrospirae znuC 3.6.3.34 ko:K02013,ko:K09817,ko:K09820 ko02010,map02010 M00240,M00242,M00243 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14,3.A.1.15,3.A.1.15.3,3.A.1.15.5 Bacteria 3J15M@40117,COG1121@1,COG1121@2 NA|NA|NA P AAA domain, putative AbiEii toxin, Type IV TA system MAG.T1.5_00592 330214.NIDE0385 3.7e-136 491.1 Nitrospirae ko:K09815,ko:K09818 ko02010,map02010 M00242,M00243 ko00000,ko00001,ko00002,ko02000 3.A.1.15,3.A.1.15.3,3.A.1.15.5 Bacteria 3J1E3@40117,COG0803@1,COG0803@2 NA|NA|NA P Zinc-uptake complex component A periplasmic MAG.T1.5_00593 330214.NIDE0386 1.1e-175 622.9 Nitrospirae anmK GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0044237 2.7.1.170,4.2.1.126 ko:K07106,ko:K09001 ko00520,ko01100,map00520,map01100 R08555 RC00397,RC00746 ko00000,ko00001,ko01000 iECABU_c1320.ECABU_c18930,iECED1_1282.ECED1_1841,ic_1306.c2032 Bacteria 3J126@40117,COG2377@1,COG2377@2 NA|NA|NA F Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling MAG.T1.5_00595 330214.NIDE0388 4.2e-68 264.2 Bacteria Bacteria COG1729@1,COG1729@2 NA|NA|NA S protein trimerization MAG.T1.5_00596 330214.NIDE0389 2.4e-121 441.8 Bacteria Bacteria COG4677@1,COG4677@2 NA|NA|NA G pectinesterase activity MAG.T1.5_00597 330214.NIDE0390 9.9e-145 519.6 Nitrospirae Bacteria 3J17A@40117,COG2199@1,COG3706@2 NA|NA|NA T diguanylate cyclase MAG.T1.5_00599 330214.NIDE0393 1.1e-101 376.3 Nitrospirae Bacteria 3J19T@40117,COG0741@1,COG0741@2 NA|NA|NA M Transglycosylase SLT domain MAG.T1.5_00601 330214.NIDE0395 5.3e-154 550.4 Nitrospirae fmt GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 R03940 RC00026,RC00165 ko00000,ko00001,ko01000 Bacteria 3J0GW@40117,COG0223@1,COG0223@2 NA|NA|NA J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus MAG.T1.5_00602 330214.NIDE0396 3.3e-205 721.1 Nitrospirae sun GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.176 ko:K03500 ko00000,ko01000,ko03009 Bacteria 3J136@40117,COG0144@1,COG0144@2,COG0781@1,COG0781@2 NA|NA|NA J 16S rRNA methyltransferase RsmB/F MAG.T1.5_00603 330214.NIDE0397 1.5e-108 399.1 Nitrospirae rpe 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0IZ@40117,COG0036@1,COG0036@2 NA|NA|NA G Ribulose-phosphate 3 epimerase family MAG.T1.5_00604 330214.NIDE0398 5.4e-268 929.9 Nitrospirae pheS GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 3J0SW@40117,COG0016@1,COG0016@2 NA|NA|NA J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type MAG.T1.5_00605 330214.NIDE0399 1.4e-298 1031.6 Nitrospirae pheT 6.1.1.20 ko:K01889,ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 3J0U7@40117,COG0072@1,COG0072@2 NA|NA|NA J B3/4 domain MAG.T1.5_00606 330214.NIDE0400 2.6e-56 224.6 Nitrospirae rplT GO:0000027,GO:0000900,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0060255,GO:0065003,GO:0065007,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090079,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2000113,GO:2001141 ko:K02887 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0SF@40117,COG0292@1,COG0292@2 NA|NA|NA J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit MAG.T1.5_00607 330214.NIDE0401 6.9e-24 115.9 Nitrospirae rpmI GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 ko:K02916 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J1F4@40117,COG0291@1,COG0291@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL35 family MAG.T1.5_00608 330214.NIDE0402 2.7e-49 201.1 Nitrospirae infC GO:0000049,GO:0001731,GO:0002181,GO:0002183,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006417,GO:0006446,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016020,GO:0016043,GO:0019222,GO:0019538,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032268,GO:0032270,GO:0032790,GO:0032984,GO:0032988,GO:0032991,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043254,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045727,GO:0045948,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065003,GO:0065007,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901193,GO:1901195,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:1904688,GO:1904690,GO:1990856,GO:1990904,GO:2000112,GO:2000765,GO:2000767 ko:K02520 ko00000,ko03012,ko03029 Bacteria 3J0T0@40117,COG0290@1,COG0290@2 NA|NA|NA J Translation initiation factor IF-3, C-terminal domain MAG.T1.5_00609 330214.NIDE0403 0.0 1226.8 Nitrospirae thrS GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 3J0F4@40117,COG0441@1,COG0441@2 NA|NA|NA J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) MAG.T1.5_00611 330214.NIDE0404 1.3e-36 158.7 Nitrospirae hupB ko:K03530,ko:K04764 ko00000,ko03032,ko03036,ko03400 Bacteria 3J0V6@40117,COG0776@1,COG0776@2 NA|NA|NA L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions MAG.T1.5_00612 330214.NIDE0405 3.8e-78 297.7 Bacteria fis GO:0000018,GO:0000229,GO:0000785,GO:0000786,GO:0000787,GO:0000789,GO:0000976,GO:0000984,GO:0000985,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008301,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016032,GO:0016070,GO:0018130,GO:0019042,GO:0019045,GO:0019046,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031421,GO:0032359,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0042803,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044374,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044427,GO:0044444,GO:0044446,GO:0044464,GO:0044815,GO:0045892,GO:0045893,GO:0045911,GO:0045934,GO:0045935,GO:0046483,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051704,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 ko:K03557,ko:K07712 ko02020,ko05111,map02020,map05111 M00497 ko00000,ko00001,ko00002,ko02022,ko03000,ko03036,ko03400 Bacteria COG2901@1,COG2901@2 NA|NA|NA K sequence-specific DNA binding MAG.T1.5_00613 330214.NIDE0406 5.8e-66 256.9 Bacteria iscR 2.8.1.7 ko:K04487,ko:K13643 ko00730,ko01100,ko04122,map00730,map01100,map04122 R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03000,ko03016,ko03029 Bacteria COG1959@1,COG1959@2 NA|NA|NA K 2 iron, 2 sulfur cluster binding MAG.T1.5_00614 330214.NIDE0407 0.0 1496.9 Nitrospirae cysI 1.7.1.15,1.7.7.1,1.8.1.2,1.8.7.1 ko:K00362,ko:K00366,ko:K00381,ko:K00392 ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120 M00176,M00530,M00531 R00787,R00790,R00858,R00859,R03600 RC00065,RC00176 ko00000,ko00001,ko00002,ko01000 Bacteria 3J11D@40117,COG0155@1,COG0155@2,COG0425@1,COG0425@2 NA|NA|NA C Nitrite and sulphite reductase 4Fe-4S domain MAG.T1.5_00615 330214.NIDE0408 1.3e-120 439.1 Bacteria cysH GO:0003674,GO:0003824,GO:0004604,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016667,GO:0016671,GO:0044424,GO:0044464,GO:0055114 1.8.4.10,1.8.4.8,2.7.1.25 ko:K00390,ko:K00860 ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120 M00176 R00509,R02021,R04928 RC00002,RC00007,RC00078,RC02862 ko00000,ko00001,ko00002,ko01000 Bacteria COG0175@1,COG0175@2 NA|NA|NA EH sulfate reduction MAG.T1.5_00616 330214.NIDE0409 1.6e-170 605.5 Nitrospirae Bacteria 3J17P@40117,COG0547@1,COG0547@2 NA|NA|NA E Glycosyl transferase family, a/b domain MAG.T1.5_00617 330214.NIDE0410 5.5e-152 543.5 Bacteria cysD 1.8.4.10,1.8.4.8,2.7.7.4 ko:K00390,ko:K00957 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R02021,R04929 RC00007,RC02809,RC02862,RC02889 ko00000,ko00001,ko00002,ko01000 Bacteria COG0175@1,COG0175@2 NA|NA|NA EH sulfate reduction MAG.T1.5_00618 330214.NIDE0411 0.0 1159.8 Bacteria cysC 2.7.1.25,2.7.7.4 ko:K00860,ko:K00955,ko:K00956 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00509,R00529,R04928,R04929 RC00002,RC00078,RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 Bacteria COG0529@1,COG0529@2,COG2895@1,COG2895@2 NA|NA|NA P sulfate adenylyltransferase (ATP) activity MAG.T1.5_00619 330214.NIDE0412 1.5e-164 585.5 Bacteria ko:K03593 ko00000,ko03029,ko03036 Bacteria COG0489@1,COG0489@2 NA|NA|NA D protein tyrosine kinase activity MAG.T1.5_00620 330214.NIDE0413 1.5e-130 472.2 Bacteria bchB Bacteria 2DQ3Q@1,334KX@2 NA|NA|NA S Proto-chlorophyllide reductase 57 kd subunit MAG.T1.5_00621 330214.NIDE0414 2e-91 342.4 Bacteria Bacteria COG4244@1,COG4244@2 NA|NA|NA E Membrane MAG.T1.5_00622 330214.NIDE0415 9.8e-127 459.5 Nitrospirae yebC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 Bacteria 3J0DM@40117,COG0217@1,COG0217@2 NA|NA|NA K Transcriptional regulator MAG.T1.5_00623 330214.NIDE0416 3.5e-90 337.8 Nitrospirae ruvA GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 ko:K03550 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 3J0VA@40117,COG0632@1,COG0632@2 NA|NA|NA L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB MAG.T1.5_00625 330214.NIDE0418 7.6e-178 629.8 Nitrospirae ruvB GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 3.6.4.12 ko:K03551 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 3J0AU@40117,COG2255@1,COG2255@2 NA|NA|NA L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing MAG.T1.5_00626 330214.NIDE0419 5.1e-193 680.2 Nitrospirae pheA GO:0003674,GO:0003824,GO:0004106,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 1.3.1.12,2.3.1.79,4.2.1.51,4.2.1.91,5.4.99.5 ko:K00661,ko:K01713,ko:K04092,ko:K04093,ko:K04516,ko:K04518,ko:K14170,ko:K14187 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715,R01728 RC00125,RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 iECNA114_1301.ECNA114_2667 Bacteria 3J0A9@40117,COG0077@1,COG0077@2,COG1605@1,COG1605@2 NA|NA|NA E Chorismate mutase type II MAG.T1.5_00628 330214.NIDE0420 7.1e-187 659.8 Nitrospirae hisC 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 3J0XY@40117,COG0079@1,COG0079@2 NA|NA|NA E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily MAG.T1.5_00629 330214.NIDE0421 1.6e-185 655.2 Nitrospirae aroF 2.5.1.54 ko:K03856 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0A5@40117,COG2876@1,COG2876@2 NA|NA|NA E NeuB family MAG.T1.5_00630 330214.NIDE0422 1.8e-151 542.0 Nitrospirae aroA GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009095,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019438,GO:0019752,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0047794,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.3.1.12,1.3.1.43,2.5.1.19 ko:K00210,ko:K00220,ko:K00800,ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00022,M00025,M00040 R00732,R01728,R03460 RC00125,RC00350 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0SQ@40117,COG0287@1,COG0287@2 NA|NA|NA C Prephenate dehydrogenase MAG.T1.5_00631 330214.NIDE0423 1.4e-216 758.8 Nitrospirae aroA GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 1.3.1.12,1.3.1.43,2.5.1.19 ko:K00210,ko:K00220,ko:K00800 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00022,M00025,M00040 R00732,R01728,R03460 RC00125,RC00350 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0BZ@40117,COG0128@1,COG0128@2 NA|NA|NA E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate MAG.T1.5_00632 330214.NIDE0424 3.2e-108 397.9 Nitrospirae cmk GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0015939,GO:0015940,GO:0015949,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 1.17.7.4,2.5.1.19,2.7.1.26,2.7.4.25,2.7.7.2,6.3.2.1 ko:K00800,ko:K00945,ko:K02945,ko:K03527,ko:K03977,ko:K11753,ko:K13799 ko00240,ko00400,ko00410,ko00740,ko00770,ko00900,ko01100,ko01110,ko01130,ko01230,ko03010,map00240,map00400,map00410,map00740,map00770,map00900,map01100,map01110,map01130,map01230,map03010 M00022,M00052,M00096,M00119,M00125,M00178 R00158,R00161,R00512,R00549,R01665,R02473,R03460,R05884,R08210 RC00002,RC00017,RC00096,RC00141,RC00350,RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko03009,ko03011 iPC815.YPO1391,iSDY_1059.SDY_2348 Bacteria 3J0MY@40117,COG0283@1,COG0283@2 NA|NA|NA F Belongs to the cytidylate kinase family. Type 1 subfamily MAG.T1.5_00633 330214.NIDE0425 4.5e-118 430.6 Nitrospirae plsC 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 3J16H@40117,COG0204@1,COG0204@2 NA|NA|NA I Phosphate acyltransferases MAG.T1.5_00634 330214.NIDE0426 0.0 1080.1 Nitrospirae rpsA 1.17.7.4 ko:K02945,ko:K03527,ko:K07571 ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010 M00096,M00178 R05884,R08210 RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko03011 Bacteria 3J0CA@40117,COG0539@1,COG0539@2,COG1185@1,COG1185@2 NA|NA|NA J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence MAG.T1.5_00635 330214.NIDE0427 1.9e-153 548.5 Nitrospirae sppA ko:K04773 ko00000,ko01000,ko01002 Bacteria 3J0J0@40117,COG0616@1,COG0616@2 NA|NA|NA OU Peptidase family S49 MAG.T1.5_00636 330214.NIDE0428 1.8e-41 174.9 Nitrospirae ihfB ko:K05788 ko00000,ko03032,ko03036,ko03400 Bacteria 3J19J@40117,COG0776@1,COG0776@2 NA|NA|NA L bacterial (prokaryotic) histone like domain MAG.T1.5_00637 330214.NIDE0429 2.8e-161 574.7 Bacteria Bacteria 2C1IB@1,2ZG3S@2 NA|NA|NA S Proto-chlorophyllide reductase 57 kD subunit MAG.T1.5_00640 330214.NIDE0431 1e-85 323.9 Bacteria Bacteria COG3391@1,COG3391@2 NA|NA|NA CO amine dehydrogenase activity MAG.T1.5_00642 330214.NIDE0434 2.3e-154 551.6 Nitrospirae dacA 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 ko00000,ko00001,ko01000,ko01002,ko01011 Bacteria 3J179@40117,COG1686@1,COG1686@2 NA|NA|NA M Belongs to the peptidase S11 family MAG.T1.5_00644 330214.NIDE0436 6e-143 513.8 Nitrospirae cynR ko:K11921 ko00000,ko03000 Bacteria 3J16P@40117,COG0583@1,COG0583@2 NA|NA|NA K Transcriptional regulator MAG.T1.5_00645 330214.NIDE0437 1.9e-62 245.4 Bacteria glbN ko:K06886 ko00000 Bacteria COG2346@1,COG2346@2 NA|NA|NA O COG2346, Truncated hemoglobins MAG.T1.5_00648 330214.NIDE0440 1.8e-218 765.0 Bacteria gdhA 1.4.1.3,1.4.1.4 ko:K00261,ko:K00262 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria COG0334@1,COG0334@2 NA|NA|NA E glutamate dehydrogenase [NAD(P)+] activity MAG.T1.5_00649 330214.NIDE0441 7.8e-93 347.1 Bacteria lipB GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0016874,GO:0016879,GO:0016979,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019222,GO:0019538,GO:0019752,GO:0032787,GO:0033819,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048519,GO:0050789,GO:0051186,GO:0051188,GO:0051604,GO:0060255,GO:0065007,GO:0071704,GO:0072330,GO:0140096,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.3.1.181,2.8.1.8 ko:K03644,ko:K03801 ko00785,ko01100,map00785,map01100 R07766,R07767,R07768,R07769 RC00039,RC00992,RC01978,RC02867 ko00000,ko00001,ko01000 iECSF_1327.ECSF_0569,iSFV_1184.SFV_0696,iSFxv_1172.SFxv_0718 Bacteria COG0321@1,COG0321@2 NA|NA|NA H lipoyl(octanoyl) transferase activity MAG.T1.5_00650 330214.NIDE0442 2.3e-161 575.1 Bacteria 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 Bacteria COG0265@1,COG0265@2 NA|NA|NA O serine-type endopeptidase activity MAG.T1.5_00651 330214.NIDE0443 7.2e-191 673.3 Nitrospirae rpoD ko:K03086,ko:K03091 ko00000,ko03021 Bacteria 3J0E4@40117,COG0568@1,COG0568@2 NA|NA|NA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released MAG.T1.5_00652 330214.NIDE0444 4e-156 557.4 Nitrospirae trmI GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016426,GO:0016429,GO:0016740,GO:0016741,GO:0030488,GO:0031515,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.219,2.1.1.220 ko:K07442 ko00000,ko01000,ko03016 Bacteria 3J0PT@40117,COG2519@1,COG2519@2 NA|NA|NA J Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA MAG.T1.5_00653 1123252.ATZF01000001_gene1093 1.1e-53 216.9 Thermoactinomycetaceae Bacteria 1TSCT@1239,27CWA@186824,4HD4Z@91061,COG1028@1,COG1028@2 NA|NA|NA IQ Enoyl-(Acyl carrier protein) reductase MAG.T1.5_00654 330214.NIDE0446 5.7e-147 526.9 Nitrospirae aroE GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0SM@40117,COG0169@1,COG0169@2 NA|NA|NA E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) MAG.T1.5_00655 330214.NIDE0447 3.4e-78 297.7 Nitrospirae aroK GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71,4.2.3.4 ko:K00891,ko:K13829,ko:K15546 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412,R03083 RC00002,RC00078,RC00847 ko00000,ko00001,ko00002,ko01000,ko03000 iAPECO1_1312.APECO1_1620,iECOK1_1307.ECOK1_0367,iECS88_1305.ECS88_0383,iUMN146_1321.UM146_15425,iUTI89_1310.UTI89_C0407,iYL1228.KPN_00332 Bacteria 3J0R8@40117,COG0703@1,COG0703@2 NA|NA|NA F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate MAG.T1.5_00662 203122.Sde_0436 6e-15 88.2 Proteobacteria Bacteria 1N7ZA@1224,2EDJI@1,337FD@2 NA|NA|NA MAG.T1.5_00665 330214.NIDE0457 4.4e-39 166.8 Bacteria relB1 ko:K07473 ko00000,ko02048 Bacteria COG3077@1,COG3077@2 NA|NA|NA L bacterial-type proximal promoter sequence-specific DNA binding MAG.T1.5_00667 330214.NIDE0460 1.8e-101 375.6 Nitrospirae pal ko:K03640 ko00000,ko02000 2.C.1.2 Bacteria 3J17Q@40117,COG2885@1,COG2885@2 NA|NA|NA M Belongs to the ompA family MAG.T1.5_00669 330214.NIDE0462 1.9e-253 881.3 Bacteria Bacteria COG4949@1,COG4949@2 NA|NA|NA S Protein of unknown function (DUF3422) MAG.T1.5_00675 330214.NIDE0467 2.1e-86 325.9 Bacteria ko:K03832 ko00000,ko02000 2.C.1.1 Bacteria COG0810@1,COG0810@2 NA|NA|NA M energy transducer activity MAG.T1.5_00676 330214.NIDE0468 3e-276 957.2 Nitrospirae zwf GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 3J0XD@40117,COG0364@1,COG0364@2 NA|NA|NA G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone MAG.T1.5_00677 330214.NIDE0469 3.4e-81 307.8 Nitrospirae msrA 1.8.4.11 ko:K07304 ko00000,ko01000 Bacteria 3J12A@40117,COG0225@1,COG0225@2 NA|NA|NA C Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine MAG.T1.5_00679 330214.NIDE0471 2.4e-132 478.4 Bacteria ttcA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0016783,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360 2.8.1.15,6.3.4.19 ko:K04075,ko:K14058,ko:K21947 R09597 RC02633,RC02634 ko00000,ko01000,ko03016 Bacteria COG0037@1,COG0037@2 NA|NA|NA D tRNA processing MAG.T1.5_00680 330214.NIDE0473 2.1e-183 648.3 Bacteria Bacteria COG4307@1,COG4307@2 NA|NA|NA T Protein conserved in bacteria MAG.T1.5_00681 330214.NIDE0474 5e-182 643.7 Bacteria ddlB1 6.3.2.4,6.3.5.5 ko:K01921,ko:K01955 ko00240,ko00250,ko00473,ko00550,ko01100,ko01502,map00240,map00250,map00473,map00550,map01100,map01502 M00051 R00256,R00575,R01150,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC00064,RC00141,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000,ko01011 Bacteria COG1181@1,COG1181@2 NA|NA|NA F Belongs to the D-alanine--D-alanine ligase family MAG.T1.5_00684 330214.NIDE0478 5.5e-104 383.6 Nitrospirae gpmA GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031 5.4.2.11 ko:K01834 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 Bacteria 3J118@40117,COG0588@1,COG0588@2 NA|NA|NA G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate MAG.T1.5_00686 330214.NIDE0482 2.5e-99 368.2 Bacteria pilA ko:K02650 ko02020,map02020 ko00000,ko00001,ko02035,ko02044 3.A.15.2 Bacteria COG4969@1,COG4969@2 NA|NA|NA NU cell adhesion MAG.T1.5_00687 330214.NIDE0483 9e-207 726.1 Nitrospirae argD GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 iAF987.Gmet_0204,iHN637.CLJU_RS10560 Bacteria 3J0AB@40117,COG4992@1,COG4992@2 NA|NA|NA E Aminotransferase class-III MAG.T1.5_00688 330214.NIDE0484 3.2e-162 577.8 Nitrospirae argF GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0033554,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0043857,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.11,2.1.3.3,2.1.3.6,2.1.3.9,2.7.2.2 ko:K00611,ko:K00926,ko:K09065,ko:K13043,ko:K13252 ko00220,ko00230,ko00910,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00220,map00230,map00910,map01100,map01110,map01120,map01130,map01200,map01230 M00029,M00844,M00845 R00150,R01395,R01398,R07245,R08937 RC00002,RC00043,RC00096,RC02803,RC02804 ko00000,ko00001,ko00002,ko01000 iAF1260.b0273,iECDH10B_1368.ECDH10B_0261,iECS88_1305.ECS88_4841,iHN637.CLJU_RS12430,iJO1366.b0273,iJR904.b0273,iLJ478.TM1097,iY75_1357.Y75_RS01410 Bacteria 3J0G7@40117,COG0078@1,COG0078@2 NA|NA|NA E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline MAG.T1.5_00689 330214.NIDE0485 1.4e-223 781.9 Nitrospirae argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 iJN678.argG,iSB619.SA_RS04675 Bacteria 3J0BU@40117,COG0137@1,COG0137@2 NA|NA|NA E Belongs to the argininosuccinate synthase family. Type 1 subfamily MAG.T1.5_00690 330214.NIDE0486 2.8e-239 834.3 Nitrospirae argH GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0030312,GO:0040007,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 iJN678.argH Bacteria 3J0EN@40117,COG0165@1,COG0165@2 NA|NA|NA E Argininosuccinate lyase C-terminal MAG.T1.5_00692 330214.NIDE0488 1.1e-215 755.7 Nitrospirae lysA GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008836,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.1.129,3.4.16.4,4.1.1.20 ko:K01586,ko:K05366 ko00300,ko00550,ko01100,ko01110,ko01120,ko01130,ko01230,ko01501,map00300,map00550,map01100,map01110,map01120,map01130,map01230,map01501 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000,ko01003,ko01011 GT51 iLJ478.TM1517 Bacteria 3J0CR@40117,COG0019@1,COG0019@2 NA|NA|NA E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine MAG.T1.5_00693 330214.NIDE0489 2.2e-146 525.0 Nitrospirae dapA 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0CF@40117,COG0329@1,COG0329@2 NA|NA|NA E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) MAG.T1.5_00694 330214.NIDE0490 1.3e-137 495.7 Nitrospirae dapB GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.17.1.8 ko:K00215,ko:K03546 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000,ko03400 iIT341.HP0510,iLJ478.TM1520,iSbBS512_1146.SbBS512_E0035 Bacteria 3J0IJ@40117,COG0289@1,COG0289@2 NA|NA|NA E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate MAG.T1.5_00695 330214.NIDE0491 1.8e-19 101.7 Bacteria tmoA GO:0003674,GO:0003824,GO:0004497,GO:0005575,GO:0008150,GO:0008152,GO:0009987,GO:0015049,GO:0015050,GO:0015947,GO:0016491,GO:0016705,GO:0016709,GO:0032991,GO:0043446,GO:0044237,GO:0055114,GO:0071704,GO:1902494 1.14.13.227,1.14.13.236,1.14.13.25,1.14.13.69,2.4.1.1 ko:K00688,ko:K15760,ko:K16157,ko:K16242,ko:K18223,ko:K22353,ko:K22357 ko00361,ko00362,ko00500,ko00623,ko00625,ko00640,ko00680,ko01100,ko01110,ko01120,ko01200,ko01220,ko02026,ko04217,ko04910,ko04922,ko04931,map00361,map00362,map00500,map00623,map00625,map00640,map00680,map01100,map01110,map01120,map01200,map01220,map02026,map04217,map04910,map04922,map04931 M00174,M00538,M00548 R01142,R02111,R02550,R03560,R03562,R03608,R05444,R05666,R10042,R10043,R10702,R11901 RC00046,RC00173,RC00269,RC00490,RC01383,RC03249 ko00000,ko00001,ko00002,ko01000 GT35 Bacteria COG3350@1,COG3350@2 NA|NA|NA T monooxygenase activity MAG.T1.5_00697 330214.NIDE0493 1.5e-112 412.1 Nitrospirae tal GO:0003674,GO:0003824,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016832,GO:0019637,GO:0044237,GO:0071704,GO:1901135 2.2.1.2 ko:K00616 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01827 RC00439,RC00604 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0YY@40117,COG0176@1,COG0176@2 NA|NA|NA F Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway MAG.T1.5_00698 330214.NIDE0494 1.2e-108 399.4 Bacteria udgB GO:0003674,GO:0003824,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033958,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360 3.2.2.27 ko:K21929 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria COG1573@1,COG1573@2 NA|NA|NA L deaminated base DNA N-glycosylase activity MAG.T1.5_00699 330214.NIDE0495 2.1e-170 605.1 Nitrospirae mltD_2 Bacteria 3J0J4@40117,COG0741@1,COG0741@2 NA|NA|NA M Lysin motif MAG.T1.5_00700 330214.NIDE0496 3.2e-181 641.3 Nitrospirae ttuD 2.7.1.165 ko:K11529 ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200 M00346 R08572 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 Bacteria 3J16T@40117,COG2379@1,COG2379@2 NA|NA|NA H MOFRL family MAG.T1.5_00701 330214.NIDE0497 0.0 1153.3 Nitrospirae ppsA2 2.7.1.40,2.7.9.2 ko:K00873,ko:K01007 ko00010,ko00230,ko00620,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map00680,map00720,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050,M00173,M00374 R00199,R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 Bacteria 3J0QY@40117,COG0574@1,COG0574@2,COG3848@1,COG3848@2 NA|NA|NA G PEP-utilising enzyme, mobile domain MAG.T1.5_00702 330214.NIDE0498 1.6e-186 659.1 Nitrospirae rmuC ko:K09760 ko00000 Bacteria 3J15T@40117,COG1322@1,COG1322@2 NA|NA|NA S RmuC family MAG.T1.5_00703 330214.NIDE0499 1.5e-55 222.2 Bacteria XK27_03185 ko:K16785 ko02010,map02010 M00582 ko00000,ko00001,ko00002,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 Bacteria COG4696@1,COG4696@2 NA|NA|NA J Protein conserved in bacteria MAG.T1.5_00705 330214.NIDE0501 2.9e-119 434.9 Nitrospirae panC GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0KR@40117,COG0414@1,COG0414@2 NA|NA|NA H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate MAG.T1.5_00706 330214.NIDE0502 5.5e-82 310.5 Nitrospirae folK 2.7.6.3,4.1.2.25 ko:K00950,ko:K13940 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503,R03504 RC00002,RC00017,RC00721,RC00943 ko00000,ko00001,ko00002,ko01000 iLJ478.TM0041 Bacteria 3J19N@40117,COG0801@1,COG0801@2 NA|NA|NA H 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) MAG.T1.5_00707 330214.NIDE0503 1.2e-219 768.8 Nitrospirae dapL 2.6.1.83 ko:K10206,ko:K14261 ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230 M00527 R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 3J0G2@40117,COG0436@1,COG0436@2 NA|NA|NA E Aminotransferase class I and II MAG.T1.5_00708 330214.NIDE0504 5.6e-137 494.2 Bacteria ko:K13663 ko00000,ko01000 Bacteria COG1835@1,COG1835@2 NA|NA|NA I transferase activity, transferring acyl groups other than amino-acyl groups MAG.T1.5_00710 330214.NIDE0507 5.7e-139 500.4 Nitrospirae wzm ko:K01992,ko:K09690 ko02010,map02010 M00250,M00254 ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.103 Bacteria 3J1DI@40117,COG1682@1,COG1682@2 NA|NA|NA U ABC-2 type transporter MAG.T1.5_00711 330214.NIDE0508 1.3e-206 725.7 Nitrospirae 3.6.3.38 ko:K01990,ko:K09689,ko:K09691 ko02010,map02010 M00249,M00250,M00254 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.101,3.A.1.103 Bacteria 3J142@40117,COG1134@1,COG1134@2 NA|NA|NA GM Evidence 2b Function of strongly homologous gene MAG.T1.5_00714 330214.NIDE0511 5.7e-113 413.7 Bacteria pmtA 2.1.1.17,2.1.1.71 ko:K00570 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00091 R01320,R02056,R03424 RC00003,RC00060,RC00181,RC00496 ko00000,ko00001,ko00002,ko01000 Bacteria COG0500@1,COG2226@2 NA|NA|NA Q methyltransferase MAG.T1.5_00718 330214.NIDE0515 2.3e-73 282.0 Bacteria Bacteria COG0406@1,COG0406@2 NA|NA|NA G alpha-ribazole phosphatase activity MAG.T1.5_00719 330214.NIDE0516 1.8e-123 449.1 Bacteria hcf136 Bacteria COG4447@1,COG4447@2 NA|NA|NA S cellulose binding MAG.T1.5_00720 330214.NIDE0517 8.9e-152 543.5 Nitrospirae attH Bacteria 3J19I@40117,COG5621@1,COG5621@2 NA|NA|NA S Lipocalin-like domain MAG.T1.5_00721 330214.NIDE0518 4.9e-117 427.2 Nitrospirae lonD 3.4.21.53 ko:K01338,ko:K07157 ko04112,map04112 ko00000,ko00001,ko01000,ko01002 Bacteria 3J13Q@40117,COG2802@1,COG2802@2 NA|NA|NA S ATP-dependent protease La (LON) substrate-binding domain MAG.T1.5_00722 330214.NIDE0519 2.6e-164 584.7 Nitrospirae ccmA ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 3J0JF@40117,COG1131@1,COG1131@2 NA|NA|NA V AAA domain, putative AbiEii toxin, Type IV TA system MAG.T1.5_00723 330214.NIDE0520 6.6e-134 483.4 Bacteria ycf38 ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria COG0842@1,COG0842@2 NA|NA|NA V Transport permease protein MAG.T1.5_00724 330214.NIDE0521 3.1e-145 521.2 Bacteria Bacteria COG2912@1,COG2912@2 NA|NA|NA P Transglutaminase-like superfamily MAG.T1.5_00725 330214.NIDE0522 1.4e-125 455.7 Bacteria Bacteria COG1234@1,COG1234@2 NA|NA|NA L tRNA 3'-trailer cleavage MAG.T1.5_00726 330214.NIDE0523 2.6e-66 258.1 Nitrospirae Bacteria 3J14X@40117,COG1846@1,COG1846@2 NA|NA|NA K Winged helix-turn-helix DNA-binding MAG.T1.5_00727 330214.NIDE0524 8.6e-84 316.6 Bacteria 4.4.1.31 ko:K02632 ko00196,map00196 ko00000,ko00001,ko00194,ko01000 Bacteria COG1413@1,COG1413@2 NA|NA|NA C deoxyhypusine monooxygenase activity MAG.T1.5_00728 330214.NIDE0525 8.8e-145 519.6 Nitrospirae ko:K07098 ko00000 Bacteria 3J0SB@40117,COG1408@1,COG1408@2 NA|NA|NA S Calcineurin-like phosphoesterase MAG.T1.5_00730 330214.NIDE0527 2.1e-175 621.7 Bacteria truD GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.27 ko:K06176 ko00000,ko01000,ko03016 Bacteria COG0585@1,COG0585@2 NA|NA|NA J pseudouridine synthase activity MAG.T1.5_00731 330214.NIDE0528 4.9e-200 703.7 Bacteria Bacteria COG1915@1,COG1915@2 NA|NA|NA E PFAM LOR SDH bifunctional enzyme conserved region MAG.T1.5_00732 330214.NIDE0529 2.1e-127 461.8 Bacteria GO:0003674,GO:0003824,GO:0016403,GO:0016787,GO:0016810,GO:0016813 2.6.1.13 ko:K00819 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 R00667 RC00006,RC00062 ko00000,ko00001,ko01000,ko01007 Bacteria COG1834@1,COG1834@2 NA|NA|NA E dimethylargininase activity MAG.T1.5_00734 330214.NIDE0531 2.3e-150 538.5 Nitrospirae gpsA 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 R00842,R00844 RC00029 ko00000,ko00001,ko01000 Bacteria 3J0GP@40117,COG0240@1,COG0240@2 NA|NA|NA I NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus MAG.T1.5_00735 330214.NIDE0532 5.9e-122 443.7 Bacteria cpmA ko:K06898 ko00000 Bacteria COG1691@1,COG1691@2 NA|NA|NA C (AIR) carboxylase MAG.T1.5_00737 330214.NIDE0534 8.4e-189 666.4 Bacteria larC 4.99.1.12 ko:K09121 ko00000,ko01000 Bacteria COG1641@1,COG1641@2 NA|NA|NA H Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes MAG.T1.5_00738 330214.NIDE0535 5.4e-163 580.5 Nitrospirae ko:K07301 ko00000,ko02000 2.A.19.5 Bacteria 3J0V1@40117,COG0530@1,COG0530@2 NA|NA|NA P Sodium/calcium exchanger protein MAG.T1.5_00739 330214.NIDE0536 6.2e-172 610.1 Nitrospirae pdxA 1.1.1.262,1.1.1.408,1.1.1.409 ko:K00097,ko:K22024 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0GF@40117,COG1995@1,COG1995@2 NA|NA|NA C Pyridoxal phosphate biosynthetic protein PdxA MAG.T1.5_00741 330214.NIDE0538 1.9e-120 438.7 Nitrospirae ksgA GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182,2.1.1.184 ko:K00561,ko:K02528 R10716 RC00003,RC03257 br01600,ko00000,ko01000,ko01504,ko03009 Bacteria 3J0R6@40117,COG0030@1,COG0030@2 NA|NA|NA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits MAG.T1.5_00742 330214.NIDE0539 0.0 1391.7 Nitrospirae ftsK GO:0000920,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006950,GO:0006970,GO:0007059,GO:0008094,GO:0008150,GO:0009628,GO:0009651,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0015616,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033676,GO:0042221,GO:0042623,GO:0042802,GO:0043085,GO:0043565,GO:0044093,GO:0044425,GO:0044459,GO:0044464,GO:0045893,GO:0045935,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051301,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0070887,GO:0071236,GO:0071944,GO:0080090,GO:0097159,GO:0140097,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 ko:K03466 ko00000,ko03036 3.A.12 Bacteria 3J0BQ@40117,COG1674@1,COG1674@2 NA|NA|NA D Ftsk_gamma MAG.T1.5_00743 330214.NIDE0540 3.4e-116 424.5 Nitrospirae lolA ko:K03634 ko00000 Bacteria 3J1C6@40117,COG2834@1,COG2834@2 NA|NA|NA M Outer membrane lipoprotein carrier protein LolA MAG.T1.5_00744 330214.NIDE0541 1.3e-129 469.2 Bacteria Bacteria COG3145@1,COG3145@2 NA|NA|NA L oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors MAG.T1.5_00745 330214.NIDE0542 0.0 1315.8 Bacteria 2.7.13.3 ko:K02482 ko00000,ko01000,ko01001,ko02022 Bacteria COG0745@1,COG0745@2,COG3829@1,COG3829@2,COG4191@1,COG4191@2 NA|NA|NA T transcription factor binding MAG.T1.5_00746 330214.NIDE0557 4.6e-82 312.8 Bacteria Bacteria COG0642@1,COG0745@1,COG0745@2,COG2203@1,COG2203@2,COG2205@2 NA|NA|NA T PhoQ Sensor MAG.T1.5_00747 330214.NIDE0544 1.9e-127 462.2 Bacteria ko:K01989 M00247 ko00000,ko00002,ko02000 Bacteria COG2984@1,COG2984@2 NA|NA|NA S ABC transporter substrate binding protein MAG.T1.5_00748 330214.NIDE0545 0.0 1656.0 Bacteria 3.1.3.3 ko:K07315 ko00000,ko01000,ko03021 Bacteria COG0745@1,COG0745@2,COG2202@1,COG2202@2,COG3290@1,COG3290@2 NA|NA|NA T protein histidine kinase activity MAG.T1.5_00749 330214.NIDE0546 2.5e-225 788.5 Bacteria ko:K02014 ko00000,ko02000 1.B.14 Bacteria COG1629@1,COG4771@2 NA|NA|NA P transport MAG.T1.5_00750 330214.NIDE0547 0.0 1211.8 Bacteria ko:K02014 ko00000,ko02000 1.B.14 Bacteria COG1629@1,COG4771@2 NA|NA|NA P transport MAG.T1.5_00755 330214.NIDE0556 9e-227 792.7 Bacteria fadL ko:K06076 ko00000,ko02000 1.B.9 Bacteria COG2067@1,COG2067@2 NA|NA|NA I long-chain fatty acid transporting porin activity MAG.T1.5_00756 330214.NIDE0557 0.0 1511.9 Bacteria Bacteria COG0642@1,COG0745@1,COG0745@2,COG2203@1,COG2203@2,COG2205@2 NA|NA|NA T PhoQ Sensor MAG.T1.5_00757 330214.NIDE0558 2.5e-245 854.7 Bacteria Bacteria COG2010@1,COG2010@2 NA|NA|NA C Cytochrome c MAG.T1.5_00759 330214.NIDE0561 4.2e-272 943.3 Nitrospirae Bacteria 3J10V@40117,COG0535@1,COG0535@2 NA|NA|NA C Iron-sulfur cluster-binding domain MAG.T1.5_00760 330214.NIDE0562 0.0 1314.3 Bacteria usp1 1.6.3.4 ko:K22405 ko00000,ko01000 Bacteria COG0589@1,COG0589@2,COG1592@1,COG1592@2 NA|NA|NA C Rubrerythrin MAG.T1.5_00761 330214.NIDE0563 6.5e-301 1039.3 Nitrospirae Bacteria 3J0WM@40117,COG1032@1,COG1032@2 NA|NA|NA C Elongator protein 3, MiaB family, Radical SAM MAG.T1.5_00762 330214.NIDE0564 7.7e-123 446.4 Nitrospirae ubiE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008425,GO:0008757,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0030580,GO:0032259,GO:0040007,GO:0042180,GO:0042181,GO:0043333,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 iAF1260.b3833,iBWG_1329.BWG_3511,iE2348C_1286.E2348C_4147,iEC042_1314.EC042_4213,iEC55989_1330.EC55989_4310,iECDH10B_1368.ECDH10B_4024,iECDH1ME8569_1439.ECDH1ME8569_3712,iECH74115_1262.ECH74115_5274,iECIAI1_1343.ECIAI1_4028,iECIAI39_1322.ECIAI39_3162,iECO103_1326.ECO103_4330,iECO111_1330.ECO111_4661,iECO26_1355.ECO26_4752,iECSE_1348.ECSE_4121,iECSP_1301.ECSP_4888,iECUMN_1333.ECUMN_4359,iECW_1372.ECW_m4135,iECs_1301.ECs4763,iEKO11_1354.EKO11_4524,iETEC_1333.ETEC_4110,iEcDH1_1363.EcDH1_4146,iEcE24377_1341.EcE24377A_4354,iEcHS_1320.EcHS_A4057,iEcSMS35_1347.EcSMS35_4216,iEcolC_1368.EcolC_4175,iG2583_1286.G2583_4633,iJO1366.b3833,iJR904.b3833,iSBO_1134.SBO_3847,iSDY_1059.SDY_3910,iSFV_1184.SFV_3665,iSF_1195.SF3911,iSFxv_1172.SFxv_4263,iSSON_1240.SSON_4008,iS_1188.S3843,iSbBS512_1146.SbBS512_E4305,iUMNK88_1353.UMNK88_4663,iWFL_1372.ECW_m4135,iY75_1357.Y75_RS17910,iZ_1308.Z5355 Bacteria 3J0S6@40117,COG0500@1,COG2226@2 NA|NA|NA H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) MAG.T1.5_00763 330214.NIDE0565 6.1e-140 503.4 Nitrospirae Bacteria 3J0J9@40117,COG0426@1,COG0426@2 NA|NA|NA C Metallo-beta-lactamase superfamily MAG.T1.5_00765 330214.NIDE0568 0.0 1588.5 Nitrospirae uvrA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1905347,GO:1905348,GO:1990391 ko:K03701 ko03420,map03420 ko00000,ko00001,ko03400 Bacteria 3J0C7@40117,COG0178@1,COG0178@2 NA|NA|NA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate MAG.T1.5_00767 330214.NIDE0571 1.4e-53 215.3 Bacteria ko:K09922 ko00000 Bacteria COG3169@1,COG3169@2 NA|NA|NA S Protein conserved in bacteria MAG.T1.5_00772 330214.NIDE0577 0.0 1291.6 Bacteria Bacteria COG0433@1,COG0433@2 NA|NA|NA S helicase activity MAG.T1.5_00773 330214.NIDE0578 0.0 1596.3 Bacteria exsG 3.1.3.3,3.1.4.17 ko:K01120,ko:K07315 ko00230,map00230 R00191,R01234 RC00296 ko00000,ko00001,ko01000,ko03021 Bacteria COG2202@1,COG2202@2,COG2203@1,COG2203@2,COG3290@1,COG3290@2,COG3829@1,COG3829@2,COG4585@1,COG4585@2 NA|NA|NA T protein histidine kinase activity MAG.T1.5_00774 330214.NIDE0579 3.5e-101 374.4 Nitrospirae ko:K02282 ko00000,ko02035,ko02044 Bacteria 3J12Q@40117,COG2197@1,COG2197@2 NA|NA|NA K Product type r regulator MAG.T1.5_00775 330214.NIDE0580 4.6e-107 394.0 Bacteria Bacteria COG2197@1,COG2197@2 NA|NA|NA K response regulator MAG.T1.5_00776 330214.NIDE0581 2.1e-53 214.9 Bacteria lpxC 3.5.1.108 ko:K02535 ko00540,ko01100,map00540,map01100 M00060 R04587 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko01005 Bacteria COG2204@1,COG2204@2 NA|NA|NA T phosphorelay signal transduction system MAG.T1.5_00777 330214.NIDE0582 0.0 2032.7 Bacteria 2.3.1.59,2.3.1.82 ko:K14658,ko:K17840,ko:K18815 M00664 br01600,ko00000,ko00002,ko01000,ko01504 Bacteria COG1752@1,COG1752@2,COG3153@1,COG3153@2 NA|NA|NA S transferase activity, transferring acyl groups MAG.T1.5_00778 330214.NIDE0583 3.4e-84 317.8 Bacteria yqhA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03535 ko00000,ko02000 2.A.1.14.1 Bacteria COG2862@1,COG2862@2 NA|NA|NA S Uncharacterized protein family, UPF0114 MAG.T1.5_00779 330214.NIDE0584 0.0 1506.1 Nitrospirae Bacteria 3J0ZF@40117,COG0642@1,COG0784@1,COG0784@2,COG2202@1,COG2202@2,COG2205@2 NA|NA|NA T PhoQ Sensor MAG.T1.5_00780 330214.NIDE0585 0.0 2337.4 Nitrospirae Bacteria 3J0ZF@40117,COG0784@1,COG0784@2,COG2202@1,COG2202@2,COG3829@1,COG3829@2,COG5002@1,COG5002@2 NA|NA|NA T Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_00781 330214.NIDE0586 3.9e-103 380.9 Bacteria Bacteria COG2197@1,COG2197@2 NA|NA|NA K response regulator MAG.T1.5_00783 330214.NIDE0587 1.9e-234 818.1 Nitrospirae 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 3J0DH@40117,COG0304@1,COG0304@2 NA|NA|NA I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP MAG.T1.5_00784 330214.NIDE0588 6.8e-221 773.1 Bacteria Bacteria 2Z87F@2,arCOG06766@1 NA|NA|NA MAG.T1.5_00785 330214.NIDE0589 8.5e-137 493.0 Nitrospirae sdiA GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010564,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032465,GO:0032467,GO:0032991,GO:0032993,GO:0043254,GO:0043565,GO:0044087,GO:0044089,GO:0044212,GO:0045787,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051302,GO:0051726,GO:0051781,GO:0060255,GO:0065007,GO:0080090,GO:0090068,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2000144,GO:2001141 ko:K07782,ko:K15852,ko:K18098,ko:K18304,ko:K19666,ko:K19731,ko:K19733,ko:K19734,ko:K20334,ko:K20540 ko02020,ko02024,ko02025,ko02026,map02020,map02024,map02025,map02026 M00644,M00769 ko00000,ko00001,ko00002,ko01504,ko03000 Bacteria 3J1CH@40117,COG2197@1,COG2197@2 NA|NA|NA K Autoinducer binding domain MAG.T1.5_00786 330214.NIDE0590 3.3e-175 620.9 Bacteria 1.4.3.21 ko:K00276 ko00260,ko00350,ko00360,ko00410,ko00950,ko00960,ko01100,ko01110,map00260,map00350,map00360,map00410,map00950,map00960,map01100,map01110 R02382,R02529,R02613,R03139,R04027,R04300,R06154,R06740 RC00062,RC00189,RC00676,RC01052 ko00000,ko00001,ko01000 Bacteria COG3733@1,COG3733@2 NA|NA|NA Q amine oxidase MAG.T1.5_00791 330214.NIDE0595 1.2e-308 1065.1 Nitrospirae uvrC GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016787,GO:0016788,GO:0030312,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1902494,GO:1905347,GO:1905348,GO:1990391 ko:K03703 ko03420,map03420 ko00000,ko00001,ko03400 Bacteria 3J0F1@40117,COG0322@1,COG0322@2 NA|NA|NA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision MAG.T1.5_00792 330214.NIDE0596 9.2e-153 546.2 Nitrospirae dapF 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0JV@40117,COG0253@1,COG0253@2 NA|NA|NA E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan MAG.T1.5_00793 330214.NIDE0597 5.3e-63 246.9 Nitrospirae gloA GO:0003674,GO:0003824,GO:0004462,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016151,GO:0016829,GO:0016846,GO:0019243,GO:0019752,GO:0032787,GO:0034641,GO:0042180,GO:0042182,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0046872,GO:0046914,GO:0051186,GO:0051596,GO:0061727,GO:0071704,GO:1901564,GO:1901575,GO:1901615 4.4.1.5 ko:K01759,ko:K15772 ko00620,ko02010,map00620,map02010 M00491 R02530 RC00004,RC00740 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.1.16,3.A.1.1.2 iAPECO1_1312.APECO1_733,iECABU_c1320.ECABU_c19040,iECED1_1282.ECED1_1851,iECNA114_1301.ECNA114_1699,iECOK1_1307.ECOK1_1770,iECP_1309.ECP_1597,iECS88_1305.ECS88_1700,iECSF_1327.ECSF_1514,iLF82_1304.LF82_0861,iNRG857_1313.NRG857_08275,iUMN146_1321.UM146_08895,iUTI89_1310.UTI89_C1842,ic_1306.c2044 Bacteria 3J15P@40117,COG0346@1,COG0346@2 NA|NA|NA E Glyoxalase-like domain MAG.T1.5_00794 330214.NIDE0598 5.1e-68 263.8 Bacteria 3.5.1.104 ko:K22278 ko00000,ko01000 Bacteria COG0454@1,COG0456@2 NA|NA|NA K acetyltransferase MAG.T1.5_00795 330214.NIDE0599 9.6e-105 386.3 Bacteria Bacteria COG0726@1,COG0726@2 NA|NA|NA G polysaccharide deacetylase MAG.T1.5_00796 330214.NIDE0600 7.7e-195 686.4 Nitrospirae rip3 GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0031224,GO:0031226,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 ko:K06212,ko:K06402 ko00000,ko01000,ko01002,ko02000 1.A.16.1.1,1.A.16.1.3 Bacteria 3J0VG@40117,COG0517@1,COG0517@2,COG1994@1,COG1994@2 NA|NA|NA S Belongs to the peptidase M50B family MAG.T1.5_00798 330214.NIDE0601 7.4e-139 500.0 Nitrospirae 1.17.99.6 ko:K07058,ko:K18979 ko00000,ko01000,ko03016 Bacteria 3J17V@40117,COG1295@1,COG1295@2 NA|NA|NA S Virulence factor BrkB MAG.T1.5_00799 330214.NIDE0602 3e-236 824.3 Nitrospirae nuoN GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 3J0FN@40117,COG1007@1,COG1007@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient MAG.T1.5_00800 330214.NIDE0603 8.3e-253 879.4 Nitrospirae nuoM 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 3J0EQ@40117,COG1008@1,COG1008@2 NA|NA|NA C Evidence 2a Function of homologous gene experimentally demonstrated in an other organism MAG.T1.5_00801 330214.NIDE0604 0.0 1177.2 Nitrospirae nuoL 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 3J0AN@40117,COG1009@1,COG1009@2 NA|NA|NA CP NADH-quinone oxidoreductase MAG.T1.5_00802 330214.NIDE0605 1.4e-39 168.7 Nitrospirae nuoK GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3 ko:K00340,ko:K05576 ko00190,ko01100,map00190,map01100 M00144,M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 3J0SN@40117,COG0713@1,COG0713@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient MAG.T1.5_00803 330214.NIDE0606 9.8e-62 243.0 Nitrospirae nuoJ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 3J0RP@40117,COG0839@1,COG0839@2 NA|NA|NA C Belongs to the complex I subunit 6 family MAG.T1.5_00804 330214.NIDE0607 2e-95 355.1 Nitrospirae nuoI GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3,1.6.99.3 ko:K00338,ko:K02573,ko:K03941 ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016 M00143,M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1,3.D.1.6 Bacteria 3J0N0@40117,COG1143@1,COG1143@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient MAG.T1.5_00805 330214.NIDE0608 5.5e-192 676.8 Nitrospirae nuoH GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 3J0E2@40117,COG1005@1,COG1005@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone MAG.T1.5_00806 330214.NIDE0609 0.0 1588.9 Nitrospirae hcnA 1.4.99.5,1.5.3.1 ko:K00302,ko:K10814 ko00260,ko00460,ko01100,ko01110,map00260,map00460,map01100,map01110 R00374,R00610,R05704 RC00060,RC00557,RC02808 ko00000,ko00001,ko01000,ko02042 Bacteria 3J0UR@40117,COG3383@1,COG3383@2 NA|NA|NA C Molydopterin dinucleotide binding domain MAG.T1.5_00807 330214.NIDE0611 2.7e-241 840.9 Nitrospirae nuoF2 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 3J0WX@40117,COG1894@1,COG1894@2 NA|NA|NA C NADH-ubiquinone oxidoreductase-F iron-sulfur binding region MAG.T1.5_00808 330214.NIDE0612 2.4e-90 338.2 Bacteria nuoE 1.6.5.3,1.6.99.3 ko:K00334,ko:K03943 ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016 M00143,M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1,3.D.1.6 Bacteria COG1905@1,COG1905@2 NA|NA|NA C 2 iron, 2 sulfur cluster binding MAG.T1.5_00810 330214.NIDE0613 0.0 1155.2 Nitrospirae nuoD GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00332,ko:K00333,ko:K13378 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 3J0FM@40117,COG0649@1,COG0649@2,COG0852@1,COG0852@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient MAG.T1.5_00811 330214.NIDE0614 3.5e-85 320.9 Nitrospirae nuoB 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 3J11S@40117,COG0377@1,COG0377@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient MAG.T1.5_00812 330214.NIDE0615 2.5e-59 234.6 Nitrospirae nuoA 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 3J0MS@40117,COG0838@1,COG0838@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient MAG.T1.5_00813 330214.NIDE0616 1.5e-207 728.8 Nitrospirae Bacteria 3J0P0@40117,COG1565@1,COG1565@2 NA|NA|NA S Putative S-adenosyl-L-methionine-dependent methyltransferase MAG.T1.5_00815 330214.NIDE0623 0.0 1667.9 Nitrospirae secA GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006457,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015627,GO:0015628,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042802,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061077,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:0098776,GO:1901265,GO:1901363,GO:1904680 ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 Bacteria 3J0E5@40117,COG0653@1,COG0653@2 NA|NA|NA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane MAG.T1.5_00821 330214.NIDE0628 5.7e-92 344.7 Nitrospirae ko:K03832 ko00000,ko02000 2.C.1.1 Bacteria 3J0U0@40117,COG0810@1,COG0810@2 NA|NA|NA M Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_00822 330214.NIDE0629 1.5e-87 328.9 Bacteria yneN Bacteria COG0526@1,COG0526@2 NA|NA|NA CO cell redox homeostasis MAG.T1.5_00824 330214.NIDE0631 1.6e-188 665.2 Bacteria Bacteria COG4313@1,COG4313@2 NA|NA|NA MAG.T1.5_00825 330214.NIDE0632 4.7e-222 776.9 Bacteria Bacteria COG4409@1,COG4409@2 NA|NA|NA G exo-alpha-(2->6)-sialidase activity MAG.T1.5_00826 330214.NIDE0633 8.3e-64 250.0 Bacteria Bacteria COG0526@1,COG0526@2 NA|NA|NA CO cell redox homeostasis MAG.T1.5_00828 330214.NIDE0635 1.8e-304 1051.6 Bacteria ko:K02014 ko00000,ko02000 1.B.14 Bacteria COG1629@1,COG4771@2 NA|NA|NA P transport MAG.T1.5_00829 330214.NIDE0636 4.7e-25 119.8 Bacteria Bacteria COG2452@1,COG2452@2 NA|NA|NA L recombinase activity MAG.T1.5_00830 330214.NIDE0637 2.2e-175 622.1 Bacteria ko:K07221 ko00000,ko02000 1.B.5.1 Bacteria COG1228@1,COG1228@2 NA|NA|NA Q imidazolonepropionase activity MAG.T1.5_00831 330214.NIDE0638 0.0 1349.3 Bacteria ko:K02014 ko00000,ko02000 1.B.14 Bacteria COG4772@1,COG4772@2 NA|NA|NA P TonB-dependent receptor MAG.T1.5_00832 330214.NIDE0638 0.0 1299.3 Bacteria ko:K02014 ko00000,ko02000 1.B.14 Bacteria COG4772@1,COG4772@2 NA|NA|NA P TonB-dependent receptor MAG.T1.5_00834 228410.NE0556 2.2e-278 964.9 Nitrosomonadales ko:K02014 ko00000,ko02000 1.B.14 Bacteria 1QTT0@1224,2WGP0@28216,374M9@32003,COG4773@1,COG4773@2 NA|NA|NA P InterPro IPR000531 COGs COG1629 MAG.T1.5_00835 228410.NE0550 1.6e-115 422.9 Nitrosomonadales Bacteria 1MXGY@1224,2VKWA@28216,372FU@32003,COG3182@1,COG3182@2 NA|NA|NA S PepSY-associated TM region MAG.T1.5_00836 330214.NIDE0639 1.3e-303 1048.5 Bacteria Bacteria COG1506@1,COG1506@2 NA|NA|NA E serine-type peptidase activity MAG.T1.5_00837 330214.NIDE0626 3.5e-137 495.0 Bacteria Bacteria COG4409@1,COG4409@2 NA|NA|NA G exo-alpha-(2->6)-sialidase activity MAG.T1.5_00838 153948.NAL212_1489 2.9e-81 310.1 Nitrosomonadales ko:K02014 ko00000,ko02000 1.B.14 Bacteria 1MUIH@1224,2VKC9@28216,372G4@32003,COG4772@1,COG4772@2 NA|NA|NA P TonB-dependent Receptor Plug Domain MAG.T1.5_00840 330214.NIDE0635 7.7e-215 753.8 Bacteria ko:K02014 ko00000,ko02000 1.B.14 Bacteria COG1629@1,COG4771@2 NA|NA|NA P transport MAG.T1.5_00841 330214.NIDE0646 3.8e-59 234.2 Bacteria exbB GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0017038,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 ko:K03561,ko:K03562 ko01120,map01120 ko00000,ko02000 1.A.30.2.1,1.A.30.2.2 Bacteria COG0811@1,COG0811@2 NA|NA|NA U bacteriocin transport MAG.T1.5_00842 330214.NIDE0647 2e-40 171.8 Bacteria exbD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03559 ko00000,ko02000 1.A.30.2.1 Bacteria COG0848@1,COG0848@2 NA|NA|NA U biopolymer transport protein MAG.T1.5_00844 330214.NIDE0641 0.0 1407.5 Bacteria ko:K02014 ko00000,ko02000 1.B.14 Bacteria COG4773@1,COG4773@2 NA|NA|NA P Receptor MAG.T1.5_00845 215803.DB30_2824 8.7e-76 290.8 Myxococcales cnrT Bacteria 1N3FA@1224,2WNEH@28221,2YXRF@29,42RW0@68525,COG0697@1,COG0697@2 NA|NA|NA EG EamA-like transporter family MAG.T1.5_00847 330214.NIDE0644 0.0 1309.3 Bacteria ko:K02014 ko00000,ko02000 1.B.14 Bacteria COG4773@1,COG4773@2 NA|NA|NA P Receptor MAG.T1.5_00848 330214.NIDE0645 5.3e-175 620.5 Bacteria Bacteria COG3182@1,COG3182@2 NA|NA|NA E Iron-regulated membrane protein MAG.T1.5_00849 330214.NIDE0648 0.0 1443.7 Bacteria ko:K02014 ko00000,ko02000 1.B.14 Bacteria COG4772@1,COG4772@2 NA|NA|NA P TonB-dependent receptor MAG.T1.5_00851 857087.Metme_2895 8.6e-185 654.1 Methylococcales ko:K02014 ko00000,ko02000 1.B.14 Bacteria 1QTT0@1224,1RNBT@1236,1XEVS@135618,COG4773@1,COG4773@2 NA|NA|NA P TIGRFAM TonB-dependent siderophore receptor MAG.T1.5_00853 330214.NIDE0650 0.0 1222.2 Bacteria iutA ko:K02014 ko00000,ko02000 1.B.14 Bacteria COG1629@1,COG4771@2 NA|NA|NA P transport MAG.T1.5_00854 330214.NIDE0660 1.5e-206 725.3 Nitrospirae ko:K07133 ko00000 Bacteria 3J14P@40117,COG1373@1,COG1373@2 NA|NA|NA S AAA domain MAG.T1.5_00856 330214.NIDE0662 2.2e-216 758.1 Bacteria Bacteria COG3182@1,COG3182@2 NA|NA|NA E Iron-regulated membrane protein MAG.T1.5_00857 330214.NIDE0664 1.6e-174 619.0 Bacteria acrA ko:K02005 ko00000 Bacteria COG0845@1,COG0845@2 NA|NA|NA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family MAG.T1.5_00858 330214.NIDE0665 8.9e-119 433.0 Nitrospirae ko:K02003 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 3J10N@40117,COG1136@1,COG1136@2 NA|NA|NA V Evidence 2b Function of strongly homologous gene MAG.T1.5_00859 330214.NIDE0666 1.4e-204 718.8 Bacteria ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria COG0577@1,COG0577@2 NA|NA|NA V efflux transmembrane transporter activity MAG.T1.5_00860 330214.NIDE0667 1e-202 712.6 Bacteria ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria COG0577@1,COG0577@2 NA|NA|NA V efflux transmembrane transporter activity MAG.T1.5_00862 228410.NE0559 5.9e-162 578.2 Nitrosomonadales ko:K02014 ko00000,ko02000 1.B.14 Bacteria 1QTT0@1224,2WGP0@28216,374M9@32003,COG4773@1,COG4773@2 NA|NA|NA P InterPro IPR000531 COGs COG1629 MAG.T1.5_00863 335283.Neut_1727 3e-125 455.3 Nitrosomonadales Bacteria 1MXGY@1224,2VKZZ@28216,373ZG@32003,COG3182@1,COG3182@2 NA|NA|NA S PepSY-associated TM region MAG.T1.5_00864 330214.NIDE0669 3.3e-31 140.6 Bacteria Bacteria COG2452@1,COG2452@2 NA|NA|NA L recombinase activity MAG.T1.5_00865 330214.NIDE0670 6.3e-75 287.0 Bacteria Bacteria 2BVVW@1,32175@2 NA|NA|NA S Cytochrome P460 MAG.T1.5_00871 330214.NIDE0676 8.5e-75 286.6 Nitrospirae slp GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0016020,GO:0019867,GO:0042802 ko:K07285 ko00000 Bacteria 3J1BB@40117,COG3065@1,COG3065@2 NA|NA|NA M Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_00872 330214.NIDE0677 5.8e-104 383.6 Bacteria dsbA GO:0003674,GO:0003756,GO:0003824,GO:0005575,GO:0005623,GO:0006457,GO:0008150,GO:0008152,GO:0009987,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071236,GO:0140096 ko:K03673 ko01503,map01503 M00728 ko00000,ko00001,ko00002,ko03110 iEcSMS35_1347.EcSMS35_4241 Bacteria COG1651@1,COG1651@2 NA|NA|NA O Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process MAG.T1.5_00873 330214.NIDE0678 0.0 1487.6 Nitrospirae pacS GO:0000041,GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0008150,GO:0015677,GO:0016020,GO:0030001,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0051179,GO:0051234,GO:0071944 3.6.3.4,3.6.3.54 ko:K01533,ko:K17686 ko01524,ko04016,map01524,map04016 R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 Bacteria 3J0CY@40117,COG2217@1,COG2217@2 NA|NA|NA P E1-E2 ATPase MAG.T1.5_00874 330214.NIDE0681 1.9e-243 848.2 Nitrospirae htrA GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 Bacteria 3J0X9@40117,COG0265@1,COG0265@2 NA|NA|NA M Evidence 2a Function of homologous gene experimentally demonstrated in an other organism MAG.T1.5_00877 330214.NIDE0685 5e-55 221.1 Bacteria ko:K02456,ko:K02650,ko:K02679,ko:K08084 ko02020,ko03070,ko05111,map02020,map03070,map05111 M00331 ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 Bacteria COG2165@1,COG2165@2 NA|NA|NA NU general secretion pathway protein MAG.T1.5_00878 330214.NIDE0686 0.0 1249.2 Nitrospirae Bacteria 3J10H@40117,COG0784@1,COG0784@2,COG2203@1,COG2203@2,COG4191@1,COG4191@2 NA|NA|NA T Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_00879 330214.NIDE0687 3.6e-149 534.6 Nitrospirae ko:K07814 ko00000,ko02022 Bacteria 3J0ID@40117,COG3437@1,COG3437@2 NA|NA|NA T response regulator MAG.T1.5_00880 330214.NIDE0688 7e-66 256.5 Bacteria nikR GO:0000976,GO:0000984,GO:0000985,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016043,GO:0016151,GO:0019219,GO:0019222,GO:0022607,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0032991,GO:0032993,GO:0042802,GO:0043167,GO:0043169,GO:0043254,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071840,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 ko:K07722 ko00000,ko03000 Bacteria COG0864@1,COG0864@2 NA|NA|NA K response to nickel cation MAG.T1.5_00881 330214.NIDE0689 3.2e-50 204.5 Nitrospirae Bacteria 2AIN5@1,3194H@2,3J1DR@40117 NA|NA|NA S Domain of unknown function (DUF3842) MAG.T1.5_00882 330214.NIDE0690 0.0 1184.9 Bacteria Bacteria COG4772@1,COG4772@2 NA|NA|NA P TonB-dependent receptor MAG.T1.5_00883 504728.K649_12140 6.3e-150 537.0 Deinococcus-Thermus dys 2.5.1.46 ko:K00809 ko00000,ko01000 Bacteria 1WI9Q@1297,COG1899@1,COG1899@2 NA|NA|NA O Deoxyhypusine synthase MAG.T1.5_00884 379066.GAU_3200 2.7e-93 348.6 Gemmatimonadetes hldD 5.1.3.20 ko:K03274 ko00540,ko01100,map00540,map01100 M00064 R05176 RC01291 ko00000,ko00001,ko00002,ko01000,ko01005 Bacteria 1ZUKD@142182,COG0451@1,COG0451@2 NA|NA|NA GM Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose MAG.T1.5_00885 330214.NIDE0691 1.8e-67 262.3 Bacteria mpg GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.2.2.21 ko:K03652 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria COG2094@1,COG2094@2 NA|NA|NA L Belongs to the DNA glycosylase MPG family MAG.T1.5_00888 330214.NIDE0694 0.0 1091.6 Nitrospirae 2.7.13.3 ko:K02482 ko00000,ko01000,ko01001,ko02022 Bacteria 3J117@40117,COG2203@1,COG2203@2,COG4191@1,COG4191@2 NA|NA|NA T His Kinase A (phosphoacceptor) domain MAG.T1.5_00889 330214.NIDE0695 3.2e-56 224.6 Nitrospirae yvlD ko:K08972 ko00000 Bacteria 3J19X@40117,COG1950@1,COG1950@2 NA|NA|NA S Mycobacterial 4 TMS phage holin, superfamily IV MAG.T1.5_00891 330214.NIDE0698 1.5e-96 359.0 Bacteria copM ko:K03611 ko00000,ko03110 5.A.2.1 Bacteria COG2010@1,COG2010@2 NA|NA|NA C Cytochrome c MAG.T1.5_00892 330214.NIDE0699 5.4e-123 447.2 Nitrospirae cruF 5.5.1.19 ko:K22502 ko00906,map00906 R03824,R05341 RC01004 ko00000,ko00001,ko01000 Bacteria 3J195@40117,COG2324@1,COG2324@2 NA|NA|NA S Carotenoid biosynthesis protein MAG.T1.5_00893 330214.NIDE0700 1.9e-178 631.7 Nitrospirae dfrA 1.1.1.219 ko:K00091 ko00000,ko01000 Bacteria 3J0T9@40117,COG0451@1,COG0451@2 NA|NA|NA M NmrA-like family MAG.T1.5_00894 330214.NIDE0701 3.2e-161 574.3 Nitrospirae ispA GO:0003674,GO:0003824,GO:0004161,GO:0004311,GO:0004337,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009536,GO:0009842,GO:0009987,GO:0016114,GO:0016740,GO:0016765,GO:0019637,GO:0033383,GO:0033384,GO:0033385,GO:0033386,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0045337,GO:0045338,GO:0071704,GO:0090407,GO:1901576 2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90 ko:K00795,ko:K02523,ko:K13789 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00366 R01658,R02003,R02061,R09248 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 iPC815.YPO3176,iSFV_1184.SFV_0386 Bacteria 3J0H1@40117,COG0142@1,COG0142@2 NA|NA|NA H Polyprenyl synthetase MAG.T1.5_00899 330214.NIDE0715 1.6e-98 365.5 Bacteria Bacteria 2E469@1,32Z27@2 NA|NA|NA MAG.T1.5_00902 330214.NIDE0719 7.5e-192 676.4 Bacteria Bacteria 28IX1@1,2Z8V3@2 NA|NA|NA S Protein of unknown function (DUF2914) MAG.T1.5_00903 330214.NIDE0505 8.9e-38 162.9 Bacteria Bacteria COG4446@1,COG4446@2 NA|NA|NA P Protein conserved in bacteria MAG.T1.5_00904 330214.NIDE0720 3.3e-129 468.0 Bacteria Bacteria COG4714@1,COG4714@2 NA|NA|NA EGP membrane-anchored protein conserved in bacteria MAG.T1.5_00905 330214.NIDE0721 3.2e-119 434.5 Bacteria spoIVFB ko:K06402 ko00000,ko01000,ko01002 Bacteria COG1994@1,COG1994@2 NA|NA|NA S metallopeptidase activity MAG.T1.5_00906 330214.NIDE0722 3.5e-102 377.9 Bacteria Bacteria COG1018@1,COG1018@2 NA|NA|NA C nitric oxide dioxygenase activity MAG.T1.5_00907 330214.NIDE0724 3.2e-77 294.3 Bacteria speD 2.5.1.16,4.1.1.50 ko:K00797,ko:K01611 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R00178,R01920,R02869,R08359 RC00021,RC00053,RC00299 ko00000,ko00001,ko00002,ko01000 Bacteria COG1586@1,COG1586@2 NA|NA|NA E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine MAG.T1.5_00908 330214.NIDE0725 1.6e-47 195.3 Bacteria Bacteria COG3255@1,COG3255@2 NA|NA|NA I Sterol carrier protein MAG.T1.5_00909 330214.NIDE0726 0.0 1876.7 Nitrospirae Bacteria 3J0ZG@40117,COG0841@1,COG0841@2 NA|NA|NA V AcrB/AcrD/AcrF family MAG.T1.5_00910 330214.NIDE0727 2.7e-195 688.0 Nitrospirae ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 Bacteria 3J15F@40117,COG0845@1,COG0845@2 NA|NA|NA M HlyD family secretion protein MAG.T1.5_00911 330214.NIDE0728 5.7e-99 367.1 Nitrospirae acrR Bacteria 3J1CN@40117,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family MAG.T1.5_00914 330214.NIDE0732 1.1e-81 309.3 Bacteria ppd 4.1.1.82 ko:K09459 ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130 R04053 RC00506 ko00000,ko00001,ko01000 Bacteria COG4032@1,COG4032@2 NA|NA|NA EH Thiamine pyrophosphate enzyme, N-terminal TPP binding domain MAG.T1.5_00915 330214.NIDE0733 2e-95 355.1 Bacteria 4.1.1.82 ko:K09459 ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130 R04053 RC00506 ko00000,ko00001,ko01000 Bacteria COG0028@1,COG0028@2 NA|NA|NA EH Belongs to the TPP enzyme family MAG.T1.5_00916 330214.NIDE0734 5.5e-179 633.6 Nitrospirae phnW GO:0003674,GO:0003824 2.5.1.49,2.6.1.37,3.11.1.1 ko:K01740,ko:K03430,ko:K05306,ko:K09469 ko00270,ko00440,ko01100,ko01120,map00270,map00440,map01100,map01120 R00747,R01287,R04152,R04859 RC00008,RC00020,RC00062,RC00368,RC02821,RC02848 ko00000,ko00001,ko01000,ko01007 Bacteria 3J0FC@40117,COG0075@1,COG0075@2 NA|NA|NA E Evidence 2b Function of strongly homologous gene MAG.T1.5_00917 330214.NIDE0735 3.9e-125 454.1 Nitrospirae 2.7.7.74,5.4.2.9 ko:K01841,ko:K07281 ko00440,ko00562,ko01100,ko01120,ko01130,map00440,map00562,map01100,map01120,map01130 R00661,R09669 RC00002,RC02792 ko00000,ko00001,ko01000 Bacteria 3J1BZ@40117,COG1213@1,COG1213@2 NA|NA|NA M Nucleotidyl transferase MAG.T1.5_00918 330214.NIDE0736 5.5e-227 793.5 Bacteria 2.7.7.99 ko:K00992 ko00520,ko01100,map00520,map01100 R11025 RC00002 ko00000,ko00001,ko01000 Bacteria COG0558@1,COG0558@2,COG1208@1,COG1208@2 NA|NA|NA JM COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon MAG.T1.5_00919 330214.NIDE0737 7.1e-149 533.5 Bacteria ko:K07027 ko00000,ko02000 4.D.2 Bacteria COG0392@1,COG0392@2 NA|NA|NA M lysyltransferase activity MAG.T1.5_00920 330214.NIDE0738 7.3e-194 683.3 Nitrospirae 2.4.1.83 ko:K00721,ko:K20534 ko00510,ko01100,map00510,map01100 R01009 RC00005 ko00000,ko00001,ko01000,ko01003,ko01005,ko02000 4.D.2.1.9 GT2 Bacteria 3J13V@40117,COG0463@1,COG0463@2 NA|NA|NA M Glycosyltransferase like family 2 MAG.T1.5_00921 330214.NIDE0739 1e-157 563.1 Bacteria ko:K00754 ko00000,ko01000 GT4 Bacteria COG0438@1,COG0438@2 NA|NA|NA M transferase activity, transferring glycosyl groups MAG.T1.5_00922 330214.NIDE0740 9.8e-192 676.0 Bacteria Bacteria COG0438@1,COG0438@2 NA|NA|NA M transferase activity, transferring glycosyl groups MAG.T1.5_00923 330214.NIDE0741 1.5e-166 592.8 Bacteria Bacteria COG2244@1,COG2244@2 NA|NA|NA S polysaccharide biosynthetic process MAG.T1.5_00924 330214.NIDE0742 1.7e-112 412.5 Bacteria ywdF GO:0003674,GO:0003824,GO:0016740,GO:0016757 ko:K20444 ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 Bacteria COG1216@1,COG1216@2 NA|NA|NA V Glycosyl transferase, family 2 MAG.T1.5_00925 330214.NIDE0743 1.4e-184 652.5 Bacteria Bacteria COG3875@1,COG3875@2 NA|NA|NA S lactate racemase activity MAG.T1.5_00926 330214.NIDE0744 2.1e-262 911.4 Bacteria ko:K14340 ko00000,ko01000,ko01003 Bacteria COG1807@1,COG1807@2 NA|NA|NA M 4-amino-4-deoxy-L-arabinose transferase activity MAG.T1.5_00927 243231.GSU0538 8.2e-17 93.6 Desulfuromonadales hspA-1 ko:K13993 ko04141,map04141 ko00000,ko00001,ko03110 Bacteria 1N7C7@1224,2WQ7I@28221,42U0T@68525,43UXA@69541,COG0071@1,COG0071@2 NA|NA|NA O Hsp20/alpha crystallin family MAG.T1.5_00929 765911.Thivi_1781 3.6e-08 63.5 Chromatiales Bacteria 1NE58@1224,1SG82@1236,1X20I@135613,2DPTZ@1,333CW@2 NA|NA|NA MAG.T1.5_00930 330214.NIDE0747 0.0 1207.6 Nitrospirae cstA GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042594,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:0071944 ko:K06200 ko00000 Bacteria 3J10E@40117,COG1966@1,COG1966@2 NA|NA|NA T 5TM C-terminal transporter carbon starvation CstA MAG.T1.5_00931 330214.NIDE0748 8.3e-66 256.5 Nitrospirae yajQ GO:0000049,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0009987,GO:0017076,GO:0019001,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033554,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0097159,GO:0097367,GO:1901265,GO:1901363 ko:K09767 ko00000 Bacteria 3J135@40117,COG1666@1,COG1666@2 NA|NA|NA S Protein of unknown function (DUF520) MAG.T1.5_00932 330214.NIDE0749 5.8e-106 391.0 Bacteria hcf136 Bacteria COG4447@1,COG4447@2 NA|NA|NA S cellulose binding MAG.T1.5_00934 330214.NIDE0751 5.3e-229 800.0 Bacteria asnS GO:0003674,GO:0003824,GO:0004812,GO:0004816,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006421,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.22 ko:K01893 ko00970,map00970 M00359,M00360 R03648 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria COG0017@1,COG0017@2 NA|NA|NA J Asparaginyl-tRNA synthetase MAG.T1.5_00935 330214.NIDE0753 6.6e-141 506.9 Nitrospirae rsmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 ko:K03438 ko00000,ko01000,ko03009 Bacteria 3J0NU@40117,COG0275@1,COG0275@2 NA|NA|NA J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA MAG.T1.5_00936 330214.NIDE0754 9.8e-47 192.6 Bacteria Bacteria 2DT1T@1,33IAD@2 NA|NA|NA S Evidence 5 No homology to any previously reported sequences MAG.T1.5_00937 330214.NIDE0755 2.8e-302 1043.9 Nitrospirae ftsI GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.4.16.4 ko:K03587,ko:K08384,ko:K08724,ko:K12552,ko:K12556 ko00550,ko01100,ko01501,map00550,map01100,map01501 ko00000,ko00001,ko01000,ko01011,ko03036 Bacteria 3J0FH@40117,COG0768@1,COG0768@2 NA|NA|NA M Penicillin-binding Protein dimerisation domain MAG.T1.5_00938 330214.NIDE0756 1.3e-226 792.3 Nitrospirae murE GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.10,6.3.2.13,6.3.2.7 ko:K01928,ko:K05362,ko:K15792 ko00300,ko00550,ko01100,map00300,map00550,map01100 R02786,R02788,R04617 RC00064,RC00090,RC00141 ko00000,ko00001,ko01000,ko01011 Bacteria 3J0DS@40117,COG0769@1,COG0769@2 NA|NA|NA M acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan MAG.T1.5_00939 330214.NIDE0757 7.5e-240 836.3 Nitrospirae murF 6.3.2.10,6.3.2.13 ko:K01929,ko:K15792 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 R02788,R04573,R04617 RC00064,RC00090,RC00141 ko00000,ko00001,ko01000,ko01011 Bacteria 3J0PW@40117,COG0770@1,COG0770@2 NA|NA|NA M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein MAG.T1.5_00940 330214.NIDE0758 6.2e-191 673.3 Nitrospirae mraY GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 iAF987.Gmet_0409,iEC042_1314.EC042_0088,iECABU_c1320.ECABU_c00920,iECED1_1282.ECED1_0088,iECH74115_1262.ECH74115_0095,iECSP_1301.ECSP_0090,iECs_1301.ECs0091,iG2583_1286.G2583_0091,iSDY_1059.SDY_0117,iZ_1308.Z0097,ic_1306.c0105 Bacteria 3J0C4@40117,COG0472@1,COG0472@2 NA|NA|NA M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan MAG.T1.5_00941 330214.NIDE0759 2.6e-234 817.8 Nitrospirae murD GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008764,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 iAPECO1_1312.APECO1_1898,iECNA114_1301.ECNA114_0081,iECOK1_1307.ECOK1_0089,iECP_1309.ECP_0090,iECS88_1305.ECS88_0091,iECSF_1327.ECSF_0098,iLF82_1304.LF82_1418,iNRG857_1313.NRG857_00450,iUMN146_1321.UM146_23225,iUTI89_1310.UTI89_C0097 Bacteria 3J0HT@40117,COG0771@1,COG0771@2 NA|NA|NA M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) MAG.T1.5_00942 330214.NIDE0760 3.2e-183 647.9 Nitrospirae ftsW GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008360,GO:0009987,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032153,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051179,GO:0051234,GO:0051301,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:1901264,GO:1901505 2.4.1.227 ko:K02563,ko:K03588 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011,ko02000,ko03036 2.A.103.1 GT28 Bacteria 3J0M8@40117,COG0772@1,COG0772@2 NA|NA|NA D Cell cycle protein MAG.T1.5_00943 330214.NIDE0761 1.1e-169 602.8 Nitrospirae murG GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0050511,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 GT28 iLJ478.TM0232,iSFV_1184.SFV_0083,iSF_1195.SF0087,iSFxv_1172.SFxv_0091,iS_1188.S0089 Bacteria 3J0JS@40117,COG0707@1,COG0707@2 NA|NA|NA M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) MAG.T1.5_00944 330214.NIDE0762 6.1e-253 879.8 Nitrospirae murC GO:0000166,GO:0000270,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034645,GO:0035639,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 iECP_1309.ECP_0093,iJN678.murC Bacteria 3J0D5@40117,COG0773@1,COG0773@2 NA|NA|NA M Belongs to the MurCDEF family MAG.T1.5_00945 330214.NIDE0763 5.9e-150 537.0 Nitrospirae murB GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008360,GO:0008762,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0022603,GO:0022604,GO:0030203,GO:0034645,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045229,GO:0048037,GO:0050660,GO:0050662,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0055114,GO:0065007,GO:0065008,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.3.1.98,6.3.2.4 ko:K00075,ko:K01921 ko00473,ko00520,ko00550,ko01100,ko01502,map00473,map00520,map00550,map01100,map01502 R01150,R03191,R03192 RC00064,RC00141,RC02639 ko00000,ko00001,ko01000,ko01011 iECED1_1282.ECED1_4683,iECUMN_1333.ECUMN_4498_AT6,iIT341.HP1418,iLF82_1304.LF82_1416,iNRG857_1313.NRG857_19845,iYO844.BSU15230 Bacteria 3J0Q1@40117,COG0812@1,COG0812@2 NA|NA|NA M Cell wall formation MAG.T1.5_00946 330214.NIDE0764 6.4e-152 543.5 Nitrospirae ddl 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 Bacteria 3J0JM@40117,COG1181@1,COG1181@2 NA|NA|NA F Cell wall formation MAG.T1.5_00947 330214.NIDE0765 1.6e-141 508.8 Bacteria ftsQ GO:0000003,GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0019954,GO:0022402,GO:0022414,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032505,GO:0032506,GO:0040007,GO:0042802,GO:0043093,GO:0044085,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047 6.3.2.4 ko:K01921,ko:K03589,ko:K06438 ko00473,ko00550,ko01100,ko01502,ko04112,map00473,map00550,map01100,map01502,map04112 R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011,ko03036 Bacteria COG1589@1,COG1589@2 NA|NA|NA D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly MAG.T1.5_00948 330214.NIDE0766 5.6e-228 796.6 Nitrospirae ftsA GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0017076,GO:0030554,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363 ko:K03590 ko04112,map04112 ko00000,ko00001,ko03036,ko04812 Bacteria 3J0Q3@40117,COG0849@1,COG0849@2 NA|NA|NA D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring MAG.T1.5_00949 330214.NIDE0767 2.9e-213 747.7 Nitrospirae ftsZ GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 ko:K03531 ko04112,map04112 ko00000,ko00001,ko02048,ko03036,ko04812 Bacteria 3J0D4@40117,COG0206@1,COG0206@2 NA|NA|NA D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity MAG.T1.5_00950 330214.NIDE0768 4.1e-101 374.4 Nitrospirae yfiH GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0071944 ko:K05810 ko00000,ko01000 Bacteria 3J0TC@40117,COG1496@1,COG1496@2 NA|NA|NA S Belongs to the multicopper oxidase YfiH RL5 family MAG.T1.5_00951 330214.NIDE0769 2.4e-98 365.2 Nitrospirae yggS GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 ko:K06997 ko00000 Bacteria 3J0RJ@40117,COG0325@1,COG0325@2 NA|NA|NA S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis MAG.T1.5_00952 330214.NIDE0770 1.7e-113 415.6 Nitrospirae proC GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0017144,GO:0018130,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0055114,GO:0055129,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_0899,iIT341.HP1158,iSBO_1134.SBO_0282,ic_1306.c0493 Bacteria 3J0N8@40117,COG0345@1,COG0345@2 NA|NA|NA E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline MAG.T1.5_00953 330214.NIDE0771 8.2e-45 186.0 Nitrospirae yggT GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02221 ko00000,ko02044 Bacteria 3J0U5@40117,COG0762@1,COG0762@2 NA|NA|NA S YGGT family MAG.T1.5_00954 330214.NIDE0772 3.7e-61 241.1 Nitrospirae divIVA ko:K04074 ko00000,ko03036 Bacteria 3J19M@40117,COG3599@1,COG3599@2 NA|NA|NA D DivIVA protein MAG.T1.5_00955 330214.NIDE0773 4.5e-152 544.3 Nitrospirae 3.4.16.4 ko:K21469 ko00550,map00550 ko00000,ko00001,ko01000,ko01002,ko01011 Bacteria 3J131@40117,COG1680@1,COG1680@2 NA|NA|NA V Beta-lactamase MAG.T1.5_00957 330214.NIDE0775 4.3e-84 317.4 Nitrospirae pgsA-2 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 Bacteria 3J183@40117,COG0558@1,COG0558@2 NA|NA|NA I CDP-alcohol phosphatidyltransferase MAG.T1.5_00959 330214.NIDE0777 8.8e-210 736.1 Nitrospirae pilC ko:K02653 ko00000,ko02035,ko02044 3.A.15.2 Bacteria 3J0HZ@40117,COG1459@1,COG1459@2 NA|NA|NA U Type II secretion system (T2SS), protein F MAG.T1.5_00960 330214.NIDE0778 4.1e-282 976.9 Bacteria pilS 2.7.13.3 ko:K02668 ko02020,map02020 M00501 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 Bacteria COG5000@1,COG5000@2 NA|NA|NA T phosphorelay sensor kinase activity MAG.T1.5_00961 330214.NIDE0779 2.1e-244 851.3 Bacteria pilR ko:K02667 ko02020,map02020 M00501 ko00000,ko00001,ko00002,ko02022,ko02035 Bacteria COG2204@1,COG2204@2 NA|NA|NA T phosphorelay signal transduction system MAG.T1.5_00962 330214.NIDE0780 1.7e-108 399.1 Nitrospirae ispE GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006629,GO:0006720,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0050515,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901576 2.1.1.182,2.7.1.148 ko:K00919,ko:K02528,ko:K16924 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096,M00582 R05634,R10716 RC00002,RC00003,RC01439,RC03257 ko00000,ko00001,ko00002,ko01000,ko02000,ko03009 3.A.1.29 iEC55989_1330.EC55989_1304,iLJ478.TM1383,iYO844.BSU00460 Bacteria 3J0N1@40117,COG1947@1,COG1947@2 NA|NA|NA F Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol MAG.T1.5_00963 330214.NIDE0781 9.6e-164 582.8 Nitrospirae prs GO:0003674,GO:0003824,GO:0004749,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016772,GO:0016778,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2848 Bacteria 3J0D0@40117,COG0462@1,COG0462@2 NA|NA|NA F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) MAG.T1.5_00964 330214.NIDE0782 6.5e-102 377.1 Nitrospirae ctc GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02897 ko03010,map03010 M00178 ko00000,ko00001,ko00002,ko03011 Bacteria 3J0NK@40117,COG1825@1,COG1825@2 NA|NA|NA J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance MAG.T1.5_00965 330214.NIDE0783 7.1e-93 346.7 Nitrospirae pth GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016787,GO:0016788,GO:0040007,GO:0044464,GO:0052689,GO:0071944,GO:0140098,GO:0140101 3.1.1.29 ko:K01056 ko00000,ko01000,ko03012 Bacteria 3J0QR@40117,COG0193@1,COG0193@2 NA|NA|NA J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis MAG.T1.5_00966 330214.NIDE0784 2.1e-195 688.3 Bacteria 1.13.11.52 ko:K00463 ko00380,ko01100,ko05143,map00380,map01100,map05143 M00038 R00678,R02702,R02909,R03628 RC00356 ko00000,ko00001,ko00002,ko01000 Bacteria COG5274@1,COG5274@2 NA|NA|NA C heme binding MAG.T1.5_00968 330214.NIDE0786 6.9e-89 333.6 Bacteria ko:K16079 ko00000,ko02000 1.B.4.2.1 Bacteria COG3637@1,COG3637@2 NA|NA|NA M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety MAG.T1.5_00970 330214.NIDE0789 4.2e-51 207.2 Nitrospirae rpsF GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048027,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 4.3.1.19 ko:K01754,ko:K02990 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,ko03010,map00260,map00290,map01100,map01110,map01130,map01200,map01230,map03010 M00178,M00570 R00220,R00996 RC00418,RC02600 br01610,ko00000,ko00001,ko00002,ko01000,ko03011,ko03029 Bacteria 3J0VS@40117,COG0360@1,COG0360@2 NA|NA|NA J Binds together with S18 to 16S ribosomal RNA MAG.T1.5_00971 330214.NIDE0790 3e-66 257.7 Nitrospirae ssb ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 ko00000,ko00001,ko03029,ko03032,ko03400 Bacteria 3J0NB@40117,COG0629@1,COG0629@2 NA|NA|NA L Single-strand binding protein family MAG.T1.5_00972 1121396.KB893079_gene809 1.1e-18 99.0 Desulfobacterales rpsR GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02963 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1MZ8U@1224,2MKM0@213118,2WR7Z@28221,42VJQ@68525,COG0238@1,COG0238@2 NA|NA|NA J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit MAG.T1.5_00973 330214.NIDE0792 1.3e-76 292.7 Nitrospirae yceD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 ko:K07040 ko00000 Bacteria 3J0UQ@40117,COG1399@1,COG1399@2 NA|NA|NA S Uncharacterized ACR, COG1399 MAG.T1.5_00974 500633.CLOHIR_01133 1.7e-11 74.7 Clostridia rpmF GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904 ko:K02911 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011,ko03029 Bacteria 1VEFI@1239,24QM0@186801,COG0333@1,COG0333@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL32 family MAG.T1.5_00975 330214.NIDE0794 2.1e-180 638.3 Nitrospirae plsX 1.21.4.2,1.21.4.3,1.21.4.4,2.3.1.15 ko:K03621,ko:K21576,ko:K21577 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 3J0DY@40117,COG0416@1,COG0416@2 NA|NA|NA I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA MAG.T1.5_00976 330214.NIDE0795 1.4e-159 568.9 Nitrospirae fabH 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 3J0FW@40117,COG0332@1,COG0332@2 NA|NA|NA I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids MAG.T1.5_00977 330214.NIDE0796 3.8e-144 517.7 Nitrospirae fabD GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 iEcE24377_1341.EcE24377A_1213,iJN746.PP_1913,iPC815.YPO1598 Bacteria 3J0IX@40117,COG0331@1,COG0331@2 NA|NA|NA I Acyl transferase domain MAG.T1.5_00978 330214.NIDE0797 5e-123 447.2 Nitrospirae Bacteria 3J0J6@40117,COG1028@1,COG1028@2 NA|NA|NA IQ Evidence 2a Function of homologous gene experimentally demonstrated in an other organism MAG.T1.5_00979 330214.NIDE0798 7.6e-31 139.8 Nitrospirae acpP GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 ko:K02078 ko00000,ko00001 Bacteria 3J0RX@40117,COG0236@1,COG0236@2 NA|NA|NA IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis MAG.T1.5_00980 330214.NIDE0799 8.1e-227 792.7 Nitrospirae fabF GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0033817,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 iAF1260.b1095,iAPECO1_1312.APECO1_176,iB21_1397.B21_01099,iBWG_1329.BWG_0943,iE2348C_1286.E2348C_1187,iEC042_1314.EC042_1165,iEC55989_1330.EC55989_1207,iECABU_c1320.ECABU_c13085,iECBD_1354.ECBD_2506,iECB_1328.ECB_01091,iECDH10B_1368.ECDH10B_1167,iECDH1ME8569_1439.ECDH1ME8569_1030,iECD_1391.ECD_01091,iECED1_1282.ECED1_1238,iECH74115_1262.ECH74115_1474,iECIAI1_1343.ECIAI1_1130,iECIAI39_1322.ECIAI39_2066,iECO103_1326.ECO103_1140,iECO111_1330.ECO111_1372,iECO26_1355.ECO26_1428,iECOK1_1307.ECOK1_1202,iECP_1309.ECP_1087,iECS88_1305.ECS88_1109,iECSE_1348.ECSE_1159,iECSF_1327.ECSF_0994,iECSP_1301.ECSP_1396,iECUMN_1333.ECUMN_1270,iECW_1372.ECW_m1203,iECs_1301.ECs1473,iEKO11_1354.EKO11_2739,iETEC_1333.ETEC_1160,iEcDH1_1363.EcDH1_2552,iEcE24377_1341.EcE24377A_1216,iEcSMS35_1347.EcSMS35_2032,iG2583_1286.G2583_1355,iJO1366.b1095,iJR904.b1095,iLF82_1304.LF82_0607,iNRG857_1313.NRG857_05280,iSF_1195.SF1099,iSFxv_1172.SFxv_1251,iS_1188.S1179,iUMN146_1321.UM146_11850,iWFL_1372.ECW_m1203,iY75_1357.Y75_RS05720,iZ_1308.Z1734,ic_1306.c1365 Bacteria 3J0DH@40117,COG0304@1,COG0304@2 NA|NA|NA I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP MAG.T1.5_00981 330214.NIDE0800 2.1e-102 378.6 Nitrospirae rnc GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3,3.1.3.97 ko:K03685,ko:K07053 ko03008,ko05205,map03008,map05205 R00188,R11188 RC00078 ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 Bacteria 3J119@40117,COG0571@1,COG0571@2 NA|NA|NA J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism MAG.T1.5_00982 330214.NIDE0801 5.7e-99 367.1 Nitrospirae ppiB 5.2.1.8 ko:K01802,ko:K03768 ko00000,ko01000,ko03110 Bacteria 3J18H@40117,COG0652@1,COG0652@2 NA|NA|NA O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides MAG.T1.5_00983 330214.NIDE0337 1.9e-47 195.3 Bacteria nicK ko:K07467 ko00000 Bacteria COG2946@1,COG2946@2 NA|NA|NA L Replication initiation factor MAG.T1.5_00988 1220583.GOACH_39_00150 2.6e-34 152.9 Actinobacteria ko:K07076 ko00000 Bacteria 2H951@201174,COG1708@1,COG1708@2 NA|NA|NA S nucleotidyltransferase activity MAG.T1.5_00989 330214.NIDE2247 0.0 1626.7 Nitrospirae dnaE-2 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 3J0FE@40117,COG0587@1,COG0587@2 NA|NA|NA L DNA-directed DNA polymerase MAG.T1.5_00990 330214.NIDE2248 1.2e-168 599.4 Bacteria dinB 2.7.7.7 ko:K02346 ko00000,ko01000,ko03400 Bacteria COG0389@1,COG0389@2 NA|NA|NA L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII MAG.T1.5_00991 330214.NIDE2249 6.3e-75 287.0 Nitrospirae lexA 3.4.21.88 ko:K01356 M00729 ko00000,ko00002,ko01000,ko01002,ko03400 Bacteria 3J1C0@40117,COG1974@1,COG1974@2 NA|NA|NA K Represses a number of genes involved in the response to DNA damage (SOS response) MAG.T1.5_00993 330214.NIDE3985 1.2e-70 272.7 Bacteria Bacteria 2DMP9@1,32SV1@2 NA|NA|NA S Protein of unknown function (DUF3015) MAG.T1.5_00994 330214.NIDE3983 6.1e-187 660.2 Bacteria 2.7.13.3 ko:K07683 ko02020,map02020 M00483 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria COG4585@1,COG4585@2 NA|NA|NA T Histidine kinase MAG.T1.5_00995 330214.NIDE3982 1.3e-108 399.1 Bacteria ko:K02282 ko00000,ko02035,ko02044 Bacteria COG2197@1,COG2197@2 NA|NA|NA K response regulator MAG.T1.5_00997 330214.NIDE3979 3.1e-155 554.7 Nitrospirae Bacteria 3J1C8@40117,COG0500@1,COG2226@2 NA|NA|NA H Dimerisation domain MAG.T1.5_00998 330214.NIDE3978 5.8e-103 380.6 Bacteria ko:K07238 ko00000,ko02000 2.A.5.5 Bacteria COG0428@1,COG0428@2 NA|NA|NA P transporter MAG.T1.5_00999 330214.NIDE3977 1.4e-193 682.2 Bacteria 2.5.1.46 ko:K00809 ko00000,ko01000 Bacteria COG1899@1,COG1899@2 NA|NA|NA O peptidyl-lysine modification to peptidyl-hypusine MAG.T1.5_01000 330214.NIDE3976 3.7e-106 391.0 Bacteria Bacteria COG1651@1,COG1651@2 NA|NA|NA O Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process MAG.T1.5_01002 330214.NIDE3974 1.3e-236 825.5 Nitrospirae 1.2.1.3,1.2.1.9 ko:K00128,ko:K00131 ko00010,ko00030,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130,map01200 M00135,M00308,M00633 R00264,R00631,R00710,R00904,R01058,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0YN@40117,COG1012@1,COG1012@2 NA|NA|NA C Aldehyde dehydrogenase family MAG.T1.5_01003 330214.NIDE3973 2.1e-105 388.3 Bacteria pdaD 4.1.1.19 ko:K02626 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 Bacteria COG1945@1,COG1945@2 NA|NA|NA I arginine decarboxylase activity MAG.T1.5_01004 330214.NIDE3972 2.2e-168 598.2 Bacteria speB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 3.5.3.11 ko:K01480 ko00330,ko01100,map00330,map01100 M00133 R01157 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 Bacteria COG0010@1,COG0010@2 NA|NA|NA E hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines MAG.T1.5_01005 330214.NIDE3971 4.6e-110 404.1 Nitrospirae rluB 5.4.99.19,5.4.99.21,5.4.99.22 ko:K06178,ko:K06182,ko:K06183 ko00000,ko01000,ko03009 Bacteria 3J0RN@40117,COG1187@1,COG1187@2 NA|NA|NA J Belongs to the pseudouridine synthase RsuA family MAG.T1.5_01006 330214.NIDE3970 8.3e-90 336.7 Bacteria VVA0018 Bacteria COG2972@1,COG2972@2 NA|NA|NA T Histidine kinase MAG.T1.5_01008 330214.NIDE3968 4.8e-291 1006.5 Bacteria ko:K02021 ko00000,ko02000 3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21 Bacteria COG2274@1,COG2274@2 NA|NA|NA V protein secretion by the type I secretion system MAG.T1.5_01009 330214.NIDE3967 3.3e-251 874.0 Bacteria Bacteria COG1538@1,COG1538@2 NA|NA|NA MU efflux transmembrane transporter activity MAG.T1.5_01010 330214.NIDE3966 1.5e-240 838.6 Bacteria cvaA Bacteria COG0845@1,COG0845@2 NA|NA|NA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family MAG.T1.5_01011 330214.NIDE3965 9.5e-79 299.7 Nitrospirae purE GO:0003674,GO:0003824,GO:0004638,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0016853,GO:0016866,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034023,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 iETEC_1333.ETEC_0575,iJN746.PP_5336,iPC815.YPO3076,iUTI89_1310.UTI89_C0551 Bacteria 3J0P8@40117,COG0041@1,COG0041@2 NA|NA|NA F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) MAG.T1.5_01012 330214.NIDE3964 5.9e-179 633.6 Nitrospirae purK GO:0000166,GO:0003674,GO:0003824,GO:0004638,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016829,GO:0016830,GO:0016831,GO:0016874,GO:0016879,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034028,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.4.18 ko:K01589 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07404 RC01927 ko00000,ko00001,ko00002,ko01000 iECUMN_1333.ECUMN_0562,iYL1228.KPN_00477 Bacteria 3J11N@40117,COG0026@1,COG0026@2 NA|NA|NA F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) MAG.T1.5_01013 330214.NIDE3963 1.2e-263 915.6 Nitrospirae Bacteria 3J10H@40117,COG0784@1,COG0784@2,COG4191@1,COG4191@2 NA|NA|NA T Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_01014 330214.NIDE3962 1.7e-112 412.1 Nitrospirae Bacteria 3J16E@40117,COG0705@1,COG0705@2 NA|NA|NA S Rhomboid family MAG.T1.5_01015 330214.NIDE3961 1.5e-147 528.9 Nitrospirae nrnB ko:K07097 ko00000 Bacteria 3J12M@40117,COG2404@1,COG2404@2 NA|NA|NA S hydrolase activity, acting on ester bonds MAG.T1.5_01016 330214.NIDE3960 3.8e-185 654.1 Nitrospirae fas6 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 Bacteria 3J169@40117,COG1611@1,COG1611@2 NA|NA|NA S Possible lysine decarboxylase MAG.T1.5_01017 330214.NIDE3959 1.2e-130 472.6 Bacteria 1.1.1.42,1.3.1.85 ko:K00031,ko:K14446 ko00020,ko00480,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00373,M00740 R00267,R00268,R01899,R09291 RC00001,RC00084,RC00114,RC00626,RC02481,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria COG2905@1,COG2905@2 NA|NA|NA T signal-transduction protein containing cAMP-binding and CBS domains MAG.T1.5_01018 330214.NIDE3958 2.5e-190 671.8 Nitrospirae BP2925 ko:K09930 ko00000 Bacteria 3J130@40117,COG3220@1,COG3220@2 NA|NA|NA S Protein of unknown function (DUF692) MAG.T1.5_01019 330214.NIDE3957 9.8e-190 669.5 Bacteria dus ko:K05541 ko00000,ko01000,ko03016 Bacteria COG0042@1,COG0042@2 NA|NA|NA J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines MAG.T1.5_01020 330214.NIDE3956 2.1e-77 295.4 Bacteria maf GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0030312,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0047429,GO:0071944 2.1.1.190 ko:K03215,ko:K06287 ko00000,ko01000,ko03009 Bacteria COG0424@1,COG0424@2 NA|NA|NA D maF-like protein MAG.T1.5_01022 426355.Mrad2831_2561 2.3e-113 416.0 Methylobacteriaceae Bacteria 1JXGR@119045,1QX4P@1224,2V8VU@28211,COG2931@1,COG2931@2 NA|NA|NA Q calcium- and calmodulin-responsive adenylate cyclase activity MAG.T1.5_01023 330214.NIDE3953 1.3e-171 609.0 Bacteria pdhA 1.2.4.1,1.2.4.4 ko:K00161,ko:K11381 ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00036,M00307 R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria COG1071@1,COG1071@2 NA|NA|NA C oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor MAG.T1.5_01024 330214.NIDE3952 2e-164 585.1 Bacteria pdhB 1.2.4.1 ko:K00162,ko:K21417 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2753 Bacteria COG0022@1,COG0022@2 NA|NA|NA C oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor MAG.T1.5_01025 330214.NIDE3951 5.1e-178 630.6 Bacteria pdhC 1.2.4.1,2.3.1.12 ko:K00162,ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R02569,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02857,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria COG0508@1,COG0508@2 NA|NA|NA C S-acyltransferase activity MAG.T1.5_01026 330214.NIDE3950 2.9e-160 571.2 Nitrospirae lipA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 R07767,R07768 RC01978 ko00000,ko00001,ko01000 Bacteria 3J0IY@40117,COG0320@1,COG0320@2 NA|NA|NA H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives MAG.T1.5_01027 1123256.KB907925_gene1399 4e-75 288.5 Xanthomonadales kch 3.6.1.22 ko:K03426,ko:K10716 ko00760,ko01100,ko04146,map00760,map01100,map04146 R00103,R03004,R11104 RC00002 ko00000,ko00001,ko01000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 Bacteria 1MXQP@1224,1SWIH@1236,1XAQW@135614,COG1226@1,COG1226@2 NA|NA|NA P Ion channel MAG.T1.5_01028 330214.NIDE3947 1.3e-246 859.0 Bacteria mscM Bacteria COG0668@1,COG0668@2 NA|NA|NA M transmembrane transport MAG.T1.5_01029 330214.NIDE3944 1.9e-204 718.4 Nitrospirae salY ko:K02004,ko:K05685 ko02010,map02010 M00258,M00709 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.122.1,3.A.1.122.12 Bacteria 3J0EW@40117,COG0577@1,COG0577@2 NA|NA|NA V MacB-like periplasmic core domain MAG.T1.5_01030 330214.NIDE3943 4.9e-182 644.0 Nitrospirae macA_1 ko:K02005,ko:K13888 M00709 ko00000,ko00002,ko02000 8.A.1 Bacteria 3J0HQ@40117,COG0845@1,COG0845@2 NA|NA|NA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family MAG.T1.5_01031 330214.NIDE3942 8.3e-249 865.9 Nitrospirae nla24 ko:K02481,ko:K07713 ko02020,map02020 M00499 ko00000,ko00001,ko00002,ko02022 Bacteria 3J10B@40117,COG2204@1,COG2204@2 NA|NA|NA T Sigma-54 interaction domain MAG.T1.5_01032 330214.NIDE3941 0.0 1298.1 Nitrospirae 2.7.13.3 ko:K02482,ko:K14986 ko02020,map02020 M00524 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 3J124@40117,COG2202@1,COG2202@2,COG3290@1,COG3290@2,COG4191@1,COG4191@2,COG5002@1,COG5002@2 NA|NA|NA T His Kinase A (phosphoacceptor) domain MAG.T1.5_01033 1227349.C170_13100 6.2e-17 94.0 Paenibacillaceae Bacteria 1TS81@1239,26TR8@186822,4HEGD@91061,COG0745@1,COG0745@2 NA|NA|NA T Transcriptional regulator MAG.T1.5_01034 330214.NIDE3939 3.8e-233 813.9 Bacteria Bacteria COG3829@1,COG3829@2 NA|NA|NA T transcription factor binding MAG.T1.5_01035 330214.NIDE3937 0.0 3302.3 Bacteria 1.16.3.3,1.7.2.1 ko:K00368,ko:K07233,ko:K22349 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 Bacteria COG2132@1,COG2132@2 NA|NA|NA Q Multicopper oxidase MAG.T1.5_01036 330214.NIDE3936 4e-170 604.0 Bacteria Bacteria COG3794@1,COG3794@2 NA|NA|NA C PFAM blue (type 1) copper domain protein MAG.T1.5_01037 330214.NIDE3935 3.4e-150 537.7 Nitrospirae Bacteria 3J14J@40117,COG1262@1,COG1262@2 NA|NA|NA S Evidence 4 Homologs of previously reported genes of MAG.T1.5_01038 330214.NIDE3934 7e-170 603.2 Bacteria Bacteria COG1262@1,COG1262@2 NA|NA|NA T PFAM Formylglycine-generating sulfatase enzyme MAG.T1.5_01039 330214.NIDE3933 1.9e-116 425.2 Bacteria crp ko:K01420,ko:K10914,ko:K21556,ko:K21562 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 ko00000,ko00001,ko03000 Bacteria COG0664@1,COG0664@2 NA|NA|NA T cyclic nucleotide binding MAG.T1.5_01041 330214.NIDE3929 1.3e-120 439.1 Bacteria zapB GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0007049,GO:0008150,GO:0009987,GO:0019954,GO:0022402,GO:0022414,GO:0032153,GO:0032505,GO:0042802,GO:0043093,GO:0044424,GO:0044444,GO:0044464,GO:0051301 2.1.1.80,3.1.1.61 ko:K09892,ko:K13924 ko02020,ko02030,map02020,map02030 M00506 ko00000,ko00001,ko00002,ko01000,ko02022,ko02035,ko03036 Bacteria COG3074@1,COG3074@2 NA|NA|NA D FtsZ-dependent cytokinesis MAG.T1.5_01042 330214.NIDE3927 1.4e-57 229.2 Bacteria Bacteria COG5615@1,COG5615@2 NA|NA|NA L integral membrane protein MAG.T1.5_01043 330214.NIDE3926 2.3e-90 338.6 Bacteria 2.7.13.3 ko:K07711 ko02020,ko02024,map02020,map02024 M00502 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria COG5278@1,COG5278@2 NA|NA|NA T phosphoserine phosphatase activity MAG.T1.5_01044 330214.NIDE3925 4.3e-236 823.5 Nitrospirae sqr GO:0003674,GO:0003824,GO:0003955,GO:0005488,GO:0005515,GO:0006091,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0019646,GO:0022900,GO:0022904,GO:0042802,GO:0044237,GO:0045333,GO:0055114 1.8.5.4 ko:K17218 ko00920,map00920 R10152 RC03155 ko00000,ko00001,ko01000 Bacteria 3J102@40117,COG0446@1,COG0446@2 NA|NA|NA C Pyridine nucleotide-disulphide oxidoreductase MAG.T1.5_01045 330214.NIDE3920 5.7e-133 480.3 Bacteria ko:K07090 ko00000 Bacteria COG0730@1,COG0730@2 NA|NA|NA S response to heat MAG.T1.5_01046 330214.NIDE3919 8e-172 609.8 Bacteria Bacteria 2FARP@1,342Z3@2 NA|NA|NA MAG.T1.5_01047 1268239.PALB_1730 2.6e-12 77.4 Pseudoalteromonadaceae Bacteria 1N6NN@1224,1SCRA@1236,2Q3DA@267888,32YCZ@2,COG0607@1 NA|NA|NA P COG0607 Rhodanese-related sulfurtransferase MAG.T1.5_01048 330214.NIDE3917 1.4e-137 496.1 Nitrospirae Bacteria 3J13X@40117,COG0845@1,COG0845@2 NA|NA|NA M HlyD family secretion protein MAG.T1.5_01049 330214.NIDE3916 0.0 1760.3 Nitrospirae Bacteria 3J0VZ@40117,COG0841@1,COG0841@2 NA|NA|NA V AcrB/AcrD/AcrF family MAG.T1.5_01050 330214.NIDE1927 1.3e-32 147.1 Nitrospirae mntH ko:K03322 ko00000,ko02000 2.A.55.2.6,2.A.55.3 Bacteria 3J1A7@40117,COG0589@1,COG0589@2 NA|NA|NA T Belongs to the universal stress protein A family MAG.T1.5_01051 987059.RBXJA2T_13976 1.5e-49 203.4 Betaproteobacteria uspA Bacteria 1PE08@1224,2VNHV@28216,COG0589@1,COG0589@2 NA|NA|NA T universal stress protein MAG.T1.5_01052 686340.Metal_1712 0.0 1115.1 Methylococcales ctpF Bacteria 1MUU5@1224,1RMYC@1236,1XDXD@135618,COG0474@1,COG0474@2 NA|NA|NA P TIGRFAM ATPase, P-type, K Mg Cd Cu Zn Na Ca Na H-transporter MAG.T1.5_01053 330214.NIDE0872 8.6e-198 696.8 Nitrospirae ko:K03455 ko00000 2.A.37 Bacteria 3J12F@40117,COG0475@1,COG0475@2,COG1226@1,COG1226@2 NA|NA|NA P TrkA-N domain MAG.T1.5_01054 1294143.H681_09730 1.6e-74 285.8 Gammaproteobacteria Bacteria 1MWF7@1224,1RPZ6@1236,COG1309@1,COG1309@2 NA|NA|NA D Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions MAG.T1.5_01055 330214.NIDE3915 1.8e-211 741.9 Nitrospirae Bacteria 3J19C@40117,COG1538@1,COG1538@2 NA|NA|NA MU Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_01056 1304885.AUEY01000027_gene2343 3.8e-74 285.4 Desulfobacterales ybhG ko:K01993,ko:K02005 ko00000 Bacteria 1QU7Z@1224,2MPNH@213118,2X70W@28221,43BPM@68525,COG1566@1,COG1566@2 NA|NA|NA V Barrel-sandwich domain of CusB or HlyD membrane-fusion MAG.T1.5_01057 269799.Gmet_0658 6.6e-120 437.2 Deltaproteobacteria ybhF-N ko:K01990,ko:K13926 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1MUX3@1224,2WKFC@28221,42PIB@68525,COG1131@1,COG1131@2 NA|NA|NA V Abc transporter MAG.T1.5_01058 269799.Gmet_0657 2e-132 478.8 Deltaproteobacteria ybhF-C ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1MUX3@1224,2WK9W@28221,42MV1@68525,COG1131@1,COG1131@2 NA|NA|NA V PFAM ABC transporter MAG.T1.5_01059 247490.KSU1_D0847 1.6e-133 482.6 Planctomycetes ybhS ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2J1QC@203682,COG0842@1,COG0842@2 NA|NA|NA V ABC-2 family transporter protein MAG.T1.5_01060 237368.SCABRO_02469 1.3e-143 516.2 Planctomycetes ybhR ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2IYZA@203682,COG0842@1,COG0842@2 NA|NA|NA V ABC-2 type transporter MAG.T1.5_01061 330214.NIDE3910 1.1e-95 356.7 Nitrospirae GO:0003674,GO:0003824,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0009987,GO:0010333,GO:0016829,GO:0016835,GO:0016838,GO:0042214,GO:0044237,GO:0044238,GO:0044255,GO:0071704 4.2.3.118 ko:K16218 ko00000,ko01000 Bacteria 3J1CW@40117,COG3170@1,COG3170@2 NA|NA|NA NU Protein of unknown function (DUF1207) MAG.T1.5_01062 330214.NIDE3923 3e-57 228.0 Bacteria Bacteria 2ED3M@1,3370H@2 NA|NA|NA MAG.T1.5_01064 330214.NIDE3921 4.6e-112 411.0 Bacteria Bacteria 29TFP@1,30ENV@2 NA|NA|NA MAG.T1.5_01065 330214.NIDE3914 2.2e-54 218.0 Bacteria Bacteria COG0662@1,COG0662@2 NA|NA|NA G Cupin 2, conserved barrel domain protein MAG.T1.5_01066 330214.NIDE3913 2.2e-235 821.6 Bacteria Bacteria COG1807@1,COG1807@2 NA|NA|NA M 4-amino-4-deoxy-L-arabinose transferase activity MAG.T1.5_01067 330214.NIDE3912 9e-61 239.6 Bacteria Bacteria COG4244@1,COG4244@2 NA|NA|NA E Membrane MAG.T1.5_01068 330214.NIDE3911 3.4e-78 298.9 Bacteria Bacteria COG1664@1,COG1664@2 NA|NA|NA M Polymer-forming cytoskeletal MAG.T1.5_01069 330214.NIDE3909 3.7e-154 551.2 Bacteria iamB ko:K02066 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria COG0767@1,COG0767@2 NA|NA|NA Q ABC-type transport system involved in resistance to organic solvents, permease component MAG.T1.5_01071 330214.NIDE3908 3.2e-120 438.0 Nitrospirae iamA ko:K02065 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 3J0J2@40117,COG1127@1,COG1127@2 NA|NA|NA Q ABC transporter MAG.T1.5_01072 330214.NIDE3907 3.8e-123 448.0 Bacteria iamC ko:K02067 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria COG1463@1,COG1463@2 NA|NA|NA Q ABC-type transport system involved in resistance to organic solvents, periplasmic component MAG.T1.5_01073 330214.NIDE3906 2.3e-68 265.4 Bacteria ko:K18480 M00669 ko00000,ko00002,ko02000 3.A.1.27.1 Bacteria COG3218@1,COG3218@2 NA|NA|NA Q ABC-type transport auxiliary lipoprotein component MAG.T1.5_01074 330214.NIDE3905 1.5e-64 252.3 Bacteria Bacteria COG1814@1,COG1814@2 NA|NA|NA S cellular manganese ion homeostasis MAG.T1.5_01075 330214.NIDE3904 2.3e-221 774.6 Nitrospirae treT 2.4.1.245 ko:K13057 ko00500,ko01100,map00500,map01100 R08946,R10525,R11306 RC00005,RC00049,RC02748 ko00000,ko00001,ko01000 GT4 Bacteria 3J0Z0@40117,COG0438@1,COG0438@2 NA|NA|NA M Glycosyl transferases group 1 MAG.T1.5_01076 330214.NIDE3903 7.8e-305 1052.4 Nitrospirae glgP 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 R02111 ko00000,ko00001,ko01000 GT35 Bacteria 3J0W1@40117,COG0058@1,COG0058@2 NA|NA|NA G Carbohydrate phosphorylase MAG.T1.5_01079 330214.NIDE3821 1.3e-51 210.3 Bacteria manC 2.7.7.13,5.3.1.8 ko:K00971,ko:K16011 ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025 M00114,M00361,M00362 R00885,R01819 RC00002,RC00376 ko00000,ko00001,ko00002,ko01000 Bacteria COG0836@1,COG0836@2 NA|NA|NA M mannose-1-phosphate guanylyltransferase activity MAG.T1.5_01080 330214.NIDE3897 1.9e-138 498.8 Nitrospirae mntH ko:K03322 ko00000,ko02000 2.A.55.2.6,2.A.55.3 Bacteria 3J1A7@40117,COG0589@1,COG0589@2 NA|NA|NA T Belongs to the universal stress protein A family MAG.T1.5_01081 330214.NIDE3896 3.8e-64 250.8 Bacteria rnk ko:K03624,ko:K06140 ko00000,ko03000,ko03021 Bacteria COG0782@1,COG0782@2 NA|NA|NA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus MAG.T1.5_01082 330214.NIDE3895 1.8e-64 251.9 Bacteria ymaD ko:K04063 ko00000 Bacteria COG1764@1,COG1764@2 NA|NA|NA O response to oxidative stress MAG.T1.5_01083 330214.NIDE3893 2.9e-31 141.4 Bacteria ko:K12263 ko00000 Bacteria COG2010@1,COG2010@2 NA|NA|NA C Cytochrome c MAG.T1.5_01084 330214.NIDE3892 2.1e-66 258.5 Bacteria Bacteria 2ED3M@1,3370H@2 NA|NA|NA MAG.T1.5_01085 665571.STHERM_c01710 3e-07 60.8 Bacteria Bacteria 2EGD6@1,33A4Z@2 NA|NA|NA S Protein of unknown function (DUF2892) MAG.T1.5_01086 330214.NIDE3231 9.4e-37 159.8 Bacteria ko:K09137 ko00000 Bacteria COG0517@1,COG0517@2 NA|NA|NA S IMP dehydrogenase activity MAG.T1.5_01087 330214.NIDE3890 3.1e-77 294.7 Nitrospirae 1.3.5.1,1.3.5.4 ko:K00240,ko:K03886 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00151,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0TT@40117,COG0723@1,COG0723@2 NA|NA|NA C Rieske [2Fe-2S] domain MAG.T1.5_01088 330214.NIDE3889 3e-240 837.4 Nitrospirae qcrC ko:K00412,ko:K03888 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 ko00000,ko00001,ko00002,ko03029 Bacteria 3J0Q6@40117,COG1290@1,COG1290@2,COG2010@1,COG2010@2 NA|NA|NA C Cytochrome b/b6/petB MAG.T1.5_01089 330214.NIDE3882 5.4e-23 114.8 Bacteria ko:K12263 ko00000 Bacteria COG2010@1,COG2010@2 NA|NA|NA C Cytochrome c MAG.T1.5_01090 330214.NIDE3888 8.1e-42 176.4 Bacteria ko:K12263 ko00000 Bacteria COG2010@1,COG2010@2 NA|NA|NA C Cytochrome c MAG.T1.5_01091 330214.NIDE3887 4.4e-90 337.4 Bacteria Bacteria COG0840@1,COG0840@2 NA|NA|NA NT transmembrane signaling receptor activity MAG.T1.5_01094 749222.Nitsa_0554 5.5e-61 241.9 Epsilonproteobacteria chrA ko:K07240 ko00000,ko02000 2.A.51.1 Bacteria 1MUBW@1224,2YT01@29547,42QCN@68525,COG2059@1,COG2059@2 NA|NA|NA P TIGRFAM chromate transporter, chromate ion transporter (CHR) family MAG.T1.5_01095 314345.SPV1_01867 2.3e-12 79.0 Proteobacteria Bacteria 1NAXP@1224,2DP44@1,330FI@2 NA|NA|NA S Cytochrome C' MAG.T1.5_01096 323261.Noc_0532 4.9e-34 151.0 Chromatiales yhjR 2.7.7.87 ko:K07566 R10463 RC00745 ko00000,ko01000,ko03009,ko03016 Bacteria 1QW29@1224,1S7N1@1236,1X10I@135613,COG4902@1,COG4902@2 NA|NA|NA MAG.T1.5_01097 56780.SYN_01164 7e-136 490.3 Deltaproteobacteria hisD 1.1.1.23,2.6.1.9 ko:K00013,ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R01158,R01163,R03012,R03243 RC00006,RC00099,RC00242,RC00463,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 1MW7I@1224,2WJDR@28221,42NCH@68525,COG0079@1,COG0079@2 NA|NA|NA E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily MAG.T1.5_01098 330214.NIDE0670 6.5e-48 197.2 Bacteria Bacteria 2BVVW@1,32175@2 NA|NA|NA S Cytochrome P460 MAG.T1.5_01099 330214.NIDE4060 2.4e-158 565.1 Nitrospirae mauG GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.11.1.5 ko:K00428 ko00000,ko01000 Bacteria 3J0GH@40117,COG1858@1,COG1858@2 NA|NA|NA C Di-haem cytochrome c peroxidase MAG.T1.5_01100 404589.Anae109_3615 3.3e-85 321.6 delta/epsilon subdivisions peb3 ko:K10938 ko05111,map05111 ko00000,ko00001 Bacteria 1N6UH@1224,42Q91@68525,COG4588@1,COG4588@2 NA|NA|NA S Bacterial extracellular solute-binding protein MAG.T1.5_01101 671143.DAMO_1951 1.9e-27 129.4 Bacteria Bacteria COG3678@1,COG3678@2 NA|NA|NA NPTU ATP-independent chaperone mediated protein folding MAG.T1.5_01102 395494.Galf_2194 3.9e-41 174.9 Nitrosomonadales Bacteria 1QUPT@1224,2WCP5@28216,44WF7@713636,COG1472@1,COG1472@2 NA|NA|NA G Protein of unknown function (DUF3365) MAG.T1.5_01104 472759.Nhal_2109 1.7e-88 332.4 Chromatiales ko:K07238,ko:K11021 ko00000,ko02000,ko02042 2.A.5.5 Bacteria 1PMN6@1224,1SIQH@1236,1X1XX@135613,COG0428@1,COG0428@2 NA|NA|NA P ZIP Zinc transporter MAG.T1.5_01105 1121957.ATVL01000011_gene3721 1.9e-15 88.6 Cytophagia Bacteria 2DJ8B@1,32UCJ@2,47RZN@768503,4NTR0@976 NA|NA|NA MAG.T1.5_01106 693661.Arcve_0310 2.6e-53 215.7 Archaeoglobi gufA ko:K07238 ko00000,ko02000 2.A.5.5 Archaea 246ZF@183980,2XXNC@28890,COG0428@1,arCOG00576@2157 NA|NA|NA P PFAM zinc iron permease MAG.T1.5_01107 330214.NIDE3936 3.5e-97 361.7 Bacteria Bacteria COG3794@1,COG3794@2 NA|NA|NA C PFAM blue (type 1) copper domain protein MAG.T1.5_01108 330214.NIDE3864 4.1e-30 137.5 Nitrospirae ko:K12263 ko00000 Bacteria 3J1AX@40117,COG2010@1,COG2010@2 NA|NA|NA C Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_01109 330214.NIDE3886 7.6e-144 516.5 Nitrospirae tsdA GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0016667,GO:0016669,GO:0022900,GO:0042597,GO:0044237,GO:0044464,GO:0050338,GO:0055114 1.8.2.2 ko:K19713 ko00000,ko01000 Bacteria 3J12T@40117,COG3258@1,COG3258@2 NA|NA|NA C Cytochrome C oxidase, cbb3-type, subunit III MAG.T1.5_01110 330214.NIDE3885 2.6e-62 244.6 Bacteria ycaO ko:K09136 ko00000,ko03009 Bacteria COG1765@1,COG1765@2 NA|NA|NA O OsmC-like protein MAG.T1.5_01111 330214.NIDE3884 1.2e-190 672.5 Bacteria sorA ko:K07147 ko00000,ko01000 Bacteria COG2041@1,COG2041@2 NA|NA|NA V Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide MAG.T1.5_01112 330214.NIDE3883 4.3e-91 340.9 Bacteria ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 ko00000,ko00001,ko00002 3.D.4.3 Bacteria COG2010@1,COG2010@2 NA|NA|NA C Cytochrome c MAG.T1.5_01113 330214.NIDE3882 8e-207 726.5 Bacteria ko:K12263 ko00000 Bacteria COG2010@1,COG2010@2 NA|NA|NA C Cytochrome c MAG.T1.5_01114 330214.NIDE3881 8.1e-55 219.5 Bacteria ko:K06039,ko:K07235 ko04122,map04122 ko00000,ko00001,ko01000,ko03016 Bacteria COG1553@1,COG1553@2 NA|NA|NA P Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE MAG.T1.5_01115 330214.NIDE3880 1.3e-166 592.4 Bacteria 2.7.4.1 ko:K22468 ko00190,ko03018,map00190,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria COG2326@1,COG2326@2 NA|NA|NA S polyphosphate kinase activity MAG.T1.5_01117 671143.DAMO_1955 9.3e-23 112.8 Bacteria Bacteria 2E5GP@1,3308B@2 NA|NA|NA MAG.T1.5_01118 671143.DAMO_1956 2.5e-159 568.5 Bacteria ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria COG4591@1,COG4591@2 NA|NA|NA M lipoprotein localization to outer membrane MAG.T1.5_01119 671143.DAMO_1957 2.2e-90 338.6 unclassified Bacteria ko:K02003 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 2NP53@2323,COG1136@1,COG1136@2 NA|NA|NA V ABC transporter MAG.T1.5_01120 671143.DAMO_1958 9.9e-135 486.5 Bacteria Bacteria 28K4S@1,2Z9TM@2 NA|NA|NA MAG.T1.5_01121 671143.DAMO_1959 2.9e-53 214.9 Bacteria Bacteria COG4314@1,COG4314@2 NA|NA|NA C lipoprotein involved in nitrous oxide reduction MAG.T1.5_01122 443143.GM18_4120 3.3e-22 111.7 Deltaproteobacteria tlpA Bacteria 1Q3FH@1224,2WRZR@28221,43A8D@68525,COG0526@1,COG0526@2 NA|NA|NA O PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen MAG.T1.5_01124 671143.DAMO_1960 3.8e-188 664.5 Bacteria ko:K21601 ko00000,ko03000 Bacteria COG4314@1,COG4314@2 NA|NA|NA C lipoprotein involved in nitrous oxide reduction MAG.T1.5_01125 330214.NIDE3879 7.1e-50 203.8 Nitrospirae Bacteria 3J17C@40117,COG2010@1,COG2010@2 NA|NA|NA C Cytochrome C oxidase, cbb3-type, subunit III MAG.T1.5_01126 330214.NIDE3877 1.8e-72 278.5 Bacteria trxC 1.8.1.8 ko:K03672 ko00000,ko01000,ko03110 Bacteria COG3118@1,COG3118@2 NA|NA|NA O belongs to the thioredoxin family MAG.T1.5_01127 330214.NIDE3876 2.2e-32 144.8 Nitrospirae XK27_07760 Bacteria 3J1B3@40117,COG4980@1,COG4980@2 NA|NA|NA S Evidence 4 Homologs of previously reported genes of MAG.T1.5_01128 330214.NIDE3875 7.3e-108 397.1 Nitrospirae porD 1.2.1.58,1.2.7.1 ko:K00171,ko:K00172,ko:K18357,ko:K18358 ko00010,ko00020,ko00360,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00360,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R02450,R08034 RC00004,RC00250,RC02742,RC02833,RC02860 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 3J0TG@40117,COG1014@1,COG1014@2,COG1144@1,COG1144@2 NA|NA|NA C Pyruvate ferredoxin/flavodoxin oxidoreductase MAG.T1.5_01129 330214.NIDE3874 3e-205 721.1 Nitrospirae porA GO:0003674,GO:0003824,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:1901575 1.2.7.1,1.2.7.10 ko:K00169,ko:K19070 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 3J0HY@40117,COG0674@1,COG0674@2 NA|NA|NA C Pyruvate:ferredoxin oxidoreductase core domain II MAG.T1.5_01130 330214.NIDE3873 6.1e-163 580.1 Nitrospirae 1.2.7.1 ko:K00170 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 3J0KG@40117,COG1013@1,COG1013@2 NA|NA|NA C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain MAG.T1.5_01131 314345.SPV1_01867 2.3e-07 62.4 Proteobacteria Bacteria 1NAXP@1224,2DP44@1,330FI@2 NA|NA|NA S Cytochrome C' MAG.T1.5_01132 330214.NIDE3871 2.4e-78 298.1 Bacteria Bacteria COG5592@1,COG5592@2 NA|NA|NA I hemerythrin HHE cation binding domain MAG.T1.5_01134 330214.NIDE3869 2.7e-79 301.6 Bacteria Bacteria 296YQ@1,2ZU7A@2 NA|NA|NA MAG.T1.5_01135 1123257.AUFV01000026_gene4 9.7e-07 60.5 Xanthomonadales cbcC Bacteria 1QZ6I@1224,1RXZD@1236,1X8R4@135614,COG3005@1,COG3005@2 NA|NA|NA C denitrification pathway MAG.T1.5_01137 1116472.MGMO_118c00020 9.4e-25 119.4 Gammaproteobacteria Bacteria 1N9U3@1224,1SSRU@1236,COG5304@1,COG5304@2 NA|NA|NA MAG.T1.5_01138 330214.NIDE3866 0.0 1508.0 Nitrospirae yfiQ GO:0003674,GO:0003824,GO:0006464,GO:0006473,GO:0006475,GO:0006807,GO:0006950,GO:0006979,GO:0008080,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0018193,GO:0018205,GO:0018393,GO:0018394,GO:0019538,GO:0022607,GO:0032459,GO:0032462,GO:0034212,GO:0036211,GO:0043170,GO:0043254,GO:0043412,GO:0043543,GO:0043933,GO:0044085,GO:0044087,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0052858,GO:0061733,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:1901564 6.2.1.13 ko:K01905,ko:K09181,ko:K22224 ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120 R00229,R00920 RC00004,RC00012,RC00014 ko00000,ko00001,ko01000,ko01004 Bacteria 3J0ZI@40117,COG0045@1,COG0045@2,COG1042@1,COG1042@2,COG1670@1,COG1670@2 NA|NA|NA C ATP-grasp domain MAG.T1.5_01139 330214.NIDE3865 1.8e-135 489.2 Bacteria Bacteria COG0695@1,COG0695@2 NA|NA|NA O Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins MAG.T1.5_01140 330214.NIDE3864 1.8e-57 228.4 Nitrospirae ko:K12263 ko00000 Bacteria 3J1AX@40117,COG2010@1,COG2010@2 NA|NA|NA C Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_01141 330214.NIDE3863 2.9e-143 514.6 Bacteria Bacteria COG0589@1,COG0589@2 NA|NA|NA T AMP binding MAG.T1.5_01143 330214.NIDE3861 8.9e-76 289.7 Bacteria Bacteria COG1499@1,COG1499@2 NA|NA|NA J amine dehydrogenase activity MAG.T1.5_01144 330214.NIDE3860 9.8e-99 366.3 Nitrospirae prsT ko:K07100 ko00000 Bacteria 3J18T@40117,COG1926@1,COG1926@2 NA|NA|NA S Phosphoribosyl transferase domain MAG.T1.5_01146 330214.NIDE3859 5.5e-75 287.0 Nitrospirae ibpA ko:K13993 ko04141,map04141 ko00000,ko00001,ko03110 Bacteria 3J0TV@40117,COG0071@1,COG0071@2 NA|NA|NA O Belongs to the small heat shock protein (HSP20) family MAG.T1.5_01147 330214.NIDE3856 2.3e-111 408.3 Bacteria ko:K07074 ko00000 Bacteria COG3541@1,COG3541@2 NA|NA|NA L Predicted nucleotidyltransferase MAG.T1.5_01148 330214.NIDE3855 3.2e-29 134.0 Bacteria Bacteria COG0236@1,COG0236@2 NA|NA|NA IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis MAG.T1.5_01149 330214.NIDE3854 4e-159 567.8 Bacteria aceF 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria COG0508@1,COG0508@2 NA|NA|NA C S-acyltransferase activity MAG.T1.5_01150 330214.NIDE3853 1.3e-158 565.8 Bacteria pdhA 1.2.4.1,1.2.4.4 ko:K00162,ko:K11381 ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00036,M00307 R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria COG0022@1,COG0022@2 NA|NA|NA C oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor MAG.T1.5_01151 330214.NIDE3852 7e-144 516.9 Bacteria pdhA 1.2.4.1,1.2.4.4 ko:K00161,ko:K00162,ko:K11381,ko:K21416 ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00036,M00307 R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria COG1071@1,COG1071@2 NA|NA|NA C oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor MAG.T1.5_01152 330214.NIDE3851 5e-299 1033.1 Nitrospirae acsA 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 3J0BJ@40117,COG0365@1,COG0365@2 NA|NA|NA I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA MAG.T1.5_01153 330214.NIDE3850 3.6e-196 691.0 Bacteria cpgS ko:K05716 R03298 RC00900 ko00000,ko01000 Bacteria COG2403@1,COG2403@2 NA|NA|NA S cyclic 2,3-diphosphoglycerate synthetase activity MAG.T1.5_01155 330214.NIDE3848 8.3e-133 479.9 Bacteria 2.7.11.1,3.4.21.107 ko:K04771,ko:K14949 ko01503,ko02020,ko05152,map01503,map02020,map05152 M00728 ko00000,ko00001,ko00002,ko01000,ko01001,ko01002,ko03110 Bacteria COG0265@1,COG0265@2 NA|NA|NA O serine-type endopeptidase activity MAG.T1.5_01157 330214.NIDE3847 1.9e-282 978.0 Bacteria polX ko:K02347,ko:K04477 ko00000,ko03400 Bacteria COG1387@1,COG1387@2,COG1796@1,COG1796@2 NA|NA|NA L DNA-directed DNA polymerase activity MAG.T1.5_01158 330214.NIDE3846 7.4e-234 816.2 Nitrospirae mez_1 1.1.1.38 ko:K00027 ko00620,ko01200,ko02020,map00620,map01200,map02020 R00214 RC00105 ko00000,ko00001,ko01000 Bacteria 3J0WV@40117,COG0281@1,COG0281@2 NA|NA|NA C Malic enzyme, NAD binding domain MAG.T1.5_01159 330214.NIDE3842 4.8e-51 206.8 Bacteria higA ko:K21498 ko00000,ko02048 Bacteria COG3093@1,COG3093@2 NA|NA|NA K addiction module antidote protein HigA MAG.T1.5_01162 768706.Desor_4304 2.4e-305 1055.4 Peptococcaceae lidB 3.6.4.12 ko:K03654 ko03018,map03018 ko00000,ko00001,ko01000,ko03400 Bacteria 1TP20@1239,24BMH@186801,263S0@186807,COG0210@1,COG0210@2,COG1112@1,COG1112@2,COG2852@1,COG2852@2 NA|NA|NA L AAA domain MAG.T1.5_01163 330214.NIDE3838 1.4e-137 495.7 Bacteria Bacteria COG0589@1,COG0589@2 NA|NA|NA T AMP binding MAG.T1.5_01166 768671.ThimaDRAFT_3585 7.5e-29 134.0 Chromatiales cas3 ko:K07012 ko00000,ko01000,ko02048 Bacteria 1R8FD@1224,1RZN1@1236,1WX9Y@135613,COG1203@1,COG1203@2,COG3177@1,COG3177@2 NA|NA|NA L CRISPR-associated helicase, Cas3 MAG.T1.5_01167 1268635.Loa_01452 8.1e-52 211.1 Legionellales Bacteria 1JC64@118969,1N5CH@1224,1SFFE@1236,COG4313@1,COG4313@2 NA|NA|NA C Protein involved in meta-pathway of phenol degradation MAG.T1.5_01168 330214.NIDE3827 2.6e-75 288.5 Nitrospirae ko:K07323 ko02010,map02010 M00210 ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 Bacteria 3J13Z@40117,COG2854@1,COG2854@2 NA|NA|NA Q Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_01169 330214.NIDE3826 0.0 2496.5 Nitrospirae Bacteria 3J0XX@40117,COG1924@1,COG1924@2,COG3580@1,COG3580@2,COG3581@1,COG3581@2 NA|NA|NA I CoA enzyme activase uncharacterised domain (DUF2229) MAG.T1.5_01170 330214.NIDE3825 3.6e-96 357.8 Bacteria ko:K07337 ko00000 Bacteria COG3417@1,COG3417@2 NA|NA|NA M Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) MAG.T1.5_01171 330214.NIDE3823 4.5e-129 467.6 Bacteria ddh 1.4.1.16 ko:K03340 ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230 M00526 R02755 RC00006 ko00000,ko00001,ko00002,ko01000 Bacteria COG1748@1,COG1748@2 NA|NA|NA E saccharopine dehydrogenase activity MAG.T1.5_01173 330214.NIDE3822 5.4e-67 260.4 Bacteria ybcL ko:K06910 ko00000 Bacteria COG1881@1,COG1881@2 NA|NA|NA S positive regulation of acetylcholine metabolic process MAG.T1.5_01174 330214.NIDE3819 1e-123 449.9 Bacteria ko:K07282 ko00000 Bacteria COG2843@1,COG2843@2 NA|NA|NA M Bacterial capsule synthesis protein PGA_cap MAG.T1.5_01175 330214.NIDE3818 2.4e-48 198.4 Bacteria soxX ko:K02305,ko:K17223 ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120 M00529,M00595 R00294,R10151 RC02794,RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.10 Bacteria COG2010@1,COG2010@2 NA|NA|NA C Cytochrome c MAG.T1.5_01177 330214.NIDE3247 3.2e-52 211.8 Bacteria ko:K02282 ko00000,ko02035,ko02044 Bacteria COG2197@1,COG2197@2 NA|NA|NA K response regulator MAG.T1.5_01178 330214.NIDE3813 2e-264 918.3 Bacteria Bacteria COG4625@1,COG4625@2 NA|NA|NA T pathogenesis MAG.T1.5_01179 330214.NIDE1877 3.8e-42 178.7 Bacteria Bacteria COG2931@1,COG2931@2 NA|NA|NA Q calcium- and calmodulin-responsive adenylate cyclase activity MAG.T1.5_01180 330214.NIDE3812 2e-132 479.9 Nitrospirae Bacteria 3J17M@40117,COG0457@1,COG0457@2 NA|NA|NA S Evidence 4 Homologs of previously reported genes of MAG.T1.5_01181 330214.NIDE3811 4.5e-230 803.9 Nitrospirae epsH Bacteria 3J156@40117,COG1269@1,COG1269@2 NA|NA|NA C Evidence 4 Homologs of previously reported genes of MAG.T1.5_01182 330214.NIDE3810 1.4e-164 585.9 Bacteria celD Bacteria COG5653@1,COG5653@2 NA|NA|NA M Protein involved in cellulose biosynthesis MAG.T1.5_01183 330214.NIDE3809 5.1e-131 474.2 Bacteria walW Bacteria COG0726@1,COG0726@2 NA|NA|NA G polysaccharide deacetylase MAG.T1.5_01186 330214.NIDE3808 9.9e-145 519.6 Nitrospirae ko:K07033 ko00000 Bacteria 3J1E6@40117,COG0719@1,COG0719@2 NA|NA|NA O Uncharacterized protein family (UPF0051) MAG.T1.5_01187 330214.NIDE3807 4.5e-111 407.5 Nitrospirae sufC ko:K09013 ko00000,ko02000 Bacteria 3J19D@40117,COG0396@1,COG0396@2 NA|NA|NA O ABC transporter MAG.T1.5_01190 330214.NIDE3804 3.3e-107 394.4 Bacteria ko:K08984 ko00000 Bacteria COG3647@1,COG3647@2 NA|NA|NA S Membrane MAG.T1.5_01191 330214.NIDE3803 1.6e-77 295.8 Bacteria yjdF ko:K08984 ko00000 Bacteria COG3647@1,COG3647@2 NA|NA|NA S Membrane MAG.T1.5_01193 330214.NIDE3799 3.2e-93 347.8 Bacteria Bacteria COG2249@1,COG2249@2 NA|NA|NA K NAD(P)H dehydrogenase (quinone) activity MAG.T1.5_01194 658187.LDG_7972 5e-15 88.2 Legionellales Bacteria 1JG04@118969,1QC8C@1224,1T7XR@1236,2BVT5@1,347S4@2 NA|NA|NA MAG.T1.5_01196 929703.KE386491_gene3992 1e-22 114.0 Cytophagia lpxD GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 ic_1306.c0216 Bacteria 47RE1@768503,4NT1W@976,COG1044@1,COG1044@2 NA|NA|NA M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell MAG.T1.5_01197 330214.NIDE3796 1e-166 592.8 Nitrospirae 2.1.1.302 ko:K21377 ko00000,ko01000 Bacteria 3J1C8@40117,COG0500@1,COG2226@2 NA|NA|NA H Dimerisation domain MAG.T1.5_01198 330214.NIDE3794 8.3e-146 523.1 Bacteria Bacteria COG3794@1,COG3794@2 NA|NA|NA C PFAM blue (type 1) copper domain protein MAG.T1.5_01199 330214.NIDE3793 9.8e-256 889.0 Nitrospirae Bacteria 29W26@1,30HKR@2,3J1BV@40117 NA|NA|NA MAG.T1.5_01201 330214.NIDE3791 2.3e-126 458.4 Bacteria ko:K16129 ko01054,map01054 ko00000,ko00001,ko01008 Bacteria COG0500@1,COG2226@2 NA|NA|NA Q methyltransferase MAG.T1.5_01203 1295642.H839_07284 1.8e-69 270.4 Geobacillus phoD 3.1.3.1,3.1.4.46 ko:K01113,ko:K01126 ko00564,ko00790,ko01100,ko02020,map00564,map00790,map01100,map02020 M00126 R01030,R01470,R04620 RC00017,RC00425 ko00000,ko00001,ko00002,ko01000 Bacteria 1UGF1@1239,1WG8A@129337,4H9QE@91061,COG0584@1,COG0584@2,COG3540@1,COG3540@2 NA|NA|NA C Glycerophosphoryl diester phosphodiesterase family MAG.T1.5_01205 345341.KUTG_00490 1.1e-55 224.6 Pseudonocardiales Bacteria 2GJZH@201174,4EAUR@85010,COG5607@1,COG5607@2 NA|NA|NA S CYTH MAG.T1.5_01206 330214.NIDE3790 1e-115 422.9 Bacteria ygdQ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria COG0861@1,COG0861@2 NA|NA|NA P Integral membrane protein TerC family MAG.T1.5_01207 330214.NIDE3787 3.6e-138 497.7 Bacteria ko:K10716 ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 Bacteria COG2905@1,COG2905@2 NA|NA|NA T signal-transduction protein containing cAMP-binding and CBS domains MAG.T1.5_01208 330214.NIDE3786 0.0 1540.0 Nitrospirae pacL 3.6.3.8,3.6.3.9 ko:K01537,ko:K01539 ko04022,ko04024,ko04260,ko04261,ko04911,ko04918,ko04919,ko04925,ko04960,ko04961,ko04964,ko04970,ko04971,ko04972,ko04973,ko04974,ko04976,ko04978,map04022,map04024,map04260,map04261,map04911,map04918,map04919,map04925,map04960,map04961,map04964,map04970,map04971,map04972,map04973,map04974,map04976,map04978 ko00000,ko00001,ko01000,ko04147 3.A.3.1,3.A.3.2 Bacteria 3J0WH@40117,COG0474@1,COG0474@2 NA|NA|NA P Cation transporter/ATPase, N-terminus MAG.T1.5_01209 330214.NIDE3785 2.4e-135 488.4 Bacteria Bacteria COG0589@1,COG0589@2 NA|NA|NA T AMP binding MAG.T1.5_01210 1249627.D779_0535 3.9e-08 65.1 Chromatiales Bacteria 1N6V1@1224,1SETV@1236,1X14M@135613,2C5P4@1,3310H@2 NA|NA|NA MAG.T1.5_01211 330214.NIDE3783 3.1e-46 191.4 Bacteria ko:K07182 ko00000 Bacteria COG0517@1,COG0517@2 NA|NA|NA S IMP dehydrogenase activity MAG.T1.5_01212 330214.NIDE3782 5.6e-66 256.9 Bacteria ko:K07182 ko00000 Bacteria COG0517@1,COG0517@2 NA|NA|NA S IMP dehydrogenase activity MAG.T1.5_01213 330214.NIDE3781 2.8e-162 578.2 Nitrospirae yajR_1 Bacteria 3J0VR@40117,COG0477@1,COG2814@2 NA|NA|NA EGP Major Facilitator Superfamily MAG.T1.5_01215 330214.NIDE3778 3.8e-26 126.3 Nitrospirae Bacteria 3J1CA@40117,COG1357@1,COG1357@2 NA|NA|NA S Pentapeptide repeats (9 copies) MAG.T1.5_01216 330214.NIDE3777 7.9e-196 689.9 Bacteria pncB GO:0001666,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0034355,GO:0034641,GO:0034654,GO:0036293,GO:0043094,GO:0043173,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044403,GO:0044419,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0050896,GO:0051186,GO:0051188,GO:0051701,GO:0051704,GO:0051707,GO:0055086,GO:0070482,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0075136,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.21 ko:K00763 ko00760,ko01100,map00760,map01100 R01724 RC00033 ko00000,ko00001,ko01000 iYO844.BSU31750 Bacteria COG1488@1,COG1488@2 NA|NA|NA H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP MAG.T1.5_01217 330214.NIDE3776 8.5e-70 270.0 Bacteria pncA GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008936,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0018130,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0030145,GO:0034641,GO:0034654,GO:0043094,GO:0043167,GO:0043169,GO:0043173,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.11.1,3.5.1.19 ko:K08281,ko:K12132 ko00760,ko01100,map00760,map01100 R01268 RC00100 ko00000,ko00001,ko01000,ko01001 iE2348C_1286.E2348C_1895,iECs_1301.ECs2475,iZ_1308.Z2802 Bacteria COG1335@1,COG1335@2 NA|NA|NA Q hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides MAG.T1.5_01218 330214.NIDE3775 3.5e-48 197.6 Nitrospirae ko:K12263 ko00000 Bacteria 3J1AX@40117,COG2010@1,COG2010@2 NA|NA|NA C Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_01220 330214.NIDE3773 0.0 1468.4 Nitrospirae ycbZ 3.4.21.53 ko:K01338,ko:K04076,ko:K04770 ko04112,map04112 ko00000,ko00001,ko01000,ko01002 Bacteria 3J0X2@40117,COG1067@1,COG1067@2 NA|NA|NA O AAA domain MAG.T1.5_01221 330214.NIDE3772 1e-85 322.8 Bacteria raiA ko:K03704,ko:K05809 ko00000,ko03000,ko03009 Bacteria COG1278@1,COG1278@2,COG1544@1,COG1544@2 NA|NA|NA J regulation of translation MAG.T1.5_01222 330214.NIDE3770 9.9e-189 666.0 Bacteria Bacteria COG3173@1,COG3173@2 NA|NA|NA S very-long-chain-acyl-CoA dehydrogenase activity MAG.T1.5_01223 330214.NIDE3769 4.1e-71 274.2 Bacteria cysC 2.7.1.25,2.7.7.4 ko:K00860,ko:K00955 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176 R00509,R00529,R04928,R04929 RC00002,RC00078,RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 Bacteria COG0529@1,COG0529@2 NA|NA|NA P adenylylsulfate kinase activity MAG.T1.5_01224 330214.NIDE3768 0.0 1162.5 Nitrospirae 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 ko00000,ko00001,ko00002,ko01000,ko04147 CBM48,GH13 Bacteria 3J0Y2@40117,COG0296@1,COG0296@2 NA|NA|NA G Alpha amylase, catalytic domain MAG.T1.5_01229 1121396.KB893064_gene1164 3.2e-57 229.6 Desulfobacterales ko:K06871 ko00000 Bacteria 1PZXY@1224,2MK2Q@213118,2WMX1@28221,42RB6@68525,COG0641@1,COG0641@2 NA|NA|NA C 4Fe-4S single cluster domain MAG.T1.5_01231 330214.NIDE3759 4.1e-59 234.2 Bacteria ko:K02348 ko00000 Bacteria COG2153@1,COG2153@2 NA|NA|NA K protein acetylation MAG.T1.5_01232 330214.NIDE3757 4.2e-142 510.8 Bacteria Bacteria COG0589@1,COG0589@2 NA|NA|NA T AMP binding MAG.T1.5_01233 330214.NIDE3756 4.9e-160 570.9 Nitrospirae cusB ko:K15727 ko00000,ko02000 8.A.1.2.1 Bacteria 3J15V@40117,COG0845@1,COG0845@2 NA|NA|NA M Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_01234 330214.NIDE3755 0.0 1766.5 Bacteria ko:K15726 ko00000,ko02000 2.A.6.1.2 Bacteria COG3696@1,COG3696@2 NA|NA|NA P silver ion transport MAG.T1.5_01235 330214.NIDE3754 0.0 1228.8 Nitrospirae mgtA 3.6.3.2 ko:K01531 ko00000,ko01000 3.A.3.4 Bacteria 3J0WH@40117,COG0474@1,COG0474@2 NA|NA|NA P Cation transporter/ATPase, N-terminus MAG.T1.5_01236 330214.NIDE3753 7.5e-243 846.3 Nitrospirae Bacteria 3J10H@40117,COG0745@1,COG0745@2,COG4191@1,COG4191@2 NA|NA|NA T Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_01237 330214.NIDE3752 1.1e-149 536.2 Bacteria yrbG ko:K07301 ko00000,ko02000 2.A.19.5 Bacteria COG0530@1,COG0530@2 NA|NA|NA P calcium, potassium:sodium antiporter activity MAG.T1.5_01239 1340493.JNIF01000003_gene3716 1e-11 77.8 Acidobacteria ko:K21010 ko02025,map02025 ko00000,ko00001 Bacteria 3Y8U1@57723,COG4783@1,COG4783@2 NA|NA|NA S chaperone-mediated protein folding MAG.T1.5_01242 330214.NIDE3747 2.8e-68 264.6 Bacteria Bacteria 2CIIF@1,315FB@2 NA|NA|NA MAG.T1.5_01243 330214.NIDE3745 0.0 1380.5 Nitrospirae yloB GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.8 ko:K01537 ko00000,ko01000 3.A.3.2 iYO844.BSU15650 Bacteria 3J0YX@40117,COG0474@1,COG0474@2 NA|NA|NA P Cation transporter/ATPase, N-terminus MAG.T1.5_01244 330214.NIDE3744 3.9e-127 461.1 Nitrospirae 3.1.3.64 ko:K21302 ko00562,ko01100,ko05152,map00562,map01100,map05152 ko00000,ko00001,ko01000 Bacteria 3J186@40117,COG3511@1,COG3511@2 NA|NA|NA M Phosphoesterase family MAG.T1.5_01245 330214.NIDE3743 1e-304 1052.0 Nitrospirae msbA2 ko:K06147,ko:K11085 ko02010,map02010 ko00000,ko00001,ko01000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 3J0X8@40117,COG1132@1,COG1132@2 NA|NA|NA V Evidence 2a Function of homologous gene experimentally demonstrated in an other organism MAG.T1.5_01248 330214.NIDE3739 1.1e-287 995.3 Nitrospirae nadB GO:0000166,GO:0001716,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008734,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0015922,GO:0016491,GO:0016638,GO:0016641,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044318,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605 1.3.5.1,1.3.5.4,1.4.3.16 ko:K00239,ko:K00244,ko:K00278 ko00020,ko00190,ko00250,ko00620,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00250,map00620,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map02020,map05134 M00009,M00011,M00115,M00149,M00150,M00173,M00374,M00376 R00357,R00481,R02164 RC00006,RC00045,RC02566 ko00000,ko00001,ko00002,ko01000 iAF1260.b2574,iBWG_1329.BWG_2338,iECDH10B_1368.ECDH10B_2742,iECDH1ME8569_1439.ECDH1ME8569_2501,iETEC_1333.ETEC_2787,iEcDH1_1363.EcDH1_1094,iJN678.nadB,iJO1366.b2574,iJR904.b2574,iLF82_1304.LF82_1433,iNRG857_1313.NRG857_12785,iSbBS512_1146.nadB,iY75_1357.Y75_RS13445,iYL1228.KPN_02899 Bacteria 3J0DI@40117,COG0029@1,COG0029@2 NA|NA|NA H FAD binding domain MAG.T1.5_01249 330214.NIDE3738 8.7e-95 353.2 Nitrospirae Bacteria 3J19T@40117,COG0741@1,COG0741@2 NA|NA|NA M Transglycosylase SLT domain MAG.T1.5_01250 330214.NIDE3737 3e-138 498.0 Nitrospirae pabC 2.6.1.42,4.1.3.38 ko:K00826,ko:K02619 ko00270,ko00280,ko00290,ko00770,ko00790,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map00790,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R05553,R10991 RC00006,RC00036,RC01843,RC02148 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 3J0BM@40117,COG0115@1,COG0115@2 NA|NA|NA E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family MAG.T1.5_01251 330214.NIDE3736 6.9e-209 733.4 Nitrospirae pabB GO:0000162,GO:0003674,GO:0003824,GO:0004049,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046820,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 2.6.1.85 ko:K01665 ko00790,map00790 R01716 RC00010,RC01418 ko00000,ko00001,ko01000 Bacteria 3J0FG@40117,COG0147@1,COG0147@2 NA|NA|NA EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia MAG.T1.5_01252 330214.NIDE3735 3.6e-39 167.2 Bacteria atpI ko:K02116 ko00000,ko00194 3.A.2.1 Bacteria COG5336@1,COG5336@2 NA|NA|NA C function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex MAG.T1.5_01253 330214.NIDE3734 3.7e-126 457.6 Nitrospirae atpB ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 Bacteria 3J0RW@40117,COG0356@1,COG0356@2 NA|NA|NA C it plays a direct role in the translocation of protons across the membrane MAG.T1.5_01254 330214.NIDE3733 9.5e-25 119.0 Nitrospirae atpE GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042802,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 ko:K02110,ko:K02124 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157,M00159 ko00000,ko00001,ko00002,ko00194 3.A.2.1,3.A.2.2,3.A.2.3 Bacteria 3J198@40117,COG0636@1,COG0636@2 NA|NA|NA C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation MAG.T1.5_01255 330214.NIDE3732 1.3e-50 206.1 Nitrospirae atpF ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 Bacteria 3J1AE@40117,COG0711@1,COG0711@2 NA|NA|NA C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) MAG.T1.5_01256 330214.NIDE3731 6.1e-114 417.2 Bacteria larE 4.99.1.12 ko:K06864,ko:K09121 ko00000,ko01000 Bacteria COG1606@1,COG1606@2 NA|NA|NA L tRNA processing MAG.T1.5_01257 330214.NIDE3730 7.3e-229 799.7 Nitrospirae ko:K07263 ko00000,ko01000,ko01002 Bacteria 3J0I5@40117,COG0612@1,COG0612@2 NA|NA|NA S Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_01258 330214.NIDE3729 3.5e-231 807.4 Nitrospirae ko:K07263 ko00000,ko01000,ko01002 Bacteria 3J0BY@40117,COG0612@1,COG0612@2 NA|NA|NA S Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_01259 330214.NIDE3728 9.9e-176 622.9 Nitrospirae rlmN GO:0000049,GO:0000154,GO:0001510,GO:0002935,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016426,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0070040,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:0140102,GO:1901360,GO:1901363 2.1.1.192 ko:K06941 ko00000,ko01000,ko03009 Bacteria 3J0CH@40117,COG0820@1,COG0820@2 NA|NA|NA J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs MAG.T1.5_01260 330214.NIDE3727 0.0 1194.5 Nitrospirae slt ko:K05807,ko:K08309 ko00000,ko01000,ko01011,ko02000 1.B.33.1 GH23 Bacteria 3J0VD@40117,COG0457@1,COG0457@2,COG0741@1,COG0741@2,COG1729@1,COG1729@2 NA|NA|NA M Transglycosylase SLT domain MAG.T1.5_01262 330214.NIDE3725 6.1e-40 169.9 Bacteria zapA ko:K09888 ko00000,ko03036 Bacteria COG3027@1,COG3027@2 NA|NA|NA D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division MAG.T1.5_01264 330214.NIDE3723 2.4e-239 834.7 Nitrospirae rny ko:K05802,ko:K18682 ko03018,map03018 ko00000,ko00001,ko01000,ko02000,ko03019 1.A.23.1.1 Bacteria 3J0C8@40117,COG1418@1,COG1418@2,COG4372@1,COG4372@2 NA|NA|NA S Endoribonuclease that initiates mRNA decay MAG.T1.5_01265 330214.NIDE3722 2.4e-133 481.5 Nitrospirae ymdB GO:0003674,GO:0003824,GO:0004112,GO:0004113,GO:0008081,GO:0016787,GO:0016788,GO:0042578 ko:K02029,ko:K02030,ko:K09769 M00236 ko00000,ko00002,ko02000 3.A.1.3 Bacteria 3J0JW@40117,COG1692@1,COG1692@2 NA|NA|NA S YmdB-like protein MAG.T1.5_01266 330214.NIDE3721 4.4e-186 657.5 Nitrospirae xseA 3.1.11.6,3.4.21.102 ko:K03601,ko:K03797 ko03430,map03430 ko00000,ko00001,ko01000,ko01002,ko03400 Bacteria 3J0S9@40117,COG1570@1,COG1570@2 NA|NA|NA L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides MAG.T1.5_01267 330214.NIDE3720 7.1e-34 149.4 Bacteria xseB 3.1.11.6 ko:K03602 ko03430,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria COG1722@1,COG1722@2 NA|NA|NA L exodeoxyribonuclease VII activity MAG.T1.5_01268 330214.NIDE3719 1.3e-114 419.5 Nitrospirae tlyA GO:0000154,GO:0001510,GO:0001897,GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019835,GO:0019836,GO:0022613,GO:0031167,GO:0031640,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035821,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044003,GO:0044004,GO:0044085,GO:0044179,GO:0044237,GO:0044238,GO:0044260,GO:0044364,GO:0044403,GO:0044419,GO:0044764,GO:0046483,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.226,2.1.1.227 ko:K06442 ko00000,ko01000,ko03009 Bacteria 3J0MD@40117,COG1189@1,COG1189@2 NA|NA|NA J FtsJ-like methyltransferase MAG.T1.5_01269 330214.NIDE3718 2.2e-165 588.2 Nitrospirae galE1 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 4.2.1.46,5.1.3.2 ko:K01710,ko:K01784 ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130 M00361,M00362,M00632,M00793 R00291,R02984,R06513 RC00289,RC00402 ko00000,ko00001,ko00002,ko01000 Bacteria 3J12G@40117,COG0451@1,COG0451@2 NA|NA|NA M Polysaccharide biosynthesis protein MAG.T1.5_01270 330214.NIDE3717 3.1e-50 204.1 Nitrospirae pspE Bacteria 3J17U@40117,COG0607@1,COG0607@2 NA|NA|NA P Rhodanese Homology Domain MAG.T1.5_01271 330214.NIDE3715 5.5e-34 150.2 Nitrospirae cutA ko:K03926 ko00000 Bacteria 3J0UM@40117,COG1324@1,COG1324@2 NA|NA|NA P CutA1 divalent ion tolerance protein MAG.T1.5_01272 330214.NIDE3714 6.1e-164 583.6 Nitrospirae ko:K21471,ko:K21472 ko00000,ko01000,ko01002,ko01011 Bacteria 3J0N3@40117,COG0739@1,COG0739@2 NA|NA|NA M Peptidase family M23 MAG.T1.5_01273 330214.NIDE3713 7.2e-279 966.1 Nitrospirae fhs GO:0000096,GO:0000097,GO:0000105,GO:0003674,GO:0003824,GO:0004329,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006144,GO:0006520,GO:0006547,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009108,GO:0009110,GO:0009112,GO:0009113,GO:0009256,GO:0009257,GO:0009396,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0016874,GO:0016879,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0052803,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.5.1.5,3.5.4.9,6.3.4.3 ko:K00288,ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00141,M00377 R00943,R01220,R01655 RC00026,RC00111,RC00202,RC00578 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 3J0CI@40117,COG2759@1,COG2759@2 NA|NA|NA F Formate--tetrahydrofolate ligase MAG.T1.5_01274 330214.NIDE3712 1e-135 489.6 Bacteria hflC GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0031233,GO:0032991,GO:0043086,GO:0043170,GO:0044092,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0098796,GO:0140096,GO:1901564 ko:K04087 M00742 ko00000,ko00002,ko01000 Bacteria COG0330@1,COG0330@2 NA|NA|NA O stress-induced mitochondrial fusion MAG.T1.5_01275 330214.NIDE3711 4.6e-159 567.4 Bacteria hflK ko:K04088 M00742 ko00000,ko00002,ko01000 Bacteria COG0330@1,COG0330@2 NA|NA|NA O stress-induced mitochondrial fusion MAG.T1.5_01277 330214.NIDE3705 0.0 1469.9 Bacteria aoxB 1.20.2.1,1.20.9.1 ko:K08356 ko00000,ko01000,ko02000 5.A.3.6 Bacteria COG0243@1,COG0243@2 NA|NA|NA C molybdopterin cofactor binding MAG.T1.5_01278 330214.NIDE3704 2.9e-69 268.1 Bacteria aoxA 1.20.2.1,1.20.9.1 ko:K08355 ko00000,ko01000,ko02000 5.A.3.6 Bacteria COG0723@1,COG0723@2 NA|NA|NA C oxidoreductase activity, acting on diphenols and related substances as donors MAG.T1.5_01279 330214.NIDE3703 3.7e-255 887.1 Bacteria Bacteria 2ESX4@1,33KFG@2 NA|NA|NA MAG.T1.5_01280 330214.NIDE3702 2.7e-160 571.6 Nitrospirae ko:K03306 ko00000 2.A.20 Bacteria 3J1D1@40117,COG0306@1,COG0306@2 NA|NA|NA P Phosphate transporter family MAG.T1.5_01281 330214.NIDE3701 3.5e-167 594.3 Bacteria Bacteria COG0535@1,COG0535@2 NA|NA|NA I radical SAM domain protein MAG.T1.5_01282 330214.NIDE3700 2.6e-45 188.0 Bacteria ko:K03892 ko00000,ko03000 Bacteria COG0640@1,COG0640@2 NA|NA|NA K DNA-binding transcription factor activity MAG.T1.5_01283 330214.NIDE3699 4.1e-188 664.1 Bacteria 2.1.1.137 ko:K07755 ko00000,ko01000 Bacteria COG0500@1,COG2226@2 NA|NA|NA Q methyltransferase MAG.T1.5_01284 452637.Oter_1218 6.5e-22 110.5 Verrucomicrobia zntR GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0046872,GO:0046914,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 ko:K13638 ko00000,ko03000 Bacteria 46W3K@74201,COG0789@1,COG0789@2 NA|NA|NA K Transcription regulator MerR DNA binding MAG.T1.5_01285 663610.JQKO01000004_gene2870 1.5e-15 89.0 Proteobacteria 4.1.1.44 ko:K01607 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 R03470 RC00938 ko00000,ko00001,ko01000 Bacteria 1P0E1@1224,COG0599@1,COG0599@2 NA|NA|NA S Carboxymuconolactone decarboxylase family MAG.T1.5_01288 869210.Marky_0299 2.2e-28 131.7 Deinococcus-Thermus Bacteria 1WKRN@1297,COG3370@1,COG3370@2 NA|NA|NA S PFAM DsrE DsrF-like family MAG.T1.5_01291 330214.NIDE2124 1.8e-70 271.9 Bacteria ko:K07182 ko00000 Bacteria COG0517@1,COG0517@2 NA|NA|NA S IMP dehydrogenase activity MAG.T1.5_01292 857087.Metme_3572 7.3e-22 109.4 Gammaproteobacteria 5.3.2.6 ko:K01821 ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220 M00569 R03966,R05389 RC01040,RC01355 ko00000,ko00001,ko00002,ko01000 Bacteria 1NBW3@1224,1SECR@1236,COG1942@1,COG1942@2 NA|NA|NA S 4-oxalocrotonate tautomerase MAG.T1.5_01293 330214.NIDE2130 9.7e-71 273.1 Bacteria Bacteria COG2128@1,COG2128@2 NA|NA|NA S hydroperoxide reductase activity MAG.T1.5_01294 1121935.AQXX01000089_gene4660 2.9e-94 351.7 Oceanospirillales Bacteria 1MUWP@1224,1RQ8D@1236,1XHWI@135619,COG1028@1,COG1028@2 NA|NA|NA IQ KR domain MAG.T1.5_01295 1121935.AQXX01000089_gene4659 6.4e-39 166.4 Oceanospirillales ytcD Bacteria 1RH3S@1224,1S6IG@1236,1XJY6@135619,COG1733@1,COG1733@2 NA|NA|NA K HxlR-like helix-turn-helix MAG.T1.5_01296 105559.Nwat_1956 4.6e-16 91.3 Chromatiales Bacteria 1N3R4@1224,1SD9Q@1236,1X22P@135613,2DDG6@1,32U1E@2 NA|NA|NA S Cytochrome C' MAG.T1.5_01297 330214.NIDE3948 1.3e-93 350.1 Bacteria Bacteria 2CB8G@1,2Z88H@2 NA|NA|NA S Putative beta-barrel porin-2, OmpL-like. bbp2 MAG.T1.5_01301 497964.CfE428DRAFT_3716 2.5e-180 638.6 Bacteria nifA ko:K02584 ko02020,map02020 ko00000,ko00001,ko03000 Bacteria COG3604@1,COG3604@2 NA|NA|NA KT transcription factor binding MAG.T1.5_01302 530564.Psta_0275 2.7e-44 185.3 Planctomycetes Bacteria 2IYUM@203682,COG2128@1,COG2128@2 NA|NA|NA O Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity MAG.T1.5_01303 1502850.FG91_02597 3.8e-84 318.2 Alphaproteobacteria Bacteria 1N48X@1224,2U17G@28211,COG1335@1,COG1335@2 NA|NA|NA Q COG1335 Amidases related to nicotinamidase MAG.T1.5_01304 452637.Oter_0294 1.9e-38 165.2 Bacteria Bacteria COG3370@1,COG3370@2 NA|NA|NA O peroxiredoxin activity MAG.T1.5_01305 497964.CfE428DRAFT_3712 1.1e-62 246.5 Verrucomicrobia ko:K07006 ko00000 Bacteria 46SQM@74201,COG3576@1,COG3576@2 NA|NA|NA S Pyridoxamine 5'-phosphate oxidase MAG.T1.5_01306 330214.NIDE0264 2.7e-150 538.5 Bacteria ko:K01999 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria COG0683@1,COG0683@2 NA|NA|NA E ABC-type branched-chain amino acid transport systems, periplasmic component MAG.T1.5_01311 1265503.KB905161_gene3223 1.8e-11 75.5 Colwelliaceae Bacteria 1PCZH@1224,1S9EN@1236,2Q87C@267889,COG5572@1,COG5572@2 NA|NA|NA S Predicted integral membrane protein (DUF2282) MAG.T1.5_01312 381666.H16_A1821 7.7e-88 330.5 Burkholderiaceae ko:K09930 ko00000 Bacteria 1K0J2@119060,1MURE@1224,2VKD3@28216,COG3220@1,COG3220@2 NA|NA|NA S belongs to the UPF0276 family MAG.T1.5_01313 381666.H16_A1820 7.3e-24 117.9 Burkholderiaceae Bacteria 1K4ZZ@119060,1QAP4@1224,2VXJI@28216,COG3219@1,COG3219@2 NA|NA|NA S Putative DNA-binding domain MAG.T1.5_01314 743299.Acife_0770 1.3e-24 119.8 Gammaproteobacteria ko:K15977 ko00000 Bacteria 1N1VA@1224,1SA1R@1236,COG2259@1,COG2259@2 NA|NA|NA S Membrane MAG.T1.5_01315 438753.AZC_3167 1.6e-129 469.5 Xanthobacteraceae ko:K17225 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 Bacteria 1MX9E@1224,2TRK0@28211,3EYQF@335928,COG2041@1,COG2041@2 NA|NA|NA S Mo-co oxidoreductase dimerisation domain MAG.T1.5_01316 381666.H16_B2221 9.9e-52 209.9 Burkholderiaceae ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 Bacteria 1KG4I@119060,1QTYW@1224,2VRNU@28216,COG3258@1,COG3258@2 NA|NA|NA C Cytochrome C oxidase, cbb3-type, subunit III MAG.T1.5_01317 330214.NIDE1147 7.6e-74 283.9 Bacteria Bacteria 292MF@1,2ZQ5C@2 NA|NA|NA S Protein of unknown function (DUF3047) MAG.T1.5_01318 330214.NIDE1146 8.7e-242 842.8 Nitrospirae merA Bacteria 3J0IM@40117,COG1249@1,COG1249@2 NA|NA|NA C Evidence 2a Function of homologous gene experimentally demonstrated in an other organism MAG.T1.5_01319 330214.NIDE1145 1.3e-73 283.1 Bacteria merA Bacteria COG0398@1,COG0398@2 NA|NA|NA M Pfam SNARE associated Golgi protein MAG.T1.5_01321 314230.DSM3645_07550 1.8e-42 179.5 Planctomycetes MA20_14875 GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005515,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009314,GO:0009416,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019216,GO:0019219,GO:0019222,GO:0019747,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042802,GO:0042803,GO:0045828,GO:0045834,GO:0045893,GO:0045935,GO:0046889,GO:0046890,GO:0046983,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071214,GO:0071478,GO:0071482,GO:0080090,GO:0097159,GO:0104004,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1904143,GO:2000112,GO:2001141 ko:K01420,ko:K10914,ko:K22490 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 ko00000,ko00001,ko03000 Bacteria 2IZG1@203682,COG0664@1,COG0664@2 NA|NA|NA K - catabolite gene activator and regulatory subunit of cAMP-dependent protein MAG.T1.5_01322 330214.NIDE4185 4.4e-89 334.7 Bacteria vacJ ko:K04754 ko00000 Bacteria COG2853@1,COG2853@2 NA|NA|NA M Lipoprotein MAG.T1.5_01324 443152.MDG893_17567 1.1e-27 130.6 Gammaproteobacteria Bacteria 1RDZ2@1224,1RYPP@1236,COG0398@1,COG0398@2 NA|NA|NA S TVP38 TMEM64 family inner membrane protein ydjZ MAG.T1.5_01325 671143.DAMO_2648 5.7e-17 94.7 Bacteria ko:K03286,ko:K12976,ko:K16079 ko00000,ko01000,ko01005,ko02000 1.B.4.2.1,1.B.6 Bacteria COG3637@1,COG3637@2 NA|NA|NA M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety MAG.T1.5_01326 1210884.HG799465_gene12253 1.5e-20 106.3 Planctomycetes Bacteria 2J1JD@203682,COG2128@1,COG2128@2 NA|NA|NA S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity MAG.T1.5_01327 1049564.TevJSym_ar00440 1.6e-82 313.2 Gammaproteobacteria Bacteria 1N82C@1224,1RQQI@1236,COG2128@1,COG2128@2 NA|NA|NA S Protein of unknown function (DUF3179) MAG.T1.5_01331 330214.NIDE3686 3.1e-70 271.2 Bacteria glbN ko:K06886 ko00000 Bacteria COG2346@1,COG2346@2 NA|NA|NA O COG2346, Truncated hemoglobins MAG.T1.5_01332 330214.NIDE3685 1.4e-91 342.4 Bacteria sigK GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0010468,GO:0010565,GO:0016020,GO:0019216,GO:0019217,GO:0019222,GO:0030312,GO:0031323,GO:0044464,GO:0050789,GO:0050794,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090 ko:K03088 ko00000,ko03021 Bacteria COG1595@1,COG1595@2 NA|NA|NA K DNA-templated transcription, initiation MAG.T1.5_01333 330214.NIDE3684 1.4e-80 305.8 Bacteria ko:K07167 ko00000 Bacteria COG3806@1,COG3806@2 NA|NA|NA T Anti-sigma factor MAG.T1.5_01334 330214.NIDE3683 1.1e-43 182.6 Bacteria Bacteria 2CNK3@1,32SH9@2 NA|NA|NA S Protein of Unknown function (DUF2784) MAG.T1.5_01335 1163408.UU9_09087 9.9e-47 193.4 Xanthomonadales Bacteria 1RDGV@1224,1S5VD@1236,1XBWX@135614,COG5483@1,COG5483@2 NA|NA|NA S Protein of unknown function, DUF488 MAG.T1.5_01336 330214.NIDE3682 7.7e-40 169.9 Bacteria ko:K07343 ko00000 Bacteria COG3070@1,COG3070@2 NA|NA|NA K positive regulation of type IV pilus biogenesis MAG.T1.5_01339 330214.NIDE3680 3.5e-144 517.7 Bacteria Bacteria COG0500@1,COG2226@2 NA|NA|NA Q methyltransferase MAG.T1.5_01340 661478.OP10G_4489 4.5e-19 101.3 Bacteria Bacteria 2A52F@1,30TQU@2 NA|NA|NA MAG.T1.5_01341 330214.NIDE3677 4.8e-68 264.2 Bacteria Bacteria 297W1@1,2ZV2M@2 NA|NA|NA S Domain of unknown function (DUF4396) MAG.T1.5_01342 330214.NIDE3676 8.3e-155 553.1 Bacteria Bacteria 2DBP7@1,2ZA82@2 NA|NA|NA MAG.T1.5_01343 330214.NIDE3675 5.6e-125 453.8 Bacteria Bacteria 2DKWD@1,30KRK@2 NA|NA|NA MAG.T1.5_01346 330214.NIDE1789 1.6e-19 102.4 Bacteria Bacteria COG3293@1,COG3293@2 NA|NA|NA L Transposase MAG.T1.5_01347 29581.BW37_01210 7e-36 158.7 Oxalobacteraceae ko:K07001 ko00000 Bacteria 1MUI6@1224,2WDK7@28216,4786Z@75682,COG1752@1,COG1752@2 NA|NA|NA S Patatin-like phospholipase MAG.T1.5_01350 1463917.JODC01000028_gene932 2.5e-08 66.6 Actinobacteria Bacteria 2DBJW@1,2IDBS@201174,2Z9P2@2 NA|NA|NA MAG.T1.5_01351 861299.J421_5702 1.9e-33 149.8 Gemmatimonadetes Bacteria 1ZTKN@142182,COG4454@1,COG4454@2 NA|NA|NA MAG.T1.5_01353 330214.NIDE3664 1.4e-119 436.0 Nitrospirae ko:K07088 ko00000 Bacteria 3J1EB@40117,COG0679@1,COG0679@2 NA|NA|NA S Membrane transport protein MAG.T1.5_01354 330214.NIDE3663 5.2e-207 726.9 Nitrospirae tetA ko:K08151,ko:K08153 M00668,M00717 ko00000,ko00002,ko01504,ko02000 2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75,2.A.1.2.8 Bacteria 3J1CK@40117,COG0477@1,COG2814@2 NA|NA|NA EGP Sugar (and other) transporter MAG.T1.5_01356 330214.NIDE3657 5.9e-68 263.8 Bacteria Bacteria COG0464@1,COG0464@2 NA|NA|NA O ATPase activity MAG.T1.5_01357 330214.NIDE3656 4e-29 133.7 Bacteria yhbQ GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 ko:K07461 ko00000 Bacteria COG2827@1,COG2827@2 NA|NA|NA L Endonuclease containing a URI domain MAG.T1.5_01360 330214.NIDE3653 7.9e-41 173.3 Bacteria Bacteria COG3631@1,COG3631@2 NA|NA|NA S light absorption MAG.T1.5_01361 330214.NIDE3652 2.8e-31 141.7 Bacteria Bacteria COG3305@1,COG3305@2 NA|NA|NA S Predicted membrane protein (DUF2127) MAG.T1.5_01362 330214.NIDE1368 8.1e-08 63.5 Bacteria opuCA 2.7.7.7 ko:K02342,ko:K05847,ko:K07182 ko00230,ko00240,ko01100,ko02010,ko03030,ko03430,ko03440,map00230,map00240,map01100,map02010,map03030,map03430,map03440 M00209,M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko02000,ko03032,ko03400 3.A.1.12 Bacteria COG2905@1,COG2905@2 NA|NA|NA T signal-transduction protein containing cAMP-binding and CBS domains MAG.T1.5_01363 330214.NIDE3650 4.8e-103 380.9 Bacteria qcrC GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K00406,ko:K03889 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00151,M00156 ko00000,ko00001,ko00002 3.D.4.3 Bacteria COG2010@1,COG2010@2 NA|NA|NA C Cytochrome c MAG.T1.5_01364 330214.NIDE3647 9.1e-96 356.3 Bacteria ompW ko:K07275 ko00000 Bacteria COG3047@1,COG3047@2 NA|NA|NA MAG.T1.5_01365 330214.NIDE3646 2.6e-61 241.5 Bacteria acuB ko:K04767,ko:K07182 ko00000 Bacteria COG0517@1,COG0517@2 NA|NA|NA S IMP dehydrogenase activity MAG.T1.5_01366 330214.NIDE3643 2.5e-121 441.4 Nitrospirae ppa 3.6.1.1 ko:K01507 ko00190,map00190 ko00000,ko00001,ko01000 Bacteria 3J184@40117,COG0221@1,COG0221@2 NA|NA|NA C Inorganic pyrophosphatase MAG.T1.5_01367 330214.NIDE3642 1.8e-296 1024.6 Bacteria deaD GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003724,GO:0003725,GO:0003727,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006417,GO:0006725,GO:0006807,GO:0006950,GO:0006996,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009987,GO:0010468,GO:0010501,GO:0010556,GO:0010557,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019439,GO:0022607,GO:0022613,GO:0022618,GO:0030312,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031330,GO:0032268,GO:0032270,GO:0032574,GO:0032575,GO:0033554,GO:0033592,GO:0034057,GO:0034248,GO:0034250,GO:0034458,GO:0034459,GO:0034622,GO:0034641,GO:0034655,GO:0042254,GO:0042255,GO:0042273,GO:0042623,GO:0043170,GO:0043487,GO:0043488,GO:0043489,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045934,GO:0046483,GO:0046700,GO:0048255,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051247,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0061013,GO:0065003,GO:0065007,GO:0065008,GO:0070035,GO:0070417,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097617,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902369,GO:1902373,GO:1903311,GO:1903312,GO:2000112 3.6.4.13 ko:K05592 ko03018,map03018 ko00000,ko00001,ko01000,ko03009,ko03019 Bacteria COG0513@1,COG0513@2 NA|NA|NA L helicase activity MAG.T1.5_01368 1535422.ND16A_1874 1.7e-54 219.2 Gammaproteobacteria Bacteria 1MWPR@1224,1S7W4@1236,COG1765@1,COG1765@2 NA|NA|NA O OsmC-like protein MAG.T1.5_01369 1123368.AUIS01000032_gene1401 2.7e-28 131.7 Gammaproteobacteria Bacteria 1N688@1224,1SS8Q@1236,2D5Q1@1,32TJK@2 NA|NA|NA MAG.T1.5_01370 404589.Anae109_4242 2.2e-199 702.2 Myxococcales ko:K15836 ko00000,ko03000 Bacteria 1NU8B@1224,2X6YU@28221,2YYW6@29,43BKG@68525,COG3829@1,COG3829@2 NA|NA|NA K ATPase associated with various cellular activities, AAA_5 MAG.T1.5_01371 330214.NIDE3639 3.5e-288 996.9 Bacteria sdrA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria COG1061@1,COG1061@2 NA|NA|NA L Type III restriction enzyme res subunit MAG.T1.5_01372 330214.NIDE3638 2.2e-59 235.3 Bacteria Bacteria COG0464@1,COG0464@2 NA|NA|NA O ATPase activity MAG.T1.5_01374 313612.L8106_02157 5.5e-16 92.4 Oscillatoriales Bacteria 1G3Y8@1117,1H8QZ@1150,COG2755@1,COG2755@2 NA|NA|NA E SGNH hydrolase-like domain, acetyltransferase AlgX MAG.T1.5_01375 330214.NIDE3635 1.5e-302 1044.6 Nitrospirae prfC GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016150,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02837,ko:K07133 ko00000,ko03012 Bacteria 3J0WP@40117,COG4108@1,COG4108@2 NA|NA|NA J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP MAG.T1.5_01377 330214.NIDE3631 2.8e-134 484.6 Bacteria Bacteria COG1403@1,COG1403@2 NA|NA|NA V endonuclease activity MAG.T1.5_01378 330214.NIDE3630 9.2e-34 149.1 Bacteria YPO1157 GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0097159,GO:1901363 ko:K06867 ko00000 Bacteria COG4628@1,COG4628@2 NA|NA|NA S conserved protein (DUF2132) MAG.T1.5_01379 330214.NIDE3629 1.4e-85 322.4 Bacteria yaeQ Bacteria COG4681@1,COG4681@2 NA|NA|NA S YaeQ MAG.T1.5_01380 330214.NIDE3628 2.7e-51 208.0 Bacteria yciH GO:0001731,GO:0002181,GO:0002183,GO:0002188,GO:0002190,GO:0002192,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0110017,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K03113 ko03013,map03013 ko00000,ko00001,ko03012 Bacteria COG0023@1,COG0023@2 NA|NA|NA J translation initiation factor activity MAG.T1.5_01381 330214.NIDE3627 2.1e-157 562.0 Bacteria yhaZ Bacteria COG4335@1,COG4335@2 NA|NA|NA L DNA alkylation repair MAG.T1.5_01382 670292.JH26_11125 1.7e-60 239.2 Alphaproteobacteria Bacteria 1RA3U@1224,2U640@28211,COG1028@1,COG1028@2 NA|NA|NA IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) MAG.T1.5_01384 330214.NIDE3623 8.3e-135 486.5 Bacteria ytbE Bacteria COG0656@1,COG0656@2 NA|NA|NA S aldo-keto reductase (NADP) activity MAG.T1.5_01385 330214.NIDE3622 7e-239 833.2 Bacteria ko:K03316 ko00000 2.A.36 Bacteria COG0025@1,COG0025@2 NA|NA|NA P sodium:proton antiporter activity MAG.T1.5_01386 330214.NIDE3621 1.7e-70 272.3 Bacteria ompW ko:K07275 ko00000 Bacteria COG3047@1,COG3047@2 NA|NA|NA MAG.T1.5_01387 330214.NIDE3620 4.2e-51 207.6 Bacteria aacA7 GO:0003674,GO:0003824,GO:0008080,GO:0008150,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0034069,GO:0042221,GO:0046677,GO:0047663,GO:0050896 2.3.1.82 ko:K18816 br01600,ko00000,ko01000,ko01504 Bacteria COG0454@1,COG0456@2 NA|NA|NA K acetyltransferase MAG.T1.5_01388 330214.NIDE3619 3.9e-47 194.5 Nitrospirae Bacteria 29KDN@1,307AY@2,3J14Y@40117 NA|NA|NA MAG.T1.5_01389 330214.NIDE3618 6e-198 696.8 Bacteria ko:K07007 ko00000 Bacteria COG2081@1,COG2081@2 NA|NA|NA N HI0933 family MAG.T1.5_01390 330214.NIDE3617 1.4e-69 269.2 Bacteria 1.3.1.75 ko:K07002,ko:K19073 ko00860,ko01100,ko01110,map00860,map01100,map01110 R06272,R06896 RC01376 ko00000,ko00001,ko01000 Bacteria COG3545@1,COG3545@2 NA|NA|NA S Serine hydrolase MAG.T1.5_01392 330214.NIDE3616 1.4e-110 406.0 Bacteria 3.5.1.53 ko:K11206,ko:K12251 ko00330,ko01100,map00330,map01100 R01152 RC00096 ko00000,ko00001,ko01000 Bacteria COG0388@1,COG0388@2 NA|NA|NA S hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds MAG.T1.5_01393 330214.NIDE2515 5.7e-118 432.6 Bacteria ko:K07290 ko00000 9.B.121 Bacteria COG2982@1,COG2982@2 NA|NA|NA M Protein involved in outer membrane biogenesis MAG.T1.5_01395 330214.NIDE3615 6.7e-192 676.8 Nitrospirae ko:K07007 ko00000 Bacteria 3J12U@40117,COG2081@1,COG2081@2 NA|NA|NA S HI0933-like protein MAG.T1.5_01396 330214.NIDE3614 9.1e-160 569.7 Bacteria Bacteria COG3137@1,COG3137@2 NA|NA|NA MAG.T1.5_01397 330214.NIDE3612 2.7e-187 661.4 Bacteria Bacteria 2C8FN@1,2ZBER@2 NA|NA|NA MAG.T1.5_01398 330214.NIDE3611 2.2e-162 578.6 Bacteria yagE Bacteria COG1723@1,COG1723@2 NA|NA|NA S PFAM Uncharacterised ACR, YagE family COG1723 MAG.T1.5_01399 330214.NIDE1522 6.2e-40 171.0 Nitrospirae yieH 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 R01334 RC00017 ko00000,ko00001,ko01000 Bacteria 3J15X@40117,COG0637@1,COG0637@2 NA|NA|NA S Haloacid dehalogenase-like hydrolase MAG.T1.5_01400 439235.Dalk_0524 3.1e-235 821.6 Desulfobacterales 4.1.3.25,4.1.3.34 ko:K01644,ko:K18292 ko00660,ko01100,ko02020,map00660,map01100,map02020 R00237,R00362 RC00067,RC00502,RC01118,RC01205 ko00000,ko00001,ko01000 Bacteria 1NAM2@1224,2MJ35@213118,2WJIP@28221,42P8P@68525,COG2301@1,COG2301@2 NA|NA|NA G Belongs to the HpcH HpaI aldolase family MAG.T1.5_01401 338963.Pcar_2301 2.5e-109 402.1 Desulfuromonadales psd 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 Bacteria 1MVT4@1224,2WJV9@28221,42PAW@68525,43TFP@69541,COG0688@1,COG0688@2 NA|NA|NA I Belongs to the phosphatidylserine decarboxylase family MAG.T1.5_01402 1121405.dsmv_1639 6.3e-79 301.2 Desulfobacterales lgt ko:K13292 ko00000,ko01000 Bacteria 1NB9I@1224,2MIP1@213118,2WJU5@28221,42M7E@68525,COG0682@1,COG0682@2 NA|NA|NA M PFAM prolipoprotein diacylglyceryl transferase MAG.T1.5_01403 644282.Deba_1508 4.7e-08 65.1 Deltaproteobacteria Bacteria 1NNP4@1224,2WRZ3@28221,42VPE@68525,COG0457@1,COG0457@2 NA|NA|NA S Tetratricopeptide repeat MAG.T1.5_01404 1235457.C404_24060 9e-186 656.8 Burkholderiaceae pitA ko:K03306 ko00000 2.A.20 Bacteria 1K3WI@119060,1MVXK@1224,2VI71@28216,COG0306@1,COG0306@2 NA|NA|NA P phosphate transporter MAG.T1.5_01406 330214.NIDE3609 1.2e-144 519.2 Bacteria Bacteria COG4221@1,COG4221@2 NA|NA|NA IQ oxidoreductase activity MAG.T1.5_01407 330214.NIDE3608 2.9e-225 787.7 Bacteria Bacteria COG1874@1,COG1874@2 NA|NA|NA G beta-galactosidase activity MAG.T1.5_01408 330214.NIDE3607 2.2e-123 448.7 Bacteria ko:K20977 ko02020,ko02025,map02020,map02025 M00820 ko00000,ko00001,ko00002,ko02022 Bacteria COG0745@1,COG0745@2,COG2172@1,COG2172@2 NA|NA|NA T sigma factor antagonist activity MAG.T1.5_01409 330214.NIDE3605 1.2e-110 406.0 Bacteria fkpA 5.2.1.8 ko:K01802,ko:K03772,ko:K03773 ko00000,ko01000,ko03110 Bacteria COG0545@1,COG0545@2 NA|NA|NA O Peptidyl-prolyl cis-trans isomerase MAG.T1.5_01410 330214.NIDE3604 5.5e-151 540.4 Bacteria yqjG GO:0003674,GO:0003824,GO:0004364,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0016491,GO:0016667,GO:0016672,GO:0016740,GO:0016765,GO:0042221,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.8.5.7,2.5.1.18 ko:K00799,ko:K07393 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 iECW_1372.ECW_m3373,iWFL_1372.ECW_m3373 Bacteria COG0435@1,COG0435@2 NA|NA|NA O Glutathione S-transferase MAG.T1.5_01412 330214.NIDE3598 1.1e-156 559.3 Bacteria Bacteria COG0702@1,COG0702@2 NA|NA|NA GM epimerase MAG.T1.5_01415 330214.NIDE3595 3e-220 771.2 Bacteria putP ko:K03307,ko:K14387 ko04725,ko05231,map04725,map05231 ko00000,ko00001,ko02000 2.A.21,2.A.21.8 Bacteria COG0591@1,COG0591@2 NA|NA|NA E symporter activity MAG.T1.5_01416 330214.NIDE3593 0.0 1293.1 Nitrospirae Bacteria 3J10H@40117,COG0784@1,COG0784@2,COG2202@1,COG2202@2,COG4191@1,COG4191@2 NA|NA|NA T Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_01417 330214.NIDE3592 1.4e-238 832.0 Bacteria fadL ko:K06076 ko00000,ko02000 1.B.9 Bacteria COG2067@1,COG2067@2 NA|NA|NA I long-chain fatty acid transporting porin activity MAG.T1.5_01418 330214.NIDE3591 0.0 1287.7 Nitrospirae mrcB 2.4.1.129,3.4.16.4 ko:K03814,ko:K05365 ko00550,map00550 R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 GT51 Bacteria 3J1FP@40117,COG0744@1,COG0744@2 NA|NA|NA M Transglycosylase MAG.T1.5_01419 330214.NIDE3590 2.8e-65 254.6 Bacteria Bacteria COG1664@1,COG1664@2 NA|NA|NA M Polymer-forming cytoskeletal MAG.T1.5_01420 330214.NIDE3589 2e-173 615.1 Nitrospirae GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 Bacteria 3J0SZ@40117,COG0628@1,COG0628@2 NA|NA|NA S AI-2E family transporter MAG.T1.5_01421 330214.NIDE3588 4.1e-96 357.5 Bacteria ko:K03406 ko02020,ko02030,map02020,map02030 ko00000,ko00001,ko02035 Bacteria COG4191@1,COG4191@2 NA|NA|NA T Histidine kinase MAG.T1.5_01422 330214.NIDE3587 0.0 1410.6 Bacteria 2.7.13.3 ko:K07638 ko02020,ko02026,map02020,map02026 M00445,M00742,M00743 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria COG3850@1,COG3850@2,COG4191@1,COG4191@2 NA|NA|NA T phosphorelay sensor kinase activity MAG.T1.5_01423 330214.NIDE3586 5.3e-163 580.5 Bacteria 2.7.8.33,2.7.8.35 ko:K02851 R08856 RC00002 ko00000,ko01000,ko01003,ko01005 Bacteria COG1086@1,COG1086@2,COG4191@1,COG4191@2 NA|NA|NA GM Polysaccharide biosynthesis protein MAG.T1.5_01424 330214.NIDE3585 1.1e-71 276.2 Bacteria Bacteria COG2204@1,COG2204@2 NA|NA|NA T phosphorelay signal transduction system MAG.T1.5_01425 330214.NIDE3584 1.2e-42 179.1 Bacteria Bacteria 2DGQ2@1,2ZWWE@2 NA|NA|NA MAG.T1.5_01426 330214.NIDE3583 2.7e-30 137.5 Bacteria bolA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0019538,GO:0022603,GO:0022604,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051604,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097428,GO:0097659,GO:0106035,GO:1901360,GO:1901362,GO:1901564,GO:1901576 ko:K05527,ko:K22066 ko00000,ko03000,ko03029 Bacteria COG0271@1,COG0271@2 NA|NA|NA T Belongs to the BolA IbaG family MAG.T1.5_01427 330214.NIDE3582 6.2e-54 216.5 Bacteria grxD GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051536,GO:0051537,GO:0051540 ko:K07390 ko00000,ko03029,ko03110 iPC815.YPO2383,iYL1228.KPN_01992 Bacteria COG0278@1,COG0278@2 NA|NA|NA O protein disulfide oxidoreductase activity MAG.T1.5_01428 330214.NIDE3581 2.7e-218 764.6 Bacteria Bacteria COG0382@1,COG0382@2,COG0560@1,COG0560@2 NA|NA|NA H Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate MAG.T1.5_01429 649638.Trad_1872 9.2e-45 187.2 Deinococcus-Thermus Bacteria 1WIJC@1297,COG1028@1,COG1028@2 NA|NA|NA IQ Short-chain dehydrogenase reductase SDR MAG.T1.5_01430 330214.NIDE3579 3.3e-114 417.9 Bacteria ko:K09931 ko00000 Bacteria COG3222@1,COG3222@2 NA|NA|NA S Uncharacterized protein conserved in bacteria (DUF2064) MAG.T1.5_01434 330214.NIDE3575 2.5e-206 724.5 Nitrospirae dcd 3.5.4.13 ko:K01494 ko00240,ko01100,map00240,map01100 M00053 R00568,R02325 RC00074 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0WG@40117,COG0717@1,COG0717@2 NA|NA|NA F 2'-deoxycytidine 5'-triphosphate deaminase (DCD) MAG.T1.5_01435 330214.NIDE3574 2.1e-213 748.0 Nitrospirae kamA 5.4.3.2 ko:K01843 ko00310,map00310 R00461 RC00303 ko00000,ko00001,ko01000 Bacteria 3J0W3@40117,COG1509@1,COG1509@2 NA|NA|NA C Lysine-2,3-aminomutase MAG.T1.5_01436 330214.NIDE3573 3e-37 160.6 Bacteria 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 Bacteria COG0625@1,COG0625@2 NA|NA|NA O glutathione transferase activity MAG.T1.5_01437 330214.NIDE3572 6.2e-243 846.7 Nitrospirae Bacteria 28MGX@1,2ZATZ@2,3J0YU@40117 NA|NA|NA MAG.T1.5_01438 330214.NIDE3571 9.2e-209 733.0 Bacteria ko:K01163,ko:K06940 ko00000 Bacteria COG0727@1,COG0727@2,COG4866@1,COG4866@2 NA|NA|NA S Uncharacterised conserved protein (DUF2156) MAG.T1.5_01439 330214.NIDE3570 0.0 1915.6 Nitrospirae 2.7.13.3 ko:K11527 ko00000,ko01000,ko01001,ko02022 Bacteria 3J10H@40117,COG2203@1,COG2203@2,COG3437@1,COG3437@2,COG4191@1,COG4191@2 NA|NA|NA T Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_01440 330214.NIDE3569 4.9e-143 513.8 Bacteria norQ ko:K04748 R00294 RC02794 ko00000 3.D.4.10 Bacteria COG0714@1,COG0714@2 NA|NA|NA KLT Associated with various cellular activities MAG.T1.5_01441 153948.NAL212_1927 5e-07 61.2 Nitrosomonadales Bacteria 1N56Z@1224,2C8BN@1,2W56V@28216,32RKS@2,373EQ@32003 NA|NA|NA S Glycine-zipper domain MAG.T1.5_01442 330214.NIDE3566 6.6e-159 567.0 Nitrospirae Bacteria 3J1BG@40117,COG2234@1,COG2234@2 NA|NA|NA S Peptidase family M28 MAG.T1.5_01443 330214.NIDE3565 4.5e-71 273.9 Bacteria ftrC GO:0003674,GO:0003824,GO:0005488,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0015979,GO:0016491,GO:0016730,GO:0022900,GO:0030385,GO:0044237,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114 1.8.7.2 ko:K17892 ko00000,ko01000 Bacteria COG4802@1,COG4802@2 NA|NA|NA C ferredoxin-thioredoxin reductase activity MAG.T1.5_01444 330214.NIDE3564 0.0 1446.0 Bacteria ko:K02448 R00294 RC02794 ko00000 3.D.4.10 Bacteria COG4548@1,COG4548@2 NA|NA|NA P von Willebrand factor (vWF) type A domain MAG.T1.5_01445 330214.NIDE3563 3e-69 267.7 Bacteria Bacteria 2DESJ@1,2ZP2P@2 NA|NA|NA MAG.T1.5_01446 330214.NIDE3562 1e-157 562.8 Nitrospirae mdh 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0EG@40117,COG0039@1,COG0039@2 NA|NA|NA C Catalyzes the reversible oxidation of malate to oxaloacetate MAG.T1.5_01447 330214.NIDE3561 1.5e-103 382.1 Nitrospirae Bacteria 3J19B@40117,COG3748@1,COG3748@2 NA|NA|NA S Pfam:DUF989 MAG.T1.5_01448 330214.NIDE3560 7e-245 852.8 Nitrospirae nuoF2 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 3J0WA@40117,COG1894@1,COG1894@2 NA|NA|NA C NADH-ubiquinone oxidoreductase-F iron-sulfur binding region MAG.T1.5_01449 330214.NIDE3559 5.6e-56 223.4 Bacteria fdx GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006790,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016043,GO:0016226,GO:0016491,GO:0022607,GO:0022900,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051540,GO:0055114,GO:0071840 ko:K04755 ko00000 Bacteria COG0633@1,COG0633@2 NA|NA|NA C Ferredoxin MAG.T1.5_01450 330214.NIDE3558 7.5e-52 209.5 Nitrospirae ko:K13628,ko:K15724 ko00000,ko03016 Bacteria 3J0TZ@40117,COG0316@1,COG0316@2 NA|NA|NA S Belongs to the HesB IscA family MAG.T1.5_01451 330214.NIDE3556 5.2e-67 260.4 Bacteria ygcM 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 Bacteria COG0720@1,COG0720@2 NA|NA|NA H synthase MAG.T1.5_01452 330214.NIDE3555 1.9e-107 395.2 Nitrospirae folE GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006082,GO:0006139,GO:0006575,GO:0006725,GO:0006729,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008616,GO:0009058,GO:0009108,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0019752,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0042455,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901657,GO:1901659 2.7.6.3,3.5.4.16 ko:K00950,ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R03503,R04639,R05046,R05048 RC00002,RC00017,RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 iECNA114_1301.folE,iIT341.HP0928,iJN678.folE,iNJ661.Rv3609c Bacteria 3J0Q0@40117,COG0302@1,COG0302@2 NA|NA|NA F GTP cyclohydrolase I MAG.T1.5_01453 330214.NIDE3554 3.9e-113 414.5 Bacteria pcaD Bacteria COG0596@1,COG0596@2 NA|NA|NA S hydrolase activity, acting on ester bonds MAG.T1.5_01454 330214.NIDE3553 3.4e-207 727.6 Nitrospirae rarA GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0030894,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576 ko:K07478 ko00000 Bacteria 3J0H6@40117,COG2256@1,COG2256@2 NA|NA|NA L MgsA AAA+ ATPase C terminal MAG.T1.5_01456 330214.NIDE3551 3.8e-310 1070.1 Nitrospirae ko:K06158 ko00000,ko03012 Bacteria 3J0W6@40117,COG0488@1,COG0488@2 NA|NA|NA S ABC transporter MAG.T1.5_01459 330214.NIDE3548 5.2e-248 863.2 Nitrospirae purA GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046033,GO:0046040,GO:0046085,GO:0046086,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 iECNA114_1301.ECNA114_4393,iECSF_1327.ECSF_4063,iJN746.PP_4889 Bacteria 3J0FV@40117,COG0104@1,COG0104@2 NA|NA|NA F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP MAG.T1.5_01463 292415.Tbd_1491 7.7e-295 1019.6 Betaproteobacteria 2.1.1.72 ko:K00571,ko:K07316 ko00000,ko01000,ko02048 Bacteria 1MX9M@1224,2VGZB@28216,COG2189@1,COG2189@2 NA|NA|NA L PFAM DNA methylase N-4 N-6 MAG.T1.5_01464 1117958.PE143B_0100090 5.7e-179 634.0 Gammaproteobacteria mloB Bacteria 1MXG1@1224,1RY9W@1236,COG2865@1,COG2865@2 NA|NA|NA K Putative ATP-dependent DNA helicase recG C-terminal MAG.T1.5_01465 292415.Tbd_1492 0.0 1457.2 Betaproteobacteria 3.1.21.5 ko:K01156 ko00000,ko01000,ko02048 Bacteria 1MXFH@1224,2WGXI@28216,COG1061@1,COG1061@2 NA|NA|NA KL Type III restriction enzyme, res subunit MAG.T1.5_01468 330214.NIDE1263 6.5e-99 367.1 Bacteria Bacteria 29A8R@1,2ZX9N@2 NA|NA|NA MAG.T1.5_01470 330214.NIDE1261 3.8e-55 221.1 Bacteria Bacteria COG0784@1,COG0784@2 NA|NA|NA T Response regulator, receiver MAG.T1.5_01471 330214.NIDE1259 5.7e-114 418.3 Bacteria Bacteria 2AKRW@1,31BIT@2 NA|NA|NA MAG.T1.5_01472 330214.NIDE1258 1e-40 172.2 Bacteria Bacteria COG1522@1,COG1522@2 NA|NA|NA K sequence-specific DNA binding MAG.T1.5_01474 330214.NIDE1256 3.3e-229 800.8 Nitrospirae nla28 ko:K07713,ko:K07714 ko02020,map02020 M00499,M00500 ko00000,ko00001,ko00002,ko02022 Bacteria 3J10B@40117,COG2204@1,COG2204@2 NA|NA|NA T Sigma-54 interaction domain MAG.T1.5_01475 330214.NIDE1255 6.2e-181 640.2 Nitrospirae 2.7.13.3 ko:K07709 ko02020,map02020 M00499 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 3J14D@40117,COG4191@1,COG4191@2 NA|NA|NA T His Kinase A (phosphoacceptor) domain MAG.T1.5_01476 330214.NIDE1254 0.0 1271.1 Nitrospirae malQ 2.4.1.18,2.4.1.25 ko:K00700,ko:K00705 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110,R05196 RC00049 ko00000,ko00001,ko00002,ko01000,ko04147 CBM48,GH13,GH77 iJN678.malQ Bacteria 3J106@40117,COG1640@1,COG1640@2 NA|NA|NA G 4-alpha-glucanotransferase MAG.T1.5_01477 330214.NIDE2246 1.8e-85 322.8 Bacteria Bacteria COG1801@1,COG1801@2 NA|NA|NA L Protein of unknown function DUF72 MAG.T1.5_01479 330214.NIDE1252 1.2e-142 512.7 Bacteria Bacteria COG0330@1,COG0330@2 NA|NA|NA O stress-induced mitochondrial fusion MAG.T1.5_01480 330214.NIDE1251 7e-60 236.5 Bacteria Bacteria COG2010@1,COG2010@2 NA|NA|NA C Cytochrome c MAG.T1.5_01482 330214.NIDE1249 3.8e-101 374.4 Nitrospirae queC 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 R09978 RC00959 ko00000,ko00001,ko01000,ko03016 iAF987.Gmet_3075 Bacteria 3J0NP@40117,COG0603@1,COG0603@2 NA|NA|NA H Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) MAG.T1.5_01483 330214.NIDE1248 2.9e-86 324.7 Nitrospirae ko:K06204 ko02026,map02026 ko00000,ko00001,ko03000,ko03009,ko03021 Bacteria 3J0R1@40117,COG1734@1,COG1734@2 NA|NA|NA T Prokaryotic dksA/traR C4-type zinc finger MAG.T1.5_01484 330214.NIDE1247 1.3e-82 312.4 Nitrospirae apt 2.4.2.7 ko:K00759 ko00230,ko01100,map00230,map01100 R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko04147 Bacteria 3J14T@40117,COG0503@1,COG0503@2 NA|NA|NA F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis MAG.T1.5_01485 330214.NIDE1246 1.3e-145 522.7 Nitrospirae Bacteria 3J0E4@40117,COG0568@1,COG0568@2 NA|NA|NA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released MAG.T1.5_01486 330214.NIDE1245 3.3e-35 154.1 Bacteria acyP GO:0003674,GO:0003824,GO:0003998,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016787,GO:0016817,GO:0016818,GO:0050896 3.6.1.7 ko:K01512 ko00620,ko00627,ko01120,map00620,map00627,map01120 R00317,R01421,R01515 RC00043 ko00000,ko00001,ko01000 iSB619.SA_RS07020,iSBO_1134.SBO_2263,iSF_1195.SF0969,iSFxv_1172.SFxv_1053,iS_1188.S1036 Bacteria COG1254@1,COG1254@2 NA|NA|NA C Belongs to the acylphosphatase family MAG.T1.5_01488 330214.NIDE1244 1.2e-173 615.9 Bacteria ald GO:0000286,GO:0001666,GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009628,GO:0009653,GO:0009987,GO:0016020,GO:0016054,GO:0016491,GO:0016638,GO:0019752,GO:0030154,GO:0030312,GO:0030435,GO:0032502,GO:0036293,GO:0043436,GO:0043934,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0048646,GO:0048856,GO:0048869,GO:0050896,GO:0055114,GO:0070482,GO:0071704,GO:0071944,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 R00396 RC00008 ko00000,ko00001,ko01000 iAF987.Gmet_1099 Bacteria COG0686@1,COG0686@2 NA|NA|NA E alanine dehydrogenase activity MAG.T1.5_01489 330214.NIDE1243 6.8e-57 226.5 Nitrospirae Bacteria 2CDBX@1,2ZUMJ@2,3J1B0@40117 NA|NA|NA MAG.T1.5_01490 330214.NIDE1242 1.7e-57 228.4 Nitrospirae Bacteria 3J1DT@40117,COG3411@1,COG3411@2 NA|NA|NA C Ferredoxin MAG.T1.5_01491 330214.NIDE1241 7.6e-57 226.5 Nitrospirae Bacteria 2ETP6@1,33M6W@2,3J18I@40117 NA|NA|NA MAG.T1.5_01492 330214.NIDE1240 1.1e-46 192.2 Bacteria Bacteria COG2768@1,COG2768@2 NA|NA|NA MAG.T1.5_01494 330214.NIDE1238 7.4e-132 476.9 Bacteria crtB GO:0003674,GO:0003824,GO:0004337,GO:0004659,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016108,GO:0016109,GO:0016114,GO:0016116,GO:0016117,GO:0016740,GO:0016765,GO:0016767,GO:0042440,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046148,GO:0071704,GO:1901576 2.5.1.21,2.5.1.32,2.5.1.96,2.5.1.99 ko:K00801,ko:K02291,ko:K10208 ko00100,ko00906,ko00909,ko01062,ko01100,ko01110,ko01130,map00100,map00906,map00909,map01062,map01100,map01110,map01130 M00097 R00702,R02065,R02872,R04218,R06223,R07270,R07652,R09793,R10177 RC00362,RC00796,RC01101,RC02839,RC02869 ko00000,ko00001,ko00002,ko01000,ko01006 Bacteria COG1562@1,COG1562@2 NA|NA|NA I ergosterol biosynthetic process MAG.T1.5_01495 330214.NIDE1237 6.3e-49 200.3 Bacteria ko:K14588 ko00000 Bacteria COG4454@1,COG4454@2 NA|NA|NA MAG.T1.5_01496 330214.NIDE1236 3.8e-157 560.8 Nitrospirae htpX ko:K03799 M00743 ko00000,ko00002,ko01000,ko01002 Bacteria 3J0QG@40117,COG0501@1,COG0501@2 NA|NA|NA O Peptidase family M48 MAG.T1.5_01497 330214.NIDE1235 2.4e-86 325.1 Bacteria btuE 1.11.1.22,1.11.1.9 ko:K00432,ko:K20207 ko00480,ko00590,ko04918,map00480,map00590,map04918 R00274,R07034,R07035 RC00011,RC00982 ko00000,ko00001,ko01000 iJN678.slr1992 Bacteria COG0386@1,COG0386@2 NA|NA|NA O Belongs to the glutathione peroxidase family MAG.T1.5_01500 330214.NIDE1232 1e-201 709.5 Bacteria lacY ko:K02532,ko:K05820,ko:K08167,ko:K08218,ko:K08369 ko01501,map01501 M00628,M00713,M00714 ko00000,ko00001,ko00002,ko01504,ko02000 2.A.1,2.A.1.25,2.A.1.27,2.A.1.3,2.A.1.5 Bacteria COG2807@1,COG2807@2 NA|NA|NA P transmembrane transport MAG.T1.5_01502 330214.NIDE1230 1.9e-61 241.9 Nitrospirae yqeY ko:K09117 ko00000 Bacteria 3J1F3@40117,COG1610@1,COG1610@2 NA|NA|NA S Yqey-like protein MAG.T1.5_01503 330214.NIDE1229 1.9e-99 368.6 Bacteria 3.1.3.3 ko:K03413,ko:K07315 ko02020,ko02030,map02020,map02030 M00506 ko00000,ko00001,ko00002,ko01000,ko02022,ko02035,ko03021 Bacteria COG3437@1,COG3437@2 NA|NA|NA T response regulator, receiver MAG.T1.5_01504 330214.NIDE1228 1.3e-182 645.6 Nitrospirae Bacteria 3J188@40117,COG2199@1,COG3706@2 NA|NA|NA T diguanylate cyclase MAG.T1.5_01505 330214.NIDE1227 2.4e-269 934.5 Bacteria 2.7.13.3 ko:K20973 ko02020,ko02025,map02020,map02025 M00820 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria COG0642@1,COG0642@2,COG0784@1,COG0784@2 NA|NA|NA T Histidine kinase MAG.T1.5_01506 330214.NIDE1226 2.9e-27 127.9 Bacteria Bacteria COG2198@1,COG2198@2 NA|NA|NA T Histidine kinase MAG.T1.5_01507 330214.NIDE1563 1.8e-206 725.3 Bacteria cpxA 2.7.13.3 ko:K02484,ko:K07640,ko:K07643,ko:K07645,ko:K07649,ko:K19609 ko01503,ko02020,ko02024,map01503,map02020,map02024 M00447,M00451,M00453,M00457,M00721,M00722,M00727,M00728,M00770 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria COG5002@1,COG5002@2 NA|NA|NA T protein histidine kinase activity MAG.T1.5_01508 330214.NIDE1562 4.3e-105 387.5 Nitrospirae Bacteria 3J11I@40117,COG0745@1,COG0745@2 NA|NA|NA K Transcriptional regulatory protein, C terminal MAG.T1.5_01509 330214.NIDE1561 1.5e-56 226.1 Bacteria Bacteria COG0438@1,COG0438@2 NA|NA|NA M transferase activity, transferring glycosyl groups MAG.T1.5_01510 272134.KB731326_gene351 1.1e-77 297.0 Oscillatoriales 5.1.3.2 ko:K01784,ko:K20534 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000,ko01005,ko02000 4.D.2.1.9 GT2 Bacteria 1G3KY@1117,1HBRG@1150,COG0451@1,COG0451@2 NA|NA|NA GM NAD dependent epimerase dehydratase family MAG.T1.5_01513 330214.NIDE1225 3.5e-99 367.9 Nitrospirae purN 2.1.2.2,6.3.2.6,6.3.4.13 ko:K11175,ko:K13713 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04144,R04325,R04326,R04591 RC00026,RC00064,RC00090,RC00162,RC00166,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS04225 Bacteria 3J0MC@40117,COG0299@1,COG0299@2 NA|NA|NA F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate MAG.T1.5_01514 330214.NIDE1224 2.2e-177 628.2 Nitrospirae purM GO:0003674,GO:0003824,GO:0004641,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.1,6.3.4.13 ko:K01933,ko:K11788 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144,R04208 RC00090,RC00166,RC01100 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1844,iECSF_1327.ECSF_2340 Bacteria 3J0DR@40117,COG0150@1,COG0150@2 NA|NA|NA F AIR synthase related protein, N-terminal domain MAG.T1.5_01515 330214.NIDE1223 1.2e-242 845.5 Nitrospirae ntrX ko:K02481,ko:K13599 ko02020,map02020 M00498 ko00000,ko00001,ko00002,ko02022 Bacteria 3J0C2@40117,COG2204@1,COG2204@2 NA|NA|NA T Bacterial regulatory protein, Fis family MAG.T1.5_01516 330214.NIDE1222 0.0 1429.8 Nitrospirae ntrY GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.13.3 ko:K13598 ko02020,map02020 M00498 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 3J0B7@40117,COG5000@1,COG5000@2 NA|NA|NA T GHKL domain MAG.T1.5_01517 330214.NIDE1221 4e-53 214.2 Bacteria Bacteria 2EAFJ@1,334IY@2 NA|NA|NA S Domain of unknown function (DUF1844) MAG.T1.5_01518 330214.NIDE1220 9.4e-124 449.9 Nitrospirae mazG GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.6.1.66,3.6.1.9 ko:K02428,ko:K02499,ko:K04765 ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100 R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R01855,R02100,R02720,R03004,R03036,R03531,R11323 RC00002 ko00000,ko00001,ko01000,ko03036 iJN678.sll1005 Bacteria 3J0Q7@40117,COG1694@1,COG3956@2 NA|NA|NA S MazG nucleotide pyrophosphohydrolase domain MAG.T1.5_01522 330214.NIDE1217 2.2e-247 861.3 Nitrospirae hemY 1.3.3.15,1.3.3.4 ko:K00231 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03222,R04178 RC00885 ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS09325 Bacteria 3J0PQ@40117,COG1232@1,COG1232@2 NA|NA|NA H Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX MAG.T1.5_01523 330214.NIDE1216 7.4e-148 530.0 Nitrospirae hemH GO:0003674,GO:0003824,GO:0004325,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0P9@40117,COG0276@1,COG0276@2 NA|NA|NA H Catalyzes the ferrous insertion into protoporphyrin IX MAG.T1.5_01524 330214.NIDE1215 5.1e-165 587.0 Nitrospirae hemE GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_0016 Bacteria 3J0C3@40117,COG0407@1,COG0407@2 NA|NA|NA H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III MAG.T1.5_01526 330214.NIDE1213 1e-174 619.4 Bacteria desC 1.14.19.1 ko:K00507 ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212 R02222 RC00917 ko00000,ko00001,ko01000,ko01004 Bacteria COG1398@1,COG1398@2 NA|NA|NA I oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water MAG.T1.5_01528 330214.NIDE1211 8.4e-125 453.4 Bacteria ydeD Bacteria COG0697@1,COG0697@2 NA|NA|NA EG spore germination MAG.T1.5_01531 330214.NIDE1208 4.9e-48 196.8 Bacteria Bacteria COG2331@1,COG2331@2 NA|NA|NA P Regulatory protein, FmdB family MAG.T1.5_01532 330214.NIDE1207 8.2e-127 459.9 Bacteria pstS ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 ko00000,ko00001,ko00002,ko02000 3.A.1.7 Bacteria COG0226@1,COG0226@2 NA|NA|NA P phosphate ion binding MAG.T1.5_01534 330214.NIDE1205 1.5e-261 908.3 Nitrospirae pycA 6.3.4.14,6.4.1.1,6.4.1.2,6.4.1.7 ko:K01959,ko:K01961,ko:K20141 ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko01230,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212,map01230 M00082,M00173,M00376,M00620 R00344,R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0YP@40117,COG0439@1,COG0439@2 NA|NA|NA I Biotin carboxylase C-terminal domain MAG.T1.5_01535 330214.NIDE1204 8.2e-311 1072.4 Nitrospirae oadA 2.3.1.12,4.1.1.3,6.4.1.1,6.4.1.7 ko:K00627,ko:K01571,ko:K01960,ko:K02160,ko:K20140 ko00010,ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko01230,map00010,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212,map01230 M00082,M00173,M00307,M00376,M00620 R00209,R00217,R00344,R00742,R02569 RC00004,RC00040,RC00367,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000,ko02000 3.B.1.1.1 iJN746.PP_5346,iLJ478.TM0128 Bacteria 3J10I@40117,COG0511@1,COG0511@2,COG5016@1,COG5016@2 NA|NA|NA C Conserved carboxylase domain MAG.T1.5_01536 330214.NIDE1203 6.1e-136 490.3 Bacteria 3.8.1.5 ko:K01563 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 R05284,R05367,R05368,R05369,R05370,R07669,R07670 RC01317,RC01340,RC01341,RC02013 ko00000,ko00001,ko01000 Bacteria COG0596@1,COG0596@2 NA|NA|NA S hydrolase activity, acting on ester bonds MAG.T1.5_01537 330214.NIDE1202 6.9e-103 380.2 Bacteria tpx 1.11.1.15 ko:K11065 ko00000,ko01000 Bacteria COG2077@1,COG2077@2 NA|NA|NA O thioredoxin peroxidase activity MAG.T1.5_01538 330214.NIDE1201 3.4e-248 864.0 Nitrospirae sthA GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.6.1.1 ko:K00322 ko00760,ko01100,map00760,map01100 R00112 RC00001 ko00000,ko00001,ko01000 Bacteria 3J0IM@40117,COG1249@1,COG1249@2 NA|NA|NA C Evidence 2a Function of homologous gene experimentally demonstrated in an other organism MAG.T1.5_01539 330214.NIDE1200 1.2e-123 449.1 Bacteria tenA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 3.5.99.2 ko:K03707 ko00730,ko01100,map00730,map01100 R02133,R09993 RC00224,RC00652,RC02832 ko00000,ko00001,ko01000,ko03000 Bacteria COG0819@1,COG0819@2 NA|NA|NA K Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway MAG.T1.5_01542 118166.JH976537_gene2419 1.2e-80 306.6 Cyanobacteria Bacteria 1G5MR@1117,28NY3@1,2ZBVC@2 NA|NA|NA MAG.T1.5_01543 330214.NIDE1198 4.4e-85 321.6 Bacteria Bacteria COG1413@1,COG1413@2 NA|NA|NA C deoxyhypusine monooxygenase activity MAG.T1.5_01545 1499967.BAYZ01000021_gene207 2e-07 63.5 Bacteria Bacteria 2DSRS@1,33H75@2 NA|NA|NA S Curli production assembly/transport component CsgG MAG.T1.5_01546 330214.NIDE1195 2.7e-127 461.5 Nitrospirae thiD 2.5.1.3,2.7.1.49,2.7.4.7,4.1.99.17 ko:K00941,ko:K03147,ko:K14153 ko00730,ko01100,map00730,map01100 M00127 R03223,R03471,R03472,R04509,R10712 RC00002,RC00017,RC00224,RC03251,RC03252,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2909 Bacteria 3J0RM@40117,COG0351@1,COG0351@2 NA|NA|NA H Phosphomethylpyrimidine kinase MAG.T1.5_01548 330214.NIDE1193 4.3e-112 411.0 Bacteria ko:K06889,ko:K07397 ko00000 Bacteria COG1073@1,COG1073@2 NA|NA|NA S thiolester hydrolase activity MAG.T1.5_01549 330214.NIDE1191 2.1e-186 659.1 Bacteria ko:K20276 ko02024,map02024 ko00000,ko00001 Bacteria COG4733@1,COG4733@2 NA|NA|NA S cellulase activity MAG.T1.5_01550 330214.NIDE1190 1.1e-111 409.8 Nitrospirae Bacteria 3J14J@40117,COG1262@1,COG1262@2 NA|NA|NA S Evidence 4 Homologs of previously reported genes of MAG.T1.5_01551 330214.NIDE1189 1.3e-106 392.5 Bacteria Bacteria COG0500@1,COG2226@2 NA|NA|NA Q methyltransferase MAG.T1.5_01552 330214.NIDE1188 1.6e-61 242.3 Bacteria Bacteria COG2258@1,COG2258@2 NA|NA|NA C MOSC domain MAG.T1.5_01553 330214.NIDE1187 6.7e-133 480.3 Nitrospirae prmA ko:K02687 ko00000,ko01000,ko03009 Bacteria 3J1B7@40117,COG2264@1,COG2264@2 NA|NA|NA J Ribosomal protein L11 methyltransferase (PrmA) MAG.T1.5_01554 330214.NIDE1186 5.1e-278 963.4 Bacteria mutS ko:K03555 ko03430,map03430 ko00000,ko00001,ko03400 Bacteria COG0249@1,COG0249@2 NA|NA|NA L mismatched DNA binding MAG.T1.5_01555 330214.NIDE1185 0.0 1978.0 Nitrospirae aas 2.3.1.40,6.2.1.20 ko:K05939 ko00071,ko00564,map00071,map00564 R01406,R04864 RC00014,RC00039,RC00041 ko00000,ko00001,ko01000 Bacteria 3J17I@40117,COG0204@1,COG0204@2,COG0318@1,COG0318@2,COG0477@1,COG2814@2 NA|NA|NA I Phosphate acyltransferases MAG.T1.5_01556 330214.NIDE1184 2.3e-163 581.6 Bacteria Bacteria COG2159@1,COG2159@2 NA|NA|NA E amidohydrolase MAG.T1.5_01557 330214.NIDE1183 8e-72 276.6 Bacteria ko:K03088 ko00000,ko03021 Bacteria COG1595@1,COG1595@2 NA|NA|NA K DNA-templated transcription, initiation MAG.T1.5_01558 330214.NIDE1182 2.7e-92 345.9 Bacteria Bacteria 2E7Z1@1,332DD@2 NA|NA|NA MAG.T1.5_01560 153948.NAL212_1039 1.2e-29 136.7 Nitrosomonadales Bacteria 1RK5Z@1224,2BP06@1,2WBIA@28216,32HQG@2,3736M@32003 NA|NA|NA MAG.T1.5_01561 330214.NIDE1172 2.2e-109 402.1 Bacteria nqrB GO:0000166,GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008144,GO:0008150,GO:0008152,GO:0010181,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0019842,GO:0030001,GO:0030964,GO:0032553,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044425,GO:0044464,GO:0048037,GO:0050136,GO:0050662,GO:0051179,GO:0051234,GO:0055114,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:1901265,GO:1901363,GO:1902444,GO:1902494 1.6.5.8 ko:K00347,ko:K21163 ko01059,ko01130,map01059,map01130 M00824 ko00000,ko00001,ko00002,ko01000 Bacteria COG1805@1,COG1805@2,COG4402@1,COG4402@2 NA|NA|NA S Uncharacterized protein conserved in bacteria (DUF2330) MAG.T1.5_01562 330214.NIDE1172 4.5e-207 727.2 Bacteria nqrB GO:0000166,GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008144,GO:0008150,GO:0008152,GO:0010181,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0019842,GO:0030001,GO:0030964,GO:0032553,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044425,GO:0044464,GO:0048037,GO:0050136,GO:0050662,GO:0051179,GO:0051234,GO:0055114,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:1901265,GO:1901363,GO:1902444,GO:1902494 1.6.5.8 ko:K00347,ko:K21163 ko01059,ko01130,map01059,map01130 M00824 ko00000,ko00001,ko00002,ko01000 Bacteria COG1805@1,COG1805@2,COG4402@1,COG4402@2 NA|NA|NA S Uncharacterized protein conserved in bacteria (DUF2330) MAG.T1.5_01565 330214.NIDE1168 9.7e-131 473.0 Bacteria Bacteria COG0589@1,COG0589@2 NA|NA|NA T AMP binding MAG.T1.5_01566 330214.NIDE1167 0.0 2464.5 Bacteria lhr ko:K03724 ko00000,ko01000,ko03400 Bacteria COG1201@1,COG1201@2 NA|NA|NA L RNA secondary structure unwinding MAG.T1.5_01568 330214.NIDE1165 1e-61 242.7 Bacteria Bacteria COG2197@1,COG2197@2 NA|NA|NA K response regulator MAG.T1.5_01569 330214.NIDE1164 1.3e-108 399.1 Bacteria ko:K02282 ko00000,ko02035,ko02044 Bacteria COG2197@1,COG2197@2 NA|NA|NA K response regulator MAG.T1.5_01570 330214.NIDE1163 1.2e-160 572.8 Bacteria 2.7.13.3 ko:K07683 ko02020,map02020 M00483 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria COG4585@1,COG4585@2 NA|NA|NA T Histidine kinase MAG.T1.5_01571 330214.NIDE1162 1e-100 373.2 Bacteria yeeZ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 1.5.5.1 ko:K00311 ko00000,ko01000 Bacteria COG0451@1,COG0451@2 NA|NA|NA GM ADP-glyceromanno-heptose 6-epimerase activity MAG.T1.5_01572 330214.NIDE3333 4.6e-71 274.2 Nitrospirae Bacteria 3J0VE@40117,COG1396@1,COG1396@2,COG1917@1,COG1917@2 NA|NA|NA K Cupin domain MAG.T1.5_01573 330214.NIDE1161 3.3e-235 820.8 Bacteria 1.16.3.1 ko:K03594,ko:K07052 ko00860,map00860 R00078 RC02758 ko00000,ko00001,ko01000 Bacteria COG1266@1,COG1266@2,COG1633@1,COG1633@2 NA|NA|NA S Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) MAG.T1.5_01574 330214.NIDE1160 3.1e-170 604.7 Nitrospirae spt 2.6.1.44,2.6.1.45,2.6.1.51 ko:K00830 ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146 M00346,M00532 R00369,R00372,R00585,R00588 RC00006,RC00008,RC00018 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 3J0FC@40117,COG0075@1,COG0075@2 NA|NA|NA E Evidence 2b Function of strongly homologous gene MAG.T1.5_01575 330214.NIDE1159 4.5e-106 390.6 Bacteria ko:K03406 ko02020,ko02030,map02020,map02030 ko00000,ko00001,ko02035 Bacteria COG4191@1,COG4191@2 NA|NA|NA T Histidine kinase MAG.T1.5_01576 330214.NIDE1157 2.7e-187 661.4 Bacteria Bacteria COG1228@1,COG1228@2 NA|NA|NA Q imidazolonepropionase activity MAG.T1.5_01577 330214.NIDE1156 1.6e-102 379.0 Bacteria dnaJ2 ko:K03686,ko:K05516 ko00000,ko03029,ko03036,ko03110 Bacteria COG0484@1,COG0484@2 NA|NA|NA O heat shock protein binding MAG.T1.5_01578 330214.NIDE1155 2.4e-205 721.5 Nitrospirae Bacteria 3J171@40117,COG0477@1,COG2814@2 NA|NA|NA EGP Sugar (and other) transporter MAG.T1.5_01579 330214.NIDE1154 9.6e-70 270.0 Bacteria kipI 3.5.1.54 ko:K01457,ko:K06351,ko:K07160 ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120 R00005 RC02756 ko00000,ko00001,ko01000 Bacteria COG2049@1,COG2049@2 NA|NA|NA E 5-oxoprolinase (ATP-hydrolyzing) activity MAG.T1.5_01580 330214.NIDE1153 1.5e-98 365.9 Bacteria ybgL ko:K07160 ko00000 Bacteria COG1540@1,COG1540@2 NA|NA|NA S 5-oxoprolinase (ATP-hydrolyzing) activity MAG.T1.5_01581 330214.NIDE1152 5.3e-125 454.1 Bacteria kipA 3.5.1.54,6.3.4.6 ko:K01457,ko:K01941,ko:K06350 ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120 R00005,R00774 RC00378,RC02756 ko00000,ko00001,ko01000 Bacteria COG1984@1,COG1984@2 NA|NA|NA E allophanate hydrolase subunit 2 MAG.T1.5_01583 330214.NIDE1150 0.0 1408.7 Nitrospirae cca 2.7.7.19,2.7.7.72,3.1.13.3,3.1.3.7 ko:K00970,ko:K00974,ko:K06881 ko00920,ko01100,ko01120,ko03013,ko03018,map00920,map01100,map01120,map03013,map03018 R00188,R00508,R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016,ko03019,ko03400 Bacteria 3J0NX@40117,COG0517@1,COG0517@2,COG0617@1,COG0617@2,COG0618@1,COG0618@2 NA|NA|NA J Probable RNA and SrmB- binding site of polymerase A MAG.T1.5_01584 330214.NIDE1149 2.6e-23 115.5 Bacteria Bacteria 2EIBB@1,33C2R@2 NA|NA|NA MAG.T1.5_01585 330214.NIDE1145 4e-92 344.7 Bacteria merA Bacteria COG0398@1,COG0398@2 NA|NA|NA M Pfam SNARE associated Golgi protein MAG.T1.5_01588 330214.NIDE1143 1.1e-115 422.5 Bacteria yuiH Bacteria COG2041@1,COG2041@2 NA|NA|NA V Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide MAG.T1.5_01589 330214.NIDE1142 3.1e-169 601.3 Bacteria GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0046872,GO:0071704,GO:1901564 5.1.1.20 ko:K19802 R10938 RC03309 ko00000,ko01000 Bacteria COG4948@1,COG4948@2 NA|NA|NA M carboxylic acid catabolic process MAG.T1.5_01591 330214.NIDE1139 6.8e-36 156.0 Bacteria Bacteria COG1670@1,COG1670@2 NA|NA|NA J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins MAG.T1.5_01592 330214.NIDE1138 3.8e-133 481.1 Nitrospirae 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 R05066 RC00099 ko00000,ko00001,ko01000 Bacteria 3J0YI@40117,COG2084@1,COG2084@2 NA|NA|NA C NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase MAG.T1.5_01594 330214.NIDE1136 2.4e-74 285.0 Bacteria hbpS ko:K11477 ko00000 Bacteria COG3193@1,COG3193@2 NA|NA|NA MAG.T1.5_01596 330214.NIDE1132 0.0 1113.6 Bacteria glgX Bacteria COG3408@1,COG3408@2 NA|NA|NA G Glycogen debranching enzyme MAG.T1.5_01597 330214.NIDE1131 0.0 1710.3 Bacteria ko:K22110 ko00000,ko02000 1.B.35.1,1.B.35.2 Bacteria COG1452@1,COG1452@2 NA|NA|NA M lipopolysaccharide transport MAG.T1.5_01599 330214.NIDE1129 9.5e-165 586.3 Bacteria Bacteria COG4677@1,COG4677@2 NA|NA|NA G pectinesterase activity MAG.T1.5_01600 330214.NIDE1128 7.6e-82 310.1 Nitrospirae coaE 2.7.1.24,6.3.4.4 ko:K00859,ko:K01939 ko00230,ko00250,ko00770,ko01100,map00230,map00250,map00770,map01100 M00049,M00120 R00130,R01135 RC00002,RC00078,RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0RK@40117,COG0237@1,COG0237@2 NA|NA|NA H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A MAG.T1.5_01601 330214.NIDE1127 1.6e-147 528.9 Nitrospirae trxB GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.9,4.3.1.9 ko:K00384,ko:K03671,ko:K22345 ko00030,ko00450,ko04621,ko05418,map00030,map00450,map04621,map05418 R01544,R02016,R03596,R09372 RC00013,RC00544,RC02518,RC02873 ko00000,ko00001,ko01000,ko03110 iNJ661.Rv3913,iPC815.YPO1374 Bacteria 3J0M0@40117,COG0492@1,COG0492@2 NA|NA|NA C Pyridine nucleotide-disulphide oxidoreductase MAG.T1.5_01602 717231.Flexsi_1740 1.4e-25 122.5 Bacteria Bacteria 2DNS7@1,32YWC@2 NA|NA|NA S S23 ribosomal protein MAG.T1.5_01603 330214.NIDE1125 1.1e-196 692.6 Bacteria thiI GO:0000049,GO:0002937,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0017144,GO:0018130,GO:0019438,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042364,GO:0042723,GO:0042724,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.8.1.4 ko:K03151 ko00730,ko01100,ko04122,map00730,map01100,map04122 R07461 ko00000,ko00001,ko01000,ko03016 iECNA114_1301.ECNA114_0400,iECO26_1355.ECO26_0455,iECSF_1327.ECSF_0383,iSDY_1059.SDY_0307 Bacteria COG0301@1,COG0301@2 NA|NA|NA H tRNA thio-modification MAG.T1.5_01604 330214.NIDE1124 1e-73 283.1 Bacteria sppD 2.3.1.235 ko:K05554,ko:K14670,ko:K15886 ko01056,ko01057,ko01130,map01056,map01057,map01130 M00778,M00783 R06701,R09265,R09269,R10960 RC00392,RC02496,RC02546 ko00000,ko00001,ko00002,ko01000,ko01004,ko01008 Bacteria COG2867@1,COG2867@2 NA|NA|NA I negative regulation of translational initiation MAG.T1.5_01605 1173026.Glo7428_3883 1.1e-51 210.3 Bacteria Bacteria COG0784@1,COG0784@2,COG5002@1,COG5002@2 NA|NA|NA T Response regulator, receiver MAG.T1.5_01607 330214.NIDE1121 4e-144 517.7 Nitrospirae queG GO:0003674,GO:0003824,GO:0006091,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009055,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0022900,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 ko:K18979 ko00000,ko01000,ko03016 Bacteria 3J19A@40117,COG1600@1,COG1600@2 NA|NA|NA C Domain of unknown function (DUF1730) MAG.T1.5_01608 330214.NIDE1120 1.3e-228 798.9 Bacteria ko:K02481,ko:K07714 ko02020,map02020 M00500 ko00000,ko00001,ko00002,ko02022 Bacteria COG2204@1,COG2204@2 NA|NA|NA T phosphorelay signal transduction system MAG.T1.5_01609 330214.NIDE1119 4.5e-261 907.1 Bacteria 2.7.13.3 ko:K02482 ko00000,ko01000,ko01001,ko02022 Bacteria COG4191@1,COG4191@2 NA|NA|NA T Histidine kinase MAG.T1.5_01610 330214.NIDE1118 2.7e-136 491.5 Nitrospirae Bacteria 3J193@40117,COG4783@1,COG4783@2 NA|NA|NA S Peptidase family M48 MAG.T1.5_01611 330214.NIDE1117 3.5e-67 261.2 Bacteria Bacteria 2EKQ4@1,33EDV@2 NA|NA|NA S Bacterial SH3 domain homologues MAG.T1.5_01612 330214.NIDE1116 0.0 1171.4 Nitrospirae 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0XC@40117,COG2114@1,COG2114@2,COG4252@1,COG4252@2 NA|NA|NA T Adenylate cyclase MAG.T1.5_01613 330214.NIDE1115 1.9e-244 851.7 Bacteria 1.14.99.50 ko:K18912 ko00340,map00340 R11013 RC03323,RC03324 ko00000,ko00001,ko01000 Bacteria COG0265@1,COG0265@2,COG1262@1,COG1262@2 NA|NA|NA T PFAM Formylglycine-generating sulfatase enzyme MAG.T1.5_01614 330214.NIDE1114 2.8e-92 345.1 Bacteria gspA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 ko:K02450 M00331 ko00000,ko00002,ko02044 9.B.42 Bacteria COG3267@1,COG3267@2 NA|NA|NA MAG.T1.5_01618 330214.NIDE1110 2e-91 342.0 Bacteria narP ko:K02479,ko:K07685 ko02020,map02020 M00472 ko00000,ko00001,ko00002,ko02022 Bacteria COG2197@1,COG2197@2 NA|NA|NA K response regulator MAG.T1.5_01619 330214.NIDE3284 6.9e-38 166.0 Nitrospirae 2.7.13.3 ko:K02482,ko:K14986 ko02020,map02020 M00524 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 3J117@40117,COG3829@1,COG3829@2,COG4191@1,COG4191@2,COG5000@1,COG5000@2 NA|NA|NA T His Kinase A (phosphoacceptor) domain MAG.T1.5_01620 330214.NIDE1108 0.0 1277.3 Nitrospirae mutS2 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 ko:K07456 ko03430,map03430 ko00000,ko00001,ko03400 Bacteria 3J0Y0@40117,COG1193@1,COG1193@2 NA|NA|NA L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity MAG.T1.5_01621 330214.NIDE1107 2.3e-179 634.8 Nitrospirae gap 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 Bacteria 3J0D8@40117,COG0057@1,COG0057@2 NA|NA|NA C Belongs to the glyceraldehyde-3-phosphate dehydrogenase family MAG.T1.5_01622 330214.NIDE1106 2.1e-219 768.1 Nitrospirae pgk GO:0003674,GO:0003824,GO:0004618,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.2.3,5.3.1.1 ko:K00927,ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01015,R01512 RC00002,RC00043,RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 3J0DE@40117,COG0126@1,COG0126@2 NA|NA|NA G Phosphoglycerate kinase MAG.T1.5_01623 330214.NIDE1105 9.3e-112 409.8 Nitrospirae tpiA GO:0003674,GO:0003824,GO:0004807,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 iJN746.PP_4715 Bacteria 3J0MW@40117,COG0149@1,COG0149@2 NA|NA|NA G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) MAG.T1.5_01624 330214.NIDE1104 2.6e-45 188.0 Nitrospirae secG GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 Bacteria 3J0V0@40117,COG1314@1,COG1314@2 NA|NA|NA U Preprotein translocase SecG subunit MAG.T1.5_01625 330214.NIDE1103 8.2e-157 559.7 Nitrospirae ilvE 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 3J0BM@40117,COG0115@1,COG0115@2 NA|NA|NA E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family MAG.T1.5_01626 330214.NIDE1102 4.2e-47 193.7 Nitrospirae rplU GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02888 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0TM@40117,COG0261@1,COG0261@2 NA|NA|NA J This protein binds to 23S rRNA in the presence of protein L20 MAG.T1.5_01627 330214.NIDE1101 1.7e-41 174.9 Nitrospirae rpmA GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904 ko:K02899 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0RB@40117,COG0211@1,COG0211@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL27 family MAG.T1.5_01628 330214.NIDE1100 1.9e-165 588.6 Nitrospirae obg GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0007059,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0022607,GO:0022611,GO:0022613,GO:0022618,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0042254,GO:0042255,GO:0043021,GO:0043023,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0065003,GO:0065007,GO:0070925,GO:0071826,GO:0071840,GO:0090069,GO:0090071,GO:0097159,GO:0097367,GO:1901265,GO:1901363 ko:K03979 ko00000,ko01000,ko03009 Bacteria 3J0E3@40117,COG0536@1,COG0536@2 NA|NA|NA S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control MAG.T1.5_01629 330214.NIDE1099 1.4e-177 629.0 Nitrospirae proB GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_3198 Bacteria 3J0GU@40117,COG0263@1,COG0263@2 NA|NA|NA E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate MAG.T1.5_01630 330214.NIDE1098 6.8e-95 353.6 Nitrospirae nadD GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18,3.6.1.55 ko:K00969,ko:K03574 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 iAF987.Gmet_3200 Bacteria 3J0T3@40117,COG1057@1,COG1057@2 NA|NA|NA H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) MAG.T1.5_01631 330214.NIDE1097 7.1e-58 229.9 Nitrospirae rsfS GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113 2.7.7.18 ko:K00969,ko:K09710 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000,ko03009 Bacteria 3J0UC@40117,COG0799@1,COG0799@2 NA|NA|NA J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation MAG.T1.5_01632 330214.NIDE1096 2.3e-214 751.5 Nitrospirae ko:K19804 ko00000 Bacteria 3J0KC@40117,COG2956@1,COG2956@2 NA|NA|NA G Tetratricopeptide repeat MAG.T1.5_01633 330214.NIDE1095 1.8e-179 635.2 Nitrospirae bioB 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 iYO844.BSU30200 Bacteria 3J0I9@40117,COG0502@1,COG0502@2 NA|NA|NA H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism MAG.T1.5_01634 330214.NIDE1094 0.0 1176.0 Nitrospirae salY ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 3J0Z3@40117,COG0577@1,COG0577@2 NA|NA|NA V MacB-like periplasmic core domain MAG.T1.5_01635 330214.NIDE1093 3.7e-33 147.5 Bacteria Bacteria COG2197@1,COG2197@2 NA|NA|NA K response regulator MAG.T1.5_01636 330214.NIDE1091 1.3e-157 562.4 Nitrospirae pyrD GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.98.1 ko:K00226,ko:K02823,ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01867,R01869 RC00051 ko00000,ko00001,ko00002,ko01000 Bacteria 3J145@40117,COG0167@1,COG0167@2 NA|NA|NA F Catalyzes the conversion of dihydroorotate to orotate MAG.T1.5_01637 330214.NIDE1090 1.7e-101 375.6 Bacteria ko:K02003 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria COG1136@1,COG1136@2 NA|NA|NA V lipoprotein transporter activity MAG.T1.5_01638 330214.NIDE1089 2.7e-106 391.7 Nitrospirae comF 2.4.2.14 ko:K00764,ko:K02242 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00429 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002,ko02044 Bacteria 3J19P@40117,COG1040@1,COG1040@2 NA|NA|NA S Phosphoribosyl transferase domain MAG.T1.5_01639 330214.NIDE1088 6.2e-36 156.8 Bacteria Bacteria COG2331@1,COG2331@2 NA|NA|NA P Regulatory protein, FmdB family MAG.T1.5_01640 330214.NIDE1087 7.3e-74 283.1 Nitrospirae mraZ GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0040007,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 ko:K03925 ko00000 Bacteria 3J0VQ@40117,COG2001@1,COG2001@2 NA|NA|NA K MraZ protein, putative antitoxin-like MAG.T1.5_01641 330214.NIDE1086 3.9e-55 221.5 Bacteria rusA 3.1.22.4 ko:K01160 ko00000,ko01000,ko03400 Bacteria COG4570@1,COG4570@2 NA|NA|NA L crossover junction endodeoxyribonuclease activity MAG.T1.5_01642 330214.NIDE1085 2.4e-186 658.3 Nitrospirae Bacteria 3J14V@40117,COG2206@1,COG2206@2 NA|NA|NA T Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_01643 330214.NIDE1084 1.9e-199 701.8 Nitrospirae salY ko:K02004,ko:K05685 ko02010,map02010 M00258,M00709 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.122.1,3.A.1.122.12 Bacteria 3J0EW@40117,COG0577@1,COG0577@2 NA|NA|NA V MacB-like periplasmic core domain MAG.T1.5_01644 330214.NIDE1083 2.1e-115 421.8 Nitrospirae macB ko:K02003,ko:K05685 ko02010,map02010 M00258,M00709 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.122.1,3.A.1.122.12 Bacteria 3J10N@40117,COG1136@1,COG1136@2 NA|NA|NA V Evidence 2b Function of strongly homologous gene MAG.T1.5_01645 330214.NIDE1082 1.7e-179 635.6 Nitrospirae macA_1 ko:K02005,ko:K13888 M00709 ko00000,ko00002,ko02000 8.A.1 Bacteria 3J0HQ@40117,COG0845@1,COG0845@2 NA|NA|NA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family MAG.T1.5_01646 330214.NIDE1081 9.8e-100 369.8 Bacteria comEA ko:K02237 M00429 ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 Bacteria COG1196@1,COG1196@2,COG1555@1,COG1555@2 NA|NA|NA L photosystem II stabilization MAG.T1.5_01647 330214.NIDE1080 2.6e-139 501.5 Nitrospirae uppP GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016311,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0031224,GO:0031226,GO:0042221,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050380,GO:0050896,GO:0071944 3.6.1.27 ko:K06153 ko00550,map00550 R05627 RC00002 ko00000,ko00001,ko01000,ko01011 iYL1228.KPN_03461 Bacteria 3J0S7@40117,COG1968@1,COG1968@2 NA|NA|NA V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP) MAG.T1.5_01648 323848.Nmul_A2677 4.5e-10 70.5 Nitrosomonadales Bacteria 1NP57@1224,2W4M7@28216,3320J@2,373I1@32003,arCOG08720@1 NA|NA|NA S Domain of unknown function (DUF2024) MAG.T1.5_01649 330214.NIDE1078 2.1e-75 288.5 Nitrospirae lspA 3.4.23.36 ko:K03101 ko03060,map03060 ko00000,ko00001,ko01000,ko01002 Bacteria 3J0S2@40117,COG0597@1,COG0597@2 NA|NA|NA MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins MAG.T1.5_01650 330214.NIDE1077 0.0 1787.3 Nitrospirae ileS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iG2583_1286.G2583_0027,iPC815.YPO0475 Bacteria 3J0BF@40117,COG0060@1,COG0060@2 NA|NA|NA J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) MAG.T1.5_01652 330214.NIDE1076 1.4e-209 735.3 Nitrospirae nadA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0NV@40117,COG0379@1,COG0379@2 NA|NA|NA H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate MAG.T1.5_01655 1123392.AQWL01000002_gene1831 1.3e-98 367.1 Betaproteobacteria ko:K07001 ko00000 Bacteria 1MUI6@1224,2VHA3@28216,COG1752@1,COG1752@2 NA|NA|NA S Phospholipase, patatin family MAG.T1.5_01656 330214.NIDE1069 1.2e-40 172.2 Bacteria Bacteria 2DJBU@1,32UCQ@2 NA|NA|NA MAG.T1.5_01657 330214.NIDE1068 1e-70 272.7 Bacteria VY92_01935 Bacteria COG0454@1,COG0456@2 NA|NA|NA K acetyltransferase MAG.T1.5_01658 330214.NIDE1067 0.0 1434.9 Bacteria Bacteria 2DBJW@1,2Z9P2@2 NA|NA|NA MAG.T1.5_01661 330214.NIDE2812 2.6e-74 285.0 Bacteria ko:K03406 ko02020,ko02030,map02020,map02030 ko00000,ko00001,ko02035 Bacteria COG4191@1,COG4191@2 NA|NA|NA T Histidine kinase MAG.T1.5_01662 330214.NIDE1063 0.0 1239.9 Nitrospirae thiC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 iECABU_c1320.ECABU_c45100 Bacteria 3J0AY@40117,COG0422@1,COG0422@2 NA|NA|NA H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction MAG.T1.5_01663 330214.NIDE1062 2.9e-145 521.2 Bacteria thi4 GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0018131,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046484,GO:0046872,GO:0046914,GO:0052837,GO:0052838,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 ko:K03146 ko00730,ko01100,map00730,map01100 R10685 RC00033,RC03253,RC03254 ko00000,ko00001 Bacteria COG1635@1,COG1635@2 NA|NA|NA H Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur MAG.T1.5_01664 330214.NIDE1061 7.6e-92 343.2 Bacteria sscB Bacteria COG3063@1,COG3063@2 NA|NA|NA NU photosynthesis MAG.T1.5_01665 330214.NIDE1060 2.1e-48 198.4 Bacteria Bacteria COG2199@1,COG3706@2 NA|NA|NA T diguanylate cyclase activity MAG.T1.5_01666 330214.NIDE1059 1.6e-170 605.5 Bacteria gcvT 1.5.99.5,2.1.2.10 ko:K00605,ko:K06980,ko:K22086 ko00260,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200 M00532 R00609,R01221,R02300,R04125 RC00022,RC00069,RC00183,RC00190,RC00557,RC02834 ko00000,ko00001,ko00002,ko01000,ko03016 Bacteria COG0404@1,COG0404@2 NA|NA|NA E The glycine cleavage system catalyzes the degradation of glycine MAG.T1.5_01668 1283299.AUKG01000003_gene644 4.6e-07 60.5 Actinobacteria Bacteria 2CA4F@1,2GRQ2@201174,33DCB@2 NA|NA|NA MAG.T1.5_01670 330214.NIDE1055 1.6e-26 125.6 Bacteria Bacteria COG2197@1,COG2197@2 NA|NA|NA K response regulator MAG.T1.5_01672 330214.NIDE1053 1.1e-46 192.6 Bacteria Bacteria 2FBTK@1,343YA@2 NA|NA|NA MAG.T1.5_01673 330214.NIDE1052 6.1e-72 276.6 Bacteria Bacteria COG4319@1,COG4319@2 NA|NA|NA MAG.T1.5_01674 330214.NIDE1051 1.3e-35 155.6 Bacteria Bacteria COG2197@1,COG2197@2 NA|NA|NA K response regulator MAG.T1.5_01675 330214.NIDE1047 1.3e-233 815.5 Bacteria ko:K02481,ko:K02584,ko:K07712 ko02020,map02020 M00497 ko00000,ko00001,ko00002,ko02022,ko03000 Bacteria COG2204@1,COG2204@2 NA|NA|NA T phosphorelay signal transduction system MAG.T1.5_01676 330214.NIDE1046 0.0 1865.1 Bacteria barA 2.7.13.3 ko:K07636 ko02020,map02020 M00434 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria COG0642@1,COG0784@1,COG0784@2,COG2202@1,COG2202@2,COG2203@1,COG2203@2,COG2205@2,COG4191@1,COG4191@2 NA|NA|NA T PhoQ Sensor MAG.T1.5_01677 330214.NIDE0935 1.1e-81 309.7 Bacteria ko:K02282 ko00000,ko02035,ko02044 Bacteria COG2197@1,COG2197@2 NA|NA|NA K response regulator MAG.T1.5_01678 330214.NIDE0936 1.6e-152 546.2 Nitrospirae Bacteria 3J12P@40117,COG4585@1,COG4585@2 NA|NA|NA T Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_01679 330214.NIDE1043 2.5e-140 505.0 Bacteria yetK Bacteria COG0697@1,COG0697@2 NA|NA|NA EG spore germination MAG.T1.5_01680 330214.NIDE1042 6.8e-100 370.2 Nitrospirae yrrM 2.1.1.104 ko:K00588 ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110 M00039,M00350 R01942,R06578 RC00003,RC00392 ko00000,ko00001,ko00002,ko01000 Bacteria 3J1C3@40117,COG4122@1,COG4122@2 NA|NA|NA S Methyltransferase domain MAG.T1.5_01681 330214.NIDE1041 1.3e-266 925.2 Bacteria ypwA GO:0003674,GO:0003824,GO:0004180,GO:0004181,GO:0005488,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0016787,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.17.19 ko:K01299,ko:K03281 ko00000,ko01000,ko01002 2.A.49 Bacteria COG2317@1,COG2317@2 NA|NA|NA E metallocarboxypeptidase activity MAG.T1.5_01682 330214.NIDE1040 5.9e-84 317.4 Nitrospirae ko:K02282 ko00000,ko02035,ko02044 Bacteria 3J12Q@40117,COG2197@1,COG2197@2 NA|NA|NA K Product type r regulator MAG.T1.5_01685 330214.NIDE1037 2e-77 295.0 Nitrospirae fur GO:0000976,GO:0001067,GO:0001130,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032991,GO:0032993,GO:0042802,GO:0043565,GO:0044212,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141 ko:K03711 ko00000,ko03000 Bacteria 3J0UN@40117,COG0735@1,COG0735@2 NA|NA|NA P Belongs to the Fur family MAG.T1.5_01686 330214.NIDE1036 1.1e-163 582.8 Bacteria fbpA GO:0005575,GO:0005623,GO:0042597,GO:0044464 ko:K02012 ko02010,map02010 M00190 ko00000,ko00001,ko00002,ko02000 3.A.1.10 iJN678.sufA Bacteria COG1840@1,COG1840@2 NA|NA|NA P iron ion homeostasis MAG.T1.5_01687 330214.NIDE1035 2.2e-253 881.3 Bacteria sfuB ko:K02011 ko02010,map02010 M00190 ko00000,ko00001,ko00002,ko02000 3.A.1.10 Bacteria COG1178@1,COG1178@2 NA|NA|NA P thiamine transport MAG.T1.5_01688 330214.NIDE1034 1.9e-169 602.1 Bacteria potA 3.6.3.30 ko:K02010 ko02010,map02010 M00190 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10 Bacteria COG3842@1,COG3842@2 NA|NA|NA P ATPase activity MAG.T1.5_01689 330214.NIDE1033 6.1e-65 253.4 Bacteria exbB GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0017038,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 ko:K03561,ko:K03562 ko01120,map01120 ko00000,ko02000 1.A.30.2.1,1.A.30.2.2 Bacteria COG0811@1,COG0811@2 NA|NA|NA U bacteriocin transport MAG.T1.5_01690 330214.NIDE1032 5e-55 220.3 Bacteria exbD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03559 ko00000,ko02000 1.A.30.2.1 Bacteria COG0848@1,COG0848@2 NA|NA|NA U biopolymer transport protein MAG.T1.5_01691 330214.NIDE1031 3.2e-50 205.7 Nitrospirae ko:K03832 ko00000,ko02000 2.C.1.1 Bacteria 3J0U0@40117,COG0810@1,COG0810@2 NA|NA|NA M Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_01692 330214.NIDE1029 3.8e-135 488.0 Bacteria nosX 2.7.1.180 ko:K03734 ko00000,ko01000 Bacteria COG1477@1,COG1477@2 NA|NA|NA H protein flavinylation MAG.T1.5_01694 330214.NIDE1028 2.7e-266 924.1 Bacteria ko:K12065 ko00000,ko02044 3.A.7.11.1 Bacteria COG2433@1,COG2433@2 NA|NA|NA MAG.T1.5_01696 330214.NIDE1026 2.5e-113 414.8 Bacteria nosR ko:K19339,ko:K19343 ko00000,ko03000 Bacteria COG3901@1,COG3901@2 NA|NA|NA CK FMN binding MAG.T1.5_01697 247490.KSU1_D0875 3.7e-11 75.1 Planctomycetes Bacteria 2A5QB@1,2J3IC@203682,30UF7@2 NA|NA|NA MAG.T1.5_01698 330214.NIDE1024 9e-72 276.9 Bacteria Bacteria COG2206@1,COG2206@2 NA|NA|NA T PFAM metal-dependent phosphohydrolase, HD sub domain MAG.T1.5_01699 330214.NIDE1023 6.9e-51 207.2 Bacteria ko:K07720 ko02020,map02020 M00519 ko00000,ko00001,ko00002,ko02022 Bacteria COG4977@1,COG4977@2 NA|NA|NA K sequence-specific DNA binding MAG.T1.5_01700 330214.NIDE1022 1.9e-70 271.9 Bacteria bfr GO:0003674,GO:0003824,GO:0004322,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016491,GO:0016722,GO:0016724,GO:0019725,GO:0030003,GO:0033212,GO:0033214,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0071944,GO:0098771 1.16.3.1 ko:K03594 ko00860,map00860 R00078 RC02758 ko00000,ko00001,ko01000 Bacteria COG2193@1,COG2193@2 NA|NA|NA P ferroxidase activity MAG.T1.5_01701 330214.NIDE1021 3.6e-79 300.8 Bacteria bfr GO:0003674,GO:0003824,GO:0004322,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016491,GO:0016722,GO:0016724,GO:0019725,GO:0030003,GO:0033212,GO:0033214,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0071944,GO:0098771 1.16.3.1 ko:K03594 ko00860,map00860 R00078 RC02758 ko00000,ko00001,ko01000 Bacteria COG2193@1,COG2193@2 NA|NA|NA P ferroxidase activity MAG.T1.5_01702 330214.NIDE1020 0.0 1458.7 Nitrospirae topA 5.99.1.2 ko:K03168,ko:K07479 ko00000,ko01000,ko03032,ko03400 Bacteria 3J0DN@40117,COG0550@1,COG0550@2,COG0551@1,COG0551@2 NA|NA|NA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone MAG.T1.5_01703 330214.NIDE1019 1.4e-156 559.3 Nitrospirae dprA 5.99.1.2 ko:K03168,ko:K04096 ko00000,ko01000,ko03032,ko03400 Bacteria 3J0Q8@40117,COG0758@1,COG0758@2 NA|NA|NA L DNA recombination-mediator protein A MAG.T1.5_01704 330214.NIDE1018 5.1e-276 956.4 Nitrospirae rng GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008996,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 ko:K08301 ko00000,ko01000,ko03009,ko03019 Bacteria 3J0DK@40117,COG1530@1,COG1530@2 NA|NA|NA J Ribonuclease E/G family MAG.T1.5_01705 330214.NIDE1017 3.3e-195 687.6 Nitrospirae mrdB GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008360,GO:0016020,GO:0022603,GO:0022604,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944 ko:K05837 ko00000,ko03036 Bacteria 3J0IA@40117,COG0772@1,COG0772@2 NA|NA|NA D Peptidoglycan polymerase that is essential for cell wall elongation MAG.T1.5_01706 330214.NIDE1016 0.0 1098.2 Nitrospirae mrdA GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 ko00000,ko00001,ko01000,ko01011 iAF987.Gmet_0928,iEcE24377_1341.EcE24377A_0661,iPC815.YPO2604 Bacteria 3J0FY@40117,COG0768@1,COG0768@2 NA|NA|NA M Penicillin-binding Protein dimerisation domain MAG.T1.5_01707 1121422.AUMW01000007_gene3173 5.9e-11 74.3 Peptococcaceae mreD GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008360,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944 ko:K03571 ko00000,ko03036 9.B.157.1 Bacteria 1V1EJ@1239,24RP5@186801,262R9@186807,COG2891@1,COG2891@2 NA|NA|NA M shape-determining protein MreD MAG.T1.5_01708 330214.NIDE1014 1.5e-147 528.9 Nitrospirae mreC GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007163,GO:0008150,GO:0008360,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0030428,GO:0031224,GO:0031226,GO:0042546,GO:0043621,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071554,GO:0071840,GO:0071944,GO:0071963 ko:K03570 ko00000,ko03036 9.B.157.1 Bacteria 3J0S3@40117,COG1792@1,COG1792@2 NA|NA|NA M shape-determining protein MreC MAG.T1.5_01709 330214.NIDE1013 6.2e-188 663.3 Nitrospirae mreB GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005856,GO:0005886,GO:0007049,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0032505,GO:0042802,GO:0043093,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051301,GO:0051302,GO:0051782,GO:0051983,GO:0065007,GO:0065008,GO:0071944 ko:K03569 ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 Bacteria 3J0BS@40117,COG1077@1,COG1077@2 NA|NA|NA D Actin MAG.T1.5_01710 330214.NIDE1012 3.9e-85 320.9 Nitrospirae Bacteria 3J0U3@40117,COG1714@1,COG1714@2 NA|NA|NA S RDD family MAG.T1.5_01711 330214.NIDE1011 1.5e-116 425.6 Nitrospirae ppiD GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0008150,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031233,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0061077,GO:0071575,GO:0071944,GO:0098552 5.2.1.8 ko:K01802,ko:K03769,ko:K03770 ko00000,ko01000,ko03110 Bacteria 3J1BR@40117,COG0760@1,COG0760@2 NA|NA|NA O SurA N-terminal domain MAG.T1.5_01712 330214.NIDE1010 1.1e-155 556.2 Nitrospirae queA GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009314,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0050896,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.29,2.4.99.17 ko:K00773,ko:K07568 R03789,R10209 RC00063 ko00000,ko01000,ko03016 Bacteria 3J0HB@40117,COG0809@1,COG0809@2 NA|NA|NA J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) MAG.T1.5_01713 330214.NIDE1009 2.7e-184 651.4 Nitrospirae lytB GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 ko:K06381 ko00000 Bacteria 3J15K@40117,COG2385@1,COG2385@2 NA|NA|NA D Stage II sporulation protein MAG.T1.5_01714 330214.NIDE1008 6.4e-30 136.3 Nitrospirae yrzS Bacteria 2DNS1@1,32YVX@2,3J1CZ@40117 NA|NA|NA S Protein of unknown function (DUF2905) MAG.T1.5_01715 330214.NIDE1007 4.5e-175 620.5 Nitrospirae asd GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004073,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006553,GO:0006555,GO:0006566,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009081,GO:0009082,GO:0009085,GO:0009086,GO:0009088,GO:0009089,GO:0009097,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0BR@40117,COG0136@1,COG0136@2 NA|NA|NA E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate MAG.T1.5_01716 330214.NIDE1006 3.4e-185 654.4 Nitrospirae Bacteria 3J19W@40117,COG3391@1,COG3391@2 NA|NA|NA S NHL repeat MAG.T1.5_01717 330214.NIDE1005 2.9e-180 637.9 Nitrospirae leuB GO:0000287,GO:0003674,GO:0003824,GO:0003862,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030145,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034198,GO:0042594,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0071496,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1990928 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 iECs_1301.ECs0077,iYL1228.KPN_00079,iZ_1308.Z0082 Bacteria 3J0JQ@40117,COG0473@1,COG0473@2 NA|NA|NA C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate MAG.T1.5_01718 330214.NIDE1004 2.5e-51 208.0 Bacteria Bacteria COG0662@1,COG0662@2 NA|NA|NA G Cupin 2, conserved barrel domain protein MAG.T1.5_01719 330214.NIDE1002 1.1e-276 958.7 Nitrospirae leuA 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS10690,iYO844.BSU28280 Bacteria 3J0F7@40117,COG0119@1,COG0119@2 NA|NA|NA E Belongs to the alpha-IPM synthase homocitrate synthase family MAG.T1.5_01721 330214.NIDE1001 5.5e-122 443.7 Nitrospirae pssA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0KW@40117,COG1183@1,COG1183@2 NA|NA|NA I CDP-alcohol phosphatidyltransferase MAG.T1.5_01722 330214.NIDE1000 2e-112 411.8 Nitrospirae psd 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0KD@40117,COG0688@1,COG0688@2 NA|NA|NA I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) MAG.T1.5_01723 330214.NIDE0999 1.9e-186 658.3 Nitrospirae ilvC 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS10005,iHN637.CLJU_RS10010,iJN746.PP_4678,iLJ478.TM0550 Bacteria 3J0DW@40117,COG0059@1,COG0059@2 NA|NA|NA H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate MAG.T1.5_01724 330214.NIDE0998 1.9e-84 318.5 Nitrospirae ilvH GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 iAPECO1_1312.APECO1_1906,iECNA114_1301.ECNA114_0072,iEcSMS35_1347.EcSMS35_0084,iG2583_1286.G2583_0082,iSFxv_1172.SFxv_0077,iUTI89_1310.UTI89_C0086 Bacteria 3J0K8@40117,COG0440@1,COG0440@2 NA|NA|NA E ACT domain MAG.T1.5_01725 330214.NIDE0997 0.0 1158.3 Nitrospirae ilvI GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030976,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 iAPECO1_1312.APECO1_1907,iB21_1397.B21_00078,iBWG_1329.BWG_0073,iECBD_1354.ECBD_3539,iECB_1328.ECB_00079,iECD_1391.ECD_00079,iUTI89_1310.UTI89_C0085,iYL1228.KPN_00082 Bacteria 3J0D6@40117,COG0028@1,COG0028@2 NA|NA|NA H Thiamine pyrophosphate enzyme, N-terminal TPP binding domain MAG.T1.5_01726 675635.Psed_5623 1.4e-07 62.4 Pseudonocardiales GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 2IR0P@201174,4E5DS@85010,COG0695@1,COG0695@2 NA|NA|NA O PFAM Glutaredoxin-like domain (DUF836) MAG.T1.5_01727 330214.NIDE0994 1.4e-131 475.7 Bacteria Bacteria COG1730@1,COG1730@2 NA|NA|NA O sister chromatid segregation MAG.T1.5_01728 330214.NIDE0994 4e-38 163.7 Bacteria Bacteria COG1730@1,COG1730@2 NA|NA|NA O sister chromatid segregation MAG.T1.5_01729 330214.NIDE0993 3.3e-137 494.6 Bacteria Bacteria COG0501@1,COG0501@2 NA|NA|NA O metalloendopeptidase activity MAG.T1.5_01730 330214.NIDE0992 2.9e-106 391.3 Bacteria rnhC GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 ko:K03471 ko03030,map03030 ko00000,ko00001,ko01000,ko03032 Bacteria COG1039@1,COG1039@2 NA|NA|NA L RNA-DNA hybrid ribonuclease activity MAG.T1.5_01731 330214.NIDE0991 2.6e-85 322.0 Nitrospirae CP_0228 3.5.4.16 ko:K07164,ko:K22391 ko00790,ko01100,map00790,map01100 M00126 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0UV@40117,COG1579@1,COG1579@2 NA|NA|NA S C4-type zinc ribbon domain MAG.T1.5_01733 330214.NIDE0990 4.2e-309 1066.6 Nitrospirae rpoD GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141 ko:K03086 ko00000,ko03021 Bacteria 3J0E4@40117,COG0568@1,COG0568@2 NA|NA|NA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released MAG.T1.5_01734 330214.NIDE0989 3.5e-295 1020.4 Nitrospirae dnaG GO:0003674,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090304,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 ko:K02316 ko03030,map03030 ko00000,ko00001,ko01000,ko03032 Bacteria 3J0IN@40117,COG0358@1,COG0358@2 NA|NA|NA L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication MAG.T1.5_01735 330214.NIDE0988 1.4e-48 198.7 Nitrospirae hinT GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019478,GO:0019752,GO:0043436,GO:0043530,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046144,GO:0046395,GO:0046416,GO:0046436,GO:0055130,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.1.1.226,2.1.1.227 ko:K02503,ko:K06442 ko00000,ko01000,ko03009,ko04147 Bacteria 3J0TA@40117,COG0537@1,COG0537@2 NA|NA|NA FG Scavenger mRNA decapping enzyme C-term binding MAG.T1.5_01736 330214.NIDE0987 1.2e-104 386.0 Nitrospirae hisE GO:0000105,GO:0000287,GO:0003674,GO:0003824,GO:0004636,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0043167,GO:0043169,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044419,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052803,GO:0071704,GO:0071944,GO:0075136,GO:0075139,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.4.19,3.6.1.31,5.3.1.16 ko:K01496,ko:K01523,ko:K01814,ko:K11755 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035,R04037,R04640 RC00002,RC00945,RC01055 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1606,iSB619.SA_RS14110,iYO844.BSU34860 Bacteria 3J0T7@40117,COG0139@1,COG0139@2,COG0140@1,COG0140@2 NA|NA|NA E Phosphoribosyl-AMP cyclohydrolase MAG.T1.5_01737 330214.NIDE0986 6e-127 460.3 Nitrospirae hisF GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 ko:K02500 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0GV@40117,COG0107@1,COG0107@2 NA|NA|NA E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit MAG.T1.5_01738 330214.NIDE0985 2.9e-112 411.4 Nitrospirae hisA GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0KA@40117,COG0106@1,COG0106@2 NA|NA|NA E Histidine biosynthesis protein MAG.T1.5_01739 667014.Thein_1211 7.8e-12 77.8 Thermodesulfobacteria Bacteria 2E6CS@1,2GH18@200940,3310E@2 NA|NA|NA MAG.T1.5_01740 330214.NIDE0983 2e-98 365.2 Nitrospirae hisH GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0K7@40117,COG0118@1,COG0118@2 NA|NA|NA E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR MAG.T1.5_01741 330214.NIDE0982 6.7e-102 376.7 Nitrospirae hisB GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0004424,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042578,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23,2.6.1.9,3.1.3.15,4.2.1.19 ko:K00013,ko:K00817,ko:K01089,ko:K01693 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R01158,R01163,R03012,R03013,R03243,R03457 RC00006,RC00017,RC00099,RC00242,RC00463,RC00888,RC00932 ko00000,ko00001,ko00002,ko01000,ko01007 iECO111_1330.ECO111_2746,iECS88_1305.ECS88_2121,iJN746.PP_0289,iLJ478.TM1039,iSB619.SA_RS14130,iUMNK88_1353.UMNK88_2570 Bacteria 3J0JI@40117,COG0131@1,COG0131@2 NA|NA|NA E Imidazoleglycerol-phosphate dehydratase MAG.T1.5_01742 330214.NIDE0981 2.6e-223 781.2 Nitrospirae hisD GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23,1.1.1.308 ko:K00013,ko:K15509 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 iYO844.BSU34910 Bacteria 3J0C6@40117,COG0141@1,COG0141@2 NA|NA|NA E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine MAG.T1.5_01743 330214.NIDE0980 4.2e-102 377.5 Nitrospirae hisG GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 ko:K00765,ko:K02502 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0T5@40117,COG0040@1,COG0040@2 NA|NA|NA F Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity MAG.T1.5_01744 330214.NIDE0979 3.3e-204 717.6 Nitrospirae murA GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008760,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016765,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 R00660 RC00350 ko00000,ko00001,ko01000,ko01011 Bacteria 3J0EE@40117,COG0766@1,COG0766@2 NA|NA|NA M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine MAG.T1.5_01745 330214.NIDE0978 1.4e-98 366.3 Nitrospirae prmC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464 2.1.1.297 ko:K02493 R10806 RC00003,RC03279 ko00000,ko01000,ko03012 Bacteria 3J0N5@40117,COG2890@1,COG2890@2 NA|NA|NA J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif MAG.T1.5_01746 330214.NIDE0977 2.1e-183 648.3 Nitrospirae prfA ko:K02835 ko00000,ko03012 Bacteria 3J0F6@40117,COG0216@1,COG0216@2 NA|NA|NA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA MAG.T1.5_01747 330214.NIDE0976 1.9e-32 144.4 Nitrospirae rpmE GO:0008150,GO:0040007 ko:K02909 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0S4@40117,COG0254@1,COG0254@2 NA|NA|NA J Binds the 23S rRNA MAG.T1.5_01748 330214.NIDE0975 5.7e-236 823.2 Nitrospirae rho GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576 ko:K02887,ko:K03628 ko03010,ko03018,map03010,map03018 M00178 br01610,ko00000,ko00001,ko00002,ko03011,ko03019,ko03021 Bacteria 3J0BK@40117,COG1158@1,COG1158@2 NA|NA|NA K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template MAG.T1.5_01749 330214.NIDE0974 3.5e-63 247.7 Bacteria Bacteria COG4911@1,COG4911@2 NA|NA|NA S Uncharacterized conserved protein (DUF2203) MAG.T1.5_01750 1384056.N787_00520 1e-13 82.8 Xanthomonadales yciI GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 ko:K05527,ko:K09780 ko00000,ko03000 Bacteria 1MZ9Z@1224,1S8UC@1236,1X7QC@135614,COG2350@1,COG2350@2 NA|NA|NA S BolA family transcriptional regulator MAG.T1.5_01751 330214.NIDE0972 1.8e-118 431.8 Nitrospirae ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 ko00000,ko00001,ko00002,ko02000 3.A.1.7 Bacteria 3J0YH@40117,COG0226@1,COG0226@2 NA|NA|NA P Evidence 2a Function of homologous gene experimentally demonstrated in an other organism MAG.T1.5_01752 330214.NIDE0971 5.4e-236 823.2 Nitrospirae porA 1.2.7.1 ko:K00169 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 3J0WN@40117,COG0674@1,COG0674@2 NA|NA|NA C Pyruvate:ferredoxin oxidoreductase core domain II MAG.T1.5_01753 330214.NIDE0970 1.5e-166 592.0 Nitrospirae porB 1.2.7.1 ko:K00170 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 3J0Z2@40117,COG1013@1,COG1013@2 NA|NA|NA C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain MAG.T1.5_01754 330214.NIDE0969 3.6e-123 447.6 Nitrospirae 1.2.7.1 ko:K00172 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 3J0Y6@40117,COG1014@1,COG1014@2 NA|NA|NA C Pyruvate ferredoxin/flavodoxin oxidoreductase MAG.T1.5_01755 330214.NIDE0968 1.3e-36 158.7 Nitrospirae porE 1.2.7.1 ko:K00171,ko:K00172,ko:K02573,ko:K13795,ko:K18930 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 3J1DG@40117,COG1144@1,COG1144@2 NA|NA|NA C Oxidoreductase MAG.T1.5_01759 1304883.KI912532_gene2937 8.7e-100 370.5 Proteobacteria Bacteria 1RAC8@1224,2DBHN@1,2Z9BF@2 NA|NA|NA MAG.T1.5_01761 1037409.BJ6T_25070 2.9e-42 179.9 Alphaproteobacteria Bacteria 1RCJY@1224,28PQC@1,2U8GR@28211,2ZCCE@2 NA|NA|NA MAG.T1.5_01763 330214.NIDE0966 3.6e-106 391.0 Bacteria fucA 2.2.1.8,4.1.2.17 ko:K01628,ko:K18847 ko00051,ko01120,map00051,map01120 R02262 RC00603,RC00604 ko00000,ko00001,ko01000 Bacteria COG0235@1,COG0235@2 NA|NA|NA G Class ii aldolase MAG.T1.5_01764 330214.NIDE0965 2e-140 505.4 Bacteria GO:0003674,GO:0003824,GO:0006629,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0044237,GO:0044238,GO:0044255,GO:0071704 ko:K07019 ko00000 Bacteria COG0429@1,COG0429@2 NA|NA|NA S poly(3-hydroxybutyrate) depolymerase activity MAG.T1.5_01765 330214.NIDE1586 6.8e-86 325.9 Bacteria 2.7.13.3 ko:K07708,ko:K07709 ko02020,map02020 M00497,M00499 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria COG2203@1,COG2203@2,COG4191@1,COG4191@2 NA|NA|NA T Gaf domain MAG.T1.5_01766 330214.NIDE0963 0.0 1345.1 Bacteria Bacteria COG0500@1,COG2226@2,COG2267@1,COG2267@2 NA|NA|NA Q methyltransferase MAG.T1.5_01769 330214.NIDE0960 3.2e-265 920.6 Nitrospirae dop GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.5.1.119,6.3.1.19 ko:K13571,ko:K20814 M00342 R11207 RC00090,RC00096 ko00000,ko00002,ko01000,ko03051 Bacteria 3J0XW@40117,COG4122@1,COG4122@2 NA|NA|NA S Pup-ligase protein MAG.T1.5_01770 330214.NIDE0959 4.3e-115 421.0 Nitrospirae prcA 3.4.25.1 ko:K03432 ko03050,map03050 M00342,M00343 ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 Bacteria 3J15S@40117,COG0638@1,COG0638@2 NA|NA|NA O Proteasome subunit MAG.T1.5_01771 330214.NIDE0958 3.3e-130 471.1 Nitrospirae prcB GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019774,GO:0019899,GO:0019941,GO:0030163,GO:0032991,GO:0035375,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 ko:K03433 ko03050,map03050 M00342,M00343 ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 Bacteria 3J11F@40117,COG0638@1,COG0638@2 NA|NA|NA O Proteasome subunit MAG.T1.5_01772 330214.NIDE0957 3.1e-24 117.1 Bacteria ubact Bacteria 2ERDX@1,33IZH@2 NA|NA|NA S May function as a protein modifier covalently attached to lysine residues of substrate proteins. This may serve to target the modified proteins for degradation by proteasomes MAG.T1.5_01773 330214.NIDE0956 6.5e-271 939.5 Nitrospirae dop GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.5.1.119,6.3.1.19 ko:K13571,ko:K20814 M00342 R11207 RC00090,RC00096 ko00000,ko00002,ko01000,ko03051 Bacteria 3J0ZW@40117,COG4122@1,COG4122@2 NA|NA|NA S Pup-ligase protein MAG.T1.5_01774 330214.NIDE0955 1.1e-298 1031.9 Nitrospirae ko:K13527 ko03050,map03050 M00342 ko00000,ko00001,ko00002,ko03051 Bacteria 3J0Z7@40117,COG1222@1,COG1222@2 NA|NA|NA O Proteasomal ATPase OB/ID domain MAG.T1.5_01775 330214.NIDE0954 1e-164 586.3 Nitrospirae degP 1.3.1.74 ko:K08070 ko00000,ko01000 Bacteria 3J0X9@40117,COG0265@1,COG0265@2 NA|NA|NA M Evidence 2a Function of homologous gene experimentally demonstrated in an other organism MAG.T1.5_01776 330214.NIDE0953 9.9e-60 236.1 Bacteria Bacteria COG0432@1,COG0432@2 NA|NA|NA S Uncharacterised protein family UPF0047 MAG.T1.5_01777 330214.NIDE0952 2.6e-131 474.9 Bacteria 3.6.1.11,3.6.1.40 ko:K01524,ko:K07012 ko00230,map00230 R03409 RC00002 ko00000,ko00001,ko01000,ko02048 Bacteria COG2206@1,COG2206@2 NA|NA|NA T PFAM metal-dependent phosphohydrolase, HD sub domain MAG.T1.5_01779 330214.NIDE0950 1.2e-60 239.2 Bacteria Bacteria COG0537@1,COG0537@2 NA|NA|NA FG bis(5'-adenosyl)-triphosphatase activity MAG.T1.5_01781 330214.NIDE0948 6.2e-124 451.1 Nitrospirae ko:K02450,ko:K07126 M00331 ko00000,ko00002,ko02044 9.B.42 Bacteria 3J1CG@40117,COG0457@1,COG0457@2,COG0790@1,COG0790@2 NA|NA|NA S Evidence 5 No homology to any previously reported sequences MAG.T1.5_01782 330214.NIDE0947 0.0 1220.3 Bacteria 3.1.3.3,4.6.1.1 ko:K01768,ko:K07315 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000,ko03021 Bacteria COG3829@1,COG3829@2,COG4252@1,COG4252@2 NA|NA|NA T Chase2 domain MAG.T1.5_01783 330214.NIDE0942 8.2e-103 380.2 Bacteria ko:K03640 ko00000,ko02000 2.C.1.2 Bacteria COG2885@1,COG2885@2 NA|NA|NA M chlorophyll binding MAG.T1.5_01784 330214.NIDE0941 1.1e-279 969.1 Bacteria ko:K07114 ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 Bacteria COG2304@1,COG2304@2 NA|NA|NA IU oxidoreductase activity MAG.T1.5_01785 330214.NIDE0940 1.1e-69 269.6 Bacteria srtA 3.4.22.70 ko:K07284 ko00000,ko01000,ko01002,ko01011 Bacteria COG3764@1,COG3764@2 NA|NA|NA M Sortase family MAG.T1.5_01786 330214.NIDE0939 2.3e-166 592.0 Bacteria Bacteria 2DKUD@1,30C6A@2 NA|NA|NA S Pfam:DUF2029 MAG.T1.5_01787 330214.NIDE0938 0.0 1484.9 Bacteria Bacteria COG3387@1,COG3387@2 NA|NA|NA G glucan 1,4-alpha-glucosidase activity MAG.T1.5_01788 330214.NIDE1804 0.0 1385.2 Nitrospirae czcA ko:K15726 ko00000,ko02000 2.A.6.1.2 Bacteria 3J0ZR@40117,COG3696@1,COG3696@2 NA|NA|NA P AcrB/AcrD/AcrF family MAG.T1.5_01790 330214.NIDE0186 4.2e-200 704.1 Bacteria Bacteria COG2124@1,COG2124@2 NA|NA|NA Q cytochrome p450 MAG.T1.5_01791 118168.MC7420_8133 1.1e-240 839.3 Oscillatoriales ko:K07190 ko04020,ko04910,ko04922,map04020,map04910,map04922 ko00000,ko00001 Bacteria 1G3VS@1117,1H860@1150,COG3387@1,COG3387@2 NA|NA|NA G Glycosyl hydrolases family 15 MAG.T1.5_01792 316055.RPE_2627 1.5e-11 75.1 Alphaproteobacteria Bacteria 1NH1S@1224,2UJ09@28211,COG2442@1,COG2442@2 NA|NA|NA S Protein of unknown function (DUF433) MAG.T1.5_01793 237368.SCABRO_00363 5e-141 507.7 Planctomycetes Bacteria 2J1MI@203682,COG3177@1,COG3177@2 NA|NA|NA S Fic/DOC family MAG.T1.5_01794 330214.NIDE2279 4.6e-41 175.6 Bacteria Bacteria COG0582@1,COG0582@2 NA|NA|NA L DNA integration MAG.T1.5_01797 566466.NOR53_835 2.7e-14 85.9 unclassified Gammaproteobacteria rpoS GO:0000988,GO:0000990,GO:0001000,GO:0001121,GO:0001123,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141 ko:K03087 ko02026,ko05111,map02026,map05111 ko00000,ko00001,ko03021 Bacteria 1J8SJ@118884,1MUDI@1224,1RN8V@1236,COG0568@1,COG0568@2 NA|NA|NA K Sigma-70 factor, region 1.2 MAG.T1.5_01800 1540091.A0A0A0RNF3_9CAUD 7.8e-27 127.5 Myoviridae Viruses 4QBHW@10239,4QJZQ@10662,4QTT7@28883 NA|NA|NA S sequence-specific DNA binding transcription factor activity MAG.T1.5_01808 398527.Bphyt_3727 1.7e-70 273.1 Burkholderiaceae Bacteria 1KBVI@119060,1RDUQ@1224,28IFP@1,2W4ND@28216,2Z8HD@2 NA|NA|NA S Protein of unknown function (DUF3644) MAG.T1.5_01809 1231057.AMGD01000054_gene75 1.2e-12 80.9 Bacilli Bacteria 1VZCM@1239,2FFXX@1,347UU@2,4HZ6X@91061 NA|NA|NA S RES domain MAG.T1.5_01810 536019.Mesop_4983 1.8e-37 162.5 Phyllobacteriaceae Bacteria 1PRVY@1224,2ADG6@1,2UWH5@28211,3136A@2,43QKD@69277 NA|NA|NA MAG.T1.5_01812 879310.HMPREF9162_0465 1.1e-07 62.8 Negativicutes Bacteria 1UKEF@1239,4H60C@909932,COG3620@1,COG3620@2 NA|NA|NA K Helix-turn-helix domain MAG.T1.5_01813 657322.FPR_09250 6.8e-14 83.6 Ruminococcaceae GO:0001666,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0036293,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0045926,GO:0045927,GO:0046483,GO:0048518,GO:0048519,GO:0050789,GO:0050896,GO:0065007,GO:0070482,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360 Bacteria 1VB8K@1239,24KV8@186801,3WM39@541000,COG4679@1,COG4679@2 NA|NA|NA S Phage derived protein Gp49-like (DUF891) MAG.T1.5_01816 330214.NIDE1873 0.0 1456.8 Bacteria Bacteria COG2982@1,COG2982@2 NA|NA|NA M Protein involved in outer membrane biogenesis MAG.T1.5_01817 330214.NIDE1874 2.3e-20 105.1 Bacteria Bacteria COG1357@1,COG1357@2 NA|NA|NA S protein homooligomerization MAG.T1.5_01818 330214.NIDE1875 1.3e-119 435.6 Nitrospirae lsfA 1.11.1.15 ko:K03386,ko:K03665 ko04214,map04214 ko00000,ko00001,ko01000,ko03009,ko04147 Bacteria 3J0T1@40117,COG0450@1,COG0450@2 NA|NA|NA O C-terminal domain of 1-Cys peroxiredoxin MAG.T1.5_01819 330214.NIDE1878 0.0 1201.8 Bacteria Bacteria COG1032@1,COG1032@2 NA|NA|NA C radical SAM domain protein MAG.T1.5_01820 330214.NIDE1879 4.5e-183 647.5 Bacteria Bacteria COG2206@1,COG2206@2 NA|NA|NA T PFAM metal-dependent phosphohydrolase, HD sub domain MAG.T1.5_01821 330214.NIDE1881 2.7e-139 501.9 Nitrospirae mtnW 4.1.1.39 ko:K01601 ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200 M00165,M00166,M00532 R00024,R03140 RC00172,RC00859 ko00000,ko00001,ko00002,ko01000 Bacteria 3J16S@40117,COG1850@1,COG1850@2 NA|NA|NA G Ribulose bisphosphate carboxylase large chain, catalytic domain MAG.T1.5_01822 330214.NIDE1882 1.3e-111 409.5 Bacteria kynB 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 Bacteria COG1878@1,COG1878@2 NA|NA|NA S arylformamidase activity MAG.T1.5_01823 330214.NIDE1884 5e-70 270.8 Bacteria dsbL ko:K03673 ko01503,map01503 M00728 ko00000,ko00001,ko00002,ko03110 Bacteria COG2761@1,COG2761@2 NA|NA|NA Q protein disulfide oxidoreductase activity MAG.T1.5_01824 330214.NIDE1885 2e-103 382.1 Bacteria ko:K16079 ko00000,ko02000 1.B.4.2.1 Bacteria COG3637@1,COG3637@2 NA|NA|NA M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety MAG.T1.5_01825 1162668.LFE_0841 2e-132 479.2 Nitrospirae clpX GO:0000166,GO:0000502,GO:0002020,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009376,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019899,GO:0019904,GO:0030163,GO:0030164,GO:0030312,GO:0030554,GO:0031333,GO:0031597,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0043335,GO:0044087,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0051704,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0097718,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 ko:K03544 ko04112,map04112 ko00000,ko00001,ko03110 Bacteria 3J0AM@40117,COG1219@1,COG1219@2 NA|NA|NA O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP MAG.T1.5_01832 330214.NIDE1889 2.9e-72 277.7 Nitrospirae msrB 1.8.4.12 ko:K07305 ko00000,ko01000 Bacteria 3J17K@40117,COG0229@1,COG0229@2 NA|NA|NA C SelR domain MAG.T1.5_01833 330214.NIDE1890 0.0 1443.7 Nitrospirae lon 3.4.21.53 ko:K01338 ko04112,map04112 ko00000,ko00001,ko01000,ko01002 Bacteria 3J0DQ@40117,COG0466@1,COG0466@2 NA|NA|NA O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner MAG.T1.5_01834 330214.NIDE1891 2.7e-232 811.6 Bacteria 2.7.11.1 ko:K08884 ko00000,ko01000,ko01001 Bacteria COG1413@1,COG1413@2 NA|NA|NA C deoxyhypusine monooxygenase activity MAG.T1.5_01835 330214.NIDE1892 2e-256 891.3 Nitrospirae otsA 2.4.1.15,2.4.1.245,2.4.1.347,2.5.1.135,3.1.3.12 ko:K00697,ko:K13057,ko:K16055,ko:K20436 ko00500,ko00525,ko01100,ko01130,map00500,map00525,map01100,map01130 M00815 R02737,R02778,R08946,R10525,R11239,R11250,R11306,R11497 RC00005,RC00017,RC00049,RC02748,RC03400,RC03401 ko00000,ko00001,ko00002,ko01000,ko01003 GT20,GT4 Bacteria 3J10Z@40117,COG0380@1,COG0380@2 NA|NA|NA G Glycosyltransferase family 20 MAG.T1.5_01836 330214.NIDE1893 8e-173 613.2 Bacteria rlmL GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016423,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.173,2.1.1.264 ko:K07444,ko:K12297 R07234 RC00003 ko00000,ko01000,ko03009 Bacteria COG0116@1,COG0116@2 NA|NA|NA L 23S rRNA (guanine(2445)-N(2))-methyltransferase activity MAG.T1.5_01837 330214.NIDE1894 3.3e-92 344.4 Bacteria 3.6.1.13 ko:K01515 ko00230,map00230 R01054 RC00002 ko00000,ko00001,ko01000 Bacteria COG1051@1,COG1051@2 NA|NA|NA F GDP-mannose mannosyl hydrolase activity MAG.T1.5_01838 330214.NIDE1895 1.3e-32 145.6 Bacteria hesB ko:K07390,ko:K13628,ko:K15724 ko00000,ko03016,ko03029,ko03110 Bacteria COG0316@1,COG0316@2 NA|NA|NA S protein maturation MAG.T1.5_01839 330214.NIDE1896 4e-38 163.7 Bacteria ko:K06218 ko00000,ko02048 Bacteria COG2026@1,COG2026@2 NA|NA|NA DJ nuclease activity MAG.T1.5_01841 330214.NIDE1902 7.3e-84 316.6 Bacteria ko:K03088 ko00000,ko03021 Bacteria COG1595@1,COG1595@2 NA|NA|NA K DNA-templated transcription, initiation MAG.T1.5_01843 330214.NIDE1906 1.2e-198 699.1 Nitrospirae yhaO ko:K03547 ko00000,ko03400 Bacteria 3J0UK@40117,COG0420@1,COG0420@2 NA|NA|NA L Calcineurin-like phosphoesterase superfamily domain MAG.T1.5_01844 330214.NIDE1907 0.0 1223.8 Nitrospirae Bacteria 3J110@40117,COG1196@1,COG1196@2,COG4717@1,COG4717@2 NA|NA|NA D AAA domain MAG.T1.5_01845 330214.NIDE1909 2e-105 388.7 Bacteria 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria COG4221@1,COG4221@2 NA|NA|NA IQ oxidoreductase activity MAG.T1.5_01846 330214.NIDE1910 2.7e-98 364.8 Bacteria ko:K07034 ko00000 Bacteria COG1584@1,COG1584@2 NA|NA|NA S GPR1 FUN34 yaaH family protein MAG.T1.5_01848 330214.NIDE1914 1.2e-91 342.4 Nitrospirae mutY GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:1901360 2.1.1.37,2.1.3.15,6.4.1.2 ko:K00558,ko:K01962,ko:K01963,ko:K03575 ko00061,ko00270,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko03410,ko05206,map00061,map00270,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212,map03410,map05206 M00035,M00082,M00376 R00742,R04386,R04858 RC00003,RC00040,RC00253,RC00332,RC00367 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036,ko03400 Bacteria 3J160@40117,COG1194@1,COG1194@2 NA|NA|NA L FES MAG.T1.5_01849 330214.NIDE1915 2.4e-55 221.5 Bacteria mutY 3.6.1.55 ko:K03574,ko:K03575 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria COG0494@1,COG0494@2 NA|NA|NA L nUDIX hydrolase MAG.T1.5_01850 330214.NIDE1916 5.5e-127 460.3 Bacteria polB 2.7.7.7 ko:K02336,ko:K06877,ko:K07501 ko00000,ko01000,ko03400 Bacteria COG0417@1,COG0417@2 NA|NA|NA L DNA replication proofreading MAG.T1.5_01853 330214.NIDE1919 5.7e-242 843.2 Nitrospirae miaB GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035597,GO:0035600,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360 2.8.4.3 ko:K06168 R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 Bacteria 3J0GE@40117,COG0621@1,COG0621@2 NA|NA|NA J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine MAG.T1.5_01854 330214.NIDE1920 8.1e-198 696.4 Nitrospirae yqeV GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035598,GO:0035600,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050497,GO:0071704,GO:0090304,GO:1901360 2.8.4.5 ko:K18707 R10649 RC00003,RC03221 ko00000,ko01000,ko03016 Bacteria 3J112@40117,COG0621@1,COG0621@2 NA|NA|NA J Uncharacterized protein family UPF0004 MAG.T1.5_01856 330214.NIDE1922 7e-129 466.8 Bacteria Bacteria COG0589@1,COG0589@2 NA|NA|NA T AMP binding MAG.T1.5_01857 330214.NIDE1923 2.3e-87 328.6 Bacteria GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 ko:K07100 ko00000 Bacteria COG1073@1,COG1073@2 NA|NA|NA S thiolester hydrolase activity MAG.T1.5_01859 330214.NIDE1925 1.8e-76 292.0 Nitrospirae Bacteria 3J1E9@40117,COG0589@1,COG0589@2 NA|NA|NA T Universal stress protein family MAG.T1.5_01860 330214.NIDE1926 9.1e-53 213.0 Bacteria amcY GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.7.2.1 ko:K00368 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 Bacteria COG3794@1,COG3794@2 NA|NA|NA C PFAM blue (type 1) copper domain protein MAG.T1.5_01861 330214.NIDE1927 2.2e-136 491.9 Nitrospirae mntH ko:K03322 ko00000,ko02000 2.A.55.2.6,2.A.55.3 Bacteria 3J1A7@40117,COG0589@1,COG0589@2 NA|NA|NA T Belongs to the universal stress protein A family MAG.T1.5_01863 234267.Acid_5736 1.8e-06 60.8 Bacteria Bacteria COG3012@1,COG3012@2 NA|NA|NA MAG.T1.5_01864 330214.NIDE1930 6.6e-62 243.4 Nitrospirae fdsG 1.6.5.3 ko:K00124,ko:K00127,ko:K00334,ko:K00335 ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200 M00144 R00519,R11945 RC00061,RC02796 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 3J1BD@40117,COG1905@1,COG1905@2 NA|NA|NA C Thioredoxin-like [2Fe-2S] ferredoxin MAG.T1.5_01865 330214.NIDE1931 1.1e-257 895.6 Nitrospirae fdsB 1.6.5.3 ko:K00124,ko:K00335 ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200 M00144 R00519,R11945 RC00061,RC02796 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 3J0WX@40117,COG1894@1,COG1894@2 NA|NA|NA C NADH-ubiquinone oxidoreductase-F iron-sulfur binding region MAG.T1.5_01866 330214.NIDE1932 0.0 1548.5 Nitrospirae fdsA 1.17.1.10,1.17.1.9 ko:K00123,ko:K05299 ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200 M00377 R00134,R00519 RC02796 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0UR@40117,COG3383@1,COG3383@2 NA|NA|NA C Molydopterin dinucleotide binding domain MAG.T1.5_01867 330214.NIDE1933 9e-121 439.9 Bacteria focA ko:K02598,ko:K06212,ko:K21993 ko00000,ko02000 1.A.16.1.1,1.A.16.1.3,1.A.16.2,1.A.16.3 Bacteria COG2116@1,COG2116@2 NA|NA|NA P formate transmembrane transporter activity MAG.T1.5_01869 330214.NIDE1934 2.1e-206 724.9 Nitrospirae ampG GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015672,GO:0015835,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1901264,GO:1902600 ko:K08218 ko01501,map01501 M00628 ko00000,ko00001,ko00002,ko02000 2.A.1.25 Bacteria 3J0ZP@40117,COG0477@1,COG2814@2 NA|NA|NA EGP Acetyl-coenzyme A transporter 1 MAG.T1.5_01870 1166018.FAES_0893 2.7e-55 223.4 Cytophagia Bacteria 28IG1@1,2Z8HJ@2,47NG6@768503,4NK1S@976 NA|NA|NA MAG.T1.5_01873 330214.NIDE1937 0.0 2252.6 Nitrospirae nrdJ 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 Bacteria 3J0MG@40117,COG0209@1,COG0209@2 NA|NA|NA F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen MAG.T1.5_01878 330214.NIDE1646 4.5e-16 91.7 Bacteria Bacteria 2EUFJ@1,33MXU@2 NA|NA|NA MAG.T1.5_01879 543913.D521_1470 5.6e-09 67.8 Betaproteobacteria Bacteria 1RH59@1224,2E8C5@1,2W4XB@28216,332QT@2 NA|NA|NA MAG.T1.5_01880 1121033.AUCF01000028_gene377 2.1e-21 110.2 Rhodospirillales degP GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 Bacteria 1MU63@1224,2JQVG@204441,2TQPZ@28211,COG0265@1,COG0265@2 NA|NA|NA O Belongs to the peptidase S1C family MAG.T1.5_01882 330214.NIDE0947 2.7e-143 516.5 Bacteria 3.1.3.3,4.6.1.1 ko:K01768,ko:K07315 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000,ko03021 Bacteria COG3829@1,COG3829@2,COG4252@1,COG4252@2 NA|NA|NA T Chase2 domain MAG.T1.5_01889 330214.NIDE2031 8.4e-207 726.1 Bacteria fbp 3.1.3.11,4.1.2.13 ko:K01622 ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00003 R00762,R01068,R01070,R02568,R04780 RC00017,RC00438,RC00439 ko00000,ko00001,ko00002,ko01000 Bacteria COG1980@1,COG1980@2 NA|NA|NA G fructose-bisphosphate aldolase activity MAG.T1.5_01890 330214.NIDE2032 1.5e-38 165.2 Bacteria Bacteria COG0662@1,COG0662@2 NA|NA|NA G Cupin 2, conserved barrel domain protein MAG.T1.5_01891 330214.NIDE2033 1.5e-65 255.4 Nitrospirae 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 3J1DW@40117,COG4747@1,COG4747@2 NA|NA|NA S ACT domain MAG.T1.5_01892 330214.NIDE2034 2.7e-107 394.8 Nitrospirae rlpA GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 ko:K03642 ko00000 Bacteria 3J0PD@40117,COG0797@1,COG0797@2 NA|NA|NA M Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides MAG.T1.5_01893 330214.NIDE2035 8.8e-232 809.3 Nitrospirae gldE Bacteria 3J0KN@40117,COG1253@1,COG1253@2 NA|NA|NA S Transporter associated domain MAG.T1.5_01894 330214.NIDE2036 0.0 1143.6 Nitrospirae ligA GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 Bacteria 3J0W8@40117,COG0272@1,COG0272@2 NA|NA|NA L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA MAG.T1.5_01895 330214.NIDE2037 0.0 1119.4 Bacteria Bacteria COG1916@1,COG1916@2 NA|NA|NA MAG.T1.5_01896 330214.NIDE2038 6.3e-171 606.7 Bacteria ko:K04748 R00294 RC02794 ko00000 3.D.4.10 Bacteria COG0714@1,COG0714@2 NA|NA|NA KLT Associated with various cellular activities MAG.T1.5_01897 330214.NIDE2039 2.1e-75 288.9 Bacteria Bacteria COG1388@1,COG1388@2 NA|NA|NA M LysM domain MAG.T1.5_01898 330214.NIDE2040 1.4e-265 921.8 Nitrospirae trpE 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0FG@40117,COG0147@1,COG0147@2 NA|NA|NA EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia MAG.T1.5_01899 330214.NIDE2041 1.7e-99 368.6 Nitrospirae trpG GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 2.4.2.18,2.6.1.85,4.1.3.27 ko:K01658,ko:K01664,ko:K13497 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01073,R01716 RC00010,RC00440,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2496 Bacteria 3J0H8@40117,COG0512@1,COG0512@2 NA|NA|NA EH Peptidase C26 MAG.T1.5_01900 330214.NIDE2042 1.8e-168 598.6 Nitrospirae trpD GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 ko:K00766,ko:K13497 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R00985,R00986,R01073 RC00010,RC00440,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2495 Bacteria 3J0HE@40117,COG0547@1,COG0547@2 NA|NA|NA E Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) MAG.T1.5_01901 330214.NIDE2043 4.1e-134 484.2 Nitrospirae trpC GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831 4.1.1.48,5.3.1.24 ko:K01609,ko:K13498 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508,R03509 RC00944,RC00945 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2494,iJN746.PP_0422 Bacteria 3J0NT@40117,COG0134@1,COG0134@2 NA|NA|NA E Indole-3-glycerol phosphate synthase MAG.T1.5_01903 330214.NIDE2045 9.7e-99 366.3 Nitrospirae trpF GO:0000162,GO:0003674,GO:0003824,GO:0004425,GO:0004640,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.48,4.2.1.160,4.2.1.20,5.3.1.24 ko:K01696,ko:K01817,ko:K13498,ko:K22100 ko00260,ko00400,ko00790,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map00790,map01100,map01110,map01130,map01230 M00023,M00840 R00674,R02340,R02722,R03508,R03509,R11072 RC00209,RC00210,RC00700,RC00701,RC00944,RC00945,RC02868,RC03343 ko00000,ko00001,ko00002,ko01000 iJN678.trpF,iPC815.YPO2205,iSBO_1134.SBO_1804,iSDY_1059.SDY_1330 Bacteria 3J0SA@40117,COG0135@1,COG0135@2 NA|NA|NA E N-(5'phosphoribosyl)anthranilate (PRA) isomerase MAG.T1.5_01904 330214.NIDE2046 7.5e-214 749.6 Nitrospirae trpB 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0E1@40117,COG0133@1,COG0133@2 NA|NA|NA E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine MAG.T1.5_01905 330214.NIDE2047 6.5e-129 466.8 Nitrospirae trpA 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0ME@40117,COG0159@1,COG0159@2 NA|NA|NA E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate MAG.T1.5_01906 330214.NIDE2048 3.2e-139 501.5 Bacteria Bacteria COG2203@1,COG2203@2 NA|NA|NA T Gaf domain MAG.T1.5_01907 330214.NIDE2049 3.6e-95 354.4 Bacteria Bacteria 2FJ9R@1,34AZR@2 NA|NA|NA MAG.T1.5_01908 330214.NIDE2050 9.8e-195 686.0 Bacteria Bacteria COG2067@1,COG2067@2 NA|NA|NA I long-chain fatty acid transporting porin activity MAG.T1.5_01909 330214.NIDE2051 2.5e-113 414.8 Nitrospirae lolD ko:K09810 ko02010,map02010 M00255 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.125 Bacteria 3J0IT@40117,COG1136@1,COG1136@2 NA|NA|NA V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner MAG.T1.5_01910 330214.NIDE2052 7e-218 763.1 Nitrospirae lolC GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008104,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0034613,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0070727,GO:0071944,GO:0072657,GO:0089705,GO:0098796,GO:0098797,GO:1990778 ko:K02004,ko:K09808 ko02010,map02010 M00255,M00258 ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.125 Bacteria 3J0EF@40117,COG4591@1,COG4591@2 NA|NA|NA M MacB-like periplasmic core domain MAG.T1.5_01911 330214.NIDE2053 2.3e-268 931.0 Nitrospirae lysS GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006518,GO:0006520,GO:0006629,GO:0006644,GO:0006650,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009059,GO:0009405,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019637,GO:0019752,GO:0030312,GO:0030322,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0040007,GO:0042221,GO:0042391,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046471,GO:0046483,GO:0046486,GO:0046677,GO:0046872,GO:0050896,GO:0051704,GO:0065007,GO:0065008,GO:0071704,GO:0071944,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iAF1260.b4129,iECDH1ME8569_1439.ECDH1ME8569_3989,iECW_1372.ECW_m4490,iEcDH1_1363.EcDH1_3862,iJN678.lysS,iJO1366.b4129,iWFL_1372.ECW_m4490 Bacteria 3J0AW@40117,COG1190@1,COG1190@2 NA|NA|NA J tRNA synthetases class II (D, K and N) MAG.T1.5_01912 330214.NIDE2054 5.3e-201 706.8 Nitrospirae prfB GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02836 ko00000,ko03012 Bacteria 3J0EX@40117,COG1186@1,COG1186@2 NA|NA|NA J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA MAG.T1.5_01913 330214.NIDE2055 3.7e-280 970.3 Nitrospirae lnt ko:K03820 ko00000,ko01000 GT2 Bacteria 3J0HA@40117,COG0815@1,COG0815@2 NA|NA|NA M Carbon-nitrogen hydrolase MAG.T1.5_01919 330214.NIDE2061 6.1e-72 276.9 Bacteria ko:K07226 ko00000 Bacteria COG0748@1,COG0748@2 NA|NA|NA P coenzyme F420 binding MAG.T1.5_01920 330214.NIDE2063 3.1e-63 247.7 Bacteria osmE GO:0006950,GO:0006970,GO:0008150,GO:0009628,GO:0050896 ko:K04064,ko:K06186 ko00000,ko02000 1.B.33.1 Bacteria COG2913@1,COG2913@2 NA|NA|NA J Gram-negative-bacterium-type cell outer membrane assembly MAG.T1.5_01921 330214.NIDE2064 6e-82 310.5 Bacteria Bacteria 2ATAH@1,31ITJ@2 NA|NA|NA MAG.T1.5_01922 330214.NIDE2065 2e-63 248.4 Bacteria Bacteria 2B047@1,31SEM@2 NA|NA|NA MAG.T1.5_01923 330214.NIDE2066 5.9e-82 310.5 Bacteria Bacteria 2B047@1,31SEM@2 NA|NA|NA MAG.T1.5_01924 330214.NIDE2067 7.1e-111 406.8 Bacteria Bacteria COG3751@1,COG3751@2 NA|NA|NA O 2OG-Fe(II) oxygenase superfamily MAG.T1.5_01925 330214.NIDE2069 5.4e-23 112.8 Bacteria Bacteria 33KP1@2,arCOG12353@1 NA|NA|NA MAG.T1.5_01926 330214.NIDE2070 1.9e-202 712.2 Bacteria 3.1.3.3,4.6.1.1 ko:K01768,ko:K07315 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000,ko03021 Bacteria COG0745@1,COG0745@2,COG2202@1,COG2202@2 NA|NA|NA T Pas domain MAG.T1.5_01928 330214.NIDE2073 0.0 1099.0 Bacteria top6B 5.99.1.3 ko:K03167 ko00000,ko01000,ko03032 Bacteria COG1389@1,COG1389@2 NA|NA|NA L DNA topoisomerase II activity MAG.T1.5_01929 330214.NIDE2074 2.7e-205 721.1 Bacteria top6A 5.99.1.3 ko:K03166 ko00000,ko01000,ko03032 Bacteria COG1697@1,COG1697@2 NA|NA|NA L DNA topoisomerase VI subunit A MAG.T1.5_01934 330214.NIDE2082 3.7e-101 374.4 Bacteria Bacteria COG0791@1,COG0791@2 NA|NA|NA M cysteine-type peptidase activity MAG.T1.5_01935 330214.NIDE2083 6.4e-272 943.0 Nitrospirae pgm GO:0000271,GO:0003674,GO:0003824,GO:0004614,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0005996,GO:0006006,GO:0006012,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0016868,GO:0019318,GO:0019320,GO:0019388,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0055114,GO:0071704,GO:1901575,GO:1901576 5.4.2.2 ko:K01835 ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00549 R00959,R01057,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 iAPECO1_1312.APECO1_1376,iECED1_1282.ECED1_0670,iECNA114_1301.ECNA114_0627,iECOK1_1307.ECOK1_0699,iECP_1309.ECP_0709,iECS88_1305.ECS88_0725,iJN678.pgm,iLF82_1304.LF82_1632,iNRG857_1313.NRG857_03110,iUMN146_1321.UM146_14115,iYL1228.KPN_00711 Bacteria 3J1FS@40117,COG0033@1,COG0033@2 NA|NA|NA G Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III MAG.T1.5_01936 330214.NIDE2084 1.4e-43 181.8 Nitrospirae Bacteria 3J1BP@40117,COG0526@1,COG0526@2 NA|NA|NA CO Thioredoxin domain MAG.T1.5_01937 330214.NIDE2085 0.0 1434.9 Bacteria addB 3.6.4.12 ko:K16899 ko00000,ko01000,ko03400 Bacteria COG3857@1,COG3857@2 NA|NA|NA L exonuclease activity MAG.T1.5_01938 330214.NIDE2086 0.0 1584.7 Nitrospirae 3.1.11.5,3.1.12.1,3.6.4.12 ko:K01144,ko:K07464,ko:K16898 ko00000,ko01000,ko02048,ko03400 Bacteria 3J16M@40117,COG1074@1,COG1074@2 NA|NA|NA L PD-(D/E)XK nuclease superfamily MAG.T1.5_01939 330214.NIDE2087 2.7e-54 218.0 Bacteria Bacteria COG3063@1,COG3063@2 NA|NA|NA NU photosynthesis MAG.T1.5_01940 330214.NIDE2088 4.2e-147 527.3 Nitrospirae lgt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008961,GO:0009058,GO:0009059,GO:0009249,GO:0009898,GO:0009987,GO:0010467,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0040007,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051604,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0140096,GO:1901564,GO:1901566,GO:1901576 2.1.1.199 ko:K03438,ko:K13292 ko00000,ko01000,ko03009 Bacteria 3J0G4@40117,COG0682@1,COG0682@2 NA|NA|NA M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins MAG.T1.5_01941 330214.NIDE2089 3.1e-29 134.0 Bacteria XK27_07760 Bacteria COG4980@1,COG4980@2 NA|NA|NA D gas vesicle protein MAG.T1.5_01946 330214.NIDE2253 2.5e-49 201.4 Bacteria ygdD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria COG2363@1,COG2363@2 NA|NA|NA S Protein of unknown function (DUF423) MAG.T1.5_01948 330214.NIDE2255 3.1e-131 474.6 Nitrospirae yndB 3.1.1.101,3.1.1.102,3.1.1.45,3.1.1.76 ko:K01061,ko:K06889,ko:K07100,ko:K11750,ko:K21104,ko:K21105,ko:K22249 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222,R11540,R11541 RC00020,RC00041,RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 Bacteria 3J1B9@40117,COG0412@1,COG0412@2 NA|NA|NA Q Alpha/beta hydrolase family MAG.T1.5_01949 330214.NIDE2257 7.3e-138 496.9 Bacteria Bacteria COG0673@1,COG0673@2 NA|NA|NA S inositol 2-dehydrogenase activity MAG.T1.5_01950 330214.NIDE2258 2.2e-32 144.4 Bacteria Bacteria COG1522@1,COG1522@2 NA|NA|NA K sequence-specific DNA binding MAG.T1.5_01952 330214.NIDE2260 4.9e-250 870.2 Nitrospirae comM ko:K07391 ko00000 Bacteria 3J0ZK@40117,COG0606@1,COG0606@2 NA|NA|NA O Magnesium chelatase, subunit ChlI C-terminal MAG.T1.5_01955 330214.NIDE2263 0.0 1564.7 Nitrospirae clpB GO:0003674,GO:0005488,GO:0005515,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0042802,GO:0043170,GO:0044238,GO:0071704,GO:1901564 ko:K03694,ko:K03695 ko04213,map04213 ko00000,ko00001,ko03110 Bacteria 3J0AV@40117,COG0542@1,COG0542@2 NA|NA|NA O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE MAG.T1.5_01957 1408422.JHYF01000009_gene1958 3.8e-15 89.0 Clostridiaceae Bacteria 1V1MY@1239,24H5K@186801,28PHB@1,2ZC7V@2,36IHD@31979 NA|NA|NA MAG.T1.5_01958 330214.NIDE2265 9.2e-222 776.2 Nitrospirae 2.7.13.3 ko:K07651,ko:K07711 ko02020,ko02024,map02020,map02024 M00458,M00502 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 3J10G@40117,COG2770@1,COG2770@2,COG5002@1,COG5002@2 NA|NA|NA T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain MAG.T1.5_01959 330214.NIDE2266 1.7e-84 319.3 Bacteria yttA 2.7.13.3 ko:K07184,ko:K07777,ko:K12065,ko:K13527 ko02020,ko03050,map02020,map03050 M00342,M00478 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02044,ko03051 3.A.7.11.1 Bacteria COG2433@1,COG2433@2 NA|NA|NA MAG.T1.5_01960 330214.NIDE2267 9.8e-237 825.9 Nitrospirae yfhA GO:0000156,GO:0000160,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001130,GO:0001150,GO:0001151,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0023052,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035326,GO:0035556,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060089,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 ko:K07715 ko02020,ko02024,map02020,map02024 M00502 ko00000,ko00001,ko00002,ko02022 Bacteria 3J0ZU@40117,COG2204@1,COG2204@2 NA|NA|NA T Bacterial regulatory protein, Fis family MAG.T1.5_01964 330214.NIDE2271 3.5e-115 421.0 Bacteria Bacteria 2E1AM@1,32QU2@2 NA|NA|NA MAG.T1.5_01966 330214.NIDE2273 5.1e-60 236.9 Nitrospirae Bacteria 294Y5@1,2ZSB2@2,3J1DZ@40117 NA|NA|NA MAG.T1.5_01970 330214.NIDE2280 9.4e-256 889.0 Bacteria fleQ ko:K10941 ko02020,ko02025,ko05111,map02020,map02025,map05111 ko00000,ko00001,ko03000 Bacteria COG2204@1,COG2204@2 NA|NA|NA T phosphorelay signal transduction system MAG.T1.5_01971 1121438.JNJA01000002_gene3791 2.7e-11 77.4 Desulfovibrionales slt ko:K07114,ko:K08309 ko00000,ko01000,ko01011,ko02000 1.A.13.2.2,1.A.13.2.3 GH23 Bacteria 1R5H0@1224,2M7TT@213115,2WM7U@28221,42PMR@68525,COG0457@1,COG0457@2,COG1729@1,COG1729@2 NA|NA|NA K repeat-containing protein MAG.T1.5_01972 330214.NIDE2283 1.6e-177 629.0 Bacteria gnfL 2.7.13.3 ko:K07708,ko:K07710,ko:K10942 ko02020,ko05111,map02020,map05111 M00497,M00500,M00515 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria COG3852@1,COG3852@2 NA|NA|NA T phosphorelay sensor kinase activity MAG.T1.5_01973 330214.NIDE2284 8e-239 832.8 Nitrospirae atoC ko:K07713,ko:K07714,ko:K10943 ko02020,ko05111,map02020,map05111 M00499,M00500,M00515 ko00000,ko00001,ko00002,ko02022 Bacteria 3J0FP@40117,COG2204@1,COG2204@2 NA|NA|NA T Bacterial regulatory protein, Fis family MAG.T1.5_01974 330214.NIDE2285 3.3e-60 237.7 Nitrospirae flgB ko:K02387 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 3J0R3@40117,COG1815@1,COG1815@2 NA|NA|NA N Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body MAG.T1.5_01975 330214.NIDE2286 1.6e-71 275.4 Nitrospirae flgC GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009425,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588 ko:K02388 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 3J0TK@40117,COG1558@1,COG1558@2 NA|NA|NA N Belongs to the flagella basal body rod proteins family MAG.T1.5_01976 330214.NIDE2287 1.7e-37 161.8 Nitrospirae fliE ko:K02408 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 3J0UT@40117,COG1677@1,COG1677@2 NA|NA|NA N Flagellar hook-basal body complex protein FliE MAG.T1.5_01977 330214.NIDE2288 5.5e-241 840.1 Nitrospirae fliF ko:K02409 ko02040,map02040 ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 Bacteria 3J0A6@40117,COG1766@1,COG1766@2 NA|NA|NA N The M ring may be actively involved in energy transduction MAG.T1.5_01978 330214.NIDE2289 1.4e-165 589.0 Nitrospirae fliG GO:0001539,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006928,GO:0006935,GO:0008150,GO:0009288,GO:0009605,GO:0009987,GO:0040011,GO:0042221,GO:0042330,GO:0042802,GO:0042803,GO:0042995,GO:0043226,GO:0043228,GO:0044403,GO:0044419,GO:0044464,GO:0046982,GO:0046983,GO:0048870,GO:0050896,GO:0051179,GO:0051674,GO:0051701,GO:0051704,GO:0052116,GO:0052126,GO:0052127,GO:0052143,GO:0052192,GO:0052195,GO:0052216,GO:0052243,GO:0071973,GO:0071978,GO:0097588 ko:K02410 ko02030,ko02040,map02030,map02040 ko00000,ko00001,ko02035 Bacteria 3J0GZ@40117,COG1536@1,COG1536@2 NA|NA|NA N FliG middle domain MAG.T1.5_01979 330214.NIDE2290 2.8e-148 531.6 Bacteria hrpE ko:K02411,ko:K03223,ko:K03413 ko02020,ko02030,ko02040,ko03070,map02020,map02030,map02040,map03070 M00332,M00506,M00660 ko00000,ko00001,ko00002,ko02022,ko02035,ko02044 3.A.6.1,3.A.6.2,3.A.6.3 Bacteria COG1317@1,COG1317@2,COG2204@1,COG2204@2 NA|NA|NA N bacterial-type flagellum organization MAG.T1.5_01980 330214.NIDE2291 1.1e-231 808.9 Nitrospirae fliI GO:0003674,GO:0005488,GO:0005515,GO:0042802 3.6.3.14 ko:K02412 ko02040,map02040 ko00000,ko00001,ko01000,ko02035,ko02044 3.A.6.2,3.A.6.3 Bacteria 3J0BV@40117,COG1157@1,COG1157@2 NA|NA|NA N ATP synthase alpha/beta family, beta-barrel domain MAG.T1.5_01982 330214.NIDE2293 1.4e-55 223.0 Bacteria ylxF ko:K02383 ko00000,ko02035 Bacteria COG3334@1,COG3334@2 NA|NA|NA S PFAM MgtE intracellular MAG.T1.5_01984 330214.NIDE2296 6.8e-36 156.4 Nitrospirae flgD GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588 ko:K02389 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 3J0U1@40117,COG1843@1,COG1843@2 NA|NA|NA N flagellar hook MAG.T1.5_01985 330214.NIDE2297 2.7e-166 591.7 Nitrospirae ko:K02390 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 3J0IF@40117,COG1749@1,COG1749@2 NA|NA|NA N Flagellar basal body protein FlaE MAG.T1.5_01986 330214.NIDE2298 3.1e-74 284.6 Nitrospirae fliL ko:K02415 ko00000,ko02035 Bacteria 3J0QH@40117,COG1580@1,COG1580@2 NA|NA|NA N Controls the rotational direction of flagella during chemotaxis MAG.T1.5_01987 330214.NIDE2299 8.1e-174 616.3 Nitrospirae fliM ko:K02416 ko02030,ko02040,map02030,map02040 ko00000,ko00001,ko02035 Bacteria 3J0CU@40117,COG1868@1,COG1868@2 NA|NA|NA N Flagellar motor switch protein FliM MAG.T1.5_01988 330214.NIDE2300 1e-49 202.6 Nitrospirae fliN GO:0005575,GO:0005623,GO:0005886,GO:0009288,GO:0009425,GO:0016020,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0071944 ko:K02417 ko02030,ko02040,map02030,map02040 ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 Bacteria 3J0QM@40117,COG1886@1,COG1886@2 NA|NA|NA N Type III flagellar switch regulator (C-ring) FliN C-term MAG.T1.5_01989 330214.NIDE2301 2.3e-33 148.3 Bacteria fliP ko:K02418,ko:K02419 ko02040,map02040 ko00000,ko00001,ko02035,ko02044 3.A.6.2 Bacteria COG3190@1,COG3190@2 NA|NA|NA N flagellar MAG.T1.5_01990 330214.NIDE2302 4.8e-108 397.5 Nitrospirae fliP GO:0006935,GO:0008150,GO:0009605,GO:0040011,GO:0042221,GO:0042330,GO:0044403,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0052116,GO:0052126,GO:0052127,GO:0052143,GO:0052192,GO:0052195,GO:0052216,GO:0052243 ko:K02419,ko:K03226 ko02040,ko03070,map02040,map03070 M00332,M00542,M00660 ko00000,ko00001,ko00002,ko02035,ko02044 3.A.6.1,3.A.6.2,3.A.6.3 Bacteria 3J0HW@40117,COG1338@1,COG1338@2 NA|NA|NA N Plays a role in the flagellum-specific transport system MAG.T1.5_01991 330214.NIDE2303 2.4e-35 154.5 Nitrospirae fliQ ko:K02420,ko:K03227 ko02040,ko03070,map02040,map03070 M00332,M00542,M00660 ko00000,ko00001,ko00002,ko02035,ko02044 3.A.6.1,3.A.6.2,3.A.6.3 Bacteria 3J0VH@40117,COG1987@1,COG1987@2 NA|NA|NA N Role in flagellar biosynthesis MAG.T1.5_01992 330214.NIDE2304 6e-119 433.7 Nitrospirae fliR ko:K02421,ko:K03228,ko:K13820 ko02040,ko03070,map02040,map03070 M00332,M00542,M00660 ko00000,ko00001,ko00002,ko02035,ko02044 3.A.6.1,3.A.6.2,3.A.6.3 Bacteria 3J0QA@40117,COG1684@1,COG1684@2 NA|NA|NA N Bacterial export proteins, family 1 MAG.T1.5_01993 330214.NIDE2305 3.8e-164 584.3 Nitrospirae flhB GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02401,ko:K02556,ko:K03229,ko:K04061,ko:K13820 ko02020,ko02030,ko02040,ko03070,map02020,map02030,map02040,map03070 M00332,M00542,M00660 ko00000,ko00001,ko00002,ko02000,ko02035,ko02044 1.A.30.1,3.A.6.1,3.A.6.2,3.A.6.3 Bacteria 3J0J3@40117,COG1377@1,COG1377@2 NA|NA|NA N Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin MAG.T1.5_01994 330214.NIDE2306 0.0 1234.6 Nitrospirae flhA ko:K02400 ko02040,map02040 ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 Bacteria 3J0B1@40117,COG1298@1,COG1298@2 NA|NA|NA N Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin MAG.T1.5_01995 330214.NIDE2307 1.8e-181 642.1 Nitrospirae flhF ko:K02404 ko00000,ko02035 Bacteria 3J162@40117,COG1419@1,COG1419@2 NA|NA|NA N SRP54-type protein, GTPase domain MAG.T1.5_01996 330214.NIDE2308 3.2e-145 521.2 Nitrospirae fleN ko:K02282,ko:K04562 ko00000,ko02035,ko02044 Bacteria 3J0JR@40117,COG0455@1,COG0455@2 NA|NA|NA D Cellulose biosynthesis protein BcsQ MAG.T1.5_01997 330214.NIDE2309 1.1e-125 456.1 Nitrospirae fliA ko:K02405,ko:K03093 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 ko00000,ko00001,ko02035,ko03021 Bacteria 3J0NW@40117,COG1191@1,COG1191@2 NA|NA|NA K Sigma-70, region 4 MAG.T1.5_01998 330214.NIDE2310 9.8e-70 270.4 Bacteria 2.7.7.65 ko:K13590 ko04112,map04112 ko00000,ko00001,ko01000 Bacteria COG2199@1,COG3706@2 NA|NA|NA T diguanylate cyclase activity MAG.T1.5_01999 330214.NIDE2311 8.4e-118 429.9 Nitrospirae flgF ko:K02391,ko:K02392 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 3J16I@40117,COG4786@1,COG4786@2 NA|NA|NA N Flagellar basal body rod FlgEFG protein C-terminal MAG.T1.5_02000 330214.NIDE2312 4e-139 500.7 Nitrospirae flgG ko:K02392 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 3J0IQ@40117,COG4786@1,COG4786@2 NA|NA|NA N Flagellar basal body rod FlgEFG protein C-terminal MAG.T1.5_02001 330214.NIDE2313 3.8e-113 414.5 Bacteria flgA ko:K02279,ko:K02386 ko02040,map02040 ko00000,ko00001,ko02035,ko02044 Bacteria COG1261@1,COG1261@2 NA|NA|NA N bacterial-type flagellum organization MAG.T1.5_02002 330214.NIDE2314 5.9e-107 393.7 Nitrospirae flgH ko:K01991,ko:K02393 ko02026,ko02040,map02026,map02040 ko00000,ko00001,ko02000,ko02035 1.B.18 Bacteria 3J16G@40117,COG2063@1,COG2063@2 NA|NA|NA N Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation MAG.T1.5_02003 330214.NIDE2315 1.4e-205 722.2 Nitrospirae flgI ko:K02394 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 3J0MB@40117,COG1706@1,COG1706@2 NA|NA|NA N Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation MAG.T1.5_02004 330214.NIDE2316 2e-36 158.3 Bacteria flgJ ko:K02395,ko:K08309 ko00000,ko01000,ko01011,ko02035 GH23 Bacteria COG3951@1,COG3951@2 NA|NA|NA MNO Flagellar rod assembly protein muramidase FlgJ MAG.T1.5_02005 330214.NIDE2317 5.3e-39 166.8 Bacteria flgM GO:0000988,GO:0000989,GO:0003674,GO:0008150,GO:0009889,GO:0009892,GO:0010556,GO:0010605,GO:0016989,GO:0019219,GO:0019222,GO:0030162,GO:0031323,GO:0031324,GO:0031326,GO:0032268,GO:0032269,GO:0045861,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141 ko:K02398 ko02020,ko02025,ko02026,ko02040,map02020,map02025,map02026,map02040 ko00000,ko00001,ko02035 Bacteria COG2747@1,COG2747@2 NA|NA|NA N bacterial-type flagellum organization MAG.T1.5_02007 330214.NIDE2319 1.2e-223 782.3 Nitrospirae flgK ko:K02396 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 3J0M9@40117,COG1256@1,COG1256@2,COG4786@1,COG4786@2 NA|NA|NA N Flagellar basal body rod FlgEFG protein C-terminal MAG.T1.5_02008 330214.NIDE2320 6.6e-138 496.9 Nitrospirae flgL ko:K02397 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 3J0VI@40117,COG1344@1,COG1344@2 NA|NA|NA N Bacterial flagellin N-terminal helical region MAG.T1.5_02009 330214.NIDE2321 4.7e-38 163.3 Bacteria csrA ko:K03563,ko:K13626 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 ko00000,ko00001,ko02035,ko03019 Bacteria COG1551@1,COG1551@2 NA|NA|NA T Could accelerate the degradation of some genes transcripts potentially through selective RNA binding MAG.T1.5_02010 330214.NIDE2322 4.5e-60 237.3 Nitrospirae fliW ko:K13626 ko00000,ko02035 Bacteria 3J0V2@40117,COG1699@1,COG1699@2 NA|NA|NA S Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum MAG.T1.5_02011 330214.NIDE2323 0.0 1441.4 Nitrospirae Bacteria 3J0ZF@40117,COG0642@1,COG0784@1,COG0784@2,COG2198@1,COG2198@2,COG2205@2 NA|NA|NA T PhoQ Sensor MAG.T1.5_02012 330214.NIDE2324 7.8e-161 573.5 Nitrospirae Bacteria 3J14V@40117,COG2206@1,COG2206@2 NA|NA|NA T Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_02013 330214.NIDE2325 1.9e-95 355.5 Bacteria Bacteria COG5581@1,COG5581@2 NA|NA|NA M regulation of bacterial-type flagellum-dependent cell motility by regulation of motor speed MAG.T1.5_02014 330214.NIDE2326 3.3e-209 734.2 Bacteria 1.17.1.1 ko:K12452 ko00520,map00520 R03391,R03392 RC00230 ko00000,ko00001,ko01000 Bacteria COG0399@1,COG0399@2 NA|NA|NA E UDP-4-amino-4-deoxy-L-arabinose aminotransferase MAG.T1.5_02016 330214.NIDE2327 8.4e-168 596.3 Bacteria Bacteria COG0451@1,COG0451@2 NA|NA|NA GM ADP-glyceromanno-heptose 6-epimerase activity MAG.T1.5_02017 330214.NIDE2328 1e-185 656.0 Bacteria lmbP 2.7.1.168 ko:K07031 ko00540,map00540 R09770 RC00002,RC00078 ko00000,ko00001,ko01000 Bacteria COG2605@1,COG2605@2 NA|NA|NA G GHMP kinase MAG.T1.5_02018 330214.NIDE2329 5.1e-78 297.7 Bacteria 2.7.7.71,3.1.3.82,3.1.3.83 ko:K03273,ko:K15669 ko00540,ko01100,map00540,map01100 M00064 R05647,R09771,R09772 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 Bacteria COG1208@1,COG1208@2 NA|NA|NA JM COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon MAG.T1.5_02019 1244869.H261_02826 2e-62 246.1 Rhodospirillales 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 Bacteria 1MWRX@1224,2JSGM@204441,2TRA2@28211,COG3959@1,COG3959@2 NA|NA|NA G COG3959 Transketolase, N-terminal subunit MAG.T1.5_02020 1430440.MGMSRv2_4181 2.1e-68 266.2 Rhodospirillales tktC 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 Bacteria 1MWIX@1224,2JYPW@204441,2U2QX@28211,COG3958@1,COG3958@2 NA|NA|NA G Transketolase, pyrimidine binding domain MAG.T1.5_02021 118166.JH976537_gene4476 8.6e-178 630.2 Oscillatoriales Bacteria 1G3ZK@1117,1HH76@1150,COG1032@1,COG1032@2 NA|NA|NA C Elongator protein 3, MiaB family, Radical SAM MAG.T1.5_02022 330214.NIDE2334 0.0 1650.2 Bacteria celD ko:K02453,ko:K07280,ko:K20444,ko:K20543 ko03070,ko05111,map03070,map05111 M00331 ko00000,ko00001,ko00002,ko01000,ko01005,ko02000,ko02044 1.B.55.3,3.A.15,4.D.1.3 GT2,GT4 Bacteria COG0438@1,COG0438@2,COG1215@1,COG1215@2,COG1216@1,COG1216@2,COG2227@1,COG2227@2,COG3118@1,COG3118@2 NA|NA|NA O belongs to the thioredoxin family MAG.T1.5_02023 330214.NIDE2335 2.7e-113 415.2 Bacteria ko:K02843,ko:K02849 ko00540,ko01100,map00540,map01100 M00080 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 GT9 Bacteria COG0859@1,COG0859@2 NA|NA|NA M ADP-heptose-lipopolysaccharide heptosyltransferase activity MAG.T1.5_02024 330214.NIDE2336 1e-270 939.1 Nitrospirae cgeB ko:K06320 ko00000 Bacteria 3J0ZZ@40117,COG4641@1,COG4641@2 NA|NA|NA S DUF based on E. rectale Gene description (DUF3880) MAG.T1.5_02025 330214.NIDE2337 1.6e-249 868.6 Nitrospirae ko:K02843,ko:K02849 ko00540,ko01100,map00540,map01100 M00080 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 GT9 Bacteria 3J197@40117,COG0859@1,COG0859@2 NA|NA|NA M Glycosyltransferase family 9 (heptosyltransferase) MAG.T1.5_02027 330214.NIDE2339 8.5e-132 476.5 Nitrospirae fliC ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 ko00000,ko00001,ko02035 Bacteria 3J0UP@40117,COG1344@1,COG1344@2 NA|NA|NA N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella MAG.T1.5_02028 330214.NIDE2340 6.8e-41 173.3 Bacteria flaG ko:K06603 ko00000,ko02035 Bacteria COG1334@1,COG1334@2 NA|NA|NA N flagellar protein FlaG MAG.T1.5_02029 330214.NIDE2341 5.9e-202 710.3 Nitrospirae fliD GO:0001539,GO:0003674,GO:0005198,GO:0005575,GO:0005576,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009420,GO:0009421,GO:0009424,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588 ko:K02407 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 3J0S1@40117,COG1345@1,COG1345@2 NA|NA|NA N Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end MAG.T1.5_02030 330214.NIDE2342 7.5e-62 243.0 Nitrospirae fliS GO:0001539,GO:0003674,GO:0005198,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588 ko:K02422 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 3J1A2@40117,COG1516@1,COG1516@2 NA|NA|NA N Flagellar protein FliS MAG.T1.5_02032 1206777.B195_19636 1.1e-08 67.0 Pseudomonas syringae group pilZ_1 Bacteria 1N7P9@1224,1SCEA@1236,1Z6GB@136849,2E62S@1,330RV@2 NA|NA|NA S PilZ domain MAG.T1.5_02033 330214.NIDE2345 1.3e-160 572.4 Bacteria ylxH-3 ko:K04562 ko00000,ko02035 Bacteria COG0455@1,COG0455@2 NA|NA|NA D bacterial-type flagellum organization MAG.T1.5_02034 330214.NIDE2346 4.9e-27 127.1 Bacteria ko:K02806 ko02060,map02060 ko00000,ko00001,ko01000,ko02000 Bacteria COG3311@1,COG3311@2 NA|NA|NA K DNA excision MAG.T1.5_02035 330214.NIDE2347 2.2e-151 541.6 Nitrospirae cheR 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 ko00000,ko00001,ko01000,ko02035 Bacteria 3J0XI@40117,COG1352@1,COG1352@2 NA|NA|NA NT Chemotaxis protein methyltransferase MAG.T1.5_02036 330214.NIDE2348 1.4e-57 228.8 Nitrospirae Bacteria 3J1FT@40117,COG0745@1,COG0745@2 NA|NA|NA T cheY-homologous receiver domain MAG.T1.5_02037 330214.NIDE2349 7.2e-94 350.1 Nitrospirae ko:K03414 ko02030,map02030 ko00000,ko00001,ko02035 Bacteria 3J1AW@40117,COG3143@1,COG3143@2 NA|NA|NA NT Chemotaxis phosphatase, CheZ MAG.T1.5_02038 330214.NIDE2350 2.7e-290 1004.2 Nitrospirae cheA 2.7.13.3 ko:K02487,ko:K03407,ko:K06596 ko02020,ko02025,ko02030,map02020,map02025,map02030 M00506,M00507 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 Bacteria 3J0BG@40117,COG0643@1,COG0643@2,COG2198@1,COG2198@2 NA|NA|NA NT Evidence 2a Function of homologous gene experimentally demonstrated in an other organism MAG.T1.5_02039 330214.NIDE2351 5.1e-168 597.0 Nitrospirae cheV 2.7.13.3 ko:K03407,ko:K03408,ko:K03415 ko02020,ko02030,map02020,map02030 M00506 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 Bacteria 3J14W@40117,COG0784@1,COG0784@2,COG0835@1,COG0835@2 NA|NA|NA T Two component signalling adaptor domain MAG.T1.5_02040 330214.NIDE2352 1.2e-186 659.1 Nitrospirae cheB 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 Bacteria 3J0X3@40117,COG2201@1,COG2201@2 NA|NA|NA NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR MAG.T1.5_02042 330214.NIDE2353 1.8e-183 649.0 Nitrospirae mcp40H-4 ko:K03406,ko:K07216 ko02020,ko02030,map02020,map02030 ko00000,ko00001,ko02035 Bacteria 3J0N9@40117,COG0840@1,COG0840@2 NA|NA|NA NT Methyl-accepting chemotaxis protein MAG.T1.5_02043 330214.NIDE2354 1.6e-72 278.9 Nitrospirae cheW40H-1 ko:K03408,ko:K03415 ko02020,ko02030,map02020,map02030 M00506 ko00000,ko00001,ko00002,ko02022,ko02035 Bacteria 3J0PG@40117,COG0835@1,COG0835@2 NA|NA|NA NT Evidence 2a Function of homologous gene experimentally demonstrated in an other organism MAG.T1.5_02045 330214.NIDE2356 6.3e-129 466.8 Nitrospirae motC ko:K02556 ko02020,ko02030,ko02040,map02020,map02030,map02040 ko00000,ko00001,ko02000,ko02035 1.A.30.1 Bacteria 3J0KF@40117,COG1291@1,COG1291@2 NA|NA|NA N MotA/TolQ/ExbB proton channel family MAG.T1.5_02046 330214.NIDE2357 7.3e-133 479.9 Nitrospirae motB ko:K02557 ko02030,ko02040,map02030,map02040 ko00000,ko00001,ko02000,ko02035 1.A.30.1 Bacteria 3J0MN@40117,COG1360@1,COG1360@2 NA|NA|NA N Membrane MotB of proton-channel complex MotA/MotB MAG.T1.5_02048 330214.NIDE2359 8.2e-146 523.5 Bacteria ko:K03406 ko02020,ko02030,map02020,map02030 ko00000,ko00001,ko02035 Bacteria COG0840@1,COG0840@2 NA|NA|NA NT transmembrane signaling receptor activity MAG.T1.5_02049 330214.NIDE2360 2.5e-59 234.6 Nitrospirae Bacteria 3J18A@40117,COG0745@1,COG0745@2 NA|NA|NA T cheY-homologous receiver domain MAG.T1.5_02050 330214.NIDE2361 0.0 1124.8 Nitrospirae cheA GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006935,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009892,GO:0009893,GO:0009987,GO:0010562,GO:0010604,GO:0010605,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019220,GO:0019222,GO:0019538,GO:0019904,GO:0023014,GO:0023052,GO:0031323,GO:0031324,GO:0031325,GO:0031399,GO:0031400,GO:0031401,GO:0032101,GO:0032268,GO:0032269,GO:0032270,GO:0032879,GO:0032991,GO:0035303,GO:0035304,GO:0035306,GO:0035307,GO:0035556,GO:0036211,GO:0040011,GO:0040012,GO:0042221,GO:0042330,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0045937,GO:0046777,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0050920,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051179,GO:0051234,GO:0051246,GO:0051247,GO:0051248,GO:0051270,GO:0051641,GO:0051649,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0098561,GO:0140096,GO:1901564,GO:1901873,GO:1901875,GO:1902021,GO:2000145 2.7.13.3 ko:K02487,ko:K03407,ko:K06596 ko02020,ko02025,ko02030,map02020,map02025,map02030 M00506,M00507 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 Bacteria 3J0BG@40117,COG0643@1,COG0643@2,COG2198@1,COG2198@2 NA|NA|NA NT Evidence 2a Function of homologous gene experimentally demonstrated in an other organism MAG.T1.5_02051 330214.NIDE2362 2.6e-83 314.7 Nitrospirae cheW GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006935,GO:0007154,GO:0007165,GO:0008150,GO:0009605,GO:0009893,GO:0009987,GO:0010604,GO:0016020,GO:0019222,GO:0019904,GO:0023052,GO:0031323,GO:0031325,GO:0031399,GO:0031401,GO:0032268,GO:0032270,GO:0032991,GO:0040011,GO:0042221,GO:0042330,GO:0044424,GO:0044444,GO:0044464,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051179,GO:0051234,GO:0051246,GO:0051247,GO:0051641,GO:0051649,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0098561,GO:1901873,GO:1901875 ko:K03408,ko:K03415 ko02020,ko02030,map02020,map02030 M00506 ko00000,ko00001,ko00002,ko02022,ko02035 Bacteria 3J0PG@40117,COG0835@1,COG0835@2 NA|NA|NA NT Evidence 2a Function of homologous gene experimentally demonstrated in an other organism MAG.T1.5_02052 330214.NIDE2363 0.0 1256.5 Bacteria bdlA ko:K03406 ko02020,ko02030,map02020,map02030 ko00000,ko00001,ko02035 Bacteria COG0840@1,COG0840@2,COG1017@1,COG1017@2,COG2202@1,COG2202@2 NA|NA|NA C nitric oxide dioxygenase activity MAG.T1.5_02053 330214.NIDE2364 3.1e-75 287.7 Nitrospirae ko:K08976 ko00000 Bacteria 3J1D2@40117,COG2322@1,COG2322@2 NA|NA|NA S Protein of unknown function (DUF420) MAG.T1.5_02054 330214.NIDE2365 1.5e-144 518.8 Nitrospirae cheR GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006479,GO:0006807,GO:0006935,GO:0008022,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0008983,GO:0009605,GO:0009987,GO:0010340,GO:0016020,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0032991,GO:0036211,GO:0040011,GO:0042221,GO:0042330,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051998,GO:0071704,GO:0071944,GO:0098561,GO:0140096,GO:1901564 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 ko00000,ko00001,ko01000,ko02035 Bacteria 3J0XI@40117,COG1352@1,COG1352@2 NA|NA|NA NT Chemotaxis protein methyltransferase MAG.T1.5_02055 330214.NIDE2366 1.2e-101 375.9 Bacteria cheD GO:0006935,GO:0008150,GO:0009605,GO:0040011,GO:0042221,GO:0042330,GO:0050896 3.1.1.61,3.5.1.44 ko:K03411,ko:K03412 ko02020,ko02030,map02020,map02030 M00506 ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 Bacteria COG1871@1,COG1871@2 NA|NA|NA NT Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis MAG.T1.5_02056 330214.NIDE2367 6.5e-169 600.1 Nitrospirae cheB 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 Bacteria 3J0X3@40117,COG2201@1,COG2201@2 NA|NA|NA NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR MAG.T1.5_02057 330214.NIDE2368 6.5e-38 163.3 Bacteria ko:K04749,ko:K17763 ko00000,ko03021 Bacteria COG1366@1,COG1366@2 NA|NA|NA T antisigma factor binding MAG.T1.5_02058 330214.NIDE2369 6.5e-41 173.3 Bacteria IV02_16530 Bacteria COG1366@1,COG1366@2 NA|NA|NA T antisigma factor binding MAG.T1.5_02059 330214.NIDE2370 3.6e-182 644.4 Bacteria 3.1.3.3 ko:K07315 ko00000,ko01000,ko03021 Bacteria COG0745@1,COG0745@2,COG2208@1,COG2208@2 NA|NA|NA T phosphoserine phosphatase activity MAG.T1.5_02060 330214.NIDE2371 1.2e-34 152.5 Bacteria ko:K20976 ko02020,ko02025,map02020,map02025 M00820 ko00000,ko00001,ko00002,ko02022 Bacteria COG2198@1,COG2198@2 NA|NA|NA T Histidine kinase MAG.T1.5_02061 330214.NIDE2372 3.2e-108 398.3 Bacteria cpaE 2.7.11.1,2.7.13.3 ko:K02282,ko:K02482,ko:K04757,ko:K20977 ko02020,ko02025,map02020,map02025 M00820 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035,ko02044,ko03021 Bacteria COG2172@1,COG2172@2,COG2204@1,COG2204@2 NA|NA|NA T sigma factor antagonist activity MAG.T1.5_02064 330214.NIDE2377 4.2e-187 660.6 Nitrospirae wecB 3.2.1.184,5.1.3.14 ko:K01791,ko:K18429 ko00520,ko01100,ko05111,map00520,map01100,map05111 M00362 R00420,R10187 RC00005,RC00288,RC00290 ko00000,ko00001,ko00002,ko01000,ko01005 Bacteria 3J148@40117,COG0381@1,COG0381@2 NA|NA|NA M Belongs to the UDP-N-acetylglucosamine 2-epimerase family MAG.T1.5_02066 330214.NIDE2379 1.3e-45 188.7 Bacteria ko:K09803 ko00000 Bacteria COG2929@1,COG2929@2 NA|NA|NA S Ribonuclease toxin, BrnT, of type II toxin-antitoxin system MAG.T1.5_02067 1382359.JIAL01000001_gene240 3.2e-72 278.9 Bacteria ko:K07133 ko00000 Bacteria COG1373@1,COG1373@2 NA|NA|NA V ATPase (AAA superfamily MAG.T1.5_02069 221288.JH992901_gene2711 1.7e-16 91.7 Stigonemataceae Bacteria 1G9J8@1117,1JJ0Y@1189,COG2002@1,COG2002@2 NA|NA|NA K SpoVT / AbrB like domain MAG.T1.5_02070 396588.Tgr7_2443 6.2e-32 143.7 Gammaproteobacteria vapC Bacteria 1N9JM@1224,1SYAP@1236,COG5611@1,COG5611@2 NA|NA|NA S PIN domain MAG.T1.5_02071 330214.NIDE2386 3.3e-240 837.8 Bacteria Bacteria COG5360@1,COG5360@2 NA|NA|NA S Heparinase II/III-like protein MAG.T1.5_02072 330214.NIDE3012 1.4e-160 572.4 Nitrospirae gmd 4.2.1.47 ko:K01711 ko00051,ko00520,ko01100,map00051,map00520,map01100 R00888 RC00402 ko00000,ko00001,ko01000 Bacteria 3J0YR@40117,COG1089@1,COG1089@2 NA|NA|NA M Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose MAG.T1.5_02073 335543.Sfum_0979 1.2e-54 219.9 Deltaproteobacteria ko:K01991 ko02026,map02026 ko00000,ko00001,ko02000 1.B.18 Bacteria 1RDXY@1224,2X6GD@28221,43DN5@68525,COG1596@1,COG1596@2 NA|NA|NA M PFAM Polysaccharide export protein MAG.T1.5_02074 338966.Ppro_2880 1.1e-92 347.4 Deltaproteobacteria ko:K07011,ko:K16554,ko:K20998 ko02025,ko05111,map02025,map05111 ko00000,ko00001,ko02000 8.A.3.1 Bacteria 1R7T2@1224,2WNVQ@28221,42S8V@68525,COG3206@1,COG3206@2 NA|NA|NA M PFAM lipopolysaccharide biosynthesis MAG.T1.5_02075 335543.Sfum_0976 4.8e-33 148.3 Syntrophobacterales sypD Bacteria 1MYGS@1224,2MRPK@213462,2WP72@28221,42T04@68525,COG0489@1,COG0489@2 NA|NA|NA D protein tyrosine kinase activity MAG.T1.5_02076 395961.Cyan7425_0816 4.2e-61 242.7 Cyanobacteria 5.1.3.37 ko:K01795,ko:K20276 ko00051,ko02024,map00051,map02024 R08693 RC00509 ko00000,ko00001,ko01000 Bacteria 1G13S@1117,COG3420@1,COG3420@2 NA|NA|NA P TIGRFAM parallel beta-helix repeat (two copies) MAG.T1.5_02077 99598.Cal7507_4101 4.2e-83 315.1 Nostocales rfaG3 Bacteria 1G1X1@1117,1HMU6@1161,COG0438@1,COG0438@2 NA|NA|NA M PFAM Glycosyl transferases group 1 MAG.T1.5_02078 56780.SYN_01102 2e-11 77.4 Bacteria ko:K02847,ko:K13009 ko00540,ko01100,map00540,map01100 M00080 ko00000,ko00001,ko00002,ko01000,ko01005,ko02000 9.B.67.4,9.B.67.5 Bacteria COG3307@1,COG3307@2 NA|NA|NA M -O-antigen MAG.T1.5_02079 927677.ALVU02000001_gene2194 7.2e-122 444.1 Cyanobacteria Bacteria 1G0EX@1117,COG0438@1,COG0438@2 NA|NA|NA M PFAM Glycosyl transferases group 1 MAG.T1.5_02080 319795.Dgeo_2504 3.8e-52 212.2 Bacteria 2.7.1.89 ko:K07251 ko00730,ko01100,map00730,map01100 R02134 RC00002,RC00017 ko00000,ko00001,ko01000 Bacteria COG0510@1,COG0510@2 NA|NA|NA M ethanolamine kinase activity MAG.T1.5_02081 266264.Rmet_0480 7.6e-120 436.8 Burkholderiaceae ko:K07493 ko00000 Bacteria 1K2MR@119060,1MU4P@1224,2VKD6@28216,COG3328@1,COG3328@2 NA|NA|NA L PFAM transposase mutator type MAG.T1.5_02082 1268622.AVS7_03622 1.7e-41 175.6 Comamonadaceae ko:K07493 ko00000 Bacteria 1MU4P@1224,2VKD6@28216,4AF3N@80864,COG3328@1,COG3328@2 NA|NA|NA L PFAM transposase, mutator type MAG.T1.5_02083 319795.Dgeo_2503 1.1e-88 334.0 Bacteria tmk 2.1.1.45,2.7.4.9 ko:K00560,ko:K00943 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02094,R02098,R02101 RC00002,RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 Bacteria COG0125@1,COG0125@2 NA|NA|NA F dTDP biosynthetic process MAG.T1.5_02084 643473.KB235930_gene330 5.9e-102 377.9 Nostocales Bacteria 1G32B@1117,1HQ1N@1161,COG0438@1,COG0438@2 NA|NA|NA M Glycosyl transferases group 1 MAG.T1.5_02085 319795.Dgeo_2502 8.9e-32 144.8 Deinococcus-Thermus Bacteria 1WKII@1297,COG2244@1,COG2244@2 NA|NA|NA S polysaccharide biosynthetic process MAG.T1.5_02086 983548.Krodi_2049 2.1e-19 103.2 Dokdonia Bacteria 1IKIT@117743,37FKC@326319,4PPD8@976,COG4076@1,COG4076@2 NA|NA|NA S Methyltransferase FkbM domain MAG.T1.5_02087 690850.Desaf_1151 8.5e-76 290.4 Desulfovibrionales rffM 2.4.1.187 ko:K05946 ko05111,map05111 ko00000,ko00001,ko01000,ko01003 GT26 Bacteria 1N1HD@1224,2MCZ7@213115,2WQSK@28221,42TWK@68525,COG1922@1,COG1922@2 NA|NA|NA M Glycosyl transferase WecB/TagA/CpsF family MAG.T1.5_02088 880072.Desac_1327 7.4e-115 421.0 Syntrophobacterales Bacteria 1MV6W@1224,2MRYR@213462,2WJWT@28221,42MZY@68525,COG1086@1,COG1086@2,COG2148@1,COG2148@2 NA|NA|NA M Undecaprenyl-phosphate galactose phosphotransferase MAG.T1.5_02089 330214.NIDE2410 0.0 1144.0 Nitrospirae ko:K02030 M00236 ko00000,ko00002,ko02000 3.A.1.3 Bacteria 3J0WC@40117,COG0673@1,COG0673@2,COG1063@1,COG1063@2 NA|NA|NA C Oxidoreductase family, NAD-binding Rossmann fold MAG.T1.5_02090 330214.NIDE2411 2.9e-212 744.6 Bacteria exeA ko:K02450 M00331 ko00000,ko00002,ko02044 9.B.42 Bacteria COG0457@1,COG0457@2,COG3267@1,COG3267@2 NA|NA|NA S peptidyl-tyrosine sulfation MAG.T1.5_02091 330214.NIDE2426 2e-33 149.4 Nitrospirae Bacteria 3J0JU@40117,COG0745@1,COG0745@2 NA|NA|NA K Transcriptional regulatory protein, C terminal MAG.T1.5_02092 330214.NIDE2413 7.9e-61 240.7 Bacteria sixA-2 ko:K08296 ko00000,ko01000 Bacteria COG5607@1,COG5607@2 NA|NA|NA F PFAM CHAD domain containing protein MAG.T1.5_02093 330214.NIDE2414 1.3e-58 232.6 Bacteria sixA ko:K08296 ko00000,ko01000 Bacteria COG2062@1,COG2062@2 NA|NA|NA T phosphohistidine phosphatase, SixA MAG.T1.5_02094 330214.NIDE2415 1.4e-252 878.6 Nitrospirae ppx 3.6.1.11,3.6.1.40 ko:K01524,ko:K07012 ko00230,map00230 R03409 RC00002 ko00000,ko00001,ko01000,ko02048 Bacteria 3J0K5@40117,COG0248@1,COG0248@2,COG2206@1,COG2206@2 NA|NA|NA FP Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_02095 330214.NIDE2416 1.6e-112 412.1 Nitrospirae phoU GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010468,GO:0010563,GO:0010605,GO:0010629,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0060255,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 ko:K02039 ko00000 Bacteria 3J0M6@40117,COG0704@1,COG0704@2 NA|NA|NA P Plays a role in the regulation of phosphate uptake MAG.T1.5_02096 330214.NIDE2417 5e-135 487.3 Nitrospirae pstB 3.6.3.27 ko:K02036 ko02010,map02010 M00222 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 Bacteria 3J0EU@40117,COG1117@1,COG1117@2 NA|NA|NA P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system MAG.T1.5_02097 330214.NIDE2418 6.9e-242 843.2 Nitrospirae pstA ko:K02038 ko02010,map02010 M00222 ko00000,ko00001,ko00002,ko02000 3.A.1.7 Bacteria 3J0SE@40117,COG0581@1,COG0581@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component MAG.T1.5_02098 330214.NIDE2419 0.0 1177.5 Bacteria pstC ko:K02037,ko:K02038 ko02010,map02010 M00222 ko00000,ko00001,ko00002,ko02000 3.A.1.7 Bacteria COG4590@1,COG4590@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component MAG.T1.5_02099 330214.NIDE2420 6.4e-150 537.0 Bacteria pstS ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 ko00000,ko00001,ko00002,ko02000 3.A.1.7 Bacteria COG0226@1,COG0226@2 NA|NA|NA P phosphate ion binding MAG.T1.5_02100 330214.NIDE2426 1.7e-67 262.7 Nitrospirae Bacteria 3J0JU@40117,COG0745@1,COG0745@2 NA|NA|NA K Transcriptional regulatory protein, C terminal MAG.T1.5_02101 1437448.AZRT01000113_gene4320 2.8e-25 120.9 Proteobacteria ko:K07090 ko00000 Bacteria 1RBHH@1224,COG0730@1,COG0730@2 NA|NA|NA S membrane transporter protein MAG.T1.5_02102 595494.Tola_1286 2.8e-215 755.0 Gammaproteobacteria pykF4 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 Bacteria 1NNNX@1224,1RYF5@1236,COG0469@1,COG0469@2 NA|NA|NA G Pyruvate kinase MAG.T1.5_02104 330214.NIDE2428 1.2e-59 236.1 Nitrospirae pacB Bacteria 3J1A3@40117,COG3431@1,COG3431@2 NA|NA|NA S Phosphate-starvation-inducible E MAG.T1.5_02106 330214.NIDE2431 1.5e-78 300.1 Bacteria pstS ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 ko00000,ko00001,ko00002,ko02000 3.A.1.7 Bacteria COG0226@1,COG0226@2 NA|NA|NA P phosphate ion binding MAG.T1.5_02108 330214.NIDE2435 1.2e-147 530.0 Bacteria Bacteria COG3746@1,COG3746@2 NA|NA|NA MAG.T1.5_02109 110319.CF8_3295 1.4e-34 153.3 Propionibacteriales Bacteria 2GKFS@201174,4DNN6@85009,COG0745@1,COG0745@2 NA|NA|NA T Transcriptional regulatory protein, C terminal MAG.T1.5_02110 330214.NIDE2438 4.9e-58 230.3 Nitrospirae ko:K10716 ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 Bacteria 3J0UW@40117,COG2905@1,COG2905@2 NA|NA|NA T Domain in cystathionine beta-synthase and other proteins. MAG.T1.5_02111 330214.NIDE2439 8.9e-88 329.7 Nitrospirae pal ko:K03640 ko00000,ko02000 2.C.1.2 Bacteria 3J17Q@40117,COG2885@1,COG2885@2 NA|NA|NA M Belongs to the ompA family MAG.T1.5_02112 324057.Pjdr2_3164 2.3e-240 839.7 Paenibacillaceae Bacteria 1VRZ7@1239,26SSG@186822,4I6FJ@91061,COG3391@1,COG3391@2 NA|NA|NA S PFAM NHL repeat containing protein MAG.T1.5_02113 1116472.MGMO_136c00050 2.7e-148 531.9 Methylococcales ko:K03309 ko00000 2.A.23 Bacteria 1MU0Q@1224,1RMEN@1236,1XFDA@135618,COG1301@1,COG1301@2 NA|NA|NA U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family MAG.T1.5_02119 330214.NIDE2802 4.5e-102 377.5 Bacteria Bacteria 28NM7@1,2ZBMT@2 NA|NA|NA S Protein of unknown function (DUF2959) MAG.T1.5_02121 330214.NIDE3674 9.6e-96 356.7 Bacteria 3.6.1.27 ko:K19302 ko00550,map00550 R05627 RC00002 ko00000,ko00001,ko01000,ko01011 Bacteria COG0671@1,COG0671@2 NA|NA|NA I phosphatidate phosphatase activity MAG.T1.5_02129 330214.NIDE2813 2.6e-44 184.9 Bacteria yuxK Bacteria COG3011@1,COG3011@2 NA|NA|NA CH Protein conserved in bacteria MAG.T1.5_02130 330214.NIDE2788 8.3e-85 319.7 Bacteria Bacteria 2EBKA@1,335KQ@2 NA|NA|NA MAG.T1.5_02131 1297742.A176_05408 4.4e-55 221.5 Myxococcales Bacteria 1MURA@1224,2X6F0@28221,2YXND@29,42RGG@68525,COG0491@1,COG0491@2 NA|NA|NA P COG0491 Zn-dependent hydrolases, including glyoxylases MAG.T1.5_02132 330214.NIDE3480 3.8e-63 247.7 Nitrospirae MA20_44930 2.1.1.222,2.1.1.64 ko:K00568 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04988,R05614,R08769,R08781 RC00003,RC00392,RC01895 ko00000,ko00001,ko00002,ko01000 Bacteria 3J19H@40117,COG3865@1,COG3865@2 NA|NA|NA H 3-demethylubiquinone-9 3-methyltransferase MAG.T1.5_02134 330214.NIDE1069 5.6e-35 153.3 Bacteria Bacteria 2DJBU@1,32UCQ@2 NA|NA|NA MAG.T1.5_02135 1336243.JAEA01000003_gene2422 2.4e-32 145.2 Methylobacteriaceae nudF 3.6.1.13,3.6.1.55 ko:K01515,ko:K03574 ko00230,map00230 R01054 RC00002 ko00000,ko00001,ko01000,ko03400 Bacteria 1JYK8@119045,1N1KH@1224,2UA1K@28211,COG1051@1,COG1051@2 NA|NA|NA F NUDIX domain MAG.T1.5_02137 330214.NIDE2799 3.6e-106 391.0 Bacteria yrdA ko:K03321 ko00000,ko02000 2.A.53.3 Bacteria COG0663@1,COG0663@2 NA|NA|NA G COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily MAG.T1.5_02138 240015.ACP_1401 6.2e-131 474.2 Acidobacteriia ilvA 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 iLJ478.TM0356 Bacteria 2JHRQ@204432,3Y2RI@57723,COG1171@1,COG1171@2 NA|NA|NA E PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit MAG.T1.5_02141 330214.NIDE3050 2.3e-69 269.6 Bacteria 3.1.3.3 ko:K07315 ko00000,ko01000,ko03021 Bacteria COG2202@1,COG2202@2,COG3829@1,COG3829@2,COG4251@1,COG4251@2 NA|NA|NA T Pas domain MAG.T1.5_02142 330214.NIDE2793 2.8e-23 114.4 Bacteria 4.1.1.44 ko:K01607 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 R03470 RC00938 ko00000,ko00001,ko01000 Bacteria COG0599@1,COG0599@2 NA|NA|NA S peroxiredoxin activity MAG.T1.5_02143 330214.NIDE2794 7e-110 403.7 Bacteria Bacteria COG0500@1,COG2226@2 NA|NA|NA Q methyltransferase MAG.T1.5_02144 330214.NIDE2795 1.7e-134 485.7 Bacteria Bacteria COG4977@1,COG4977@2 NA|NA|NA K sequence-specific DNA binding MAG.T1.5_02146 330214.NIDE2814 2.6e-45 188.3 Nitrospirae Bacteria 3J1F1@40117,COG0607@1,COG0607@2 NA|NA|NA P Rhodanese Homology Domain MAG.T1.5_02147 556263.FSEG_00086 2.9e-09 69.3 Fusobacteria Bacteria 2C4D9@1,33C3U@2,37C2I@32066 NA|NA|NA S Protein of unknown function (DUF1353) MAG.T1.5_02151 330214.NIDE2242 2.9e-163 581.3 Bacteria Bacteria COG0535@1,COG0535@2 NA|NA|NA I radical SAM domain protein MAG.T1.5_02152 330214.NIDE2241 1.7e-162 578.9 Bacteria ko:K03112 ko00000 Bacteria COG3266@1,COG3266@2 NA|NA|NA GM domain, Protein MAG.T1.5_02153 1089545.KB913037_gene9162 2.5e-09 71.2 Actinobacteria 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 Bacteria 2I4WG@201174,COG3064@1,COG3064@2 NA|NA|NA M Domain of unknown function (DUF4157) MAG.T1.5_02155 330214.NIDE2238 0.0 2123.2 Bacteria Bacteria COG4447@1,COG4447@2 NA|NA|NA S cellulose binding MAG.T1.5_02156 330214.NIDE2237 0.0 1272.7 Bacteria Bacteria COG3292@1,COG3292@2 NA|NA|NA MAG.T1.5_02157 330214.NIDE2236 0.0 1358.6 Bacteria Bacteria COG2375@1,COG2375@2 NA|NA|NA P cellular response to nickel ion MAG.T1.5_02158 330214.NIDE2235 0.0 1361.7 Bacteria yqbT1 Bacteria COG3299@1,COG3299@2 NA|NA|NA S Baseplate J-like protein MAG.T1.5_02159 330214.NIDE2234 8.3e-47 193.0 Bacteria ko:K06903 ko00000 Bacteria COG3628@1,COG3628@2 NA|NA|NA MAG.T1.5_02160 330214.NIDE2233 6.6e-48 196.4 Bacteria Bacteria 2CE1N@1,32RYY@2 NA|NA|NA MAG.T1.5_02161 330214.NIDE2232 1.2e-94 352.4 Bacteria Bacteria COG3501@1,COG3501@2 NA|NA|NA T Rhs element vgr protein MAG.T1.5_02162 330214.NIDE2231 7.9e-189 666.4 Bacteria ko:K06905 ko00000 Bacteria COG3500@1,COG3500@2 NA|NA|NA MAG.T1.5_02163 330214.NIDE2230 3.6e-55 220.7 Bacteria ygaU GO:0003674,GO:0005488,GO:0008150,GO:0010035,GO:0010038,GO:0030955,GO:0031420,GO:0035864,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896 Bacteria COG1652@1,COG1652@2 NA|NA|NA S positive regulation of growth rate MAG.T1.5_02164 330214.NIDE2229 3.5e-104 384.4 Bacteria Bacteria 2CI52@1,2ZC5H@2 NA|NA|NA MAG.T1.5_02165 330214.NIDE2228 1.2e-127 463.8 Bacteria Bacteria COG2885@1,COG2885@2 NA|NA|NA M chlorophyll binding MAG.T1.5_02166 330214.NIDE2226 2.7e-38 167.5 Bacteria Bacteria COG2885@1,COG2885@2 NA|NA|NA M chlorophyll binding MAG.T1.5_02167 330214.NIDE2227 2.3e-39 169.1 Bacteria Bacteria COG3409@1,COG3409@2 NA|NA|NA M Peptidoglycan-binding domain 1 protein MAG.T1.5_02168 330214.NIDE2226 1.3e-223 782.3 Bacteria Bacteria COG2885@1,COG2885@2 NA|NA|NA M chlorophyll binding MAG.T1.5_02170 330214.NIDE2224 1.4e-206 726.1 Bacteria 3.6.4.6 ko:K06027 ko04138,ko04721,ko04727,ko04962,map04138,map04721,map04727,map04962 ko00000,ko00001,ko01000,ko04131 1.F.1.1 Bacteria COG0464@1,COG0464@2 NA|NA|NA O ATPase activity MAG.T1.5_02171 330214.NIDE2223 3e-176 624.8 Bacteria Bacteria 28PII@1,2ZC8H@2 NA|NA|NA S Protein of unknown function (DUF4255) MAG.T1.5_02173 330214.NIDE2221 6.8e-88 330.5 Bacteria Bacteria 2AAD4@1,30ZP1@2 NA|NA|NA MAG.T1.5_02174 330214.NIDE2220 6.8e-95 353.2 Bacteria Bacteria 2DB76@1,2Z7JZ@2 NA|NA|NA S phage tail region protein MAG.T1.5_02175 330214.NIDE2219 7.1e-276 956.1 Bacteria ko:K06907 ko00000 Bacteria COG3497@1,COG3497@2 NA|NA|NA S Phage tail sheath protein subtilisin-like domain MAG.T1.5_02177 330214.NIDE2217 5.8e-176 624.0 Bacteria Bacteria COG2204@1,COG2204@2 NA|NA|NA T phosphorelay signal transduction system MAG.T1.5_02179 330214.NIDE2215 1.7e-92 345.9 Bacteria hel GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 Bacteria COG2503@1,COG2503@2 NA|NA|NA M HAD superfamily, subfamily IIIB (Acid phosphatase) MAG.T1.5_02180 330214.NIDE1696 6.4e-31 141.0 Bacteria Bacteria COG1629@1,COG1629@2 NA|NA|NA P transport MAG.T1.5_02182 330214.NIDE2212 0.0 1736.9 Bacteria Bacteria COG1075@1,COG1075@2,COG4995@1,COG4995@2 NA|NA|NA S CHAT domain MAG.T1.5_02187 330214.NIDE2211 3.1e-138 498.0 Bacteria rmlA GO:0000166,GO:0000270,GO:0000287,GO:0001882,GO:0001884,GO:0002134,GO:0003674,GO:0003824,GO:0005488,GO:0006022,GO:0006040,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0019103,GO:0019752,GO:0030203,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044281,GO:0046872,GO:0070569,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564 2.7.7.13,2.7.7.24,2.7.7.99 ko:K00966,ko:K00973,ko:K00992 ko00051,ko00520,ko00521,ko00523,ko00525,ko01100,ko01110,ko01130,map00051,map00520,map00521,map00523,map00525,map01100,map01110,map01130 M00114,M00361,M00362,M00793 R00885,R02328,R11025 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria COG1208@1,COG1208@2 NA|NA|NA JM COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon MAG.T1.5_02188 330214.NIDE2210 3.6e-123 448.4 Bacteria 2.1.1.156,2.1.1.157,2.1.1.209,2.1.1.4 ko:K00543,ko:K16130,ko:K18896,ko:K18897,ko:K21515 ko00260,ko00380,ko01054,ko01100,map00260,map00380,map01054,map01100 M00037 R03130,R04905,R10060,R10061 RC00003,RC00392,RC03038,RC03040 ko00000,ko00001,ko00002,ko01000,ko01008,ko03009 Bacteria COG2890@1,COG2890@2 NA|NA|NA J protein-(glutamine-N5) methyltransferase activity MAG.T1.5_02189 330214.NIDE2209 8e-228 796.2 Nitrospirae proA GO:0003674,GO:0003824,GO:0004350,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 iLJ478.TM0293,iYO844.BSU13130 Bacteria 3J0ET@40117,COG0014@1,COG0014@2 NA|NA|NA E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate MAG.T1.5_02190 330214.NIDE2192 7.8e-76 290.4 Bacteria ko:K07238 ko00000,ko02000 2.A.5.5 Bacteria COG0428@1,COG0428@2 NA|NA|NA P transporter MAG.T1.5_02191 330214.NIDE2190 4e-28 131.0 Bacteria Bacteria COG2207@1,COG2207@2 NA|NA|NA K Transcriptional regulator MAG.T1.5_02192 330214.NIDE2189 5.6e-68 264.6 Bacteria ko:K03832 ko00000,ko02000 2.C.1.1 Bacteria COG0810@1,COG0810@2 NA|NA|NA M energy transducer activity MAG.T1.5_02193 330214.NIDE2188 1.7e-72 278.9 Bacteria ko:K03088,ko:K07165 ko00000,ko03021 Bacteria COG1595@1,COG1595@2 NA|NA|NA K DNA-templated transcription, initiation MAG.T1.5_02194 330214.NIDE2185 2.4e-93 349.0 Bacteria ko:K07165 ko00000 Bacteria COG3712@1,COG3712@2 NA|NA|NA PT iron ion homeostasis MAG.T1.5_02195 330214.NIDE2183 0.0 1458.0 Bacteria ko:K02014 ko00000,ko02000 1.B.14 Bacteria COG4774@1,COG4774@2 NA|NA|NA P siderophore transport MAG.T1.5_02196 330214.NIDE2180 4e-70 271.2 Bacteria ko:K03088 ko00000,ko03021 Bacteria COG1595@1,COG1595@2 NA|NA|NA K DNA-templated transcription, initiation MAG.T1.5_02197 330214.NIDE2179 8.9e-99 367.1 Bacteria ko:K07165 ko00000 Bacteria COG3712@1,COG3712@2 NA|NA|NA PT iron ion homeostasis MAG.T1.5_02198 330214.NIDE2178 0.0 1566.2 Bacteria fecA ko:K16091 ko00000,ko02000 1.B.14.1.14 Bacteria COG4772@1,COG4772@2 NA|NA|NA P TonB-dependent receptor MAG.T1.5_02199 330214.NIDE2177 2.3e-178 631.7 Bacteria Bacteria COG3182@1,COG3182@2 NA|NA|NA E Iron-regulated membrane protein MAG.T1.5_02200 330214.NIDE2176 5.9e-56 223.8 Nitrospirae fur GO:0000976,GO:0001067,GO:0001130,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032991,GO:0032993,GO:0042802,GO:0043565,GO:0044212,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141 ko:K03711 ko00000,ko03000 Bacteria 3J0UN@40117,COG0735@1,COG0735@2 NA|NA|NA P Belongs to the Fur family MAG.T1.5_02201 330214.NIDE2175 1.6e-73 282.3 Bacteria ko:K03088 ko00000,ko03021 Bacteria COG1595@1,COG1595@2 NA|NA|NA K DNA-templated transcription, initiation MAG.T1.5_02202 330214.NIDE2174 1.8e-112 412.5 Bacteria ko:K07165 ko00000 Bacteria COG3712@1,COG3712@2 NA|NA|NA PT iron ion homeostasis MAG.T1.5_02203 330214.NIDE2173 0.0 1394.0 Bacteria ko:K02014 ko00000,ko02000 1.B.14 Bacteria COG4774@1,COG4774@2 NA|NA|NA P siderophore transport MAG.T1.5_02205 330214.NIDE2171 9.4e-15 86.3 Bacteria ko:K02014 ko00000,ko02000 1.B.14 Bacteria COG1629@1,COG1629@2 NA|NA|NA P transport MAG.T1.5_02206 1532557.JL37_02440 3e-21 108.2 Alcaligenaceae ko:K03088 ko00000,ko03021 Bacteria 1N6SV@1224,2VVB6@28216,3T7BC@506,COG1595@1,COG1595@2 NA|NA|NA K Belongs to the sigma-70 factor family. ECF subfamily MAG.T1.5_02207 257310.BB4743 2.4e-43 183.0 Proteobacteria ko:K07165 ko00000 Bacteria 1RHW4@1224,COG3712@1,COG3712@2 NA|NA|NA PT FecR protein MAG.T1.5_02208 330214.NIDE2183 1e-156 560.8 Bacteria ko:K02014 ko00000,ko02000 1.B.14 Bacteria COG4774@1,COG4774@2 NA|NA|NA P siderophore transport MAG.T1.5_02209 1112274.KI911560_gene250 1.2e-107 396.7 Nitrosomonadales Bacteria 1MW2S@1224,2KKTP@206350,2VHU6@28216,COG3182@1,COG3182@2 NA|NA|NA S PepSY-associated TM region MAG.T1.5_02210 1123261.AXDW01000003_gene2029 4.6e-87 328.2 Xanthomonadales ko:K07006 ko00000 Bacteria 1MWG9@1224,1SE6U@1236,1X9X5@135614,COG3576@1,COG3576@2 NA|NA|NA S Pfam:Pyridox_oxidase MAG.T1.5_02212 472759.Nhal_1802 9e-88 331.3 Gammaproteobacteria Bacteria 1NMVC@1224,1SVSQ@1236,COG2138@1,COG2138@2 NA|NA|NA S Cobalamin (vitamin B12) biosynthesis CbiX protein MAG.T1.5_02215 1211115.ALIQ01000245_gene3681 1.3e-40 172.9 Beijerinckiaceae pfrI ko:K03088 ko00000,ko03021 Bacteria 1RFMB@1224,2UFCA@28211,3NCFU@45404,COG1595@1,COG1595@2 NA|NA|NA K Sigma-70 region 2 MAG.T1.5_02216 1207063.P24_01860 5.5e-59 235.0 Rhodospirillales fecR ko:K07165 ko00000 Bacteria 1MZCK@1224,2JS5V@204441,2U7GV@28211,COG3712@1,COG3712@2 NA|NA|NA PT Domain of unknown function (DUF4880) MAG.T1.5_02217 382464.ABSI01000013_gene1893 2.1e-77 297.4 Verrucomicrobiae Bacteria 2IVTP@203494,46V2F@74201,COG4773@1,COG4773@2 NA|NA|NA P TonB dependent receptor MAG.T1.5_02218 330214.NIDE3526 1.3e-32 146.4 Bacteria ko:K03088 ko00000,ko03021 Bacteria COG1595@1,COG1595@2 NA|NA|NA K DNA-templated transcription, initiation MAG.T1.5_02219 330214.NIDE3525 5.2e-59 235.0 Bacteria ko:K07165 ko00000 Bacteria COG3712@1,COG3712@2 NA|NA|NA PT iron ion homeostasis MAG.T1.5_02220 330214.NIDE2183 8.8e-65 254.2 Bacteria ko:K02014 ko00000,ko02000 1.B.14 Bacteria COG4774@1,COG4774@2 NA|NA|NA P siderophore transport MAG.T1.5_02221 251221.35214547 1.5e-78 300.1 Cyanobacteria ko:K02014 ko00000,ko02000 1.B.14 Bacteria 1G3US@1117,COG4773@1,COG4773@2 NA|NA|NA P COGs COG4773 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid MAG.T1.5_02222 287.DR97_5937 2.6e-107 395.6 Pseudomonas aeruginosa group Bacteria 1MW2S@1224,1S0GC@1236,1YKQ2@136841,COG3182@1,COG3182@2 NA|NA|NA S PepSY-associated TM region MAG.T1.5_02223 596153.Alide_0098 2.4e-07 60.8 Comamonadaceae Bacteria 1PUUR@1224,2AEYP@1,2W5RB@28216,314WM@2,4AIKP@80864 NA|NA|NA MAG.T1.5_02225 269796.Rru_A1438 6.1e-25 120.9 Rhodospirillales ko:K03088 ko00000,ko03021 Bacteria 1N6SV@1224,2JZNG@204441,2UA5H@28211,COG1595@1,COG1595@2 NA|NA|NA K ECF sigma factor MAG.T1.5_02226 438753.AZC_4432 1.2e-44 187.2 Xanthobacteraceae ko:K07165 ko00000 Bacteria 1RA2H@1224,2U6IZ@28211,3EZPM@335928,COG3712@1,COG3712@2 NA|NA|NA PT Domain of unknown function (DUF4880) MAG.T1.5_02227 472759.Nhal_1792 1.2e-205 723.4 Chromatiales MA20_29525 ko:K02014 ko00000,ko02000 1.B.14 Bacteria 1QTT0@1224,1RNBT@1236,1WXZV@135613,COG4773@1,COG4773@2 NA|NA|NA P TonB dependent receptor MAG.T1.5_02228 330214.NIDE3526 1.7e-29 136.0 Bacteria ko:K03088 ko00000,ko03021 Bacteria COG1595@1,COG1595@2 NA|NA|NA K DNA-templated transcription, initiation MAG.T1.5_02229 330214.NIDE3525 5.2e-56 224.9 Bacteria ko:K07165 ko00000 Bacteria COG3712@1,COG3712@2 NA|NA|NA PT iron ion homeostasis MAG.T1.5_02230 228410.NE1097 6.8e-297 1026.5 Nitrosomonadales ko:K02014 ko00000,ko02000 1.B.14 Bacteria 1MV0X@1224,2WGH3@28216,374MA@32003,COG4774@1,COG4774@2 NA|NA|NA P TonB-dependent Receptor Plug Domain MAG.T1.5_02231 1123020.AUIE01000037_gene4732 3.9e-160 571.2 Pseudomonas aeruginosa group MA20_29520 Bacteria 1MXGY@1224,1RYZN@1236,1YD2H@136841,COG3182@1,COG3182@2 NA|NA|NA S PepSY-associated TM region MAG.T1.5_02232 330214.NIDE3526 2.7e-27 128.6 Bacteria ko:K03088 ko00000,ko03021 Bacteria COG1595@1,COG1595@2 NA|NA|NA K DNA-templated transcription, initiation MAG.T1.5_02233 330214.NIDE3525 2.8e-57 229.2 Bacteria ko:K07165 ko00000 Bacteria COG3712@1,COG3712@2 NA|NA|NA PT iron ion homeostasis MAG.T1.5_02234 472759.Nhal_1792 5.3e-169 601.7 Chromatiales MA20_29525 ko:K02014 ko00000,ko02000 1.B.14 Bacteria 1QTT0@1224,1RNBT@1236,1WXZV@135613,COG4773@1,COG4773@2 NA|NA|NA P TonB dependent receptor MAG.T1.5_02235 330214.NIDE2173 1.8e-13 81.3 Bacteria ko:K02014 ko00000,ko02000 1.B.14 Bacteria COG4774@1,COG4774@2 NA|NA|NA P siderophore transport MAG.T1.5_02236 330214.NIDE2188 2.3e-25 122.5 Bacteria ko:K03088,ko:K07165 ko00000,ko03021 Bacteria COG1595@1,COG1595@2 NA|NA|NA K DNA-templated transcription, initiation MAG.T1.5_02237 330214.NIDE2185 1.2e-47 197.2 Bacteria ko:K07165 ko00000 Bacteria COG3712@1,COG3712@2 NA|NA|NA PT iron ion homeostasis MAG.T1.5_02238 330214.NIDE2183 7.4e-155 554.7 Bacteria ko:K02014 ko00000,ko02000 1.B.14 Bacteria COG4774@1,COG4774@2 NA|NA|NA P siderophore transport MAG.T1.5_02244 671143.DAMO_0789 5.5e-41 173.7 unclassified Bacteria Bacteria 2NRIX@2323,COG3744@1,COG3744@2 NA|NA|NA S PIN domain MAG.T1.5_02245 870187.Thini_3576 7.8e-20 102.8 Bacteria 3.1.3.5 ko:K01081 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 Bacteria COG4118@1,COG4118@2 NA|NA|NA D positive regulation of growth MAG.T1.5_02246 640081.Dsui_2974 2.6e-129 468.8 Rhodocyclales Bacteria 1MXGY@1224,2KWIX@206389,2VKZZ@28216,COG3182@1,COG3182@2 NA|NA|NA S PepSY-associated TM region MAG.T1.5_02247 322710.Avin_03870 1.3e-21 109.8 Gammaproteobacteria fecI12 5.2.1.8 ko:K03088,ko:K03769 ko00000,ko01000,ko03021,ko03110 Bacteria 1N1F5@1224,1SAR2@1236,COG1595@1,COG1595@2 NA|NA|NA K Belongs to the sigma-70 factor family. ECF subfamily MAG.T1.5_02248 330214.NIDE3525 3.6e-52 212.2 Bacteria ko:K07165 ko00000 Bacteria COG3712@1,COG3712@2 NA|NA|NA PT iron ion homeostasis MAG.T1.5_02249 330214.NIDE2183 3.2e-59 235.3 Bacteria ko:K02014 ko00000,ko02000 1.B.14 Bacteria COG4774@1,COG4774@2 NA|NA|NA P siderophore transport MAG.T1.5_02250 330214.NIDE2183 8.9e-197 693.3 Bacteria ko:K02014 ko00000,ko02000 1.B.14 Bacteria COG4774@1,COG4774@2 NA|NA|NA P siderophore transport MAG.T1.5_02252 351160.RCIX1144 2e-61 242.3 Euryarchaeota 1.11.1.15 ko:K03386 ko04214,map04214 ko00000,ko00001,ko01000,ko04147 Archaea 2XYCY@28890,COG0450@1,arCOG00312@2157 NA|NA|NA O AhpC/TSA family MAG.T1.5_02253 404589.Anae109_2801 2.6e-25 121.7 Deltaproteobacteria doc ko:K07341 ko00000,ko02048 Bacteria 1N1FW@1224,2WR7E@28221,42V74@68525,COG3654@1,COG3654@2 NA|NA|NA S Fic/DOC family MAG.T1.5_02254 517417.Cpar_1703 3.1e-12 77.4 Bacteria ko:K07172,ko:K18842 ko00000,ko02048 Bacteria COG2336@1,COG2336@2 NA|NA|NA T PFAM SpoVT AbrB MAG.T1.5_02255 330214.NIDE2170 1.8e-63 248.4 Bacteria yrkC Bacteria COG0662@1,COG0662@2 NA|NA|NA G Cupin 2, conserved barrel domain protein MAG.T1.5_02256 518766.Rmar_0400 3.6e-81 308.9 Bacteroidetes Order II. Incertae sedis enpP 3.1.3.1 ko:K01113 ko00790,ko01100,ko02020,map00790,map01100,map02020 M00126 R04620 RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 1FJY0@1100069,4NFFG@976,COG1524@1,COG1524@2 NA|NA|NA S Type I phosphodiesterase / nucleotide pyrophosphatase MAG.T1.5_02257 330214.NIDE2169 4.7e-304 1050.0 Bacteria Bacteria COG1506@1,COG1506@2 NA|NA|NA E serine-type peptidase activity MAG.T1.5_02259 330214.NIDE2168 1.5e-60 238.8 Bacteria exbB GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0017038,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 ko:K03561,ko:K03562 ko01120,map01120 ko00000,ko02000 1.A.30.2.1,1.A.30.2.2 Bacteria COG0811@1,COG0811@2 NA|NA|NA U bacteriocin transport MAG.T1.5_02260 330214.NIDE2167 2.1e-53 214.9 Bacteria exbD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03559 ko00000,ko02000 1.A.30.2.1 Bacteria COG0848@1,COG0848@2 NA|NA|NA U biopolymer transport protein MAG.T1.5_02261 330214.NIDE2166 9.2e-75 287.3 Bacteria ko:K03832 ko00000,ko02000 2.C.1.1 Bacteria COG0810@1,COG0810@2 NA|NA|NA M energy transducer activity MAG.T1.5_02263 330214.NIDE2164 6.7e-161 573.5 Bacteria mdtA_2 ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 Bacteria COG0845@1,COG0845@2 NA|NA|NA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family MAG.T1.5_02264 330214.NIDE2163 0.0 1638.2 Bacteria ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 Bacteria COG0841@1,COG0841@2 NA|NA|NA V transmembrane transporter activity MAG.T1.5_02265 1190606.AJYG01000173_gene520 8.3e-33 147.1 Vibrionales cpt ko:K18554 br01600,ko00000,ko01000,ko01504 Bacteria 1NEN0@1224,1STA5@1236,1XXNZ@135623,COG3896@1,COG3896@2 NA|NA|NA V Chloramphenicol phosphotransferase-like protein MAG.T1.5_02266 118163.Ple7327_2770 2e-19 101.7 Cyanobacteria Bacteria 1G620@1117,COG5485@1,COG5485@2 NA|NA|NA S PFAM SnoaL-like polyketide cyclase MAG.T1.5_02267 330214.NIDE2162 0.0 3211.0 Bacteria pvdI Bacteria COG1020@1,COG1020@2 NA|NA|NA Q D-alanine [D-alanyl carrier protein] ligase activity MAG.T1.5_02268 330214.NIDE2161 0.0 4688.6 Bacteria Bacteria COG1020@1,COG1020@2,COG2175@1,COG2175@2 NA|NA|NA Q oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors MAG.T1.5_02269 330214.NIDE2160 0.0 4176.7 Bacteria papA3 GO:0003674,GO:0003824,GO:0005975,GO:0005984,GO:0005991,GO:0006082,GO:0006629,GO:0006643,GO:0006664,GO:0006790,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009311,GO:0009987,GO:0016409,GO:0016740,GO:0016746,GO:0016747,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044262,GO:0044272,GO:0044281,GO:0046467,GO:0046505,GO:0046506,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 ko:K21183 M00827,M00828,M00832 ko00000,ko00001,ko00002 Bacteria COG1020@1,COG1020@2 NA|NA|NA Q D-alanine [D-alanyl carrier protein] ligase activity MAG.T1.5_02270 330214.NIDE2159 0.0 3256.1 Bacteria papA3 GO:0003674,GO:0003824,GO:0005975,GO:0005984,GO:0005991,GO:0006082,GO:0006629,GO:0006643,GO:0006664,GO:0006790,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009311,GO:0009987,GO:0016409,GO:0016740,GO:0016746,GO:0016747,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044262,GO:0044272,GO:0044281,GO:0046467,GO:0046505,GO:0046506,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 ko:K21183 M00827,M00828,M00832 ko00000,ko00001,ko00002 Bacteria COG1020@1,COG1020@2 NA|NA|NA Q D-alanine [D-alanyl carrier protein] ligase activity MAG.T1.5_02271 330214.NIDE2158 1.4e-160 572.4 Bacteria Bacteria COG2175@1,COG2175@2 NA|NA|NA Q oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors MAG.T1.5_02272 330214.NIDE2157 1.9e-106 392.1 Bacteria Bacteria COG3208@1,COG3208@2 NA|NA|NA Q Thioesterase involved in non-ribosomal peptide biosynthesis MAG.T1.5_02273 330214.NIDE2156 6.6e-35 152.9 Bacteria ko:K05375,ko:K09190 ko00261,ko01130,map00261,map01130 M00736 R10880 RC00064,RC00141,RC03296,RC03297,RC03298 ko00000,ko00001,ko00002 Bacteria COG3251@1,COG3251@2 NA|NA|NA P PFAM MbtH domain protein MAG.T1.5_02274 330214.NIDE2155 0.0 1151.0 Bacteria 3.5.1.11 ko:K01434 ko00311,ko01130,map00311,map01130 R02170 RC00166,RC00328 ko00000,ko00001,ko01000,ko01002 Bacteria COG2366@1,COG2366@2 NA|NA|NA D antibiotic biosynthetic process MAG.T1.5_02275 330214.NIDE2154 2.2e-241 841.3 Bacteria rhbA 2.6.1.76 ko:K00836 ko00260,ko01100,ko01120,ko01210,ko01230,map00260,map01100,map01120,map01210,map01230 M00033 R06977 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria COG0160@1,COG0160@2 NA|NA|NA E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family MAG.T1.5_02276 330214.NIDE2153 3.4e-252 877.5 Bacteria ko:K06160 ko02010,map02010 ko00000,ko00001,ko02000 3.A.1.113.2 Bacteria COG4615@1,COG4615@2 NA|NA|NA V microcin transport MAG.T1.5_02277 330214.NIDE2152 0.0 2009.2 Bacteria Bacteria COG1028@1,COG1028@2,COG3321@1,COG3321@2 NA|NA|NA Q synthase MAG.T1.5_02278 330214.NIDE2151 1.3e-66 259.6 Bacteria Bacteria COG1020@1,COG1020@2 NA|NA|NA Q D-alanine [D-alanyl carrier protein] ligase activity MAG.T1.5_02279 330214.NIDE2150 0.0 2612.4 Bacteria Bacteria COG0318@1,COG0318@2,COG1020@1,COG1020@2,COG4122@1,COG4122@2 NA|NA|NA E O-methyltransferase activity MAG.T1.5_02281 330214.NIDE2208 5.6e-207 726.9 Bacteria ko:K03301 ko00000 2.A.12 Bacteria COG3202@1,COG3202@2 NA|NA|NA C ATP:ADP antiporter activity MAG.T1.5_02282 330214.NIDE2207 1.8e-155 555.4 Bacteria ltaA 4.1.2.48 ko:K01620 ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 R00751,R06171 RC00312,RC00372 ko00000,ko00001,ko01000 Bacteria COG2008@1,COG2008@2 NA|NA|NA E L-allo-threonine aldolase activity MAG.T1.5_02284 330214.NIDE2205 1.8e-131 475.3 Bacteria ko:K17882 ko00000,ko01000,ko01504 Bacteria COG1708@1,COG1708@2 NA|NA|NA S nucleotidyltransferase activity MAG.T1.5_02285 330214.NIDE2204 2.6e-158 564.7 Bacteria gnd 1.1.1.343,1.1.1.44 ko:K00033 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200 M00004,M00006 R01528,R10221 RC00001,RC00539 ko00000,ko00001,ko00002,ko01000 Bacteria COG1023@1,COG1023@2 NA|NA|NA G D-gluconate metabolic process MAG.T1.5_02286 330214.NIDE2203 8.1e-272 942.6 Nitrospirae zwf GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 3J0XD@40117,COG0364@1,COG0364@2 NA|NA|NA G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone MAG.T1.5_02287 330214.NIDE2202 2.9e-40 171.0 Bacteria 1.8.1.9 ko:K00384,ko:K03671 ko00450,ko04621,ko05418,map00450,map04621,map05418 R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000,ko03110 Bacteria COG3118@1,COG3118@2 NA|NA|NA O belongs to the thioredoxin family MAG.T1.5_02288 330214.NIDE2201 2.8e-85 321.6 Bacteria Bacteria COG2755@1,COG2755@2 NA|NA|NA E lipolytic protein G-D-S-L family MAG.T1.5_02289 330214.NIDE2200 3.6e-271 940.6 Bacteria Bacteria COG1413@1,COG1413@2 NA|NA|NA C deoxyhypusine monooxygenase activity MAG.T1.5_02290 330214.NIDE2199 2.3e-258 897.9 Nitrospirae Bacteria 3J14V@40117,COG2206@1,COG2206@2 NA|NA|NA T Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_02292 330214.NIDE2197 8.2e-62 243.4 Nitrospirae ompH ko:K06142 ko00000 Bacteria 3J1AH@40117,COG2825@1,COG2825@2 NA|NA|NA M Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_02293 330214.NIDE2196 1.9e-163 582.0 Bacteria Bacteria COG2006@1,COG2006@2 NA|NA|NA U 4fe-4S ferredoxin, iron-sulfur binding domain protein MAG.T1.5_02294 330214.NIDE2195 1.7e-42 178.7 Bacteria Bacteria COG0607@1,COG0607@2 NA|NA|NA P Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS MAG.T1.5_02295 330214.NIDE2194 5.6e-157 560.5 Nitrospirae splB Bacteria 3J0QV@40117,COG1533@1,COG1533@2 NA|NA|NA L Elongator protein 3, MiaB family, Radical SAM MAG.T1.5_02296 330214.NIDE2193 1.2e-217 762.3 Nitrospirae serS GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004828,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006434,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009059,GO:0009069,GO:0009070,GO:0009987,GO:0010467,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iAF987.Gmet_3528,iSDY_1059.SDY_2368 Bacteria 3J0EP@40117,COG0172@1,COG0172@2 NA|NA|NA J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) MAG.T1.5_02306 644282.Deba_2236 1e-16 94.7 Deltaproteobacteria ko:K14059 ko00000 Bacteria 1MVZB@1224,2WRE7@28221,42W21@68525,COG0582@1,COG0582@2 NA|NA|NA L Belongs to the 'phage' integrase family MAG.T1.5_02308 1123261.AXDW01000010_gene360 2.2e-60 241.1 Xanthomonadales ko:K07265 ko00000 Bacteria 1QC30@1224,1T7R1@1236,1X9KH@135614,COG3562@1,COG3562@2 NA|NA|NA M Capsule polysaccharide biosynthesis protein MAG.T1.5_02309 261292.Nit79A3_1025 3.8e-12 77.4 Betaproteobacteria 3.2.1.132 ko:K01233 ko00520,ko01100,map00520,map01100 R02833 ko00000,ko00001,ko01000 Bacteria 1NEG1@1224,2VV5Y@28216,COG3409@1,COG3409@2 NA|NA|NA M Aids in the defense against invading fungal pathogens by degrading their cell wall chitosan MAG.T1.5_02310 1144275.COCOR_02847 7.6e-141 508.4 Deltaproteobacteria Bacteria 1QWMX@1224,2X73N@28221,43BSU@68525,COG5412@1,COG5412@2 NA|NA|NA C phage tail tape measure protein MAG.T1.5_02311 1144275.COCOR_02848 1.6e-174 619.8 Myxococcales hflB Bacteria 1NF48@1224,2WMCV@28221,2YXIN@29,43BJ4@68525,COG0464@1,COG0464@2 NA|NA|NA O ATPase family associated with various cellular activities (AAA) MAG.T1.5_02312 1144275.COCOR_02849 4.6e-72 279.3 Proteobacteria Bacteria 1QY06@1224,2DUXF@1,33SVE@2 NA|NA|NA MAG.T1.5_02313 1125863.JAFN01000001_gene2524 7.6e-27 127.9 Deltaproteobacteria lgt ko:K13292 ko00000,ko01000 Bacteria 1MVE3@1224,2WNPT@28221,42M2I@68525,COG0682@1,COG0682@2 NA|NA|NA M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins MAG.T1.5_02314 1123261.AXDW01000010_gene354 1.2e-49 204.9 Bacteria Bacteria 2C45E@1,34056@2 NA|NA|NA MAG.T1.5_02315 1429046.RR21198_0303 3.5e-13 83.2 Actinobacteria Bacteria 2ECCY@1,2H2Q3@201174,336B7@2 NA|NA|NA MAG.T1.5_02316 1144275.COCOR_02852 3.3e-82 312.4 Proteobacteria Bacteria 1RCEH@1224,2CH7C@1,32S5G@2 NA|NA|NA MAG.T1.5_02317 1144275.COCOR_02853 6.8e-76 291.6 Proteobacteria Bacteria 1N2J2@1224,2EC0B@1,335ZK@2 NA|NA|NA MAG.T1.5_02318 1144275.COCOR_02854 3.7e-193 682.2 Myxococcales Bacteria 1NEK3@1224,2WY5F@28221,2YW00@29,4327R@68525,COG4385@1,COG4385@2 NA|NA|NA S Phage tail protein (Tail_P2_I) MAG.T1.5_02319 1144275.COCOR_02855 1.6e-194 686.4 Myxococcales Bacteria 1MWKI@1224,2WM4B@28221,2YVXE@29,42Q9A@68525,COG3299@1,COG3299@2 NA|NA|NA S Baseplate J-like protein MAG.T1.5_02320 1144275.COCOR_02856 3.3e-33 147.9 Proteobacteria ko:K06903 ko00000 Bacteria 1NCAC@1224,COG3628@1,COG3628@2 NA|NA|NA S GPW gp25 family protein MAG.T1.5_02321 261292.Nit79A3_1012 1.9e-116 426.8 Proteobacteria Bacteria 1R3A3@1224,28NRK@1,332DP@2 NA|NA|NA MAG.T1.5_02322 84531.JMTZ01000038_gene3637 8.3e-83 313.5 Gammaproteobacteria Bacteria 1MU7Q@1224,1RZ3X@1236,COG3501@1,COG3501@2 NA|NA|NA S protein and some similarities with VgrG protein MAG.T1.5_02323 1144275.COCOR_02859 4.8e-103 381.3 Myxococcales ko:K06905 ko00000 Bacteria 1R67C@1224,2X3HN@28221,2YW57@29,4387V@68525,COG3500@1,COG3500@2 NA|NA|NA S Phage late control gene D protein (GPD) MAG.T1.5_02325 1144275.COCOR_02861 7.5e-52 210.7 Proteobacteria Bacteria 1NC3Q@1224,COG1652@1,COG1652@2 NA|NA|NA L Flagellar Assembly Protein A MAG.T1.5_02326 1123261.AXDW01000010_gene342 5.5e-51 207.2 Xanthomonadales Bacteria 1RM2J@1224,1T14R@1236,1XA9H@135614,2BEKE@1,328BU@2 NA|NA|NA S T4-like virus tail tube protein gp19 MAG.T1.5_02327 1144275.COCOR_02863 1.7e-137 497.3 Proteobacteria ko:K06907 ko00000 Bacteria 1NSAQ@1224,COG3497@1,COG3497@2 NA|NA|NA S Phage tail sheath protein subtilisin-like domain MAG.T1.5_02328 1123261.AXDW01000010_gene340 8.8e-43 179.9 Xanthomonadales Bacteria 1RKSC@1224,1T14S@1236,1X9RS@135614,2BECK@1,3283Q@2 NA|NA|NA S T4-like virus tail tube protein gp19 MAG.T1.5_02329 1123261.AXDW01000010_gene339 3.6e-200 704.9 Xanthomonadales ko:K06907 ko00000 Bacteria 1MX89@1224,1RQUU@1236,1X4D6@135614,COG3497@1,COG3497@2 NA|NA|NA S Phage tail sheath C-terminal domain MAG.T1.5_02330 1144275.COCOR_02866 2.9e-39 169.1 Proteobacteria Bacteria 1NVBE@1224,2C8HC@1,33V6K@2 NA|NA|NA MAG.T1.5_02331 1144275.COCOR_02867 3.8e-33 148.3 Proteobacteria Bacteria 1QVRN@1224,2CH4Q@1,338ZX@2 NA|NA|NA S Protein of unknown function (DUF4255) MAG.T1.5_02334 1184607.AUCHE_17_00260 1.5e-25 123.2 Dermatophilaceae ko:K02479 ko00000,ko02022 Bacteria 2IH77@201174,4F6IQ@85018,COG2197@1,COG2197@2 NA|NA|NA K helix_turn_helix, Lux Regulon MAG.T1.5_02337 404380.Gbem_0061 3.9e-52 211.8 Proteobacteria Bacteria 1RA9F@1224,2DMNF@1,32SNT@2 NA|NA|NA S FRG MAG.T1.5_02340 330214.NIDE1666 5e-229 800.0 Bacteria gpgS 2.4.1.266 ko:K13693 ko00000,ko01000,ko01003 GT81 Bacteria COG1215@1,COG1215@2 NA|NA|NA M transferase activity, transferring glycosyl groups MAG.T1.5_02343 330214.NIDE1669 1.4e-295 1021.5 Bacteria ipdC 4.1.1.74 ko:K04103 ko00380,ko01100,map00380,map01100 R01974 RC00506 ko00000,ko00001,ko01000 Bacteria COG3961@1,COG3961@2 NA|NA|NA GH pyruvate decarboxylase activity MAG.T1.5_02344 330214.NIDE1670 3.8e-197 694.1 Nitrospirae rlmI 2.1.1.191,2.1.1.72 ko:K00571,ko:K06969 ko00000,ko01000,ko02048,ko03009 Bacteria 3J0IV@40117,COG1092@1,COG1092@2 NA|NA|NA J S-adenosylmethionine-dependent methyltransferase MAG.T1.5_02345 330214.NIDE1671 1.1e-281 975.7 Bacteria oliA GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0051179,GO:0051234,GO:0055085 Bacteria COG1297@1,COG1297@2 NA|NA|NA S iron-nicotianamine transmembrane transporter activity MAG.T1.5_02346 330214.NIDE1672 1.7e-68 265.4 Bacteria Bacteria COG1396@1,COG1396@2 NA|NA|NA K sequence-specific DNA binding MAG.T1.5_02348 330214.NIDE1675 2.8e-103 381.7 Bacteria spoU 2.1.1.170,2.1.1.185 ko:K03218,ko:K03437,ko:K03501 ko00000,ko01000,ko03009,ko03016,ko03036 Bacteria COG0566@1,COG0566@2 NA|NA|NA J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family MAG.T1.5_02349 330214.NIDE1676 2.2e-238 831.2 Nitrospirae radA ko:K04485 ko00000,ko03400 Bacteria 3J0BP@40117,COG1066@1,COG1066@2 NA|NA|NA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function MAG.T1.5_02350 330214.NIDE1677 1.4e-126 459.1 Bacteria lolA Bacteria COG2834@1,COG2834@2 NA|NA|NA M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) MAG.T1.5_02351 330214.NIDE1678 1.1e-99 369.8 Nitrospirae yeaZ GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0071944,GO:0090304,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 ko:K01409,ko:K14742 R10648 RC00070,RC00416 ko00000,ko01000,ko03016 Bacteria 3J0VU@40117,COG1214@1,COG1214@2 NA|NA|NA O Glycoprotease family MAG.T1.5_02352 330214.NIDE1679 3.6e-69 267.7 Nitrospirae rimI 2.3.1.128 ko:K03789 ko00000,ko01000,ko03009 Bacteria 3J1CI@40117,COG0454@1,COG0456@2 NA|NA|NA K Acetyltransferase (GNAT) domain MAG.T1.5_02353 330214.NIDE1680 1.6e-26 124.8 Nitrospirae ko:K09794 ko00000 Bacteria 2DRP0@1,33CFM@2,3J1BN@40117 NA|NA|NA S Protein of unknown function (DUF465) MAG.T1.5_02354 330214.NIDE1681 1.3e-129 469.2 Nitrospirae tatC GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 ko:K03118 ko03060,ko03070,map03060,map03070 M00336 ko00000,ko00001,ko00002,ko02044 2.A.64 Bacteria 3J0PJ@40117,COG0805@1,COG0805@2 NA|NA|NA U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes MAG.T1.5_02355 330214.NIDE1682 1.4e-121 443.0 Bacteria Bacteria COG3292@1,COG3292@2 NA|NA|NA MAG.T1.5_02356 330214.NIDE1683 1.5e-86 325.5 Nitrospirae 5.2.1.8 ko:K03768 ko00000,ko01000,ko03110 Bacteria 3J18H@40117,COG0652@1,COG0652@2 NA|NA|NA O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides MAG.T1.5_02359 330214.NIDE1685 6.2e-231 806.6 Nitrospirae ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 Bacteria 3J140@40117,COG1538@1,COG1538@2 NA|NA|NA MU Outer membrane efflux protein MAG.T1.5_02360 330214.NIDE1686 2.3e-208 731.5 Nitrospirae Bacteria 3J13H@40117,COG0845@1,COG0845@2 NA|NA|NA M HlyD family secretion protein MAG.T1.5_02361 330214.NIDE1687 0.0 1939.9 Nitrospirae Bacteria 3J103@40117,COG0841@1,COG0841@2 NA|NA|NA V AcrB/AcrD/AcrF family MAG.T1.5_02362 330214.NIDE1688 6.5e-51 206.8 Bacteria kdpE ko:K03413 ko02020,ko02030,map02020,map02030 M00506 ko00000,ko00001,ko00002,ko02022,ko02035 Bacteria COG2197@1,COG2197@2 NA|NA|NA K response regulator MAG.T1.5_02363 330214.NIDE1690 5.3e-57 226.9 Bacteria Bacteria COG0840@1,COG0840@2 NA|NA|NA NT transmembrane signaling receptor activity MAG.T1.5_02364 330214.NIDE1691 5.4e-194 683.7 Nitrospirae Bacteria 3J0RT@40117,COG0477@1,COG2814@2 NA|NA|NA EGP Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_02365 330214.NIDE1692 5.1e-176 624.0 Bacteria Bacteria COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily MAG.T1.5_02366 439235.Dalk_0035 3.5e-40 171.8 Proteobacteria Bacteria 1NZ9S@1224,2F8C0@1,340R0@2 NA|NA|NA MAG.T1.5_02367 439235.Dalk_0034 9.7e-51 209.5 Proteobacteria Bacteria 1P0YF@1224,2FDDQ@1,345FE@2 NA|NA|NA MAG.T1.5_02368 261292.Nit79A3_2267 2.4e-59 235.7 Proteobacteria Bacteria 1NFMY@1224,2E84E@1,332I4@2 NA|NA|NA MAG.T1.5_02369 261292.Nit79A3_2268 1.5e-73 283.1 Proteobacteria Bacteria 1N9HN@1224,COG4782@1,COG4782@2 NA|NA|NA S Alpha/beta hydrolase of unknown function (DUF900) MAG.T1.5_02370 1288494.EBAPG3_19400 7.7e-60 237.7 Nitrosomonadales 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 Bacteria 1PSEB@1224,2VUDB@28216,373SI@32003,COG0412@1,COG0412@2 NA|NA|NA Q Dienelactone hydrolase MAG.T1.5_02371 517417.Cpar_1358 3.8e-91 342.8 Bacteria Bacteria 2E9D7@1,333KS@2 NA|NA|NA MAG.T1.5_02372 78245.Xaut_2906 7.9e-11 72.4 Xanthobacteraceae ko:K07483 ko00000 Bacteria 1PE1X@1224,2V5Q9@28211,3F23G@335928,COG2963@1,COG2963@2 NA|NA|NA L Transposase MAG.T1.5_02374 1173026.Glo7428_2080 8.4e-82 312.4 Cyanobacteria ko:K03406,ko:K21009 ko02020,ko02025,ko02030,map02020,map02025,map02030 ko00000,ko00001,ko02035 Bacteria 1G1Z5@1117,COG2202@1,COG2202@2,COG2203@1,COG2203@2,COG4251@1,COG4251@2,COG5278@1,COG5278@2 NA|NA|NA T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MAG.T1.5_02375 1305732.JAGG01000001_gene1613 1.4e-17 95.9 Bacteria Bacteria COG2197@1,COG2197@2 NA|NA|NA K response regulator MAG.T1.5_02376 330214.NIDE3182 1.3e-211 742.3 Nitrospirae pfp GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008443,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0046835,GO:0046872,GO:0047334,GO:0071704,GO:1901135 2.7.1.11,2.7.1.90 ko:K00850,ko:K00895,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 Bacteria 3J0Y1@40117,COG0205@1,COG0205@2 NA|NA|NA H Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions MAG.T1.5_02377 330214.NIDE3181 5.4e-130 470.7 Bacteria yihR GO:0003674,GO:0003824,GO:0004034,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005996,GO:0006006,GO:0006012,GO:0006082,GO:0006790,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016853,GO:0016854,GO:0016857,GO:0019318,GO:0019320,GO:0019388,GO:0033499,GO:0044237,GO:0044238,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046365,GO:0071704,GO:1901135,GO:1901136,GO:1901575,GO:1902776,GO:1902777 5.1.3.3 ko:K01785 ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130 M00632 R01602,R10619 RC00563 ko00000,ko00001,ko00002,ko01000 Bacteria COG2017@1,COG2017@2 NA|NA|NA G converts alpha-aldose to the beta-anomer MAG.T1.5_02378 1317124.DW2_05185 2.6e-08 67.4 Thioclava Bacteria 1MYB8@1224,2TQV5@28211,2XN1V@285107,COG0457@1,COG0457@2 NA|NA|NA S Tetratricopeptide repeat MAG.T1.5_02379 330214.NIDE3178 2.7e-235 821.2 Bacteria Bacteria COG0464@1,COG0464@2 NA|NA|NA O ATPase activity MAG.T1.5_02380 330214.NIDE3177 8.9e-124 449.9 Bacteria ko:K05516 ko00000,ko03036,ko03110 Bacteria COG0484@1,COG0484@2,COG1948@1,COG1948@2 NA|NA|NA L resolution of meiotic recombination intermediates MAG.T1.5_02381 330214.NIDE3176 2.6e-175 621.3 Nitrospirae galE 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0J5@40117,COG1087@1,COG1087@2 NA|NA|NA M Polysaccharide biosynthesis protein MAG.T1.5_02384 330214.NIDE3174 2.4e-61 242.3 Bacteria Bacteria 2E3YM@1,32YVJ@2 NA|NA|NA MAG.T1.5_02385 330214.NIDE3173 1.3e-145 522.7 Bacteria 3.2.1.52 ko:K12373 ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142 M00079 R00022,R06004,R11316 RC00049 ko00000,ko00001,ko00002,ko01000,ko03110 GH20 Bacteria COG3525@1,COG3525@2 NA|NA|NA G beta-N-acetylhexosaminidase activity MAG.T1.5_02386 330214.NIDE3170 2.6e-197 694.5 Nitrospirae ychF GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0043021,GO:0043022,GO:0043023,GO:0043086,GO:0044092,GO:0044424,GO:0044464,GO:0044877,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0098772 ko:K06942 ko00000,ko03009 Bacteria 3J0II@40117,COG0012@1,COG0012@2 NA|NA|NA J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner MAG.T1.5_02387 330214.NIDE3169 6.9e-75 286.6 Bacteria bfr GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008150,GO:0009987,GO:0019725,GO:0030003,GO:0042592,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0097577,GO:0098771 1.16.3.1 ko:K03594 ko00860,map00860 R00078 RC02758 ko00000,ko00001,ko01000 Bacteria COG2193@1,COG2193@2 NA|NA|NA P ferroxidase activity MAG.T1.5_02388 330214.NIDE3168 2.1e-71 275.0 Bacteria trmL GO:0001510,GO:0002128,GO:0002130,GO:0002131,GO:0002132,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.207 ko:K03216 ko00000,ko01000,ko03016 Bacteria COG0219@1,COG0219@2 NA|NA|NA J wobble position uridine ribose methylation MAG.T1.5_02389 330214.NIDE3165 0.0 1384.0 Bacteria yhgF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0044424,GO:0044444,GO:0044464,GO:0050896 ko:K06959 ko00000 Bacteria COG2183@1,COG2183@2 NA|NA|NA K obsolete transcription factor activity, core RNA polymerase II binding MAG.T1.5_02390 330214.NIDE3164 6.1e-76 290.4 Bacteria ko:K07006 ko00000 Bacteria COG3576@1,COG3576@2 NA|NA|NA S Pyridoxamine 5'-phosphate oxidase MAG.T1.5_02391 330214.NIDE3163 1.6e-204 718.8 Bacteria frgC ko:K07714 ko02020,map02020 M00500 ko00000,ko00001,ko00002,ko02022 Bacteria COG2204@1,COG2204@2 NA|NA|NA T phosphorelay signal transduction system MAG.T1.5_02392 330214.NIDE3162 1.6e-243 848.6 Bacteria ko:K14978 ko02020,map02020 M00663 ko00000,ko00001,ko00002,ko01001,ko02022 Bacteria COG3850@1,COG3850@2,COG4251@1,COG4251@2 NA|NA|NA T phosphorelay sensor kinase activity MAG.T1.5_02394 330214.NIDE3158 2.9e-108 398.3 Bacteria ko:K02020 ko02010,map02010 M00189 ko00000,ko00001,ko00002,ko02000 3.A.1.8 Bacteria COG0725@1,COG0725@2 NA|NA|NA P tungstate binding MAG.T1.5_02395 330214.NIDE3157 1.8e-266 924.9 Bacteria Bacteria COG3746@1,COG3746@2 NA|NA|NA MAG.T1.5_02396 330214.NIDE3156 8.3e-128 463.8 Nitrospirae Bacteria 3J13A@40117,COG1476@1,COG1476@2,COG1910@1,COG1910@2 NA|NA|NA K PBP superfamily domain MAG.T1.5_02397 330214.NIDE3155 6.1e-77 294.3 Bacteria ko:K02020 ko02010,map02010 M00189 ko00000,ko00001,ko00002,ko02000 3.A.1.8 Bacteria COG0725@1,COG0725@2 NA|NA|NA P tungstate binding MAG.T1.5_02399 330214.NIDE3153 5.9e-236 823.5 Bacteria Bacteria COG3746@1,COG3746@2 NA|NA|NA MAG.T1.5_02400 330214.NIDE3152 5.4e-109 400.6 Nitrospirae modA ko:K02020 ko02010,map02010 M00189 ko00000,ko00001,ko00002,ko02000 3.A.1.8 Bacteria 3J18Z@40117,COG0725@1,COG0725@2 NA|NA|NA P Bacterial extracellular solute-binding protein MAG.T1.5_02402 330214.NIDE3149 4.8e-109 400.6 Bacteria modB ko:K02018,ko:K15496 ko02010,map02010 M00189,M00423 ko00000,ko00001,ko00002,ko02000 3.A.1.6.5,3.A.1.8 Bacteria COG4149@1,COG4149@2 NA|NA|NA P molybdate abc transporter MAG.T1.5_02403 330214.NIDE3148 2.6e-160 571.6 Bacteria modC 2.10.1.1,3.6.3.29,3.6.3.55 ko:K02017,ko:K02018,ko:K03750,ko:K15497 ko00790,ko01100,ko02010,map00790,map01100,map02010 M00189,M00423 R09735,R10531 RC00002,RC03462 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.6.5,3.A.1.8 Bacteria COG3842@1,COG3842@2 NA|NA|NA P ATPase activity MAG.T1.5_02406 452637.Oter_0694 2.7e-205 721.5 Bacteria hss 2.5.1.44 ko:K00808 ko00960,ko01110,map00960,map01110 R00018 RC00053 ko00000,ko00001,ko01000 Bacteria COG5310@1,COG5310@2 NA|NA|NA Q Homospermidine synthase MAG.T1.5_02407 452637.Oter_0693 2.9e-146 525.0 Verrucomicrobia ldc 4.1.1.17 ko:K01581 ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130 M00134 R00670 RC00299 ko00000,ko00001,ko00002,ko01000 Bacteria 46WJD@74201,COG0019@1,COG0019@2 NA|NA|NA E PFAM Orn DAP Arg decarboxylase 2 MAG.T1.5_02408 330214.NIDE3144 1.3e-80 305.8 Nitrospirae lexA 3.4.21.88 ko:K01356 M00729 ko00000,ko00002,ko01000,ko01002,ko03400 Bacteria 3J1C0@40117,COG1974@1,COG1974@2 NA|NA|NA K Represses a number of genes involved in the response to DNA damage (SOS response) MAG.T1.5_02413 1191523.MROS_1245 3.2e-57 229.9 Bacteria Bacteria COG2202@1,COG2202@2,COG3290@1,COG3290@2,COG4585@1,COG4585@2 NA|NA|NA T protein histidine kinase activity MAG.T1.5_02414 768710.DesyoDRAFT_1526 3.1e-39 168.7 Clostridia ko:K02282 ko00000,ko02035,ko02044 Bacteria 1TSBV@1239,25BWE@186801,COG2197@1,COG2197@2 NA|NA|NA K PFAM Response regulator receiver domain MAG.T1.5_02416 330214.NIDE3134 7.6e-08 64.7 Nitrospirae Bacteria 3J1CG@40117,COG0457@1,COG0457@2 NA|NA|NA S Evidence 5 No homology to any previously reported sequences MAG.T1.5_02418 330214.NIDE3133 3.4e-122 444.5 Bacteria Bacteria 2C8FN@1,2ZBER@2 NA|NA|NA MAG.T1.5_02420 1382359.JIAL01000001_gene350 1.6e-83 316.6 Bacteria VVA0737 GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0031224,GO:0031226,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 ko:K06212,ko:K06402 ko00000,ko01000,ko01002,ko02000 1.A.16.1.1,1.A.16.1.3 Bacteria COG0517@1,COG0517@2,COG1994@1,COG1994@2 NA|NA|NA S metallopeptidase activity MAG.T1.5_02422 42256.RradSPS_0959 1.3e-137 496.5 Rubrobacteria zwf 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GISI@201174,4CPHW@84995,COG0364@1,COG0364@2 NA|NA|NA G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone MAG.T1.5_02423 713587.THITH_11275 2.2e-228 798.5 Gammaproteobacteria Bacteria 1MV08@1224,1RS4U@1236,COG3387@1,COG3387@2 NA|NA|NA G Glucoamylase and related glycosyl hydrolases MAG.T1.5_02424 215803.DB30_8587 4.2e-63 248.1 Myxococcales 3.5.1.9 ko:K07130 ko00380,ko00630,ko01100,map00380,map00630,map01100 M00038 R00988,R01959,R04911 RC00263,RC00323 ko00000,ko00001,ko00002,ko01000 Bacteria 1P8U5@1224,2WPQ7@28221,2YV2X@29,42SY1@68525,COG1878@1,COG1878@2 NA|NA|NA S Putative cyclase MAG.T1.5_02426 1366050.N234_11525 4.6e-148 532.3 Betaproteobacteria 1.9.3.1 ko:K00404 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 ko00000,ko00001,ko00002,ko01000 3.D.4.3 Bacteria 1MXBD@1224,2VHMB@28216,COG3278@1,COG3278@2 NA|NA|NA C Cytochrome c oxidase subunit MAG.T1.5_02428 575540.Isop_2988 6.2e-44 184.9 Bacteria Bacteria 2BQC7@1,32J7B@2 NA|NA|NA MAG.T1.5_02429 1121440.AUMA01000002_gene2071 1e-121 443.7 Desulfovibrionales nhaA ko:K03313 ko00000,ko02000 2.A.33.1 Bacteria 1MW15@1224,2M8S9@213115,2WINT@28221,42MBN@68525,COG3004@1,COG3004@2 NA|NA|NA P ) H( ) antiporter that extrudes sodium in exchange for external protons MAG.T1.5_02431 330214.NIDE3131 3.8e-136 491.1 Nitrospirae ko:K22044 ko00000,ko02000 1.A.23.3 Bacteria 3J0YK@40117,COG0668@1,COG0668@2 NA|NA|NA M Mechanosensitive ion channel MAG.T1.5_02432 330214.NIDE3129 6.2e-295 1019.6 Nitrospirae Bacteria 3J13U@40117,COG1960@1,COG1960@2 NA|NA|NA C Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_02433 330214.NIDE3128 1.7e-251 875.2 Bacteria 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 Bacteria COG0318@1,COG0318@2 NA|NA|NA IQ PFAM AMP-dependent synthetase and ligase MAG.T1.5_02434 330214.NIDE3127 2.7e-163 581.6 Bacteria prpC GO:0003674,GO:0003824,GO:0004108,GO:0006082,GO:0006091,GO:0006113,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016740,GO:0016746,GO:0016829,GO:0016830,GO:0016833,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0036440,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0046459,GO:0046912,GO:0050440,GO:0055114,GO:0071704 2.3.3.1,2.3.3.5 ko:K01647,ko:K01659 ko00020,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351,R00931 RC00004,RC00067,RC00406,RC02827 br01601,ko00000,ko00001,ko00002,ko01000 iECED1_1282.ECED1_0365,iECIAI1_1343.ECIAI1_0334,iECIAI39_1322.ECIAI39_0347,iECP_1309.ECP_0408,iECSF_1327.ECSF_0308,iEcE24377_1341.EcE24377A_0357,iJN746.PP_2335,iLF82_1304.LF82_1740,iNRG857_1313.NRG857_01630 Bacteria COG0372@1,COG0372@2 NA|NA|NA C Belongs to the citrate synthase family MAG.T1.5_02435 330214.NIDE3126 5.2e-106 391.0 Bacteria prpB GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006113,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0015980,GO:0016042,GO:0016054,GO:0016829,GO:0016830,GO:0016833,GO:0016999,GO:0017001,GO:0017144,GO:0019541,GO:0019543,GO:0019626,GO:0019629,GO:0019752,GO:0032787,GO:0042737,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0046421,GO:0046459,GO:0046872,GO:0055114,GO:0071704,GO:0072329,GO:1901575 4.1.3.30 ko:K03417 ko00640,map00640 R00409 RC00286,RC00287 ko00000,ko00001,ko01000 iECNA114_1301.ECNA114_0319,iECP_1309.ECP_0407 Bacteria COG2513@1,COG2513@2 NA|NA|NA G methylisocitrate lyase activity MAG.T1.5_02436 330214.NIDE3125 1.6e-183 649.0 Bacteria prpD GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009268,GO:0009628,GO:0009987,GO:0010447,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017001,GO:0017144,GO:0019541,GO:0019543,GO:0019626,GO:0019629,GO:0019679,GO:0019752,GO:0030312,GO:0032787,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046459,GO:0047547,GO:0050896,GO:0071704,GO:0071944,GO:0072329,GO:1901575 4.2.1.79 ko:K01720 ko00640,map00640 R04424 RC01152 ko00000,ko00001,ko01000 Bacteria COG2079@1,COG2079@2 NA|NA|NA S 2-methylcitrate dehydratase activity MAG.T1.5_02437 330214.NIDE3124 1.8e-83 315.8 Bacteria argK ko:K07588 ko00000,ko01000 Bacteria COG1703@1,COG1703@2 NA|NA|NA E isobutyryl-CoA mutase activity MAG.T1.5_02438 330214.NIDE3123 6.8e-125 453.8 Bacteria mvaB GO:0000287,GO:0003674,GO:0003824,GO:0004419,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005777,GO:0005782,GO:0005829,GO:0006082,GO:0006091,GO:0006520,GO:0006551,GO:0006552,GO:0006605,GO:0006625,GO:0006629,GO:0006807,GO:0006810,GO:0006886,GO:0006996,GO:0007031,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009063,GO:0009081,GO:0009083,GO:0009987,GO:0015031,GO:0015833,GO:0016043,GO:0016054,GO:0016829,GO:0016830,GO:0016833,GO:0017144,GO:0019752,GO:0022607,GO:0030145,GO:0031907,GO:0031974,GO:0033036,GO:0033365,GO:0034613,GO:0042579,GO:0042802,GO:0042803,GO:0042886,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043574,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0046395,GO:0046872,GO:0046907,GO:0046914,GO:0046950,GO:0046951,GO:0046983,GO:0051179,GO:0051234,GO:0051259,GO:0051262,GO:0051641,GO:0051649,GO:0065003,GO:0070013,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0072594,GO:0072662,GO:0072663,GO:1901564,GO:1901565,GO:1901568,GO:1901570,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1902224 4.1.3.4,6.4.1.4 ko:K01640,ko:K01968 ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146 M00036,M00088 R01360,R04138,R08090 RC00367,RC00502,RC00503,RC00942,RC01118,RC01946 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_3293 Bacteria COG0119@1,COG0119@2 NA|NA|NA E Belongs to the alpha-IPM synthase homocitrate synthase family MAG.T1.5_02439 330214.NIDE3122 2.3e-84 318.9 Bacteria atuE 4.2.1.18,4.2.1.57 ko:K13766,ko:K13779 ko00280,ko00281,ko01100,map00280,map00281,map01100 M00036 R02085,R03493 RC00941,RC02416 ko00000,ko00001,ko00002,ko01000 Bacteria COG1024@1,COG1024@2 NA|NA|NA I Enoyl-CoA hydratase MAG.T1.5_02440 330214.NIDE3121 9.3e-260 902.5 Bacteria mccB 2.1.3.15,6.4.1.3,6.4.1.4,6.4.1.5 ko:K01969,ko:K13778,ko:K15052 ko00280,ko00281,ko00720,ko01100,ko01200,map00280,map00281,map00720,map01100,map01200 M00036,M00376 R01859,R03494,R04138 RC00097,RC00367,RC00609,RC00942 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_3290 Bacteria COG4799@1,COG4799@2 NA|NA|NA I CoA carboxylase activity MAG.T1.5_02441 330214.NIDE3120 6e-62 243.4 Bacteria 5.4.99.2 ko:K01849 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 Bacteria COG2185@1,COG2185@2 NA|NA|NA I cobalamin binding MAG.T1.5_02442 330214.NIDE3119 1.5e-128 465.7 Nitrospirae ytnP Bacteria 3J1C9@40117,COG0491@1,COG0491@2 NA|NA|NA S Metallo-beta-lactamase superfamily MAG.T1.5_02443 330214.NIDE3118 1.7e-269 934.9 Bacteria icmA 5.4.99.2 ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 Bacteria COG1884@1,COG1884@2 NA|NA|NA I Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly MAG.T1.5_02444 330214.NIDE3117 3e-143 514.6 Bacteria mmgB 1.1.1.157,1.1.1.35,4.2.1.17,5.1.2.3 ko:K00074,ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R01976,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R05576,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 Bacteria COG1250@1,COG1250@2 NA|NA|NA I 3-hydroxyacyl-CoA dehydrogenase MAG.T1.5_02445 330214.NIDE3116 3.2e-180 637.9 Bacteria atoB 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 iJN746.PP_2215 Bacteria COG0183@1,COG0183@2 NA|NA|NA I Belongs to the thiolase family MAG.T1.5_02446 330214.NIDE3115 3.7e-149 534.6 Bacteria bfmBB 2.3.1.168,2.3.1.61 ko:K00658,ko:K09699 ko00020,ko00280,ko00310,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00280,map00310,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032,M00036 R02570,R02571,R02662,R03174,R04097,R08549,R10998 RC00004,RC02727,RC02833,RC02870 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria COG0508@1,COG0508@2 NA|NA|NA C S-acyltransferase activity MAG.T1.5_02447 330214.NIDE3114 8e-177 626.3 Bacteria bfmBA 1.2.4.4 ko:K00167,ko:K11381,ko:K21417 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00027,RC00627,RC02743,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria COG0022@1,COG0022@2 NA|NA|NA C oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor MAG.T1.5_02448 330214.NIDE3113 8.6e-163 579.7 Bacteria bfmBA 1.2.4.1,1.2.4.4 ko:K00161,ko:K11381,ko:K21416 ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00036,M00307 R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria COG1071@1,COG1071@2 NA|NA|NA C oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor MAG.T1.5_02449 330214.NIDE3112 6.1e-108 397.1 Bacteria pyrE 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 Bacteria COG0461@1,COG0461@2 NA|NA|NA F orotate phosphoribosyltransferase activity MAG.T1.5_02450 330214.NIDE3111 9.9e-151 539.7 Nitrospirae Bacteria 3J1AP@40117,COG0179@1,COG0179@2 NA|NA|NA Q Fumarylacetoacetate (FAA) hydrolase family MAG.T1.5_02451 330214.NIDE3110 2.4e-174 618.2 Bacteria hmgA GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114 1.13.11.5 ko:K00451 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R02519 RC00737 ko00000,ko00001,ko00002,ko01000 Bacteria COG3508@1,COG3508@2 NA|NA|NA Q Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate MAG.T1.5_02452 330214.NIDE3109 1.1e-93 349.4 Bacteria 5.1.99.1 ko:K05606,ko:K17315 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,ko02010,map00280,map00630,map00640,map00720,map01100,map01120,map01200,map02010 M00373,M00375,M00376,M00605,M00741 R02765,R09979 RC00780,RC02739 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.1.24,3.A.1.1.30 Bacteria COG3185@1,COG3185@2 NA|NA|NA E 4-Hydroxyphenylpyruvate dioxygenase MAG.T1.5_02453 330214.NIDE3106 1.9e-98 365.5 Bacteria 1.3.3.11 ko:K06137 ko00000,ko01000 Bacteria COG5424@1,COG5424@2 NA|NA|NA H Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ MAG.T1.5_02454 330214.NIDE3105 1.4e-261 908.7 Nitrospirae 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 Bacteria 3J12Y@40117,COG0318@1,COG0318@2 NA|NA|NA IQ AMP-binding enzyme C-terminal domain MAG.T1.5_02455 330214.NIDE3104 3.9e-194 684.1 Bacteria thlA 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria COG0183@1,COG0183@2 NA|NA|NA I Belongs to the thiolase family MAG.T1.5_02456 330214.NIDE3103 7e-183 646.7 Nitrospirae fadB GO:0003674,GO:0003824,GO:0003857,GO:0004165,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0008692,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016856,GO:0016860,GO:0016863,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 1.1.1.157,1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8 ko:K00074,ko:K01782,ko:K01825 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R01976,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R04756,R05066,R05305,R05576,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01078,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 iECABU_c1320.ECABU_c26730,iETEC_1333.ETEC_2476,iEcE24377_1341.EcE24377A_2637,iLF82_1304.LF82_0614,iNRG857_1313.NRG857_19200,ic_1306.c2886 Bacteria 3J1F9@40117,COG1250@1,COG1250@2 NA|NA|NA C 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain MAG.T1.5_02458 330214.NIDE3102 1.1e-109 402.9 Nitrospirae fadB GO:0003674,GO:0003824,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 4.2.1.17 ko:K01715,ko:K13767 ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212 M00087 R03026,R04170,R04738,R04740,R04744,R04746 RC00831,RC01095 ko00000,ko00001,ko00002,ko01000 Bacteria 3J1EP@40117,COG1024@1,COG1024@2 NA|NA|NA I Enoyl-CoA hydratase/isomerase MAG.T1.5_02459 330214.NIDE3101 3.7e-176 624.4 Bacteria ko:K07001 ko00000 Bacteria COG1752@1,COG1752@2 NA|NA|NA M Esterase of the alpha-beta hydrolase superfamily MAG.T1.5_02460 330214.NIDE3100 4.3e-251 874.0 Nitrospirae fadE10 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 Bacteria 3J13U@40117,COG1960@1,COG1960@2 NA|NA|NA C Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_02461 330214.NIDE3099 7e-163 580.1 Bacteria Bacteria 2DQ6K@1,334ZA@2 NA|NA|NA MAG.T1.5_02462 880073.Calab_3483 2.1e-14 84.3 unclassified Bacteria tnaA 4.1.99.1 ko:K01667 ko00380,map00380 R00673 RC00209,RC00355 ko00000,ko00001,ko01000 Bacteria 2NNZV@2323,COG3033@1,COG3033@2 NA|NA|NA E Beta-eliminating lyase MAG.T1.5_02463 869210.Marky_1642 1.4e-21 108.6 Deinococcus-Thermus tnaA 4.1.99.1 ko:K01667 ko00380,map00380 R00673 RC00209,RC00355 ko00000,ko00001,ko01000 Bacteria 1WM62@1297,COG3033@1,COG3033@2 NA|NA|NA E PFAM aromatic amino acid beta-eliminating lyase threonine aldolase MAG.T1.5_02464 880073.Calab_3483 2.9e-40 171.4 unclassified Bacteria tnaA 4.1.99.1 ko:K01667 ko00380,map00380 R00673 RC00209,RC00355 ko00000,ko00001,ko01000 Bacteria 2NNZV@2323,COG3033@1,COG3033@2 NA|NA|NA E Beta-eliminating lyase MAG.T1.5_02465 880073.Calab_3483 2e-21 108.6 unclassified Bacteria tnaA 4.1.99.1 ko:K01667 ko00380,map00380 R00673 RC00209,RC00355 ko00000,ko00001,ko01000 Bacteria 2NNZV@2323,COG3033@1,COG3033@2 NA|NA|NA E Beta-eliminating lyase MAG.T1.5_02466 1191523.MROS_0698 2e-08 64.7 Bacteria tnaA 4.1.99.1 ko:K01667 ko00380,map00380 R00673 RC00209,RC00355 ko00000,ko00001,ko01000 Bacteria COG3033@1,COG3033@2 NA|NA|NA E tryptophanase activity MAG.T1.5_02467 330214.NIDE3098 7.3e-293 1012.7 Bacteria Bacteria COG2831@1,COG2831@2 NA|NA|NA U hemolysin activation secretion protein MAG.T1.5_02468 330214.NIDE3097 3.5e-193 681.0 Bacteria Bacteria COG3210@1,COG3210@2 NA|NA|NA U domain, Protein MAG.T1.5_02469 330214.NIDE3096 0.0 1163.3 Bacteria Bacteria COG0457@1,COG0457@2,COG4995@1,COG4995@2 NA|NA|NA S CHAT domain MAG.T1.5_02470 330214.NIDE3095 1.8e-90 339.0 Bacteria Bacteria COG1750@1,COG1750@2 NA|NA|NA MAG.T1.5_02471 330214.NIDE3094 2.2e-114 418.7 Bacteria Bacteria COG4221@1,COG4221@2 NA|NA|NA IQ oxidoreductase activity MAG.T1.5_02472 330214.NIDE3093 5.9e-62 243.4 Nitrospirae Bacteria 3J1FA@40117,COG1051@1,COG1051@2 NA|NA|NA F Belongs to the Nudix hydrolase family MAG.T1.5_02473 330214.NIDE3092 0.0 1718.4 Nitrospirae 2.7.13.3 ko:K07675 ko02020,map02020 M00473 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 3J12P@40117,COG2202@1,COG2202@2,COG3829@1,COG3829@2,COG4585@1,COG4585@2 NA|NA|NA T Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_02474 330214.NIDE3091 1.4e-110 405.6 Nitrospirae vsrD2 ko:K02282,ko:K07689 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 M00475 ko00000,ko00001,ko00002,ko02022,ko02035,ko02044 Bacteria 3J12Q@40117,COG2197@1,COG2197@2 NA|NA|NA K Product type r regulator MAG.T1.5_02477 330214.NIDE3088 5.8e-197 693.7 Nitrospirae atoC ko:K02481 ko00000,ko02022 Bacteria 3J107@40117,COG2204@1,COG2204@2 NA|NA|NA T Bacterial regulatory protein, Fis family MAG.T1.5_02478 330214.NIDE3087 7.7e-84 316.6 Bacteria ycbK ko:K02395 ko00000,ko02035 Bacteria COG3108@1,COG3108@2 NA|NA|NA S Peptidase M15 MAG.T1.5_02483 330214.NIDE3081 4.7e-131 473.8 Bacteria Bacteria COG3253@1,COG3253@2 NA|NA|NA S peroxidase activity MAG.T1.5_02485 330214.NIDE3079 1.1e-191 676.0 Nitrospirae cinA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0019159,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363 3.5.1.42 ko:K03742,ko:K03743 ko00760,map00760 R02322 RC00100 ko00000,ko00001,ko01000 Bacteria 3J1AS@40117,COG1058@1,COG1058@2,COG1546@1,COG1546@2 NA|NA|NA S Competence-damaged protein MAG.T1.5_02486 330214.NIDE3078 3.5e-66 258.1 Nitrospirae ligT GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008104,GO:0008150,GO:0009966,GO:0010646,GO:0010738,GO:0023051,GO:0033036,GO:0034237,GO:0044424,GO:0044444,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051018,GO:0051179,GO:0065007,GO:1902531 3.1.4.58 ko:K01975 ko00000,ko01000,ko03016 Bacteria 3J1B8@40117,COG1514@1,COG1514@2 NA|NA|NA J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester MAG.T1.5_02488 330214.NIDE1705 2.4e-190 671.4 Nitrospirae recA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360 ko:K03553 ko03440,map03440 M00729 ko00000,ko00001,ko00002,ko03400 Bacteria 3J0C1@40117,COG0468@1,COG0468@2 NA|NA|NA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage MAG.T1.5_02489 330214.NIDE1706 5.7e-55 220.3 Bacteria recX GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0019899,GO:0031668,GO:0033554,GO:0043086,GO:0044092,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496 2.4.1.337 ko:K03565,ko:K19002 ko00561,ko01100,map00561,map01100 R10850 RC00005,RC00059 ko00000,ko00001,ko01000,ko01003,ko03400 GT4 Bacteria COG2137@1,COG2137@2 NA|NA|NA S regulation of DNA repair MAG.T1.5_02490 330214.NIDE1707 0.0 1637.9 Nitrospirae alaS GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002161,GO:0002196,GO:0003674,GO:0003700,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006355,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009451,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:0140110,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iECABU_c1320.ECABU_c29670,iECED1_1282.ECED1_3146,iEcHS_1320.EcHS_A2833,iJN746.PP_4474 Bacteria 3J0D3@40117,COG0013@1,COG0013@2 NA|NA|NA J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain MAG.T1.5_02491 330214.NIDE1708 1.4e-83 315.8 Nitrospirae yqgF GO:0000966,GO:0000967,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0140097,GO:1901360 ko:K07447 ko00000,ko01000 Bacteria 3J1AR@40117,COG0816@1,COG0816@2 NA|NA|NA L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA MAG.T1.5_02492 330214.NIDE1709 1.5e-156 558.9 Nitrospirae mltG ko:K07082 ko00000 Bacteria 3J0IR@40117,COG1559@1,COG1559@2 NA|NA|NA S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation MAG.T1.5_02493 330214.NIDE1710 6.7e-106 390.2 Bacteria deoC 4.1.2.4 ko:K01619 ko00030,map00030 R01066 RC00436,RC00437 ko00000,ko00001,ko01000 Bacteria COG0274@1,COG0274@2 NA|NA|NA F deoxyribose-phosphate aldolase activity MAG.T1.5_02494 330214.NIDE1711 9.6e-190 669.5 Bacteria deoB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008973,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 5.4.2.7 ko:K01839 ko00030,ko00230,map00030,map00230 R01057,R02749 RC00408 ko00000,ko00001,ko01000 iLF82_1304.LF82_0465,iNRG857_1313.NRG857_22165 Bacteria COG1015@1,COG1015@2 NA|NA|NA G phosphopentomutase activity MAG.T1.5_02496 330214.NIDE1721 4.8e-22 110.5 Bacteria Bacteria 2EU10@1,33MI2@2 NA|NA|NA MAG.T1.5_02499 330214.NIDE1723 1.8e-70 271.9 Nitrospirae Bacteria 3J144@40117,COG0251@1,COG0251@2 NA|NA|NA J Endoribonuclease L-PSP MAG.T1.5_02500 330214.NIDE1724 1.8e-301 1041.2 Bacteria Bacteria COG5184@1,COG5184@2 NA|NA|NA DZ guanyl-nucleotide exchange factor activity MAG.T1.5_02501 330214.NIDE1725 2.8e-25 122.9 Nitrospirae Bacteria 3J16A@40117,COG4447@1,COG4447@2 NA|NA|NA S Photosynthesis system II assembly factor YCF48 MAG.T1.5_02502 330214.NIDE1726 9.9e-61 239.6 Nitrospirae rsmE 2.1.1.193 ko:K09761 ko00000,ko01000,ko03009 Bacteria 3J18K@40117,COG1385@1,COG1385@2 NA|NA|NA J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit MAG.T1.5_02504 330214.NIDE1727 1.1e-195 689.1 Nitrospirae dnaJ GO:0000988,GO:0000989,GO:0003674,GO:0003756,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006457,GO:0006458,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010556,GO:0015035,GO:0015036,GO:0016020,GO:0016032,GO:0016043,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0016989,GO:0019219,GO:0019222,GO:0022607,GO:0031323,GO:0031326,GO:0032991,GO:0034641,GO:0034645,GO:0042026,GO:0043167,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051704,GO:0055114,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0140096,GO:0140110,GO:1901360,GO:1901576,GO:1903506,GO:2001141 ko:K03686 ko00000,ko03029,ko03110 Bacteria 3J0A7@40117,COG0484@1,COG0484@2 NA|NA|NA O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins MAG.T1.5_02505 330214.NIDE1728 0.0 1126.7 Nitrospirae dnaK GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0018995,GO:0019219,GO:0019222,GO:0020003,GO:0022607,GO:0030430,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0033643,GO:0033646,GO:0033655,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043531,GO:0043656,GO:0043657,GO:0043933,GO:0044085,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0065010,GO:0070887,GO:0071310,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 Bacteria 3J0D2@40117,COG0443@1,COG0443@2 NA|NA|NA O Heat shock 70 kDa protein MAG.T1.5_02506 330214.NIDE1729 3.1e-69 268.1 Nitrospirae grpE GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0017076,GO:0030234,GO:0030312,GO:0030554,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036094,GO:0040007,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0050896,GO:0051082,GO:0051716,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0071496,GO:0071944,GO:0097159,GO:0098772,GO:1901265,GO:1901363 ko:K03687 ko00000,ko03029,ko03110 Bacteria 3J0QP@40117,COG0576@1,COG0576@2 NA|NA|NA O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ MAG.T1.5_02507 330214.NIDE1730 4.5e-127 460.7 Nitrospirae coaX GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1986 Bacteria 3J0TR@40117,COG1521@1,COG1521@2 NA|NA|NA H Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis MAG.T1.5_02508 330214.NIDE1731 5.7e-110 404.1 Nitrospirae birA GO:0000166,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004077,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009305,GO:0009374,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0017053,GO:0017076,GO:0017144,GO:0018130,GO:0018271,GO:0019538,GO:0019752,GO:0019842,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032991,GO:0033218,GO:0033293,GO:0034641,GO:0035639,GO:0036094,GO:0036211,GO:0042364,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043565,GO:0043603,GO:0043604,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1990837 2.7.1.33,6.3.4.15 ko:K01947,ko:K03524 ko00770,ko00780,ko01100,map00770,map00780,map01100 M00120 R01074,R02971,R03018,R04391,R05145 RC00002,RC00017,RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko00002,ko01000,ko03000 Bacteria 3J0U2@40117,COG0340@1,COG0340@2 NA|NA|NA H Biotin/lipoate A/B protein ligase family MAG.T1.5_02509 330214.NIDE1732 7.3e-121 440.3 Nitrospirae modD 2.4.2.19 ko:K00767,ko:K03813 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0JY@40117,COG0157@1,COG0157@2 NA|NA|NA H Quinolinate phosphoribosyl transferase, C-terminal domain MAG.T1.5_02510 330214.NIDE1733 0.0 1624.8 Nitrospirae valS GO:0000287,GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006438,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045903,GO:0046483,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0061475,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:2000112 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iECH74115_1262.ECH74115_5779,iECNA114_1301.ECNA114_4481,iECO26_1355.ECO26_5428,iECSP_1301.ECSP_5359,iECs_1301.ECs5235,iG2583_1286.G2583_5088,iJN746.PP_0977,iSBO_1134.SBO_4182,iSSON_1240.SSON_4443,iYL1228.KPN_04663,iZ_1308.Z5870 Bacteria 3J0B9@40117,COG0525@1,COG0525@2 NA|NA|NA J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner MAG.T1.5_02512 330214.NIDE1735 4.9e-114 417.9 Bacteria VP1245 Bacteria COG0784@1,COG0784@2 NA|NA|NA T Response regulator, receiver MAG.T1.5_02513 330214.NIDE1736 1.2e-113 416.0 Bacteria ko:K07025 ko00000 Bacteria COG1011@1,COG1011@2 NA|NA|NA S phosphatase activity MAG.T1.5_02514 330214.NIDE1737 2.3e-117 428.3 Nitrospirae cobB GO:0000726,GO:0003674,GO:0003824,GO:0003953,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006303,GO:0006464,GO:0006471,GO:0006476,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016787,GO:0016798,GO:0016799,GO:0019213,GO:0019538,GO:0030312,GO:0033554,GO:0033558,GO:0034641,GO:0034979,GO:0035601,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0070213,GO:0071214,GO:0071478,GO:0071479,GO:0071704,GO:0071944,GO:0090304,GO:0098732,GO:0104004,GO:0140096,GO:1901360,GO:1901564 ko:K12410 ko00000,ko01000 Bacteria 3J15J@40117,COG0846@1,COG0846@2 NA|NA|NA K Belongs to the sirtuin family. Class MAG.T1.5_02515 330214.NIDE1738 2e-239 834.7 Nitrospirae panE 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2643 Bacteria 3J0S5@40117,COG1893@1,COG1893@2,COG2041@1,COG2041@2 NA|NA|NA H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid MAG.T1.5_02516 330214.NIDE1739 2.2e-198 698.4 Bacteria norM ko:K03327 ko00000,ko02000 2.A.66.1 Bacteria COG0534@1,COG0534@2 NA|NA|NA V drug transmembrane transporter activity MAG.T1.5_02517 330214.NIDE1740 5.3e-257 893.3 Bacteria nusA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 ko:K02600 ko00000,ko03009,ko03021 Bacteria COG2251@1,COG2251@2 NA|NA|NA MAG.T1.5_02520 330214.NIDE1742 0.0 4847.0 Bacteria Bacteria COG0318@1,COG0318@2,COG1020@1,COG1020@2 NA|NA|NA Q D-alanine [D-alanyl carrier protein] ligase activity MAG.T1.5_02521 330214.NIDE1743 9.2e-271 939.1 Bacteria ko:K06160 ko02010,map02010 ko00000,ko00001,ko02000 3.A.1.113.2 Bacteria COG4615@1,COG4615@2 NA|NA|NA V microcin transport MAG.T1.5_02522 330214.NIDE1744 1.5e-74 286.2 Bacteria hetI 2.7.8.7 ko:K00997,ko:K06133 ko00770,map00770 R01625 RC00002 ko00000,ko00001,ko01000 Bacteria COG2091@1,COG2091@2 NA|NA|NA H lysine biosynthetic process via aminoadipic acid MAG.T1.5_02523 330214.NIDE1745 5.6e-65 253.8 Nitrospirae tadA GO:0002097,GO:0002100,GO:0003674,GO:0003824,GO:0004000,GO:0005488,GO:0006139,GO:0006382,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008251,GO:0008270,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016553,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0052717,GO:0071704,GO:0090304,GO:1901360 3.4.17.13,3.5.4.1,3.5.4.3,3.5.4.33,3.8.1.5,6.3.4.19 ko:K01297,ko:K01485,ko:K01487,ko:K01563,ko:K04075,ko:K11991 ko00230,ko00240,ko00330,ko00361,ko00625,ko01100,ko01120,map00230,map00240,map00330,map00361,map00625,map01100,map01120 R00974,R01411,R01676,R02922,R05284,R05367,R05368,R05369,R05370,R07669,R07670,R09597,R10223 RC00074,RC00204,RC00477,RC00514,RC00809,RC01317,RC01340,RC01341,RC02013,RC02633,RC02634 ko00000,ko00001,ko01000,ko01002,ko01011,ko03016 Bacteria 3J0PE@40117,COG0590@1,COG0590@2 NA|NA|NA FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) MAG.T1.5_02524 330214.NIDE1746 8.3e-129 466.8 Bacteria ko:K18682 ko03018,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria COG4372@1,COG4372@2,COG5343@1,COG5343@2 NA|NA|NA S Anti-sigma-K factor rskA MAG.T1.5_02525 330214.NIDE1747 3.7e-92 344.4 Bacteria ko:K03088 ko00000,ko03021 Bacteria COG1595@1,COG1595@2 NA|NA|NA K DNA-templated transcription, initiation MAG.T1.5_02526 330214.NIDE1748 1.9e-131 475.7 Bacteria Bacteria COG1819@1,COG1819@2 NA|NA|NA CG transferase activity, transferring hexosyl groups MAG.T1.5_02531 330214.NIDE3139 5.4e-175 620.9 Bacteria ko:K03287 ko00000 1.B.17 Bacteria COG1538@1,COG1538@2 NA|NA|NA MU efflux transmembrane transporter activity MAG.T1.5_02532 330214.NIDE3138 6.3e-92 344.0 Bacteria Bacteria COG0845@1,COG0845@2 NA|NA|NA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family MAG.T1.5_02533 330214.NIDE3137 2.1e-180 638.6 Bacteria ko:K01993,ko:K16922 ko00000,ko01002 Bacteria COG0845@1,COG0845@2 NA|NA|NA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family MAG.T1.5_02534 330214.NIDE3136 3.5e-286 990.7 Bacteria ko:K01993,ko:K13408,ko:K16922 ko04626,map04626 M00339 ko00000,ko00001,ko00002,ko01002,ko02000,ko02044 8.A.1 Bacteria COG0845@1,COG0845@2,COG1994@1,COG1994@2 NA|NA|NA S metallopeptidase activity MAG.T1.5_02535 330214.NIDE3135 1.3e-287 996.5 Bacteria 3.2.1.156 ko:K13735,ko:K15125,ko:K15531 ko05100,ko05133,map05100,map05133 ko00000,ko00001,ko00536,ko01000 GH8 Bacteria COG0726@1,COG0726@2,COG2911@1,COG2911@2,COG2931@1,COG2931@2,COG3210@1,COG3210@2 NA|NA|NA S protein secretion MAG.T1.5_02536 330214.NIDE1756 5.7e-139 500.4 Bacteria Bacteria COG1639@1,COG1639@2 NA|NA|NA T HDOD domain MAG.T1.5_02537 330214.NIDE1758 7.7e-102 376.7 Nitrospirae Bacteria 3J16V@40117,COG1814@1,COG1814@2 NA|NA|NA S VIT family MAG.T1.5_02538 330214.NIDE1759 6e-268 929.9 Nitrospirae Bacteria 3J0XZ@40117,COG0778@1,COG0778@2 NA|NA|NA C Nitroreductase MAG.T1.5_02540 330214.NIDE1761 2.8e-35 154.8 Bacteria Bacteria 2C8BN@1,32RKS@2 NA|NA|NA S Glycine-zipper domain MAG.T1.5_02541 330214.NIDE1762 4.1e-56 224.2 Bacteria Bacteria COG5652@1,COG5652@2 NA|NA|NA MAG.T1.5_02542 330214.NIDE1763 2.7e-58 231.1 Bacteria lpxC 3.5.1.108 ko:K02535 ko00540,ko01100,map00540,map01100 M00060 R04587 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko01005 Bacteria COG2204@1,COG2204@2 NA|NA|NA T phosphorelay signal transduction system MAG.T1.5_02543 330214.NIDE1765 0.0 1649.0 Bacteria ko:K15726 ko00000,ko02000 2.A.6.1.2 Bacteria COG3696@1,COG3696@2 NA|NA|NA P silver ion transport MAG.T1.5_02544 330214.NIDE1766 8.5e-146 523.5 Bacteria cusB ko:K07798,ko:K15727 ko02020,map02020 ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1,8.A.1.2.1 Bacteria COG0845@1,COG0845@2 NA|NA|NA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family MAG.T1.5_02545 330214.NIDE1767 5.2e-181 640.6 Nitrospirae cusC ko:K15725 ko00000,ko02000 1.B.17.2.2 Bacteria 3J1F2@40117,COG1538@1,COG1538@2 NA|NA|NA MU Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_02547 330214.NIDE1769 2.6e-257 894.4 Nitrospirae nuoL2 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 3J0AN@40117,COG1009@1,COG1009@2 NA|NA|NA CP NADH-quinone oxidoreductase MAG.T1.5_02548 330214.NIDE1770 0.0 1746.1 Nitrospirae ko:K09822 ko00000 Bacteria 3J0VY@40117,COG3002@1,COG3002@2 NA|NA|NA S Uncharacterized protein conserved in bacteria (DUF2309) MAG.T1.5_02549 330214.NIDE1771 4e-53 213.8 Nitrospirae ko:K04752 ko00000 Bacteria 3J17N@40117,COG0347@1,COG0347@2 NA|NA|NA K Evidence 2b Function of strongly homologous gene MAG.T1.5_02550 330214.NIDE1772 0.0 1128.6 Nitrospirae 2.7.13.3 ko:K02003,ko:K02484,ko:K07708,ko:K10942,ko:K14986 ko02020,ko05111,map02020,map05111 M00258,M00497,M00515,M00524 ko00000,ko00001,ko00002,ko01000,ko01001,ko02000,ko02022 3.A.1 Bacteria 3J0YT@40117,COG2203@1,COG2203@2,COG3852@1,COG3852@2 NA|NA|NA T GAF domain MAG.T1.5_02551 330214.NIDE1773 1.2e-207 729.2 Nitrospirae ko:K07714 ko02020,map02020 M00500 ko00000,ko00001,ko00002,ko02022 Bacteria 3J0YM@40117,COG2204@1,COG2204@2 NA|NA|NA T Bacterial regulatory protein, Fis family MAG.T1.5_02552 330214.NIDE0410 1.2e-111 409.5 Bacteria cysD 1.8.4.10,1.8.4.8,2.7.7.4 ko:K00390,ko:K00957 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R02021,R04929 RC00007,RC02809,RC02862,RC02889 ko00000,ko00001,ko00002,ko01000 Bacteria COG0175@1,COG0175@2 NA|NA|NA EH sulfate reduction MAG.T1.5_02553 330214.NIDE1770 0.0 1075.5 Nitrospirae ko:K09822 ko00000 Bacteria 3J0VY@40117,COG3002@1,COG3002@2 NA|NA|NA S Uncharacterized protein conserved in bacteria (DUF2309) MAG.T1.5_02554 479434.Sthe_3030 3.8e-55 222.6 Thermomicrobia folC GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 iLJ478.TM0166,iSB619.SA_RS08370 Bacteria 27Y4Y@189775,2G64M@200795,COG0285@1,COG0285@2 NA|NA|NA H Mur ligase family, glutamate ligase domain MAG.T1.5_02555 1162668.LFE_0769 2.5e-162 578.2 Nitrospirae icd 1.1.1.41,1.1.1.42 ko:K00030,ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R00709,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 3J0X4@40117,COG0473@1,COG0473@2 NA|NA|NA C Isocitrate/isopropylmalate dehydrogenase MAG.T1.5_02556 1162668.LFE_0770 1.1e-35 156.0 Bacteria 1.1.1.41 ko:K00030 ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010 R00709 RC00114 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria COG0473@1,COG0473@2 NA|NA|NA CE 3-isopropylmalate dehydrogenase activity MAG.T1.5_02560 76114.ebA5105 7.6e-152 543.9 Rhodocyclales cccA Bacteria 1N4E1@1224,2KYC1@206389,2VNWX@28216,COG1858@1,COG1858@2 NA|NA|NA C Cytochrome c MAG.T1.5_02561 1163617.SCD_n02431 9.7e-111 407.1 Betaproteobacteria glgC 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2768 Bacteria 1MVTC@1224,2VIP2@28216,COG0448@1,COG0448@2 NA|NA|NA H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans MAG.T1.5_02562 909663.KI867151_gene3005 5.1e-264 917.5 Syntrophobacterales treY GO:0000272,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009251,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0030978,GO:0030980,GO:0034637,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0047470,GO:0071704,GO:1901575,GO:1901576 2.4.1.25,5.4.99.15 ko:K00705,ko:K06044 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01824,R05196,R09995 RC00049 ko00000,ko00001,ko00002,ko01000 GH13,GH77 Bacteria 1QTVK@1224,2MQXA@213462,2WJX1@28221,42MEW@68525,COG3280@1,COG3280@2 NA|NA|NA G PFAM alpha amylase, catalytic MAG.T1.5_02563 153948.NAL212_2760 1.8e-35 155.2 Nitrosomonadales Bacteria 1PW2Z@1224,2AI5X@1,2WBP3@28216,318K6@2,373HR@32003 NA|NA|NA MAG.T1.5_02564 661478.OP10G_3987 2.4e-07 61.2 Bacteria ko:K21495 ko00000,ko02048 Bacteria 2DSE5@1,33FS0@2 NA|NA|NA MAG.T1.5_02565 870187.Thini_2229 8.7e-24 116.7 Proteobacteria vapC Bacteria 1N7ET@1224,COG4113@1,COG4113@2 NA|NA|NA S Toxic component of a toxin-antitoxin (TA) module. An RNase MAG.T1.5_02567 330214.NIDE3508 2.8e-119 434.9 Bacteria Bacteria 28N6F@1,2ZBBB@2 NA|NA|NA MAG.T1.5_02568 330214.NIDE3507 2.1e-60 238.8 Bacteria rimL 2.3.1.128 ko:K03790 ko00000,ko01000,ko03009 Bacteria COG1670@1,COG1670@2 NA|NA|NA J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins MAG.T1.5_02570 330214.NIDE3502 0.0 1609.0 Bacteria Bacteria COG3387@1,COG3387@2 NA|NA|NA G glucan 1,4-alpha-glucosidase activity MAG.T1.5_02571 63737.Npun_R0239 4.8e-100 371.3 Bacteria Bacteria COG2520@1,COG2520@2 NA|NA|NA J tRNA (guanine(37)-N(1))-methyltransferase activity MAG.T1.5_02572 1162668.LFE_0941 1.2e-27 129.8 Nitrospirae Bacteria 3J19G@40117,COG3558@1,COG3558@2 NA|NA|NA S Domain of unknown function (DUF5069) MAG.T1.5_02574 330214.NIDE3501 5.7e-237 827.0 Bacteria yciQ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria COG4907@1,COG4907@2 NA|NA|NA P membrane protein (DUF2207) MAG.T1.5_02575 330214.NIDE3500 9.1e-82 309.7 Bacteria lemA ko:K03744 ko00000 Bacteria COG1704@1,COG1704@2 NA|NA|NA S LemA family MAG.T1.5_02576 330214.NIDE3499 1.2e-29 136.3 Bacteria Bacteria 2C7J2@1,33AYB@2 NA|NA|NA MAG.T1.5_02577 1121377.KB906398_gene2383 2.8e-61 241.5 Bacteria Bacteria 2B5NQ@1,31YI3@2 NA|NA|NA S Domain of unknown function (DUF4188) MAG.T1.5_02578 404589.Anae109_2916 1.8e-62 246.5 Deltaproteobacteria 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 Bacteria 1PKS2@1224,2WPSR@28221,42T45@68525,COG2203@1,COG2203@2,COG3576@1,COG3576@2 NA|NA|NA T pyridoxamine 5'-phosphate oxidase-related FMN-binding MAG.T1.5_02579 861299.J421_5702 4.8e-12 77.4 Gemmatimonadetes Bacteria 1ZTKN@142182,COG4454@1,COG4454@2 NA|NA|NA MAG.T1.5_02580 330214.NIDE3498 9.5e-297 1025.8 Bacteria fhlA GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001150,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016043,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0022607,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035326,GO:0042802,GO:0043170,GO:0043254,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2000144,GO:2001141 ko:K02584,ko:K12146,ko:K12266,ko:K15836,ko:K21009 ko02020,ko02025,ko05132,map02020,map02025,map05132 ko00000,ko00001,ko03000 Bacteria COG2203@1,COG2203@2,COG3604@1,COG3604@2 NA|NA|NA KT transcription factor binding MAG.T1.5_02581 1121104.AQXH01000004_gene142 3.4e-124 451.8 Sphingobacteriia ndh 1.6.99.3 ko:K03885 ko00190,map00190 ko00000,ko00001,ko01000 Bacteria 1IQYG@117747,4NE0H@976,COG1252@1,COG1252@2 NA|NA|NA C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase MAG.T1.5_02583 330214.NIDE3496 3e-120 438.3 Nitrospirae dedA_2 Bacteria 3J1E4@40117,COG0586@1,COG0586@2,COG0607@1,COG0607@2 NA|NA|NA P Evidence 4 Homologs of previously reported genes of MAG.T1.5_02584 330214.NIDE3495 1.6e-145 522.3 Bacteria 1.3.3.6 ko:K00232 ko00071,ko00592,ko01040,ko01100,ko01110,ko01212,ko03320,ko04024,ko04146,map00071,map00592,map01040,map01100,map01110,map01212,map03320,map04024,map04146 M00087,M00113 R01175,R01279,R03777,R03857,R03990,R04751,R04754,R07888,R07892,R07896,R07934,R07950 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000 Bacteria COG3793@1,COG3793@2 NA|NA|NA P PFAM Mo-dependent nitrogenase MAG.T1.5_02586 330214.NIDE3494 1.8e-145 522.3 Bacteria ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 Bacteria COG0845@1,COG0845@2 NA|NA|NA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family MAG.T1.5_02587 330214.NIDE3493 0.0 1796.6 Bacteria acrB ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 Bacteria COG0841@1,COG0841@2 NA|NA|NA V transmembrane transporter activity MAG.T1.5_02589 330214.NIDE3491 1.7e-231 808.5 Nitrospirae oprM ko:K18139 ko01501,ko02024,map01501,map02024 M00642,M00643,M00647,M00718,M00768,M00822 ko00000,ko00001,ko00002,ko01504,ko02000 1.B.17,2.A.6.2 Bacteria 3J0N2@40117,COG1538@1,COG1538@2 NA|NA|NA M Evidence 2b Function of strongly homologous gene MAG.T1.5_02590 330214.NIDE3490 9.2e-58 229.9 Bacteria Bacteria COG5592@1,COG5592@2 NA|NA|NA I hemerythrin HHE cation binding domain MAG.T1.5_02591 330214.NIDE3489 1.7e-156 558.9 Bacteria 1.7.2.1 ko:K00368 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 Bacteria COG4243@1,COG4243@2 NA|NA|NA S quinone binding MAG.T1.5_02592 330214.NIDE3488 2.2e-43 181.4 Bacteria ko:K02612 ko00360,ko01120,map00360,map01120 R09838 RC02690 ko00000,ko00001 Bacteria COG2151@1,COG2151@2 NA|NA|NA L metal-sulfur cluster biosynthetic enzyme MAG.T1.5_02593 330214.NIDE3487 5.8e-164 583.9 Bacteria ko:K03088 ko00000,ko03021 Bacteria COG4941@1,COG4941@2 NA|NA|NA K sigma factor activity MAG.T1.5_02594 330214.NIDE3485 2.5e-23 114.4 Bacteria ko:K06996 ko00000 Bacteria COG3324@1,COG3324@2 NA|NA|NA E translation initiation factor activity MAG.T1.5_02595 330214.NIDE3484 2.3e-46 191.4 Bacteria Bacteria COG3795@1,COG3795@2 NA|NA|NA F YCII-related domain MAG.T1.5_02596 330214.NIDE3483 7.6e-45 186.4 Bacteria Bacteria COG3795@1,COG3795@2 NA|NA|NA F YCII-related domain MAG.T1.5_02597 330214.NIDE3482 3e-199 701.0 Bacteria Bacteria COG4447@1,COG4447@2 NA|NA|NA S cellulose binding MAG.T1.5_02598 330214.NIDE3481 8e-32 142.9 Bacteria 2.7.7.80,2.8.1.11 ko:K03636,ko:K21147 ko04122,map04122 R07459,R07461 RC00043 ko00000,ko00001,ko01000 Bacteria COG1977@1,COG1977@2 NA|NA|NA H Mo-molybdopterin cofactor metabolic process MAG.T1.5_02599 330214.NIDE3479 1.4e-58 232.3 Bacteria Bacteria COG3795@1,COG3795@2 NA|NA|NA F YCII-related domain MAG.T1.5_02600 452637.Oter_1314 5.6e-40 170.2 Opitutae ybaA 3.1.3.1 ko:K01077 ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020 M00126 R02135,R04620 RC00017 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 Bacteria 3K9QM@414999,46VQ8@74201,COG5507@1,COG5507@2 NA|NA|NA S Protein of unknown function (DUF1428) MAG.T1.5_02601 105422.BBPM01000006_gene6022 7.6e-41 173.3 Actinobacteria ko:K07032 ko00000 Bacteria 2IKVS@201174,COG3607@1,COG3607@2 NA|NA|NA S glyoxalase bleomycin resistance protein dioxygenase MAG.T1.5_02602 330214.NIDE3478 7.4e-77 293.5 Bacteria Bacteria 29IJ4@1,313M6@2 NA|NA|NA S Protein of unknown function (DUF1579) MAG.T1.5_02604 330214.NIDE3475 1.6e-168 599.0 Nitrospirae ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 Bacteria 3J10X@40117,COG0845@1,COG0845@2 NA|NA|NA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family MAG.T1.5_02605 330214.NIDE3474 0.0 1864.7 Nitrospirae ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 Bacteria 3J0FA@40117,COG0841@1,COG0841@2 NA|NA|NA V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family MAG.T1.5_02606 330214.NIDE3473 3.5e-242 844.0 Nitrospirae oprM ko:K18139 ko01501,ko02024,map01501,map02024 M00642,M00643,M00647,M00718,M00768,M00822 ko00000,ko00001,ko00002,ko01504,ko02000 1.B.17,2.A.6.2 Bacteria 3J0N2@40117,COG1538@1,COG1538@2 NA|NA|NA M Evidence 2b Function of strongly homologous gene MAG.T1.5_02612 330214.NIDE3467 6.8e-126 457.2 Bacteria Bacteria COG3673@1,COG3673@2 NA|NA|NA M conserved protein MAG.T1.5_02616 330214.NIDE3464 0.0 1242.3 Nitrospirae glgB GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901576 2.4.1.18,3.2.1.141 ko:K00700,ko:K01236 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110,R09995,R11256 RC00049 ko00000,ko00001,ko00002,ko01000,ko04147 CBM48,GH13 Bacteria 3J0WY@40117,COG0296@1,COG0296@2 NA|NA|NA G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position MAG.T1.5_02618 330214.NIDE3462 0.0 1228.0 Bacteria MA20_35625 Bacteria COG2202@1,COG2202@2,COG4191@1,COG4191@2 NA|NA|NA T Pas domain MAG.T1.5_02619 330214.NIDE3461 3e-99 368.2 Bacteria ko:K07714 ko02020,map02020 M00500 ko00000,ko00001,ko00002,ko02022 Bacteria COG2204@1,COG2204@2 NA|NA|NA T phosphorelay signal transduction system MAG.T1.5_02620 330214.NIDE3460 6.9e-80 303.5 Bacteria blc ko:K03098 ko00000,ko04147 Bacteria COG3040@1,COG3040@2 NA|NA|NA M lipid binding MAG.T1.5_02622 330214.NIDE3457 0.0 1124.8 Bacteria hlyB ko:K11004 ko02010,ko03070,ko05133,map02010,map03070,map05133 M00325,M00575 ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.109.1,3.A.1.109.2 Bacteria COG2274@1,COG2274@2 NA|NA|NA V protein secretion by the type I secretion system MAG.T1.5_02623 330214.NIDE3456 1.5e-197 695.7 Bacteria hlyD ko:K02022,ko:K11003,ko:K12532 ko02020,ko03070,ko05133,map02020,map03070,map05133 M00325,M00326,M00575 ko00000,ko00001,ko00002,ko02000,ko02044 8.A.1,8.A.1.3.1,8.A.1.3.2 Bacteria COG0845@1,COG0845@2 NA|NA|NA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family MAG.T1.5_02625 330214.NIDE3454 0.0 1416.7 Bacteria Bacteria COG2931@1,COG2931@2 NA|NA|NA Q calcium- and calmodulin-responsive adenylate cyclase activity MAG.T1.5_02626 330214.NIDE3452 3e-60 238.0 Bacteria rny ko:K18682 ko03018,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria COG2433@1,COG2433@2 NA|NA|NA MAG.T1.5_02627 330214.NIDE3451 1.8e-132 478.8 Nitrospirae Bacteria 3J14J@40117,COG1262@1,COG1262@2 NA|NA|NA S Evidence 4 Homologs of previously reported genes of MAG.T1.5_02628 330214.NIDE3450 2.4e-63 248.4 Bacteria ccoP ko:K00405 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 ko00000,ko00001,ko00002 3.D.4.3 Bacteria COG2010@1,COG2010@2 NA|NA|NA C Cytochrome c MAG.T1.5_02629 330214.NIDE3449 6.9e-212 743.0 Bacteria pilU ko:K02670 ko00000,ko02035,ko02044 3.A.15.2 Bacteria COG5008@1,COG5008@2 NA|NA|NA NU twitching motility protein MAG.T1.5_02630 330214.NIDE3448 2e-194 684.9 Nitrospirae pilT ko:K02669 ko00000,ko02035,ko02044 3.A.15.2 Bacteria 3J0YS@40117,COG2805@1,COG2805@2 NA|NA|NA NU Type II/IV secretion system protein MAG.T1.5_02631 330214.NIDE3447 8.2e-168 596.7 Nitrospirae bioF GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0030312,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0071944,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.29,2.3.1.47 ko:K00639,ko:K00652 ko00260,ko00780,ko01100,map00260,map00780,map01100 M00123,M00573,M00577 R00371,R03210,R10124 RC00004,RC00039,RC00394,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 iJN678.bioF,iNJ661.Rv1569 Bacteria 3J0XU@40117,COG0156@1,COG0156@2 NA|NA|NA H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide MAG.T1.5_02632 330214.NIDE3446 1.6e-117 429.1 Bacteria bamD ko:K05807,ko:K08309 ko00000,ko01000,ko01011,ko02000 1.B.33.1 GH23 Bacteria COG4105@1,COG4105@2 NA|NA|NA S cell envelope organization MAG.T1.5_02633 330214.NIDE3445 1.2e-221 775.8 Nitrospirae CP_0155 ko:K08307,ko:K12204 ko00000,ko01000,ko01011,ko02044 3.A.7.10.1,3.A.7.9.1 Bacteria 3J0J4@40117,COG0741@1,COG0741@2,COG1388@1,COG1388@2 NA|NA|NA M Lysin motif MAG.T1.5_02635 330214.NIDE3444 8.5e-207 726.1 Nitrospirae GO:0001505,GO:0003674,GO:0003824,GO:0004760,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006807,GO:0008150,GO:0008152,GO:0008453,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019265,GO:0019752,GO:0042133,GO:0042136,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.44,2.6.1.45,2.6.1.51 ko:K00830 ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146 M00346,M00532 R00369,R00372,R00585,R00588 RC00006,RC00008,RC00018 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 3J0FC@40117,COG0075@1,COG0075@2 NA|NA|NA E Evidence 2b Function of strongly homologous gene MAG.T1.5_02636 330214.NIDE3443 1e-282 978.8 Nitrospirae serA 1.1.1.3,1.1.1.399,1.1.1.95,4.3.1.19 ko:K00003,ko:K00058,ko:K01754,ko:K04767 ko00260,ko00270,ko00290,ko00300,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00290,map00300,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00017,M00018,M00020,M00570 R00220,R00996,R01513,R01773,R01775 RC00031,RC00087,RC00418,RC02600 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 3J0DZ@40117,COG0111@1,COG0111@2,COG4747@1,COG4747@2 NA|NA|NA E Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family MAG.T1.5_02637 330214.NIDE3442 4.5e-154 550.8 Nitrospirae hisZ 2.4.2.17,6.1.1.21 ko:K00765,ko:K01892,ko:K02502 ko00340,ko00970,ko01100,ko01110,ko01230,map00340,map00970,map01100,map01110,map01230 M00026,M00359,M00360 R01071,R03655 RC00055,RC00523,RC02819,RC03200 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 3J13R@40117,COG3705@1,COG3705@2 NA|NA|NA E Histidyl-tRNA synthetase MAG.T1.5_02638 330214.NIDE3441 7.7e-239 832.8 Nitrospirae dnaB 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 ko00000,ko00001,ko01000,ko03032 Bacteria 3J0EZ@40117,COG0305@1,COG0305@2 NA|NA|NA L Participates in initiation and elongation during chromosome replication MAG.T1.5_02639 330214.NIDE3440 5.8e-186 657.5 Nitrospirae Bacteria 3J0MH@40117,COG0457@1,COG0457@2 NA|NA|NA S Tetratricopeptide repeat MAG.T1.5_02640 330214.NIDE3439 4.8e-72 277.3 Bacteria pilA GO:0005575,GO:0005623,GO:0009289,GO:0042995,GO:0044464 ko:K02650 ko02020,map02020 ko00000,ko00001,ko02035,ko02044 3.A.15.2 Bacteria COG4968@1,COG4968@2 NA|NA|NA NU Prokaryotic N-terminal methylation motif MAG.T1.5_02642 330214.NIDE3438 1.8e-58 232.3 Bacteria pilA GO:0005575,GO:0005623,GO:0009289,GO:0042995,GO:0044464 ko:K02650 ko02020,map02020 ko00000,ko00001,ko02035,ko02044 3.A.15.2 Bacteria COG4968@1,COG4968@2 NA|NA|NA NU Prokaryotic N-terminal methylation motif MAG.T1.5_02643 330214.NIDE3437 5e-250 870.5 Bacteria GO:0003674,GO:0003824,GO:0006464,GO:0006486,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0016740,GO:0016757,GO:0019538,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0070085,GO:0071704,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 ko:K02847,ko:K13009,ko:K16705 ko00540,ko01100,map00540,map01100 M00080 ko00000,ko00001,ko00002,ko01000,ko01005,ko02000 9.B.67.4,9.B.67.5 Bacteria COG0457@1,COG0457@2,COG3307@1,COG3307@2 NA|NA|NA M -O-antigen MAG.T1.5_02644 1278073.MYSTI_06367 5.1e-27 128.6 Myxococcales Bacteria 1MZCR@1224,2WMT6@28221,2YW4K@29,42R7I@68525,COG0457@1,COG0457@2 NA|NA|NA S Tetratricopeptide repeat MAG.T1.5_02645 330214.NIDE3435 1.9e-154 552.0 Nitrospirae pilH ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 3J122@40117,COG1131@1,COG1131@2 NA|NA|NA V AAA domain, putative AbiEii toxin, Type IV TA system MAG.T1.5_02646 330214.NIDE3434 6.1e-108 397.1 Bacteria pilI Bacteria COG1277@1,COG1277@2 NA|NA|NA MAG.T1.5_02647 1379281.AVAG01000098_gene1704 3e-65 255.4 Desulfovibrionales rfbA ko:K01992,ko:K09690 ko02010,map02010 M00250,M00254 ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.103 Bacteria 1N0X3@1224,2MG6Q@213115,2WPTX@28221,42SZT@68525,COG1682@1,COG1682@2 NA|NA|NA GM ABC-2 type transporter MAG.T1.5_02648 1379281.AVAG01000098_gene1705 7.1e-72 277.3 Desulfovibrionales rfbB 3.6.3.38,3.6.3.40 ko:K01990,ko:K09689,ko:K09691,ko:K09693 ko02010,map02010 M00249,M00250,M00251,M00254 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.101,3.A.1.103,3.A.1.104 Bacteria 1MWWC@1224,2MA46@213115,2WMWA@28221,42NNW@68525,COG1134@1,COG1134@2 NA|NA|NA GM pfam abc MAG.T1.5_02649 445972.ANACOL_02159 2.9e-46 193.4 Ruminococcaceae ko:K20444 ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 Bacteria 1TQU0@1239,248HP@186801,3WHZS@541000,COG1215@1,COG1215@2,COG1216@1,COG1216@2,COG2227@1,COG2227@2 NA|NA|NA M Glycosyltransferase, group 2 family protein MAG.T1.5_02650 545243.BAEV01000108_gene2772 7.7e-90 337.8 Clostridiaceae gumK 2.4.1.264 ko:K13659 R09732 RC00005,RC00049 ko00000,ko01000,ko01003 GT70 Bacteria 1UFBR@1239,24DNE@186801,36HXV@31979,COG0438@1,COG0438@2 NA|NA|NA M Glycosyl transferases group 1 MAG.T1.5_02651 330214.NIDE3421 9.9e-147 526.6 Bacteria ko:K07011 ko00000 Bacteria COG0438@1,COG0438@2 NA|NA|NA M transferase activity, transferring glycosyl groups MAG.T1.5_02652 330214.NIDE3420 5.9e-170 603.6 Bacteria 2.7.8.33,2.7.8.35 ko:K02851 R08856 RC00002 ko00000,ko01000,ko01003,ko01005 Bacteria COG0472@1,COG0472@2 NA|NA|NA M phospho-N-acetylmuramoyl-pentapeptide-transferase activity MAG.T1.5_02653 330214.NIDE3419 1.7e-230 805.1 Bacteria 5.4.99.9 ko:K01854 ko00052,ko00520,map00052,map00520 R00505,R09009 RC00317,RC02396 ko00000,ko00001,ko01000 Bacteria COG1232@1,COG1232@2 NA|NA|NA H protoporphyrinogen oxidase activity MAG.T1.5_02654 330214.NIDE3418 1.3e-184 652.5 Bacteria Bacteria COG0438@1,COG0438@2 NA|NA|NA M transferase activity, transferring glycosyl groups MAG.T1.5_02655 330214.NIDE3417 1.2e-189 669.1 Nitrospirae degT Bacteria 3J09X@40117,COG0399@1,COG0399@2 NA|NA|NA E Belongs to the DegT DnrJ EryC1 family MAG.T1.5_02657 330214.NIDE3413 0.0 1146.0 Bacteria Bacteria COG0451@1,COG0451@2,COG0673@1,COG0673@2 NA|NA|NA S inositol 2-dehydrogenase activity MAG.T1.5_02661 330214.NIDE3409 1.4e-23 115.9 Bacteria ko:K06204 ko02026,map02026 ko00000,ko00001,ko03000,ko03009,ko03021 Bacteria COG1734@1,COG1734@2 NA|NA|NA T zinc ion binding MAG.T1.5_02662 330214.NIDE3408 0.0 1335.9 Bacteria ppk 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 ko00000,ko00001,ko01000,ko03019 iJN746.PP_5217 Bacteria COG0855@1,COG0855@2 NA|NA|NA P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) MAG.T1.5_02663 330214.NIDE3407 1.3e-146 525.8 Bacteria Bacteria 2DME8@1,32QX1@2 NA|NA|NA MAG.T1.5_02664 330214.NIDE3406 6e-310 1069.3 Nitrospirae ilvD GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0ES@40117,COG0129@1,COG0129@2 NA|NA|NA EG Dehydratase family MAG.T1.5_02665 671143.DAMO_0839 4.3e-59 235.0 Bacteria ko:K07480 ko00000 Bacteria COG1662@1,COG1662@2 NA|NA|NA L PFAM IS1 transposase MAG.T1.5_02667 765913.ThidrDRAFT_4550 1e-17 97.4 Proteobacteria Bacteria 1NK9V@1224,2F294@1,33V75@2 NA|NA|NA MAG.T1.5_02668 1121406.JAEX01000002_gene894 1.1e-62 246.5 Deltaproteobacteria Bacteria 1PXZG@1224,2WTES@28221,42X4N@68525,COG0454@1,COG0456@2,COG1432@1,COG1432@2 NA|NA|NA K Acetyltransferase (GNAT) domain MAG.T1.5_02669 330214.NIDE3405 1.1e-48 199.1 Bacteria Z012_07375 Bacteria COG3212@1,COG3212@2 NA|NA|NA T peptidase MAG.T1.5_02670 330214.NIDE3404 1.6e-79 302.4 Bacteria Bacteria COG3678@1,COG3678@2 NA|NA|NA NPTU ATP-independent chaperone mediated protein folding MAG.T1.5_02671 330214.NIDE3403 2.8e-98 364.8 Nitrospirae marC ko:K05595 ko00000,ko02000 2.A.95.1 Bacteria 3J0UZ@40117,COG2095@1,COG2095@2 NA|NA|NA U MarC family integral membrane protein MAG.T1.5_02672 330214.NIDE3402 3.2e-160 571.2 Nitrospirae ko:K05516 ko00000,ko03036,ko03110 Bacteria 3J0A7@40117,COG0484@1,COG0484@2 NA|NA|NA O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins MAG.T1.5_02673 330214.NIDE3401 1.1e-155 556.2 Bacteria ko:K10111,ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00204,M00206,M00207,M00491,M00602,M00605,M00606 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.1 Bacteria COG3842@1,COG3842@2 NA|NA|NA P ATPase activity MAG.T1.5_02674 330214.NIDE3400 5.6e-136 490.3 Bacteria ko:K02026 M00207 ko00000,ko00002,ko02000 3.A.1.1 Bacteria COG0395@1,COG0395@2 NA|NA|NA P glycerophosphodiester transmembrane transport MAG.T1.5_02675 330214.NIDE3399 3.8e-141 507.7 Bacteria sugA GO:0008150,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051704 ko:K02025,ko:K10237,ko:K15771 ko02010,map02010 M00204,M00207,M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.17,3.A.1.1.2 iNJ661.Rv1236 Bacteria COG1175@1,COG1175@2 NA|NA|NA P transmembrane transport MAG.T1.5_02676 330214.NIDE3398 1.6e-202 712.2 Bacteria thuE ko:K02027,ko:K10236 ko02010,map02010 M00204,M00207 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.17 Bacteria COG1653@1,COG1653@2 NA|NA|NA G carbohydrate transport MAG.T1.5_02678 330214.NIDE3397 2.1e-88 332.0 Bacteria 4.2.2.23 ko:K18197 ko00000,ko01000 PL11 Bacteria COG1470@1,COG1470@2,COG4733@1,COG4733@2 NA|NA|NA S cell adhesion involved in biofilm formation MAG.T1.5_02679 330214.NIDE3396 3.2e-159 567.8 Nitrospirae tilS 2.8.1.15,6.3.4.19 ko:K04075,ko:K14058,ko:K21947 R09597 RC02633,RC02634 ko00000,ko01000,ko03016 Bacteria 3J0JK@40117,COG0037@1,COG0037@2 NA|NA|NA H PP-loop family MAG.T1.5_02680 330214.NIDE3395 9.8e-15 85.5 Bacteria thiS ko:K03154 ko04122,map04122 ko00000,ko00001 Bacteria COG2104@1,COG2104@2 NA|NA|NA H thiamine diphosphate biosynthetic process MAG.T1.5_02682 330214.NIDE3393 5.2e-184 650.2 Nitrospirae galT 2.7.7.12 ko:K00965 ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917 M00362,M00554,M00632 R00955 RC00002 ko00000,ko00001,ko00002,ko01000 iLJ478.TM0896 Bacteria 3J0ER@40117,COG1085@1,COG1085@2 NA|NA|NA H Galactose-1-phosphate uridyl transferase, N-terminal domain MAG.T1.5_02683 330214.NIDE3392 0.0 1369.0 Nitrospirae Bacteria 3J0AQ@40117,COG1449@1,COG1449@2 NA|NA|NA G Glycosyl hydrolase family 57 MAG.T1.5_02684 330214.NIDE3391 2e-45 188.7 Bacteria Bacteria COG5652@1,COG5652@2 NA|NA|NA MAG.T1.5_02686 330214.NIDE3390 9.3e-162 576.2 Nitrospirae yrpG ko:K13315 ko00523,ko01130,map00523,map01130 M00798,M00799 R11051,R11474 RC00897,RC01516 ko00000,ko00001,ko00002,ko01000 Bacteria 3J154@40117,COG0667@1,COG0667@2 NA|NA|NA C Aldo/keto reductase family MAG.T1.5_02687 330214.NIDE3389 6.4e-175 620.2 Nitrospirae GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0006022,GO:0006040,GO:0006082,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017076,GO:0019200,GO:0019752,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046835,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564 2.7.1.221 ko:K07102 ko00520,ko01100,map00520,map01100 R08968,R11024 RC00002,RC00078 ko00000,ko00001,ko01000 Bacteria 3J15Y@40117,COG3178@1,COG3178@2 NA|NA|NA S Phosphotransferase enzyme family MAG.T1.5_02688 330214.NIDE3388 5.2e-112 410.6 Nitrospirae rmlA GO:0000166,GO:0000270,GO:0000287,GO:0001882,GO:0001884,GO:0002134,GO:0003674,GO:0003824,GO:0005488,GO:0006022,GO:0006040,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0019103,GO:0019752,GO:0030203,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044281,GO:0046872,GO:0070569,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564 2.7.7.13,2.7.7.24,2.7.7.99 ko:K00966,ko:K00973,ko:K00992 ko00051,ko00520,ko00521,ko00523,ko00525,ko01100,ko01110,ko01130,map00051,map00520,map00521,map00523,map00525,map01100,map01110,map01130 M00114,M00361,M00362,M00793 R00885,R02328,R11025 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0QW@40117,COG1208@1,COG1208@2 NA|NA|NA JM Nucleotidyl transferase MAG.T1.5_02689 330214.NIDE3387 4e-235 820.5 Bacteria Bacteria COG2204@1,COG2204@2 NA|NA|NA T phosphorelay signal transduction system MAG.T1.5_02690 330214.NIDE3386 2e-228 798.1 Nitrospirae Bacteria 3J0IE@40117,COG4198@1,COG4198@2 NA|NA|NA S Protein of unknown function (DUF1015) MAG.T1.5_02691 330214.NIDE3385 1.1e-184 652.5 Nitrospirae ispB GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663 2.5.1.30,2.5.1.90 ko:K00805,ko:K02523 ko00900,ko01110,map00900,map01110 R09247,R09248 RC00279 ko00000,ko00001,ko01000,ko01006 iYL1228.KPN_03597,ic_1306.c3945 Bacteria 3J0H0@40117,COG0142@1,COG0142@2 NA|NA|NA H Polyprenyl synthetase MAG.T1.5_02692 330214.NIDE3384 0.0 2871.3 Nitrospirae gltB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 Bacteria 3J0SV@40117,COG0067@1,COG0067@2,COG0069@1,COG0069@2,COG0070@1,COG0070@2 NA|NA|NA C Conserved region in glutamate synthase MAG.T1.5_02693 330214.NIDE3383 3.6e-271 940.3 Nitrospirae gltD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 iJN678.gltD,iNJ661.Rv3858c,iSB619.SA_RS02450 Bacteria 3J152@40117,COG0493@1,COG0493@2 NA|NA|NA C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster MAG.T1.5_02695 330214.NIDE3233 7.1e-43 179.9 Nitrospirae yeaO Bacteria 3J1F0@40117,COG3189@1,COG3189@2 NA|NA|NA S Protein of unknown function, DUF488 MAG.T1.5_02697 700598.Niako_1599 2.2e-14 85.5 Sphingobacteriia ntrX Bacteria 1IPCA@117747,4NE89@976,COG2204@1,COG2204@2 NA|NA|NA T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains MAG.T1.5_02699 330214.NIDE3226 0.0 1114.8 Bacteria pepF ko:K08602 ko00000,ko01000,ko01002 Bacteria COG1164@1,COG1164@2 NA|NA|NA E metalloendopeptidase activity MAG.T1.5_02701 330214.NIDE3224 3.8e-48 197.2 Bacteria hemY GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02498 ko00000 Bacteria COG3071@1,COG3071@2 NA|NA|NA H HemY protein MAG.T1.5_02702 330214.NIDE3222 4.1e-154 550.8 Nitrospirae acuC Bacteria 3J0P2@40117,COG0123@1,COG0123@2 NA|NA|NA BQ Histone deacetylase domain MAG.T1.5_02703 330214.NIDE3221 3.7e-235 820.5 Bacteria Bacteria COG3005@1,COG3005@2 NA|NA|NA C denitrification pathway MAG.T1.5_02704 330214.NIDE3220 3.2e-161 574.3 Bacteria rhdA 2.8.1.1,2.8.1.11,2.8.1.2 ko:K01011,ko:K21028 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 R01931,R03105,R03106,R07461 RC00214 ko00000,ko00001,ko01000 Bacteria COG2897@1,COG2897@2 NA|NA|NA P thiosulfate sulfurtransferase activity MAG.T1.5_02705 330214.NIDE3219 8.4e-12 76.6 Bacteria smbP Bacteria 2DQ5D@1,334TW@2 NA|NA|NA S Small metal-binding protein MAG.T1.5_02706 330214.NIDE3218 1.6e-127 462.2 Nitrospirae Bacteria 3J11H@40117,COG0388@1,COG0388@2 NA|NA|NA S Carbon-nitrogen hydrolase MAG.T1.5_02707 330214.NIDE3217 2.4e-98 364.8 Bacteria yqgE GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 ko:K07735 ko00000,ko03000 Bacteria COG1678@1,COG1678@2 NA|NA|NA K ribonucleoside-diphosphate reductase activity MAG.T1.5_02708 330214.NIDE3216 0.0 1678.3 Nitrospirae uvrA2 ko:K03701 ko03420,map03420 ko00000,ko00001,ko03400 Bacteria 3J0ZV@40117,COG0178@1,COG0178@2 NA|NA|NA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate MAG.T1.5_02709 330214.NIDE3215 6.5e-84 317.4 Bacteria nat 2.3.1.118,2.3.1.5 ko:K00622,ko:K00675 ko00232,ko00633,ko00983,ko01100,ko01110,ko01120,ko05204,map00232,map00633,map00983,map01100,map01110,map01120,map05204 R07940,R08036,R08248,R08250,R11902 RC00004,RC00416,RC00962,RC02961 ko00000,ko00001,ko01000 Bacteria COG2162@1,COG2162@2 NA|NA|NA Q arylamine N-acetyltransferase activity MAG.T1.5_02710 443144.GM21_1441 3.8e-47 195.3 Desulfuromonadales ko:K13572 ko00000,ko03051 Bacteria 1PE00@1224,2X5N2@28221,42T67@68525,43SWU@69541,COG2378@1,COG2378@2 NA|NA|NA K WYL domain MAG.T1.5_02713 555779.Dthio_PD3506 2.2e-106 392.5 Proteobacteria Bacteria 1NSGF@1224,2B1FR@1,31TWH@2 NA|NA|NA MAG.T1.5_02714 376733.IT41_03180 1.3e-17 97.8 Paracoccus dnaG ko:K02316 ko03030,map03030 ko00000,ko00001,ko01000,ko03032 Bacteria 1MUHC@1224,2PVV6@265,2TRU2@28211,COG0358@1,COG0358@2 NA|NA|NA L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication MAG.T1.5_02715 35841.BT1A1_1799 2.7e-38 164.9 Bacillus Bacteria 1V6HC@1239,1ZH3D@1386,4HJA7@91061,COG2445@1,COG2445@2 NA|NA|NA S Protein of unknown function DUF86 MAG.T1.5_02716 330214.NIDE0028 1.9e-41 175.3 Bacteria Bacteria COG1669@1,COG1669@2 NA|NA|NA S nucleotidyltransferase activity MAG.T1.5_02717 1454004.AW11_01274 1.2e-25 122.1 Betaproteobacteria ko:K03676,ko:K06191 ko00000,ko03110 Bacteria 1N8R4@1224,2WHH0@28216,COG0695@1,COG0695@2 NA|NA|NA O Thioredoxin domain MAG.T1.5_02718 251221.35214162 1.3e-23 115.9 Cyanobacteria ytcD Bacteria 1G94R@1117,COG1733@1,COG1733@2 NA|NA|NA K Transcriptional regulator MAG.T1.5_02720 330214.NIDE3206 7.3e-264 916.0 Bacteria 1.10.3.1,1.14.18.1 ko:K00422,ko:K00505 ko00350,ko00950,ko00965,ko01100,ko01110,ko04916,map00350,map00950,map00965,map01100,map01110,map04916 M00042 R00031,R00045,R00731,R02078,R02363,R02383,R04693,R04884 RC00046,RC00150,RC00180 ko00000,ko00001,ko00002,ko01000 Bacteria 2DBCY@1,2Z8GH@2 NA|NA|NA S PFAM Tyrosinase MAG.T1.5_02721 330214.NIDE3201 1.1e-53 215.7 Bacteria Bacteria 2C4PS@1,2ZHNK@2 NA|NA|NA MAG.T1.5_02722 330214.NIDE3200 1.3e-161 575.9 Nitrospirae rnz GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267 3.1.26.11 ko:K00784 ko03013,map03013 ko00000,ko00001,ko01000,ko03016 Bacteria 3J113@40117,COG1234@1,COG1234@2 NA|NA|NA S tRNA 3'-trailer cleavage MAG.T1.5_02724 330214.NIDE3198 6e-264 916.4 Bacteria tolC ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 Bacteria COG1538@1,COG1538@2 NA|NA|NA MU efflux transmembrane transporter activity MAG.T1.5_02726 330214.NIDE3195 1.2e-194 685.6 Nitrospirae MA20_17390 ko:K00713,ko:K06338 ko00000,ko01000,ko01003,ko01005 Bacteria 3J120@40117,COG0438@1,COG0438@2 NA|NA|NA M Glycosyltransferase Family 4 MAG.T1.5_02727 330214.NIDE3194 5.2e-213 746.9 Nitrospirae Bacteria 3J0RT@40117,COG0477@1,COG2814@2 NA|NA|NA EGP Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_02728 330214.NIDE3193 2e-74 286.2 Bacteria tolA 2.7.13.3 ko:K03407,ko:K03646,ko:K04065,ko:K06596,ko:K07277,ko:K12065,ko:K13593 ko02020,ko02025,ko02030,ko04112,map02020,map02025,map02030,map04112 M00506,M00507 ko00000,ko00001,ko00002,ko01000,ko01001,ko02000,ko02022,ko02035,ko02044,ko03029 1.B.33,2.C.1.2,3.A.7.11.1 Bacteria COG2823@1,COG2823@2,COG3170@1,COG3170@2 NA|NA|NA S hyperosmotic response MAG.T1.5_02729 330214.NIDE3192 1.2e-201 709.1 Bacteria Bacteria COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily MAG.T1.5_02730 330214.NIDE3191 0.0 1395.2 Nitrospirae MA20_17380 Bacteria 3J0Z8@40117,COG3408@1,COG3408@2 NA|NA|NA G Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain MAG.T1.5_02731 330214.NIDE3190 7.2e-188 663.7 Bacteria Bacteria COG2234@1,COG2234@2 NA|NA|NA DZ aminopeptidase activity MAG.T1.5_02734 247490.KSU1_B0516 6.2e-09 68.2 Planctomycetes 2.7.3.13,2.7.9.1,2.7.9.2 ko:K01006,ko:K01007,ko:K22424 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173,M00374 R00199,R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 Bacteria 2IZTQ@203682,COG3848@1,COG3848@2 NA|NA|NA T Pyruvate phosphate dikinase MAG.T1.5_02735 330214.NIDE3327 1.4e-36 158.7 Bacteria rbpA Bacteria COG0724@1,COG0724@2 NA|NA|NA K RNA recognition motif MAG.T1.5_02736 330214.NIDE3184 7.2e-229 799.7 Bacteria rhlE 3.6.4.13 ko:K11927 ko03018,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria COG0513@1,COG0513@2 NA|NA|NA L helicase activity MAG.T1.5_02737 330214.NIDE3183 1.7e-72 278.9 Bacteria slyD 5.2.1.8 ko:K03775 ko00000,ko01000,ko03110 Bacteria COG1047@1,COG1047@2 NA|NA|NA O modulation by symbiont of host adenylate cyclase-mediated signal transduction MAG.T1.5_02738 330214.NIDE3376 7.5e-63 246.5 Bacteria Bacteria 2ETMV@1,33M5M@2 NA|NA|NA S Domain of unknown function (DUF5069) MAG.T1.5_02740 330214.NIDE3374 6.5e-138 497.3 Bacteria Bacteria 28I4Y@1,2Z88D@2 NA|NA|NA MAG.T1.5_02741 330214.NIDE3373 1.8e-154 552.0 Bacteria ko:K20333 ko02024,map02024 ko00000,ko00001 Bacteria COG1262@1,COG1262@2 NA|NA|NA T PFAM Formylglycine-generating sulfatase enzyme MAG.T1.5_02744 330214.NIDE3370 5.5e-107 393.7 Nitrospirae ycbL GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019243,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0051596,GO:0061727,GO:0071704,GO:1901575,GO:1901615 3.1.2.6 ko:K01069 ko00620,map00620 R01736 RC00004,RC00137 ko00000,ko00001,ko01000 Bacteria 3J0VN@40117,COG0491@1,COG0491@2 NA|NA|NA S Metallo-beta-lactamase superfamily MAG.T1.5_02745 330214.NIDE3368 7.1e-60 236.9 Bacteria yqdE ko:K08999 ko00000 Bacteria COG1259@1,COG1259@2 NA|NA|NA K PFAM Uncharacterised ACR, COG1259 MAG.T1.5_02747 330214.NIDE3366 4.1e-181 640.6 Nitrospirae trpS GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 3J0A0@40117,COG0180@1,COG0180@2 NA|NA|NA J tRNA synthetases class I (W and Y) MAG.T1.5_02748 330214.NIDE3365 0.0 1133.6 Nitrospirae ko:K01999 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 3J18U@40117,COG0683@1,COG0683@2 NA|NA|NA E Periplasmic binding protein MAG.T1.5_02749 330214.NIDE3364 7.1e-133 480.3 Nitrospirae xerD GO:0000150,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009314,GO:0009628,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0071139,GO:0071704,GO:0090304,GO:0140097,GO:1901360 ko:K03733,ko:K04763 ko00000,ko03036 Bacteria 3J0KV@40117,COG4974@1,COG4974@2 NA|NA|NA D Phage integrase, N-terminal SAM-like domain MAG.T1.5_02752 330214.NIDE3363 4.7e-110 404.1 Nitrospirae tolQ ko:K03561,ko:K03562 ko01120,map01120 ko00000,ko02000 1.A.30.2.1,1.A.30.2.2 Bacteria 3J0PX@40117,COG0811@1,COG0811@2 NA|NA|NA U MotA/TolQ/ExbB proton channel family MAG.T1.5_02753 330214.NIDE3362 1.3e-70 272.3 Nitrospirae tolR ko:K03559,ko:K03560 ko00000,ko02000 1.A.30.2.1,1.A.30.2.2 Bacteria 3J0T6@40117,COG0848@1,COG0848@2 NA|NA|NA U Biopolymer transport protein ExbD/TolR MAG.T1.5_02754 330214.NIDE3361 3e-157 561.6 Bacteria ko:K03646,ko:K03832 ko00000,ko02000 2.C.1.1,2.C.1.2 Bacteria COG0810@1,COG0810@2 NA|NA|NA M energy transducer activity MAG.T1.5_02755 330214.NIDE3360 4.2e-173 614.4 Nitrospirae tolB GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0009719,GO:0009987,GO:0010033,GO:0010243,GO:0015031,GO:0015833,GO:0015893,GO:0017038,GO:0019534,GO:0019904,GO:0022857,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0032991,GO:0033036,GO:0042221,GO:0042493,GO:0042597,GO:0042886,GO:0042891,GO:0043213,GO:0044464,GO:0044877,GO:0045184,GO:0046677,GO:0046678,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0070887,GO:0071236,GO:0071237,GO:0071310,GO:0071417,GO:0071495,GO:0071702,GO:0071705,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1901998 ko:K03641 ko00000,ko02000 2.C.1.2 Bacteria 3J0U9@40117,COG0823@1,COG0823@2 NA|NA|NA U WD40-like Beta Propeller Repeat MAG.T1.5_02756 330214.NIDE3359 3.4e-114 417.9 Nitrospirae pal ko:K03640 ko00000,ko02000 2.C.1.2 Bacteria 3J17Q@40117,COG2885@1,COG2885@2 NA|NA|NA M Belongs to the ompA family MAG.T1.5_02757 330214.NIDE3358 5.2e-221 773.9 Bacteria ko:K01991,ko:K02557,ko:K07161,ko:K07484 ko02026,ko02030,ko02040,map02026,map02030,map02040 ko00000,ko00001,ko02000,ko02035 1.A.30.1,1.B.18 Bacteria COG1729@1,COG1729@2,COG4372@1,COG4372@2 NA|NA|NA Q Transposase MAG.T1.5_02758 330214.NIDE3357 3.5e-71 275.0 Nitrospirae cpoB Bacteria 3J0RE@40117,COG1729@1,COG1729@2 NA|NA|NA S Outer membrane lipoprotein MAG.T1.5_02759 330214.NIDE3356 2.9e-270 937.6 Nitrospirae mutL GO:0000018,GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0032300,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1990391 ko:K03572 ko03430,map03430 ko00000,ko00001,ko03400 Bacteria 3J0GN@40117,COG0323@1,COG0323@2 NA|NA|NA L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex MAG.T1.5_02760 330214.NIDE3355 7.3e-141 506.9 Nitrospirae miaA GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 Bacteria 3J0KS@40117,COG0324@1,COG0324@2 NA|NA|NA J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) MAG.T1.5_02761 330214.NIDE3354 4.4e-142 510.8 Nitrospirae mtnP GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004731,GO:0006082,GO:0006139,GO:0006144,GO:0006168,GO:0006520,GO:0006555,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009112,GO:0009113,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0017061,GO:0017144,GO:0018130,GO:0019438,GO:0019509,GO:0019752,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0055086,GO:0071265,GO:0071267,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.28 ko:K00772 ko00270,ko01100,map00270,map01100 M00034 R01402 RC00063,RC02819 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2684 Bacteria 3J0HC@40117,COG0005@1,COG0005@2 NA|NA|NA F Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates MAG.T1.5_02762 330214.NIDE3353 3.7e-168 597.4 Nitrospirae adoK GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004001,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005975,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019200,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032552,GO:0032553,GO:0032554,GO:0032555,GO:0032559,GO:0032560,GO:0032561,GO:0032567,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046390,GO:0046483,GO:0046835,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.15,2.7.1.20 ko:K00852,ko:K00856 ko00030,ko00230,ko01100,map00030,map00230,map01100 R00185,R01051,R02750 RC00002,RC00017 ko00000,ko00001,ko01000 iAF987.Gmet_2683 Bacteria 3J0ZT@40117,COG0524@1,COG0524@2 NA|NA|NA G pfkB family carbohydrate kinase MAG.T1.5_02763 330214.NIDE3352 3.2e-79 301.6 Nitrospirae sscB ko:K02656 ko00000,ko02035,ko02044 Bacteria 3J0V4@40117,COG3063@1,COG3063@2 NA|NA|NA NU Tetratricopeptide repeat MAG.T1.5_02764 330214.NIDE3351 7.5e-116 423.7 Nitrospirae Bacteria 3J1CJ@40117,COG1426@1,COG1426@2 NA|NA|NA S Helix-turn-helix domain MAG.T1.5_02765 330214.NIDE3350 1.5e-77 295.4 Nitrospirae Bacteria 3J17C@40117,COG2010@1,COG2010@2 NA|NA|NA C Cytochrome C oxidase, cbb3-type, subunit III MAG.T1.5_02766 330214.NIDE3349 5.5e-232 810.4 Nitrospirae Bacteria 3J0QX@40117,COG4249@1,COG4249@2 NA|NA|NA S Evidence 5 No homology to any previously reported sequences MAG.T1.5_02767 330214.NIDE3348 1e-273 949.1 Bacteria ko:K00612 ko00000,ko01000 Bacteria COG2192@1,COG2192@2 NA|NA|NA O nodulation MAG.T1.5_02768 330214.NIDE3347 1.4e-212 745.7 Bacteria Bacteria COG1287@1,COG1287@2 NA|NA|NA S oligosaccharyl transferase activity MAG.T1.5_02769 330214.NIDE3346 3.1e-110 404.8 Bacteria Bacteria COG1215@1,COG1215@2 NA|NA|NA M transferase activity, transferring glycosyl groups MAG.T1.5_02771 330214.NIDE3344 1.2e-227 795.8 Nitrospirae rseP GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008237,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019219,GO:0019222,GO:0019538,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031975,GO:0042597,GO:0043170,GO:0043856,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0045152,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:0140110,GO:1901564,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 3.4.21.107 ko:K04771,ko:K11749 ko01503,ko02020,ko02024,ko04112,map01503,map02020,map02024,map04112 M00728 ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 Bacteria 3J0VW@40117,COG0265@1,COG0265@2,COG0750@1,COG0750@2 NA|NA|NA O Trypsin MAG.T1.5_02772 330214.NIDE3343 2.2e-163 581.6 Nitrospirae tatC GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 ko:K03118 ko03060,ko03070,map03060,map03070 M00336 ko00000,ko00001,ko00002,ko02044 2.A.64 Bacteria 3J0PJ@40117,COG0805@1,COG0805@2 NA|NA|NA U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes MAG.T1.5_02773 330214.NIDE3342 1.1e-183 649.0 Nitrospirae ko:K03593 ko00000,ko03029,ko03036 Bacteria 3J10K@40117,COG0489@1,COG0489@2 NA|NA|NA D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP MAG.T1.5_02774 330214.NIDE3341 1.3e-224 785.4 Nitrospirae moeA 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 R09735 RC03462 ko00000,ko00001,ko01000 Bacteria 3J0MX@40117,COG0303@1,COG0303@2 NA|NA|NA H Probable molybdopterin binding domain MAG.T1.5_02775 330214.NIDE3340 9.7e-86 322.8 Bacteria mobB GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 2.10.1.1,2.7.7.77 ko:K03750,ko:K03753,ko:K13818 ko00790,ko01100,map00790,map01100 R09735,R11581 RC03462 ko00000,ko00001,ko01000 iB21_1397.B21_03691,iBWG_1329.BWG_3527,iECBD_1354.ECBD_4174,iECDH1ME8569_1439.ECDH1ME8569_3728,iEcDH1_1363.EcDH1_4130,iJO1366.b3856,iSbBS512_1146.SbBS512_E4328,iY75_1357.Y75_RS17805 Bacteria COG1763@1,COG1763@2 NA|NA|NA H Mo-molybdopterin cofactor metabolic process MAG.T1.5_02776 330214.NIDE3339 5.7e-129 466.8 Bacteria ko:K02569,ko:K03532,ko:K15876 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00530 R05712 RC00176 ko00000,ko00001,ko00002,ko02000 5.A.3.4 Bacteria COG3005@1,COG3005@2 NA|NA|NA C denitrification pathway MAG.T1.5_02777 330214.NIDE3338 2.7e-113 414.8 Nitrospirae MA20_23390 ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 3J116@40117,COG1131@1,COG1131@2 NA|NA|NA V AAA domain, putative AbiEii toxin, Type IV TA system MAG.T1.5_02779 330214.NIDE3335 2.3e-134 485.0 Bacteria ko:K01421,ko:K01992,ko:K09690 ko02010,map02010 M00250,M00254 ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.103 Bacteria COG1682@1,COG1682@2 NA|NA|NA GM macromolecule localization MAG.T1.5_02780 330214.NIDE3334 1e-111 409.5 Bacteria ko:K07394 ko00000 Bacteria COG3751@1,COG3751@2 NA|NA|NA O 2OG-Fe(II) oxygenase superfamily MAG.T1.5_02781 330214.NIDE3332 8e-212 743.0 Nitrospirae 3.6.3.38 ko:K01990,ko:K09689,ko:K09691 ko02010,map02010 M00249,M00250,M00254 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.101,3.A.1.103 Bacteria 3J142@40117,COG1134@1,COG1134@2 NA|NA|NA GM Evidence 2b Function of strongly homologous gene MAG.T1.5_02782 330214.NIDE3331 9.5e-28 129.0 Bacteria ko:K02078 ko00000,ko00001 Bacteria COG0236@1,COG0236@2 NA|NA|NA IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis MAG.T1.5_02783 330214.NIDE3330 4.5e-177 627.9 Bacteria fapR Bacteria COG1028@1,COG1028@2,COG2030@1,COG2030@2 NA|NA|NA I dehydratase MAG.T1.5_02784 330214.NIDE3329 2.7e-296 1024.2 Bacteria Bacteria COG3882@1,COG3882@2 NA|NA|NA Q phosphopantetheine binding MAG.T1.5_02785 330214.NIDE3328 3.4e-70 271.6 Bacteria cysE 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 Bacteria COG1045@1,COG1045@2 NA|NA|NA E serine acetyltransferase MAG.T1.5_02786 330214.NIDE3327 2.9e-48 197.6 Bacteria rbpA Bacteria COG0724@1,COG0724@2 NA|NA|NA K RNA recognition motif MAG.T1.5_02787 1205680.CAKO01000002_gene2136 4.7e-25 121.7 Alphaproteobacteria 2.7.3.13,2.7.9.1,2.7.9.2 ko:K01006,ko:K01007,ko:K22424 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173,M00374 R00199,R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 Bacteria 1R7DS@1224,2U3SK@28211,COG3848@1,COG3848@2 NA|NA|NA T Pyruvate phosphate dikinase MAG.T1.5_02788 330214.NIDE3325 4e-42 178.7 Nitrospirae Bacteria 3J1EU@40117,COG0457@1,COG0457@2 NA|NA|NA S Tetratricopeptide repeat MAG.T1.5_02789 330214.NIDE3324 3.3e-230 804.3 Nitrospirae ko:K18139 ko01501,ko02024,map01501,map02024 M00642,M00643,M00647,M00718,M00768,M00822 ko00000,ko00001,ko00002,ko01504,ko02000 1.B.17,2.A.6.2 Bacteria 3J0N2@40117,COG1538@1,COG1538@2 NA|NA|NA M Evidence 2b Function of strongly homologous gene MAG.T1.5_02790 330214.NIDE3323 1.1e-143 516.2 Bacteria ko:K01993 ko00000 Bacteria COG0845@1,COG0845@2 NA|NA|NA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family MAG.T1.5_02791 330214.NIDE3322 2.6e-111 408.3 Nitrospirae hrtA ko:K02003,ko:K09810,ko:K09814 ko02010,map02010 M00255,M00257,M00258 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.125 Bacteria 3J10N@40117,COG1136@1,COG1136@2 NA|NA|NA V Evidence 2b Function of strongly homologous gene MAG.T1.5_02792 330214.NIDE3321 4.8e-178 630.6 Bacteria ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria COG0577@1,COG0577@2 NA|NA|NA V efflux transmembrane transporter activity MAG.T1.5_02794 330214.NIDE3319 6.9e-308 1062.8 Bacteria nifA ko:K02584,ko:K12146,ko:K15836 ko02020,map02020 ko00000,ko00001,ko03000 Bacteria COG3604@1,COG3604@2 NA|NA|NA KT transcription factor binding MAG.T1.5_02795 330214.NIDE3318 5.6e-100 370.5 Bacteria Bacteria COG1293@1,COG1293@2 NA|NA|NA K actin binding MAG.T1.5_02796 330214.NIDE2954 1.8e-76 292.4 Bacteria 2.1.1.80,3.1.1.61 ko:K13924 ko02020,ko02030,map02020,map02030 M00506 ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 Bacteria COG0419@1,COG0419@2 NA|NA|NA L ATPase involved in DNA repair MAG.T1.5_02797 330214.NIDE2957 0.0 1272.3 Bacteria Bacteria COG0222@1,COG0222@2 NA|NA|NA J mitochondrial gene expression MAG.T1.5_02799 330214.NIDE2959 0.0 2411.3 Bacteria ko:K20444 ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 Bacteria COG0845@1,COG0845@2 NA|NA|NA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family MAG.T1.5_02800 330214.NIDE2960 2.4e-237 828.2 Bacteria Bacteria 28H5N@1,2Z7I8@2 NA|NA|NA MAG.T1.5_02801 1173023.KE650771_gene1001 7.6e-31 139.8 Stigonemataceae Bacteria 1GKII@1117,1JM9T@1189,COG3657@1,COG3657@2 NA|NA|NA S Phage derived protein Gp49-like (DUF891) MAG.T1.5_02802 443143.GM18_2548 6e-24 116.7 delta/epsilon subdivisions Bacteria 1N75D@1224,42V7U@68525,COG3636@1,COG3636@2 NA|NA|NA K Addiction module antidote protein MAG.T1.5_02804 288000.BBta_4943 5.5e-33 148.3 Bradyrhizobiaceae ko:K07451,ko:K07453 ko00000,ko01000,ko02048 Bacteria 1MZRA@1224,2U8HQ@28211,3K254@41294,COG3183@1,COG3183@2 NA|NA|NA V HNH nucleases MAG.T1.5_02805 661478.OP10G_1892 1.9e-13 82.0 Bacteria Bacteria COG5606@1,COG5606@2 NA|NA|NA MAG.T1.5_02806 1034943.BN1094_00618 4.5e-31 140.6 Legionellales Bacteria 1JEPD@118969,1MZC9@1224,1S8WB@1236,COG4679@1,COG4679@2 NA|NA|NA S Phage derived protein Gp49-like (DUF891) MAG.T1.5_02807 330214.NIDE2963 3.9e-38 164.5 Nitrospirae Bacteria 3J13N@40117,COG1846@1,COG1846@2 NA|NA|NA K helix_turn_helix multiple antibiotic resistance protein MAG.T1.5_02808 671143.DAMO_1803 3.7e-18 98.2 Bacteria Bacteria 2EAWU@1,334Y1@2 NA|NA|NA S Hemerythrin HHE cation binding domain MAG.T1.5_02810 330214.NIDE2963 1.1e-80 306.2 Nitrospirae Bacteria 3J13N@40117,COG1846@1,COG1846@2 NA|NA|NA K helix_turn_helix multiple antibiotic resistance protein MAG.T1.5_02811 330214.NIDE2964 1e-178 632.9 Nitrospirae mexE ko:K18901,ko:K19586 M00698,M00767 ko00000,ko00002,ko01504,ko02000 2.A.6.2,2.A.6.2.47,8.A.1 Bacteria 3J11U@40117,COG0845@1,COG0845@2 NA|NA|NA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family MAG.T1.5_02812 330214.NIDE2965 0.0 1933.7 Nitrospirae mexF ko:K18299,ko:K18902,ko:K19585 M00641,M00698,M00767 ko00000,ko00002,ko01504,ko02000 2.A.6.2,2.A.6.2.16,2.A.6.2.47 Bacteria 3J0FA@40117,COG0841@1,COG0841@2 NA|NA|NA V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family MAG.T1.5_02813 330214.NIDE3158 6.2e-42 177.9 Bacteria ko:K02020 ko02010,map02010 M00189 ko00000,ko00001,ko00002,ko02000 3.A.1.8 Bacteria COG0725@1,COG0725@2 NA|NA|NA P tungstate binding MAG.T1.5_02814 323261.Noc_1277 1.1e-185 656.4 Chromatiales Bacteria 1MU48@1224,1RMBN@1236,1WXV4@135613,COG0841@1,COG0841@2 NA|NA|NA V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family MAG.T1.5_02815 857087.Metme_1661 9.4e-210 736.5 Methylococcales Bacteria 1MU48@1224,1RQ6V@1236,1XDWC@135618,COG0841@1,COG0841@2 NA|NA|NA V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family MAG.T1.5_02816 1134912.AJTV01000001_gene1418 6.8e-122 444.1 Methylocystaceae Bacteria 1NQZ0@1224,2U105@28211,36ZBI@31993,COG0845@1,COG0845@2 NA|NA|NA M Biotin-lipoyl like MAG.T1.5_02817 243233.MCA0176 6.7e-194 683.7 Methylococcales Bacteria 1MUA8@1224,1RQ6B@1236,1XEVK@135618,COG1538@1,COG1538@2 NA|NA|NA MU Outer membrane efflux protein MAG.T1.5_02818 179408.Osc7112_1134 5.3e-07 62.8 Oscillatoriales Bacteria 1G4KP@1117,1H7YH@1150,28MWQ@1,2ZB40@2 NA|NA|NA MAG.T1.5_02820 330214.NIDE2967 0.0 1590.1 Bacteria ko:K02014 ko00000,ko02000 1.B.14 Bacteria COG4774@1,COG4774@2 NA|NA|NA P siderophore transport MAG.T1.5_02822 330214.NIDE2969 1.3e-193 682.2 Bacteria aroF GO:0003674,GO:0003824,GO:0003849,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019438,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2375,iAPECO1_1312.APECO1_3932,iECOK1_1307.ECOK1_2946,iECS88_1305.ECS88_2787,iUMN146_1321.UM146_03705,iUTI89_1310.UTI89_C2934 Bacteria COG0722@1,COG0722@2 NA|NA|NA E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) MAG.T1.5_02823 330214.NIDE2970 2.5e-133 481.5 Nitrospirae ycfH GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575 ko:K03424 ko00000,ko01000 Bacteria 3J0KM@40117,COG0084@1,COG0084@2 NA|NA|NA L TatD related DNase MAG.T1.5_02824 330214.NIDE2971 1.1e-74 286.2 Nitrospirae yacP ko:K06962 ko00000 Bacteria 3J0TU@40117,COG3688@1,COG3688@2 NA|NA|NA S YacP-like NYN domain MAG.T1.5_02825 330214.NIDE2972 2.6e-186 658.3 Nitrospirae 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 Bacteria 3J0MT@40117,COG0860@1,COG0860@2 NA|NA|NA M Ami_3 MAG.T1.5_02826 330214.NIDE2973 2.4e-112 411.8 Nitrospirae truA GO:0000049,GO:0001522,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0030312,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363 5.4.99.12 ko:K06173 ko00000,ko01000,ko03016 Bacteria 3J0PM@40117,COG0101@1,COG0101@2 NA|NA|NA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs MAG.T1.5_02827 330214.NIDE2975 2.4e-105 388.3 Nitrospirae cysE GO:0000096,GO:0000097,GO:0000098,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009001,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009070,GO:0009087,GO:0009987,GO:0016053,GO:0016054,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS02865,iYO844.BSU00930 Bacteria 3J11G@40117,COG1045@1,COG1045@2 NA|NA|NA E Serine acetyltransferase, N-terminal MAG.T1.5_02828 330214.NIDE2976 4.1e-78 297.4 Nitrospirae ispF GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006629,GO:0006720,GO:0006721,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008270,GO:0008299,GO:0008610,GO:0008685,GO:0009058,GO:0009108,GO:0009987,GO:0016114,GO:0016829,GO:0016849,GO:0030145,GO:0040007,GO:0042180,GO:0042181,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051483,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.1.1.228,2.7.7.60,4.6.1.12 ko:K00554,ko:K00991,ko:K01770,ko:K12506 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R00597,R05633,R05637 RC00002,RC00003,RC00334,RC01440 ko00000,ko00001,ko00002,ko01000,ko03016 iNJ661.Rv3581c,iPC815.YPO3360 Bacteria 3J0N6@40117,COG0245@1,COG0245@2 NA|NA|NA H Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) MAG.T1.5_02829 330214.NIDE2977 1.2e-110 406.0 Nitrospirae ispD GO:0000166,GO:0000287,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016114,GO:0016740,GO:0016772,GO:0016779,GO:0019103,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044464,GO:0046490,GO:0046872,GO:0046914,GO:0050518,GO:0051483,GO:0051484,GO:0070567,GO:0071704,GO:0071944,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.405,2.7.7.40,2.7.7.60,4.6.1.12 ko:K00991,ko:K12506,ko:K21030,ko:K21681 ko00040,ko00900,ko01100,ko01110,ko01130,map00040,map00900,map01100,map01110,map01130 M00096 R01525,R02921,R05633,R05637 RC00002,RC00089,RC01440 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS20335 Bacteria 3J18C@40117,COG1211@1,COG1211@2 NA|NA|NA I 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase MAG.T1.5_02830 330214.NIDE2978 3.7e-169 600.9 Nitrospirae yacL GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 Bacteria 3J0G5@40117,COG4956@1,COG4956@2 NA|NA|NA S Large family of predicted nucleotide-binding domains MAG.T1.5_02831 330214.NIDE2979 9.4e-265 919.1 Nitrospirae htrA GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 Bacteria 3J0X9@40117,COG0265@1,COG0265@2 NA|NA|NA M Evidence 2a Function of homologous gene experimentally demonstrated in an other organism MAG.T1.5_02832 330214.NIDE2980 2.6e-161 574.7 Nitrospirae fbaB 4.1.2.13 ko:K11645 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 Bacteria 3J1DE@40117,COG1830@1,COG1830@2 NA|NA|NA G DeoC/LacD family aldolase MAG.T1.5_02833 330214.NIDE2981 1.7e-150 538.9 Nitrospirae fbp GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005985,GO:0005986,GO:0005996,GO:0006000,GO:0006002,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016043,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0022607,GO:0030388,GO:0034637,GO:0042132,GO:0042578,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046364,GO:0050308,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901135,GO:1901576 3.1.3.11 ko:K03841 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910 M00003,M00165,M00167,M00344 R00762,R04780 RC00017 ko00000,ko00001,ko00002,ko01000,ko04147 iUTI89_1310.UTI89_C4836,ic_1306.c5329 Bacteria 3J12X@40117,COG0158@1,COG0158@2 NA|NA|NA G Fructose-1-6-bisphosphatase, N-terminal domain MAG.T1.5_02834 330214.NIDE2982 3.4e-112 411.4 Nitrospirae Bacteria 3J1DA@40117,COG3170@1,COG3170@2 NA|NA|NA NU Protein of unknown function (DUF3108) MAG.T1.5_02835 330214.NIDE2983 1.9e-245 854.7 Nitrospirae algC GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 5.4.2.2,5.4.2.8 ko:K01835,ko:K01840,ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114,M00549 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0AF@40117,COG1109@1,COG1109@2 NA|NA|NA G Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III MAG.T1.5_02836 330214.NIDE2984 6.5e-252 876.3 Nitrospirae manC 2.7.7.13,5.3.1.8,5.4.2.8 ko:K00971,ko:K01840,ko:K16011 ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025 M00114,M00361,M00362 R00885,R01818,R01819 RC00002,RC00376,RC00408 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS00940 Bacteria 3J0FF@40117,COG0662@1,COG0662@2,COG0836@1,COG0836@2 NA|NA|NA GM Belongs to the mannose-6-phosphate isomerase type 2 family MAG.T1.5_02837 330214.NIDE2985 1.1e-69 269.6 Nitrospirae kdsC GO:0003674,GO:0003824,GO:0008781,GO:0016740,GO:0016772,GO:0016779,GO:0070567 2.5.1.55,2.7.7.43,2.7.7.92,3.1.3.103,3.1.3.45 ko:K01627,ko:K03270,ko:K21055,ko:K21749 ko00520,ko00540,ko01100,map00520,map00540,map01100 M00063 R01117,R03254,R03350,R04215,R11440 RC00017,RC00152,RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 Bacteria 3J1EJ@40117,COG1778@1,COG1778@2 NA|NA|NA S Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate MAG.T1.5_02838 330214.NIDE2986 1.9e-253 881.3 Bacteria wcaJ ko:K03606,ko:K20997 ko02025,ko05111,map02025,map05111 ko00000,ko00001 Bacteria COG1086@1,COG1086@2,COG2148@1,COG2148@2 NA|NA|NA GM Polysaccharide biosynthesis protein MAG.T1.5_02839 330214.NIDE2987 5.2e-183 647.1 Bacteria wcnD Bacteria COG0438@1,COG0438@2 NA|NA|NA M transferase activity, transferring glycosyl groups MAG.T1.5_02841 237368.SCABRO_00136 2.6e-31 144.4 Planctomycetes Bacteria 2IZ4U@203682,COG0438@1,COG0438@2 NA|NA|NA M glycosyl transferase group 1 MAG.T1.5_02842 1321781.HMPREF1985_01945 2e-92 346.3 Firmicutes Bacteria 1V4WG@1239,COG0438@1,COG0438@2 NA|NA|NA M Glycosyltransferase, group 1 family protein MAG.T1.5_02843 330214.NIDE2989 1.6e-115 422.9 Bacteria Bacteria COG0438@1,COG0438@2 NA|NA|NA M transferase activity, transferring glycosyl groups MAG.T1.5_02844 330214.NIDE2990 6.3e-95 354.0 Bacteria Bacteria COG0500@1,COG2226@2 NA|NA|NA Q methyltransferase MAG.T1.5_02845 330214.NIDE2991 2e-159 568.9 Bacteria Bacteria COG0438@1,COG0438@2 NA|NA|NA M transferase activity, transferring glycosyl groups MAG.T1.5_02846 330214.NIDE2992 2.9e-87 328.6 Bacteria cypM_1 2.1.1.222,2.1.1.64 ko:K00568 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04988,R05614,R08769,R08781 RC00003,RC00392,RC01895 ko00000,ko00001,ko00002,ko01000 Bacteria COG2227@1,COG2227@2 NA|NA|NA H 3-demethylubiquinone-9 3-O-methyltransferase activity MAG.T1.5_02847 330214.NIDE2993 1e-197 696.0 Nitrospirae Bacteria 3J0X1@40117,COG0438@1,COG0438@2 NA|NA|NA M Glycosyl transferase, group 1 MAG.T1.5_02848 925409.KI911562_gene150 1.6e-71 276.6 Bacteroidetes Bacteria 4NNQC@976,COG2227@1,COG2227@2 NA|NA|NA H Methyltransferase domain MAG.T1.5_02849 330214.NIDE2995 1.9e-299 1034.6 Nitrospirae 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 R00578 RC00010 ko00000,ko00001,ko01000,ko01002 Bacteria 3J0XS@40117,COG0367@1,COG0367@2 NA|NA|NA F Asparagine synthase MAG.T1.5_02850 330214.NIDE2996 3.3e-217 761.1 Nitrospirae Bacteria 3J0ZX@40117,COG0438@1,COG0438@2 NA|NA|NA M transferase activity, transferring glycosyl groups MAG.T1.5_02851 330214.NIDE2997 3.9e-179 634.0 Bacteria 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 Bacteria COG0451@1,COG0451@2 NA|NA|NA GM ADP-glyceromanno-heptose 6-epimerase activity MAG.T1.5_02852 330214.NIDE2998 8.9e-196 689.5 Nitrospirae neuC GO:0003674,GO:0003824,GO:0004553,GO:0005975,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016787,GO:0016798,GO:0044238,GO:0071704,GO:1901576 3.2.1.184,5.1.3.14 ko:K01791,ko:K18429 ko00520,ko01100,ko05111,map00520,map01100,map05111 M00362 R00420,R10187 RC00005,RC00288,RC00290 ko00000,ko00001,ko00002,ko01000,ko01005 Bacteria 3J0Y8@40117,COG0381@1,COG0381@2 NA|NA|NA M UDP-N-acetylglucosamine 2-epimerase MAG.T1.5_02853 330214.NIDE2999 2.1e-191 674.9 Nitrospirae neuB 2.5.1.56,3.2.1.183 ko:K01654,ko:K08068 ko00520,ko01100,map00520,map01100 R01804,R04435 RC00159 ko00000,ko00001,ko01000 Bacteria 3J0XF@40117,COG2089@1,COG2089@2 NA|NA|NA M SAF MAG.T1.5_02854 330214.NIDE3000 1.2e-99 369.4 Nitrospirae neuA 2.7.7.43,2.7.7.92 ko:K00983,ko:K21749 ko00520,ko01100,map00520,map01100 R01117,R04215 RC00152 ko00000,ko00001,ko01000 Bacteria 3J12Z@40117,COG1083@1,COG1083@2 NA|NA|NA H Cytidylyltransferase MAG.T1.5_02856 1173264.KI913949_gene1853 2.6e-06 60.1 Oscillatoriales Bacteria 1FZXE@1117,1H927@1150,COG3321@1,COG3321@2 NA|NA|NA Q Acyl transferase domain in polyketide synthase (PKS) enzymes. MAG.T1.5_02857 289376.THEYE_A0478 1.4e-91 343.6 Nitrospirae Bacteria 3J18P@40117,COG0438@1,COG0438@2 NA|NA|NA M Glycosyl transferases group 1 MAG.T1.5_02858 289376.THEYE_A0473 1.2e-117 429.9 Bacteria 5.1.3.10,5.1.3.2 ko:K01784,ko:K12454 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984,R04266 RC00289,RC00528 ko00000,ko00001,ko00002,ko01000 Bacteria COG0451@1,COG0451@2 NA|NA|NA GM ADP-glyceromanno-heptose 6-epimerase activity MAG.T1.5_02859 330214.NIDE3007 2.4e-190 671.8 Nitrospirae Bacteria 3J0XB@40117,COG2244@1,COG2244@2 NA|NA|NA S Polysaccharide biosynthesis protein MAG.T1.5_02860 330214.NIDE3008 1.7e-83 315.5 Nitrospirae cysC GO:0000096,GO:0000103,GO:0003674,GO:0003824,GO:0004020,GO:0004779,GO:0004781,GO:0006082,GO:0006520,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010134,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0019379,GO:0019419,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0055114,GO:0070566,GO:0071704,GO:1901564 1.8.4.10,1.8.4.8,2.7.1.25,2.7.7.4 ko:K00390,ko:K00860,ko:K00955,ko:K00958,ko:K13811 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00509,R00529,R02021,R04928,R04929 RC00002,RC00007,RC00078,RC02809,RC02862,RC02889 ko00000,ko00001,ko00002,ko01000 Bacteria 3J141@40117,COG0529@1,COG0529@2 NA|NA|NA F Catalyzes the synthesis of activated sulfate MAG.T1.5_02861 330214.NIDE3009 2.1e-259 901.7 Bacteria Bacteria COG5360@1,COG5360@2 NA|NA|NA S Heparinase II/III-like protein MAG.T1.5_02862 330214.NIDE3010 0.0 1095.1 Bacteria 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 R00578 RC00010 ko00000,ko00001,ko01000,ko01002 Bacteria COG0367@1,COG0367@2 NA|NA|NA E asparagine synthase MAG.T1.5_02863 330214.NIDE3011 1.4e-151 542.3 Nitrospirae fcl 1.1.1.271 ko:K02377,ko:K16554 ko00051,ko00520,ko01100,ko05111,map00051,map00520,map01100,map05111 R05692 RC01014 ko00000,ko00001,ko01000,ko02000 8.A.3.1 Bacteria 3J0XH@40117,COG0451@1,COG0451@2 NA|NA|NA GM Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction MAG.T1.5_02864 330214.NIDE3012 2.1e-177 628.2 Nitrospirae gmd 4.2.1.47 ko:K01711 ko00051,ko00520,ko01100,map00051,map00520,map01100 R00888 RC00402 ko00000,ko00001,ko01000 Bacteria 3J0YR@40117,COG1089@1,COG1089@2 NA|NA|NA M Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose MAG.T1.5_02865 330214.NIDE3013 4.7e-150 537.7 Bacteria ko:K02847,ko:K02849,ko:K21003 ko00540,ko01100,ko02025,map00540,map01100,map02025 M00080 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005,ko02000 9.B.67.4,9.B.67.5 GT9 Bacteria COG3307@1,COG3307@2 NA|NA|NA M -O-antigen MAG.T1.5_02866 330214.NIDE3014 3.5e-136 491.1 Nitrospirae rmlD 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0SU@40117,COG1091@1,COG1091@2 NA|NA|NA M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose MAG.T1.5_02867 330214.NIDE3015 2.8e-180 637.9 Nitrospirae rfbB GO:0000166,GO:0000271,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008460,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019305,GO:0019438,GO:0030312,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044464,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0048037,GO:0050662,GO:0051287,GO:0055086,GO:0070404,GO:0071704,GO:0071944,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 4.2.1.46,4.2.1.76 ko:K01710,ko:K12450 ko00520,ko00521,ko00523,ko00525,ko01055,ko01130,map00520,map00521,map00523,map00525,map01055,map01130 M00793 R00293,R06513 RC00402 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv3464 Bacteria 3J0CT@40117,COG1088@1,COG1088@2 NA|NA|NA M Male sterility protein MAG.T1.5_02868 330214.NIDE3016 5.4e-130 470.3 Nitrospirae spsI 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0KX@40117,COG1209@1,COG1209@2 NA|NA|NA M Nucleotidyl transferase MAG.T1.5_02869 330214.NIDE3019 3.3e-160 571.2 Nitrospirae wbdA2 ko:K00786 ko00000,ko01000 Bacteria 3J19R@40117,COG0438@1,COG0438@2 NA|NA|NA M Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_02870 330214.NIDE3020 2.3e-154 551.6 Nitrospirae Bacteria 3J1DN@40117,COG1216@1,COG1216@2 NA|NA|NA S Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_02871 330214.NIDE3021 5.4e-176 623.6 Bacteria crtF Bacteria COG0500@1,COG2226@2 NA|NA|NA Q methyltransferase MAG.T1.5_02872 330214.NIDE3022 7.8e-155 553.1 Nitrospirae Bacteria 3J1DN@40117,COG1216@1,COG1216@2 NA|NA|NA S Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_02873 330214.NIDE3023 2.5e-160 571.6 Nitrospirae rfaQ ko:K02841,ko:K02843,ko:K02849 ko00540,ko01100,map00540,map01100 M00080 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 GT9 Bacteria 3J161@40117,COG0859@1,COG0859@2 NA|NA|NA M Glycosyltransferase family 9 (heptosyltransferase) MAG.T1.5_02874 330214.NIDE3025 4.3e-163 580.9 Nitrospirae Bacteria 3J19R@40117,COG0438@1,COG0438@2 NA|NA|NA M Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_02875 330214.NIDE3026 3.4e-127 461.1 Nitrospirae kdtX ko:K12984 ko00000,ko01000,ko01003,ko01005,ko02000 4.D.1.3 GT2 Bacteria 3J0M5@40117,COG0463@1,COG0463@2 NA|NA|NA M biosynthesis glycosyltransferase MAG.T1.5_02876 330214.NIDE3027 3.6e-137 494.2 Nitrospirae kdtX ko:K12984 ko00000,ko01000,ko01003,ko01005,ko02000 4.D.1.3 GT2 Bacteria 3J0M5@40117,COG0463@1,COG0463@2 NA|NA|NA M biosynthesis glycosyltransferase MAG.T1.5_02877 330214.NIDE3028 0.0 1090.5 Bacteria ltaS2 2.7.8.20 ko:K01002,ko:K01138 ko01100,map01100 ko00000,ko01000 Bacteria COG1368@1,COG1368@2 NA|NA|NA M sulfuric ester hydrolase activity MAG.T1.5_02878 330214.NIDE3029 4.8e-167 594.0 Nitrospirae ko:K00754 ko00000,ko01000 GT4 Bacteria 3J129@40117,COG0438@1,COG0438@2 NA|NA|NA M Glycosyl transferase 4-like domain MAG.T1.5_02879 330214.NIDE3030 1e-156 559.7 Nitrospirae ko:K02841,ko:K02843,ko:K02849,ko:K12982 ko00540,ko01100,map00540,map01100 M00080 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 GT9 Bacteria 3J0KI@40117,COG0859@1,COG0859@2 NA|NA|NA M Glycosyltransferase family 9 (heptosyltransferase) MAG.T1.5_02880 330214.NIDE3031 9.5e-287 992.3 Nitrospirae rfaF 2.7.1.167,2.7.7.70,3.1.3.82,3.1.3.83,5.3.1.28 ko:K02843,ko:K02849,ko:K03271,ko:K03272,ko:K03273 ko00540,ko01100,map00540,map01100 M00064,M00080 R05644,R05645,R05646,R05647,R09768,R09769,R09771 RC00002,RC00017,RC00078,RC00434 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 GT9 Bacteria 3J0PZ@40117,COG0241@1,COG0241@2,COG0859@1,COG0859@2 NA|NA|NA EM Glycosyltransferase family 9 (heptosyltransferase) MAG.T1.5_02881 330214.NIDE3032 1.1e-147 529.6 Nitrospirae lpxK GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008654,GO:0009029,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019637,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046401,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.7.1.130 ko:K00912 ko00540,ko01100,map00540,map01100 M00060 R04657 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 iBWG_1329.BWG_0767,iECDH10B_1368.ECDH10B_0985,iPC815.YPO1396 Bacteria 3J0QN@40117,COG1663@1,COG1663@2 NA|NA|NA M Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) MAG.T1.5_02882 330214.NIDE3033 9e-187 659.8 Nitrospirae kdtA GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 GT30 iECNA114_1301.ECNA114_3778,iIT341.HP0957,iUMNK88_1353.UMNK88_4417 Bacteria 3J0J7@40117,COG1519@1,COG1519@2 NA|NA|NA M 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) MAG.T1.5_02883 330214.NIDE3034 3.1e-15 87.4 Bacteria MA20_05800 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527,ko:K09778 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 GT30 Bacteria COG2121@1,COG2121@2 NA|NA|NA S Domain of unknown function (DUF374) MAG.T1.5_02884 330214.NIDE3036 4.8e-294 1016.5 Nitrospirae msbA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0006869,GO:0008144,GO:0008150,GO:0008289,GO:0008559,GO:0009987,GO:0010876,GO:0015221,GO:0015238,GO:0015399,GO:0015405,GO:0015437,GO:0015893,GO:0015920,GO:0016020,GO:0016021,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0034040,GO:0034204,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042802,GO:0042908,GO:0042910,GO:0043167,GO:0043168,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0065007,GO:0065008,GO:0071702,GO:0071840,GO:0071944,GO:0097035,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901265,GO:1901363,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 ko:K02021,ko:K06147,ko:K11085 ko02010,map02010 ko00000,ko00001,ko01000,ko02000 3.A.1.106,3.A.1.109,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21 iJN746.PP_4935,iPC815.YPO1395,iUMN146_1321.UM146_12980 Bacteria 3J0X8@40117,COG1132@1,COG1132@2 NA|NA|NA V Evidence 2a Function of homologous gene experimentally demonstrated in an other organism MAG.T1.5_02885 330214.NIDE3037 1.5e-187 662.1 Nitrospirae lpxB GO:0003674,GO:0003824,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008194,GO:0008289,GO:0008610,GO:0008654,GO:0008915,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0019897,GO:0019898,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 GT19 iE2348C_1286.E2348C_0187,iEcolC_1368.EcolC_3478,iIT341.HP0867 Bacteria 3J0MA@40117,COG0763@1,COG0763@2 NA|NA|NA M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell MAG.T1.5_02886 330214.NIDE3038 2e-151 542.0 Nitrospirae gnnA ko:K09949 ko00000 iAF987.Gmet_2352 Bacteria 3J0M7@40117,COG0673@1,COG0673@2 NA|NA|NA S Oxidoreductase family, NAD-binding Rossmann fold MAG.T1.5_02887 330214.NIDE3039 6.2e-138 496.9 Nitrospirae cdsA2 GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008758,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 ko:K00748,ko:K09949 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 GT19 Bacteria 3J0KP@40117,COG3494@1,COG3494@2 NA|NA|NA S Protein of unknown function (DUF1009) MAG.T1.5_02888 330214.NIDE3040 5.8e-117 427.2 Nitrospirae lpxA GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0008780,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 iIT341.HP1375,iPC815.YPO1056 Bacteria 3J0G6@40117,COG1043@1,COG1043@2 NA|NA|NA M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell MAG.T1.5_02889 330214.NIDE3041 3.1e-75 287.7 Nitrospirae fabZ GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0019171 3.5.1.108,4.2.1.59 ko:K02372,ko:K16363 ko00061,ko00540,ko00780,ko01100,ko01212,map00061,map00540,map00780,map01100,map01212 M00060,M00083,M00572 R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965,R07764,R10117,R10121 RC00166,RC00300,RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004,ko01005 Bacteria 3J0NG@40117,COG0764@1,COG0764@2 NA|NA|NA I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs MAG.T1.5_02890 330214.NIDE3042 6.9e-66 256.9 Nitrospirae ompH ko:K06142 ko00000 Bacteria 3J1AH@40117,COG2825@1,COG2825@2 NA|NA|NA M Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_02891 330214.NIDE3043 4.3e-58 231.1 Nitrospirae ompH ko:K06142 ko00000 Bacteria 3J1AH@40117,COG2825@1,COG2825@2 NA|NA|NA M Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_02892 330214.NIDE3044 0.0 1457.6 Nitrospirae bamA GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 ko:K07277 ko00000,ko02000,ko03029 1.B.33 Bacteria 3J0AC@40117,COG4775@1,COG4775@2 NA|NA|NA M Surface antigen MAG.T1.5_02893 996637.SGM_6017 9.3e-27 127.9 Actinobacteria fthC 6.3.3.2 ko:K01934 ko00670,ko01100,map00670,map01100 R02301 RC00183 ko00000,ko00001,ko01000 Bacteria 2IKWR@201174,COG0212@1,COG0212@2 NA|NA|NA H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family MAG.T1.5_02894 330214.NIDE3046 0.0 1474.1 Nitrospirae lon 3.4.21.53 ko:K01338 ko04112,map04112 ko00000,ko00001,ko01000,ko01002 Bacteria 3J0DQ@40117,COG0466@1,COG0466@2 NA|NA|NA O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner MAG.T1.5_02895 330214.NIDE3047 1.4e-145 522.7 Nitrospirae thiL 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 iYO844.BSU05900 Bacteria 3J0TF@40117,COG0611@1,COG0611@2 NA|NA|NA H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 MAG.T1.5_02896 330214.NIDE3048 6.8e-73 280.0 Nitrospirae ko:K09928 ko00000 Bacteria 3J1DC@40117,COG3216@1,COG3216@2 NA|NA|NA S Uncharacterized protein conserved in bacteria (DUF2062) MAG.T1.5_02897 330214.NIDE3049 6.3e-260 902.9 Nitrospirae ko:K06885 ko00000 Bacteria 3J0YB@40117,COG1078@1,COG1078@2 NA|NA|NA S Metal dependent phosphohydrolases with conserved 'HD' motif. MAG.T1.5_02898 330214.NIDE3050 0.0 1248.8 Bacteria 3.1.3.3 ko:K07315 ko00000,ko01000,ko03021 Bacteria COG2202@1,COG2202@2,COG3829@1,COG3829@2,COG4251@1,COG4251@2 NA|NA|NA T Pas domain MAG.T1.5_02899 298653.Franean1_6521 1.1e-34 152.9 Actinobacteria Bacteria 2I2VM@201174,COG0745@1,COG0745@2 NA|NA|NA T Response regulator receiver MAG.T1.5_02900 330214.NIDE3052 0.0 1197.2 Nitrospirae MA20_35885 Bacteria 3J10H@40117,COG0745@1,COG0745@2,COG0784@1,COG0784@2,COG2202@1,COG2202@2,COG2203@1,COG2203@2,COG4191@1,COG4191@2 NA|NA|NA T Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_02901 330214.NIDE3053 6.3e-158 563.5 Nitrospirae 3.4.24.75 ko:K08259 ko00000,ko01000,ko01002,ko01011 Bacteria 3J16B@40117,COG0739@1,COG0739@2 NA|NA|NA M Peptidase family M23 MAG.T1.5_02902 330214.NIDE3054 1.3e-262 911.8 Bacteria pafA GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170 6.3.1.19 ko:K13571 M00342 R11207 RC00090,RC00096 ko00000,ko00002,ko01000,ko03051 Bacteria COG0638@1,COG0638@2 NA|NA|NA O Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine MAG.T1.5_02903 330214.NIDE3055 2.9e-117 427.9 Bacteria 3.4.25.1 ko:K03432 ko03050,map03050 M00342,M00343 ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 Bacteria COG0638@1,COG0638@2 NA|NA|NA O Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine MAG.T1.5_02904 330214.NIDE3056 1.2e-133 482.6 Bacteria prcB GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019774,GO:0019899,GO:0019941,GO:0030163,GO:0032991,GO:0035375,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 ko:K03433 ko03050,map03050 M00342,M00343 ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 Bacteria COG0638@1,COG0638@2 NA|NA|NA O Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine MAG.T1.5_02905 330214.NIDE3057 1.9e-270 937.9 Bacteria dop GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.5.1.119,6.3.1.19 ko:K13571,ko:K20814 M00342 R11207 RC00090,RC00096 ko00000,ko00002,ko01000,ko03051 Bacteria COG4122@1,COG4122@2 NA|NA|NA E O-methyltransferase activity MAG.T1.5_02906 330214.NIDE3058 0.0 1112.4 Bacteria arc GO:0000302,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0010499,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0019941,GO:0022623,GO:0022624,GO:0030163,GO:0030312,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042802,GO:0043170,GO:0043335,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044877,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070628,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097366,GO:0140030,GO:0140035,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1902494,GO:1905368,GO:1905369 ko:K13527 ko03050,map03050 M00342 ko00000,ko00001,ko00002,ko03051 Bacteria COG1222@1,COG1222@2 NA|NA|NA O protein catabolic process MAG.T1.5_02907 330214.NIDE3059 9.8e-64 250.0 Nitrospirae thiE GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0QS@40117,COG0352@1,COG0352@2 NA|NA|NA H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) MAG.T1.5_02908 330214.NIDE3060 2e-135 488.4 Nitrospirae thiG GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.10 ko:K03149 ko00730,ko01100,map00730,map01100 R10247 RC03096,RC03097,RC03461 ko00000,ko00001,ko01000 Bacteria 3J0EI@40117,COG2022@1,COG2022@2 NA|NA|NA H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S MAG.T1.5_02909 330214.NIDE3061 7.2e-24 115.9 Nitrospirae thiS ko:K03154 ko04122,map04122 ko00000,ko00001 Bacteria 3J1CM@40117,COG2104@1,COG2104@2 NA|NA|NA H ThiS family MAG.T1.5_02910 330214.NIDE3063 8e-61 240.0 Bacteria dpbF 3.1.11.5 ko:K02347,ko:K03581,ko:K04477 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria COG1796@1,COG1796@2 NA|NA|NA L DNA-directed DNA polymerase activity MAG.T1.5_02911 330214.NIDE3064 2.1e-233 814.7 Nitrospirae ctpA 3.4.21.102 ko:K03797 ko00000,ko01000,ko01002 Bacteria 3J09Y@40117,COG0793@1,COG0793@2 NA|NA|NA M tail specific protease MAG.T1.5_02912 330214.NIDE3065 9e-191 672.9 Nitrospirae envC GO:0000920,GO:0001896,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008219,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0012501,GO:0016020,GO:0016787,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0042546,GO:0042597,GO:0043085,GO:0044085,GO:0044093,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071554,GO:0071840,GO:0071944 ko:K21471 ko00000,ko01000,ko01002,ko01011 Bacteria 3J0SP@40117,COG4942@1,COG4942@2 NA|NA|NA D Peptidase family M23 MAG.T1.5_02913 330214.NIDE3066 1.3e-130 472.6 Nitrospirae ftsX GO:0005575,GO:0005618,GO:0005623,GO:0006928,GO:0008150,GO:0009274,GO:0009276,GO:0009605,GO:0009607,GO:0009615,GO:0009987,GO:0030312,GO:0030313,GO:0031975,GO:0040011,GO:0043207,GO:0044464,GO:0048870,GO:0050896,GO:0051179,GO:0051301,GO:0051674,GO:0051704,GO:0051707,GO:0071944,GO:0071976 ko:K09811,ko:K09812 ko02010,map02010 M00256 ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 Bacteria 3J18Q@40117,COG2177@1,COG2177@2 NA|NA|NA D Belongs to the ABC-4 integral membrane protein family. FtsX subfamily MAG.T1.5_02914 330214.NIDE3067 1.5e-107 395.6 Nitrospirae ftsE GO:0000166,GO:0000287,GO:0000910,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0007049,GO:0008144,GO:0008150,GO:0008356,GO:0009898,GO:0009966,GO:0009987,GO:0010646,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019897,GO:0019898,GO:0022402,GO:0022603,GO:0022607,GO:0023051,GO:0030145,GO:0030554,GO:0031234,GO:0032153,GO:0032506,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042173,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043937,GO:0043938,GO:0044085,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0046677,GO:0046872,GO:0046914,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051301,GO:0065007,GO:0070297,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363,GO:1902531 ko:K09811,ko:K09812 ko02010,map02010 M00256 ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 Bacteria 3J139@40117,COG2884@1,COG2884@2 NA|NA|NA D ABC transporter MAG.T1.5_02915 330214.NIDE3068 1.2e-51 209.1 Nitrospirae yraN ko:K07460 ko00000 Bacteria 3J1ER@40117,COG0792@1,COG0792@2 NA|NA|NA L Uncharacterised protein family UPF0102 MAG.T1.5_02916 330214.NIDE3069 4e-95 354.4 Nitrospirae rnhB GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 ko:K03470 ko03030,map03030 ko00000,ko00001,ko01000,ko03032 Bacteria 3J0P5@40117,COG0164@1,COG0164@2 NA|NA|NA L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids MAG.T1.5_02917 330214.NIDE3070 4.3e-60 237.3 Nitrospirae rplS GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02884 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0MJ@40117,COG0335@1,COG0335@2 NA|NA|NA J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site MAG.T1.5_02918 330214.NIDE3071 6.5e-134 483.4 Nitrospirae trmD GO:0000287,GO:0001510,GO:0002939,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050518,GO:0052906,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228,4.6.1.12 ko:K00554,ko:K01770 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R00597,R05637 RC00002,RC00003,RC00334,RC01440 ko00000,ko00001,ko00002,ko01000,ko03016 Bacteria 3J0JN@40117,COG0336@1,COG0336@2 NA|NA|NA J Belongs to the RNA methyltransferase TrmD family MAG.T1.5_02919 330214.NIDE3072 1.1e-73 282.7 Bacteria rimM GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 ko:K02860 ko00000,ko03009 Bacteria COG0806@1,COG0806@2 NA|NA|NA J ribosome binding MAG.T1.5_02920 330214.NIDE3073 4e-42 177.2 Nitrospirae rpsP GO:0000028,GO:0000217,GO:0000400,GO:0003674,GO:0003676,GO:0003677,GO:0003735,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006259,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016787,GO:0016788,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02959 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011,ko03029 Bacteria 3J0UI@40117,COG0228@1,COG0228@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bS16 family MAG.T1.5_02921 330214.NIDE3074 4.1e-240 837.0 Nitrospirae ffh GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006605,GO:0006612,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0030312,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0040007,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046907,GO:0048500,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0071944,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1990904 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 Bacteria 3J0DT@40117,COG0541@1,COG0541@2 NA|NA|NA U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY MAG.T1.5_02922 330214.NIDE3076 2.1e-36 157.9 Nitrospirae Bacteria 29W29@1,30HKU@2,3J1EN@40117 NA|NA|NA S Domain of unknown function (DUF4321) MAG.T1.5_02923 330214.NIDE3077 0.0 1244.6 Nitrospirae uvrB GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009314,GO:0009380,GO:0009628,GO:0032991,GO:0042802,GO:0044424,GO:0044464,GO:0050896,GO:1902494,GO:1905347,GO:1905348,GO:1990391 ko:K03702,ko:K08999 ko03420,map03420 ko00000,ko00001,ko03400 Bacteria 3J0FS@40117,COG0556@1,COG0556@2 NA|NA|NA L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage MAG.T1.5_02924 330214.NIDE3235 3.2e-73 281.6 Bacteria 3.1.3.3,4.6.1.1 ko:K01768,ko:K07315 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000,ko03021 Bacteria COG5278@1,COG5278@2 NA|NA|NA T phosphoserine phosphatase activity MAG.T1.5_02925 330214.NIDE3236 1.6e-265 921.4 Nitrospirae narH GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.7.5.1 ko:K00371,ko:K16965,ko:K17048,ko:K17051 ko00642,ko00910,ko00920,ko01100,ko01120,ko01220,ko02020,map00642,map00910,map00920,map01100,map01120,map01220,map02020 M00529,M00530,M00804 R00798,R01106,R05745,R09497,R09500 RC00275,RC02555,RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.8,5.A.3.9 Bacteria 3J1FU@40117,COG1140@1,COG1140@2 NA|NA|NA C Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_02926 330214.NIDE3255 1.4e-143 515.4 Bacteria ddhA GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.17.99.2,1.7.5.1,1.8.2.4 ko:K00370,ko:K10700,ko:K16964,ko:K17050 ko00642,ko00910,ko00920,ko01100,ko01120,ko01220,ko02020,map00642,map00910,map00920,map01100,map01120,map01220,map02020 M00529,M00530,M00804 R00798,R01106,R05745,R09497,R09500 RC00275,RC02555,RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.8,5.A.3.9 Bacteria COG0243@1,COG0243@2 NA|NA|NA C molybdopterin cofactor binding MAG.T1.5_02928 330214.NIDE2901 6.7e-18 97.8 Bacteria Bacteria COG2197@1,COG2197@2 NA|NA|NA K response regulator MAG.T1.5_02929 1499967.BAYZ01000003_gene5836 1e-11 77.4 Bacteria ko:K06985 ko04112,map04112 ko00000,ko00001 Bacteria COG0457@1,COG0457@2,COG3577@1,COG3577@2 NA|NA|NA S aspartic-type endopeptidase activity MAG.T1.5_02930 883078.HMPREF9695_04745 1.1e-170 606.3 Bradyrhizobiaceae hipA 2.7.11.1 ko:K07154 ko00000,ko01000,ko01001,ko02048 Bacteria 1MVAB@1224,2U1TN@28211,3JWF0@41294,COG3550@1,COG3550@2 NA|NA|NA S HipA N-terminal domain MAG.T1.5_02931 187272.Mlg_2300 1.9e-26 124.8 Proteobacteria ko:K15773 ko00000,ko02048,ko03000 Bacteria 1QWRC@1224,COG1476@1,COG1476@2 NA|NA|NA K Helix-turn-helix domain MAG.T1.5_02932 926566.Terro_3115 5.3e-09 69.3 Bacteria repA Bacteria COG5534@1,COG5534@2 NA|NA|NA L Replication initiator protein MAG.T1.5_02933 555079.Toce_2277 6.8e-31 141.7 Thermoanaerobacterales noc ko:K03497 ko00000,ko03000,ko03036,ko04812 Bacteria 1TP0I@1239,2488X@186801,42F6H@68295,COG1475@1,COG1475@2 NA|NA|NA K Belongs to the ParB family MAG.T1.5_02934 981327.F925_00156 7.6e-43 181.0 Moraxellaceae ko:K03496 ko00000,ko03036,ko04812 Bacteria 1NAJP@1224,1S4V1@1236,3NMK3@468,COG1192@1,COG1192@2 NA|NA|NA D Cellulose biosynthesis protein BcsQ MAG.T1.5_02936 926692.AZYG01000026_gene1759 5.9e-20 105.5 Firmicutes xerC ko:K03733,ko:K04763 ko00000,ko03036 Bacteria 1V98H@1239,COG4974@1,COG4974@2 NA|NA|NA L Belongs to the 'phage' integrase family MAG.T1.5_02938 673862.BABL1_818 6e-22 111.7 Proteobacteria xerC ko:K03733,ko:K04763 ko00000,ko03036 Bacteria 1R43B@1224,COG4974@1,COG4974@2 NA|NA|NA L Belongs to the 'phage' integrase family MAG.T1.5_02939 349521.HCH_06284 2.4e-41 175.6 Gammaproteobacteria Bacteria 1N3EJ@1224,1SDTB@1236,2E1F4@1,32WTW@2 NA|NA|NA MAG.T1.5_02940 1157708.KB907466_gene609 7.2e-126 457.2 Comamonadaceae spiA ko:K18831 ko00000,ko02048,ko03000 Bacteria 1NEHF@1224,2VNNV@28216,4AGJ8@80864,COG1476@1,COG1476@2,COG2856@1,COG2856@2 NA|NA|NA EK Pfam:DUF955 MAG.T1.5_02941 215803.DB30_8177 1e-11 79.3 Myxococcales Bacteria 1MXU2@1224,2WY5D@28221,2YVNQ@29,433F4@68525,COG0846@1,COG0846@2 NA|NA|NA K SIR2-like domain MAG.T1.5_02942 1502852.FG94_02737 1.1e-22 114.8 Oxalobacteraceae Bacteria 1NVVK@1224,2DSAI@1,2W2GZ@28216,33F8S@2,47605@75682 NA|NA|NA MAG.T1.5_02943 1403313.AXBR01000005_gene1686 2e-71 276.2 Bacillus 3.6.1.3 ko:K07132 ko00000,ko01000 Bacteria 1TT81@1239,1ZF9U@1386,4HCMF@91061,COG2842@1,COG2842@2 NA|NA|NA S AAA domain MAG.T1.5_02944 1403313.AXBR01000005_gene1687 6.4e-138 498.0 Bacillus ko:K07497 ko00000 Bacteria 1TRP2@1239,1ZCA5@1386,4HEKP@91061,COG2801@1,COG2801@2 NA|NA|NA L Transposase and inactivated derivatives MAG.T1.5_02945 1408254.T458_00060 7.2e-25 121.3 Paenibacillaceae Bacteria 1VR0F@1239,26ZTS@186822,2EHE4@1,33B60@2,4HVD9@91061 NA|NA|NA MAG.T1.5_02948 240015.ACP_1543 6.8e-43 181.0 Bacteria Bacteria COG2856@1,COG2856@2 NA|NA|NA E Zn peptidase MAG.T1.5_02949 1121447.JONL01000003_gene3168 1e-11 77.4 Proteobacteria Bacteria 1NXAH@1224,COG3012@1,COG3012@2 NA|NA|NA S SEC-C Motif Domain Protein MAG.T1.5_02950 1216007.AOPM01000027_gene3589 4.7e-99 368.2 Gammaproteobacteria Bacteria 1R655@1224,1S76V@1236,2DBDI@1,2Z8M4@2 NA|NA|NA MAG.T1.5_02951 96561.Dole_2088 4.9e-128 464.5 Proteobacteria 2.3.1.51 ko:K00655,ko:K07451 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004,ko02048 Bacteria 1PAQC@1224,COG1403@1,COG1403@2 NA|NA|NA V HNH endonuclease MAG.T1.5_02952 1122915.AUGY01000041_gene823 7.7e-46 189.9 Bacteria Bacteria 2BWTI@1,32SZZ@2 NA|NA|NA MAG.T1.5_02953 1122915.AUGY01000041_gene822 1.3e-154 552.7 Bacteria 2.7.7.80 ko:K21029 ko04122,map04122 R07459 RC00043 ko00000,ko00001,ko01000 Bacteria COG0476@1,COG0476@2 NA|NA|NA H Involved in molybdopterin and thiamine biosynthesis, family 2 MAG.T1.5_02954 1122915.AUGY01000041_gene821 3.5e-33 147.1 Bacteria Bacteria 2EHP8@1,33BF1@2 NA|NA|NA S Multiubiquitin MAG.T1.5_02955 1192759.AKIB01000061_gene1983 6.3e-27 126.3 Sphingomonadales Bacteria 1Q7VB@1224,2DND7@1,2K6JK@204457,2VE0G@28211,32WWM@2 NA|NA|NA S Uncharacterized protein conserved in bacteria (DUF2188) MAG.T1.5_02956 1235457.C404_07720 4.3e-17 94.4 Betaproteobacteria ko:K22299 ko00000,ko03000 Bacteria 1MZMJ@1224,2VVJD@28216,COG1396@1,COG1396@2 NA|NA|NA K Helix-turn-helix XRE-family like proteins MAG.T1.5_02957 883078.HMPREF9695_02493 6.2e-55 221.1 Proteobacteria Bacteria 1R5WS@1224,COG2856@1,COG2856@2 NA|NA|NA E IrrE N-terminal-like domain MAG.T1.5_02958 234267.Acid_4182 8.2e-23 113.2 Bacteria Bacteria COG5606@1,COG5606@2 NA|NA|NA MAG.T1.5_02959 136273.GY22_03875 5.3e-207 727.6 Micrococcaceae copB 3.6.3.4 ko:K01533 R00086 RC00002 ko00000,ko01000 3.A.3.5 Bacteria 1W8GQ@1268,2GIRF@201174,COG2217@1,COG2217@2 NA|NA|NA P ATPase, P-type (transporting), HAD superfamily, subfamily IC MAG.T1.5_02960 335283.Neut_0312 1.4e-77 296.6 Nitrosomonadales copB ko:K07233 ko00000 Bacteria 1MXW6@1224,2VIAG@28216,3741V@32003,COG3667@1,COG3667@2 NA|NA|NA P Copper resistance protein B precursor (CopB) MAG.T1.5_02961 335283.Neut_0311 6.6e-228 797.0 Nitrosomonadales 1.3.3.5,1.7.2.1 ko:K00368,ko:K08100 ko00860,ko00910,ko01110,ko01120,map00860,map00910,map01110,map01120 M00529 R00783,R00785,R02394 RC00086,RC01983 ko00000,ko00001,ko00002,ko01000 Bacteria 1MU0J@1224,2VH96@28216,373XB@32003,COG2132@1,COG2132@2 NA|NA|NA Q Multicopper oxidase type 1 MAG.T1.5_02962 1120977.JHUX01000011_gene3 4.9e-28 130.6 Moraxellaceae Bacteria 1Q128@1224,1TFH9@1236,3NQGE@468,COG4828@1,COG4828@2 NA|NA|NA S Protein of unknown function (DUF1622) MAG.T1.5_02963 314230.DSM3645_26504 1.7e-305 1055.0 Bacteria cga 3.2.1.3 ko:K01178 ko00500,ko01100,map00500,map01100 R01790,R01791,R06199 ko00000,ko00001,ko01000 GH15 Bacteria COG3387@1,COG3387@2 NA|NA|NA G glucan 1,4-alpha-glucosidase activity MAG.T1.5_02964 1267535.KB906767_gene3855 5.9e-160 570.9 Acidobacteriia zwf 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2JKTN@204432,3Y627@57723,COG0364@1,COG0364@2 NA|NA|NA G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone MAG.T1.5_02965 1380394.JADL01000007_gene4558 1.1e-139 503.1 Alphaproteobacteria gnd 1.1.1.343,1.1.1.44 ko:K00033 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200 M00004,M00006 R01528,R10221 RC00001,RC00539 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2620,iNJ661.Rv1122 Bacteria 1QU14@1224,2TT6S@28211,COG1023@1,COG1023@2 NA|NA|NA G 6-phosphogluconate dehydrogenase MAG.T1.5_02966 196490.AUEZ01000002_gene4237 2.3e-16 91.7 Bradyrhizobiaceae ppgK 2.7.1.2,2.7.1.63,5.3.1.9 ko:K00845,ko:K00886,ko:K01810 ko00010,ko00030,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114,M00549 R00299,R01600,R01786,R02187,R02189,R02739,R02740,R03321 RC00002,RC00017,RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1NSQA@1224,2TSPZ@28211,3JRYQ@41294,COG1940@1,COG1940@2 NA|NA|NA GK Transcriptional regulator sugar kinase MAG.T1.5_02967 1123508.JH636456_gene146 0.0 1119.0 Planctomycetes pacS GO:0000041,GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0008150,GO:0015677,GO:0016020,GO:0030001,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0051179,GO:0051234,GO:0071944 3.6.3.4,3.6.3.54 ko:K01533,ko:K17686 ko01524,ko04016,map01524,map04016 R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 Bacteria 2IXAD@203682,COG2217@1,COG2217@2 NA|NA|NA P heavy metal translocating P-type ATPase MAG.T1.5_02970 1132855.KB913035_gene1532 9e-190 669.5 Betaproteobacteria Bacteria 1NX2K@1224,2VI7H@28216,COG5368@1,COG5368@2 NA|NA|NA S Putative glucoamylase MAG.T1.5_02971 330214.NIDE1691 2.5e-72 279.6 Nitrospirae Bacteria 3J0RT@40117,COG0477@1,COG2814@2 NA|NA|NA EGP Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_02972 237368.SCABRO_03846 1e-41 176.8 Bacteria ko:K18480 M00669 ko00000,ko00002,ko02000 3.A.1.27.1 Bacteria COG3009@1,COG3009@2 NA|NA|NA Q Protein conserved in bacteria MAG.T1.5_02973 237368.SCABRO_03847 1.1e-54 220.7 Bacteria iamC ko:K02067,ko:K06192 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria COG1463@1,COG1463@2 NA|NA|NA Q ABC-type transport system involved in resistance to organic solvents, periplasmic component MAG.T1.5_02974 237368.SCABRO_03848 7e-91 340.5 Planctomycetes ttg2A ko:K02065 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 2J2WI@203682,COG1127@1,COG1127@2 NA|NA|NA Q ABC transporter MAG.T1.5_02975 237368.SCABRO_03849 8e-104 384.0 Planctomycetes ko:K02066 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 2IX01@203682,COG0767@1,COG0767@2 NA|NA|NA Q Belongs to the MlaE permease family MAG.T1.5_02976 323097.Nham_4370 0.0 1601.6 Bradyrhizobiaceae pgmB GO:0000287,GO:0003674,GO:0003824,GO:0004805,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008801,GO:0009058,GO:0009292,GO:0009294,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016853,GO:0016866,GO:0016868,GO:0019203,GO:0030312,GO:0033554,GO:0034637,GO:0040007,GO:0042221,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0046351,GO:0046677,GO:0046872,GO:0050896,GO:0051704,GO:0051716,GO:0071704,GO:0071944,GO:1901576 2.4.1.216,2.4.1.64,2.4.1.8,3.1.3.12,3.2.1.28,5.4.2.6 ko:K00691,ko:K01087,ko:K01194,ko:K01838,ko:K03731,ko:K05342 ko00500,ko01100,map00500,map01100 R00010,R01555,R02727,R02728,R02778,R11310 RC00017,RC00049,RC00408 ko00000,ko00001,ko00537,ko01000 GH37,GH65 Bacteria 1MWJE@1224,2U1CG@28211,3JWWP@41294,COG0637@1,COG0637@2,COG1554@1,COG1554@2 NA|NA|NA G Glycosyl hydrolase family 65, C-terminal domain MAG.T1.5_02977 420324.KI912022_gene340 0.0 1218.0 Methylobacteriaceae 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 R02111 ko00000,ko00001,ko01000 GT35 Bacteria 1JT1D@119045,1MW4J@1224,2TRER@28211,COG0058@1,COG0058@2 NA|NA|NA G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties MAG.T1.5_02978 338966.Ppro_0419 2.5e-281 974.5 Desulfuromonadales glgX 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 ko00000,ko00001,ko00002,ko01000 CBM48,GH13 Bacteria 1MU19@1224,2WKFS@28221,42P3J@68525,43U1C@69541,COG1523@1,COG1523@2 NA|NA|NA G Belongs to the glycosyl hydrolase 13 family MAG.T1.5_02979 1038860.AXAP01000015_gene2094 0.0 1416.7 Bradyrhizobiaceae xfp 4.1.2.22,4.1.2.9 ko:K01621 ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120 R00761,R01621 RC00032,RC00226 ko00000,ko00001,ko01000 Bacteria 1MVSE@1224,2TU2E@28211,3JRH2@41294,COG3957@1,COG3957@2 NA|NA|NA G aldehyde-lyase activity MAG.T1.5_02980 859657.RPSI07_mp0767 9e-111 406.8 Betaproteobacteria Bacteria 1R5ET@1224,2VP93@28216,COG1028@1,COG1028@2 NA|NA|NA IQ short chain dehydrogenase MAG.T1.5_02981 1123399.AQVE01000048_gene395 7.2e-30 136.7 Proteobacteria Bacteria 1R3CF@1224,2C6PE@1,333XY@2 NA|NA|NA MAG.T1.5_02982 330214.NIDE0039 4.1e-20 104.0 Bacteria Bacteria COG2329@1,COG2329@2 NA|NA|NA S heme oxygenase (decyclizing) activity MAG.T1.5_02984 330214.NIDE3893 1.4e-24 119.0 Bacteria ko:K12263 ko00000 Bacteria COG2010@1,COG2010@2 NA|NA|NA C Cytochrome c MAG.T1.5_02985 330214.NIDE3910 5.6e-100 370.9 Nitrospirae GO:0003674,GO:0003824,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0009987,GO:0010333,GO:0016829,GO:0016835,GO:0016838,GO:0042214,GO:0044237,GO:0044238,GO:0044255,GO:0071704 4.2.3.118 ko:K16218 ko00000,ko01000 Bacteria 3J1CW@40117,COG3170@1,COG3170@2 NA|NA|NA NU Protein of unknown function (DUF1207) MAG.T1.5_02986 1123269.NX02_09210 3e-132 478.4 Sphingomonadales yhhJ ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1MUIA@1224,2K1I9@204457,2TU4P@28211,COG0842@1,COG0842@2 NA|NA|NA V ABC-2 family transporter protein MAG.T1.5_02987 177437.HRM2_48510 0.0 1235.7 Desulfobacterales ko:K01990,ko:K13926 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1QTT9@1224,2MJER@213118,2X713@28221,43BJ5@68525,COG0842@1,COG0842@2,COG1129@1,COG1129@2 NA|NA|NA V ABC-2 family transporter protein MAG.T1.5_02988 177437.HRM2_48520 8.7e-83 313.9 Desulfobacterales yhiI GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K01993 ko00000 Bacteria 1MUG6@1224,2MPK8@213118,2WMKG@28221,42NC1@68525,COG0845@1,COG0845@2 NA|NA|NA M Biotin-lipoyl like MAG.T1.5_02989 338963.Pcar_3003 6.7e-161 574.7 Deltaproteobacteria Bacteria 1MYXE@1224,2WR7T@28221,42TA7@68525,COG1538@1,COG1538@2 NA|NA|NA M Outer membrane efflux protein MAG.T1.5_02991 234267.Acid_3304 3.7e-161 574.3 Acidobacteria 1.1.1.14,1.2.1.46 ko:K00008,ko:K00148 ko00040,ko00051,ko00625,ko00680,ko01100,ko01120,ko01200,map00040,map00051,map00625,map00680,map01100,map01120,map01200 M00014 R00604,R00875,R01896 RC00085,RC00102,RC00188 ko00000,ko00001,ko00002,ko01000 Bacteria 3Y6JK@57723,COG1063@1,COG1063@2 NA|NA|NA E Alcohol dehydrogenase GroES-like domain MAG.T1.5_02992 1242864.D187_001897 2.2e-56 224.9 delta/epsilon subdivisions 3.5.3.18 ko:K01482 ko00000,ko01000,ko04147 Bacteria 1RD1N@1224,431W1@68525,COG0251@1,COG0251@2 NA|NA|NA J Endoribonuclease L-PSP MAG.T1.5_02993 665942.HMPREF1022_01798 4.8e-76 290.8 Desulfovibrionales Bacteria 1MVEH@1224,2MA3T@213115,2WKUR@28221,42MDR@68525,COG0667@1,COG0667@2 NA|NA|NA C PFAM aldo keto reductase MAG.T1.5_02994 404380.Gbem_0402 5.3e-48 197.2 Deltaproteobacteria Bacteria 1MVEH@1224,2WKUR@28221,42MDR@68525,COG0667@1,COG0667@2 NA|NA|NA C aldo keto reductase MAG.T1.5_02995 526225.Gobs_1833 4.8e-127 461.1 Frankiales adh 1.1.1.14,1.2.1.46 ko:K00008,ko:K00148 ko00040,ko00051,ko00625,ko00680,ko01100,ko01120,ko01200,map00040,map00051,map00625,map00680,map01100,map01120,map01200 M00014 R00604,R00875,R01896 RC00085,RC00102,RC00188 ko00000,ko00001,ko00002,ko01000 Bacteria 2IA6Q@201174,4ES1U@85013,COG1063@1,COG1063@2 NA|NA|NA C PFAM Alcohol dehydrogenase zinc-binding domain protein MAG.T1.5_02996 1156919.QWC_20802 6.2e-143 513.8 Betaproteobacteria 1.2.1.12,1.2.1.59,1.4.1.16 ko:K00134,ko:K00150,ko:K03340 ko00010,ko00300,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00300,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00526,M00552 R01061,R01063,R02755 RC00006,RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 Bacteria 1N2N1@1224,2VNRF@28216,COG0057@1,COG0057@2 NA|NA|NA C TIGRFAM Glyceraldehyde-3-phosphate dehydrogenase, type II MAG.T1.5_02997 1459636.NTE_01678 7.1e-111 407.5 Thaumarchaeota pgk GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 Archaea 41SMB@651137,COG0126@1,arCOG00496@2157 NA|NA|NA G Phosphoglycerate kinase MAG.T1.5_02998 478741.JAFS01000002_gene551 0.0 1190.3 unclassified Verrucomicrobia ppsA 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 Bacteria 37FY0@326457,46SVA@74201,COG0574@1,COG0574@2,COG1080@1,COG1080@2 NA|NA|NA H Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate MAG.T1.5_02999 118168.MC7420_3431 5.1e-20 104.4 Oscillatoriales Bacteria 1G896@1117,1HC6D@1150,COG0607@1,COG0607@2 NA|NA|NA P Rhodanese Homology Domain MAG.T1.5_03000 1454004.AW11_01657 2.8e-203 714.9 Betaproteobacteria preT 1.2.7.1 ko:K00171,ko:K03737 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034,R10866 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1MU2H@1224,2VM9R@28216,COG0493@1,COG0493@2,COG1144@1,COG1144@2 NA|NA|NA C Pyridine nucleotide-disulphide oxidoreductase MAG.T1.5_03001 345341.KUTG_00476 5.8e-135 487.3 Bacteria porB 1.2.7.1 ko:K00170 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria COG1013@1,COG1013@2 NA|NA|NA C oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor MAG.T1.5_03002 395495.Lcho_2150 9.2e-146 523.5 unclassified Burkholderiales porA 1.2.7.1 ko:K00169 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1KK3S@119065,1MVM0@1224,2VJSA@28216,COG0674@1,COG0674@2 NA|NA|NA C Pyruvate:ferredoxin oxidoreductase core domain II MAG.T1.5_03003 888050.HMPREF9004_0872 2.1e-55 222.2 Actinobacteria porC 1.2.1.58,1.2.7.1 ko:K00172,ko:K18357 ko00010,ko00020,ko00360,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00360,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R02450,R08034 RC00004,RC00250,RC02742,RC02833,RC02860 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2IJIZ@201174,4D5MR@85005,COG1014@1,COG1014@2 NA|NA|NA C 2-oxoacid acceptor oxidoreductase, gamma subunit, pyruvate 2-ketoisovalerate family MAG.T1.5_03007 330214.NIDE3911 6.7e-21 107.1 Bacteria Bacteria COG1664@1,COG1664@2 NA|NA|NA M Polymer-forming cytoskeletal MAG.T1.5_03008 330214.NIDE3912 4.8e-70 270.4 Bacteria Bacteria COG4244@1,COG4244@2 NA|NA|NA E Membrane MAG.T1.5_03010 330214.NIDE3913 1.1e-290 1005.4 Bacteria Bacteria COG1807@1,COG1807@2 NA|NA|NA M 4-amino-4-deoxy-L-arabinose transferase activity MAG.T1.5_03011 485913.Krac_6477 1.1e-142 513.5 Bacteria Bacteria COG0582@1,COG0582@2 NA|NA|NA L DNA integration MAG.T1.5_03012 330214.NIDE2246 5.4e-77 293.9 Bacteria Bacteria COG1801@1,COG1801@2 NA|NA|NA L Protein of unknown function DUF72 MAG.T1.5_03013 1123487.KB892863_gene1961 1.2e-23 116.3 Rhodocyclales Bacteria 1NDT4@1224,2DPY2@1,2KXQT@206389,2WC4I@28216,333WA@2 NA|NA|NA S AP2 domain MAG.T1.5_03018 211165.AJLN01000015_gene2249 1.3e-07 64.3 Stigonemataceae Bacteria 1GC6M@1117,1JK8B@1189,2EANP@1,313CM@2 NA|NA|NA MAG.T1.5_03019 163908.KB235896_gene4911 3.4e-30 138.7 Nostocales Bacteria 1GJWD@1117,1HQJY@1161,2E1Q3@1,30N4F@2 NA|NA|NA S Prokaryotic E2 family D MAG.T1.5_03020 927677.ALVU02000002_gene309 6.8e-33 147.5 Cyanobacteria Bacteria 1GCCI@1117,2EPRU@1,33HCC@2 NA|NA|NA MAG.T1.5_03021 1183438.GKIL_1750 2.2e-48 199.5 Cyanobacteria Bacteria 1G5NY@1117,COG0476@1,COG0476@2 NA|NA|NA H ThiF family MAG.T1.5_03024 330214.NIDE2582 0.0 1205.7 Nitrospirae dnaE GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 3J0FE@40117,COG0587@1,COG0587@2 NA|NA|NA L DNA-directed DNA polymerase MAG.T1.5_03029 1144343.PMI41_01237 2e-27 128.3 Alphaproteobacteria ko:K07334 ko00000,ko02048 Bacteria 1MZ4I@1224,2UD9W@28211,COG3549@1,COG3549@2 NA|NA|NA S Plasmid maintenance system killer MAG.T1.5_03030 314278.NB231_12801 3.9e-26 124.0 Gammaproteobacteria ko:K21498 ko00000,ko02048 Bacteria 1N2TD@1224,1SE1M@1236,COG3093@1,COG3093@2 NA|NA|NA K TIGRFAM Addiction module antidote protein, HigA MAG.T1.5_03031 75379.Tint_0304 6.4e-117 427.6 unclassified Burkholderiales ko:K07496 ko00000 Bacteria 1KN7Z@119065,1MUU0@1224,2VJG9@28216,COG0675@1,COG0675@2 NA|NA|NA L Helix-turn-helix domain MAG.T1.5_03035 75379.Tint_0304 2.4e-124 452.2 unclassified Burkholderiales ko:K07496 ko00000 Bacteria 1KN7Z@119065,1MUU0@1224,2VJG9@28216,COG0675@1,COG0675@2 NA|NA|NA L Helix-turn-helix domain MAG.T1.5_03044 32057.KB217478_gene2345 1.8e-15 89.0 Nostocales Bacteria 1G7VQ@1117,1HPXY@1161,COG4453@1,COG4453@2 NA|NA|NA S Protein of unknown function (DUF1778) MAG.T1.5_03045 670307.HYPDE_23088 7.9e-46 190.3 Bacteria 2.3.1.189 ko:K15520 ko00000,ko01000 Bacteria COG0454@1,COG0456@2 NA|NA|NA K acetyltransferase MAG.T1.5_03046 264732.Moth_0675 4.7e-61 243.0 Clostridia helD 3.6.4.12,5.99.1.2 ko:K03168,ko:K03658,ko:K06131 ko00564,ko01100,map00564,map01100 R07390 RC00017 ko00000,ko00001,ko01000,ko03032,ko03400 Bacteria 1UNF1@1239,24HXY@186801,COG0507@1,COG0507@2,COG0551@1,COG0551@2,COG1112@1,COG1112@2,COG1502@1,COG1502@2 NA|NA|NA L AAA domain MAG.T1.5_03048 264462.Bd1582 1.4e-09 69.3 Bdellovibrionales ssb GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006298,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008047,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030234,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0042802,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:0098772,GO:1901360,GO:1901363,GO:1901576 ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 ko00000,ko00001,ko03029,ko03032,ko03400 Bacteria 1RCWT@1224,2MT2P@213481,2WNAN@28221,42TV9@68525,COG0629@1,COG0629@2 NA|NA|NA L Single-strand binding protein family MAG.T1.5_03051 521045.Kole_1767 5.7e-19 101.7 Bacteria ko:K06993 ko00000 Bacteria COG3341@1,COG3341@2 NA|NA|NA L Caulimovirus viroplasmin MAG.T1.5_03053 877418.ATWV01000006_gene2069 2.2e-15 88.6 Spirochaetes smf ko:K04096 ko00000 Bacteria 2JAX3@203691,COG0758@1,COG0758@2 NA|NA|NA LU Protein of unknown function (DUF2493) MAG.T1.5_03055 1121396.KB892905_gene4209 1.9e-08 65.5 Desulfobacterales Bacteria 1P545@1224,2BX7T@1,2MP44@213118,2WXAH@28221,2ZFES@2,433ME@68525 NA|NA|NA MAG.T1.5_03056 1449126.JQKL01000069_gene3628 8.7e-10 70.5 Clostridia ydjM GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0031668,GO:0033554,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:0071944 ko:K07038 ko00000 Bacteria 1V3QT@1239,24WWI@186801,COG1988@1,COG1988@2 NA|NA|NA S LexA-binding, inner membrane-associated putative hydrolase MAG.T1.5_03058 1415780.JPOG01000001_gene2866 8.7e-20 104.8 Xanthomonadales ko:K18481,ko:K18640 M00670 ko00000,ko00002,ko02000,ko04812 3.A.1.27.4,3.A.1.27.5 Bacteria 1P7BK@1224,1RRN2@1236,1X4Q7@135614,COG0443@1,COG0443@2 NA|NA|NA O PRTRC system protein D MAG.T1.5_03060 156889.Mmc1_2895 1.6e-29 135.2 Alphaproteobacteria higB ko:K07334 ko00000,ko02048 Bacteria 1MZKX@1224,2UBQF@28211,COG3549@1,COG3549@2 NA|NA|NA S Plasmid maintenance system killer MAG.T1.5_03061 227377.CBU_1490 2.6e-20 104.8 Gammaproteobacteria higA ko:K21498 ko00000,ko02048 Bacteria 1N76J@1224,1SCYV@1236,COG3093@1,COG3093@2 NA|NA|NA K TIGRFAM Addiction module antidote protein, HigA MAG.T1.5_03062 1268068.PG5_58590 7.8e-43 181.4 Bacteria Bacteria 2F1KV@1,33UM8@2 NA|NA|NA MAG.T1.5_03064 330214.NIDE2457 5e-238 830.1 Nitrospirae clpC ko:K03696 ko01100,map01100 ko00000,ko03110 Bacteria 3J0B4@40117,COG0542@1,COG0542@2 NA|NA|NA O C-terminal, D2-small domain, of ClpB protein MAG.T1.5_03065 330214.NIDE2458 1.7e-156 558.9 Nitrospirae tsaD GO:0000287,GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140030,GO:0140032,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 ko:K01409,ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 R10648 RC00070,RC00416 ko00000,ko00001,ko00002,ko01000,ko02044,ko03016 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 Bacteria 3J0I3@40117,COG0533@1,COG0533@2 NA|NA|NA J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction MAG.T1.5_03066 330214.NIDE2459 4.6e-251 873.6 Nitrospirae hflX ko:K03665 ko00000,ko03009 Bacteria 3J0AE@40117,COG2262@1,COG2262@2 NA|NA|NA S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis MAG.T1.5_03067 330214.NIDE2460 2.7e-92 344.7 Nitrospirae nth 4.2.99.18 ko:K10773 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 3J0K6@40117,COG0177@1,COG0177@2 NA|NA|NA L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate MAG.T1.5_03068 330214.NIDE2461 1.2e-131 476.1 Nitrospirae yicC GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009022,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:0140101,GO:1901360,GO:1901361,GO:1901575 Bacteria 3J0QJ@40117,COG1561@1,COG1561@2 NA|NA|NA S Domain of unknown function (DUF1732) MAG.T1.5_03069 330214.NIDE2462 7.7e-113 413.3 Nitrospirae gmk GO:0003674,GO:0003824,GO:0004385,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8,4.1.1.23 ko:K00942,ko:K01591 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00050,M00051 R00332,R00965,R02090 RC00002,RC00409 ko00000,ko00001,ko00002,ko01000 iAPECO1_1312.APECO1_2813,iIT341.HP0321,iPC815.YPO0040,iSBO_1134.SBO_3729,iSFV_1184.SFV_3881,iSFxv_1172.SFxv_4016,iUTI89_1310.UTI89_C4193 Bacteria 3J0JT@40117,COG0194@1,COG0194@2 NA|NA|NA F Essential for recycling GMP and indirectly, cGMP MAG.T1.5_03070 330214.NIDE2463 1e-49 202.6 Nitrospirae rpoZ GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944 2.7.7.6 ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 Bacteria 3J0UJ@40117,COG1758@1,COG1758@2 NA|NA|NA K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits MAG.T1.5_03071 330214.NIDE2464 1.9e-191 675.2 Nitrospirae coaBC 4.1.1.36,6.3.2.5 ko:K01598,ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0GK@40117,COG0452@1,COG0452@2 NA|NA|NA H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine MAG.T1.5_03072 330214.NIDE2465 7.3e-52 210.7 Bacteria 2.7.11.1 ko:K14949,ko:K20543 ko05152,map05152 ko00000,ko00001,ko01000,ko01001,ko02000 1.B.55.3 Bacteria COG3118@1,COG3118@2 NA|NA|NA O belongs to the thioredoxin family MAG.T1.5_03073 330214.NIDE2466 7.5e-75 286.6 Nitrospirae aroQ 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 iIT341.HP1038 Bacteria 3J199@40117,COG0757@1,COG0757@2 NA|NA|NA E Catalyzes a trans-dehydration via an enolate intermediate MAG.T1.5_03074 330214.NIDE2467 1.9e-98 365.2 Nitrospirae efp GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006448,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0072344,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112,GO:2000113,GO:2001124,GO:2001125 ko:K02356 ko00000,ko03012 Bacteria 3J0JC@40117,COG0231@1,COG0231@2 NA|NA|NA J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase MAG.T1.5_03075 330214.NIDE2468 8.6e-68 263.1 Nitrospirae accB 2.3.1.12,4.1.1.3,6.4.1.1 ko:K00627,ko:K01571,ko:K01960,ko:K02160 ko00010,ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko01230,map00010,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212,map01230 M00082,M00173,M00307,M00376,M00620 R00209,R00217,R00344,R00742,R02569 RC00004,RC00040,RC00367,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000,ko02000 3.B.1.1.1 Bacteria 3J0PI@40117,COG0511@1,COG0511@2 NA|NA|NA I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA MAG.T1.5_03076 330214.NIDE2469 3.9e-251 873.6 Nitrospirae accC 6.3.4.14,6.4.1.1,6.4.1.2 ko:K01959,ko:K01961 ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko01230,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212,map01230 M00082,M00173,M00376,M00620 R00344,R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0AJ@40117,COG0439@1,COG0439@2 NA|NA|NA I Biotin carboxylase C-terminal domain MAG.T1.5_03077 330214.NIDE2470 4.6e-77 294.3 Nitrospirae thiE GO:0000287,GO:0003674,GO:0003824,GO:0004789,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3,2.7.1.49,2.7.4.7 ko:K00788,ko:K14153 ko00730,ko01100,map00730,map01100 M00127 R03223,R03471,R04509,R10712 RC00002,RC00017,RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 iE2348C_1286.E2348C_4300,iSSON_1240.SSON_4166 Bacteria 3J0ND@40117,COG0352@1,COG0352@2 NA|NA|NA H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) MAG.T1.5_03078 330214.NIDE2471 3.2e-74 285.0 Nitrospirae bioD GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.3 ko:K01935 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03182 RC00868 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0SI@40117,COG0132@1,COG0132@2 NA|NA|NA H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring MAG.T1.5_03079 1356854.N007_03220 2.9e-32 145.6 Alicyclobacillaceae Bacteria 1TP76@1239,279C6@186823,4HAA6@91061,COG1028@1,COG1028@2 NA|NA|NA IQ Enoyl-(Acyl carrier protein) reductase MAG.T1.5_03080 330214.NIDE2474 1.7e-141 508.8 Bacteria Bacteria 2DGGU@1,2ZVXA@2 NA|NA|NA MAG.T1.5_03081 330214.NIDE2475 0.0 1597.8 Bacteria rocA 1.2.1.88,1.5.5.2 ko:K00294,ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 iAF987.Gmet_3512,iYO844.BSU37780 Bacteria COG0506@1,COG0506@2,COG1012@1,COG1012@2 NA|NA|NA E proline dehydrogenase activity MAG.T1.5_03082 330214.NIDE1715 1.6e-153 550.4 Bacteria Bacteria COG3209@1,COG3209@2 NA|NA|NA M self proteolysis MAG.T1.5_03083 330214.NIDE1715 0.0 1244.6 Bacteria Bacteria COG3209@1,COG3209@2 NA|NA|NA M self proteolysis MAG.T1.5_03084 330214.NIDE1715 1.3e-189 669.5 Bacteria Bacteria COG3209@1,COG3209@2 NA|NA|NA M self proteolysis MAG.T1.5_03086 236097.ADG881_2260 2.5e-29 134.4 Oceanospirillales ko:K07483,ko:K07497 ko00000 Bacteria 1MZ3D@1224,1S9EI@1236,1XQ9X@135619,COG2963@1,COG2963@2 NA|NA|NA L L COG2801 Transposase and inactivated derivatives MAG.T1.5_03087 1266925.JHVX01000002_gene795 3.4e-81 308.1 Nitrosomonadales ko:K07497 ko00000 Bacteria 1MVXQ@1224,2VHER@28216,372VZ@32003,COG2801@1,COG2801@2 NA|NA|NA L PFAM Integrase, catalytic MAG.T1.5_03088 330214.NIDE2479 1.4e-47 195.3 Bacteria ko:K06950 ko00000 Bacteria COG1418@1,COG1418@2 NA|NA|NA S mRNA catabolic process MAG.T1.5_03089 330214.NIDE2480 1.8e-158 565.1 Bacteria desC 1.14.19.1 ko:K00507 ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212 R02222 RC00917 ko00000,ko00001,ko01000,ko01004 Bacteria COG1398@1,COG1398@2 NA|NA|NA I oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water MAG.T1.5_03090 330214.NIDE2481 5.9e-155 553.5 Nitrospirae mrp ko:K03593 ko00000,ko03029,ko03036 Bacteria 3J0Z6@40117,COG0489@1,COG0489@2 NA|NA|NA D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP MAG.T1.5_03091 330214.NIDE2482 6.7e-50 203.0 Nitrospirae 1.7.1.15 ko:K00363,ko:K05710 ko00360,ko00910,ko01120,ko01220,map00360,map00910,map01120,map01220 M00530,M00545 R00787,R06782,R06783 RC00098,RC00176 br01602,ko00000,ko00001,ko00002,ko01000 Bacteria 3J1E7@40117,COG2146@1,COG2146@2 NA|NA|NA P Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_03095 330214.NIDE2486 1.2e-40 172.6 Bacteria Bacteria 2EGJW@1,33AC1@2 NA|NA|NA MAG.T1.5_03096 330214.NIDE2487 0.0 1129.8 Bacteria 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 Bacteria COG1070@1,COG1070@2 NA|NA|NA G xylulokinase activity MAG.T1.5_03097 330214.NIDE2488 2.3e-188 664.8 Bacteria Bacteria 28II6@1,2Z8JB@2 NA|NA|NA MAG.T1.5_03098 330214.NIDE2489 1.6e-206 725.3 Bacteria Bacteria 28MEN@1,2ZASA@2 NA|NA|NA MAG.T1.5_03099 330214.NIDE2490 3.9e-108 397.5 Bacteria Bacteria 29ZH8@1,30MGZ@2 NA|NA|NA MAG.T1.5_03100 330214.NIDE2491 6.8e-153 546.6 Bacteria Bacteria 28MYQ@1,2ZB5K@2 NA|NA|NA MAG.T1.5_03101 330214.NIDE2492 1.5e-130 472.2 Bacteria Bacteria 2ANS9@1,31DS7@2 NA|NA|NA MAG.T1.5_03102 330214.NIDE2493 1.4e-221 775.4 Nitrospirae GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0032886,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0065007 ko:K06990 ko00000,ko04812 Bacteria 3J0U4@40117,COG1355@1,COG1355@2 NA|NA|NA S Memo-like protein MAG.T1.5_03103 370438.PTH_0499 1.8e-25 122.1 Peptococcaceae Bacteria 1VKNI@1239,24VDB@186801,266AG@186807,COG1848@1,COG1848@2 NA|NA|NA S PIN domain MAG.T1.5_03104 370438.PTH_0500 1.2e-10 72.0 Clostridia Bacteria 1W48M@1239,255K1@186801,COG2002@1,COG2002@2 NA|NA|NA K SpoVT / AbrB like domain MAG.T1.5_03105 330214.NIDE2494 4.1e-51 207.2 Bacteria ko:K06186 ko00000,ko02000 1.B.33.1 Bacteria COG2913@1,COG2913@2 NA|NA|NA J Gram-negative-bacterium-type cell outer membrane assembly MAG.T1.5_03106 330214.NIDE2497 5.2e-93 347.1 Nitrospirae ppiB 5.2.1.8 ko:K01802,ko:K03768 ko00000,ko01000,ko03110 Bacteria 3J18H@40117,COG0652@1,COG0652@2 NA|NA|NA O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides MAG.T1.5_03107 330214.NIDE2498 4.4e-251 873.6 Bacteria ko:K02238 M00429 ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 Bacteria COG2333@1,COG2333@2 NA|NA|NA N competence protein COMEC MAG.T1.5_03108 330214.NIDE2502 0.0 1270.8 Nitrospirae 2.1.1.72 ko:K03427 ko00000,ko01000,ko02048 Bacteria 3J0XA@40117,COG0286@1,COG0286@2 NA|NA|NA L Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_03109 397945.Aave_3358 6.9e-58 231.5 Comamonadaceae hsdS 3.1.21.3 ko:K01154 ko00000,ko01000,ko02048 Bacteria 1Q4FB@1224,2VR1G@28216,4AF39@80864,COG0732@1,COG0732@2 NA|NA|NA L Type I restriction modification DNA specificity domain MAG.T1.5_03110 330214.NIDE2504 6.5e-57 226.5 Bacteria GO:0001666,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0036293,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0045926,GO:0045927,GO:0046483,GO:0048518,GO:0048519,GO:0050789,GO:0050896,GO:0065007,GO:0070482,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360 Bacteria COG4679@1,COG4679@2 NA|NA|NA K PFAM Phage derived protein Gp49-like (DUF891) MAG.T1.5_03111 330214.NIDE2505 1.7e-61 241.9 Nitrospirae Bacteria 3J1D7@40117,COG1396@1,COG1396@2 NA|NA|NA K Helix-turn-helix domain MAG.T1.5_03112 330214.NIDE2506 0.0 1812.3 Nitrospirae 3.1.21.3 ko:K01153 ko00000,ko01000,ko02048 Bacteria 3J0QC@40117,COG0610@1,COG0610@2 NA|NA|NA L Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_03113 330214.NIDE2507 5.3e-108 397.1 Nitrospirae radC ko:K03630 ko00000 Bacteria 3J12V@40117,COG2003@1,COG2003@2 NA|NA|NA L Belongs to the UPF0758 family MAG.T1.5_03114 627192.SLG_07160 3.2e-164 584.7 Sphingomonadales namA 1.6.99.1 ko:K00354 R00282 RC00001 ko00000,ko01000 Bacteria 1MVE0@1224,2K127@204457,2TQPY@28211,COG1902@1,COG1902@2 NA|NA|NA C NADH flavin oxidoreductase NADH oxidase MAG.T1.5_03115 330214.NIDE2509 6e-49 199.9 Bacteria mazF ko:K07171 ko00000,ko01000,ko02048 Bacteria COG2337@1,COG2337@2 NA|NA|NA T Toxic component of a toxin-antitoxin (TA) module MAG.T1.5_03116 330214.NIDE2510 3.1e-40 170.6 Bacteria mazE ko:K07172,ko:K18842 ko00000,ko02048 Bacteria COG2336@1,COG2336@2 NA|NA|NA T PFAM SpoVT AbrB MAG.T1.5_03117 330214.NIDE2514 2.4e-194 684.9 Bacteria ko:K03535 ko00000,ko02000 2.A.1.14.1 Bacteria COG2271@1,COG2271@2 NA|NA|NA G transmembrane transporter activity MAG.T1.5_03118 330214.NIDE2515 0.0 2005.7 Bacteria ko:K07290 ko00000 9.B.121 Bacteria COG2982@1,COG2982@2 NA|NA|NA M Protein involved in outer membrane biogenesis MAG.T1.5_03119 330214.NIDE2516 7.6e-195 686.4 Nitrospirae pepP 3.4.11.9,3.4.13.9 ko:K01262,ko:K01271 ko00000,ko01000,ko01002 Bacteria 3J0R0@40117,COG0006@1,COG0006@2 NA|NA|NA E Metallopeptidase family M24 MAG.T1.5_03120 330214.NIDE2517 5.1e-168 597.0 Nitrospirae sdhB 1.3.5.1,1.3.5.4 ko:K00240 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 Bacteria 3J14K@40117,COG0479@1,COG0479@2 NA|NA|NA C Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family MAG.T1.5_03121 330214.NIDE2518 4.3e-58 230.7 Bacteria Bacteria COG1371@1,COG1371@2 NA|NA|NA J PFAM Archease protein family (DUF101 UPF0211) MAG.T1.5_03122 330214.NIDE2519 5.7e-264 916.4 Nitrospirae rtcB 6.5.1.3 ko:K14415 ko00000,ko01000,ko03016 Bacteria 3J0X0@40117,COG1690@1,COG1690@2 NA|NA|NA S tRNA-splicing ligase RtcB MAG.T1.5_03124 330214.NIDE2521 6.5e-75 287.3 Bacteria Bacteria COG5002@1,COG5002@2 NA|NA|NA T protein histidine kinase activity MAG.T1.5_03125 330214.NIDE2522 0.0 1300.4 Nitrospirae actA ko:K13591 ko04112,map04112 M00511 ko00000,ko00001,ko00002,ko02022 Bacteria 3J10M@40117,COG2199@1,COG3706@2,COG5001@1,COG5001@2 NA|NA|NA T Putative diguanylate phosphodiesterase MAG.T1.5_03126 1122611.KB903939_gene305 9.8e-66 258.1 Actinobacteria Bacteria 2IFW2@201174,COG0457@1,COG0457@2 NA|NA|NA S Tetratricopeptide repeat MAG.T1.5_03127 330214.NIDE2524 5.1e-233 813.5 Nitrospirae 1.6.1.1 ko:K00322 ko00760,ko01100,map00760,map01100 R00112 RC00001 ko00000,ko00001,ko01000 Bacteria 3J0IM@40117,COG1249@1,COG1249@2 NA|NA|NA C Evidence 2a Function of homologous gene experimentally demonstrated in an other organism MAG.T1.5_03128 330214.NIDE2525 7.6e-139 500.0 Bacteria Bacteria COG1639@1,COG1639@2 NA|NA|NA T HDOD domain MAG.T1.5_03130 330214.NIDE2527 5.1e-154 550.4 Nitrospirae hdrB ko:K00241 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 Bacteria 3J175@40117,COG2048@1,COG2048@2 NA|NA|NA C Cysteine-rich domain MAG.T1.5_03131 330214.NIDE2528 8.5e-48 196.1 Bacteria Bacteria COG0662@1,COG0662@2 NA|NA|NA G Cupin 2, conserved barrel domain protein MAG.T1.5_03132 330214.NIDE2529 3.5e-108 397.9 Bacteria gspA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 ko:K02450 M00331 ko00000,ko00002,ko02044 9.B.42 Bacteria COG3267@1,COG3267@2 NA|NA|NA MAG.T1.5_03133 330214.NIDE2530 1.4e-160 572.4 Bacteria Bacteria COG0834@1,COG0834@2 NA|NA|NA ET amino acid transport MAG.T1.5_03135 330214.NIDE2534 5.5e-159 567.0 Bacteria aniA 1.16.3.3,1.7.2.1 ko:K00368,ko:K22349 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 Bacteria COG2132@1,COG2132@2 NA|NA|NA Q Multicopper oxidase MAG.T1.5_03136 330214.NIDE2535 2.4e-99 368.2 Nitrospirae ko:K10914,ko:K21564 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 ko00000,ko00001,ko03000 Bacteria 3J18E@40117,COG0664@1,COG0664@2 NA|NA|NA K helix_turn_helix, cAMP Regulatory protein MAG.T1.5_03137 330214.NIDE2536 0.0 1130.9 Nitrospirae tkt 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0MM@40117,COG0021@1,COG0021@2 NA|NA|NA G Transketolase, pyrimidine binding domain MAG.T1.5_03138 330214.NIDE2538 2.5e-93 348.2 Nitrospirae pyrR GO:0003674,GO:0003700,GO:0006139,GO:0006220,GO:0006221,GO:0006355,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019637,GO:0019693,GO:0031323,GO:0031326,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0055086,GO:0060255,GO:0065007,GO:0071704,GO:0072527,GO:0072528,GO:0080090,GO:0090407,GO:0140110,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141 2.4.2.9 ko:K02825 ko00240,ko01100,map00240,map01100 R00966 RC00063 ko00000,ko00001,ko01000,ko03000 Bacteria 3J0JX@40117,COG2065@1,COG2065@2 NA|NA|NA F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant MAG.T1.5_03139 330214.NIDE2539 8.5e-157 559.7 Nitrospirae pyrB GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 ko:K00608,ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 iYO844.BSU15490 Bacteria 3J0FJ@40117,COG0540@1,COG0540@2 NA|NA|NA F Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain MAG.T1.5_03140 330214.NIDE2540 3e-224 784.3 Nitrospirae pyrC GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0D7@40117,COG0044@1,COG0044@2 NA|NA|NA F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily MAG.T1.5_03142 330214.NIDE2542 7.2e-201 706.4 Nitrospirae carA GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1383 Bacteria 3J0CS@40117,COG0505@1,COG0505@2 NA|NA|NA F Carbamoyl-phosphate synthase small chain, CPSase domain MAG.T1.5_03143 330214.NIDE2543 1.8e-165 588.6 Nitrospirae sppA ko:K04773 ko00000,ko01000,ko01002 Bacteria 3J13W@40117,COG0616@1,COG0616@2 NA|NA|NA OU Peptidase family S49 MAG.T1.5_03144 330214.NIDE2544 1.1e-167 595.9 Bacteria Bacteria COG4783@1,COG4783@2 NA|NA|NA L chaperone-mediated protein folding MAG.T1.5_03145 330214.NIDE2545 0.0 2006.1 Nitrospirae carB GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 iAF1260.b0033,iBWG_1329.BWG_0031,iECDH10B_1368.ECDH10B_0034,iECDH1ME8569_1439.ECDH1ME8569_0031,iECUMN_1333.ECUMN_0034,iEcDH1_1363.EcDH1_3566,iJN746.PP_4723,iJO1366.b0033,iJR904.b0033,iPC815.YPO0482,iY75_1357.Y75_RS00170,iYL1228.KPN_00041 Bacteria 3J0BC@40117,COG0458@1,COG0458@2 NA|NA|NA F Carbamoyl-phosphate synthetase large chain, oligomerisation domain MAG.T1.5_03146 330214.NIDE2546 1.5e-77 295.4 Nitrospirae greA GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006354,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0030312,GO:0031323,GO:0031326,GO:0032774,GO:0032784,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 ko:K03624 ko00000,ko03021 Bacteria 3J0NA@40117,COG0782@1,COG0782@2 NA|NA|NA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides MAG.T1.5_03147 330214.NIDE2547 5.3e-126 457.2 Nitrospirae ko:K22205 ko00000,ko01000 Bacteria 3J0RG@40117,COG1912@1,COG1912@2 NA|NA|NA S S-adenosyl-l-methionine hydroxide adenosyltransferase MAG.T1.5_03148 330214.NIDE2548 7.1e-161 573.5 Bacteria ko:K15727 ko00000,ko02000 8.A.1.2.1 Bacteria COG0845@1,COG0845@2 NA|NA|NA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family MAG.T1.5_03150 330214.NIDE2550 2.1e-209 734.9 Nitrospirae bioA 2.6.1.105,2.6.1.62 ko:K00833,ko:K19563 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03231,R10699 RC00006,RC00062,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 iSB619.SA_RS12705 Bacteria 3J0D9@40117,COG0161@1,COG0161@2 NA|NA|NA H Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor MAG.T1.5_03151 330214.NIDE2551 0.0 1139.4 Nitrospirae lepA GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0006950,GO:0006970,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009268,GO:0009409,GO:0009628,GO:0009651,GO:0009987,GO:0010467,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0042802,GO:0043021,GO:0043023,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0050896,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K03596 ko05134,map05134 ko00000,ko00001 Bacteria 3J0D1@40117,COG0481@1,COG0481@2 NA|NA|NA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner MAG.T1.5_03152 330214.NIDE2552 2.8e-132 478.0 Nitrospirae 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 ko00000,ko00001,ko01000,ko01002 Bacteria 3J0IP@40117,COG0681@1,COG0681@2 NA|NA|NA U Signal peptidase, peptidase S26 MAG.T1.5_03153 330214.NIDE2553 5.3e-165 587.0 Nitrospirae rfaE 2.7.1.167,2.7.7.70 ko:K03272 ko00540,ko01100,map00540,map01100 M00064 R05644,R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 Bacteria 3J0GT@40117,COG2870@1,COG2870@2 NA|NA|NA M Phosphomethylpyrimidine kinase MAG.T1.5_03154 330214.NIDE2554 1.6e-124 452.2 Nitrospirae kdsB 2.7.7.38 ko:K00979 ko00540,ko01100,map00540,map01100 M00063 R03351,R11396 RC00152,RC00910 ko00000,ko00001,ko00002,ko01000,ko01005 Bacteria 3J0NR@40117,COG1212@1,COG1212@2 NA|NA|NA M Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria MAG.T1.5_03155 330214.NIDE2555 1.9e-305 1054.3 Nitrospirae pyrG GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1276,iECO103_1326.ECO103_3323,iNJ661.Rv1699,iPC815.YPO3377 Bacteria 3J0FB@40117,COG0504@1,COG0504@2 NA|NA|NA F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates MAG.T1.5_03156 330214.NIDE2556 4.8e-143 513.8 Nitrospirae kdsA 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 Bacteria 3J0AK@40117,COG2877@1,COG2877@2 NA|NA|NA M DAHP synthetase I family MAG.T1.5_03157 330214.NIDE2557 2.7e-159 568.2 Nitrospirae kdsD GO:0003674,GO:0003824,GO:0016853,GO:0016860,GO:0016861,GO:0019146 5.3.1.13 ko:K03281,ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 2.A.49 iAF987.Gmet_1278 Bacteria 3J0GG@40117,COG0517@1,COG0517@2,COG0794@1,COG0794@2 NA|NA|NA M Belongs to the SIS family. GutQ KpsF subfamily MAG.T1.5_03158 330214.NIDE2558 3.7e-92 344.4 Nitrospirae pgsA 2.7.8.5 ko:K00995 ko00564,ko01100,map00564,map01100 R01801 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 iIT341.HP1016 Bacteria 3J0NH@40117,COG0558@1,COG0558@2 NA|NA|NA I CDP-alcohol phosphatidyltransferase MAG.T1.5_03159 330214.NIDE2559 7.9e-95 353.2 Nitrospirae plsY 2.3.1.15 ko:K03977,ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004,ko03009 Bacteria 3J0PK@40117,COG0344@1,COG0344@2 NA|NA|NA I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP MAG.T1.5_03160 330214.NIDE2560 1.9e-86 325.5 Bacteria ko:K10716 ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 Bacteria COG0569@1,COG0569@2 NA|NA|NA P domain protein MAG.T1.5_03161 330214.NIDE2561 8.2e-228 796.2 Bacteria 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 Bacteria COG0265@1,COG0265@2 NA|NA|NA O serine-type endopeptidase activity MAG.T1.5_03162 330214.NIDE2562 0.0 1079.3 Nitrospirae fusA2 ko:K02355 ko00000,ko03012,ko03029 Bacteria 3J0WU@40117,COG0480@1,COG0480@2 NA|NA|NA J Elongation factor G, domain IV MAG.T1.5_03163 330214.NIDE2563 3.9e-117 427.6 Nitrospirae radC ko:K03630 ko00000 Bacteria 3J0HV@40117,COG2003@1,COG2003@2 NA|NA|NA E RadC-like JAB domain MAG.T1.5_03164 330214.NIDE2564 2.5e-25 120.6 Bacteria Bacteria 2EI4B@1,33BVP@2 NA|NA|NA MAG.T1.5_03165 330214.NIDE2565 1.9e-61 241.9 Nitrospirae rsmD GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052913,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.171 ko:K08316 R07234 RC00003 ko00000,ko01000,ko03009 Bacteria 3J0V5@40117,COG0742@1,COG0742@2 NA|NA|NA L Conserved hypothetical protein 95 MAG.T1.5_03166 330214.NIDE2566 5.1e-84 317.0 Nitrospirae coaD GO:0003674,GO:0003824,GO:0004595,GO:0006082,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0051186,GO:0051188,GO:0070566,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0MF@40117,COG0669@1,COG0669@2 NA|NA|NA F Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate MAG.T1.5_03167 330214.NIDE2567 5.2e-207 726.9 Nitrospirae aspB GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769,GO:0047297 2.6.1.1,2.6.1.14 ko:K00812,ko:K22457 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 R00355,R00694,R00734,R00896,R01346,R02433,R02619,R05052 RC00006,RC00025 ko00000,ko00001,ko01000,ko01007 iHN637.CLJU_RS06550 Bacteria 3J0EV@40117,COG0436@1,COG0436@2 NA|NA|NA E Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_03168 330214.NIDE2568 7.6e-35 153.3 Nitrospirae Bacteria 3J0V8@40117,COG2331@1,COG2331@2 NA|NA|NA S Putative regulatory protein MAG.T1.5_03170 330214.NIDE2572 7e-73 280.4 Nitrospirae prmC 2.7.7.87 ko:K07566 R10463 RC00745 ko00000,ko01000,ko03009,ko03016 Bacteria 3J0TD@40117,COG0009@1,COG0009@2 NA|NA|NA J Telomere recombination MAG.T1.5_03171 330214.NIDE2573 3.6e-214 750.7 Nitrospirae purD 6.3.2.6,6.3.4.13,6.3.5.3 ko:K01945,ko:K01952,ko:K13713 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144,R04463,R04591 RC00010,RC00064,RC00090,RC00162,RC00166,RC01160 ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS05245,iYO844.BSU06530 Bacteria 3J0H5@40117,COG0151@1,COG0151@2 NA|NA|NA F Phosphoribosylglycinamide synthetase, C domain MAG.T1.5_03172 330214.NIDE2574 9.3e-281 972.2 Nitrospirae purH GO:0003674,GO:0003824,GO:0004643,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 iEcHS_1320.EcHS_A4240,iPC815.YPO3728 Bacteria 3J0CV@40117,COG0138@1,COG0138@2 NA|NA|NA F AICARFT/IMPCHase bienzyme MAG.T1.5_03173 330214.NIDE2575 4.1e-116 424.5 Bacteria ko:K02051,ko:K03286 M00188 ko00000,ko00002,ko02000 1.B.6,3.A.1.16,3.A.1.17 Bacteria COG2885@1,COG2885@2 NA|NA|NA M chlorophyll binding MAG.T1.5_03174 330214.NIDE2576 5e-152 544.3 Bacteria ko:K00185,ko:K02967 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 5.A.3 Bacteria COG1196@1,COG1196@2,COG3743@1,COG3743@2 NA|NA|NA S rRNA binding MAG.T1.5_03175 247490.KSU1_C0782 3.3e-130 471.9 Planctomycetes Bacteria 2J09P@203682,COG3319@1,COG3319@2 NA|NA|NA Q amino acid activation for nonribosomal peptide biosynthetic process MAG.T1.5_03176 247490.KSU1_C0781 1.7e-161 576.2 Bacteria Bacteria COG1404@1,COG1404@2 NA|NA|NA O Belongs to the peptidase S8 family MAG.T1.5_03178 330214.NIDE2577 2.5e-121 442.2 Bacteria ko:K07234 ko00000 Bacteria COG3213@1,COG3213@2 NA|NA|NA P Protein involved in response to NO MAG.T1.5_03179 330214.NIDE2578 1.9e-105 389.0 Bacteria Bacteria 2F9RH@1,3421I@2 NA|NA|NA MAG.T1.5_03180 330214.NIDE2581 0.0 1116.3 Bacteria Bacteria COG0683@1,COG0683@2 NA|NA|NA E ABC-type branched-chain amino acid transport systems, periplasmic component MAG.T1.5_03181 1267535.KB906767_gene732 2.1e-34 151.8 Bacteria Bacteria COG1873@1,COG1873@2 NA|NA|NA S PRC-barrel domain MAG.T1.5_03183 1267535.KB906767_gene1580 2.4e-14 85.9 Bacteria MA20_17390 ko:K00713,ko:K06338 ko00000,ko01000,ko01003,ko01005 Bacteria COG0438@1,COG0438@2 NA|NA|NA M transferase activity, transferring glycosyl groups MAG.T1.5_03184 330214.NIDE1784 2.5e-101 375.2 Bacteria Bacteria COG0500@1,COG2226@2 NA|NA|NA Q methyltransferase MAG.T1.5_03187 338963.Pcar_1976 4.9e-102 378.3 Desulfuromonadales Bacteria 1N5Z3@1224,2CGDQ@1,2WVDK@28221,32VRQ@2,43057@68525,43V2T@69541 NA|NA|NA MAG.T1.5_03188 330214.NIDE3247 2.5e-52 212.2 Bacteria ko:K02282 ko00000,ko02035,ko02044 Bacteria COG2197@1,COG2197@2 NA|NA|NA K response regulator MAG.T1.5_03189 330214.NIDE3247 3.9e-47 194.9 Bacteria ko:K02282 ko00000,ko02035,ko02044 Bacteria COG2197@1,COG2197@2 NA|NA|NA K response regulator MAG.T1.5_03190 215803.DB30_2740 4.1e-49 201.4 Myxococcales sodA 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 ko00000,ko00001,ko01000 Bacteria 1R4Z3@1224,2WMPC@28221,2YVDJ@29,42QV7@68525,COG0605@1,COG0605@2 NA|NA|NA C Iron/manganese superoxide dismutases, C-terminal domain MAG.T1.5_03192 1282360.ABAC460_19100 4e-12 78.2 Caulobacterales Bacteria 1NMH1@1224,2KGWZ@204458,2U9D8@28211,COG0517@1,COG0517@2 NA|NA|NA S CBS domain MAG.T1.5_03194 402626.Rpic_0139 2.5e-63 248.4 Burkholderiaceae bfr GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008150,GO:0009987,GO:0019725,GO:0030003,GO:0042592,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0097577,GO:0098771 1.16.3.1 ko:K03594 ko00860,map00860 R00078 RC02758 ko00000,ko00001,ko01000 Bacteria 1K074@119060,1RAQ8@1224,2VQHR@28216,COG2193@1,COG2193@2 NA|NA|NA P Ferritin, Dps family protein MAG.T1.5_03195 247490.KSU1_B0323 1.8e-290 1005.0 Planctomycetes glgX 3.2.1.196,3.2.1.68 ko:K01214,ko:K02438 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02111,R09995,R11261 ko00000,ko00001,ko00002,ko01000 CBM48,GH13 Bacteria 2IX65@203682,COG1523@1,COG1523@2 NA|NA|NA G Carbohydrate-binding module 48 (Isoamylase N-terminal domain) MAG.T1.5_03197 93220.LV28_20185 2.2e-16 91.3 Burkholderiaceae Bacteria 1K9H1@119060,1N6X4@1224,2VW2V@28216,COG3237@1,COG3237@2 NA|NA|NA S Belongs to the UPF0337 (CsbD) family MAG.T1.5_03199 1177928.TH2_03895 1.2e-15 89.4 Rhodospirillales yjbJ Bacteria 1N6X4@1224,2JU6A@204441,2UF5Q@28211,COG3237@1,COG3237@2 NA|NA|NA S CsbD-like MAG.T1.5_03201 690850.Desaf_1404 3.1e-62 245.7 Deltaproteobacteria GO:0003674,GO:0003824,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0009987,GO:0010333,GO:0016829,GO:0016835,GO:0016838,GO:0042214,GO:0044237,GO:0044238,GO:0044255,GO:0071704 4.2.3.118 ko:K16218 ko00000,ko01000 Bacteria 1QDEM@1224,2WVWF@28221,430CM@68525,COG3170@1,COG3170@2 NA|NA|NA NU Protein of unknown function (DUF1207) MAG.T1.5_03204 631362.Thi970DRAFT_01557 3.5e-68 266.9 Proteobacteria ydfH 2.7.13.3 ko:K07675,ko:K07814,ko:K11623 ko02020,map02020 M00473,M00484 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 1R7HC@1224,COG2197@1,COG2197@2,COG2199@1,COG2202@1,COG2202@2,COG3706@2,COG4585@1,COG4585@2 NA|NA|NA T Diguanylate cyclase MAG.T1.5_03205 1380355.JNIJ01000028_gene716 4.7e-72 279.3 Bradyrhizobiaceae exsG 2.1.1.80,3.1.1.61 ko:K13924 ko02020,ko02030,map02020,map02030 M00506 ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 Bacteria 1NWNJ@1224,2TZ8H@28211,3JXDQ@41294,COG2202@1,COG2202@2,COG2203@1,COG2203@2,COG2461@1,COG2461@2,COG3920@1,COG3920@2 NA|NA|NA T Histidine kinase-like ATPase domain MAG.T1.5_03206 631362.Thi970DRAFT_01557 2.1e-65 257.3 Proteobacteria ydfH 2.7.13.3 ko:K07675,ko:K07814,ko:K11623 ko02020,map02020 M00473,M00484 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 1R7HC@1224,COG2197@1,COG2197@2,COG2199@1,COG2202@1,COG2202@2,COG3706@2,COG4585@1,COG4585@2 NA|NA|NA T Diguanylate cyclase MAG.T1.5_03207 1210884.HG799463_gene9352 2.2e-52 212.2 Planctomycetes cheB 3.1.1.61,3.5.1.44 ko:K03412,ko:K03413 ko02020,ko02030,map02020,map02030 M00506 ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 Bacteria 2IZA0@203682,COG2201@1,COG2201@2 NA|NA|NA NT CheB methylesterase MAG.T1.5_03208 1210884.HG799463_gene9351 8.6e-111 406.8 Planctomycetes cheR 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 ko00000,ko00001,ko01000,ko02035 Bacteria 2IXV1@203682,COG1352@1,COG1352@2 NA|NA|NA NT Methyltransferase, chemotaxis proteins MAG.T1.5_03209 1210884.HG799463_gene9350 2.2e-289 1001.9 Planctomycetes Bacteria 2IXNT@203682,COG0745@1,COG0745@2,COG2199@1,COG3706@2,COG4251@1,COG4251@2 NA|NA|NA T CHASE3 domain MAG.T1.5_03210 1173026.Glo7428_2092 1.3e-248 867.1 Cyanobacteria ko:K07814 ko00000,ko02022 Bacteria 1G09B@1117,COG0642@1,COG0745@1,COG0745@2,COG0784@1,COG0784@2,COG2202@1,COG2202@2,COG2203@1,COG2203@2,COG2205@2 NA|NA|NA T PhoQ Sensor MAG.T1.5_03213 472759.Nhal_1635 3.7e-177 628.6 Chromatiales 3.1.4.4 ko:K01115 ko00564,ko00565,ko01100,ko01110,ko04014,ko04024,ko04071,ko04072,ko04144,ko04666,ko04724,ko04912,ko05231,map00564,map00565,map01100,map01110,map04014,map04024,map04071,map04072,map04144,map04666,map04724,map04912,map05231 R01310,R02051,R07385 RC00017,RC00425 ko00000,ko00001,ko01000,ko04131 Bacteria 1MV8I@1224,1RSB6@1236,1WXPA@135613,COG0398@1,COG0398@2,COG1502@1,COG1502@2 NA|NA|NA I PFAM SNARE associated Golgi protein MAG.T1.5_03214 1266925.JHVX01000002_gene813 2.3e-56 225.7 Nitrosomonadales Bacteria 1MVN7@1224,2VQ9I@28216,371PA@32003,COG3568@1,COG3568@2 NA|NA|NA L Endonuclease/Exonuclease/phosphatase family MAG.T1.5_03217 795666.MW7_0150 2.1e-17 96.7 Burkholderiaceae Bacteria 1K3XE@119060,1RDKU@1224,2DMIH@1,2VR1F@28216,32RT1@2 NA|NA|NA MAG.T1.5_03218 1502852.FG94_01041 3.2e-11 73.9 Oxalobacteraceae ku GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0097159,GO:1901363 ko:K10979 ko03450,map03450 ko00000,ko00001,ko03400 Bacteria 1N4UX@1224,2VJE3@28216,472N1@75682,COG1273@1,COG1273@2 NA|NA|NA L With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD MAG.T1.5_03220 234267.Acid_0218 1.6e-197 696.0 Acidobacteria treZ-2 3.2.1.141 ko:K01236 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11256 RC00049 ko00000,ko00001,ko00002,ko01000 CBM48,GH13 Bacteria 3Y33J@57723,COG0296@1,COG0296@2 NA|NA|NA G TIGRFAM malto-oligosyltrehalose trehalohydrolase MAG.T1.5_03221 1254432.SCE1572_41890 8e-175 620.5 Myxococcales Bacteria 1MW01@1224,2WJF7@28221,2YX9T@29,42NSN@68525,COG3408@1,COG3408@2 NA|NA|NA G High confidence in function and specificity MAG.T1.5_03222 395019.Bmul_6253 5e-13 80.5 Burkholderiaceae ligD 6.5.1.1 ko:K01971 ko03450,map03450 R00381 RC00005 ko00000,ko00001,ko01000,ko03400 Bacteria 1KBUI@119060,1QDD9@1224,2WE5T@28216,COG1793@1,COG1793@2 NA|NA|NA L ATP dependent DNA ligase C terminal region MAG.T1.5_03224 221288.JH992900_gene319 3.8e-47 194.1 Stigonemataceae M1-951 Bacteria 1G65D@1117,1JKYE@1189,COG4288@1,COG4288@2 NA|NA|NA S Anabaena sensory rhodopsin transducer MAG.T1.5_03225 204669.Acid345_2151 4.2e-229 800.8 Acidobacteriia spxB 1.2.3.3,1.2.5.1 ko:K00156,ko:K00158 ko00620,ko01100,map00620,map01100 R00207,R03145 RC00860,RC02745 ko00000,ko00001,ko01000 iSB619.SA_RS13340 Bacteria 2JITT@204432,3Y3QI@57723,COG0028@1,COG0028@2 NA|NA|NA EH Belongs to the TPP enzyme family MAG.T1.5_03226 472759.Nhal_2852 1.1e-76 293.9 Bacteria tqsA ko:K03548 ko00000,ko02000 2.A.86.1 Bacteria COG0628@1,COG0628@2 NA|NA|NA D permease MAG.T1.5_03227 316067.Geob_2601 2.9e-59 235.7 Desulfuromonadales rbn ko:K03466,ko:K07058 ko00000,ko03036 3.A.12 Bacteria 1MXQA@1224,2X2G7@28221,437BB@68525,43V98@69541,COG1295@1,COG1295@2 NA|NA|NA S Virulence factor BrkB MAG.T1.5_03233 292415.Tbd_2258 1.9e-107 396.0 Hydrogenophilales gfo 1.1.99.28 ko:K00118 ko00000,ko01000 Bacteria 1KTHN@119069,1PF0E@1224,2W9B2@28216,COG0673@1,COG0673@2 NA|NA|NA S Oxidoreductase family, NAD-binding Rossmann fold MAG.T1.5_03236 1123376.AUIU01000016_gene234 5.8e-09 67.0 Bacteria ko:K04065 ko00000 Bacteria COG2823@1,COG2823@2 NA|NA|NA S hyperosmotic response MAG.T1.5_03238 63737.Npun_R3103 1.5e-112 412.9 Nostocales yxnA Bacteria 1GQ39@1117,1HREB@1161,COG4221@1,COG4221@2 NA|NA|NA S Enoyl-(Acyl carrier protein) reductase MAG.T1.5_03240 1279009.ADICEAN_02250 9.1e-19 99.8 Cytophagia 2.3.1.94,5.1.3.2 ko:K01784,ko:K10817,ko:K12443,ko:K15672 ko00052,ko00520,ko00522,ko01051,ko01052,ko01100,ko01130,map00052,map00520,map00522,map01051,map01052,map01100,map01130 M00361,M00362,M00632,M00774 R00291,R00918,R02984 RC00004,RC00289,RC02825,RC02826,RC02828,RC02829,RC02830,RC02831 ko00000,ko00001,ko00002,ko01000,ko01004,ko01008 Bacteria 47W2D@768503,4NVIQ@976,COG0451@1,COG0451@2 NA|NA|NA GM SPW repeat MAG.T1.5_03241 1185876.BN8_06419 4.1e-59 234.6 Cytophagia 4.1.1.35 ko:K00754,ko:K08678,ko:K13613 ko00520,ko01100,map00520,map01100 M00361 R01384 RC00508 ko00000,ko00001,ko00002,ko01000,ko01004,ko01008 GT4 Bacteria 47P8P@768503,4NN4T@976,COG0451@1,COG0451@2 NA|NA|NA GM Vitamin K epoxide reductase family MAG.T1.5_03242 330214.NIDE2609 5.4e-131 474.2 Nitrospirae cydB GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0016682,GO:0019646,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0070069,GO:0071944,GO:0097159,GO:1901363 1.10.3.14 ko:K00426 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 iECABU_c1320.ECABU_c10120,iLF82_1304.LF82_0101,iNRG857_1313.NRG857_04455,iPC815.YPO1118,ic_1306.c1120 Bacteria 3J0M4@40117,COG1294@1,COG1294@2 NA|NA|NA C Cytochrome bd terminal oxidase subunit II MAG.T1.5_03243 330214.NIDE2610 3.8e-214 750.7 Nitrospirae 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 Bacteria 3J0HH@40117,COG1271@1,COG1271@2 NA|NA|NA C Cytochrome bd terminal oxidase subunit I MAG.T1.5_03245 330214.NIDE1790 2.5e-61 242.3 Bacteria ko:K20276 ko02024,map02024 ko00000,ko00001 Bacteria COG4733@1,COG4733@2 NA|NA|NA S cellulase activity MAG.T1.5_03246 330214.NIDE1793 3.8e-153 547.7 Bacteria ompT GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009279,GO:0016020,GO:0016787,GO:0017171,GO:0019538,GO:0019867,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031975,GO:0043170,GO:0044238,GO:0044425,GO:0044462,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564 3.4.23.48,3.4.23.49 ko:K01355,ko:K08477,ko:K08566,ko:K13520 ko01503,ko02020,map01503,map02020 M00744 ko00000,ko00001,ko00002,ko01000,ko01002,ko01504 Bacteria COG4571@1,COG4571@2 NA|NA|NA M Outer membrane protease MAG.T1.5_03248 330214.NIDE1794 1.5e-173 615.5 Bacteria helY GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575 ko:K03727 ko00000,ko01000 Bacteria COG4581@1,COG4581@2 NA|NA|NA L dead DEAH box helicase MAG.T1.5_03249 330214.NIDE1795 0.0 1104.0 Bacteria helY GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575 ko:K03727 ko00000,ko01000 Bacteria COG4581@1,COG4581@2 NA|NA|NA L dead DEAH box helicase MAG.T1.5_03250 330214.NIDE1796 1e-205 722.6 Nitrospirae glgC GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008878,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0070566,GO:0071704,GO:1901576 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0BI@40117,COG0448@1,COG0448@2 NA|NA|NA H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans MAG.T1.5_03252 330214.NIDE1798 1.4e-164 585.9 Bacteria potA 3.6.3.31 ko:K11072 ko02010,map02010 M00299 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.11.1 Bacteria COG3842@1,COG3842@2 NA|NA|NA P ATPase activity MAG.T1.5_03253 330214.NIDE1799 9.8e-126 456.4 Bacteria potB ko:K11071 ko02010,map02010 M00299 ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 Bacteria COG1176@1,COG1176@2 NA|NA|NA P putrescine transport MAG.T1.5_03254 330214.NIDE1800 2.8e-108 398.3 Bacteria potC ko:K11070 ko02010,map02010 M00299 ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 Bacteria COG1177@1,COG1177@2 NA|NA|NA P DNA import into cell involved in transformation MAG.T1.5_03255 330214.NIDE1801 3.6e-167 594.3 Bacteria potD ko:K11069,ko:K11070 ko02010,map02010 M00299 ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 iSB619.SA_RS05395 Bacteria COG0687@1,COG0687@2 NA|NA|NA E Required for the activity of the bacterial periplasmic transport system of putrescine MAG.T1.5_03256 330214.NIDE1802 6.5e-209 733.4 Nitrospirae czcC ko:K15725 ko00000,ko02000 1.B.17.2.2 Bacteria 3J1F2@40117,COG1538@1,COG1538@2 NA|NA|NA MU Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_03257 330214.NIDE1803 3.3e-174 617.8 Bacteria ko:K15727 ko00000,ko02000 8.A.1.2.1 Bacteria COG0845@1,COG0845@2 NA|NA|NA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family MAG.T1.5_03258 330214.NIDE1805 1.3e-116 426.0 Bacteria Bacteria COG1413@1,COG1413@2 NA|NA|NA C deoxyhypusine monooxygenase activity MAG.T1.5_03259 330214.NIDE1806 3.8e-93 347.4 Nitrospirae def2 GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.88 ko:K01462 ko00000,ko01000 Bacteria 3J146@40117,COG0242@1,COG0242@2 NA|NA|NA J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions MAG.T1.5_03260 330214.NIDE1807 2e-292 1011.1 Nitrospirae mdlB ko:K06147,ko:K11085 ko02010,map02010 ko00000,ko00001,ko01000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 3J0X8@40117,COG1132@1,COG1132@2 NA|NA|NA V Evidence 2a Function of homologous gene experimentally demonstrated in an other organism MAG.T1.5_03264 330214.NIDE1815 1.2e-88 332.4 Nitrospirae mec 3.13.1.6 ko:K21140 ko04122,map04122 R11524 RC00064,RC00090 ko00000,ko00001,ko01000 Bacteria 3J0U8@40117,COG1310@1,COG1310@2 NA|NA|NA S JAB/MPN domain MAG.T1.5_03265 330214.NIDE1816 1.9e-144 518.5 Nitrospirae moeB 2.7.7.80 ko:K21029 ko04122,map04122 R07459 RC00043 ko00000,ko00001,ko01000 Bacteria 3J0X5@40117,COG0476@1,COG0476@2 NA|NA|NA H ThiF family MAG.T1.5_03266 330214.NIDE1817 5.1e-37 159.8 Nitrospirae ko:K02071 ko02010,map02010 M00238 ko00000,ko00001,ko00002,ko02000 3.A.1.24 Bacteria 3J0VT@40117,COG1135@1,COG1135@2 NA|NA|NA P NIL MAG.T1.5_03267 330214.NIDE1818 5.4e-43 179.9 Nitrospirae 2.7.7.80,2.8.1.11 ko:K03636,ko:K21147 ko04122,map04122 R07459,R07461 RC00043 ko00000,ko00001,ko01000 Bacteria 3J0T2@40117,COG1977@1,COG1977@2 NA|NA|NA H ThiS family MAG.T1.5_03268 330214.NIDE1819 3.3e-231 807.4 Nitrospirae thrC1 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0FZ@40117,COG0498@1,COG0498@2 NA|NA|NA E Pyridoxal-phosphate dependent enzyme MAG.T1.5_03269 330214.NIDE1820 2.1e-146 525.0 Nitrospirae moeB 2.7.7.80 ko:K21029 ko04122,map04122 R07459 RC00043 ko00000,ko00001,ko01000 iIT341.HP0814 Bacteria 3J0WD@40117,COG0476@1,COG0476@2 NA|NA|NA H ThiF family MAG.T1.5_03270 330214.NIDE1821 9.2e-167 592.8 Nitrospirae cysK-1 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0HD@40117,COG0031@1,COG0031@2 NA|NA|NA E Pyridoxal-phosphate dependent enzyme MAG.T1.5_03271 330214.NIDE1822 1.4e-27 128.3 Bacteria thiS ko:K03154 ko04122,map04122 ko00000,ko00001 Bacteria COG2104@1,COG2104@2 NA|NA|NA H thiamine diphosphate biosynthetic process MAG.T1.5_03273 330214.NIDE1825 2e-81 308.5 Nitrospirae nuc 3.1.4.4 ko:K06131,ko:K17717 ko00564,ko00565,ko01100,ko01110,map00564,map00565,map01100,map01110 R01310,R02051,R07385,R07390 RC00017,RC00425 ko00000,ko00001,ko01000 Bacteria 3J1DV@40117,COG1502@1,COG1502@2 NA|NA|NA I PLD-like domain MAG.T1.5_03274 330214.NIDE1826 1.3e-211 742.3 Nitrospirae MA20_30655 1.14.13.232 ko:K14253 ko00253,ko01057,ko01130,map00253,map01057,map01130 M00780,M00823 R05463 RC00236 ko00000,ko00001,ko00002,ko01000 Bacteria 3J16C@40117,COG0654@1,COG0654@2 NA|NA|NA C FAD binding domain MAG.T1.5_03275 330214.NIDE1827 1.4e-120 439.1 Bacteria ant1 2.7.7.47 ko:K00984,ko:K19279 ko00000,ko01000,ko01504 Bacteria COG1708@1,COG1708@2 NA|NA|NA S nucleotidyltransferase activity MAG.T1.5_03276 330214.NIDE1828 3.6e-110 404.4 Bacteria ko:K06872 ko00000 Bacteria COG1512@1,COG1512@2 NA|NA|NA S TPM domain MAG.T1.5_03278 330214.NIDE1836 4.5e-43 180.6 Bacteria 5.3.3.1 ko:K01822 ko00140,ko00984,ko01100,ko01120,map00140,map00984,map01100,map01120 M00107,M00110 R01837,R02216,R02499,R02840,R03327,R04163,R04678,R04849,R09955 RC00146,RC00762 ko00000,ko00001,ko00002,ko01000 Bacteria COG3631@1,COG3631@2 NA|NA|NA S light absorption MAG.T1.5_03279 330214.NIDE1844 1.9e-58 232.3 Bacteria ko:K11932 ko00000 Bacteria COG0589@1,COG0589@2 NA|NA|NA T AMP binding MAG.T1.5_03280 330214.NIDE1847 2.8e-57 228.0 Nitrospirae Bacteria 2DQ7E@1,3353C@2,3J1EM@40117 NA|NA|NA S Domain of unknown function (DUF5069) MAG.T1.5_03281 330214.NIDE1848 2.1e-112 411.8 Bacteria Bacteria COG3055@1,COG3055@2 NA|NA|NA G Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses MAG.T1.5_03283 330214.NIDE1850 3.4e-43 180.6 Bacteria clpS GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0050896,GO:0051087 ko:K06891 ko00000 Bacteria COG2127@1,COG2127@2 NA|NA|NA T Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation MAG.T1.5_03286 330214.NIDE1853 1.6e-150 539.3 Nitrospirae Bacteria 3J10W@40117,COG0635@1,COG0635@2 NA|NA|NA H Elongator protein 3, MiaB family, Radical SAM MAG.T1.5_03288 330214.NIDE1855 5.5e-33 146.4 Bacteria Bacteria COG2331@1,COG2331@2 NA|NA|NA P Regulatory protein, FmdB family MAG.T1.5_03291 330214.NIDE1229 1.1e-38 166.8 Bacteria 3.1.3.3 ko:K03413,ko:K07315 ko02020,ko02030,map02020,map02030 M00506 ko00000,ko00001,ko00002,ko01000,ko02022,ko02035,ko03021 Bacteria COG3437@1,COG3437@2 NA|NA|NA T response regulator, receiver MAG.T1.5_03292 330214.NIDE1859 9.3e-61 240.4 Bacteria rcsD GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009927,GO:0009987,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0031224,GO:0031226,GO:0035556,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.7.13.3 ko:K07676,ko:K10715,ko:K20976 ko02020,ko02024,ko02025,ko02026,map02020,map02024,map02025,map02026 M00474,M00517,M00820 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria COG0784@1,COG0784@2,COG2198@1,COG2198@2 NA|NA|NA T Histidine kinase MAG.T1.5_03293 330214.NIDE1860 3e-138 498.0 Nitrospirae Bacteria 3J14J@40117,COG1262@1,COG1262@2 NA|NA|NA S Evidence 4 Homologs of previously reported genes of MAG.T1.5_03294 330214.NIDE1861 1.2e-124 452.6 Bacteria 1.3.3.11 ko:K06137 ko00000,ko01000 Bacteria COG5424@1,COG5424@2 NA|NA|NA H Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ MAG.T1.5_03295 330214.NIDE1862 3e-44 184.1 Nitrospirae Bacteria 2CC8H@1,330SM@2,3J1D6@40117 NA|NA|NA MAG.T1.5_03299 330214.NIDE1867 1.3e-121 442.6 Bacteria Bacteria 2FKUS@1,34CF5@2 NA|NA|NA MAG.T1.5_03300 330214.NIDE1868 0.0 2238.4 Nitrospirae metH GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 iECO103_1326.ECO103_4764,iECUMN_1333.ECUMN_4545 Bacteria 3J0UH@40117,COG0646@1,COG0646@2,COG1410@1,COG1410@2 NA|NA|NA H Pterin binding enzyme MAG.T1.5_03302 330214.NIDE1870 3.9e-207 727.2 Nitrospirae ko:K07814 ko00000,ko02022 Bacteria 3J0ID@40117,COG3437@1,COG3437@2 NA|NA|NA T response regulator MAG.T1.5_03304 330214.NIDE1871 1.2e-129 469.2 Nitrospirae rph GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006401,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043170,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:1901361,GO:1901575 2.7.7.56,3.6.1.66 ko:K00989,ko:K02428 ko00230,map00230 R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000,ko03016 Bacteria 3J0B8@40117,COG0689@1,COG0689@2 NA|NA|NA J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates MAG.T1.5_03307 330214.NIDE1294 1.3e-38 165.2 Nitrospirae tuf ko:K02358 ko00000,ko03012,ko03029,ko04147 Bacteria 3J0DG@40117,COG0050@1,COG0050@2 NA|NA|NA J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis MAG.T1.5_03308 330214.NIDE1310 1.3e-48 198.7 Nitrospirae rpsJ GO:0001072,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006355,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0015935,GO:0019219,GO:0019222,GO:0019538,GO:0022626,GO:0022627,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043244,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0140110,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2001141 ko:K02946 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0P3@40117,COG0051@1,COG0051@2 NA|NA|NA J Involved in the binding of tRNA to the ribosomes MAG.T1.5_03309 330214.NIDE1311 3.9e-105 387.5 Nitrospirae rplC GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010604,GO:0010628,GO:0015934,GO:0016020,GO:0016043,GO:0019219,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0031323,GO:0031325,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000232,GO:2000234 ko:K02906 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0HP@40117,COG0087@1,COG0087@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit MAG.T1.5_03310 330214.NIDE1312 2.5e-91 341.7 Nitrospirae rplD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02926 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J15W@40117,COG0088@1,COG0088@2 NA|NA|NA J Ribosomal protein L4/L1 family MAG.T1.5_03311 330214.NIDE1313 7.1e-41 172.9 Nitrospirae rplW GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02892 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0TP@40117,COG0089@1,COG0089@2 NA|NA|NA J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome MAG.T1.5_03312 330214.NIDE1314 3.7e-143 514.2 Nitrospirae rplB GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02886 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0BX@40117,COG0090@1,COG0090@2 NA|NA|NA J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity MAG.T1.5_03313 330214.NIDE1315 1e-47 195.7 Nitrospirae rpsS GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02965 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0MU@40117,COG0185@1,COG0185@2 NA|NA|NA J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA MAG.T1.5_03314 330214.NIDE1316 7.5e-53 213.0 Nitrospirae rplV GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042788,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02890 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0RZ@40117,COG0091@1,COG0091@2 NA|NA|NA J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome MAG.T1.5_03315 330214.NIDE1317 3e-119 434.5 Nitrospirae rpsC GO:0000028,GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02982 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0AP@40117,COG0092@1,COG0092@2 NA|NA|NA J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation MAG.T1.5_03316 330214.NIDE1318 1.1e-62 245.7 Nitrospirae rplP GO:0000027,GO:0000049,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02878 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0H7@40117,COG0197@1,COG0197@2 NA|NA|NA J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs MAG.T1.5_03317 330214.NIDE1319 1.3e-23 115.2 Bacteria rpmC GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02904 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria COG0255@1,COG0255@2 NA|NA|NA J Belongs to the universal ribosomal protein uL29 family MAG.T1.5_03318 330214.NIDE1320 2.3e-38 164.5 Nitrospirae rpsQ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02961 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0TQ@40117,COG0186@1,COG0186@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA MAG.T1.5_03319 330214.NIDE1321 3.2e-62 244.2 Nitrospirae rplN GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071944,GO:0097159,GO:1901363,GO:1990904 ko:K02874 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0JD@40117,COG0093@1,COG0093@2 NA|NA|NA J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome MAG.T1.5_03320 330214.NIDE1322 3.3e-47 194.1 Nitrospirae rplX GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02895 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0VK@40117,COG0198@1,COG0198@2 NA|NA|NA J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit MAG.T1.5_03321 330214.NIDE1323 2.2e-98 365.2 Nitrospirae rplE GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02931 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0HN@40117,COG0094@1,COG0094@2 NA|NA|NA J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits MAG.T1.5_03322 330214.NIDE1325 9.9e-62 242.7 Nitrospirae rpsH GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 ko:K02994 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0SJ@40117,COG0096@1,COG0096@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit MAG.T1.5_03323 330214.NIDE1326 7.1e-78 296.6 Nitrospirae rplF GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02933 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0JB@40117,COG0097@1,COG0097@2 NA|NA|NA J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center MAG.T1.5_03324 330214.NIDE1327 3.8e-52 210.7 Nitrospirae rplR GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02881 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0QF@40117,COG0256@1,COG0256@2 NA|NA|NA J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance MAG.T1.5_03325 330214.NIDE1328 3.4e-83 314.3 Nitrospirae rpsE GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990145,GO:1990904 ko:K02988 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0M3@40117,COG0098@1,COG0098@2 NA|NA|NA J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body MAG.T1.5_03326 330214.NIDE1329 9e-22 109.0 Bacteria rpmD GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02907 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria COG1841@1,COG1841@2 NA|NA|NA J maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) MAG.T1.5_03327 330214.NIDE1330 5.7e-43 179.9 Nitrospirae rplO GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02876 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0PY@40117,COG0200@1,COG0200@2 NA|NA|NA J binds to the 23S rRNA MAG.T1.5_03328 330214.NIDE1331 3.6e-241 840.5 Nitrospirae secY GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5 Bacteria 3J0C0@40117,COG0201@1,COG0201@2 NA|NA|NA U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently MAG.T1.5_03329 330214.NIDE1332 9.5e-94 349.7 Nitrospirae adk GO:0003674,GO:0003824,GO:0004017,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 iHN637.CLJU_RS20110 Bacteria 3J0K3@40117,COG0563@1,COG0563@2 NA|NA|NA F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism MAG.T1.5_03330 330214.NIDE1333 4.1e-125 454.1 Nitrospirae map 3.4.11.18 ko:K01265 ko00000,ko01000,ko01002 Bacteria 3J0GR@40117,COG0024@1,COG0024@2 NA|NA|NA J Metallopeptidase family M24 MAG.T1.5_03331 330214.NIDE1334 3.7e-34 150.2 Nitrospirae infA GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009986,GO:0030246,GO:0030247,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:2001065 ko:K02518 ko00000,ko03012 Bacteria 3J0QB@40117,COG0361@1,COG0361@2 NA|NA|NA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex MAG.T1.5_03332 330214.NIDE1336 1.3e-58 232.3 Nitrospirae rpsM GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02952 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0Q5@40117,COG0099@1,COG0099@2 NA|NA|NA J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits MAG.T1.5_03333 330214.NIDE1337 1.9e-62 245.0 Nitrospirae rpsK GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02948 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0KE@40117,COG0100@1,COG0100@2 NA|NA|NA J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome MAG.T1.5_03334 330214.NIDE1338 1.3e-111 409.1 Nitrospirae rpsD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0016020,GO:0019222,GO:0019843,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 ko:K02986 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0IC@40117,COG0522@1,COG0522@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit MAG.T1.5_03335 330214.NIDE1339 6.6e-179 633.3 Nitrospirae rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 Bacteria 3J0AR@40117,COG0202@1,COG0202@2 NA|NA|NA K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates MAG.T1.5_03336 330214.NIDE1340 1.1e-61 242.7 Nitrospirae rplQ GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02879,ko:K16193 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0TE@40117,COG0203@1,COG0203@2 NA|NA|NA J Ribosomal protein L17 MAG.T1.5_03337 330214.NIDE1341 1.9e-93 348.6 Bacteria ko:K11719 ko00000,ko02000 1.B.42.1 Bacteria COG5375@1,COG5375@2 NA|NA|NA S Protein conserved in bacteria MAG.T1.5_03338 330214.NIDE1342 2.9e-60 238.4 Nitrospirae lptA GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0009279,GO:0010876,GO:0015920,GO:0016020,GO:0017089,GO:0019867,GO:0030288,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0042597,GO:0042802,GO:0044462,GO:0044464,GO:0046836,GO:0051179,GO:0051234,GO:0071702,GO:0071944,GO:1901264 ko:K09774 ko00000,ko02000 1.B.42.1 iB21_1397.B21_03016,iECBD_1354.ECBD_0542,iECB_1328.ECB_03065,iECD_1391.ECD_03065 Bacteria 3J1EG@40117,COG1934@1,COG1934@2 NA|NA|NA S OstA-like protein MAG.T1.5_03339 330214.NIDE1343 9e-123 446.4 Nitrospirae lptB GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 ko:K01990,ko:K06861 ko02010,map02010 M00254,M00320 ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1,3.A.1 Bacteria 3J0GJ@40117,COG1137@1,COG1137@2 NA|NA|NA S ABC transporter MAG.T1.5_03340 330214.NIDE1344 8.5e-263 912.5 Nitrospirae rpoN ko:K03092 ko02020,ko05111,map02020,map05111 ko00000,ko00001,ko03021 Bacteria 3J0AT@40117,COG1508@1,COG1508@2 NA|NA|NA K Sigma-54 factor, Activator interacting domain (AID) MAG.T1.5_03341 330214.NIDE1345 1.5e-79 302.4 Nitrospirae hpf GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0016020,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1990904,GO:2000112,GO:2000113 ko:K05808 ko00000,ko03009 Bacteria 3J0V7@40117,COG1544@1,COG1544@2 NA|NA|NA J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase MAG.T1.5_03342 330214.NIDE1346 4.7e-149 533.9 Nitrospirae rapZ GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363 ko:K06958 ko00000,ko03019 Bacteria 3J0IK@40117,COG1660@1,COG1660@2 NA|NA|NA S Displays ATPase and GTPase activities MAG.T1.5_03343 330214.NIDE1347 2.4e-30 137.5 Bacteria racA ko:K11686,ko:K13640,ko:K18997 ko00000,ko03000,ko03036 Bacteria COG0789@1,COG0789@2 NA|NA|NA K bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding MAG.T1.5_03344 330214.NIDE1348 2.6e-184 651.4 Nitrospirae pilM ko:K02662 ko00000,ko02035,ko02044 Bacteria 3J177@40117,COG4972@1,COG4972@2 NA|NA|NA NU Type IV pilus assembly protein PilM; MAG.T1.5_03345 330214.NIDE1349 9.2e-90 336.3 Nitrospirae pilN ko:K02663 ko00000,ko02035,ko02044 Bacteria 3J1EX@40117,COG3166@1,COG3166@2 NA|NA|NA NU Fimbrial assembly protein (PilN) MAG.T1.5_03346 330214.NIDE1350 1.9e-99 368.6 Nitrospirae pilO ko:K02664 ko00000,ko02035,ko02044 Bacteria 3J1BH@40117,COG3167@1,COG3167@2 NA|NA|NA NU Pilus assembly protein, PilO MAG.T1.5_03347 330214.NIDE1351 1.9e-86 325.5 Nitrospirae pilP ko:K02664,ko:K02665 ko00000,ko02035,ko02044 Bacteria 3J1AT@40117,COG3168@1,COG3168@2 NA|NA|NA NU Pilus assembly protein, PilP MAG.T1.5_03348 330214.NIDE1352 4.7e-306 1056.6 Nitrospirae pilQ ko:K02666 ko00000,ko02035,ko02044 3.A.15.2 Bacteria 3J0Q9@40117,COG4796@1,COG4796@2 NA|NA|NA U Secretin and TonB N terminus short domain MAG.T1.5_03349 330214.NIDE1353 9.1e-156 556.6 Nitrospirae aroB 2.7.1.71,4.2.3.4 ko:K01735,ko:K13829 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412,R03083 RC00002,RC00078,RC00847 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0GA@40117,COG0337@1,COG0337@2 NA|NA|NA E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) MAG.T1.5_03350 330214.NIDE1354 2.7e-214 751.1 Nitrospirae 4.2.1.75,4.6.1.1 ko:K01719,ko:K01768,ko:K02584 ko00230,ko00860,ko01100,ko01110,ko01120,ko02020,ko02025,ko04113,ko04213,map00230,map00860,map01100,map01110,map01120,map02020,map02025,map04113,map04213 M00121,M00695 R00089,R00434,R03165 RC00295,RC01861 ko00000,ko00001,ko00002,ko01000,ko03000 Bacteria 3J0XQ@40117,COG2203@1,COG2203@2,COG3605@1,COG3605@2 NA|NA|NA T ANTAR MAG.T1.5_03353 330214.NIDE1358 3e-280 970.7 Nitrospirae nadE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5,6.3.5.1 ko:K01916,ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00189,R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0EB@40117,COG0171@1,COG0171@2,COG0388@1,COG0388@2 NA|NA|NA H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source MAG.T1.5_03354 330214.NIDE1359 1.5e-158 565.5 Bacteria Bacteria 2DZT8@1,32VIB@2 NA|NA|NA MAG.T1.5_03355 330214.NIDE1360 2.2e-214 751.5 Nitrospirae amt ko:K03320 ko00000,ko02000 1.A.11 iHN637.CLJU_c42670,iYO844.BSU36510 Bacteria 3J0IS@40117,COG0004@1,COG0004@2 NA|NA|NA P Ammonium Transporter Family MAG.T1.5_03356 330214.NIDE1361 9.3e-53 212.6 Nitrospirae glnB GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006808,GO:0008144,GO:0008150,GO:0009889,GO:0010565,GO:0017076,GO:0019216,GO:0019217,GO:0019222,GO:0030234,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042304,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045848,GO:0046890,GO:0048518,GO:0050789,GO:0050790,GO:0050794,GO:0062012,GO:0065007,GO:0065009,GO:0080090,GO:0097159,GO:0097367,GO:0098772,GO:1901265,GO:1901363 ko:K02589,ko:K02590,ko:K03320,ko:K04751,ko:K04752 ko02020,map02020 ko00000,ko00001,ko02000 1.A.11 Bacteria 3J0P1@40117,COG0347@1,COG0347@2 NA|NA|NA K Nitrogen regulatory protein P-II MAG.T1.5_03357 330214.NIDE1362 0.0 1587.4 Bacteria glnD 2.7.7.42,2.7.7.59,2.7.7.89 ko:K00982,ko:K00990 ko02020,map02020 ko00000,ko00001,ko01000 Bacteria COG2844@1,COG2844@2 NA|NA|NA O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen MAG.T1.5_03358 330214.NIDE1363 2.5e-277 960.7 Nitrospirae glnA 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 Bacteria 3J0AS@40117,COG0174@1,COG0174@2 NA|NA|NA E Glutamine synthetase, catalytic domain MAG.T1.5_03359 330214.NIDE1364 4.5e-141 507.3 Bacteria nirC GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K02598,ko:K06212,ko:K21993 ko00000,ko02000 1.A.16.1.1,1.A.16.1.3,1.A.16.2,1.A.16.3 iSF_1195.SF3386,iS_1188.S4377 Bacteria COG2116@1,COG2116@2 NA|NA|NA P formate transmembrane transporter activity MAG.T1.5_03360 330214.NIDE1365 1.6e-73 282.0 Bacteria cynS 4.2.1.104 ko:K01725 ko00910,map00910 R03546,R10079 RC00952 ko00000,ko00001,ko01000 Bacteria COG1513@1,COG1513@2 NA|NA|NA P Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide MAG.T1.5_03362 330214.NIDE1367 4.8e-272 943.3 Nitrospirae nirA 1.7.7.1 ko:K00366 ko00910,ko01120,map00910,map01120 M00531 R00790 RC00176 ko00000,ko00001,ko00002,ko01000 Bacteria 3J10S@40117,COG0155@1,COG0155@2 NA|NA|NA C Nitrite and sulphite reductase 4Fe-4S domain MAG.T1.5_03363 330214.NIDE1368 5.9e-119 433.7 Bacteria opuCA 2.7.7.7 ko:K02342,ko:K05847,ko:K07182 ko00230,ko00240,ko01100,ko02010,ko03030,ko03430,ko03440,map00230,map00240,map01100,map02010,map03030,map03430,map03440 M00209,M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko02000,ko03032,ko03400 3.A.1.12 Bacteria COG2905@1,COG2905@2 NA|NA|NA T signal-transduction protein containing cAMP-binding and CBS domains MAG.T1.5_03364 330214.NIDE1370 2.3e-175 621.7 Bacteria Bacteria 2CK9T@1,2Z7W9@2 NA|NA|NA MAG.T1.5_03367 330214.NIDE1376 0.0 1327.0 Bacteria glnE GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0030312,GO:0031323,GO:0033238,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0060359,GO:0062012,GO:0065007,GO:0070566,GO:0071944,GO:0080090,GO:1901698 1.1.1.3,1.4.1.2,2.7.7.42,2.7.7.59,2.7.7.89 ko:K00003,ko:K00982,ko:K00990,ko:K06950,ko:K15371 ko00220,ko00250,ko00260,ko00270,ko00300,ko00430,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,ko02020,map00220,map00250,map00260,map00270,map00300,map00430,map00910,map01100,map01110,map01120,map01130,map01230,map02020 M00017,M00018 R00243,R01773,R01775 RC00006,RC00087,RC02799 ko00000,ko00001,ko00002,ko01000 Bacteria COG1391@1,COG1391@2,COG2844@1,COG2844@2 NA|NA|NA H [glutamate-ammonia-ligase] adenylyltransferase activity MAG.T1.5_03368 330214.NIDE1377 8e-284 982.6 Bacteria glnE GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0030312,GO:0031323,GO:0033238,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0060359,GO:0062012,GO:0065007,GO:0070566,GO:0071944,GO:0080090,GO:1901698 2.7.7.42,2.7.7.89 ko:K00982 ko00000,ko01000 Bacteria COG1391@1,COG1391@2 NA|NA|NA H [glutamate-ammonia-ligase] adenylyltransferase activity MAG.T1.5_03369 330214.NIDE1378 3.7e-296 1023.5 Nitrospirae groL GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0008144,GO:0008150,GO:0009266,GO:0009314,GO:0009405,GO:0009408,GO:0009628,GO:0009966,GO:0009967,GO:0009986,GO:0009987,GO:0010646,GO:0010647,GO:0016032,GO:0016462,GO:0016465,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018995,GO:0019058,GO:0019068,GO:0020003,GO:0022610,GO:0023051,GO:0023056,GO:0030430,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033643,GO:0033644,GO:0033646,GO:0033647,GO:0033648,GO:0033655,GO:0035639,GO:0035821,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043656,GO:0043657,GO:0043900,GO:0043903,GO:0044174,GO:0044175,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044218,GO:0044279,GO:0044403,GO:0044406,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0044650,GO:0044764,GO:0046812,GO:0046872,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0051817,GO:0052047,GO:0052212,GO:0061077,GO:0065007,GO:0065010,GO:0097159,GO:0097367,GO:0101031,GO:1901222,GO:1901224,GO:1901265,GO:1901363,GO:1902531,GO:1902533,GO:1990220,GO:2000535 ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 Bacteria 3J0DA@40117,COG0459@1,COG0459@2 NA|NA|NA O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions MAG.T1.5_03370 330214.NIDE1379 5.2e-47 193.4 Nitrospirae groS GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010033,GO:0016032,GO:0016465,GO:0019058,GO:0019068,GO:0032991,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051704,GO:0061077,GO:0101031,GO:1990220 ko:K04078 ko00000,ko03029,ko03110 Bacteria 3J0RF@40117,COG0234@1,COG0234@2 NA|NA|NA O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter MAG.T1.5_03371 330214.NIDE1380 5e-250 870.2 Bacteria pilL ko:K02487,ko:K20276 ko02020,ko02024,map02020,map02024 M00507 ko00000,ko00001,ko00002,ko02022,ko02035 Bacteria COG3266@1,COG3266@2 NA|NA|NA GM domain, Protein MAG.T1.5_03372 330214.NIDE1381 1e-158 566.2 Bacteria rpoH ko:K03089 ko00000,ko03021 Bacteria COG0568@1,COG0568@2 NA|NA|NA K sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released MAG.T1.5_03373 330214.NIDE1382 5.4e-167 594.0 Nitrospirae nasA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02575 ko00910,map00910 M00615 ko00000,ko00001,ko00002,ko02000 2.A.1.8 iYO844.BSU03330 Bacteria 3J0YQ@40117,COG2223@1,COG2223@2 NA|NA|NA P Major Facilitator Superfamily MAG.T1.5_03374 330214.NIDE1383 5.1e-202 710.3 Nitrospirae ribBA GO:0003674,GO:0003824,GO:0003933,GO:0003935,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0008686,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0016829,GO:0016830,GO:0017144,GO:0018130,GO:0019238,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 3.5.4.25,4.1.99.12 ko:K01497,ko:K02858,ko:K14652 ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS10830,iSB619.SA_RS08945 Bacteria 3J0E0@40117,COG0108@1,COG0108@2,COG0807@1,COG0807@2 NA|NA|NA H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate MAG.T1.5_03375 330214.NIDE1384 1.1e-79 302.8 Nitrospirae ribH GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 iLJ478.TM1825,iSB619.SA_RS08940,iSFV_1184.SFV_0380 Bacteria 3J0QT@40117,COG0054@1,COG0054@2 NA|NA|NA H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin MAG.T1.5_03376 330214.NIDE1385 2.7e-74 284.6 Nitrospirae nusB ko:K03625 ko00000,ko03009,ko03021 Bacteria 3J0RV@40117,COG0781@1,COG0781@2 NA|NA|NA K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons MAG.T1.5_03377 330214.NIDE1386 1.2e-236 825.5 Nitrospirae purB GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 iLJ478.TM1095,iSB619.SA_RS09895 Bacteria 3J0EM@40117,COG0015@1,COG0015@2 NA|NA|NA F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily MAG.T1.5_03378 330214.NIDE1387 2.5e-96 358.6 Bacteria GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016701,GO:0016702,GO:0042597,GO:0044464,GO:0050587,GO:0051213,GO:0055114 1.13.11.49 ko:K09162 ko00000,ko01000 Bacteria COG3253@1,COG3253@2 NA|NA|NA S peroxidase activity MAG.T1.5_03379 330214.NIDE1388 9.9e-121 439.5 Nitrospirae purC GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016874,GO:0016879,GO:0016881,GO:0044424,GO:0044444,GO:0044464 4.1.1.21,4.3.2.2,6.3.2.6 ko:K01587,ko:K01756,ko:K01923 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04209,R04559,R04591 RC00064,RC00162,RC00379,RC00444,RC00445,RC00590 ko00000,ko00001,ko00002,ko01000 iAF1260.b2476,iB21_1397.B21_02330,iBWG_1329.BWG_2240,iE2348C_1286.E2348C_2713,iEC042_1314.EC042_2677,iEC55989_1330.EC55989_2759,iECABU_c1320.ECABU_c27880,iECBD_1354.ECBD_1213,iECB_1328.ECB_02368,iECDH10B_1368.ECDH10B_2642,iECDH1ME8569_1439.ECDH1ME8569_2402,iECDH1ME8569_1439.EcDH1_1193,iECD_1391.ECD_02368,iECED1_1282.ECED1_2911,iECH74115_1262.ECH74115_3698,iECIAI1_1343.ECIAI1_2527,iECNA114_1301.ECNA114_2561,iECO103_1326.ECO103_2988,iECO111_1330.ECO111_3199,iECO26_1355.ECO26_3522,iECOK1_1307.ECOK1_2784,iECP_1309.ECP_2490,iECS88_1305.ECS88_2658,iECSE_1348.ECSE_2760,iECSF_1327.ECSF_2329,iECSP_1301.ECSP_3415,iECUMN_1333.ECUMN_2789,iECW_1372.ECW_m2698,iECs_1301.ECs3338,iEKO11_1354.EKO11_1259,iETEC_1333.ETEC_2581,iEcDH1_1363.EcDH1_1193,iEcE24377_1341.EcE24377A_2757,iEcHS_1320.EcHS_A2607,iEcSMS35_1347.EcSMS35_2623,iEcolC_1368.EcolC_1200,iG2583_1286.G2583_2999,iJN746.PP_1240,iJO1366.b2476,iJR904.b2476,iLF82_1304.LF82_1775,iNRG857_1313.NRG857_12360,iSFV_1184.SFV_2521,iSF_1195.SF2519,iSFxv_1172.SFxv_2773,iS_1188.S2669,iSbBS512_1146.SbBS512_E2848,iUMNK88_1353.UMNK88_3071,iWFL_1372.ECW_m2698,iY75_1357.Y75_RS12925,iYL1228.KPN_02810,iZ_1308.Z3735 Bacteria 3J0U6@40117,COG0152@1,COG0152@2 NA|NA|NA F SAICAR synthetase MAG.T1.5_03381 330214.NIDE1390 1.2e-30 138.7 Bacteria purS 6.3.2.6,6.3.5.3 ko:K01923,ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463,R04591 RC00010,RC00064,RC00162,RC01160 ko00000,ko00001,ko00002,ko01000 iYO844.BSU06460 Bacteria COG1828@1,COG1828@2 NA|NA|NA F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL MAG.T1.5_03382 330214.NIDE1391 2e-121 441.8 Nitrospirae purQ GO:0003674,GO:0003824,GO:0004642,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 Bacteria 3J10Q@40117,COG0047@1,COG0047@2 NA|NA|NA F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL MAG.T1.5_03383 330214.NIDE1392 0.0 1356.7 Nitrospirae purL GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0TJ@40117,COG0046@1,COG0046@2 NA|NA|NA F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL MAG.T1.5_03384 330214.NIDE1393 2.1e-258 897.9 Nitrospirae purF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009507,GO:0009536,GO:0040007,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 iSB619.SA_RS05225 Bacteria 3J0C5@40117,COG0034@1,COG0034@2 NA|NA|NA F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine MAG.T1.5_03385 330214.NIDE1394 5.3e-45 187.2 Bacteria 2.3.2.13 ko:K22452 ko00000,ko01000 Bacteria COG1305@1,COG1305@2 NA|NA|NA E Transglutaminase-like superfamily MAG.T1.5_03386 671143.DAMO_0901 2e-09 68.6 unclassified Bacteria Bacteria 2AAGA@1,2NRQ3@2323,30ZT8@2 NA|NA|NA S Coenzyme PQQ synthesis protein D (PqqD) MAG.T1.5_03389 330214.NIDE1396 3.6e-135 488.0 Bacteria Bacteria COG1493@1,COG1493@2 NA|NA|NA T Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion MAG.T1.5_03390 330214.NIDE1397 6.1e-177 627.1 Bacteria Bacteria COG1216@1,COG1216@2 NA|NA|NA V Glycosyl transferase, family 2 MAG.T1.5_03391 330214.NIDE1399 1.7e-80 305.4 Bacteria Bacteria COG1225@1,COG1225@2 NA|NA|NA O peroxiredoxin activity MAG.T1.5_03393 330214.NIDE1401 4.6e-87 327.4 Bacteria Bacteria COG0491@1,COG0491@2 NA|NA|NA GM Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid MAG.T1.5_03399 330214.NIDE1407 1.4e-227 795.4 Bacteria ko:K02453,ko:K02660 ko02020,ko02025,ko03070,ko05111,map02020,map02025,map03070,map05111 M00331 ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15 Bacteria COG3063@1,COG3063@2 NA|NA|NA NU photosynthesis MAG.T1.5_03400 330214.NIDE1408 0.0 1283.1 Nitrospirae recG GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 ko:K03655 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 3J0E8@40117,COG1200@1,COG1200@2 NA|NA|NA L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) MAG.T1.5_03402 330214.NIDE1410 3.1e-117 428.3 Nitrospirae aroB 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 R03409 RC00002 ko00000,ko00001,ko01000 Bacteria 3J0K5@40117,COG0248@1,COG0248@2 NA|NA|NA FP Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_03403 330214.NIDE1411 5.2e-281 973.0 Bacteria Bacteria COG0500@1,COG2226@2 NA|NA|NA Q methyltransferase MAG.T1.5_03404 330214.NIDE1412 1.7e-47 195.3 Bacteria 1.7.2.1 ko:K00368 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 Bacteria COG3794@1,COG3794@2 NA|NA|NA C PFAM blue (type 1) copper domain protein MAG.T1.5_03407 330214.NIDE1415 1.2e-84 319.3 Bacteria Bacteria COG1750@1,COG1750@2 NA|NA|NA MAG.T1.5_03408 330214.NIDE1416 6e-48 198.4 Bacteria Bacteria COG1357@1,COG1357@2 NA|NA|NA S protein homooligomerization MAG.T1.5_03409 330214.NIDE1417 2e-127 461.8 Nitrospirae scpA ko:K05896 ko00000,ko03036 Bacteria 3J13J@40117,COG1354@1,COG1354@2 NA|NA|NA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves MAG.T1.5_03410 330214.NIDE1418 7.3e-100 370.5 Nitrospirae scpB GO:0003674,GO:0005488,GO:0005515,GO:0042802 ko:K06024 ko00000,ko03036 Bacteria 3J15Z@40117,COG1386@1,COG1386@2 NA|NA|NA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves MAG.T1.5_03412 330214.NIDE1420 0.0 1302.3 Bacteria Bacteria COG3391@1,COG3391@2 NA|NA|NA CO amine dehydrogenase activity MAG.T1.5_03413 330214.NIDE1421 2e-264 917.9 Nitrospirae guaB GO:0003674,GO:0003824,GO:0003938,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 iAPECO1_1312.APECO1_4018,iECABU_c1320.ECABU_c28100,iECP_1309.ECP_2510,iECSF_1327.ECSF_2349,iUTI89_1310.UTI89_C2826,ic_1306.c3027 Bacteria 3J0A1@40117,COG0516@1,COG0516@2,COG0517@1,COG0517@2 NA|NA|NA F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth MAG.T1.5_03414 330214.NIDE1422 1.6e-285 988.0 Nitrospirae guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.3.1.128,6.3.5.2 ko:K01951,ko:K03790 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002,ko03009 iJN746.PP_1032,iLJ478.TM1820,iSF_1195.SF2553,iSFxv_1172.SFxv_2808,iS_1188.S2725,iYL1228.KPN_02833 Bacteria 3J0A2@40117,COG0518@1,COG0518@2,COG0519@1,COG0519@2 NA|NA|NA F Catalyzes the synthesis of GMP from XMP MAG.T1.5_03415 330214.NIDE1423 4.6e-137 494.6 Nitrospirae rsuA GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.19,5.4.99.20,5.4.99.22 ko:K06178,ko:K06181,ko:K06183,ko:K07058 ko00000,ko01000,ko03009 Bacteria 3J0RN@40117,COG1187@1,COG1187@2 NA|NA|NA J Belongs to the pseudouridine synthase RsuA family MAG.T1.5_03416 330214.NIDE1425 0.0 1125.2 Nitrospirae aspS GO:0003674,GO:0003824,GO:0004812,GO:0004815,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006422,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 iJN678.aspS,iSFV_1184.SFV_1868 Bacteria 3J0FR@40117,COG0173@1,COG0173@2 NA|NA|NA J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) MAG.T1.5_03417 330214.NIDE1426 4.1e-188 664.1 Nitrospirae aroC GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 iE2348C_1286.E2348C_2469,iEC55989_1330.EC55989_2573,iECO103_1326.ECO103_2794,iECO111_1330.ECO111_3077,iECO26_1355.ECO26_3317,iECSE_1348.ECSE_2638,iECW_1372.ECW_m2518,iEKO11_1354.EKO11_1436,iIT341.HP0663,iSSON_1240.SSON_2387,iUMNK88_1353.UMNK88_2882,iWFL_1372.ECW_m2518 Bacteria 3J0KQ@40117,COG0082@1,COG0082@2 NA|NA|NA E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system MAG.T1.5_03418 330214.NIDE1428 2.7e-114 419.1 Bacteria modF GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 3.6.3.21,3.6.3.34 ko:K02013,ko:K02028,ko:K05776 ko02010,map02010 M00189,M00236,M00240 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14,3.A.1.3 Bacteria COG1119@1,COG1119@2 NA|NA|NA P ATPase activity MAG.T1.5_03419 330214.NIDE1429 4e-163 580.9 Bacteria 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 Bacteria COG0265@1,COG0265@2 NA|NA|NA O serine-type endopeptidase activity MAG.T1.5_03420 330214.NIDE1430 2.6e-67 261.9 Nitrospirae slp GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0016020,GO:0019867,GO:0042802 ko:K07285 ko00000 Bacteria 3J1BB@40117,COG3065@1,COG3065@2 NA|NA|NA M Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_03421 330214.NIDE1431 7.5e-139 500.0 Bacteria ypfJ GO:0005575,GO:0005576 ko:K07054 ko00000 Bacteria COG2321@1,COG2321@2 NA|NA|NA S Putative neutral zinc metallopeptidase MAG.T1.5_03424 330214.NIDE1434 2.3e-78 298.5 Nitrospirae rluE GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.20,5.4.99.22 ko:K06178,ko:K06181 ko00000,ko01000,ko03009 Bacteria 3J0RN@40117,COG1187@1,COG1187@2 NA|NA|NA J Belongs to the pseudouridine synthase RsuA family MAG.T1.5_03426 768671.ThimaDRAFT_1795 8.4e-34 150.2 Chromatiales tadA 3.5.4.3,3.5.4.33 ko:K01487,ko:K11991 ko00230,ko01100,map00230,map01100 R01676,R10223 RC00204,RC00477 ko00000,ko00001,ko01000,ko03016 Bacteria 1RHM4@1224,1S4RE@1236,1WY1Y@135613,COG0590@1,COG0590@2 NA|NA|NA FJ CMP dCMP deaminase, zinc-binding MAG.T1.5_03430 330214.NIDE1441 1.2e-171 609.0 Bacteria nia 1.8.3.1 ko:K00387 ko00920,ko01100,ko01120,map00920,map01100,map01120 R00533 RC00168 ko00000,ko00001,ko01000 Bacteria COG2041@1,COG2041@2 NA|NA|NA V Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide MAG.T1.5_03432 330214.NIDE0337 1.3e-179 635.6 Bacteria nicK ko:K07467 ko00000 Bacteria COG2946@1,COG2946@2 NA|NA|NA L Replication initiation factor MAG.T1.5_03434 330214.NIDE0295 5.5e-234 816.6 Nitrospirae trmFO GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 2.1.1.74 ko:K04094 ko00000,ko01000,ko03016,ko03036 Bacteria 3J0WT@40117,COG1206@1,COG1206@2 NA|NA|NA J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs MAG.T1.5_03435 330214.NIDE0296 4.1e-130 471.1 Nitrospirae xerC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03733,ko:K04763 ko00000,ko03036 Bacteria 3J0PS@40117,COG4974@1,COG4974@2 NA|NA|NA L Phage integrase, N-terminal SAM-like domain MAG.T1.5_03436 330214.NIDE0297 2.7e-86 324.7 Nitrospirae hslV GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016787,GO:0017076,GO:0019538,GO:0019904,GO:0022607,GO:0030163,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0051603,GO:0065003,GO:0070003,GO:0070011,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 3.4.25.2 ko:K01419 ko00000,ko01000,ko01002 Bacteria 3J10R@40117,COG5405@1,COG5405@2 NA|NA|NA O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery MAG.T1.5_03437 330214.NIDE0298 1.3e-233 815.5 Nitrospirae hslU GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019904,GO:0022607,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043335,GO:0043933,GO:0044085,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1904949,GO:1905368,GO:1905369 ko:K03667 ko00000,ko03110 Bacteria 3J0XE@40117,COG1220@1,COG1220@2 NA|NA|NA O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis MAG.T1.5_03438 330214.NIDE0299 1.1e-156 559.3 Nitrospirae argB GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0030312,GO:0031406,GO:0034618,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS10565,iJN678.argB,iLJ478.TM1784 Bacteria 3J0H3@40117,COG0548@1,COG0548@2 NA|NA|NA E Belongs to the acetylglutamate kinase family. ArgB subfamily MAG.T1.5_03440 330214.NIDE0301 1.8e-82 312.0 Nitrospirae yrdA Bacteria 3J121@40117,COG0663@1,COG0663@2 NA|NA|NA S Bacterial transferase hexapeptide (six repeats) MAG.T1.5_03441 330214.NIDE0302 3.6e-250 870.5 Nitrospirae rimO GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016782,GO:0018193,GO:0018197,GO:0018198,GO:0018339,GO:0019538,GO:0035596,GO:0035599,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901564 2.8.4.4 ko:K14441 R10652 RC00003,RC03217 ko00000,ko01000,ko03009 Bacteria 3J0CD@40117,COG0621@1,COG0621@2 NA|NA|NA J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 MAG.T1.5_03442 330214.NIDE0303 1e-244 852.4 Nitrospirae htrA GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 Bacteria 3J0X9@40117,COG0265@1,COG0265@2 NA|NA|NA M Evidence 2a Function of homologous gene experimentally demonstrated in an other organism MAG.T1.5_03443 330214.NIDE0304 8.5e-249 865.9 Nitrospirae cusS 2.7.13.3 ko:K02484,ko:K07644,ko:K07653 ko02020,map02020 M00452,M00460,M00745 ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022 Bacteria 3J11K@40117,COG5000@1,COG5000@2,COG5002@1,COG5002@2 NA|NA|NA T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain MAG.T1.5_03444 1125863.JAFN01000001_gene724 4.1e-76 291.2 Deltaproteobacteria Bacteria 1MU67@1224,2WJUU@28221,42N90@68525,COG0745@1,COG0745@2 NA|NA|NA K PFAM response regulator receiver MAG.T1.5_03445 330214.NIDE0306 1e-159 569.7 Nitrospirae Bacteria 3J19Q@40117,COG4783@1,COG4783@2 NA|NA|NA S Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_03446 330214.NIDE0307 1.8e-157 562.4 Bacteria yjgN GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria COG4269@1,COG4269@2 NA|NA|NA T membrane MAG.T1.5_03447 330214.NIDE0308 1.9e-69 270.0 Bacteria GO:0000122,GO:0000139,GO:0000976,GO:0000977,GO:0000978,GO:0000987,GO:0000988,GO:0000989,GO:0001012,GO:0001067,GO:0001076,GO:0001190,GO:0001568,GO:0001570,GO:0001666,GO:0001837,GO:0001932,GO:0001934,GO:0001944,GO:0001947,GO:0002009,GO:0002011,GO:0002193,GO:0002376,GO:0002682,GO:0002683,GO:0003007,GO:0003143,GO:0003151,GO:0003157,GO:0003158,GO:0003160,GO:0003169,GO:0003170,GO:0003171,GO:0003174,GO:0003176,GO:0003177,GO:0003179,GO:0003180,GO:0003181,GO:0003183,GO:0003184,GO:0003188,GO:0003190,GO:0003192,GO:0003197,GO:0003198,GO:0003203,GO:0003205,GO:0003206,GO:0003207,GO:0003208,GO:0003209,GO:0003213,GO:0003214,GO:0003222,GO:0003229,GO:0003230,GO:0003231,GO:0003241,GO:0003250,GO:0003252,GO:0003256,GO:0003272,GO:0003273,GO:0003279,GO:0003281,GO:0003330,GO:0003332,GO:0003344,GO:0003348,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0004857,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0005886,GO:0005912,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006357,GO:0006366,GO:0006367,GO:0006725,GO:0006807,GO:0006928,GO:0006950,GO:0006955,GO:0006996,GO:0007049,GO:0007050,GO:0007154,GO:0007162,GO:0007165,GO:0007166,GO:0007219,GO:0007221,GO:0007275,GO:0007368,GO:0007389,GO:0007399,GO:0007507,GO:0007517,GO:0008150,GO:0008152,GO:0008284,GO:0008285,GO:0008593,GO:0009058,GO:0009059,GO:0009628,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009799,GO:0009855,GO:0009887,GO:0009888,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009966,GO:0009967,GO:0009968,GO:0009987,GO:0010002,GO:0010033,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010562,GO:0010594,GO:0010596,GO:0010604,GO:0010605,GO:0010611,GO:0010614,GO:0010628,GO:0010629,GO:0010632,GO:0010633,GO:0010646,GO:0010647,GO:0010648,GO:0010717,GO:0010718,GO:0010720,GO:0010721,GO:0010810,GO:0010812,GO:0010830,GO:0010832,GO:0010941,GO:0010942,GO:0012505,GO:0014013,GO:0014014,GO:0014015,GO:0014031,GO:0014706,GO:0014741,GO:0014743,GO:0016020,GO:0016043,GO:0016070,GO:0016202,GO:0016324,GO:0016477,GO:0016525,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019827,GO:0019899,GO:0022008,GO:0022402,GO:0022603,GO:0022607,GO:0023051,GO:0023052,GO:0023056,GO:0023057,GO:0030030,GO:0030031,GO:0030054,GO:0030154,GO:0030155,GO:0030234,GO:0030278,GO:0030279,GO:0030334,GO:0030335,GO:0030336,GO:0030510,GO:0030513,GO:0030514,GO:0030855,GO:0031090,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031399,GO:0031401,GO:0031974,GO:0031981,GO:0031984,GO:0032101,GO:0032102,GO:0032268,GO:0032270,GO:0032354,GO:0032501,GO:0032502,GO:0032774,GO:0032870,GO:0032879,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0034698,GO:0035050,GO:0035051,GO:0035148,GO:0035239,GO:0035265,GO:0035295,GO:0035886,GO:0035924,GO:0036003,GO:0036293,GO:0036294,GO:0040007,GO:0040008,GO:0040009,GO:0040011,GO:0040012,GO:0040013,GO:0040017,GO:0042127,GO:0042175,GO:0042221,GO:0042325,GO:0042327,GO:0042692,GO:0042981,GO:0043065,GO:0043066,GO:0043067,GO:0043068,GO:0043069,GO:0043086,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043235,GO:0043408,GO:0043410,GO:0043502,GO:0043535,GO:0043537,GO:0043565,GO:0043618,GO:0043620,GO:0044057,GO:0044085,GO:0044087,GO:0044092,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044431,GO:0044432,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0044782,GO:0045177,GO:0045445,GO:0045446,GO:0045595,GO:0045596,GO:0045597,GO:0045661,GO:0045662,GO:0045667,GO:0045668,GO:0045685,GO:0045686,GO:0045687,GO:0045747,GO:0045765,GO:0045786,GO:0045844,GO:0045892,GO:0045893,GO:0045926,GO:0045927,GO:0045934,GO:0045935,GO:0045937,GO:0045944,GO:0045967,GO:0046425,GO:0046427,GO:0046483,GO:0046578,GO:0046579,GO:0046620,GO:0046622,GO:0048468,GO:0048513,GO:0048514,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048562,GO:0048568,GO:0048583,GO:0048584,GO:0048585,GO:0048589,GO:0048598,GO:0048634,GO:0048636,GO:0048638,GO:0048639,GO:0048644,GO:0048646,GO:0048699,GO:0048710,GO:0048711,GO:0048713,GO:0048715,GO:0048729,GO:0048731,GO:0048738,GO:0048762,GO:0048844,GO:0048845,GO:0048856,GO:0048863,GO:0048869,GO:0048870,GO:0050767,GO:0050768,GO:0050769,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0050920,GO:0050922,GO:0051046,GO:0051048,GO:0051049,GO:0051051,GO:0051056,GO:0051057,GO:0051093,GO:0051094,GO:0051128,GO:0051129,GO:0051145,GO:0051147,GO:0051148,GO:0051153,GO:0051154,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051179,GO:0051239,GO:0051240,GO:0051241,GO:0051246,GO:0051247,GO:0051252,GO:0051253,GO:0051254,GO:0051270,GO:0051271,GO:0051272,GO:0051674,GO:0051716,GO:0051726,GO:0051960,GO:0051961,GO:0051962,GO:0055001,GO:0055006,GO:0055008,GO:0055010,GO:0055021,GO:0055023,GO:0055024,GO:0055025,GO:0060039,GO:0060043,GO:0060045,GO:0060251,GO:0060253,GO:0060255,GO:0060271,GO:0060284,GO:0060317,GO:0060379,GO:0060411,GO:0060412,GO:0060415,GO:0060419,GO:0060420,GO:0060421,GO:0060429,GO:0060485,GO:0060537,GO:0060548,GO:0060560,GO:0060562,GO:0060837,GO:0060840,GO:0060841,GO:0060842,GO:0060843,GO:0060947,GO:0060948,GO:0060956,GO:0060973,GO:0060976,GO:0060977,GO:0060979,GO:0060982,GO:0061061,GO:0061311,GO:0061314,GO:0061371,GO:0061383,GO:0061384,GO:0061418,GO:0061419,GO:0065007,GO:0065009,GO:0070013,GO:0070161,GO:0070167,GO:0070168,GO:0070372,GO:0070374,GO:0070482,GO:0070848,GO:0070887,GO:0070925,GO:0071310,GO:0071363,GO:0071371,GO:0071372,GO:0071453,GO:0071456,GO:0071495,GO:0071704,GO:0071840,GO:0071944,GO:0072132,GO:0072358,GO:0072359,GO:0080090,GO:0090049,GO:0090051,GO:0090092,GO:0090100,GO:0090101,GO:0090257,GO:0090287,GO:0090288,GO:0090304,GO:0097084,GO:0097150,GO:0097159,GO:0097659,GO:0098588,GO:0098590,GO:0098727,GO:0098772,GO:0098791,GO:0098827,GO:0120031,GO:0120036,GO:0140110,GO:1901201,GO:1901213,GO:1901342,GO:1901343,GO:1901360,GO:1901362,GO:1901363,GO:1901522,GO:1901532,GO:1901533,GO:1901576,GO:1901861,GO:1901863,GO:1902337,GO:1902339,GO:1902531,GO:1902533,GO:1902679,GO:1902680,GO:1903053,GO:1903054,GO:1903506,GO:1903507,GO:1903508,GO:1903530,GO:1903531,GO:1903670,GO:1903671,GO:1903706,GO:1903707,GO:1904747,GO:1904748,GO:1904892,GO:1904894,GO:1905314,GO:1905456,GO:1905457,GO:1990837,GO:2000026,GO:2000027,GO:2000112,GO:2000113,GO:2000136,GO:2000137,GO:2000145,GO:2000146,GO:2000147,GO:2000181,GO:2000209,GO:2000736,GO:2000737,GO:2000811,GO:2000826,GO:2000973,GO:2000974,GO:2001026,GO:2001027,GO:2001141 ko:K06867,ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 Bacteria COG0457@1,COG0457@2,COG0666@1,COG0666@2 NA|NA|NA G response to abiotic stimulus MAG.T1.5_03448 330214.NIDE0310 9.2e-287 992.3 Nitrospirae frdA GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363 1.3.5.1,1.3.5.4 ko:K00239,ko:K00244 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134 M00009,M00011,M00149,M00150,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 iECIAI39_1322.ECIAI39_4621,iEcSMS35_1347.EcSMS35_4625,iNJ661.Rv1552,iPC815.YPO0360 Bacteria 3J0ZM@40117,COG1053@1,COG1053@2 NA|NA|NA C Fumarate reductase flavoprotein C-term MAG.T1.5_03449 330214.NIDE0312 0.0 1760.0 Nitrospirae gcvP GO:0003674,GO:0003824,GO:0004375,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016638,GO:0016642,GO:0030312,GO:0040007,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944 1.4.4.2 ko:K00281,ko:K00282 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 iECIAI39_1322.ECIAI39_3318 Bacteria 3J0XT@40117,COG0403@1,COG0403@2,COG1003@1,COG1003@2 NA|NA|NA E Glycine cleavage system P-protein MAG.T1.5_03451 330214.NIDE0314 3.3e-146 524.6 Bacteria iunH 3.2.2.1 ko:K01239,ko:K01250 ko00230,ko00760,ko01100,map00230,map00760,map01100 R01245,R01273,R01677,R01770,R02143 RC00033,RC00063,RC00122,RC00318,RC00485 ko00000,ko00001,ko01000 Bacteria COG1957@1,COG1957@2 NA|NA|NA F ribosylpyrimidine nucleosidase activity MAG.T1.5_03452 330214.NIDE0315 4.1e-95 354.8 Bacteria rbsK GO:0003674,GO:0003824,GO:0004747,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019303,GO:0019321,GO:0019323,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046835,GO:0071704,GO:1901575 2.7.1.15,2.7.1.4 ko:K00847,ko:K00852 ko00030,ko00051,ko00500,ko00520,ko01100,map00030,map00051,map00500,map00520,map01100 R00760,R00867,R01051,R02750,R03920 RC00002,RC00017 ko00000,ko00001,ko01000 iE2348C_1286.E2348C_4062,iEcDH1_1363.EcDH1_4215 Bacteria COG0524@1,COG0524@2 NA|NA|NA G Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway MAG.T1.5_03454 1037409.BJ6T_83010 1.2e-111 409.5 Proteobacteria Bacteria 1NCPP@1224,COG3293@1,COG3293@2 NA|NA|NA L Transposase proposed to express due to -1 translational frameshift at the sequence 5'-AAAAAC-3' MAG.T1.5_03455 330214.NIDE0804 1.4e-103 382.5 Bacteria barA GO:0000155,GO:0000160,GO:0000302,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009636,GO:0009927,GO:0009987,GO:0010033,GO:0010035,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042221,GO:0042493,GO:0042542,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046677,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0070887,GO:0071310,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901700 2.7.13.3 ko:K03407,ko:K07678,ko:K14978 ko02020,ko02025,ko02026,ko02030,ko05111,map02020,map02025,map02026,map02030,map05111 M00475,M00506,M00663 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 Bacteria COG0642@1,COG2205@2,COG3437@1,COG3437@2 NA|NA|NA T PhoQ Sensor MAG.T1.5_03456 330214.NIDE0805 0.0 1765.7 Nitrospirae 2.7.13.3 ko:K20974 ko02020,ko02025,map02020,map02025 M00820 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 3J0ZF@40117,COG0784@1,COG0784@2,COG2198@1,COG2198@2,COG2203@1,COG2203@2,COG5002@1,COG5002@2 NA|NA|NA T Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_03457 330214.NIDE0806 1.5e-166 592.4 Bacteria Bacteria COG3287@1,COG3287@2 NA|NA|NA M FIST C domain MAG.T1.5_03459 330214.NIDE0808 9.1e-127 459.5 Bacteria Bacteria 2EGFY@1,33A7X@2 NA|NA|NA MAG.T1.5_03460 330214.NIDE0809 2e-159 568.5 Bacteria Bacteria COG2706@1,COG2706@2 NA|NA|NA G 6-phosphogluconolactonase activity MAG.T1.5_03461 330214.NIDE0810 1.3e-138 499.2 Nitrospirae folD GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1162 Bacteria 3J0FT@40117,COG0190@1,COG0190@2 NA|NA|NA F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate MAG.T1.5_03462 330214.NIDE0811 1.1e-161 575.9 Nitrospirae metF 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0I8@40117,COG0685@1,COG0685@2 NA|NA|NA C Methylenetetrahydrofolate reductase MAG.T1.5_03463 330214.NIDE0812 3.1e-123 448.0 Nitrospirae panB 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0GX@40117,COG0413@1,COG0413@2 NA|NA|NA H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate MAG.T1.5_03464 330214.NIDE0813 8.2e-31 139.8 Bacteria ko:K09763 ko00000 Bacteria COG1547@1,COG1547@2 NA|NA|NA S Domain of unknown function (DUF309) MAG.T1.5_03465 330214.NIDE0814 2.9e-119 434.9 Bacteria apaH GO:0003674,GO:0003824,GO:0004551,GO:0004721,GO:0006139,GO:0006464,GO:0006470,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008138,GO:0008150,GO:0008152,GO:0008796,GO:0008803,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0015949,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0019538,GO:0034641,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0140096,GO:1901360,GO:1901564 3.6.1.41 ko:K01525 ko00230,map00230 R00125 RC00002 ko00000,ko00001,ko01000 iECIAI39_1322.ECIAI39_0052,iEcSMS35_1347.EcSMS35_0053,iJN746.PP_0399,iSDY_1059.SDY_0074 Bacteria COG0639@1,COG0639@2 NA|NA|NA T phosphoprotein phosphatase activity MAG.T1.5_03466 330214.NIDE0815 0.0 1080.5 Nitrospirae Bacteria 3J0ZF@40117,COG0642@1,COG0642@2,COG0745@1,COG0745@2,COG0784@1,COG0784@2,COG2203@1,COG2203@2,COG3829@1,COG3829@2 NA|NA|NA T Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_03467 330214.NIDE0816 0.0 1148.3 Nitrospirae Bacteria 3J0ZF@40117,COG0745@1,COG0745@2,COG0784@1,COG0784@2,COG2198@1,COG2198@2,COG5002@1,COG5002@2 NA|NA|NA T Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_03468 330214.NIDE0817 7.6e-25 119.4 Bacteria Bacteria COG3794@1,COG3794@2 NA|NA|NA C PFAM blue (type 1) copper domain protein MAG.T1.5_03469 330214.NIDE0817 4.8e-39 167.9 Bacteria Bacteria COG3794@1,COG3794@2 NA|NA|NA C PFAM blue (type 1) copper domain protein MAG.T1.5_03470 330214.NIDE0818 7.5e-106 390.2 Bacteria moxG ko:K00406,ko:K16255 ko00190,ko00680,ko01100,ko01120,ko02020,map00190,map00680,map01100,map01120,map02020 M00156 ko00000,ko00001,ko00002 3.D.4.3 Bacteria COG2010@1,COG2010@2 NA|NA|NA C Cytochrome c MAG.T1.5_03471 330214.NIDE0819 7.4e-170 603.6 Bacteria omp12 ko:K12976,ko:K22110 ko00000,ko01000,ko01005,ko02000 1.B.35.1,1.B.35.2 Bacteria COG3637@1,COG3637@2 NA|NA|NA M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety MAG.T1.5_03472 330214.NIDE0820 4.8e-63 247.3 Nitrospirae queF 1.7.1.13 ko:K09457 ko00790,ko01100,map00790,map01100 R07605 RC01875 ko00000,ko00001,ko01000,ko03016 Bacteria 3J0R4@40117,COG0780@1,COG0780@2 NA|NA|NA H Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) MAG.T1.5_03473 330214.NIDE0823 3.3e-153 547.7 Nitrospirae forB 1.2.7.1 ko:K00170 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 3J10F@40117,COG1013@1,COG1013@2 NA|NA|NA C Evidence 2a Function of homologous gene experimentally demonstrated in an other organism MAG.T1.5_03474 330214.NIDE0824 9.4e-119 433.0 Nitrospirae 1.2.7.1 ko:K00172 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 3J0YE@40117,COG1014@1,COG1014@2 NA|NA|NA C Pyruvate ferredoxin/flavodoxin oxidoreductase MAG.T1.5_03475 330214.NIDE0825 7.3e-55 219.5 Nitrospirae porE 1.2.7.1 ko:K00171,ko:K00172,ko:K02573,ko:K13795,ko:K18930 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 3J1A9@40117,COG1144@1,COG1144@2 NA|NA|NA C Oxidoreductase MAG.T1.5_03476 330214.NIDE0826 8e-108 396.4 Nitrospirae porD ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 ko00000,ko00001,ko00002,ko02000 3.A.1.7 Bacteria 3J0YH@40117,COG0226@1,COG0226@2 NA|NA|NA P Evidence 2a Function of homologous gene experimentally demonstrated in an other organism MAG.T1.5_03477 330214.NIDE0827 2.5e-242 844.3 Nitrospirae forA 1.2.7.1 ko:K00169 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 3J105@40117,COG0674@1,COG0674@2 NA|NA|NA C Pyruvate:ferredoxin oxidoreductase core domain II MAG.T1.5_03479 330214.NIDE0829 6.9e-122 444.1 Nitrospirae Bacteria 3J16W@40117,COG5459@1,COG5459@2 NA|NA|NA J Mitochondrial small ribosomal subunit Rsm22 MAG.T1.5_03481 330214.NIDE0832 1.3e-51 209.1 Bacteria Bacteria COG2453@1,COG2453@2 NA|NA|NA T phosphatase MAG.T1.5_03482 330214.NIDE0833 1.4e-113 416.0 Nitrospirae fpg 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 3J17X@40117,COG0266@1,COG0266@2 NA|NA|NA L Formamidopyrimidine-DNA glycosylase H2TH domain MAG.T1.5_03483 330214.NIDE0834 5.2e-207 726.9 Nitrospirae 2.3.3.8,6.2.1.18 ko:K15231,ko:K15232 ko00020,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00720,map01100,map01110,map01120,map01130,map01200 M00173 R00352,R01322 RC00004,RC00014,RC00067 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_0305 Bacteria 3J185@40117,COG0045@1,COG0045@2 NA|NA|NA H ATP citrate lyase citrate-binding MAG.T1.5_03484 330214.NIDE0835 0.0 1114.4 Bacteria 2.3.3.8,6.2.1.5 ko:K01902,ko:K15230,ko:K15233 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00352,R00405,R01322,R02404 RC00004,RC00014,RC00067 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_0306 Bacteria COG0074@1,COG0074@2,COG0372@1,COG0372@2 NA|NA|NA C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit MAG.T1.5_03485 330214.NIDE0836 0.0 1388.6 Nitrospirae acnA 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 3J0E6@40117,COG1048@1,COG1048@2 NA|NA|NA C Aconitase C-terminal domain MAG.T1.5_03486 330214.NIDE0837 0.0 1270.8 Bacteria icd 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria COG2838@1,COG2838@2 NA|NA|NA C Isocitrate dehydrogenase MAG.T1.5_03487 330214.NIDE0838 1.3e-133 482.3 Nitrospirae Bacteria 3J11C@40117,COG1152@1,COG1152@2 NA|NA|NA C 4Fe-4S ferredoxin iron-sulfur binding domain protein MAG.T1.5_03488 330214.NIDE0839 2.4e-292 1010.7 Nitrospirae 1.3.5.1,1.3.5.4,1.4.3.16 ko:K00239,ko:K00244,ko:K00278 ko00020,ko00190,ko00250,ko00620,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00250,map00620,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map02020,map05134 M00009,M00011,M00115,M00149,M00150,M00173,M00374,M00376 R00357,R00481,R02164 RC00006,RC00045,RC02566 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0WB@40117,COG0029@1,COG0029@2 NA|NA|NA C FAD binding domain MAG.T1.5_03489 330214.NIDE0840 5.7e-206 723.4 Nitrospirae sucC 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0ZB@40117,COG0045@1,COG0045@2 NA|NA|NA F Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit MAG.T1.5_03490 330214.NIDE0841 2.1e-152 545.0 Nitrospirae sucD 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0WZ@40117,COG0074@1,COG0074@2 NA|NA|NA C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit MAG.T1.5_03491 1123368.AUIS01000019_gene1217 1.3e-63 250.0 Gammaproteobacteria Bacteria 1R5GU@1224,1SIPM@1236,COG2220@1,COG2220@2 NA|NA|NA S Zn-dependent hydrolases of the beta-lactamase fold MAG.T1.5_03492 330214.NIDE0843 2.1e-299 1034.2 Nitrospirae Bacteria 3J18Y@40117,COG1032@1,COG1032@2 NA|NA|NA C B12 binding domain MAG.T1.5_03493 330214.NIDE0845 4.5e-225 786.9 Nitrospirae ahcY GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 Bacteria 3J0AH@40117,COG0499@1,COG0499@2 NA|NA|NA H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine MAG.T1.5_03494 330214.NIDE0846 4.7e-213 746.9 Nitrospirae metK GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0A4@40117,COG0192@1,COG0192@2 NA|NA|NA H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme MAG.T1.5_03495 330214.NIDE0847 3e-265 920.6 Nitrospirae ccs1 ko:K07399 ko00000 Bacteria 3J0N7@40117,COG1333@1,COG1333@2 NA|NA|NA O ResB-like family MAG.T1.5_03496 330214.NIDE0848 3e-170 604.4 Nitrospirae ccsA GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008152,GO:0015886,GO:0016020,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0055114,GO:0071702,GO:0071705,GO:0071944,GO:1901678 Bacteria 3J0NY@40117,COG0755@1,COG0755@2 NA|NA|NA O Cytochrome C assembly protein MAG.T1.5_03497 330214.NIDE0849 1e-100 372.9 Nitrospirae resA Bacteria 3J0SG@40117,COG0526@1,COG0526@2 NA|NA|NA CO Thioredoxin-like MAG.T1.5_03498 330214.NIDE0850 7.5e-79 300.1 Bacteria Bacteria COG0526@1,COG0526@2 NA|NA|NA CO cell redox homeostasis MAG.T1.5_03499 330214.NIDE0851 1e-123 449.5 Nitrospirae ccdA ko:K06196 ko00000,ko02000 5.A.1.2 Bacteria 3J0KU@40117,COG0785@1,COG0785@2 NA|NA|NA O Cytochrome C biogenesis protein transmembrane region MAG.T1.5_03500 330214.NIDE0852 7.5e-169 600.1 Nitrospirae fixC Bacteria 3J0UE@40117,COG0644@1,COG0644@2 NA|NA|NA C oxidoreductase MAG.T1.5_03501 330214.NIDE0853 3.2e-127 461.5 Nitrospirae bamD ko:K05807,ko:K08309 ko00000,ko01000,ko01011,ko02000 1.B.33.1 GH23 Bacteria 3J0UU@40117,COG4105@1,COG4105@2 NA|NA|NA S Tetratricopeptide repeat MAG.T1.5_03502 330214.NIDE0854 1.3e-142 512.7 Nitrospirae fabH 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 3J0FW@40117,COG0332@1,COG0332@2 NA|NA|NA I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids MAG.T1.5_03503 330214.NIDE0855 2.3e-89 335.1 Bacteria MA20_27875 ko:K02039,ko:K07220 ko00000 Bacteria COG1392@1,COG1392@2 NA|NA|NA P Protein of unknown function DUF47 MAG.T1.5_03504 330214.NIDE0856 1.7e-150 538.9 Nitrospirae pit ko:K03306 ko00000 2.A.20 Bacteria 3J1D1@40117,COG0306@1,COG0306@2 NA|NA|NA P Phosphate transporter family MAG.T1.5_03505 330214.NIDE0857 6.7e-294 1016.1 Nitrospirae phoR 2.7.13.3 ko:K02484,ko:K07636,ko:K07768 ko02020,map02020 M00434,M00443 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 3J0I0@40117,COG5002@1,COG5002@2 NA|NA|NA T His Kinase A (phosphoacceptor) domain MAG.T1.5_03506 330214.NIDE0858 1.4e-122 445.7 Nitrospirae Bacteria 3J0JU@40117,COG0745@1,COG0745@2 NA|NA|NA K Transcriptional regulatory protein, C terminal MAG.T1.5_03507 330214.NIDE0859 1.1e-173 615.9 Nitrospirae ispH 1.17.7.4,2.7.4.25 ko:K00945,ko:K02945,ko:K03527 ko00240,ko00900,ko01100,ko01110,ko01130,ko03010,map00240,map00900,map01100,map01110,map01130,map03010 M00052,M00096,M00178 R00158,R00512,R01665,R05884,R08210 RC00002,RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko03011 iIT341.HP0400,iLJ478.TM1444 Bacteria 3J0PP@40117,COG0761@1,COG0761@2 NA|NA|NA IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis MAG.T1.5_03508 330214.NIDE0860 0.0 1862.0 Nitrospirae smc ko:K03529 ko00000,ko03036 Bacteria 3J0W4@40117,COG1196@1,COG1196@2 NA|NA|NA D Required for chromosome condensation and partitioning MAG.T1.5_03509 330214.NIDE0861 0.0 1326.2 Nitrospirae shc 4.2.1.129,5.4.99.17 ko:K06045 ko00909,ko01110,map00909,map01110 R07322,R07323 RC01850,RC01851 ko00000,ko00001,ko01000 Bacteria 3J0ZD@40117,COG1657@1,COG1657@2 NA|NA|NA I Squalene-hopene cyclase C-terminal domain MAG.T1.5_03510 330214.NIDE0862 2.9e-94 351.7 Bacteria MA20_16045 1.17.7.4,3.2.2.9 ko:K01243,ko:K03527 ko00270,ko00900,ko01100,ko01110,ko01130,ko01230,map00270,map00900,map01100,map01110,map01130,map01230 M00034,M00096,M00609 R00194,R01401,R05884,R08210 RC00063,RC00318,RC01137,RC01487 ko00000,ko00001,ko00002,ko01000 Bacteria COG0775@1,COG0775@2 NA|NA|NA F adenosylhomocysteine nucleosidase activity MAG.T1.5_03511 330214.NIDE0863 9.7e-130 469.5 Nitrospirae mlaE GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02066 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 3J0I7@40117,COG0767@1,COG0767@2 NA|NA|NA Q Permease MlaE MAG.T1.5_03512 330214.NIDE0864 6.7e-123 446.8 Nitrospirae metN ko:K02065 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 3J0J2@40117,COG1127@1,COG1127@2 NA|NA|NA Q ABC transporter MAG.T1.5_03513 330214.NIDE0865 4.2e-69 267.3 Nitrospirae ko:K02067 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 3J191@40117,COG1463@1,COG1463@2 NA|NA|NA Q MlaD protein MAG.T1.5_03514 330214.NIDE0866 2.3e-94 351.7 Nitrospirae ko:K07323 ko02010,map02010 M00210 ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 Bacteria 3J13Z@40117,COG2854@1,COG2854@2 NA|NA|NA Q Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_03515 330214.NIDE0867 8.7e-210 736.1 Nitrospirae Bacteria 3J10P@40117,COG4775@1,COG4775@2 NA|NA|NA M Surface antigen MAG.T1.5_03516 330214.NIDE0868 1.4e-157 562.4 Bacteria Bacteria COG2067@1,COG2067@2 NA|NA|NA I long-chain fatty acid transporting porin activity MAG.T1.5_03517 330214.NIDE0869 0.0 1239.2 Nitrospirae dxs GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008614,GO:0008615,GO:0008654,GO:0008661,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009240,GO:0009987,GO:0016740,GO:0016744,GO:0017144,GO:0018130,GO:0019288,GO:0019438,GO:0019637,GO:0019682,GO:0019752,GO:0019842,GO:0030145,GO:0030975,GO:0030976,GO:0032787,GO:0034641,GO:0036094,GO:0040007,GO:0042180,GO:0042181,GO:0042364,GO:0042723,GO:0042724,GO:0042816,GO:0042819,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:1901135,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663,GO:1901681 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 iEcSMS35_1347.EcSMS35_0456,iJN746.PP_0527 Bacteria 3J0WE@40117,COG1154@1,COG1154@2 NA|NA|NA H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) MAG.T1.5_03518 330214.NIDE0870 1.3e-210 738.8 Nitrospirae ispG GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009055,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0022900,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046429,GO:0046490,GO:0046872,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 iAF1260.b2515,iAPECO1_1312.APECO1_4009,iB21_1397.B21_02369,iBWG_1329.BWG_2279,iE2348C_1286.E2348C_2798,iEC55989_1330.EC55989_2800,iECABU_c1320.ECABU_c28200,iECBD_1354.ECBD_1171,iECB_1328.ECB_02407,iECDH10B_1368.ECDH10B_2681,iECDH1ME8569_1439.ECDH1ME8569_2442,iECDH1ME8569_1439.EcDH1_1153,iECD_1391.ECD_02407,iECED1_1282.ECED1_2946,iECH74115_1262.ECH74115_3740,iECIAI39_1322.ECIAI39_2716,iECNA114_1301.ECNA114_2593,iECO103_1326.ECO103_3032,iECO111_1330.ECO111_3239,iECO26_1355.ECO26_3562,iECOK1_1307.ECOK1_2863,iECP_1309.ECP_2520,iECS88_1305.ECS88_2691,iECSE_1348.ECSE_2801,iECSF_1327.ECSF_2359,iECSP_1301.ECSP_3455,iECW_1372.ECW_m2740,iECs_1301.ECs3377,iEKO11_1354.EKO11_1218,iETEC_1333.ETEC_2672,iEcDH1_1363.EcDH1_1153,iEcE24377_1341.EcE24377A_2799,iEcolC_1368.EcolC_1162,iHN637.CLJU_RS06430,iIT341.HP0625,iJN678.gcpE,iJO1366.b2515,iJR904.b2515,iLF82_1304.LF82_1130,iNRG857_1313.NRG857_12515,iUMN146_1321.UM146_04130,iUMNK88_1353.UMNK88_3165,iUTI89_1310.UTI89_C2836,iWFL_1372.ECW_m2740,iY75_1357.Y75_RS13130,iYL1228.KPN_02845,iZ_1308.Z3778,ic_1306.c3037 Bacteria 3J0EA@40117,COG0821@1,COG0821@2 NA|NA|NA I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate MAG.T1.5_03521 710686.Mycsm_01181 2.1e-27 128.6 Mycobacteriaceae Bacteria 23DVG@1762,2FBTW@1,2H64G@201174,321XM@2 NA|NA|NA S Antitoxin Phd_YefM, type II toxin-antitoxin system MAG.T1.5_03522 710686.Mycsm_01180 1.1e-73 283.1 Mycobacteriaceae Bacteria 23CAG@1762,2GX9Z@201174,COG4185@1,COG4185@2 NA|NA|NA S Zeta toxin MAG.T1.5_03523 1009370.ALO_09639 5.3e-37 160.2 Negativicutes GO:0005575,GO:0005576 ko:K09771 ko00000,ko02000 2.A.7.26 Bacteria 1V6YJ@1239,4H5CN@909932,COG1742@1,COG1742@2 NA|NA|NA S UPF0060 membrane protein MAG.T1.5_03524 330214.NIDE2781 0.0 1204.1 Bacteria Bacteria COG1032@1,COG1032@2 NA|NA|NA C radical SAM domain protein MAG.T1.5_03525 330214.NIDE2780 0.0 1260.4 Bacteria Bacteria COG1032@1,COG1032@2 NA|NA|NA C radical SAM domain protein MAG.T1.5_03527 330214.NIDE2778 3.3e-231 807.4 Bacteria Bacteria COG0535@1,COG0535@2 NA|NA|NA I radical SAM domain protein MAG.T1.5_03528 330214.NIDE2777 2.7e-158 564.7 Bacteria yddE 5.3.3.17 ko:K06998 ko00405,ko01130,ko02024,map00405,map01130,map02024 M00835 ko00000,ko00001,ko00002,ko01000 Bacteria COG0384@1,COG0384@2 NA|NA|NA S isomerase activity MAG.T1.5_03529 330214.NIDE2776 1.2e-183 649.0 Nitrospirae 1.1.1.1 ko:K00001 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 Bacteria 3J13T@40117,COG0604@1,COG0604@2 NA|NA|NA C Zinc-binding dehydrogenase MAG.T1.5_03530 330214.NIDE2775 2.1e-65 255.0 Nitrospirae ko:K10716 ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 Bacteria 3J1AQ@40117,COG2905@1,COG2905@2 NA|NA|NA T Domain in cystathionine beta-synthase and other proteins. MAG.T1.5_03531 330214.NIDE2773 5.1e-70 270.4 Bacteria moaB 2.7.7.75 ko:K03638 ko00790,ko01100,map00790,map01100 R09726 RC00002 ko00000,ko00001,ko01000 Bacteria COG0521@1,COG0521@2 NA|NA|NA H Mo-molybdopterin cofactor metabolic process MAG.T1.5_03532 330214.NIDE2772 3e-56 224.2 Bacteria fdx4 Bacteria COG3411@1,COG3411@2 NA|NA|NA C Ferredoxin MAG.T1.5_03533 330214.NIDE2770 5.3e-81 307.0 Bacteria Bacteria COG2105@1,COG2105@2 NA|NA|NA F PFAM AIG2 family protein MAG.T1.5_03535 330214.NIDE2767 1.3e-46 192.2 Nitrospirae 1.7.1.15 ko:K00363,ko:K05710 ko00360,ko00910,ko01120,ko01220,map00360,map00910,map01120,map01220 M00530,M00545 R00787,R06782,R06783 RC00098,RC00176 br01602,ko00000,ko00001,ko00002,ko01000 Bacteria 3J1E7@40117,COG2146@1,COG2146@2 NA|NA|NA P Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_03536 330214.NIDE2766 1.8e-101 375.2 Nitrospirae MA20_20605 Bacteria 3J0VM@40117,COG1403@1,COG1403@2 NA|NA|NA L HNH nucleases MAG.T1.5_03537 330214.NIDE2765 4.3e-69 267.3 Bacteria cycH 3.4.21.105 ko:K02200,ko:K04018,ko:K19225,ko:K20543,ko:K21007 ko02025,map02025 ko00000,ko00001,ko01000,ko01002,ko02000 1.B.55.3 Bacteria COG4235@1,COG4235@2 NA|NA|NA O cytochrome complex assembly MAG.T1.5_03538 330214.NIDE2764 8.6e-103 379.8 Bacteria cysG GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009628,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.76,2.1.1.107,4.99.1.4 ko:K02302,ko:K02304 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03194,R03947 RC00003,RC00871,RC01012,RC01034 ko00000,ko00001,ko00002,ko01000 iECIAI1_1343.ECIAI1_3507,iECSE_1348.ECSE_3630,iEcE24377_1341.EcE24377A_3838,iJN746.PP_3999,iPC815.YPO0158 Bacteria COG1648@1,COG1648@2 NA|NA|NA H precorrin-2 dehydrogenase activity MAG.T1.5_03539 330214.NIDE2763 7e-47 193.0 Nitrospirae GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 Bacteria 3J0QD@40117,COG0011@1,COG0011@2 NA|NA|NA S Thiamine-binding protein MAG.T1.5_03540 861299.J421_3028 2.2e-18 100.5 Gemmatimonadetes Bacteria 1ZT4C@142182,28M10@1,301VW@2 NA|NA|NA S Domain of unknown function (DUF4403) MAG.T1.5_03541 330214.NIDE2761 1.4e-156 559.3 Nitrospirae alr 5.1.1.1,6.3.2.10 ko:K01775,ko:K01929 ko00300,ko00473,ko00550,ko01100,ko01502,map00300,map00473,map00550,map01100,map01502 R00401,R04573,R04617 RC00064,RC00141,RC00285 ko00000,ko00001,ko01000,ko01011 Bacteria 3J0JH@40117,COG0787@1,COG0787@2 NA|NA|NA E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids MAG.T1.5_03542 330214.NIDE2760 4.2e-90 337.4 Nitrospirae frr GO:0002181,GO:0002184,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0030312,GO:0032984,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02838 ko00000,ko03012 Bacteria 3J0KJ@40117,COG0233@1,COG0233@2 NA|NA|NA J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another MAG.T1.5_03543 330214.NIDE2759 1.5e-124 452.2 Nitrospirae pyrH GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006225,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009163,GO:0009165,GO:0009185,GO:0009188,GO:0009193,GO:0009194,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0033862,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042455,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046048,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046872,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 R00158 RC00002 ko00000,ko00001,ko01000 iSB619.SA_RS06240 Bacteria 3J0BE@40117,COG0528@1,COG0528@2 NA|NA|NA F Catalyzes the reversible phosphorylation of UMP to UDP MAG.T1.5_03544 330214.NIDE2758 4.7e-100 370.5 Nitrospirae tsf GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0030312,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02357 ko00000,ko03012,ko03029 Bacteria 3J0I2@40117,COG0264@1,COG0264@2 NA|NA|NA J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome MAG.T1.5_03545 330214.NIDE2757 7e-136 490.0 Nitrospirae rpsB GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02967 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0G9@40117,COG0052@1,COG0052@2 NA|NA|NA J Belongs to the universal ribosomal protein uS2 family MAG.T1.5_03546 330214.NIDE2756 5e-189 667.2 Nitrospirae argJ GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35,2.7.2.8 ko:K00620,ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282,R02649 RC00002,RC00004,RC00043,RC00064 ko00000,ko00001,ko00002,ko01000 iLJ478.TM1783 Bacteria 3J0B5@40117,COG1364@1,COG1364@2 NA|NA|NA E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate MAG.T1.5_03547 330214.NIDE2755 5.4e-179 633.6 Nitrospirae argC GO:0000166,GO:0003674,GO:0005488,GO:0008150,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0048037,GO:0050661,GO:0050662,GO:0070401,GO:0097159,GO:1901265,GO:1901363 1.2.1.38 ko:K00145,ko:K05829 ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230 M00028,M00031,M00763,M00845 R03443,R09777,R10931 RC00684 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0H9@40117,COG0002@1,COG0002@2 NA|NA|NA E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde MAG.T1.5_03548 330214.NIDE2754 7e-60 236.5 Nitrospirae rpsI GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02996 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0N4@40117,COG0103@1,COG0103@2 NA|NA|NA J Belongs to the universal ribosomal protein uS9 family MAG.T1.5_03549 330214.NIDE2753 2.1e-68 265.0 Nitrospirae rplM GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0070180,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 ko:K02871 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0NE@40117,COG0102@1,COG0102@2 NA|NA|NA J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly MAG.T1.5_03550 330214.NIDE2752 1.3e-74 285.8 Nitrospirae GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 ko:K03617,ko:K08999 ko00000 Bacteria 3J0RC@40117,COG1259@1,COG1259@2 NA|NA|NA S Bifunctional nuclease MAG.T1.5_03551 330214.NIDE2751 2.4e-75 288.1 Nitrospirae GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 ko:K03617,ko:K08999 ko00000 Bacteria 3J0RC@40117,COG1259@1,COG1259@2 NA|NA|NA S Bifunctional nuclease MAG.T1.5_03552 330214.NIDE2750 4.6e-45 186.8 Nitrospirae yggX GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0033554,GO:0034599,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0070887 Bacteria 3J1CU@40117,COG2924@1,COG2924@2 NA|NA|NA C Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes MAG.T1.5_03555 330214.NIDE2748 4.3e-34 150.6 Nitrospirae tusA 1.8.7.1 ko:K00392 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00859,R03600 RC00065 ko00000,ko00001,ko00002,ko01000 Bacteria 3J1DD@40117,COG0425@1,COG0425@2 NA|NA|NA O Sulfurtransferase TusA MAG.T1.5_03556 330214.NIDE2747 5.5e-69 267.7 Nitrospirae rsmI GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.198 ko:K07056 ko00000,ko01000,ko03009 Bacteria 3J0PU@40117,COG0313@1,COG0313@2 NA|NA|NA H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA MAG.T1.5_03557 330214.NIDE2746 4.5e-138 497.3 Nitrospirae Bacteria 3J14H@40117,COG0755@1,COG0755@2 NA|NA|NA O Cytochrome C assembly protein MAG.T1.5_03558 330214.NIDE2745 1.4e-230 805.4 Nitrospirae hemA GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040 1.2.1.70 ko:K02407,ko:K02492 ko00860,ko01100,ko01110,ko01120,ko02040,map00860,map01100,map01110,map01120,map02040 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000,ko02035 Bacteria 3J0BD@40117,COG0373@1,COG0373@2 NA|NA|NA H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) MAG.T1.5_03559 330214.NIDE2744 6.9e-154 550.1 Nitrospirae hemC GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018065,GO:0018130,GO:0018160,GO:0018193,GO:0018198,GO:0019438,GO:0019538,GO:0033013,GO:0033014,GO:0034641,GO:0036211,GO:0042168,GO:0042440,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107,2.5.1.61,4.2.1.75 ko:K01749,ko:K13542 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084,R03165,R03194 RC00003,RC00871,RC01861,RC02317 ko00000,ko00001,ko00002,ko01000 iEC55989_1330.EC55989_4275,iECH74115_1262.ECH74115_5243,iECIAI1_1343.ECIAI1_3991,iECO103_1326.ECO103_4362,iECO111_1330.ECO111_4628,iECO26_1355.ECO26_4784,iECSE_1348.ECSE_4086,iEKO11_1354.EKO11_4554,iHN637.CLJU_RS15760,iPC815.YPO3849 Bacteria 3J0GC@40117,COG0181@1,COG0181@2 NA|NA|NA H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps MAG.T1.5_03560 330214.NIDE2743 3e-242 844.3 Nitrospirae cobA GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 ko:K01719,ko:K02302,ko:K02303,ko:K13542 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03165,R03194,R03947 RC00003,RC00871,RC01012,RC01034,RC01861 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS15755,iYO844.BSU15610 Bacteria 3J0B6@40117,COG0007@1,COG0007@2,COG1587@1,COG1587@2 NA|NA|NA H Belongs to the precorrin methyltransferase family MAG.T1.5_03561 330214.NIDE2742 8.8e-63 246.1 Bacteria opuCA 2.7.7.7 ko:K02342,ko:K05847,ko:K07182 ko00230,ko00240,ko01100,ko02010,ko03030,ko03430,ko03440,map00230,map00240,map01100,map02010,map03030,map03430,map03440 M00209,M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko02000,ko03032,ko03400 3.A.1.12 Bacteria COG2905@1,COG2905@2 NA|NA|NA T signal-transduction protein containing cAMP-binding and CBS domains MAG.T1.5_03562 330214.NIDE2741 1.8e-168 598.6 Nitrospirae hemB GO:0000287,GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 iECABU_c1320.ECABU_c04500,iEcSMS35_1347.EcSMS35_0398,iJN746.PP_2913,ic_1306.c0477 Bacteria 3J0DV@40117,COG0113@1,COG0113@2 NA|NA|NA H Delta-aminolevulinic acid dehydratase MAG.T1.5_03563 330214.NIDE2740 2.7e-145 521.5 Nitrospirae ribF 2.7.1.26,2.7.7.2 ko:K07011,ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS06310 Bacteria 3J0KY@40117,COG0196@1,COG0196@2 NA|NA|NA H Riboflavin kinase MAG.T1.5_03564 330214.NIDE2739 4.8e-157 561.2 Nitrospirae tilS 2.8.1.15,6.3.4.19 ko:K04075,ko:K14058,ko:K21947 R09597 RC02633,RC02634 ko00000,ko01000,ko03016 Bacteria 3J0SX@40117,COG0037@1,COG0037@2 NA|NA|NA D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine MAG.T1.5_03565 330214.NIDE2738 9.8e-92 342.8 Nitrospirae hpt 2.4.2.8,2.7.4.3 ko:K00760,ko:K00939 ko00230,ko00730,ko00983,ko01100,ko01110,ko01130,map00230,map00730,map00983,map01100,map01110,map01130 M00049 R00127,R00190,R01132,R01229,R01547,R02142,R08237,R08238,R08245,R11319 RC00002,RC00063,RC00122 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 3J0NZ@40117,COG0634@1,COG0634@2 NA|NA|NA F Phosphoribosyl transferase domain MAG.T1.5_03566 330214.NIDE2737 0.0 1169.5 Nitrospirae ftsH GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019222,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 ko:K03798 M00742 ko00000,ko00002,ko01000,ko01002,ko03110 Bacteria 3J0AG@40117,COG0465@1,COG0465@2 NA|NA|NA D Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins MAG.T1.5_03567 330214.NIDE2736 5.1e-113 414.1 Nitrospirae folP GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.15,2.7.6.3 ko:K00796,ko:K13941 ko00790,ko01100,map00790,map01100 M00126,M00840,M00841 R03066,R03067,R03503 RC00002,RC00017,RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0NS@40117,COG0294@1,COG0294@2 NA|NA|NA H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives MAG.T1.5_03568 330214.NIDE2735 1e-243 849.0 Nitrospirae glmM GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006464,GO:0006468,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008966,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019538,GO:0034641,GO:0034654,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046777,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 R02060 RC00408 ko00000,ko00001,ko01000 iAF987.Gmet_1886,iSBO_1134.SBO_3206 Bacteria 3J0E7@40117,COG1109@1,COG1109@2 NA|NA|NA G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate MAG.T1.5_03569 330214.NIDE2734 0.0 1168.7 Nitrospirae ko:K02238 M00429 ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 Bacteria 3J0VB@40117,COG0658@1,COG0658@2,COG2333@1,COG2333@2 NA|NA|NA S Competence protein MAG.T1.5_03570 330214.NIDE2733 1.7e-135 489.2 Bacteria Bacteria COG0438@1,COG0438@2 NA|NA|NA M transferase activity, transferring glycosyl groups MAG.T1.5_03571 330214.NIDE2732 6.4e-172 610.1 Nitrospirae Bacteria 3J09X@40117,COG0399@1,COG0399@2 NA|NA|NA E Belongs to the DegT DnrJ EryC1 family MAG.T1.5_03572 330214.NIDE2731 9.7e-157 559.7 Nitrospirae mtnA GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.23 ko:K08963 ko00270,ko01100,map00270,map01100 M00034 R04420 RC01151 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_0072 Bacteria 3J0G0@40117,COG0182@1,COG0182@2 NA|NA|NA E Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) MAG.T1.5_03573 330214.NIDE2730 1.4e-69 268.9 Nitrospirae ndk GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 Bacteria 3J0PH@40117,COG0105@1,COG0105@2 NA|NA|NA F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate MAG.T1.5_03574 330214.NIDE2729 1.1e-228 799.3 Bacteria 3.2.1.51 ko:K01206,ko:K07114,ko:K07126 ko00511,map00511 ko00000,ko00001,ko01000,ko02000,ko04147 1.A.13.2.2,1.A.13.2.3 GH29 Bacteria COG1729@1,COG1729@2 NA|NA|NA S protein trimerization MAG.T1.5_03575 330214.NIDE2728 1.1e-62 245.7 Nitrospirae gcvH ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 Bacteria 3J0SD@40117,COG0509@1,COG0509@2 NA|NA|NA E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein MAG.T1.5_03576 330214.NIDE2727 1.1e-238 832.4 Nitrospirae lpdA 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 3J0IM@40117,COG1249@1,COG1249@2 NA|NA|NA C Evidence 2a Function of homologous gene experimentally demonstrated in an other organism MAG.T1.5_03577 330214.NIDE2726 5.6e-39 167.5 Bacteria comEA 2.4.1.21 ko:K00703,ko:K02237,ko:K02238 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00429,M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003,ko02044 3.A.11.1,3.A.11.2 GT5 Bacteria COG1555@1,COG1555@2 NA|NA|NA L photosystem II stabilization MAG.T1.5_03578 330214.NIDE2725 2.3e-202 711.4 Nitrospirae tyrS GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006437,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 iJN746.PP_0436,iLJ478.TM0478 Bacteria 3J0FX@40117,COG0162@1,COG0162@2 NA|NA|NA J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) MAG.T1.5_03580 330214.NIDE2724 1.3e-236 825.5 Bacteria ko:K01993,ko:K16922 ko00000,ko01002 Bacteria COG0845@1,COG0845@2,COG2203@1,COG2203@2 NA|NA|NA T Gaf domain MAG.T1.5_03581 330214.NIDE2723 0.0 1261.5 Bacteria yydH ko:K01993,ko:K13408,ko:K16922 ko04626,map04626 M00339 ko00000,ko00001,ko00002,ko01002,ko02000,ko02044 8.A.1 Bacteria COG0845@1,COG0845@2,COG1994@1,COG1994@2 NA|NA|NA S metallopeptidase activity MAG.T1.5_03582 330214.NIDE2722 1.7e-307 1061.2 Nitrospirae secA ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 Bacteria 3J0E5@40117,COG0653@1,COG0653@2 NA|NA|NA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane MAG.T1.5_03583 330214.NIDE2721 4.5e-107 394.0 Bacteria cusB ko:K13888 M00709 ko00000,ko00002,ko02000 8.A.1 Bacteria COG0845@1,COG0845@2 NA|NA|NA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family MAG.T1.5_03584 330214.NIDE2720 0.0 1083.2 Bacteria 3.2.1.202 ko:K21606 ko00000,ko01000 CBM5,GH18 Bacteria COG3866@1,COG3866@2 NA|NA|NA G Pectate lyase MAG.T1.5_03585 330214.NIDE2719 1.5e-120 439.1 Bacteria cusB ko:K13888 M00709 ko00000,ko00002,ko02000 8.A.1 Bacteria COG0845@1,COG0845@2 NA|NA|NA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family MAG.T1.5_03586 330214.NIDE2718 4.2e-213 747.3 Nitrospirae Bacteria 3J19C@40117,COG1538@1,COG1538@2 NA|NA|NA MU Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_03587 330214.NIDE2716 2.3e-77 295.4 Bacteria narP ko:K02479,ko:K07684,ko:K07685 ko02020,map02020 M00471,M00472 ko00000,ko00001,ko00002,ko02022 Bacteria COG2197@1,COG2197@2 NA|NA|NA K response regulator MAG.T1.5_03589 330214.NIDE2714 5e-75 287.3 Nitrospirae nusG GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 ko:K02601,ko:K05785 ko00000,ko03000,ko03009,ko03021 Bacteria 3J17S@40117,COG0250@1,COG0250@2 NA|NA|NA K Transcription termination factor nusG MAG.T1.5_03590 330214.NIDE2713 1.5e-30 138.7 Bacteria ko:K07483,ko:K07497 ko00000 Bacteria COG2963@1,COG2963@2 NA|NA|NA L transposase activity MAG.T1.5_03592 330214.NIDE2712 4.3e-259 900.2 Bacteria ko:K20920 ko05111,map05111 ko00000,ko00001,ko02000 1.B.66.3.1,1.B.66.3.2 Bacteria COG5338@1,COG5338@2 NA|NA|NA P Protein conserved in bacteria MAG.T1.5_03593 330214.NIDE2711 0.0 1191.0 Bacteria ywqD 2.7.10.1 ko:K08252,ko:K13661,ko:K16554 ko05111,map05111 ko00000,ko00001,ko01000,ko02000 8.A.3.1 Bacteria COG0489@1,COG0489@2,COG3206@1,COG3206@2 NA|NA|NA M extracellular polysaccharide biosynthetic process MAG.T1.5_03594 330214.NIDE2710 4.8e-196 690.6 Bacteria ko:K03980 ko00000,ko01011,ko02000 2.A.66.4 Bacteria COG0728@1,COG0728@2 NA|NA|NA M peptidoglycan biosynthetic process MAG.T1.5_03595 330214.NIDE2704 2.4e-92 345.9 Bacteria amsD GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008378,GO:0008610,GO:0008653,GO:0008921,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035250,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.4.1.187 ko:K05946,ko:K16701 ko05111,map05111 ko00000,ko00001,ko01000,ko01003 GT26,GT4 Bacteria COG0438@1,COG0438@2 NA|NA|NA M transferase activity, transferring glycosyl groups MAG.T1.5_03596 330214.NIDE2703 5.5e-161 573.9 Bacteria Bacteria COG0438@1,COG0438@2 NA|NA|NA M transferase activity, transferring glycosyl groups MAG.T1.5_03597 330214.NIDE2702 6e-97 361.3 Bacteria ko:K18814 ko00000,ko02000 9.B.67.1 Bacteria COG3307@1,COG3307@2 NA|NA|NA M -O-antigen MAG.T1.5_03598 41431.PCC8801_2281 7.4e-82 311.2 Cyanothece Bacteria 1G060@1117,3KHHI@43988,COG2755@1,COG2755@2 NA|NA|NA E GDSL-like Lipase/Acylhydrolase MAG.T1.5_03599 330214.NIDE2720 1.5e-130 473.0 Bacteria 3.2.1.202 ko:K21606 ko00000,ko01000 CBM5,GH18 Bacteria COG3866@1,COG3866@2 NA|NA|NA G Pectate lyase MAG.T1.5_03600 330214.NIDE2700 1.7e-170 605.5 Bacteria wbpT ko:K13003 ko00000,ko01000,ko01003,ko01005 GT4 Bacteria COG0438@1,COG0438@2 NA|NA|NA M transferase activity, transferring glycosyl groups MAG.T1.5_03601 330214.NIDE2699 1.4e-281 975.3 Bacteria asnB 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 R00578 RC00010 ko00000,ko00001,ko01000,ko01002 Bacteria COG0367@1,COG0367@2 NA|NA|NA E asparagine synthase MAG.T1.5_03602 1230476.C207_02141 4e-42 178.7 Alphaproteobacteria Bacteria 1N62D@1224,2E2DZ@1,2UENG@28211,32XIP@2 NA|NA|NA MAG.T1.5_03603 330214.NIDE2698 5.5e-154 550.4 Bacteria Bacteria COG0726@1,COG0726@2 NA|NA|NA G polysaccharide deacetylase MAG.T1.5_03604 330214.NIDE2697 1.7e-197 695.3 Bacteria capM Bacteria COG0438@1,COG0438@2 NA|NA|NA M transferase activity, transferring glycosyl groups MAG.T1.5_03606 330214.NIDE2695 3.1e-218 764.2 Bacteria ko:K20306 ko00000,ko04131 Bacteria COG2755@1,COG2755@2 NA|NA|NA E lipolytic protein G-D-S-L family MAG.T1.5_03607 330214.NIDE2694 7.6e-112 409.8 Bacteria pglC GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006464,GO:0006486,GO:0006487,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0018193,GO:0018196,GO:0018279,GO:0019538,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0070085,GO:0071704,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.8.36 ko:K15915,ko:K19428 R10184 RC00002 ko00000,ko01000 Bacteria COG2148@1,COG2148@2 NA|NA|NA M undecaprenyl-phosphate glucose phosphotransferase activity MAG.T1.5_03608 330214.NIDE2693 1.2e-191 675.6 Bacteria MA20_09865 1.14.14.5 ko:K04091 ko00920,map00920 R07210,R10206 RC01779,RC02556 ko00000,ko00001,ko01000 Bacteria COG2141@1,COG2141@2 NA|NA|NA C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases MAG.T1.5_03609 330214.NIDE2692 7.4e-265 919.5 Bacteria Bacteria COG1020@1,COG1020@2 NA|NA|NA Q D-alanine [D-alanyl carrier protein] ligase activity MAG.T1.5_03610 330214.NIDE2691 1.4e-38 165.2 Bacteria pfaA 4.1.1.20,6.2.1.20 ko:K01586,ko:K01909 ko00071,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00071,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451,R01406 RC00014,RC00039,RC00299 ko00000,ko00001,ko00002,ko01000 Bacteria COG0236@1,COG0236@2 NA|NA|NA IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis MAG.T1.5_03611 330214.NIDE2690 8.3e-140 503.1 Bacteria 2.1.1.163,2.1.1.201 ko:K03183,ko:K15256 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000,ko03016 Bacteria COG0500@1,COG2226@2 NA|NA|NA Q methyltransferase MAG.T1.5_03612 330214.NIDE2689 7.3e-60 237.3 Bacteria Bacteria COG0110@1,COG0110@2 NA|NA|NA S O-acyltransferase activity MAG.T1.5_03613 330214.NIDE2688 9.9e-200 702.6 Bacteria Bacteria COG2348@1,COG2348@2 NA|NA|NA V transferase activity, transferring amino-acyl groups MAG.T1.5_03614 330214.NIDE2687 3.5e-93 348.2 Bacteria Bacteria COG0454@1,COG0456@2 NA|NA|NA K acetyltransferase MAG.T1.5_03615 330214.NIDE2686 2e-69 268.5 Bacteria Bacteria COG1853@1,COG1853@2 NA|NA|NA S FMN binding MAG.T1.5_03616 330214.NIDE2685 9.6e-195 686.0 Nitrospirae vioA GO:0005575,GO:0005576,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009607,GO:0009987,GO:0009991,GO:0010106,GO:0019725,GO:0030003,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042592,GO:0042594,GO:0043207,GO:0044403,GO:0044419,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071496,GO:0075136,GO:0098771 2.6.1.33 ko:K13308,ko:K20429 ko00523,ko01130,map00523,map01130 M00797 R02773 RC00006,RC00781 ko00000,ko00001,ko00002,ko01000 Bacteria 3J09X@40117,COG0399@1,COG0399@2 NA|NA|NA E Belongs to the DegT DnrJ EryC1 family MAG.T1.5_03617 330214.NIDE2684 7.8e-35 153.3 Bacteria Bacteria COG1434@1,COG1434@2 NA|NA|NA S Gram-negative-bacterium-type cell wall biogenesis MAG.T1.5_03618 330214.NIDE2683 0.0 1205.3 Bacteria capD GO:0008150,GO:0043900,GO:0043902,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0065007,GO:1900190,GO:1900192 4.2.1.115,4.2.1.135,4.2.1.46 ko:K01710,ko:K15894,ko:K15912,ko:K19421 ko00520,ko00521,ko00523,ko00525,ko01055,ko01130,map00520,map00521,map00523,map00525,map01055,map01130 M00793 R06513,R09697 RC00402,RC02609 ko00000,ko00001,ko00002,ko01000 Bacteria COG1086@1,COG1086@2 NA|NA|NA GM Polysaccharide biosynthesis protein MAG.T1.5_03619 330214.NIDE2682 1.1e-122 446.0 Bacteria ko:K01991,ko:K20988 ko02026,ko05111,map02026,map05111 ko00000,ko00001,ko02000 1.B.18 Bacteria COG1596@1,COG1596@2 NA|NA|NA M polysaccharide export MAG.T1.5_03622 330214.NIDE1448 1.4e-88 332.8 Bacteria ung GO:0003674,GO:0003824,GO:0004844,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0097510,GO:0140097,GO:1901360 3.2.2.27 ko:K03648 ko03410,ko05340,map03410,map05340 ko00000,ko00001,ko01000,ko03400 Bacteria COG0692@1,COG0692@2 NA|NA|NA L deaminated base DNA N-glycosylase activity MAG.T1.5_03627 330214.NIDE1468 2.6e-196 691.8 Nitrospirae Bacteria 3J1AF@40117,COG0457@1,COG0457@2 NA|NA|NA S Evidence 5 No homology to any previously reported sequences MAG.T1.5_03629 330214.NIDE1470 9.1e-29 133.3 Bacteria ko:K21572 ko00000,ko02000 8.A.46.1,8.A.46.3 Bacteria COG2913@1,COG2913@2 NA|NA|NA J Gram-negative-bacterium-type cell outer membrane assembly MAG.T1.5_03631 330214.NIDE1472 2.6e-212 744.6 Nitrospirae rhlE 3.6.4.13 ko:K11927 ko03018,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 3J0ZA@40117,COG0513@1,COG0513@2 NA|NA|NA F helicase superfamily c-terminal domain MAG.T1.5_03634 330214.NIDE1475 1.5e-254 885.2 Nitrospirae fhlA ko:K02584,ko:K12266,ko:K15836,ko:K21009 ko02020,ko02025,ko05132,map02020,map02025,map05132 ko00000,ko00001,ko03000 Bacteria 3J1FR@40117,COG2203@1,COG2203@2,COG3829@1,COG3829@2 NA|NA|NA KT Evidence 2b Function of strongly homologous gene MAG.T1.5_03635 330214.NIDE4073 4.9e-150 538.1 Bacteria VPA1441 Bacteria COG3203@1,COG3203@2 NA|NA|NA M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane MAG.T1.5_03637 330214.NIDE1479 2e-116 425.2 Bacteria Bacteria COG3000@1,COG3000@2 NA|NA|NA I iron ion binding MAG.T1.5_03638 330214.NIDE1480 4.6e-138 497.7 Nitrospirae dpm1 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 R01009 RC00005 ko00000,ko00001,ko01000,ko01003 GT2 Bacteria 3J16X@40117,COG0463@1,COG0463@2,COG2246@1,COG2246@2 NA|NA|NA M Glycosyl transferase family 2 MAG.T1.5_03639 330214.NIDE1481 1.4e-186 659.4 Bacteria Bacteria COG4993@1,COG4993@2 NA|NA|NA G Dehydrogenase MAG.T1.5_03640 330214.NIDE1482 6.7e-191 673.3 Bacteria mltC GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008932,GO:0008933,GO:0009056,GO:0009057,GO:0009253,GO:0009279,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0019867,GO:0030203,GO:0030288,GO:0030312,GO:0030313,GO:0031224,GO:0031225,GO:0031975,GO:0033554,GO:0034599,GO:0042221,GO:0042597,GO:0043170,GO:0044425,GO:0044462,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0061783,GO:0070887,GO:0071236,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 ko:K08306,ko:K08308,ko:K08309 ko00000,ko01000,ko01011 GH23 iAF1260.b1193,iB21_1397.B21_01178,iBWG_1329.BWG_1018,iECBD_1354.ECBD_2429,iECB_1328.ECB_01168,iECDH10B_1368.ECDH10B_1246,iECDH1ME8569_1439.ECDH1ME8569_1132,iECD_1391.ECD_01168,iEcDH1_1363.EcDH1_2455,iEcolC_1368.EcolC_2432,iG2583_1286.G2583_3622,iJO1366.b1193,iUMNK88_1353.UMNK88_1507,iUMNK88_1353.UMNK88_3661,iY75_1357.Y75_RS06225 Bacteria COG0741@1,COG0741@2 NA|NA|NA M lytic transglycosylase activity MAG.T1.5_03641 330214.NIDE1483 1.5e-59 236.1 Bacteria ttg2D ko:K07323 ko02010,map02010 M00210 ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 Bacteria COG2854@1,COG2854@2 NA|NA|NA Q intermembrane phospholipid transfer MAG.T1.5_03642 330214.NIDE1484 9.4e-39 167.2 Bacteria narP ko:K02479,ko:K07684,ko:K07685 ko02020,map02020 M00471,M00472 ko00000,ko00001,ko00002,ko02022 Bacteria COG2197@1,COG2197@2 NA|NA|NA K response regulator MAG.T1.5_03644 330214.NIDE1487 5e-27 127.5 Bacteria Bacteria COG0784@1,COG0784@2 NA|NA|NA T Response regulator, receiver MAG.T1.5_03646 330214.NIDE1489 5e-95 354.0 Nitrospirae vsrD2 ko:K02282,ko:K07689 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 M00475 ko00000,ko00001,ko00002,ko02022,ko02035,ko02044 Bacteria 3J12Q@40117,COG2197@1,COG2197@2 NA|NA|NA K Product type r regulator MAG.T1.5_03647 330214.NIDE1491 2.1e-281 974.9 Nitrospirae exsG 2.7.13.3 ko:K07675 ko02020,map02020 M00473 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 3J12P@40117,COG0745@1,COG0745@2,COG2202@1,COG2202@2,COG3829@1,COG3829@2,COG4585@1,COG4585@2,COG5002@1,COG5002@2 NA|NA|NA T Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_03648 1242864.D187_002317 4e-54 217.6 Myxococcales rcp1 ko:K02485,ko:K11355 ko02020,map02020 M00510 ko00000,ko00001,ko00002,ko02022 Bacteria 1QUN7@1224,2WS98@28221,2YV93@29,42VIG@68525,COG0784@1,COG0784@2 NA|NA|NA T cheY-homologous receiver domain MAG.T1.5_03649 330214.NIDE1493 1.2e-226 792.7 Nitrospirae Bacteria 3J0Y3@40117,COG4251@1,COG4251@2 NA|NA|NA T His Kinase A (phosphoacceptor) domain MAG.T1.5_03650 330214.NIDE1494 7.7e-49 199.9 Bacteria yaeJ GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0003824,GO:0004045,GO:0005488,GO:0006412,GO:0006414,GO:0006415,GO:0006417,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016150,GO:0016787,GO:0016788,GO:0019222,GO:0019538,GO:0022411,GO:0031323,GO:0031326,GO:0032268,GO:0032984,GO:0034248,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0052689,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0140098,GO:0140101,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112 ko:K15034 ko00000,ko03012 Bacteria COG1186@1,COG1186@2 NA|NA|NA J translation release factor activity MAG.T1.5_03651 330214.NIDE1495 3e-37 161.0 Bacteria rbpA Bacteria COG0724@1,COG0724@2 NA|NA|NA K RNA recognition motif MAG.T1.5_03652 330214.NIDE1497 7.7e-168 596.3 Bacteria desC 1.14.19.1 ko:K00507 ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212 R02222 RC00917 ko00000,ko00001,ko01000,ko01004 Bacteria COG1398@1,COG1398@2 NA|NA|NA I oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water MAG.T1.5_03655 330214.NIDE1500 2.5e-156 558.1 Nitrospirae lpxL 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 Bacteria 3J0SH@40117,COG1560@1,COG1560@2 NA|NA|NA M Bacterial lipid A biosynthesis acyltransferase MAG.T1.5_03658 330214.NIDE1503 3.1e-110 404.8 Nitrospirae ko:K02066 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 3J0P4@40117,COG0767@1,COG0767@2 NA|NA|NA Q Permease MlaE MAG.T1.5_03659 330214.NIDE1504 3.7e-86 324.7 Bacteria ttg2A ko:K02065 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria COG1127@1,COG1127@2 NA|NA|NA Q ATPase activity MAG.T1.5_03660 330214.NIDE1505 9.3e-93 347.1 Nitrospirae ycf22 ko:K02067 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 3J0VP@40117,COG1463@1,COG1463@2 NA|NA|NA Q MlaD protein MAG.T1.5_03662 330214.NIDE1508 0.0 1458.4 Nitrospirae gspE2 ko:K02652 ko00000,ko02035,ko02044 3.A.15.2 Bacteria 3J0XR@40117,COG2203@1,COG2203@2,COG2804@1,COG2804@2 NA|NA|NA NU Type II/IV secretion system protein MAG.T1.5_03663 330214.NIDE1509 5.2e-282 976.5 Nitrospirae proS GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0043906,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iJN678.proS,iUTI89_1310.UTI89_C0210 Bacteria 3J0EY@40117,COG0442@1,COG0442@2 NA|NA|NA J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS MAG.T1.5_03664 330214.NIDE1510 2.8e-252 877.5 Nitrospirae rseP 3.4.21.107 ko:K04771,ko:K11749 ko01503,ko02020,ko02024,ko04112,map01503,map02020,map02024,map04112 M00728 ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 Bacteria 3J0GI@40117,COG0750@1,COG0750@2 NA|NA|NA M Peptidase family M50 MAG.T1.5_03665 330214.NIDE1511 1.2e-195 689.1 Nitrospirae dxr GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0050897,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 iAPECO1_1312.APECO1_1814,iECOK1_1307.ECOK1_0174,iECS88_1305.ECS88_0183,iHN637.CLJU_RS06420,iNJ661.Rv2870c,iUMN146_1321.UM146_23670,iUTI89_1310.UTI89_C0188 Bacteria 3J0B0@40117,COG0743@1,COG0743@2 NA|NA|NA I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) MAG.T1.5_03666 330214.NIDE1512 2.2e-122 445.3 Nitrospirae cdsA GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0044464,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 3J1FV@40117,COG4589@1,COG4589@2 NA|NA|NA I Cytidylyltransferase family MAG.T1.5_03667 330214.NIDE1513 8.1e-132 476.5 Nitrospirae uppS GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008834,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0050347,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617 2.5.1.31,2.5.1.86,2.5.1.88 ko:K00806,ko:K14215,ko:K21273 ko00900,ko01110,map00900,map01110 R06447,R09244,R09731 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 iLJ478.TM1398 Bacteria 3J0HJ@40117,COG0020@1,COG0020@2 NA|NA|NA H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids MAG.T1.5_03668 330214.NIDE1514 3.4e-261 907.1 Nitrospirae tldD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564 ko:K03568 ko00000,ko01002 Bacteria 3J0F9@40117,COG0312@1,COG0312@2 NA|NA|NA S Putative modulator of DNA gyrase MAG.T1.5_03669 330214.NIDE1515 6.7e-235 819.7 Nitrospirae pmbA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564 ko:K03592 ko00000,ko01002 Bacteria 3J0P7@40117,COG0312@1,COG0312@2 NA|NA|NA S Putative modulator of DNA gyrase MAG.T1.5_03671 330214.NIDE1518 6.3e-101 373.6 Nitrospirae 3.2.2.27 ko:K21929 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 3J0MR@40117,COG1573@1,COG1573@2 NA|NA|NA L Uracil DNA glycosylase superfamily MAG.T1.5_03672 330214.NIDE1519 3.4e-191 674.5 Nitrospirae 1.3.5.5 ko:K02293 ko00906,ko01100,ko01110,map00906,map01100,map01110 M00097 R04786,R04787,R07510,R09652,R09653,R09654 RC01214,RC01958,RC03092,RC03093 ko00000,ko00001,ko00002,ko01000 Bacteria 3J1ES@40117,COG1232@1,COG1232@2 NA|NA|NA C Flavin containing amine oxidoreductase MAG.T1.5_03673 330214.NIDE1520 1.3e-149 535.8 Nitrospirae crtB 2.5.1.32,2.5.1.99 ko:K02291 ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110 M00097 R02065,R04218,R07270,R10177 RC00362,RC01101,RC02869 ko00000,ko00001,ko00002,ko01000,ko01006 Bacteria 3J17J@40117,COG1562@1,COG1562@2 NA|NA|NA I Squalene/phytoene synthase MAG.T1.5_03674 330214.NIDE1521 4.7e-123 447.6 Bacteria ko:K02016 ko02010,map02010 M00240 ko00000,ko00001,ko00002,ko02000 3.A.1.14 Bacteria COG0614@1,COG0614@2 NA|NA|NA P abc-type fe3 -hydroxamate transport system, periplasmic component MAG.T1.5_03675 330214.NIDE1522 6.6e-109 400.2 Nitrospirae yieH 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 R01334 RC00017 ko00000,ko00001,ko01000 Bacteria 3J15X@40117,COG0637@1,COG0637@2 NA|NA|NA S Haloacid dehalogenase-like hydrolase MAG.T1.5_03677 330214.NIDE1525 8.2e-67 259.6 Nitrospirae Bacteria 3J1CB@40117,COG0432@1,COG0432@2 NA|NA|NA S Uncharacterised protein family UPF0047 MAG.T1.5_03679 330214.NIDE1527 3.3e-48 198.4 Bacteria ko:K18491 ko04550,map04550 ko00000,ko00001,ko03000 Bacteria COG3266@1,COG3266@2 NA|NA|NA GM domain, Protein MAG.T1.5_03680 330214.NIDE1528 8.7e-72 276.9 Bacteria Bacteria COG1716@1,COG1716@2 NA|NA|NA T histone H2A K63-linked ubiquitination MAG.T1.5_03681 330214.NIDE1529 1.6e-101 375.9 Bacteria 3.1.3.16 ko:K01090,ko:K20074 ko00000,ko01000,ko01009 Bacteria COG0631@1,COG0631@2 NA|NA|NA T protein serine/threonine phosphatase activity MAG.T1.5_03682 1122604.JONR01000001_gene1979 6.2e-82 311.6 Xanthomonadales 2.7.11.1 ko:K12132 ko00000,ko01000,ko01001 Bacteria 1MV1P@1224,1RR36@1236,1X6T3@135614,COG0515@1,COG0515@2,COG4252@1,COG4252@2 NA|NA|NA KLT Protein tyrosine kinase MAG.T1.5_03683 330214.NIDE1531 3.4e-144 517.7 Bacteria trpH 3.1.3.97,4.1.2.13 ko:K01624,ko:K07053 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R00188,R01068,R01070,R01829,R02568,R11188 RC00078,RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 Bacteria COG0613@1,COG0613@2 NA|NA|NA Q PHP domain protein MAG.T1.5_03684 330214.NIDE1532 4.9e-128 464.2 Bacteria folB 1.13.11.81,2.1.1.228,3.1.3.18,4.1.2.25,5.1.99.8 ko:K01091,ko:K01633,ko:K15429 ko00630,ko00790,ko01100,ko01110,ko01130,map00630,map00790,map01100,map01110,map01130 M00126,M00840 R00597,R01334,R03504,R11037,R11073 RC00003,RC00017,RC00334,RC00721,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000,ko03016 Bacteria COG1539@1,COG1539@2,COG2520@1,COG2520@2 NA|NA|NA J tRNA (guanine(37)-N(1))-methyltransferase activity MAG.T1.5_03687 330214.NIDE1537 2.6e-134 485.0 Bacteria ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 Bacteria COG4249@1,COG4249@2 NA|NA|NA S B-1 B cell differentiation MAG.T1.5_03688 330214.NIDE2499 5.7e-26 122.9 Bacteria Bacteria 2EQJE@1,33I5F@2 NA|NA|NA S Protein of unknown function (DUF2281) MAG.T1.5_03689 330214.NIDE2500 1.1e-14 85.1 Bacteria ko:K07171 ko00000,ko01000,ko02048 Bacteria COG2337@1,COG2337@2 NA|NA|NA T Toxic component of a toxin-antitoxin (TA) module MAG.T1.5_03692 243231.GSU0051 3.3e-297 1027.7 Deltaproteobacteria cas3 ko:K07012 ko00000,ko01000,ko02048 Bacteria 1R8FD@1224,2WMHK@28221,42NNV@68525,COG1203@1,COG1203@2 NA|NA|NA L TIGRFAM CRISPR-associated helicase Cas3 MAG.T1.5_03693 1123242.JH636435_gene1722 1e-36 160.6 Planctomycetes cas3 ko:K07012 ko00000,ko01000,ko02048 Bacteria 2IXEG@203682,COG1203@1,COG1203@2 NA|NA|NA L CRISPR-associated helicase, Cas3 MAG.T1.5_03694 243231.GSU0053 2.1e-130 472.2 Deltaproteobacteria csb1 ko:K19131 ko00000,ko02048 Bacteria 1RBTZ@1224,28KC2@1,2WT79@28221,2Z9Z2@2,42XV5@68525 NA|NA|NA S CRISPR-associated protein GSU0053 (Cas_GSU0053) MAG.T1.5_03695 243231.GSU0054 1.1e-172 613.2 Proteobacteria ko:K19132 ko00000,ko02048 Bacteria 1RD13@1224,2DBHK@1,2Z9AT@2 NA|NA|NA S CRISPR-associated protein, GSU0054 family (Cas_GSU0054) MAG.T1.5_03696 330214.NIDE1553 3.1e-22 110.9 Bacteria Bacteria 2ECNM@1,336KG@2 NA|NA|NA MAG.T1.5_03697 671143.DAMO_1792 1.1e-48 199.9 Bacteria Bacteria COG4636@1,COG4636@2 NA|NA|NA D protein conserved in cyanobacteria MAG.T1.5_03698 671143.DAMO_2735 2.1e-201 708.8 unclassified Bacteria cas1 GO:0000738,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005488,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008297,GO:0008409,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0030145,GO:0034641,GO:0034655,GO:0035312,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045145,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575 3.1.12.1 ko:K07464,ko:K15342 ko00000,ko01000,ko02048,ko03400 Bacteria 2NPPQ@2323,COG1468@1,COG1468@2,COG1518@1,COG1518@2 NA|NA|NA L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette MAG.T1.5_03699 671143.DAMO_2734 5.8e-19 100.1 Bacteria cas2 ko:K09951 ko00000,ko02048 Bacteria COG1343@1,COG1343@2 NA|NA|NA L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette MAG.T1.5_03700 330214.NIDE1715 3.7e-61 241.9 Bacteria Bacteria COG3209@1,COG3209@2 NA|NA|NA M self proteolysis MAG.T1.5_03702 1080067.BAZH01000041_gene2605 7.1e-14 84.7 Citrobacter ylpA Bacteria 1RD8I@1224,1RZE6@1236,2C2AA@1,2ZAYY@2,3WWJI@544 NA|NA|NA S Enterobacterial TraT complement resistance protein MAG.T1.5_03703 234267.Acid_2792 9.7e-48 198.7 Acidobacteria 2.7.13.3 ko:K07683 ko02020,map02020 M00483 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 3Y4XJ@57723,COG2202@1,COG2202@2,COG4585@1,COG4585@2 NA|NA|NA T Histidine kinase MAG.T1.5_03704 330214.NIDE3247 1.7e-35 156.4 Bacteria ko:K02282 ko00000,ko02035,ko02044 Bacteria COG2197@1,COG2197@2 NA|NA|NA K response regulator MAG.T1.5_03706 1123508.JH636442_gene4333 4.7e-139 501.5 Bacteria Bacteria COG0827@1,COG0827@2 NA|NA|NA L DNA restriction-modification system MAG.T1.5_03707 1347393.HG726024_gene2967 3.4e-08 66.2 Bacteroidaceae Bacteria 2FPER@200643,4AP08@815,4NH5X@976,COG0358@1,COG0358@2 NA|NA|NA L DNA primase MAG.T1.5_03708 1340493.JNIF01000004_gene1144 4.3e-36 158.7 Acidobacteria Bacteria 28KVW@1,2ZACC@2,3Y8V3@57723 NA|NA|NA MAG.T1.5_03711 1340493.JNIF01000004_gene1160 1e-114 420.6 Bacteria Bacteria COG0464@1,COG0464@2 NA|NA|NA O ATPase activity MAG.T1.5_03714 909663.KI867150_gene2752 3.8e-132 478.4 Syntrophobacterales traD ko:K12071 ko00000,ko02044 3.A.7.11.1 Bacteria 1MVGD@1224,2MQV5@213462,2WKY7@28221,42M9J@68525,COG3505@1,COG3505@2 NA|NA|NA U TraM recognition site of TraD and TraG MAG.T1.5_03715 289376.THEYE_A0571 2.8e-45 189.5 Nitrospirae rip3 GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0031224,GO:0031226,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 ko:K06212,ko:K06402 ko00000,ko01000,ko01002,ko02000 1.A.16.1.1,1.A.16.1.3 Bacteria 3J0VG@40117,COG0517@1,COG0517@2,COG1994@1,COG1994@2 NA|NA|NA S Belongs to the peptidase M50B family MAG.T1.5_03717 330214.NIDE1291 3.3e-148 532.3 Nitrospirae pcrA 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 3J0VX@40117,COG0210@1,COG0210@2 NA|NA|NA L UvrD-like helicase C-terminal domain MAG.T1.5_03719 909663.KI867150_gene2756 2.3e-15 90.1 Bacteria ko:K03497 ko00000,ko03000,ko03036,ko04812 Bacteria COG1475@1,COG1475@2 NA|NA|NA K chromosome segregation MAG.T1.5_03724 1123376.AUIU01000017_gene148 4e-46 192.6 Bacteria Bacteria COG4570@1,COG4570@2 NA|NA|NA L crossover junction endodeoxyribonuclease activity MAG.T1.5_03726 706587.Desti_0528 5.2e-33 149.4 Syntrophobacterales recD2 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 2.7.7.7,3.1.11.5,6.5.1.2 ko:K01972,ko:K02342,ko:K02600,ko:K03581 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03430,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03430,map03440 M00260 R00375,R00376,R00377,R00378,R00382 RC00005,RC02795 ko00000,ko00001,ko00002,ko01000,ko03009,ko03021,ko03032,ko03400 Bacteria 1MW43@1224,2MQAU@213462,2WJD6@28221,42M8J@68525,COG0272@1,COG0272@2,COG0507@1,COG0507@2 NA|NA|NA L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity MAG.T1.5_03734 1158165.KB898873_gene378 7.6e-08 63.2 Proteobacteria traL ko:K12068 ko00000,ko02044 3.A.7.11.1 Bacteria 1NHEH@1224,2EJSV@1,33DHH@2 NA|NA|NA S TraL protein MAG.T1.5_03735 1230343.CANP01000012_gene1089 1.2e-07 63.5 Legionellales traE ko:K12067 ko00000,ko02044 3.A.7.11.1 Bacteria 1JDX9@118969,1NC2W@1224,1SEQC@1236,2DPUP@1,333FI@2 NA|NA|NA S TraE protein MAG.T1.5_03737 1123392.AQWL01000010_gene2341 1.2e-39 171.0 Betaproteobacteria traB ko:K12065,ko:K15051 ko00000,ko02044 3.A.7.11.1 Bacteria 1QUPW@1224,2VMWY@28216,COG2433@1,COG2433@2 NA|NA|NA S Bacterial conjugation TrbI-like protein MAG.T1.5_03738 349521.HCH_01777 1.1e-27 130.6 Oceanospirillales dsbC 5.3.4.1 ko:K03981 ko00000,ko01000,ko02044,ko03110 3.A.7.11.1 Bacteria 1RD39@1224,1S3U8@1236,1XJNT@135619,COG1651@1,COG1651@2 NA|NA|NA O Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process MAG.T1.5_03740 1158165.KB898873_gene372 8.4e-114 418.3 Chromatiales traG ko:K12063 ko00000,ko02044 3.A.7.11.1 Bacteria 1MUEN@1224,1RMMX@1236,1WXA7@135613,COG3451@1,COG3451@2 NA|NA|NA U TIGRFAM type-IV secretion system protein TraC MAG.T1.5_03741 420662.Mpe_B0373 9.3e-14 83.6 Betaproteobacteria trhF 3.4.21.89 ko:K03100,ko:K12062,ko:K13280 ko02024,ko03060,map02024,map03060 ko00000,ko00001,ko01000,ko01002,ko02044 3.A.7.11.1 Bacteria 1R3QJ@1224,2VYNI@28216,COG0681@1,COG0681@2 NA|NA|NA U Belongs to the peptidase S26 family MAG.T1.5_03742 272624.lpg2086 1e-21 111.3 Legionellales traW ko:K12061 ko00000,ko02044 3.A.7.11.1 Bacteria 1JCGT@118969,1N1MK@1224,1S72B@1236,2CGUX@1,31QWG@2 NA|NA|NA S Type-F conjugative transfer system protein TraW MAG.T1.5_03743 91604.ID47_01355 2.5e-59 236.1 Rickettsiales traU ko:K12060 ko00000,ko02044 3.A.7.11.1 Bacteria 1MXUA@1224,28HGF@1,2U2HG@28211,2Z7SA@2,47EWU@766 NA|NA|NA S TraU protein MAG.T1.5_03744 1454004.AW11_01152 2.9e-32 146.0 Betaproteobacteria traF ko:K12057 ko00000,ko02044 3.A.7.11.1 Bacteria 1MXG2@1224,2VMSV@28216,COG0526@1,COG0526@2 NA|NA|NA CO F plasmid transfer operon protein MAG.T1.5_03745 216591.pBCA021 5.8e-26 125.6 Burkholderiaceae traH ko:K12072 ko00000,ko02044 3.A.7.11.1 Bacteria 1K6PW@119060,1MWD0@1224,28MTB@1,2VQE5@28216,2ZB1J@2 NA|NA|NA S Conjugative relaxosome accessory transposon protein MAG.T1.5_03746 1335760.ASTG01000021_gene2817 6e-22 114.0 Sphingomonadales traG ko:K12056 ko00000,ko02044 3.A.7.11.1 Bacteria 1MXCR@1224,2K1QI@204457,2U372@28211,COG4678@1,COG4678@2 NA|NA|NA G TraG-like protein, N-terminal region MAG.T1.5_03748 909663.KI867150_gene2751 1.2e-27 130.2 Bacteria nusA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 ko:K02600,ko:K02945 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03009,ko03011,ko03021 Bacteria COG0195@1,COG0195@2 NA|NA|NA K DNA-templated transcription, termination MAG.T1.5_03751 706436.HMPREF9074_08785 4.6e-08 64.7 Capnocytophaga ybjQ Bacteria 1ES7F@1016,1I4ZC@117743,4NS20@976,COG0393@1,COG0393@2 NA|NA|NA S Putative heavy-metal-binding MAG.T1.5_03752 1247963.JPHU01000016_gene1090 1.9e-24 120.2 Alphaproteobacteria traN ko:K12058 ko00000,ko02044 3.A.7.11.1 Bacteria 1MW96@1224,28KC1@1,2U6RW@28211,2Z9Z1@2 NA|NA|NA S Type-1V conjugative transfer system mating pair stabilisation MAG.T1.5_03753 547144.HydHO_0550 3.3e-21 108.6 Aquificae Bacteria 2G523@200783,COG0741@1,COG0741@2 NA|NA|NA M Transglycosylase SLT domain MAG.T1.5_03755 909663.KI867150_gene2694 1.7e-44 187.2 Syntrophobacterales ko:K03406,ko:K07038 ko02020,ko02030,map02020,map02030 ko00000,ko00001,ko02035 Bacteria 1QVAN@1224,2MS79@213462,2X711@28221,43BPT@68525,COG1988@1,COG1988@2 NA|NA|NA S Metal dependent phosphohydrolases with conserved 'HD' motif. MAG.T1.5_03757 909663.KI867150_gene2692 7.3e-26 124.4 Syntrophobacterales Bacteria 1NE8C@1224,2D767@1,2MRY2@213462,2WRXS@28221,32TNE@2,42VAK@68525 NA|NA|NA MAG.T1.5_03758 1149133.ppKF707_0392 1.6e-82 312.4 Gammaproteobacteria res 3.1.21.5 ko:K01156 ko00000,ko01000,ko02048 Bacteria 1MVQ0@1224,1RPN2@1236,COG3587@1,COG3587@2 NA|NA|NA L Type III MAG.T1.5_03760 298653.Franean1_0045 4.3e-187 662.5 Actinobacteria Bacteria 2IBIZ@201174,COG1073@1,COG1073@2 NA|NA|NA L photosystem II stabilization MAG.T1.5_03762 298653.Franean1_0043 4.4e-219 769.2 Actinobacteria Bacteria 2IBIZ@201174,COG1073@1,COG1073@2 NA|NA|NA L photosystem II stabilization MAG.T1.5_03765 330214.NIDE3547 7.3e-100 370.2 Nitrospirae Bacteria 3J133@40117,COG0582@1,COG0582@2 NA|NA|NA L Belongs to the 'phage' integrase family MAG.T1.5_03766 330214.NIDE0293 3.3e-23 114.4 Bacteria ko:K02806 ko02060,map02060 ko00000,ko00001,ko01000,ko02000 Bacteria COG3311@1,COG3311@2 NA|NA|NA K DNA excision MAG.T1.5_03767 330214.NIDE2680 9.9e-18 95.1 Bacteria gumB ko:K01991 ko02026,map02026 ko00000,ko00001,ko02000 1.B.18 Bacteria COG1596@1,COG1596@2 NA|NA|NA M polysaccharide export MAG.T1.5_03768 330214.NIDE2678 3.6e-42 177.6 Bacteria ko:K06186 ko00000,ko02000 1.B.33.1 Bacteria COG2913@1,COG2913@2 NA|NA|NA J Gram-negative-bacterium-type cell outer membrane assembly MAG.T1.5_03769 330214.NIDE2676 5.8e-31 139.8 Nitrospirae ko:K15383 ko00000,ko02000 9.A.58.2 Bacteria 3J0UA@40117,COG4095@1,COG4095@2 NA|NA|NA S PQ loop repeat MAG.T1.5_03770 330214.NIDE2674 3.9e-160 570.9 Nitrospirae ko:K02016 ko02010,map02010 M00240 ko00000,ko00001,ko00002,ko02000 3.A.1.14 Bacteria 3J173@40117,COG0614@1,COG0614@2 NA|NA|NA P Periplasmic binding protein MAG.T1.5_03771 330214.NIDE2673 9.6e-182 642.9 Nitrospirae ko:K02015 ko02010,map02010 M00240 ko00000,ko00001,ko00002,ko02000 3.A.1.14 Bacteria 3J11Y@40117,COG0609@1,COG0609@2 NA|NA|NA P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily MAG.T1.5_03772 330214.NIDE2672 1.6e-152 545.4 Nitrospirae hmuV 3.6.3.34 ko:K02013 ko02010,map02010 M00240 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 Bacteria 3J14U@40117,COG1120@1,COG1120@2 NA|NA|NA HP ABC transporter MAG.T1.5_03773 330214.NIDE2671 0.0 1159.4 Bacteria btuB ko:K02014,ko:K16092 ko00000,ko02000 1.B.14,1.B.14.3 Bacteria COG4206@1,COG4206@2 NA|NA|NA H cobalamin-transporting ATPase activity MAG.T1.5_03774 330214.NIDE2670 2.7e-223 781.2 Nitrospirae cobB 6.3.5.11,6.3.5.9 ko:K02224 ko00860,ko01100,ko01120,map00860,map01100,map01120 R05224,R05815 RC00010,RC01301 ko00000,ko00001,ko01000 iAF987.Gmet_0470 Bacteria 3J0HM@40117,COG1797@1,COG1797@2 NA|NA|NA H Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source MAG.T1.5_03775 330214.NIDE2669 2.5e-101 374.8 Nitrospirae cobO GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008817,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019250,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.17 ko:K16092,ko:K19221 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000,ko02000 1.B.14.3 iAF1260.b1270,iB21_1397.B21_01256,iBWG_1329.BWG_1099,iECABU_c1320.ECABU_c15500,iECBD_1354.ECBD_2352,iECB_1328.ECB_01246,iECDH10B_1368.ECDH10B_1385,iECDH1ME8569_1439.ECDH1ME8569_1209,iECD_1391.ECD_01246,iECIAI1_1343.ECIAI1_1288,iECO111_1330.ECO111_1649,iECO26_1355.ECO26_1834,iETEC_1333.ETEC_1372,iEcDH1_1363.EcDH1_2379,iEcHS_1320.EcHS_A1379,iJO1366.b1270,iJR904.b1270,iLF82_1304.LF82_0253,iNRG857_1313.NRG857_06515,iUMNK88_1353.UMNK88_1599,iY75_1357.Y75_RS06640,iYL1228.KPN_01266,ic_1306.c1735 Bacteria 3J0NJ@40117,COG2109@1,COG2109@2 NA|NA|NA H ATP:corrinoid adenosyltransferase BtuR/CobO/CobP MAG.T1.5_03776 330214.NIDE2666 5.4e-96 357.1 Bacteria yvqK GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005525,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016043,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019003,GO:0019438,GO:0019538,GO:0022607,GO:0030091,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033013,GO:0033014,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.2.1.88,1.5.5.2,2.5.1.17 ko:K00798,ko:K13821 ko00250,ko00330,ko00860,ko01100,ko01110,ko01130,map00250,map00330,map00860,map01100,map01110,map01130 M00122 R00245,R00707,R00708,R01253,R01492,R04444,R04445,R05051,R05220,R07268 RC00080,RC00083,RC00216,RC00242,RC00255,RC00533 ko00000,ko00001,ko00002,ko01000,ko03000 Bacteria COG2096@1,COG2096@2 NA|NA|NA S cob(I)yrinic acid a,c-diamide adenosyltransferase activity MAG.T1.5_03777 330214.NIDE2665 5.3e-69 267.3 Nitrospirae cobU GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008819,GO:0008820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0033554,GO:0044237,GO:0050896,GO:0051716,GO:0070568 2.7.1.156,2.7.7.62,6.3.5.10 ko:K02231,ko:K02232 ko00860,ko01100,map00860,map01100 M00122 R05221,R05222,R05225,R06558 RC00002,RC00010,RC00428,RC01302 ko00000,ko00001,ko00002,ko01000 iECIAI1_1343.ECIAI1_2074,iECSE_1348.ECSE_2277,iECW_1372.ECW_m2165,iETEC_1333.ETEC_2103,iEcE24377_1341.EcE24377A_2275,iEcSMS35_1347.EcSMS35_1131,iEcolC_1368.EcolC_1635,iLF82_1304.LF82_0337,iSDY_1059.SDY_2240,iWFL_1372.ECW_m2165 Bacteria 3J0UG@40117,COG2087@1,COG2087@2 NA|NA|NA H Cobinamide kinase / cobinamide phosphate guanyltransferase MAG.T1.5_03778 330214.NIDE2664 8.8e-158 563.1 Nitrospirae cobT GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008939,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.21,6.3.5.11,6.3.5.9 ko:K00768,ko:K02224 ko00860,ko01100,ko01120,map00860,map01100,map01120 M00122 R04148,R05224,R05815 RC00010,RC00033,RC00063,RC01301 ko00000,ko00001,ko00002,ko01000 iSDY_1059.SDY_2242,iSF_1195.SF2059,iSFxv_1172.SFxv_2293,iS_1188.S2169 Bacteria 3J0C9@40117,COG2038@1,COG2038@2 NA|NA|NA H Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) MAG.T1.5_03779 330214.NIDE2663 6.9e-104 383.6 Nitrospirae cobS GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008818,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.8.26 ko:K02233 ko00860,ko01100,map00860,map01100 M00122 R05223,R11174 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0VC@40117,COG0368@1,COG0368@2 NA|NA|NA H Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate MAG.T1.5_03780 330214.NIDE2662 2.3e-133 481.9 Nitrospirae cobD 6.3.1.10 ko:K02227 ko00860,ko01100,map00860,map01100 M00122 R06529,R07302 RC00090,RC00096 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0K4@40117,COG1270@1,COG1270@2 NA|NA|NA H Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group MAG.T1.5_03781 330214.NIDE2661 8.7e-132 476.9 Nitrospirae cobD 2.6.1.9,4.1.1.81 ko:K00817,ko:K04720 ko00340,ko00350,ko00360,ko00400,ko00401,ko00860,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00860,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243,R06530 RC00006,RC00517,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 iAF987.Gmet_0487 Bacteria 3J138@40117,COG0079@1,COG0079@2 NA|NA|NA E Aminotransferase class I and II MAG.T1.5_03782 330214.NIDE2660 1.5e-84 319.3 Bacteria cbiZ 2.7.1.156,2.7.7.62,3.6.3.34 ko:K02013,ko:K02231 ko00860,ko01100,ko02010,map00860,map01100,map02010 M00122,M00240 R05221,R05222,R06558 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 Bacteria COG1865@1,COG1865@2 NA|NA|NA HP Adenosylcobinamide amidohydrolase MAG.T1.5_03783 330214.NIDE2659 6.9e-215 753.4 Nitrospirae cobQ 6.3.5.10 ko:K02232 ko00860,ko01100,map00860,map01100 M00122 R05225 RC00010,RC01302 ko00000,ko00001,ko00002,ko01000 iYL1228.KPN_03184 Bacteria 3J0F3@40117,COG1492@1,COG1492@2 NA|NA|NA H Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation MAG.T1.5_03784 330214.NIDE2658 6.2e-118 430.3 Bacteria Bacteria COG3267@1,COG3267@2 NA|NA|NA MAG.T1.5_03785 330214.NIDE2657 7.6e-61 239.6 Nitrospirae Bacteria 3J16K@40117,COG0745@1,COG0745@2 NA|NA|NA T cheY-homologous receiver domain MAG.T1.5_03786 330214.NIDE2656 4.9e-62 243.8 Bacteria cheW2 ko:K03408,ko:K03415 ko02020,ko02030,map02020,map02030 M00506 ko00000,ko00001,ko00002,ko02022,ko02035 Bacteria COG0835@1,COG0835@2 NA|NA|NA NT chemotaxis MAG.T1.5_03787 330214.NIDE2655 8.3e-300 1035.8 Nitrospirae mcp64H-2 ko:K02660,ko:K03406,ko:K11525 ko02020,ko02025,ko02030,map02020,map02025,map02030 ko00000,ko00001,ko02035,ko02044 Bacteria 3J11V@40117,COG0840@1,COG0840@2,COG2972@1,COG2972@2 NA|NA|NA T Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). MAG.T1.5_03788 330214.NIDE2654 0.0 1649.0 Nitrospirae cheA 2.7.13.3 ko:K02487,ko:K03407,ko:K06596 ko02020,ko02025,ko02030,map02020,map02025,map02030 M00506,M00507 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 Bacteria 3J0WW@40117,COG0643@1,COG0643@2,COG0745@1,COG0745@2,COG2198@1,COG2198@2 NA|NA|NA T Two component signalling adaptor domain MAG.T1.5_03790 330214.NIDE2652 1.1e-51 209.5 Bacteria cheW ko:K02659,ko:K03408,ko:K03415,ko:K11524 ko02020,ko02025,ko02030,map02020,map02025,map02030 M00506 ko00000,ko00001,ko00002,ko02022,ko02035,ko02044 Bacteria COG0835@1,COG0835@2 NA|NA|NA NT chemotaxis MAG.T1.5_03791 330214.NIDE2651 1.8e-100 373.2 Bacteria asgA ko:K02666,ko:K03497,ko:K19622 ko02020,map02020 ko00000,ko00001,ko02022,ko02035,ko02044,ko03000,ko03036,ko04812 3.A.15.2 Bacteria COG0784@1,COG0784@2,COG1196@1,COG1196@2 NA|NA|NA D nuclear chromosome segregation MAG.T1.5_03792 330214.NIDE2650 2e-100 372.5 Bacteria cnpD3 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 R03409 RC00002 ko00000,ko00001,ko01000 Bacteria COG2206@1,COG2206@2 NA|NA|NA T PFAM metal-dependent phosphohydrolase, HD sub domain MAG.T1.5_03793 330214.NIDE2649 1.1e-255 889.4 Bacteria Bacteria COG2206@1,COG2206@2 NA|NA|NA T PFAM metal-dependent phosphohydrolase, HD sub domain MAG.T1.5_03795 330214.NIDE2646 9.8e-112 410.2 Nitrospirae lpxD GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 Bacteria 3J0GQ@40117,COG1044@1,COG1044@2 NA|NA|NA M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell MAG.T1.5_03796 330214.NIDE2645 1.9e-32 145.2 Bacteria ko:K02078,ko:K05553 ko00253,ko01056,ko01130,map00253,map01056,map01130 M00778 R06635,R06637,R06641,R06643,R06644,R06645,R09258,R09259,R10960,R11516 RC00004,RC00039,RC02545,RC02728,RC02729,RC02931,RC02932,RC02947 ko00000,ko00001,ko00002,ko01004,ko01008 Bacteria COG0236@1,COG0236@2 NA|NA|NA IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis MAG.T1.5_03797 330214.NIDE2644 1.8e-218 765.0 Nitrospirae 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 3J0DH@40117,COG0304@1,COG0304@2 NA|NA|NA I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP MAG.T1.5_03798 330214.NIDE2643 3.8e-180 637.5 Nitrospirae lptG ko:K11720 ko02010,map02010 M00320 ko00000,ko00001,ko00002,ko02000 1.B.42.1 Bacteria 3J0QQ@40117,COG0795@1,COG0795@2 NA|NA|NA S Predicted permease YjgP/YjgQ family MAG.T1.5_03799 330214.NIDE2642 2e-185 655.2 Nitrospirae lptF ko:K07091,ko:K11720 ko02010,map02010 M00320 ko00000,ko00001,ko00002,ko02000 1.B.42.1 Bacteria 3J0S0@40117,COG0795@1,COG0795@2 NA|NA|NA S Predicted permease YjgP/YjgQ family MAG.T1.5_03800 330214.NIDE2641 2.4e-33 147.5 Nitrospirae cspA ko:K03704 ko00000,ko03000 Bacteria 3J0QZ@40117,COG1278@1,COG1278@2 NA|NA|NA K 'Cold-shock' DNA-binding domain MAG.T1.5_03801 269799.Gmet_1635 5e-26 126.3 Desulfuromonadales Bacteria 1NSRW@1224,2WTZ6@28221,42YBG@68525,43TDF@69541,COG0457@1,COG0457@2 NA|NA|NA S Tetratricopeptide repeat MAG.T1.5_03802 330214.NIDE2639 3.3e-146 524.6 Nitrospirae 1.1.1.26 ko:K00015 ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120 R00717,R01388 RC00031,RC00042 ko00000,ko00001,ko01000 Bacteria 3J13M@40117,COG1052@1,COG1052@2 NA|NA|NA CH D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain MAG.T1.5_03803 330214.NIDE2638 0.0 1620.1 Nitrospirae dld ko:K18930 ko00000 Bacteria 3J0ZS@40117,COG0247@1,COG0247@2,COG0277@1,COG0277@2 NA|NA|NA C FAD linked oxidases, C-terminal domain MAG.T1.5_03806 330214.NIDE2635 2.5e-175 621.3 Bacteria ko:K13572 ko00000,ko03051 Bacteria COG2378@1,COG2378@2 NA|NA|NA K regulation of single-species biofilm formation MAG.T1.5_03807 330214.NIDE1569 3.1e-171 608.2 Bacteria ko:K03309 ko00000 2.A.23 Bacteria COG1301@1,COG1301@2 NA|NA|NA C dicarboxylic acid transport MAG.T1.5_03808 330214.NIDE1570 2.8e-184 651.4 Bacteria 3.4.24.40 ko:K01406 ko01503,map01503 ko00000,ko00001,ko01000,ko01002 Bacteria COG3391@1,COG3391@2 NA|NA|NA CO amine dehydrogenase activity MAG.T1.5_03809 330214.NIDE2630 0.0 1111.7 Bacteria M1-852 3.4.21.107 ko:K01173,ko:K04771 ko01503,ko02020,ko04210,map01503,map02020,map04210 M00728 ko00000,ko00001,ko00002,ko01000,ko01002,ko03029,ko03110 Bacteria COG0265@1,COG0265@2 NA|NA|NA O serine-type endopeptidase activity MAG.T1.5_03810 765698.Mesci_3450 1.4e-108 399.4 Phyllobacteriaceae ydeK Bacteria 1MVHN@1224,2TRCU@28211,43IDT@69277,COG0697@1,COG0697@2 NA|NA|NA EG transporter MAG.T1.5_03811 1298858.AUEL01000009_gene4227 1.6e-111 409.5 Phyllobacteriaceae norG Bacteria 1MV6F@1224,2TQP9@28211,43I0Z@69277,COG1167@1,COG1167@2 NA|NA|NA K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs MAG.T1.5_03812 344747.PM8797T_28259 2.3e-268 932.2 Planctomycetes Bacteria 2IWV8@203682,COG1112@1,COG1112@2,COG2251@1,COG2251@2 NA|NA|NA L AAA domain MAG.T1.5_03814 330214.NIDE3570 3e-69 270.0 Nitrospirae 2.7.13.3 ko:K11527 ko00000,ko01000,ko01001,ko02022 Bacteria 3J10H@40117,COG2203@1,COG2203@2,COG3437@1,COG3437@2,COG4191@1,COG4191@2 NA|NA|NA T Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_03816 1123389.ATXJ01000028_gene897 2.8e-21 107.8 Deinococcus-Thermus ko:K07075 ko00000 Bacteria 1WKPG@1297,COG1669@1,COG1669@2 NA|NA|NA S Nucleotidyltransferase domain MAG.T1.5_03817 102125.Xen7305DRAFT_00001740 1.5e-12 78.6 Pleurocapsales Bacteria 1G9J5@1117,3VKQ2@52604,COG2361@1,COG2361@2 NA|NA|NA S Protein of unknown function DUF86 MAG.T1.5_03819 330214.NIDE2625 4.2e-275 953.4 Nitrospirae hsdM 2.1.1.72 ko:K03427 ko00000,ko01000,ko02048 Bacteria 3J15I@40117,COG0286@1,COG0286@2 NA|NA|NA V Product type e enzyme MAG.T1.5_03820 644968.DFW101_2950 1.6e-78 300.1 Desulfovibrionales hsdS 3.1.21.3 ko:K01153,ko:K01154 ko00000,ko01000,ko02048 Bacteria 1NBM4@1224,2MD23@213115,2WRMQ@28221,42VMJ@68525,COG0732@1,COG0732@2,COG1708@1,COG1708@2 NA|NA|NA L PFAM DNA polymerase beta domain protein region MAG.T1.5_03821 76114.ebA265 3.4e-58 232.6 Rhodocyclales Bacteria 1RD5U@1224,2CAZK@1,2KYQG@206389,2W27N@28216,3005R@2 NA|NA|NA MAG.T1.5_03823 497321.C664_07088 5.7e-135 487.3 Rhodocyclales ko:K07341 ko00000,ko02048 Bacteria 1MWKW@1224,2KXUN@206389,2VP78@28216,COG3654@1,COG3654@2,COG3943@1,COG3943@2 NA|NA|NA S Virulence protein RhuM family MAG.T1.5_03824 330214.NIDE2620 0.0 1395.9 Nitrospirae hsdR 3.1.21.3 ko:K01153 ko00000,ko01000,ko02048 Bacteria 3J18J@40117,COG4096@1,COG4096@2 NA|NA|NA L Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_03827 330214.NIDE3257 8.5e-25 119.0 Bacteria bfd GO:0003674,GO:0005488,GO:0048037,GO:0051536,GO:0051537,GO:0051540 ko:K02192 ko00000 Bacteria COG2906@1,COG2906@2 NA|NA|NA P 2 iron, 2 sulfur cluster binding MAG.T1.5_03828 330214.NIDE3258 1.5e-77 295.8 Nitrospirae wrbA GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114 1.6.5.2 ko:K03809 ko00130,ko01110,map00130,map01110 R02964,R03643,R03816 RC00819 ko00000,ko00001,ko01000 Bacteria 3J192@40117,COG0655@1,COG0655@2 NA|NA|NA S NADPH-dependent FMN reductase MAG.T1.5_03830 330214.NIDE3261 9.7e-70 269.6 Bacteria ko:K09005 ko00000 Bacteria COG1430@1,COG1430@2 NA|NA|NA S Uncharacterized ACR, COG1430 MAG.T1.5_03831 330214.NIDE3262 4.7e-213 747.3 Bacteria ko:K05802 ko00000,ko02000 1.A.23.1.1 Bacteria COG0664@1,COG0664@2,COG3264@1,COG3264@2 NA|NA|NA M cellular water homeostasis MAG.T1.5_03832 330214.NIDE3263 0.0 1385.9 Nitrospirae relA 2.7.6.5 ko:K00951 ko00230,map00230 R00429 RC00002,RC00078 ko00000,ko00001,ko01000 Bacteria 3J0CX@40117,COG0317@1,COG0317@2 NA|NA|NA KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance MAG.T1.5_03833 330214.NIDE3264 7.8e-281 972.6 Nitrospirae recJ ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 3J0PF@40117,COG0608@1,COG0608@2 NA|NA|NA L DHH family MAG.T1.5_03835 330214.NIDE3266 0.0 1139.0 Bacteria hppA 3.6.1.1 ko:K15987 ko00190,map00190 ko00000,ko00001,ko01000 3.A.10.1 Bacteria COG3808@1,COG3808@2 NA|NA|NA C hydrogen-translocating pyrophosphatase activity MAG.T1.5_03837 330214.NIDE3268 8.3e-216 756.1 Bacteria Bacteria COG3005@1,COG3005@2 NA|NA|NA C denitrification pathway MAG.T1.5_03838 330214.NIDE3269 3.7e-230 803.9 Bacteria Bacteria COG3005@1,COG3005@2 NA|NA|NA C denitrification pathway MAG.T1.5_03840 330214.NIDE3271 9.4e-147 526.2 Bacteria narJ GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016530,GO:0022607,GO:0034622,GO:0042126,GO:0042128,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0051131,GO:0065003,GO:0071704,GO:0071840,GO:0071941,GO:0140104,GO:2001057 ko:K00373,ko:K17052 ko02020,map02020 ko00000,ko00001,ko02000 5.A.3.8 iE2348C_1286.E2348C_1350,iECABU_c1320.ECABU_c15020,iECIAI1_1343.ECIAI1_1469,iECO103_1326.ECO103_1331,iECO111_1330.ECO111_1557,iECW_1372.ECW_m1594,iEKO11_1354.EKO11_2354,iLF82_1304.LF82_1462,iNRG857_1313.NRG857_06280,iSSON_1240.SSON_1659,iWFL_1372.ECW_m1594,ic_1306.c1687 Bacteria COG2180@1,COG2180@2 NA|NA|NA C chaperone-mediated protein complex assembly MAG.T1.5_03841 330214.NIDE3272 3.8e-232 810.4 Nitrospirae 2.7.11.1 ko:K08884 ko00000,ko01000,ko01001 Bacteria 3J19W@40117,COG3391@1,COG3391@2 NA|NA|NA S NHL repeat MAG.T1.5_03842 330214.NIDE3273 2.6e-27 127.9 Nitrospirae tatA ko:K03116 ko03060,ko03070,map03060,map03070 M00336 ko00000,ko00001,ko00002,ko02044 2.A.64 Bacteria 3J1A4@40117,COG1826@1,COG1826@2 NA|NA|NA U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system MAG.T1.5_03845 330214.NIDE3276 0.0 1169.8 Bacteria Bacteria COG1032@1,COG1032@2 NA|NA|NA C radical SAM domain protein MAG.T1.5_03846 330214.NIDE3278 2.5e-183 647.9 Bacteria narJ GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016530,GO:0022607,GO:0034622,GO:0042126,GO:0042128,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0051131,GO:0065003,GO:0071704,GO:0071840,GO:0071941,GO:0140104,GO:2001057 ko:K00373,ko:K17052 ko02020,map02020 ko00000,ko00001,ko02000 5.A.3.8 iE2348C_1286.E2348C_1350,iECABU_c1320.ECABU_c15020,iECIAI1_1343.ECIAI1_1469,iECO103_1326.ECO103_1331,iECO111_1330.ECO111_1557,iECW_1372.ECW_m1594,iEKO11_1354.EKO11_2354,iLF82_1304.LF82_1462,iNRG857_1313.NRG857_06280,iSSON_1240.SSON_1659,iWFL_1372.ECW_m1594,ic_1306.c1687 Bacteria COG2180@1,COG2180@2 NA|NA|NA C chaperone-mediated protein complex assembly MAG.T1.5_03847 330214.NIDE3279 1.5e-183 648.7 Bacteria Bacteria COG3381@1,COG3381@2 NA|NA|NA S protein complex oligomerization MAG.T1.5_03850 330214.NIDE3281 4.5e-199 700.3 Bacteria Bacteria 2AKTZ@1,31BM1@2 NA|NA|NA MAG.T1.5_03851 330214.NIDE3282 1.9e-94 352.8 Bacteria Bacteria COG2319@1,COG2319@2 NA|NA|NA S anaphase-promoting complex binding MAG.T1.5_03852 330214.NIDE3283 1.6e-218 765.4 Bacteria Bacteria COG2204@1,COG2204@2 NA|NA|NA T phosphorelay signal transduction system MAG.T1.5_03853 330214.NIDE3284 0.0 1885.5 Nitrospirae 2.7.13.3 ko:K02482,ko:K14986 ko02020,map02020 M00524 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 3J117@40117,COG3829@1,COG3829@2,COG4191@1,COG4191@2,COG5000@1,COG5000@2 NA|NA|NA T His Kinase A (phosphoacceptor) domain MAG.T1.5_03854 330214.NIDE3286 3.6e-147 527.7 Nitrospirae secF GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 ko:K03072,ko:K03074,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 Bacteria 3J0GM@40117,COG0341@1,COG0341@2 NA|NA|NA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA MAG.T1.5_03855 330214.NIDE3287 3.6e-291 1006.9 Nitrospirae secD GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 Bacteria 3J09Z@40117,COG0342@1,COG0342@2 NA|NA|NA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA MAG.T1.5_03856 330214.NIDE3288 3.7e-43 180.6 Nitrospirae yajC GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031522,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 Bacteria 3J0UB@40117,COG1862@1,COG1862@2 NA|NA|NA U Preprotein translocase subunit MAG.T1.5_03857 330214.NIDE3289 2.1e-208 731.5 Nitrospirae tgt GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0008479,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.29 ko:K00773 R03789,R10209 RC00063 ko00000,ko01000,ko03016 iECW_1372.ECW_m0475,iWFL_1372.ECW_m0475 Bacteria 3J0DU@40117,COG0343@1,COG0343@2 NA|NA|NA F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) MAG.T1.5_03858 330214.NIDE3290 2.3e-283 981.1 Nitrospirae argS GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 iAF987.Gmet_1434 Bacteria 3J0A8@40117,COG0018@1,COG0018@2 NA|NA|NA J Arginyl tRNA synthetase N terminal dom MAG.T1.5_03859 330214.NIDE3291 6.2e-87 327.8 Nitrospirae ko:K02843,ko:K02849 ko00540,ko01100,map00540,map01100 M00080 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 GT9 Bacteria 3J1E5@40117,COG0859@1,COG0859@2 NA|NA|NA M Glycosyltransferase family 9 (heptosyltransferase) MAG.T1.5_03860 330214.NIDE3292 5.1e-65 254.2 Nitrospirae mobA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.7.77 ko:K03752 ko00790,ko01100,map00790,map01100 R11581 ko00000,ko00001,ko01000 Bacteria 3J1C5@40117,COG0746@1,COG0746@2 NA|NA|NA H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor MAG.T1.5_03861 330214.NIDE3293 0.0 1190.6 Bacteria ko:K00405 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 ko00000,ko00001,ko00002 3.D.4.3 Bacteria COG2010@1,COG2010@2 NA|NA|NA C Cytochrome c MAG.T1.5_03862 330214.NIDE3294 5.4e-200 703.4 Bacteria Bacteria COG2010@1,COG2010@2 NA|NA|NA C Cytochrome c MAG.T1.5_03863 330214.NIDE3295 2.6e-239 834.3 Bacteria ccoP ko:K00405 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 ko00000,ko00001,ko00002 3.D.4.3 Bacteria COG2010@1,COG2010@2 NA|NA|NA C Cytochrome c MAG.T1.5_03864 330214.NIDE3296 0.0 1247.6 Bacteria 1.10.3.14 ko:K00425,ko:K08738 ko00190,ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00190,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00153,M00595 R10151,R11325 RC00061,RC03151,RC03152 ko00000,ko00001,ko00002,ko01000 3.D.4.3,3.D.4.6 Bacteria COG1271@1,COG1271@2 NA|NA|NA C aerobic electron transport chain MAG.T1.5_03868 330214.NIDE3299 5.3e-143 513.8 Nitrospirae 1.14.99.50 ko:K18912 ko00340,map00340 R11013 RC03323,RC03324 ko00000,ko00001,ko01000 Bacteria 3J14J@40117,COG1262@1,COG1262@2 NA|NA|NA S Evidence 4 Homologs of previously reported genes of MAG.T1.5_03869 330214.NIDE3300 3.9e-162 577.4 Nitrospirae Bacteria 3J14J@40117,COG1262@1,COG1262@2 NA|NA|NA S Evidence 4 Homologs of previously reported genes of MAG.T1.5_03871 518766.Rmar_2740 2.1e-11 76.3 Bacteroidetes Order II. Incertae sedis Bacteria 1FJBI@1100069,292MF@1,30IPY@2,4P6CM@976 NA|NA|NA S Protein of unknown function (DUF3047) MAG.T1.5_03872 330214.NIDE3303 0.0 1149.8 Bacteria 1.10.3.14 ko:K00425,ko:K08738 ko00190,ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00190,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00153,M00595 R10151,R11325 RC00061,RC03151,RC03152 ko00000,ko00001,ko00002,ko01000 3.D.4.3,3.D.4.6 Bacteria COG1271@1,COG1271@2 NA|NA|NA C aerobic electron transport chain MAG.T1.5_03874 330214.NIDE0413 2e-11 75.9 Bacteria bchB Bacteria 2DQ3Q@1,334KX@2 NA|NA|NA S Proto-chlorophyllide reductase 57 kd subunit MAG.T1.5_03875 330214.NIDE3306 8.5e-120 436.4 Bacteria ko:K08976 ko00000 Bacteria COG2322@1,COG2322@2 NA|NA|NA S membrane MAG.T1.5_03876 330214.NIDE3307 2.9e-163 581.3 Bacteria crtF GO:0003674,GO:0003824,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009058,GO:0009987,GO:0015994,GO:0015995,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0030493,GO:0030494,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0036067,GO:0036069,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.210,2.1.1.304,2.1.1.333 ko:K09846,ko:K13604,ko:K21460 ko00860,ko00906,ko01100,ko01110,map00860,map00906,map01100,map01110 R07521,R07524,R07527,R07529,R07533,R07535,R09063 RC00003,RC01662,RC02082 ko00000,ko00001,ko01000 Bacteria COG2813@1,COG2813@2 NA|NA|NA J rRNA (guanine-N2-)-methyltransferase activity MAG.T1.5_03877 330214.NIDE3308 1e-137 496.1 Bacteria Bacteria COG3794@1,COG3794@2 NA|NA|NA C PFAM blue (type 1) copper domain protein MAG.T1.5_03878 330214.NIDE3309 5.2e-89 335.1 Bacteria Bacteria COG1413@1,COG1413@2 NA|NA|NA C deoxyhypusine monooxygenase activity MAG.T1.5_03879 584708.Apau_0800 1.1e-08 67.0 Synergistetes ko:K03598 ko00000,ko03021 Bacteria 3TBN5@508458,COG3026@1,COG3026@2 NA|NA|NA T antisigma factor binding MAG.T1.5_03880 330214.NIDE3311 2.7e-153 548.1 Bacteria Bacteria COG3794@1,COG3794@2 NA|NA|NA C PFAM blue (type 1) copper domain protein MAG.T1.5_03881 330214.NIDE3313 0.0 3249.9 Bacteria 1.16.3.3,1.7.2.1 ko:K00368,ko:K07233,ko:K22349 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 Bacteria COG2132@1,COG2132@2 NA|NA|NA Q Multicopper oxidase MAG.T1.5_03882 330214.NIDE3314 0.0 1105.5 Bacteria Bacteria COG0531@1,COG0531@2 NA|NA|NA E amino acid MAG.T1.5_03883 330214.NIDE3315 2e-176 625.2 Bacteria Bacteria COG3291@1,COG3291@2 NA|NA|NA S metallopeptidase activity MAG.T1.5_03885 1353529.M899_3445 2.2e-25 123.2 Bacteria Bacteria 2EJ8D@1,33CZJ@2 NA|NA|NA MAG.T1.5_03886 330214.NIDE2891 8.3e-73 279.6 Nitrospirae 3.6.3.38 ko:K01990,ko:K09689,ko:K09691 ko02010,map02010 M00249,M00250,M00254 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.101,3.A.1.103 Bacteria 3J142@40117,COG1134@1,COG1134@2 NA|NA|NA GM Evidence 2b Function of strongly homologous gene MAG.T1.5_03888 330214.NIDE2890 7.1e-149 533.1 Nitrospirae rfbF 2.7.7.33 ko:K00978 ko00500,ko00520,ko01100,map00500,map00520,map01100 R00956 RC00002 ko00000,ko00001,ko01000 Bacteria 3J0K1@40117,COG1208@1,COG1208@2 NA|NA|NA JM Nucleotidyl transferase MAG.T1.5_03889 330214.NIDE2888 3.2e-198 697.6 Nitrospirae 4.1.1.35,4.2.1.46 ko:K01710,ko:K08678 ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00520,map00521,map00523,map00525,map01055,map01100,map01130 M00361,M00793 R01384,R06513 RC00402,RC00508 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0BW@40117,COG0451@1,COG0451@2 NA|NA|NA M 3-beta hydroxysteroid dehydrogenase/isomerase family MAG.T1.5_03890 330214.NIDE2887 4.1e-232 810.4 Nitrospirae 1.1.1.132,1.1.1.22 ko:K00012,ko:K00066 ko00040,ko00051,ko00053,ko00520,ko01100,ko02020,map00040,map00051,map00053,map00520,map01100,map02020 M00014,M00129,M00361,M00362 R00286,R00880 RC00291 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0EJ@40117,COG1004@1,COG1004@2 NA|NA|NA C Belongs to the UDP-glucose GDP-mannose dehydrogenase family MAG.T1.5_03891 330214.NIDE2886 4.4e-217 760.4 Nitrospirae Bacteria 3J176@40117,COG2227@1,COG2227@2 NA|NA|NA H Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_03892 330214.NIDE2885 3e-216 757.7 Bacteria Bacteria COG4310@1,COG4310@2 NA|NA|NA Q Domain of unknown function (DUF2172) MAG.T1.5_03893 330214.NIDE2884 3.6e-171 607.4 Bacteria Bacteria 28IYZ@1,2Z8WJ@2 NA|NA|NA MAG.T1.5_03894 330214.NIDE2883 9.9e-145 519.6 Bacteria 5.1.3.2 ko:K01784,ko:K20534 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000,ko01005,ko02000 4.D.2.1.9 GT2 Bacteria COG0451@1,COG0451@2 NA|NA|NA GM ADP-glyceromanno-heptose 6-epimerase activity MAG.T1.5_03896 330214.NIDE1618 1.8e-20 105.1 Bacteria Bacteria COG1621@1,COG1621@2 NA|NA|NA G Belongs to the glycosyl hydrolase 32 family MAG.T1.5_03897 330214.NIDE2880 3.2e-204 717.6 Bacteria Bacteria COG0438@1,COG0438@2 NA|NA|NA M transferase activity, transferring glycosyl groups MAG.T1.5_03898 330214.NIDE2879 1.6e-205 722.2 Bacteria Bacteria 2DM57@1,31S0Y@2 NA|NA|NA MAG.T1.5_03899 330214.NIDE2877 2.7e-133 481.5 Bacteria Bacteria 28JAC@1,2Z956@2 NA|NA|NA MAG.T1.5_03900 330214.NIDE2875 5.2e-190 670.2 Nitrospirae 5.1.3.10,5.1.3.2 ko:K01784,ko:K12454 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984,R04266 RC00289,RC00528 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0Z1@40117,COG0451@1,COG0451@2 NA|NA|NA M Male sterility protein MAG.T1.5_03901 330214.NIDE2874 6.2e-195 686.8 Bacteria Bacteria COG0438@1,COG0438@2 NA|NA|NA M transferase activity, transferring glycosyl groups MAG.T1.5_03902 330214.NIDE2873 4.3e-124 451.1 Bacteria wapR ko:K12987,ko:K12988 ko00000,ko01000,ko01003,ko01005 GT2 Bacteria COG1215@1,COG1215@2 NA|NA|NA M transferase activity, transferring glycosyl groups MAG.T1.5_03903 330214.NIDE2872 1.5e-153 549.3 Bacteria ko:K00754 ko00000,ko01000 GT4 Bacteria COG0438@1,COG0438@2 NA|NA|NA M transferase activity, transferring glycosyl groups MAG.T1.5_03904 330214.NIDE2871 0.0 1149.8 Bacteria nolO ko:K00612 ko00000,ko01000 Bacteria COG2192@1,COG2192@2 NA|NA|NA O nodulation MAG.T1.5_03905 330214.NIDE2870 8.7e-187 659.4 Nitrospirae rfbB 4.1.1.35,4.2.1.46 ko:K01710,ko:K08678 ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00520,map00521,map00523,map00525,map01055,map01100,map01130 M00361,M00793 R01384,R06513 RC00402,RC00508 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0BW@40117,COG0451@1,COG0451@2 NA|NA|NA M 3-beta hydroxysteroid dehydrogenase/isomerase family MAG.T1.5_03906 330214.NIDE2868 8.2e-284 982.6 Bacteria 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 R00578 RC00010 ko00000,ko00001,ko01000,ko01002 Bacteria COG0367@1,COG0367@2 NA|NA|NA E asparagine synthase MAG.T1.5_03907 330214.NIDE2867 1.2e-114 420.2 Bacteria Bacteria COG0438@1,COG0438@2 NA|NA|NA M transferase activity, transferring glycosyl groups MAG.T1.5_03908 448385.sce7019 4.2e-72 278.5 Proteobacteria Bacteria 1MVKH@1224,COG0726@1,COG0726@2 NA|NA|NA G polysaccharide deacetylase MAG.T1.5_03909 476272.RUMHYD_00091 5.4e-22 111.3 Clostridia Bacteria 1V1SM@1239,24K9P@186801,COG0110@1,COG0110@2 NA|NA|NA S Bacterial transferase hexapeptide (six repeats) MAG.T1.5_03910 330214.NIDE2866 1.3e-145 522.7 Bacteria Bacteria COG5653@1,COG5653@2 NA|NA|NA M Protein involved in cellulose biosynthesis MAG.T1.5_03911 330214.NIDE2865 5.1e-160 570.9 Bacteria Bacteria COG0399@1,COG0399@2 NA|NA|NA E UDP-4-amino-4-deoxy-L-arabinose aminotransferase MAG.T1.5_03912 330214.NIDE2864 4.7e-181 640.6 Nitrospirae gt2M Bacteria 3J15U@40117,COG1215@1,COG1215@2 NA|NA|NA M Glycosyltransferase like family 2 MAG.T1.5_03913 118161.KB235922_gene1041 5.7e-17 94.0 Cyanobacteria Bacteria 1G83J@1117,2DP8V@1,33122@2 NA|NA|NA MAG.T1.5_03914 330214.NIDE2862 7.4e-18 95.5 Bacteria Bacteria 2EGPU@1,33AFZ@2 NA|NA|NA MAG.T1.5_03915 330214.NIDE2861 1.3e-105 389.8 Nitrospirae Bacteria 3J1D4@40117,COG0726@1,COG0726@2 NA|NA|NA G Polysaccharide deacetylase MAG.T1.5_03916 330214.NIDE2860 4.6e-179 634.0 Nitrospirae Bacteria 3J15R@40117,COG3919@1,COG3919@2 NA|NA|NA T ATP-grasp domain MAG.T1.5_03917 330214.NIDE2859 8.9e-75 286.6 Bacteria wzb GO:0000271,GO:0003674,GO:0003824,GO:0004721,GO:0004725,GO:0005975,GO:0005976,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009242,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0033692,GO:0034637,GO:0034645,GO:0035335,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0046377,GO:0071704,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901576 3.1.3.48 ko:K01104 ko00000,ko01000 Bacteria COG0394@1,COG0394@2 NA|NA|NA T Belongs to the low molecular weight phosphotyrosine protein phosphatase family MAG.T1.5_03918 330214.NIDE2858 9.7e-127 459.5 Bacteria Bacteria COG0500@1,COG2226@2 NA|NA|NA Q methyltransferase MAG.T1.5_03919 330214.NIDE2856 9.3e-165 586.6 Bacteria Bacteria COG3307@1,COG3307@2 NA|NA|NA M -O-antigen MAG.T1.5_03920 330214.NIDE2854 2.2e-170 605.1 Nitrospirae Bacteria 3J15E@40117,COG0438@1,COG0438@2 NA|NA|NA M Glycosyl transferase 4-like domain MAG.T1.5_03921 330214.NIDE2853 3.8e-154 551.2 Bacteria sypH Bacteria COG0438@1,COG0438@2 NA|NA|NA M transferase activity, transferring glycosyl groups MAG.T1.5_03922 1318628.MARLIPOL_08334 8.4e-20 104.4 Gammaproteobacteria Bacteria 1QZXK@1224,1SHD6@1236,COG2242@1,COG2242@2 NA|NA|NA H Fkbm family MAG.T1.5_03923 330214.NIDE2852 8.2e-195 686.4 Nitrospirae Bacteria 3J157@40117,COG0438@1,COG0438@2 NA|NA|NA M Glycosyltransferase Family 4 MAG.T1.5_03925 330214.NIDE2831 1.6e-233 815.1 Nitrospirae capL ko:K02474 ko00520,map00520 R06894 RC00291 ko00000,ko00001,ko01000,ko01005 Bacteria 3J0HI@40117,COG0677@1,COG0677@2 NA|NA|NA C Belongs to the UDP-glucose GDP-mannose dehydrogenase family MAG.T1.5_03926 330214.NIDE2830 0.0 1252.3 Bacteria pulQ ko:K02453 ko03070,ko05111,map03070,map05111 M00331 ko00000,ko00001,ko00002,ko02044 3.A.15 Bacteria COG0457@1,COG0457@2,COG4796@1,COG4796@2 NA|NA|NA U Type ii and iii secretion system protein MAG.T1.5_03927 330214.NIDE2829 3.3e-86 324.3 Bacteria pulG ko:K02456 ko03070,ko05111,map03070,map05111 M00331 ko00000,ko00001,ko00002,ko02044 3.A.15 Bacteria COG2165@1,COG2165@2 NA|NA|NA NU general secretion pathway protein MAG.T1.5_03928 330214.NIDE2828 7.8e-62 243.0 Bacteria oxpG ko:K02456 ko03070,ko05111,map03070,map05111 M00331 ko00000,ko00001,ko00002,ko02044 3.A.15 Bacteria COG2165@1,COG2165@2 NA|NA|NA NU general secretion pathway protein MAG.T1.5_03929 330214.NIDE2827 4.1e-24 118.6 Bacteria Bacteria COG1388@1,COG1388@2,COG3170@1,COG3170@2 NA|NA|NA NU translation initiation factor activity MAG.T1.5_03930 330214.NIDE2826 1.6e-206 725.3 Nitrospirae pilC ko:K02455,ko:K02653 ko03070,ko05111,map03070,map05111 M00331 ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 Bacteria 3J0HZ@40117,COG1459@1,COG1459@2 NA|NA|NA U Type II secretion system (T2SS), protein F MAG.T1.5_03931 330214.NIDE2825 0.0 1078.5 Nitrospirae gspE ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 Bacteria 3J0XR@40117,COG2804@1,COG2804@2 NA|NA|NA NU Type II/IV secretion system protein MAG.T1.5_03932 330214.NIDE2824 6e-164 583.6 Bacteria ko:K02662 ko00000,ko02035,ko02044 Bacteria COG4972@1,COG4972@2 NA|NA|NA NU Pilus assembly protein MAG.T1.5_03933 330214.NIDE2823 1.3e-95 355.9 Bacteria pilN ko:K02461,ko:K02662,ko:K02663,ko:K12289 ko03070,ko05111,map03070,map05111 M00331 ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15 Bacteria COG3166@1,COG3166@2 NA|NA|NA NU PFAM Fimbrial assembly family protein MAG.T1.5_03936 330214.NIDE2820 5e-89 334.0 Bacteria tklG ko:K10927 ko05111,map05111 ko00000,ko00001,ko02044 Bacteria COG2165@1,COG2165@2 NA|NA|NA NU general secretion pathway protein MAG.T1.5_03937 330214.NIDE2819 4.7e-217 760.4 Nitrospirae proA GO:0003674,GO:0003824,GO:0004350,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 iLJ478.TM0293,iYO844.BSU13130 Bacteria 3J0ET@40117,COG0014@1,COG0014@2 NA|NA|NA E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate MAG.T1.5_03938 330214.NIDE2818 6.1e-252 876.7 Bacteria Bacteria 2F0JI@1,33TN8@2 NA|NA|NA MAG.T1.5_03939 330214.NIDE2817 2.9e-61 241.5 Nitrospirae lspG ko:K02456 ko03070,ko05111,map03070,map05111 M00331 ko00000,ko00001,ko00002,ko02044 3.A.15 Bacteria 3J14E@40117,COG4968@1,COG4968@2 NA|NA|NA U Type II secretion system (T2SS), protein G MAG.T1.5_03940 330214.NIDE2816 6.2e-168 597.0 Nitrospirae phcR ko:K19622 ko02020,map02020 ko00000,ko00001,ko02022 Bacteria 3J0NC@40117,COG1639@1,COG1639@2,COG2204@1,COG2204@2 NA|NA|NA T HDOD domain MAG.T1.5_03941 330214.NIDE2815 5.2e-187 660.6 Bacteria Bacteria COG3664@1,COG3664@2 NA|NA|NA G PFAM glycoside hydrolase family 39 MAG.T1.5_03944 330214.NIDE2898 3.4e-109 401.0 Nitrospirae ko:K01991,ko:K02237 ko02026,map02026 M00429 ko00000,ko00001,ko00002,ko02000,ko02044 1.B.18,3.A.11.1,3.A.11.2 Bacteria 3J17R@40117,COG1596@1,COG1596@2 NA|NA|NA M Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_03945 330214.NIDE2899 9.5e-108 396.4 Nitrospirae ko:K01991,ko:K02237 ko02026,map02026 M00429 ko00000,ko00001,ko00002,ko02000,ko02044 1.B.18,3.A.11.1,3.A.11.2 Bacteria 3J17R@40117,COG1596@1,COG1596@2 NA|NA|NA M Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_03946 330214.NIDE2901 1.8e-99 368.6 Bacteria Bacteria COG2197@1,COG2197@2 NA|NA|NA K response regulator MAG.T1.5_03947 330214.NIDE2902 5.9e-152 543.9 Bacteria aepY 4.1.1.82 ko:K09459 ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130 R04053 RC00506 ko00000,ko00001,ko01000 Bacteria COG0028@1,COG0028@2 NA|NA|NA EH Belongs to the TPP enzyme family MAG.T1.5_03948 330214.NIDE2903 6.5e-285 986.1 Bacteria pepM 2.7.7.74,5.4.2.9 ko:K01841,ko:K07281 ko00440,ko00562,ko01100,ko01120,ko01130,map00440,map00562,map01100,map01120,map01130 R00661,R09669 RC00002,RC02792 ko00000,ko00001,ko01000 Bacteria COG1213@1,COG1213@2,COG2513@1,COG2513@2 NA|NA|NA M nucleotidyl transferase MAG.T1.5_03950 330214.NIDE2906 1e-204 719.5 Nitrospirae glgA GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 GT5 Bacteria 3J0DJ@40117,COG0297@1,COG0297@2 NA|NA|NA G Synthesizes alpha-1,4-glucan chains using ADP-glucose MAG.T1.5_03952 330214.NIDE2908 1.7e-60 238.4 Nitrospirae ko:K03593 ko00000,ko03029,ko03036 Bacteria 3J1AV@40117,COG3536@1,COG3536@2 NA|NA|NA S Protein of unknown function (DUF971) MAG.T1.5_03953 330214.NIDE2909 2.9e-126 458.0 Nitrospirae recO GO:0008150,GO:0009314,GO:0009628,GO:0050896 2.6.99.2 ko:K03474,ko:K03584 ko00750,ko01100,ko03440,map00750,map01100,map03440 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000,ko03400 Bacteria 3J0S8@40117,COG1381@1,COG1381@2 NA|NA|NA L Involved in DNA repair and RecF pathway recombination MAG.T1.5_03954 330214.NIDE2910 1e-204 719.5 Bacteria mgtE ko:K06213 ko00000,ko02000 1.A.26.1 Bacteria COG2239@1,COG2239@2 NA|NA|NA P Acts as a magnesium transporter MAG.T1.5_03955 330214.NIDE2911 6.3e-149 533.5 Nitrospirae era GO:0000028,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006275,GO:0006996,GO:0008150,GO:0008156,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019219,GO:0019222,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0030174,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043021,GO:0043024,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045934,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051302,GO:0051781,GO:0060255,GO:0065003,GO:0065007,GO:0070181,GO:0070925,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:2000104,GO:2000112,GO:2000113 ko:K03595,ko:K06883 ko00000,ko03009,ko03029 Bacteria 3J0IB@40117,COG1159@1,COG1159@2 NA|NA|NA S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism MAG.T1.5_03956 330214.NIDE2912 2.2e-44 184.9 Bacteria ftsB GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0030428,GO:0032153,GO:0032505,GO:0042802,GO:0043093,GO:0044464,GO:0051301,GO:0071944 ko:K05589 ko00000,ko03036 Bacteria COG2919@1,COG2919@2 NA|NA|NA D cell cycle MAG.T1.5_03957 330214.NIDE2913 4.6e-233 813.5 Nitrospirae eno 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 Bacteria 3J0DB@40117,COG0148@1,COG0148@2 NA|NA|NA G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis MAG.T1.5_03958 330214.NIDE2915 1.7e-249 868.2 Nitrospirae gatB GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.12,6.3.5.6,6.3.5.7 ko:K01876,ko:K02434 ko00970,ko01100,map00970,map01100 M00359,M00360 R03905,R04212,R05577 RC00010,RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 Bacteria 3J0FK@40117,COG0064@1,COG0064@2 NA|NA|NA J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) MAG.T1.5_03959 330214.NIDE2916 9.3e-42 176.0 Nitrospirae XK27_07760 Bacteria 3J1B3@40117,COG4980@1,COG4980@2 NA|NA|NA S Evidence 4 Homologs of previously reported genes of MAG.T1.5_03960 330214.NIDE2917 5.5e-52 210.3 Bacteria WQ51_05790 Bacteria COG4768@1,COG4768@2 NA|NA|NA S Bacterial protein of unknown function (DUF948) MAG.T1.5_03961 330214.NIDE2918 1.1e-257 895.6 Nitrospirae gatA GO:0008150,GO:0040007 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 Bacteria 3J0AA@40117,COG0154@1,COG0154@2 NA|NA|NA J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) MAG.T1.5_03962 330214.NIDE2919 1.7e-60 238.4 Nitrospirae panD 4.1.1.11 ko:K01579 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R00489 RC00299 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0Q2@40117,COG0853@1,COG0853@2 NA|NA|NA H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine MAG.T1.5_03963 330214.NIDE2920 2.8e-37 161.0 Nitrospirae gatC 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 iAF987.Gmet_0076 Bacteria 3J0V3@40117,COG0721@1,COG0721@2 NA|NA|NA J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) MAG.T1.5_03964 330214.NIDE2921 0.0 1167.9 Nitrospirae glmS GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 iAF987.Gmet_1487 Bacteria 3J0CP@40117,COG0449@1,COG0449@2 NA|NA|NA M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source MAG.T1.5_03965 330214.NIDE2922 3.5e-246 857.4 Nitrospirae glmU GO:0000270,GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0005975,GO:0005976,GO:0006022,GO:0006023,GO:0006024,GO:0006629,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009252,GO:0009273,GO:0009987,GO:0016051,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0019134,GO:0022610,GO:0030203,GO:0030260,GO:0033692,GO:0034637,GO:0034645,GO:0035635,GO:0040007,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044650,GO:0046872,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0070569,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1903509 2.3.1.157,2.7.7.23 ko:K04042,ko:K11528,ko:K16203 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000,ko01002 3.A.1.5.2 iJN678.glmU,iLJ478.TM1629 Bacteria 3J0CG@40117,COG1207@1,COG1207@2 NA|NA|NA M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain MAG.T1.5_03966 330214.NIDE2923 1.4e-111 409.1 Nitrospirae Bacteria 3J0R2@40117,COG2928@1,COG2928@2 NA|NA|NA S Protein of unknown function (DUF502) MAG.T1.5_03967 330214.NIDE2924 1.2e-97 362.8 Nitrospirae tmk 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0NI@40117,COG0125@1,COG0125@2 NA|NA|NA F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis MAG.T1.5_03968 330214.NIDE2926 2.5e-165 588.2 Bacteria holB 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria COG2812@1,COG2812@2 NA|NA|NA L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity MAG.T1.5_03969 330214.NIDE2927 0.0 1089.7 Nitrospirae metG GO:0000049,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004825,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0017101,GO:0017102,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.10,6.1.1.20,6.1.1.6 ko:K01874,ko:K01890,ko:K04566,ko:K06878 ko00450,ko00970,map00450,map00970 M00359,M00360 R03658,R03659,R03660,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iEC042_1314.EC042_2346,iECUMN_1333.ECUMN_2446 Bacteria 3J0AI@40117,COG0073@1,COG0073@2,COG0143@1,COG0143@2 NA|NA|NA J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation MAG.T1.5_03970 330214.NIDE2928 1.9e-142 511.9 Bacteria Bacteria 2CHNQ@1,2Z7KM@2 NA|NA|NA MAG.T1.5_03971 1382356.JQMP01000004_gene670 1.3e-51 209.9 Thermomicrobia Bacteria 27Y06@189775,2G6BS@200795,COG1215@1,COG1215@2 NA|NA|NA M Glycosyltransferase like family 2 MAG.T1.5_03972 1282360.ABAC460_19840 1.8e-154 552.7 Proteobacteria Bacteria 1MWR0@1224,COG1032@1,COG1032@2 NA|NA|NA C SMART Elongator protein 3 MiaB NifB MAG.T1.5_03973 575540.Isop_1956 4.1e-15 90.1 Planctomycetes Bacteria 2IX04@203682,COG1807@1,COG1807@2 NA|NA|NA M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family MAG.T1.5_03974 330214.NIDE2929 0.0 1087.0 Nitrospirae ftsH 3.4.21.53 ko:K03798,ko:K04076,ko:K13525,ko:K17681 ko04141,ko05134,map04141,map05134 M00400,M00403,M00742 ko00000,ko00001,ko00002,ko01000,ko01002,ko03019,ko03029,ko03110,ko04131,ko04147 3.A.16.1 Bacteria 3J0AG@40117,COG0465@1,COG0465@2 NA|NA|NA D Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins MAG.T1.5_03975 330214.NIDE2930 4.3e-164 583.9 Nitrospirae czcD ko:K16264 ko00000,ko02000 2.A.4.1 Bacteria 3J11Z@40117,COG1230@1,COG1230@2 NA|NA|NA P Cation efflux family MAG.T1.5_03976 330214.NIDE2933 6.6e-168 596.7 Bacteria cobW Bacteria COG0523@1,COG0523@2 NA|NA|NA P cobalamin synthesis protein MAG.T1.5_03977 330214.NIDE2934 1e-99 369.4 Nitrospirae ybjG GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0042221,GO:0044464,GO:0046677,GO:0050380,GO:0050896,GO:0071944 3.6.1.27 ko:K06153,ko:K19302 ko00550,map00550 R05627 RC00002 ko00000,ko00001,ko01000,ko01011 iEC042_1314.EC042_0932 Bacteria 3J155@40117,COG0671@1,COG0671@2 NA|NA|NA I Acid phosphatase homologues MAG.T1.5_03978 330214.NIDE2937 2.5e-65 254.6 Bacteria Bacteria 2DNQI@1,32YKA@2 NA|NA|NA MAG.T1.5_03982 1532558.JL39_27625 2.3e-48 199.1 Rhizobiaceae 6.3.5.1 ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 Bacteria 1NMSE@1224,2VDME@28211,4BBRJ@82115,COG0388@1,COG0388@2 NA|NA|NA S Carbon-nitrogen hydrolase MAG.T1.5_03983 933262.AXAM01000083_gene773 3.2e-20 103.6 Desulfobacterales hicA GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016787,GO:0016788,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575 ko:K07339 ko00000,ko01000,ko02048 Bacteria 1NHPS@1224,2MP3Q@213118,2WSQY@28221,42XAS@68525,COG1724@1,COG1724@2 NA|NA|NA N HicA toxin of bacterial toxin-antitoxin, MAG.T1.5_03984 1379281.AVAG01000028_gene128 1.1e-27 128.6 Deltaproteobacteria Bacteria 1NPTZ@1224,2WWUI@28221,431E8@68525,COG1598@1,COG1598@2 NA|NA|NA S PFAM Uncharacterised protein family UPF0150 MAG.T1.5_03985 1278073.MYSTI_01650 1.4e-25 122.9 Myxococcales yafP 5.3.1.16 ko:K01814,ko:K03830,ko:K07146 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 Bacteria 1QX9F@1224,2WTE1@28221,2Z0P8@29,42XG7@68525,COG0454@1,COG0454@2 NA|NA|NA K Acetyltransferase (GNAT) domain MAG.T1.5_03986 1121382.JQKG01000001_gene2226 2.3e-60 239.2 Bacteria Bacteria COG0500@1,COG2226@2 NA|NA|NA Q methyltransferase MAG.T1.5_03987 91464.S7335_888 2.1e-66 259.2 Cyanobacteria Bacteria 1GET1@1117,2CFXT@1,2ZAIF@2 NA|NA|NA S Streptomycin adenylyltransferase MAG.T1.5_03988 756883.Halar_2532 1.3e-07 63.2 Archaea Archaea COG5378@1,arCOG02121@2157 NA|NA|NA S PFAM Nucleotide-binding protein, PIN domain MAG.T1.5_03990 1123242.JH636436_gene646 2e-60 238.4 Planctomycetes Bacteria 2J081@203682,COG0346@1,COG0346@2 NA|NA|NA E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily MAG.T1.5_03991 1232683.ADIMK_0861 6.2e-59 233.8 Alteromonadaceae adk 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1RCIS@1224,1S692@1236,467RY@72275,COG0563@1,COG0563@2 NA|NA|NA F COG0563 Adenylate kinase and related kinases MAG.T1.5_03992 234267.Acid_3700 4.3e-105 388.3 Bacteria Bacteria 28HDU@1,2Z7QC@2 NA|NA|NA S Protein of unknown function (DUF3626) MAG.T1.5_03994 330214.NIDE2938 3.7e-53 214.2 Bacteria Bacteria 290W2@1,2ZNHX@2 NA|NA|NA MAG.T1.5_03997 330214.NIDE2940 5.9e-178 630.9 Bacteria Bacteria COG1520@1,COG1520@2 NA|NA|NA S amino acid activation for nonribosomal peptide biosynthetic process MAG.T1.5_03998 330214.NIDE2941 7.1e-127 459.9 Bacteria ko:K09946 ko00000 Bacteria COG3422@1,COG3422@2 NA|NA|NA S double-strand break repair MAG.T1.5_03999 1565314.OA34_03655 4.6e-08 63.9 Epsilonproteobacteria Bacteria 1QTMF@1224,2B33V@1,2YQ90@29547,31VRH@2,42VGS@68525 NA|NA|NA S Antitoxin component of a toxin-antitoxin (TA) module MAG.T1.5_04000 1150621.SMUL_1243 5.3e-18 97.1 Bacteria ko:K06218 ko00000,ko02048 Bacteria COG2026@1,COG2026@2 NA|NA|NA DJ nuclease activity MAG.T1.5_04001 55601.VANGNB10_cII0523c 3.4e-33 148.3 Bacteria Bacteria 2EK6N@1,33DX1@2 NA|NA|NA MAG.T1.5_04003 479434.Sthe_2721 8.8e-64 250.0 Chloroflexi dcdA 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 Bacteria 2G7AC@200795,COG2131@1,COG2131@2 NA|NA|NA F MafB19-like deaminase MAG.T1.5_04005 330214.NIDE2953 0.0 1479.2 Bacteria 3.1.4.4 ko:K01115 ko00564,ko00565,ko01100,ko01110,ko04014,ko04024,ko04071,ko04072,ko04144,ko04666,ko04724,ko04912,ko05231,map00564,map00565,map01100,map01110,map04014,map04024,map04071,map04072,map04144,map04666,map04724,map04912,map05231 R01310,R02051,R07385 RC00017,RC00425 ko00000,ko00001,ko01000,ko04131 Bacteria COG1502@1,COG1502@2 NA|NA|NA I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol MAG.T1.5_04008 330214.NIDE1643 7.2e-83 313.2 Nitrospirae acs 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 3J0BJ@40117,COG0365@1,COG0365@2 NA|NA|NA I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA MAG.T1.5_04010 330214.NIDE1641 3.9e-103 380.9 Nitrospirae ribE GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.9,3.5.4.25,4.1.99.12 ko:K00793,ko:K02858,ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00066,R00425,R07281 RC00293,RC00958,RC00960,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS08950 Bacteria 3J0PR@40117,COG0307@1,COG0307@2 NA|NA|NA H Lumazine binding domain MAG.T1.5_04012 330214.NIDE1639 1.4e-201 708.8 Nitrospirae Bacteria 3J1DQ@40117,COG0477@1,COG2814@2 NA|NA|NA EGP MFS_1 like family MAG.T1.5_04013 595460.RRSWK_02441 2.3e-09 69.7 Planctomycetes Bacteria 2BYHG@1,2IZIW@203682,3208J@2 NA|NA|NA MAG.T1.5_04014 330214.NIDE1636 6.4e-214 750.0 Bacteria Bacteria COG4099@1,COG4099@2 NA|NA|NA F phospholipase Carboxylesterase MAG.T1.5_04015 330214.NIDE1635 5e-164 583.9 Nitrospirae ribD GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0016070,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 1.1.1.193,3.5.4.26 ko:K01498,ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1624,iLJ478.TM1828 Bacteria 3J0H2@40117,COG0117@1,COG0117@2,COG1985@1,COG1985@2 NA|NA|NA H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate MAG.T1.5_04016 330214.NIDE1634 0.0 1743.0 Nitrospirae ppdK 2.7.3.13,2.7.9.1 ko:K01006,ko:K22424 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 Bacteria 3J101@40117,COG0574@1,COG0574@2,COG1080@1,COG1080@2 NA|NA|NA G Belongs to the PEP-utilizing enzyme family MAG.T1.5_04018 330214.NIDE1632 0.0 1246.5 Nitrospirae glyS GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.14 ko:K01879,ko:K14164 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iAPECO1_1312.APECO1_2891,iE2348C_1286.E2348C_3810,iECABU_c1320.ECABU_c40010,iECED1_1282.ECED1_4242,iECH74115_1262.ECH74115_4934,iECNA114_1301.ECNA114_3710,iECOK1_1307.ECOK1_4005,iECP_1309.ECP_3661,iECS88_1305.ECS88_3976,iECSF_1327.ECSF_3393,iECSP_1301.ECSP_4554,iECs_1301.ECs4442,iG2583_1286.G2583_4300,iJN678.glyS,iUMN146_1321.UM146_17960,iUTI89_1310.UTI89_C4099,ic_1306.c4378 Bacteria 3J0F0@40117,COG0751@1,COG0751@2 NA|NA|NA J Glycyl-tRNA synthetase beta subunit MAG.T1.5_04019 330214.NIDE1631 4.5e-174 617.1 Nitrospirae glyQ GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016874,GO:0016875,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0140098,GO:0140101 6.1.1.14 ko:K01878,ko:K14164 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iAF1260.b3560,iAF987.Gmet_2942,iJO1366.b3560,iPC815.YPO4072,iY75_1357.Y75_RS19360 Bacteria 3J0F5@40117,COG0752@1,COG0752@2 NA|NA|NA J Glycyl-tRNA synthetase alpha subunit MAG.T1.5_04021 330214.NIDE1624 9.9e-71 272.7 Bacteria cymR ko:K13643 ko00000,ko03000 Bacteria COG1959@1,COG1959@2 NA|NA|NA K 2 iron, 2 sulfur cluster binding MAG.T1.5_04022 330214.NIDE1623 7.5e-165 586.6 Bacteria subI GO:0005575,GO:0005623,GO:0042597,GO:0044464 ko:K02048 ko00920,ko02010,map00920,map02010 M00185 ko00000,ko00001,ko00002,ko02000 3.A.1.6.1,3.A.1.6.3 iJN678.sbpA Bacteria COG1613@1,COG1613@2 NA|NA|NA P Sulfate ABC transporter periplasmic sulfate-binding protein MAG.T1.5_04023 330214.NIDE1622 3.8e-138 497.7 Bacteria cysT ko:K02018,ko:K02046 ko00920,ko02010,map00920,map02010 M00185,M00189 ko00000,ko00001,ko00002,ko02000 3.A.1.6.1,3.A.1.6.3,3.A.1.8 Bacteria COG0555@1,COG0555@2 NA|NA|NA P ATPase-coupled sulfate transmembrane transporter activity MAG.T1.5_04024 330214.NIDE1621 1.7e-129 468.8 Bacteria cysW GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02046,ko:K02047 ko00920,ko02010,map00920,map02010 M00185 ko00000,ko00001,ko00002,ko02000 3.A.1.6.1,3.A.1.6.3 iPC815.YPO3013 Bacteria COG4208@1,COG4208@2 NA|NA|NA P ATPase-coupled sulfate transmembrane transporter activity MAG.T1.5_04025 330214.NIDE1620 1.1e-187 662.5 Bacteria cysA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008144,GO:0008150,GO:0008272,GO:0008509,GO:0015075,GO:0015103,GO:0015116,GO:0015318,GO:0015399,GO:0015405,GO:0015419,GO:0015698,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043225,GO:0043492,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0072348,GO:0097159,GO:0097367,GO:0098656,GO:0098660,GO:0098661,GO:0099133,GO:1901265,GO:1901363,GO:1901682,GO:1902358 3.6.3.25,3.6.3.29 ko:K02017,ko:K02045,ko:K10112,ko:K16787 ko00920,ko02010,map00920,map02010 M00185,M00189,M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00582,M00602,M00605,M00606 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.1,3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35,3.A.1.6.1,3.A.1.6.3,3.A.1.8 iE2348C_1286.E2348C_2607,iSSON_1240.SSON_2511 Bacteria COG1118@1,COG1118@2 NA|NA|NA P Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system MAG.T1.5_04027 330214.NIDE1618 1.2e-183 649.0 Bacteria Bacteria COG1621@1,COG1621@2 NA|NA|NA G Belongs to the glycosyl hydrolase 32 family MAG.T1.5_04028 330214.NIDE1617 2.1e-224 784.6 Bacteria Bacteria COG0438@1,COG0438@2 NA|NA|NA M transferase activity, transferring glycosyl groups MAG.T1.5_04029 330214.NIDE1616 6.7e-249 866.3 Bacteria Bacteria 2DM57@1,31S0Y@2 NA|NA|NA MAG.T1.5_04030 330214.NIDE1600 4e-99 368.6 Bacteria Bacteria COG3209@1,COG3209@2 NA|NA|NA M self proteolysis MAG.T1.5_04031 330214.NIDE1599 1.1e-136 492.7 Nitrospirae fabI GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006950,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0033554,GO:0036094,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051716,GO:0055114,GO:0065003,GO:0070417,GO:0071704,GO:0071840,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.3.1.10,1.3.1.9 ko:K00208 ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212 M00083,M00572 R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 3J11E@40117,COG0623@1,COG0623@2 NA|NA|NA I Enoyl-(Acyl carrier protein) reductase MAG.T1.5_04034 330214.NIDE1596 5.6e-72 276.9 Nitrospirae bcp 1.11.1.15,2.7.7.42,2.7.7.89 ko:K00982,ko:K03564 ko00000,ko01000 Bacteria 3J13P@40117,COG1225@1,COG1225@2 NA|NA|NA O AhpC/TSA family MAG.T1.5_04035 330214.NIDE2087 6.8e-11 73.9 Bacteria Bacteria COG3063@1,COG3063@2 NA|NA|NA NU photosynthesis MAG.T1.5_04036 330214.NIDE1594 4.9e-36 156.8 Nitrospirae ko:K09804 ko00000 Bacteria 3J1DP@40117,COG2952@1,COG2952@2 NA|NA|NA S Protein of unknown function (DUF507) MAG.T1.5_04037 330214.NIDE1593 1.2e-37 162.2 Nitrospirae ko:K09804 ko00000 Bacteria 3J1ED@40117,COG2952@1,COG2952@2 NA|NA|NA S Protein of unknown function (DUF507) MAG.T1.5_04038 330214.NIDE1592 3.9e-61 240.7 Nitrospirae ko:K09143 ko00000 Bacteria 3J181@40117,COG2164@1,COG2164@2 NA|NA|NA S Cyclophilin-like MAG.T1.5_04039 330214.NIDE1591 5.7e-106 390.6 Nitrospirae ko:K07502 ko00000 Bacteria 3J137@40117,COG3359@1,COG3359@2 NA|NA|NA L RNase_H superfamily MAG.T1.5_04043 330214.NIDE1587 0.0 1601.6 Bacteria 3.1.3.3 ko:K02038,ko:K02282,ko:K07018,ko:K07315 ko02010,map02010 M00222 ko00000,ko00001,ko00002,ko01000,ko02000,ko02035,ko02044,ko03021 3.A.1.7 Bacteria COG0500@1,COG1073@1,COG1073@2,COG2197@1,COG2197@2,COG2226@2,COG5000@1,COG5000@2 NA|NA|NA Q methyltransferase MAG.T1.5_04044 330214.NIDE1586 4.5e-156 557.8 Bacteria 2.7.13.3 ko:K07708,ko:K07709 ko02020,map02020 M00497,M00499 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria COG2203@1,COG2203@2,COG4191@1,COG4191@2 NA|NA|NA T Gaf domain MAG.T1.5_04045 330214.NIDE1585 1.9e-248 864.8 Nitrospirae ko:K02481,ko:K07713,ko:K07714 ko02020,map02020 M00499,M00500 ko00000,ko00001,ko00002,ko02022 Bacteria 3J0C2@40117,COG2204@1,COG2204@2 NA|NA|NA T Bacterial regulatory protein, Fis family MAG.T1.5_04046 330214.NIDE1584 1.8e-180 638.6 Nitrospirae MA20_23615 ko:K07814 ko00000,ko02022 Bacteria 3J0ID@40117,COG3437@1,COG3437@2 NA|NA|NA T response regulator MAG.T1.5_04047 330214.NIDE1583 1.1e-239 835.9 Nitrospirae recN GO:0000724,GO:0000725,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009295,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0030312,GO:0031668,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071944,GO:0090304,GO:1901360 ko:K03631,ko:K13582 ko04112,map04112 ko00000,ko00001,ko03400 Bacteria 3J0HU@40117,COG0497@1,COG0497@2 NA|NA|NA L May be involved in recombinational repair of damaged DNA MAG.T1.5_04048 330214.NIDE1582 9.9e-58 229.2 Nitrospirae trxA ko:K03671,ko:K05838 ko04621,ko05418,map04621,map05418 ko00000,ko00001,ko03110 iIT341.HP0824 Bacteria 3J0P6@40117,COG3118@1,COG3118@2 NA|NA|NA O Thioredoxin-like domain MAG.T1.5_04050 330214.NIDE1580 0.0 1565.1 Nitrospirae lptD GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0008643,GO:0008645,GO:0009279,GO:0015267,GO:0015288,GO:0015749,GO:0015750,GO:0015751,GO:0015757,GO:0016020,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0030312,GO:0030313,GO:0031975,GO:0034219,GO:0044462,GO:0044464,GO:0046323,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:1904659 ko:K04744,ko:K09774,ko:K22110 ko00000,ko02000 1.B.35.1,1.B.35.2,1.B.42.1 iAF987.Gmet_2474,iECO111_1330.ECO111_4695,iECSF_1327.ECSF_3725,iEcSMS35_1347.EcSMS35_4260 Bacteria 3J0QI@40117,COG1452@1,COG1452@2 NA|NA|NA M involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane MAG.T1.5_04051 330214.NIDE1579 9.9e-183 646.4 Nitrospirae folC GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.12,6.3.2.17 ko:K01932,ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2475,iJN746.PP_1997,iSDY_1059.SDY_2514 Bacteria 3J0I6@40117,COG0285@1,COG0285@2 NA|NA|NA H Mur ligase middle domain MAG.T1.5_04052 330214.NIDE1577 7.5e-152 543.1 Nitrospirae accD 2.1.3.15,6.4.1.2 ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 iJN678.accD Bacteria 3J0CK@40117,COG0777@1,COG0777@2 NA|NA|NA I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA MAG.T1.5_04053 330214.NIDE1576 1.7e-121 442.2 Nitrospirae 3.1.26.11,3.1.4.17 ko:K00784,ko:K01120 ko00230,ko03013,map00230,map03013 R00191,R01234 RC00296 ko00000,ko00001,ko01000,ko03016 Bacteria 3J14I@40117,COG1234@1,COG1234@2 NA|NA|NA S Beta-lactamase superfamily domain MAG.T1.5_04054 330214.NIDE1575 3.2e-95 354.8 Bacteria ureH Bacteria COG2215@1,COG2215@2 NA|NA|NA O Belongs to the NiCoT transporter (TC 2.A.52) family MAG.T1.5_04055 330214.NIDE1574 3.6e-191 674.1 Nitrospirae moaA GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0040007,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0071944,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.22,4.6.1.17 ko:K03639,ko:K20967 ko00790,ko01100,ko04122,map00790,map01100,map04122 R09394,R11372 RC03420,RC03425 ko00000,ko00001,ko01000 Bacteria 3J0PB@40117,COG2896@1,COG2896@2 NA|NA|NA H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate MAG.T1.5_04056 330214.NIDE1573 1.3e-73 282.3 Nitrospirae moaE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.8.1.12 ko:K03635 ko00790,ko01100,ko04122,map00790,map01100,map04122 R09395 RC02507 ko00000,ko00001,ko01000 iAPECO1_1312.APECO1_1305,iEC042_1314.EC042_0869,iEC55989_1330.EC55989_0828,iECABU_c1320.ECABU_c08270,iECED1_1282.ECED1_0750,iECIAI1_1343.ECIAI1_0820,iECIAI39_1322.ECIAI39_0761,iECNA114_1301.ECNA114_0717,iECO103_1326.ECO103_0820,iECO111_1330.ECO111_0846,iECO26_1355.ECO26_0911,iECOK1_1307.ECOK1_0787,iECP_1309.ECP_0799,iECS88_1305.ECS88_0802,iECSE_1348.ECSE_0839,iECSF_1327.ECSF_0711,iECW_1372.ECW_m0841,iEKO11_1354.EKO11_3101,iEcE24377_1341.EcE24377A_0848,iG2583_1286.G2583_1013,iLF82_1304.LF82_1369,iNRG857_1313.NRG857_03500,iSSON_1240.SSON_0764,iUMN146_1321.UM146_13720,iUTI89_1310.UTI89_C0785,iWFL_1372.ECW_m0841,ic_1306.c0867 Bacteria 3J1AN@40117,COG0314@1,COG0314@2 NA|NA|NA H MoaE protein MAG.T1.5_04057 330214.NIDE1572 1.1e-34 152.5 Bacteria moaD ko:K03636 ko04122,map04122 ko00000,ko00001 Bacteria COG1977@1,COG1977@2 NA|NA|NA H Mo-molybdopterin cofactor metabolic process MAG.T1.5_04058 330214.NIDE1571 1.2e-75 289.3 Nitrospirae moaC GO:0002682,GO:0002683,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009605,GO:0009607,GO:0009987,GO:0016043,GO:0016829,GO:0016849,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0022607,GO:0031347,GO:0031348,GO:0034214,GO:0035821,GO:0040007,GO:0042802,GO:0043170,GO:0043207,GO:0043545,GO:0043933,GO:0044003,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044413,GO:0044414,GO:0044419,GO:0045088,GO:0045824,GO:0046483,GO:0048519,GO:0048583,GO:0048585,GO:0050776,GO:0050777,GO:0050789,GO:0050896,GO:0051186,GO:0051188,GO:0051189,GO:0051259,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0051832,GO:0051833,GO:0052031,GO:0052037,GO:0052167,GO:0052170,GO:0052173,GO:0052200,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0061799,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0075136,GO:0080134,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 R11372 RC03425 ko00000,ko00001,ko01000 Bacteria 3J0PN@40117,COG0315@1,COG0315@2 NA|NA|NA H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) MAG.T1.5_04061 330214.NIDE1559 1.8e-102 379.4 Bacteria MA20_08550 ko:K15539 ko00000 Bacteria COG4395@1,COG4395@2 NA|NA|NA S Tim44 MAG.T1.5_04063 330214.NIDE2513 2.1e-27 127.9 Bacteria Bacteria 2DGSC@1,2ZX3U@2 NA|NA|NA MAG.T1.5_04065 330214.NIDE1554 5.1e-18 96.7 Bacteria Bacteria COG1598@1,COG1598@2 NA|NA|NA N PFAM Uncharacterised protein family UPF0150 MAG.T1.5_04068 1265505.ATUG01000001_gene3625 2.1e-78 298.9 Desulfobacterales Bacteria 1MU3A@1224,2MPTJ@213118,2WNPE@28221,42S73@68525,COG0745@1,COG0745@2 NA|NA|NA T Transcriptional regulatory protein, C terminal MAG.T1.5_04069 1121396.KB893080_gene898 3.1e-124 452.2 Desulfobacterales Bacteria 1QUJ7@1224,2MMQM@213118,2WU4G@28221,43BJF@68525,COG0642@1,COG2205@2 NA|NA|NA T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain MAG.T1.5_04070 330214.NIDE1387 7.1e-67 260.8 Bacteria GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016701,GO:0016702,GO:0042597,GO:0044464,GO:0050587,GO:0051213,GO:0055114 1.13.11.49 ko:K09162 ko00000,ko01000 Bacteria COG3253@1,COG3253@2 NA|NA|NA S peroxidase activity MAG.T1.5_04073 1057002.KB905370_gene3670 1.1e-123 450.7 Rhizobiaceae nolO ko:K00612 ko00000,ko01000 Bacteria 1MWBA@1224,2TV6G@28211,4BCY5@82115,COG2192@1,COG2192@2 NA|NA|NA O Carbamoyltransferase C-terminus MAG.T1.5_04074 1470591.BW41_03716 2.1e-28 133.3 Sphingomonadales Bacteria 1MWMZ@1224,2JZZ5@204457,2TVFK@28211,COG0726@1,COG0726@2 NA|NA|NA G polysaccharide deacetylase MAG.T1.5_04075 330214.NIDE0876 7e-94 350.1 Bacteria ko:K10936,ko:K16079 ko05111,map05111 ko00000,ko00001,ko02000 1.B.4.2.1 Bacteria COG3637@1,COG3637@2 NA|NA|NA M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety MAG.T1.5_04076 886379.AEWI01000012_gene1151 1.7e-09 71.6 Marinilabiliaceae Bacteria 28NIY@1,2FQNB@200643,2ZBK8@2,3XIYD@558415,4NM7G@976 NA|NA|NA MAG.T1.5_04077 1121456.ATVA01000019_gene1287 1.8e-151 542.7 Desulfovibrionales wbpD 2.3.1.201 ko:K13018 ko00520,map00520 R10100 RC00004,RC00166 ko00000,ko00001,ko01000,ko01005 Bacteria 1MZV9@1224,2MG42@213115,2WNXR@28221,42PR0@68525,COG0110@1,COG0110@2,COG0673@1,COG0673@2 NA|NA|NA S Hexapeptide repeat of succinyl-transferase MAG.T1.5_04078 330214.NIDE0878 1.9e-123 449.5 Bacteria ko:K03980 ko00000,ko01011,ko02000 2.A.66.4 Bacteria COG0728@1,COG0728@2 NA|NA|NA M peptidoglycan biosynthetic process MAG.T1.5_04079 314285.KT71_09902 1.1e-83 317.8 unclassified Gammaproteobacteria asnB 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 R00578 RC00010 ko00000,ko00001,ko01000,ko01002 Bacteria 1J58Y@118884,1MW4E@1224,1RQ7D@1236,COG0367@1,COG0367@2 NA|NA|NA F Asparagine synthase MAG.T1.5_04080 330214.NIDE0879 1.7e-117 429.5 Bacteria Bacteria COG2755@1,COG2755@2 NA|NA|NA E lipolytic protein G-D-S-L family MAG.T1.5_04081 330214.NIDE0880 2.8e-100 372.1 Bacteria Bacteria COG0438@1,COG0438@2 NA|NA|NA M transferase activity, transferring glycosyl groups MAG.T1.5_04083 330214.NIDE0883 5.1e-174 617.1 Bacteria exoA Bacteria COG1215@1,COG1215@2 NA|NA|NA M transferase activity, transferring glycosyl groups MAG.T1.5_04084 330214.NIDE0884 7e-141 506.5 Bacteria rhiI GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0009273,GO:0009987,GO:0016020,GO:0016043,GO:0016740,GO:0016741,GO:0022607,GO:0032259,GO:0042546,GO:0044085,GO:0044464,GO:0071554,GO:0071766,GO:0071770,GO:0071840,GO:0071944 ko:K15471 ko00000,ko01000,ko01008 Bacteria COG0500@1,COG2226@2 NA|NA|NA Q methyltransferase MAG.T1.5_04085 330214.NIDE0885 3.3e-222 777.3 Nitrospirae spsC 2.6.1.102 ko:K13010 ko00520,map00520 R10460 RC00006,RC00781 ko00000,ko00001,ko01000,ko01005,ko01007 Bacteria 3J09X@40117,COG0399@1,COG0399@2 NA|NA|NA E Belongs to the DegT DnrJ EryC1 family MAG.T1.5_04086 330214.NIDE0886 4.6e-103 380.6 Bacteria bplG Bacteria COG2148@1,COG2148@2 NA|NA|NA M undecaprenyl-phosphate glucose phosphotransferase activity MAG.T1.5_04087 330214.NIDE0887 3.7e-274 950.7 Bacteria capD GO:0008150,GO:0043900,GO:0043902,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0065007,GO:1900190,GO:1900192 4.2.1.115,4.2.1.135,4.2.1.46 ko:K01710,ko:K15894,ko:K15912,ko:K19421 ko00520,ko00521,ko00523,ko00525,ko01055,ko01130,map00520,map00521,map00523,map00525,map01055,map01130 M00793 R06513,R09697 RC00402,RC02609 ko00000,ko00001,ko00002,ko01000 Bacteria COG1086@1,COG1086@2 NA|NA|NA GM Polysaccharide biosynthesis protein MAG.T1.5_04089 330214.NIDE0888 1.8e-282 978.0 Bacteria wzi Bacteria COG3170@1,COG3170@2 NA|NA|NA NU translation initiation factor activity MAG.T1.5_04090 330214.NIDE0889 0.0 1369.8 Bacteria kpsD ko:K01991 ko02026,map02026 ko00000,ko00001,ko02000 1.B.18 Bacteria COG1596@1,COG1596@2 NA|NA|NA M polysaccharide export MAG.T1.5_04091 330214.NIDE0890 3.1e-162 578.2 Bacteria 3.1.21.3 ko:K01153,ko:K05789,ko:K07011,ko:K16554 ko05111,map05111 ko00000,ko00001,ko01000,ko01005,ko02000,ko02048 8.A.3.1 Bacteria COG3206@1,COG3206@2 NA|NA|NA M extracellular polysaccharide biosynthetic process MAG.T1.5_04092 330214.NIDE0891 7.4e-194 682.9 Nitrospirae hpnH Bacteria 3J0X6@40117,COG0535@1,COG0535@2 NA|NA|NA S Domain of unknown function (DUF3463) MAG.T1.5_04093 330214.NIDE0892 2.6e-54 218.0 Bacteria Bacteria 29E6W@1,3014W@2 NA|NA|NA MAG.T1.5_04095 330214.NIDE0895 4.8e-77 293.9 Bacteria Bacteria COG2010@1,COG2010@2 NA|NA|NA C Cytochrome c MAG.T1.5_04096 330214.NIDE0896 0.0 1104.4 Bacteria 1.10.3.14 ko:K00425,ko:K08738 ko00190,ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00190,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00153,M00595 R10151,R11325 RC00061,RC03151,RC03152 ko00000,ko00001,ko00002,ko01000 3.D.4.3,3.D.4.6 Bacteria COG1271@1,COG1271@2 NA|NA|NA C aerobic electron transport chain MAG.T1.5_04097 330214.NIDE0897 5.7e-141 506.9 Bacteria ko:K17052 ko00000,ko02000 5.A.3.8 Bacteria COG2010@1,COG2010@2 NA|NA|NA C Cytochrome c MAG.T1.5_04098 330214.NIDE0898 3.6e-163 580.9 Bacteria 1.3.5.1,1.3.5.4 ko:K00240,ko:K03886 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00151,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 Bacteria COG0723@1,COG0723@2 NA|NA|NA C oxidoreductase activity, acting on diphenols and related substances as donors MAG.T1.5_04099 330214.NIDE0899 2.3e-212 744.6 Nitrospirae ko:K00412,ko:K03887 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 ko00000,ko00001,ko00002,ko03029 Bacteria 3J0Q6@40117,COG1290@1,COG1290@2 NA|NA|NA C Cytochrome b/b6/petB MAG.T1.5_04101 330214.NIDE0901 0.0 1127.9 Bacteria 1.10.3.14 ko:K00425,ko:K08738 ko00190,ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00190,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00153,M00595 R10151,R11325 RC00061,RC03151,RC03152 ko00000,ko00001,ko00002,ko01000 3.D.4.3,3.D.4.6 Bacteria COG1271@1,COG1271@2 NA|NA|NA C aerobic electron transport chain MAG.T1.5_04102 330214.NIDE0902 3.3e-96 357.8 Bacteria soxD ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 Bacteria COG2010@1,COG2010@2 NA|NA|NA C Cytochrome c MAG.T1.5_04103 330214.NIDE0903 2.7e-129 468.0 Bacteria Bacteria COG2010@1,COG2010@2 NA|NA|NA C Cytochrome c MAG.T1.5_04104 330214.NIDE0904 6.1e-146 523.5 Bacteria Bacteria 2ERPD@1,33J8R@2 NA|NA|NA S Ethylbenzene dehydrogenase MAG.T1.5_04105 330214.NIDE0905 3e-163 581.3 Bacteria ko:K02305,ko:K07152 ko00910,ko01120,map00910,map01120 M00529 R00294 RC02794 ko00000,ko00001,ko00002,ko03029 3.D.4.10 Bacteria COG2010@1,COG2010@2 NA|NA|NA C Cytochrome c MAG.T1.5_04106 330214.NIDE0906 1.4e-101 376.3 Nitrospirae ubiA GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008412,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663 2.5.1.39 ko:K03179 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R05000,R05615 RC00209,RC02895 ko00000,ko00001,ko00002,ko01000,ko01006 iZ_1308.Z5639 Bacteria 3J0TY@40117,COG0382@1,COG0382@2 NA|NA|NA H UbiA prenyltransferase family MAG.T1.5_04107 330214.NIDE0907 2.1e-210 738.8 Nitrospirae Bacteria 3J0QX@40117,COG4249@1,COG4249@2 NA|NA|NA S Evidence 5 No homology to any previously reported sequences MAG.T1.5_04108 1205680.CAKO01000006_gene3328 2e-09 70.5 Alphaproteobacteria Bacteria 1NHW6@1224,2UK9W@28211,COG2755@1,COG2755@2 NA|NA|NA E lipolytic protein G-D-S-L family MAG.T1.5_04110 1288494.EBAPG3_9990 6.7e-95 354.0 Nitrosomonadales ko:K07497 ko00000 Bacteria 1MVXQ@1224,2VHER@28216,372VZ@32003,COG2801@1,COG2801@2 NA|NA|NA L PFAM Integrase, catalytic MAG.T1.5_04112 330214.NIDE3547 5.2e-37 160.6 Nitrospirae Bacteria 3J133@40117,COG0582@1,COG0582@2 NA|NA|NA L Belongs to the 'phage' integrase family MAG.T1.5_04113 330214.NIDE0336 2.2e-27 128.3 Bacteria ko:K02806 ko02060,map02060 ko00000,ko00001,ko01000,ko02000 Bacteria COG3311@1,COG3311@2 NA|NA|NA K DNA excision MAG.T1.5_04114 330214.NIDE0337 2.1e-132 478.8 Bacteria nicK ko:K07467 ko00000 Bacteria COG2946@1,COG2946@2 NA|NA|NA L Replication initiation factor MAG.T1.5_04115 1149133.ppKF707_0650 3.9e-13 81.3 Pseudomonas aeruginosa group Bacteria 1N130@1224,1S98I@1236,1YGCT@136841,2CECF@1,32RZM@2 NA|NA|NA S pilin assembly protein MAG.T1.5_04116 478741.JAFS01000001_gene1547 3.6e-77 295.0 Bacteria Bacteria 2FBN7@1,343TB@2 NA|NA|NA MAG.T1.5_04118 644801.Psest_2710 1.1e-07 64.3 Pseudomonas stutzeri group rsbP 3.1.3.3 ko:K07315 ko00000,ko01000,ko03021 Bacteria 1R3UE@1224,1RRJX@1236,1Z1A0@136846,COG0745@1,COG0745@2,COG2208@1,COG2208@2 NA|NA|NA KT COG0784 FOG CheY-like receiver MAG.T1.5_04119 330214.NIDE4010 1.7e-22 112.5 Bacteria Bacteria COG0582@1,COG0582@2 NA|NA|NA L DNA integration MAG.T1.5_04120 330214.NIDE2245 3.4e-204 717.6 Bacteria Bacteria COG0348@1,COG0348@2 NA|NA|NA C 4 iron, 4 sulfur cluster binding MAG.T1.5_04122 1341679.P253_02805 2.9e-76 292.0 Moraxellaceae ko:K07497 ko00000 Bacteria 1MWNX@1224,1RW9F@1236,3NJTA@468,COG2801@1,COG2801@2 NA|NA|NA L Integrase core domain MAG.T1.5_04123 330214.NIDE2876 5.9e-149 533.9 Bacteria Bacteria COG2755@1,COG2755@2 NA|NA|NA E lipolytic protein G-D-S-L family MAG.T1.5_04125 330214.NIDE3537 5.4e-140 504.2 Nitrospirae ada GO:0001130,GO:0003674,GO:0003700,GO:0003824,GO:0003908,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006355,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016740,GO:0016741,GO:0018125,GO:0018193,GO:0018198,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044728,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0046872,GO:0046914,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070988,GO:0071704,GO:0080090,GO:0080111,GO:0090304,GO:0140110,GO:1901360,GO:1901564,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 2.1.1.63,3.2.2.21 ko:K00567,ko:K10778,ko:K13529,ko:K13530,ko:K15051 ko03410,map03410 ko00000,ko00001,ko01000,ko03000,ko03400 Bacteria 3J14M@40117,COG0350@1,COG0350@2,COG2169@1,COG2169@2 NA|NA|NA L helix_turn_helix, arabinose operon control protein MAG.T1.5_04126 330214.NIDE3536 8.3e-43 179.9 Bacteria Bacteria COG2204@1,COG2204@2 NA|NA|NA T phosphorelay signal transduction system MAG.T1.5_04129 330214.NIDE3533 8.8e-101 373.2 Bacteria yiiM GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009636,GO:0009987,GO:0019748,GO:0042221,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0098754 Bacteria COG2258@1,COG2258@2 NA|NA|NA C MOSC domain MAG.T1.5_04130 330214.NIDE3532 1.1e-120 439.5 Bacteria ko:K07140 ko00000 Bacteria COG3217@1,COG3217@2 NA|NA|NA S molybdenum ion binding MAG.T1.5_04131 330214.NIDE3531 2e-126 458.8 Nitrospirae cynR GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 ko:K11921 ko00000,ko03000 Bacteria 3J16P@40117,COG0583@1,COG0583@2 NA|NA|NA K Transcriptional regulator MAG.T1.5_04132 330214.NIDE3529 7.1e-199 699.9 Nitrospirae ko:K07799 ko02020,map02020 M00648 ko00000,ko00001,ko00002,ko02000 8.A.1 Bacteria 3J11U@40117,COG0845@1,COG0845@2 NA|NA|NA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family MAG.T1.5_04133 330214.NIDE3528 0.0 1758.4 Nitrospirae mdtB GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K03296,ko:K07788,ko:K07789 ko02020,map02020 M00648 ko00000,ko00001,ko00002,ko02000 2.A.6.2 Bacteria 3J0XV@40117,COG0841@1,COG0841@2 NA|NA|NA V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family MAG.T1.5_04134 330214.NIDE3527 0.0 1711.8 Nitrospirae mdtC GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006855,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015238,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015307,GO:0015318,GO:0015672,GO:0015893,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046618,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 ko:K03296,ko:K07788,ko:K07789 ko02020,map02020 M00648 ko00000,ko00001,ko00002,ko02000 2.A.6.2 Bacteria 3J0XV@40117,COG0841@1,COG0841@2 NA|NA|NA V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family MAG.T1.5_04135 330214.NIDE3526 4.2e-76 290.8 Bacteria ko:K03088 ko00000,ko03021 Bacteria COG1595@1,COG1595@2 NA|NA|NA K DNA-templated transcription, initiation MAG.T1.5_04136 330214.NIDE3525 7.7e-135 486.9 Bacteria ko:K07165 ko00000 Bacteria COG3712@1,COG3712@2 NA|NA|NA PT iron ion homeostasis MAG.T1.5_04137 330214.NIDE3524 0.0 1420.2 Bacteria Bacteria COG4772@1,COG4772@2 NA|NA|NA P TonB-dependent receptor MAG.T1.5_04138 330214.NIDE3523 1.3e-111 409.5 Bacteria Bacteria COG5266@1,COG5266@2 NA|NA|NA P PFAM Nickel transport complex, NikM subunit, transmembrane MAG.T1.5_04139 330214.NIDE3522 3.2e-107 394.8 Bacteria ko:K09939 ko00000 Bacteria COG3182@1,COG3182@2 NA|NA|NA E Iron-regulated membrane protein MAG.T1.5_04140 330214.NIDE3519 7.2e-28 130.2 Bacteria 1.16.3.3,1.7.2.1 ko:K00368,ko:K07233,ko:K22349 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 Bacteria COG2132@1,COG2132@2 NA|NA|NA Q Multicopper oxidase MAG.T1.5_04141 330214.NIDE3518 3.5e-95 354.8 Nitrospirae dsbA Bacteria 3J19Z@40117,COG1651@1,COG1651@2 NA|NA|NA O DSBA-like thioredoxin domain MAG.T1.5_04143 330214.NIDE3516 5e-173 614.0 Nitrospirae ackA 2.7.2.1 ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 Bacteria 3J12N@40117,COG0282@1,COG0282@2 NA|NA|NA F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction MAG.T1.5_04144 330214.NIDE3515 0.0 1539.6 Nitrospirae xfp 4.1.2.22,4.1.2.9 ko:K01621 ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120 R00761,R01621 RC00032,RC00226 ko00000,ko00001,ko01000 Bacteria 3J10J@40117,COG3957@1,COG3957@2 NA|NA|NA H D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase MAG.T1.5_04145 330214.NIDE3514 9e-95 353.2 Nitrospirae 3.1.3.18 ko:K01091,ko:K07025 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 R01334 RC00017 ko00000,ko00001,ko01000 Bacteria 3J11X@40117,COG0546@1,COG0546@2 NA|NA|NA S phosphoglycolate phosphatase activity MAG.T1.5_04146 330214.NIDE3513 2.3e-174 618.2 Bacteria Bacteria COG0667@1,COG0667@2 NA|NA|NA C Aldo Keto reductase MAG.T1.5_04147 1122604.JONR01000045_gene2483 4.6e-144 518.1 Proteobacteria Bacteria 1MXRI@1224,2DBEC@1,2Z8RY@2 NA|NA|NA S Domain of unknown function (DUF3943) MAG.T1.5_04148 330214.NIDE3764 2.5e-79 302.0 Bacteria Bacteria 28PNA@1,2ZCB3@2 NA|NA|NA S Transglycosylase SLT domain MAG.T1.5_04149 330214.NIDE3510 2.3e-65 255.8 Bacteria Bacteria 2DT3N@1,33IIR@2 NA|NA|NA MAG.T1.5_04156 330214.NIDE3254 5.2e-246 856.7 Bacteria Bacteria COG2204@1,COG2204@2 NA|NA|NA T phosphorelay signal transduction system MAG.T1.5_04160 330214.NIDE3252 4.9e-40 170.2 Bacteria sugE ko:K11741 ko00000,ko02000 2.A.7.1 Bacteria COG2076@1,COG2076@2 NA|NA|NA P Multidrug Resistance protein MAG.T1.5_04161 330214.NIDE3251 0.0 1570.4 Bacteria ko:K15726 ko00000,ko02000 2.A.6.1.2 Bacteria COG3696@1,COG3696@2 NA|NA|NA P silver ion transport MAG.T1.5_04162 330214.NIDE3250 1e-173 616.3 Nitrospirae cusB ko:K15727 ko00000,ko02000 8.A.1.2.1 Bacteria 3J15V@40117,COG0845@1,COG0845@2 NA|NA|NA M Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_04163 330214.NIDE3249 1e-204 719.5 Nitrospirae cusC ko:K15725 ko00000,ko02000 1.B.17.2.2 Bacteria 3J1F2@40117,COG1538@1,COG1538@2 NA|NA|NA MU Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_04165 330214.NIDE3247 4e-100 370.9 Bacteria ko:K02282 ko00000,ko02035,ko02044 Bacteria COG2197@1,COG2197@2 NA|NA|NA K response regulator MAG.T1.5_04166 330214.NIDE3246 1.2e-134 486.5 Bacteria 2.7.13.3 ko:K07683 ko02020,map02020 M00483 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria COG4585@1,COG4585@2 NA|NA|NA T Histidine kinase MAG.T1.5_04167 330214.NIDE3245 1.7e-241 841.6 Bacteria Bacteria COG2204@1,COG2204@2 NA|NA|NA T phosphorelay signal transduction system MAG.T1.5_04168 330214.NIDE3244 0.0 1085.1 Bacteria fleS 2.7.13.3 ko:K02668,ko:K07710,ko:K07711,ko:K10942 ko02020,ko02024,ko05111,map02020,map02024,map05111 M00500,M00501,M00502,M00515 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 Bacteria COG4191@1,COG4191@2,COG5278@1,COG5278@2 NA|NA|NA T phosphoserine phosphatase activity MAG.T1.5_04169 330214.NIDE3242 1.4e-135 489.2 Bacteria focA ko:K02598,ko:K06212,ko:K21993 ko00000,ko02000 1.A.16.1.1,1.A.16.1.3,1.A.16.2,1.A.16.3 Bacteria COG2116@1,COG2116@2 NA|NA|NA P formate transmembrane transporter activity MAG.T1.5_04170 330214.NIDE3241 4.9e-277 959.9 Nitrospirae emrY ko:K03446,ko:K07786 ko02020,map02020 M00701 ko00000,ko00001,ko00002,ko02000 2.A.1.3,2.A.1.3.36 Bacteria 3J0PC@40117,COG0477@1,COG2814@2 NA|NA|NA U Major Facilitator Superfamily MAG.T1.5_04171 330214.NIDE3240 5.2e-252 876.7 Nitrospirae Bacteria 3J0N2@40117,COG1538@1,COG1538@2 NA|NA|NA M Evidence 2b Function of strongly homologous gene MAG.T1.5_04172 330214.NIDE3239 3.3e-214 751.1 Nitrospirae ko:K03543 M00701 ko00000,ko00002,ko02000 8.A.1.1 Bacteria 3J0NN@40117,COG1566@1,COG1566@2 NA|NA|NA V HlyD membrane-fusion protein of T1SS MAG.T1.5_04173 330214.NIDE3238 6.8e-244 849.7 Nitrospirae fhlA ko:K02584,ko:K12266,ko:K15836,ko:K21009 ko02020,ko02025,ko05132,map02020,map02025,map05132 ko00000,ko00001,ko03000 Bacteria 3J1FR@40117,COG2203@1,COG2203@2,COG3829@1,COG3829@2 NA|NA|NA KT Evidence 2b Function of strongly homologous gene MAG.T1.5_04176 330214.NIDE2582 0.0 2195.6 Nitrospirae dnaE GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 3J0FE@40117,COG0587@1,COG0587@2 NA|NA|NA L DNA-directed DNA polymerase MAG.T1.5_04177 330214.NIDE2583 5.6e-175 620.2 Nitrospirae accA GO:0001676,GO:0003674,GO:0003824,GO:0003989,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009317,GO:0009329,GO:0009987,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0019752,GO:0032787,GO:0032991,GO:0042759,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576,GO:1902494,GO:1990234 2.1.3.15,6.4.1.2 ko:K01962,ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 iAF1260.b0185,iBWG_1329.BWG_0177,iEC55989_1330.EC55989_0179,iECDH10B_1368.ECDH10B_0165,iECDH1ME8569_1439.ECDH1ME8569_0178,iECED1_1282.ECED1_0191,iECH74115_1262.ECH74115_0195,iECIAI1_1343.ECIAI1_0185,iECNA114_1301.ECNA114_0175,iECO111_1330.ECO111_0186,iECO26_1355.ECO26_0187,iECP_1309.ECP_0193,iECSE_1348.ECSE_0184,iECSF_1327.ECSF_0200,iECSP_1301.ECSP_0184,iECW_1372.ECW_m0181,iECs_1301.ECs0187,iEKO11_1354.EKO11_3733,iEcDH1_1363.EcDH1_3418,iEcE24377_1341.EcE24377A_0189,iEcHS_1320.EcHS_A0187,iG2583_1286.G2583_0188,iJN678.accA,iJN746.PP_1607,iJO1366.b0185,iJR904.b0185,iLF82_1304.LF82_0008,iNRG857_1313.NRG857_00945,iSDY_1059.SDY_0201,iSFV_1184.SFV_0168,iSF_1195.SF0175,iSFxv_1172.SFxv_0185,iS_1188.S0178,iUMNK88_1353.UMNK88_190,iWFL_1372.ECW_m0181,iY75_1357.Y75_RS00935,iZ_1308.Z0197 Bacteria 3J0CN@40117,COG0825@1,COG0825@2 NA|NA|NA I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA MAG.T1.5_04178 330214.NIDE2584 1.2e-143 515.8 Bacteria Bacteria COG2067@1,COG2067@2 NA|NA|NA I long-chain fatty acid transporting porin activity MAG.T1.5_04181 330214.NIDE2587 0.0 1404.4 Bacteria hrpB 3.6.4.13 ko:K03579 ko00000,ko01000 Bacteria COG1643@1,COG1643@2 NA|NA|NA L helicase activity MAG.T1.5_04182 330214.NIDE2588 1.9e-71 275.4 Bacteria ko:K03567 ko02026,map02026 ko00000,ko00001,ko03000 Bacteria COG2716@1,COG2716@2 NA|NA|NA E regulation of RNA biosynthetic process MAG.T1.5_04183 330214.NIDE2589 5.2e-68 263.8 Nitrospirae def GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.88 ko:K01462 ko00000,ko01000 Bacteria 3J0RI@40117,COG0242@1,COG0242@2 NA|NA|NA J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions MAG.T1.5_04184 330214.NIDE2590 2.3e-27 128.6 Bacteria ko:K07126 ko00000 Bacteria COG0790@1,COG0790@2 NA|NA|NA S beta-lactamase activity MAG.T1.5_04185 330214.NIDE2591 7.6e-156 557.0 Bacteria hemY Bacteria COG1232@1,COG1232@2 NA|NA|NA H protoporphyrinogen oxidase activity MAG.T1.5_04186 330214.NIDE2593 3.5e-51 207.6 Bacteria Bacteria 2DCFZ@1,2ZDZV@2 NA|NA|NA MAG.T1.5_04187 330214.NIDE2595 6.8e-86 323.6 Bacteria rluE GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.20,5.4.99.22 ko:K06178,ko:K06181 ko00000,ko01000,ko03009 Bacteria COG1187@1,COG1187@2 NA|NA|NA J pseudouridine synthase activity MAG.T1.5_04190 330214.NIDE2599 1.5e-118 432.6 Bacteria bioH GO:0003674,GO:0003824,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016787,GO:0016788,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0052689,GO:0071704,GO:0072330,GO:0090499,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.11.1.10,2.1.1.197,3.1.1.85,3.3.2.9 ko:K00433,ko:K01253,ko:K02169,ko:K02170 ko00780,ko00980,ko01100,ko04976,ko05204,map00780,map00980,map01100,map04976,map05204 M00572 R07013,R07014,R07027,R07071,R07072,R07082,R09410,R09417,R09443,R09543,R09725 RC00003,RC00460,RC00461,RC01447,RC01728,RC01764,RC02528 ko00000,ko00001,ko00002,ko01000,ko01002 iBWG_1329.BWG_3103,iECBD_1354.ECBD_0333,iECDH10B_1368.ECDH10B_3587,iECDH1ME8569_1439.ECDH1ME8569_3291,iETEC_1333.ETEC_3662,iEcDH1_1363.EcDH1_0301,iJO1366.b3412,iY75_1357.Y75_RS20155 Bacteria COG0596@1,COG0596@2 NA|NA|NA S hydrolase activity, acting on ester bonds MAG.T1.5_04191 330214.NIDE2603 1.3e-118 432.6 Bacteria 1.6.5.2 ko:K03809 ko00130,ko01110,map00130,map01110 R02964,R03643,R03816 RC00819 ko00000,ko00001,ko01000 Bacteria COG0426@1,COG0426@2 NA|NA|NA C nitric oxide reductase activity MAG.T1.5_04195 330214.NIDE2619 1e-55 223.0 Bacteria Bacteria COG2453@1,COG2453@2 NA|NA|NA T phosphatase MAG.T1.5_04196 1303518.CCALI_00699 1.5e-107 396.4 Bacteria Bacteria COG4320@1,COG4320@2 NA|NA|NA S Uncharacterized protein conserved in bacteria (DUF2252) MAG.T1.5_04197 330214.NIDE2613 2.5e-216 758.1 Nitrospirae hflX GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 ko:K03665 ko00000,ko03009 Bacteria 3J0AE@40117,COG2262@1,COG2262@2 NA|NA|NA S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis MAG.T1.5_04198 330214.NIDE2614 1.7e-44 184.9 Bacteria ko:K06218,ko:K07334 ko00000,ko02048 Bacteria COG2026@1,COG2026@2 NA|NA|NA DJ nuclease activity MAG.T1.5_04199 330214.NIDE2615 8.8e-38 162.5 Bacteria ko:K18830 ko00000,ko02048,ko03000 Bacteria COG1396@1,COG1396@2 NA|NA|NA K sequence-specific DNA binding MAG.T1.5_04201 391587.KAOT1_15217 9.7e-43 180.6 Bacteria Bacteria 2DMPM@1,32SWT@2 NA|NA|NA MAG.T1.5_04202 330214.NIDE1273 2.6e-33 147.9 Bacteria ko:K02806 ko02060,map02060 ko00000,ko00001,ko01000,ko02000 Bacteria COG3311@1,COG3311@2 NA|NA|NA K DNA excision MAG.T1.5_04203 330214.NIDE1274 2.2e-196 691.4 Nitrospirae Bacteria 3J1FQ@40117,COG4974@1,COG4974@2 NA|NA|NA L Belongs to the 'phage' integrase family MAG.T1.5_04206 706587.Desti_2984 9.1e-22 111.7 Syntrophobacterales Bacteria 1N8HX@1224,2DN50@1,2MS7V@213462,2WS94@28221,32VJ4@2,42VGC@68525 NA|NA|NA S Domain of unknown function (DUF4340) MAG.T1.5_04207 330214.NIDE1277 1.5e-262 911.8 Bacteria gldG ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria COG3225@1,COG3225@2 NA|NA|NA MAG.T1.5_04208 330214.NIDE1278 7.9e-124 449.9 Bacteria yxlG ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria COG1277@1,COG1277@2 NA|NA|NA MAG.T1.5_04209 330214.NIDE1279 2.5e-159 568.2 Bacteria ccmA 3.6.3.7 ko:K01990,ko:K09697 ko02010,ko02020,map02010,map02020 M00253,M00254 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.115 Bacteria COG1131@1,COG1131@2 NA|NA|NA V ATPase activity MAG.T1.5_04212 330214.NIDE1284 8.1e-85 320.1 Bacteria rlpA ko:K03642 ko00000 Bacteria COG0797@1,COG0797@2 NA|NA|NA M peptidoglycan binding MAG.T1.5_04214 330214.NIDE1286 4e-113 414.5 Nitrospirae Bacteria 3J1E2@40117,COG1413@1,COG1413@2 NA|NA|NA C Evidence 4 Homologs of previously reported genes of MAG.T1.5_04215 330214.NIDE2705 1.5e-11 74.7 Bacteria ko:K07497 ko00000 Bacteria COG2801@1,COG2801@2 NA|NA|NA L transposition MAG.T1.5_04219 522772.Dacet_1459 2.8e-28 131.0 Deferribacteres lcrS ko:K07497 ko00000 Bacteria 2GGNA@200930,COG2963@1,COG2963@2 NA|NA|NA L PFAM transposase IS3 IS911 family protein MAG.T1.5_04220 330214.NIDE1288 1.2e-48 201.1 Bacteria Bacteria COG1413@1,COG1413@2 NA|NA|NA C deoxyhypusine monooxygenase activity MAG.T1.5_04221 330214.NIDE1289 0.0 1439.5 Nitrospirae glgP 2.4.1.1,2.4.1.8 ko:K00688,ko:K00691 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 R01555,R02111 RC00049 ko00000,ko00001,ko01000 GH65,GT35 Bacteria 3J0W1@40117,COG0058@1,COG0058@2 NA|NA|NA G Carbohydrate phosphorylase MAG.T1.5_04223 330214.NIDE1291 0.0 1257.3 Nitrospirae pcrA 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 3J0VX@40117,COG0210@1,COG0210@2 NA|NA|NA L UvrD-like helicase C-terminal domain MAG.T1.5_04228 330214.NIDE2456 1.3e-146 525.8 Nitrospirae nadK GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 R00104 RC00002,RC00078 ko00000,ko00001,ko01000 iEcSMS35_1347.EcSMS35_2767,iHN637.CLJU_RS05480,iLJ478.TM1733,iSB619.SA_RS04895 Bacteria 3J0HS@40117,COG0061@1,COG0061@2 NA|NA|NA H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP MAG.T1.5_04229 330214.NIDE2455 4.7e-236 823.5 Bacteria preT 1.18.1.2,1.19.1.1,1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K00528,ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R10159,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 Bacteria COG0493@1,COG0493@2 NA|NA|NA C 'glutamate synthase MAG.T1.5_04230 330214.NIDE2454 1e-257 895.6 Nitrospirae fumC 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0FU@40117,COG0114@1,COG0114@2 NA|NA|NA C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate MAG.T1.5_04231 330214.NIDE2453 1.3e-68 265.8 Nitrospirae hsp ko:K13993 ko04141,map04141 ko00000,ko00001,ko03110 Bacteria 3J0TV@40117,COG0071@1,COG0071@2 NA|NA|NA O Belongs to the small heat shock protein (HSP20) family MAG.T1.5_04233 330214.NIDE2451 1.4e-214 751.9 Bacteria gltA 2.3.3.1,2.3.3.5 ko:K01647,ko:K01659 ko00020,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351,R00931 RC00004,RC00067,RC00406,RC02827 br01601,ko00000,ko00001,ko00002,ko01000 iJN678.gltA Bacteria COG0372@1,COG0372@2 NA|NA|NA C Belongs to the citrate synthase family MAG.T1.5_04236 330214.NIDE2447 9.1e-51 206.1 Bacteria arsC 1.20.4.1 ko:K00537 ko00000,ko01000 Bacteria COG1393@1,COG1393@2 NA|NA|NA P arsenate reductase (glutaredoxin) activity MAG.T1.5_04238 330214.NIDE2445 2.3e-210 738.0 Bacteria rnd 3.1.13.5 ko:K03684 ko00000,ko01000,ko03016 Bacteria COG0349@1,COG0349@2 NA|NA|NA J Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides MAG.T1.5_04239 330214.NIDE2444 2.3e-88 331.6 Bacteria cbpA GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0097159,GO:1901363 ko:K05516,ko:K05801,ko:K18481 M00670 ko00000,ko00002,ko02000,ko03036,ko03110 3.A.1.27.4,3.A.1.27.5 Bacteria COG0484@1,COG0484@2 NA|NA|NA O heat shock protein binding MAG.T1.5_04240 330214.NIDE2443 5.3e-218 763.5 Bacteria CP_0904 Bacteria COG1055@1,COG1055@2 NA|NA|NA P arsenite transmembrane transporter activity MAG.T1.5_04241 330214.NIDE2442 3.2e-251 874.0 Nitrospirae me 1.1.1.38 ko:K00027 ko00620,ko01200,ko02020,map00620,map01200,map02020 R00214 RC00105 ko00000,ko00001,ko01000 Bacteria 3J0WV@40117,COG0281@1,COG0281@2 NA|NA|NA C Malic enzyme, NAD binding domain MAG.T1.5_04244 330214.NIDE0337 7.2e-95 353.2 Bacteria nicK ko:K07467 ko00000 Bacteria COG2946@1,COG2946@2 NA|NA|NA L Replication initiation factor MAG.T1.5_04245 330214.NIDE0336 6.9e-34 149.8 Bacteria ko:K02806 ko02060,map02060 ko00000,ko00001,ko01000,ko02000 Bacteria COG3311@1,COG3311@2 NA|NA|NA K DNA excision MAG.T1.5_04246 330214.NIDE3547 6.2e-90 337.8 Nitrospirae Bacteria 3J133@40117,COG0582@1,COG0582@2 NA|NA|NA L Belongs to the 'phage' integrase family MAG.T1.5_04250 330214.NIDE4013 8.7e-61 239.6 Bacteria Bacteria 2EQ22@1,33HNG@2 NA|NA|NA MAG.T1.5_04251 330214.NIDE4014 9.2e-201 706.1 Bacteria Bacteria 2EUIU@1,33N0V@2 NA|NA|NA MAG.T1.5_04252 330214.NIDE4016 0.0 1089.3 Bacteria glnS GO:0003674,GO:0003824,GO:0004812,GO:0004819,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006425,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iECIAI39_1322.ECIAI39_0637 Bacteria COG0008@1,COG0008@2 NA|NA|NA J glutamate-tRNA ligase activity MAG.T1.5_04254 330214.NIDE4018 1.5e-290 1005.0 Bacteria ko:K15738 ko00000,ko02000 3.A.1.120.6 Bacteria COG0488@1,COG0488@2 NA|NA|NA L (ABC) transporter MAG.T1.5_04257 386456.JQKN01000006_gene1241 3.3e-80 305.8 Euryarchaeota ko:K07126 ko00000 Archaea 2Y5SU@28890,COG1479@1,arCOG05223@2157 NA|NA|NA S Protein of unknown function DUF262 MAG.T1.5_04263 330214.NIDE1644 1.1e-208 732.6 Bacteria Bacteria COG0457@1,COG0457@2,COG4249@1,COG4249@2 NA|NA|NA S B-1 B cell differentiation MAG.T1.5_04265 330214.NIDE1646 2.6e-95 354.8 Bacteria Bacteria 2EUFJ@1,33MXU@2 NA|NA|NA MAG.T1.5_04266 330214.NIDE1647 5.9e-101 373.6 Nitrospirae lpoB GO:0000270,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0019899,GO:0030203,GO:0030234,GO:0030312,GO:0030313,GO:0031241,GO:0031975,GO:0034645,GO:0042546,GO:0043085,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044093,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044462,GO:0044464,GO:0050790,GO:0065007,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0098552,GO:0098772,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 ko:K07337,ko:K21008 ko02025,map02025 ko00000,ko00001 Bacteria 3J16N@40117,COG3417@1,COG3417@2 NA|NA|NA M Peptidoglycan-synthase activator LpoB MAG.T1.5_04267 330214.NIDE1648 1e-225 789.3 Nitrospirae ko:K09859 ko00000 Bacteria 3J14B@40117,COG3014@1,COG3014@2 NA|NA|NA S protein conserved in bacteria MAG.T1.5_04268 330214.NIDE1649 7.7e-160 570.1 Nitrospirae Bacteria 2AAUK@1,3107C@2,3J1E0@40117 NA|NA|NA S LPP20 lipoprotein MAG.T1.5_04270 330214.NIDE1651 5.3e-72 276.9 Bacteria vapC ko:K07064 ko00000 Bacteria COG1848@1,COG1848@2 NA|NA|NA G Toxic component of a toxin-antitoxin (TA) module. An RNase MAG.T1.5_04272 330214.NIDE1654 4.7e-100 371.3 Nitrospirae proC GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0017144,GO:0018130,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0055114,GO:0055129,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_0899,iIT341.HP1158,iSBO_1134.SBO_0282,ic_1306.c0493 Bacteria 3J0N8@40117,COG0345@1,COG0345@2 NA|NA|NA E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline MAG.T1.5_04273 330214.NIDE1655 1.4e-24 118.2 Bacteria Bacteria 28ZVQ@1,2ZMK7@2 NA|NA|NA MAG.T1.5_04274 330214.NIDE1657 1.5e-60 240.4 Bacteria Bacteria COG0582@1,COG0582@2 NA|NA|NA L DNA integration MAG.T1.5_04275 1267005.KB911257_gene868 6.5e-08 64.7 Hyphomicrobiaceae Bacteria 1NVSH@1224,2F3UN@1,2US2K@28211,33WKV@2,3N8GE@45401 NA|NA|NA MAG.T1.5_04279 330214.NIDE1307 1.9e-83 315.1 Nitrospirae rpsG GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0016020,GO:0016043,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 ko:K02992 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0HK@40117,COG0049@1,COG0049@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA MAG.T1.5_04280 330214.NIDE1306 5.4e-62 243.4 Nitrospirae rpsL GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02950 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0IU@40117,COG0048@1,COG0048@2 NA|NA|NA J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit MAG.T1.5_04281 330214.NIDE1304 0.0 2691.4 Nitrospirae rpoC GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03046,ko:K13797 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 Bacteria 3J0BT@40117,COG0086@1,COG0086@2 NA|NA|NA K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates MAG.T1.5_04282 330214.NIDE1303 0.0 2474.1 Nitrospirae rpoB GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03043,ko:K13797 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 Bacteria 3J0CW@40117,COG0085@1,COG0085@2 NA|NA|NA K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates MAG.T1.5_04283 330214.NIDE1302 1.6e-142 512.3 Nitrospirae rplJ GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0017148,GO:0019222,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 ko:K02864,ko:K02935 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0NQ@40117,COG0222@1,COG0222@2,COG0244@1,COG0244@2 NA|NA|NA J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation MAG.T1.5_04284 330214.NIDE1301 2.5e-116 424.9 Nitrospirae rplA GO:0000027,GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006417,GO:0006446,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0017148,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045947,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 ko:K02863 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0GB@40117,COG0081@1,COG0081@2 NA|NA|NA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release MAG.T1.5_04285 330214.NIDE1300 6.2e-70 270.0 Nitrospirae rplK GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010467,GO:0015934,GO:0015968,GO:0016043,GO:0019538,GO:0019843,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0032984,GO:0032991,GO:0033554,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0042594,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0051716,GO:0065003,GO:0070925,GO:0071496,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02867 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0K2@40117,COG0080@1,COG0080@2 NA|NA|NA J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors MAG.T1.5_04286 330214.NIDE1299 4.1e-95 354.0 Nitrospirae nusG GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0030312,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 ko:K02601 ko00000,ko03009,ko03021 Bacteria 3J0JA@40117,COG0250@1,COG0250@2 NA|NA|NA K Participates in transcription elongation, termination and antitermination MAG.T1.5_04287 330214.NIDE1298 1e-24 118.6 Bacteria secE GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K03073 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 Bacteria COG0690@1,COG0690@2 NA|NA|NA U P-P-bond-hydrolysis-driven protein transmembrane transporter activity MAG.T1.5_04289 243164.DET1472 1.9e-51 211.1 Dehalococcoidia 3.4.24.40 ko:K01406 ko01503,map01503 ko00000,ko00001,ko01000,ko01002 Bacteria 2G9X3@200795,34DP2@301297,COG3209@1,COG3209@2,COG3391@1,COG3391@2 NA|NA|NA M amine dehydrogenase activity MAG.T1.5_04291 467661.RKLH11_4066 1.7e-40 172.2 unclassified Rhodobacteraceae ko:K07497 ko00000 Bacteria 1RG0C@1224,2U7S5@28211,3ZHKU@58840,COG2801@1,COG2801@2 NA|NA|NA L COG2801 Transposase and inactivated derivatives MAG.T1.5_04292 330214.NIDE2830 8.5e-188 664.1 Bacteria pulQ ko:K02453 ko03070,ko05111,map03070,map05111 M00331 ko00000,ko00001,ko00002,ko02044 3.A.15 Bacteria COG0457@1,COG0457@2,COG4796@1,COG4796@2 NA|NA|NA U Type ii and iii secretion system protein MAG.T1.5_04293 330214.NIDE2828 3.8e-34 151.0 Bacteria oxpG ko:K02456 ko03070,ko05111,map03070,map05111 M00331 ko00000,ko00001,ko00002,ko02044 3.A.15 Bacteria COG2165@1,COG2165@2 NA|NA|NA NU general secretion pathway protein MAG.T1.5_04295 330214.NIDE2825 1e-187 663.3 Nitrospirae gspE ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 Bacteria 3J0XR@40117,COG2804@1,COG2804@2 NA|NA|NA NU Type II/IV secretion system protein MAG.T1.5_04296 330214.NIDE2824 3e-16 92.8 Bacteria ko:K02662 ko00000,ko02035,ko02044 Bacteria COG4972@1,COG4972@2 NA|NA|NA NU Pilus assembly protein MAG.T1.5_04297 330214.NIDE2823 8e-11 74.3 Bacteria pilN ko:K02461,ko:K02662,ko:K02663,ko:K12289 ko03070,ko05111,map03070,map05111 M00331 ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15 Bacteria COG3166@1,COG3166@2 NA|NA|NA NU PFAM Fimbrial assembly family protein MAG.T1.5_04300 1206557.I7KQR9_9CAUD 6.9e-30 137.1 Siphoviridae Viruses 4QB4E@10239,4QN5F@10699,4QR9J@28883,4QVFU@35237 NA|NA|NA MAG.T1.5_04302 642492.Clole_1479 2.1e-35 156.0 Clostridia Bacteria 1W6YJ@1239,24P7D@186801,COG3935@1,COG3935@2 NA|NA|NA L DnaD domain protein MAG.T1.5_04304 358220.C380_09765 9.7e-41 173.7 Proteobacteria 1.8.4.10,1.8.4.8 ko:K00390 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R02021 RC00007,RC02862 ko00000,ko00001,ko00002,ko01000 Bacteria 1N5BH@1224,COG0175@1,COG0175@2 NA|NA|NA EH sulfate reduction MAG.T1.5_04306 679189.HMPREF9019_0945 2.8e-15 88.2 Bacteria Bacteria 2EHJD@1,33BB9@2 NA|NA|NA MAG.T1.5_04308 240016.ABIZ01000001_gene3452 4.8e-08 65.1 Bacteria lgtD Bacteria COG1216@1,COG1216@2 NA|NA|NA V Glycosyl transferase, family 2 MAG.T1.5_04309 279303.Q6J7Z8_9CAUD 2.3e-09 69.3 Siphoviridae Viruses 4QCXA@10239,4QMAJ@10699,4QPBH@28883,4QUZI@35237 NA|NA|NA S transferase activity MAG.T1.5_04313 1166018.FAES_1848 1.2e-29 137.9 Cytophagia ko:K06909 ko00000 Bacteria 47UFU@768503,4NSQV@976,COG1783@1,COG1783@2 NA|NA|NA S Phage terminase large subunit MAG.T1.5_04315 331869.BAL199_00150 3.3e-11 75.5 unclassified Alphaproteobacteria ko:K07497 ko00000 Bacteria 1MVC8@1224,2TRX0@28211,4BPSP@82117,COG2801@1,COG2801@2 NA|NA|NA L COG2801 Transposase and inactivated derivatives MAG.T1.5_04316 1123251.ATWM01000023_gene1479 2.7e-63 248.8 Intrasporangiaceae ko:K07497 ko00000 Bacteria 2GKDY@201174,4FEXK@85021,COG2801@1,COG2801@2 NA|NA|NA L COG2801 Transposase and inactivated derivatives MAG.T1.5_04317 223184.AS25_00560 1.5e-41 175.3 Micrococcaceae ko:K07483 ko00000 Bacteria 1WA0T@1268,2IQ8F@201174,COG2963@1,COG2963@2 NA|NA|NA L Transposase MAG.T1.5_04319 443218.AS9A_4275 1.4e-174 619.0 Mycobacteriaceae Bacteria 235SA@1762,2GRH0@201174,COG1396@1,COG1396@2,COG2856@1,COG2856@2 NA|NA|NA E IrrE N-terminal-like domain MAG.T1.5_04320 1268303.RHODMAR_5043 6.4e-66 258.5 Actinobacteria Bacteria 2DBQ2@1,2IF6C@201174,2ZABR@2 NA|NA|NA MAG.T1.5_04321 675635.Psed_1259 1.1e-30 140.6 Actinobacteria Bacteria 2F7YZ@1,2IQG9@201174,340CR@2 NA|NA|NA MAG.T1.5_04322 675635.Psed_1260 8.7e-210 737.6 Pseudonocardiales Bacteria 2GM8Y@201174,4DY7S@85010,COG1204@1,COG1204@2 NA|NA|NA L helicase superfamily c-terminal domain MAG.T1.5_04324 330214.NIDE2955 0.0 1650.2 Bacteria Bacteria 2F5HV@1,33Y3B@2 NA|NA|NA S IgA Peptidase M64 MAG.T1.5_04328 330214.NIDE0337 4.8e-89 334.7 Bacteria nicK ko:K07467 ko00000 Bacteria COG2946@1,COG2946@2 NA|NA|NA L Replication initiation factor MAG.T1.5_04332 644107.SL1157_0777 1.4e-14 85.1 Alphaproteobacteria Bacteria 1RA63@1224,2UCMB@28211,COG1961@1,COG1961@2 NA|NA|NA L Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_04335 1217720.ALOX01000216_gene2744 1.4e-48 199.5 Alphaproteobacteria ko:K07497 ko00000 Bacteria 1MVXQ@1224,2U0FG@28211,COG2801@1,COG2801@2 NA|NA|NA L COG2801 Transposase and inactivated derivatives MAG.T1.5_04336 864069.MicloDRAFT_00000260 2.4e-150 538.5 Alphaproteobacteria Bacteria 1QPKD@1224,2TU1F@28211,COG3547@1,COG3547@2 NA|NA|NA L Transposase IS116/IS110/IS902 family MAG.T1.5_04337 1449126.JQKL01000060_gene1855 4.7e-18 96.7 unclassified Clostridiales ko:K07497 ko00000 Bacteria 1TU21@1239,249HN@186801,26CFS@186813,COG2801@1,COG2801@2 NA|NA|NA L DDE domain MAG.T1.5_04338 1121948.AUAC01000003_gene2873 1.8e-14 87.4 Hyphomonadaceae Bacteria 1N06S@1224,2TQVV@28211,43YR0@69657,COG0457@1,COG0457@2 NA|NA|NA S MTH538 TIR-like domain (DUF1863) MAG.T1.5_04339 94624.Bpet4636 5.6e-72 277.7 Betaproteobacteria ko:K07497 ko00000 Bacteria 1MVN5@1224,2VII1@28216,COG2801@1,COG2801@2 NA|NA|NA L similarity to GP 17427840 MAG.T1.5_04340 330214.NIDE0912 1.3e-36 158.7 Bacteria ko:K07483,ko:K07497 ko00000 Bacteria COG2963@1,COG2963@2 NA|NA|NA L transposase activity MAG.T1.5_04341 710686.Mycsm_06464 8.5e-10 70.5 Actinobacteria Bacteria 2BA2X@1,2H850@201174,323GP@2 NA|NA|NA MAG.T1.5_04342 1283300.ATXB01000001_gene827 1.6e-63 249.6 Methylococcales Bacteria 1MUA8@1224,1RN5K@1236,1XEMB@135618,COG1538@1,COG1538@2 NA|NA|NA MU PFAM Outer membrane efflux protein MAG.T1.5_04344 159087.Daro_2890 8.5e-99 367.9 Rhodocyclales vhtD 3.1.21.3,3.4.23.51 ko:K01153,ko:K03605,ko:K04656,ko:K08315 ko00000,ko01000,ko01002,ko02048 Bacteria 1NRP8@1224,2KVVC@206389,2VGZQ@28216,COG0642@1,COG0680@1,COG0680@2,COG0784@1,COG0784@2,COG2198@1,COG2198@2,COG2205@2,COG4942@1,COG4942@2 NA|NA|NA T PhoQ Sensor MAG.T1.5_04345 324057.Pjdr2_3165 3.5e-14 84.7 Paenibacillaceae Bacteria 1VCZ3@1239,270MA@186822,4I8WD@91061,COG1357@1,COG1357@2 NA|NA|NA S PFAM pentapeptide repeat protein MAG.T1.5_04346 1120953.AUBH01000006_gene2603 9e-11 74.7 Alteromonadaceae ndvB 2.4.1.12,3.2.1.58 ko:K00694,ko:K01210,ko:K03292 ko00500,ko01100,ko02026,map00500,map01100,map02026 R00308,R02889,R03115 RC00005,RC00467 ko00000,ko00001,ko01000,ko01003,ko02000 2.A.2,4.D.3.1.2,4.D.3.1.5,4.D.3.1.6 GT2 Bacteria 1MWJJ@1224,1SZ1N@1236,46A3H@72275,COG5309@1,COG5309@2 NA|NA|NA G Glycosyl hydrolases family 17 MAG.T1.5_04347 1054860.KB913030_gene308 1.6e-132 479.6 Actinobacteria Bacteria 2GNNF@201174,COG1680@1,COG1680@2 NA|NA|NA V Beta-lactamase MAG.T1.5_04348 1121271.AUCM01000015_gene2487 6e-52 211.1 Alphaproteobacteria Bacteria 1R680@1224,2U8ZE@28211,COG1595@1,COG1595@2 NA|NA|NA K Protein of unknown function (DUF3489) MAG.T1.5_04350 266809.PM03_15220 5.1e-15 86.7 Alphaproteobacteria Bacteria 1NAHD@1224,2E7GT@1,2UHC5@28211,331ZH@2 NA|NA|NA MAG.T1.5_04352 911045.PSE_1980 9.6e-62 243.4 Alphaproteobacteria 2.1.1.197 ko:K02169 ko00780,ko01100,map00780,map01100 M00572 R09543 RC00003,RC00460 ko00000,ko00001,ko00002,ko01000 Bacteria 1QWJU@1224,2TWZZ@28211,COG4106@1,COG4106@2 NA|NA|NA S Methyltransferase domain MAG.T1.5_04353 1123072.AUDH01000057_gene3392 2.1e-32 144.8 Rhodospirillales yhdJ 2.1.1.72 ko:K07319 ko00000,ko01000,ko02048 Bacteria 1MVH7@1224,2JXKD@204441,2TRNA@28211,COG0863@1,COG0863@2,COG1475@1,COG1475@2 NA|NA|NA KL DNA methylase MAG.T1.5_04354 330214.NIDE1462 3.5e-149 534.3 Nitrospirae Bacteria 3J15N@40117,COG4584@1,COG4584@2 NA|NA|NA L Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.5_04355 330214.NIDE1463 2.7e-135 488.0 Nitrospirae istB Bacteria 3J0QU@40117,COG1484@1,COG1484@2 NA|NA|NA L Evidence 2b Function of strongly homologous gene MAG.T1.5_04356 1479235.KK366039_gene1869 5.9e-40 170.6 Gammaproteobacteria ko:K07497 ko00000 Bacteria 1R6QN@1224,1S7GS@1236,COG2801@1,COG2801@2 NA|NA|NA L Integrase core domain MAG.T1.5_04358 243090.RB818 6.9e-114 417.5 Planctomycetes 2.7.7.49 ko:K00986 ko00000,ko01000 Bacteria 2IZGP@203682,COG3344@1,COG3344@2 NA|NA|NA L Reverse transcriptase (RNA-dependent DNA polymerase) MAG.T1.5_04359 1122132.AQYH01000019_gene312 3.9e-112 412.1 Rhizobiaceae MA20_09420 2.7.7.76 ko:K07141 ko00790,map00790 R11582 ko00000,ko00001,ko01000 Bacteria 1MW0X@1224,2TR5D@28211,4BAYS@82115,COG2068@1,COG2068@2 NA|NA|NA H MobA-like NTP transferase domain MAG.T1.5_04360 398580.Dshi_2351 1.4e-51 209.1 Alphaproteobacteria pucA ko:K07402 ko00000 Bacteria 1MXKU@1224,2TUF3@28211,COG1975@1,COG1975@2 NA|NA|NA O Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family MAG.T1.5_04361 311402.Avi_3042 1.1e-20 106.7 Rhizobiaceae Bacteria 1R3KU@1224,2E5FY@1,2UU0R@28211,32SM6@2,4BIJR@82115 NA|NA|NA S Domain of unknown function (DUF4365) MAG.T1.5_04362 1156935.QWE_18328 3.2e-97 362.1 Rhizobiaceae Bacteria 1RATC@1224,28NVF@1,2UGBR@28211,2ZBTI@2,4BHU5@82115 NA|NA|NA MAG.T1.5_04364 1150399.AQYK01000001_gene1196 5.1e-63 248.4 Microbacteriaceae 3.1.1.85 ko:K02170,ko:K06889 ko00780,ko01100,map00780,map01100 M00572 R09725 RC00460,RC00461 ko00000,ko00001,ko00002,ko01000 Bacteria 2GMK3@201174,4FM70@85023,COG1073@1,COG1073@2 NA|NA|NA S Alpha/beta hydrolase family MAG.T1.5_04369 1209984.BN978_07297 2.3e-40 173.3 Mycobacteriaceae Bacteria 23EFS@1762,2BD79@1,2HCEY@201174,326VD@2 NA|NA|NA MAG.T1.5_04370 1123237.Salmuc_04151 4.7e-14 83.2 Alphaproteobacteria yfgF GO:0000302,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008081,GO:0008150,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0016020,GO:0016021,GO:0016787,GO:0016788,GO:0031224,GO:0033554,GO:0034059,GO:0034599,GO:0034614,GO:0035690,GO:0036293,GO:0036294,GO:0042221,GO:0042493,GO:0042542,GO:0042578,GO:0043900,GO:0044425,GO:0044464,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070301,GO:0070482,GO:0070887,GO:0071111,GO:0071236,GO:0071453,GO:0071454,GO:0071944,GO:0097237,GO:1900190,GO:1901700,GO:1901701 Bacteria 1N299@1224,2TT4R@28211,COG2200@1,COG2200@2 NA|NA|NA T EAL domain MAG.T1.5_04373 40215.BBOS01000014_gene2342 4.5e-48 197.6 Moraxellaceae 3.1.21.3 ko:K01154 ko00000,ko01000,ko02048 Bacteria 1MXSQ@1224,1S320@1236,3NNQM@468,COG0732@1,COG0732@2 NA|NA|NA V Type I restriction modification DNA specificity domain MAG.T1.5_04374 1121035.AUCH01000015_gene2552 3.1e-134 484.6 Rhodocyclales hsdM 2.1.1.72 ko:K03427 ko00000,ko01000,ko02048 Bacteria 1MW3A@1224,2KVTF@206389,2VHBK@28216,COG0286@1,COG0286@2 NA|NA|NA V COG0286 Type I restriction-modification system methyltransferase subunit MAG.T1.5_04376 1096546.WYO_0760 2e-72 279.3 Alphaproteobacteria Bacteria 1QYPF@1224,2TZ4J@28211,COG0500@1,COG2226@2 NA|NA|NA Q Methyltransferase domain MAG.T1.5_04377 1463825.JNXC01000068_gene325 9.2e-92 343.6 Pseudonocardiales Bacteria 2GJW4@201174,4E0AD@85010,COG0823@1,COG0823@2,COG1506@1,COG1506@2 NA|NA|NA EU Dienelactone hydrolase family MAG.T1.5_04378 388401.RB2150_08008 5.2e-83 313.9 unclassified Rhodobacteraceae rkpK 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 Bacteria 1MW5U@1224,2TREV@28211,3ZGVA@58840,COG1004@1,COG1004@2 NA|NA|NA C Belongs to the UDP-glucose GDP-mannose dehydrogenase family MAG.T1.5_04379 1123229.AUBC01000010_gene3375 2.2e-66 258.8 Bradyrhizobiaceae MA20_28490 ko:K07005 ko00000 Bacteria 1MWQE@1224,2TR7J@28211,3JVXP@41294,COG3467@1,COG3467@2 NA|NA|NA S Pyridoxamine 5'-phosphate oxidase MAG.T1.5_04380 1223521.BBJX01000019_gene585 1.4e-26 125.2 Comamonadaceae Bacteria 1MU0F@1224,2VIE2@28216,4ACB3@80864,COG1593@1,COG1593@2 NA|NA|NA G PFAM TRAP C4-dicarboxylate transport system permease DctM subunit MAG.T1.5_04381 1223521.BBJX01000019_gene584 8.8e-09 65.9 Betaproteobacteria Bacteria 1MVQM@1224,2W0CQ@28216,COG3386@1,COG3386@2 NA|NA|NA G SMP-30/Gluconolaconase/LRE-like region MAG.T1.5_04382 1223521.BBJX01000019_gene584 1.9e-35 154.8 Betaproteobacteria Bacteria 1MVQM@1224,2W0CQ@28216,COG3386@1,COG3386@2 NA|NA|NA G SMP-30/Gluconolaconase/LRE-like region MAG.T1.5_04384 371731.Rsw2DRAFT_0261 2.2e-40 171.8 Rhodobacter Bacteria 1FCT4@1060,1PGM7@1224,2TTGY@28211,COG2334@1,COG2334@2 NA|NA|NA H Choline/ethanolamine kinase MAG.T1.5_04385 926549.KI421517_gene914 9.2e-54 216.1 Cytophagia Bacteria 47MM1@768503,4NFHF@976,COG2207@1,COG2207@2 NA|NA|NA K Transcriptional regulator, AraC family # 3380 queries scanned # Total time (seconds): 27.8069310188 # Rate: 121.55 q/s