# emapper version: emapper-hotfix-numpy-45-g001c4bf emapper DB: 2.0 # command: ./emapper.py -m diamond --seed_ortholog_evalue 0.00001 --data_dir /home/bayegy/Databases/emapper/data_dir2.0.1/ --cpu 30 --temp_dir /media/bayegy/disk2/bayegy/pipeline_demos/binning/share_mix/Bin_all/emapper//MAG.T1.121/_tmp -i /media/bayegy/disk2/bayegy/pipeline_demos/binning/share_mix/Bin_all/Bin_prokka//MAG.T1.121/MAG.T1.121.faa -o /media/bayegy/disk2/bayegy/pipeline_demos/binning/share_mix/Bin_all/emapper//MAG.T1.121/MAG.T1.121 --usemem --override # time: Sat Jun 6 04:58:17 2026 #query_name seed_eggNOG_ortholog seed_ortholog_evalue seed_ortholog_score best_tax_level Preferred_name GOs EC KEGG_ko KEGG_Pathway KEGG_Module KEGG_Reaction KEGG_rclass BRITE KEGG_TC CAZy BiGG_Reaction taxonomic scope eggNOG OGs best eggNOG OG COG Functional cat. eggNOG free text desc. MAG.T1.121_00001 479434.Sthe_0358 1.4e-28 133.7 Thermomicrobia Bacteria 27Z7F@189775,2E3IJ@1,2G7AM@200795,32YH0@2 NA|NA|NA S Predicted membrane protein (DUF2085) MAG.T1.121_00002 479434.Sthe_0660 1.2e-37 163.7 Thermomicrobia Bacteria 27YSP@189775,2EHA5@1,2G7H6@200795,33B21@2 NA|NA|NA S Nuclease-related domain MAG.T1.121_00003 479434.Sthe_0659 1.8e-54 219.9 Thermomicrobia holB 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 27Y5T@189775,2G6K3@200795,COG2812@1,COG2812@2 NA|NA|NA L DNA polymerase III, delta subunit MAG.T1.121_00004 316274.Haur_1076 1.9e-63 250.0 Chloroflexia yaaT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 Bacteria 2G6AJ@200795,3756F@32061,COG1774@1,COG1774@2 NA|NA|NA NU PFAM PSP1 domain protein MAG.T1.121_00006 479434.Sthe_2148 3.9e-139 501.9 Thermomicrobia recN GO:0000724,GO:0000725,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009295,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0030312,GO:0031668,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071944,GO:0090304,GO:1901360 ko:K03631,ko:K13582 ko04112,map04112 ko00000,ko00001,ko03400 Bacteria 27XPC@189775,2G5V1@200795,COG0497@1,COG0497@2 NA|NA|NA L May be involved in recombinational repair of damaged DNA MAG.T1.121_00007 479434.Sthe_2155 1.6e-24 118.6 Thermomicrobia ybaB ko:K09747 ko00000 Bacteria 27YNT@189775,2G77S@200795,COG0718@1,COG0718@2 NA|NA|NA L Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection MAG.T1.121_00008 479434.Sthe_1847 8.4e-104 383.6 Thermomicrobia pyrB GO:0003674,GO:0003824,GO:0004070,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 iZ_1308.Z5856 Bacteria 27XZF@189775,2G6GU@200795,COG0540@1,COG0540@2 NA|NA|NA F Belongs to the ATCase OTCase family MAG.T1.121_00009 644966.Tmar_0245 1e-50 207.2 Clostridia Bacteria 1TT3D@1239,24BV1@186801,COG0491@1,COG0491@2 NA|NA|NA S domain protein MAG.T1.121_00010 479434.Sthe_1728 3.6e-148 531.6 Thermomicrobia 1.3.3.15,1.3.3.4 ko:K00231 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03222,R04178 RC00885 ko00000,ko00001,ko00002,ko01000 Bacteria 27Y1I@189775,2G5VN@200795,COG1232@1,COG1232@2 NA|NA|NA H Flavin containing amine oxidoreductase MAG.T1.121_00011 525904.Tter_0081 3.7e-235 821.2 unclassified Bacteria hppA 3.6.1.1 ko:K15987 ko00190,map00190 ko00000,ko00001,ko01000 3.A.10.1 Bacteria 2NNK9@2323,COG3808@1,COG3808@2 NA|NA|NA C pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for MAG.T1.121_00012 1382356.JQMP01000003_gene2165 4.9e-91 341.3 Thermomicrobia secF GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 ko:K03072,ko:K03074,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 Bacteria 27Y1D@189775,2G696@200795,COG0341@1,COG0341@2 NA|NA|NA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA MAG.T1.121_00013 1382356.JQMP01000003_gene2166 3.9e-148 531.6 Thermomicrobia secD GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 6.3.2.2 ko:K01919,ko:K03072,ko:K12257 ko00270,ko00480,ko01100,ko02024,ko03060,ko03070,map00270,map00480,map01100,map02024,map03060,map03070 M00118,M00335 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 Bacteria 27XK4@189775,2G5K5@200795,COG0342@1,COG0342@2 NA|NA|NA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA MAG.T1.121_00014 479434.Sthe_1723 2.9e-47 195.3 Thermomicrobia nadD GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18,3.6.1.55 ko:K00969,ko:K03574 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 Bacteria 27Y96@189775,2G6MY@200795,COG1057@1,COG1057@2 NA|NA|NA F Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) MAG.T1.121_00015 479434.Sthe_0079 3.5e-37 162.2 Thermomicrobia 3.1.3.15 ko:K04486 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013 RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 27ZB2@189775,2G8ST@200795,COG1387@1,COG1387@2 NA|NA|NA E PHP domain MAG.T1.121_00017 479434.Sthe_1721 1.3e-284 985.7 Thermomicrobia gyrA GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 5.99.1.3 ko:K02469 ko00000,ko01000,ko03032,ko03400 Bacteria 27Y2U@189775,2G5Q2@200795,COG0188@1,COG0188@2 NA|NA|NA L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner MAG.T1.121_00018 1128421.JAGA01000001_gene2342 5.5e-69 268.1 Bacteria Bacteria COG4260@1,COG4260@2 NA|NA|NA N virion core protein, lumpy skin disease virus MAG.T1.121_00019 525904.Tter_1257 1e-45 190.3 unclassified Bacteria pspA GO:0003674,GO:0005488,GO:0005515,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006950,GO:0008150,GO:0008289,GO:0009266,GO:0009271,GO:0009408,GO:0009605,GO:0009607,GO:0009615,GO:0009628,GO:0009889,GO:0009898,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0019897,GO:0019898,GO:0031234,GO:0031323,GO:0031326,GO:0042802,GO:0043167,GO:0043168,GO:0043207,GO:0043433,GO:0044092,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0048519,GO:0050789,GO:0050794,GO:0050896,GO:0051090,GO:0051171,GO:0051252,GO:0051704,GO:0051707,GO:0060187,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0098552,GO:0098562,GO:0098586,GO:1903506,GO:2000112,GO:2001141 3.1.21.3,5.4.99.13 ko:K01153,ko:K03615,ko:K03969,ko:K11942,ko:K15842 ko05120,map05120 M00564 ko00000,ko00001,ko00002,ko01000,ko02048 Bacteria 2NR8F@2323,COG1842@1,COG1842@2 NA|NA|NA KT PspA/IM30 family MAG.T1.121_00020 926569.ANT_20600 5.8e-11 75.5 Chloroflexi Bacteria 2G9CR@200795,33AIT@2,arCOG05710@1 NA|NA|NA MAG.T1.121_00021 926550.CLDAP_09640 1.7e-37 162.5 Bacteria Bacteria COG1996@1,COG1996@2 NA|NA|NA K Psort location Cytoplasmic, score MAG.T1.121_00022 479434.Sthe_1714 8.9e-84 317.4 Thermomicrobia Bacteria 27XSF@189775,2G5N9@200795,COG0438@1,COG0438@2 NA|NA|NA M Glycosyl transferase 4-like domain MAG.T1.121_00023 1403313.AXBR01000026_gene5188 4.9e-52 210.7 Bacillus fabZ 3.5.1.108,4.2.1.59 ko:K02372,ko:K16363 ko00061,ko00540,ko00780,ko01100,ko01212,map00061,map00540,map00780,map01100,map01212 M00060,M00083,M00572 R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965,R07764,R10117,R10121 RC00166,RC00300,RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004,ko01005 Bacteria 1V6EX@1239,1ZFJ9@1386,4HGX1@91061,COG0764@1,COG0764@2 NA|NA|NA I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs MAG.T1.121_00024 479434.Sthe_1710 7.8e-140 503.8 Thermomicrobia purA GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 Bacteria 27XGV@189775,2G602@200795,COG0104@1,COG0104@2 NA|NA|NA F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP MAG.T1.121_00025 1128421.JAGA01000002_gene6 6.5e-11 73.6 unclassified Bacteria hspR GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 ko:K13640 ko00000,ko03000 Bacteria 2NPTR@2323,COG0789@1,COG0789@2 NA|NA|NA K Transcriptional regulator, MerR family MAG.T1.121_00026 479434.Sthe_1709 1.8e-94 352.8 Thermomicrobia ko:K03686,ko:K05516 ko00000,ko03029,ko03036,ko03110 Bacteria 27XSE@189775,2G657@200795,COG0484@1,COG0484@2 NA|NA|NA O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins MAG.T1.121_00027 926569.ANT_23560 7.1e-23 114.4 Chloroflexi Bacteria 2DM5T@1,2G78W@200795,31U0Y@2 NA|NA|NA S Domain of unknown function (DUF4126) MAG.T1.121_00028 479434.Sthe_1705 4.3e-75 287.7 Thermomicrobia lexA 3.4.21.88 ko:K01356 M00729 ko00000,ko00002,ko01000,ko01002,ko03400 Bacteria 27Y6E@189775,2G6NC@200795,COG1974@1,COG1974@2 NA|NA|NA K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair MAG.T1.121_00029 479434.Sthe_1703 5.4e-187 661.4 Thermomicrobia mutS2 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 ko:K07456 ko03430,map03430 ko00000,ko00001,ko03400 Bacteria 27XIK@189775,2G5R8@200795,COG1193@1,COG1193@2 NA|NA|NA L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity MAG.T1.121_00030 479434.Sthe_1702 0.0 1082.4 Thermomicrobia mfd ko:K03723 ko03420,map03420 ko00000,ko00001,ko01000,ko03400 Bacteria 27XUQ@189775,2G5UW@200795,COG1197@1,COG1197@2 NA|NA|NA L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site MAG.T1.121_00031 1452536.JARE01000050_gene1989 2e-28 132.5 Microbacteriaceae comEA ko:K02237 M00429 ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 Bacteria 2IQDC@201174,4FPAM@85023,COG1555@1,COG1555@2 NA|NA|NA L SLBB domain MAG.T1.121_00032 42256.RradSPS_1526 4e-20 106.3 Rubrobacteria ko:K02238 M00429 ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 Bacteria 2GJGR@201174,4CPP2@84995,COG0658@1,COG0658@2 NA|NA|NA S Competence protein MAG.T1.121_00034 479434.Sthe_1687 6e-92 344.4 Thermomicrobia 2.3.1.157,2.7.7.13,2.7.7.23,2.7.7.24,5.4.2.8 ko:K00973,ko:K04042,ko:K16881 ko00051,ko00520,ko00521,ko00523,ko00525,ko01100,ko01110,ko01130,map00051,map00520,map00521,map00523,map00525,map01100,map01110,map01130 M00114,M00362,M00793 R00416,R00885,R01818,R02328,R05332 RC00002,RC00004,RC00166,RC00408 ko00000,ko00001,ko00002,ko01000 Bacteria 27XSX@189775,2G5KH@200795,COG1208@1,COG1208@2 NA|NA|NA M Nucleotidyl transferase MAG.T1.121_00035 479434.Sthe_1688 9.6e-76 290.4 Thermomicrobia prmA ko:K02687 ko00000,ko01000,ko03009 Bacteria 27Y0Q@189775,2G69X@200795,COG2264@1,COG2264@2 NA|NA|NA J Met-10+ like-protein MAG.T1.121_00036 479434.Sthe_1690 2.9e-143 515.4 Chloroflexi Bacteria 2G5XW@200795,COG1625@1,COG1625@2 NA|NA|NA C Protein of unknown function (DUF512) MAG.T1.121_00037 479434.Sthe_1692 9.1e-84 317.0 Thermomicrobia 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 R01009 RC00005 ko00000,ko00001,ko01000,ko01003 GT2 Bacteria 27XT0@189775,2G6TA@200795,COG0463@1,COG0463@2 NA|NA|NA M Glycosyltransferase like family 2 MAG.T1.121_00038 765420.OSCT_2651 5.6e-72 278.9 Chloroflexia vanW Bacteria 2G67R@200795,375CP@32061,COG2720@1,COG2720@2 NA|NA|NA V PFAM VanW family protein MAG.T1.121_00039 1128421.JAGA01000002_gene1898 1.8e-14 85.9 unclassified Bacteria Bacteria 2NRHK@2323,COG1716@1,COG1716@2 NA|NA|NA T Inner membrane component of T3SS, cytoplasmic domain MAG.T1.121_00040 1382356.JQMP01000004_gene415 1.5e-27 130.2 Thermomicrobia Bacteria 27Y7S@189775,2G79K@200795,COG1716@1,COG1716@2 NA|NA|NA T Protein of unknown function (DUF2662) MAG.T1.121_00041 479434.Sthe_1685 2.1e-64 252.3 Thermomicrobia rpe GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 iIT341.HP1386,iLJ478.TM1718 Bacteria 27Y7N@189775,2G6EU@200795,COG0036@1,COG0036@2 NA|NA|NA G Belongs to the ribulose-phosphate 3-epimerase family MAG.T1.121_00043 309801.trd_0635 2.8e-85 322.0 Thermomicrobia ko:K07045 ko00000 Bacteria 27Y4A@189775,2G6CW@200795,COG2159@1,COG2159@2 NA|NA|NA S Amidohydrolase MAG.T1.121_00044 479434.Sthe_1680 3.8e-38 164.9 Thermomicrobia ruvA GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 ko:K03550 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 27YFW@189775,2G6V7@200795,COG0632@1,COG0632@2 NA|NA|NA L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB MAG.T1.121_00045 479434.Sthe_1676 2.1e-140 505.8 Thermomicrobia hisD GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23,1.1.1.308 ko:K00013,ko:K15509 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1599 Bacteria 27XKM@189775,2G5KP@200795,COG0141@1,COG0141@2 NA|NA|NA C Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine MAG.T1.121_00046 479434.Sthe_1670 1.3e-223 783.1 Thermomicrobia pheT GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iG2583_1286.G2583_2160,iPC815.YPO2428 Bacteria 27XEM@189775,2G5QR@200795,COG0072@1,COG0072@2,COG0073@1,COG0073@2 NA|NA|NA J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily MAG.T1.121_00047 1382356.JQMP01000004_gene402 9.5e-115 420.2 Thermomicrobia pheS GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 27XFG@189775,2G5T1@200795,COG0016@1,COG0016@2 NA|NA|NA J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily MAG.T1.121_00048 479434.Sthe_1667 4.4e-167 594.3 Thermomicrobia eno 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 Bacteria 27Y41@189775,2G5VB@200795,COG0148@1,COG0148@2 NA|NA|NA G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis MAG.T1.121_00049 479434.Sthe_1664 6.5e-149 534.3 Thermomicrobia gpmI GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030145,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0043937,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046537,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0050789,GO:0050793,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 iECSE_1348.ECSE_3895,iJN678.yibO,iJN746.PP_5056 Bacteria 27Y1N@189775,2G7GD@200795,COG0696@1,COG0696@2 NA|NA|NA F Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate MAG.T1.121_00050 479434.Sthe_1662 1.1e-139 503.1 Thermomicrobia icd 1.1.1.41 ko:K00030 ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010 R00709 RC00114 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 27XMV@189775,2GAQN@200795,COG0473@1,COG0473@2 NA|NA|NA C Isocitrate/isopropylmalate dehydrogenase MAG.T1.121_00051 309801.trd_1450 1e-56 227.6 Thermomicrobia soxB 1.5.3.1 ko:K00303 ko00260,ko01100,map00260,map01100 R00610 RC00060,RC00557 ko00000,ko00001,ko01000 Bacteria 27XXT@189775,2G6HT@200795,COG0665@1,COG0665@2 NA|NA|NA E FAD dependent oxidoreductase MAG.T1.121_00052 1382356.JQMP01000003_gene2353 2.2e-162 578.9 Thermomicrobia glcD GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0033554,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616 1.1.2.4,1.1.3.15 ko:K00102,ko:K00104 ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130 R00197,R00475 RC00042,RC00044 ko00000,ko00001,ko01000 iJN746.PP_3745,iLF82_1304.LF82_0831,iNRG857_1313.NRG857_14750 Bacteria 27XF8@189775,2G5TM@200795,COG0277@1,COG0277@2 NA|NA|NA C FAD linked oxidases, C-terminal domain MAG.T1.121_00053 324602.Caur_2133 5e-61 241.9 Chloroflexia glcE ko:K11472 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 R00475 RC00042 ko00000,ko00001 Bacteria 2G6FW@200795,376EU@32061,COG0277@1,COG0277@2 NA|NA|NA C PFAM FAD linked oxidase domain protein MAG.T1.121_00054 479434.Sthe_0987 3.4e-122 445.3 Thermomicrobia ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 R00475 RC00042 ko00000,ko00001 Bacteria 27XTC@189775,2G5V8@200795,COG0247@1,COG0247@2 NA|NA|NA C Cysteine-rich domain MAG.T1.121_00055 479434.Sthe_0992 7.6e-99 368.2 Thermomicrobia pdtaS GO:0000155,GO:0000160,GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005524,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0017076,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 2.7.13.3,4.2.1.75,4.6.1.1 ko:K00936,ko:K01719,ko:K01768,ko:K02584 ko00230,ko00860,ko01100,ko01110,ko01120,ko02020,ko02025,ko04113,ko04213,map00230,map00860,map01100,map01110,map01120,map02020,map02025,map04113,map04213 M00121,M00695,M00839 R00089,R00434,R03165 RC00295,RC01861 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko03000 Bacteria 27XHF@189775,2G67M@200795,COG2203@1,COG2203@2,COG3605@1,COG3605@2,COG3920@1,COG3920@2 NA|NA|NA T Histidine kinase MAG.T1.121_00056 479434.Sthe_1975 2.1e-55 223.8 Thermomicrobia 3.2.1.123,3.2.1.4 ko:K01179,ko:K05991 ko00500,ko01100,map00500,map01100 R06200,R11307,R11308 ko00000,ko00001,ko01000 GH5,GH9 Bacteria 27Y4J@189775,2GBH8@200795,COG2730@1,COG2730@2 NA|NA|NA G Belongs to the glycosyl hydrolase 5 (cellulase A) family MAG.T1.121_00057 479434.Sthe_1158 3.7e-55 222.6 Thermomicrobia ko:K02847 ko00540,ko01100,map00540,map01100 M00080 ko00000,ko00001,ko00002,ko01000,ko01005,ko02000 9.B.67.4,9.B.67.5 Bacteria 27Y8C@189775,2G79D@200795,COG3307@1,COG3307@2 NA|NA|NA M O-Antigen ligase MAG.T1.121_00058 479434.Sthe_1156 1.4e-41 177.6 Thermomicrobia Bacteria 27XXU@189775,2G6TE@200795,COG3307@1,COG3307@2 NA|NA|NA M O-Antigen ligase MAG.T1.121_00059 326427.Cagg_0140 6.7e-52 211.5 Chloroflexia mprF ko:K07027 ko00000,ko02000 4.D.2 Bacteria 2G6NX@200795,3765H@32061,COG0392@1,COG0392@2 NA|NA|NA S PFAM conserved MAG.T1.121_00060 479434.Sthe_1154 2.7e-48 199.5 Thermomicrobia Bacteria 27Y1R@189775,2G61I@200795,COG0438@1,COG0438@2 NA|NA|NA M Glycosyl transferase 4-like domain MAG.T1.121_00062 324602.Caur_3412 4.3e-106 391.3 Chloroflexia ko:K03924 ko00000,ko01000 Bacteria 2GACN@200795,375BZ@32061,COG0714@1,COG0714@2 NA|NA|NA S PFAM ATPase associated with various cellular activities, AAA_3 MAG.T1.121_00063 1382356.JQMP01000004_gene368 3.1e-152 545.0 Thermomicrobia serS GO:0000049,GO:0000166,GO:0000287,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004828,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006434,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009059,GO:0009069,GO:0009070,GO:0009987,GO:0010467,GO:0016020,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016597,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0040007,GO:0042802,GO:0042803,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046983,GO:0070905,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iAF987.Gmet_3528,iSDY_1059.SDY_2368 Bacteria 27Y3M@189775,2G5PD@200795,COG0172@1,COG0172@2 NA|NA|NA J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) MAG.T1.121_00064 479434.Sthe_1626 1.4e-61 242.7 Thermomicrobia MA20_20605 Bacteria 27Y84@189775,2G6RY@200795,COG1403@1,COG1403@2 NA|NA|NA L HNH endonuclease MAG.T1.121_00065 479434.Sthe_1621 0.0 1386.7 Thermomicrobia uvrA ko:K03701 ko03420,map03420 ko00000,ko00001,ko03400 Bacteria 27XGQ@189775,2G60U@200795,COG0178@1,COG0178@2 NA|NA|NA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate MAG.T1.121_00066 479434.Sthe_1612 0.0 1126.3 Thermomicrobia valS 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 27Y20@189775,2G5VS@200795,COG0525@1,COG0525@2 NA|NA|NA J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner MAG.T1.121_00067 194439.CT1853 3e-33 148.7 Chlorobi mpg GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.2.2.21 ko:K03652 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 1FDYR@1090,COG2094@1,COG2094@2 NA|NA|NA L Belongs to the DNA glycosylase MPG family MAG.T1.121_00068 479434.Sthe_1614 1.3e-145 523.5 Thermomicrobia mutL ko:K03572 ko03430,map03430 ko00000,ko00001,ko03400 Bacteria 27XXX@189775,2G5XU@200795,COG0323@1,COG0323@2 NA|NA|NA L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex MAG.T1.121_00069 1125973.JNLC01000004_gene3102 2.4e-58 232.6 Bradyrhizobiaceae ko:K02025,ko:K15771 ko02010,map02010 M00207,M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.2 Bacteria 1NAZ3@1224,2U2JJ@28211,3K41D@41294,COG1175@1,COG1175@2 NA|NA|NA G Binding-protein-dependent transport system inner membrane component MAG.T1.121_00070 521045.Kole_0165 2.9e-84 319.3 Thermotogae ko:K02027 M00207 ko00000,ko00002,ko02000 3.A.1.1 Bacteria 2GCR1@200918,COG1653@1,COG1653@2 NA|NA|NA G Extracellular solute-binding protein MAG.T1.121_00071 521045.Kole_0164 6.9e-63 247.7 Thermotogae ko:K02026 M00207 ko00000,ko00002,ko02000 3.A.1.1 Bacteria 2GD3Q@200918,COG0395@1,COG0395@2 NA|NA|NA P binding-protein-dependent transport systems inner membrane component MAG.T1.121_00072 1051632.TPY_0021 4e-67 261.5 Clostridia Bacteria 1UJNN@1239,25BVK@186801,COG1028@1,COG1028@2 NA|NA|NA IQ Enoyl-(Acyl carrier protein) reductase MAG.T1.121_00073 479434.Sthe_1615 3.1e-74 285.0 Thermomicrobia Bacteria 27Y3S@189775,2G6K0@200795,COG2197@1,COG2197@2 NA|NA|NA K Two component transcriptional regulator, LuxR family MAG.T1.121_00074 1382356.JQMP01000004_gene365 1.4e-60 240.0 Thermomicrobia Bacteria 27XWJ@189775,2G6GT@200795,COG0463@1,COG0463@2 NA|NA|NA M Glycosyltransferase like family 2 MAG.T1.121_00075 479434.Sthe_1657 2.5e-86 325.5 Thermomicrobia nfo GO:0000726,GO:0003674,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0008833,GO:0009987,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.21.2 ko:K01151 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 27XEG@189775,2G5XZ@200795,COG0648@1,COG0648@2 NA|NA|NA L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin MAG.T1.121_00076 314271.RB2654_11178 1.1e-16 93.2 Alphaproteobacteria Bacteria 1RHGW@1224,2UA4T@28211,COG4898@1,COG4898@2 NA|NA|NA S Protein conserved in bacteria MAG.T1.121_00077 479434.Sthe_1653 1.3e-180 639.4 Thermomicrobia 1.2.1.3,1.2.1.9 ko:K00128,ko:K00131 ko00010,ko00030,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130,map01200 M00135,M00308,M00633 R00264,R00631,R00710,R00904,R01058,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 Bacteria 27XK3@189775,2G5NY@200795,COG1012@1,COG1012@2 NA|NA|NA C Aldehyde dehydrogenase family MAG.T1.121_00078 479434.Sthe_1652 3.5e-50 204.5 Thermomicrobia nuoI GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3,1.6.99.3 ko:K00338,ko:K02573,ko:K03941 ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016 M00143,M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1,3.D.1.6 Bacteria 27YAZ@189775,2G6P8@200795,COG1143@1,COG1143@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient MAG.T1.121_00079 479434.Sthe_1651 6.1e-231 807.4 Thermomicrobia 1.17.1.10,1.17.1.9 ko:K00123,ko:K05299 ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200 M00377 R00134,R00519 RC02796 ko00000,ko00001,ko00002,ko01000 Bacteria 27XUA@189775,2GBH3@200795,COG3383@1,COG3383@2 NA|NA|NA C NADH-ubiquinone oxidoreductase-G iron-sulfur binding region MAG.T1.121_00080 309801.trd_1474 1.8e-156 559.3 Thermomicrobia gatB GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.12,6.3.5.6,6.3.5.7 ko:K01876,ko:K02434 ko00970,ko01100,map00970,map01100 M00359,M00360 R03905,R04212,R05577 RC00010,RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 Bacteria 27Y3E@189775,2G62Q@200795,COG0064@1,COG0064@2 NA|NA|NA J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) MAG.T1.121_00081 309801.trd_1476 2.6e-150 538.5 Thermomicrobia gdhA 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 27XVS@189775,2G5SR@200795,COG0334@1,COG0334@2 NA|NA|NA C Belongs to the Glu Leu Phe Val dehydrogenases family MAG.T1.121_00082 309801.trd_1478 3.3e-70 271.6 Thermomicrobia trkA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03499 ko00000,ko02000 2.A.38.1,2.A.38.4 Bacteria 27XTU@189775,2G6J8@200795,COG0569@1,COG0569@2 NA|NA|NA P TrkA-C domain MAG.T1.121_00083 525904.Tter_0807 2.6e-39 168.3 unclassified Bacteria ceoB ko:K03499,ko:K10716 ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6,2.A.38.1,2.A.38.4 Bacteria 2NPXT@2323,COG0569@1,COG0569@2 NA|NA|NA P TrkA-N domain MAG.T1.121_00084 479434.Sthe_1643 1e-25 123.2 Thermomicrobia usp1 Bacteria 27YGW@189775,2G7D7@200795,COG0589@1,COG0589@2 NA|NA|NA T Universal stress protein family MAG.T1.121_00085 309801.trd_1481 4.2e-42 178.3 Thermomicrobia Bacteria 27Y5S@189775,2G6GC@200795,COG0639@1,COG0639@2 NA|NA|NA T Calcineurin-like phosphoesterase superfamily domain MAG.T1.121_00086 479434.Sthe_1641 5.7e-190 671.0 Chloroflexi gidA GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 ko:K03495 R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 Bacteria 2G629@200795,COG0445@1,COG0445@2 NA|NA|NA D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 MAG.T1.121_00088 479434.Sthe_1489 2.4e-297 1028.1 Thermomicrobia secA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 Bacteria 27XJU@189775,2G603@200795,COG0653@1,COG0653@2 NA|NA|NA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane MAG.T1.121_00089 1382356.JQMP01000003_gene2472 1.2e-22 113.2 Thermomicrobia ybaZ GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0005488,GO:0005515,GO:0019899,GO:0097159,GO:1901363 2.1.1.63 ko:K00567,ko:K07443 ko00000,ko01000,ko03400 Bacteria 27YDT@189775,2G7CY@200795,COG3695@1,COG3695@2 NA|NA|NA L 6-O-methylguanine DNA methyltransferase, DNA binding domain MAG.T1.121_00090 479434.Sthe_1493 1.6e-24 120.2 Thermomicrobia thiE2 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 Bacteria 27YDG@189775,2G9BW@200795,COG0352@1,COG0352@2 NA|NA|NA H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) MAG.T1.121_00091 309801.trd_0400 7.5e-43 180.6 Thermomicrobia thiE GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3,2.7.1.49,2.7.4.7 ko:K00788,ko:K14153 ko00730,ko01100,map00730,map01100 M00127 R03223,R03471,R04509,R10712 RC00002,RC00017,RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 Bacteria 27Y70@189775,2G6P0@200795,COG0352@1,COG0352@2 NA|NA|NA H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) MAG.T1.121_00092 479434.Sthe_1495 2.4e-102 378.6 Thermomicrobia thiG GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.10 ko:K03149 ko00730,ko01100,map00730,map01100 R10247 RC03096,RC03097,RC03461 ko00000,ko00001,ko01000 iECABU_c1320.ECABU_c45060,iECO26_1355.ECO26_5099,ic_1306.c4947 Bacteria 27XT9@189775,2G6DX@200795,COG2022@1,COG2022@2 NA|NA|NA H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S MAG.T1.121_00093 479434.Sthe_1496 6.6e-76 290.8 Thermomicrobia thiD GO:0008150,GO:0040007 2.5.1.3,2.7.1.35,2.7.1.49,2.7.4.7,4.1.99.17 ko:K00868,ko:K00941,ko:K03147,ko:K21219 ko00730,ko00750,ko01100,map00730,map00750,map01100 M00127 R00174,R01909,R02493,R03223,R03471,R03472,R04509,R10712 RC00002,RC00017,RC00224,RC03251,RC03252,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS03115 Bacteria 27XQP@189775,2G5R7@200795,COG0351@1,COG0351@2 NA|NA|NA H Phosphomethylpyrimidine kinase MAG.T1.121_00094 479434.Sthe_1636 9.8e-21 106.3 Thermomicrobia Bacteria 27YI9@189775,28VU2@1,2GA15@200795,2ZHVR@2 NA|NA|NA MAG.T1.121_00095 309801.trd_1458 3.9e-152 544.7 Thermomicrobia gabT 2.6.1.19 ko:K00823 ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 27XJH@189775,2G5SK@200795,COG0160@1,COG0160@2 NA|NA|NA H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family MAG.T1.121_00096 479434.Sthe_1464 7.3e-109 401.0 Thermomicrobia mshA 2.4.1.250 ko:K15521 ko00000,ko01000 Bacteria 27XJX@189775,2GA6I@200795,COG0297@1,COG0297@2 NA|NA|NA G Glycosyl transferase 4-like domain MAG.T1.121_00099 479434.Sthe_0695 1e-118 433.7 Thermomicrobia selA GO:0003674,GO:0003824,GO:0004125,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009059,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0019752,GO:0019842,GO:0030170,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0090304,GO:0097056,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.9.1.1 ko:K01042 ko00450,ko00970,map00450,map00970 R08219 RC01246 ko00000,ko00001,ko01000 iECP_1309.ECP_3693,iSbBS512_1146.SbBS512_E4006 Bacteria 27XPD@189775,2G5VV@200795,COG1921@1,COG1921@2 NA|NA|NA H Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis MAG.T1.121_00100 479434.Sthe_0414 5.9e-144 518.1 Thermomicrobia dnaG GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 ko:K02316 ko03030,map03030 ko00000,ko00001,ko01000,ko03032 Bacteria 27XKY@189775,2G65X@200795,COG0358@1,COG0358@2 NA|NA|NA L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication MAG.T1.121_00101 309801.trd_0423 1.6e-103 382.9 Thermomicrobia dgt GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.1.5.1 ko:K01129 ko00230,map00230 R01856 RC00017 ko00000,ko00001,ko01000 Bacteria 27XIJ@189775,2G5VZ@200795,COG0232@1,COG0232@2 NA|NA|NA F Belongs to the dGTPase family. Type 2 subfamily MAG.T1.121_00102 479434.Sthe_0771 4.9e-198 698.0 Thermomicrobia pcrA 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 27Y2J@189775,2G5XF@200795,COG0210@1,COG0210@2 NA|NA|NA L UvrD-like helicase C-terminal domain MAG.T1.121_00104 479434.Sthe_1310 2.5e-79 302.8 Thermomicrobia recF GO:0000731,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0018130,GO:0019438,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901576 ko:K03629,ko:K07459 ko03440,map03440 ko00000,ko00001,ko03400 Bacteria 27XJY@189775,2G60N@200795,COG1195@1,COG1195@2 NA|NA|NA L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP MAG.T1.121_00105 479434.Sthe_1312 1.9e-92 346.3 Thermomicrobia dnaN GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 27XHQ@189775,2G641@200795,COG0592@1,COG0592@2 NA|NA|NA L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria MAG.T1.121_00106 479434.Sthe_1313 5.1e-57 227.6 Thermomicrobia Bacteria 27Y76@189775,2C5T0@1,2G9CN@200795,337HV@2 NA|NA|NA MAG.T1.121_00109 1151122.AQYD01000005_gene3434 1.1e-56 226.9 Actinobacteria Bacteria 2IMQQ@201174,COG2267@1,COG2267@2 NA|NA|NA I Alpha beta hydrolase MAG.T1.121_00112 101510.RHA1_ro04805 6.3e-195 687.2 Nocardiaceae Bacteria 2GITS@201174,4FXZ9@85025,COG0477@1,COG0477@2 NA|NA|NA EGP major facilitator superfamily MAG.T1.121_00113 492774.JQMB01000016_gene1590 8.3e-112 410.2 Rhizobiaceae arcC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.7.2.2 ko:K00926 ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200 R00150,R01395 RC00002,RC00043,RC02803,RC02804 ko00000,ko00001,ko01000 iE2348C_1286.E2348C_0454,iECED1_1282.ECED1_0540,iECUMN_1333.ECUMN_0561,iEcE24377_1341.EcE24377A_0559,iG2583_1286.G2583_0641,iJN746.PP_0999 Bacteria 1MWXC@1224,2TVMD@28211,4BA59@82115,COG0549@1,COG0549@2 NA|NA|NA E Reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP MAG.T1.121_00114 1283287.KB822577_gene3314 7e-271 940.3 Propionibacteriales 3.6.3.8 ko:K01537 ko00000,ko01000 3.A.3.2 Bacteria 2GJJC@201174,4DPKG@85009,COG0474@1,COG0474@2 NA|NA|NA P E1-E2 ATPase MAG.T1.121_00115 1240350.AMZE01000025_gene1684 2.2e-134 485.3 Gammaproteobacteria argF GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0033554,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 iAF1260.b0273,iECDH10B_1368.ECDH10B_0261,iECS88_1305.ECS88_4841,iHN637.CLJU_RS12430,iJO1366.b0273,iJR904.b0273,iY75_1357.Y75_RS01410 Bacteria 1MUFM@1224,1RQ59@1236,COG0078@1,COG0078@2 NA|NA|NA E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline MAG.T1.121_00116 1283287.KB822577_gene3308 1.5e-174 619.4 Propionibacteriales arcD Bacteria 2HK5U@201174,4DT6Y@85009,COG1288@1,COG1288@2 NA|NA|NA S C4-dicarboxylate anaerobic carrier MAG.T1.121_00118 1121946.AUAX01000010_gene3765 2.6e-172 611.7 Micromonosporales arcA 3.5.3.6 ko:K01478 ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130 R00552 RC00177 ko00000,ko00001,ko01000 Bacteria 2GJTR@201174,4D9VS@85008,COG2235@1,COG2235@2 NA|NA|NA E Amidinotransferase MAG.T1.121_00119 1380356.JNIK01000015_gene2351 8.4e-97 360.9 Actinobacteria ybaT GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009268,GO:0009628,GO:0010035,GO:0010038,GO:0016020,GO:0042221,GO:0044464,GO:0046688,GO:0050896,GO:0071944,GO:0097501,GO:1990169 ko:K16263 ko00000,ko02000 2.A.3.13 Bacteria 2IDWU@201174,COG0531@1,COG0531@2 NA|NA|NA E Amino acid permease MAG.T1.121_00120 1032480.MLP_06320 5e-09 67.4 Actinobacteria Bacteria 2E35Q@1,2GS2Q@201174,32Y5M@2 NA|NA|NA S Short C-terminal domain MAG.T1.121_00121 42256.RradSPS_0358 3.8e-96 359.8 Rubrobacteria ko:K03556 ko00000,ko03000 Bacteria 2HENR@201174,4CPC9@84995,COG2909@1,COG2909@2 NA|NA|NA K helix_turn_helix, Lux Regulon MAG.T1.121_00122 1210908.HSB1_39750 1.3e-17 96.7 Euryarchaeota Archaea 2XXXJ@28890,COG4894@1,arCOG03995@2157 NA|NA|NA S LURP-one-related MAG.T1.121_00123 1380370.JIBA01000006_gene3403 3.1e-07 62.0 Actinobacteria Bacteria 2IFQ5@201174,COG4803@1,COG4803@2 NA|NA|NA S membrane protein of uknown function UCP014873 MAG.T1.121_00124 118166.JH976537_gene4047 6.2e-29 134.0 Oscillatoriales Bacteria 1G531@1117,1HAJ5@1150,COG4803@1,COG4803@2 NA|NA|NA S Protein of unknown function (DUF1269) MAG.T1.121_00126 67356.KL575592_gene2514 2.7e-117 429.1 Actinobacteria Bacteria 2GKEK@201174,COG4320@1,COG4320@2 NA|NA|NA K protein conserved in bacteria MAG.T1.121_00127 1298863.AUEP01000001_gene752 3.3e-176 625.2 Propionibacteriales ko:K03321 ko00000,ko02000 2.A.53.3 Bacteria 2GJCB@201174,4DP1B@85009,COG0659@1,COG0659@2 NA|NA|NA P Sulfate permease family MAG.T1.121_00128 1209984.BN978_04221 2.1e-40 171.8 Mycobacteriaceae yeaO Bacteria 23A9X@1762,2IQC0@201174,COG3189@1,COG3189@2 NA|NA|NA S Protein of unknown function, DUF488 MAG.T1.121_00131 471853.Bcav_0736 7.7e-28 130.2 Actinobacteria Bacteria 2IIN1@201174,COG4803@1,COG4803@2 NA|NA|NA S membrane protein of uknown function UCP014873 MAG.T1.121_00132 471853.Bcav_0752 5.3e-23 114.8 Actinobacteria Bacteria 29VND@1,2I845@201174,33797@2 NA|NA|NA MAG.T1.121_00133 118166.JH976537_gene4083 2.4e-117 428.7 Oscillatoriales Bacteria 1G4C8@1117,1H943@1150,COG1262@1,COG1262@2 NA|NA|NA S Sulfatase-modifying factor enzyme 1 MAG.T1.121_00135 710111.FraQA3DRAFT_1888 6.3e-78 297.4 Frankiales ksgA GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182,2.1.1.197,2.5.1.134 ko:K02169,ko:K02528,ko:K17216,ko:K17462 ko00270,ko00780,ko01100,ko01230,map00270,map00780,map01100,map01230 M00572,M00609 R09543,R10305,R10404,R10716 RC00003,RC00020,RC00069,RC00460,RC03257 ko00000,ko00001,ko00002,ko01000,ko03009 Bacteria 2GIZ8@201174,4EW0R@85013,COG0030@1,COG0030@2 NA|NA|NA J Methyltransferase domain MAG.T1.121_00136 485913.Krac_3174 2.6e-38 165.2 Chloroflexi cca 2.7.7.19,2.7.7.72 ko:K00970,ko:K00974,ko:K19545 ko03013,ko03018,map03013,map03018 R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko01504,ko03016,ko03019 Bacteria 2G8X7@200795,COG0617@1,COG0617@2 NA|NA|NA J Aminoglycoside-2''-adenylyltransferase MAG.T1.121_00137 436229.JOEH01000011_gene5495 1.8e-22 112.5 Actinobacteria Bacteria 2IGAX@201174,COG1846@1,COG1846@2 NA|NA|NA K Winged helix DNA-binding domain MAG.T1.121_00138 1229780.BN381_130130 1.4e-96 360.1 unclassified Actinobacteria (class) Bacteria 2GK06@201174,3UWB0@52018,COG0477@1,COG0477@2 NA|NA|NA U Transmembrane secretion effector MAG.T1.121_00139 479434.Sthe_1720 8.3e-158 563.5 Chloroflexi 3.1.2.1 ko:K01067 ko00620,map00620 R00227 RC00004,RC00012 ko00000,ko00001,ko01000 Bacteria 2G60V@200795,COG0427@1,COG0427@2 NA|NA|NA C PFAM Acetyl-CoA hydrolase transferase MAG.T1.121_00140 383372.Rcas_2371 1.3e-145 523.5 Chloroflexia sulP GO:0003333,GO:0003674,GO:0005215,GO:0005310,GO:0005326,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0008272,GO:0008509,GO:0008514,GO:0015075,GO:0015103,GO:0015116,GO:0015138,GO:0015141,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015238,GO:0015318,GO:0015556,GO:0015698,GO:0015711,GO:0015740,GO:0015741,GO:0015744,GO:0015800,GO:0015807,GO:0015810,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070778,GO:0071422,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0098656,GO:0098660,GO:0098661,GO:1901682,GO:1902358,GO:1902475,GO:1903825,GO:1905039 ko:K03321 ko00000,ko02000 2.A.53.3 iSbBS512_1146.SbBS512_E1370 Bacteria 2G7JI@200795,3768W@32061,COG0659@1,COG0659@2 NA|NA|NA P PFAM Sulfate transporter antisigma-factor antagonist STAS MAG.T1.121_00141 1125863.JAFN01000001_gene3206 8.7e-94 350.9 Deltaproteobacteria Bacteria 1QZ3W@1224,2WM59@28221,42PKB@68525,COG2159@1,COG2159@2 NA|NA|NA L PFAM transposase, IS4 family protein MAG.T1.121_00142 479434.Sthe_1318 4.4e-49 201.1 Chloroflexi ppiB GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0031224,GO:0031226,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.7.11.1,5.2.1.8 ko:K01802,ko:K03768,ko:K12132 ko00000,ko01000,ko01001,ko03110 Bacteria 2G6RE@200795,COG0652@1,COG0652@2 NA|NA|NA M PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides MAG.T1.121_00143 639282.DEFDS_1810 4.3e-53 214.5 Deferribacteres ko:K06951 ko00000 Bacteria 2GFCZ@200930,COG2316@1,COG2316@2 NA|NA|NA S Metal dependent phosphohydrolases with conserved 'HD' motif. MAG.T1.121_00144 1120985.AUMI01000015_gene1369 2.7e-95 355.5 Negativicutes queA GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 ko:K07568 ko00000,ko01000,ko03016 Bacteria 1TPKD@1239,4H1WD@909932,COG0809@1,COG0809@2 NA|NA|NA H Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) MAG.T1.121_00145 479434.Sthe_1321 7.8e-133 480.3 Thermomicrobia ruvB GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 3.6.4.12 ko:K03551 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 27Y08@189775,2G5QQ@200795,COG2255@1,COG2255@2 NA|NA|NA L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing MAG.T1.121_00152 1437448.AZRT01000002_gene2318 6e-29 133.7 Brucellaceae Bacteria 1J45I@118882,1N15G@1224,2UCYE@28211,COG0346@1,COG0346@2 NA|NA|NA E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily MAG.T1.121_00153 1382356.JQMP01000003_gene1326 3.5e-83 315.5 Thermomicrobia cinA 3.5.1.42 ko:K03742,ko:K03743 ko00760,map00760 R02322 RC00100 ko00000,ko00001,ko01000 Bacteria 27XMX@189775,2G6DU@200795,COG1058@1,COG1058@2,COG1546@1,COG1546@2 NA|NA|NA S Probable molybdopterin binding domain MAG.T1.121_00154 479434.Sthe_0889 1.5e-16 92.8 Thermomicrobia ybeY GO:0000469,GO:0000478,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006355,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016072,GO:0016151,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0019219,GO:0019222,GO:0019538,GO:0022613,GO:0030490,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043244,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141 2.6.99.2,3.5.4.5 ko:K01489,ko:K03474,ko:K03595,ko:K07042 ko00240,ko00750,ko00983,ko01100,map00240,map00750,map00983,map01100 M00124 R01878,R02485,R05838,R08221 RC00074,RC00514,RC01476 ko00000,ko00001,ko00002,ko01000,ko03009,ko03029 Bacteria 27YHX@189775,2G78D@200795,COG0319@1,COG0319@2 NA|NA|NA J Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA MAG.T1.121_00155 309801.trd_1291 8e-32 143.7 Thermomicrobia yqeY ko:K09117 ko00000 Bacteria 27YG2@189775,2G7B8@200795,COG1610@1,COG1610@2 NA|NA|NA S Yqey-like protein MAG.T1.121_00156 479434.Sthe_0786 1.2e-23 115.9 Thermomicrobia hinT GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019478,GO:0019752,GO:0043436,GO:0043530,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046144,GO:0046395,GO:0046416,GO:0046436,GO:0055130,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.1.1.226,2.1.1.227 ko:K02503,ko:K06442 ko00000,ko01000,ko03009,ko04147 Bacteria 27YE1@189775,2G6VV@200795,COG0537@1,COG0537@2 NA|NA|NA FG Scavenger mRNA decapping enzyme C-term binding MAG.T1.121_00157 1122132.AQYH01000005_gene443 1.1e-120 439.9 Rhizobiaceae uxuA 4.2.1.8 ko:K01686 ko00040,ko01100,map00040,map01100 M00061 R05606 RC00543 ko00000,ko00001,ko00002,ko01000 Bacteria 1MWYD@1224,2U42Y@28211,4BD7S@82115,COG1312@1,COG1312@2 NA|NA|NA G D-mannonate dehydratase (UxuA) MAG.T1.121_00158 1122132.AQYH01000005_gene446 8.8e-131 473.8 Alphaproteobacteria ko:K02027 M00207 ko00000,ko00002,ko02000 3.A.1.1 Bacteria 1MXY4@1224,2TS7N@28211,COG1653@1,COG1653@2 NA|NA|NA G Bacterial extracellular solute-binding protein MAG.T1.121_00159 1122132.AQYH01000005_gene445 8.1e-107 393.7 Rhizobiaceae ko:K15771 ko02010,map02010 M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1.16,3.A.1.1.2 Bacteria 1MWB7@1224,2TUAN@28211,4B76N@82115,COG1175@1,COG1175@2 NA|NA|NA G ABC transporter permease MAG.T1.121_00160 1122132.AQYH01000005_gene444 3.4e-99 368.2 Rhizobiaceae ko:K02025,ko:K02026 M00207 ko00000,ko00002,ko02000 3.A.1.1 Bacteria 1N4I0@1224,2TT14@28211,4BMAS@82115,COG0395@1,COG0395@2 NA|NA|NA G Binding-protein-dependent transport system inner membrane component MAG.T1.121_00161 479434.Sthe_0785 1.1e-54 220.3 Thermomicrobia fpg 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 27YBP@189775,2G6BB@200795,COG0266@1,COG0266@2 NA|NA|NA L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates MAG.T1.121_00162 1089549.AZUQ01000001_gene166 1e-49 203.4 Glycomycetales rpsD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 ko:K02986 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GIRX@201174,4EYD4@85014,COG0522@1,COG0522@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit MAG.T1.121_00163 649831.L083_5499 1.2e-68 267.3 Micromonosporales 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 R06200,R11307,R11308 ko00000,ko00001,ko01000 GH5,GH9 Bacteria 2I8D7@201174,4DATI@85008,COG3420@1,COG3420@2 NA|NA|NA P Right handed beta helix region MAG.T1.121_00166 292459.STH1283 3.9e-149 535.0 Clostridia fepC 3.6.3.34 ko:K02013 ko02010,map02010 M00240 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 Bacteria 1TP2Q@1239,2492Z@186801,COG1120@1,COG1120@2 NA|NA|NA HP Abc transporter MAG.T1.121_00167 479434.Sthe_2584 1.9e-88 332.8 Thermomicrobia ko:K02015 ko02010,map02010 M00240 ko00000,ko00001,ko00002,ko02000 3.A.1.14 Bacteria 27Z8M@189775,2GAPB@200795,COG0609@1,COG0609@2 NA|NA|NA P FecCD transport family MAG.T1.121_00168 479434.Sthe_2585 4.9e-100 371.3 Chloroflexi yfiZ ko:K02015 ko02010,map02010 M00240 ko00000,ko00001,ko00002,ko02000 3.A.1.14 iYO844.BSU08450 Bacteria 2G6E8@200795,COG0609@1,COG0609@2 NA|NA|NA P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily MAG.T1.121_00169 1463864.JOGO01000007_gene637 3.6e-37 162.2 Actinobacteria viuB Bacteria 2GN5R@201174,COG2375@1,COG2375@2 NA|NA|NA P siderophore-interacting protein MAG.T1.121_00170 525904.Tter_2143 5e-21 107.5 Bacteria ko:K07005 ko00000 Bacteria COG3576@1,COG3576@2 NA|NA|NA S Pyridoxamine 5'-phosphate oxidase MAG.T1.121_00171 1192034.CAP_3999 1.3e-120 439.5 Myxococcales pip 3.4.11.5 ko:K01259 ko00330,map00330 R00135 ko00000,ko00001,ko01000,ko01002 Bacteria 1MWW8@1224,2WKXS@28221,2YUES@29,42P6R@68525,COG0596@1,COG0596@2 NA|NA|NA E Belongs to the peptidase S33 family MAG.T1.121_00172 867845.KI911784_gene3421 2.1e-204 718.4 Chloroflexia argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 iSBO_1134.SBO_3210,iSbBS512_1146.SbBS512_E3599 Bacteria 2G5ME@200795,374YM@32061,COG0137@1,COG0137@2 NA|NA|NA E Belongs to the argininosuccinate synthase family. Type MAG.T1.121_00173 670292.JH26_09940 3.9e-30 138.3 Methylobacteriaceae Bacteria 1JXCW@119045,1R5AT@1224,2TV9P@28211,COG2128@1,COG2128@2 NA|NA|NA S Carboxymuconolactone decarboxylase family MAG.T1.121_00174 749414.SBI_09467 1.7e-13 82.8 Actinobacteria ko:K07452 ko00000,ko01000,ko02048 Bacteria 2IFY8@201174,COG2128@1,COG2128@2,COG4950@1,COG4950@2 NA|NA|NA S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity MAG.T1.121_00175 1205910.B005_4590 7.5e-48 197.2 Streptosporangiales Bacteria 2GKCF@201174,4EJ7H@85012,COG3576@1,COG3576@2 NA|NA|NA S Pyridoxamine 5'-phosphate oxidase MAG.T1.121_00178 479434.Sthe_0777 3.2e-270 937.6 Thermomicrobia ftsH GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0030163,GO:0042623,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 ko:K03798 M00742 ko00000,ko00002,ko01000,ko01002,ko03110 Bacteria 27XT6@189775,2G5J3@200795,COG0465@1,COG0465@2 NA|NA|NA O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins MAG.T1.121_00179 479434.Sthe_0776 5.4e-56 224.2 Bacteria hpt GO:0003674,GO:0003824,GO:0004422,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006188,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0043094,GO:0043101,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0052657,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.8,6.3.4.19 ko:K00760,ko:K04075,ko:K15780 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 R00190,R01132,R01229,R02142,R08237,R08238,R08245,R09597 RC00063,RC00122,RC02633,RC02634 ko00000,ko00001,ko01000,ko03016 Bacteria COG0634@1,COG0634@2 NA|NA|NA F Belongs to the purine pyrimidine phosphoribosyltransferase family MAG.T1.121_00180 479434.Sthe_0775 4.7e-42 179.1 Thermomicrobia tilS GO:0008150,GO:0040007 2.4.2.8,6.3.4.19 ko:K00760,ko:K04075,ko:K15780 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 R00190,R01132,R01229,R02142,R08237,R08238,R08245,R09597 RC00063,RC00122,RC02633,RC02634 ko00000,ko00001,ko01000,ko03016 Bacteria 27XGD@189775,2G6AD@200795,COG0037@1,COG0037@2 NA|NA|NA DF Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine MAG.T1.121_00182 479434.Sthe_1304 7.7e-63 247.7 Thermomicrobia folD GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 Bacteria 27YC5@189775,2G6BA@200795,COG0190@1,COG0190@2 NA|NA|NA F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate MAG.T1.121_00183 309801.trd_0736 1.8e-26 125.6 Thermomicrobia 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 27YIS@189775,2GBAN@200795,COG1396@1,COG1396@2 NA|NA|NA K Helix-turn-helix XRE-family like proteins MAG.T1.121_00184 309801.trd_0738 1.8e-308 1065.4 Thermomicrobia dnaE GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 27XEX@189775,2G5IY@200795,COG0587@1,COG0587@2 NA|NA|NA L Bacterial DNA polymerase III alpha subunit MAG.T1.121_00185 1382356.JQMP01000004_gene31 2e-47 196.8 Thermomicrobia murE 6.3.2.13,6.3.2.29,6.3.2.30 ko:K01928,ko:K03802 ko00300,ko00550,map00300,map00550 R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 Bacteria 27Y91@189775,2G944@200795,COG0769@1,COG0769@2 NA|NA|NA M Mur ligase, middle domain protein MAG.T1.121_00186 1399115.U719_11970 6.1e-34 151.0 Bacillales incertae sedis rdgB GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035870,GO:0036220,GO:0036222,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046983,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 2.5.1.15,3.6.1.66,5.1.1.3 ko:K00796,ko:K01776,ko:K02428 ko00230,ko00471,ko00790,ko01100,map00230,map00471,map00790,map01100 M00126,M00841 R00260,R00426,R00720,R01855,R02100,R02720,R03066,R03067,R03531 RC00002,RC00121,RC00302,RC00842 ko00000,ko00001,ko00002,ko01000,ko01011 iAF987.Gmet_1875,iEC55989_1330.EC55989_3247,iECO111_1330.ECO111_3702,iECSE_1348.ECSE_3222,iECW_1372.ECW_m3212,iEKO11_1354.EKO11_0774,iEcE24377_1341.EcE24377A_3298,iWFL_1372.ECW_m3212 Bacteria 1V6RN@1239,3WE4M@539002,4HCP6@91061,COG0127@1,COG0127@2 NA|NA|NA F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions MAG.T1.121_00187 479434.Sthe_1296 9.9e-45 187.2 Thermomicrobia tatD ko:K03424 ko00000,ko01000 Bacteria 27Y6N@189775,2G6F2@200795,COG0084@1,COG0084@2 NA|NA|NA L TatD related DNase MAG.T1.121_00188 479434.Sthe_1295 8.5e-198 696.8 Thermomicrobia 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 Bacteria 27XFD@189775,2G5T5@200795,COG0449@1,COG0449@2 NA|NA|NA M Glutamine amidotransferase domain MAG.T1.121_00189 479434.Sthe_1293 2.4e-157 562.0 Thermomicrobia purB GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 iLJ478.TM1095,iSB619.SA_RS09895 Bacteria 27XJC@189775,2G607@200795,COG0015@1,COG0015@2 NA|NA|NA F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily MAG.T1.121_00190 479434.Sthe_1292 1.1e-89 336.7 Thermomicrobia purC GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6,6.3.4.13 ko:K01923,ko:K01945,ko:K03566 ko00230,ko01100,ko01110,ko01130,ko02026,map00230,map01100,map01110,map01130,map02026 M00048 R04144,R04591 RC00064,RC00090,RC00162,RC00166 ko00000,ko00001,ko00002,ko01000,ko03000 Bacteria 27Y59@189775,2G6S5@200795,COG0152@1,COG0152@2 NA|NA|NA F SAICAR synthetase MAG.T1.121_00191 935948.KE386494_gene647 2.3e-10 71.2 Thermoanaerobacterales purS 6.3.2.6,6.3.5.3 ko:K01923,ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463,R04591 RC00010,RC00064,RC00162,RC01160 ko00000,ko00001,ko00002,ko01000 iYO844.BSU06460 Bacteria 1VEH1@1239,24R3W@186801,42H8G@68295,COG1828@1,COG1828@2 NA|NA|NA F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL MAG.T1.121_00192 479434.Sthe_1290 5.1e-77 294.3 Thermomicrobia purQ GO:0003674,GO:0003824,GO:0004642,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 Bacteria 27XM6@189775,2G6R9@200795,COG0047@1,COG0047@2 NA|NA|NA F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL MAG.T1.121_00193 479434.Sthe_1289 3.9e-256 891.0 Thermomicrobia purL GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 Bacteria 27XNA@189775,2G5Z1@200795,COG0046@1,COG0046@2 NA|NA|NA F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL MAG.T1.121_00194 479434.Sthe_1288 2.5e-187 661.8 Thermomicrobia purF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009507,GO:0009536,GO:0040007,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 Bacteria 27XUW@189775,2G61T@200795,COG0034@1,COG0034@2 NA|NA|NA F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine MAG.T1.121_00195 479434.Sthe_1287 1.4e-121 443.0 Thermomicrobia gcvT 2.1.1.341,2.1.2.10 ko:K00605,ko:K15066 ko00260,ko00627,ko00630,ko00670,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00627,map00630,map00670,map01100,map01110,map01120,map01130,map01200 M00532 R01221,R02300,R04125,R09271,R10136 RC00022,RC00069,RC00113,RC00183,RC00392,RC02834 ko00000,ko00001,ko00002,ko01000 Bacteria 27XV3@189775,2G5VA@200795,COG0404@1,COG0404@2 NA|NA|NA E The glycine cleavage system catalyzes the degradation of glycine MAG.T1.121_00196 479434.Sthe_1286 2e-38 165.2 Thermomicrobia gcvH GO:0001505,GO:0003674,GO:0003824,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0017144,GO:0019464,GO:0019752,GO:0031405,GO:0031406,GO:0033293,GO:0036094,GO:0042133,GO:0042135,GO:0042737,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901681 ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 iE2348C_1286.E2348C_3156,iNJ661.Rv1826,iPC815.YPO0906 Bacteria 27YEK@189775,2G6XE@200795,COG0509@1,COG0509@2 NA|NA|NA E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein MAG.T1.121_00197 479434.Sthe_1285 6.2e-148 530.8 Thermomicrobia gcvPA GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006807,GO:0008150,GO:0008152,GO:0009069,GO:0009987,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019752,GO:0032991,GO:0042133,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901605,GO:1902494,GO:1990204 1.4.4.2 ko:K00281,ko:K00282 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 Bacteria 27Y3Y@189775,2G5NI@200795,COG0403@1,COG0403@2 NA|NA|NA E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor MAG.T1.121_00198 479434.Sthe_1284 1.8e-155 555.8 Thermomicrobia der GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 1.1.1.399,1.1.1.95 ko:K00058,ko:K03977 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko03009,ko04147 Bacteria 27XGH@189775,2G5M0@200795,COG1160@1,COG1160@2 NA|NA|NA S GTPase that plays an essential role in the late steps of ribosome biogenesis MAG.T1.121_00199 497964.CfE428DRAFT_2042 7.8e-84 317.4 Verrucomicrobia galE 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 Bacteria 46SIR@74201,COG1087@1,COG1087@2 NA|NA|NA M Belongs to the NAD(P)-dependent epimerase dehydratase family MAG.T1.121_00200 944479.JQLX01000010_gene414 2.4e-79 302.0 Desulfurellales glyA GO:0001505,GO:0003674,GO:0003824,GO:0004372,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006546,GO:0006563,GO:0006565,GO:0006730,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009070,GO:0009071,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016741,GO:0016742,GO:0017144,GO:0019264,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042133,GO:0042135,GO:0042136,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 iG2583_1286.G2583_3081,iIT341.HP0183 Bacteria 1MUIS@1224,2M6D8@213113,2WJ3C@28221,42M0T@68525,COG0112@1,COG0112@2 NA|NA|NA E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism MAG.T1.121_00201 357808.RoseRS_2958 2.2e-59 236.1 Chloroflexia Bacteria 2G6YP@200795,374VD@32061,COG0438@1,COG0438@2 NA|NA|NA M PFAM glycosyl transferase group 1 MAG.T1.121_00202 316274.Haur_3900 5.6e-90 337.4 Chloroflexia 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 R01009 RC00005 ko00000,ko00001,ko01000,ko01003 GT2 Bacteria 2GBIQ@200795,374ZU@32061,COG1216@1,COG1216@2 NA|NA|NA S PFAM glycosyl transferase family 2 MAG.T1.121_00203 316274.Haur_3899 4.9e-113 414.5 Chloroflexia 4.2.1.46,5.1.3.2 ko:K01710,ko:K01784,ko:K13318,ko:K13322,ko:K16439,ko:K19857 ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130 M00361,M00362,M00632,M00793,M00798,M00799,M00800 R00291,R02984,R06436,R06513,R06629,R11042,R11047 RC00182,RC00261,RC00289,RC00402 ko00000,ko00001,ko00002,ko01000 Bacteria 2G7KN@200795,375A6@32061,COG0451@1,COG0451@2 NA|NA|NA M PFAM NAD-dependent epimerase dehydratase MAG.T1.121_00205 999541.bgla_2g12030 2.1e-41 176.8 Burkholderiaceae ko:K03449 ko00000,ko02000 2.A.1.17 Bacteria 1JZMP@119060,1MXGT@1224,2VHPV@28216,COG2807@1,COG2807@2 NA|NA|NA P PFAM major facilitator superfamily MFS_1 MAG.T1.121_00206 383372.Rcas_1703 7.2e-25 120.9 Chloroflexia Bacteria 2G90F@200795,377N7@32061,COG4636@1,COG4636@2 NA|NA|NA S Putative restriction endonuclease MAG.T1.121_00207 234267.Acid_6579 1.9e-131 475.7 Acidobacteria 5.1.1.4 ko:K01777 ko00330,ko01100,map00330,map01100 R01255 RC00479 ko00000,ko00001,ko01000 Bacteria 3Y6TR@57723,COG3938@1,COG3938@2 NA|NA|NA E Proline racemase MAG.T1.121_00208 1231190.NA8A_15046 3.6e-156 558.5 Phyllobacteriaceae MA20_00585 1.1.3.47 ko:K16873 ko00365,ko01120,map00365,map01120 R10212,R10216,R10858 RC00075,RC03291 ko00000,ko00001,ko01000 Bacteria 1N0NP@1224,2TQSK@28211,43NQZ@69277,COG2303@1,COG2303@2 NA|NA|NA E GMC oxidoreductase MAG.T1.121_00211 357808.RoseRS_2267 2.6e-48 199.1 Chloroflexia Bacteria 2G725@200795,3779Z@32061,COG3336@1,COG3336@2 NA|NA|NA S Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) MAG.T1.121_00212 379066.GAU_0507 4.7e-10 70.9 Gemmatimonadetes 1.9.3.1 ko:K02277 ko00190,ko01100,map00190,map01100 M00155 ko00000,ko00001,ko00002,ko01000 3.D.4.4 Bacteria 1ZTY7@142182,2EKS3@1,33EFV@2 NA|NA|NA S Prokaryotic Cytochrome C oxidase subunit IV MAG.T1.121_00213 479434.Sthe_1584 9.6e-63 246.9 Thermomicrobia 1.9.3.1 ko:K02276,ko:K02299 ko00190,ko01100,map00190,map01100 M00155,M00417 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.5,3.D.4.6 Bacteria 27YE2@189775,2G74U@200795,COG1845@1,COG1845@2 NA|NA|NA C Cytochrome c oxidase subunit III MAG.T1.121_00214 379066.GAU_0505 1e-212 746.5 Gemmatimonadetes cyoB GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005507,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009055,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009486,GO:0009987,GO:0015002,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015453,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016310,GO:0016491,GO:0016679,GO:0016682,GO:0017144,GO:0019637,GO:0019646,GO:0019693,GO:0020037,GO:0022804,GO:0022857,GO:0022890,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0034641,GO:0042773,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0048038,GO:0048039,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901360,GO:1901363,GO:1901564,GO:1902494,GO:1902600 1.10.3.10,1.10.3.12,1.9.3.1 ko:K02274,ko:K02298,ko:K02827 ko00190,ko01100,map00190,map01100 M00155,M00416,M00417 R00081,R09492,R11335 RC00016,RC00061,RC00819 ko00000,ko00001,ko00002,ko01000 3.D.4.1,3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.5,3.D.4.6 Bacteria 1ZSMG@142182,COG0843@1,COG0843@2 NA|NA|NA C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B MAG.T1.121_00215 1128421.JAGA01000003_gene2731 1.1e-60 240.7 unclassified Bacteria 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 Bacteria 2NNSH@2323,COG1622@1,COG1622@2 NA|NA|NA C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) MAG.T1.121_00217 479434.Sthe_2292 4.9e-235 820.8 Thermomicrobia argS GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 iAF987.Gmet_1434 Bacteria 27XN1@189775,2G6DK@200795,COG0018@1,COG0018@2 NA|NA|NA J DALR anticodon binding domain MAG.T1.121_00218 1033730.CAHG01000017_gene2431 1.7e-10 73.6 Bacteria ko:K02238,ko:K09952 M00429 ko00000,ko00002,ko01000,ko02044,ko02048 3.A.11.1,3.A.11.2 Bacteria COG1525@1,COG1525@2,COG3513@1,COG3513@2 NA|NA|NA L defense response to virus MAG.T1.121_00219 926550.CLDAP_03620 9.7e-39 167.2 Chloroflexi nnrD 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 ko00000,ko01000 Bacteria 2G8T6@200795,COG0062@1,COG0062@2 NA|NA|NA H Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX MAG.T1.121_00220 1206731.BAGB01000144_gene4190 5.3e-81 309.3 Nocardiaceae Bacteria 2GIZ1@201174,4FUTU@85025,COG0515@1,COG0515@2,COG3903@1,COG3903@2 NA|NA|NA K activity, protein serine threonine kinase activity, protein-tyrosine kinase activity, ATP binding, regulation of transcription, DNA-dependent, protein amino acid phosphorylation MAG.T1.121_00221 1206729.BAFZ01000061_gene3857 2.7e-80 307.0 Nocardiaceae Bacteria 2GIZ1@201174,4FUTU@85025,COG2197@1,COG2197@2,COG3903@1,COG3903@2 NA|NA|NA K activity, protein serine threonine kinase activity, protein-tyrosine kinase activity, ATP binding, regulation of transcription, DNA-dependent, protein amino acid phosphorylation MAG.T1.121_00224 935548.KI912159_gene1576 6.4e-39 166.8 Alphaproteobacteria ko:K08234 ko00000 Bacteria 1MZD3@1224,2UB4F@28211,COG0346@1,COG0346@2 NA|NA|NA E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily MAG.T1.121_00225 1192034.CAP_7835 4.5e-77 294.7 Deltaproteobacteria tam 2.1.1.144,2.1.1.197 ko:K00598,ko:K02169 ko00780,ko01100,map00780,map01100 M00572 R09543 RC00003,RC00460 ko00000,ko00001,ko00002,ko01000 Bacteria 1Q2Y3@1224,2WSZV@28221,42V19@68525,COG4106@1,COG4106@2 NA|NA|NA S Methyltransferase domain MAG.T1.121_00226 479434.Sthe_2463 2.2e-98 365.9 Thermomicrobia yurR GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0044424,GO:0044464,GO:0055114 1.4.5.1 ko:K00285 ko00360,map00360 R01374,R09493 RC00006,RC00025 ko00000,ko00001,ko01000 Bacteria 27Y6M@189775,2G6QE@200795,COG0665@1,COG0665@2 NA|NA|NA E NAD(P)-binding Rossmann-like domain MAG.T1.121_00227 1144310.PMI07_002496 1.6e-112 412.9 Rhizobiaceae 4.2.1.6 ko:K01684 ko00052,ko01100,ko01120,map00052,map01100,map01120 M00552 R03033 RC00543 ko00000,ko00001,ko00002,ko01000 Bacteria 1MURK@1224,2U0BF@28211,4BBCF@82115,COG4948@1,COG4948@2 NA|NA|NA M Mandelate racemase muconate MAG.T1.121_00229 479434.Sthe_2425 1.1e-71 277.3 Thermomicrobia truB 1.9.3.1,2.7.7.13,3.2.1.97,5.4.99.25 ko:K00412,ko:K00971,ko:K02275,ko:K02389,ko:K03177,ko:K17624 ko00051,ko00190,ko00520,ko01100,ko01110,ko02020,ko02040,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00051,map00190,map00520,map01100,map01110,map02020,map02040,map04260,map04714,map04932,map05010,map05012,map05016 M00114,M00151,M00152,M00155,M00361,M00362 R00081,R00885 RC00002,RC00016 ko00000,ko00001,ko00002,ko01000,ko02035,ko03016,ko03029 3.D.4.2,3.D.4.4,3.D.4.6 GH101 Bacteria 27Y3B@189775,2G8NS@200795,COG1565@1,COG1565@2 NA|NA|NA S Putative S-adenosyl-L-methionine-dependent methyltransferase MAG.T1.121_00232 684949.ATTJ01000002_gene310 1e-43 184.5 Deinococcus-Thermus ko:K07114 ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 Bacteria 1WIWZ@1297,COG2304@1,COG2304@2 NA|NA|NA S von Willebrand factor, type A MAG.T1.121_00233 1254432.SCE1572_12625 1.8e-16 92.8 Myxococcales ko:K07114 ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 Bacteria 1Q71A@1224,2XA1C@28221,2YW54@29,433UC@68525,COG0789@1,COG0789@2 NA|NA|NA K helix_turn_helix, mercury resistance MAG.T1.121_00234 309801.trd_1364 1.4e-132 479.6 Thermomicrobia 2.8.3.16 ko:K07749 ko00000,ko01000 Bacteria 27XHH@189775,2GABR@200795,COG1804@1,COG1804@2 NA|NA|NA C CoA-transferase family III MAG.T1.121_00235 1125971.ASJB01000083_gene1984 2.3e-52 212.6 Pseudonocardiales Bacteria 2HRVG@201174,4EB71@85010,COG2318@1,COG2318@2 NA|NA|NA S Mycothiol maleylpyruvate isomerase N-terminal domain MAG.T1.121_00236 1267535.KB906767_gene4072 1.3e-146 526.2 Bacteria Bacteria COG4948@1,COG4948@2 NA|NA|NA M carboxylic acid catabolic process MAG.T1.121_00237 937777.Deipe_2474 2.2e-11 76.6 Bacteria Bacteria COG4454@1,COG4454@2 NA|NA|NA MAG.T1.121_00238 1306174.JODP01000024_gene4129 1.1e-12 81.3 Actinobacteria Bacteria 2IATK@201174,COG2197@1,COG2197@2 NA|NA|NA KT helix_turn_helix, Lux Regulon MAG.T1.121_00241 479434.Sthe_0253 1.3e-168 600.9 Thermomicrobia smc GO:0003674,GO:0005488,GO:0005515,GO:0042802 ko:K03529 ko00000,ko03036 Bacteria 27XS8@189775,2G64A@200795,COG1196@1,COG1196@2 NA|NA|NA D Required for chromosome condensation and partitioning MAG.T1.121_00242 479434.Sthe_2183 2.1e-27 130.2 Thermomicrobia ypuF ko:K09763 ko00000 Bacteria 27YQW@189775,2GAFU@200795,COG1547@1,COG1547@2 NA|NA|NA S Domain of unknown function (DUF309) MAG.T1.121_00246 479434.Sthe_2317 1.3e-132 479.9 Thermomicrobia 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 Bacteria 27YVX@189775,2G7S4@200795,COG0154@1,COG0154@2 NA|NA|NA J Amidase MAG.T1.121_00247 861360.AARI_13510 9.2e-15 89.4 Micrococcaceae vanY 3.4.17.14 ko:K07260 ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020 M00651 ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504 Bacteria 1W9EY@1268,2IN2C@201174,COG1876@1,COG1876@2 NA|NA|NA M D-alanyl-D-alanine carboxypeptidase MAG.T1.121_00248 1120950.KB892750_gene6897 5.5e-79 300.8 Bacteria Bacteria COG2227@1,COG2227@2 NA|NA|NA H 3-demethylubiquinone-9 3-O-methyltransferase activity MAG.T1.121_00249 1535287.JP74_09865 8.7e-18 97.4 Alphaproteobacteria Bacteria 1RF4B@1224,2U4TM@28211,COG4821@1,COG4821@2 NA|NA|NA S protein containing SIS (Sugar ISomerase) phosphosugar binding domain MAG.T1.121_00250 1217720.ALOX01000009_gene1826 5.1e-64 251.5 Alphaproteobacteria ywkB ko:K07088 ko00000 Bacteria 1R71W@1224,2UDJI@28211,COG0679@1,COG0679@2 NA|NA|NA S Membrane transport protein MAG.T1.121_00251 543728.Vapar_6005 1.1e-64 253.8 Bacteria Bacteria COG3191@1,COG3191@2 NA|NA|NA EQ aminopeptidase activity MAG.T1.121_00253 479434.Sthe_1173 4.8e-132 478.8 Thermomicrobia Bacteria 27Y2W@189775,2G6AA@200795,COG5427@1,COG5427@2 NA|NA|NA S Uncharacterized membrane protein (DUF2298) MAG.T1.121_00256 479434.Sthe_2914 4.8e-70 271.2 Chloroflexi GO:0003674,GO:0003824,GO:0008080,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747 Bacteria 2G6X6@200795,COG1670@1,COG1670@2 NA|NA|NA J Acetyltransferase (GNAT) domain MAG.T1.121_00257 316274.Haur_3299 1.3e-78 301.6 Bacteria 3.4.17.14 ko:K07260 ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020 M00651 ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504 Bacteria COG2340@1,COG2340@2 NA|NA|NA S peptidase inhibitor activity MAG.T1.121_00258 1051632.TPY_1794 2.9e-32 146.4 Firmicutes Bacteria 1V6VS@1239,COG4129@1,COG4129@2 NA|NA|NA S Fusaric acid resistance protein-like MAG.T1.121_00259 1128421.JAGA01000001_gene2400 2.5e-66 259.2 Bacteria Bacteria COG0739@1,COG0739@2 NA|NA|NA M heme binding MAG.T1.121_00260 479434.Sthe_2294 0.0 1209.5 Thermomicrobia MA20_43170 ko:K06911 ko00000 Bacteria 27XZV@189775,2G5ZQ@200795,COG0247@1,COG0247@2,COG0277@1,COG0277@2 NA|NA|NA C FAD linked oxidases, C-terminal domain MAG.T1.121_00261 1068980.ARVW01000001_gene3569 2e-68 265.4 Pseudonocardiales 3.5.1.19 ko:K08281 ko00760,ko01100,map00760,map01100 R01268 RC00100 ko00000,ko00001,ko01000 Bacteria 2IG6Q@201174,4E2WN@85010,COG1335@1,COG1335@2 NA|NA|NA Q Isochorismatase family MAG.T1.121_00263 42256.RradSPS_1029 3.2e-60 238.8 Rubrobacteria 2.8.1.7,4.4.1.16 ko:K03980,ko:K11717 ko00450,ko01100,map00450,map01100 R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000,ko01011,ko02000 2.A.66.4 Bacteria 2I44K@201174,4CPY1@84995,COG3266@1,COG3266@2 NA|NA|NA S domain, Protein MAG.T1.121_00264 1123226.KB899293_gene87 3e-26 126.3 Paenibacillaceae ypfJ GO:0005575,GO:0005576 ko:K07054 ko00000 Bacteria 1TQKF@1239,26U6Z@186822,4HB7I@91061,COG2321@1,COG2321@2 NA|NA|NA S Metalloprotease MAG.T1.121_00266 485913.Krac_8721 5.9e-115 421.0 Chloroflexi citA 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2G7NR@200795,COG0372@1,COG0372@2 NA|NA|NA H Belongs to the citrate synthase family MAG.T1.121_00267 489825.LYNGBM3L_21110 6.3e-53 214.9 Cyanobacteria Bacteria 1GQTA@1117,COG1215@1,COG1215@2 NA|NA|NA M PFAM Glycosyl transferase family 2 MAG.T1.121_00268 485913.Krac_9866 6.4e-73 281.2 Bacteria Bacteria COG2141@1,COG2141@2 NA|NA|NA C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases MAG.T1.121_00269 675635.Psed_1101 9.7e-54 217.6 Pseudonocardiales kch 3.6.1.22 ko:K03426,ko:K10716 ko00760,ko01100,ko04146,map00760,map01100,map04146 R00103,R03004,R11104 RC00002 ko00000,ko00001,ko01000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 Bacteria 2GKB8@201174,4E0P9@85010,COG1226@1,COG1226@2 NA|NA|NA P K transport system, NAD-binding component MAG.T1.121_00270 760192.Halhy_5338 4.5e-102 378.3 Bacteria Bacteria COG2072@1,COG2072@2 NA|NA|NA P N,N-dimethylaniline monooxygenase activity MAG.T1.121_00271 309801.trd_A0659 1.5e-44 186.8 Thermomicrobia Bacteria 27Z6Z@189775,2GA48@200795,COG0697@1,COG0697@2 NA|NA|NA EG EamA-like transporter family MAG.T1.121_00273 1336208.JADY01000010_gene3299 6.2e-133 480.7 Alphaproteobacteria solA GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016647,GO:0033554,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050131,GO:0050660,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0097159,GO:1901265,GO:1901363 ko:K02846 ko00000,ko01000 iEC042_1314.EC042_1126 Bacteria 1MU7M@1224,2VFJ2@28211,COG0665@1,COG0665@2 NA|NA|NA E FAD dependent oxidoreductase MAG.T1.121_00274 469383.Cwoe_4330 1.8e-27 130.6 Rubrobacteria Bacteria 2GN4Y@201174,4CR97@84995,COG0628@1,COG0628@2 NA|NA|NA S AI-2E family transporter MAG.T1.121_00275 469383.Cwoe_5282 3e-143 515.4 Rubrobacteria ypwA 3.4.17.19 ko:K01299,ko:K03281 ko00000,ko01000,ko01002 2.A.49 Bacteria 2IACE@201174,4CPDZ@84995,COG2317@1,COG2317@2 NA|NA|NA E Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues MAG.T1.121_00276 479435.Kfla_6333 1.1e-114 419.9 Propionibacteriales Bacteria 2GJ6T@201174,4DQ8C@85009,COG2141@1,COG2141@2 NA|NA|NA C Luciferase-like monooxygenase MAG.T1.121_00277 357808.RoseRS_3434 1.6e-89 336.3 Chloroflexi 1.1.1.122 ko:K00064 ko00051,ko00053,ko01100,ko01110,ko01120,map00051,map00053,map01100,map01110,map01120 M00114 R07675,R08926 RC00066,RC00161 ko00000,ko00001,ko00002,ko01000 Bacteria 2G889@200795,COG0667@1,COG0667@2 NA|NA|NA C PFAM aldo keto reductase MAG.T1.121_00278 383372.Rcas_4422 8.6e-99 367.1 Chloroflexi 1.1.1.122 ko:K00064 ko00051,ko00053,ko01100,ko01110,ko01120,map00051,map00053,map01100,map01110,map01120 M00114 R07675,R08926 RC00066,RC00161 ko00000,ko00001,ko00002,ko01000 Bacteria 2G889@200795,COG0667@1,COG0667@2 NA|NA|NA C PFAM aldo keto reductase MAG.T1.121_00279 479434.Sthe_3474 4.9e-139 501.1 Thermomicrobia dho 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 Bacteria 27XRM@189775,2G7WR@200795,COG3964@1,COG3964@2 NA|NA|NA S Amidohydrolase family MAG.T1.121_00280 1158604.I591_01814 1.3e-09 71.2 Enterococcaceae potD2 ko:K02055 ko02024,map02024 M00193 ko00000,ko00001,ko00002,ko02000 3.A.1.11 Bacteria 1TRE1@1239,4B09X@81852,4HDMV@91061,COG0687@1,COG0687@2 NA|NA|NA E Bacterial extracellular solute-binding protein MAG.T1.121_00281 438753.AZC_2722 2.4e-26 126.3 Xanthobacteraceae ko:K02054 ko02024,map02024 M00193 ko00000,ko00001,ko00002,ko02000 3.A.1.11 Bacteria 1R4M5@1224,2U2TZ@28211,3F29I@335928,COG1176@1,COG1176@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component MAG.T1.121_00282 1038862.KB893884_gene598 1.8e-22 113.2 Bradyrhizobiaceae ko:K02053 ko02024,map02024 M00193 ko00000,ko00001,ko00002,ko02000 3.A.1.11 Bacteria 1MZ2N@1224,2U3ZP@28211,3JT39@41294,COG1177@1,COG1177@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component MAG.T1.121_00283 1210908.HSB1_21010 2e-80 306.2 Halobacteria thiQ ko:K02062 ko02010,map02010 M00191 ko00000,ko00001,ko00002,ko02000 3.A.1.19 Archaea 23SSJ@183963,2XTU1@28890,COG3839@1,arCOG00177@2157 NA|NA|NA E COG3842 ABC-type spermidine putrescine transport systems, ATPase components MAG.T1.121_00284 869210.Marky_1921 2.2e-19 102.1 Deinococcus-Thermus Bacteria 1WK3F@1297,COG0517@1,COG0517@2,COG5485@1,COG5485@2 NA|NA|NA S Domain in cystathionine beta-synthase and other proteins. MAG.T1.121_00285 1336208.JADY01000027_gene2250 1.1e-36 160.6 Rhodospirillales 3.1.1.17 ko:K01053 ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220 M00129 R01519,R02933,R03751 RC00537,RC00983 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1MXVD@1224,2JRGE@204441,2TVCW@28211,COG3386@1,COG3386@2 NA|NA|NA G SMP-30/Gluconolaconase/LRE-like region MAG.T1.121_00286 479434.Sthe_3195 1.3e-29 136.3 Bacteria Bacteria COG1225@1,COG1225@2 NA|NA|NA O peroxiredoxin activity MAG.T1.121_00287 1089548.KI783301_gene1779 4.4e-13 82.4 Bacillales incertae sedis 3.2.1.18,3.2.1.52,3.2.1.8 ko:K01181,ko:K01186,ko:K12373,ko:K20276 ko00511,ko00513,ko00520,ko00531,ko00600,ko00603,ko00604,ko01100,ko02024,ko04142,map00511,map00513,map00520,map00531,map00600,map00603,map00604,map01100,map02024,map04142 M00079 R00022,R04018,R06004,R11316 RC00028,RC00049,RC00077 ko00000,ko00001,ko00002,ko01000,ko02042,ko03110 GH20,GH33 Bacteria 1VW0A@1239,3WFP4@539002,4HWE6@91061,COG3055@1,COG3055@2,COG4412@1,COG4412@2,COG5184@1,COG5184@2 NA|NA|NA DZ S-layer homology domain MAG.T1.121_00288 529818.AMSG_11066T0 1e-10 74.7 Eukaryota ko:K20285 ko00000,ko04131 Eukaryota KOG0379@1,KOG0379@2759 NA|NA|NA P nitrile biosynthetic process MAG.T1.121_00289 479434.Sthe_0907 2e-149 535.8 Thermomicrobia 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 Bacteria 27XWA@189775,2G7WJ@200795,COG0154@1,COG0154@2 NA|NA|NA J Belongs to the amidase family MAG.T1.121_00290 1236976.JCM16418_4723 1.4e-20 106.7 Paenibacillaceae Bacteria 1VIGZ@1239,26RC6@186822,2CKD9@1,333BQ@2,4HQNF@91061 NA|NA|NA MAG.T1.121_00291 309801.trd_1495 7.4e-74 284.3 Thermomicrobia acoX 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 R00104 RC00002,RC00078 ko00000,ko00001,ko01000 Bacteria 27YB7@189775,2G8JA@200795,COG0061@1,COG0061@2,COG3199@1,COG3199@2 NA|NA|NA G ATP-NAD kinase MAG.T1.121_00292 231434.JQJH01000002_gene2639 1.4e-43 184.1 Beijerinckiaceae acoC 2.3.1.12 ko:K00627,ko:K06889 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1NU1Q@1224,2U14D@28211,3N9VS@45404,COG0508@1,COG0508@2,COG0596@1,COG0596@2 NA|NA|NA C Biotin-requiring enzyme MAG.T1.121_00293 309801.trd_1494 2.1e-140 505.4 Thermomicrobia acoB ko:K21417 ko00000,ko01000 Bacteria 27XW7@189775,2G84F@200795,COG0022@1,COG0022@2 NA|NA|NA C Transketolase, pyrimidine binding domain MAG.T1.121_00294 309801.trd_1493 3.7e-118 431.4 Thermomicrobia acoA ko:K21416 ko00000,ko01000 Bacteria 27XJB@189775,2G7RR@200795,COG1071@1,COG1071@2 NA|NA|NA C Dehydrogenase E1 component MAG.T1.121_00295 1394178.AWOO02000033_gene8444 1.4e-14 85.9 Streptosporangiales 3.6.4.12 ko:K03655 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 2ISNZ@201174,4EQ6F@85012,COG0640@1,COG0640@2 NA|NA|NA K helix_turn_helix, Arsenical Resistance Operon Repressor MAG.T1.121_00296 521096.Tpau_1954 3.1e-26 125.2 Actinobacteria Bacteria 2IFFI@201174,COG3832@1,COG3832@2 NA|NA|NA S Activator of Hsp90 ATPase MAG.T1.121_00298 309801.trd_0394 1.3e-200 706.1 Thermomicrobia ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 27YZK@189775,2GBUU@200795,COG4166@1,COG4166@2 NA|NA|NA E Bacterial extracellular solute-binding proteins, family 5 Middle MAG.T1.121_00299 1382356.JQMP01000003_gene2465 3.1e-107 395.2 Thermomicrobia ko:K02033,ko:K15581 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 27YY8@189775,2G7K4@200795,COG0601@1,COG0601@2 NA|NA|NA EP Binding-protein-dependent transport system inner membrane component MAG.T1.121_00300 1382356.JQMP01000003_gene2466 4.6e-122 444.5 Thermomicrobia ko:K15582 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 27YWV@189775,2G85N@200795,COG1173@1,COG1173@2 NA|NA|NA EP N-terminal TM domain of oligopeptide transport permease C MAG.T1.121_00301 1246995.AFR_21495 1.8e-42 179.1 Micromonosporales Bacteria 2IKV4@201174,4DEV9@85008,COG1670@1,COG1670@2 NA|NA|NA J Acetyltransferase (GNAT) domain MAG.T1.121_00302 1455608.JDTH01000011_gene2268 4.1e-30 138.7 Halobacteria 3.5.2.10 ko:K01470 ko00330,map00330 R01884 RC00615 ko00000,ko00001,ko01000 Archaea 23V30@183963,2XTQE@28890,COG1402@1,arCOG04536@2157 NA|NA|NA H Creatinine amidohydrolase MAG.T1.121_00303 331869.BAL199_28565 4.6e-86 325.1 unclassified Alphaproteobacteria 2.9.1.1 ko:K01042 ko00450,ko00970,map00450,map00970 R08219 RC01246 ko00000,ko00001,ko01000 Bacteria 1MW8F@1224,2TSR8@28211,4BR1T@82117,COG1921@1,COG1921@2 NA|NA|NA H L-seryl-tRNA selenium transferase MAG.T1.121_00304 316274.Haur_2704 9.4e-58 230.7 Chloroflexia nueM 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 R11945 RC00061 ko00000,ko00001,ko01000 Bacteria 2GAM7@200795,377JJ@32061,COG0702@1,COG0702@2 NA|NA|NA GM NmrA-like family MAG.T1.121_00305 42256.RradSPS_2521 4.8e-110 404.8 Rubrobacteria yodQ 3.5.1.16 ko:K01438 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R00669,R09107 RC00064,RC00300 ko00000,ko00001,ko00002,ko01000 Bacteria 2I8IJ@201174,4CS6S@84995,COG0624@1,COG0624@2 NA|NA|NA E Peptidase dimerisation domain MAG.T1.121_00306 1382306.JNIM01000001_gene593 7e-16 90.9 Bacteria Bacteria COG5607@1,COG5607@2 NA|NA|NA F PFAM CHAD domain containing protein MAG.T1.121_00307 1123023.JIAI01000003_gene2985 8.6e-11 73.6 Pseudonocardiales Bacteria 2GJZH@201174,4E2RA@85010,COG5607@1,COG5607@2 NA|NA|NA S CHAD MAG.T1.121_00308 861299.J421_3843 1.6e-27 130.2 Gemmatimonadetes ppx GO:0003674,GO:0003824,GO:0004309,GO:0005488,GO:0005515,GO:0006082,GO:0006139,GO:0006725,GO:0006793,GO:0006797,GO:0006798,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008894,GO:0009056,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034641,GO:0042594,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:1901360,GO:1901575 3.6.1.11,3.6.1.40 ko:K01524,ko:K07012 ko00230,map00230 R03409 RC00002 ko00000,ko00001,ko01000,ko02048 iECABU_c1320.ECABU_c42590,iECED1_1282.ECED1_4463,iECIAI39_1322.ECIAI39_2643 Bacteria 1ZTH0@142182,COG0248@1,COG0248@2,COG2206@1,COG2206@2 NA|NA|NA FPT Ppx/GppA phosphatase family MAG.T1.121_00310 485913.Krac_6983 4.2e-100 372.5 Bacteria ko:K16089 ko00000,ko02000 1.B.14.1,1.B.14.10 Bacteria COG0526@1,COG0526@2 NA|NA|NA CO cell redox homeostasis MAG.T1.121_00311 479434.Sthe_3098 1.3e-72 280.0 Thermomicrobia rsgA 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 Bacteria 27XYY@189775,2G5IS@200795,COG1162@1,COG1162@2 NA|NA|NA S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit MAG.T1.121_00312 479434.Sthe_2591 2.6e-105 389.0 Thermomicrobia soxB 1.5.3.1 ko:K00303 ko00260,ko01100,map00260,map01100 R00610 RC00060,RC00557 ko00000,ko00001,ko01000 Bacteria 27XXT@189775,2G6HT@200795,COG0665@1,COG0665@2 NA|NA|NA E FAD dependent oxidoreductase MAG.T1.121_00314 479434.Sthe_2649 1.1e-212 746.5 Thermomicrobia ftsH GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0030163,GO:0042623,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 ko:K03798 M00742 ko00000,ko00002,ko01000,ko01002,ko03110 Bacteria 27XYF@189775,2G63X@200795,COG0465@1,COG0465@2 NA|NA|NA O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins MAG.T1.121_00315 1122223.KB890697_gene1218 5.4e-69 267.7 Deinococcus-Thermus 2.3.2.5 ko:K00683 ko00000,ko01000 Bacteria 1WM89@1297,COG3823@1,COG3823@2 NA|NA|NA M Glutamine cyclotransferase MAG.T1.121_00316 479434.Sthe_2121 9.2e-283 979.5 Chloroflexi MA20_17010 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2G7U8@200795,COG2609@1,COG2609@2 NA|NA|NA C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) MAG.T1.121_00317 485913.Krac_0465 8.2e-34 150.2 Bacteria Bacteria COG1853@1,COG1853@2 NA|NA|NA S FMN binding MAG.T1.121_00318 370438.PTH_0664 3.9e-125 454.9 Peptococcaceae amt ko:K03320 ko00000,ko02000 1.A.11 iHN637.CLJU_c42670,iYO844.BSU36510 Bacteria 1TQYG@1239,247W1@186801,2603A@186807,COG0004@1,COG0004@2 NA|NA|NA U TIGRFAM Ammonium transporter MAG.T1.121_00319 1382356.JQMP01000004_gene288 1.9e-161 576.6 Thermomicrobia Bacteria 27XK8@189775,2G6HI@200795,COG4745@1,COG4745@2 NA|NA|NA O Dolichyl-phosphate-mannose-protein mannosyltransferase MAG.T1.121_00320 479434.Sthe_1861 1.6e-39 171.8 Thermomicrobia Bacteria 27Y63@189775,2GB92@200795,COG1807@1,COG1807@2 NA|NA|NA M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family MAG.T1.121_00321 479434.Sthe_3297 4e-77 295.4 Thermomicrobia ko:K02055 ko02024,map02024 M00193 ko00000,ko00001,ko00002,ko02000 3.A.1.11 Bacteria 27YYF@189775,2GA36@200795,COG0687@1,COG0687@2 NA|NA|NA E Bacterial extracellular solute-binding protein MAG.T1.121_00322 479434.Sthe_1234 5.3e-100 371.7 Thermomicrobia Bacteria 27YXI@189775,2G7N8@200795,COG5476@1,COG5476@2 NA|NA|NA S MlrC C-terminus MAG.T1.121_00324 1122135.KB893146_gene1466 2.5e-35 155.6 Alphaproteobacteria yahN GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015318,GO:0015711,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1903825,GO:1905039 ko:K03329,ko:K16327 ko00000,ko02000 2.A.76.1.3,2.A.76.1.6 Bacteria 1N227@1224,2UCZW@28211,COG1280@1,COG1280@2 NA|NA|NA E lysine exporter protein (LysE YggA) MAG.T1.121_00325 1521187.JPIM01000075_gene2830 1.3e-198 699.9 Chloroflexia ppk 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 2G68J@200795,374Y0@32061,COG0855@1,COG0855@2 NA|NA|NA H Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) MAG.T1.121_00327 479434.Sthe_2878 2.2e-133 482.3 Chloroflexi ko:K01999 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 2G6Q1@200795,COG0683@1,COG0683@2 NA|NA|NA E PFAM Extracellular ligand-binding receptor MAG.T1.121_00328 479434.Sthe_2877 1.3e-83 316.2 Thermomicrobia ko:K01995,ko:K01998 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 27YUS@189775,2G5W6@200795,COG0411@1,COG0411@2 NA|NA|NA P Branched-chain amino acid ATP-binding cassette transporter MAG.T1.121_00329 479434.Sthe_2876 6.4e-70 270.8 Thermomicrobia ko:K01996 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 27Y8Q@189775,2G69M@200795,COG0410@1,COG0410@2 NA|NA|NA E PFAM ABC transporter related MAG.T1.121_00330 479434.Sthe_2875 1e-98 366.7 Thermomicrobia ko:K01997 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 27YIM@189775,2G6FM@200795,COG0559@1,COG0559@2 NA|NA|NA E Belongs to the binding-protein-dependent transport system permease family MAG.T1.121_00331 479434.Sthe_2874 1.1e-97 363.6 Chloroflexi ko:K01998 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 2G8PV@200795,COG4177@1,COG4177@2 NA|NA|NA U Branched-chain amino acid transport system / permease component MAG.T1.121_00332 479434.Sthe_2873 1.6e-172 612.5 Thermomicrobia gabT 2.6.1.19,5.1.1.21 ko:K00823,ko:K20708 ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 27XJH@189775,2G5SK@200795,COG0160@1,COG0160@2 NA|NA|NA H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family MAG.T1.121_00333 479434.Sthe_2872 1.4e-132 479.6 Thermomicrobia cpg2 3.4.17.11 ko:K01295 ko00000,ko01000,ko01002 Bacteria 27Y02@189775,2G60R@200795,COG0624@1,COG0624@2 NA|NA|NA E peptidase dimerisation domain protein MAG.T1.121_00334 1122223.KB890687_gene2826 1.8e-159 569.3 Bacteria appA ko:K02035 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria COG0747@1,COG0747@2 NA|NA|NA E dipeptide transport MAG.T1.121_00335 1120950.KB892756_gene6636 4.6e-105 388.3 Propionibacteriales Bacteria 2GKD7@201174,4DPZT@85009,COG0399@1,COG0399@2 NA|NA|NA M DegT/DnrJ/EryC1/StrS aminotransferase family MAG.T1.121_00336 1123242.JH636434_gene5495 1.6e-64 253.4 Planctomycetes Bacteria 2DZFF@1,2J38Y@203682,32V9C@2 NA|NA|NA MAG.T1.121_00337 1131269.AQVV01000004_gene596 1.4e-25 124.0 Bacteria Bacteria COG0673@1,COG0673@2 NA|NA|NA S inositol 2-dehydrogenase activity MAG.T1.121_00338 1297569.MESS2_760069 4.9e-27 128.6 Alphaproteobacteria 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 Bacteria 1NRV2@1224,2UPKT@28211,COG0329@1,COG0329@2 NA|NA|NA EM Belongs to the DapA family MAG.T1.121_00339 857293.CAAU_2203 3.5e-24 119.4 Clostridiaceae bplA 1.1.1.335 ko:K13020 ko00520,map00520 R10140 RC00182 ko00000,ko00001,ko01000,ko01005 Bacteria 1TP83@1239,248XQ@186801,36F4R@31979,COG0673@1,COG0673@2 NA|NA|NA S Oxidoreductase family, C-terminal alpha beta domain MAG.T1.121_00340 1123321.KB905814_gene2214 6.3e-83 315.1 Actinobacteria 3.5.1.81 ko:K06015 R02192 RC00064,RC00328 ko00000,ko01000 Bacteria 2GKMK@201174,COG3653@1,COG3653@2 NA|NA|NA Q N-acyl-D-aspartate D-glutamate deacylase MAG.T1.121_00341 1145276.T479_11425 5.5e-76 291.2 Lysinibacillus appC ko:K02034,ko:K15582,ko:K15586 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439,M00440 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 1TP4R@1239,3J02Y@400634,4HBB9@91061,COG1173@1,COG1173@2 NA|NA|NA P COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components MAG.T1.121_00342 986075.CathTA2_2613 1.1e-79 303.5 Bacilli oppB GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 ko:K02033 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 1TP1S@1239,4HATR@91061,COG0601@1,COG0601@2 NA|NA|NA P ABC-type dipeptide oligopeptide nickel transport systems, permease components MAG.T1.121_00343 1040987.AZUY01000056_gene5450 1.1e-53 218.0 Phyllobacteriaceae appA ko:K02035 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 1MY4R@1224,2U4GZ@28211,43PIW@69277,COG0747@1,COG0747@2 NA|NA|NA E Bacterial extracellular solute-binding proteins, family 5 Middle MAG.T1.121_00344 1028800.RG540_PA13890 5.5e-24 118.2 Rhizobiaceae ko:K05799 ko00000,ko03000 Bacteria 1R3Y8@1224,2U215@28211,4BBJ2@82115,COG2186@1,COG2186@2 NA|NA|NA K transcriptional regulator MAG.T1.121_00345 485913.Krac_10794 2.5e-216 758.4 Chloroflexi typA GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840 ko:K06207 ko00000 Bacteria 2G5NQ@200795,COG1217@1,COG1217@2 NA|NA|NA T elongation factor Tu domain 2 protein MAG.T1.121_00346 1123320.KB889697_gene9013 1.7e-124 453.0 Actinobacteria Bacteria 2GIZX@201174,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily MAG.T1.121_00347 1192034.CAP_1151 1.2e-06 60.8 Myxococcales ugpQ GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0008081,GO:0008889,GO:0016787,GO:0016788,GO:0042578,GO:0043167,GO:0043169,GO:0046872,GO:0047389,GO:0047395 3.1.4.46 ko:K01126 ko00564,map00564 R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 iEC042_1314.EC042_3710,iEC55989_1330.EC55989_3857 Bacteria 1MU8H@1224,2WQ9A@28221,2YVEF@29,42U7W@68525,COG0584@1,COG0584@2 NA|NA|NA C glycerophosphoryl diester phosphodiesterase MAG.T1.121_00348 1267535.KB906767_gene4291 1.1e-58 233.4 Acidobacteriia ko:K07025 ko00000 Bacteria 2JJ40@204432,3Y4BM@57723,COG1011@1,COG1011@2 NA|NA|NA S Haloacid dehalogenase-like hydrolase MAG.T1.121_00349 357808.RoseRS_3033 3.2e-106 392.1 Chloroflexia ycaQ ko:K09927 ko00000 Bacteria 2G82W@200795,3771W@32061,COG3214@1,COG3214@2 NA|NA|NA S Winged helix DNA-binding domain MAG.T1.121_00350 1382306.JNIM01000001_gene3776 4.6e-184 651.4 Chloroflexi ko:K06147,ko:K06148 ko00000,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 2G7QD@200795,COG1132@1,COG1132@2 NA|NA|NA P PFAM ABC transporter related MAG.T1.121_00351 525904.Tter_1479 3.8e-46 192.2 Bacteria 3.2.1.8 ko:K01181 ko00000,ko01000 Bacteria COG3693@1,COG3693@2 NA|NA|NA G endo-1,4-beta-xylanase activity MAG.T1.121_00353 1123242.JH636434_gene4744 8e-54 217.2 Bacteria ko:K07045 ko00000 Bacteria COG2159@1,COG2159@2 NA|NA|NA E amidohydrolase MAG.T1.121_00354 344747.PM8797T_16028 1.9e-36 160.2 Planctomycetes Bacteria 2J3X6@203682,COG4409@1,COG4409@2 NA|NA|NA G BNR repeat-like domain MAG.T1.121_00355 565033.GACE_0162 8.8e-17 94.4 Archaeoglobi Archaea 2469I@183980,2XSWE@28890,COG0613@1,arCOG00302@2157 NA|NA|NA S PFAM PHP domain MAG.T1.121_00356 1961.JOAK01000020_gene7349 6e-11 73.6 Actinobacteria Bacteria 2DNXR@1,2I2KW@201174,32ZPP@2 NA|NA|NA S Domain of unknown function (DUF1905) MAG.T1.121_00357 1380390.JIAT01000010_gene3733 5.9e-112 411.0 Actinobacteria oxdC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0033609,GO:0043436,GO:0043648,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0046564,GO:0071704 4.1.1.2 ko:K01569 ko00630,ko01100,map00630,map01100 R00522 RC00321 ko00000,ko00001,ko01000 iYO844.BSU18670 Bacteria 2GMY3@201174,COG2140@1,COG2140@2 NA|NA|NA G Cupin MAG.T1.121_00358 479434.Sthe_3486 3e-210 738.4 Thermomicrobia GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K07114 ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 Bacteria 27XPF@189775,2G8A6@200795,COG4867@1,COG4867@2 NA|NA|NA S von Willebrand factor (vWF) type A domain MAG.T1.121_00359 479434.Sthe_3485 3.6e-194 684.5 Thermomicrobia chlI 6.6.1.1 ko:K03405 ko00860,ko01100,ko01110,map00860,map01100,map01110 R03877 RC01012 ko00000,ko00001,ko01000 iNJ661.Rv0958 Bacteria 27XRK@189775,2GB7G@200795,COG1239@1,COG1239@2 NA|NA|NA H Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX MAG.T1.121_00360 311424.DhcVS_655 3.5e-52 212.2 Dehalococcoidia hpt GO:0000287,GO:0003674,GO:0003824,GO:0004422,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006166,GO:0006177,GO:0006188,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032261,GO:0032263,GO:0032264,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0043094,GO:0043101,GO:0043167,GO:0043169,GO:0043173,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 Bacteria 2G6HX@200795,34D91@301297,COG0634@1,COG0634@2,COG1102@1,COG1102@2,COG2203@1,COG2203@2 NA|NA|NA F Phosphoribosyl transferase domain MAG.T1.121_00361 1416752.AYME01000002_gene799 2.1e-108 399.1 Microbacteriaceae corA ko:K03284 ko00000,ko02000 1.A.35.1,1.A.35.3 Bacteria 2GKNZ@201174,4FK6E@85023,COG0598@1,COG0598@2 NA|NA|NA P Magnesium transport protein CorA MAG.T1.121_00362 479434.Sthe_2950 6.4e-193 680.2 Thermomicrobia trpB 4.2.1.20 ko:K01696,ko:K06001 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 Bacteria 27XSD@189775,2G5YY@200795,COG1350@1,COG1350@2 NA|NA|NA E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine MAG.T1.121_00363 1382356.JQMP01000004_gene130 6.4e-64 250.8 Thermomicrobia dedA ko:K03975 ko00000 Bacteria 27YWX@189775,2GBDA@200795,COG0586@1,COG0586@2 NA|NA|NA S SNARE associated Golgi protein MAG.T1.121_00364 1246995.AFR_29780 3.5e-19 102.4 Micromonosporales 3.2.2.21 ko:K01247 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 2IB0Q@201174,4DJTX@85008,COG0122@1,COG0122@2 NA|NA|NA L 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase MAG.T1.121_00365 511051.CSE_03850 2.5e-77 296.2 Bacteria ko:K15770,ko:K15771 ko02010,map02010 M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1.16,3.A.1.1.2 Bacteria COG2182@1,COG2182@2 NA|NA|NA G maltose binding MAG.T1.121_00366 511051.CSE_03860 5.6e-93 347.8 Bacteria malF ko:K02025,ko:K15770,ko:K15771 ko02010,map02010 M00207,M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.2 Bacteria COG1175@1,COG1175@2 NA|NA|NA P transmembrane transport MAG.T1.121_00367 511051.CSE_03870 7e-77 294.3 Bacteria malG ko:K15772 ko02010,map02010 M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1.16,3.A.1.1.2 Bacteria COG3833@1,COG3833@2 NA|NA|NA P maltose-transporting ATPase activity MAG.T1.121_00369 479434.Sthe_0416 1e-217 763.1 Thermomicrobia uvrC GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391 ko:K03703 ko03420,map03420 ko00000,ko00001,ko03400 Bacteria 27Y2A@189775,2G651@200795,COG0322@1,COG0322@2 NA|NA|NA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision MAG.T1.121_00370 479434.Sthe_0417 7.1e-42 177.6 Thermomicrobia prmC 2.7.7.87 ko:K07566 R10463 RC00745 ko00000,ko01000,ko03009,ko03016 Bacteria 27Y7A@189775,2G673@200795,COG0009@1,COG0009@2 NA|NA|NA J Telomere recombination MAG.T1.121_00371 479434.Sthe_0422 1.5e-26 127.1 Thermomicrobia Bacteria 27YKN@189775,2ETJ3@1,2G7IK@200795,33M2W@2 NA|NA|NA MAG.T1.121_00373 479434.Sthe_0425 3.1e-173 614.8 Thermomicrobia rarA ko:K07478 ko00000 Bacteria 27XS9@189775,2G5JC@200795,COG2256@1,COG2256@2 NA|NA|NA L MgsA AAA+ ATPase C terminal MAG.T1.121_00374 1123400.KB904747_gene486 6.7e-72 277.3 Thiotrichales rph GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006401,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043170,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:1901361,GO:1901575 2.7.7.56,3.6.1.66 ko:K00989,ko:K02428 ko00230,map00230 R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000,ko03016 Bacteria 1MVFZ@1224,1RNTB@1236,45ZZN@72273,COG0689@1,COG0689@2 NA|NA|NA J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates MAG.T1.121_00375 309801.trd_0435 1.6e-28 133.7 Thermomicrobia hisC 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 27XEN@189775,2G5U4@200795,COG0079@1,COG0079@2 NA|NA|NA E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily MAG.T1.121_00376 266779.Meso_2768 3.1e-40 172.2 Phyllobacteriaceae ko:K07096 ko00000 Bacteria 1MVNK@1224,2U1YV@28211,43P2G@69277,COG2129@1,COG2129@2 NA|NA|NA S Calcineurin-like phosphoesterase MAG.T1.121_00377 479434.Sthe_0435 3.3e-44 186.0 Thermomicrobia 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 ko00000,ko00001,ko01000,ko01002,ko01011 Bacteria 27Z58@189775,2G8TU@200795,COG1686@1,COG1686@2 NA|NA|NA M Belongs to the peptidase S11 family MAG.T1.121_00378 479434.Sthe_0436 9.1e-69 266.9 Thermomicrobia rluB 5.4.99.22 ko:K06178 ko00000,ko01000,ko03009 Bacteria 27XQ1@189775,2G6HU@200795,COG1187@1,COG1187@2 NA|NA|NA J Belongs to the pseudouridine synthase RsuA family MAG.T1.121_00379 877411.JMMA01000002_gene2231 3.1e-55 223.0 Ruminococcaceae cmk GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.3.1.51,2.5.1.19,2.7.4.25,6.3.2.1 ko:K00655,ko:K00800,ko:K00945,ko:K03977,ko:K13799 ko00240,ko00400,ko00410,ko00561,ko00564,ko00770,ko01100,ko01110,ko01130,ko01230,map00240,map00400,map00410,map00561,map00564,map00770,map01100,map01110,map01130,map01230 M00022,M00052,M00089,M00119 R00158,R00512,R01665,R02241,R02473,R03460,R09381 RC00002,RC00004,RC00037,RC00039,RC00096,RC00141,RC00350 ko00000,ko00001,ko00002,ko01000,ko01004,ko03009 Bacteria 1V3IA@1239,24HEF@186801,3WIDU@541000,COG0204@1,COG0204@2,COG0283@1,COG0283@2 NA|NA|NA F Belongs to the cytidylate kinase family. Type 1 subfamily MAG.T1.121_00380 479434.Sthe_0730 4.5e-136 491.5 Thermomicrobia obg GO:0000003,GO:0000160,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019954,GO:0023052,GO:0030436,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035556,GO:0035639,GO:0036094,GO:0043021,GO:0043022,GO:0043167,GO:0043168,GO:0043934,GO:0044424,GO:0044464,GO:0044877,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0097159,GO:0097367,GO:1901265,GO:1901363 ko:K03979 ko00000,ko01000,ko03009 Bacteria 27XUD@189775,2G5ZT@200795,COG0536@1,COG0536@2 NA|NA|NA S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control MAG.T1.121_00381 479434.Sthe_0729 2.3e-132 479.2 Thermomicrobia sigA GO:0000988,GO:0000990,GO:0001098,GO:0001101,GO:0001108,GO:0001666,GO:0002791,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006950,GO:0008150,GO:0009266,GO:0009405,GO:0009408,GO:0009410,GO:0009415,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010035,GO:0010468,GO:0010556,GO:0010557,GO:0010565,GO:0010604,GO:0010628,GO:0016020,GO:0016987,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0019899,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032879,GO:0032880,GO:0036293,GO:0040007,GO:0042221,GO:0043175,GO:0043254,GO:0044087,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050708,GO:0050789,GO:0050794,GO:0050896,GO:0051046,GO:0051049,GO:0051128,GO:0051171,GO:0051173,GO:0051223,GO:0051252,GO:0051254,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0070063,GO:0070201,GO:0070482,GO:0071944,GO:0080090,GO:0090087,GO:0097159,GO:0140110,GO:1901363,GO:1901700,GO:1902680,GO:1903506,GO:1903508,GO:1903530,GO:2000112,GO:2000142,GO:2001141 ko:K03086,ko:K03087 ko02026,ko05111,map02026,map05111 ko00000,ko00001,ko03021 Bacteria 27XEZ@189775,2G5W3@200795,COG0568@1,COG0568@2 NA|NA|NA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth MAG.T1.121_00382 479434.Sthe_0728 3.7e-121 441.8 Thermomicrobia lysA 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 Bacteria 27XZ6@189775,2G5RR@200795,COG0019@1,COG0019@2 NA|NA|NA E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine MAG.T1.121_00383 479434.Sthe_0727 1.4e-185 656.4 Thermomicrobia ko:K06158 ko00000,ko03012 Bacteria 27XQY@189775,2G5VD@200795,COG0488@1,COG0488@2 NA|NA|NA S ABC transporter MAG.T1.121_00384 309801.trd_1716 1.7e-49 202.6 Thermomicrobia coaE GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24,2.7.7.87 ko:K00859,ko:K07566 ko00770,ko01100,map00770,map01100 M00120 R00130,R10463 RC00002,RC00078,RC00745 ko00000,ko00001,ko00002,ko01000,ko03009,ko03016 Bacteria 27Y6K@189775,2G6RQ@200795,COG0237@1,COG0237@2 NA|NA|NA H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A MAG.T1.121_00385 1382356.JQMP01000004_gene610 8.8e-41 173.7 Chloroflexi yjbH GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 Bacteria 2G9IQ@200795,COG2761@1,COG2761@2 NA|NA|NA Q DSBA-like thioredoxin domain MAG.T1.121_00386 479434.Sthe_3260 5.2e-98 364.4 Thermomicrobia mutY GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:1901360 2.1.1.37,2.1.3.15,6.4.1.2 ko:K00558,ko:K01962,ko:K01963,ko:K03575 ko00061,ko00270,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko03410,ko05206,map00061,map00270,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212,map03410,map05206 M00035,M00082,M00376 R00742,R04386,R04858 RC00003,RC00040,RC00253,RC00332,RC00367 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036,ko03400 Bacteria 27XJQ@189775,2G62P@200795,COG1194@1,COG1194@2 NA|NA|NA L FES MAG.T1.121_00387 266940.Krad_1129 3.6e-36 158.7 Actinobacteria Bacteria 2I3JK@201174,COG3415@1,COG3415@2 NA|NA|NA L Protein of unknown function (DUF3105) MAG.T1.121_00388 1382356.JQMP01000003_gene2141 4.2e-176 624.4 Thermomicrobia glyQS GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009345,GO:0009987,GO:0010467,GO:0016070,GO:0016594,GO:0016597,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0042165,GO:0042802,GO:0042803,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046983,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.14 ko:K01880 ko00970,map00970 M00359,M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 iSB619.SA_RS07880 Bacteria 27XGU@189775,2G62M@200795,COG0423@1,COG0423@2 NA|NA|NA J Catalyzes the attachment of glycine to tRNA(Gly) MAG.T1.121_00389 309801.trd_1055 5.7e-71 274.6 Thermomicrobia xerD ko:K04763 ko00000,ko03036 Bacteria 27Y19@189775,2G6CI@200795,COG4974@1,COG4974@2 NA|NA|NA L Belongs to the 'phage' integrase family MAG.T1.121_00390 1382356.JQMP01000003_gene2139 3.6e-128 464.9 Thermomicrobia ald GO:0000286,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009653,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0019752,GO:0030154,GO:0030435,GO:0032502,GO:0043436,GO:0043934,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0048646,GO:0048856,GO:0048869,GO:0055114,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 R00396 RC00008 ko00000,ko00001,ko01000 iAF987.Gmet_1099 Bacteria 27YU4@189775,2G68X@200795,COG0686@1,COG0686@2 NA|NA|NA C Alanine dehydrogenase/PNT, N-terminal domain MAG.T1.121_00392 234267.Acid_7899 1.6e-191 676.0 Acidobacteria clcA_1 ko:K03281 ko00000 2.A.49 Bacteria 3Y2I6@57723,COG0038@1,COG0038@2,COG0517@1,COG0517@2 NA|NA|NA P Voltage gated chloride channel MAG.T1.121_00395 479434.Sthe_1174 7.2e-127 461.8 Thermomicrobia Bacteria 27Y0P@189775,2G5UJ@200795,COG1807@1,COG1807@2,COG5427@1,COG5427@2 NA|NA|NA M Uncharacterized membrane protein (DUF2298) MAG.T1.121_00396 1158146.KB907123_gene745 7.2e-69 267.7 Chromatiales fmt GO:0003674,GO:0003824,GO:0004479,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006418,GO:0006431,GO:0006464,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019752,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.1.176,2.1.2.9 ko:K00604,ko:K03500 ko00670,ko00970,map00670,map00970 R03940 RC00026,RC00165 ko00000,ko00001,ko01000,ko03009 iECABU_c1320.ECABU_c37050,iECUMN_1333.ECUMN_3761,ic_1306.c4048 Bacteria 1MU4Q@1224,1RP1T@1236,1WWQE@135613,COG0223@1,COG0223@2 NA|NA|NA J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus MAG.T1.121_00398 1382356.JQMP01000003_gene2345 2.1e-95 355.9 Thermomicrobia tyrA 1.3.1.12,1.3.1.43 ko:K00210,ko:K00220,ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025,M00040 R00732,R01728 RC00125 ko00000,ko00001,ko00002,ko01000 Bacteria 27XQX@189775,2G6BW@200795,COG0287@1,COG0287@2 NA|NA|NA C Prephenate dehydrogenase MAG.T1.121_00399 479434.Sthe_0804 9.3e-18 97.1 Thermomicrobia ygiM ko:K07184 ko00000 Bacteria 27YJC@189775,2GBAP@200795,COG3807@1,COG3807@2 NA|NA|NA S Bacterial SH3 domain MAG.T1.121_00400 479434.Sthe_1236 2.9e-94 352.1 Thermomicrobia rapL 4.3.1.12 ko:K01750 ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230 R00671 RC00354 ko00000,ko00001,ko01000 Bacteria 27XIZ@189775,2G6BQ@200795,COG2423@1,COG2423@2 NA|NA|NA E Ornithine cyclodeaminase/mu-crystallin family MAG.T1.121_00401 479434.Sthe_1238 1.2e-191 676.4 Thermomicrobia 1.12.1.3,1.6.5.3 ko:K00335,ko:K18331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 27Y30@189775,2G5K9@200795,COG1894@1,COG1894@2 NA|NA|NA C NADH-ubiquinone oxidoreductase-F iron-sulfur binding region MAG.T1.121_00402 479434.Sthe_1239 3.8e-40 171.4 Thermomicrobia 1.6.5.3 ko:K00127,ko:K00334 ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200 M00144 R00519,R11945 RC00061,RC02796 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 27Y9K@189775,2G6Q5@200795,COG1905@1,COG1905@2 NA|NA|NA C Thioredoxin-like [2Fe-2S] ferredoxin MAG.T1.121_00403 479434.Sthe_1243 6e-14 84.0 Thermomicrobia Bacteria 27YRH@189775,2A4SM@1,2GA2B@200795,30TE1@2 NA|NA|NA MAG.T1.121_00404 1382356.JQMP01000003_gene2514 3.5e-49 201.4 Thermomicrobia GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 ko:K03617,ko:K08999 ko00000 Bacteria 27Y7W@189775,2G6P6@200795,COG1259@1,COG1259@2 NA|NA|NA S Bifunctional nuclease MAG.T1.121_00405 479434.Sthe_1245 2.4e-48 199.1 Thermomicrobia lepB 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 ko00000,ko00001,ko01000,ko01002 Bacteria 27Y6Z@189775,2G701@200795,COG0681@1,COG0681@2 NA|NA|NA U Belongs to the peptidase S26 family MAG.T1.121_00406 479434.Sthe_1248 2.7e-11 74.3 Thermomicrobia tatA ko:K03116 ko03060,ko03070,map03060,map03070 M00336 ko00000,ko00001,ko00002,ko02044 2.A.64 Bacteria 27YQN@189775,2GAXB@200795,COG1826@1,COG1826@2 NA|NA|NA U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system MAG.T1.121_00408 479434.Sthe_1226 3.6e-116 425.6 Thermomicrobia Bacteria 27XRE@189775,2G82N@200795,COG3170@1,COG3170@2 NA|NA|NA NU Tfp pilus assembly protein FimV MAG.T1.121_00409 1382356.JQMP01000001_gene988 1.1e-26 127.5 Thermomicrobia Bacteria 27Y7K@189775,2G6MW@200795,COG1413@1,COG1413@2 NA|NA|NA C PBS lyase HEAT-like repeat MAG.T1.121_00410 1382356.JQMP01000001_gene989 3e-47 195.7 Thermomicrobia murM 2.3.2.10,2.3.2.16,2.3.2.17,2.3.2.18 ko:K05363,ko:K11693,ko:K11694,ko:K11695,ko:K12554,ko:K18354 ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020 M00651 R08776,R08777,R08778,R08779,R08780 RC00055,RC00064,RC00096 ko00000,ko00001,ko00002,ko01000,ko01011,ko01504 Bacteria 27Z2Y@189775,2G6KK@200795,COG2348@1,COG2348@2 NA|NA|NA V Acetyltransferase (GNAT) domain MAG.T1.121_00411 479434.Sthe_1224 9.7e-142 510.4 Thermomicrobia murE 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 Bacteria 27Y4T@189775,2G5U3@200795,COG0769@1,COG0769@2 NA|NA|NA M Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan MAG.T1.121_00412 1521187.JPIM01000035_gene3399 2.6e-197 695.3 Chloroflexia aspS 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 Bacteria 2G5RX@200795,374WK@32061,COG0173@1,COG0173@2 NA|NA|NA J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) MAG.T1.121_00413 1274374.CBLK010000086_gene4606 6.4e-34 151.4 Paenibacillaceae mazG GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.6.1.66,3.6.1.9 ko:K02428,ko:K02499,ko:K04765 ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100 R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R01855,R02100,R02720,R03004,R03036,R03531,R11323 RC00002 ko00000,ko00001,ko01000,ko03036 iJN678.sll1005 Bacteria 1TPK1@1239,26QBT@186822,4HA0A@91061,COG1694@1,COG3956@2 NA|NA|NA S Protein containing tetrapyrrole methyltransferase domain and MazG-like MAG.T1.121_00414 479434.Sthe_1219 6.8e-262 909.8 Thermomicrobia lepA GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 ko:K03596 ko05134,map05134 ko00000,ko00001 Bacteria 27XM4@189775,2G5K2@200795,COG0481@1,COG0481@2 NA|NA|NA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner MAG.T1.121_00415 479434.Sthe_1218 7.8e-139 501.1 Thermomicrobia murJ ko:K03980 ko00000,ko01011,ko02000 2.A.66.4 Bacteria 27XGY@189775,2G5MD@200795,COG0728@1,COG0728@2 NA|NA|NA S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane MAG.T1.121_00416 479434.Sthe_1214 5.4e-25 122.1 Thermomicrobia holA GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 27YH1@189775,2GBAA@200795,COG1466@1,COG1466@2 NA|NA|NA L dna polymerase III delta subunit MAG.T1.121_00417 1304880.JAGB01000001_gene34 1.9e-127 462.6 Clostridia fabF 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 1TPA7@1239,247VF@186801,COG0304@1,COG0304@2 NA|NA|NA I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP MAG.T1.121_00418 479434.Sthe_1210 1.3e-143 516.2 Thermomicrobia ko:K03086 ko00000,ko03021 Bacteria 27Y4V@189775,2G5W3@200795,COG0568@1,COG0568@2 NA|NA|NA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth MAG.T1.121_00419 765420.OSCT_0708 6.6e-67 260.8 Chloroflexia yebC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 Bacteria 2G6AI@200795,375BW@32061,COG0217@1,COG0217@2 NA|NA|NA K transcriptional regulatory protein MAG.T1.121_00420 479434.Sthe_1209 1.5e-46 192.6 Thermomicrobia ruvC GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 ko:K01159 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 27YFU@189775,2G6MA@200795,COG0817@1,COG0817@2 NA|NA|NA L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group MAG.T1.121_00421 479434.Sthe_1208 7.5e-69 267.3 Thermomicrobia tlyA GO:0000154,GO:0001510,GO:0001897,GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019835,GO:0019836,GO:0022613,GO:0031167,GO:0031640,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035821,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044003,GO:0044004,GO:0044085,GO:0044179,GO:0044237,GO:0044238,GO:0044260,GO:0044364,GO:0044403,GO:0044419,GO:0044764,GO:0046483,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.226,2.1.1.227 ko:K06442 ko00000,ko01000,ko03009 Bacteria 27XW2@189775,2G6BX@200795,COG1189@1,COG1189@2 NA|NA|NA J FtsJ-like methyltransferase MAG.T1.121_00422 1128421.JAGA01000002_gene1225 3.3e-58 231.9 unclassified Bacteria cpmA ko:K06898 ko00000 Bacteria 2NPQT@2323,COG1691@1,COG1691@2 NA|NA|NA S AIR carboxylase MAG.T1.121_00423 1382306.JNIM01000001_gene378 3.2e-66 258.8 Chloroflexi ko:K07588 ko00000,ko01000 Bacteria 2G670@200795,COG1703@1,COG1703@2 NA|NA|NA E TIGRFAM LAO AO transport system ATPase MAG.T1.121_00424 479434.Sthe_1206 1.3e-46 192.6 Thermomicrobia icmB 5.4.99.2,5.4.99.64 ko:K01849,ko:K20907 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 Bacteria 27YE6@189775,2G6S9@200795,COG2185@1,COG2185@2 NA|NA|NA I B12 binding domain MAG.T1.121_00425 479434.Sthe_1202 2.8e-85 322.0 Chloroflexi hbdA 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 Bacteria 2G6EB@200795,COG1250@1,COG1250@2 NA|NA|NA C 3-hydroxyacyl-CoA dehydrogenase domain protein MAG.T1.121_00426 349161.Dred_0109 9.4e-48 196.8 Peptococcaceae pth GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016787,GO:0016788,GO:0040007,GO:0044464,GO:0052689,GO:0071944,GO:0140098,GO:0140101 3.1.1.29 ko:K01056 ko00000,ko01000,ko03012 Bacteria 1V3NB@1239,24HMC@186801,261YC@186807,COG0193@1,COG0193@2 NA|NA|NA J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis MAG.T1.121_00427 479434.Sthe_1198 2.3e-07 62.8 Thermomicrobia tatA ko:K03116,ko:K03117,ko:K03646 ko03060,ko03070,map03060,map03070 M00336 ko00000,ko00001,ko00002,ko02000,ko02044 2.A.64,2.C.1.2 Bacteria 27YMK@189775,2G7D4@200795,COG1826@1,COG1826@2 NA|NA|NA U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system MAG.T1.121_00428 1382356.JQMP01000003_gene2540 1.8e-117 429.5 Thermomicrobia tgt GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0008479,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.29 ko:K00773 R03789,R10209 RC00063 ko00000,ko01000,ko03016 iECW_1372.ECW_m0475,iWFL_1372.ECW_m0475 Bacteria 27XPV@189775,2G5RE@200795,COG0343@1,COG0343@2 NA|NA|NA J Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) MAG.T1.121_00429 1382356.JQMP01000003_gene2543 3.7e-35 154.5 Thermomicrobia acpS 2.7.8.7,4.3.1.14 ko:K00997,ko:K18014 ko00310,ko00770,map00310,map00770 R01625,R03030 RC00002,RC00833 ko00000,ko00001,ko01000 Bacteria 27YDS@189775,2G73N@200795,COG0736@1,COG0736@2 NA|NA|NA I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein MAG.T1.121_00430 479434.Sthe_1191 1.7e-54 219.9 Thermomicrobia nnrD GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0052855,GO:0052856,GO:0052857 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 ko00000,ko01000 Bacteria 27XV2@189775,2G5Y8@200795,COG0062@1,COG0062@2,COG0063@1,COG0063@2 NA|NA|NA H Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration MAG.T1.121_00431 479434.Sthe_1190 4.7e-19 101.3 Chloroflexi ko:K04767,ko:K07182 ko00000 Bacteria 2G8Z8@200795,COG0517@1,COG0517@2 NA|NA|NA E CBS domain MAG.T1.121_00432 1121468.AUBR01000001_gene578 1.8e-71 276.6 Thermoanaerobacterales alr 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 R00401 RC00285 ko00000,ko00001,ko01000,ko01011 Bacteria 1TNYY@1239,2480T@186801,42EZ0@68295,COG0787@1,COG0787@2 NA|NA|NA M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids MAG.T1.121_00433 479434.Sthe_1189 7.8e-62 243.4 Thermomicrobia Bacteria 27YBA@189775,2BPWQ@1,2GAA8@200795,32IQE@2 NA|NA|NA MAG.T1.121_00434 316274.Haur_2376 8.2e-23 113.2 Chloroflexi Bacteria 2EM6G@1,2G9RV@200795,33EVQ@2 NA|NA|NA MAG.T1.121_00435 479434.Sthe_1186 3.3e-43 182.2 Thermomicrobia Bacteria 27YCU@189775,2G711@200795,COG1235@1,COG1235@2 NA|NA|NA S Metallo-beta-lactamase superfamily MAG.T1.121_00436 309801.trd_0819 2.7e-54 218.8 Thermomicrobia yggS GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 ko:K06997 ko00000 Bacteria 27YGC@189775,2G6F1@200795,COG0325@1,COG0325@2 NA|NA|NA S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis MAG.T1.121_00437 1485543.JMME01000002_gene1633 6e-42 177.9 Negativicutes yfiH GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016679,GO:0016682,GO:0030312,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0046983,GO:0055114,GO:0071944 ko:K05810 ko00000,ko01000 Bacteria 1TS34@1239,4H26Q@909932,COG1496@1,COG1496@2 NA|NA|NA S Belongs to the multicopper oxidase YfiH RL5 family MAG.T1.121_00438 1382306.JNIM01000001_gene232 2.6e-124 452.6 Chloroflexi Bacteria 2G5YS@200795,COG4262@1,COG4262@2 NA|NA|NA S Spermine/spermidine synthase domain MAG.T1.121_00439 479434.Sthe_0798 1.4e-39 169.5 Thermomicrobia 2.7.7.53,3.6.1.13,3.6.1.67 ko:K01515,ko:K08310,ko:K19710 ko00230,ko00790,map00230,map00790 M00126 R00126,R01054,R01618,R04638 RC00002,RC02753,RC02795 ko00000,ko00001,ko00002,ko01000 Bacteria 27YBS@189775,2GB9J@200795,COG0494@1,COG0494@2 NA|NA|NA L NUDIX domain MAG.T1.121_00440 479434.Sthe_0796 7.9e-288 996.1 Thermomicrobia uvrB ko:K03702,ko:K08999 ko03420,map03420 ko00000,ko00001,ko03400 Bacteria 27XME@189775,2G5SU@200795,COG0556@1,COG0556@2 NA|NA|NA L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage MAG.T1.121_00441 479434.Sthe_0795 4.8e-41 175.3 Thermomicrobia Bacteria 27YBB@189775,2BQJQ@1,2GA0E@200795,32JFR@2 NA|NA|NA MAG.T1.121_00442 760117.JN27_17110 4.4e-42 177.6 Betaproteobacteria aroQ GO:0003674,GO:0003824,GO:0003855,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 3.4.13.9,4.2.1.10 ko:K01271,ko:K03785,ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000,ko01002 iIT341.HP1038,iJN746.PP_0560 Bacteria 1RDDT@1224,2VR4Y@28216,COG0757@1,COG0757@2 NA|NA|NA E Catalyzes a trans-dehydration via an enolate intermediate MAG.T1.121_00443 479434.Sthe_0792 5.4e-78 298.1 Thermomicrobia pepP GO:0003674,GO:0003824,GO:0004177,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.11.9,3.4.13.9 ko:K01262,ko:K01271,ko:K08326 ko00000,ko01000,ko01002 Bacteria 27XYM@189775,2G6AE@200795,COG0006@1,COG0006@2 NA|NA|NA E Belongs to the peptidase M24B family MAG.T1.121_00444 1382356.JQMP01000003_gene2334 1e-56 226.5 Thermomicrobia efp GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02356 ko00000,ko03012 Bacteria 27Y78@189775,2G6PY@200795,COG0231@1,COG0231@2 NA|NA|NA J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase MAG.T1.121_00445 330214.NIDE2468 3.3e-24 118.2 Nitrospirae accB 2.3.1.12,4.1.1.3,6.4.1.1 ko:K00627,ko:K01571,ko:K01960,ko:K02160 ko00010,ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko01230,map00010,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212,map01230 M00082,M00173,M00307,M00376,M00620 R00209,R00217,R00344,R00742,R02569 RC00004,RC00040,RC00367,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000,ko02000 3.B.1.1.1 Bacteria 3J0PI@40117,COG0511@1,COG0511@2 NA|NA|NA I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA MAG.T1.121_00446 479434.Sthe_0789 1.4e-79 303.5 Thermomicrobia xseA GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494 3.1.11.6,3.4.21.102 ko:K03601,ko:K03797 ko03430,map03430 ko00000,ko00001,ko01000,ko01002,ko03400 Bacteria 27XEW@189775,2G5M3@200795,COG1570@1,COG1570@2 NA|NA|NA L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides MAG.T1.121_00447 1177179.A11A3_00315 3.7e-07 60.8 Oceanospirillales xseB GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494 3.1.11.6 ko:K03602 ko03430,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 1N72V@1224,1SC7N@1236,1XM23@135619,COG1722@1,COG1722@2 NA|NA|NA L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides MAG.T1.121_00448 479434.Sthe_1344 6.9e-83 314.3 Thermomicrobia hypE ko:K04655 ko00000 Bacteria 27XEQ@189775,2G8E4@200795,COG0309@1,COG0309@2 NA|NA|NA O AIR synthase related protein, C-terminal domain MAG.T1.121_00449 1128421.JAGA01000002_gene1664 2.3e-77 295.8 unclassified Bacteria aspG GO:0005575,GO:0005623,GO:0042597,GO:0044464 3.4.19.5,3.5.1.1,3.5.1.26 ko:K01424,ko:K01444,ko:K13051 ko00250,ko00460,ko00511,ko01100,ko01110,ko04142,map00250,map00460,map00511,map01100,map01110,map04142 R00485 RC00010,RC02798 ko00000,ko00001,ko01000,ko01002 Bacteria 2NPFC@2323,COG1446@1,COG1446@2 NA|NA|NA E Asparaginase MAG.T1.121_00450 1229203.KI301992_gene1981 1.1e-87 330.5 Actinobacteria Bacteria 2GK0T@201174,COG3214@1,COG3214@2 NA|NA|NA S Winged helix DNA-binding domain MAG.T1.121_00451 479434.Sthe_1003 2.3e-199 701.8 Thermomicrobia rho ko:K03628 ko03018,map03018 ko00000,ko00001,ko03019,ko03021 Bacteria 27Y0Z@189775,2G5UQ@200795,COG1158@1,COG1158@2 NA|NA|NA K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template MAG.T1.121_00452 479434.Sthe_1002 3.1e-112 411.8 Thermomicrobia glpX 3.1.3.11,3.1.3.37 ko:K02446,ko:K11532 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00165,M00167 R00762,R01845,R04780 RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 27XXS@189775,2G5XR@200795,COG1494@1,COG1494@2 NA|NA|NA G Bacterial fructose-1,6-bisphosphatase, glpX-encoded MAG.T1.121_00453 479434.Sthe_1001 8.8e-146 524.6 Thermomicrobia dinG GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0045004,GO:0045005,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7,3.6.4.12 ko:K02342,ko:K03722 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 27XGW@189775,2G5P4@200795,COG1199@1,COG1199@2,COG2176@1,COG2176@2 NA|NA|NA L HELICc2 MAG.T1.121_00454 479434.Sthe_1000 9.7e-89 334.0 Thermomicrobia Bacteria 27Y1X@189775,2G63E@200795,COG0624@1,COG0624@2 NA|NA|NA E Peptidase family M28 MAG.T1.121_00455 479434.Sthe_0997 3.1e-232 811.2 Thermomicrobia sdhA GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0043436,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071704,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0072350,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 iE2348C_1286.E2348C_0603,iJN746.PP_4191,iPC815.YPO1111 Bacteria 27XUB@189775,2G5YB@200795,COG1053@1,COG1053@2 NA|NA|NA C Fumarate reductase flavoprotein C-term MAG.T1.121_00458 398767.Glov_0655 2.2e-76 292.4 Deltaproteobacteria ygdQ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 1MWC9@1224,2WKV4@28221,42MZB@68525,COG0861@1,COG0861@2 NA|NA|NA P PFAM Integral membrane protein TerC MAG.T1.121_00460 479434.Sthe_1212 1.8e-99 369.4 Thermomicrobia gyaR 1.1.1.26 ko:K00015 ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120 R00717,R01388 RC00031,RC00042 ko00000,ko00001,ko01000 Bacteria 27XH1@189775,2G5K0@200795,COG1052@1,COG1052@2 NA|NA|NA C D-isomer specific 2-hydroxyacid dehydrogenase MAG.T1.121_00461 375286.mma_2411 4.3e-130 471.9 Oxalobacteraceae ko:K03321 ko00000,ko02000 2.A.53.3 Bacteria 1MWDF@1224,2VHKJ@28216,474CI@75682,COG0659@1,COG0659@2 NA|NA|NA U Sulfate permease family MAG.T1.121_00462 1283299.AUKG01000002_gene4544 6.5e-102 378.3 Rubrobacteria hvsT ko:K03321 ko00000,ko02000 2.A.53.3 Bacteria 2GJCB@201174,4CPPW@84995,COG0659@1,COG0659@2 NA|NA|NA P sulphate transporter MAG.T1.121_00464 1120960.ATXG01000001_gene767 0.0 1238.0 Actinobacteria 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 Bacteria 2GJ8H@201174,COG3119@1,COG3119@2 NA|NA|NA P Pfam Sulfatase MAG.T1.121_00466 1382306.JNIM01000001_gene3379 1.8e-119 436.8 Bacteria Bacteria COG0493@1,COG0493@2 NA|NA|NA C 'glutamate synthase MAG.T1.121_00467 1157943.KB892705_gene2336 9.6e-88 331.6 Mycobacteriaceae 2.7.11.1 ko:K08282 ko00000,ko01000 Bacteria 233DM@1762,2GIZ1@201174,COG0515@1,COG0515@2,COG3903@1,COG3903@2 NA|NA|NA K involved in signal transduction (via phosphorylation) involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites catalytic activity ATP a protein ADP a phosphoprotein MAG.T1.121_00468 479434.Sthe_1882 4.8e-47 194.9 Chloroflexi Bacteria 2G93M@200795,COG4758@1,COG4758@2 NA|NA|NA S membrane MAG.T1.121_00469 1250232.JQNJ01000001_gene359 1.1e-22 114.4 Bacteria Bacteria COG3693@1,COG3693@2 NA|NA|NA G endo-1,4-beta-xylanase activity MAG.T1.121_00470 469383.Cwoe_3901 4.1e-79 301.6 Actinobacteria 3.5.1.104 ko:K22278 ko00000,ko01000 Bacteria 2GM0X@201174,COG0726@1,COG0726@2 NA|NA|NA G polysaccharide deacetylase MAG.T1.121_00471 479434.Sthe_0767 8e-48 196.4 Thermomicrobia erpA GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009061,GO:0009987,GO:0010467,GO:0015980,GO:0016020,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055114,GO:0071704,GO:0071840,GO:0071944,GO:1901564 ko:K13628,ko:K15724 ko00000,ko03016 Bacteria 27YEW@189775,2G705@200795,COG0316@1,COG0316@2 NA|NA|NA S Belongs to the HesB IscA family MAG.T1.121_00472 479434.Sthe_1849 4e-107 394.8 Thermomicrobia ko:K03086 ko00000,ko03021 Bacteria 27Y3K@189775,2G5W3@200795,COG0568@1,COG0568@2 NA|NA|NA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released MAG.T1.121_00473 479434.Sthe_1848 3.3e-109 402.1 Thermomicrobia tlyC ko:K03699 ko00000,ko02042 Bacteria 27YYU@189775,2G6DE@200795,COG1253@1,COG1253@2 NA|NA|NA S Transporter associated domain MAG.T1.121_00474 1158050.KB895456_gene2025 7.3e-15 88.6 Bacteria 1.7.2.1 ko:K00368 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 Bacteria COG3794@1,COG3794@2 NA|NA|NA C PFAM blue (type 1) copper domain protein MAG.T1.121_00475 1121091.AUMP01000057_gene1318 9.3e-70 271.2 Bacilli Bacteria 1TQJK@1239,4IRUW@91061,COG2132@1,COG2132@2 NA|NA|NA Q Multicopper oxidase MAG.T1.121_00476 1158050.KB895456_gene2025 1e-21 111.3 Bacteria 1.7.2.1 ko:K00368 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 Bacteria COG3794@1,COG3794@2 NA|NA|NA C PFAM blue (type 1) copper domain protein MAG.T1.121_00477 765420.OSCT_0862 6.6e-113 414.1 Chloroflexia 5.1.3.10,5.1.3.2 ko:K01784,ko:K12454 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984,R04266 RC00289,RC00528 ko00000,ko00001,ko00002,ko01000 Bacteria 2G6ET@200795,375HU@32061,COG0451@1,COG0451@2 NA|NA|NA M short-chain dehydrogenase reductase SDR MAG.T1.121_00478 1128421.JAGA01000002_gene800 3.9e-114 418.3 Bacteria Bacteria COG0438@1,COG0438@2 NA|NA|NA M transferase activity, transferring glycosyl groups MAG.T1.121_00479 1128421.JAGA01000002_gene799 1.4e-86 326.2 Bacteria Bacteria COG0500@1,COG2226@2 NA|NA|NA Q methyltransferase MAG.T1.121_00480 357808.RoseRS_0659 2.5e-225 789.6 Chloroflexia Bacteria 2G5UJ@200795,37551@32061,COG0457@1,COG0457@2,COG5427@1,COG5427@2 NA|NA|NA M Tetratricopeptide TPR_2 repeat protein MAG.T1.121_00481 1454004.AW11_01334 8.6e-122 443.7 Betaproteobacteria eryK Bacteria 1MY5H@1224,2VM7E@28216,COG2124@1,COG2124@2 NA|NA|NA C PFAM Cytochrome P450 MAG.T1.121_00482 479434.Sthe_2684 2.9e-65 256.1 Chloroflexi Bacteria 2G8W5@200795,COG0477@1,COG2814@2 NA|NA|NA EGP Major Facilitator Superfamily MAG.T1.121_00483 101510.RHA1_ro00788 6.6e-81 308.9 Nocardiaceae 2.7.11.1 ko:K08282 ko00000,ko01000 Bacteria 2GIZ1@201174,4FUTU@85025,COG2197@1,COG2197@2,COG3903@1,COG3903@2 NA|NA|NA K activity, protein serine threonine kinase activity, protein-tyrosine kinase activity, ATP binding, regulation of transcription, DNA-dependent, protein amino acid phosphorylation MAG.T1.121_00484 479434.Sthe_2097 6.5e-103 380.6 Chloroflexi ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2G6HN@200795,COG1131@1,COG1131@2 NA|NA|NA V PFAM ABC transporter related MAG.T1.121_00485 479434.Sthe_2098 2.9e-63 249.2 Chloroflexi ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GA92@200795,COG1668@1,COG1668@2 NA|NA|NA V ABC-2 family transporter protein MAG.T1.121_00486 684949.ATTJ01000002_gene202 1.6e-104 386.3 Bacteria argE 3.5.1.16 ko:K01438 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R00669,R09107 RC00064,RC00300 ko00000,ko00001,ko00002,ko01000 Bacteria COG0624@1,COG0624@2 NA|NA|NA E succinyl-diaminopimelate desuccinylase activity MAG.T1.121_00487 1382306.JNIM01000001_gene2984 1.9e-77 296.6 Bacteria Bacteria COG2211@1,COG2211@2 NA|NA|NA G Major facilitator Superfamily MAG.T1.121_00488 574375.BAGA_26710 1.2e-20 107.5 Bacillus yihY ko:K07058 ko00000 Bacteria 1U7HM@1239,1ZCAD@1386,4H9MJ@91061,COG1295@1,COG1295@2 NA|NA|NA S Belongs to the UPF0761 family MAG.T1.121_00489 1538295.JY96_17835 7.8e-08 65.1 Bacteria Bacteria COG5563@1,COG5563@2 NA|NA|NA MAG.T1.121_00490 1403819.BATR01000164_gene5544 6.2e-50 204.1 Verrucomicrobia Bacteria 46UNU@74201,COG2755@1,COG2755@2 NA|NA|NA E GDSL-like Lipase/Acylhydrolase family MAG.T1.121_00491 479434.Sthe_0094 7.4e-27 127.5 Chloroflexi ko:K03088 ko00000,ko03021 Bacteria 2G9AH@200795,COG1595@1,COG1595@2 NA|NA|NA K TIGRFAM RNA polymerase sigma factor, sigma-70 family MAG.T1.121_00493 608538.HTH_1591 4.4e-13 81.6 Aquificae tfaE GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 2G45I@200783,COG2110@1,COG2110@2 NA|NA|NA S Appr-1-p processing domain protein MAG.T1.121_00494 309801.trd_A0889 6.1e-45 188.7 Thermomicrobia frsA GO:0003674,GO:0003824,GO:0005575,GO:0006109,GO:0006629,GO:0008150,GO:0008152,GO:0009894,GO:0016020,GO:0016298,GO:0016787,GO:0016788,GO:0019222,GO:0043470,GO:0044238,GO:0050789,GO:0065007,GO:0071704,GO:0080090 3.7.1.19 ko:K11750,ko:K19188 ko00760,ko01120,map00760,map01120 M00810 R07515 RC00800,RC01921 ko00000,ko00001,ko00002,ko01000 Bacteria 27XU7@189775,2G95Q@200795,COG1073@1,COG1073@2 NA|NA|NA S alpha beta MAG.T1.121_00495 1521187.JPIM01000008_gene2112 3.4e-106 392.5 Chloroflexia Bacteria 2G7PS@200795,376WU@32061,COG2866@1,COG2866@2 NA|NA|NA E PFAM peptidase M14, carboxypeptidase A MAG.T1.121_00496 1128421.JAGA01000002_gene1758 1.1e-111 411.4 Bacteria ko:K07114 ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 Bacteria COG2304@1,COG2304@2,COG5426@1,COG5426@2 NA|NA|NA D von Willebrand factor, type A MAG.T1.121_00497 383372.Rcas_1973 9.7e-57 228.4 Chloroflexia Bacteria 2GACU@200795,375FC@32061,COG2304@1,COG2304@2 NA|NA|NA S PFAM von Willebrand factor type A MAG.T1.121_00498 1128421.JAGA01000003_gene3249 1.1e-48 200.7 unclassified Bacteria Bacteria 2NP6B@2323,COG1721@1,COG1721@2 NA|NA|NA S Protein of unknown function DUF58 MAG.T1.121_00499 357808.RoseRS_2701 6.7e-10 72.8 Chloroflexia Bacteria 2GAEF@200795,375SE@32061,COG1511@1,COG1511@2 NA|NA|NA S domain protein MAG.T1.121_00500 765420.OSCT_0611 1e-31 144.8 Chloroflexia Bacteria 2EWUK@1,2GAC8@200795,33Q65@2,3755J@32061 NA|NA|NA MAG.T1.121_00501 485913.Krac_2926 9.6e-91 341.7 Chloroflexi ko:K02282 ko00000,ko02035,ko02044 Bacteria 2G7W3@200795,COG2197@1,COG2197@2,COG3903@1,COG3903@2 NA|NA|NA K transcriptional regulator, LuxR family MAG.T1.121_00503 1382356.JQMP01000003_gene1587 1.8e-60 241.5 Thermomicrobia ko:K14645 ko02024,map02024 ko00000,ko00001,ko01000,ko01002,ko03110 Bacteria 27YUT@189775,2G8ZZ@200795,COG1404@1,COG1404@2,COG1572@1,COG1572@2 NA|NA|NA O CARDB MAG.T1.121_00504 479434.Sthe_2228 2e-13 82.8 Chloroflexi M1-431 Bacteria 2G9AR@200795,COG4283@1,COG4283@2 NA|NA|NA S Protein of unknown function (DUF1706) MAG.T1.121_00505 479434.Sthe_0924 3e-145 521.5 Thermomicrobia recA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360 ko:K03553 ko03440,map03440 M00729 ko00000,ko00001,ko00002,ko03400 Bacteria 27Y25@189775,2G5WE@200795,COG0468@1,COG0468@2 NA|NA|NA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage MAG.T1.121_00507 1173027.Mic7113_1202 1.8e-212 745.7 Oscillatoriales dap2 Bacteria 1G200@1117,1H8T3@1150,COG1506@1,COG1506@2 NA|NA|NA E PFAM Prolyl oligopeptidase family MAG.T1.121_00508 479434.Sthe_1733 2.8e-09 70.1 Chloroflexi Bacteria 2GBHW@200795,COG3103@1,COG4991@2 NA|NA|NA T Bacterial SH3 domain MAG.T1.121_00510 1382356.JQMP01000003_gene1935 1.8e-82 312.8 Thermomicrobia acuC Bacteria 27XTE@189775,2G5X3@200795,COG0123@1,COG0123@2 NA|NA|NA BQ Histone deacetylase domain MAG.T1.121_00511 479434.Sthe_0921 1e-66 260.8 Thermomicrobia Bacteria 27XIX@189775,2G9QF@200795,COG1196@1,COG1196@2 NA|NA|NA D nuclear chromosome segregation MAG.T1.121_00513 525904.Tter_0232 1.6e-111 410.6 unclassified Bacteria Bacteria 2NP78@2323,COG4485@1,COG4485@2 NA|NA|NA S Psort location CytoplasmicMembrane, score MAG.T1.121_00514 1382356.JQMP01000003_gene1940 1.5e-44 188.3 Thermomicrobia ko:K03642,ko:K19223 ko00000,ko01000,ko01002,ko01011 CBM50 Bacteria 27XPH@189775,2G99E@200795,COG0791@1,COG0791@2,COG3103@1,COG4991@2 NA|NA|NA MT NlpC/P60 family MAG.T1.121_00515 1385510.N781_10770 1.3e-19 103.6 Pontibacillus rebM 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 Bacteria 1U9IT@1239,2Y8MF@289201,4HDV5@91061,COG0500@1,COG2226@2 NA|NA|NA Q Methyltransferase MAG.T1.121_00517 1382356.JQMP01000004_gene434 9.4e-120 436.8 Thermomicrobia aroF1 2.5.1.54 ko:K01626,ko:K03856 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 Bacteria 27XKF@189775,2G643@200795,COG2876@1,COG2876@2 NA|NA|NA E NeuB family MAG.T1.121_00518 479434.Sthe_1871 2e-42 178.7 Thermomicrobia aroH GO:0003674,GO:0003824,GO:0004106,GO:0006082,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016866,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044281,GO:0046417,GO:0071704 2.7.4.25,5.4.99.5 ko:K00945,ko:K06208 ko00240,ko00400,ko01100,ko01110,ko01130,ko01230,map00240,map00400,map01100,map01110,map01130,map01230 M00024,M00025,M00052 R00158,R00512,R01665,R01715 RC00002,RC03116 ko00000,ko00001,ko00002,ko01000 Bacteria 27YKI@189775,2G6VB@200795,COG4401@1,COG4401@2 NA|NA|NA E Chorismate mutase type I MAG.T1.121_00519 316274.Haur_1693 2.8e-74 285.4 Chloroflexia trpA 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 Bacteria 2G6AY@200795,374VI@32061,COG0159@1,COG0159@2 NA|NA|NA E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate MAG.T1.121_00520 479434.Sthe_1873 4.6e-166 590.9 Thermomicrobia trpB 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 Bacteria 27XJP@189775,2G5Q3@200795,COG0133@1,COG0133@2 NA|NA|NA E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine MAG.T1.121_00521 1120950.KB892747_gene3739 2.1e-207 728.8 Actinobacteria ko:K06147 ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 2GITR@201174,COG1132@1,COG1132@2 NA|NA|NA V ABC transporter MAG.T1.121_00523 1382356.JQMP01000004_gene410 5.9e-07 61.6 Thermomicrobia ko:K14954 ko05152,map05152 ko00000,ko00001 Bacteria 27ZBK@189775,2DHVB@1,2GB5E@200795,3012B@2 NA|NA|NA S LppX_LprAFG lipoprotein MAG.T1.121_00524 2002.JOEQ01000003_gene2468 8.8e-209 733.4 Streptosporangiales yknV ko:K06147 ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 2GITR@201174,4EMMQ@85012,COG1132@1,COG1132@2 NA|NA|NA V ABC transporter transmembrane region MAG.T1.121_00525 525904.Tter_2143 2.8e-51 208.0 Bacteria ko:K07005 ko00000 Bacteria COG3576@1,COG3576@2 NA|NA|NA S Pyridoxamine 5'-phosphate oxidase MAG.T1.121_00526 479434.Sthe_2696 5.8e-173 614.0 Chloroflexi fumC GO:0003674,GO:0003824,GO:0004333,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0071944,GO:0072350 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 Bacteria 2GBNI@200795,COG0114@1,COG0114@2 NA|NA|NA C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate MAG.T1.121_00527 309801.trd_1309 3.2e-108 398.7 Thermomicrobia moeB GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006732,GO:0006777,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008146,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009108,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0016782,GO:0018130,GO:0019344,GO:0019538,GO:0019637,GO:0019720,GO:0019752,GO:0020012,GO:0030312,GO:0030682,GO:0042783,GO:0043170,GO:0043207,GO:0043436,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051189,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0061605,GO:0070566,GO:0071704,GO:0071944,GO:0075136,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.73,2.7.7.80,2.8.1.11,3.1.2.6 ko:K01069,ko:K03148,ko:K21029,ko:K21147 ko00620,ko00730,ko01100,ko04122,map00620,map00730,map01100,map04122 R01736,R07459,R07461 RC00004,RC00043,RC00137 ko00000,ko00001,ko01000 Bacteria 27YS0@189775,2G5TN@200795,COG0476@1,COG0476@2,COG0607@1,COG0607@2 NA|NA|NA HP ThiF family MAG.T1.121_00528 479434.Sthe_0834 2e-24 119.0 Thermomicrobia 2.5.1.129 ko:K03186 ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 M00117 R01238,R02952,R03367,R04985,R04986,R11225 RC00391,RC00814,RC03392 ko00000,ko00001,ko00002,ko01000 Bacteria 27Z8E@189775,2G751@200795,COG2050@1,COG2050@2 NA|NA|NA Q Thioesterase superfamily MAG.T1.121_00530 1336245.JAGO01000017_gene1152 2.8e-28 131.7 Oceanospirillales cdd GO:0001882,GO:0001884,GO:0003674,GO:0003824,GO:0004126,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006216,GO:0006217,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008655,GO:0009056,GO:0009058,GO:0009116,GO:0009119,GO:0009120,GO:0009164,GO:0009972,GO:0009987,GO:0015949,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0036094,GO:0042454,GO:0042802,GO:0043094,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046087,GO:0046092,GO:0046121,GO:0046125,GO:0046127,GO:0046131,GO:0046133,GO:0046135,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0047844,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0097159,GO:0097367,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.5.4.5 ko:K01489 ko00240,ko00983,ko01100,map00240,map00983,map01100 R01878,R02485,R08221 RC00074,RC00514 ko00000,ko00001,ko01000 iECO103_1326.ECO103_2618 Bacteria 1MY2R@1224,1RMRX@1236,1XQ4F@135619,COG0295@1,COG0295@2 NA|NA|NA F This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis MAG.T1.121_00531 383372.Rcas_0624 3.7e-53 215.7 Chloroflexi 3.5.2.6 ko:K01467 ko01501,ko02020,map01501,map02020 M00628 R06363 RC01499 ko00000,ko00001,ko00002,ko01000 Bacteria 2G8Z2@200795,COG1680@1,COG1680@2 NA|NA|NA V Beta-lactamase MAG.T1.121_00532 358681.BBR47_45560 7.2e-45 187.6 Paenibacillaceae nagB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006040,GO:0008150,GO:0008152,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901135 3.1.1.31,3.5.99.6 ko:K01057,ko:K02564 ko00030,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00520,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R00765,R02035 RC00163,RC00537 ko00000,ko00001,ko00002,ko01000 iYO844.BSU35020 Bacteria 1TP10@1239,26QA7@186822,4HAG4@91061,COG0363@1,COG0363@2 NA|NA|NA G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion MAG.T1.121_00533 926550.CLDAP_23740 3.1e-31 142.5 Bacteria cysQ 3.1.3.7 ko:K01082 ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130 R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03016 Bacteria COG1218@1,COG1218@2 NA|NA|NA P 3'(2'),5'-bisphosphate nucleotidase activity MAG.T1.121_00534 1120972.AUMH01000014_gene2564 8.1e-52 212.6 Alicyclobacillaceae pcrA 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 1TPSU@1239,2786P@186823,4HB12@91061,COG0210@1,COG0210@2 NA|NA|NA L DNA helicase MAG.T1.121_00535 485913.Krac_9866 2.8e-57 229.2 Bacteria Bacteria COG2141@1,COG2141@2 NA|NA|NA C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases MAG.T1.121_00537 1423321.AS29_06235 1.9e-35 156.4 Bacillus yvoA ko:K03710 ko00000,ko03000 Bacteria 1UYBW@1239,1ZBS6@1386,4HDDG@91061,COG2188@1,COG2188@2 NA|NA|NA K transcriptional MAG.T1.121_00538 357808.RoseRS_1083 1.1e-69 270.0 Chloroflexia deoC GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 4.1.2.4 ko:K01619 ko00030,map00030 R01066 RC00436,RC00437 ko00000,ko00001,ko01000 Bacteria 2G7HC@200795,375WJ@32061,COG0274@1,COG0274@2 NA|NA|NA H Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate MAG.T1.121_00539 357808.RoseRS_1084 1.3e-133 483.0 Chloroflexia Bacteria 2G6V1@200795,375S4@32061,COG0673@1,COG0673@2 NA|NA|NA S PFAM oxidoreductase domain protein MAG.T1.121_00540 357808.RoseRS_1085 1e-106 393.3 Chloroflexi Bacteria 2G6W6@200795,COG1082@1,COG1082@2 NA|NA|NA G PFAM Xylose isomerase domain protein TIM barrel MAG.T1.121_00541 1454007.JAUG01000047_gene512 6.9e-113 414.1 Sphingobacteriia MA20_02630 Bacteria 1ISF7@117747,4NJ92@976,COG0673@1,COG0673@2 NA|NA|NA S Oxidoreductase domain protein MAG.T1.121_00542 357808.RoseRS_2512 2.2e-70 272.7 Chloroflexia 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 2G6I0@200795,375NG@32061,COG1940@1,COG1940@2 NA|NA|NA GK PFAM ROK family protein MAG.T1.121_00543 926550.CLDAP_29730 4.2e-88 331.3 Chloroflexi Bacteria 2G6XP@200795,COG4821@1,COG4821@2 NA|NA|NA S SIS domain MAG.T1.121_00544 469383.Cwoe_0449 1.8e-26 126.3 Rubrobacteria Bacteria 2GRE3@201174,4CTPZ@84995,COG3548@1,COG3548@2 NA|NA|NA S Protein of unknown function (DUF1211) MAG.T1.121_00545 134676.ACPL_2038 1.8e-50 206.5 Micromonosporales MA20_35610 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 Bacteria 2IBEF@201174,4DF4I@85008,COG0329@1,COG0329@2 NA|NA|NA EM Dihydrodipicolinate synthetase family MAG.T1.121_00546 266117.Rxyl_0531 9.9e-74 283.5 Rubrobacteria Bacteria 2HP88@201174,4CT17@84995,COG1028@1,COG1028@2 NA|NA|NA IQ KR domain MAG.T1.121_00547 266117.Rxyl_0532 3.9e-140 504.6 Actinobacteria Bacteria 2IDCU@201174,COG2017@1,COG2017@2 NA|NA|NA G Domain of unknown function (DUF4432) MAG.T1.121_00548 266117.Rxyl_2415 3.3e-77 295.0 Rubrobacteria Bacteria 2GMEH@201174,4CQ3X@84995,COG1028@1,COG1028@2 NA|NA|NA IQ Enoyl-(Acyl carrier protein) reductase MAG.T1.121_00549 926550.CLDAP_29720 1.1e-64 253.4 Chloroflexi Bacteria 2G7UH@200795,COG1028@1,COG1028@2 NA|NA|NA IQ Enoyl-(Acyl carrier protein) reductase MAG.T1.121_00550 357808.RoseRS_2516 2.1e-111 409.1 Chloroflexia 2.1.1.14 ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R04405,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 Bacteria 2G7J6@200795,377RE@32061,COG0620@1,COG0620@2 NA|NA|NA H PFAM Methionine synthase, vitamin-B12 independent MAG.T1.121_00551 926550.CLDAP_29710 1.7e-70 273.1 Chloroflexi ko:K07048 ko00000 Bacteria 2G8Y3@200795,COG1735@1,COG1735@2 NA|NA|NA S Phosphotriesterase family MAG.T1.121_00552 1173024.KI912148_gene4266 3.3e-30 138.3 Stigonemataceae Bacteria 1G531@1117,1JKWX@1189,COG4803@1,COG4803@2 NA|NA|NA S Protein of unknown function (DUF1269) MAG.T1.121_00553 309801.trd_1464 1.3e-34 153.3 Thermomicrobia Bacteria 27YBK@189775,2G6ZZ@200795,COG0637@1,COG0637@2 NA|NA|NA S haloacid dehalogenase-like hydrolase MAG.T1.121_00555 438753.AZC_4484 2.9e-67 262.7 Xanthobacteraceae 1.4.3.4 ko:K00274 ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034 M00135 R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354 RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUPQ@1224,2TRVT@28211,3EY6P@335928,COG1231@1,COG1231@2 NA|NA|NA E Flavin containing amine oxidoreductase MAG.T1.121_00556 1463864.JOGO01000033_gene1509 5.3e-16 92.8 Actinobacteria Bacteria 2HMYI@201174,COG3266@1,COG3266@2 NA|NA|NA S PAP2 superfamily MAG.T1.121_00557 1128421.JAGA01000001_gene2275 4e-77 295.0 unclassified Bacteria pmi 5.3.1.8 ko:K01809 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01819 RC00376 ko00000,ko00001,ko00002,ko01000 Bacteria 2NR16@2323,COG1482@1,COG1482@2 NA|NA|NA G Phosphomannose isomerase type I MAG.T1.121_00558 926550.CLDAP_28110 3e-90 338.6 Chloroflexi Bacteria 2G6HH@200795,COG0179@1,COG0179@2 NA|NA|NA Q PFAM fumarylacetoacetate (FAA) hydrolase MAG.T1.121_00559 1382356.JQMP01000001_gene1279 1.6e-149 536.2 Thermomicrobia lpdA GO:0000166,GO:0003674,GO:0003824,GO:0004148,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0009987,GO:0015036,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0016667,GO:0016668,GO:0019725,GO:0019899,GO:0032991,GO:0035375,GO:0036094,GO:0040007,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0045454,GO:0048037,GO:0050660,GO:0050662,GO:0050789,GO:0050794,GO:0051287,GO:0055114,GO:0065007,GO:0065008,GO:0070404,GO:0071944,GO:0097159,GO:1901265,GO:1901363,GO:1902494,GO:1990204 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 27XKQ@189775,2G5MR@200795,COG1249@1,COG1249@2 NA|NA|NA C Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain MAG.T1.121_00561 479434.Sthe_0485 9.2e-74 285.4 Thermomicrobia ko:K15773 ko00000,ko02048,ko03000 Bacteria 27ZD0@189775,2G7W3@200795,COG0457@1,COG0457@2,COG1396@1,COG1396@2,COG3903@1,COG3903@2 NA|NA|NA K Tetratricopeptide repeat MAG.T1.121_00562 1150474.JQJI01000005_gene308 2.6e-61 242.7 Thermotogae yufN ko:K02058,ko:K07335 M00221 ko00000,ko00002,ko02000 3.A.1.2 Bacteria 2GC6T@200918,COG1744@1,COG1744@2 NA|NA|NA S PFAM Basic membrane MAG.T1.121_00563 1540257.JQMW01000011_gene1734 7e-146 524.2 Clostridiaceae 3.6.3.17 ko:K02056 M00221 ko00000,ko00002,ko01000,ko02000 3.A.1.2 Bacteria 1UYQA@1239,24XN8@186801,36UI0@31979,COG3845@1,COG3845@2 NA|NA|NA S ABC transporter MAG.T1.121_00564 926561.KB900623_gene1122 3.2e-62 245.7 Halanaerobiales ko:K02057 M00221 ko00000,ko00002,ko02000 3.A.1.2 Bacteria 1TP1F@1239,2494C@186801,3WAFN@53433,COG4603@1,COG4603@2 NA|NA|NA U PFAM Branched-chain amino acid transport system permease component MAG.T1.121_00565 1408422.JHYF01000017_gene1856 1.9e-73 282.7 Clostridiaceae ko:K02057 M00221 ko00000,ko00002,ko02000 3.A.1.2 Bacteria 1TP8Y@1239,2486N@186801,36EJH@31979,COG1079@1,COG1079@2 NA|NA|NA S Belongs to the binding-protein-dependent transport system permease family MAG.T1.121_00566 1235794.C811_02035 4.8e-12 77.8 Coriobacteriia Bacteria 2HV8T@201174,4CWHF@84998,COG5652@1,COG5652@2 NA|NA|NA S VanZ like family MAG.T1.121_00567 309801.trd_0332 2.6e-25 122.9 Thermomicrobia sdhD ko:K00242,ko:K00246 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00149,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002 Bacteria 27YCT@189775,2G7EN@200795,COG2142@1,COG2142@2 NA|NA|NA C Succinate dehydrogenase/Fumarate reductase transmembrane subunit MAG.T1.121_00568 479434.Sthe_1855 1.9e-38 166.4 Thermomicrobia nfeD ko:K07403 ko00000 Bacteria 27XU8@189775,2G6E2@200795,COG1030@1,COG1030@2 NA|NA|NA O NfeD-like C-terminal, partner-binding MAG.T1.121_00569 479434.Sthe_1856 7.4e-93 347.1 Thermomicrobia qmcA Bacteria 27XRQ@189775,2G5SB@200795,COG0330@1,COG0330@2 NA|NA|NA O prohibitin homologues MAG.T1.121_00570 1033743.CAES01000007_gene2016 6.5e-117 427.6 Paenibacillaceae 4.2.1.6 ko:K01684 ko00052,ko01100,ko01120,map00052,map01100,map01120 M00552 R03033 RC00543 ko00000,ko00001,ko00002,ko01000 Bacteria 1TS0S@1239,26VB1@186822,4HC1G@91061,COG4948@1,COG4948@2 NA|NA|NA M mandelate racemase muconate lactonizing MAG.T1.121_00571 1120950.KB892754_gene6023 1.5e-44 186.8 Propionibacteriales 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 Bacteria 2IBEF@201174,4DVEU@85009,COG0329@1,COG0329@2 NA|NA|NA EM Dihydrodipicolinate synthetase family MAG.T1.121_00572 1121087.AUCK01000025_gene1839 4.4e-22 111.7 Bacillus ylcC 3.4.22.70 ko:K07284 ko00000,ko01000,ko01002,ko01011 Bacteria 1V79B@1239,1ZHDM@1386,4HJ8C@91061,COG3764@1,COG3764@2 NA|NA|NA M Sortase family MAG.T1.121_00573 479434.Sthe_1459 1.4e-122 446.4 Thermomicrobia 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 Bacteria 27XPE@189775,2G66Y@200795,COG0498@1,COG0498@2 NA|NA|NA E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine MAG.T1.121_00574 479434.Sthe_1458 4e-50 205.3 Thermomicrobia thrB GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.1.39 ko:K00872 ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 M00018 R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 iECSE_1348.ECSE_0003,iJN678.thrB,iLJ478.TM0545,iSB619.SA_RS06620 Bacteria 27Y5U@189775,2G6MP@200795,COG0083@1,COG0083@2 NA|NA|NA H Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate MAG.T1.121_00575 406124.ACPC01000018_gene2598 1.1e-27 129.8 Bacillus aacA7 GO:0003674,GO:0003824,GO:0008080,GO:0008150,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0034069,GO:0042221,GO:0046677,GO:0047663,GO:0050896 2.3.1.82 ko:K18816 br01600,ko00000,ko01000,ko01504 Bacteria 1V1NC@1239,1ZIFJ@1386,4ISA1@91061,COG0454@1,COG0456@2 NA|NA|NA K Acetyltransferase (GNAT) domain MAG.T1.121_00576 1210884.HG799474_gene15149 3.2e-64 252.3 Planctomycetes 2.7.1.45 ko:K00874 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00061,M00308,M00631 R01541 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 2IWUH@203682,COG0524@1,COG0524@2 NA|NA|NA G pfkB family carbohydrate kinase MAG.T1.121_00577 935948.KE386494_gene413 1.8e-121 442.6 Thermoanaerobacterales msmX ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 ko00000,ko00001,ko00002,ko02000 3.A.1.1 Bacteria 1TP2M@1239,247JR@186801,42F3H@68295,COG3842@1,COG3842@2 NA|NA|NA P PFAM ABC transporter related MAG.T1.121_00578 743718.Isova_2102 3.7e-77 295.4 Promicromonosporaceae metB 2.5.1.48,4.4.1.8 ko:K01739,ko:K01760,ko:K10764 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04941,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00382,RC00420,RC00488,RC00710,RC01245,RC02303,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 Bacteria 2GMD8@201174,4F3W5@85017,COG0626@1,COG0626@2 NA|NA|NA E Cys/Met metabolism PLP-dependent enzyme MAG.T1.121_00579 479434.Sthe_0735 2.8e-253 881.3 Thermomicrobia nosZ 1.7.2.4 ko:K00376 ko00910,ko01120,map00910,map01120 M00529 R02804 RC02861 ko00000,ko00001,ko00002,ko01000 Bacteria 27YVK@189775,2G8B2@200795,COG4263@1,COG4263@2 NA|NA|NA C nitrous-oxide reductase activity MAG.T1.121_00580 479434.Sthe_0736 2.4e-47 195.7 Thermomicrobia nosL ko:K19342 ko00000 Bacteria 27Z7G@189775,2G8NV@200795,COG4314@1,COG4314@2 NA|NA|NA C lipoprotein involved in nitrous oxide reduction MAG.T1.121_00581 479434.Sthe_0737 4.2e-113 415.2 Thermomicrobia nosD ko:K01990,ko:K07218,ko:K19340 ko02010,map02010 M00254,M00762 ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.132.2 Bacteria 27Z0E@189775,2G7PN@200795,COG1131@1,COG1131@2,COG3420@1,COG3420@2 NA|NA|NA P Domain present in carbohydrate binding proteins and sugar hydrolses MAG.T1.121_00582 479434.Sthe_0737 1.2e-81 310.1 Thermomicrobia nosD ko:K01990,ko:K07218,ko:K19340 ko02010,map02010 M00254,M00762 ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.132.2 Bacteria 27Z0E@189775,2G7PN@200795,COG1131@1,COG1131@2,COG3420@1,COG3420@2 NA|NA|NA P Domain present in carbohydrate binding proteins and sugar hydrolses MAG.T1.121_00583 479434.Sthe_0738 5.8e-88 330.9 Thermomicrobia ko:K01992,ko:K19341 ko02010,map02010 M00254,M00762 ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.132.2 Bacteria 27Z7V@189775,2G8D6@200795,COG1277@1,COG1277@2 NA|NA|NA S ABC-2 family transporter protein MAG.T1.121_00584 479434.Sthe_0739 4.7e-25 120.6 Thermomicrobia ko:K19342 ko00000 Bacteria 27ZA8@189775,2G91T@200795,COG4314@1,COG4314@2 NA|NA|NA C NosL MAG.T1.121_00585 926569.ANT_05310 6.2e-20 104.0 Chloroflexi ctaC GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.9.3.1 ko:K02275,ko:K02282,ko:K17223 ko00190,ko00920,ko01100,ko01120,map00190,map00920,map01100,map01120 M00155,M00595 R00081,R10151 RC00016,RC03151,RC03152 ko00000,ko00001,ko00002,ko01000,ko02035,ko02044 3.D.4.2,3.D.4.4,3.D.4.6 Bacteria 2G6C0@200795,COG1622@1,COG1622@2,COG2010@1,COG2010@2,COG2197@1,COG2197@2 NA|NA|NA C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) MAG.T1.121_00586 926550.CLDAP_15630 3.4e-178 631.7 Chloroflexi proS 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 2G5Q6@200795,COG0442@1,COG0442@2 NA|NA|NA J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS MAG.T1.121_00588 479434.Sthe_0219 3.3e-113 415.2 Thermomicrobia lysJ GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.6.1.11,2.6.1.17 ko:K00821,ko:K05830 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00031,M00763,M00845 R02283,R04475,R09778,R10932 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 27XJF@189775,2G5SG@200795,COG4992@1,COG4992@2 NA|NA|NA E Catalyzes the transfer of the amino group of L-glutamate to LysW -aminoadipate 6-semialdehyde, generating LysW -gamma-L- lysine MAG.T1.121_00589 1382356.JQMP01000004_gene343 3e-76 292.0 Thermomicrobia lysZ GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8,3.5.1.16 ko:K00930,ko:K01438,ko:K05828,ko:K05831 ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230 M00028,M00031,M00763,M00845 R00669,R02649,R09107,R09776,R09779,R10930,R10933 RC00002,RC00043,RC00064,RC00090,RC00300 ko00000,ko00001,ko00002,ko01000 Bacteria 27XZ2@189775,2G5WV@200795,COG0548@1,COG0548@2 NA|NA|NA E Belongs to the acetylglutamate kinase family. LysZ subfamily MAG.T1.121_00590 765420.OSCT_1723 1.2e-64 253.4 Chloroflexi Bacteria 2G8PY@200795,COG2141@1,COG2141@2 NA|NA|NA C COGs COG2141 Coenzyme F420-dependent N5 N10-methylene tetrahydromethanopterin reductase MAG.T1.121_00591 525904.Tter_0319 5.2e-142 510.8 unclassified Bacteria argC 1.2.1.38 ko:K00145,ko:K05829 ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230 M00028,M00031,M00763,M00845 R03443,R09777,R10931 RC00684 ko00000,ko00001,ko00002,ko01000 Bacteria 2NNN5@2323,COG0002@1,COG0002@2 NA|NA|NA E Belongs to the NAGSA dehydrogenase family. Type 1 subfamily MAG.T1.121_00592 525904.Tter_0316 8.7e-106 390.2 unclassified Bacteria lysX 6.3.1.17,6.3.2.32,6.3.2.41,6.3.2.43 ko:K05827,ko:K05844,ko:K14940,ko:K18310 ko00250,ko00300,ko00680,ko01100,ko01120,ko01210,ko01230,map00250,map00300,map00680,map01100,map01120,map01210,map01230 M00031 R09401,R09775,R10677,R10678 RC00064,RC00090,RC00141,RC03233 ko00000,ko00001,ko00002,ko01000,ko03009 Bacteria 2NNM4@2323,COG0189@1,COG0189@2 NA|NA|NA HJ Belongs to the RimK family MAG.T1.121_00593 525904.Tter_0318 1.1e-90 340.1 unclassified Bacteria lysX 6.3.1.17,6.3.2.32,6.3.2.41,6.3.2.43 ko:K05827,ko:K05844,ko:K14940,ko:K18310 ko00250,ko00300,ko00680,ko01100,ko01120,ko01210,ko01230,map00250,map00300,map00680,map01100,map01120,map01210,map01230 M00031 R09401,R09775,R10677,R10678 RC00064,RC00090,RC00141,RC03233 ko00000,ko00001,ko00002,ko01000,ko03009 Bacteria 2NNM4@2323,COG0189@1,COG0189@2 NA|NA|NA HJ Belongs to the RimK family MAG.T1.121_00594 324602.Caur_1204 4.6e-79 301.6 Chloroflexia lysK 3.5.1.16 ko:K01438,ko:K05831 ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230 M00028,M00031,M00763,M00845 R00669,R09107,R09779,R10933 RC00064,RC00090,RC00300 ko00000,ko00001,ko00002,ko01000 Bacteria 2G61X@200795,3758J@32061,COG0624@1,COG0624@2 NA|NA|NA E Catalyzes the release of L-lysine from LysW -gamma-L- lysine MAG.T1.121_00595 649638.Trad_1392 4.6e-17 95.5 Deinococcus-Thermus lysX 6.3.1.17,6.3.2.32,6.3.2.41,6.3.2.43 ko:K05827,ko:K05844,ko:K14940,ko:K18310 ko00250,ko00300,ko00680,ko01100,ko01120,ko01210,ko01230,map00250,map00300,map00680,map01100,map01120,map01210,map01230 M00031 R09401,R09775,R10677,R10678 RC00064,RC00090,RC00141,RC03233 ko00000,ko00001,ko00002,ko01000,ko03009 Bacteria 1WIJ6@1297,COG0189@1,COG0189@2 NA|NA|NA HJ Belongs to the RimK family MAG.T1.121_00597 309798.COPRO5265_1088 1.9e-87 329.7 Thermoanaerobacterales ptcA GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3,2.1.3.6 ko:K00611,ko:K13252 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPF2@1239,248I5@186801,42EK4@68295,COG0078@1,COG0078@2 NA|NA|NA E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline MAG.T1.121_00599 383372.Rcas_3216 4.8e-94 351.3 Chloroflexi strT Bacteria 2G6AM@200795,COG0667@1,COG0667@2 NA|NA|NA C aldo keto reductase MAG.T1.121_00600 639030.JHVA01000001_gene3907 3.3e-150 538.5 Acidobacteria yjgR ko:K06915,ko:K19172 ko00000,ko02048 Bacteria 3Y69X@57723,COG0433@1,COG0433@2 NA|NA|NA S Bacterial protein of unknown function (DUF853) MAG.T1.121_00601 525904.Tter_0453 1.2e-84 320.9 unclassified Bacteria ko:K06158 ko00000,ko03012 Bacteria 2NNPH@2323,COG0488@1,COG0488@2 NA|NA|NA S ABC transporter MAG.T1.121_00602 266117.Rxyl_1089 5.2e-114 417.9 Rubrobacteria metX GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 R01776 RC00004,RC00041 ko00000,ko00001,ko01000 Bacteria 2GKNJ@201174,4CPRW@84995,COG2021@1,COG2021@2 NA|NA|NA E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine MAG.T1.121_00603 485913.Krac_8302 6.4e-166 590.5 Chloroflexi metY 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 Bacteria 2G5NS@200795,COG2873@1,COG2873@2 NA|NA|NA E PFAM Cys Met metabolism pyridoxal-phosphate-dependent protein MAG.T1.121_00607 479434.Sthe_0315 4.4e-92 345.1 Thermomicrobia Bacteria 27Y2R@189775,2G61E@200795,COG1167@1,COG1167@2 NA|NA|NA EK Alanine-glyoxylate amino-transferase MAG.T1.121_00608 485913.Krac_11766 1.5e-49 202.6 Chloroflexi apt 2.4.2.7 ko:K00759 ko00230,ko01100,map00230,map01100 R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko04147 Bacteria 2G8K9@200795,COG0503@1,COG0503@2 NA|NA|NA F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis MAG.T1.121_00609 525904.Tter_0570 5.5e-31 141.7 unclassified Bacteria Bacteria 2NR49@2323,COG1316@1,COG1316@2 NA|NA|NA K Cell envelope-related transcriptional attenuator domain MAG.T1.121_00610 177437.HRM2_35120 4.7e-108 398.3 Desulfobacterales tyrS GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0030312,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 Bacteria 1MVUQ@1224,2MI9Q@213118,2WIP6@28221,42N2A@68525,COG0162@1,COG0162@2 NA|NA|NA J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) MAG.T1.121_00611 485913.Krac_11188 2.1e-23 117.5 Chloroflexi Bacteria 2G8SG@200795,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily MAG.T1.121_00612 479434.Sthe_2139 1.7e-16 92.8 Thermomicrobia Bacteria 27YM2@189775,2BQKR@1,2GA1C@200795,32JGS@2 NA|NA|NA MAG.T1.121_00613 383372.Rcas_3312 1.9e-97 362.8 Chloroflexia 3.4.13.19 ko:K01273 ko00000,ko00537,ko01000,ko01002,ko04147 Bacteria 2G5Y0@200795,375WA@32061,COG2355@1,COG2355@2 NA|NA|NA E PFAM peptidase M19 renal dipeptidase MAG.T1.121_00614 717605.Theco_3027 2.9e-65 255.4 Paenibacillaceae fabI GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006950,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0033554,GO:0036094,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051716,GO:0055114,GO:0065003,GO:0070417,GO:0071704,GO:0071840,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.3.1.10,1.3.1.9 ko:K00208 ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212 M00083,M00572 R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 1TPVD@1239,26RZA@186822,4H9YN@91061,COG0623@1,COG0623@2 NA|NA|NA I Enoyl- acyl-carrier-protein reductase NADH MAG.T1.121_00616 479434.Sthe_1993 2e-109 402.9 Thermomicrobia murD 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 Bacteria 27XFZ@189775,2G5VE@200795,COG0771@1,COG0771@2 NA|NA|NA M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) MAG.T1.121_00617 479434.Sthe_1994 1e-113 416.8 Thermomicrobia mraY GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 iAF987.Gmet_0409,iEC042_1314.EC042_0088,iECABU_c1320.ECABU_c00920,iECED1_1282.ECED1_0088,iECH74115_1262.ECH74115_0095,iECSP_1301.ECSP_0090,iECs_1301.ECs0091,iG2583_1286.G2583_0091,iSDY_1059.SDY_0117,iZ_1308.Z0097,ic_1306.c0105 Bacteria 27Y23@189775,2G5TJ@200795,COG0472@1,COG0472@2 NA|NA|NA M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan MAG.T1.121_00618 309801.trd_0059 1.5e-102 380.2 Thermomicrobia murF 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 Bacteria 27XZI@189775,2G5PN@200795,COG0770@1,COG0770@2 NA|NA|NA M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein MAG.T1.121_00619 479434.Sthe_1998 6.3e-83 314.3 Thermomicrobia rsmH 2.1.1.199 ko:K03438 ko00000,ko01000,ko03009 Bacteria 27XI5@189775,2G658@200795,COG0275@1,COG0275@2 NA|NA|NA J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA MAG.T1.121_00620 479434.Sthe_1999 1.1e-45 189.5 Thermomicrobia mraZ ko:K03925 ko00000 Bacteria 27YAY@189775,2G6ZC@200795,COG2001@1,COG2001@2 NA|NA|NA K MraZ protein, putative antitoxin-like MAG.T1.121_00621 67373.JOBF01000011_gene3337 2.1e-28 133.3 Bacteria 2.7.1.119 ko:K17880 ko00000,ko01000,ko01504 Bacteria COG3173@1,COG3173@2 NA|NA|NA S very-long-chain-acyl-CoA dehydrogenase activity MAG.T1.121_00622 479434.Sthe_2003 3e-158 565.5 Chloroflexi 6.3.4.14,6.4.1.2,6.4.1.3 ko:K01961,ko:K11263 ko00061,ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376,M00741 R00742,R01859,R04385 RC00040,RC00097,RC00253,RC00367,RC00609 ko00000,ko00001,ko00002,ko01000 Bacteria 2G62X@200795,COG0439@1,COG0439@2 NA|NA|NA I Carbamoyl-phosphate synthetase large chain domain protein MAG.T1.121_00624 479434.Sthe_1095 3.2e-173 615.1 Thermomicrobia 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 Bacteria 27XIE@189775,2GBV7@200795,COG0028@1,COG0028@2 NA|NA|NA EH Belongs to the TPP enzyme family MAG.T1.121_00625 1227487.C474_20164 2.1e-40 172.6 Halobacteria Archaea 23V6V@183963,2XWBK@28890,COG1853@1,arCOG02017@2157 NA|NA|NA S COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family MAG.T1.121_00626 1128421.JAGA01000001_gene2190 1.1e-94 353.6 unclassified Bacteria ko:K15975 ko00000 Bacteria 2NR6J@2323,COG0346@1,COG0346@2 NA|NA|NA E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily MAG.T1.121_00627 1120973.AQXL01000135_gene1466 4e-67 261.9 Alicyclobacillaceae 3.5.3.11,3.5.3.8 ko:K01479,ko:K01480 ko00330,ko00340,ko01100,map00330,map00340,map01100 M00045,M00133 R01157,R02285 RC00024,RC00221,RC00329,RC00681 ko00000,ko00001,ko00002,ko01000 Bacteria 1TP2A@1239,2797A@186823,4HCKQ@91061,COG0010@1,COG0010@2 NA|NA|NA E Arginase family MAG.T1.121_00628 99598.Cal7507_4484 2.7e-59 235.3 Nostocales Bacteria 1GBMH@1117,1HS2T@1161,COG5553@1,COG5553@2 NA|NA|NA S Cysteine dioxygenase type I MAG.T1.121_00629 525904.Tter_0589 1.6e-86 325.9 unclassified Bacteria ko:K01996 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 2NNXF@2323,COG0410@1,COG0410@2 NA|NA|NA E ABC transporter MAG.T1.121_00630 1173027.Mic7113_0199 3.6e-80 305.1 Oscillatoriales ko:K01995 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 1G07Z@1117,1H9QZ@1150,COG0411@1,COG0411@2 NA|NA|NA E Amino acid amide ABC transporter ATP-binding protein 1, HAAT family MAG.T1.121_00631 525904.Tter_0587 7.4e-92 344.4 unclassified Bacteria livM ko:K01998 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 2NPMP@2323,COG4177@1,COG4177@2 NA|NA|NA U Branched-chain amino acid transport system / permease component MAG.T1.121_00632 1283299.AUKG01000004_gene1186 8.9e-80 303.9 Rubrobacteria ko:K01997 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 2GMAY@201174,4CPRG@84995,COG0559@1,COG0559@2 NA|NA|NA E Belongs to the binding-protein-dependent transport system permease family MAG.T1.121_00633 402777.KB235903_gene854 3e-73 282.7 Oscillatoriales ko:K01999 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 1G16P@1117,1H80W@1150,COG0683@1,COG0683@2 NA|NA|NA E Receptor family ligand binding region MAG.T1.121_00634 479434.Sthe_1379 3.5e-24 118.2 Thermomicrobia Bacteria 27YK0@189775,2BQKM@1,2GBAT@200795,32JGN@2 NA|NA|NA MAG.T1.121_00635 309801.trd_1190 3.9e-163 581.6 Thermomicrobia ade GO:0000034,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005506,GO:0006040,GO:0006044,GO:0006046,GO:0006139,GO:0006144,GO:0006145,GO:0006146,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008448,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0016787,GO:0016810,GO:0016811,GO:0016814,GO:0018130,GO:0019213,GO:0019239,GO:0019438,GO:0019439,GO:0030145,GO:0034641,GO:0042221,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0046083,GO:0046100,GO:0046101,GO:0046112,GO:0046113,GO:0046148,GO:0046348,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055086,GO:0055114,GO:0070887,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:0097237,GO:0098754,GO:0098869,GO:1901071,GO:1901072,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1990748 3.5.4.2 ko:K01486 ko00230,ko01100,map00230,map01100 R01244 RC00477 ko00000,ko00001,ko01000 iECUMN_1333.ECUMN_4192,iSFV_1184.SFV_3844,iYO844.BSU14520 Bacteria 27XVC@189775,2G64P@200795,COG1001@1,COG1001@2 NA|NA|NA F Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family MAG.T1.121_00636 1382306.JNIM01000001_gene1996 3.6e-129 468.8 Chloroflexi nadB GO:0008150,GO:0040007 1.3.5.4,1.4.3.16,2.4.2.19 ko:K00244,ko:K00278,ko:K00767 ko00020,ko00190,ko00250,ko00620,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00250,map00620,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00115,M00150,M00173 R00357,R00481,R02164,R03348 RC00006,RC00045,RC02566,RC02877 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1595 Bacteria 2G5JM@200795,COG0029@1,COG0029@2 NA|NA|NA H Catalyzes the oxidation of L-aspartate to iminoaspartate MAG.T1.121_00637 1382356.JQMP01000001_gene911 1e-86 327.4 Thermomicrobia folC GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 iLJ478.TM0166,iSB619.SA_RS08370 Bacteria 27Y4Y@189775,2G64M@200795,COG0285@1,COG0285@2 NA|NA|NA H Mur ligase family, glutamate ligase domain MAG.T1.121_00638 1382356.JQMP01000004_gene183 2.8e-50 205.3 Thermomicrobia ko:K03088 ko00000,ko03021 Bacteria 27YAV@189775,2G6UE@200795,COG1595@1,COG1595@2 NA|NA|NA K ECF sigma factor MAG.T1.121_00640 1192034.CAP_7451 5e-87 328.2 Myxococcales arnC 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 R01009 RC00005 ko00000,ko00001,ko01000,ko01003 GT2 Bacteria 1MWE5@1224,2WIYP@28221,2YYXE@29,42MCE@68525,COG0463@1,COG0463@2 NA|NA|NA M Glycosyltransferase like family 2 MAG.T1.121_00641 479434.Sthe_0850 1.4e-11 77.4 Thermomicrobia ko:K07027 ko00000,ko02000 4.D.2 Bacteria 27YMD@189775,2GBB4@200795,COG0392@1,COG0392@2 NA|NA|NA S Lysylphosphatidylglycerol synthase TM region MAG.T1.121_00642 351160.RCIX209 3e-28 132.1 Methanomicrobia Archaea 2NAUS@224756,2Y3U4@28890,COG0500@1,arCOG01789@2157 NA|NA|NA Q Methionine biosynthesis protein MetW MAG.T1.121_00643 246197.MXAN_1497 7.4e-10 72.4 Bacteria 2.7.11.1 ko:K12132 ko00000,ko01000,ko01001 Bacteria COG1520@1,COG1520@2 NA|NA|NA S amino acid activation for nonribosomal peptide biosynthetic process MAG.T1.121_00644 479434.Sthe_2054 1.5e-167 596.3 Thermomicrobia ilvB 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 Bacteria 27XX3@189775,2G810@200795,COG0028@1,COG0028@2 NA|NA|NA EH Belongs to the TPP enzyme family MAG.T1.121_00645 452662.SJA_C1-23730 3.5e-13 82.8 Bacteria Bacteria 2ECPS@1,336MI@2 NA|NA|NA MAG.T1.121_00646 292459.STH2313 5.6e-65 254.6 Clostridia ko:K02034,ko:K13891,ko:K15582 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00348,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.11,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 1TP4R@1239,2489T@186801,COG1173@1,COG1173@2 NA|NA|NA P ABC-type dipeptide oligopeptide nickel transport MAG.T1.121_00647 869210.Marky_2239 1.8e-80 306.2 Deinococcus-Thermus yliC ko:K02033 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 1WJIM@1297,COG0601@1,COG0601@2 NA|NA|NA P COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components MAG.T1.121_00648 1123065.ATWL01000031_gene3370 5.5e-47 195.7 Actinobacteria ko:K02035 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 2GJ4B@201174,COG0747@1,COG0747@2 NA|NA|NA E Extracellular solute-binding protein, family 5 MAG.T1.121_00649 1449347.JQLN01000001_gene369 7.4e-19 101.3 Kitasatospora ko:K01992,ko:K19341 ko02010,map02010 M00254,M00762 ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.132.2 Bacteria 2I1PU@201174,2M4RN@2063,COG1277@1,COG1277@2 NA|NA|NA S ABC-2 family transporter protein MAG.T1.121_00650 309801.trd_0013 1.3e-59 236.9 Thermomicrobia yjjC ko:K01990,ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 27XXC@189775,2G5QI@200795,COG1131@1,COG1131@2 NA|NA|NA V AAA domain, putative AbiEii toxin, Type IV TA system MAG.T1.121_00652 1382306.JNIM01000001_gene780 2e-22 112.5 Bacteria Bacteria 2DN66@1,32VSD@2 NA|NA|NA S Protein of unknown function (DUF664) MAG.T1.121_00653 479434.Sthe_2193 2.1e-45 189.1 Thermomicrobia blaB4 1.1.1.306,3.1.2.6 ko:K00153,ko:K01069 ko00620,map00620 R01736,R09129,R10301 RC00004,RC00069,RC00137,RC01715 ko00000,ko00001,ko01000 Bacteria 27YDW@189775,2G6X9@200795,COG0491@1,COG0491@2 NA|NA|NA S Metallo-beta-lactamase superfamily MAG.T1.121_00654 479434.Sthe_1353 1.6e-74 286.6 Thermomicrobia 3.1.3.97 ko:K07053 R00188,R11188 RC00078 ko00000,ko01000 Bacteria 27XQC@189775,2G71S@200795,COG0613@1,COG0613@2 NA|NA|NA S DNA polymerase alpha chain like domain MAG.T1.121_00655 1382356.JQMP01000004_gene103 5.2e-155 554.3 Thermomicrobia manB GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 5.4.2.2,5.4.2.8 ko:K01840,ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 iECS88_1305.ECS88_2145,iECUMN_1333.ECUMN_2384,iUTI89_1310.UTI89_C2321 Bacteria 27XV0@189775,2G5YP@200795,COG1109@1,COG1109@2 NA|NA|NA G Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III MAG.T1.121_00656 479434.Sthe_1356 9e-36 156.8 Thermomicrobia ko:K07586,ko:K09145 ko00000 Bacteria 27YHI@189775,2GBPB@200795,COG2306@1,COG2306@2 NA|NA|NA S Protein of unknown function (DUF402) MAG.T1.121_00657 1386089.N865_16750 1e-106 393.7 Intrasporangiaceae dmpA 3.4.11.19 ko:K01266 ko00000,ko01000,ko01002 Bacteria 2H89D@201174,4FGPH@85021,COG3191@1,COG3191@2 NA|NA|NA EQ Peptidase family S58 MAG.T1.121_00659 479434.Sthe_2005 1.3e-202 712.6 Thermomicrobia pccB GO:0003674,GO:0003824,GO:0003989,GO:0004658,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009317,GO:0009987,GO:0015977,GO:0016020,GO:0016042,GO:0016054,GO:0016421,GO:0016874,GO:0016885,GO:0019752,GO:0030312,GO:0032787,GO:0032991,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:0071944,GO:0072329,GO:1901575,GO:1902494 2.1.3.15,6.4.1.3,6.4.1.4 ko:K01966,ko:K01969 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00036,M00373,M00741 R01859,R04138 RC00097,RC00367,RC00609,RC00942 ko00000,ko00001,ko00002,ko01000 Bacteria 27YUV@189775,2G5IX@200795,COG4799@1,COG4799@2 NA|NA|NA I Carboxyl transferase domain MAG.T1.121_00660 479434.Sthe_2008 8.6e-205 719.9 Thermomicrobia bhbA 5.4.99.2 ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 Bacteria 27XPT@189775,2G5TP@200795,COG1884@1,COG1884@2 NA|NA|NA I Methylmalonyl-CoA mutase MAG.T1.121_00661 479434.Sthe_2009 6.1e-33 147.1 Thermomicrobia mce 4.4.1.5,5.1.99.1,5.4.99.2 ko:K01759,ko:K01849,ko:K05606 ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00620,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R00833,R02530,R02765,R09979 RC00004,RC00395,RC00740,RC00780,RC02739 ko00000,ko00001,ko00002,ko01000 Bacteria 27YM9@189775,2G79M@200795,COG0346@1,COG0346@2 NA|NA|NA E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily MAG.T1.121_00662 309801.trd_1927 3.4e-163 582.4 Thermomicrobia mrdA 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 ko00000,ko00001,ko01000,ko01011 Bacteria 27Y4X@189775,2G64Z@200795,COG0768@1,COG0768@2 NA|NA|NA M Penicillin-binding Protein dimerisation domain MAG.T1.121_00663 479434.Sthe_2014 5.2e-28 131.0 Thermomicrobia mreD GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008360,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944 ko:K03571 ko00000,ko03036 9.B.157.1 Bacteria 27YRC@189775,2GBC9@200795,COG2891@1,COG2891@2 NA|NA|NA M Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins MAG.T1.121_00664 479434.Sthe_0146 2.7e-74 285.4 Thermomicrobia cobQ ko:K07009 ko00000 iSB619.SA_RS09800 Bacteria 27XXH@189775,2G6KU@200795,COG3442@1,COG3442@2 NA|NA|NA H CobB/CobQ-like glutamine amidotransferase domain MAG.T1.121_00665 479434.Sthe_0145 1.1e-134 486.9 Thermomicrobia murD 3.4.21.10,6.3.2.13,6.3.2.9 ko:K01317,ko:K01925,ko:K01928,ko:K01932 ko00300,ko00471,ko00550,ko01100,map00300,map00471,map00550,map01100 R02783,R02788 RC00064,RC00090,RC00141 ko00000,ko00001,ko01000,ko01002,ko01011,ko04131 Bacteria 27XXI@189775,2GBHB@200795,COG0771@1,COG0771@2 NA|NA|NA M Domain of unknown function (DUF1727) MAG.T1.121_00666 479434.Sthe_0144 1.2e-46 193.7 Thermomicrobia mreC GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008360,GO:0009273,GO:0009987,GO:0016020,GO:0022603,GO:0022604,GO:0030428,GO:0042546,GO:0043621,GO:0044085,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071554,GO:0071840,GO:0071944 ko:K03570 ko00000,ko03036 9.B.157.1 Bacteria 27YGP@189775,2G743@200795,COG1792@1,COG1792@2 NA|NA|NA M Involved in formation and maintenance of cell shape MAG.T1.121_00667 479434.Sthe_0143 1.4e-171 609.0 Thermomicrobia mreB ko:K03569 ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 Bacteria 27XN7@189775,2G62K@200795,COG1077@1,COG1077@2 NA|NA|NA D Cell division protein FtsA MAG.T1.121_00669 1237149.C900_00493 7.1e-07 60.8 Bacteria sodC 1.15.1.1 ko:K02674,ko:K04565 ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020 ko00000,ko00001,ko01000,ko02035,ko02044 Bacteria COG2032@1,COG2032@2 NA|NA|NA P superoxide dismutase activity MAG.T1.121_00670 485913.Krac_9793 6.1e-73 282.0 Chloroflexi Bacteria 2G6KS@200795,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor MAG.T1.121_00671 582899.Hden_2935 5.4e-63 247.7 Hyphomicrobiaceae Bacteria 1MWZ5@1224,2TV3A@28211,3N8C7@45401,COG0745@1,COG0745@2 NA|NA|NA K Transcriptional regulatory protein, C terminal MAG.T1.121_00672 1382356.JQMP01000003_gene1961 1.3e-11 76.3 Chloroflexi Bacteria 2G9SH@200795,COG0745@1,COG0745@2 NA|NA|NA T SPTR D1CGX5 Response regulator receiver protein MAG.T1.121_00674 412597.AEPN01000010_gene1887 4.8e-201 707.6 Paracoccus kdpA GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0030955,GO:0031420,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 ko:K01546 ko02020,map02020 ko00000,ko00001,ko01000 3.A.3.7 Bacteria 1MV1K@1224,2PVX2@265,2TSIJ@28211,COG2060@1,COG2060@2 NA|NA|NA P Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane MAG.T1.121_00675 258594.RPA3003 1.4e-239 835.9 Bradyrhizobiaceae kdpB 3.6.3.12 ko:K01547 ko02020,map02020 ko00000,ko00001,ko01000 3.A.3.7 Bacteria 1MU7D@1224,2TREM@28211,3JQUQ@41294,COG2216@1,COG2216@2 NA|NA|NA P Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system MAG.T1.121_00676 1287116.X734_09005 1.1e-51 209.9 Phyllobacteriaceae kdpC GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 ko:K01548 ko02020,map02020 ko00000,ko00001,ko01000 3.A.3.7 iETEC_1333.kdpC Bacteria 1RABG@1224,2TSQ7@28211,43JU6@69277,COG2156@1,COG2156@2 NA|NA|NA P Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex MAG.T1.121_00677 485913.Krac_7334 1.3e-201 709.5 Chloroflexi kdpA GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0030955,GO:0031420,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 ko:K01546 ko02020,map02020 ko00000,ko00001,ko01000 3.A.3.7 Bacteria 2G5KK@200795,COG2060@1,COG2060@2 NA|NA|NA P Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane MAG.T1.121_00678 485913.Krac_1609 4.6e-91 341.7 Chloroflexi Bacteria 2G601@200795,COG0642@1,COG2205@2 NA|NA|NA T Osmosensitive K+ channel His kinase sensor domain MAG.T1.121_00679 479434.Sthe_2058 1.8e-298 1031.9 Thermomicrobia sucA GO:0000287,GO:0003674,GO:0003824,GO:0004591,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016624,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0019842,GO:0022900,GO:0030312,GO:0030976,GO:0032991,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0048037,GO:0050439,GO:0050662,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234 1.2.4.2,4.1.1.71 ko:K00164,ko:K01616 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1248c,iSSON_1240.SSON_0677,iYL1228.KPN_00732 Bacteria 27XYT@189775,2G638@200795,COG0567@1,COG0567@2 NA|NA|NA C 2-oxoglutarate dehydrogenase N-terminus MAG.T1.121_00680 479434.Sthe_2057 5.3e-128 464.5 Thermomicrobia sucB GO:0003674,GO:0003824,GO:0004149,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008289,GO:0009060,GO:0009987,GO:0015980,GO:0016417,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016751,GO:0016999,GO:0017144,GO:0019752,GO:0031405,GO:0031406,GO:0032991,GO:0033293,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:0140096,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2766,iAPECO1_1312.APECO1_1352,iECED1_1282.ECED1_0696,iECOK1_1307.ECOK1_0726,iECS88_1305.ECS88_0752,iLF82_1304.LF82_2196,iNRG857_1313.NRG857_03235,iUMN146_1321.UM146_13990,iUTI89_1310.UTI89_C0722 Bacteria 27XXQ@189775,2G7SG@200795,COG0508@1,COG0508@2 NA|NA|NA C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) MAG.T1.121_00681 1123242.JH636434_gene4721 1.7e-36 159.1 Planctomycetes bfr GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008150,GO:0009987,GO:0019725,GO:0030003,GO:0042592,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0097577,GO:0098771 1.16.3.1 ko:K03594 ko00860,map00860 R00078 RC02758 ko00000,ko00001,ko01000 Bacteria 2J19B@203682,COG2193@1,COG2193@2 NA|NA|NA P Ferritin-like domain MAG.T1.121_00682 525904.Tter_2237 1.4e-102 380.2 unclassified Bacteria norM ko:K03327 ko00000,ko02000 2.A.66.1 Bacteria 2NPBA@2323,COG0534@1,COG0534@2 NA|NA|NA V MATE efflux family protein MAG.T1.121_00683 290397.Adeh_2155 3.6e-35 154.5 Myxococcales Bacteria 1RK5X@1224,2CP0Z@1,2X904@28221,2Z0HI@29,32SI8@2,434SF@68525 NA|NA|NA S Protein of unknown function (DUF3037) MAG.T1.121_00684 251221.35213336 1.6e-78 299.7 Cyanobacteria Bacteria 1G3HN@1117,COG1718@1,COG1718@2 NA|NA|NA DT Serine threonine protein kinase involved in cell cycle control MAG.T1.121_00685 1463917.JODC01000010_gene3779 2.9e-15 89.4 Actinobacteria 1.7.2.1 ko:K00368 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 Bacteria 2H73G@201174,COG3794@1,COG3794@2 NA|NA|NA C Copper binding proteins, plastocyanin/azurin family MAG.T1.121_00686 1382356.JQMP01000003_gene1593 1.9e-135 489.6 Thermomicrobia ko:K02035 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 27YW8@189775,2GA2W@200795,COG0747@1,COG0747@2 NA|NA|NA E Bacterial extracellular solute-binding proteins, family 5 Middle MAG.T1.121_00687 1382356.JQMP01000003_gene1594 6.7e-104 384.0 Thermomicrobia oppB6 ko:K02033 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 27YZJ@189775,2GA3B@200795,COG0601@1,COG0601@2 NA|NA|NA EP Binding-protein-dependent transport system inner membrane component MAG.T1.121_00688 1382356.JQMP01000003_gene1595 3.1e-106 391.7 Thermomicrobia appC ko:K02034 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 27YTR@189775,2G853@200795,COG1173@1,COG1173@2 NA|NA|NA EP N-terminal TM domain of oligopeptide transport permease C MAG.T1.121_00690 926550.CLDAP_07260 7.9e-13 80.1 Bacteria Bacteria 2E3MN@1,32YJW@2 NA|NA|NA MAG.T1.121_00691 316274.Haur_1299 2.2e-22 113.6 Bacteria Bacteria 2DWKD@1,340UV@2 NA|NA|NA MAG.T1.121_00692 1121378.KB899737_gene3936 8.8e-88 330.9 Deinococcus-Thermus 3.4.13.9 ko:K01271 ko00000,ko01000,ko01002 Bacteria 1WIXQ@1297,COG0006@1,COG0006@2 NA|NA|NA E PFAM Metallopeptidase family M24 MAG.T1.121_00695 1382356.JQMP01000003_gene2065 3.1e-100 371.7 Thermomicrobia amrA ko:K06990,ko:K15755 ko00621,ko01100,ko01120,ko01220,map00621,map01100,map01120,map01220 M00544 R05415 RC01306 br01602,ko00000,ko00001,ko00002,ko01000,ko04812 Bacteria 27Y2B@189775,2GB8J@200795,COG3885@1,COG3885@2 NA|NA|NA C PFAM Extradiol ring-cleavage dioxygenase class III protein subunit B MAG.T1.121_00696 1382356.JQMP01000003_gene1440 7.7e-28 131.3 Thermomicrobia Bacteria 27Y8A@189775,2G768@200795,COG0589@1,COG0589@2 NA|NA|NA T Belongs to the universal stress protein A family MAG.T1.121_00697 357808.RoseRS_4248 9.4e-99 367.5 Bacteria ko:K02027 M00207 ko00000,ko00002,ko02000 3.A.1.1 Bacteria COG1653@1,COG1653@2 NA|NA|NA G carbohydrate transport MAG.T1.121_00698 383372.Rcas_0479 4e-88 331.6 Bacteria ko:K02025,ko:K05814,ko:K15771,ko:K17316 ko02010,map02010 M00198,M00207,M00491,M00605 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.2,3.A.1.1.24,3.A.1.1.3,3.A.1.1.30 Bacteria COG1175@1,COG1175@2 NA|NA|NA P transmembrane transport MAG.T1.121_00699 357808.RoseRS_4250 3.3e-60 238.8 Bacteria ko:K02026 M00207 ko00000,ko00002,ko02000 3.A.1.1 Bacteria COG0395@1,COG0395@2 NA|NA|NA P glycerophosphodiester transmembrane transport MAG.T1.121_00700 357808.RoseRS_4250 1.8e-42 179.9 Bacteria ko:K02026 M00207 ko00000,ko00002,ko02000 3.A.1.1 Bacteria COG0395@1,COG0395@2 NA|NA|NA P glycerophosphodiester transmembrane transport MAG.T1.121_00702 330084.JNYZ01000008_gene6566 2.6e-61 242.3 Pseudonocardiales Bacteria 2GP7P@201174,4EBXB@85010,COG1028@1,COG1028@2 NA|NA|NA IQ Enoyl-(Acyl carrier protein) reductase MAG.T1.121_00703 1469607.KK073766_gene104 1e-22 113.2 Cyanobacteria Bacteria 1G7EE@1117,2DNS7@1,32YWC@2 NA|NA|NA S PFAM S23 ribosomal protein MAG.T1.121_00704 309801.trd_0880 1.8e-109 402.9 Bacteria 1.5.3.19 ko:K19191 ko00760,ko01120,map00760,map01120 R10102 RC00060,RC00557 ko00000,ko00001,ko01000 Bacteria COG0665@1,COG0665@2 NA|NA|NA E tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity MAG.T1.121_00706 1089551.KE386572_gene975 1.2e-85 323.2 unclassified Alphaproteobacteria ko:K02049 M00188 ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 Bacteria 1N7FP@1224,2TRKZ@28211,4BR7S@82117,COG1116@1,COG1116@2 NA|NA|NA P ATPases associated with a variety of cellular activities MAG.T1.121_00707 1122132.AQYH01000003_gene3188 8.6e-87 327.0 Rhizobiaceae tauC ko:K02049,ko:K02050 M00188 ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 Bacteria 1MVAE@1224,2TSAS@28211,4B98J@82115,COG0600@1,COG0600@2 NA|NA|NA P ABC-type nitrate sulfonate bicarbonate transport system, permease component MAG.T1.121_00708 1089551.KE386572_gene973 1.4e-87 330.1 Alphaproteobacteria ttrS 2.7.13.3 ko:K09967,ko:K13040 ko02020,map02020 M00514 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 1NYKG@1224,2TTTW@28211,COG0715@1,COG0715@2 NA|NA|NA P NMT1/THI5 like MAG.T1.121_00709 344747.PM8797T_12533 8.5e-18 96.7 Bacteria Bacteria 2DMM9@1,32SDB@2 NA|NA|NA MAG.T1.121_00710 1121936.AUHI01000003_gene1877 7.6e-48 197.6 Firmicutes 4.2.1.44 ko:K03335 ko00562,ko01100,ko01120,map00562,map01100,map01120 R02782,R05659 RC00782,RC01448 ko00000,ko00001,ko01000 Bacteria 1V59P@1239,COG1082@1,COG1082@2 NA|NA|NA G Xylose isomerase-like TIM barrel MAG.T1.121_00711 1499967.BAYZ01000138_gene181 8.1e-52 211.1 unclassified Bacteria Bacteria 2NR8T@2323,COG0673@1,COG0673@2 NA|NA|NA S Oxidoreductase family, C-terminal alpha/beta domain MAG.T1.121_00713 479434.Sthe_2635 2.5e-17 95.9 Thermomicrobia Bacteria 27YJQ@189775,2E4KM@1,2GBAS@200795,32ZFK@2 NA|NA|NA MAG.T1.121_00714 479434.Sthe_3300 1.2e-165 589.7 Thermomicrobia Bacteria 27Y37@189775,2G86Q@200795,COG0665@1,COG0665@2 NA|NA|NA E FAD dependent oxidoreductase MAG.T1.121_00715 479434.Sthe_1897 3.4e-07 62.8 Bacteria Bacteria COG1714@1,COG1714@2 NA|NA|NA S RDD family MAG.T1.121_00716 634176.NT05HA_0366 1.6e-14 87.0 Pasteurellales kefA GO:0005575,GO:0005623,GO:0005886,GO:0006884,GO:0008150,GO:0008361,GO:0009987,GO:0009992,GO:0016020,GO:0016043,GO:0019725,GO:0030104,GO:0032535,GO:0042592,GO:0044464,GO:0048878,GO:0055082,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066 ko:K05802,ko:K22051 ko00000,ko02000 1.A.23.1.1,1.A.23.1.2,1.A.23.1.3 Bacteria 1MWSA@1224,1RMYY@1236,1Y701@135625,COG3096@1,COG3096@2,COG3264@1,COG3264@2 NA|NA|NA M Small-conductance mechanosensitive channel MAG.T1.121_00717 179408.Osc7112_5638 1.9e-14 86.7 Oscillatoriales Bacteria 1G9UD@1117,1HF6C@1150,COG3021@1,COG3021@2 NA|NA|NA S PFAM Endonuclease Exonuclease phosphatase MAG.T1.121_00719 479434.Sthe_1819 1.6e-28 132.5 Thermomicrobia ko:K03711 ko00000,ko03000 Bacteria 27Z9F@189775,2G723@200795,COG0735@1,COG0735@2 NA|NA|NA P Ferric uptake regulator family MAG.T1.121_00720 316274.Haur_2846 1.2e-95 356.7 Chloroflexia znuA ko:K02077,ko:K09815,ko:K09818 ko02010,map02010 M00242,M00243,M00244 ko00000,ko00001,ko00002,ko02000 3.A.1.15,3.A.1.15.3,3.A.1.15.5 Bacteria 2G8F6@200795,37738@32061,COG0803@1,COG0803@2 NA|NA|NA P Belongs to the bacterial solute-binding protein 9 family MAG.T1.121_00721 1266925.JHVX01000001_gene2541 1.4e-65 256.5 Nitrosomonadales ko:K02074,ko:K09817 ko02010,map02010 M00242,M00244 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.15,3.A.1.15.3,3.A.1.15.5 Bacteria 1MW47@1224,2VNES@28216,372B0@32003,COG1121@1,COG1121@2 NA|NA|NA P AAA domain, putative AbiEii toxin, Type IV TA system MAG.T1.121_00722 316274.Haur_2844 3.6e-78 298.5 Chloroflexia ko:K09816,ko:K09819 ko02010,map02010 M00242,M00243 ko00000,ko00001,ko00002,ko02000 3.A.1.15,3.A.1.15.3,3.A.1.15.5 Bacteria 2G6GH@200795,376AB@32061,COG1108@1,COG1108@2 NA|NA|NA P ABC-3 protein MAG.T1.121_00723 1121272.KB903283_gene4985 5.5e-122 444.5 Micromonosporales Bacteria 2I9UI@201174,4DBRI@85008,COG4354@1,COG4354@2 NA|NA|NA G beta-glucosidase 2, glycosyl-hydrolase family 116 N-term MAG.T1.121_00724 1382356.JQMP01000003_gene1648 1.2e-30 139.4 Thermomicrobia Bacteria 27XU2@189775,2G7ER@200795,COG3568@1,COG3568@2 NA|NA|NA S Endonuclease/Exonuclease/phosphatase family MAG.T1.121_00725 1267005.KB911257_gene825 1.4e-25 123.6 Alphaproteobacteria 3.5.2.10 ko:K01470 ko00330,map00330 R01884 RC00615 ko00000,ko00001,ko01000 Bacteria 1MXR9@1224,2TUFR@28211,COG1402@1,COG1402@2 NA|NA|NA S Creatininase MAG.T1.121_00726 1500306.JQLA01000017_gene4898 4.5e-31 142.1 Rhizobiaceae 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 Bacteria 1R5DG@1224,2TWFF@28211,4BJ10@82115,COG0451@1,COG0451@2 NA|NA|NA M Male sterility protein MAG.T1.121_00727 1382356.JQMP01000003_gene1921 2.5e-139 502.3 Thermomicrobia argH GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0030312,GO:0040007,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 iJN678.argH Bacteria 27XG0@189775,2G616@200795,COG0165@1,COG0165@2 NA|NA|NA E argininosuccinate lyase MAG.T1.121_00728 1382356.JQMP01000003_gene1922 4.3e-19 101.3 Thermomicrobia yjcF GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0016747 ko:K02348 ko00000 Bacteria 27YGQ@189775,2G9IV@200795,COG2153@1,COG2153@2 NA|NA|NA S Acetyltransferase (GNAT) domain MAG.T1.121_00729 309801.trd_1847 5.5e-277 960.3 Thermomicrobia cutL 1.2.5.3 ko:K03520 R11168 RC02800 ko00000,ko01000 Bacteria 27XQT@189775,2G82V@200795,COG1529@1,COG1529@2 NA|NA|NA C Dehydrogenase MAG.T1.121_00730 365528.KB891208_gene3147 4.4e-10 71.2 Actinobacteria relA_2 2.7.4.1,2.7.6.5,3.1.7.2 ko:K00937,ko:K01139 ko00190,ko00230,ko03018,map00190,map00230,map03018 R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009,ko03019 Bacteria 2IHTX@201174,COG0317@1,COG0317@2 NA|NA|NA KT HD domain MAG.T1.121_00731 1121430.JMLG01000002_gene1082 9.8e-105 387.1 Peptococcaceae Bacteria 1TP54@1239,24AFB@186801,262E3@186807,COG1804@1,COG1804@2 NA|NA|NA C PFAM CoA-transferase family III MAG.T1.121_00732 717785.HYPMC_3447 2.7e-08 66.2 Alphaproteobacteria Bacteria 1RADI@1224,2E61I@1,2U5E9@28211,330QS@2 NA|NA|NA MAG.T1.121_00733 273068.TTE2386 7e-19 100.5 Thermoanaerobacterales mce 4.4.1.5,5.1.99.1,5.4.99.2 ko:K01759,ko:K01849,ko:K05606 ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00620,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R00833,R02530,R02765,R09979 RC00004,RC00395,RC00740,RC00780,RC02739 ko00000,ko00001,ko00002,ko01000 Bacteria 1V6SC@1239,24HPI@186801,42GK9@68295,COG0346@1,COG0346@2 NA|NA|NA E PFAM Glyoxalase bleomycin resistance protein dioxygenase MAG.T1.121_00734 1121090.KB894691_gene2556 8.1e-97 361.3 Bacillus ko:K02035 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 1TQ6S@1239,1ZKY2@1386,4HAM7@91061,COG0747@1,COG0747@2 NA|NA|NA E Bacterial extracellular solute-binding proteins, family 5 Middle MAG.T1.121_00735 1121090.KB894691_gene2555 2.1e-86 325.9 Bacillus dppB ko:K02033,ko:K13890 ko02010,ko02024,map02010,map02024 M00239,M00348 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.11 Bacteria 1TP1S@1239,1ZBXY@1386,4HBED@91061,COG0601@1,COG0601@2 NA|NA|NA EP COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components MAG.T1.121_00736 1499680.CCFE01000011_gene719 1.4e-79 303.1 Bacillus ko:K02034 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 1TP4R@1239,1ZKXZ@1386,4I3JS@91061,COG1173@1,COG1173@2 NA|NA|NA EP N-terminal TM domain of oligopeptide transport permease C MAG.T1.121_00737 1382356.JQMP01000004_gene645 1.1e-99 370.2 Thermomicrobia oppD ko:K02031,ko:K02032,ko:K15583 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 27XUE@189775,2G61B@200795,COG0444@1,COG0444@2 NA|NA|NA P Belongs to the ABC transporter superfamily MAG.T1.121_00738 1134413.ANNK01000172_gene492 3e-99 368.6 Bacillus ko:K02032,ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 1V36J@1239,1ZBA4@1386,4H9YB@91061,COG4608@1,COG4608@2 NA|NA|NA E Belongs to the ABC transporter superfamily MAG.T1.121_00739 479434.Sthe_0282 3.2e-105 388.7 Thermomicrobia 2.4.1.345 ko:K08256 R11702 ko00000,ko01000,ko01003 GT4 Bacteria 27XU5@189775,2G61C@200795,COG0438@1,COG0438@2 NA|NA|NA M Glycosyl transferase 4-like domain MAG.T1.121_00740 479434.Sthe_0281 1.1e-45 189.9 Thermomicrobia pgsA1 2.7.8.5 ko:K00995 ko00564,ko01100,map00564,map01100 R01801 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 Bacteria 27YAI@189775,2G6RT@200795,COG0558@1,COG0558@2 NA|NA|NA I Belongs to the CDP-alcohol phosphatidyltransferase class-I family MAG.T1.121_00742 479434.Sthe_2722 5.1e-29 134.4 Bacteria Bacteria COG0778@1,COG0778@2 NA|NA|NA C coenzyme F420-1:gamma-L-glutamate ligase activity MAG.T1.121_00743 644966.Tmar_0616 2.4e-90 339.3 Clostridia Bacteria 1UY29@1239,24C7S@186801,COG1063@1,COG1063@2 NA|NA|NA C Alcohol dehydrogenase zinc-binding domain protein MAG.T1.121_00744 479434.Sthe_0139 3.6e-109 401.7 Thermomicrobia 2.2.1.8,4.1.2.17 ko:K01628,ko:K18847 ko00051,ko01120,map00051,map01120 R02262 RC00603,RC00604 ko00000,ko00001,ko01000 Bacteria 27Y26@189775,2G8AX@200795,COG0235@1,COG0235@2 NA|NA|NA G Class II Aldolase and Adducin N-terminal domain MAG.T1.121_00745 479434.Sthe_0254 2.8e-77 295.4 Thermomicrobia nit ko:K11206 ko00000,ko01000 Bacteria 27XTA@189775,2G6KM@200795,COG0388@1,COG0388@2 NA|NA|NA S Carbon-nitrogen hydrolase MAG.T1.121_00746 479434.Sthe_1757 3e-07 61.2 Thermomicrobia ratA 3.5.1.104 ko:K21449,ko:K22278 ko00000,ko01000,ko02000 1.B.40.2 Bacteria 27Y1K@189775,2G95J@200795,COG1388@1,COG1388@2,COG4990@1,COG4990@2 NA|NA|NA M Peptidase_C39 like family MAG.T1.121_00747 1382356.JQMP01000001_gene881 1.6e-28 132.5 Thermomicrobia Bacteria 27Z7D@189775,2G72I@200795,COG3439@1,COG3439@2 NA|NA|NA S Domain of unknown function DUF302 MAG.T1.121_00748 929712.KI912613_gene2800 3.9e-14 84.3 Rubrobacteria Bacteria 2HFZ6@201174,4CQP4@84995,COG0607@1,COG0607@2 NA|NA|NA P Rhodanese Homology Domain MAG.T1.121_00749 525904.Tter_2720 1e-14 86.3 Bacteria Bacteria COG0607@1,COG0607@2 NA|NA|NA P Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS MAG.T1.121_00750 344747.PM8797T_10489 1.7e-95 356.7 Planctomycetes 3.1.2.6 ko:K01069 ko00620,map00620 R01736 RC00004,RC00137 ko00000,ko00001,ko01000 Bacteria 2IXEZ@203682,COG0491@1,COG0491@2,COG0607@1,COG0607@2 NA|NA|NA P COG0491 Zn-dependent MAG.T1.121_00751 309801.trd_A0630 5.9e-13 80.1 Bacteria ko:K21600 ko00000,ko03000 Bacteria COG1937@1,COG1937@2 NA|NA|NA S negative regulation of transcription, DNA-templated MAG.T1.121_00752 266779.Meso_1608 2.8e-160 572.0 Phyllobacteriaceae 3.6.3.17 ko:K10441 ko02010,map02010 M00212 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 Bacteria 1MU22@1224,2TQJV@28211,43H5X@69277,COG1129@1,COG1129@2 NA|NA|NA G Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system MAG.T1.121_00753 1122132.AQYH01000017_gene1048 5.1e-91 341.3 Rhizobiaceae ko:K10440 ko02010,map02010 M00212 ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 Bacteria 1NRTX@1224,2UQ6T@28211,4BEGF@82115,COG1172@1,COG1172@2 NA|NA|NA G Branched-chain amino acid transport system / permease component MAG.T1.121_00754 1122132.AQYH01000017_gene1049 6.8e-75 287.7 Rhizobiaceae ko:K10440 ko02010,map02010 M00212 ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 Bacteria 1NS06@1224,2UP77@28211,4BE45@82115,COG1172@1,COG1172@2 NA|NA|NA G Branched-chain amino acid transport system / permease component MAG.T1.121_00755 1382306.JNIM01000001_gene3213 3e-27 129.0 Bacteria gntR Bacteria COG1802@1,COG1802@2 NA|NA|NA K Transcriptional regulator MAG.T1.121_00756 1122132.AQYH01000017_gene1050 7.5e-104 384.0 Rhizobiaceae ko:K10439 ko02010,ko02030,map02010,map02030 M00212 ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 Bacteria 1NSI9@1224,2UQAX@28211,4BCRV@82115,COG1879@1,COG1879@2 NA|NA|NA G Periplasmic binding protein domain MAG.T1.121_00757 1122611.KB904018_gene6906 1.1e-105 391.0 Actinobacteria 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 Bacteria 2IF1J@201174,COG2414@1,COG2414@2 NA|NA|NA C Aldehyde ferredoxin oxidoreductase MAG.T1.121_00758 485913.Krac_10321 1.3e-148 532.7 Chloroflexi mdlA Bacteria 2G83T@200795,COG4948@1,COG4948@2 NA|NA|NA M PFAM Mandelate racemase muconate lactonizing MAG.T1.121_00759 479434.Sthe_3502 1.9e-95 355.9 Thermomicrobia GO:0000166,GO:0003674,GO:0003824,GO:0004657,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006560,GO:0006562,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016491,GO:0016645,GO:0019752,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0046483,GO:0046700,GO:0046983,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0071949,GO:0097159,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 ko:K00318 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 R10507 RC00083 ko00000,ko00001,ko01000 Bacteria 27XF7@189775,2G6B6@200795,COG0506@1,COG0506@2 NA|NA|NA C Proline dehydrogenase MAG.T1.121_00760 1382306.JNIM01000001_gene2318 1.7e-219 768.8 Bacteria 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 R03187 RC00632 ko00000,ko00001,ko01000 Bacteria COG0146@1,COG0146@2 NA|NA|NA EQ ligase activity MAG.T1.121_00761 264732.Moth_1967 4.6e-211 741.1 Thermoanaerobacterales oplaH 3.5.2.14,3.5.2.9 ko:K01469,ko:K01473 ko00330,ko00480,ko01100,map00330,map00480,map01100 R00251,R03187 RC00553,RC00632 ko00000,ko00001,ko01000 Bacteria 1TQVB@1239,24AJ7@186801,42HNB@68295,COG0145@1,COG0145@2 NA|NA|NA EQ Hydantoinase/oxoprolinase N-terminal region MAG.T1.121_00762 266117.Rxyl_0096 1.4e-49 203.4 Rubrobacteria dapB GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.17.1.8 ko:K00215,ko:K03546 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000,ko03400 iIT341.HP0510,iLJ478.TM1520,iSbBS512_1146.SbBS512_E0035 Bacteria 2GM2T@201174,4CQJH@84995,COG0289@1,COG0289@2 NA|NA|NA E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate MAG.T1.121_00763 639282.DEFDS_0215 1.6e-78 299.7 Deferribacteres dapA 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 Bacteria 2GF1R@200930,COG0329@1,COG0329@2 NA|NA|NA H Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) MAG.T1.121_00764 1382356.JQMP01000003_gene2449 2.5e-07 62.4 Thermomicrobia GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.7.2.1 ko:K00368,ko:K18683 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 Bacteria 27YMB@189775,2GA6H@200795,COG4454@1,COG4454@2 NA|NA|NA P Copper binding proteins, plastocyanin/azurin family MAG.T1.121_00765 479434.Sthe_0903 0.0 1133.6 Thermomicrobia helY GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575 ko:K03727 ko00000,ko01000 Bacteria 27XJ5@189775,2G7P6@200795,COG4581@1,COG4581@2 NA|NA|NA L DSHCT MAG.T1.121_00766 479434.Sthe_0904 1.5e-78 300.1 Thermomicrobia Bacteria 27XVU@189775,2G5PS@200795,COG0438@1,COG0438@2 NA|NA|NA M Glycosyl transferase 4-like domain MAG.T1.121_00767 479434.Sthe_0905 3.4e-61 242.3 Thermomicrobia thiL GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009030,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009229,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0035639,GO:0036094,GO:0042357,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 iSFV_1184.SFV_0382,iYO844.BSU05900 Bacteria 27XMF@189775,2G6SH@200795,COG0611@1,COG0611@2 NA|NA|NA H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 MAG.T1.121_00768 1340493.JNIF01000003_gene2712 6.9e-43 181.0 Acidobacteria 4.1.2.20,4.1.2.52 ko:K01630,ko:K02510 ko00053,ko00350,ko01120,map00053,map00350,map01120 R01645,R01647,R02754,R03277 RC00307,RC00435,RC00572,RC00574,RC03057 ko00000,ko00001,ko01000 Bacteria 3Y5ZN@57723,COG3836@1,COG3836@2 NA|NA|NA G Belongs to the HpcH HpaI aldolase family MAG.T1.121_00769 196162.Noca_0038 5.2e-72 277.7 Propionibacteriales Bacteria 2I8VQ@201174,4DV5W@85009,COG0684@1,COG0684@2 NA|NA|NA H Aldolase/RraA MAG.T1.121_00770 525904.Tter_1923 2.8e-80 305.4 unclassified Bacteria glxR GO:0000255,GO:0000256,GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008679,GO:0009056,GO:0009436,GO:0009442,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0019752,GO:0032787,GO:0033554,GO:0034641,GO:0042737,GO:0043436,GO:0043603,GO:0043605,GO:0044237,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046185,GO:0046395,GO:0046483,GO:0046487,GO:0046700,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0072329,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 1.1.1.31,1.1.1.60 ko:K00020,ko:K00042 ko00280,ko00630,ko01100,map00280,map00630,map01100 R01745,R01747,R05066 RC00099 ko00000,ko00001,ko01000 Bacteria 2NQRW@2323,COG2084@1,COG2084@2 NA|NA|NA I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase MAG.T1.121_00771 1502852.FG94_04625 5e-65 254.6 Oxalobacteraceae hyi 5.3.1.22 ko:K01816 ko00630,ko01100,map00630,map01100 R01394 RC00511 ko00000,ko00001,ko01000 Bacteria 1MV53@1224,2VJ19@28216,475T9@75682,COG3622@1,COG3622@2 NA|NA|NA G Xylose isomerase-like TIM barrel MAG.T1.121_00773 1121946.AUAX01000027_gene7931 6.1e-105 388.3 Micromonosporales Bacteria 2GIUM@201174,4D9JZ@85008,COG0477@1,COG0477@2 NA|NA|NA EGP Major Facilitator Superfamily MAG.T1.121_00774 573370.DMR_22100 1.7e-12 79.3 Desulfovibrionales Bacteria 1NI1U@1224,2MBMC@213115,2WSPF@28221,42XXC@68525,COG1846@1,COG1846@2 NA|NA|NA K Regulatory protein MarR MAG.T1.121_00775 351160.RCIX333 1e-25 124.0 Methanomicrobia pgiA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 5.3.1.9 ko:K06859 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000 Archaea 2N9IM@224756,2XWS8@28890,COG2140@1,arCOG02602@2157 NA|NA|NA G PFAM Glucose-6-phosphate isomerase MAG.T1.121_00776 1121012.AUKX01000053_gene2565 4.1e-29 134.8 Arenibacter rmpB 5.3.1.27 ko:K08094 ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230 M00345,M00580 R05339,R09780 RC00377 ko00000,ko00001,ko00002,ko01000 Bacteria 1I2BR@117743,23I2R@178469,4NNU3@976,COG0794@1,COG0794@2 NA|NA|NA M SIS domain MAG.T1.121_00777 1159488.SEQMU2_14820 1.5e-19 103.2 Staphylococcaceae hxlA GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.2.43 ko:K08093 ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230 M00345,M00580 R05338 RC00421,RC00422 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQ55@1239,4GXBF@90964,4HBMT@91061,COG0269@1,COG0269@2 NA|NA|NA G Catalyzes the condensation of ribulose 5-phosphate with formaldehyde to form 3-hexulose 6-phosphate MAG.T1.121_00778 1223523.H340_31048 4.2e-84 318.9 Actinobacteria Bacteria 2IEF4@201174,COG0596@1,COG0596@2 NA|NA|NA S TAP-like protein MAG.T1.121_00779 32057.KB217478_gene616 8e-77 295.0 Cyanobacteria Bacteria 1G7IV@1117,COG0596@1,COG0596@2 NA|NA|NA S TAP-like protein MAG.T1.121_00782 479434.Sthe_1549 1.6e-127 462.6 Thermomicrobia asd GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016620,GO:0016903,GO:0030312,GO:0036094,GO:0040007,GO:0043891,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071944,GO:0097159,GO:1901265,GO:1901363 1.2.1.11,1.2.1.12 ko:K00133,ko:K00134 ko00010,ko00260,ko00261,ko00270,ko00300,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04066,ko05010,map00010,map00260,map00261,map00270,map00300,map00710,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04066,map05010 M00001,M00002,M00003,M00016,M00017,M00018,M00033,M00165,M00166,M00308,M00525,M00526,M00527,M00552 R01061,R02291 RC00149,RC00684 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 Bacteria 27XNM@189775,2G5T9@200795,COG0136@1,COG0136@2 NA|NA|NA C Belongs to the aspartate-semialdehyde dehydrogenase family MAG.T1.121_00783 357808.RoseRS_3079 8.6e-79 301.2 Chloroflexia 1.1.1.3,2.7.2.4 ko:K00928,ko:K12524 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480,R01773,R01775 RC00002,RC00043,RC00087 ko00000,ko00001,ko00002,ko01000 Bacteria 2G5U9@200795,37577@32061,COG0527@1,COG0527@2 NA|NA|NA E PFAM aspartate glutamate uridylate kinase MAG.T1.121_00786 317936.Nos7107_1719 1.8e-28 133.3 Bacteria Bacteria 2ERTE@1,33JCN@2 NA|NA|NA MAG.T1.121_00787 479434.Sthe_2752 7.5e-71 275.0 Thermomicrobia epsB 2.7.10.1,2.7.10.2 ko:K08252,ko:K08253,ko:K16554,ko:K16692 ko05111,map05111 ko00000,ko00001,ko01000,ko01001,ko02000 8.A.3.1 Bacteria 27Y7Y@189775,2G5WM@200795,COG0489@1,COG0489@2,COG3206@1,COG3206@2,COG3944@1,COG3944@2 NA|NA|NA DM Capsular exopolysaccharide family MAG.T1.121_00788 485913.Krac_7830 2e-86 326.2 Chloroflexi wcnD Bacteria 2G683@200795,COG0438@1,COG0438@2 NA|NA|NA M PFAM glycosyl transferase group 1 MAG.T1.121_00790 1123320.KB889667_gene2949 2e-61 242.7 Actinobacteria Bacteria 2GIXX@201174,COG1119@1,COG1119@2 NA|NA|NA P ABC transporter MAG.T1.121_00792 1444306.JFZC01000099_gene1162 2.4e-40 173.7 Bacilli entD 3.2.1.96,3.4.17.14,6.1.1.12 ko:K01227,ko:K01876,ko:K07260,ko:K11060,ko:K21472 ko00511,ko00550,ko00970,ko01100,ko01502,ko02020,map00511,map00550,map00970,map01100,map01502,map02020 M00359,M00360,M00651 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01002,ko01007,ko01011,ko01504,ko02042,ko03016,ko03029 Bacteria 1V4UU@1239,4HK14@91061,COG3103@1,COG3103@2,COG3807@1,COG3807@2 NA|NA|NA MT Bacterial SH3 domain MAG.T1.121_00793 867845.KI911784_gene77 5.7e-90 337.8 Chloroflexia ko:K03924 ko00000,ko01000 Bacteria 2G669@200795,376UU@32061,COG0714@1,COG0714@2 NA|NA|NA S ATPase associated with various cellular activities, AAA_3 MAG.T1.121_00794 479434.Sthe_2125 1.8e-72 280.0 Thermomicrobia Bacteria 27YYN@189775,2G6Y7@200795,COG1721@1,COG1721@2 NA|NA|NA S Protein of unknown function DUF58 MAG.T1.121_00795 479434.Sthe_2124 4.6e-40 172.6 Thermomicrobia Bacteria 27Z1X@189775,2DTHQ@1,2G7BU@200795,33KDI@2 NA|NA|NA S Domain of unknown function (DUF4129) MAG.T1.121_00798 479434.Sthe_1268 5.4e-34 151.8 Thermomicrobia Bacteria 27Z6N@189775,2GBEQ@200795,COG4454@1,COG4454@2 NA|NA|NA MAG.T1.121_00799 1303692.SFUL_4252 9.6e-16 89.7 Actinobacteria Bacteria 2IKVV@201174,COG4994@1,COG4994@2 NA|NA|NA J Domain of unknown function (DUF4440) MAG.T1.121_00800 272942.RCAP_rcc01019 1.3e-75 290.0 Rhodobacter 3.1.3.97 ko:K07053 R00188,R11188 RC00078 ko00000,ko01000 Bacteria 1FATD@1060,1PBDI@1224,2U1HY@28211,COG0613@1,COG0613@2 NA|NA|NA S DNA polymerase alpha chain like domain MAG.T1.121_00801 449447.MAE_62380 7.7e-18 96.7 Bacteria ko:K07171 ko00000,ko01000,ko02048 Bacteria COG2337@1,COG2337@2 NA|NA|NA T Toxic component of a toxin-antitoxin (TA) module MAG.T1.121_00803 266117.Rxyl_0405 2.7e-99 368.6 Actinobacteria ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GJ84@201174,COG1131@1,COG1131@2 NA|NA|NA V ABC transporter MAG.T1.121_00804 266117.Rxyl_0406 2.6e-91 342.0 Actinobacteria ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GSKI@201174,COG0842@1,COG0842@2 NA|NA|NA V ABC-2 type transporter MAG.T1.121_00805 655815.ZPR_4568 1.6e-134 486.9 Flavobacteriia pepO 3.4.24.71 ko:K01415,ko:K07386 ko00000,ko01000,ko01002,ko04147 Bacteria 1HX3E@117743,4NEYB@976,COG3590@1,COG3590@2 NA|NA|NA O peptidase family M13 MAG.T1.121_00808 101510.RHA1_ro01226 6.3e-46 191.4 Nocardiaceae Bacteria 2IAVM@201174,4G8K9@85025,COG0596@1,COG0596@2 NA|NA|NA S Alpha/beta hydrolase family MAG.T1.121_00809 1320556.AVBP01000013_gene1672 4.5e-78 298.1 Phyllobacteriaceae ko:K02034 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 1NMV0@1224,2TT6Y@28211,43HZV@69277,COG1173@1,COG1173@2 NA|NA|NA EP COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components MAG.T1.121_00810 1231190.NA8A_18637 1e-96 360.1 Phyllobacteriaceae ko:K02033 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 1MU8Z@1224,2TR0N@28211,43IS8@69277,COG0601@1,COG0601@2 NA|NA|NA EP COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components MAG.T1.121_00811 1231185.BAMP01000073_gene3382 7e-159 567.4 Phyllobacteriaceae ko:K02035 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 1PUV0@1224,2TVJT@28211,43J4C@69277,COG0747@1,COG0747@2 NA|NA|NA E ABC-type dipeptide transport system periplasmic component MAG.T1.121_00812 316067.Geob_2502 4.8e-18 97.8 Bacteria Bacteria COG0454@1,COG0456@2 NA|NA|NA K acetyltransferase MAG.T1.121_00813 926550.CLDAP_32020 8.8e-98 364.0 Chloroflexi anmK GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0044237 2.7.1.170,4.2.1.126 ko:K07106,ko:K09001 ko00520,ko01100,map00520,map01100 R08555 RC00397,RC00746 ko00000,ko00001,ko01000 iECABU_c1320.ECABU_c18930,iECED1_1282.ECED1_1841,ic_1306.c2032 Bacteria 2G7X8@200795,COG2377@1,COG2377@2 NA|NA|NA F Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling MAG.T1.121_00814 1380370.JIBA01000015_gene142 4.9e-07 60.8 Intrasporangiaceae Bacteria 2INIM@201174,4FH3P@85021,COG5646@1,COG5646@2 NA|NA|NA S Domain of unknown function (DU1801) MAG.T1.121_00815 402777.KB235906_gene355 1.3e-23 116.3 Oscillatoriales Bacteria 1G9ZV@1117,1HDMM@1150,COG0662@1,COG0662@2 NA|NA|NA G Lipocalin-like domain MAG.T1.121_00816 1123258.AQXZ01000018_gene415 2.5e-28 131.7 Actinobacteria ko:K14673 ko00000,ko01008 Bacteria 2IRGP@201174,COG0662@1,COG0662@2 NA|NA|NA G Cupin 2, conserved barrel domain protein MAG.T1.121_00817 479434.Sthe_2331 3e-75 288.9 Thermomicrobia Bacteria 27XIS@189775,2G826@200795,2ZJ84@2,KOG2524@1 NA|NA|NA S Potential Queuosine, Q, salvage protein family MAG.T1.121_00820 1033730.CAHG01000016_gene364 1.3e-45 189.9 Propionibacteriales Bacteria 2HRC6@201174,4DUDX@85009,COG1280@1,COG1280@2 NA|NA|NA E Sap, sulfolipid-1-addressing protein MAG.T1.121_00823 1317124.DW2_15285 9.9e-77 293.1 Thioclava gyrB GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 ko:K02470 ko00000,ko01000,ko03032,ko03400 Bacteria 1MVKT@1224,2TRBK@28211,2XN2F@285107,COG0187@1,COG0187@2 NA|NA|NA L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner MAG.T1.121_00824 479434.Sthe_1168 4.9e-20 103.6 Thermomicrobia ko:K03530,ko:K05787 ko00000,ko03032,ko03036,ko03400 Bacteria 27YJY@189775,2G7G2@200795,COG0776@1,COG0776@2 NA|NA|NA L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions MAG.T1.121_00825 309801.trd_0830 1.3e-37 163.3 Thermomicrobia spoU 2.1.1.185,2.1.1.34 ko:K00556,ko:K03218,ko:K03437 ko00000,ko01000,ko03009,ko03016 Bacteria 27YC9@189775,2G6MC@200795,COG0566@1,COG0566@2 NA|NA|NA J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family MAG.T1.121_00826 316274.Haur_4638 4.4e-32 144.1 Chloroflexia rplT GO:0000027,GO:0000900,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0060255,GO:0065003,GO:0065007,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090079,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2000113,GO:2001141 ko:K02887 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2G6V4@200795,375NZ@32061,COG0292@1,COG0292@2 NA|NA|NA J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit MAG.T1.121_00827 525904.Tter_0767 1.1e-11 75.5 Bacteria rpmI GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 ko:K02916 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria COG0291@1,COG0291@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL35 family MAG.T1.121_00828 479434.Sthe_1172 2.6e-48 198.4 Thermomicrobia infC GO:0000049,GO:0001731,GO:0002181,GO:0002183,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006417,GO:0006446,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016020,GO:0016043,GO:0019222,GO:0019538,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032268,GO:0032270,GO:0032790,GO:0032984,GO:0032988,GO:0032991,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043254,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045727,GO:0045948,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065003,GO:0065007,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901193,GO:1901195,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:1904688,GO:1904690,GO:1990856,GO:1990904,GO:2000112,GO:2000765,GO:2000767 ko:K02520 ko00000,ko03012,ko03029 Bacteria 27YJM@189775,2G6N2@200795,COG0290@1,COG0290@2 NA|NA|NA J Translation initiation factor IF-3, C-terminal domain MAG.T1.121_00829 309801.trd_0769 5e-59 235.0 Thermomicrobia ribF GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008531,GO:0009058,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009124,GO:0009156,GO:0009161,GO:0009165,GO:0009231,GO:0009259,GO:0009260,GO:0009398,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0034654,GO:0042364,GO:0042726,GO:0042727,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046390,GO:0046444,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 27XW5@189775,2G6JF@200795,COG0196@1,COG0196@2 NA|NA|NA H Riboflavin kinase MAG.T1.121_00830 479434.Sthe_1260 2.2e-59 236.1 Thermomicrobia truB GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 ko:K03177 ko00000,ko01000,ko03016 Bacteria 27XEP@189775,2G6F4@200795,COG0130@1,COG0130@2 NA|NA|NA J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs MAG.T1.121_00831 479434.Sthe_1259 4.3e-69 268.5 Thermomicrobia nrnA GO:0008150,GO:0040007 2.7.7.72,3.1.13.3,3.1.3.7 ko:K00974,ko:K06881 ko00920,ko01100,ko01120,ko03013,map00920,map01100,map01120,map03013 R00188,R00508,R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016,ko03400 Bacteria 27Y2D@189775,2G6RF@200795,COG0618@1,COG0618@2 NA|NA|NA S DHH family MAG.T1.121_00832 479434.Sthe_1258 3.2e-25 121.3 Thermomicrobia rbfA GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0030490,GO:0033554,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043021,GO:0043024,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071840,GO:0090304,GO:1901360 ko:K02834 ko00000,ko03009 Bacteria 27YJU@189775,2G73E@200795,COG0858@1,COG0858@2 NA|NA|NA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA MAG.T1.121_00833 479434.Sthe_1257 1.6e-226 792.3 Thermomicrobia infB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 ko:K02519 ko00000,ko03012,ko03029 Bacteria 27XWF@189775,2G5UR@200795,COG0532@1,COG0532@2 NA|NA|NA J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex MAG.T1.121_00834 479434.Sthe_1256 5.4e-22 110.5 Thermomicrobia ylxR ko:K02600,ko:K07742 ko00000,ko03009,ko03021 Bacteria 27YHF@189775,2G72H@200795,COG2740@1,COG2740@2 NA|NA|NA K Protein of unknown function (DUF448) MAG.T1.121_00835 479434.Sthe_1255 5.1e-179 634.0 Thermomicrobia nusA GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0040007,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 ko:K02600 ko00000,ko03009,ko03021 Bacteria 27XPJ@189775,2G5M5@200795,COG0195@1,COG0195@2 NA|NA|NA K Participates in both transcription termination and antitermination MAG.T1.121_00836 479434.Sthe_1254 2e-125 456.1 Thermomicrobia ybhK Bacteria 27XU0@189775,2G5MJ@200795,COG0391@1,COG0391@2 NA|NA|NA S Required for morphogenesis under gluconeogenic growth conditions MAG.T1.121_00837 479434.Sthe_1253 8.8e-38 164.5 Thermomicrobia gap 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 Bacteria 27Y38@189775,2G5MG@200795,COG0057@1,COG0057@2 NA|NA|NA C Belongs to the glyceraldehyde-3-phosphate dehydrogenase family MAG.T1.121_00838 1128421.JAGA01000002_gene559 4.6e-123 448.0 unclassified Bacteria pgk GO:0001871,GO:0002020,GO:0003674,GO:0003824,GO:0004618,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009893,GO:0009986,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016020,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019222,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030162,GO:0030193,GO:0030195,GO:0030246,GO:0030247,GO:0030312,GO:0031323,GO:0031325,GO:0032101,GO:0032102,GO:0032268,GO:0032270,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0043532,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048518,GO:0048519,GO:0048522,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0050818,GO:0050819,GO:0050878,GO:0051171,GO:0051173,GO:0051186,GO:0051188,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051917,GO:0051919,GO:0055086,GO:0060255,GO:0061041,GO:0061045,GO:0065007,GO:0065008,GO:0070613,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0080134,GO:0090407,GO:1900046,GO:1900047,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903034,GO:1903035,GO:1903317,GO:1903319,GO:2001065 2.7.2.3,5.3.1.1 ko:K00927,ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01015,R01512 RC00002,RC00043,RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 iSB619.SA_RS04145,iSbBS512_1146.SbBS512_E3351 Bacteria 2NNN1@2323,COG0126@1,COG0126@2 NA|NA|NA G Belongs to the phosphoglycerate kinase family MAG.T1.121_00839 479434.Sthe_1251 2.5e-58 232.3 Thermomicrobia tpiA GO:0003674,GO:0003824,GO:0004807,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009758,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016854,GO:0016857,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 2.7.2.3,5.1.3.39,5.3.1.1,5.3.1.33 ko:K00927,ko:K01803,ko:K20905,ko:K21910 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01015,R01512 RC00002,RC00043,RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 iHN637.CLJU_RS19265,iJN746.PP_4715 Bacteria 27Y7X@189775,2G69W@200795,COG0149@1,COG0149@2 NA|NA|NA G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) MAG.T1.121_00840 479434.Sthe_1250 2.7e-08 64.3 Thermomicrobia secG GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 Bacteria 27YMZ@189775,2G7D9@200795,COG1314@1,COG1314@2 NA|NA|NA U Preprotein translocase SecG subunit MAG.T1.121_00841 309801.trd_0347 1.5e-105 389.8 Thermomicrobia coaBC 4.1.1.36,6.3.2.5 ko:K13038,ko:K21977 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 Bacteria 27XWG@189775,2G60D@200795,COG0452@1,COG0452@2 NA|NA|NA H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine MAG.T1.121_00844 479434.Sthe_1023 3.2e-44 185.7 Thermomicrobia Bacteria 27YF1@189775,2G77V@200795,COG1597@1,COG1597@2 NA|NA|NA I Diacylglycerol kinase catalytic domain MAG.T1.121_00845 479434.Sthe_1022 2.7e-30 139.4 Thermomicrobia ko:K15539 ko00000 Bacteria 27XWE@189775,2G773@200795,COG1426@1,COG1426@2 NA|NA|NA S Helix-turn-helix domain MAG.T1.121_00846 479434.Sthe_1021 4.4e-24 119.8 Thermomicrobia Bacteria 27YI2@189775,2BQKE@1,2GBAE@200795,32JGF@2 NA|NA|NA MAG.T1.121_00848 479434.Sthe_1020 2.4e-163 582.0 Thermomicrobia miaB GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035597,GO:0035600,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360 2.8.4.3 ko:K06168 R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 Bacteria 27Y2T@189775,2G5QK@200795,COG0621@1,COG0621@2 NA|NA|NA H Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine MAG.T1.121_00849 479434.Sthe_1019 1.6e-37 163.3 Chloroflexi Bacteria 2G6Q2@200795,COG0457@1,COG0457@2 NA|NA|NA S PFAM TPR repeat-containing protein MAG.T1.121_00851 1040986.ATYO01000003_gene5856 7e-07 60.1 Phyllobacteriaceae Bacteria 1MZCY@1224,2UC5S@28211,43KSD@69277,COG3339@1,COG3339@2 NA|NA|NA S Protein of unknown function (DUF1232) MAG.T1.121_00852 479434.Sthe_1016 2.6e-19 102.4 Thermomicrobia mobA 2.7.7.77 ko:K03752 ko00790,ko01100,map00790,map01100 R11581 ko00000,ko00001,ko01000 Bacteria 27Y9U@189775,2G786@200795,COG0746@1,COG0746@2 NA|NA|NA H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor MAG.T1.121_00853 1382356.JQMP01000003_gene2387 4e-22 110.5 Thermomicrobia Bacteria 27YJS@189775,2EAGR@1,2G730@200795,334K0@2 NA|NA|NA S PFAM zinc finger, SWIM domain protein MAG.T1.121_00854 479434.Sthe_1013 1.1e-22 112.8 Bacteria Bacteria COG3870@1,COG3870@2 NA|NA|NA S Cyclic-di-AMP receptor MAG.T1.121_00855 479434.Sthe_1012 2e-50 206.1 Bacteria 3.5.2.10 ko:K01470 ko00330,map00330 R01884 RC00615 ko00000,ko00001,ko01000 Bacteria COG1402@1,COG1402@2 NA|NA|NA I creatininase MAG.T1.121_00856 1118054.CAGW01000081_gene2691 7.7e-116 424.1 Bacilli ko:K09123,ko:K09128 ko00000 Bacteria 1UJDG@1239,4HTS5@91061,COG1679@1,COG1679@2,COG1786@1,COG1786@2 NA|NA|NA S Protein of unknown function (DUF521) MAG.T1.121_00857 1038922.PflQ2_3122 2.6e-28 131.7 Pseudomonas fluorescens group ko:K09123,ko:K09128 ko00000 Bacteria 1NFH4@1224,1S4TW@1236,1YQ32@136843,COG1679@1,COG1679@2,COG1786@1,COG1786@2 NA|NA|NA S Protein of unknown function (DUF521) MAG.T1.121_00858 525904.Tter_0192 8.7e-108 397.1 unclassified Bacteria leuB GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2NP1R@2323,COG0473@1,COG0473@2 NA|NA|NA CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate MAG.T1.121_00859 471852.Tcur_3462 1.1e-61 243.0 Streptosporangiales leuD GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016020,GO:0016053,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 iNJ661.Rv2987c Bacteria 2GJ8Z@201174,4EIT7@85012,COG0066@1,COG0066@2 NA|NA|NA E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate MAG.T1.121_00860 351607.Acel_1591 9.7e-200 703.0 Frankiales leuC GO:0003674,GO:0003824,GO:0003861,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009316,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0019752,GO:0030312,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 iEcE24377_1341.EcE24377A_0075,iPC815.YPO0531 Bacteria 2GKT7@201174,4ERE0@85013,COG0065@1,COG0065@2 NA|NA|NA E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate MAG.T1.121_00861 479434.Sthe_0763 1.1e-156 560.1 Thermomicrobia leuA 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS10690,iYO844.BSU28280 Bacteria 27XS3@189775,2G5V9@200795,COG0119@1,COG0119@2 NA|NA|NA E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) MAG.T1.121_00862 309801.trd_0625 3.1e-128 464.9 Thermomicrobia ilvC GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004455,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0022607,GO:0036094,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 iEC042_1314.EC042_4152,iECABU_c1320.ECABU_c42560,iECED1_1282.ECED1_4460,iECO103_1326.ECO103_4390,iECO111_1330.ECO111_4600,iECO26_1355.ECO26_4812,iECP_1309.ECP_3967,iECSE_1348.ECSE_4057,iECUMN_1333.ECUMN_4300,iEcE24377_1341.EcE24377A_4285,iEcSMS35_1347.EcSMS35_4140,iHN637.CLJU_RS07505,iHN637.CLJU_RS10005,iHN637.CLJU_RS10010,iIT341.HP0330,iJN746.PP_4678,iLF82_1304.LF82_1103,iLJ478.TM0550 Bacteria 27XV8@189775,2G5NP@200795,COG0059@1,COG0059@2 NA|NA|NA H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate MAG.T1.121_00863 479434.Sthe_1556 6.1e-46 190.7 Thermomicrobia ilvN 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 Bacteria 27Y6I@189775,2G6NW@200795,COG0440@1,COG0440@2 NA|NA|NA E ACT domain MAG.T1.121_00864 479434.Sthe_1557 2.8e-185 655.2 Thermomicrobia ilvB 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 Bacteria 27XQ6@189775,2G5Q7@200795,COG0028@1,COG0028@2 NA|NA|NA H Thiamine pyrophosphate enzyme, central domain MAG.T1.121_00865 479434.Sthe_1677 9.1e-20 104.0 Thermomicrobia ko:K09017 ko00000,ko03000 Bacteria 27Z5B@189775,2G8XR@200795,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family MAG.T1.121_00866 235985.BBPN01000037_gene580 4.3e-172 611.3 Streptacidiphilus Bacteria 2GJ09@201174,2NH2M@228398,COG0477@1,COG0477@2 NA|NA|NA EGP Sugar (and other) transporter MAG.T1.121_00867 42256.RradSPS_2444 2.4e-84 318.9 Rubrobacteria 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 Bacteria 2GMDR@201174,4CPB2@84995,COG2897@1,COG2897@2 NA|NA|NA P Rhodanese Homology Domain MAG.T1.121_00868 266117.Rxyl_2051 0.0 1107.0 Actinobacteria 3.2.1.170,3.2.1.24 ko:K01191,ko:K15524 ko00511,map00511 ko00000,ko00001,ko01000,ko04131 GH38 Bacteria 2GM02@201174,COG0383@1,COG0383@2 NA|NA|NA G PFAM Glycoside hydrolase, family 38 MAG.T1.121_00869 679926.Mpet_0265 5.9e-26 124.8 Methanomicrobia GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0042802,GO:0044464,GO:0071944 ko:K10716 ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 Archaea 2NADN@224756,2Y19J@28890,COG1226@1,arCOG01964@2157 NA|NA|NA P Ion channel MAG.T1.121_00873 1144313.PMI10_03051 1.5e-38 167.2 Bacteria Bacteria COG2152@1,COG2152@2 NA|NA|NA G transferase activity, transferring glycosyl groups MAG.T1.121_00878 1382356.JQMP01000001_gene1211 6e-20 104.4 Thermomicrobia asnC ko:K03718,ko:K03719 ko00000,ko03000,ko03036 Bacteria 27YBX@189775,2G77K@200795,COG1522@1,COG1522@2 NA|NA|NA K Transcription regulator MAG.T1.121_00879 1382356.JQMP01000004_gene543 1e-38 167.5 Thermomicrobia ratA 3.5.1.104 ko:K21449,ko:K22278 ko00000,ko01000,ko02000 1.B.40.2 Bacteria 27Y1K@189775,2G95J@200795,COG1388@1,COG1388@2,COG4990@1,COG4990@2 NA|NA|NA M Peptidase_C39 like family MAG.T1.121_00880 479434.Sthe_3080 4.3e-105 388.3 Thermomicrobia hdaH Bacteria 27YZ1@189775,2G5X3@200795,COG0123@1,COG0123@2 NA|NA|NA BQ Histone deacetylase domain MAG.T1.121_00882 1408424.JHYI01000004_gene3449 1.5e-65 256.5 Bacillus mntC ko:K09819,ko:K19976 ko02010,map02010 M00243,M00792 ko00000,ko00001,ko00002,ko02000 3.A.1.15,3.A.1.15.15 Bacteria 1TPZB@1239,1ZAY6@1386,4HBD7@91061,COG1108@1,COG1108@2 NA|NA|NA P 'COG1108 ABC-type Mn2 Zn2 transport systems, permease components' MAG.T1.121_00883 357808.RoseRS_3069 1.8e-54 219.5 Chloroflexia mntB ko:K09820,ko:K11710,ko:K16786,ko:K16787 ko02010,map02010 M00243,M00319,M00582 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.15,3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 iYO844.BSU30760 Bacteria 2G5WQ@200795,374U1@32061,COG1121@1,COG1121@2 NA|NA|NA P PFAM ABC transporter related MAG.T1.121_00884 1128421.JAGA01000003_gene3096 3.5e-57 228.8 unclassified Bacteria ko:K02077,ko:K09818 M00243,M00244 ko00000,ko00002,ko02000 3.A.1.15 Bacteria 2NP5U@2323,COG0803@1,COG0803@2 NA|NA|NA P Zinc-uptake complex component A periplasmic MAG.T1.121_00885 316274.Haur_4545 1.1e-26 126.3 Chloroflexia ko:K03711 ko00000,ko03000 Bacteria 2G74Y@200795,375U6@32061,COG0735@1,COG0735@2 NA|NA|NA P Belongs to the Fur family MAG.T1.121_00886 1128421.JAGA01000001_gene2344 1.8e-77 297.4 unclassified Bacteria yciQ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 2NQC3@2323,COG4907@1,COG4907@2 NA|NA|NA S Predicted membrane protein (DUF2207) MAG.T1.121_00887 479434.Sthe_1747 3.8e-43 181.8 Thermomicrobia rffM 2.4.1.187 ko:K05946 ko05111,map05111 ko00000,ko00001,ko01000,ko01003 GT26 Bacteria 27Y7Q@189775,2G6J0@200795,COG1922@1,COG1922@2 NA|NA|NA M Belongs to the glycosyltransferase 26 family MAG.T1.121_00888 479434.Sthe_1748 1.3e-43 183.0 Thermomicrobia Bacteria 27YJ3@189775,2G79Z@200795,COG3063@1,COG3063@2 NA|NA|NA NU Type IV pilus biogenesis stability protein PilW MAG.T1.121_00889 309801.trd_1843 3.6e-97 362.5 Thermomicrobia murJ GO:0003674,GO:0005215,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0008150,GO:0015238,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0042221,GO:0042493,GO:0042891,GO:0042895,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944 ko:K03980 ko00000,ko01011,ko02000 2.A.66.4 Bacteria 27Y0W@189775,2G5PF@200795,COG0728@1,COG0728@2 NA|NA|NA S MviN-like protein MAG.T1.121_00890 309801.trd_0315 1.8e-101 376.3 Chloroflexi larC 4.99.1.12 ko:K06898,ko:K09121 ko00000,ko01000 Bacteria 2G5MP@200795,COG1641@1,COG1641@2 NA|NA|NA S Belongs to the LarC family MAG.T1.121_00891 479434.Sthe_2593 8.1e-80 303.9 Thermomicrobia 3.5.3.6 ko:K01478 ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130 R00552 RC00177 ko00000,ko00001,ko01000 Bacteria 27YZU@189775,2G7QT@200795,COG1834@1,COG1834@2 NA|NA|NA E Amidinotransferase MAG.T1.121_00892 1487953.JMKF01000006_gene5674 2.2e-69 269.6 Oscillatoriales ko:K02055,ko:K11069 ko02010,ko02024,map02010,map02024 M00193,M00299 ko00000,ko00001,ko00002,ko02000 3.A.1.11,3.A.1.11.1 Bacteria 1G0DM@1117,1H8MN@1150,COG0687@1,COG0687@2 NA|NA|NA E Spermidine putrescine-binding periplasmic protein MAG.T1.121_00893 1173026.Glo7428_2470 2.5e-73 282.3 Cyanobacteria ydcU GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02054,ko:K11071 ko02010,ko02024,map02010,map02024 M00193,M00299 ko00000,ko00001,ko00002,ko02000 3.A.1.11,3.A.1.11.1 iEcSMS35_1347.EcSMS35_1732 Bacteria 1G127@1117,COG1176@1,COG1176@2 NA|NA|NA P ABC-type spermidine putrescine transport system, permease component I MAG.T1.121_00894 1173026.Glo7428_2471 6.5e-58 231.1 Cyanobacteria ydcV GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0009290,GO:0009292,GO:0009294,GO:0009987,GO:0015931,GO:0016020,GO:0044464,GO:0044764,GO:0050657,GO:0051027,GO:0051179,GO:0051234,GO:0051704,GO:0071702,GO:0071705,GO:0071944,GO:0098657 ko:K02053,ko:K11070 ko02010,ko02024,map02010,map02024 M00193,M00299 ko00000,ko00001,ko00002,ko02000 3.A.1.11,3.A.1.11.1 iEC55989_1330.EC55989_1575,iECIAI1_1343.ECIAI1_1439,iECO111_1330.ECO111_1832,iECO26_1355.ECO26_2042,iECW_1372.ECW_m1571,iECs_1301.ECs2047,iEKO11_1354.EKO11_2376,iUMNK88_1353.UMNK88_1846,iWFL_1372.ECW_m1571,iZ_1308.Z2276,ic_1306.c1867 Bacteria 1G1B6@1117,COG1177@1,COG1177@2 NA|NA|NA P ABC-type spermidine putrescine transport system, permease component II MAG.T1.121_00895 926550.CLDAP_37530 2.1e-104 386.0 Chloroflexi potA 3.6.3.31 ko:K11072 ko02010,map02010 M00299 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.11.1 Bacteria 2G62V@200795,COG3842@1,COG3842@2 NA|NA|NA P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system MAG.T1.121_00896 935839.JAGJ01000009_gene590 6.8e-32 144.8 Promicromonosporaceae Bacteria 2HY2W@201174,4F3KW@85017,COG1737@1,COG1737@2 NA|NA|NA K Helix-turn-helix domain, rpiR family MAG.T1.121_00897 1394178.AWOO02000018_gene6609 1e-72 280.8 Actinobacteria 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 Bacteria 2I8IJ@201174,COG0624@1,COG0624@2 NA|NA|NA E Acetylornithine deacetylase MAG.T1.121_00900 1178540.BA70_11425 1.6e-36 159.8 Bacillus ydhB GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K07090 ko00000 Bacteria 1TRFG@1239,1ZEEX@1386,4HGR6@91061,COG0730@1,COG0730@2 NA|NA|NA S membrane transporter protein MAG.T1.121_00901 479434.Sthe_1527 4.3e-36 157.1 Thermomicrobia yitW ko:K02612 ko00360,ko01120,map00360,map01120 R09838 RC02690 ko00000,ko00001 Bacteria 27YH9@189775,2G75C@200795,COG2151@1,COG2151@2 NA|NA|NA S Pfam:DUF59 MAG.T1.121_00902 1382356.JQMP01000003_gene2449 2.2e-10 72.4 Thermomicrobia GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.7.2.1 ko:K00368,ko:K18683 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 Bacteria 27YMB@189775,2GA6H@200795,COG4454@1,COG4454@2 NA|NA|NA P Copper binding proteins, plastocyanin/azurin family MAG.T1.121_00903 1382356.JQMP01000003_gene2449 2.2e-13 84.0 Thermomicrobia GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.7.2.1 ko:K00368,ko:K18683 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 Bacteria 27YMB@189775,2GA6H@200795,COG4454@1,COG4454@2 NA|NA|NA P Copper binding proteins, plastocyanin/azurin family MAG.T1.121_00904 357808.RoseRS_0780 4.7e-09 68.6 Chloroflexia Bacteria 2G84C@200795,375HH@32061,COG0438@1,COG0438@2,COG0500@1,COG2226@2 NA|NA|NA M PFAM glycosyl transferase group 1 MAG.T1.121_00906 479434.Sthe_0716 3.5e-77 295.4 Thermomicrobia hrcA GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 ko:K03705 ko00000,ko03000 Bacteria 27Y42@189775,2G6AQ@200795,COG1420@1,COG1420@2 NA|NA|NA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons MAG.T1.121_00907 324602.Caur_2075 9.7e-26 123.6 Chloroflexia grpE GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0017076,GO:0030234,GO:0030312,GO:0030554,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036094,GO:0040007,GO:0042594,GO:0044464,GO:0050790,GO:0050896,GO:0051082,GO:0051716,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0071496,GO:0071944,GO:0097159,GO:0098772,GO:1901265,GO:1901363 ko:K03687 ko00000,ko03029,ko03110 Bacteria 2G77I@200795,375MV@32061,COG0576@1,COG0576@2 NA|NA|NA O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ MAG.T1.121_00908 479434.Sthe_0714 4.1e-278 963.8 Thermomicrobia dnaK ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 Bacteria 27Y4Z@189775,2G5U5@200795,COG0443@1,COG0443@2 NA|NA|NA O MreB/Mbl protein MAG.T1.121_00910 1366046.HIMB11_00754 2.8e-39 168.3 unclassified Rhodobacteraceae dtd GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106026,GO:0106074,GO:0140098,GO:0140101,GO:1901360 ko:K07560 ko00000,ko01000,ko03016 Bacteria 1RGTV@1224,2U79I@28211,3ZHG8@58840,COG1490@1,COG1490@2 NA|NA|NA J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality MAG.T1.121_00911 479434.Sthe_0708 4.3e-46 191.0 Thermomicrobia ispF GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006629,GO:0006720,GO:0006721,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008270,GO:0008299,GO:0008610,GO:0008685,GO:0009058,GO:0009108,GO:0009987,GO:0016114,GO:0016829,GO:0016849,GO:0030145,GO:0040007,GO:0042180,GO:0042181,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051483,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.1.1.228,2.7.7.60,4.6.1.12 ko:K00554,ko:K00991,ko:K01770,ko:K12506 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R00597,R05633,R05637 RC00002,RC00003,RC00334,RC01440 ko00000,ko00001,ko00002,ko01000,ko03016 iNJ661.Rv3581c,iPC815.YPO3360 Bacteria 27YBC@189775,2G6RA@200795,COG0245@1,COG0245@2 NA|NA|NA H Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) MAG.T1.121_00912 479434.Sthe_0707 1.1e-36 160.2 Thermomicrobia ispD GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0050518,GO:0070567 2.7.7.60,4.6.1.12 ko:K00991,ko:K12506 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633,R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 Bacteria 27Y9J@189775,2G6UP@200795,COG1211@1,COG1211@2 NA|NA|NA I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) MAG.T1.121_00913 479434.Sthe_0705 8e-64 250.8 Thermomicrobia trpH 3.1.3.97,4.1.2.13 ko:K01624,ko:K07053 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R00188,R01068,R01070,R01829,R02568,R11188 RC00078,RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 Bacteria 27YVQ@189775,2G6H4@200795,COG0613@1,COG0613@2 NA|NA|NA S DNA polymerase alpha chain like domain MAG.T1.121_00914 479434.Sthe_0704 9.5e-34 150.2 Thermomicrobia ko:K06416 ko00000 Bacteria 27YG7@189775,2G77N@200795,COG2359@1,COG2359@2 NA|NA|NA S Stage V sporulation protein S (SpoVS) MAG.T1.121_00915 309801.trd_1879 7.9e-163 580.5 Thermomicrobia rny GO:0003674,GO:0005488,GO:0005515,GO:0042802 ko:K18682 ko03018,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 27Y2Z@189775,2G620@200795,COG1418@1,COG1418@2 NA|NA|NA S Domain of unknown function (DUF3552) MAG.T1.121_00916 525904.Tter_2237 8.8e-102 377.5 unclassified Bacteria norM ko:K03327 ko00000,ko02000 2.A.66.1 Bacteria 2NPBA@2323,COG0534@1,COG0534@2 NA|NA|NA V MATE efflux family protein MAG.T1.121_00917 479434.Sthe_1428 7e-11 73.6 Thermomicrobia Bacteria 27YMN@189775,2A4RD@1,2GBB6@200795,30TCS@2 NA|NA|NA S Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter MAG.T1.121_00918 309801.trd_1234 8.2e-75 287.3 Thermomicrobia atpB ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 Bacteria 27XY1@189775,2G6NF@200795,COG0356@1,COG0356@2 NA|NA|NA C it plays a direct role in the translocation of protons across the membrane MAG.T1.121_00919 309801.trd_1233 2e-17 94.7 Thermomicrobia atpE GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042802,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 ko:K02110,ko:K02124 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157,M00159 ko00000,ko00001,ko00002,ko00194 3.A.2.1,3.A.2.2,3.A.2.3 Bacteria 27YPV@189775,2G72D@200795,COG0636@1,COG0636@2 NA|NA|NA C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation MAG.T1.121_00920 479434.Sthe_1425 7.8e-19 100.5 Thermomicrobia atpF GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031225,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 e_coli_core.b3736,iAF1260.b3736,iB21_1397.B21_03564,iBWG_1329.BWG_3427,iE2348C_1286.E2348C_4046,iEC042_1314.EC042_4123,iEC55989_1330.EC55989_4211,iECABU_c1320.ECABU_c42210,iECBD_1354.ECBD_4296,iECB_1328.ECB_03620,iECDH10B_1368.ECDH10B_3923,iECDH1ME8569_1439.ECDH1ME8569_3624,iECD_1391.ECD_03620,iECED1_1282.ECED1_4426,iECH74115_1262.ECH74115_5172,iECIAI1_1343.ECIAI1_3920,iECIAI39_1322.ECIAI39_4340,iECO103_1326.ECO103_4422,iECO111_1330.ECO111_4570,iECO26_1355.ECO26_4842,iECOK1_1307.ECOK1_4185,iECP_1309.ECP_3935,iECS88_1305.ECS88_4158,iECSE_1348.ECSE_4026,iECSF_1327.ECSF_3584,iECSP_1301.ECSP_4786,iECUMN_1333.ECUMN_4266,iECW_1372.ECW_m4039,iECs_1301.ECs4678,iEKO11_1354.EKO11_4609,iETEC_1333.ETEC_4027,iEcDH1_1363.EcDH1_4231,iEcE24377_1341.EcE24377A_4252,iEcHS_1320.EcHS_A3952,iEcSMS35_1347.EcSMS35_4104,iEcolC_1368.EcolC_4258,iG2583_1286.G2583_4532,iJO1366.b3736,iJR904.b3736,iSDY_1059.SDY_4012,iSFV_1184.SFV_3762,iSF_1195.SF3816,iSFxv_1172.SFxv_4159,iSSON_1240.SSON_3883,iS_1188.S3952,iSbBS512_1146.SbBS512_E4185,iUMN146_1321.UM146_18870,iUMNK88_1353.UMNK88_4548,iUTI89_1310.UTI89_C4291,iWFL_1372.ECW_m4039,iY75_1357.Y75_RS18390,iZ_1308.Z5234,ic_1306.c4664 Bacteria 27YGB@189775,2G76T@200795,COG0711@1,COG0711@2 NA|NA|NA C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) MAG.T1.121_00921 479434.Sthe_1424 1.6e-35 156.0 Thermomicrobia atpH GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 ko:K02109,ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 Bacteria 27YHC@189775,2G78B@200795,COG0712@1,COG0712@2 NA|NA|NA C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation MAG.T1.121_00922 479434.Sthe_1423 2.9e-210 738.0 Thermomicrobia atpA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 iIT341.HP1134,iSB619.SA_RS10975,iSbBS512_1146.SbBS512_E4187 Bacteria 27XTP@189775,2G5YQ@200795,COG0056@1,COG0056@2 NA|NA|NA F Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit MAG.T1.121_00923 309801.trd_1229 3.9e-87 328.2 Thermomicrobia atpG GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 iLJ478.TM1611,iSSON_1240.SSON_3886,iYL1228.KPN_04138 Bacteria 27XXK@189775,2G69I@200795,COG0224@1,COG0224@2 NA|NA|NA C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex MAG.T1.121_00924 252305.OB2597_09164 8.8e-55 221.1 Bacteria Bacteria 2F0YT@1,33U0F@2 NA|NA|NA MAG.T1.121_00925 479434.Sthe_2780 3.3e-88 332.0 Thermomicrobia Bacteria 27XJR@189775,2G7MH@200795,COG0823@1,COG0823@2,COG1506@1,COG1506@2 NA|NA|NA EU Peptidase S9, prolyl oligopeptidase active site domain protein MAG.T1.121_00926 1382356.JQMP01000003_gene2423 4.9e-43 182.2 Thermomicrobia dapE2 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 Bacteria 27XZ7@189775,2G8FI@200795,COG0624@1,COG0624@2 NA|NA|NA E TIGRFAM acetylornithine deacetylase or succinyl- diaminopimelate desuccinylase MAG.T1.121_00927 479434.Sthe_0925 1.2e-31 142.5 Thermomicrobia Bacteria 27YIR@189775,2GBAM@200795,COG3870@1,COG3870@2 NA|NA|NA S Cyclic-di-AMP receptor MAG.T1.121_00928 479434.Sthe_0917 2.3e-10 71.2 Bacteria Bacteria COG1522@1,COG1522@2 NA|NA|NA K sequence-specific DNA binding MAG.T1.121_00930 479434.Sthe_0916 4e-65 255.0 Thermomicrobia suhB GO:0003674,GO:0003824,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0042578,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616 3.1.3.25,3.1.3.7 ko:K01082,ko:K01092 ko00521,ko00562,ko00920,ko01100,ko01120,ko01130,ko04070,map00521,map00562,map00920,map01100,map01120,map01130,map04070 M00131 R00188,R00508,R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000,ko03016 Bacteria 27Y5G@189775,2G6JD@200795,COG0483@1,COG0483@2 NA|NA|NA G Inositol monophosphatase family MAG.T1.121_00931 479434.Sthe_0915 2.2e-111 409.1 Thermomicrobia tsaD GO:0000287,GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140030,GO:0140032,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 ko:K01409,ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 R10648 RC00070,RC00416 ko00000,ko00001,ko00002,ko01000,ko02044,ko03016 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 Bacteria 27XRB@189775,2G5V0@200795,COG0533@1,COG0533@2 NA|NA|NA J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction MAG.T1.121_00932 479434.Sthe_0914 3.8e-56 224.9 Thermomicrobia rimI 2.3.1.128 ko:K03789,ko:K14742 ko00000,ko01000,ko03009,ko03016 Bacteria 27Y7H@189775,2G6TF@200795,COG0454@1,COG0456@2 NA|NA|NA K FR47-like protein MAG.T1.121_00933 479434.Sthe_0913 9.2e-31 140.6 Thermomicrobia yeaZ GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 ko:K01409,ko:K14742 R10648 RC00070,RC00416 ko00000,ko01000,ko03016 Bacteria 27YCB@189775,2G6VT@200795,COG1214@1,COG1214@2 NA|NA|NA O Glycoprotease family MAG.T1.121_00934 525904.Tter_2292 5.1e-96 357.8 Bacteria ugpA ko:K02025,ko:K05814,ko:K10118,ko:K10237,ko:K10241,ko:K15771,ko:K17235,ko:K17316 ko02010,map02010 M00196,M00198,M00204,M00206,M00207,M00491,M00602,M00605 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.17,3.A.1.1.2,3.A.1.1.23,3.A.1.1.24,3.A.1.1.28,3.A.1.1.3,3.A.1.1.30,3.A.1.1.34 Bacteria COG1175@1,COG1175@2 NA|NA|NA P transmembrane transport MAG.T1.121_00935 525904.Tter_2293 4.4e-94 351.3 unclassified Bacteria ugpE ko:K02026,ko:K05815 ko02010,map02010 M00198,M00207 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.3 Bacteria 2NPII@2323,COG0395@1,COG0395@2 NA|NA|NA G PFAM binding-protein-dependent transport systems inner membrane component MAG.T1.121_00936 1382356.JQMP01000001_gene898 4.2e-141 508.1 Thermomicrobia ko:K02027,ko:K05813 ko02010,map02010 M00198,M00207 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.3 Bacteria 27YX1@189775,2G6V5@200795,COG1653@1,COG1653@2 NA|NA|NA G Bacterial extracellular solute-binding protein MAG.T1.121_00937 479434.Sthe_0912 4.3e-24 117.9 Thermomicrobia yjeE 2.7.1.221 ko:K06925,ko:K07102 ko00520,ko01100,map00520,map01100 R08968,R11024 RC00002,RC00078 ko00000,ko00001,ko01000,ko03016 Bacteria 27YBZ@189775,2G6YV@200795,COG0802@1,COG0802@2 NA|NA|NA S Threonylcarbamoyl adenosine biosynthesis protein TsaE MAG.T1.121_00938 266117.Rxyl_1173 2e-93 349.4 Rubrobacteria fbpC 3.6.3.30 ko:K02010 ko02010,map02010 M00190 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10 Bacteria 2GJCM@201174,4CRCY@84995,COG3842@1,COG3842@2 NA|NA|NA P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system MAG.T1.121_00939 479434.Sthe_3207 1.7e-128 466.5 Thermomicrobia sfuB ko:K02011 ko02010,map02010 M00190 ko00000,ko00001,ko00002,ko02000 3.A.1.10 Bacteria 27YXM@189775,2G5Q0@200795,COG1178@1,COG1178@2 NA|NA|NA U binding-protein-dependent transport systems inner membrane component MAG.T1.121_00940 649638.Trad_1534 1.3e-90 339.7 Deinococcus-Thermus ko:K02012 ko02010,map02010 M00190 ko00000,ko00001,ko00002,ko02000 3.A.1.10 Bacteria 1WITN@1297,COG1840@1,COG1840@2 NA|NA|NA P ABC-type Fe3 transport system, periplasmic component MAG.T1.121_00941 1122939.ATUD01000011_gene2206 1.4e-53 216.5 Rubrobacteria 2.3.1.247 ko:K18013 ko00310,map00310 R10564 RC02728,RC03199 ko00000,ko00001,ko01000 Bacteria 2GMMZ@201174,4CTHV@84995,COG3246@1,COG3246@2 NA|NA|NA S beta-keto acid cleavage enzyme MAG.T1.121_00942 1172181.KB911700_gene7628 2.4e-134 485.3 Actinobacteria ttuC 1.1.1.83,1.1.1.93,4.1.1.73 ko:K07246 ko00630,ko00650,map00630,map00650 R00215,R01751,R02545,R06180 RC00084,RC00105,RC00594 ko00000,ko00001,ko01000 Bacteria 2GK44@201174,COG0473@1,COG0473@2 NA|NA|NA CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate MAG.T1.121_00943 1146883.BLASA_1320 3.6e-32 144.8 Frankiales Bacteria 2GRBQ@201174,4EWIX@85013,COG2258@1,COG2258@2 NA|NA|NA S MOSC domain MAG.T1.121_00944 1128421.JAGA01000001_gene2134 2.8e-203 715.7 unclassified Bacteria ppc GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 iJN678.ppc Bacteria 2NQRN@2323,COG2352@1,COG2352@2 NA|NA|NA C Phosphoenolpyruvate carboxylase MAG.T1.121_00945 926550.CLDAP_10900 3.6e-28 133.7 Chloroflexi enhA_2 ko:K03791,ko:K08307,ko:K12204 ko00000,ko01000,ko01011,ko02044 3.A.7.10.1,3.A.7.9.1 GH19 Bacteria 2G6ZY@200795,COG1376@1,COG1376@2,COG1388@1,COG1388@2 NA|NA|NA M PFAM ErfK YbiS YcfS YnhG family protein MAG.T1.121_00946 1173025.GEI7407_3015 3.4e-26 125.9 Oscillatoriales enhA_2 Bacteria 1G4ZS@1117,1HAVT@1150,COG1376@1,COG1376@2 NA|NA|NA S ErfK YbiS YcfS YnhG MAG.T1.121_00947 479434.Sthe_0170 3.6e-107 395.2 Thermomicrobia puuB Bacteria 27Z3M@189775,2G8SD@200795,COG0665@1,COG0665@2 NA|NA|NA E FAD binding domain MAG.T1.121_00948 196162.Noca_4966 2e-143 516.5 Actinobacteria ko:K06994,ko:K07003 ko00000 Bacteria 2GJ5A@201174,COG2409@1,COG2409@2 NA|NA|NA F Drug exporters of the RND superfamily MAG.T1.121_00949 926569.ANT_12490 4.6e-56 224.6 Chloroflexi yhcZ ko:K02479 ko00000,ko02022 Bacteria 2G6T1@200795,COG2197@1,COG2197@2 NA|NA|NA K Two component transcriptional regulator, LuxR family MAG.T1.121_00950 765420.OSCT_1712 7e-34 151.8 Chloroflexia 2.7.13.3 ko:K11617 ko02020,map02020 M00481,M00754 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 2G8GW@200795,3776B@32061,COG2203@1,COG2203@2,COG4585@1,COG4585@2 NA|NA|NA T histidine kinase, dimerisation and phosphoacceptor region MAG.T1.121_00951 479434.Sthe_0209 9.6e-62 243.0 Chloroflexi ppa 3.6.1.1 ko:K01507 ko00190,map00190 ko00000,ko00001,ko01000 Bacteria 2G6T4@200795,COG0221@1,COG0221@2 NA|NA|NA C Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions MAG.T1.121_00952 525904.Tter_0616 9.1e-30 137.5 unclassified Bacteria Bacteria 2NRU9@2323,3325R@2,arCOG09854@1 NA|NA|NA MAG.T1.121_00953 479434.Sthe_2169 8.4e-54 218.8 Thermomicrobia yebE GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K06596,ko:K11962 ko02010,ko02020,ko02025,map02010,map02020,map02025 M00323,M00507 ko00000,ko00001,ko00002,ko01001,ko02000,ko02022,ko02035 3.A.1.4.4,3.A.1.4.5 Bacteria 27YIA@189775,2GBAG@200795,COG2979@1,COG2979@2 NA|NA|NA S Protein of unknown function (DUF533) MAG.T1.121_00954 1242864.D187_003684 2.9e-20 105.1 Bacteria Bacteria COG1846@1,COG1846@2 NA|NA|NA K DNA-binding transcription factor activity MAG.T1.121_00956 1489678.RDMS_03285 1.1e-22 113.6 Deinococcus-Thermus trx-2 ko:K02199,ko:K03671 ko04621,ko05418,map04621,map05418 ko00000,ko00001,ko03110 Bacteria 1WJ2P@1297,COG0526@1,COG0526@2 NA|NA|NA CO periplasmic protein thiol disulfide oxidoreductases, DsbE subfamily MAG.T1.121_00957 479434.Sthe_0386 6.6e-104 384.0 Thermomicrobia ilvE 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 27Y0I@189775,2G6AX@200795,COG0115@1,COG0115@2 NA|NA|NA E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family MAG.T1.121_00958 1382306.JNIM01000001_gene160 3e-29 135.2 Chloroflexi Bacteria 2G7I0@200795,COG1695@1,COG1695@2 NA|NA|NA K PFAM transcriptional regulator PadR family protein MAG.T1.121_00959 309801.trd_0888 1.4e-25 122.9 Thermomicrobia Bacteria 27Z77@189775,2G8Z8@200795,COG0517@1,COG0517@2 NA|NA|NA S Domain in cystathionine beta-synthase and other proteins. MAG.T1.121_00960 1255043.TVNIR_0682 3.5e-13 82.0 Gammaproteobacteria Bacteria 1R18C@1224,1T4WH@1236,COG0640@1,COG0640@2 NA|NA|NA K Transcriptional regulator MAG.T1.121_00961 479434.Sthe_0688 1.1e-87 330.5 Thermomicrobia pfp 2.7.1.11,2.7.1.90 ko:K00850,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 Bacteria 27Y44@189775,2G81H@200795,COG0205@1,COG0205@2 NA|NA|NA H Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions MAG.T1.121_00962 479434.Sthe_0687 3.3e-158 565.5 Thermomicrobia Bacteria 27ZB1@189775,2GAC1@200795,COG0699@1,COG0699@2 NA|NA|NA S Dynamin family MAG.T1.121_00964 1167006.UWK_00678 1e-58 233.8 Desulfobacterales dapF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 iIT341.HP0566,iLJ478.TM1522 Bacteria 1MWDH@1224,2MJMR@213118,2WMP4@28221,42MRX@68525,COG0253@1,COG0253@2 NA|NA|NA E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan MAG.T1.121_00967 1189620.AJXL01000097_gene2050 5.7e-47 194.9 Flavobacterium ko:K22044 ko00000,ko02000 1.A.23.3 Bacteria 1ICX5@117743,2NVTM@237,4NH7C@976,COG0668@1,COG0668@2 NA|NA|NA M Mechanosensitive ion channel MAG.T1.121_00968 309801.trd_1847 8.4e-268 929.9 Thermomicrobia cutL 1.2.5.3 ko:K03520 R11168 RC02800 ko00000,ko01000 Bacteria 27XQT@189775,2G82V@200795,COG1529@1,COG1529@2 NA|NA|NA C Dehydrogenase MAG.T1.121_00970 1535287.JP74_19355 3.1e-42 179.1 Hyphomicrobiaceae 2.7.1.15 ko:K00852 ko00030,map00030 R01051,R02750 RC00002,RC00017 ko00000,ko00001,ko01000 Bacteria 1Q17V@1224,2U6Q0@28211,3N7H2@45401,COG0524@1,COG0524@2 NA|NA|NA G pfkB family carbohydrate kinase MAG.T1.121_00971 585531.HMPREF0063_12669 4.9e-93 347.8 Propionibacteriales psuG GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0019200,GO:0044237,GO:0044238,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046835,GO:0071704 4.2.1.70 ko:K16329 ko00240,map00240 R01055 RC00432,RC00433 ko00000,ko00001,ko01000 Bacteria 2GK19@201174,4DNR3@85009,COG2313@1,COG2313@2 NA|NA|NA Q Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway MAG.T1.121_00972 1033743.CAES01000040_gene1365 9.8e-53 214.2 Paenibacillaceae ko:K18106 ko00040,ko01100,map00040,map01100 M00630 R07676,R10565 RC00108 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQJX@1239,26WFD@186822,4HAJ8@91061,COG0673@1,COG0673@2 NA|NA|NA S Oxidoreductase family, NAD-binding Rossmann fold MAG.T1.121_00973 1382356.JQMP01000003_gene1417 1.7e-67 263.1 Thermomicrobia Bacteria 27Y7R@189775,2G8CA@200795,COG2141@1,COG2141@2 NA|NA|NA C Luciferase-like monooxygenase MAG.T1.121_00975 479434.Sthe_1346 2.6e-25 122.1 Thermomicrobia Bacteria 27YC8@189775,298YA@1,2G6UQ@200795,2ZW25@2 NA|NA|NA S Protein of unknown function (DUF3090) MAG.T1.121_00976 479434.Sthe_2220 1.2e-99 370.2 Thermomicrobia rodA ko:K05837 ko00000,ko03036 Bacteria 27XZP@189775,2G6GW@200795,COG0772@1,COG0772@2 NA|NA|NA D Cell cycle protein MAG.T1.121_00977 479434.Sthe_1932 1.7e-55 223.0 Thermomicrobia rsmI GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.198 ko:K07056 ko00000,ko01000,ko03009 Bacteria 27Y2H@189775,2G6E3@200795,COG0313@1,COG0313@2 NA|NA|NA H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA MAG.T1.121_00978 479434.Sthe_1931 9e-118 431.0 Thermomicrobia dnaX GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0042575,GO:0042802,GO:0043170,GO:0043846,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050790,GO:0061695,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7,6.1.1.17 ko:K01885,ko:K02341,ko:K02343 ko00230,ko00240,ko00860,ko00970,ko01100,ko01110,ko01120,ko03030,ko03430,ko03440,map00230,map00240,map00860,map00970,map01100,map01110,map01120,map03030,map03430,map03440 M00121,M00260,M00359,M00360 R00375,R00376,R00377,R00378,R05578 RC00055,RC00523,RC02795 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016,ko03032,ko03400 Bacteria 27XHA@189775,2G5PK@200795,COG2812@1,COG2812@2,COG3266@1,COG3266@2 NA|NA|NA L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity MAG.T1.121_00980 309801.trd_1757 3.2e-20 104.4 Thermomicrobia gatC 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 iAF987.Gmet_0076 Bacteria 27YK5@189775,2G763@200795,COG0721@1,COG0721@2 NA|NA|NA J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) MAG.T1.121_00981 479434.Sthe_1927 1.3e-186 659.4 Thermomicrobia gatA GO:0008150,GO:0040007 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 Bacteria 27Y0A@189775,2G5T0@200795,COG0154@1,COG0154@2 NA|NA|NA J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) MAG.T1.121_00984 1121381.JNIV01000034_gene1578 1e-110 407.1 Deinococcus-Thermus mgtE 3.6.1.1 ko:K04767,ko:K06213,ko:K15986 ko00190,map00190 ko00000,ko00001,ko01000,ko02000 1.A.26.1 Bacteria 1WI4V@1297,COG2239@1,COG2239@2 NA|NA|NA P Acts as a magnesium transporter MAG.T1.121_00985 867845.KI911784_gene380 7.6e-13 80.9 Chloroflexia Bacteria 2G95K@200795,375UR@32061,COG3544@1,COG3544@2 NA|NA|NA S Domain of unknown function (DUF4142) MAG.T1.121_00986 357808.RoseRS_3156 0.0 1337.8 Chloroflexi Bacteria 2G678@200795,COG4447@1,COG4447@2 NA|NA|NA S PFAM glycosyl hydrolase BNR repeat-containing protein MAG.T1.121_00987 479434.Sthe_1595 5.6e-36 157.5 Thermomicrobia rplI GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02939 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 27YFC@189775,2G6V2@200795,COG0359@1,COG0359@2 NA|NA|NA J Ribosomal protein L9, C-terminal domain MAG.T1.121_00988 479434.Sthe_1596 1.9e-165 589.0 Thermomicrobia dnaB GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 ko00000,ko00001,ko01000,ko03032 Bacteria 27XKA@189775,2G64D@200795,COG0305@1,COG0305@2 NA|NA|NA L Participates in initiation and elongation during chromosome replication MAG.T1.121_00989 479434.Sthe_1597 4.7e-33 148.3 Thermomicrobia ko:K02086 ko00000 Bacteria 27YDD@189775,2G6W5@200795,COG3935@1,COG3935@2 NA|NA|NA L Replication initiation and membrane attachment MAG.T1.121_00990 309801.trd_0690 1.4e-52 213.0 Thermomicrobia ko:K02315 ko00000,ko03032 Bacteria 27YCI@189775,2G65F@200795,COG1484@1,COG1484@2 NA|NA|NA L Bacterial dnaA protein MAG.T1.121_00991 479434.Sthe_1601 3.1e-90 338.6 Thermomicrobia dacA GO:0003674,GO:0003824,GO:0004016,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0009975,GO:0016020,GO:0016021,GO:0016829,GO:0016849,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 2.7.7.85 ko:K18672 ko00000,ko01000 Bacteria 27XJ7@189775,2G6J7@200795,COG1624@1,COG1624@2 NA|NA|NA S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria MAG.T1.121_00992 1382356.JQMP01000004_gene73 8.4e-46 191.4 Thermomicrobia ybbR GO:0008150,GO:0031279,GO:0031281,GO:0043085,GO:0044093,GO:0045761,GO:0045762,GO:0050790,GO:0051339,GO:0051349,GO:0065007,GO:0065009 Bacteria 27YNP@189775,2G75D@200795,COG4856@1,COG4856@2 NA|NA|NA S YbbR-like protein MAG.T1.121_00993 479434.Sthe_1603 1.4e-68 266.2 Thermomicrobia gnfR ko:K22010 M00839 ko00000,ko00002,ko02022 Bacteria 27XQ5@189775,2G6CD@200795,COG3707@1,COG3707@2 NA|NA|NA T ANTAR MAG.T1.121_00995 479434.Sthe_1604 6.9e-36 156.8 Thermomicrobia rplL ko:K02935 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 27YF7@189775,2G700@200795,COG0222@1,COG0222@2 NA|NA|NA J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation MAG.T1.121_00996 479434.Sthe_1605 7.4e-44 183.7 Thermomicrobia rplJ GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0017148,GO:0019222,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 ko:K02864,ko:K02935 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 27YC4@189775,2G6XJ@200795,COG0244@1,COG0244@2 NA|NA|NA J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors MAG.T1.121_00997 1382356.JQMP01000004_gene77 7.6e-84 317.0 Thermomicrobia rplA GO:0000027,GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006417,GO:0006446,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0017148,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045947,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 ko:K02863 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 27XYK@189775,2G6AW@200795,COG0081@1,COG0081@2 NA|NA|NA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release MAG.T1.121_00998 479434.Sthe_1607 3.8e-59 234.2 Thermomicrobia rplK GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010467,GO:0015934,GO:0015968,GO:0016043,GO:0019538,GO:0019843,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0032984,GO:0032991,GO:0033554,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0042594,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0051716,GO:0065003,GO:0070925,GO:0071496,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02867 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 27Y72@189775,2G6FF@200795,COG0080@1,COG0080@2 NA|NA|NA J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors MAG.T1.121_00999 479434.Sthe_1608 2.1e-74 285.4 Thermomicrobia nusG GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 ko:K02601 ko00000,ko03009,ko03021 Bacteria 27XZ9@189775,2G6A3@200795,COG0250@1,COG0250@2 NA|NA|NA K Participates in transcription elongation, termination and antitermination MAG.T1.121_01000 1382356.JQMP01000004_gene80 2.6e-08 65.1 Thermomicrobia secE GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K03073 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 Bacteria 27YQ7@189775,2GBBW@200795,COG0690@1,COG0690@2 NA|NA|NA U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation MAG.T1.121_01002 479434.Sthe_1610 1.2e-19 101.7 Thermomicrobia rpmG ko:K02913 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 27ZAY@189775,2G7GT@200795,COG0267@1,COG0267@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL33 family MAG.T1.121_01003 479434.Sthe_1611 1.8e-194 685.3 Thermomicrobia tuf ko:K02358 ko00000,ko03012,ko03029,ko04147 Bacteria 27XXD@189775,2G5KI@200795,COG0050@1,COG0050@2 NA|NA|NA J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis MAG.T1.121_01004 479434.Sthe_1033 8.4e-301 1039.3 Thermomicrobia fusA GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0030312,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02355 ko00000,ko03012,ko03029 Bacteria 27XU6@189775,2G63B@200795,COG0480@1,COG0480@2 NA|NA|NA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome MAG.T1.121_01005 479434.Sthe_1032 5.3e-54 217.2 Thermomicrobia rpsG GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0016020,GO:0016043,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 ko:K02992 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 27Y66@189775,2G6GR@200795,COG0049@1,COG0049@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA MAG.T1.121_01006 479434.Sthe_1031 9.9e-60 236.1 Thermomicrobia rpsL GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02950 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 27YD6@189775,2G6EX@200795,COG0048@1,COG0048@2 NA|NA|NA J Ribosomal protein S12/S23 MAG.T1.121_01007 994573.T472_0201110 4.5e-31 142.9 Clostridiaceae 3.2.1.96,3.4.17.14,3.5.1.104,3.5.1.28 ko:K01227,ko:K07260,ko:K13714,ko:K13731,ko:K22278 ko00511,ko00550,ko01100,ko01502,ko02020,ko05100,map00511,map00550,map01100,map01502,map02020,map05100 M00651 ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504 GH73 Bacteria 1V6DN@1239,24MJ1@186801,36UIM@31979,COG0726@1,COG0726@2,COG3103@1,COG3103@2 NA|NA|NA G Polysaccharide deacetylase MAG.T1.121_01008 479434.Sthe_1030 1.9e-212 745.7 Thermomicrobia rpoC GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 Bacteria 27Y0B@189775,2G632@200795,COG0086@1,COG0086@2 NA|NA|NA K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates MAG.T1.121_01009 1280949.HAD_10860 3.1e-15 87.8 Alphaproteobacteria Bacteria 1MWKN@1224,2UPP1@28211,COG1629@1,COG4771@2 NA|NA|NA P TonB-dependent receptor MAG.T1.121_01010 309801.trd_1226 4e-119 434.9 Thermomicrobia murA 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 R00660 RC00350 ko00000,ko00001,ko01000,ko01011 Bacteria 27XF5@189775,2G666@200795,COG0766@1,COG0766@2 NA|NA|NA M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine MAG.T1.121_01011 644968.DFW101_2155 4.7e-19 100.9 Desulfovibrionales Bacteria 1R5EN@1224,2MHC1@213115,2X7ZW@28221,43CS7@68525,COG5002@1,COG5002@2 NA|NA|NA T histidine kinase HAMP region domain protein MAG.T1.121_01012 479434.Sthe_2625 1.3e-65 256.5 Chloroflexi dpm1 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 R01009 RC00005 ko00000,ko00001,ko01000,ko01003 GT2 Bacteria 2G69V@200795,COG1216@1,COG1216@2 NA|NA|NA S PFAM Glycosyl transferase family 2 MAG.T1.121_01013 479434.Sthe_3332 1.1e-130 473.4 Thermomicrobia sufS Bacteria 27Z06@189775,2G7ZH@200795,COG0520@1,COG0520@2 NA|NA|NA E Cys/Met metabolism PLP-dependent enzyme MAG.T1.121_01014 479434.Sthe_1349 1.6e-94 352.8 Thermomicrobia rnz GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267 3.1.26.11 ko:K00784 ko03013,map03013 ko00000,ko00001,ko01000,ko03016 Bacteria 27XSQ@189775,2G6YW@200795,COG1234@1,COG1234@2 NA|NA|NA J Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA MAG.T1.121_01015 309801.trd_0544 7.1e-45 188.3 Thermomicrobia Bacteria 27XRZ@189775,2G6PZ@200795,COG1316@1,COG1316@2 NA|NA|NA K cell envelope-related transcriptional attenuator MAG.T1.121_01016 266117.Rxyl_2383 1.7e-182 646.0 Rubrobacteria ko:K06978 ko00000 Bacteria 2GK8B@201174,4CQZX@84995,COG2936@1,COG2936@2 NA|NA|NA S Peptidase S15 MAG.T1.121_01017 1382356.JQMP01000004_gene571 5.7e-84 317.8 Thermomicrobia mcl1 4.1.3.24,4.1.3.25,4.1.3.34,5.4.99.63 ko:K01644,ko:K08691,ko:K14447,ko:K18292 ko00630,ko00660,ko00680,ko00720,ko01100,ko01120,ko01200,ko02020,map00630,map00660,map00680,map00720,map01100,map01120,map01200,map02020 M00346,M00373,M00376 R00237,R00362,R00473,R00934,R09292 RC00067,RC00307,RC00308,RC00311,RC00407,RC00502,RC01118,RC01205,RC02835 ko00000,ko00001,ko00002,ko01000 Bacteria 27XJ2@189775,2G6EA@200795,COG2301@1,COG2301@2 NA|NA|NA G Belongs to the HpcH HpaI aldolase family MAG.T1.121_01018 1128421.JAGA01000003_gene2740 2.7e-26 125.2 unclassified Bacteria rpmE ko:K02909 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2NPUV@2323,COG0254@1,COG0254@2 NA|NA|NA J Binds the 23S rRNA MAG.T1.121_01019 246194.CHY_0368 4.6e-25 120.6 Thermoanaerobacterales rpmA GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904 ko:K02899 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V6HW@1239,24N3D@186801,42GQM@68295,COG0211@1,COG0211@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL27 family MAG.T1.121_01020 1382304.JNIL01000001_gene203 2.6e-29 134.8 Alicyclobacillaceae rplU GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02888 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V9YH@1239,278J6@186823,4HIGK@91061,COG0261@1,COG0261@2 NA|NA|NA J This protein binds to 23S rRNA in the presence of protein L20 MAG.T1.121_01021 1382356.JQMP01000004_gene664 5.3e-59 234.6 Thermomicrobia Bacteria 27XMW@189775,2G6A5@200795,COG0745@1,COG0745@2 NA|NA|NA K Two component transcriptional regulator, winged helix family MAG.T1.121_01022 243164.DET0136 1.1e-70 274.2 Dehalococcoidia phoR 2.7.13.3 ko:K02484,ko:K07636,ko:K07768,ko:K11527,ko:K17292,ko:K19616 ko02020,map02020 M00434,M00443,M00771 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko04147,ko04812 Bacteria 2G67W@200795,34D12@301297,COG4191@1,COG4191@2,COG5002@1,COG5002@2 NA|NA|NA T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain MAG.T1.121_01023 309801.trd_1280 4.4e-92 344.7 Thermomicrobia ko:K02034,ko:K15582 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 27Z1W@189775,2G6HB@200795,COG1173@1,COG1173@2 NA|NA|NA EP Binding-protein-dependent transport system inner membrane component MAG.T1.121_01024 479434.Sthe_2204 1.3e-110 406.4 Thermomicrobia ko:K02033 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 27YSV@189775,2GBCN@200795,COG0601@1,COG0601@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component MAG.T1.121_01025 309801.trd_1281 2.5e-141 509.2 Thermomicrobia ko:K02035 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 27YT9@189775,2GA2M@200795,COG0747@1,COG0747@2 NA|NA|NA E Bacterial extracellular solute-binding proteins, family 5 Middle MAG.T1.121_01027 479434.Sthe_2665 1.3e-43 184.9 Chloroflexi Bacteria 2GA77@200795,COG0642@1,COG2203@1,COG2203@2,COG2205@2 NA|NA|NA T His Kinase A (phosphoacceptor) domain MAG.T1.121_01028 479434.Sthe_3286 9.8e-84 317.4 Thermomicrobia MA20_07365 ko:K05825 ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210 R01939 RC00006 ko00000,ko00001,ko01000 Bacteria 27XHW@189775,2G61E@200795,COG1167@1,COG1167@2 NA|NA|NA EK Alanine-glyoxylate amino-transferase MAG.T1.121_01029 479434.Sthe_2564 1.3e-110 406.4 Thermomicrobia yumC GO:0008150,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0042221,GO:0050896,GO:0051716,GO:0070887,GO:0071241,GO:0071248,GO:0071281 1.18.1.2,1.19.1.1 ko:K21567 ko00000,ko01000 iYO844.BSU32110 Bacteria 27XWC@189775,2GB7X@200795,COG0492@1,COG0492@2 NA|NA|NA C Ferredoxin--NADP reductase MAG.T1.121_01030 383372.Rcas_2856 1.6e-30 140.6 Chloroflexia Bacteria 2G85V@200795,3776X@32061,COG0738@1,COG0738@2 NA|NA|NA G PFAM major facilitator superfamily MFS_1 MAG.T1.121_01031 479434.Sthe_3196 6.4e-105 387.5 Thermomicrobia trpS GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 27XUX@189775,2G5SH@200795,COG0180@1,COG0180@2 NA|NA|NA J tRNA synthetases class I (W and Y) MAG.T1.121_01032 309801.trd_0463 6.3e-128 464.5 Thermomicrobia MA20_01895 Bacteria 27Y46@189775,2G5SE@200795,COG1233@1,COG1233@2 NA|NA|NA Q Flavin containing amine oxidoreductase MAG.T1.121_01033 937777.Deipe_2651 6.7e-55 221.1 Bacteria dppA ko:K16203 ko00000,ko01000,ko01002 3.A.1.5.2 Bacteria COG2362@1,COG2362@2 NA|NA|NA E D-aminopeptidase MAG.T1.121_01034 40571.JOEA01000027_gene5889 2.4e-19 101.7 Pseudonocardiales Bacteria 2II0D@201174,4E47X@85010,COG4430@1,COG4430@2 NA|NA|NA S Bacteriocin-protection, YdeI or OmpD-Associated MAG.T1.121_01035 479434.Sthe_2369 9.5e-25 120.9 Thermomicrobia Bacteria 27YEP@189775,2A4QG@1,2GB9Y@200795,30TBR@2 NA|NA|NA MAG.T1.121_01036 479434.Sthe_2381 1.3e-239 835.9 Thermomicrobia acs 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 27XH3@189775,2G830@200795,COG0365@1,COG0365@2 NA|NA|NA I Acetyl-coenzyme A synthetase N-terminus MAG.T1.121_01037 1382306.JNIM01000001_gene1515 5.5e-121 441.0 Chloroflexi Bacteria 2G71U@200795,COG0010@1,COG0010@2 NA|NA|NA E Belongs to the arginase family MAG.T1.121_01038 309801.trd_1239 8.8e-37 160.6 Thermomicrobia Bacteria 27YFA@189775,2G996@200795,COG1434@1,COG1434@2 NA|NA|NA S DUF218 domain MAG.T1.121_01039 298653.Franean1_0373 8.3e-59 234.2 Frankiales lpqC ko:K03932 ko00000 CE1 Bacteria 2GNV6@201174,4EU0N@85013,COG3509@1,COG3509@2 NA|NA|NA Q Esterase PHB depolymerase MAG.T1.121_01041 1123023.JIAI01000007_gene1829 6.2e-45 187.2 Bacteria pdxH ko:K07005 ko00000 Bacteria COG3467@1,COG3467@2 NA|NA|NA T pyridoxamine 5'-phosphate MAG.T1.121_01044 546414.Deide_01241 2e-35 155.2 Bacteria Bacteria COG0607@1,COG0607@2 NA|NA|NA P Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS MAG.T1.121_01045 926554.KI912673_gene2802 2.4e-54 219.5 Bacteria Bacteria COG2909@1,COG2909@2 NA|NA|NA K trisaccharide binding MAG.T1.121_01046 546268.NEISUBOT_05482 6.9e-14 83.6 Proteobacteria Bacteria 1P3MU@1224,2DXS1@1,32V40@2 NA|NA|NA MAG.T1.121_01047 479434.Sthe_1165 1.3e-09 70.9 Thermomicrobia Bacteria 27YJP@189775,2E7PW@1,2G7GZ@200795,3325F@2 NA|NA|NA MAG.T1.121_01048 1463864.JOGO01000057_gene3893 3.1e-23 114.8 Actinobacteria Bacteria 2IKXW@201174,COG3824@1,COG3824@2 NA|NA|NA S protein conserved in bacteria MAG.T1.121_01049 479434.Sthe_1163 5.3e-98 365.2 Thermomicrobia pbpA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 ko:K05364 ko00550,map00550 R04519 RC00005,RC00049 ko00000,ko00001,ko01011 Bacteria 27XRU@189775,2G7V1@200795,COG0768@1,COG0768@2 NA|NA|NA M Penicillin binding protein transpeptidase domain MAG.T1.121_01050 479434.Sthe_1162 5.1e-86 325.1 Thermomicrobia rodA GO:0002682,GO:0002684,GO:0008150,GO:0009605,GO:0009607,GO:0009987,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051301,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0075136 ko:K03588,ko:K05364,ko:K05837 ko00550,ko04112,map00550,map04112 R04519 RC00005,RC00049 ko00000,ko00001,ko01011,ko02000,ko03036 2.A.103.1 Bacteria 27Y4C@189775,2G6NR@200795,COG0772@1,COG0772@2 NA|NA|NA D Cell cycle protein MAG.T1.121_01051 204669.Acid345_2626 7.2e-81 307.4 Acidobacteriia mtnP GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004731,GO:0006082,GO:0006139,GO:0006144,GO:0006168,GO:0006520,GO:0006555,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009112,GO:0009113,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0017061,GO:0017144,GO:0018130,GO:0019438,GO:0019509,GO:0019752,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0055086,GO:0071265,GO:0071267,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.28 ko:K00772 ko00270,ko01100,map00270,map01100 M00034 R01402 RC00063,RC02819 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2684 Bacteria 2JI5Q@204432,3Y2MA@57723,COG0005@1,COG0005@2 NA|NA|NA F Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates MAG.T1.121_01052 218140.BPSY_0961 9.1e-27 125.9 Bifidobacteriales rpsO GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006378,GO:0006396,GO:0006397,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016071,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031123,GO:0031124,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043631,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02956 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IQA0@201174,4D10E@85004,COG0184@1,COG0184@2 NA|NA|NA J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome MAG.T1.121_01053 479434.Sthe_1553 1e-240 839.7 Thermomicrobia pnp GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 Bacteria 27XQS@189775,2G5TS@200795,COG1185@1,COG1185@2 NA|NA|NA J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction MAG.T1.121_01055 1382356.JQMP01000003_gene2439 3.3e-71 275.4 Thermomicrobia oppC ko:K02034 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 27YY2@189775,2GBDG@200795,COG1173@1,COG1173@2 NA|NA|NA EP N-terminal TM domain of oligopeptide transport permease C MAG.T1.121_01056 1382356.JQMP01000003_gene2440 1.6e-102 379.4 Thermomicrobia appB GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0022857,GO:0051179,GO:0051234,GO:0055085 ko:K02033 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 27YUQ@189775,2GA2P@200795,COG0601@1,COG0601@2 NA|NA|NA EP Binding-protein-dependent transport system inner membrane component MAG.T1.121_01057 479434.Sthe_2927 3.1e-77 295.4 Thermomicrobia oppC ko:K02034,ko:K15582 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 27YY2@189775,2GBDG@200795,COG1173@1,COG1173@2 NA|NA|NA EP N-terminal TM domain of oligopeptide transport permease C MAG.T1.121_01058 1382356.JQMP01000003_gene2440 1.6e-92 346.3 Thermomicrobia appB GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0022857,GO:0051179,GO:0051234,GO:0055085 ko:K02033 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 27YUQ@189775,2GA2P@200795,COG0601@1,COG0601@2 NA|NA|NA EP Binding-protein-dependent transport system inner membrane component MAG.T1.121_01059 479434.Sthe_2925 3.7e-82 312.8 Thermomicrobia appA ko:K02035 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 27YVV@189775,2GA2U@200795,COG0747@1,COG0747@2 NA|NA|NA E Bacterial extracellular solute-binding proteins, family 5 Middle MAG.T1.121_01060 309801.trd_0620 7.2e-86 323.9 Chloroflexi larE ko:K06864 ko00000 Bacteria 2G6AU@200795,COG1606@1,COG1606@2 NA|NA|NA L tRNA processing MAG.T1.121_01061 1128421.JAGA01000002_gene1873 3.6e-25 121.3 unclassified Bacteria Bacteria 2NPZX@2323,COG1959@1,COG1959@2 NA|NA|NA K Transcriptional regulator MAG.T1.121_01062 479434.Sthe_0805 1.8e-201 708.8 Thermomicrobia ycbD 1.2.1.3 ko:K00128,ko:K22187 ko00010,ko00040,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00040,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146,R11768 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 Bacteria 27Y57@189775,2G5JZ@200795,COG1012@1,COG1012@2 NA|NA|NA C Belongs to the aldehyde dehydrogenase family MAG.T1.121_01063 1111479.AXAR01000008_gene2290 1.6e-35 156.4 Bacteria Bacteria COG4291@1,COG4291@2 NA|NA|NA C membrane MAG.T1.121_01064 440512.C211_18294 9.6e-50 203.4 Gammaproteobacteria Bacteria 1RDGV@1224,1S5VD@1236,COG5483@1,COG5483@2 NA|NA|NA S Protein of unknown function, DUF488 MAG.T1.121_01065 1229781.C272_05979 6e-26 122.9 Brevibacteriaceae Bacteria 2DP0W@1,2HYS6@201174,3302Q@2,4FAG5@85019 NA|NA|NA S Protein of unknown function (DUF2945) MAG.T1.121_01067 479434.Sthe_3451 3.1e-24 119.0 Thermomicrobia ywqE 3.1.3.48 ko:K01104 ko00000,ko01000 Bacteria 27YE0@189775,2G94G@200795,COG4464@1,COG4464@2 NA|NA|NA GM protein tyrosine phosphatase activity MAG.T1.121_01068 96561.Dole_2374 7.6e-116 423.7 Desulfobacterales mdh 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 Bacteria 1MV57@1224,2MJ7T@213118,2WJ4U@28221,42KZJ@68525,COG0039@1,COG0039@2 NA|NA|NA C Catalyzes the reversible oxidation of malate to oxaloacetate MAG.T1.121_01069 525904.Tter_1452 1.1e-53 217.6 unclassified Bacteria moeA 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 R09735 RC03462 ko00000,ko00001,ko01000 Bacteria 2NP4N@2323,COG0303@1,COG0303@2 NA|NA|NA H MoeA N-terminal region (domain I and II) MAG.T1.121_01070 479434.Sthe_1114 3.3e-50 205.7 Chloroflexi ycgC ko:K03595,ko:K06883,ko:K06946 ko00000,ko03009,ko03029 Bacteria 2G9CM@200795,COG3597@1,COG3597@2 NA|NA|NA S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism MAG.T1.121_01071 525904.Tter_0470 2.8e-134 485.3 unclassified Bacteria glpK GO:0003674,GO:0003824,GO:0004370,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019405,GO:0019563,GO:0019751,GO:0033554,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046164,GO:0046174,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:1901575,GO:1901615,GO:1901616 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 iE2348C_1286.E2348C_4230,iECNA114_1301.ECNA114_4065,iECSF_1327.ECSF_3786 Bacteria 2NNPX@2323,COG0554@1,COG0554@2 NA|NA|NA C Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate MAG.T1.121_01072 479434.Sthe_1116 1.2e-120 440.7 Thermomicrobia aroK GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71,4.2.3.4 ko:K00891,ko:K01735,ko:K13829,ko:K15546 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412,R03083 RC00002,RC00078,RC00847 ko00000,ko00001,ko00002,ko01000,ko03000 iAPECO1_1312.APECO1_1620,iECOK1_1307.ECOK1_0367,iECS88_1305.ECS88_0383,iUMN146_1321.UM146_15425,iUTI89_1310.UTI89_C0407,iYL1228.KPN_00332 Bacteria 27XTZ@189775,2G5K8@200795,COG0337@1,COG0337@2,COG0703@1,COG0703@2 NA|NA|NA H Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) MAG.T1.121_01073 1382356.JQMP01000004_gene624 2.2e-76 293.5 Thermomicrobia ko:K02035 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 27XM9@189775,2G860@200795,COG0747@1,COG0747@2 NA|NA|NA E Bacterial extracellular solute-binding proteins, family 5 Middle MAG.T1.121_01074 1382356.JQMP01000004_gene623 4.2e-96 358.2 Thermomicrobia ko:K02033 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 27XXY@189775,2G7SK@200795,COG0601@1,COG0601@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component MAG.T1.121_01075 1382356.JQMP01000004_gene622 6.2e-83 314.3 Thermomicrobia ko:K02034 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 27XKI@189775,2G6HB@200795,COG1173@1,COG1173@2 NA|NA|NA EP Binding-protein-dependent transport system inner membrane component MAG.T1.121_01076 378806.STAUR_4854 2.5e-22 112.1 Bacteria ko:K03976 ko00000,ko01000,ko03016 Bacteria COG2606@1,COG2606@2 NA|NA|NA S Cys-tRNA(Pro) hydrolase activity MAG.T1.121_01077 479434.Sthe_0322 2.1e-133 482.3 Thermomicrobia ychF ko:K06942 ko00000,ko03009 Bacteria 27XGT@189775,2G5UY@200795,COG0012@1,COG0012@2 NA|NA|NA J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner MAG.T1.121_01079 309801.trd_0106 3e-45 188.7 Thermomicrobia trpF GO:0000162,GO:0003674,GO:0003824,GO:0004425,GO:0004640,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.48,4.2.1.160,4.2.1.20,5.3.1.24 ko:K01696,ko:K01817,ko:K13498,ko:K22100 ko00260,ko00400,ko00790,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map00790,map01100,map01110,map01130,map01230 M00023,M00840 R00674,R02340,R02722,R03508,R03509,R11072 RC00209,RC00210,RC00700,RC00701,RC00944,RC00945,RC02868,RC03343 ko00000,ko00001,ko00002,ko01000 iJN678.trpF,iPC815.YPO2205,iSBO_1134.SBO_1804,iSDY_1059.SDY_1330 Bacteria 27YDR@189775,2G6QB@200795,COG0135@1,COG0135@2 NA|NA|NA E N-(5'phosphoribosyl)anthranilate (PRA) isomerase MAG.T1.121_01080 1382356.JQMP01000004_gene439 1.7e-66 259.6 Thermomicrobia trpC 4.1.1.48,5.3.1.24 ko:K01609,ko:K13498 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508,R03509 RC00944,RC00945 ko00000,ko00001,ko00002,ko01000 Bacteria 27XGP@189775,2G6GG@200795,COG0134@1,COG0134@2 NA|NA|NA E Indole-3-glycerol phosphate synthase MAG.T1.121_01081 479434.Sthe_1876 8.4e-92 344.0 Thermomicrobia trpD GO:0000162,GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0004048,GO:0004049,GO:0004425,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0016829,GO:0016830,GO:0016831,GO:0016833,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042401,GO:0042430,GO:0042435,GO:0042451,GO:0042455,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046219,GO:0046390,GO:0046394,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901657,GO:1901659,GO:1902494 2.4.2.18,4.1.3.27 ko:K00766,ko:K13497 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R00985,R00986,R01073 RC00010,RC00440,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2495,iJN746.PP_0421,iSBO_1134.SBO_1803,iSbBS512_1146.SbBS512_E1488,iYL1228.KPN_01256 Bacteria 27XT8@189775,2G5YV@200795,COG0547@1,COG0547@2 NA|NA|NA F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) MAG.T1.121_01082 485913.Krac_10779 3.9e-73 281.2 Chloroflexi trpG 2.4.2.18,2.6.1.85,4.1.3.27 ko:K01658,ko:K01664,ko:K13497 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01073,R01716 RC00010,RC00440,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 Bacteria 2G69G@200795,COG0512@1,COG0512@2 NA|NA|NA EH TIGRFAM glutamine amidotransferase of anthranilate synthase MAG.T1.121_01083 479434.Sthe_1878 6.7e-106 390.6 Thermomicrobia trpE GO:0000162,GO:0003674,GO:0003824,GO:0004049,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 Bacteria 27XZ8@189775,2G5M7@200795,COG0147@1,COG0147@2 NA|NA|NA H Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia MAG.T1.121_01085 865861.AZSU01000001_gene116 7.2e-96 357.5 Clostridiaceae appD ko:K02031,ko:K02032 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 1TP6E@1239,247NN@186801,36DZS@31979,COG0444@1,COG0444@2 NA|NA|NA P Belongs to the ABC transporter superfamily MAG.T1.121_01086 1227352.C173_19136 5.6e-68 264.6 Paenibacillaceae dppCch3 ko:K02034 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 1TP4R@1239,26Q9W@186822,4HBB9@91061,COG1173@1,COG1173@2 NA|NA|NA EP ABC transporter permease MAG.T1.121_01087 1297863.APJF01000019_gene2402 1.2e-84 320.1 Bradyrhizobiaceae MA20_22705 ko:K02033 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 1MU8Z@1224,2TQKK@28211,3JQUZ@41294,COG0601@1,COG0601@2 NA|NA|NA EP Binding-protein-dependent transport system inner membrane component MAG.T1.121_01088 1536769.P40081_24240 1.4e-72 280.8 Paenibacillaceae ko:K02035 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 1TQ6S@1239,26TIQ@186822,4HAM7@91061,COG0747@1,COG0747@2 NA|NA|NA E ABC transporter substrate-binding protein MAG.T1.121_01089 1121422.AUMW01000002_gene2228 9.2e-175 620.5 Clostridia oplaH 3.5.2.14,3.5.2.9 ko:K01469,ko:K01473 ko00330,ko00480,ko01100,map00330,map00480,map01100 R00251,R03187 RC00553,RC00632 ko00000,ko00001,ko01000 Bacteria 1TQVB@1239,24AJ7@186801,COG0145@1,COG0145@2 NA|NA|NA EQ PFAM Hydantoinase oxoprolinase MAG.T1.121_01090 311402.Avi_5833 3.2e-160 572.0 Rhizobiaceae huyB 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 R03187 RC00632 ko00000,ko00001,ko01000 Bacteria 1QU46@1224,2TVYU@28211,4B8UI@82115,COG0146@1,COG0146@2 NA|NA|NA EQ N-methylhydantoinase B acetone carboxylase, alpha subunit MAG.T1.121_01091 309801.trd_0696 1.1e-57 230.3 Thermomicrobia 2.1.1.185,2.1.1.34 ko:K00556,ko:K03218,ko:K03437 ko00000,ko01000,ko03009,ko03016 Bacteria 27XUH@189775,2G6FR@200795,COG0566@1,COG0566@2 NA|NA|NA J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family MAG.T1.121_01092 324602.Caur_1840 2.3e-153 548.9 Chloroflexia cysS GO:0000166,GO:0001871,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030246,GO:0030247,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065 6.1.1.16,6.3.1.13 ko:K01883,ko:K15526 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iECUMN_1333.ECUMN_0566,iJN746.PP_2905 Bacteria 2G5Z0@200795,3756I@32061,COG0215@1,COG0215@2 NA|NA|NA J Belongs to the class-I aminoacyl-tRNA synthetase family MAG.T1.121_01093 357808.RoseRS_3035 9.3e-68 263.5 Chloroflexia cysE GO:0000096,GO:0000097,GO:0000098,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009001,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009070,GO:0009087,GO:0009987,GO:0016053,GO:0016054,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS02865,iYO844.BSU00930 Bacteria 2G6DI@200795,374UH@32061,COG1045@1,COG1045@2 NA|NA|NA E TIGRFAM serine O-acetyltransferase MAG.T1.121_01094 316274.Haur_3106 6.2e-19 100.1 Chloroflexia fmdB Bacteria 2G752@200795,375YG@32061,COG2331@1,COG2331@2 NA|NA|NA S regulatory protein, FmdB family MAG.T1.121_01095 309801.trd_0700 2.6e-273 948.3 Thermomicrobia polA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 Bacteria 27Y2S@189775,2G5J0@200795,COG0258@1,COG0258@2,COG0749@1,COG0749@2 NA|NA|NA L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity MAG.T1.121_01096 479434.Sthe_1590 7.2e-122 443.7 Thermomicrobia moxR1 ko:K03924 ko00000,ko01000 Bacteria 27XT7@189775,2G66D@200795,COG0714@1,COG0714@2 NA|NA|NA S ATPase family associated with various cellular activities (AAA) MAG.T1.121_01097 479434.Sthe_1589 1.5e-66 260.4 Thermomicrobia Bacteria 27XZ3@189775,2G5XH@200795,COG1721@1,COG1721@2 NA|NA|NA S Protein of unknown function DUF58 MAG.T1.121_01098 479434.Sthe_1588 7.1e-76 292.4 Thermomicrobia Bacteria 27XNH@189775,2G66M@200795,COG1305@1,COG1305@2 NA|NA|NA E Transglutaminase/protease-like homologues MAG.T1.121_01099 1155718.KB891894_gene7139 6.1e-54 218.0 Actinobacteria rbsK 2.7.1.15 ko:K00852 ko00030,map00030 R01051,R02750 RC00002,RC00017 ko00000,ko00001,ko01000 Bacteria 2I04R@201174,COG0524@1,COG0524@2 NA|NA|NA G Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway MAG.T1.121_01102 292563.Cyast_1391 2.6e-06 60.8 Cyanobacteria 2.4.2.43 ko:K07264 ko01503,map01503 M00721 R09773,R09774,R09781 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 Bacteria 1G424@1117,COG1807@1,COG1807@2 NA|NA|NA M glycosyl transferase, family 39 MAG.T1.121_01106 59538.XP_005968778.1 6.4e-111 407.5 Mammalia Mammalia 397PJ@33154,3BIQH@33208,3CYWE@33213,3J1Y5@40674,4871P@7711,491PB@7742,COG1062@1,KOG0022@2759 NA|NA|NA Q alcohol dehydrogenase (NAD) activity MAG.T1.121_01108 1120972.AUMH01000021_gene2280 5.5e-161 574.3 Bacilli abfA 3.2.1.55 ko:K01209 ko00520,map00520 R01762 ko00000,ko00001,ko01000 GH51 Bacteria 1TRY9@1239,4HAZ7@91061,COG3534@1,COG3534@2 NA|NA|NA G alpha-N-arabinofuranosidase MAG.T1.121_01109 671143.DAMO_1252 1.2e-103 384.0 unclassified Bacteria ybaL GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03455 ko00000 2.A.37 Bacteria 2NNZ0@2323,COG1226@1,COG1226@2,COG4651@1,COG4651@2 NA|NA|NA P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family MAG.T1.121_01110 546414.Deide_16200 8.7e-30 137.1 Deinococcus-Thermus rimL 2.3.1.128 ko:K03790 ko00000,ko01000,ko03009 Bacteria 1WN9C@1297,COG1670@1,COG1670@2 NA|NA|NA J Acetyltransferase (GNAT) domain MAG.T1.121_01111 1382356.JQMP01000003_gene2446 2e-110 406.0 Thermomicrobia 3.4.11.19 ko:K01266 ko00000,ko01000,ko01002 Bacteria 27YT6@189775,2G83F@200795,COG3191@1,COG3191@2 NA|NA|NA EQ Peptidase family S58 MAG.T1.121_01112 266117.Rxyl_0960 7.9e-137 493.8 Rubrobacteria aroG 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 Bacteria 2GMVF@201174,4CSEZ@84995,COG0722@1,COG0722@2 NA|NA|NA E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) MAG.T1.121_01114 525904.Tter_1524 5.4e-235 820.5 unclassified Bacteria iolD GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009395,GO:0009987,GO:0016042,GO:0019637,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0046434,GO:0071704,GO:1901575 3.7.1.22 ko:K03336 ko00562,ko01100,ko01120,map00562,map01100,map01120 R08603 RC02331 ko00000,ko00001,ko01000 iYO844.BSU39730 Bacteria 2NQB0@2323,COG3962@1,COG3962@2 NA|NA|NA E Thiamine pyrophosphate enzyme, central domain MAG.T1.121_01115 234267.Acid_1480 8.5e-69 267.3 Bacteria iolB 5.3.1.30 ko:K03337 ko00562,ko01100,ko01120,map00562,map01100,map01120 R08503 RC00541 ko00000,ko00001,ko01000 Bacteria COG3718@1,COG3718@2 NA|NA|NA G enzyme involved in inositol metabolism MAG.T1.121_01116 525904.Tter_1526 6.5e-81 307.8 unclassified Bacteria idhA 1.1.1.18,1.1.1.369 ko:K00010 ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130 R01183,R09951 RC00182 ko00000,ko00001,ko01000 iYL1228.KPN_00507 Bacteria 2NQJN@2323,COG0673@1,COG0673@2 NA|NA|NA S Oxidoreductase family, C-terminal alpha/beta domain MAG.T1.121_01117 309801.trd_A0657 5.5e-70 271.2 Thermomicrobia ama ko:K01436,ko:K12941 ko00000,ko01000,ko01002 Bacteria 27XWM@189775,2G5WT@200795,COG1473@1,COG1473@2 NA|NA|NA S Peptidase dimerisation domain MAG.T1.121_01118 525904.Tter_1937 4.6e-109 401.4 Bacteria Bacteria COG0673@1,COG0673@2 NA|NA|NA S inositol 2-dehydrogenase activity MAG.T1.121_01119 1122138.AQUZ01000073_gene4428 5e-28 130.6 Propionibacteriales rlmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042802,GO:0042803,GO:0043021,GO:0043022,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0044877,GO:0046483,GO:0046983,GO:0070037,GO:0070038,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.177 ko:K00783 ko00000,ko01000,ko03009 Bacteria 2IGAN@201174,4DVE4@85009,COG1576@1,COG1576@2,COG3631@1,COG3631@2 NA|NA|NA J Mycothiol maleylpyruvate isomerase N-terminal domain MAG.T1.121_01120 742738.HMPREF9460_00523 5.2e-54 218.4 unclassified Clostridiales Bacteria 1TQ72@1239,24NIH@186801,269X0@186813,COG0673@1,COG0673@2 NA|NA|NA S Oxidoreductase family, NAD-binding Rossmann fold MAG.T1.121_01121 378806.STAUR_5730 5.8e-94 351.7 Myxococcales pepA GO:0001073,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006351,GO:0006355,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009056,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016787,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019538,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042150,GO:0042802,GO:0043170,GO:0043171,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043244,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0097718,GO:0140096,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1903506,GO:2000112,GO:2001141 3.4.11.1,3.4.11.23,3.4.11.5 ko:K01255,ko:K01259,ko:K07751 ko00330,ko00480,ko01100,map00330,map00480,map01100 R00135,R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 iAF1260.b2523,iBWG_1329.BWG_2287,iECDH10B_1368.ECDH10B_2690,iECDH1ME8569_1439.ECDH1ME8569_2450,iEcDH1_1363.EcDH1_1145,iJO1366.b2523,iY75_1357.Y75_RS13170 Bacteria 1MUF9@1224,2WJ80@28221,2YUN7@29,42M2G@68525,COG0260@1,COG0260@2 NA|NA|NA E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides MAG.T1.121_01122 479434.Sthe_2524 1.7e-72 279.3 Chloroflexi hadL 3.8.1.2 ko:K01560,ko:K07025 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 R05287 RC00697 ko00000,ko00001,ko01000 Bacteria 2G916@200795,COG1011@1,COG1011@2 NA|NA|NA S PFAM Haloacid dehalogenase domain protein hydrolase MAG.T1.121_01123 2045.KR76_25535 1.9e-14 85.5 Actinobacteria ko:K06995 ko00000 Bacteria 2IKAE@201174,COG3450@1,COG3450@2 NA|NA|NA S Protein of unknown function (DUF861) MAG.T1.121_01124 926554.KI912674_gene2643 3.6e-69 270.0 Bacteria GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.7.11.1 ko:K08282,ko:K13419 ko00000,ko01000,ko01001 Bacteria COG2197@1,COG2197@2,COG3903@1,COG3903@2 NA|NA|NA K ADP binding MAG.T1.121_01127 479434.Sthe_2284 1e-235 823.2 Thermomicrobia 1.1.1.399,1.1.1.95,2.6.1.9,3.1.3.10,3.8.1.2 ko:K00058,ko:K00817,ko:K01560,ko:K07025,ko:K20866 ko00010,ko00260,ko00340,ko00350,ko00360,ko00361,ko00400,ko00401,ko00625,ko00680,ko00960,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00340,map00350,map00360,map00361,map00400,map00401,map00625,map00680,map00960,map01100,map01110,map01120,map01130,map01200,map01230 M00020,M00026 R00694,R00734,R00947,R01513,R03243,R05287 RC00006,RC00031,RC00078,RC00697,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007,ko04147 Bacteria 27XG7@189775,2G67B@200795,COG0111@1,COG0111@2,COG0637@1,COG0637@2 NA|NA|NA C D-isomer specific 2-hydroxyacid dehydrogenase MAG.T1.121_01128 525904.Tter_2143 2.6e-25 121.7 Bacteria ko:K07005 ko00000 Bacteria COG3576@1,COG3576@2 NA|NA|NA S Pyridoxamine 5'-phosphate oxidase MAG.T1.121_01129 479434.Sthe_1100 1.2e-109 403.3 Thermomicrobia serA Bacteria 27XG7@189775,2G67B@200795,COG0111@1,COG0111@2 NA|NA|NA C D-isomer specific 2-hydroxyacid dehydrogenase MAG.T1.121_01130 1040987.AZUY01000009_gene1142 2.3e-30 138.7 Alphaproteobacteria Bacteria 1RKHC@1224,2UHIW@28211,COG5573@1,COG5573@2 NA|NA|NA S nucleic-acid-binding protein contains PIN domain MAG.T1.121_01132 1229780.BN381_80376 3e-143 515.4 unclassified Actinobacteria (class) nirK 1.7.2.1 ko:K00368 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 Bacteria 2HZAX@201174,3UXS1@52018,COG2132@1,COG2132@2,COG3794@1,COG3794@2 NA|NA|NA C Copper binding proteins, plastocyanin/azurin family MAG.T1.121_01133 479434.Sthe_0524 6.3e-114 417.5 Thermomicrobia pepE 3.4.13.9 ko:K01271,ko:K01274 ko00000,ko01000,ko01002 Bacteria 27XJK@189775,2G6AH@200795,COG0006@1,COG0006@2 NA|NA|NA E Creatinase/Prolidase N-terminal domain MAG.T1.121_01134 202954.BBNK01000031_gene3711 1.9e-74 285.8 Moraxellaceae Bacteria 1R413@1224,1S3TR@1236,3NMP9@468,COG1028@1,COG1028@2 NA|NA|NA IQ KR domain MAG.T1.121_01135 479434.Sthe_0589 5.2e-190 671.0 Thermomicrobia ko:K01420 ko00000,ko03000 Bacteria 27YV2@189775,2G63K@200795,COG0664@1,COG0664@2 NA|NA|NA T - Catabolite gene activator and regulatory subunit of cAMP-dependent protein MAG.T1.121_01136 1229780.BN381_70028 2.1e-13 82.4 Actinobacteria MA20_19755 Bacteria 2HCSH@201174,COG5349@1,COG5349@2 NA|NA|NA S Protein of unknown function (DUF983) MAG.T1.121_01137 324602.Caur_3563 9.6e-74 284.3 Chloroflexia entS ko:K08225 ko00000,ko02000 2.A.1.38 Bacteria 2GBHK@200795,376GU@32061,COG0477@1,COG2814@2 NA|NA|NA EGP major facilitator superfamily MFS_1 MAG.T1.121_01138 1382356.JQMP01000004_gene117 7.4e-16 91.7 Thermomicrobia 3.5.1.28 ko:K01448,ko:K02172 ko01501,ko01503,map01501,map01503 M00627,M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504,ko03036 Bacteria 27Z4E@189775,2G9MY@200795,COG0860@1,COG0860@2 NA|NA|NA M Ami_3 MAG.T1.121_01139 479434.Sthe_1010 2.1e-87 329.7 Thermomicrobia pstS ko:K02040,ko:K07282 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 ko00000,ko00001,ko00002,ko02000 3.A.1.7 Bacteria 27Z2P@189775,2G78I@200795,COG0226@1,COG0226@2,COG2843@1,COG2843@2 NA|NA|NA M Bacterial capsule synthesis protein PGA_cap MAG.T1.121_01140 485913.Krac_0922 1.1e-11 76.3 Bacteria Bacteria COG0662@1,COG0662@2 NA|NA|NA G Cupin 2, conserved barrel domain protein MAG.T1.121_01144 485913.Krac_9158 7.1e-69 267.7 Chloroflexi ilvA 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 iLJ478.TM0356 Bacteria 2G69F@200795,COG1171@1,COG1171@2 NA|NA|NA E PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit MAG.T1.121_01145 926564.KI911742_gene3318 2.9e-44 186.4 Actinobacteria ko:K02027 M00207 ko00000,ko00002,ko02000 3.A.1.1 Bacteria 2I3WZ@201174,COG1653@1,COG1653@2 NA|NA|NA G Extracellular solute-binding protein MAG.T1.121_01146 926564.KI911742_gene3318 1.7e-37 163.7 Actinobacteria ko:K02027 M00207 ko00000,ko00002,ko02000 3.A.1.1 Bacteria 2I3WZ@201174,COG1653@1,COG1653@2 NA|NA|NA G Extracellular solute-binding protein MAG.T1.121_01147 1122238.AULR01000003_gene1351 3.1e-45 189.1 Microbacteriaceae ko:K02025,ko:K15771 ko02010,map02010 M00207,M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.2 Bacteria 2GNCE@201174,4FKXC@85023,COG1175@1,COG1175@2 NA|NA|NA G Binding-protein-dependent transport system inner membrane component MAG.T1.121_01148 1500259.JQLD01000002_gene2926 3e-39 169.1 Rhizobiaceae ko:K02026,ko:K15772 ko02010,map02010 M00207,M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.2 Bacteria 1N12U@1224,2UD0Z@28211,4BAPK@82115,COG0395@1,COG0395@2 NA|NA|NA G Binding-protein-dependent transport system inner membrane component MAG.T1.121_01150 1132509.C447_16992 2.6e-41 176.0 Halobacteria Archaea 23WMZ@183963,2DZBC@1,2N5Z6@2157,2XY3I@28890 NA|NA|NA MAG.T1.121_01151 1223523.H340_30798 8.8e-35 154.1 Actinobacteria Bacteria 29SM8@1,2H3BM@201174,30DSN@2 NA|NA|NA MAG.T1.121_01152 309801.trd_1301 2.5e-31 141.4 Thermomicrobia groS GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 ko:K04078 ko00000,ko03029,ko03110 Bacteria 27YJ2@189775,2G6WW@200795,COG0234@1,COG0234@2 NA|NA|NA O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter MAG.T1.121_01153 309801.trd_1909 3.5e-118 431.8 Thermomicrobia cysS GO:0000166,GO:0001871,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030246,GO:0030247,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065 6.1.1.16,6.3.1.13 ko:K01883,ko:K15526 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iECUMN_1333.ECUMN_0566,iJN746.PP_2905 Bacteria 27XXR@189775,2G5Z0@200795,COG0215@1,COG0215@2 NA|NA|NA J Belongs to the class-I aminoacyl-tRNA synthetase family MAG.T1.121_01155 479434.Sthe_1104 2.3e-44 186.0 Thermomicrobia otsB 3.1.3.12 ko:K01087 ko00500,ko01100,map00500,map01100 R02778 RC00017 ko00000,ko00001,ko01000 Bacteria 27YHH@189775,2G6X2@200795,COG1877@1,COG1877@2 NA|NA|NA G Removes the phosphate from trehalose 6-phosphate to produce free trehalose MAG.T1.121_01156 309801.trd_0162 3e-50 205.3 Thermomicrobia ko:K07477 ko00000 Bacteria 27Y62@189775,2G6RW@200795,COG2178@1,COG2178@2 NA|NA|NA J PFAM Translin MAG.T1.121_01158 1120959.ATXF01000005_gene1524 3e-139 502.3 Microbacteriaceae ko:K03316 ko00000 2.A.36 Bacteria 2GIUT@201174,4FKF3@85023,COG0025@1,COG0025@2 NA|NA|NA P Sodium/hydrogen exchanger family MAG.T1.121_01159 479434.Sthe_1438 0.0 1098.2 Thermomicrobia leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 Bacteria 27XYD@189775,2G5MX@200795,COG0495@1,COG0495@2 NA|NA|NA J Belongs to the class-I aminoacyl-tRNA synthetase family MAG.T1.121_01160 479434.Sthe_0897 3.5e-192 677.9 Thermomicrobia gcvPB GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019464,GO:0019752,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204 1.4.4.2 ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 iHN637.CLJU_RS11880 Bacteria 27XMZ@189775,2G5MU@200795,COG1003@1,COG1003@2 NA|NA|NA E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor MAG.T1.121_01162 543632.JOJL01000007_gene5210 7e-22 111.7 Micromonosporales Bacteria 2IAXK@201174,4DA2G@85008,COG0671@1,COG0671@2 NA|NA|NA I PAP2 superfamily MAG.T1.121_01163 479434.Sthe_3160 4.4e-41 174.5 Thermomicrobia Bacteria 27YC7@189775,2GA0H@200795,COG3411@1,COG3411@2 NA|NA|NA C Ferredoxin MAG.T1.121_01164 479434.Sthe_3159 9e-40 169.5 Thermomicrobia fixX ko:K03855 ko00000 Bacteria 27YFB@189775,2G7FT@200795,COG2440@1,COG2440@2 NA|NA|NA C Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S MAG.T1.121_01165 479434.Sthe_0719 2.1e-61 243.0 Thermomicrobia Bacteria 27XPY@189775,2G6SD@200795,COG0308@1,COG0308@2 NA|NA|NA E Peptidase MA superfamily MAG.T1.121_01166 479434.Sthe_0720 8.8e-112 410.2 Thermomicrobia prfB GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02836 ko00000,ko03012 Bacteria 27XS7@189775,2G5P6@200795,COG1186@1,COG1186@2 NA|NA|NA J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA MAG.T1.121_01169 1382356.JQMP01000003_gene2142 1.5e-58 233.0 Thermomicrobia parB ko:K03497 ko00000,ko03000,ko03036,ko04812 Bacteria 27XFW@189775,2G6EK@200795,COG1475@1,COG1475@2 NA|NA|NA K ParB-like nuclease domain MAG.T1.121_01170 1382356.JQMP01000003_gene2143 5.5e-50 204.9 Thermomicrobia ko:K07052 ko00000 Bacteria 27YGJ@189775,2G9FI@200795,COG1266@1,COG1266@2 NA|NA|NA S CAAX protease self-immunity MAG.T1.121_01171 1298863.AUEP01000005_gene2400 2.1e-94 353.2 Propionibacteriales murE 6.3.2.13,6.3.2.29,6.3.2.30 ko:K01928,ko:K03802 ko00300,ko00550,map00300,map00550 R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 Bacteria 2GME3@201174,4DPYG@85009,COG0769@1,COG0769@2 NA|NA|NA M Mur ligase middle domain MAG.T1.121_01172 110319.CF8_2111 4.8e-261 907.5 Propionibacteriales cphA 6.3.2.13,6.3.2.29,6.3.2.30 ko:K01928,ko:K03802 ko00300,ko00550,map00300,map00550 R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 Bacteria 2GN0U@201174,4DP39@85009,COG0189@1,COG0189@2,COG0769@1,COG0769@2 NA|NA|NA HJM RimK-like ATP-grasp domain MAG.T1.121_01173 1032480.MLP_14770 1.4e-57 229.9 Propionibacteriales cphB GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0042802,GO:0042803,GO:0043170,GO:0044238,GO:0046983,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.15.6 ko:K13282 R09722 RC00064,RC00141 ko00000,ko01000,ko01002 iJN678.slr2001 Bacteria 2I93U@201174,4DP1Z@85009,COG4242@1,COG4242@2 NA|NA|NA PQ Peptidase family S51 MAG.T1.121_01174 1382356.JQMP01000003_gene2013 7.5e-59 234.2 Thermomicrobia Bacteria 27Y54@189775,2G8NG@200795,COG2141@1,COG2141@2 NA|NA|NA C Luciferase-like monooxygenase MAG.T1.121_01175 309801.trd_1049 5.8e-200 704.1 Thermomicrobia yitJ 1.5.1.20,2.1.1.10,2.1.1.13 ko:K00297,ko:K00547,ko:K00548 ko00270,ko00450,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01230,ko01523,map00270,map00450,map00670,map00720,map01100,map01110,map01120,map01200,map01230,map01523 M00017,M00377 R00650,R00946,R01224,R07168,R09365 RC00003,RC00035,RC00081,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_0504 Bacteria 27Z2G@189775,2G674@200795,COG0646@1,COG0646@2,COG0685@1,COG0685@2 NA|NA|NA E Homocysteine S-methyltransferase MAG.T1.121_01176 479434.Sthe_0471 1.1e-42 179.9 Thermomicrobia rplS GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02884 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 27YD2@189775,2G6W0@200795,COG0335@1,COG0335@2 NA|NA|NA J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site MAG.T1.121_01177 1382306.JNIM01000001_gene3760 7.7e-40 170.6 Chloroflexi rnhB GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 ko:K03470 ko03030,map03030 ko00000,ko00001,ko01000,ko03032 Bacteria 2G6KR@200795,COG0164@1,COG0164@2 NA|NA|NA L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids MAG.T1.121_01178 1382356.JQMP01000003_gene2149 2.6e-21 108.2 Thermomicrobia yraN ko:K07460 ko00000 Bacteria 27YNS@189775,2G7AR@200795,COG0792@1,COG0792@2 NA|NA|NA L Uncharacterised protein family UPF0102 MAG.T1.121_01179 42256.RradSPS_1118 3e-47 194.9 Rubrobacteria moaB 2.7.7.75 ko:K03638 ko00790,ko01100,map00790,map01100 R09726 RC00002 ko00000,ko00001,ko01000 Bacteria 2II28@201174,4CR10@84995,COG0521@1,COG0521@2 NA|NA|NA H May be involved in the biosynthesis of molybdopterin MAG.T1.121_01180 479434.Sthe_0476 9e-117 427.2 Thermomicrobia hisS 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 27XH4@189775,2G64E@200795,COG0124@1,COG0124@2 NA|NA|NA J Histidyl-tRNA synthetase MAG.T1.121_01181 1382356.JQMP01000003_gene2153 7.4e-76 290.4 Thermomicrobia Bacteria 27XV7@189775,2G6FB@200795,COG2120@1,COG2120@2 NA|NA|NA S GlcNAc-PI de-N-acetylase MAG.T1.121_01182 30611.ENSOGAP00000001709 7.4e-39 168.3 Primates GALK1 GO:0000166,GO:0003674,GO:0003824,GO:0004335,GO:0005488,GO:0005524,GO:0005534,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006012,GO:0006059,GO:0006066,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0017144,GO:0018130,GO:0019200,GO:0019318,GO:0019320,GO:0019359,GO:0019362,GO:0019363,GO:0019388,GO:0019400,GO:0019402,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019751,GO:0019752,GO:0030246,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033499,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035639,GO:0036094,GO:0042866,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046365,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046835,GO:0046939,GO:0048029,GO:0051186,GO:0051188,GO:0055086,GO:0061615,GO:0061620,GO:0061622,GO:0061623,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615 2.7.1.6 ko:K00849 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00554,M00632 R01092 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko04147 Mammalia 35I91@314146,38HFX@33154,3BGCU@33208,3CWGJ@33213,3JFIF@40674,4835A@7711,494MW@7742,4M8C3@9443,COG0153@1,KOG0631@2759 NA|NA|NA G Galactokinase 1 MAG.T1.121_01183 479434.Sthe_3043 2e-60 239.6 Bacteria Bacteria COG0111@1,COG0111@2 NA|NA|NA EH 4-phosphoerythronate dehydrogenase activity MAG.T1.121_01184 479434.Sthe_0481 8.5e-129 466.8 Thermomicrobia moaA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0030312,GO:0040007,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0071944,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.22,4.6.1.17 ko:K03639,ko:K20967 ko00790,ko01100,ko04122,map00790,map01100,map04122 R09394,R11372 RC03420,RC03425 ko00000,ko00001,ko01000 Bacteria 27Y22@189775,2G5JT@200795,COG2896@1,COG2896@2 NA|NA|NA H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate MAG.T1.121_01185 1382356.JQMP01000001_gene1264 4.6e-43 181.0 Thermomicrobia dcd 3.5.4.13,3.6.1.23 ko:K01494,ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R00568,R02100,R02325,R11896 RC00002,RC00074 ko00000,ko00001,ko00002,ko01000,ko03400 Bacteria 27YDB@189775,2G8PG@200795,COG0717@1,COG0717@2 NA|NA|NA F dUTPase MAG.T1.121_01187 886293.Sinac_1347 1.3e-23 115.9 Planctomycetes fdx5 ko:K04755 ko00000 Bacteria 2J0FV@203682,COG0633@1,COG0633@2 NA|NA|NA C 2Fe-2S iron-sulfur cluster binding domain MAG.T1.121_01188 479434.Sthe_1987 1.8e-128 466.1 Thermomicrobia ftsZ GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 ko:K03531 ko04112,map04112 ko00000,ko00001,ko02048,ko03036,ko04812 Bacteria 27XQV@189775,2G5V2@200795,COG0206@1,COG0206@2 NA|NA|NA D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity MAG.T1.121_01189 479434.Sthe_1986 3.5e-50 204.5 Thermomicrobia nrdR GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 ko:K07738 ko00000,ko03000 Bacteria 27YBF@189775,2G6QI@200795,COG1327@1,COG1327@2 NA|NA|NA K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes MAG.T1.121_01190 479434.Sthe_3462 2.9e-46 191.8 Chloroflexi Bacteria 2G99R@200795,COG1695@1,COG1695@2 NA|NA|NA K Transcriptional regulator PadR-like family MAG.T1.121_01191 479434.Sthe_3461 6.4e-58 231.5 Chloroflexi hrtB ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 2G6RX@200795,COG0577@1,COG0577@2 NA|NA|NA V MacB-like periplasmic core domain MAG.T1.121_01192 1341151.ASZU01000014_gene2208 1.4e-66 259.6 Thermoactinomycetaceae hrtA 3.6.3.25 ko:K02003,ko:K06020,ko:K09810,ko:K09814 ko02010,map02010 M00255,M00257,M00258 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.125 Bacteria 1TQP5@1239,27BPH@186824,4HBXK@91061,COG1136@1,COG1136@2 NA|NA|NA V ATPases associated with a variety of cellular activities MAG.T1.121_01193 479434.Sthe_0148 1.2e-31 142.5 Thermomicrobia trxA ko:K03671,ko:K05838 ko04621,ko05418,map04621,map05418 ko00000,ko00001,ko03110 iIT341.HP0824 Bacteria 27YE3@189775,2G6U1@200795,COG3118@1,COG3118@2 NA|NA|NA O Thioredoxin-like domain MAG.T1.121_01194 309801.trd_0088 1.2e-64 253.8 Thermomicrobia Bacteria 27XJ4@189775,2G7W6@200795,COG0438@1,COG0438@2 NA|NA|NA M Glycosyl transferase 4-like domain MAG.T1.121_01196 67267.JNXT01000063_gene46 2.8e-12 80.5 Actinobacteria ko:K03406 ko02020,ko02030,map02020,map02030 ko00000,ko00001,ko02035 Bacteria 2IEDD@201174,COG0840@1,COG0840@2 NA|NA|NA NT transmembrane signaling receptor activity MAG.T1.121_01197 326424.FRAAL6482 2.7e-18 100.9 Actinobacteria Bacteria 2I99Y@201174,COG0515@1,COG0515@2 NA|NA|NA KLT Membrane MAG.T1.121_01198 326427.Cagg_0077 1.5e-102 379.8 Chloroflexia 1.3.8.6 ko:K00252 ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130 M00032 R02487,R02488,R10074 RC00052,RC00156 ko00000,ko00001,ko00002,ko01000 Bacteria 2G7JH@200795,3769E@32061,COG1960@1,COG1960@2 NA|NA|NA C Acyl-CoA dehydrogenase type 2 domain MAG.T1.121_01199 986075.CathTA2_1195 3e-58 232.3 Bacilli 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 Bacteria 1TPA4@1239,4HEAF@91061,COG1250@1,COG1250@2 NA|NA|NA I 3-hydroxyacyl-CoA dehydrogenase MAG.T1.121_01200 357808.RoseRS_2631 5.9e-46 192.2 Chloroflexia 2.7.11.1 ko:K08884,ko:K12132 ko00000,ko01000,ko01001 Bacteria 2G67H@200795,374SX@32061,COG0515@1,COG0515@2,COG2815@1,COG2815@2 NA|NA|NA KLT Serine threonine protein kinase MAG.T1.121_01201 1356854.N007_19525 1.1e-64 253.4 Bacilli paaF GO:0003674,GO:0003824,GO:0004300,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0030312,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575 4.2.1.17 ko:K01692,ko:K01715,ko:K07534 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko01220,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01200,map01212,map01220 M00032,M00087,M00540 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R05600,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02034,RC02115 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQ89@1239,4HBW0@91061,COG1024@1,COG1024@2 NA|NA|NA I Belongs to the enoyl-CoA hydratase isomerase family MAG.T1.121_01202 997346.HMPREF9374_3293 9.2e-51 207.2 Thermoactinomycetaceae 5.3.3.18 ko:K15866 ko00360,ko01120,map00360,map01120 R09837,R09839 RC00004,RC00326,RC02689,RC03003 ko00000,ko00001,ko01000 Bacteria 1TQ2V@1239,27B90@186824,4HBT0@91061,COG1024@1,COG1024@2 NA|NA|NA I Enoyl-CoA hydratase/isomerase MAG.T1.121_01203 1386089.N865_04310 1.7e-34 152.9 Intrasporangiaceae ppaX 3.1.3.105,3.1.3.18,3.6.1.1 ko:K01091,ko:K06019,ko:K16017,ko:K22292 ko00190,ko00520,ko00630,ko01051,ko01100,ko01110,ko01130,map00190,map00520,map00630,map01051,map01100,map01110,map01130 R01334,R06587,R11785 RC00017,RC00078 ko00000,ko00001,ko01000 Bacteria 2I9FC@201174,4FGUD@85021,COG0546@1,COG0546@2 NA|NA|NA S HAD family hydrolase MAG.T1.121_01204 479434.Sthe_0682 1.4e-17 96.3 Chloroflexi cspC ko:K03704 ko00000,ko03000 Bacteria 2G79W@200795,COG1278@1,COG1278@2 NA|NA|NA K Probable zinc-ribbon domain MAG.T1.121_01205 485913.Krac_2931 1.5e-58 233.0 Bacteria 1.1.1.203 ko:K18981 ko00053,map00053 R10841 RC00066 ko00000,ko00001,ko01000 Bacteria COG0451@1,COG0451@2 NA|NA|NA GM ADP-glyceromanno-heptose 6-epimerase activity MAG.T1.121_01206 1122132.AQYH01000007_gene2017 8.4e-171 607.1 Bacteria Bacteria 2EX2Q@1,33QDU@2 NA|NA|NA MAG.T1.121_01207 1052684.PPM_3517 4.4e-36 157.9 Paenibacillaceae ttr Bacteria 1V299@1239,26XKE@186822,4HG1C@91061,COG0454@1,COG0456@2 NA|NA|NA K GCN5 family acetyltransferase MAG.T1.121_01208 264732.Moth_1955 2.4e-140 505.4 Thermoanaerobacterales 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 Bacteria 1TP0J@1239,247NQ@186801,42EKB@68295,COG0436@1,COG0436@2 NA|NA|NA E PFAM aminotransferase, class I MAG.T1.121_01209 933115.GPDM_07490 6.2e-44 184.9 Planococcaceae rbsB GO:0003674,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006935,GO:0008150,GO:0008643,GO:0009605,GO:0015144,GO:0015145,GO:0015749,GO:0015750,GO:0015752,GO:0016020,GO:0016021,GO:0022857,GO:0030246,GO:0030288,GO:0030313,GO:0031224,GO:0031975,GO:0034219,GO:0036094,GO:0040011,GO:0042221,GO:0042330,GO:0042597,GO:0044425,GO:0044464,GO:0048029,GO:0050896,GO:0050918,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944 ko:K02058,ko:K10439 ko02010,ko02030,map02010,map02030 M00212,M00221 ko00000,ko00001,ko00002,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 Bacteria 1TQ1B@1239,26CZH@186818,4HCSN@91061,COG1879@1,COG1879@2 NA|NA|NA G Periplasmic binding protein domain MAG.T1.121_01210 926550.CLDAP_27320 4.1e-143 515.0 Chloroflexi rbsA 3.6.3.17 ko:K10441 ko02010,map02010 M00212 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 Bacteria 2G649@200795,COG1129@1,COG1129@2 NA|NA|NA P Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system MAG.T1.121_01211 926550.CLDAP_35310 2.6e-66 259.2 Chloroflexi ko:K10440,ko:K17209 ko02010,map02010 M00212,M00592 ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.21 Bacteria 2G6A4@200795,COG1172@1,COG1172@2 NA|NA|NA G Branched-chain amino acid transport system / permease component MAG.T1.121_01213 1382304.JNIL01000001_gene2462 3.5e-35 154.5 Bacilli 5.4.99.62 ko:K06726 ko02010,map02010 R08247 RC02247 ko00000,ko00001,ko01000 Bacteria 1VA2V@1239,4HIFW@91061,COG1869@1,COG1869@2 NA|NA|NA G Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose MAG.T1.121_01214 289377.HL41_03795 2.5e-12 78.2 Thermodesulfobacteria uxaA 4.2.1.7 ko:K01685,ko:K16849,ko:K16850 ko00040,ko01100,map00040,map01100 M00631 R01540 RC00543 ko00000,ko00001,ko00002,ko01000 Bacteria 2GI4H@200940,COG2721@1,COG2721@2 NA|NA|NA G SAF domain MAG.T1.121_01215 497964.CfE428DRAFT_2325 4.4e-81 308.5 Verrucomicrobia uxaA 4.2.1.7 ko:K01685 ko00040,ko01100,map00040,map01100 M00631 R01540 RC00543 ko00000,ko00001,ko00002,ko01000 Bacteria 46UHM@74201,COG2721@1,COG2721@2 NA|NA|NA G PFAM D-galactarate dehydratase Altronate hydrolase domain protein MAG.T1.121_01216 1536775.H70737_09845 1.9e-52 212.6 Paenibacillaceae Bacteria 1VW53@1239,26UT6@186822,4HWRP@91061,COG0684@1,COG0684@2 NA|NA|NA H Aldolase/RraA MAG.T1.121_01217 1131814.JAFO01000001_gene1423 9e-37 159.8 Xanthobacteraceae Bacteria 1RD1K@1224,2U6ZZ@28211,3F2BP@335928,COG2128@1,COG2128@2 NA|NA|NA S Carboxymuconolactone decarboxylase family MAG.T1.121_01218 448385.sce1313 2.2e-50 205.3 Myxococcales cah 4.2.1.1 ko:K01673 ko00910,map00910 R00132,R10092 RC02807 ko00000,ko00001,ko01000 Bacteria 1R3SC@1224,2WZ54@28221,2Z1CJ@29,434U6@68525,COG0288@1,COG0288@2 NA|NA|NA H Reversible hydration of carbon dioxide MAG.T1.121_01219 485913.Krac_9449 3.9e-157 561.6 Chloroflexi uxaA 4.2.1.7 ko:K01685,ko:K16849 ko00040,ko01100,map00040,map01100 M00631 R01540 RC00543 ko00000,ko00001,ko00002,ko01000 Bacteria 2G8E3@200795,COG2721@1,COG2721@2 NA|NA|NA G D-galactarate dehydratase / Altronate hydrolase, C terminus MAG.T1.121_01220 485913.Krac_9338 1e-17 97.1 Chloroflexi ko:K00782 ko00000 Bacteria 2G7BK@200795,COG1556@1,COG1556@2 NA|NA|NA S LUD domain MAG.T1.121_01221 485913.Krac_9337 1.7e-203 716.1 Chloroflexi lutB ko:K00782,ko:K18929 ko00000 Bacteria 2G665@200795,COG0247@1,COG0247@2,COG1139@1,COG1139@2 NA|NA|NA C Iron-sulfur cluster binding protein MAG.T1.121_01222 471853.Bcav_0314 6.3e-69 267.7 Actinobacteria MA20_14845 4.2.1.141 ko:K14259 ko00040,map00040 R09186 RC00429 ko00000,ko00001,ko01000 Bacteria 2GN7V@201174,COG3970@1,COG3970@2 NA|NA|NA S fumarylacetoacetate (FAA) hydrolase MAG.T1.121_01224 469383.Cwoe_0493 1e-39 171.0 Bacteria 2.1.1.303 ko:K20421 ko01059,ko01130,map01059,map01130 M00830 R10963 RC00003,RC00392 ko00000,ko00001,ko00002,ko01000 Bacteria COG2890@1,COG2890@2 NA|NA|NA J protein-(glutamine-N5) methyltransferase activity MAG.T1.121_01225 1394178.AWOO02000029_gene4640 1.6e-87 329.7 Streptosporangiales ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 2H4BW@201174,4EGK6@85012,COG4608@1,COG4608@2 NA|NA|NA E Oligopeptide/dipeptide transporter, C-terminal region MAG.T1.121_01226 644966.Tmar_1797 5.1e-86 324.7 Clostridiales incertae sedis oppD ko:K02031,ko:K02032,ko:K15583 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 1TP6E@1239,247NN@186801,3WCYH@538999,COG0444@1,COG0444@2 NA|NA|NA EP Belongs to the ABC transporter superfamily MAG.T1.121_01227 1123237.Salmuc_00833 8.6e-64 250.8 Alphaproteobacteria ko:K02034 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 1R43W@1224,2U1PI@28211,COG1173@1,COG1173@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component MAG.T1.121_01228 469383.Cwoe_5014 5.3e-98 364.4 Actinobacteria ko:K02033 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 2GK0Z@201174,COG0601@1,COG0601@2 NA|NA|NA EP PFAM binding-protein-dependent transport systems inner membrane component MAG.T1.121_01229 469383.Cwoe_0494 1.6e-110 406.8 Actinobacteria ko:K02035 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 2GM5G@201174,COG0747@1,COG0747@2 NA|NA|NA E ABC transporter substrate-binding protein MAG.T1.121_01230 649639.Bcell_1032 6.1e-38 165.2 Bacillus xylR Bacteria 1TQCE@1239,1ZC4Y@1386,4HDE3@91061,COG1940@1,COG1940@2 NA|NA|NA GK ROK family MAG.T1.121_01231 1033743.CAES01000001_gene1711 1.7e-59 236.1 Paenibacillaceae Bacteria 1TUFR@1239,26YXG@186822,4I855@91061,COG2120@1,COG2120@2 NA|NA|NA S GlcNAc-PI de-N-acetylase MAG.T1.121_01232 550540.Fbal_0374 7e-52 210.7 Gammaproteobacteria yniC GO:0000287,GO:0003674,GO:0003824,GO:0003850,GO:0004346,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0050084,GO:0050286,GO:0050308,GO:0050309 3.1.3.23 ko:K19270 ko00000,ko01000 Bacteria 1NF90@1224,1RNP8@1236,COG0637@1,COG0637@2 NA|NA|NA S HAD-superfamily hydrolase subfamily IA, variant 3 MAG.T1.121_01233 1223542.GM1_041_00210 5.8e-19 101.7 Gordoniaceae kcsA ko:K10716 ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 Bacteria 2GKNF@201174,4GEKX@85026,COG1226@1,COG1226@2 NA|NA|NA P Ion transport protein MAG.T1.121_01234 479434.Sthe_2906 1.1e-201 709.5 Thermomicrobia aceB GO:0003674,GO:0003824,GO:0004474,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006081,GO:0006082,GO:0006097,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044424,GO:0044464,GO:0046487,GO:0046912,GO:0071704 2.3.3.9 ko:K01638 ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200 M00012 R00472 RC00004,RC00308,RC02747 ko00000,ko00001,ko00002,ko01000 iEC55989_1330.EC55989_4499,iLF82_1304.LF82_0013,iNRG857_1313.NRG857_20010 Bacteria 27Y0V@189775,2G63R@200795,COG2225@1,COG2225@2 NA|NA|NA C Malate synthase MAG.T1.121_01236 1121090.KB894722_gene3200 9.1e-22 112.1 Bacillus ydbT ko:K08981 ko00000 Bacteria 1TSRJ@1239,1ZBIF@1386,4HB8P@91061,COG3428@1,COG3428@2 NA|NA|NA S Membrane MAG.T1.121_01237 35754.JNYJ01000001_gene7463 1.4e-08 66.6 Micromonosporales Bacteria 2EAFX@1,2IJ6Y@201174,32G8D@2,4DDN7@85008 NA|NA|NA MAG.T1.121_01238 32057.KB217478_gene615 8.4e-76 291.6 Nostocales 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 Bacteria 1G1H1@1117,1HSHH@1161,COG0154@1,COG0154@2 NA|NA|NA J Amidase MAG.T1.121_01239 316274.Haur_2917 4.7e-94 351.7 Chloroflexi Bacteria 2G8D3@200795,COG4805@1,COG4805@2 NA|NA|NA S Protein conserved in bacteria MAG.T1.121_01241 266117.Rxyl_2946 1.3e-92 347.8 Rubrobacteria Bacteria 2GIZ1@201174,4CPZ0@84995,COG2197@1,COG2197@2,COG3903@1,COG3903@2 NA|NA|NA T Transcriptional regulator MAG.T1.121_01242 1299327.I546_6182 4e-14 84.0 Mycobacteriaceae Bacteria 23BKG@1762,2DSMH@1,2GR8G@201174,33GPM@2 NA|NA|NA MAG.T1.121_01243 1299327.I546_6183 9.2e-45 186.4 Mycobacteriaceae GO:0005575,GO:0005576 ko:K07064 ko00000 Bacteria 239HU@1762,2IJ89@201174,COG1848@1,COG1848@2 NA|NA|NA S Toxic component of a toxin-antitoxin (TA) module. An RNase MAG.T1.121_01244 479434.Sthe_2416 1.4e-192 679.1 Thermomicrobia glnA2 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0044464,GO:0050001,GO:0071944 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 Bacteria 27XSZ@189775,2G5U2@200795,COG0174@1,COG0174@2 NA|NA|NA E glutamine synthetase MAG.T1.121_01245 251221.35211615 1e-177 629.8 Cyanobacteria glnA 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 Bacteria 1G255@1117,COG0174@1,COG0174@2 NA|NA|NA E glutamine synthetase MAG.T1.121_01246 751944.HALDL1_04220 2e-38 166.0 Halobacteria Archaea 23URV@183963,2XVN3@28890,arCOG08948@1,arCOG08948@2157 NA|NA|NA S Ferritin-like domain MAG.T1.121_01247 756883.Halar_2275 2e-33 149.1 Archaea Archaea arCOG08948@1,arCOG08948@2157 NA|NA|NA S Ferritin-like domain MAG.T1.121_01249 266117.Rxyl_2325 5.3e-118 431.0 Rubrobacteria pdhA 1.2.4.1 ko:K00161 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2IBRC@201174,4CS4C@84995,COG1071@1,COG1071@2 NA|NA|NA C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) MAG.T1.121_01250 266117.Rxyl_2324 1.1e-141 509.6 Rubrobacteria pdhB 1.2.4.1 ko:K00162,ko:K21417 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2753 Bacteria 2GKFE@201174,4CRUB@84995,COG0022@1,COG0022@2 NA|NA|NA C Transketolase, pyrimidine binding domain MAG.T1.121_01251 479434.Sthe_1933 1.7e-105 389.8 Thermomicrobia pdhC 1.2.4.1,2.3.1.12 ko:K00162,ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R02569,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02857,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 27Y2C@189775,2G619@200795,COG0508@1,COG0508@2 NA|NA|NA C 2-oxoacid dehydrogenases acyltransferase (catalytic domain) MAG.T1.121_01252 326427.Cagg_2447 2.8e-134 485.7 Chloroflexia rnj ko:K12574 ko03018,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 2G611@200795,374ZT@32061,COG0595@1,COG0595@2 NA|NA|NA S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay MAG.T1.121_01253 479434.Sthe_0942 2.7e-66 258.5 Thermomicrobia 3.2.2.27 ko:K21929 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 27XM8@189775,2G6BR@200795,COG1573@1,COG1573@2 NA|NA|NA L Uracil DNA glycosylase superfamily MAG.T1.121_01254 479434.Sthe_0940 8.8e-146 524.2 Thermomicrobia cho GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006289,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009380,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016787,GO:0016788,GO:0030312,GO:0031668,GO:0032991,GO:0033554,GO:0033683,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1902494,GO:1905347,GO:1905348,GO:1990391 2.7.7.7 ko:K02342,ko:K03703,ko:K05984 ko00230,ko00240,ko01100,ko03030,ko03420,ko03430,ko03440,map00230,map00240,map01100,map03030,map03420,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 27XSW@189775,2G7WZ@200795,COG0322@1,COG0322@2,COG0847@1,COG0847@2 NA|NA|NA L GIY-YIG type nucleases (URI domain) MAG.T1.121_01255 479434.Sthe_0939 1.2e-219 769.6 Thermomicrobia ligA GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0034645,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050662,GO:0050896,GO:0051103,GO:0051287,GO:0051716,GO:0070403,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1901576 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 iEC55989_1330.EC55989_2701,iECABU_c1320.ECABU_c27320,iECIAI1_1343.ECIAI1_2469,iECO103_1326.ECO103_2930,iECO111_1330.ECO111_3141,iECO26_1355.ECO26_3464,iECSE_1348.ECSE_2702,iECW_1372.ECW_m2640,iEKO11_1354.EKO11_1317,iEcE24377_1341.EcE24377A_2698,iEcSMS35_1347.EcSMS35_2566,iWFL_1372.ECW_m2640,iYL1228.KPN_02758,ic_1306.c2945 Bacteria 27XIY@189775,2G5TK@200795,COG0272@1,COG0272@2 NA|NA|NA L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA MAG.T1.121_01257 479434.Sthe_0937 8.9e-59 233.4 Thermomicrobia pyrE 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 Bacteria 27YBT@189775,2G6RG@200795,COG0461@1,COG0461@2 NA|NA|NA F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) MAG.T1.121_01258 525904.Tter_1369 1.6e-90 339.7 unclassified Bacteria cax GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015085,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015368,GO:0015369,GO:0015491,GO:0015672,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051139,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:0099516,GO:1902600 ko:K07300 ko00000,ko02000 2.A.19 iJN678.slr1336 Bacteria 2NQA1@2323,COG0387@1,COG0387@2 NA|NA|NA P Sodium/calcium exchanger protein MAG.T1.121_01259 479434.Sthe_0936 0.0 1564.3 Thermomicrobia carB 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 Bacteria 27XRT@189775,2G5NX@200795,COG0458@1,COG0458@2 NA|NA|NA F Carbamoyl-phosphate synthetase large chain, oligomerisation domain MAG.T1.121_01260 479434.Sthe_0935 4.5e-123 448.0 Thermomicrobia carA GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01955,ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1383 Bacteria 27XJV@189775,2G5S1@200795,COG0505@1,COG0505@2 NA|NA|NA F Carbamoyl-phosphate synthase small chain, CPSase domain MAG.T1.121_01261 309801.trd_0214 8.8e-118 430.6 Thermomicrobia pyrC GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 Bacteria 27XK1@189775,2G640@200795,COG0044@1,COG0044@2 NA|NA|NA F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily MAG.T1.121_01262 479434.Sthe_1073 5e-51 208.0 Chloroflexi nth 4.2.99.18 ko:K10773 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 2G6QA@200795,COG0177@1,COG0177@2 NA|NA|NA L FES MAG.T1.121_01263 1382356.JQMP01000003_gene2296 3.6e-29 135.2 Thermomicrobia Bacteria 27Z7X@189775,2G726@200795,COG0406@1,COG0406@2 NA|NA|NA G Phosphoglycerate mutase family MAG.T1.121_01264 1382356.JQMP01000003_gene2295 3e-54 218.8 Thermomicrobia yhfI GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267 Bacteria 27YCM@189775,2GBGY@200795,COG1234@1,COG1234@2 NA|NA|NA S Metallo-beta-lactamase superfamily MAG.T1.121_01265 1382356.JQMP01000003_gene2294 2e-51 209.5 Thermomicrobia Bacteria 27Y1T@189775,2G6BG@200795,COG3191@1,COG3191@2 NA|NA|NA EQ Peptidase family S58 MAG.T1.121_01267 479434.Sthe_1068 1.9e-39 168.7 Thermomicrobia rpsI GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02996 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 27YEC@189775,2G6UZ@200795,COG0103@1,COG0103@2 NA|NA|NA J Belongs to the universal ribosomal protein uS9 family MAG.T1.121_01268 1177181.T9A_02044 1.2e-45 189.5 Oceanospirillales rplM GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0070180,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 ko:K02871 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1RA11@1224,1S280@1236,1XJIQ@135619,COG0102@1,COG0102@2 NA|NA|NA J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly MAG.T1.121_01269 479434.Sthe_1066 6.8e-52 211.1 Thermomicrobia truA GO:0000049,GO:0001522,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0030312,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363 5.4.99.12 ko:K06173 ko00000,ko01000,ko03016 Bacteria 27YAN@189775,2G6PE@200795,COG0101@1,COG0101@2 NA|NA|NA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs MAG.T1.121_01270 1382356.JQMP01000003_gene2289 3e-33 147.9 Thermomicrobia rplQ GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02879,ko:K16193 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 27YDE@189775,2G79I@200795,COG0203@1,COG0203@2 NA|NA|NA J Ribosomal protein L17 MAG.T1.121_01271 479434.Sthe_1064 2e-101 375.9 Thermomicrobia rpoA GO:0003674,GO:0003824,GO:0003899,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 Bacteria 27XMD@189775,2G5M9@200795,COG0202@1,COG0202@2 NA|NA|NA K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates MAG.T1.121_01272 479434.Sthe_1063 1.2e-85 322.8 Thermomicrobia rpsD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0016020,GO:0019222,GO:0019843,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 ko:K02986 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 27XMY@189775,2G6AZ@200795,COG0522@1,COG0522@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit MAG.T1.121_01273 1382356.JQMP01000003_gene2286 3.2e-55 221.1 Thermomicrobia rpsK GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02948 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 27YAA@189775,2G6HG@200795,COG0100@1,COG0100@2 NA|NA|NA J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome MAG.T1.121_01274 479434.Sthe_1061 4e-49 200.7 Thermomicrobia rpsM GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02952 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 27YAQ@189775,2G6PF@200795,COG0099@1,COG0099@2 NA|NA|NA J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits MAG.T1.121_01275 439292.Bsel_0136 9.4e-75 287.0 Sporolactobacillaceae map 3.4.11.18 ko:K01265 ko00000,ko01000,ko01002 Bacteria 1TQC1@1239,26NAM@186821,4H9S9@91061,COG0024@1,COG0024@2 NA|NA|NA J Metallopeptidase family M24 MAG.T1.121_01276 479434.Sthe_1057 4e-55 221.5 Thermomicrobia adk 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 27XR9@189775,2G6GP@200795,COG0563@1,COG0563@2 NA|NA|NA F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism MAG.T1.121_01277 479434.Sthe_1056 3.1e-168 598.2 Thermomicrobia secY GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5 Bacteria 27XI1@189775,2G5X4@200795,COG0201@1,COG0201@2 NA|NA|NA U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently MAG.T1.121_01278 479434.Sthe_1055 1.4e-35 156.4 Thermomicrobia rplO GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02876 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 27YEH@189775,2G6T9@200795,COG0200@1,COG0200@2 NA|NA|NA J Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A MAG.T1.121_01279 666686.B1NLA3E_00630 1.1e-11 75.5 Bacillus rpmD GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02907 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1VEG4@1239,1ZITD@1386,4HNHF@91061,COG1841@1,COG1841@2 NA|NA|NA J Ribosomal protein L30 MAG.T1.121_01280 1121422.AUMW01000023_gene2770 7.3e-50 203.8 Peptococcaceae rpsE GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990145,GO:1990904 ko:K02988 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V1B1@1239,24G5D@186801,261HV@186807,COG0098@1,COG0098@2 NA|NA|NA J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body MAG.T1.121_01281 479434.Sthe_1052 1.2e-32 146.0 Thermomicrobia rplR GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02881 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 27YG4@189775,2G6Y4@200795,COG0256@1,COG0256@2 NA|NA|NA J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance MAG.T1.121_01282 479434.Sthe_1051 7e-58 230.3 Thermomicrobia rplF GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02933 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 27Y65@189775,2G6HZ@200795,COG0097@1,COG0097@2 NA|NA|NA J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center MAG.T1.121_01283 479434.Sthe_1050 6.3e-48 196.8 Thermomicrobia rpsH GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 ko:K02994 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 27YFX@189775,2G6XS@200795,COG0096@1,COG0096@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit MAG.T1.121_01284 479434.Sthe_1049 2.5e-20 104.0 Chloroflexi rpsN GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02954 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2G74J@200795,COG0199@1,COG0199@2 NA|NA|NA J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site MAG.T1.121_01285 279010.BL01039 1.9e-71 275.4 Bacillus rplE GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02931 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1TPE0@1239,1ZB6T@1386,4HBAX@91061,COG0094@1,COG0094@2 NA|NA|NA J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits MAG.T1.121_01286 309801.trd_0973 1.5e-23 115.5 Thermomicrobia rplX GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02895 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 27YGR@189775,2G750@200795,COG0198@1,COG0198@2 NA|NA|NA J Ribosomal proteins 50S L24/mitochondrial 39S L24 MAG.T1.121_01287 479434.Sthe_1046 2.1e-50 204.9 Thermomicrobia rplN GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02874 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 27YG0@189775,2G6MZ@200795,COG0093@1,COG0093@2 NA|NA|NA J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome MAG.T1.121_01288 479434.Sthe_1045 1.5e-27 128.6 Thermomicrobia rpsQ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02961 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 27YK1@189775,2G722@200795,COG0186@1,COG0186@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA MAG.T1.121_01289 479434.Sthe_1044 1e-09 68.9 Thermomicrobia rpmC GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02904 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 27YQH@189775,2GAWF@200795,COG0255@1,COG0255@2 NA|NA|NA J Belongs to the universal ribosomal protein uL29 family MAG.T1.121_01290 316274.Haur_4922 2.5e-53 214.9 Chloroflexia rplP GO:0000027,GO:0000049,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02878 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2G6NA@200795,375KU@32061,COG0197@1,COG0197@2 NA|NA|NA J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs MAG.T1.121_01291 479434.Sthe_1042 4.3e-81 307.8 Thermomicrobia rpsC GO:0000028,GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02982 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 27XP0@189775,2G691@200795,COG0092@1,COG0092@2 NA|NA|NA J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation MAG.T1.121_01292 479434.Sthe_1041 3.6e-28 131.0 Thermomicrobia rplV GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042788,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02890 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 27YKE@189775,2G6ZQ@200795,COG0091@1,COG0091@2 NA|NA|NA J Ribosomal protein L22p/L17e MAG.T1.121_01293 1382356.JQMP01000003_gene2265 6.1e-35 153.3 Thermomicrobia rpsS GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02965 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 27YG8@189775,2G6US@200795,COG0185@1,COG0185@2 NA|NA|NA J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA MAG.T1.121_01294 485913.Krac_12525 6.2e-114 417.2 Chloroflexi rplB GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02886 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2G65E@200795,COG0090@1,COG0090@2 NA|NA|NA J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity MAG.T1.121_01295 309801.trd_0982 3.2e-23 114.4 Thermomicrobia rplW GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02892 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 27YJ6@189775,2G73T@200795,COG0089@1,COG0089@2 NA|NA|NA J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome MAG.T1.121_01296 1382356.JQMP01000003_gene2262 2.6e-65 255.4 Thermomicrobia rplD GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003700,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0005886,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008428,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030234,GO:0030312,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032069,GO:0032074,GO:0032268,GO:0032269,GO:0032991,GO:0032993,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042788,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060698,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0065003,GO:0065007,GO:0065009,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:0098772,GO:0140110,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990904,GO:2000112,GO:2000113,GO:2001141 ko:K02926,ko:K16193 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 27XF6@189775,2G6K2@200795,COG0088@1,COG0088@2 NA|NA|NA J Forms part of the polypeptide exit tunnel MAG.T1.121_01299 1038858.AXBA01000015_gene2058 2e-34 152.9 Xanthobacteraceae ko:K06996 ko00000 Bacteria 1R81W@1224,2U6BE@28211,3F2BG@335928,COG3324@1,COG3324@2 NA|NA|NA S Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily MAG.T1.121_01300 861299.J421_1250 6.2e-31 141.4 Gemmatimonadetes ko:K06996 ko00000 Bacteria 1ZU3H@142182,COG3324@1,COG3324@2 NA|NA|NA E translation initiation factor activity MAG.T1.121_01301 1122138.AQUZ01000016_gene220 2.3e-32 145.2 Propionibacteriales Bacteria 2GSTR@201174,4DV3T@85009,COG3871@1,COG3871@2 NA|NA|NA S Pfam:Pyridox_oxidase MAG.T1.121_01302 1449353.JQMQ01000005_gene2985 3.7e-09 69.3 Streptacidiphilus Bacteria 2GJ55@201174,2NG1T@228398,COG2214@1,COG2214@2 NA|NA|NA O Heat shock protein DnaJ domain protein MAG.T1.121_01303 457429.ABJI02000746_gene5299 1.4e-105 389.8 Actinobacteria mro 5.1.3.3 ko:K01785 ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130 M00632 R01602,R10619 RC00563 ko00000,ko00001,ko00002,ko01000 Bacteria 2GME9@201174,COG2017@1,COG2017@2 NA|NA|NA G Converts alpha-aldose to the beta-anomer MAG.T1.121_01304 272560.BPSS2072 2e-153 548.9 Burkholderiaceae dgoD Bacteria 1K03P@119060,1MURK@1224,2VPUK@28216,COG4948@1,COG4948@2 NA|NA|NA M mandelate racemase muconate lactonizing MAG.T1.121_01305 1382356.JQMP01000003_gene1536 2.7e-136 492.3 Thermomicrobia dnaA GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006172,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009133,GO:0009135,GO:0009136,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009179,GO:0009180,GO:0009185,GO:0009188,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016311,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046031,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990837 ko:K02313 ko02020,ko04112,map02020,map04112 ko00000,ko00001,ko03032,ko03036 Bacteria 27XP6@189775,2G5W8@200795,COG0593@1,COG0593@2 NA|NA|NA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids MAG.T1.121_01306 479434.Sthe_1360 1.2e-49 203.4 Thermomicrobia Bacteria 27YB6@189775,2G789@200795,COG2452@1,COG2452@2 NA|NA|NA L Helix-turn-helix domain MAG.T1.121_01309 1449976.KALB_6950 2.8e-26 125.2 Pseudonocardiales Bacteria 2IFC3@201174,4E5F3@85010,COG3871@1,COG3871@2 NA|NA|NA S stress protein (general stress protein 26) MAG.T1.121_01310 1196028.ALEF01000033_gene1408 3.7e-27 128.6 Virgibacillus XK27_07850 Bacteria 1VBH9@1239,4C67H@84406,4HIBM@91061,COG0517@1,COG0517@2 NA|NA|NA S Domain in cystathionine beta-synthase and other proteins. MAG.T1.121_01311 479434.Sthe_2353 5.2e-33 147.9 Chloroflexi adsA ko:K03088 ko00000,ko03021 Bacteria 2G6X7@200795,COG1595@1,COG1595@2 NA|NA|NA K TIGRFAM RNA polymerase sigma factor, sigma-70 family MAG.T1.121_01312 1449044.JMLE01000026_gene1537 4.8e-10 72.4 Actinobacteria Bacteria 2B2T8@1,2GVG1@201174,31VDK@2 NA|NA|NA MAG.T1.121_01313 1384057.CD33_07630 5.1e-24 117.9 Lysinibacillus sodC GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005576,GO:0005615,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008270,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044421,GO:0046872,GO:0046914,GO:0046983,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748 1.15.1.1 ko:K04565 ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020 ko00000,ko00001,ko01000 Bacteria 1V3HM@1239,3J04V@400634,4HHM6@91061,COG2032@1,COG2032@2 NA|NA|NA P Superoxide dismutase MAG.T1.121_01314 1283287.KB822582_gene2945 6.8e-15 87.4 Actinobacteria Bacteria 2I7QR@201174,COG4803@1,COG4803@2 NA|NA|NA S Protein of unknown function (DUF1269) MAG.T1.121_01315 1173024.KI912152_gene385 3.7e-24 119.0 Cyanobacteria Bacteria 1GB61@1117,COG4803@1,COG4803@2 NA|NA|NA S membrane protein of uknown function UCP014873 MAG.T1.121_01316 1123023.JIAI01000016_gene3410 1.9e-98 365.9 Pseudonocardiales pip 3.4.11.5 ko:K01259 ko00330,map00330 R00135 ko00000,ko00001,ko01000,ko01002 Bacteria 2H83P@201174,4DYV8@85010,COG2267@1,COG2267@2 NA|NA|NA E Belongs to the peptidase S33 family MAG.T1.121_01317 1382304.JNIL01000001_gene1208 6.4e-190 670.6 Bacilli ilvD4 4.2.1.82,4.2.1.9 ko:K01687,ko:K22186 ko00040,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00040,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R02429,R04441,R05070 RC00468,RC00543,RC01714 ko00000,ko00001,ko00002,ko01000 Bacteria 1VRUT@1239,4HDEU@91061,COG0129@1,COG0129@2 NA|NA|NA EG Catalyzes the formation of 3-methyl-2-oxobutanoate from 2,3,-dihydroxy-3-methylbutanoate MAG.T1.121_01318 768710.DesyoDRAFT_3228 1.1e-28 132.9 Peptococcaceae cspC ko:K03704 ko00000,ko03000 Bacteria 1VBBH@1239,24QK9@186801,265AD@186807,COG1278@1,COG1278@2 NA|NA|NA K Probable zinc-ribbon domain MAG.T1.121_01319 479434.Sthe_1088 4.2e-25 120.6 Chloroflexi infA GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009986,GO:0030246,GO:0030247,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:2001065 ko:K02518 ko00000,ko03012 Bacteria 2G7AQ@200795,COG0361@1,COG0361@2 NA|NA|NA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex MAG.T1.121_01320 1176165.CAJD01000011_gene451 7.6e-33 147.5 Brevibacteriaceae glxR GO:0000166,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010675,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030312,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0032993,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000874,GO:2001141 ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 ko00000,ko00001,ko03000 Bacteria 2GMPN@201174,4F906@85019,COG0664@1,COG0664@2 NA|NA|NA K Cyclic nucleotide-monophosphate binding domain MAG.T1.121_01321 525904.Tter_1090 3e-20 104.8 unclassified Bacteria yvlD ko:K08972 ko00000 Bacteria 2NQ43@2323,COG1950@1,COG1950@2 NA|NA|NA S Mycobacterial 4 TMS phage holin, superfamily IV MAG.T1.121_01323 1144312.PMI09_05436 1.8e-12 79.3 Rhizobiaceae Bacteria 1RAJ2@1224,2U6M7@28211,4BBUE@82115,COG4803@1,COG4803@2 NA|NA|NA S Protein of unknown function (DUF1269) MAG.T1.121_01324 313612.L8106_13140 1.1e-59 236.9 Oscillatoriales Bacteria 1G1SP@1117,1H91U@1150,COG0500@1,COG2226@2 NA|NA|NA Q O-methyltransferase MAG.T1.121_01325 1211814.CAPG01000027_gene1192 4.8e-87 329.3 Bacillus acyII 3.5.1.11,3.5.1.97 ko:K01434,ko:K07116 ko00311,ko01130,map00311,map01130 R02170 RC00166,RC00328 ko00000,ko00001,ko01000,ko01002 Bacteria 1UFHA@1239,1ZCMT@1386,4HACM@91061,COG2366@1,COG2366@2 NA|NA|NA S Penicillin amidase MAG.T1.121_01331 1382356.JQMP01000004_gene530 1.9e-67 263.1 Thermomicrobia mprF ko:K07027 ko00000,ko02000 4.D.2 Bacteria 27Y04@189775,2G5KF@200795,COG0392@1,COG0392@2 NA|NA|NA S Lysylphosphatidylglycerol synthase TM region MAG.T1.121_01332 479434.Sthe_2017 1e-66 260.4 Thermomicrobia uppP GO:0006950,GO:0008150,GO:0050896,GO:0051409 3.6.1.27 ko:K06153 ko00550,map00550 R05627 RC00002 ko00000,ko00001,ko01000,ko01011 Bacteria 27Y0J@189775,2G6F7@200795,COG1968@1,COG1968@2 NA|NA|NA V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin MAG.T1.121_01333 290317.Cpha266_0758 8.6e-23 113.2 Chlorobi ko:K21903 ko00000,ko03000 Bacteria 1FFAY@1090,COG0640@1,COG0640@2 NA|NA|NA K PFAM regulatory protein, ArsR MAG.T1.121_01334 696369.KI912183_gene1805 1.5e-138 500.4 Peptococcaceae cadA 3.6.3.3,3.6.3.5 ko:K01534 ko00000,ko01000 3.A.3.6 Bacteria 1TQ07@1239,248EH@186801,260Y1@186807,COG2217@1,COG2217@2 NA|NA|NA P ATPase, P-type (transporting), HAD superfamily, subfamily IC MAG.T1.121_01335 479434.Sthe_3008 3.9e-81 309.7 Thermomicrobia ycnJ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K07156,ko:K07245,ko:K14166 ko00000,ko02000 9.B.62.1,9.B.62.2 Bacteria 27XZB@189775,2G8KM@200795,COG1276@1,COG1276@2,COG2372@1,COG2372@2 NA|NA|NA P Copper resistance protein CopC MAG.T1.121_01336 1382356.JQMP01000003_gene1510 4e-144 518.5 Thermomicrobia MA20_09815 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006508,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0019538,GO:0019752,GO:0030288,GO:0030313,GO:0031975,GO:0034722,GO:0036374,GO:0042597,GO:0043094,GO:0043102,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070011,GO:0071704,GO:0097264,GO:0140096,GO:1901564,GO:1901566,GO:1901576 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 Bacteria 27XH8@189775,2GABC@200795,COG0405@1,COG0405@2 NA|NA|NA E TIGRFAM gamma-glutamyltransferase MAG.T1.121_01337 867903.ThesuDRAFT_02358 3.6e-57 228.8 Clostridiales incertae sedis splB Bacteria 1TSS2@1239,248SB@186801,3WDHP@538999,COG1533@1,COG1533@2 NA|NA|NA L Elongator protein 3, MiaB family, Radical SAM MAG.T1.121_01339 509191.AEDB02000094_gene4331 7.6e-43 180.3 Bacteria ntd 2.4.2.6 ko:K08728 ko00240,map00240 R02806 RC00063 ko00000,ko00001,ko01000 Bacteria COG3613@1,COG3613@2 NA|NA|NA F nucleoside 2-deoxyribosyltransferase MAG.T1.121_01340 479434.Sthe_1388 2.9e-64 251.9 Thermomicrobia ko:K06973 ko00000 Bacteria 27YW2@189775,2G6KQ@200795,COG2738@1,COG2738@2 NA|NA|NA S Putative neutral zinc metallopeptidase MAG.T1.121_01341 118161.KB235922_gene3107 2.8e-47 195.3 Pleurocapsales Bacteria 1G48N@1117,3VN0J@52604,COG4977@1,COG4977@2 NA|NA|NA K DJ-1/PfpI family MAG.T1.121_01342 485913.Krac_3672 9.7e-42 177.2 Chloroflexi yobR GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031248,GO:0031365,GO:0032991,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564,GO:1902493,GO:1902494,GO:1990234 2.3.1.1 ko:K22476 ko00220,ko01210,ko01230,map00220,map01210,map01230 R00259 RC00004,RC00064 ko00000,ko00001,ko01000 Bacteria 2G91C@200795,COG0454@1,COG0456@2 NA|NA|NA K Acetyltransferase (GNAT) domain MAG.T1.121_01343 1041930.Mtc_2229 5e-14 85.1 Methanomicrobia Archaea 2NA48@224756,2Y1E8@28890,arCOG01637@1,arCOG01637@2157 NA|NA|NA Q Methyltransferase domain MAG.T1.121_01344 266117.Rxyl_1091 1.3e-63 250.4 Rubrobacteria metXA 1.1.1.3,2.7.2.4 ko:K00003,ko:K12524 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00017,M00018,M00526,M00527 R00480,R01773,R01775 RC00002,RC00043,RC00087 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIX9@201174,4CPTX@84995,COG0460@1,COG0460@2 NA|NA|NA E Homoserine dehydrogenase MAG.T1.121_01345 1382356.JQMP01000003_gene2604 3.8e-93 349.4 Thermomicrobia accD GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009059,GO:0009273,GO:0009987,GO:0016020,GO:0016053,GO:0019752,GO:0032787,GO:0034645,GO:0042546,GO:0043170,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070589,GO:0071554,GO:0071704,GO:0071766,GO:0071767,GO:0071768,GO:0071840,GO:0071944,GO:0072330,GO:1901576 2.1.3.15,6.4.1.2 ko:K01962,ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 Bacteria 27XKR@189775,2G7S3@200795,COG0777@1,COG0777@2,COG0825@1,COG0825@2 NA|NA|NA I catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the MAG.T1.121_01346 479433.Caci_0840 3.7e-93 348.6 Actinobacteria purK GO:0000166,GO:0003674,GO:0003824,GO:0004638,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016829,GO:0016830,GO:0016831,GO:0016874,GO:0016879,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034028,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.4.18 ko:K01589 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07404 RC01927 ko00000,ko00001,ko00002,ko01000 iECUMN_1333.ECUMN_0562,iYL1228.KPN_00477 Bacteria 2GJCU@201174,COG0026@1,COG0026@2 NA|NA|NA F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) MAG.T1.121_01347 1169152.AXVD01000006_gene3365 4.3e-54 217.6 Nocardiaceae purE GO:0008150,GO:0040007 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 iJN678.purE,iNJ661.Rv3275c Bacteria 2IFFD@201174,4FUQW@85025,COG0041@1,COG0041@2 NA|NA|NA F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) MAG.T1.121_01348 479434.Sthe_1429 1.2e-230 805.8 Thermomicrobia pyrG GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1276,iECO103_1326.ECO103_3323,iHN637.CLJU_RS01075,iNJ661.Rv1699,iPC815.YPO3377 Bacteria 27XSS@189775,2G5U0@200795,COG0504@1,COG0504@2 NA|NA|NA F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates MAG.T1.121_01350 1382356.JQMP01000004_gene258 2.4e-49 202.2 Thermomicrobia Bacteria 27Y80@189775,2G6IQ@200795,COG2220@1,COG2220@2 NA|NA|NA S Beta-lactamase superfamily domain MAG.T1.121_01351 479434.Sthe_1432 2.7e-36 159.1 Thermomicrobia recX GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0019899,GO:0031668,GO:0033554,GO:0043086,GO:0044092,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496 2.4.1.337 ko:K03565,ko:K19002 ko00561,ko01100,map00561,map01100 R10850 RC00005,RC00059 ko00000,ko00001,ko01000,ko01003,ko03400 GT4 Bacteria 27YM4@189775,2G6WA@200795,COG2137@1,COG2137@2 NA|NA|NA S RecX family MAG.T1.121_01352 886293.Sinac_6412 1.4e-52 213.8 Planctomycetes csd Bacteria 2IXCD@203682,COG0520@1,COG0520@2 NA|NA|NA E selenocysteine lyase MAG.T1.121_01353 671143.DAMO_2646 3.8e-14 85.1 unclassified Bacteria pyrE 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 Bacteria 2NPFJ@2323,COG0461@1,COG0461@2 NA|NA|NA F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) MAG.T1.121_01354 1382356.JQMP01000004_gene220 5e-70 271.6 Thermomicrobia idsA 2.5.1.1,2.5.1.10,2.5.1.29 ko:K13787,ko:K13789 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00365,M00366 R01658,R02003,R02061 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 Bacteria 27XX1@189775,2G6BM@200795,COG0142@1,COG0142@2 NA|NA|NA H Belongs to the FPP GGPP synthase family MAG.T1.121_01355 479434.Sthe_1388 6.5e-61 240.7 Thermomicrobia ko:K06973 ko00000 Bacteria 27YW2@189775,2G6KQ@200795,COG2738@1,COG2738@2 NA|NA|NA S Putative neutral zinc metallopeptidase MAG.T1.121_01356 1380355.JNIJ01000005_gene2650 2.3e-14 85.1 Bradyrhizobiaceae Bacteria 1RICR@1224,2U9S9@28211,3JZPA@41294,COG0662@1,COG0662@2 NA|NA|NA G Cupin domain MAG.T1.121_01357 479434.Sthe_2100 2.2e-40 173.7 Thermomicrobia Bacteria 27XUR@189775,2G8JH@200795,COG1376@1,COG1376@2 NA|NA|NA S PFAM ErfK YbiS YcfS YnhG family protein MAG.T1.121_01362 856793.MICA_1243 1.2e-29 136.7 unclassified Alphaproteobacteria Bacteria 1RE42@1224,2CCI4@1,2UZGM@28211,30BPJ@2,4BST7@82117 NA|NA|NA MAG.T1.121_01366 338966.Ppro_2005 1.7e-46 193.7 Desulfuromonadales ccdA ko:K06196 ko00000,ko02000 5.A.1.2 Bacteria 1RCP7@1224,2WJCK@28221,42Q7J@68525,43T44@69541,COG0785@1,COG0785@2 NA|NA|NA O PFAM cytochrome c biogenesis protein, transmembrane region MAG.T1.121_01367 1521187.JPIM01000137_gene2071 4.2e-38 164.9 Chloroflexia hyaE GO:0003674,GO:0005048,GO:0005488,GO:0033218,GO:0042277 ko:K03619,ko:K07152 ko00000,ko03029 Bacteria 2G6UW@200795,375R3@32061,COG1999@1,COG1999@2 NA|NA|NA S Electron transport protein SCO1 SenC MAG.T1.121_01368 357808.RoseRS_3482 1.1e-24 120.2 Chloroflexia VY92_09940 ko:K09796 ko00000,ko03110 Bacteria 2G757@200795,375SN@32061,COG2847@1,COG2847@2 NA|NA|NA S Copper chaperone PCu(A)C MAG.T1.121_01369 1313172.YM304_28410 1.1e-06 60.1 Actinobacteria 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 Bacteria 2HC6V@201174,COG3794@1,COG3794@2 NA|NA|NA C PFAM blue (type 1) copper domain protein MAG.T1.121_01370 1128421.JAGA01000002_gene1632 1.4e-64 254.6 unclassified Bacteria ycnJ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K07156,ko:K07245,ko:K14166 ko00000,ko02000 9.B.62.1,9.B.62.2 Bacteria 2NPS1@2323,COG1276@1,COG1276@2,COG2010@1,COG2010@2,COG2372@1,COG2372@2 NA|NA|NA P Evidence 5 No homology to any previously reported sequences MAG.T1.121_01371 1382304.JNIL01000001_gene49 2.4e-14 85.9 Alicyclobacillaceae ycnJ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K07156,ko:K14166 ko00000,ko02000 9.B.62.2 Bacteria 1V0AI@1239,279JR@186823,4HDZZ@91061,COG1276@1,COG1276@2,COG2372@1,COG2372@2 NA|NA|NA P Copper resistance protein D MAG.T1.121_01372 1382356.JQMP01000003_gene1492 4.1e-33 147.9 Chloroflexi Bacteria 2G8VM@200795,32UTS@2,arCOG08811@1 NA|NA|NA MAG.T1.121_01374 926569.ANT_02430 1.9e-16 93.6 Chloroflexi Bacteria 2A1JS@1,2G9H1@200795,30PTP@2 NA|NA|NA MAG.T1.121_01377 1218173.BALCAV_0222095 1.3e-51 209.9 Bacillus ko:K01996 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 1TPW4@1239,1ZBFK@1386,4HABJ@91061,COG0410@1,COG0410@2 NA|NA|NA E COG0410 ABC-type branched-chain amino acid transport systems, ATPase component MAG.T1.121_01378 1157708.KB907456_gene2289 2.1e-52 212.6 Comamonadaceae MA20_07790 ko:K01995,ko:K01996 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 1MXHT@1224,2VKMU@28216,4AD47@80864,COG0411@1,COG0411@2 NA|NA|NA E PFAM ABC transporter related MAG.T1.121_01379 871963.Desdi_3046 6.1e-52 211.5 Peptococcaceae ko:K01998 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 1V7V4@1239,24K2K@186801,265DU@186807,COG4177@1,COG4177@2 NA|NA|NA U PFAM Branched-chain amino acid transport system permease component MAG.T1.121_01380 666684.AfiDRAFT_2648 2.4e-68 265.8 Bradyrhizobiaceae ko:K01997 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 1MVND@1224,2TSCF@28211,3JQTN@41294,COG0559@1,COG0559@2 NA|NA|NA E Belongs to the binding-protein-dependent transport system permease family MAG.T1.121_01381 644966.Tmar_1791 4.9e-64 251.9 Clostridia ko:K01999 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 1V76C@1239,25BU4@186801,COG0683@1,COG0683@2 NA|NA|NA E Amino acid amide ABC transporter substrate-binding protein, HAAT family MAG.T1.121_01382 1380391.JIAS01000012_gene3982 8.6e-80 303.9 Rhodospirillales 1.1.1.157 ko:K00074,ko:K18612 ko00360,ko00362,ko00650,ko00750,ko01100,ko01120,map00360,map00362,map00650,map00750,map01100,map01120 R01976,R04524,R05576,R06941 RC00029,RC00075,RC00117 ko00000,ko00001,ko01000 Bacteria 1MVVD@1224,2JYPS@204441,2U0T1@28211,COG1250@1,COG1250@2 NA|NA|NA I 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain MAG.T1.121_01383 552811.Dehly_0234 5.5e-53 214.5 Dehalococcoidia Bacteria 2G5KB@200795,34D4D@301297,COG1028@1,COG1028@2 NA|NA|NA IQ KR domain MAG.T1.121_01384 573413.Spirs_3288 2.1e-107 396.0 Spirochaetes aspC2 GO:0003674,GO:0003824,GO:0005488,GO:0008144,GO:0008483,GO:0016740,GO:0016769,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.6.1.30 ko:K18608 ko00750,ko01120,map00750,map01120 R01712 RC00008,RC00048 ko00000,ko00001,ko01000 Bacteria 2J84T@203691,COG0075@1,COG0075@2 NA|NA|NA E PFAM aminotransferase class V MAG.T1.121_01385 1961.JOAK01000010_gene6679 1.6e-68 266.9 Actinobacteria Bacteria 2GWFP@201174,COG4325@1,COG4325@2 NA|NA|NA S Predicted membrane protein (DUF2254) MAG.T1.121_01386 472175.EL18_00026 2.7e-69 269.2 Phyllobacteriaceae ko:K02058,ko:K07335 M00221 ko00000,ko00002,ko02000 3.A.1.2 Bacteria 1R54V@1224,2U1WQ@28211,43HFZ@69277,COG1744@1,COG1744@2 NA|NA|NA S ABC transporter substrate-binding protein PnrA-like MAG.T1.121_01387 102129.Lepto7375DRAFT_4225 1.7e-20 105.9 Oscillatoriales ko:K07491 ko00000 Bacteria 1G6SS@1117,1HBRS@1150,COG1943@1,COG1943@2 NA|NA|NA L PFAM Transposase MAG.T1.121_01388 1499967.BAYZ01000131_gene341 2.9e-59 235.7 Bacteria rbsC-2 ko:K02057 M00221 ko00000,ko00002,ko02000 3.A.1.2 Bacteria COG1079@1,COG1079@2 NA|NA|NA S Belongs to the binding-protein-dependent transport system permease family MAG.T1.121_01389 1380391.JIAS01000012_gene3979 2.2e-69 269.6 Rhodospirillales ko:K02057 M00221 ko00000,ko00002,ko02000 3.A.1.2 Bacteria 1MX6V@1224,2JRJ1@204441,2TUGD@28211,COG4603@1,COG4603@2 NA|NA|NA S Branched-chain amino acid transport system / permease component MAG.T1.121_01390 693661.Arcve_0450 8.3e-120 437.6 Euryarchaeota rbsA 3.6.3.17 ko:K02056 M00221 ko00000,ko00002,ko01000,ko02000 3.A.1.2 Archaea 2XUEG@28890,COG3845@1,arCOG00186@2157 NA|NA|NA E transport systems ATPase components MAG.T1.121_01391 1121924.ATWH01000009_gene62 8.3e-57 227.3 Microbacteriaceae hagH GO:0003674,GO:0003824,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009111,GO:0009987,GO:0016787,GO:0016788,GO:0017144,GO:0034641,GO:0042365,GO:0042737,GO:0042816,GO:0042820,GO:0044237,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046483,GO:0046700,GO:0047585,GO:0052689,GO:0071704,GO:0072524,GO:0072526,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 3.1.1.27,3.1.1.81 ko:K13075,ko:K18610 ko00750,ko01120,ko02024,map00750,map01120,map02024 R02992,R08970 RC00713,RC00826 ko00000,ko00001,ko01000 Bacteria 2IB2K@201174,4FQNV@85023,COG0491@1,COG0491@2 NA|NA|NA S Metallo-beta-lactamase superfamily MAG.T1.121_01393 316058.RPB_4416 9.7e-149 534.3 Bradyrhizobiaceae Bacteria 1MUEA@1224,2TWGU@28211,3JQT8@41294,COG1529@1,COG1529@2 NA|NA|NA C aldehyde oxidase and xanthine dehydrogenase, a b hammerhead MAG.T1.121_01394 316058.RPB_4413 4.1e-44 184.5 Bradyrhizobiaceae 1.2.5.3,1.3.99.16 ko:K03518,ko:K07302,ko:K13483 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103,R11168 RC00143,RC02800 ko00000,ko00001,ko00002,ko01000 Bacteria 1RFP6@1224,2U75E@28211,3JYY5@41294,COG2080@1,COG2080@2 NA|NA|NA C [2Fe-2S] binding domain MAG.T1.121_01395 1038860.AXAP01000001_gene6513 5.3e-29 134.4 Bradyrhizobiaceae xdhB 1.2.5.3 ko:K03519 R11168 RC02800 ko00000,ko01000 Bacteria 1MUDB@1224,2TTJF@28211,3K3D3@41294,COG1319@1,COG1319@2 NA|NA|NA C CO dehydrogenase flavoprotein C-terminal domain MAG.T1.121_01396 525904.Tter_0881 3.1e-281 974.2 unclassified Bacteria acsA GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 2NNSQ@2323,COG0365@1,COG0365@2 NA|NA|NA I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA MAG.T1.121_01398 479434.Sthe_0171 1.4e-14 86.3 Thermomicrobia ko:K03686,ko:K05801,ko:K17867 ko00000,ko03012,ko03029,ko03110 Bacteria 27YJ1@189775,2GBGQ@200795,COG0484@1,COG0484@2 NA|NA|NA O DnaJ molecular chaperone homology domain MAG.T1.121_01399 383372.Rcas_2852 5e-37 161.8 Chloroflexi 3.5.3.1,3.5.3.11 ko:K01476,ko:K01480 ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146 M00029,M00133,M00134 R00551,R01157 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 Bacteria 2G8DY@200795,COG0010@1,COG0010@2 NA|NA|NA E Belongs to the arginase family MAG.T1.121_01401 479434.Sthe_2043 2.2e-15 89.4 Thermomicrobia ecfR ko:K02405 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 ko00000,ko00001,ko02035,ko03021 Bacteria 27YQ5@189775,2GA1X@200795,COG1595@1,COG1595@2 NA|NA|NA K DNA-templated transcription, initiation MAG.T1.121_01402 479434.Sthe_2024 1.8e-187 662.1 Thermomicrobia cbs GO:0003674,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008144,GO:0016020,GO:0019842,GO:0030170,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0071944,GO:0097159,GO:1901363 2.5.1.47,4.2.1.22 ko:K01697,ko:K01738 ko00260,ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021,M00035,M00338 R00891,R00897,R01290,R03601,R04859,R04942 RC00020,RC00056,RC00069,RC00256,RC00489,RC01246,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 Bacteria 27YAJ@189775,2G698@200795,COG0031@1,COG0031@2,COG3620@1,COG3620@2 NA|NA|NA E Cysteine synthase MAG.T1.121_01403 479434.Sthe_2023 1.6e-152 545.8 Chloroflexi metB GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009092,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0017144,GO:0019279,GO:0019343,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071265,GO:0071266,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.48,4.4.1.1,4.4.1.8 ko:K01739,ko:K01758,ko:K01760 ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017,M00338 R00782,R00999,R01001,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04941,R04944,R04945,R04946,R09366 RC00020,RC00056,RC00069,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000,ko04147 iNJ661.Rv1079 Bacteria 2G5M2@200795,COG0626@1,COG0626@2 NA|NA|NA E PFAM Cys Met metabolism pyridoxal-phosphate-dependent protein MAG.T1.121_01405 1382356.JQMP01000003_gene2598 4.5e-34 151.8 Thermomicrobia ko:K03624,ko:K06140 ko00000,ko03000,ko03021 Bacteria 27Y9B@189775,2G6U9@200795,COG0782@1,COG0782@2 NA|NA|NA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides MAG.T1.121_01406 479434.Sthe_1110 9.8e-174 616.7 Thermomicrobia lysS GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iAF1260.b4129,iECDH1ME8569_1439.ECDH1ME8569_3989,iECW_1372.ECW_m4490,iEcDH1_1363.EcDH1_3862,iJO1366.b4129,iWFL_1372.ECW_m4490 Bacteria 27XMG@189775,2G65Z@200795,COG1190@1,COG1190@2 NA|NA|NA J Belongs to the class-II aminoacyl-tRNA synthetase family MAG.T1.121_01408 1303692.SFUL_5320 3.7e-19 102.8 Actinobacteria ylcC 3.4.22.70 ko:K07284 ko00000,ko01000,ko01002,ko01011 Bacteria 2I91T@201174,COG3764@1,COG3764@2 NA|NA|NA M peptidase C60 sortase A and B MAG.T1.121_01409 383372.Rcas_3032 1.8e-63 250.4 Chloroflexia adeS 2.7.13.3 ko:K02484,ko:K07642,ko:K07644,ko:K18143 ko01501,ko02020,map01501,map02020 M00450,M00452,M00645,M00646,M00648,M00649,M00655,M00745 ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022 Bacteria 2G68T@200795,375B4@32061,COG2770@1,COG2770@2,COG5002@1,COG5002@2 NA|NA|NA T histidine kinase HAMP region domain protein MAG.T1.121_01410 479434.Sthe_2027 8.3e-65 253.8 Thermomicrobia Bacteria 27Z4W@189775,2G5TG@200795,COG0745@1,COG0745@2 NA|NA|NA K Transcriptional regulatory protein, C terminal MAG.T1.121_01411 479434.Sthe_2188 5.5e-63 248.4 Chloroflexi 1.3.1.74 ko:K08070 ko00000,ko01000 Bacteria 2G6KV@200795,COG0265@1,COG0265@2 NA|NA|NA O PFAM peptidase S1 and S6, chymotrypsin Hap MAG.T1.121_01412 1382356.JQMP01000003_gene1858 2.1e-117 428.7 Thermomicrobia sucD 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 Bacteria 27XS4@189775,2G5R4@200795,COG0074@1,COG0074@2 NA|NA|NA C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit MAG.T1.121_01413 479434.Sthe_1783 7.6e-123 447.2 Thermomicrobia sucC GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009361,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0032991,GO:0042709,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045333,GO:0055114,GO:0071704,GO:0072350,GO:1902494 6.2.1.5,6.2.1.9 ko:K01903,ko:K14067 ko00020,ko00630,ko00640,ko00660,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00630,map00640,map00660,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00346,M00374,M00620 R00405,R01256,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2261,iPC815.YPO1115,iUMNK88_1353.UMNK88_764,iYO844.BSU16090 Bacteria 27XMH@189775,2G68A@200795,COG0045@1,COG0045@2 NA|NA|NA C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit MAG.T1.121_01414 1385511.N783_05640 1.2e-14 87.4 Bacilli Bacteria 1V1G8@1239,4HH8Z@91061,COG1670@1,COG1670@2 NA|NA|NA J COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins MAG.T1.121_01416 479434.Sthe_2062 2.8e-87 329.3 Thermomicrobia mgtE 3.6.1.1 ko:K04767,ko:K06213,ko:K15986 ko00190,map00190 ko00000,ko00001,ko01000,ko02000 1.A.26.1 Bacteria 27Y1H@189775,2G6H7@200795,COG2239@1,COG2239@2 NA|NA|NA P MgtE intracellular N domain MAG.T1.121_01417 926550.CLDAP_13640 9.3e-135 487.3 Bacteria ko:K02027 M00207 ko00000,ko00002,ko02000 3.A.1.1 Bacteria COG1653@1,COG1653@2 NA|NA|NA G carbohydrate transport MAG.T1.121_01418 926550.CLDAP_13650 1.6e-86 327.0 Bacteria ko:K02025,ko:K05814,ko:K10118,ko:K10237,ko:K10241,ko:K15771,ko:K17235,ko:K17242,ko:K17316 ko02010,map02010 M00196,M00198,M00204,M00206,M00207,M00491,M00600,M00602,M00605 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.17,3.A.1.1.2,3.A.1.1.23,3.A.1.1.24,3.A.1.1.28,3.A.1.1.3,3.A.1.1.30,3.A.1.1.34,3.A.1.1.39 Bacteria COG1175@1,COG1175@2 NA|NA|NA P transmembrane transport MAG.T1.121_01419 926550.CLDAP_13660 3.2e-84 318.5 Bacteria ko:K02026 M00207 ko00000,ko00002,ko02000 3.A.1.1 Bacteria COG0395@1,COG0395@2 NA|NA|NA P glycerophosphodiester transmembrane transport MAG.T1.121_01420 1242864.D187_009247 6.4e-26 125.6 Proteobacteria ko:K02027 M00207 ko00000,ko00002,ko02000 3.A.1.1 Bacteria 1R4UG@1224,COG1653@1,COG1653@2 NA|NA|NA G ABC-type sugar transport system periplasmic component MAG.T1.121_01421 1382356.JQMP01000003_gene1637 1.4e-32 147.5 Thermomicrobia Bacteria 27Z0S@189775,2GA3J@200795,COG0726@1,COG0726@2 NA|NA|NA G Polysaccharide deacetylase MAG.T1.121_01423 159450.NH14_05435 9.6e-11 73.2 Burkholderiaceae Bacteria 1K4N1@119060,1RH69@1224,2VUMS@28216,COG3247@1,COG3247@2 NA|NA|NA S Short repeat of unknown function (DUF308) MAG.T1.121_01425 926550.CLDAP_13670 1.2e-134 486.9 Chloroflexi 2.7.1.12,2.7.1.17,2.7.1.215,2.7.1.5 ko:K00848,ko:K00851,ko:K00854,ko:K00862 ko00030,ko00040,ko00051,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00040,map00051,map01100,map01110,map01120,map01130,map01200 M00014 R01639,R01737,R01902,R03014,R11536 RC00002,RC00017,RC00538 ko00000,ko00001,ko00002,ko01000 Bacteria 2G7KS@200795,COG1070@1,COG1070@2 NA|NA|NA G FGGY family of carbohydrate kinases, N-terminal domain MAG.T1.121_01427 1123023.JIAI01000018_gene2470 2e-82 312.8 Bacteria ko:K18565 ko00332,ko01130,map00332,map01130 R10740,R10741,R10742 RC03267,RC03268,RC03269 ko00000,ko00001,ko01000 Bacteria COG5285@1,COG5285@2 NA|NA|NA Q dioxygenase activity MAG.T1.121_01428 1380347.JNII01000005_gene3189 3.1e-109 402.1 Frankiales xyoA 1.1.3.41,1.1.3.8 ko:K00103,ko:K00594 ko00040,ko00051,ko00053,ko01100,map00040,map00051,map00053,map01100 M00129 R00647,R03184,R07152,R10053,R11620 RC00108,RC00133,RC00195,RC00346,RC00869 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ33@201174,4ETX5@85013,COG0277@1,COG0277@2 NA|NA|NA C D-arabinono-1,4-lactone oxidase MAG.T1.121_01429 1349820.M707_19515 3.9e-101 374.8 Micrococcaceae yvbT ko:K07496 ko00000 Bacteria 1W89F@1268,2GJ66@201174,COG2141@1,COG2141@2 NA|NA|NA C Luciferase-like monooxygenase MAG.T1.121_01430 216594.MMAR_2520 9.6e-65 254.2 Mycobacteriaceae 1.3.8.4 ko:K00253,ko:K18244 ko00280,ko01100,map00280,map01100 M00036 R04095 RC00246 ko00000,ko00001,ko00002,ko01000 Bacteria 23D3C@1762,2H2DQ@201174,COG1960@1,COG1960@2 NA|NA|NA C but involved in lipid degradation MAG.T1.121_01431 1444306.JFZC01000051_gene761 4.3e-16 92.0 Bacilli atl 3.2.1.96,3.5.1.28,6.1.1.12 ko:K01227,ko:K01876,ko:K11060,ko:K13714,ko:K21472 ko00511,ko00970,map00511,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01002,ko01007,ko01011,ko02042,ko03016,ko03029 GH73 Bacteria 1V0NC@1239,4HNGM@91061,COG3807@1,COG3807@2,COG4193@1,COG4193@2 NA|NA|NA GT Bacterial SH3 domain MAG.T1.121_01432 319795.Dgeo_0953 4.5e-48 198.7 Deinococcus-Thermus Bacteria 1WND3@1297,COG1680@1,COG1680@2 NA|NA|NA V Beta-lactamase MAG.T1.121_01433 1298864.AUEQ01000001_gene4326 2.3e-82 312.8 Mycobacteriaceae ko:K06907 ko00000 Bacteria 2386C@1762,2GMJA@201174,COG3497@1,COG3497@2 NA|NA|NA S Phage tail sheath C-terminal domain MAG.T1.121_01434 309801.trd_0306 3.5e-296 1024.2 Thermomicrobia ppdK 2.7.3.13,2.7.9.1 ko:K01006,ko:K22424 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 Bacteria 27Y4S@189775,2G5W2@200795,COG0574@1,COG0574@2,COG1080@1,COG1080@2 NA|NA|NA G Belongs to the PEP-utilizing enzyme family MAG.T1.121_01435 479434.Sthe_0159 0.0 1170.6 Thermomicrobia Bacteria 27YN6@189775,2G7US@200795,COG1112@1,COG1112@2,COG2251@1,COG2251@2 NA|NA|NA L AAA domain MAG.T1.121_01436 595537.Varpa_1306 3.9e-59 235.7 Betaproteobacteria 3.1.1.31 ko:K07404 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R02035 RC00537 ko00000,ko00001,ko00002,ko01000 Bacteria 1R5TI@1224,2VN3Z@28216,COG2706@1,COG2706@2 NA|NA|NA G Lactonase, 7-bladed beta-propeller MAG.T1.121_01437 1229780.BN381_130195 2.1e-24 119.0 unclassified Actinobacteria (class) ko:K03321 ko00000,ko02000 2.A.53.3 Bacteria 2GJCB@201174,3UX4F@52018,COG0659@1,COG0659@2 NA|NA|NA P Sulfate permease family MAG.T1.121_01438 404589.Anae109_3236 1.7e-32 146.4 delta/epsilon subdivisions ko:K03321 ko00000,ko02000 2.A.53.3 Bacteria 1MWDF@1224,43AD6@68525,COG0659@1,COG0659@2 NA|NA|NA P Sulfate transporter antisigma-factor antagonist STAS MAG.T1.121_01439 42256.RradSPS_0535 8.1e-17 93.6 Rubrobacteria kefB ko:K03455 ko00000 2.A.37 Bacteria 2H11C@201174,4CTJD@84995,COG1226@1,COG1226@2 NA|NA|NA P Ion channel MAG.T1.121_01440 1121929.KB898663_gene1123 4.9e-07 61.2 Bacilli Bacteria 1V6P2@1239,4HIWN@91061,COG0454@1,COG0456@2 NA|NA|NA K family acetyltransferase MAG.T1.121_01441 44060.JODL01000004_gene2456 2.3e-70 271.9 Actinobacteria apl 3.1.3.1 ko:K01077 ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020 M00126 R02135,R04620 RC00017 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 Bacteria 2GN43@201174,COG0586@1,COG0586@2 NA|NA|NA S Pfam SNARE associated Golgi protein MAG.T1.121_01442 1121377.KB906398_gene2411 3.6e-22 112.8 Deinococcus-Thermus Bacteria 1WK3B@1297,COG2133@1,COG2133@2 NA|NA|NA G pyrroloquinoline quinone binding MAG.T1.121_01444 479434.Sthe_2900 6e-142 510.8 Thermomicrobia amaB GO:0003674,GO:0005488,GO:0005515,GO:0042802 3.5.1.6,3.5.1.87,3.5.3.9 ko:K02083,ko:K06016,ko:K09967 ko00230,ko00240,ko01100,ko01120,map00230,map00240,map01100,map01120 M00046 R00905,R02423,R04666 RC00064,RC00096 ko00000,ko00001,ko00002,ko01000,ko01002 Bacteria 27Z48@189775,2GBEA@200795,COG0624@1,COG0624@2 NA|NA|NA E Peptidase dimerisation domain MAG.T1.121_01445 526227.Mesil_2725 2.3e-34 152.5 Deinococcus-Thermus GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005267,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015267,GO:0015318,GO:0015672,GO:0016043,GO:0022607,GO:0022803,GO:0022838,GO:0022840,GO:0022841,GO:0022842,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0043933,GO:0044085,GO:0046873,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055085,GO:0065003,GO:0071804,GO:0071805,GO:0071840,GO:0098655,GO:0098660,GO:0098662 Bacteria 1WN5V@1297,COG3548@1,COG3548@2 NA|NA|NA S Protein of unknown function (DUF1211) MAG.T1.121_01446 867903.ThesuDRAFT_01569 1.3e-67 263.8 Clostridia Bacteria 1TQ44@1239,247SG@186801,COG0006@1,COG0006@2 NA|NA|NA E creatinase MAG.T1.121_01448 321332.CYB_1473 2.9e-33 149.8 Synechococcus 5.2.1.8 ko:K01802 ko00000,ko01000 Bacteria 1G5BD@1117,1H0AB@1129,COG0652@1,COG0652@2 NA|NA|NA O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides MAG.T1.121_01449 479434.Sthe_1318 1e-36 161.8 Chloroflexi ppiB GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0031224,GO:0031226,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.7.11.1,5.2.1.8 ko:K01802,ko:K03768,ko:K12132 ko00000,ko01000,ko01001,ko03110 Bacteria 2G6RE@200795,COG0652@1,COG0652@2 NA|NA|NA M PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides MAG.T1.121_01450 1123023.JIAI01000010_gene8658 8e-40 170.6 Pseudonocardiales yiiM GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009636,GO:0009987,GO:0019748,GO:0042221,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0098754 Bacteria 2GMCN@201174,4EAZU@85010,COG2258@1,COG2258@2 NA|NA|NA S MOSC domain MAG.T1.121_01451 552811.Dehly_0588 3.1e-22 112.5 Dehalococcoidia ko:K07025 ko00000 Bacteria 2G78N@200795,34D8N@301297,COG1011@1,COG1011@2 NA|NA|NA S Haloacid dehalogenase-like hydrolase MAG.T1.121_01452 525904.Tter_1857 6.3e-25 120.6 Bacteria Bacteria COG2141@1,COG2141@2 NA|NA|NA C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases MAG.T1.121_01453 926550.CLDAP_00820 2e-42 178.7 Chloroflexi pstA ko:K02038 ko02010,map02010 M00222 ko00000,ko00001,ko00002,ko02000 3.A.1.7 Bacteria 2G6BI@200795,COG0581@1,COG0581@2 NA|NA|NA P TIGRFAM phosphate ABC transporter, inner membrane subunit PstA MAG.T1.121_01454 926550.CLDAP_00810 3.5e-101 374.8 Chloroflexi pstB 3.6.3.27 ko:K02036 ko02010,map02010 M00222 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 Bacteria 2G646@200795,COG1117@1,COG1117@2 NA|NA|NA P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system MAG.T1.121_01455 1382356.JQMP01000004_gene657 1.5e-59 236.1 Thermomicrobia phoU ko:K02039 ko00000 Bacteria 27XPS@189775,2G6HD@200795,COG0704@1,COG0704@2 NA|NA|NA P Plays a role in the regulation of phosphate uptake MAG.T1.121_01458 309801.trd_0014 1.6e-48 199.5 Thermomicrobia trmH GO:0001510,GO:0002128,GO:0002938,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008175,GO:0008757,GO:0009020,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0106050,GO:0140098,GO:0140101,GO:1901360 2.1.1.185,2.1.1.34 ko:K00556,ko:K03218,ko:K03437,ko:K15333 ko00000,ko01000,ko03009,ko03016,ko03036 Bacteria 27Y5B@189775,2GA03@200795,COG0566@1,COG0566@2 NA|NA|NA J Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA MAG.T1.121_01459 667121.ET1_05_01960 3.8e-23 114.8 Gammaproteobacteria yhiD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K07507 ko00000,ko02000 9.B.20 Bacteria 1MURJ@1224,1RPR1@1236,COG1285@1,COG1285@2 NA|NA|NA S Membrane MAG.T1.121_01460 525904.Tter_0505 1.1e-26 126.7 unclassified Bacteria grxC 3.4.21.107 ko:K03676,ko:K04771 ko01503,ko02020,map01503,map02020 M00728 ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 Bacteria 2NQ8T@2323,COG0265@1,COG0265@2,COG0695@1,COG0695@2 NA|NA|NA O Glutaredoxin MAG.T1.121_01461 1382356.JQMP01000003_gene1428 4.9e-161 574.3 Thermomicrobia ffh GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006605,GO:0006612,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0030312,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0040007,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046907,GO:0048500,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0071944,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1990904 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 Bacteria 27Y15@189775,2G627@200795,COG0541@1,COG0541@2 NA|NA|NA U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY MAG.T1.121_01462 479434.Sthe_0345 1.2e-124 453.0 Thermomicrobia ftsY ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 Bacteria 27XH9@189775,2G63M@200795,COG0552@1,COG0552@2 NA|NA|NA U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) MAG.T1.121_01463 479434.Sthe_0347 3.2e-60 238.4 Thermomicrobia radC ko:K03630 ko00000 Bacteria 27XF2@189775,2G6BK@200795,COG2003@1,COG2003@2 NA|NA|NA L RadC-like JAB domain MAG.T1.121_01464 1382356.JQMP01000003_gene1667 8.6e-49 200.7 Thermomicrobia 1.5.98.2 ko:K00320 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00567 R04464 RC01607 ko00000,ko00001,ko00002,ko01000 Bacteria 27Y8J@189775,2GB9A@200795,COG2141@1,COG2141@2 NA|NA|NA C Luciferase-like monooxygenase MAG.T1.121_01465 1121033.AUCF01000032_gene2609 2.7e-33 149.8 Rhodospirillales 2.7.7.65 ko:K13590 ko04112,map04112 ko00000,ko00001,ko01000 Bacteria 1NC00@1224,2JRXT@204441,2TU9T@28211,COG2199@1,COG3706@2 NA|NA|NA T COG2199 FOG GGDEF domain MAG.T1.121_01467 479434.Sthe_2367 2.1e-169 601.7 Thermomicrobia mbl ko:K03569 ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 Bacteria 27Y3P@189775,2G5KV@200795,COG1077@1,COG1077@2 NA|NA|NA D Cell division protein FtsA MAG.T1.121_01468 383372.Rcas_2645 9.1e-159 567.0 Chloroflexia malQ 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 R05196 RC00049 ko00000,ko00001,ko01000 GH77 iJN678.malQ Bacteria 2G668@200795,376Q1@32061,COG1640@1,COG1640@2 NA|NA|NA G PFAM glycoside hydrolase, family 77 MAG.T1.121_01469 316274.Haur_4461 8.6e-163 580.5 Chloroflexia GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901576 2.4.1.18 ko:K03406,ko:K16149 ko00500,ko01100,ko01110,ko02020,ko02030,map00500,map01100,map01110,map02020,map02030 M00565 R02110 ko00000,ko00001,ko00002,ko01000,ko02035 GH57 Bacteria 2GBQW@200795,3764R@32061,COG1543@1,COG1543@2 NA|NA|NA G Belongs to the glycosyl hydrolase 57 family MAG.T1.121_01470 1128421.JAGA01000003_gene2942 6.8e-60 238.4 unclassified Bacteria treS GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016310,GO:0034637,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046835,GO:0071704,GO:0071944,GO:1901576 2.4.1.18,2.7.1.175,3.2.1.1,5.4.99.16 ko:K00700,ko:K05343,ko:K16146 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01557,R02108,R02110,R02112,R09945,R11262 RC00002,RC00078,RC01816 ko00000,ko00001,ko00002,ko01000,ko04147 CBM48,GH13 Bacteria 2NR3X@2323,COG3281@1,COG3281@2 NA|NA|NA G Phosphotransferase enzyme family MAG.T1.121_01471 1128421.JAGA01000004_gene2674 7.1e-215 753.4 unclassified Bacteria treS 3.2.1.1,5.4.99.16 ko:K05343 ko00500,ko01100,map00500,map01100 R01557,R02108,R02112,R11262 RC01816 ko00000,ko00001,ko01000 GH13 Bacteria 2NQND@2323,COG0366@1,COG0366@2 NA|NA|NA G Maltogenic Amylase, C-terminal domain MAG.T1.121_01472 1380394.JADL01000005_gene5439 1.4e-199 703.0 Rhodospirillales glgE 2.4.99.16 ko:K16147 ko00500,ko01100,map00500,map01100 R09994 ko00000,ko00001,ko01000 GH13 Bacteria 1MWBZ@1224,2JQZS@204441,2TVJ1@28211,COG0366@1,COG0366@2 NA|NA|NA G Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB MAG.T1.121_01473 1125718.HMPREF1318_0537 1.3e-197 696.4 Actinobacteria glgX 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 ko00000,ko00001,ko00002,ko01000 CBM48,GH13 Bacteria 2GJ00@201174,4D3BA@85005,COG1523@1,COG1523@2 NA|NA|NA G Belongs to the glycosyl hydrolase 13 family MAG.T1.121_01474 479434.Sthe_1441 5.3e-49 200.7 Chloroflexi yajQ GO:0000049,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0009987,GO:0017076,GO:0019001,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033554,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0097159,GO:0097367,GO:1901265,GO:1901363 ko:K09767 ko00000 Bacteria 2G6TD@200795,COG1666@1,COG1666@2 NA|NA|NA S Belongs to the UPF0234 family MAG.T1.121_01475 479434.Sthe_1442 5.4e-147 527.7 Thermomicrobia rimO GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016782,GO:0018193,GO:0018197,GO:0018198,GO:0018339,GO:0019538,GO:0035596,GO:0035599,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901564 2.8.4.4 ko:K14441 R10652 RC00003,RC03217 ko00000,ko01000,ko03009 Bacteria 27XFB@189775,2G5ZJ@200795,COG0621@1,COG0621@2 NA|NA|NA H Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 MAG.T1.121_01476 479434.Sthe_1443 3.3e-61 242.3 Thermomicrobia htrB GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.3.1.241,2.3.1.265 ko:K02517,ko:K22311 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 Bacteria 27Z5D@189775,2G9GW@200795,COG1560@1,COG1560@2 NA|NA|NA M Bacterial lipid A biosynthesis acyltransferase MAG.T1.121_01477 479434.Sthe_1445 8.3e-50 203.8 Thermomicrobia 2.7.8.11,2.7.8.41,2.7.8.5,2.7.8.8 ko:K00995,ko:K00999,ko:K08744,ko:K17103 ko00260,ko00562,ko00564,ko01100,ko01110,ko04070,map00260,map00562,map00564,map01100,map01110,map04070 M00093 R01800,R01801,R01802,R02030 RC00002,RC00017,RC00078,RC02795 ko00000,ko00001,ko00002,ko01000 Bacteria 27YAM@189775,2G7HQ@200795,COG0558@1,COG0558@2 NA|NA|NA I Belongs to the CDP-alcohol phosphatidyltransferase class-I family MAG.T1.121_01479 479434.Sthe_1448 4.9e-62 245.7 Thermomicrobia 5.2.1.8 ko:K03769,ko:K07533 ko00000,ko01000,ko03110 Bacteria 27XG1@189775,2G6RV@200795,COG0760@1,COG0760@2 NA|NA|NA O SurA N-terminal domain MAG.T1.121_01480 479434.Sthe_1449 7.7e-24 116.7 Thermomicrobia rpsR GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02963 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 27YKT@189775,2G756@200795,COG0238@1,COG0238@2 NA|NA|NA J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit MAG.T1.121_01481 479434.Sthe_1450 4.7e-24 117.9 Thermomicrobia ssb ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 ko00000,ko00001,ko03029,ko03032,ko03400 Bacteria 27YIZ@189775,2G6YE@200795,COG0629@1,COG0629@2 NA|NA|NA L Single-strand binding protein family MAG.T1.121_01482 309801.trd_1249 3.4e-15 89.0 Thermomicrobia rpsF GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0019843,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071944,GO:0097159,GO:1901363,GO:1990904 ko:K02990 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011,ko03029 Bacteria 27YM8@189775,2G7DG@200795,COG0360@1,COG0360@2 NA|NA|NA J Binds together with S18 to 16S ribosomal RNA MAG.T1.121_01483 309801.trd_1303 2.7e-123 448.7 Thermomicrobia 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 Bacteria 27XZ4@189775,2G5MC@200795,COG0436@1,COG0436@2 NA|NA|NA E Cys/Met metabolism PLP-dependent enzyme MAG.T1.121_01484 1205680.CAKO01000042_gene5387 2.6e-42 178.3 Rhodospirillales Bacteria 1RHMZ@1224,2JWKB@204441,2U5PZ@28211,COG0251@1,COG0251@2 NA|NA|NA J YjgF/chorismate_mutase-like, putative endoribonuclease MAG.T1.121_01485 309801.trd_1081 1.5e-37 162.5 Thermomicrobia greA ko:K03624,ko:K04760 ko00000,ko03021 Bacteria 27YAU@189775,2G6U9@200795,COG0782@1,COG0782@2 NA|NA|NA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides MAG.T1.121_01486 485913.Krac_7993 2.4e-180 638.6 Bacteria metG GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria COG0143@1,COG0143@2 NA|NA|NA J methionyl-tRNA aminoacylation MAG.T1.121_01487 1382356.JQMP01000003_gene1740 4.3e-78 298.5 Thermomicrobia Bacteria 27XMQ@189775,2G8XK@200795,COG0640@1,COG0640@2 NA|NA|NA K helix_turn_helix, Arsenical Resistance Operon Repressor MAG.T1.121_01488 479434.Sthe_2323 6.3e-23 113.6 Thermomicrobia Bacteria 27ZAK@189775,2G9GF@200795,COG1917@1,COG1917@2 NA|NA|NA S AraC-like ligand binding domain MAG.T1.121_01490 348780.NP_3878A 1.8e-58 233.0 Halobacteria 2.5.1.3,3.2.2.24 ko:K00788,ko:K05521 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 Archaea 23TFB@183963,2XV15@28890,COG1397@1,arCOG04448@2157 NA|NA|NA O ADP-ribosyl-(Dinitrogen reductase) hydrolase MAG.T1.121_01491 1382356.JQMP01000003_gene1687 4.4e-152 544.7 Chloroflexi melA GO:0000166,GO:0003674,GO:0003824,GO:0004553,GO:0004557,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005994,GO:0005995,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0015925,GO:0016052,GO:0016787,GO:0016798,GO:0030145,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046352,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0051287,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901575 3.2.1.22,3.2.1.86 ko:K01222,ko:K07406 ko00010,ko00052,ko00500,ko00561,ko00600,ko00603,map00010,map00052,map00500,map00561,map00600,map00603 R00839,R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05133,R05134,R05549,R05961,R06091 RC00049,RC00059,RC00171,RC00451,RC00714 ko00000,ko00001,ko01000 GT4 iECH74115_1262.ECH74115_5633,iECSP_1301.ECSP_5218,iECs_1301.ECs5101 Bacteria 2G5M6@200795,COG1486@1,COG1486@2 NA|NA|NA G Family 4 glycosyl hydrolase MAG.T1.121_01492 926554.KI912619_gene928 7.1e-193 680.6 Deinococcus-Thermus bgaB 3.2.1.23 ko:K12308 ko00052,map00052 R01105 RC00452 ko00000,ko00001,ko01000 Bacteria 1WJAT@1297,COG1874@1,COG1874@2 NA|NA|NA G Beta-galactosidase trimerisation domain MAG.T1.121_01493 479434.Sthe_1558 2.6e-294 1018.1 Thermomicrobia alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 27XHJ@189775,2G5KW@200795,COG0013@1,COG0013@2 NA|NA|NA J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain MAG.T1.121_01494 479434.Sthe_1559 7.9e-30 138.7 Thermomicrobia 3.2.1.78 ko:K01218 ko00051,ko02024,map00051,map02024 R01332 RC00467 ko00000,ko00001,ko01000 GH26 Bacteria 27YCN@189775,2GA9P@200795,COG3299@1,COG3299@2 NA|NA|NA S homolog of phage Mu protein gp47 MAG.T1.121_01495 309801.trd_0729 4.9e-28 131.0 Thermomicrobia yqgF GO:0000966,GO:0000967,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0140097,GO:1901360 ko:K07447 ko00000,ko01000 Bacteria 27YI8@189775,2G74F@200795,COG0816@1,COG0816@2 NA|NA|NA L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA MAG.T1.121_01496 309801.trd_0731 1.6e-24 118.6 Thermomicrobia Bacteria 27YH0@189775,2G736@200795,COG3870@1,COG3870@2 NA|NA|NA S Cyclic-di-AMP receptor MAG.T1.121_01497 479434.Sthe_1563 2.6e-11 76.6 Thermomicrobia VVA0737 ko:K06212 ko00000,ko02000 1.A.16.1.1,1.A.16.1.3 Bacteria 27XRJ@189775,2G5WG@200795,COG0517@1,COG0517@2,COG1994@1,COG1994@2 NA|NA|NA S Belongs to the peptidase M50B family MAG.T1.121_01498 479434.Sthe_0324 9.3e-66 257.3 Thermomicrobia cobB ko:K12410 ko00000,ko01000 Bacteria 27XJ1@189775,2G6QQ@200795,COG0846@1,COG0846@2 NA|NA|NA K Sir2 family MAG.T1.121_01500 882083.SacmaDRAFT_4947 2.3e-37 162.9 Pseudonocardiales 4.2.1.44 ko:K03335 ko00562,ko01100,ko01120,map00562,map01100,map01120 R02782,R05659 RC00782,RC01448 ko00000,ko00001,ko01000 Bacteria 2GJKJ@201174,4E0PV@85010,COG1082@1,COG1082@2 NA|NA|NA G Xylose isomerase-like TIM barrel MAG.T1.121_01501 1410676.JNKL01000028_gene1050 1.5e-10 73.2 Aeromonadales dnaJ GO:0000988,GO:0000989,GO:0003674,GO:0003756,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006457,GO:0006458,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010556,GO:0015035,GO:0015036,GO:0016020,GO:0016032,GO:0016043,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0016989,GO:0019219,GO:0019222,GO:0022607,GO:0031323,GO:0031326,GO:0032991,GO:0034641,GO:0034645,GO:0042026,GO:0043167,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051704,GO:0055114,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0140096,GO:0140110,GO:1901360,GO:1901576,GO:1903506,GO:2001141 ko:K03686 ko00000,ko03029,ko03110 Bacteria 1MVMS@1224,1RNHY@1236,1Y3RP@135624,COG0484@1,COG0484@2 NA|NA|NA O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins MAG.T1.121_01503 309801.trd_1277 1.7e-48 199.5 Thermomicrobia rsmG GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 ko:K03501 ko00000,ko01000,ko03009,ko03036 Bacteria 27YFV@189775,2G6HF@200795,COG0357@1,COG0357@2 NA|NA|NA J Specifically methylates the N7 position of a guanine in 16S rRNA MAG.T1.121_01504 479434.Sthe_1863 4.3e-227 794.3 Thermomicrobia dxs GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0008661,GO:0009058,GO:0009240,GO:0009987,GO:0016740,GO:0016744,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0019842,GO:0030145,GO:0030975,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901363,GO:1901576,GO:1901681 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 Bacteria 27XH0@189775,2G68R@200795,COG1154@1,COG1154@2 NA|NA|NA F Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) MAG.T1.121_01505 479434.Sthe_1386 1.5e-99 369.8 Thermomicrobia Bacteria 27XVF@189775,2G6IF@200795,COG4012@1,COG4012@2 NA|NA|NA S Putative pyruvate format-lyase activating enzyme (DUF1786) MAG.T1.121_01506 1206730.BAGA01000183_gene3174 9.7e-65 253.8 Bacteria pip 3.4.11.5,3.5.1.101 ko:K01259,ko:K18457 ko00330,map00330 R00135 ko00000,ko00001,ko01000,ko01002 Bacteria COG0596@1,COG0596@2 NA|NA|NA S hydrolase activity, acting on ester bonds MAG.T1.121_01507 479434.Sthe_1775 1.4e-82 312.8 Thermomicrobia tptC ko:K02003 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 27YCE@189775,2G6B5@200795,COG1136@1,COG1136@2 NA|NA|NA V ATPases associated with a variety of cellular activities MAG.T1.121_01508 479434.Sthe_1776 1.4e-192 680.2 Thermomicrobia ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 27Z42@189775,2G6CK@200795,COG0577@1,COG0577@2,COG3127@1,COG3127@2 NA|NA|NA V MacB-like periplasmic core domain MAG.T1.121_01509 1121324.CLIT_11c01540 6.2e-32 143.7 Peptostreptococcaceae rbsD GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0009056,GO:0015144,GO:0015145,GO:0015146,GO:0015399,GO:0015405,GO:0015407,GO:0015591,GO:0015608,GO:0015611,GO:0015749,GO:0015750,GO:0015752,GO:0016052,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016866,GO:0016887,GO:0017111,GO:0019303,GO:0019321,GO:0019323,GO:0022804,GO:0022857,GO:0034219,GO:0042623,GO:0042626,GO:0042802,GO:0043211,GO:0043492,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:1901575 5.4.99.62 ko:K06726 ko02010,map02010 R08247 RC02247 ko00000,ko00001,ko01000 iAF1260.b3748,iBWG_1329.BWG_3439,iECDH10B_1368.ECDH10B_3936,iECDH1ME8569_1439.ECDH1ME8569_3636,iECH74115_1262.ECH74115_5184,iECSP_1301.ECSP_4798,iECs_1301.ECs4690,iETEC_1333.ETEC_4039,iEcDH1_1363.EcDH1_4219,iJO1366.b3748,iJR904.b3748,iY75_1357.Y75_RS18330 Bacteria 1VA2V@1239,24MPJ@186801,25RRD@186804,COG1869@1,COG1869@2 NA|NA|NA G Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose MAG.T1.121_01510 326427.Cagg_2810 9.9e-76 290.4 Chloroflexia Bacteria 2G63Y@200795,376X6@32061,COG2421@1,COG2421@2 NA|NA|NA C PFAM Acetamidase Formamidase MAG.T1.121_01511 479434.Sthe_1938 1.1e-102 380.6 Thermomicrobia pyk 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 Bacteria 27XIN@189775,2G5YE@200795,COG0469@1,COG0469@2 NA|NA|NA G Belongs to the pyruvate kinase family MAG.T1.121_01514 765420.OSCT_2952 2.2e-135 490.3 Chloroflexia recQ 3.6.4.12,5.99.1.2 ko:K03169,ko:K03654 ko03018,map03018 ko00000,ko00001,ko01000,ko03032,ko03400 Bacteria 2G6S8@200795,376TB@32061,COG0514@1,COG0514@2 NA|NA|NA L RecQ zinc-binding MAG.T1.121_01515 573370.DMR_15210 1.9e-53 216.1 Deltaproteobacteria Bacteria 1QDCH@1224,28M2G@1,2WWWS@28221,2ZAGX@2,42UN0@68525 NA|NA|NA S Protein of unknown function (DUF3800) MAG.T1.121_01516 926550.CLDAP_30590 1.7e-64 253.1 Chloroflexi menA 2.5.1.74 ko:K02548 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R05617,R06858,R10757 RC02935,RC02936,RC03264 ko00000,ko00001,ko00002,ko01000,ko01006 Bacteria 2G5ZC@200795,COG1575@1,COG1575@2 NA|NA|NA H Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK) MAG.T1.121_01517 479434.Sthe_2942 3.6e-65 255.0 Thermomicrobia menG 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 Bacteria 27YB5@189775,2G6T6@200795,COG0500@1,COG2226@2 NA|NA|NA H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) MAG.T1.121_01518 485913.Krac_9866 3.7e-44 185.7 Bacteria Bacteria COG2141@1,COG2141@2 NA|NA|NA C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases MAG.T1.121_01520 1163409.UUA_15773 2.1e-09 68.9 Xanthomonadales vapC Bacteria 1N9JM@1224,1SYAQ@1236,1XCRX@135614,COG5611@1,COG5611@2 NA|NA|NA S nucleic-acid-binding protein, contains PIN domain MAG.T1.121_01521 1116472.MGMO_61c00180 6.2e-12 78.2 Methylococcales Bacteria 1R3G6@1224,1TGY3@1236,1XGX5@135618,2EAFX@1,334J9@2 NA|NA|NA MAG.T1.121_01522 479434.Sthe_3074 5.2e-17 94.4 Chloroflexi 3.8.1.2 ko:K01560,ko:K07025 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 R05287 RC00697 ko00000,ko00001,ko01000 Bacteria 2G74Q@200795,COG1011@1,COG1011@2 NA|NA|NA S DinB superfamily MAG.T1.121_01524 1219049.SP5_099_00040 2.2e-29 135.6 Sphingomonadales Bacteria 1R391@1224,2C2MK@1,2K95M@204457,2UZNE@28211,2Z81Z@2 NA|NA|NA S Restriction endonuclease NotI MAG.T1.121_01525 766499.C357_17920 1.4e-116 426.4 Alphaproteobacteria dcm 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 Bacteria 1MV9H@1224,2U0FE@28211,COG0270@1,COG0270@2 NA|NA|NA H Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family MAG.T1.121_01526 1449353.JQMQ01000005_gene5718 2e-71 276.6 Actinobacteria yhfX Bacteria 2H81T@201174,COG3457@1,COG3457@2 NA|NA|NA E Alanine racemase, N-terminal domain MAG.T1.121_01527 479434.Sthe_0270 6.2e-81 307.8 Chloroflexi MA20_36475 GO:0000166,GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0003938,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0007623,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0012505,GO:0016192,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030141,GO:0031410,GO:0031974,GO:0031982,GO:0031983,GO:0032940,GO:0034404,GO:0034641,GO:0034654,GO:0034774,GO:0036094,GO:0036230,GO:0042119,GO:0042278,GO:0042451,GO:0042455,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043299,GO:0043312,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046903,GO:0048511,GO:0050896,GO:0051179,GO:0051234,GO:0055086,GO:0055114,GO:0060205,GO:0070013,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097708,GO:0099503,GO:0101002,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659,GO:1904813 1.13.12.16,1.3.1.9 ko:K00459,ko:K02371 ko00061,ko00910,ko01100,ko01212,map00061,map00910,map01100,map01212 M00083 R00025,R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765 RC00052,RC00076,RC02541,RC02759 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 2G8J2@200795,COG2070@1,COG2070@2 NA|NA|NA C PFAM 2-nitropropane dioxygenase NPD MAG.T1.121_01528 1158050.KB895458_gene2440 1.8e-69 269.2 Actinobacteria 2.7.1.89 ko:K07251 ko00730,ko01100,map00730,map01100 R02134 RC00002,RC00017 ko00000,ko00001,ko01000 Bacteria 2I95C@201174,COG0510@1,COG0510@2 NA|NA|NA M Aminoglycoside phosphotransferase MAG.T1.121_01529 1120949.KB903294_gene3997 8.4e-23 113.6 Actinobacteria Bacteria 2FDTP@1,2IP9Y@201174,345UD@2 NA|NA|NA MAG.T1.121_01530 1227488.C477_05777 1.2e-23 116.3 Halobacteria Archaea 2405E@183963,2CIIW@1,2N5XX@2157,2Y4R6@28890 NA|NA|NA MAG.T1.121_01531 1120956.JHZK01000001_gene3521 2.6e-39 169.5 Rhodobiaceae 3.1.3.97 ko:K07053 R00188,R11188 RC00078 ko00000,ko01000 Bacteria 1JQ0Z@119043,1PBDI@1224,2U1HY@28211,COG0613@1,COG0613@2 NA|NA|NA S PHP family MAG.T1.121_01533 479434.Sthe_2508 1.9e-106 393.3 Thermomicrobia gsiB_3 ko:K02035 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 27Y3F@189775,2G9ZZ@200795,COG0747@1,COG0747@2 NA|NA|NA E PFAM extracellular solute-binding protein, family 5 MAG.T1.121_01534 479434.Sthe_2509 5.6e-100 370.9 Thermomicrobia MA20_32335 ko:K02033 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 27XFE@189775,2G6BV@200795,COG0601@1,COG0601@2 NA|NA|NA P PFAM binding-protein-dependent transport systems inner membrane component MAG.T1.121_01535 479434.Sthe_2510 6.8e-82 310.8 Thermomicrobia ko:K02034,ko:K15582 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 27XF3@189775,2G6HB@200795,COG1173@1,COG1173@2 NA|NA|NA P PFAM binding-protein-dependent transport systems inner membrane component MAG.T1.121_01536 1128421.JAGA01000003_gene3010 2e-112 412.9 unclassified Bacteria rsmF GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.176,2.1.1.178 ko:K03500,ko:K11392 ko00000,ko01000,ko03009 Bacteria 2NPE2@2323,COG0144@1,COG0144@2,COG3270@1,COG3270@2 NA|NA|NA J N-terminal domain of 16S rRNA methyltransferase RsmF MAG.T1.121_01539 469383.Cwoe_2232 2.1e-96 359.8 Rubrobacteria 1.1.99.1 ko:K00108 ko00260,ko01100,map00260,map01100 M00555 R01025 RC00087 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJAU@201174,4CRKM@84995,COG2303@1,COG2303@2 NA|NA|NA E GMC oxidoreductase MAG.T1.121_01540 479434.Sthe_3138 1.8e-39 168.7 Bacteria Bacteria 2E7G3@1,331YZ@2 NA|NA|NA MAG.T1.121_01541 479434.Sthe_3137 7e-18 96.7 Bacteria Bacteria 2E1GQ@1,32WV2@2 NA|NA|NA S RES domain MAG.T1.121_01543 309801.trd_0032 1.7e-115 422.5 Thermomicrobia prs GO:0003674,GO:0003824,GO:0004749,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016772,GO:0016778,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2848 Bacteria 27Y35@189775,2G6AF@200795,COG0462@1,COG0462@2 NA|NA|NA F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) MAG.T1.121_01544 1382356.JQMP01000003_gene2109 3e-89 335.9 Thermomicrobia glmU GO:0000270,GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0005975,GO:0005976,GO:0006022,GO:0006023,GO:0006024,GO:0006629,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009252,GO:0009273,GO:0009987,GO:0016051,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0019134,GO:0022610,GO:0030203,GO:0030260,GO:0033692,GO:0034637,GO:0034645,GO:0035635,GO:0040007,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044650,GO:0046872,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0070569,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1903509 2.3.1.157,2.7.7.23 ko:K04042,ko:K11528,ko:K16203 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000,ko01002 3.A.1.5.2 iJN678.glmU,iLJ478.TM1629 Bacteria 27Y0S@189775,2G5VC@200795,COG1207@1,COG1207@2 NA|NA|NA M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain MAG.T1.121_01546 479434.Sthe_1632 1.5e-126 459.5 Thermomicrobia dnaJ ko:K03686 ko00000,ko03029,ko03110 Bacteria 27XY0@189775,2G5NV@200795,COG0484@1,COG0484@2 NA|NA|NA O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins MAG.T1.121_01547 479434.Sthe_1635 2.4e-34 152.9 Thermomicrobia Bacteria 27Y69@189775,2G7F9@200795,COG1397@1,COG1397@2 NA|NA|NA O ADP-ribosylglycohydrolase MAG.T1.121_01548 479434.Sthe_1506 4.7e-171 607.8 Thermomicrobia Bacteria 27XM1@189775,2GB76@200795,COG1574@1,COG1574@2 NA|NA|NA S Amidohydrolase family MAG.T1.121_01549 479434.Sthe_1514 6.6e-77 293.9 Thermomicrobia bCE_4747 Bacteria 27XZY@189775,2G6KN@200795,COG2220@1,COG2220@2 NA|NA|NA S Beta-lactamase superfamily domain MAG.T1.121_01550 479434.Sthe_1516 1.2e-18 99.4 Thermomicrobia Bacteria 27YJN@189775,2A4R3@1,2GBAR@200795,30TCF@2 NA|NA|NA MAG.T1.121_01551 309801.trd_0910 1.9e-85 322.4 Chloroflexi Bacteria 2G8K5@200795,COG1028@1,COG1028@2 NA|NA|NA IQ PFAM short-chain dehydrogenase reductase SDR MAG.T1.121_01552 1510531.JQJJ01000013_gene190 3.5e-99 368.6 Alphaproteobacteria 1.5.3.1 ko:K00303 ko00260,ko01100,map00260,map01100 R00610 RC00060,RC00557 ko00000,ko00001,ko01000 Bacteria 1MU7M@1224,2TV9B@28211,COG0665@1,COG0665@2 NA|NA|NA E FAD dependent oxidoreductase MAG.T1.121_01553 479434.Sthe_1893 2.8e-96 358.6 Thermomicrobia gsiD_8 ko:K02034,ko:K15582 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 27YRU@189775,2GAH3@200795,COG1173@1,COG1173@2 NA|NA|NA EP N-terminal TM domain of oligopeptide transport permease C MAG.T1.121_01554 1382356.JQMP01000003_gene1956 1.2e-105 389.8 Thermomicrobia gsiC_11 ko:K02033,ko:K13890 ko02010,ko02024,map02010,map02024 M00239,M00348 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.11 Bacteria 27YS2@189775,2GA2G@200795,COG0601@1,COG0601@2 NA|NA|NA EP Binding-protein-dependent transport system inner membrane component MAG.T1.121_01555 479434.Sthe_1891 7.1e-151 540.8 Thermomicrobia ko:K02035 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 27YXD@189775,2G9YP@200795,COG0747@1,COG0747@2 NA|NA|NA E Bacterial extracellular solute-binding proteins, family 5 Middle MAG.T1.121_01558 1128421.JAGA01000004_gene2597 1.4e-76 293.9 unclassified Bacteria ko:K08482 ko00000 Bacteria 2NQUV@2323,COG0467@1,COG0467@2 NA|NA|NA T KaiC MAG.T1.121_01559 321332.CYB_1343 5.8e-09 68.2 Synechococcus ycf29 ko:K02485,ko:K07684 ko02020,map02020 M00471 ko00000,ko00001,ko00002,ko02022 Bacteria 1G1TZ@1117,1GYRN@1129,COG2197@1,COG2197@2 NA|NA|NA K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain MAG.T1.121_01560 479434.Sthe_1858 1.5e-130 473.0 Thermomicrobia lhgO 1.1.99.2 ko:K00109,ko:K15736 ko00650,map00650 R03534 RC00031 ko00000,ko00001,ko01000 Bacteria 27XHD@189775,2G67E@200795,COG0579@1,COG0579@2 NA|NA|NA C FAD dependent oxidoreductase MAG.T1.121_01561 1122182.KB903814_gene3569 9.7e-12 75.9 Micromonosporales Bacteria 2CA4F@1,2GRQ2@201174,33DCB@2,4DG72@85008 NA|NA|NA MAG.T1.121_01562 1122609.AUGT01000017_gene978 5.4e-13 80.1 Actinobacteria Bacteria 2CA4F@1,2GRQ2@201174,33DCB@2 NA|NA|NA MAG.T1.121_01565 1382356.JQMP01000003_gene2449 2.2e-11 77.4 Thermomicrobia GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.7.2.1 ko:K00368,ko:K18683 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 Bacteria 27YMB@189775,2GA6H@200795,COG4454@1,COG4454@2 NA|NA|NA P Copper binding proteins, plastocyanin/azurin family MAG.T1.121_01566 644966.Tmar_0323 2.1e-36 159.1 Clostridia 1.10.9.1 ko:K02636,ko:K03886 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00151,M00162 R03817,R08409 RC01002 ko00000,ko00001,ko00002,ko00194,ko01000 Bacteria 1VM4K@1239,24X5X@186801,COG0723@1,COG0723@2 NA|NA|NA C PFAM Rieske 2Fe-2S domain MAG.T1.121_01567 867903.ThesuDRAFT_02243 6e-42 177.9 Clostridia Bacteria 1USWS@1239,2501X@186801,COG1290@1,COG1290@2 NA|NA|NA C Cytochrome b(C-terminal)/b6/petD MAG.T1.121_01568 485913.Krac_6667 3.4e-84 318.2 Chloroflexi Bacteria 2G8QQ@200795,COG1290@1,COG1290@2 NA|NA|NA C Cytochrome b(N-terminal)/b6/petB MAG.T1.121_01570 479434.Sthe_1579 7.1e-41 173.3 Thermomicrobia 3.5.99.10 ko:K09022 R11098,R11099 RC03275,RC03354 ko00000,ko01000 Bacteria 27YDZ@189775,2G6XT@200795,COG0251@1,COG0251@2 NA|NA|NA J Endoribonuclease L-PSP MAG.T1.121_01571 1382356.JQMP01000004_gene447 2.3e-146 525.4 Thermomicrobia Bacteria 27YWW@189775,2G69R@200795,COG4948@1,COG4948@2 NA|NA|NA M Mandelate racemase / muconate lactonizing enzyme, C-terminal domain MAG.T1.121_01572 479434.Sthe_1577 1.6e-119 437.2 Thermomicrobia Bacteria 27XP7@189775,2G67R@200795,COG2720@1,COG2720@2 NA|NA|NA V VanW like protein MAG.T1.121_01575 262724.TT_C1628 3.6e-84 318.5 Deinococcus-Thermus sugA GO:0008150,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051704 ko:K02025,ko:K10237,ko:K15771,ko:K17316 ko02010,map02010 M00204,M00207,M00491,M00605 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.17,3.A.1.1.2,3.A.1.1.24,3.A.1.1.30 iNJ661.Rv1236 Bacteria 1WI9Z@1297,COG1175@1,COG1175@2 NA|NA|NA G PFAM binding-protein-dependent transport systems inner membrane component MAG.T1.121_01576 604331.AUHY01000022_gene1518 1.4e-97 363.6 Deinococcus-Thermus malE ko:K02027,ko:K10236 ko02010,map02010 M00204,M00207 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.17 Bacteria 1WI9Y@1297,COG1653@1,COG1653@2 NA|NA|NA G ABC-type sugar transport system periplasmic component MAG.T1.121_01577 1122917.KB899661_gene1060 2.8e-157 562.0 Paenibacillaceae xylBch 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQ1I@1239,26XB8@186822,4HBRJ@91061,COG1070@1,COG1070@2 NA|NA|NA G FGGY family of carbohydrate kinases, N-terminal domain MAG.T1.121_01578 290400.Jann_2112 1.6e-69 269.6 Alphaproteobacteria ko:K06971 ko00000 Bacteria 1Q83B@1224,2U2I9@28211,COG0434@1,COG0434@2 NA|NA|NA S TIM-barrel enzyme MAG.T1.121_01579 1454007.JAUG01000087_gene3940 9.1e-16 90.1 Sphingobacteriia ko:K07005 ko00000 Bacteria 1ITPB@117747,4NQFR@976,COG3467@1,COG3467@2 NA|NA|NA S SPTR Pyridoxamine 5'-phosphate oxidase-related FMN-binding protein MAG.T1.121_01580 378806.STAUR_8383 1.7e-65 256.5 Myxococcales Bacteria 1MX9E@1224,2WVK9@28221,2YV9B@29,42QKD@68525,COG2041@1,COG2041@2 NA|NA|NA S Oxidoreductase molybdopterin binding domain MAG.T1.121_01581 644282.Deba_0738 7.2e-44 184.5 Deltaproteobacteria prmC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464 2.1.1.297 ko:K02493 R10806 RC00003,RC03279 ko00000,ko01000,ko03012 Bacteria 1MXCQ@1224,2WNH0@28221,42PKA@68525,COG2890@1,COG2890@2 NA|NA|NA J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif MAG.T1.121_01582 479434.Sthe_1900 2.2e-127 462.2 Thermomicrobia prfA GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02835,ko:K15034 ko00000,ko03012 Bacteria 27XG3@189775,2G5UD@200795,COG0216@1,COG0216@2 NA|NA|NA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA MAG.T1.121_01583 1128421.JAGA01000002_gene1053 1.5e-26 126.3 unclassified Bacteria ligT GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008104,GO:0008150,GO:0009966,GO:0010646,GO:0010738,GO:0023051,GO:0033036,GO:0034237,GO:0044424,GO:0044444,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051018,GO:0051179,GO:0065007,GO:1902531 3.1.4.58 ko:K01975 ko00000,ko01000,ko03016 Bacteria 2NPRT@2323,COG1514@1,COG1514@2 NA|NA|NA J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester MAG.T1.121_01584 479434.Sthe_1887 9.2e-84 317.0 Thermomicrobia pheA 4.2.1.51 ko:K04518 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024 R00691,R01373 RC00360 ko00000,ko00001,ko00002,ko01000 Bacteria 27XFH@189775,2G6AP@200795,COG0077@1,COG0077@2 NA|NA|NA E Prephenate dehydratase MAG.T1.121_01585 479434.Sthe_1908 2.9e-20 105.9 Thermomicrobia mqnD ko:K07083,ko:K11785 ko00130,ko01110,map00130,map01110 R08589 RC02330 ko00000,ko00001,ko01000 Bacteria 27Z9M@189775,2GA51@200795,COG2107@1,COG2107@2 NA|NA|NA S Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) MAG.T1.121_01586 316067.Geob_2530 1.4e-102 379.8 Desulfuromonadales 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUBE@1224,2WJ7R@28221,42N1R@68525,43U5M@69541,COG0031@1,COG0031@2 NA|NA|NA H Pyridoxal-phosphate dependent enzyme MAG.T1.121_01587 309801.trd_1708 1.5e-60 239.6 Thermomicrobia moaD GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.8.1.12 ko:K03635,ko:K03636,ko:K21142 ko00790,ko01100,ko04122,map00790,map01100,map04122 R09395 RC02507 ko00000,ko00001,ko01000 Bacteria 27Y6P@189775,2G6YQ@200795,COG0314@1,COG0314@2,COG1977@1,COG1977@2 NA|NA|NA H MoaE protein MAG.T1.121_01588 1157490.EL26_23155 8.2e-139 500.4 Alicyclobacillaceae pcaF 2.3.1.16,2.3.1.174,2.3.1.223,2.3.1.9 ko:K00626,ko:K00632,ko:K02615 ko00071,ko00072,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00360,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00087,M00088,M00095,M00113,M00373,M00374,M00375 R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095,R09839 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955,RC03003 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1TP07@1239,277YV@186823,4H9RJ@91061,COG0183@1,COG0183@2 NA|NA|NA I Belongs to the thiolase family MAG.T1.121_01589 479434.Sthe_1008 1.9e-45 189.9 Chloroflexi ko:K18566 ko00332,ko01130,map00332,map01130 R10745,R10746 RC00004,RC00096 ko00000,ko00001,ko01000 Bacteria 2G6N6@200795,COG0454@1,COG0456@2 NA|NA|NA K PFAM GCN5-related N-acetyltransferase MAG.T1.121_01590 479434.Sthe_0740 2.2e-126 459.1 Thermomicrobia moeA 2.10.1.1,2.7.7.75 ko:K03750,ko:K15376 ko00790,ko01100,ko04727,map00790,map01100,map04727 R09726,R09735 RC00002,RC03462 ko00000,ko00001,ko01000 Bacteria 27Y3T@189775,2G6AK@200795,COG0303@1,COG0303@2 NA|NA|NA H MoeA N-terminal region (domain I and II) MAG.T1.121_01591 479434.Sthe_0734 3.9e-259 901.0 Thermomicrobia relA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 iSFV_1184.SFV_2673 Bacteria 27XXG@189775,2G67Y@200795,COG0317@1,COG0317@2 NA|NA|NA KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance MAG.T1.121_01592 479434.Sthe_0733 4.6e-44 185.3 Thermomicrobia frk2 2.7.1.4 ko:K00847 ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100 R00760,R00867,R03920 RC00002,RC00017 ko00000,ko00001,ko01000 Bacteria 27YGK@189775,2G7YB@200795,COG0524@1,COG0524@2 NA|NA|NA G pfkB family carbohydrate kinase MAG.T1.121_01593 13035.Dacsa_0732 1.5e-51 209.9 Cyanobacteria lgt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008961,GO:0009058,GO:0009059,GO:0009249,GO:0009898,GO:0009987,GO:0010467,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051604,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0140096,GO:1901564,GO:1901566,GO:1901576 2.1.1.199 ko:K03438,ko:K13292 ko00000,ko01000,ko03009 Bacteria 1G0H2@1117,COG0682@1,COG0682@2 NA|NA|NA M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins MAG.T1.121_01594 867903.ThesuDRAFT_01821 1.6e-42 180.6 Clostridia argH2 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1U4V0@1239,24EEH@186801,COG0165@1,COG0165@2 NA|NA|NA E Argininosuccinate lyase C-terminal MAG.T1.121_01595 479434.Sthe_1564 9.6e-138 496.9 Thermomicrobia hflX GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006464,GO:0006468,GO:0006518,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018105,GO:0018193,GO:0018209,GO:0019001,GO:0019222,GO:0019538,GO:0019843,GO:0022411,GO:0030554,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032790,GO:0032984,GO:0032988,GO:0034248,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0043021,GO:0043022,GO:0043023,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:2000112 ko:K03665 ko00000,ko03009 Bacteria 27XK0@189775,2G634@200795,COG2262@1,COG2262@2 NA|NA|NA S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis MAG.T1.121_01596 479434.Sthe_1566 1.5e-80 306.6 Thermomicrobia purM GO:0003674,GO:0003824,GO:0004641,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.1,6.3.4.13 ko:K01933,ko:K11788 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144,R04208 RC00090,RC00166,RC01100 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1844,iECSF_1327.ECSF_2340 Bacteria 27Y07@189775,2G5YZ@200795,COG0150@1,COG0150@2 NA|NA|NA F AIR synthase related protein, C-terminal domain MAG.T1.121_01597 309801.trd_0864 3.8e-38 164.9 Thermomicrobia ko:K06883 ko00000 Bacteria 27XH2@189775,2G6A7@200795,COG1100@1,COG1100@2 NA|NA|NA S ADP-ribosylation factor family MAG.T1.121_01598 1429916.X566_21220 3.3e-07 61.2 Proteobacteria Bacteria 1R2VK@1224,3220G@2,arCOG10157@1 NA|NA|NA S EthD domain MAG.T1.121_01599 479434.Sthe_0255 4.5e-62 245.0 Chloroflexi fadB3 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 Bacteria 2G6EB@200795,COG1250@1,COG1250@2 NA|NA|NA C 3-hydroxyacyl-CoA dehydrogenase domain protein MAG.T1.121_01601 1209984.BN978_03698 3.2e-58 231.9 Mycobacteriaceae ko:K05799 ko00000,ko03000 Bacteria 236Z8@1762,2I90D@201174,COG2186@1,COG2186@2 NA|NA|NA K GntR family MAG.T1.121_01602 1408254.T458_10290 7.2e-41 174.5 Paenibacillaceae 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 Bacteria 1TPJS@1239,272FW@186822,4HA59@91061,COG1250@1,COG1250@2 NA|NA|NA I NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus MAG.T1.121_01604 1123242.JH636435_gene2176 4e-75 288.1 Bacteria 4.1.2.20,4.1.2.52 ko:K01630,ko:K02510 ko00053,ko00350,ko01120,map00053,map00350,map01120 R01645,R01647,R02754,R03277 RC00307,RC00435,RC00572,RC00574,RC03057 ko00000,ko00001,ko01000 Bacteria COG3836@1,COG3836@2 NA|NA|NA G 2-keto-3-deoxy-L-rhamnonate aldolase activity MAG.T1.121_01605 1120950.KB892757_gene6417 2.2e-92 345.9 Propionibacteriales 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GJGA@201174,4DPA7@85009,COG0111@1,COG0111@2 NA|NA|NA E D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain MAG.T1.121_01606 1120950.KB892757_gene6419 9.6e-18 96.7 Bacteria 5.1.99.1 ko:K05606 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R02765,R09979 RC00780,RC02739 ko00000,ko00001,ko00002,ko01000 Bacteria COG0346@1,COG0346@2 NA|NA|NA E lactoylglutathione lyase activity MAG.T1.121_01607 621372.ACIH01000032_gene602 7e-119 434.5 Paenibacillaceae rbsA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008144,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015146,GO:0015399,GO:0015405,GO:0015407,GO:0015591,GO:0015608,GO:0015611,GO:0015749,GO:0015750,GO:0015752,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0031224,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034219,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043190,GO:0043211,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901265,GO:1901363,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.17 ko:K10441,ko:K10542 ko02010,map02010 M00212,M00214 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.3 iEC55989_1330.EC55989_4224,iECSE_1348.ECSE_4039,iECW_1372.ECW_m4052,iEcE24377_1341.EcE24377A_4265,iWFL_1372.ECW_m4052,iYL1228.KPN_04154 Bacteria 1TP6I@1239,26SVT@186822,4H9VK@91061,COG1129@1,COG1129@2 NA|NA|NA G import. Responsible for energy coupling to the transport system MAG.T1.121_01608 1304865.JAGF01000001_gene415 3.4e-32 146.0 Actinobacteria ko:K02058,ko:K10439 ko02010,ko02030,map02010,map02030 M00212,M00221 ko00000,ko00001,ko00002,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 Bacteria 2IBAQ@201174,COG1879@1,COG1879@2 NA|NA|NA G Periplasmic binding protein domain MAG.T1.121_01609 311403.Arad_7212 1.1e-56 227.3 Proteobacteria ko:K02057,ko:K10440 ko02010,map02010 M00212,M00221 ko00000,ko00001,ko00002,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 Bacteria 1QICJ@1224,COG1172@1,COG1172@2 NA|NA|NA G Belongs to the binding-protein-dependent transport system permease family MAG.T1.121_01610 1194165.CAJF01000015_gene1449 3e-51 208.8 Actinobacteria Bacteria 2GJU1@201174,COG1028@1,COG1028@2 NA|NA|NA IQ Short-chain dehydrogenase reductase sdr MAG.T1.121_01611 298386.PBPRA1313 1.8e-12 80.9 Vibrionales Bacteria 1N3D9@1224,1SAIK@1236,1XYM9@135623,28M8W@1,2ZAMX@2 NA|NA|NA S Domain of unknown function (DUF4062) MAG.T1.121_01612 1382356.JQMP01000004_gene503 1.8e-58 233.4 Thermomicrobia enhA_2 Bacteria 27XVB@189775,2G6ZY@200795,COG1376@1,COG1376@2,COG5479@1,COG5479@2 NA|NA|NA M L,D-transpeptidase catalytic domain MAG.T1.121_01614 309801.trd_1776 1.7e-81 310.8 Thermomicrobia cadA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.3,3.6.3.5 ko:K01534,ko:K12951,ko:K21887 ko00000,ko01000 3.A.3,3.A.3.6 Bacteria 27YTH@189775,2G5QF@200795,COG2217@1,COG2217@2 NA|NA|NA P E1-E2 ATPase MAG.T1.121_01615 1382356.JQMP01000001_gene959 9.2e-107 393.7 Thermomicrobia nikV 3.6.3.24 ko:K02031,ko:K02032,ko:K10823,ko:K10824 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439,M00440 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 27Z3W@189775,2GARG@200795,COG4608@1,COG4608@2 NA|NA|NA P Oligopeptide/dipeptide transporter, C-terminal region MAG.T1.121_01616 309801.trd_1954 7.9e-103 380.6 Thermomicrobia oppD ko:K02031,ko:K02032,ko:K15583 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 27Z2B@189775,2GBE3@200795,COG0444@1,COG0444@2 NA|NA|NA P Oligopeptide/dipeptide transporter, C-terminal region MAG.T1.121_01617 1382356.JQMP01000001_gene963 3.6e-67 261.9 Thermomicrobia ko:K02034 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 27YUP@189775,2G8EC@200795,COG1173@1,COG1173@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component MAG.T1.121_01618 309801.trd_1951 1.2e-100 373.2 Thermomicrobia ko:K02033 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 27YWJ@189775,2GAQS@200795,COG0601@1,COG0601@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component MAG.T1.121_01619 1382356.JQMP01000001_gene961 9.2e-102 377.9 Thermomicrobia ko:K02035 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 27YY9@189775,2GASZ@200795,COG0747@1,COG0747@2 NA|NA|NA E Bacterial extracellular solute-binding proteins, family 5 Middle MAG.T1.121_01622 743718.Isova_2672 2.6e-27 129.0 Promicromonosporaceae cofC GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0043814,GO:0044237,GO:0044249,GO:0051186,GO:0051188,GO:0070568 2.7.7.68 ko:K14941 ko00680,ko01120,map00680,map01120 M00378 R09397 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 2I0MF@201174,4F4S3@85017,COG1920@1,COG1920@2 NA|NA|NA S GTP binding MAG.T1.121_01623 479434.Sthe_2500 9.5e-85 320.1 Thermomicrobia fbiB GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0044237,GO:0044249,GO:0044464,GO:0051186,GO:0051188,GO:0071944 6.3.2.31,6.3.2.34 ko:K12234 ko00680,ko01120,map00680,map01120 M00378 R09399,R09400 RC00064,RC00090,RC00141 ko00000,ko00001,ko00002,ko01000 Bacteria 27XFS@189775,2G5TU@200795,COG1478@1,COG1478@2 NA|NA|NA S F420-0:Gamma-glutamyl ligase MAG.T1.121_01624 42256.RradSPS_2686 2.1e-145 521.9 Rubrobacteria Bacteria 2GM94@201174,4CQ61@84995,COG2141@1,COG2141@2 NA|NA|NA C F420-dependent oxidoreductase, G6PDH family MAG.T1.121_01625 743722.Sph21_4397 1.2e-28 134.4 Sphingobacteriia Bacteria 1IW7U@117747,4NWN8@976,COG3209@1,COG3209@2 NA|NA|NA M F-box associated region MAG.T1.121_01626 504832.OCAR_7514 2e-63 249.6 Bradyrhizobiaceae ko:K02033 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 1MU8Z@1224,2TT48@28211,3JSZX@41294,COG0601@1,COG0601@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component MAG.T1.121_01627 1105031.HMPREF1141_3435 2.4e-55 222.6 Clostridiaceae ko:K02034 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 1TP4R@1239,2489T@186801,36E1E@31979,COG1173@1,COG1173@2 NA|NA|NA EP PFAM binding-protein-dependent transport systems inner membrane component MAG.T1.121_01628 1123237.Salmuc_03148 1.1e-55 224.6 Alphaproteobacteria ko:K02035 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 1MUZH@1224,2TQQH@28211,COG0747@1,COG0747@2 NA|NA|NA E ABC-type dipeptide transport system periplasmic component MAG.T1.121_01629 525904.Tter_1856 8.8e-63 246.9 unclassified Bacteria Bacteria 2NR3U@2323,COG0778@1,COG0778@2,COG3576@1,COG3576@2 NA|NA|NA C Nitroreductase family MAG.T1.121_01630 1120958.AULD01000006_gene527 1e-53 217.2 Microbacteriaceae Bacteria 2GK20@201174,4FNBP@85023,COG1028@1,COG1028@2 NA|NA|NA IQ KR domain MAG.T1.121_01631 479434.Sthe_3194 1.9e-30 138.7 Bacteria kdgF Bacteria COG1917@1,COG1917@2 NA|NA|NA L Cupin 2, conserved barrel domain protein MAG.T1.121_01634 742733.HMPREF9469_00695 1.6e-35 156.4 Lachnoclostridium 4.1.2.17 ko:K01628 ko00051,ko01120,map00051,map01120 R02262 RC00603,RC00604 ko00000,ko00001,ko01000 Bacteria 1TPDV@1239,220S6@1506553,248KI@186801,COG0235@1,COG0235@2 NA|NA|NA G COG COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases MAG.T1.121_01635 42256.RradSPS_1697 5.6e-276 957.2 Rubrobacteria copA 3.6.3.4,3.6.3.54 ko:K01533,ko:K17686 ko01524,ko04016,map01524,map04016 R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 Bacteria 2GIRF@201174,4CPA7@84995,COG2217@1,COG2217@2 NA|NA|NA P heavy metal translocating P-type ATPase MAG.T1.121_01636 485913.Krac_9884 2.1e-08 64.7 Bacteria ko:K07213,ko:K08364 ko04978,map04978 ko00000,ko00001,ko02000 1.A.72.1 Bacteria COG2608@1,COG2608@2 NA|NA|NA P mercury ion transmembrane transporter activity MAG.T1.121_01637 309801.trd_1415 1.6e-19 102.4 Thermomicrobia csoR ko:K21600 ko00000,ko03000 Bacteria 27YK9@189775,2G7H9@200795,COG1937@1,COG1937@2 NA|NA|NA S Metal-sensitive transcriptional repressor MAG.T1.121_01638 591159.ACEZ01000107_gene5038 3.8e-87 328.9 Actinobacteria 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 Bacteria 2GNCR@201174,COG1070@1,COG1070@2 NA|NA|NA G Belongs to the FGGY kinase family MAG.T1.121_01639 479434.Sthe_1866 3.9e-23 114.0 Thermomicrobia rpsP GO:0000028,GO:0000217,GO:0000400,GO:0003674,GO:0003676,GO:0003677,GO:0003735,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006259,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016787,GO:0016788,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02959 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011,ko03029 Bacteria 27YHM@189775,2G7A3@200795,COG0228@1,COG0228@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bS16 family MAG.T1.121_01640 479434.Sthe_1867 1.9e-13 81.6 Thermomicrobia CP_0960 GO:0008150,GO:0040007 ko:K06960 ko00000 Bacteria 27YME@189775,2G9VQ@200795,COG1837@1,COG1837@2 NA|NA|NA S KH domain MAG.T1.121_01641 479434.Sthe_1868 2.3e-30 139.0 Thermomicrobia rimM GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 ko:K02860 ko00000,ko03009 Bacteria 27YEY@189775,2G707@200795,COG0806@1,COG0806@2 NA|NA|NA J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes MAG.T1.121_01642 1123250.KB908386_gene450 6.5e-17 94.7 Negativicutes mtnN 3.2.2.9 ko:K01243 ko00270,ko01100,ko01230,map00270,map01100,map01230 M00034,M00609 R00194,R01401 RC00063,RC00318 ko00000,ko00001,ko00002,ko01000 Bacteria 1TSB7@1239,4H55Z@909932,COG0775@1,COG0775@2 NA|NA|NA F Phosphorylase superfamily MAG.T1.121_01644 479434.Sthe_0068 5e-55 221.5 Thermomicrobia ko:K07090 ko00000 Bacteria 27YU2@189775,2G6ZH@200795,COG0730@1,COG0730@2 NA|NA|NA S Sulfite exporter TauE/SafE MAG.T1.121_01645 309801.trd_0193 1e-41 177.6 Thermomicrobia ko:K13735 ko05100,map05100 ko00000,ko00001 Bacteria 27XNP@189775,2GBGP@200795,COG2373@1,COG2373@2 NA|NA|NA M Prenyltransferase and squalene oxidase repeat MAG.T1.121_01646 309801.trd_0192 2.1e-25 122.9 Thermomicrobia Bacteria 27YE7@189775,2G7AD@200795,COG1657@1,COG1657@2 NA|NA|NA I PFAM Prenyltransferase squalene oxidase MAG.T1.121_01647 479434.Sthe_0927 1.9e-37 163.3 Thermomicrobia ecfT GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015238,GO:0015711,GO:0015893,GO:0016020,GO:0022857,GO:0032217,GO:0032218,GO:0034220,GO:0035461,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051180,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0090482,GO:0098656 ko:K02008,ko:K16783,ko:K16785 ko02010,map02010 M00245,M00246,M00581,M00582 ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23,3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 Bacteria 27YHQ@189775,2G71W@200795,COG0619@1,COG0619@2 NA|NA|NA P Cobalt transport protein MAG.T1.121_01648 1128421.JAGA01000002_gene230 1.1e-125 457.2 unclassified Bacteria ko:K16786,ko:K16787 ko02010,map02010 M00582 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 Bacteria 2NS56@2323,COG1129@1,COG1129@2 NA|NA|NA G AAA domain, putative AbiEii toxin, Type IV TA system MAG.T1.121_01649 383372.Rcas_1067 3.6e-61 241.5 Chloroflexia pdxH 1.4.3.5 ko:K00275 ko00750,ko01100,ko01120,map00750,map01100,map01120 M00124 R00277,R00278,R01710,R01711 RC00048,RC00116 ko00000,ko00001,ko00002,ko01000 iJN678.pdxH Bacteria 2G8DA@200795,376ZA@32061,COG0259@1,COG0259@2 NA|NA|NA H Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) MAG.T1.121_01650 926550.CLDAP_16730 1.3e-35 156.4 Bacteria 5.3.1.27 ko:K08094 ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230 M00345,M00580 R05339,R09780 RC00377 ko00000,ko00001,ko00002,ko01000 Bacteria COG0794@1,COG0794@2 NA|NA|NA M arabinose-5-phosphate isomerase activity MAG.T1.121_01652 309801.trd_1184 2.7e-203 714.9 Thermomicrobia guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 iJN746.PP_1032,iLJ478.TM1820,iSF_1195.SF2553,iSFxv_1172.SFxv_2808,iS_1188.S2725,iYL1228.KPN_02833 Bacteria 27XQ3@189775,2G5WB@200795,COG0518@1,COG0518@2,COG0519@1,COG0519@2 NA|NA|NA F Catalyzes the synthesis of GMP from XMP MAG.T1.121_01653 66692.ABC3097 2.5e-27 130.6 Bacillus atl 3.2.1.96,3.4.17.14,3.5.1.28,6.1.1.12 ko:K01227,ko:K01876,ko:K07260,ko:K11060,ko:K13714,ko:K21472 ko00511,ko00550,ko00970,ko01100,ko01502,ko02020,map00511,map00550,map00970,map01100,map01502,map02020 M00359,M00360,M00651 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01002,ko01007,ko01011,ko01504,ko02042,ko03016,ko03029 GH73 Bacteria 1UI28@1239,1ZC2V@1386,4ISBN@91061,COG3103@1,COG3103@2,COG3807@1,COG3807@2,COG4193@1,COG4193@2 NA|NA|NA G Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase MAG.T1.121_01654 710685.MycrhN_0078 5.7e-98 364.0 Mycobacteriaceae Bacteria 233Z6@1762,2GW8A@201174,COG1028@1,COG1028@2 NA|NA|NA IQ Enoyl-(Acyl carrier protein) reductase MAG.T1.121_01655 479434.Sthe_2142 1.1e-70 273.1 Thermomicrobia rex GO:0003674,GO:0005488,GO:0005515,GO:0042802 ko:K01926 ko00000,ko03000 Bacteria 27XIR@189775,2G6EJ@200795,COG2344@1,COG2344@2 NA|NA|NA K Modulates transcription in response to changes in cellular NADH NAD( ) redox state MAG.T1.121_01657 1380390.JIAT01000012_gene2999 2e-86 327.8 Rubrobacteria wbxA Bacteria 2HENX@201174,4CRKC@84995,COG0438@1,COG0438@2,COG0463@1,COG0463@2,COG1216@1,COG1216@2 NA|NA|NA M Glycosyl transferases group 1 MAG.T1.121_01658 1122609.AUGT01000024_gene384 5.7e-19 102.8 Bacteria 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 R00578 RC00010 ko00000,ko00001,ko01000,ko01002 Bacteria COG0367@1,COG0367@2 NA|NA|NA E asparagine synthase MAG.T1.121_01659 1380390.JIAT01000012_gene2999 3e-92 347.1 Rubrobacteria wbxA Bacteria 2HENX@201174,4CRKC@84995,COG0438@1,COG0438@2,COG0463@1,COG0463@2,COG1216@1,COG1216@2 NA|NA|NA M Glycosyl transferases group 1 MAG.T1.121_01660 926550.CLDAP_35320 8.1e-152 543.9 Chloroflexi rbsA 3.6.3.17 ko:K10441 ko02010,map02010 M00212 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 Bacteria 2G649@200795,COG1129@1,COG1129@2 NA|NA|NA P Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system MAG.T1.121_01661 926550.CLDAP_35310 6.9e-99 367.5 Chloroflexi ko:K10440,ko:K17209 ko02010,map02010 M00212,M00592 ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.21 Bacteria 2G6A4@200795,COG1172@1,COG1172@2 NA|NA|NA G Branched-chain amino acid transport system / permease component MAG.T1.121_01662 1122132.AQYH01000010_gene4206 1.1e-75 290.4 Rhizobiaceae rbsB ko:K10439,ko:K17208 ko02010,ko02030,map02010,map02030 M00212,M00592 ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.21 Bacteria 1NRXG@1224,2TV27@28211,4BBI6@82115,COG1879@1,COG1879@2 NA|NA|NA G Periplasmic binding protein-like domain MAG.T1.121_01663 1382304.JNIL01000001_gene1685 5.7e-124 451.1 Alicyclobacillaceae chrA ko:K07240 ko00000,ko02000 2.A.51.1 Bacteria 1TSKA@1239,279HT@186823,4HBB1@91061,COG2059@1,COG2059@2 NA|NA|NA P Chromate transporter MAG.T1.121_01664 1343740.M271_40275 1.5e-81 309.7 Actinobacteria 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJDB@201174,COG0329@1,COG0329@2 NA|NA|NA EM Belongs to the DapA family MAG.T1.121_01665 926550.CLDAP_24430 8.3e-53 214.2 Bacteria ywfM ko:K03298 ko00000,ko02000 2.A.7.3 Bacteria COG0697@1,COG0697@2 NA|NA|NA EG spore germination MAG.T1.121_01666 1382306.JNIM01000001_gene3339 6.6e-206 723.8 Chloroflexi ilvD GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 Bacteria 2G67Z@200795,COG0129@1,COG0129@2 NA|NA|NA E Belongs to the IlvD Edd family MAG.T1.121_01668 479434.Sthe_2632 3.7e-29 134.0 Thermomicrobia ko:K06885 ko00000 Bacteria 27XHR@189775,2G8B8@200795,COG1078@1,COG1078@2 NA|NA|NA S Metal dependent phosphohydrolases with conserved 'HD' motif. MAG.T1.121_01669 309801.trd_0089 5.8e-11 73.9 Thermomicrobia rpmB GO:0003674,GO:0003735,GO:0005198 ko:K02902 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 27Z9I@189775,2G9W5@200795,COG0227@1,COG0227@2 NA|NA|NA J Ribosomal L28 family MAG.T1.121_01670 479434.Sthe_0461 1.7e-117 429.5 Thermomicrobia queG GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 ko:K18979 ko00000,ko01000,ko03016 Bacteria 27XIW@189775,2G6A0@200795,COG1600@1,COG1600@2 NA|NA|NA C Domain of unknown function (DUF1730) MAG.T1.121_01671 479434.Sthe_0462 6.2e-49 201.4 Thermomicrobia adoK GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004001,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005975,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019200,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032552,GO:0032553,GO:0032554,GO:0032555,GO:0032559,GO:0032560,GO:0032561,GO:0032567,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046390,GO:0046483,GO:0046835,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.15,2.7.1.20 ko:K00852,ko:K00856 ko00030,ko00230,ko01100,map00030,map00230,map01100 R00185,R01051,R02750 RC00002,RC00017 ko00000,ko00001,ko01000 iAF987.Gmet_2683 Bacteria 27Y74@189775,2G7CJ@200795,COG0524@1,COG0524@2 NA|NA|NA G belongs to the carbohydrate kinase PfkB family MAG.T1.121_01672 1463879.JOHP01000056_gene3479 1.4e-15 90.1 Actinobacteria betI3 Bacteria 2IIK3@201174,COG1309@1,COG1309@2 NA|NA|NA K regulatory protein, tetR MAG.T1.121_01673 326427.Cagg_0709 3.6e-99 368.2 Chloroflexia 1.14.14.5 ko:K04091 ko00920,map00920 R07210,R10206 RC01779,RC02556 ko00000,ko00001,ko01000 Bacteria 2G87P@200795,377SH@32061,COG2141@1,COG2141@2 NA|NA|NA C Luciferase-like monooxygenase MAG.T1.121_01674 309801.trd_A0006 1.9e-34 153.7 Thermomicrobia ko:K08218,ko:K08223 ko01501,map01501 M00628 ko00000,ko00001,ko00002,ko02000 2.A.1.25,2.A.1.35 Bacteria 27Y8E@189775,2GA6Q@200795,COG2211@1,COG2211@2 NA|NA|NA G Major facilitator Superfamily MAG.T1.121_01675 479434.Sthe_2742 1.4e-42 179.5 Thermomicrobia hit GO:0003674,GO:0003824,GO:0003877,GO:0004551,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008796,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009987,GO:0015959,GO:0015961,GO:0015965,GO:0015967,GO:0016020,GO:0016462,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0070566,GO:0071704,GO:0071944,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 2.7.7.53,3.6.1.13,3.6.1.55,3.6.1.67 ko:K01515,ko:K03574,ko:K08310,ko:K19710 ko00230,ko00790,map00230,map00790 M00126 R00126,R01054,R01618,R04638 RC00002,RC02753,RC02795 ko00000,ko00001,ko00002,ko01000,ko03400 Bacteria 27XKW@189775,2G6SB@200795,COG0494@1,COG0494@2,COG0537@1,COG0537@2 NA|NA|NA FGL HIT domain MAG.T1.121_01676 309801.trd_A0816 2.9e-103 382.5 Thermomicrobia Bacteria 27XNK@189775,2G66B@200795,COG1086@1,COG1086@2,COG2148@1,COG2148@2 NA|NA|NA M PFAM sugar transferase MAG.T1.121_01678 485913.Krac_0971 1.4e-53 216.9 Chloroflexi hisI GO:0000105,GO:0003674,GO:0003824,GO:0004635,GO:0004636,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.4.19,3.5.4.25,3.6.1.31,5.3.1.16 ko:K01496,ko:K01497,ko:K01814,ko:K11755 ko00340,ko00740,ko00790,ko01100,ko01110,ko01230,ko02024,map00340,map00740,map00790,map01100,map01110,map01230,map02024 M00026,M00125 R00425,R04035,R04037,R04640 RC00002,RC00293,RC00945,RC01055,RC02504 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1897,iECNA114_1301.ECNA114_0880,iECW_1372.ECW_m2186,iEKO11_1354.EKO11_1768,iHN637.CLJU_RS05760,iSB619.SA_RS14110,iUMN146_1321.UM146_06665,iWFL_1372.ECW_m2186,iYO844.BSU34860 Bacteria 2G6YA@200795,COG0139@1,COG0139@2 NA|NA|NA E belongs to the PRA-CH family MAG.T1.121_01679 1121472.AQWN01000002_gene2276 1e-94 353.2 Peptococcaceae hisF ko:K02500 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 Bacteria 1TP0W@1239,24900@186801,260VM@186807,COG0107@1,COG0107@2 NA|NA|NA E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit MAG.T1.121_01680 720554.Clocl_3924 2.1e-62 245.7 Ruminococcaceae hisA GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_0388 Bacteria 1V1IR@1239,24GBJ@186801,3WH1N@541000,COG0106@1,COG0106@2 NA|NA|NA E 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase MAG.T1.121_01681 1382306.JNIM01000001_gene1884 1.1e-46 193.4 Chloroflexi hisH ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 Bacteria 2G6FD@200795,COG0118@1,COG0118@2 NA|NA|NA E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR MAG.T1.121_01682 1260251.SPISAL_00330 1.9e-48 199.1 Chromatiales hisB GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0004424,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042578,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23,2.6.1.9,3.1.3.15,4.2.1.19 ko:K00013,ko:K00817,ko:K01089,ko:K01693 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R01158,R01163,R03012,R03013,R03243,R03457 RC00006,RC00017,RC00099,RC00242,RC00463,RC00888,RC00932 ko00000,ko00001,ko00002,ko01000,ko01007 iECO111_1330.ECO111_2746,iECS88_1305.ECS88_2121,iJN746.PP_0289,iLJ478.TM1039,iSB619.SA_RS14130,iUMNK88_1353.UMNK88_2570 Bacteria 1MWBS@1224,1RPA9@1236,1WVVY@135613,COG0131@1,COG0131@2 NA|NA|NA E imidazoleglycerol-phosphate dehydratase MAG.T1.121_01683 357808.RoseRS_3872 4.1e-73 282.0 Chloroflexia hisC 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 2G5U4@200795,37543@32061,COG0079@1,COG0079@2 NA|NA|NA E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily MAG.T1.121_01684 525904.Tter_0658 1e-92 346.7 unclassified Bacteria hisG GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 iECSF_1327.ECSF_1909 Bacteria 2NPA9@2323,COG0040@1,COG0040@2 NA|NA|NA F ATP phosphoribosyltransferase MAG.T1.121_01685 234267.Acid_5841 8e-59 234.6 Acidobacteria trmA GO:0000049,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016740,GO:0016741,GO:0019843,GO:0030488,GO:0030696,GO:0030697,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363 2.1.1.190,2.1.1.35 ko:K00557,ko:K03215 ko00000,ko01000,ko03009,ko03016 Bacteria 3Y3SF@57723,COG2265@1,COG2265@2 NA|NA|NA J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family MAG.T1.121_01686 1386089.N865_20490 8.7e-19 100.5 Bacteria smf ko:K04096 ko00000 Bacteria COG0758@1,COG0758@2 NA|NA|NA LU DNA mediated transformation MAG.T1.121_01687 324925.Ppha_1462 3.2e-106 392.9 Bacteria ko:K13527 ko03050,map03050 M00342 ko00000,ko00001,ko00002,ko03051 Bacteria COG0464@1,COG0464@2 NA|NA|NA O ATPase activity MAG.T1.121_01688 479434.Sthe_2726 1.5e-182 646.0 Thermomicrobia comM ko:K06400,ko:K07391 ko00000 Bacteria 27Y2X@189775,2G65P@200795,COG0606@1,COG0606@2 NA|NA|NA O Magnesium chelatase, subunit ChlI MAG.T1.121_01689 1209984.BN978_00703 7e-70 272.3 Mycobacteriaceae 2.7.11.1 ko:K08282 ko00000,ko01000 Bacteria 233DM@1762,2GIZ1@201174,COG2197@1,COG2197@2,COG3903@1,COG3903@2 NA|NA|NA K involved in signal transduction (via phosphorylation) involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites catalytic activity ATP a protein ADP a phosphoprotein MAG.T1.121_01690 610130.Closa_3269 3.6e-21 108.6 Lachnoclostridium fchA Bacteria 1V14R@1239,22054@1506553,24D90@186801,COG3404@1,COG3404@2 NA|NA|NA E COG COG3404 Methenyl tetrahydrofolate cyclohydrolase MAG.T1.121_01691 552811.Dehly_1425 7.1e-156 557.4 Dehalococcoidia purH GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 iHN637.CLJU_RS04230,iJN678.purH Bacteria 2G5JG@200795,34CRG@301297,COG0138@1,COG0138@2 NA|NA|NA F AICARFT/IMPCHase bienzyme MAG.T1.121_01692 1123319.AUBE01000027_gene4770 6.2e-77 295.0 Actinobacteria ko:K01999 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 2IDGM@201174,COG0683@1,COG0683@2 NA|NA|NA E Receptor family ligand binding region MAG.T1.121_01693 1172188.KB911823_gene686 5.9e-16 91.3 Actinobacteria Bacteria 2BF47@1,2IM74@201174,328WE@2 NA|NA|NA MAG.T1.121_01695 479434.Sthe_3070 2e-105 389.4 Bacteria 2.6.1.1 ko:K11358 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 Bacteria COG0436@1,COG0436@2 NA|NA|NA E Aminotransferase MAG.T1.121_01696 1382356.JQMP01000003_gene1431 4.6e-203 714.1 Thermomicrobia guaB GO:0003674,GO:0003824,GO:0003938,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006183,GO:0006195,GO:0006204,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009125,GO:0009126,GO:0009127,GO:0009128,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009154,GO:0009156,GO:0009158,GO:0009161,GO:0009163,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009169,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009261,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046039,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046434,GO:0046483,GO:0046700,GO:0050896,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0072523,GO:0090407,GO:0097292,GO:0097293,GO:1901068,GO:1901070,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 iAPECO1_1312.APECO1_4018,iECABU_c1320.ECABU_c28100,iECP_1309.ECP_2510,iECSF_1327.ECSF_2349,iUTI89_1310.UTI89_C2826,ic_1306.c3027 Bacteria 27XW4@189775,2G5ZX@200795,COG0516@1,COG0516@2,COG0517@1,COG0517@2 NA|NA|NA F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth MAG.T1.121_01697 479434.Sthe_2464 3.5e-83 315.1 Thermomicrobia ko:K03496,ko:K12055 ko00000,ko02044,ko03036,ko04812 3.A.7.11.1 Bacteria 27Y51@189775,2G62U@200795,COG1192@1,COG1192@2 NA|NA|NA D Anion-transporting ATPase MAG.T1.121_01698 309801.trd_1960 8.2e-46 191.4 Thermomicrobia enhA_2 Bacteria 27XVB@189775,2G6ZY@200795,COG1376@1,COG1376@2,COG5479@1,COG5479@2 NA|NA|NA M L,D-transpeptidase catalytic domain MAG.T1.121_01699 479434.Sthe_0653 3.2e-65 255.4 Thermomicrobia pyrF GO:0003674,GO:0003824,GO:0004590,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.10,4.1.1.23 ko:K01591,ko:K13421 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00051 R00965,R01870,R08231 RC00063,RC00409,RC00611 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS17585 Bacteria 27XX0@189775,2G692@200795,COG0284@1,COG0284@2 NA|NA|NA F Belongs to the OMP decarboxylase family. Type 2 subfamily MAG.T1.121_01700 309801.trd_0006 4.5e-98 364.8 Thermomicrobia ilvA_1 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 Bacteria 27XYI@189775,2G5YN@200795,COG1171@1,COG1171@2 NA|NA|NA E Pyridoxal-phosphate dependent enzyme MAG.T1.121_01701 479434.Sthe_0655 1.2e-57 231.5 Thermomicrobia Bacteria 27XW1@189775,2GB7U@200795,COG0457@1,COG0457@2 NA|NA|NA S Tetratricopeptide repeat MAG.T1.121_01702 1382356.JQMP01000003_gene1849 3.6e-22 110.5 Thermomicrobia fdxA Bacteria 27YGX@189775,2G75G@200795,COG1146@1,COG1146@2 NA|NA|NA C PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein MAG.T1.121_01703 479434.Sthe_0656 4.8e-11 76.6 Thermomicrobia Bacteria 27XJ8@189775,2G72P@200795,COG0631@1,COG0631@2 NA|NA|NA T protein serine/threonine phosphatase activity MAG.T1.121_01704 479434.Sthe_1363 7.6e-43 180.6 Thermomicrobia purN 2.1.2.2,6.3.2.6,6.3.4.13 ko:K11175,ko:K13713 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04144,R04325,R04326,R04591 RC00026,RC00064,RC00090,RC00162,RC00166,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS04225 Bacteria 27Y8N@189775,2G6ZJ@200795,COG0299@1,COG0299@2 NA|NA|NA F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate MAG.T1.121_01705 479434.Sthe_1530 1.9e-59 236.5 Chloroflexi luxA Bacteria 2G99A@200795,COG2141@1,COG2141@2 NA|NA|NA C Luciferase-like monooxygenase MAG.T1.121_01706 479434.Sthe_2072 3.6e-32 145.2 Thermomicrobia ctc GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02897 ko03010,map03010 M00178 ko00000,ko00001,ko00002,ko03011 Bacteria 27YEB@189775,2G7A4@200795,COG1825@1,COG1825@2 NA|NA|NA J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance MAG.T1.121_01707 479434.Sthe_1461 1.4e-101 376.3 Thermomicrobia oppB GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 ko:K02033 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 27XQJ@189775,2G5Z7@200795,COG0601@1,COG0601@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component MAG.T1.121_01708 479434.Sthe_1460 2.4e-88 332.4 Thermomicrobia oppC ko:K02034,ko:K15582 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 27XQD@189775,2G63I@200795,COG1173@1,COG1173@2 NA|NA|NA EP N-terminal TM domain of oligopeptide transport permease C MAG.T1.121_01709 525904.Tter_2446 6.5e-31 141.0 unclassified Bacteria Bacteria 2NRIC@2323,COG2197@1,COG2197@2 NA|NA|NA K helix_turn_helix, Lux Regulon MAG.T1.121_01710 1128421.JAGA01000002_gene1677 1.5e-49 203.4 unclassified Bacteria 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 Bacteria 2NR4X@2323,COG0265@1,COG0265@2 NA|NA|NA O Trypsin-like peptidase domain MAG.T1.121_01711 479434.Sthe_3217 1.2e-62 246.9 Thermomicrobia 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 Bacteria 27Z1U@189775,2GBRP@200795,COG0265@1,COG0265@2 NA|NA|NA O Domain present in PSD-95, Dlg, and ZO-1/2. MAG.T1.121_01712 604354.TSIB_0894 8.8e-74 284.3 Archaea Archaea COG0436@1,arCOG04333@2157 NA|NA|NA E aminotransferase class I and II MAG.T1.121_01713 1336243.JAEA01000007_gene674 3e-55 221.5 Methylobacteriaceae coxD Bacteria 1JSBQ@119045,1MV5I@1224,2TREB@28211,COG0714@1,COG0714@2 NA|NA|NA S AAA domain (dynein-related subfamily) MAG.T1.121_01714 479434.Sthe_1402 1.2e-104 387.1 Thermomicrobia coxE ko:K07161 ko00000 Bacteria 27XNE@189775,2G5IW@200795,COG3552@1,COG3552@2 NA|NA|NA S VWA domain containing CoxE-like protein MAG.T1.121_01715 309801.trd_1211 3.2e-31 141.0 Thermomicrobia pucA ko:K07402 ko00000 Bacteria 27YDJ@189775,2G6Z8@200795,COG1975@1,COG1975@2 NA|NA|NA O XdhC and CoxI family MAG.T1.121_01716 1128421.JAGA01000002_gene85 5.3e-59 234.6 unclassified Bacteria pucA ko:K07402 ko00000 Bacteria 2NPTS@2323,COG1975@1,COG1975@2 NA|NA|NA O XdhC and CoxI family MAG.T1.121_01717 269799.Gmet_2140 4e-30 138.3 Desulfuromonadales 2.7.7.76 ko:K07141 ko00790,map00790 R11582 ko00000,ko00001,ko01000 Bacteria 1MW0X@1224,2WPMA@28221,42SCH@68525,43SR2@69541,COG2068@1,COG2068@2 NA|NA|NA S 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase MAG.T1.121_01718 1122138.AQUZ01000025_gene2839 5.9e-27 127.9 Propionibacteriales Bacteria 2IIM0@201174,4DSC8@85009,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family MAG.T1.121_01720 1382356.JQMP01000004_gene673 9.8e-149 533.5 Thermomicrobia 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 27XN6@189775,2G7UK@200795,COG0001@1,COG0001@2 NA|NA|NA H Aminotransferase class-III MAG.T1.121_01721 479434.Sthe_0126 1.4e-86 326.6 Thermomicrobia 4.4.1.15 ko:K05396 ko00270,map00270 R01874 RC00382 ko00000,ko00001,ko01000 Bacteria 27YZ5@189775,2G6PX@200795,COG2515@1,COG2515@2 NA|NA|NA E Pyridoxal-phosphate dependent enzyme MAG.T1.121_01722 479434.Sthe_0303 3.5e-197 695.3 Thermomicrobia priA GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 ko:K04066 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 27XP2@189775,2G60J@200795,COG1198@1,COG1198@2 NA|NA|NA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA MAG.T1.121_01723 1382356.JQMP01000003_gene1306 2.5e-52 211.8 Thermomicrobia def GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008463,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 2.1.2.9,3.5.1.88 ko:K00604,ko:K01462 ko00670,ko00970,map00670,map00970 R03940 RC00026,RC00165 ko00000,ko00001,ko01000 Bacteria 27YB2@189775,2G6VE@200795,COG0242@1,COG0242@2 NA|NA|NA J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions MAG.T1.121_01724 575540.Isop_2355 1.1e-101 376.7 Planctomycetes Bacteria 2IYD5@203682,COG3509@1,COG3509@2 NA|NA|NA Q Carbohydrate family 9 binding domain-like MAG.T1.121_01725 1382356.JQMP01000003_gene1307 3.8e-55 221.5 Thermomicrobia gmk GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 iYO844.BSU15680 Bacteria 27XXM@189775,2G6EW@200795,COG0194@1,COG0194@2 NA|NA|NA F Essential for recycling GMP and indirectly, cGMP MAG.T1.121_01726 479434.Sthe_0380 3.9e-113 415.6 Thermomicrobia FbpA ko:K12341 ko03070,map03070 ko00000,ko00001,ko02044 1.B.40.1.1 Bacteria 27XJZ@189775,2G5TC@200795,COG1293@1,COG1293@2 NA|NA|NA K Fibronectin-binding protein A N-terminus (FbpA) MAG.T1.121_01727 309801.trd_1617 4.7e-58 231.5 Thermomicrobia tatC GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 ko:K03118 ko03060,ko03070,map03060,map03070 M00336 ko00000,ko00001,ko00002,ko02044 2.A.64 Bacteria 27XZG@189775,2G6SP@200795,COG0805@1,COG0805@2 NA|NA|NA U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes MAG.T1.121_01728 696369.KI912183_gene876 5.1e-17 94.0 Peptococcaceae acpP GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 ko:K02078 ko00000,ko00001 Bacteria 1VEE3@1239,24QME@186801,262SV@186807,COG0236@1,COG0236@2 NA|NA|NA IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis MAG.T1.121_01729 1382356.JQMP01000003_gene1311 1.2e-32 146.4 Thermomicrobia nusB ko:K03625 ko00000,ko03009,ko03021 Bacteria 27YFI@189775,2G6XA@200795,COG0781@1,COG0781@2 NA|NA|NA K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons MAG.T1.121_01730 479434.Sthe_0376 6e-170 604.0 Thermomicrobia accC 6.3.4.14,6.4.1.2,6.4.1.3 ko:K01961,ko:K11263 ko00061,ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376,M00741 R00742,R01859,R04385 RC00040,RC00097,RC00253,RC00367,RC00609 ko00000,ko00001,ko00002,ko01000 Bacteria 27XG8@189775,2G5YA@200795,COG0439@1,COG0439@2 NA|NA|NA I Biotin carboxylase C-terminal domain MAG.T1.121_01731 479434.Sthe_0375 1.4e-85 322.8 Thermomicrobia Bacteria 27XUY@189775,2G5KB@200795,COG1028@1,COG1028@2 NA|NA|NA IQ PFAM short-chain dehydrogenase reductase SDR MAG.T1.121_01732 479434.Sthe_0373 2.1e-111 409.1 Thermomicrobia fabH GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 27XWK@189775,2G630@200795,COG0332@1,COG0332@2 NA|NA|NA I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids MAG.T1.121_01733 479434.Sthe_0372 1.3e-17 95.1 Thermomicrobia rpmF GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904 ko:K02911 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011,ko03029 Bacteria 27YMM@189775,2G7EA@200795,COG0333@1,COG0333@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL32 family MAG.T1.121_01734 479434.Sthe_0371 1.8e-34 152.5 Thermomicrobia yceD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 ko:K07040 ko00000 Bacteria 27YCW@189775,2G6Z5@200795,COG1399@1,COG1399@2 NA|NA|NA S Uncharacterized ACR, COG1399 MAG.T1.121_01735 479434.Sthe_1884 1.1e-12 80.1 Thermomicrobia Bacteria 27YI5@189775,2G79J@200795,COG0711@1,COG0711@2 NA|NA|NA C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) MAG.T1.121_01736 1382356.JQMP01000004_gene444 3e-41 174.9 Thermomicrobia coaD GO:0003674,GO:0003824,GO:0004595,GO:0005488,GO:0005515,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0015939,GO:0015940,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046390,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 iPC815.YPO0053,iSDY_1059.SDY_4064 Bacteria 27Y7C@189775,2G6NZ@200795,COG0669@1,COG0669@2 NA|NA|NA F Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate MAG.T1.121_01737 479434.Sthe_1886 1.1e-58 233.0 Thermomicrobia rsmD GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052913,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.171 ko:K08316 R07234 RC00003 ko00000,ko01000,ko03009 Bacteria 27Y9Y@189775,2G6Y8@200795,COG0742@1,COG0742@2 NA|NA|NA L Conserved hypothetical protein 95 MAG.T1.121_01738 1382356.JQMP01000004_gene457 4.1e-171 608.2 Thermomicrobia recG GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 ko:K03655 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 27XT4@189775,2G5YM@200795,COG1200@1,COG1200@2 NA|NA|NA L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) MAG.T1.121_01739 1535287.JP74_17305 8.1e-76 292.0 Bacteria Bacteria COG0383@1,COG0383@2 NA|NA|NA G mannose metabolic process MAG.T1.121_01740 1123321.KB905819_gene5955 2.7e-66 258.8 Actinobacteria ko:K02026,ko:K17317 ko02010,map02010 M00207,M00605 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.24,3.A.1.1.30 Bacteria 2GJNN@201174,COG0395@1,COG0395@2 NA|NA|NA G PFAM binding-protein-dependent transport systems inner membrane component MAG.T1.121_01741 1123322.KB904680_gene3292 1.4e-82 313.2 Actinobacteria ko:K02025,ko:K15771 ko02010,map02010 M00207,M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.2 Bacteria 2GKJI@201174,COG1175@1,COG1175@2 NA|NA|NA G PFAM binding-protein-dependent transport systems inner membrane component MAG.T1.121_01742 391037.Sare_2999 4.2e-80 305.4 Micromonosporales ko:K02027,ko:K10117 ko02010,map02010 M00196,M00207 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.28 Bacteria 2HUDE@201174,4DEGX@85008,COG1653@1,COG1653@2 NA|NA|NA G Bacterial extracellular solute-binding protein MAG.T1.121_01743 469383.Cwoe_4787 2.2e-43 182.6 Actinobacteria ko:K05799 ko00000,ko03000 Bacteria 2IB40@201174,COG2186@1,COG2186@2 NA|NA|NA K FCD MAG.T1.121_01744 561175.KB894094_gene1907 7.1e-216 757.7 Streptosporangiales Bacteria 2GM02@201174,4EI38@85012,COG0383@1,COG0383@2 NA|NA|NA G Alpha mannosidase, middle domain MAG.T1.121_01745 1120972.AUMH01000008_gene2008 9.6e-188 662.9 Bacilli gudD 4.2.1.40 ko:K01706 ko00053,ko01100,map00053,map01100 R02752,R08056 RC00543 ko00000,ko00001,ko01000 Bacteria 1TUWS@1239,4HCCY@91061,COG4948@1,COG4948@2 NA|NA|NA M Belongs to the mandelate racemase muconate lactonizing enzyme family MAG.T1.121_01746 479434.Sthe_1099 6.9e-148 530.4 Thermomicrobia 1.5.3.1 ko:K00303 ko00260,ko01100,map00260,map01100 R00610 RC00060,RC00557 ko00000,ko00001,ko01000 Bacteria 27YWR@189775,2G6HT@200795,COG0665@1,COG0665@2 NA|NA|NA E NAD(P)-binding Rossmann-like domain MAG.T1.121_01747 314230.DSM3645_05585 2.1e-134 486.1 Planctomycetes lplT GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0019637,GO:0031224,GO:0031226,GO:0044237,GO:0044238,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0046486,GO:0071704,GO:0071944 2.3.1.40,6.2.1.20 ko:K05939,ko:K08227 ko00071,ko00564,map00071,map00564 R01406,R04864 RC00014,RC00039,RC00041 ko00000,ko00001,ko01000,ko02000 2.A.1.42 iEC042_1314.EC042_3033,iECIAI39_1322.ECIAI39_3255,iEcSMS35_1347.EcSMS35_2983 Bacteria 2IXNF@203682,COG0204@1,COG0204@2,COG0318@1,COG0318@2,COG0477@1,COG0477@2 NA|NA|NA I AMP-dependent synthetase and ligase MAG.T1.121_01748 309801.trd_0463 6.3e-128 464.5 Thermomicrobia MA20_01895 Bacteria 27Y46@189775,2G5SE@200795,COG1233@1,COG1233@2 NA|NA|NA Q Flavin containing amine oxidoreductase MAG.T1.121_01749 1120950.KB892757_gene6519 6.2e-11 74.3 Propionibacteriales ko:K03695,ko:K03696 ko01100,ko04213,map01100,map04213 ko00000,ko00001,ko03110 Bacteria 2GKKF@201174,4DRWE@85009,COG0542@1,COG0542@2 NA|NA|NA O Clp amino terminal domain, pathogenicity island component MAG.T1.121_01750 215803.DB30_5213 2e-38 166.8 Myxococcales ppe2 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.1.3.9,3.2.1.4 ko:K01179,ko:K04618,ko:K22390 ko00052,ko00500,ko01100,map00052,map00500,map01100 R01098,R06200,R11307,R11308 RC00194 ko00000,ko00001,ko01000 GH5,GH9 Bacteria 1N85S@1224,2XA07@28221,2YZHM@29,42WZ6@68525,COG1409@1,COG1409@2,COG3291@1,COG3291@2 NA|NA|NA S PKD domain MAG.T1.121_01751 316274.Haur_4969 3.5e-152 545.8 Chloroflexia deaD GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003724,GO:0003725,GO:0003727,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006417,GO:0006725,GO:0006807,GO:0006950,GO:0006996,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009987,GO:0010468,GO:0010501,GO:0010556,GO:0010557,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019439,GO:0022607,GO:0022613,GO:0022618,GO:0030312,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031330,GO:0032268,GO:0032270,GO:0032574,GO:0032575,GO:0033554,GO:0033592,GO:0034057,GO:0034248,GO:0034250,GO:0034458,GO:0034459,GO:0034622,GO:0034641,GO:0034655,GO:0042254,GO:0042255,GO:0042273,GO:0042623,GO:0043170,GO:0043487,GO:0043488,GO:0043489,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045934,GO:0046483,GO:0046700,GO:0048255,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051247,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0061013,GO:0065003,GO:0065007,GO:0065008,GO:0070035,GO:0070417,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097617,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902369,GO:1902373,GO:1903311,GO:1903312,GO:2000112 3.6.4.13 ko:K05592 ko03018,map03018 ko00000,ko00001,ko01000,ko03009,ko03019 Bacteria 2G5VR@200795,376J4@32061,COG0513@1,COG0513@2 NA|NA|NA L Belongs to the DEAD box helicase family MAG.T1.121_01753 1382356.JQMP01000003_gene1907 9.7e-82 310.8 Thermomicrobia 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 Bacteria 27XMU@189775,2G64M@200795,COG0285@1,COG0285@2 NA|NA|NA H Mur ligase family, glutamate ligase domain MAG.T1.121_01755 344747.PM8797T_06872 3.9e-79 301.6 Planctomycetes ndh 1.6.99.3 ko:K03885 ko00190,map00190 ko00000,ko00001,ko01000 Bacteria 2IXBA@203682,COG1252@1,COG1252@2 NA|NA|NA C NADH dehydrogenase, FAD-containing subunit MAG.T1.121_01756 926560.KE387027_gene611 3.9e-94 351.7 Deinococcus-Thermus ko:K02031,ko:K02032 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 1WNDB@1297,COG1123@1,COG4172@2 NA|NA|NA P Oligopeptide/dipeptide transporter, C-terminal region MAG.T1.121_01757 357808.RoseRS_4542 1.6e-246 859.0 Chloroflexia yoaE Bacteria 2G5X7@200795,3752D@32061,COG0243@1,COG0243@2 NA|NA|NA C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family MAG.T1.121_01758 266117.Rxyl_0142 1.1e-29 136.3 Rubrobacteria osmC ko:K04063 ko00000 Bacteria 2IFFB@201174,4CQIW@84995,COG1764@1,COG1764@2 NA|NA|NA O OsmC-like protein MAG.T1.121_01759 479434.Sthe_2909 4.5e-152 544.7 Thermomicrobia ycbD ko:K22187 ko00040,map00040 R11768 RC00080 ko00000,ko00001,ko01000 Bacteria 27Y0H@189775,2G7YU@200795,COG1012@1,COG1012@2 NA|NA|NA C Belongs to the aldehyde dehydrogenase family MAG.T1.121_01762 926560.KE387027_gene615 4.6e-169 601.7 Deinococcus-Thermus Bacteria 1WN1X@1297,COG4409@1,COG4409@2 NA|NA|NA G exo-alpha-(2->6)-sialidase activity MAG.T1.121_01763 1122223.KB890697_gene1149 1.1e-248 866.3 Bacteria ko:K02035 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria COG0747@1,COG0747@2,COG3889@1,COG3889@2 NA|NA|NA E dipeptide transport MAG.T1.121_01764 1122223.KB890697_gene1150 1.3e-124 453.0 Deinococcus-Thermus appB ko:K02033 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 1WIUD@1297,COG0601@1,COG0601@2 NA|NA|NA EP ABC-type dipeptide oligopeptide nickel transport systems, permease components MAG.T1.121_01765 1122223.KB890697_gene1151 1.1e-113 417.2 Bacteria oppC ko:K02034,ko:K15582 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria COG1173@1,COG1173@2 NA|NA|NA P ABC-type dipeptide oligopeptide nickel transport systems, permease components MAG.T1.121_01766 357808.RoseRS_1377 1.1e-111 410.2 Chloroflexia cefD 5.1.1.17 ko:K04127,ko:K11325,ko:K21174 ko00311,ko01059,ko01100,ko01130,map00311,map01059,map01100,map01130 M00673,M00825 R04147 RC00302 ko00000,ko00001,ko00002,ko01000 Bacteria 2G62I@200795,3770T@32061,COG0520@1,COG0520@2 NA|NA|NA E PFAM aminotransferase class V MAG.T1.121_01767 1382304.JNIL01000001_gene1452 1.4e-67 263.1 Alicyclobacillaceae Bacteria 1TQ80@1239,279KB@186823,4HASE@91061,COG1028@1,COG1028@2 NA|NA|NA IQ KR domain MAG.T1.121_01768 243233.MCA2487 6.1e-159 567.4 Methylococcales ugd 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 Bacteria 1MW5U@1224,1RMVW@1236,1XE5W@135618,COG1004@1,COG1004@2 NA|NA|NA C Belongs to the UDP-glucose GDP-mannose dehydrogenase family MAG.T1.121_01769 479434.Sthe_0318 4.3e-168 598.2 Thermomicrobia rnj GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004527,GO:0004532,GO:0004534,GO:0004540,GO:0005488,GO:0005515,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008409,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042802,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0090503,GO:0140098,GO:1901360 ko:K12574 ko03018,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 27XK2@189775,2G611@200795,COG0595@1,COG0595@2 NA|NA|NA S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay MAG.T1.121_01770 525904.Tter_1282 5.4e-33 147.1 unclassified Bacteria Bacteria 2NRCK@2323,COG1733@1,COG1733@2 NA|NA|NA K HxlR-like helix-turn-helix MAG.T1.121_01771 326427.Cagg_1565 6.6e-48 197.2 Chloroflexia Bacteria 2G6G9@200795,376J9@32061,COG2353@1,COG2353@2 NA|NA|NA S Belongs to the UPF0312 family MAG.T1.121_01772 1382306.JNIM01000001_gene284 9.1e-33 147.5 Chloroflexi 3.5.1.115 ko:K18455 ko00000,ko01000 Bacteria 2G6W3@200795,COG2120@1,COG2120@2 NA|NA|NA S PFAM LmbE family protein MAG.T1.121_01773 485913.Krac_0145 7.3e-28 131.0 Chloroflexi 2.7.1.12 ko:K00851 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 R01737 RC00002,RC00017 ko00000,ko00001,ko01000 Bacteria 2G5KJ@200795,COG1070@1,COG1070@2 NA|NA|NA G carbohydrate kinase FGGY MAG.T1.121_01775 1487953.JMKF01000065_gene4642 4.3e-116 425.2 Oscillatoriales GO:0001503,GO:0001505,GO:0001507,GO:0001540,GO:0001649,GO:0002076,GO:0002791,GO:0002793,GO:0003674,GO:0003824,GO:0003990,GO:0004104,GO:0005488,GO:0005515,GO:0005518,GO:0005575,GO:0005576,GO:0005604,GO:0005605,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005794,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006581,GO:0006629,GO:0006644,GO:0006650,GO:0006656,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0007155,GO:0007267,GO:0007268,GO:0007271,GO:0007275,GO:0007399,GO:0007416,GO:0007517,GO:0008144,GO:0008150,GO:0008152,GO:0008283,GO:0008291,GO:0008610,GO:0008654,GO:0009056,GO:0009058,GO:0009059,GO:0009611,GO:0009987,GO:0010646,GO:0010648,GO:0010817,GO:0012505,GO:0016020,GO:0016043,GO:0016787,GO:0016788,GO:0017144,GO:0017171,GO:0019538,GO:0019637,GO:0022607,GO:0022610,GO:0023051,GO:0023052,GO:0023057,GO:0030154,GO:0031012,GO:0032222,GO:0032223,GO:0032501,GO:0032502,GO:0032879,GO:0032880,GO:0033218,GO:0034641,GO:0034645,GO:0042133,GO:0042135,GO:0042136,GO:0042165,GO:0042166,GO:0042277,GO:0042445,GO:0042447,GO:0042562,GO:0042737,GO:0042802,GO:0042803,GO:0042982,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043236,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044420,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045017,GO:0045202,GO:0046470,GO:0046474,GO:0046483,GO:0046486,GO:0046983,GO:0048468,GO:0048471,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048731,GO:0048856,GO:0048869,GO:0050708,GO:0050714,GO:0050789,GO:0050794,GO:0050804,GO:0050805,GO:0050808,GO:0050840,GO:0050896,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051222,GO:0051223,GO:0052689,GO:0061061,GO:0062023,GO:0065007,GO:0065008,GO:0070201,GO:0070405,GO:0071704,GO:0071840,GO:0071944,GO:0090087,GO:0090304,GO:0090407,GO:0097164,GO:0098916,GO:0099177,GO:0099536,GO:0099537,GO:1900619,GO:1901360,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903530,GO:1903532,GO:1904951 ko:K03668,ko:K03929 ko00000,ko01000 CE10 Bacteria 1GK00@1117,1HGX8@1150,COG2272@1,COG2272@2,COG3187@1,COG3187@2 NA|NA|NA I Carboxylesterase family MAG.T1.121_01776 383372.Rcas_3853 1.1e-112 413.7 Chloroflexi Bacteria 2G90Z@200795,COG2133@1,COG2133@2 NA|NA|NA G pyrroloquinoline quinone binding MAG.T1.121_01777 1379698.RBG1_1C00001G0743 7.3e-22 110.5 unclassified Bacteria dinB ko:K07552 ko00000,ko02000 2.A.1.2 Bacteria 2NRHG@2323,COG2318@1,COG2318@2 NA|NA|NA S DinB superfamily MAG.T1.121_01778 1121085.AUCI01000011_gene1758 3.1e-63 248.8 Bacillus 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 Bacteria 1TWPP@1239,1ZD09@1386,4HCTV@91061,COG0451@1,COG0451@2 NA|NA|NA GM GDP-mannose 4,6 dehydratase MAG.T1.121_01780 926560.KE387023_gene1442 5.9e-83 315.5 Deinococcus-Thermus cphA 6.3.2.13,6.3.2.29,6.3.2.30 ko:K01928,ko:K03802 ko00300,ko00550,map00300,map00550 R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 Bacteria 1WM7H@1297,COG0189@1,COG0189@2,COG0769@1,COG0769@2 NA|NA|NA HJM RimK-like ATP-grasp domain MAG.T1.121_01784 479434.Sthe_0022 3.3e-122 445.3 Thermomicrobia Bacteria 27XNZ@189775,2G7F0@200795,COG3567@1,COG3567@2 NA|NA|NA S Phage portal protein, SPP1 Gp6-like MAG.T1.121_01785 479434.Sthe_1268 7.1e-15 88.2 Thermomicrobia Bacteria 27Z6N@189775,2GBEQ@200795,COG4454@1,COG4454@2 NA|NA|NA MAG.T1.121_01786 1382356.JQMP01000003_gene1405 4.9e-12 78.2 Thermomicrobia Bacteria 27YQ4@189775,2BQM4@1,2GA1W@200795,32JH6@2 NA|NA|NA MAG.T1.121_01789 479434.Sthe_0018 2e-80 307.0 Thermomicrobia Bacteria 27YBE@189775,2AS16@1,2GA0F@200795,31HDI@2 NA|NA|NA MAG.T1.121_01791 452863.Achl_3735 2e-69 269.6 Micrococcaceae ko:K02016 ko02010,map02010 M00240 ko00000,ko00001,ko00002,ko02000 3.A.1.14 Bacteria 1W7K2@1268,2IA3G@201174,COG0614@1,COG0614@2 NA|NA|NA P Periplasmic binding protein MAG.T1.121_01793 1235792.C808_01392 6.8e-65 255.0 Firmicutes ko:K14358 ko00000,ko01002 Bacteria 1V44V@1239,COG4690@1,COG4690@2 NA|NA|NA E Peptidase family C69 MAG.T1.121_01794 1040989.AWZU01000005_gene159 4.9e-27 127.5 Bradyrhizobiaceae Bacteria 1RCZT@1224,2U735@28211,3JY2H@41294,COG3795@1,COG3795@2 NA|NA|NA S YCII-related domain MAG.T1.121_01795 326427.Cagg_3437 2.4e-63 248.4 Chloroflexia 1.8.5.4 ko:K17218 ko00920,map00920 R10152 RC03155 ko00000,ko00001,ko01000 Bacteria 2G6GM@200795,376R0@32061,COG0446@1,COG0446@2 NA|NA|NA S PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase MAG.T1.121_01796 1370121.AUWS01000062_gene3875 7.7e-87 328.9 Mycobacteriaceae Bacteria 233DM@1762,2GIZ1@201174,COG2114@1,COG2114@2,COG3903@1,COG3903@2 NA|NA|NA K involved in signal transduction (via phosphorylation) involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites catalytic activity ATP a protein ADP a phosphoprotein MAG.T1.121_01798 1382356.JQMP01000003_gene1842 5e-27 127.1 Thermomicrobia csoR ko:K21600 ko00000,ko03000 Bacteria 27YK9@189775,2G7H9@200795,COG1937@1,COG1937@2 NA|NA|NA S Metal-sensitive transcriptional repressor MAG.T1.121_01799 35754.JNYJ01000022_gene8124 3.1e-54 219.2 Micromonosporales Bacteria 2GMW5@201174,4D8H8@85008,COG4124@1,COG4124@2 NA|NA|NA G Belongs to the glycosyl hydrolase 26 family MAG.T1.121_01800 479434.Sthe_2271 1.1e-23 118.6 Chloroflexi Bacteria 2G7AA@200795,COG5305@1,COG5305@2 NA|NA|NA S Dolichyl-phosphate-mannose-protein mannosyltransferase MAG.T1.121_01801 485913.Krac_9368 2e-121 443.0 Bacteria 2.4.1.12 ko:K00694 ko00500,ko01100,ko02026,map00500,map01100,map02026 R02889 RC00005 ko00000,ko00001,ko01000,ko01003,ko02000 4.D.3.1.2,4.D.3.1.5,4.D.3.1.6 GT2 Bacteria COG1215@1,COG1215@2 NA|NA|NA M transferase activity, transferring glycosyl groups MAG.T1.121_01802 485913.Krac_9367 1.9e-44 187.2 Bacteria Bacteria 291U1@1,2ZPDU@2 NA|NA|NA M Dolichyl-phosphate-mannose-protein mannosyltransferase MAG.T1.121_01803 240016.ABIZ01000001_gene4355 3.4e-88 332.4 Bacteria Bacteria COG2133@1,COG2133@2 NA|NA|NA G pyrroloquinoline quinone binding MAG.T1.121_01804 266117.Rxyl_3148 8.4e-193 680.6 Rubrobacteria ko:K05559,ko:K05565,ko:K05566 ko00000,ko02000 2.A.63.1,2.A.63.2 Bacteria 2GIT4@201174,4CPXB@84995,COG1009@1,COG1009@2,COG2111@1,COG2111@2 NA|NA|NA CP PFAM NADH Ubiquinone plastoquinone (complex I) MAG.T1.121_01805 266117.Rxyl_1800 8.5e-30 136.7 Rubrobacteria ko:K05559,ko:K05565,ko:K05566 ko00000,ko02000 2.A.63.1,2.A.63.2 Bacteria 2GIT4@201174,4CPXB@84995,COG1009@1,COG1009@2,COG2111@1,COG2111@2 NA|NA|NA CP PFAM NADH Ubiquinone plastoquinone (complex I) MAG.T1.121_01806 266117.Rxyl_3146 6.1e-26 124.0 Rubrobacteria ko:K05567 ko00000,ko02000 2.A.63.1,2.A.63.2 Bacteria 2ISBC@201174,4CQW3@84995,COG1006@1,COG1006@2 NA|NA|NA P PFAM NADH-ubiquinone oxidoreductase chain 4L MAG.T1.121_01807 42256.RradSPS_0975 7.6e-133 480.7 Rubrobacteria ko:K05568 ko00000,ko02000 2.A.63.1,2.A.63.2 Bacteria 2HAC7@201174,4CQ74@84995,COG0651@1,COG0651@2 NA|NA|NA CP NADH ubiquinone plastoquinone MAG.T1.121_01808 42256.RradSPS_0976 1.8e-31 142.5 Rubrobacteria mrpE ko:K05562,ko:K05569 ko00000,ko02000 2.A.63.1,2.A.63.2 Bacteria 2IT9T@201174,4CTPK@84995,COG1863@1,COG1863@2 NA|NA|NA P Cation antiporter MAG.T1.121_01809 266117.Rxyl_1796 1.5e-18 98.6 Rubrobacteria mrpF ko:K05563,ko:K05570 ko00000,ko02000 2.A.63.1,2.A.63.2 iSB619.SA_RS03360,iYO844.BSU31650 Bacteria 2GTPK@201174,4CTVY@84995,COG2212@1,COG2212@2 NA|NA|NA P Multiple resistance and pH regulation protein F MAG.T1.121_01810 266117.Rxyl_1795 2.1e-24 119.0 Rubrobacteria mrpG ko:K05571 ko00000,ko02000 2.A.63.1,2.A.63.2 Bacteria 2HRRR@201174,4CTUG@84995,COG1320@1,COG1320@2 NA|NA|NA P Na H antiporter subunit MAG.T1.121_01812 439292.Bsel_0482 4.1e-19 102.8 Bacilli ko:K20276 ko02024,map02024 ko00000,ko00001 Bacteria 1V3SC@1239,4HFE4@91061,COG1404@1,COG1404@2 NA|NA|NA O Domain of unknown function (DUF4397) MAG.T1.121_01813 292459.STH1938 7.6e-13 80.1 Clostridia Bacteria 1V8FN@1239,25EZV@186801,COG3356@1,COG3356@2 NA|NA|NA S PFAM Neutral alkaline nonlysosomal ceramidase MAG.T1.121_01819 479434.Sthe_3265 1.4e-73 283.5 Thermomicrobia mltG ko:K07082 ko00000 Bacteria 27XHU@189775,2G6G8@200795,COG1559@1,COG1559@2 NA|NA|NA S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation MAG.T1.121_01820 479434.Sthe_3264 1.7e-86 326.2 Thermomicrobia miaA GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 Bacteria 27XIQ@189775,2G5S7@200795,COG0324@1,COG0324@2 NA|NA|NA J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) MAG.T1.121_01821 479434.Sthe_3283 1.5e-80 307.0 Thermomicrobia Bacteria 27XYJ@189775,28HQ3@1,2G9Q4@200795,2Z7XW@2 NA|NA|NA S Protein of unknown function (DUF2851) MAG.T1.121_01822 383372.Rcas_1499 6.2e-93 347.4 Chloroflexi ko:K07046 ko00051,ko01120,map00051,map01120 R10689 RC00537 ko00000,ko00001,ko01000 Bacteria 2G7J1@200795,COG3618@1,COG3618@2 NA|NA|NA S Amidohydrolase MAG.T1.121_01823 309801.trd_A0430 2.2e-153 548.9 Thermomicrobia glnA2 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 Bacteria 27XSZ@189775,2G5U2@200795,COG0174@1,COG0174@2 NA|NA|NA E glutamine synthetase MAG.T1.121_01824 1382356.JQMP01000003_gene1565 1.3e-120 440.3 Thermomicrobia cad 4.1.1.18,4.1.1.19 ko:K01582,ko:K01583,ko:K01585 ko00310,ko00330,ko00960,ko01100,ko01110,map00310,map00330,map00960,map01100,map01110 M00133 R00462,R00566 RC00299 ko00000,ko00001,ko00002,ko01000 iJN678.cad Bacteria 27YUZ@189775,2GA2R@200795,COG1982@1,COG1982@2 NA|NA|NA E Orn/Lys/Arg decarboxylase, C-terminal domain MAG.T1.121_01825 1385935.N836_05535 9.7e-20 104.4 Oscillatoriales 2.3.1.4 ko:K00621 ko00520,map00520 R02058 RC00004,RC00166 ko00000,ko00001,ko01000 Bacteria 1G407@1117,1H9GX@1150,COG0454@1,COG0456@2 NA|NA|NA K PFAM Acetyltransferase (GNAT) family MAG.T1.121_01826 479434.Sthe_2131 4.7e-128 464.5 Thermomicrobia ybdL GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0008144,GO:0008483,GO:0010326,GO:0016740,GO:0016769,GO:0019842,GO:0030170,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0071944,GO:0097159,GO:1901363 2.6.1.17,2.6.1.88 ko:K14267,ko:K14287 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04475,R08618 RC00006,RC00025 ko00000,ko00001,ko00002,ko01000,ko01007 iNJ661.Rv0858c Bacteria 27XZ4@189775,2G5MC@200795,COG0436@1,COG0436@2 NA|NA|NA E Cys/Met metabolism PLP-dependent enzyme MAG.T1.121_01827 1497679.EP56_17645 2.8e-143 515.8 Listeriaceae pepF GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006465,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0051604,GO:0070011,GO:0071704,GO:0140096,GO:1901564 ko:K08602 ko00000,ko01000,ko01002 Bacteria 1TP4P@1239,26JZR@186820,4HA7X@91061,COG1164@1,COG1164@2 NA|NA|NA E Oligopeptidase F MAG.T1.121_01828 485913.Krac_10815 3.1e-128 465.3 Chloroflexi nadA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 Bacteria 2G64Y@200795,COG0379@1,COG0379@2 NA|NA|NA H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate MAG.T1.121_01830 1304880.JAGB01000002_gene1618 2.7e-117 429.1 Clostridia pgi GO:0003674,GO:0003824,GO:0004347,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 iLJ478.TM1385 Bacteria 1TP29@1239,2487A@186801,COG0166@1,COG0166@2 NA|NA|NA G Belongs to the GPI family MAG.T1.121_01831 479434.Sthe_3464 1.5e-13 82.0 Thermomicrobia 1.12.5.1,1.14.14.47,1.5.3.1,1.7.1.15,1.7.7.1,2.1.1.272 ko:K00302,ko:K00362,ko:K00366,ko:K00372,ko:K00491,ko:K05927,ko:K21479 ko00220,ko00260,ko00330,ko00860,ko00910,ko01100,ko01110,ko01120,map00220,map00260,map00330,map00860,map00910,map01100,map01110,map01120 M00530,M00531 R00610,R00787,R00790,R00798,R01106,R11580,R11711,R11712,R11713 RC00060,RC00176,RC00177,RC00330,RC00557,RC01044,RC02812,RC03479 ko00000,ko00001,ko00002,ko01000 Bacteria 27YS3@189775,2G6SN@200795,COG0446@1,COG0446@2,COG1251@1,COG1251@2 NA|NA|NA C BFD-like [2Fe-2S] binding domain MAG.T1.121_01832 479434.Sthe_3464 6.9e-10 70.9 Thermomicrobia 1.12.5.1,1.14.14.47,1.5.3.1,1.7.1.15,1.7.7.1,2.1.1.272 ko:K00302,ko:K00362,ko:K00366,ko:K00372,ko:K00491,ko:K05927,ko:K21479 ko00220,ko00260,ko00330,ko00860,ko00910,ko01100,ko01110,ko01120,map00220,map00260,map00330,map00860,map00910,map01100,map01110,map01120 M00530,M00531 R00610,R00787,R00790,R00798,R01106,R11580,R11711,R11712,R11713 RC00060,RC00176,RC00177,RC00330,RC00557,RC01044,RC02812,RC03479 ko00000,ko00001,ko00002,ko01000 Bacteria 27YS3@189775,2G6SN@200795,COG0446@1,COG0446@2,COG1251@1,COG1251@2 NA|NA|NA C BFD-like [2Fe-2S] binding domain MAG.T1.121_01833 479434.Sthe_2046 2.9e-15 87.8 Chloroflexi Bacteria 29U2R@1,2G9M3@200795,30FC1@2 NA|NA|NA MAG.T1.121_01834 479434.Sthe_2045 9.4e-124 450.3 Bacteria imuB 2.7.7.7 ko:K02346,ko:K14161 ko00000,ko01000,ko03400 Bacteria COG0389@1,COG0389@2 NA|NA|NA L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII MAG.T1.121_01836 479434.Sthe_0944 3.2e-189 668.7 Thermomicrobia ftsK GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 ko:K03466 ko00000,ko03036 3.A.12 Bacteria 27XSG@189775,2G5XC@200795,COG1674@1,COG1674@2 NA|NA|NA D Ftsk_gamma MAG.T1.121_01837 1382356.JQMP01000003_gene2082 5.3e-66 257.3 Thermomicrobia recR GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 ko:K06187 ko03440,map03440 ko00000,ko00001,ko03400 Bacteria 27XUN@189775,2G6CT@200795,COG0353@1,COG0353@2 NA|NA|NA L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO MAG.T1.121_01838 479434.Sthe_0946 3.2e-28 132.9 Thermomicrobia Bacteria 27YNA@189775,2A40S@1,2GADS@200795,30SJA@2 NA|NA|NA MAG.T1.121_01839 309801.trd_0202 1.3e-185 656.4 Thermomicrobia ycf45 Bacteria 27Y49@189775,2G5P5@200795,COG3854@1,COG3854@2 NA|NA|NA S R3H domain MAG.T1.121_01840 1312959.KI914660_gene3795 5.9e-48 197.6 Micrococcaceae tmk GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 1W963@1268,2GNTI@201174,COG0125@1,COG0125@2 NA|NA|NA F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis MAG.T1.121_01841 479434.Sthe_0949 1e-11 76.3 Thermomicrobia Bacteria 27YHY@189775,2G736@200795,COG3870@1,COG3870@2 NA|NA|NA S Cyclic-di-AMP receptor MAG.T1.121_01842 479434.Sthe_0950 4.3e-39 168.7 Thermomicrobia Bacteria 27Y98@189775,2G6VG@200795,COG0143@1,COG0143@2 NA|NA|NA J Double zinc ribbon MAG.T1.121_01843 1382356.JQMP01000003_gene2090 7.9e-75 287.3 Thermomicrobia nadK 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 R00104 RC00002,RC00078 ko00000,ko00001,ko01000 Bacteria 27XIP@189775,2G6NK@200795,COG0061@1,COG0061@2 NA|NA|NA F Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP MAG.T1.121_01844 926569.ANT_03410 9.6e-29 134.0 Chloroflexi 3.6.1.55 ko:K03574 ko00000,ko01000,ko03400 Bacteria 2G6QH@200795,COG1051@1,COG1051@2,COG4111@1,COG4111@2 NA|NA|NA F Belongs to the Nudix hydrolase family MAG.T1.121_01845 1382356.JQMP01000003_gene2091 4.5e-64 251.1 Thermomicrobia 4.1.2.14,4.1.3.42 ko:K01625 ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200 M00008,M00061,M00308,M00631 R00470,R05605 RC00307,RC00308,RC00435 ko00000,ko00001,ko00002,ko01000 Bacteria 27XF9@189775,2G8N9@200795,COG0800@1,COG0800@2 NA|NA|NA G KDPG and KHG aldolase MAG.T1.121_01847 1382305.AZUC01000047_gene861 5.6e-25 121.3 Planococcaceae resA GO:0008150,GO:0009987,GO:0016043,GO:0017004,GO:0022607,GO:0034622,GO:0043933,GO:0044085,GO:0065003,GO:0071840 Bacteria 1VAPY@1239,26ERH@186818,4HIQ3@91061,COG0526@1,COG0526@2 NA|NA|NA CO Catalyzes the reduction of the disulfide bonds in the heme binding site of apocytochrome c MAG.T1.121_01848 1184609.KILIM_004_00120 7.5e-57 227.6 Dermatophilaceae ccsA GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008152,GO:0015886,GO:0016020,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0055114,GO:0071702,GO:0071705,GO:0071944,GO:1901678 Bacteria 2GJR1@201174,4F6E4@85018,COG0755@1,COG0755@2 NA|NA|NA O Cytochrome C assembly protein MAG.T1.121_01849 1121017.AUFG01000010_gene1637 9.5e-57 228.0 Intrasporangiaceae ccs1 ko:K07399 ko00000 Bacteria 2GMGH@201174,4FIKI@85021,COG1333@1,COG1333@2 NA|NA|NA O ResB-like family MAG.T1.121_01850 861299.J421_2831 1.3e-35 156.8 Gemmatimonadetes ccdA ko:K06196 ko00000,ko02000 5.A.1.2 Bacteria 1ZTJC@142182,COG0785@1,COG0785@2 NA|NA|NA O Cytochrome C biogenesis protein transmembrane region MAG.T1.121_01851 479434.Sthe_0953 5.4e-46 191.4 Thermomicrobia recO GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 ko:K03584 ko03440,map03440 ko00000,ko00001,ko03400 Bacteria 27YAT@189775,2G6N7@200795,COG1381@1,COG1381@2 NA|NA|NA L Involved in DNA repair and RecF pathway recombination MAG.T1.121_01852 867845.KI911784_gene2684 4.3e-65 254.6 Chloroflexia trmD GO:0000287,GO:0001510,GO:0002939,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050518,GO:0052906,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228,4.6.1.12 ko:K00554,ko:K01770 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R00597,R05637 RC00002,RC00003,RC00334,RC01440 ko00000,ko00001,ko00002,ko01000,ko03016 Bacteria 2G5MY@200795,375BY@32061,COG0336@1,COG0336@2 NA|NA|NA J Belongs to the RNA methyltransferase TrmD family MAG.T1.121_01853 519989.ECTPHS_03607 5.1e-11 75.1 Chromatiales 3.1.3.102,3.1.3.104 ko:K07025,ko:K20862 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00548,R07280 RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 1N0I6@1224,1RQ41@1236,1WXEC@135613,COG1011@1,COG1011@2 NA|NA|NA S subfamily IA, variant 1 MAG.T1.121_01855 479434.Sthe_0976 3.6e-113 415.6 Thermomicrobia ko:K02035,ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 27XQ9@189775,2G5TA@200795,COG4166@1,COG4166@2 NA|NA|NA E Bacterial extracellular solute-binding proteins, family 5 Middle MAG.T1.121_01857 479434.Sthe_2722 3.5e-46 191.4 Bacteria Bacteria COG0778@1,COG0778@2 NA|NA|NA C coenzyme F420-1:gamma-L-glutamate ligase activity MAG.T1.121_01858 479434.Sthe_2722 1.5e-46 192.6 Bacteria Bacteria COG0778@1,COG0778@2 NA|NA|NA C coenzyme F420-1:gamma-L-glutamate ligase activity MAG.T1.121_01859 1120972.AUMH01000028_gene676 2.2e-12 79.0 Bacilli 1.16.3.3,1.7.2.1 ko:K00368,ko:K02638,ko:K22348 ko00195,ko00910,ko01120,map00195,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko00194,ko01000 Bacteria 1TQJK@1239,4IRUW@91061,COG2132@1,COG2132@2,COG3794@1,COG3794@2 NA|NA|NA Q Multicopper oxidase MAG.T1.121_01860 1205680.CAKO01000030_gene4930 5e-21 107.8 Rhodospirillales ko:K06925 ko00000,ko03016 Bacteria 1N1SU@1224,2JZ5F@204441,2UA9R@28211,COG0454@1,COG0456@2 NA|NA|NA K Acetyltransferase (GNAT) domain MAG.T1.121_01861 483219.LILAB_29540 4.9e-27 129.0 Proteobacteria Bacteria 1NXC3@1224,28M9U@1,2ZANN@2 NA|NA|NA MAG.T1.121_01862 479434.Sthe_0612 6.4e-76 291.2 Thermomicrobia 1.3.1.74 ko:K08070 ko00000,ko01000 Bacteria 27Y6G@189775,2G8RK@200795,COG0265@1,COG0265@2 NA|NA|NA M Domain present in PSD-95, Dlg, and ZO-1/2. MAG.T1.121_01864 1521187.JPIM01000043_gene1923 4.1e-49 201.1 Chloroflexia dps GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0006950,GO:0008150,GO:0008199,GO:0009295,GO:0009605,GO:0009991,GO:0031667,GO:0042594,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0050896,GO:0097159,GO:1901363 ko:K04047 ko00000,ko03036 Bacteria 2G9YH@200795,3779J@32061,COG0783@1,COG0783@2 NA|NA|NA L Belongs to the Dps family MAG.T1.121_01865 1293047.CBMA010000008_gene304 4.9e-08 67.0 Halobacteria Archaea 240TC@183963,2XUI1@28890,COG1520@1,arCOG02482@2157 NA|NA|NA C COG1520 FOG WD40-like repeat MAG.T1.121_01867 1122132.AQYH01000007_gene1927 1.5e-81 309.7 Alphaproteobacteria ko:K07045 ko00000 Bacteria 1MUUR@1224,2TSQB@28211,COG2159@1,COG2159@2 NA|NA|NA S metal-dependent hydrolase of the TIM-barrel fold MAG.T1.121_01870 886293.Sinac_6962 1.7e-176 625.9 Planctomycetes Bacteria 2IXYJ@203682,COG3391@1,COG3391@2 NA|NA|NA S amine dehydrogenase activity MAG.T1.121_01871 1088721.NSU_1615 6e-22 111.3 Alphaproteobacteria Bacteria 1RJ15@1224,2UCYU@28211,COG1432@1,COG1432@2 NA|NA|NA S NYN domain MAG.T1.121_01873 1449069.JMLO01000034_gene123 1.1e-155 556.6 Nocardiaceae 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 Bacteria 2I9IZ@201174,4G8Q1@85025,COG3119@1,COG3119@2 NA|NA|NA P Sulfatase MAG.T1.121_01875 477641.MODMU_4191 1.4e-113 416.8 Frankiales 3.5.2.2 ko:K01464 ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100 M00046 R02269,R03055,R08227 RC00632,RC00680 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GK4A@201174,4EV6E@85013,COG0044@1,COG0044@2 NA|NA|NA F PFAM amidohydrolase MAG.T1.121_01876 1123226.KB899301_gene2825 3.4e-69 268.1 Paenibacillaceae sodA GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004784,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009266,GO:0009268,GO:0009408,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0010038,GO:0010269,GO:0010447,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0030145,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071241,GO:0071248,GO:0071291,GO:0071450,GO:0071451,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 ko00000,ko00001,ko01000 iE2348C_1286.E2348C_4213,iECSF_1327.ECSF_3769 Bacteria 1TPXT@1239,26QNA@186822,4HA6U@91061,COG0605@1,COG0605@2 NA|NA|NA P Destroys radicals which are normally produced within the cells and which are toxic to biological systems MAG.T1.121_01878 479434.Sthe_0248 4.1e-96 358.2 Thermomicrobia aroF1 2.5.1.54 ko:K01626,ko:K03856 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 Bacteria 27XVV@189775,2G643@200795,COG2876@1,COG2876@2 NA|NA|NA E NeuB family MAG.T1.121_01879 479434.Sthe_1974 6.4e-151 541.2 Thermomicrobia selB ko:K03833 ko00000,ko03012 Bacteria 27XRW@189775,2G5JX@200795,COG3276@1,COG3276@2 NA|NA|NA J Elongation factor SelB, winged helix MAG.T1.121_01880 479434.Sthe_1973 4.4e-40 171.8 Thermomicrobia Bacteria 27YAS@189775,2G6YU@200795,COG2120@1,COG2120@2 NA|NA|NA S GlcNAc-PI de-N-acetylase MAG.T1.121_01882 479434.Sthe_0646 1.7e-60 239.2 Thermomicrobia ko:K09967 ko00000 Bacteria 27XW9@189775,2GB7V@200795,COG3665@1,COG3665@2 NA|NA|NA S Domain of unknown function (DUF1989) MAG.T1.121_01884 1205910.B005_3526 4.2e-31 143.3 Streptosporangiales ko:K02035 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 2GNKN@201174,4EGG4@85012,COG0747@1,COG0747@2 NA|NA|NA E Bacterial extracellular solute-binding proteins, family 5 Middle MAG.T1.121_01885 479434.Sthe_1953 4e-170 604.7 Thermomicrobia otsA 2.4.1.15,2.4.1.347,3.1.3.12 ko:K00697,ko:K16055 ko00500,ko01100,map00500,map01100 R02737,R02778 RC00005,RC00017,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 GT20 Bacteria 27XTV@189775,2G6F8@200795,COG0380@1,COG0380@2 NA|NA|NA G Glycosyltransferase family 20 MAG.T1.121_01886 479434.Sthe_1952 1.3e-18 99.4 Thermomicrobia Bacteria 27ZCF@189775,2GBFX@200795,COG3677@1,COG3677@2 NA|NA|NA L Transposase MAG.T1.121_01888 1123405.AUMM01000059_gene2095 2.8e-69 269.2 Bacilli solA GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016647,GO:0033554,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050131,GO:0050660,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.5.3.1 ko:K00301,ko:K02846 ko00260,ko01100,map00260,map01100 R00610 RC00060,RC00557 ko00000,ko00001,ko01000 iEC042_1314.EC042_1126 Bacteria 1TRYK@1239,4HAM4@91061,COG0665@1,COG0665@2 NA|NA|NA E COG0665 Glycine D-amino acid oxidases (deaminating) MAG.T1.121_01889 1033743.CAES01000011_gene4254 3.8e-99 367.9 Paenibacillaceae thuA Bacteria 1TPZ1@1239,26S59@186822,4HARS@91061,COG4813@1,COG4813@2 NA|NA|NA G Trehalose utilization protein MAG.T1.121_01890 1128421.JAGA01000001_gene2226 2e-88 332.8 unclassified Bacteria Bacteria 2NQDT@2323,COG0673@1,COG0673@2 NA|NA|NA S Oxidoreductase family, C-terminal alpha/beta domain MAG.T1.121_01891 1122921.KB898190_gene1516 1.2e-40 173.7 Paenibacillaceae ykuE ko:K07098 ko00000 Bacteria 1UU17@1239,26UNW@186822,4HC8Q@91061,COG1408@1,COG1408@2 NA|NA|NA S Phosphoesterase MAG.T1.121_01892 1128421.JAGA01000002_gene1145 8.8e-44 184.1 unclassified Bacteria menA GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006775,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009233,GO:0009234,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0032194,GO:0042180,GO:0042181,GO:0042362,GO:0042371,GO:0042373,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046428,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663 2.5.1.74 ko:K02548 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R05617,R06858,R10757 RC02935,RC02936,RC03264 ko00000,ko00001,ko00002,ko01000,ko01006 iECH74115_1262.ECH74115_5387,iG2583_1286.G2583_4737 Bacteria 2NPNN@2323,COG1575@1,COG1575@2 NA|NA|NA H UbiA prenyltransferase family MAG.T1.121_01895 1206731.BAGB01000167_gene904 7.4e-75 288.9 Nocardiaceae Bacteria 2GIZ1@201174,4FUTU@85025,COG0515@1,COG0515@2,COG3903@1,COG3903@2 NA|NA|NA K activity, protein serine threonine kinase activity, protein-tyrosine kinase activity, ATP binding, regulation of transcription, DNA-dependent, protein amino acid phosphorylation MAG.T1.121_01896 1128421.JAGA01000004_gene2493 1e-45 191.4 unclassified Bacteria Bacteria 2NPPZ@2323,COG0308@1,COG0308@2 NA|NA|NA E Peptidase family M1 domain MAG.T1.121_01897 479434.Sthe_2298 2e-44 185.7 Thermomicrobia MMAB 2.5.1.17 ko:K00798 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 Bacteria 27Y88@189775,2G6TB@200795,COG2096@1,COG2096@2 NA|NA|NA S Cobalamin adenosyltransferase MAG.T1.121_01898 479434.Sthe_1362 2e-67 263.1 Thermomicrobia mviM Bacteria 27ZAV@189775,2G9C5@200795,COG0673@1,COG0673@2 NA|NA|NA S Oxidoreductase family, NAD-binding Rossmann fold MAG.T1.121_01899 309801.trd_1105 0.0 1599.3 Thermomicrobia gltB GO:0003674,GO:0003824,GO:0004355,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045181,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 iBWG_1329.BWG_2914,iECDH10B_1368.ECDH10B_3387,iECDH1ME8569_1439.EcDH1_0495,iEcDH1_1363.EcDH1_0495,iPC815.YPO3557 Bacteria 27Z18@189775,2G5VK@200795,COG0067@1,COG0067@2,COG0069@1,COG0069@2,COG0070@1,COG0070@2 NA|NA|NA E GXGXG motif MAG.T1.121_01900 1382356.JQMP01000003_gene1524 6.3e-92 344.7 Thermomicrobia glnA2 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0044464,GO:0050001,GO:0071944 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 Bacteria 27XSZ@189775,2G5U2@200795,COG0174@1,COG0174@2 NA|NA|NA E glutamine synthetase MAG.T1.121_01901 357808.RoseRS_0141 1.8e-59 237.3 Chloroflexia ko:K09684 ko00000,ko03000 Bacteria 2G6MB@200795,375I0@32061,COG2508@1,COG2508@2 NA|NA|NA K Purine catabolism regulatory protein-like family MAG.T1.121_01902 266117.Rxyl_2819 4e-39 168.3 Bacteria Bacteria COG2345@1,COG2345@2 NA|NA|NA K Transcriptional regulator MAG.T1.121_01903 196162.Noca_4855 7.4e-46 190.7 Actinobacteria Bacteria 2IKMC@201174,COG1388@1,COG1388@2 NA|NA|NA M LysM domain MAG.T1.121_01904 697282.Mettu_0616 4.4e-105 388.3 Methylococcales 1.7.1.15 ko:K00362 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 Bacteria 1NR3M@1224,1RN6P@1236,1XEW5@135618,COG0446@1,COG0446@2 NA|NA|NA C Apoptosis-inducing factor, mitochondrion-associated, C-term MAG.T1.121_01905 574087.Acear_1207 1.3e-25 122.9 Clostridia ko:K09936 ko02024,map02024 ko00000,ko00001,ko02000 2.A.7.21 Bacteria 1V0FB@1239,24N62@186801,COG3238@1,COG3238@2 NA|NA|NA S Putative inner membrane exporter, YdcZ MAG.T1.121_01906 485913.Krac_2175 6.3e-22 110.2 Bacteria ko:K11477 ko00000 Bacteria COG0662@1,COG0662@2 NA|NA|NA G Cupin 2, conserved barrel domain protein MAG.T1.121_01909 479434.Sthe_0677 9.4e-171 606.7 Thermomicrobia Bacteria 27XVZ@189775,2G7Y3@200795,COG0161@1,COG0161@2 NA|NA|NA E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family MAG.T1.121_01910 631454.N177_0083 1.8e-16 92.0 Alphaproteobacteria Bacteria 1QY57@1224,2TXG6@28211,COG0479@1,COG0479@2 NA|NA|NA C 2Fe-2S iron-sulfur cluster binding domain MAG.T1.121_01911 1247963.JPHU01000004_gene593 4e-69 267.7 Alphaproteobacteria 1.1.1.14 ko:K00008 ko00040,ko00051,ko01100,map00040,map00051,map01100 M00014 R00875,R01896 RC00085,RC00102 ko00000,ko00001,ko00002,ko01000 Bacteria 1MW6Y@1224,2TSUK@28211,COG1063@1,COG1063@2 NA|NA|NA E alcohol dehydrogenase MAG.T1.121_01912 272123.Anacy_4513 7.3e-17 92.8 Nostocales higA ko:K21498 ko00000,ko02048 Bacteria 1G82A@1117,1HPMK@1161,COG3093@1,COG3093@2 NA|NA|NA K TIGRFAM addiction module antidote protein, HigA family MAG.T1.121_01913 479434.Sthe_1267 1e-129 470.3 Bacteria Bacteria COG0277@1,COG0277@2 NA|NA|NA C FAD linked oxidase domain protein MAG.T1.121_01914 1101190.ARWB01000001_gene360 3.9e-65 255.0 Methylocystaceae tam GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0030798,GO:0032259,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0051704 2.1.1.144,2.1.1.197 ko:K00598,ko:K02169 ko00780,ko01100,map00780,map01100 M00572 R09543 RC00003,RC00460 ko00000,ko00001,ko00002,ko01000 iECABU_c1320.ECABU_c17460,iSDY_1059.SDY_1625,ic_1306.c1942 Bacteria 1Q2Y3@1224,2TU5T@28211,36XMF@31993,COG4106@1,COG4106@2 NA|NA|NA S Methyltransferase domain MAG.T1.121_01915 479434.Sthe_0536 2.3e-16 92.4 Chloroflexi dinB Bacteria 2G7AU@200795,COG2318@1,COG2318@2 NA|NA|NA S PFAM DinB family protein MAG.T1.121_01916 235985.BBPN01000003_gene4688 3.1e-12 80.1 Bacteria Bacteria COG3391@1,COG3391@2 NA|NA|NA CO amine dehydrogenase activity MAG.T1.121_01918 1183438.GKIL_3827 5.5e-90 337.8 Bacteria alx GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K05794 ko00000 Bacteria COG0861@1,COG0861@2 NA|NA|NA P Integral membrane protein TerC family MAG.T1.121_01920 479434.Sthe_2353 9.8e-34 150.2 Chloroflexi adsA ko:K03088 ko00000,ko03021 Bacteria 2G6X7@200795,COG1595@1,COG1595@2 NA|NA|NA K TIGRFAM RNA polymerase sigma factor, sigma-70 family MAG.T1.121_01923 1128421.JAGA01000003_gene3459 2.5e-72 278.9 unclassified Bacteria ssuB ko:K02049,ko:K15555 ko00920,ko02010,map00920,map02010 M00188,M00436 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.16,3.A.1.17,3.A.1.17.2 Bacteria 2NPDJ@2323,COG1116@1,COG1116@2 NA|NA|NA P ATPases associated with a variety of cellular activities MAG.T1.121_01924 1128421.JAGA01000003_gene3458 3e-115 421.8 unclassified Bacteria MA20_23330 ko:K15553 ko00920,ko02010,map00920,map02010 M00436 ko00000,ko00001,ko00002,ko02000 3.A.1.17.2 Bacteria 2NQ8C@2323,COG0715@1,COG0715@2 NA|NA|NA P NMT1-like family MAG.T1.121_01925 1128421.JAGA01000003_gene3457 1e-68 266.9 unclassified Bacteria MA20_23325 ko:K02050,ko:K15554 ko00920,ko02010,map00920,map02010 M00188,M00436 ko00000,ko00001,ko00002,ko02000 3.A.1.16,3.A.1.17,3.A.1.17.2 Bacteria 2NR3N@2323,COG0600@1,COG0600@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component MAG.T1.121_01926 1123024.AUII01000006_gene4598 6.6e-48 198.0 Pseudonocardiales 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 Bacteria 2GMN4@201174,4DZ0E@85010,COG0574@1,COG0574@2,COG3848@1,COG3848@2 NA|NA|NA GT pyruvate phosphate dikinase MAG.T1.121_01927 1329516.JPST01000022_gene2586 3.1e-48 199.9 Thermoactinomycetaceae yvkC 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 Bacteria 1UYA0@1239,27CKJ@186824,4HD4S@91061,COG0574@1,COG0574@2,COG3848@1,COG3848@2 NA|NA|NA GT PEP-utilising enzyme, mobile domain MAG.T1.121_01928 1048339.KB913029_gene4512 2.7e-66 259.6 Actinobacteria yvkA GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 Bacteria 2H4H5@201174,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily MAG.T1.121_01929 1173024.KI912148_gene3044 4.5e-27 128.6 Cyanobacteria Bacteria 1GGD2@1117,COG0454@1,COG0456@2 NA|NA|NA K acetyltransferase MAG.T1.121_01930 1144275.COCOR_07429 2.7e-242 844.7 Myxococcales nadE GO:0003674,GO:0003824,GO:0003952,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016880,GO:0016884,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.5.1 ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 Bacteria 1MU9U@1224,2WIV4@28221,2YTUK@29,42N86@68525,COG0171@1,COG0171@2,COG0388@1,COG0388@2 NA|NA|NA H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source MAG.T1.121_01931 316274.Haur_1083 2.2e-27 129.8 Chloroflexia Bacteria 2G8FB@200795,377FW@32061,COG0589@1,COG0589@2,COG0745@1,COG0745@2 NA|NA|NA T Belongs to the universal stress protein A family MAG.T1.121_01932 479434.Sthe_1630 2.2e-116 425.6 Bacteria 2.6.1.16,5.3.1.8,5.3.1.9 ko:K00820,ko:K15916 ko00010,ko00030,ko00051,ko00250,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko04931,map00010,map00030,map00051,map00250,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map04931 M00001,M00004,M00114 R00768,R01819,R02739,R02740,R03321 RC00010,RC00163,RC00376,RC00563,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 Bacteria COG0449@1,COG0449@2 NA|NA|NA M glutamine-fructose-6-phosphate transaminase (isomerizing) activity MAG.T1.121_01933 479434.Sthe_1109 1.2e-43 184.1 Thermomicrobia ko:K03548 ko00000,ko02000 2.A.86.1 Bacteria 27Z3Y@189775,2G712@200795,COG0628@1,COG0628@2 NA|NA|NA S AI-2E family transporter MAG.T1.121_01934 309801.trd_1657 4.7e-48 199.1 Thermomicrobia ko:K09684 ko00000,ko03000 Bacteria 27XVG@189775,2G6MB@200795,COG2508@1,COG2508@2 NA|NA|NA QT PucR C-terminal helix-turn-helix domain MAG.T1.121_01935 479434.Sthe_2400 3e-66 258.5 Thermomicrobia ecfA ko:K16784,ko:K16786,ko:K16927 ko02010,map02010 M00581,M00582 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 Bacteria 27Y82@189775,2G6FK@200795,COG1122@1,COG1122@2 NA|NA|NA P ECF transporter, substrate-specific component MAG.T1.121_01936 661478.OP10G_3827 0.0 1423.7 Bacteria nrdJ 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 Bacteria COG0209@1,COG0209@2,COG1372@1,COG1372@2 NA|NA|NA L intein-mediated protein splicing MAG.T1.121_01937 479434.Sthe_2349 3.7e-25 121.3 Chloroflexi Bacteria 2G7HZ@200795,COG1569@1,COG1569@2 NA|NA|NA S PIN domain MAG.T1.121_01939 1205680.CAKO01000038_gene1422 5.3e-49 201.8 Bacteria ko:K07045 ko00000 Bacteria COG3618@1,COG3618@2 NA|NA|NA H amidohydrolase MAG.T1.121_01943 1380391.JIAS01000004_gene2970 2e-62 246.1 Proteobacteria 3.1.1.17 ko:K01053 ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220 M00129 R01519,R02933,R03751 RC00537,RC00983 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1RJY7@1224,COG3386@1,COG3386@2 NA|NA|NA G SMP-30/Gluconolaconase/LRE-like region MAG.T1.121_01944 411902.CLOBOL_02418 8.2e-63 247.7 Lachnoclostridium Bacteria 1UEJW@1239,222S6@1506553,25JI2@186801,COG2017@1,COG2017@2 NA|NA|NA G Domain of unknown function (DUF4432) MAG.T1.121_01945 1382356.JQMP01000003_gene2604 1.3e-129 470.3 Thermomicrobia accD GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009059,GO:0009273,GO:0009987,GO:0016020,GO:0016053,GO:0019752,GO:0032787,GO:0034645,GO:0042546,GO:0043170,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070589,GO:0071554,GO:0071704,GO:0071766,GO:0071767,GO:0071768,GO:0071840,GO:0071944,GO:0072330,GO:1901576 2.1.3.15,6.4.1.2 ko:K01962,ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 Bacteria 27XKR@189775,2G7S3@200795,COG0777@1,COG0777@2,COG0825@1,COG0825@2 NA|NA|NA I catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the MAG.T1.121_01947 357808.RoseRS_0581 1.6e-59 236.1 Chloroflexia upp GO:0003674,GO:0003824,GO:0004845,GO:0004849,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016763,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0042802,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.9 ko:K00761 ko00240,ko01100,map00240,map01100 R00966 RC00063 ko00000,ko00001,ko01000 iAF1260.b2498,iAPECO1_1312.APECO1_4071,iB21_1397.B21_02352,iBWG_1329.BWG_2262,iE2348C_1286.E2348C_2723,iEC042_1314.EC042_2699,iEC55989_1330.EC55989_2783,iECABU_c1320.ECABU_c27980,iECBD_1354.ECBD_1190,iECB_1328.ECB_02390,iECDH10B_1368.ECDH10B_2664,iECDH1ME8569_1439.ECDH1ME8569_2424,iECD_1391.ECD_02390,iECED1_1282.ECED1_2921,iECH74115_1262.ECH74115_3720,iECIAI1_1343.ECIAI1_2550,iECIAI39_1322.ECIAI39_2639,iECNA114_1301.ECNA114_2571,iECO103_1326.ECO103_3015,iECO111_1330.ECO111_3222,iECO26_1355.ECO26_3545,iECOK1_1307.ECOK1_2794,iECP_1309.ECP_2500,iECS88_1305.ECS88_2669,iECSE_1348.ECSE_2784,iECSF_1327.ECSF_2339,iECSP_1301.ECSP_3437,iECUMN_1333.ECUMN_2811,iECW_1372.ECW_m2721,iEKO11_1354.EKO11_1236,iETEC_1333.ETEC_2603,iEcDH1_1363.EcDH1_1171,iEcE24377_1341.EcE24377A_2781,iEcHS_1320.EcHS_A2633,iEcSMS35_1347.EcSMS35_2645,iEcolC_1368.EcolC_1178,iG2583_1286.G2583_3021,iJN746.PP_0746,iJO1366.b2498,iJR904.b2498,iLF82_1304.LF82_2383,iNRG857_1313.NRG857_12410,iSFV_1184.SFV_2543,iSF_1195.SF2542,iS_1188.S2691,iSbBS512_1146.SbBS512_E2872,iUMN146_1321.UM146_04235,iUMNK88_1353.UMNK88_3094,iWFL_1372.ECW_m2721,iY75_1357.Y75_RS13040,ic_1306.c3015 Bacteria 2G6CS@200795,3754Q@32061,COG0035@1,COG0035@2 NA|NA|NA F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate MAG.T1.121_01948 309801.trd_A0086 4e-20 104.4 Thermomicrobia Bacteria 27Z6P@189775,2G9U4@200795,COG0346@1,COG0346@2 NA|NA|NA E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily MAG.T1.121_01949 1118054.CAGW01000005_gene3791 2.9e-100 372.5 Paenibacillaceae 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 1TPNH@1239,26QYR@186822,4HANQ@91061,COG0001@1,COG0001@2 NA|NA|NA H Glutamate-1-semialdehyde aminotransferase MAG.T1.121_01950 665571.STHERM_c06590 8.8e-47 193.7 Spirochaetes Z012_09970 Bacteria 2J5J9@203691,COG2129@1,COG2129@2 NA|NA|NA S metallophosphoesterase MAG.T1.121_01951 1128421.JAGA01000001_gene2083 1.8e-69 269.6 unclassified Bacteria Bacteria 2NS1X@2323,COG1475@1,COG1475@2 NA|NA|NA K DNA binding MAG.T1.121_01952 1121926.AXWO01000002_gene1565 6.8e-47 194.9 Glycomycetales 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 Bacteria 2GM43@201174,4EZBQ@85014,COG1472@1,COG1472@2 NA|NA|NA G Glycosyl hydrolase family 3 N terminal domain MAG.T1.121_01953 479434.Sthe_1103 1.6e-80 307.0 Thermomicrobia Bacteria 27XS6@189775,2G77Q@200795,COG0477@1,COG2814@2 NA|NA|NA EGP MFS_1 like family MAG.T1.121_01954 479434.Sthe_2344 6.9e-102 377.5 Thermomicrobia ltaA 4.1.2.48 ko:K01620 ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 R00751,R06171 RC00312,RC00372 ko00000,ko00001,ko01000 Bacteria 27XVE@189775,2G7UV@200795,COG2008@1,COG2008@2 NA|NA|NA E Beta-eliminating lyase MAG.T1.121_01955 469383.Cwoe_4383 8.8e-46 191.0 Rubrobacteria prmA ko:K02687 ko00000,ko01000,ko03009 Bacteria 2HQK7@201174,4CS5N@84995,COG2040@1,COG2040@2,COG2264@1,COG2264@2 NA|NA|NA EJ Homocysteine S-methyltransferase MAG.T1.121_01956 406124.ACPC01000020_gene3806 1.1e-07 63.5 Bacillus sinR GO:0008150,GO:0009892,GO:0010468,GO:0010605,GO:0010629,GO:0019222,GO:0048519,GO:0050789,GO:0060255,GO:0065007 ko:K19449 ko00000,ko03000 Bacteria 1VAXE@1239,1ZHZH@1386,4HKHB@91061,COG1396@1,COG1396@2 NA|NA|NA K transcriptional MAG.T1.121_01957 309801.trd_A0071 2.1e-16 91.7 Chloroflexi Bacteria 2G9BQ@200795,COG1359@1,COG1359@2 NA|NA|NA S Antibiotic biosynthesis monooxygenase MAG.T1.121_01958 525904.Tter_1437 1.5e-91 342.8 unclassified Bacteria proC 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 Bacteria 2NPIR@2323,COG0345@1,COG0345@2 NA|NA|NA E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline MAG.T1.121_01959 266117.Rxyl_2540 2e-190 672.5 Rubrobacteria yyaL ko:K06888 ko00000 Bacteria 2GJ88@201174,4CPJ8@84995,COG1331@1,COG1331@2 NA|NA|NA O Protein of unknown function, DUF255 MAG.T1.121_01960 309801.trd_A0348 2.3e-67 262.3 Thermomicrobia hpcE Bacteria 27XWZ@189775,2G6H8@200795,COG0179@1,COG0179@2 NA|NA|NA Q Fumarylacetoacetate (FAA) hydrolase family MAG.T1.121_01961 479434.Sthe_0308 4.7e-110 404.4 Thermomicrobia ilvE 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 27XJA@189775,2GAM4@200795,COG0115@1,COG0115@2 NA|NA|NA E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family MAG.T1.121_01962 479434.Sthe_0309 1.8e-107 396.7 Thermomicrobia ko:K02035,ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 27XKE@189775,2G8A0@200795,COG4166@1,COG4166@2 NA|NA|NA E PFAM extracellular solute-binding protein family 5 MAG.T1.121_01963 1521187.JPIM01000028_gene1610 2.3e-110 405.6 Chloroflexia MA20_20675 ko:K02032,ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 2G5R5@200795,3750H@32061,COG4608@1,COG4608@2 NA|NA|NA P Belongs to the ABC transporter superfamily MAG.T1.121_01964 479434.Sthe_0388 1.1e-110 406.8 Thermomicrobia oppD ko:K02031,ko:K02032,ko:K15583 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 27XUE@189775,2G61B@200795,COG0444@1,COG0444@2 NA|NA|NA P Belongs to the ABC transporter superfamily MAG.T1.121_01965 309801.trd_A0324 1.5e-77 296.6 Thermomicrobia ko:K02034,ko:K15582 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 27XHC@189775,2G612@200795,COG1173@1,COG1173@2 NA|NA|NA EP N-terminal TM domain of oligopeptide transport permease C MAG.T1.121_01966 479434.Sthe_1894 1.7e-83 316.2 Thermomicrobia ko:K02033 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 iLJ478.TM1747 Bacteria 27XMA@189775,2G61A@200795,COG0601@1,COG0601@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component MAG.T1.121_01967 479434.Sthe_0312 3.5e-144 518.5 Thermomicrobia hslU GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019904,GO:0022607,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043335,GO:0043933,GO:0044085,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1904949,GO:1905368,GO:1905369 ko:K03667 ko00000,ko03110 Bacteria 27XKZ@189775,2GBH6@200795,COG1220@1,COG1220@2 NA|NA|NA O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis MAG.T1.121_01968 479434.Sthe_0313 8.8e-59 233.4 Thermomicrobia hslV GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016787,GO:0017076,GO:0019538,GO:0019904,GO:0022607,GO:0030163,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0051603,GO:0065003,GO:0070003,GO:0070011,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 3.4.25.2 ko:K01419 ko00000,ko01000,ko01002 Bacteria 27Y6T@189775,2GA07@200795,COG5405@1,COG5405@2 NA|NA|NA O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery MAG.T1.121_01969 479434.Sthe_0383 2.9e-264 917.9 Thermomicrobia topA GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360 5.99.1.2 ko:K03168 ko00000,ko01000,ko03032,ko03400 Bacteria 27XYG@189775,2G5ZR@200795,COG0550@1,COG0550@2 NA|NA|NA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone MAG.T1.121_01970 479434.Sthe_0385 1.3e-93 350.1 Thermomicrobia dprA 2.7.7.7,5.99.1.2 ko:K02342,ko:K03168,ko:K03703,ko:K04096 ko00230,ko00240,ko01100,ko03030,ko03420,ko03430,ko03440,map00230,map00240,map01100,map03030,map03420,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 27XEI@189775,2G5UA@200795,COG0322@1,COG0322@2,COG0758@1,COG0758@2 NA|NA|NA LU DNA recombination-mediator protein A MAG.T1.121_01971 479434.Sthe_1844 1.4e-84 320.1 Thermomicrobia spoIVFB GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K06212,ko:K06402 ko00000,ko01000,ko01002,ko02000 1.A.16.1.1,1.A.16.1.3 Bacteria 27XT5@189775,2G719@200795,COG0517@1,COG0517@2,COG1994@1,COG1994@2 NA|NA|NA S Belongs to the peptidase M50B family MAG.T1.121_01972 1382356.JQMP01000004_gene639 3.3e-45 188.0 Thermomicrobia Bacteria 27YCQ@189775,2G8ZH@200795,COG1959@1,COG1959@2 NA|NA|NA K Transcriptional regulator MAG.T1.121_01973 309801.trd_1634 1.2e-118 433.3 Thermomicrobia iscS 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 Bacteria 27XYX@189775,2G63V@200795,COG1104@1,COG1104@2 NA|NA|NA E Beta-eliminating lyase MAG.T1.121_01974 926569.ANT_11700 1.1e-34 153.7 Chloroflexi scpB ko:K06024 ko00000,ko03036 Bacteria 2G6V6@200795,COG1386@1,COG1386@2 NA|NA|NA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves MAG.T1.121_01975 479434.Sthe_0392 2.1e-31 142.9 Thermomicrobia scpA ko:K05896 ko00000,ko03036 Bacteria 27YPU@189775,2G6WU@200795,COG1354@1,COG1354@2 NA|NA|NA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves MAG.T1.121_01976 479434.Sthe_0391 3.5e-25 121.7 Chloroflexi rny ko:K18682 ko03018,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 2G7CI@200795,COG1418@1,COG1418@2 NA|NA|NA S mRNA catabolic process MAG.T1.121_01977 479434.Sthe_0390 7.7e-47 194.1 Thermomicrobia Bacteria 27Y97@189775,2G6VM@200795,COG1994@1,COG1994@2 NA|NA|NA S Peptidase M50 MAG.T1.121_01978 479434.Sthe_0389 1.2e-46 192.2 Thermomicrobia ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 27XY8@189775,2G5R5@200795,COG4608@1,COG4608@2 NA|NA|NA P Belongs to the ABC transporter superfamily MAG.T1.121_01981 357808.RoseRS_3797 3.7e-95 355.5 Bacteria Bacteria COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily MAG.T1.121_01982 1173027.Mic7113_4763 1.9e-16 92.4 Oscillatoriales Bacteria 1G6R8@1117,1HBTJ@1150,2CIIF@1,315FB@2 NA|NA|NA MAG.T1.121_01983 479434.Sthe_3501 2.6e-206 724.9 Thermomicrobia putA 1.2.1.88,1.5.5.2 ko:K00294,ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 iAF987.Gmet_3512 Bacteria 27Y57@189775,2G5JZ@200795,COG1012@1,COG1012@2 NA|NA|NA C Belongs to the aldehyde dehydrogenase family MAG.T1.121_01984 649638.Trad_2650 1.1e-57 229.9 Bacteria ko:K06999,ko:K15975 ko00000 Bacteria COG0400@1,COG0400@2 NA|NA|NA S palmitoyl-(protein) hydrolase activity MAG.T1.121_01985 1321778.HMPREF1982_01029 4.4e-30 139.4 Clostridia Bacteria 1V6AW@1239,24EU8@186801,COG0726@1,COG0726@2 NA|NA|NA G PFAM Polysaccharide deacetylase MAG.T1.121_01986 479434.Sthe_1731 2.8e-24 119.4 Thermomicrobia CP_0328 Bacteria 27YJA@189775,2G7DZ@200795,COG1664@1,COG1664@2 NA|NA|NA M Polymer-forming cytoskeletal MAG.T1.121_01987 479434.Sthe_1732 7.2e-18 97.4 Thermomicrobia Bacteria 27YJF@189775,2GA19@200795,COG1664@1,COG1664@2 NA|NA|NA M Polymer-forming cytoskeletal MAG.T1.121_01988 1382356.JQMP01000003_gene2249 1e-30 141.0 Thermomicrobia 3.4.21.96 ko:K01361 ko00000,ko01000,ko01002,ko03110 Bacteria 27Y7F@189775,2G9S1@200795,COG3103@1,COG3103@2 NA|NA|NA T Bacterial SH3 domain homologues MAG.T1.121_01989 479434.Sthe_1734 5.5e-78 297.7 Thermomicrobia rpsB GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02967 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 27XHX@189775,2G5J2@200795,COG0052@1,COG0052@2 NA|NA|NA J Belongs to the universal ribosomal protein uS2 family MAG.T1.121_01990 1382356.JQMP01000003_gene2247 9.6e-50 203.4 Thermomicrobia tsf GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0030312,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02357 ko00000,ko03012,ko03029 Bacteria 27Y81@189775,2G6MJ@200795,COG0264@1,COG0264@2 NA|NA|NA J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome MAG.T1.121_01991 309801.trd_1000 8.5e-91 340.1 Thermomicrobia pyrH GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006225,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009163,GO:0009165,GO:0009185,GO:0009188,GO:0009193,GO:0009194,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0033862,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042455,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046048,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046872,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 R00158 RC00002 ko00000,ko00001,ko01000 iSB619.SA_RS06240 Bacteria 27XHK@189775,2G5RG@200795,COG0528@1,COG0528@2 NA|NA|NA F Catalyzes the reversible phosphorylation of UMP to UDP MAG.T1.121_01992 479434.Sthe_1737 1.9e-58 232.3 Thermomicrobia frr GO:0002181,GO:0002184,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0030312,GO:0032984,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02838 ko00000,ko03012 Bacteria 27Y79@189775,2G6FY@200795,COG0233@1,COG0233@2 NA|NA|NA J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another MAG.T1.121_01993 479434.Sthe_1738 1.1e-88 333.2 Thermomicrobia uppS GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617 2.5.1.31,2.5.1.68 ko:K00806,ko:K12503 ko00900,ko01110,map00900,map01110 R06447,R08528 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 Bacteria 27XF1@189775,2G65C@200795,COG0020@1,COG0020@2 NA|NA|NA H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids MAG.T1.121_01994 309801.trd_1003 2.5e-33 149.4 Thermomicrobia cdsA 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 27YD8@189775,2G6QV@200795,COG4589@1,COG4589@2 NA|NA|NA M Cytidylyltransferase family MAG.T1.121_01995 479434.Sthe_1740 1.5e-100 373.2 Thermomicrobia dxr GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0050897,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 iAPECO1_1312.APECO1_1814,iECOK1_1307.ECOK1_0174,iECS88_1305.ECS88_0183,iHN637.CLJU_RS06420,iNJ661.Rv2870c,iUMN146_1321.UM146_23670,iUTI89_1310.UTI89_C0188 Bacteria 27Y4B@189775,2G5RB@200795,COG0743@1,COG0743@2 NA|NA|NA I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) MAG.T1.121_01996 479434.Sthe_0523 1.3e-32 146.7 Thermomicrobia ComFC Bacteria 27YJE@189775,2G6WB@200795,COG1040@1,COG1040@2 NA|NA|NA S competence protein MAG.T1.121_01997 533240.CRC_01718 5.3e-105 388.3 Nostocales 3.5.4.28,3.5.4.31 ko:K12960 ko00270,ko01100,map00270,map01100 R09660 RC00477 ko00000,ko00001,ko01000 Bacteria 1GCK3@1117,1HS6K@1161,COG0402@1,COG0402@2 NA|NA|NA F Amidohydrolase family MAG.T1.121_01998 1120963.KB894499_gene492 4.5e-24 118.2 Pseudoalteromonadaceae mobC Bacteria 1RD57@1224,1S42W@1236,2Q4V1@267888,COG0454@1,COG0456@2 NA|NA|NA K FR47-like protein MAG.T1.121_02001 1385518.N798_07215 1.2e-22 112.1 Intrasporangiaceae Bacteria 2EJF2@1,2GSWN@201174,33D61@2,4FJHQ@85021 NA|NA|NA MAG.T1.121_02002 479434.Sthe_2353 4.9e-22 111.3 Chloroflexi adsA ko:K03088 ko00000,ko03021 Bacteria 2G6X7@200795,COG1595@1,COG1595@2 NA|NA|NA K TIGRFAM RNA polymerase sigma factor, sigma-70 family MAG.T1.121_02003 1227457.C451_02869 6.6e-18 99.8 Halobacteria Archaea 23SYZ@183963,2Y7Q0@28890,COG1520@1,arCOG02492@2157 NA|NA|NA M COG1520 FOG WD40-like repeat MAG.T1.121_02005 1382356.JQMP01000003_gene1646 1.4e-28 132.9 Thermomicrobia Bacteria 27YHV@189775,2G9QC@200795,COG4243@1,COG4243@2 NA|NA|NA S VKc MAG.T1.121_02006 309801.trd_A0141 9.3e-50 203.8 Thermomicrobia bdbD Bacteria 27YB4@189775,2G8TG@200795,COG1651@1,COG1651@2 NA|NA|NA O DSBA-like thioredoxin domain MAG.T1.121_02009 864702.OsccyDRAFT_4324 5.6e-95 354.8 Bacteria Bacteria COG1073@1,COG1073@2 NA|NA|NA S thiolester hydrolase activity MAG.T1.121_02010 330214.NIDE3513 1.1e-82 313.5 Bacteria Bacteria COG0667@1,COG0667@2 NA|NA|NA C Aldo Keto reductase MAG.T1.121_02011 663610.JQKO01000012_gene3128 1.3e-07 63.5 Alphaproteobacteria Bacteria 1RADI@1224,2E61I@1,2U5E9@28211,330QS@2 NA|NA|NA MAG.T1.121_02012 266117.Rxyl_2878 2.1e-44 185.3 Rubrobacteria arsC 1.20.4.1 ko:K03741 ko00000,ko01000 Bacteria 2HEP3@201174,4CTHA@84995,COG0394@1,COG0394@2 NA|NA|NA T low molecular weight phosphotyrosine protein phosphatase MAG.T1.121_02014 1242864.D187_001221 7.1e-129 467.2 Myxococcales arsB GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015104,GO:0015105,GO:0015291,GO:0015297,GO:0015318,GO:0015698,GO:0015699,GO:0015700,GO:0016020,GO:0022804,GO:0022857,GO:0034220,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656 ko:K03325 ko00000,ko02000 2.A.59 iYO844.BSU25790 Bacteria 1MUXY@1224,2WK36@28221,2Z0TJ@29,42M0Z@68525,COG0798@1,COG0798@2 NA|NA|NA P arsenical-resistance protein MAG.T1.121_02015 1122962.AULH01000045_gene3920 2.1e-80 305.8 Methylocystaceae arsM 2.1.1.137 ko:K07755 ko00000,ko01000 Bacteria 1MVXN@1224,2TR8A@28211,3719Y@31993,COG0500@1,COG2226@2 NA|NA|NA Q ubiE/COQ5 methyltransferase family MAG.T1.121_02016 110319.CF8_2002 2.7e-18 98.2 Propionibacteriales ko:K03892 ko00000,ko03000 Bacteria 2IQDH@201174,4DRFG@85009,COG0640@1,COG0640@2 NA|NA|NA K helix_turn_helix, Arsenical Resistance Operon Repressor MAG.T1.121_02017 1407650.BAUB01000010_gene1990 3.2e-23 115.2 Synechococcus Bacteria 1G8HF@1117,1H303@1129,COG1917@1,COG1917@2 NA|NA|NA S Cupin 2, conserved barrel domain protein MAG.T1.121_02019 479434.Sthe_0485 2e-72 280.8 Thermomicrobia ko:K15773 ko00000,ko02048,ko03000 Bacteria 27ZD0@189775,2G7W3@200795,COG0457@1,COG0457@2,COG1396@1,COG1396@2,COG3903@1,COG3903@2 NA|NA|NA K Tetratricopeptide repeat MAG.T1.121_02020 269799.Gmet_3525 4.3e-16 90.5 Desulfuromonadales 2.8.1.7,4.4.1.16 ko:K03980,ko:K11717 ko00450,ko01100,map00450,map01100 R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000,ko01011,ko02000 2.A.66.4 Bacteria 1RDC1@1224,2WTX3@28221,42UDQ@68525,43SY3@69541,COG3266@1,COG3266@2 NA|NA|NA S domain, Protein MAG.T1.121_02021 525904.Tter_0169 2.2e-73 282.7 unclassified Bacteria ubiA Bacteria 2NNVJ@2323,COG0382@1,COG0382@2 NA|NA|NA H UbiA prenyltransferase family MAG.T1.121_02022 1329516.JPST01000008_gene2000 1.4e-76 293.5 Thermoactinomycetaceae pyrD GO:0000166,GO:0003674,GO:0003824,GO:0004152,GO:0004158,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0010181,GO:0016020,GO:0016491,GO:0016627,GO:0016634,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0032553,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.5.2 ko:K00254,ko:K02823,ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01868,R01869 RC00051 ko00000,ko00001,ko00002,ko01000 iEC042_1314.EC042_1029,iECIAI39_1322.ECIAI39_2202,iECUMN_1333.ECUMN_1134,iEcSMS35_1347.EcSMS35_2174,iPC815.YPO1415,iYL1228.KPN_00974 Bacteria 1TPFV@1239,27BB8@186824,4HBKN@91061,COG0167@1,COG0167@2 NA|NA|NA F Dihydroorotate dehydrogenase MAG.T1.121_02023 309801.trd_0463 6e-211 740.3 Thermomicrobia MA20_01895 Bacteria 27Y46@189775,2G5SE@200795,COG1233@1,COG1233@2 NA|NA|NA Q Flavin containing amine oxidoreductase MAG.T1.121_02024 1122182.KB903834_gene5852 2e-14 85.9 Micromonosporales Bacteria 2AYS8@1,2IT4P@201174,31QXE@2,4DF45@85008 NA|NA|NA MAG.T1.121_02025 309801.trd_1960 4.5e-42 179.1 Thermomicrobia enhA_2 Bacteria 27XVB@189775,2G6ZY@200795,COG1376@1,COG1376@2,COG5479@1,COG5479@2 NA|NA|NA M L,D-transpeptidase catalytic domain MAG.T1.121_02026 479434.Sthe_1383 2.5e-85 323.2 Thermomicrobia recJ ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 27XQQ@189775,2G5US@200795,COG0608@1,COG0608@2 NA|NA|NA L DHH family MAG.T1.121_02027 479434.Sthe_0093 2.2e-292 1011.5 Thermomicrobia lon GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004175,GO:0004176,GO:0004252,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009408,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0017171,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051603,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.4.21.53 ko:K01338 ko04112,map04112 ko00000,ko00001,ko01000,ko01002 Bacteria 27YSH@189775,2G7KC@200795,COG0466@1,COG0466@2 NA|NA|NA O ATP-dependent protease La (LON) substrate-binding domain MAG.T1.121_02028 1128421.JAGA01000001_gene2048 1.2e-74 286.6 unclassified Bacteria yvdD_2 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 Bacteria 2NP7M@2323,COG1611@1,COG1611@2 NA|NA|NA S Possible lysine decarboxylase MAG.T1.121_02031 1382356.JQMP01000003_gene1897 9.8e-44 183.7 Thermomicrobia ko:K09164 ko00000 Bacteria 27Z2J@189775,2G9CX@200795,COG3358@1,COG3358@2 NA|NA|NA S Protein of unknown function (DUF1684) MAG.T1.121_02032 370438.PTH_0922 2.8e-56 225.7 Peptococcaceae murI GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0030203,GO:0034645,GO:0036361,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0047661,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 R00260 RC00302 ko00000,ko00001,ko01000,ko01011 Bacteria 1TPPR@1239,249MB@186801,2624I@186807,COG0796@1,COG0796@2 NA|NA|NA M Provides the (R)-glutamate required for cell wall biosynthesis MAG.T1.121_02033 1449126.JQKL01000006_gene737 3.7e-26 125.9 unclassified Clostridiales Bacteria 1TRYQ@1239,24966@186801,26BAW@186813,COG2006@1,COG2006@2 NA|NA|NA S Domain of unknown function (DUF362) MAG.T1.121_02034 1123023.JIAI01000007_gene1771 5.8e-19 101.3 Pseudonocardiales Bacteria 2I66K@201174,4E76K@85010,COG1878@1,COG1878@2 NA|NA|NA S Putative cyclase MAG.T1.121_02036 479434.Sthe_2689 1e-168 599.7 Thermomicrobia adhfe 1.1.1.1,1.1.99.24 ko:K00001,ko:K11173 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 Bacteria 27YUC@189775,2G6IU@200795,COG1454@1,COG1454@2 NA|NA|NA C Iron-containing alcohol dehydrogenase MAG.T1.121_02037 869210.Marky_0902 1.9e-58 233.0 Bacteria 3.2.1.26 ko:K01193 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00801,R00802,R02410,R03635,R03921,R06088 RC00028,RC00077 ko00000,ko00001,ko01000 GH32 Bacteria COG1621@1,COG1621@2 NA|NA|NA G Belongs to the glycosyl hydrolase 32 family MAG.T1.121_02038 479434.Sthe_2889 6.2e-211 740.7 Thermomicrobia oplaH 3.5.2.14,3.5.2.9 ko:K01469,ko:K01473 ko00330,ko00480,ko01100,map00330,map00480,map01100 R00251,R03187 RC00553,RC00632 ko00000,ko00001,ko01000 Bacteria 27XUM@189775,2G5KZ@200795,COG0145@1,COG0145@2 NA|NA|NA EQ Hydantoinaseoxoprolinase domain protein MAG.T1.121_02040 479434.Sthe_2890 7.7e-185 653.7 Thermomicrobia MA20_04180 3.5.2.14,3.5.2.9 ko:K01469,ko:K01474 ko00330,ko00480,ko01100,map00330,map00480,map01100 R00251,R03187 RC00553,RC00632 ko00000,ko00001,ko01000 Bacteria 27XUU@189775,2G644@200795,COG0146@1,COG0146@2 NA|NA|NA EQ PFAM Hydantoinase B oxoprolinase MAG.T1.121_02041 309801.trd_A0543 7.9e-75 287.3 Thermomicrobia mvaB GO:0000287,GO:0003674,GO:0003824,GO:0004419,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005777,GO:0005782,GO:0005829,GO:0006082,GO:0006091,GO:0006520,GO:0006551,GO:0006552,GO:0006605,GO:0006625,GO:0006629,GO:0006807,GO:0006810,GO:0006886,GO:0006996,GO:0007031,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009063,GO:0009081,GO:0009083,GO:0009987,GO:0015031,GO:0015833,GO:0016043,GO:0016054,GO:0016829,GO:0016830,GO:0016833,GO:0017144,GO:0019752,GO:0022607,GO:0030145,GO:0031907,GO:0031974,GO:0033036,GO:0033365,GO:0034613,GO:0042579,GO:0042802,GO:0042803,GO:0042886,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043574,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0046395,GO:0046872,GO:0046907,GO:0046914,GO:0046950,GO:0046951,GO:0046983,GO:0051179,GO:0051234,GO:0051259,GO:0051262,GO:0051641,GO:0051649,GO:0065003,GO:0070013,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0072594,GO:0072662,GO:0072663,GO:1901564,GO:1901565,GO:1901568,GO:1901570,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1902224 4.1.3.4,6.4.1.4 ko:K01640,ko:K01968 ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146 M00036,M00088 R01360,R04138,R08090 RC00367,RC00502,RC00503,RC00942,RC01118,RC01946 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_3293 Bacteria 27YV0@189775,2G7M0@200795,COG0119@1,COG0119@2 NA|NA|NA E HMGL-like MAG.T1.121_02042 1128421.JAGA01000003_gene3007 3.8e-33 148.7 Bacteria Bacteria COG2227@1,COG2227@2 NA|NA|NA H 3-demethylubiquinone-9 3-O-methyltransferase activity MAG.T1.121_02043 1499967.BAYZ01000058_gene4762 3.5e-98 365.2 unclassified Bacteria frvX 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 R06200,R11307,R11308 ko00000,ko00001,ko01000 GH5,GH9 Bacteria 2NQGB@2323,COG1363@1,COG1363@2 NA|NA|NA G M42 glutamyl aminopeptidase MAG.T1.121_02044 479434.Sthe_3166 3.3e-49 202.2 Thermomicrobia fpg 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 27YXH@189775,2G6BB@200795,COG0266@1,COG0266@2 NA|NA|NA L Formamidopyrimidine-DNA glycosylase H2TH domain MAG.T1.121_02046 1229780.BN381_100064 1.6e-21 109.0 Bacteria ko:K09705 ko00000 Bacteria COG3502@1,COG3502@2 NA|NA|NA S Protein of unknown function (DUF952) MAG.T1.121_02047 479434.Sthe_0838 6e-98 364.4 Thermomicrobia selD 2.7.9.3 ko:K01008 ko00450,ko01100,map00450,map01100 R03595 RC00002,RC02878 ko00000,ko00001,ko01000,ko03016 Bacteria 27XGA@189775,2G5W4@200795,COG0709@1,COG0709@2 NA|NA|NA H Synthesizes selenophosphate from selenide and ATP MAG.T1.121_02048 555079.Toce_2266 3.7e-40 172.2 Clostridia Bacteria 1TQJH@1239,24BHT@186801,COG1597@1,COG1597@2 NA|NA|NA I lipid kinase, YegS Rv2252 BmrU family MAG.T1.121_02049 479434.Sthe_0837 9.4e-62 243.8 Thermomicrobia ksgA GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 ko:K02528 R10716 RC00003,RC03257 ko00000,ko01000,ko03009 Bacteria 27XUP@189775,2G6DA@200795,COG0030@1,COG0030@2 NA|NA|NA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits MAG.T1.121_02050 479434.Sthe_0836 7e-39 167.9 Thermomicrobia ispE GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0040007,GO:0044237,GO:0050515 2.1.1.182,2.7.1.148 ko:K00919,ko:K02528,ko:K16924 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096,M00582 R05634,R10716 RC00002,RC00003,RC01439,RC03257 ko00000,ko00001,ko00002,ko01000,ko02000,ko03009 3.A.1.29 iYO844.BSU00460 Bacteria 27Y5K@189775,2G71D@200795,COG1947@1,COG1947@2 NA|NA|NA H Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol MAG.T1.121_02051 479434.Sthe_0833 6.6e-22 111.7 Thermomicrobia 2.7.11.1 ko:K08884,ko:K12132 ko00000,ko01000,ko01001 Bacteria 27XI6@189775,2G67H@200795,COG0515@1,COG0515@2,COG2815@1,COG2815@2 NA|NA|NA T Protein kinase domain MAG.T1.121_02053 479434.Sthe_0830 1.7e-133 482.6 Chloroflexi ko:K01436 ko00000,ko01000,ko01002 Bacteria 2G7D3@200795,COG1473@1,COG1473@2 NA|NA|NA S peptidase dimerisation domain protein MAG.T1.121_02054 309801.trd_0045 1.1e-07 64.3 Thermomicrobia cvpA ko:K03558 ko00000 Bacteria 27Y7E@189775,2G9FV@200795,COG1286@1,COG1286@2 NA|NA|NA S Colicin V production protein MAG.T1.121_02057 525904.Tter_2700 7.1e-48 198.4 unclassified Bacteria 1.1.1.18,1.1.1.369 ko:K00010 ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130 R01183,R09951 RC00182 ko00000,ko00001,ko01000 Bacteria 2NRRS@2323,COG0673@1,COG0673@2 NA|NA|NA S Oxidoreductase family, NAD-binding Rossmann fold MAG.T1.121_02059 1382356.JQMP01000003_gene1830 2.1e-127 462.6 Thermomicrobia Bacteria 27XWR@189775,2G62C@200795,COG0624@1,COG0624@2 NA|NA|NA E peptidase M20 MAG.T1.121_02061 309801.trd_1345 7.7e-65 254.2 Thermomicrobia Bacteria 27Y7R@189775,2G8CA@200795,COG2141@1,COG2141@2 NA|NA|NA C Luciferase-like monooxygenase MAG.T1.121_02062 1118054.CAGW01000033_gene4061 2.4e-67 262.7 Paenibacillaceae hprA 1.1.1.28,1.1.1.399,1.1.1.95 ko:K00058,ko:K03778 ko00260,ko00620,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00620,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R00704,R01513 RC00031,RC00044 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1TQ7W@1239,26WIR@186822,4HDEC@91061,COG0111@1,COG0111@2 NA|NA|NA EH D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain MAG.T1.121_02063 479434.Sthe_0609 5.9e-43 181.0 Thermomicrobia ko:K03088 ko00000,ko03021 Bacteria 27YI4@189775,2G6MG@200795,COG1595@1,COG1595@2 NA|NA|NA K Sigma-70, region 4 MAG.T1.121_02065 926569.ANT_30480 1.5e-29 136.7 Chloroflexi lpqG ko:K09807 ko00000 Bacteria 2G6UC@200795,COG2968@1,COG2968@2 NA|NA|NA S Protein of unknown function (DUF541) MAG.T1.121_02066 266265.Bxe_B2137 2.2e-40 172.9 Burkholderiaceae MA20_20600 1.14.17.3 ko:K00504 ko00000,ko01000 Bacteria 1K8PQ@119060,1NT97@1224,2VZU1@28216,COG3391@1,COG3391@2 NA|NA|NA S PFAM NHL repeat containing protein MAG.T1.121_02067 479434.Sthe_0613 6.5e-34 151.4 Thermomicrobia Bacteria 27Y5E@189775,2GAAF@200795,COG2897@1,COG2897@2 NA|NA|NA P Rhodanese Homology Domain MAG.T1.121_02068 926560.KE387026_gene4201 2.6e-12 80.9 Bacteria Bacteria 28XGZ@1,2ZJEE@2 NA|NA|NA MAG.T1.121_02071 566461.SSFG_07465 1.2e-44 186.0 Actinobacteria ko:K04750 ko00000 Bacteria 2IKY5@201174,COG2764@1,COG2764@2 NA|NA|NA S glyoxalase bleomycin resistance protein dioxygenase MAG.T1.121_02072 479434.Sthe_1400 2e-67 262.7 Thermomicrobia 1.2.5.3 ko:K03519 R11168 RC02800 ko00000,ko01000 Bacteria 27XP9@189775,2G60Y@200795,COG1319@1,COG1319@2 NA|NA|NA C CO dehydrogenase flavoprotein C-terminal domain MAG.T1.121_02073 1521187.JPIM01000062_gene2429 0.0 1108.2 Chloroflexia coxL 1.2.5.3 ko:K03520 R11168 RC02800 ko00000,ko01000 Bacteria 2G608@200795,376SU@32061,COG1529@1,COG1529@2 NA|NA|NA C PFAM aldehyde oxidase and xanthine dehydrogenase, a b hammerhead MAG.T1.121_02074 1122222.AXWR01000004_gene1702 2.4e-65 255.0 Deinococcus-Thermus coxS 1.2.5.3,1.3.99.16 ko:K03518,ko:K07302 R11168 RC02800 ko00000,ko01000 Bacteria 1WK3N@1297,COG2080@1,COG2080@2 NA|NA|NA C COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs MAG.T1.121_02075 1382356.JQMP01000001_gene1057 1.8e-72 280.0 Thermomicrobia Bacteria 27YUW@189775,2G6D7@200795,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator superfamily MFS_1 MAG.T1.121_02077 479434.Sthe_1009 1.4e-170 606.3 Thermomicrobia ilvB1 2.2.1.6,4.1.1.75 ko:K01652,ko:K12253 ko00290,ko00330,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00330,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R03178,R04672,R04673,R08648 RC00027,RC00106,RC00506,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 Bacteria 27Y11@189775,2G810@200795,COG0028@1,COG0028@2 NA|NA|NA EH Belongs to the TPP enzyme family MAG.T1.121_02080 1499967.BAYZ01000086_gene5150 1.9e-18 100.9 unclassified Bacteria Bacteria 2NS0B@2323,COG1807@1,COG1807@2 NA|NA|NA M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family MAG.T1.121_02081 1198232.CYCME_1453 3.6e-120 438.7 Gammaproteobacteria Bacteria 1QX3T@1224,1T3RT@1236,COG1232@1,COG1232@2 NA|NA|NA H Flavin containing amine oxidoreductase MAG.T1.121_02082 694440.JOMF01000008_gene1047 2.6e-15 88.6 Archaea 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 R01009 RC00005 ko00000,ko00001,ko01000,ko01003 GT2 Archaea COG0463@1,arCOG00894@2157 NA|NA|NA M PFAM Glycosyl transferase family 2 MAG.T1.121_02083 1382356.JQMP01000004_gene534 1.6e-74 287.0 Thermomicrobia 3.4.21.102 ko:K03797 ko00000,ko01000,ko01002 Bacteria 27Y0X@189775,2G6A8@200795,COG0793@1,COG0793@2 NA|NA|NA M Belongs to the peptidase S41A family MAG.T1.121_02085 1128421.JAGA01000002_gene1675 3.2e-18 98.2 unclassified Bacteria rutC 4.2.99.21 ko:K04782 ko01053,ko01110,ko01130,map01053,map01110,map01130 R06602 RC01549,RC02148 ko00000,ko00001,ko01000 Bacteria 2NR4K@2323,COG0251@1,COG0251@2 NA|NA|NA J Endoribonuclease L-PSP MAG.T1.121_02086 330214.NIDE0050 2e-28 132.1 Bacteria Bacteria COG0251@1,COG0251@2 NA|NA|NA J oxidation-reduction process MAG.T1.121_02087 1122132.AQYH01000006_gene3548 2.3e-60 238.8 Rhizobiaceae ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 ko00000,ko00001,ko00002,ko02000 3.A.1.1 Bacteria 1R707@1224,2U30B@28211,4B9VF@82115,COG3842@1,COG3842@2 NA|NA|NA P TOBE domain MAG.T1.121_02088 1340493.JNIF01000003_gene4649 1.2e-60 240.7 Acidobacteria sorA ko:K07147 ko00000,ko01000 Bacteria 3Y7UP@57723,COG2010@1,COG2010@2,COG2041@1,COG2041@2 NA|NA|NA C Mo-co oxidoreductase dimerisation domain MAG.T1.121_02089 1382356.JQMP01000001_gene959 2.3e-121 442.2 Thermomicrobia nikV 3.6.3.24 ko:K02031,ko:K02032,ko:K10823,ko:K10824 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439,M00440 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 27Z3W@189775,2GARG@200795,COG4608@1,COG4608@2 NA|NA|NA P Oligopeptide/dipeptide transporter, C-terminal region MAG.T1.121_02090 1382356.JQMP01000001_gene960 3.9e-113 414.8 Thermomicrobia oppD ko:K02031,ko:K02032 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 27Z2B@189775,2GBE3@200795,COG0444@1,COG0444@2 NA|NA|NA P Oligopeptide/dipeptide transporter, C-terminal region MAG.T1.121_02091 1382356.JQMP01000001_gene961 7.8e-231 806.6 Thermomicrobia ko:K02035 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 27YY9@189775,2GASZ@200795,COG0747@1,COG0747@2 NA|NA|NA E Bacterial extracellular solute-binding proteins, family 5 Middle MAG.T1.121_02092 309801.trd_1951 2.8e-129 468.4 Thermomicrobia ko:K02033 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 27YWJ@189775,2GAQS@200795,COG0601@1,COG0601@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component MAG.T1.121_02093 1382356.JQMP01000001_gene963 3.2e-94 351.7 Thermomicrobia ko:K02034 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 27YUP@189775,2G8EC@200795,COG1173@1,COG1173@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component MAG.T1.121_02094 927677.ALVU02000004_gene4738 9.2e-77 295.4 Bacteria Bacteria COG3903@1,COG3903@2 NA|NA|NA K ADP binding MAG.T1.121_02096 997346.HMPREF9374_0810 3.7e-54 218.4 Thermoactinomycetaceae Bacteria 1V261@1239,27CTA@186824,4HI81@91061,COG0500@1,COG2226@2 NA|NA|NA Q O-methyltransferase MAG.T1.121_02097 66692.ABC3097 9.9e-18 97.4 Bacillus atl 3.2.1.96,3.4.17.14,3.5.1.28,6.1.1.12 ko:K01227,ko:K01876,ko:K07260,ko:K11060,ko:K13714,ko:K21472 ko00511,ko00550,ko00970,ko01100,ko01502,ko02020,map00511,map00550,map00970,map01100,map01502,map02020 M00359,M00360,M00651 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01002,ko01007,ko01011,ko01504,ko02042,ko03016,ko03029 GH73 Bacteria 1UI28@1239,1ZC2V@1386,4ISBN@91061,COG3103@1,COG3103@2,COG3807@1,COG3807@2,COG4193@1,COG4193@2 NA|NA|NA G Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase MAG.T1.121_02098 66692.ABC3097 6.1e-30 139.4 Bacillus atl 3.2.1.96,3.4.17.14,3.5.1.28,6.1.1.12 ko:K01227,ko:K01876,ko:K07260,ko:K11060,ko:K13714,ko:K21472 ko00511,ko00550,ko00970,ko01100,ko01502,ko02020,map00511,map00550,map00970,map01100,map01502,map02020 M00359,M00360,M00651 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01002,ko01007,ko01011,ko01504,ko02042,ko03016,ko03029 GH73 Bacteria 1UI28@1239,1ZC2V@1386,4ISBN@91061,COG3103@1,COG3103@2,COG3807@1,COG3807@2,COG4193@1,COG4193@2 NA|NA|NA G Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase MAG.T1.121_02100 709986.Deima_2995 2.6e-34 152.5 Deinococcus-Thermus Bacteria 1WJG7@1297,COG1296@1,COG1296@2 NA|NA|NA E Branched-chain amino acid permease MAG.T1.121_02101 1267533.KB906736_gene1029 9.1e-42 177.9 Bacteria pltD 1.14.19.49 ko:K14257 ko00253,ko00404,ko01057,ko01130,map00253,map00404,map01057,map01130 M00790,M00823 R05456,R11106,R11478 RC00949 ko00000,ko00001,ko00002,ko01000 Bacteria COG0654@1,COG0654@2 NA|NA|NA CH COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases MAG.T1.121_02102 479434.Sthe_0701 6.6e-160 570.9 Chloroflexi Bacteria 2G85Y@200795,COG1574@1,COG1574@2 NA|NA|NA S PFAM Amidohydrolase 3 MAG.T1.121_02103 525904.Tter_0602 3.7e-29 135.6 unclassified Bacteria 3.4.16.4,3.5.2.6 ko:K07258,ko:K17836 ko00311,ko00550,ko01100,ko01130,ko01501,map00311,map00550,map01100,map01130,map01501 M00627,M00628 R06363 RC01499 ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504 Bacteria 2NQ4B@2323,COG2367@1,COG2367@2 NA|NA|NA V Beta-lactamase enzyme family MAG.T1.121_02104 1382356.JQMP01000004_gene621 6.1e-48 197.6 Thermomicrobia pcm 2.1.1.77 ko:K00573,ko:K02652 ko00000,ko01000,ko02035,ko02044 3.A.15.2 Bacteria 27Z53@189775,2G6NG@200795,COG2518@1,COG2518@2 NA|NA|NA O Ribosomal RNA adenine dimethylase MAG.T1.121_02105 479434.Sthe_0292 1.5e-28 132.1 Thermomicrobia nuoA 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 27YFR@189775,2G78Y@200795,COG0838@1,COG0838@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient MAG.T1.121_02106 479434.Sthe_0293 2.4e-82 311.6 Thermomicrobia nuoB 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 27XWB@189775,2G6BJ@200795,COG0377@1,COG0377@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient MAG.T1.121_02107 479434.Sthe_0294 4.1e-54 218.0 Thermomicrobia nuoC GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 iAF987.Gmet_3353 Bacteria 27XQI@189775,2G6WD@200795,COG0852@1,COG0852@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient MAG.T1.121_02108 479434.Sthe_0295 4.3e-183 647.5 Thermomicrobia nuoD GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00333,ko:K13378 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 27XG6@189775,2G5MM@200795,COG0649@1,COG0649@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient MAG.T1.121_02109 1382356.JQMP01000003_gene1884 1.9e-120 439.1 Thermomicrobia nuoH 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 iNJ661.Rv3152 Bacteria 27XUJ@189775,2G62Y@200795,COG1005@1,COG1005@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone MAG.T1.121_02110 1382356.JQMP01000003_gene1883 2.9e-43 182.2 Thermomicrobia ndhG 1.6.5.3 ko:K00339,ko:K05578 ko00190,ko01100,map00190,map01100 M00144,M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 27Y64@189775,2G78H@200795,COG0839@1,COG0839@2 NA|NA|NA C Belongs to the complex I subunit 6 family MAG.T1.121_02111 479434.Sthe_0298 6.3e-24 116.7 Thermomicrobia nuoK GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 ko:K00340,ko:K05576 ko00190,ko01100,map00190,map01100 M00144,M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 27YDH@189775,2G782@200795,COG0713@1,COG0713@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient MAG.T1.121_02112 479434.Sthe_0299 1.2e-206 726.5 Thermomicrobia nuoL 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 27XR2@189775,2G5NJ@200795,COG1009@1,COG1009@2 NA|NA|NA C NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus MAG.T1.121_02113 309801.trd_1788 2e-167 595.9 Thermomicrobia nuoM GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 27XEU@189775,2G5VU@200795,COG1008@1,COG1008@2 NA|NA|NA C Proton-conducting membrane transporter MAG.T1.121_02114 479434.Sthe_0301 5.2e-146 524.6 Thermomicrobia nuoN GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 27XVQ@189775,2G5ZK@200795,COG1007@1,COG1007@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient MAG.T1.121_02115 871968.DESME_07305 1.9e-15 89.4 Peptococcaceae Bacteria 1V1G8@1239,24G73@186801,261YS@186807,COG1670@1,COG1670@2 NA|NA|NA J PFAM Acetyltransferase (GNAT) family MAG.T1.121_02116 479434.Sthe_1984 1.1e-33 150.2 Thermomicrobia idi Bacteria 27YIY@189775,2G9TY@200795,COG1443@1,COG1443@2 NA|NA|NA I NUDIX domain MAG.T1.121_02118 525904.Tter_0668 2.7e-54 218.4 unclassified Bacteria catE 1.13.11.2 ko:K07104 ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220 M00569 R00816,R04089,R05295,R05404,R05406,R07795 RC00387,RC00643,RC01075,RC01364,RC01914 ko00000,ko00001,ko00002,ko01000 Bacteria 2NRH9@2323,COG2514@1,COG2514@2 NA|NA|NA S Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily MAG.T1.121_02119 927658.AJUM01000022_gene1065 5.1e-11 74.3 Marinilabiliaceae ko:K07063 ko00000 Bacteria 2FV4N@200643,3XKE4@558415,4NSFI@976,COG1569@1,COG1569@2 NA|NA|NA S PIN domain MAG.T1.121_02122 309801.trd_1343 1.8e-130 472.6 Thermomicrobia Bacteria 27YTW@189775,2GBD0@200795,COG4948@1,COG4948@2 NA|NA|NA M Mandelate racemase / muconate lactonizing enzyme, C-terminal domain MAG.T1.121_02123 1279009.ADICEAN_02287 4.1e-45 188.7 Bacteria Bacteria COG2021@1,COG2021@2 NA|NA|NA E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine MAG.T1.121_02124 479434.Sthe_0485 4.8e-117 429.1 Thermomicrobia ko:K15773 ko00000,ko02048,ko03000 Bacteria 27ZD0@189775,2G7W3@200795,COG0457@1,COG0457@2,COG1396@1,COG1396@2,COG3903@1,COG3903@2 NA|NA|NA K Tetratricopeptide repeat MAG.T1.121_02125 1123237.Salmuc_02187 9.2e-146 523.9 Alphaproteobacteria 1.1.5.9 ko:K19813 ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 R00305 RC00066 ko00000,ko00001,ko01000 Bacteria 1MU3F@1224,2TT3C@28211,COG2303@1,COG2303@2 NA|NA|NA E Oxidoreductase MAG.T1.121_02127 1382356.JQMP01000001_gene961 5.4e-163 581.3 Thermomicrobia ko:K02035 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 27YY9@189775,2GASZ@200795,COG0747@1,COG0747@2 NA|NA|NA E Bacterial extracellular solute-binding proteins, family 5 Middle MAG.T1.121_02128 309801.trd_1951 1e-115 423.3 Thermomicrobia ko:K02033 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 27YWJ@189775,2GAQS@200795,COG0601@1,COG0601@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component MAG.T1.121_02129 1382356.JQMP01000001_gene963 1.3e-64 253.4 Thermomicrobia ko:K02034 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 27YUP@189775,2G8EC@200795,COG1173@1,COG1173@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component MAG.T1.121_02130 1137271.AZUM01000002_gene2268 1.4e-36 159.5 Pseudonocardiales Bacteria 2I2ZW@201174,4E4G5@85010,COG0454@1,COG0454@2 NA|NA|NA K Acetyltransferase (GNAT) family MAG.T1.121_02131 1121924.ATWH01000008_gene773 6.4e-227 793.9 Microbacteriaceae Bacteria 2GKRH@201174,4FN3B@85023,COG0277@1,COG0277@2,COG2141@1,COG2141@2 NA|NA|NA C FAD binding domain MAG.T1.121_02132 1402135.SUH3_08320 2.3e-27 129.0 Sulfitobacter Bacteria 1R62B@1224,2U3MK@28211,3ZZF6@60136,COG2340@1,COG2340@2,COG2931@1,COG2931@2 NA|NA|NA Q Domain of unknown function (DUF4214) MAG.T1.121_02133 479434.Sthe_2141 2.3e-147 529.6 Chloroflexi Bacteria 2GBNC@200795,COG2197@1,COG2197@2,COG3899@1,COG3899@2 NA|NA|NA K AAA ATPase domain MAG.T1.121_02134 136273.GY22_14975 4.3e-13 80.5 Bacteria Bacteria 2DRQB@1,33CKR@2 NA|NA|NA MAG.T1.121_02135 67593.Physo128438 9e-40 171.8 Peronosporales Eukaryota 2S9B6@2759,3QBBA@4776,COG2340@1 NA|NA|NA S Cysteine-rich secretory protein family MAG.T1.121_02136 479434.Sthe_2174 9.1e-30 137.1 Bacteria ko:K03088 ko00000,ko03021 Bacteria COG1595@1,COG1595@2 NA|NA|NA K DNA-templated transcription, initiation MAG.T1.121_02137 479434.Sthe_2173 1.9e-46 193.0 Thermomicrobia cseE 2.1.1.63 ko:K00567 ko00000,ko01000,ko03400 Bacteria 27Z9T@189775,2G98B@200795,COG0350@1,COG0350@2,COG5662@1,COG5662@2 NA|NA|NA L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated MAG.T1.121_02138 1125863.JAFN01000001_gene3139 2.6e-47 196.1 Deltaproteobacteria Bacteria 1PIF4@1224,2WQX1@28221,42UWY@68525,COG0697@1,COG0697@2 NA|NA|NA EG EamA-like transporter family MAG.T1.121_02139 357808.RoseRS_1635 2.1e-88 332.4 Chloroflexia 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 2G5UP@200795,37688@32061,COG2326@1,COG2326@2 NA|NA|NA S Polyphosphate kinase 2 (PPK2) MAG.T1.121_02140 1380394.JADL01000010_gene4339 3.4e-42 178.3 Rhodospirillales flr ko:K09024 ko00240,ko01100,map00240,map01100 R09936 RC02732 ko00000,ko00001,ko01000 Bacteria 1RFJM@1224,2JXDA@204441,2U8B2@28211,COG1853@1,COG1853@2 NA|NA|NA S Flavin reductase like domain MAG.T1.121_02141 1123023.JIAI01000002_gene5635 1.1e-225 789.3 Pseudonocardiales 1.14.14.9 ko:K00483 ko00350,ko01120,ko01220,map00350,map01120,map01220 R02698,R03299 RC00046 ko00000,ko00001,ko01000 Bacteria 2GKIQ@201174,4DYKH@85010,COG2368@1,COG2368@2 NA|NA|NA Q PFAM 4-hydroxyphenylacetate 3-hydroxylase MAG.T1.121_02142 246196.MSMEI_1640 1.5e-55 222.2 Mycobacteriaceae Bacteria 2344B@1762,2HN9X@201174,COG0251@1,COG0251@2 NA|NA|NA J Endoribonuclease L-PSP MAG.T1.121_02143 1463854.JOHT01000002_gene2430 7.9e-67 260.4 Actinobacteria fimA Bacteria 2HWBG@201174,COG3342@1,COG3342@2 NA|NA|NA S Family of unknown function (DUF1028) MAG.T1.121_02144 570268.ANBB01000044_gene1825 3.6e-63 250.0 Streptosporangiales ko:K06889 ko00000 Bacteria 2GKYQ@201174,4EQGH@85012,COG1073@1,COG1073@2 NA|NA|NA S Hydrolases of the alpha beta superfamily MAG.T1.121_02146 309801.trd_1853 2.5e-113 415.6 Thermomicrobia ko:K09703 ko00000 Bacteria 27Z08@189775,2GA3G@200795,COG3535@1,COG3535@2 NA|NA|NA S Protein of unknown function (DUF917) MAG.T1.121_02147 479434.Sthe_1406 7.7e-35 153.7 Thermomicrobia Bacteria 27YGM@189775,2G77J@200795,COG1051@1,COG1051@2 NA|NA|NA F NUDIX domain MAG.T1.121_02148 1382356.JQMP01000004_gene226 1.6e-31 142.5 Thermomicrobia ko:K09386 ko00000 Bacteria 27YFP@189775,2G6U6@200795,COG3427@1,COG3427@2 NA|NA|NA S Polyketide cyclase / dehydrase and lipid transport MAG.T1.121_02149 1267535.KB906767_gene990 4.7e-45 187.2 Acidobacteriia mhqA 3.4.21.26 ko:K01322,ko:K15975 ko04614,map04614 ko00000,ko00001,ko01000,ko01002 Bacteria 2JKDJ@204432,3Y61Q@57723,COG0346@1,COG0346@2 NA|NA|NA E PFAM Glyoxalase bleomycin resistance protein dioxygenase MAG.T1.121_02150 395961.Cyan7425_5147 2e-74 286.6 Bacteria Bacteria COG1409@1,COG1409@2 NA|NA|NA S acid phosphatase activity MAG.T1.121_02151 1394178.AWOO02000001_gene1331 8.7e-57 227.6 Actinobacteria Bacteria 2IMUZ@201174,COG0673@1,COG0673@2 NA|NA|NA S Oxidoreductase family, NAD-binding Rossmann fold MAG.T1.121_02152 1125699.HMPREF9194_02245 9.4e-15 86.3 Spirochaetes rhaU 5.1.3.32 ko:K03534 R10819 RC00563 ko00000,ko01000 Bacteria 2J95S@203691,COG3254@1,COG3254@2 NA|NA|NA G Involved in the anomeric conversion of L-rhamnose MAG.T1.121_02153 337075.U4LA97 1.3e-120 439.9 Ascomycota 4.2.1.90 ko:K12661 ko00051,ko01120,map00051,map01120 R03774 RC00543 ko00000,ko00001,ko01000 Fungi 39QNW@33154,3Q6RI@4751,3RPK4@4890,COG1028@1,KOG1200@2759 NA|NA|NA Q Mandelate racemase / muconate lactonizing enzyme, C-terminal domain MAG.T1.121_02154 1123501.KB902276_gene1138 1.9e-27 128.3 Alphaproteobacteria MA20_01405 Bacteria 1MZBV@1224,2UC5C@28211,COG5552@1,COG5552@2 NA|NA|NA S Uncharacterized conserved protein (DUF2277) MAG.T1.121_02155 1395571.TMS3_0108740 8.1e-142 510.4 Gammaproteobacteria ko:K03088 ko00000,ko03021 Bacteria 1MU3D@1224,1RN25@1236,COG4941@1,COG4941@2 NA|NA|NA K Belongs to the sigma-70 factor family MAG.T1.121_02156 926550.CLDAP_33430 3.5e-173 614.4 Chloroflexi Bacteria 2G5ZD@200795,COG4447@1,COG4447@2 NA|NA|NA S BNR/Asp-box repeat MAG.T1.121_02157 926550.CLDAP_33420 8e-32 142.9 Chloroflexi 2.7.7.80,2.8.1.11 ko:K03636,ko:K21147 ko04122,map04122 R07459,R07461 RC00043 ko00000,ko00001,ko01000 Bacteria 2G6VH@200795,COG1977@1,COG1977@2 NA|NA|NA H Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin MAG.T1.121_02158 479434.Sthe_2960 7.3e-40 169.9 Chloroflexi Bacteria 2G9DM@200795,COG3795@1,COG3795@2 NA|NA|NA S YCII-related domain MAG.T1.121_02159 661478.OP10G_4543 9.3e-27 126.3 Bacteria Bacteria COG3795@1,COG3795@2 NA|NA|NA F YCII-related domain MAG.T1.121_02160 1246445.ANAY01000016_gene2255 2.1e-37 162.2 Streptosporangiales Bacteria 2ISVS@201174,4EK0A@85012,COG3832@1,COG3832@2 NA|NA|NA S Activator of Hsp90 ATPase homolog 1-like protein MAG.T1.121_02161 1116369.KB890024_gene769 4.4e-35 154.1 Phyllobacteriaceae Bacteria 1RH5P@1224,2U960@28211,43KDS@69277,COG0640@1,COG0640@2 NA|NA|NA K helix_turn_helix, Arsenical Resistance Operon Repressor MAG.T1.121_02162 1123242.JH636434_gene3236 1.1e-137 496.9 Planctomycetes Bacteria 2J2WQ@203682,COG5476@1,COG5476@2 NA|NA|NA S MlrC C-terminus MAG.T1.121_02163 82995.CR62_22375 1.5e-56 226.5 Serratia str 2.7.1.72 ko:K04343 M00766 R02225 RC00002,RC00078 br01600,ko00000,ko00002,ko01000,ko01504 Bacteria 1MW4R@1224,1S2D2@1236,401NM@613,COG3570@1,COG3570@2 NA|NA|NA G Aminoglycoside/hydroxyurea antibiotic resistance kinase MAG.T1.121_02164 1122223.KB890688_gene1616 2.2e-71 276.6 Deinococcus-Thermus ko:K02027 M00207 ko00000,ko00002,ko02000 3.A.1.1 Bacteria 1WJIN@1297,COG1653@1,COG1653@2 NA|NA|NA G Bacterial extracellular solute-binding protein MAG.T1.121_02165 357808.RoseRS_3149 7.1e-91 341.3 Chloroflexia ko:K02027 M00207 ko00000,ko00002,ko02000 3.A.1.1 Bacteria 2G82H@200795,377G1@32061,COG1653@1,COG1653@2 NA|NA|NA G PFAM extracellular solute-binding protein family 1 MAG.T1.121_02166 357808.RoseRS_3150 1.3e-60 240.0 Chloroflexi ko:K02026 M00207 ko00000,ko00002,ko02000 3.A.1.1 Bacteria 2G8GJ@200795,COG0395@1,COG0395@2 NA|NA|NA U Binding-protein-dependent transport system inner membrane component MAG.T1.121_02167 1313172.YM304_07600 4.5e-16 90.5 Actinobacteria ko:K02025,ko:K05814,ko:K10118,ko:K10228,ko:K10233,ko:K15771 ko02010,map02010 M00196,M00198,M00200,M00201,M00207,M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.2,3.A.1.1.28,3.A.1.1.3,3.A.1.1.32,3.A.1.1.5,3.A.1.1.8 Bacteria 2GKBJ@201174,COG1175@1,COG1175@2 NA|NA|NA G PFAM binding-protein-dependent transport systems inner membrane component MAG.T1.121_02168 886293.Sinac_0810 7.6e-39 167.5 Planctomycetes estA ko:K03930,ko:K17076 ko02010,map02010 M00589 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3.20 CE1 Bacteria 2J56U@203682,COG0627@1,COG0627@2 NA|NA|NA S Putative esterase MAG.T1.121_02169 1382356.JQMP01000003_gene1940 5.8e-48 199.5 Thermomicrobia ko:K03642,ko:K19223 ko00000,ko01000,ko01002,ko01011 CBM50 Bacteria 27XPH@189775,2G99E@200795,COG0791@1,COG0791@2,COG3103@1,COG4991@2 NA|NA|NA MT NlpC/P60 family MAG.T1.121_02170 1380347.JNII01000009_gene2045 1.3e-50 207.2 Frankiales ko:K19200 ko00311,ko01100,ko01130,map00311,map01100,map01130 ko00000,ko00001,ko01002 Bacteria 2HU27@201174,4EWJV@85013,COG4927@1,COG4927@2 NA|NA|NA S Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase MAG.T1.121_02171 1120950.KB892741_gene2629 2.8e-128 464.9 Propionibacteriales gnl 3.1.1.17 ko:K01053 ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220 M00129 R01519,R02933,R03751 RC00537,RC00983 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GIW1@201174,4DPX6@85009,COG3386@1,COG3386@2 NA|NA|NA G SMP-30/Gluconolaconase/LRE-like region MAG.T1.121_02172 479432.Sros_7688 3.5e-45 189.5 Actinobacteria Bacteria 2GNRZ@201174,COG2367@1,COG2367@2 NA|NA|NA V Beta-lactamase class A MAG.T1.121_02173 926554.KI912664_gene1577 4.4e-14 87.8 Deinococcus-Thermus Bacteria 1WNBY@1297,29XYR@1,30JRD@2 NA|NA|NA S Lysyl oxidase MAG.T1.121_02174 525904.Tter_2361 2.4e-59 235.7 unclassified Bacteria Bacteria 2NRAR@2323,COG1028@1,COG1028@2 NA|NA|NA IQ Enoyl-(Acyl carrier protein) reductase MAG.T1.121_02175 869210.Marky_1921 2.8e-19 101.7 Deinococcus-Thermus Bacteria 1WK3F@1297,COG0517@1,COG0517@2,COG5485@1,COG5485@2 NA|NA|NA S Domain in cystathionine beta-synthase and other proteins. MAG.T1.121_02176 471854.Dfer_3133 1.5e-40 172.9 Cytophagia cobC 3.1.3.3,3.1.3.73,5.4.2.12 ko:K02226,ko:K15634,ko:K15640,ko:K22305 ko00010,ko00260,ko00680,ko00860,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00122 R00582,R01518,R04594,R11173 RC00017,RC00536 ko00000,ko00001,ko00002,ko01000 Bacteria 47Q0B@768503,4NNN0@976,COG0406@1,COG0406@2 NA|NA|NA G Phosphoglycerate mutase family MAG.T1.121_02177 309801.trd_1281 1.5e-103 383.6 Thermomicrobia ko:K02035 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 27YT9@189775,2GA2M@200795,COG0747@1,COG0747@2 NA|NA|NA E Bacterial extracellular solute-binding proteins, family 5 Middle MAG.T1.121_02178 530564.Psta_1277 3.1e-92 344.7 Planctomycetes nrdB 1.17.4.1 ko:K00526 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 iJN746.PP_1177 Bacteria 2IXNY@203682,COG0208@1,COG0208@2 NA|NA|NA F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides MAG.T1.121_02179 525904.Tter_1188 3.9e-227 794.7 unclassified Bacteria metE GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003871,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0030312,GO:0032259,GO:0040007,GO:0042084,GO:0042085,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050667,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.14 ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R04405,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 Bacteria 2NPAE@2323,COG0620@1,COG0620@2 NA|NA|NA E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation MAG.T1.121_02180 316274.Haur_4158 3.9e-39 169.5 Bacteria ko:K08970 ko00000,ko02000 2.A.52.2 Bacteria COG2215@1,COG2215@2 NA|NA|NA O Belongs to the NiCoT transporter (TC 2.A.52) family MAG.T1.121_02181 251221.35211940 2.6e-77 297.0 Cyanobacteria Bacteria 1G5W7@1117,COG3629@1,COG3629@2,COG3903@1,COG3903@2 NA|NA|NA K Bacterial transcriptional activator domain MAG.T1.121_02182 1415166.NONO_c44230 3.4e-77 296.6 Nocardiaceae Bacteria 2GIZ1@201174,4FUTU@85025,COG0515@1,COG0515@2,COG3903@1,COG3903@2 NA|NA|NA K activity, protein serine threonine kinase activity, protein-tyrosine kinase activity, ATP binding, regulation of transcription, DNA-dependent, protein amino acid phosphorylation MAG.T1.121_02183 479434.Sthe_2629 1.1e-44 186.8 Thermomicrobia terC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 27Z5P@189775,2G7D5@200795,COG0861@1,COG0861@2 NA|NA|NA P Integral membrane protein TerC family MAG.T1.121_02184 1128421.JAGA01000001_gene2279 1.9e-72 279.6 unclassified Bacteria ctaB GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 Bacteria 2NPBW@2323,COG0109@1,COG0109@2 NA|NA|NA O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group MAG.T1.121_02185 479434.Sthe_1814 1.3e-120 440.3 Thermomicrobia wapA ko:K07152,ko:K13730 ko05100,map05100 ko00000,ko00001,ko03029 Bacteria 27XX5@189775,2GAQJ@200795,COG1999@1,COG1999@2,COG3391@1,COG3391@2 NA|NA|NA S amine dehydrogenase activity MAG.T1.121_02187 1236902.ANAS01000022_gene142 2.8e-18 98.6 Actinobacteria Bacteria 2H9ZU@201174,COG0346@1,COG0346@2 NA|NA|NA E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily MAG.T1.121_02188 1121346.KB899837_gene1240 1.6e-43 183.0 Paenibacillaceae Bacteria 1TZ1N@1239,26RS2@186822,4HEBF@91061,COG2761@1,COG2761@2 NA|NA|NA Q DSBA oxidoreductase MAG.T1.121_02189 566461.SSFG_03888 4.1e-22 111.3 Actinobacteria Bacteria 2I4MJ@201174,COG3153@1,COG3153@2 NA|NA|NA S Acetyltransferase (GNAT) domain MAG.T1.121_02190 31964.CMS2192 1.3e-118 433.0 Microbacteriaceae ko:K07497 ko00000 Bacteria 2GJ3V@201174,4FNHF@85023,COG2801@1,COG2801@2 NA|NA|NA L insertion element ISCmi2 transposase MAG.T1.121_02191 331869.BAL199_02434 3.1e-151 542.0 unclassified Alphaproteobacteria 1.1.3.47,1.1.99.1 ko:K00108,ko:K16873 ko00260,ko00365,ko01100,ko01120,map00260,map00365,map01100,map01120 M00555 R01025,R10212,R10216,R10858 RC00075,RC00087,RC03291 ko00000,ko00001,ko00002,ko01000 Bacteria 1N0NP@1224,2TQSK@28211,4BRQ5@82117,COG2303@1,COG2303@2 NA|NA|NA E GMC oxidoreductase MAG.T1.121_02192 1365176.N186_07020 8.1e-98 364.0 Crenarchaeota ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 ko00000,ko00001,ko00002,ko02000 3.A.1.1 Archaea 2XPUC@28889,COG3839@1,arCOG00175@2157 NA|NA|NA G PFAM ABC transporter related MAG.T1.121_02193 1120950.KB892792_gene2395 2e-53 216.5 Propionibacteriales ko:K18106 ko00040,ko01100,map00040,map01100 M00630 R07676,R10565 RC00108 ko00000,ko00001,ko00002,ko01000 Bacteria 2IEY3@201174,4DTAE@85009,COG0673@1,COG0673@2 NA|NA|NA S Oxidoreductase family, NAD-binding Rossmann fold MAG.T1.121_02194 1089551.KE386572_gene1570 5.2e-156 558.1 Alphaproteobacteria ko:K02025,ko:K02026,ko:K15771 ko02010,map02010 M00207,M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.2 Bacteria 1RGER@1224,2VFRY@28211,COG0395@1,COG0395@2,COG1175@1,COG1175@2 NA|NA|NA G Binding-protein-dependent transport system inner membrane component MAG.T1.121_02195 1089551.KE386572_gene1571 1.1e-115 423.7 Alphaproteobacteria ko:K02027 M00207 ko00000,ko00002,ko02000 3.A.1.1 Bacteria 1N4MG@1224,2UEYN@28211,COG1653@1,COG1653@2 NA|NA|NA G Bacterial extracellular solute-binding protein MAG.T1.121_02197 552811.Dehly_1197 5.6e-95 354.8 Dehalococcoidia ko:K13963 ko05146,map05146 ko00000,ko00001 Bacteria 2GBWN@200795,34D50@301297,COG4826@1,COG4826@2 NA|NA|NA M SERine Proteinase INhibitors MAG.T1.121_02198 1206720.BAFQ01000190_gene4927 8.6e-39 166.4 Nocardiaceae Bacteria 2IKP7@201174,4G17K@85025,COG0346@1,COG0346@2 NA|NA|NA E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily MAG.T1.121_02201 497964.CfE428DRAFT_0631 8.9e-123 448.4 Verrucomicrobia Bacteria 46TZ3@74201,COG2114@1,COG2114@2,COG3903@1,COG3903@2 NA|NA|NA T Adenylyl- / guanylyl cyclase, catalytic domain MAG.T1.121_02202 266117.Rxyl_2601 2.5e-88 332.0 Rubrobacteria 3.6.3.17 ko:K01996,ko:K02056 ko02010,ko02024,map02010,map02024 M00221,M00237 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2,3.A.1.4 Bacteria 2GJDV@201174,4CRFV@84995,COG1129@1,COG1129@2 NA|NA|NA G ATPases associated with a variety of cellular activities MAG.T1.121_02203 485913.Krac_8942 3.8e-69 268.5 Chloroflexi Bacteria 2G8CA@200795,COG2141@1,COG2141@2 NA|NA|NA C Luciferase-like monooxygenase MAG.T1.121_02204 990285.RGCCGE502_14780 1.9e-179 635.6 Rhizobiaceae 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 Bacteria 1MUJH@1224,2TSB8@28211,4B9EB@82115,COG3119@1,COG3119@2 NA|NA|NA P Arylsulfatase MAG.T1.121_02206 1206741.BAFX01000206_gene344 1.4e-10 75.1 Nocardiaceae 3.6.1.27 ko:K19302 ko00550,map00550 R05627 RC00002 ko00000,ko00001,ko01000,ko01011 Bacteria 2I9FB@201174,4G24K@85025,COG0671@1,COG0671@2 NA|NA|NA I Acid phosphatase homologues MAG.T1.121_02207 1896.JOAU01000007_gene5842 1.8e-56 226.9 Actinobacteria Bacteria 2GMKX@201174,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily MAG.T1.121_02208 1157490.EL26_14475 5.6e-29 135.6 Firmicutes ko:K07785 ko02020,map02020 ko00000,ko00001,ko02000 2.A.1.31 Bacteria 1UI7B@1239,COG0477@1,COG0477@2 NA|NA|NA EGP Major facilitator superfamily MAG.T1.121_02209 479434.Sthe_2633 2.1e-12 79.0 Thermomicrobia Bacteria 27YMR@189775,2A4RE@1,2GBB8@200795,30TCT@2 NA|NA|NA MAG.T1.121_02210 246194.CHY_0109 7.5e-13 80.9 Clostridia Bacteria 1VQH0@1239,24X4Z@186801,COG3339@1,COG3339@2 NA|NA|NA S Protein of unknown function (DUF1232) MAG.T1.121_02211 469383.Cwoe_2964 3.1e-122 446.0 Rubrobacteria Bacteria 2HH0Q@201174,4CRNQ@84995,COG1524@1,COG1524@2 NA|NA|NA S Mycobacterial 4 TMS phage holin, superfamily IV MAG.T1.121_02212 1128421.JAGA01000002_gene1835 4e-56 224.9 unclassified Bacteria Bacteria 2NPHT@2323,COG0639@1,COG0639@2 NA|NA|NA T Calcineurin-like phosphoesterase superfamily domain MAG.T1.121_02213 1122609.AUGT01000021_gene1304 4e-13 82.8 Bacteria Bacteria COG0477@1,COG0477@2 NA|NA|NA EGP Major facilitator Superfamily MAG.T1.121_02214 1455608.JDTH01000006_gene2664 4.4e-10 72.8 Halobacteria ko:K17713 ko00000,ko02000 1.B.33.1 Archaea 23SYZ@183963,2Y7Q0@28890,COG1520@1,arCOG02492@2157 NA|NA|NA M COG1520 FOG WD40-like repeat MAG.T1.121_02216 1382356.JQMP01000004_gene274 4.4e-120 438.7 Thermomicrobia appA ko:K02035 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 27Y2G@189775,2G5SA@200795,COG0747@1,COG0747@2 NA|NA|NA E PFAM extracellular solute-binding protein family 5 MAG.T1.121_02217 1144275.COCOR_04366 4.5e-132 478.8 Deltaproteobacteria ko:K14645 ko02024,map02024 ko00000,ko00001,ko01000,ko01002,ko03110 Bacteria 1QUY9@1224,2X7UT@28221,43CKC@68525,COG3291@1,COG3291@2,COG4870@1,COG4870@2 NA|NA|NA O Pkd domain containing protein MAG.T1.121_02218 1122138.AQUZ01000087_gene1186 3.4e-104 385.6 Propionibacteriales Bacteria 2GIT0@201174,4DQCH@85009,COG2234@1,COG2234@2 NA|NA|NA S Peptidase family M28 MAG.T1.121_02219 1173024.KI912151_gene2020 1.8e-13 82.0 Bacteria Bacteria 2E8HZ@1,332W1@2 NA|NA|NA MAG.T1.121_02220 926550.CLDAP_33340 5e-16 91.3 Chloroflexi Bacteria 2G7DA@200795,COG5485@1,COG5485@2 NA|NA|NA P SnoaL-like polyketide cyclase MAG.T1.121_02221 383372.Rcas_3070 2.7e-28 132.9 Chloroflexia corA ko:K03284 ko00000,ko02000 1.A.35.1,1.A.35.3 Bacteria 2G6EQ@200795,375MB@32061,COG0598@1,COG0598@2 NA|NA|NA P Mediates influx of magnesium ions MAG.T1.121_02222 768671.ThimaDRAFT_2107 1.4e-35 156.0 Proteobacteria Bacteria 1R3IR@1224,2E61I@1,2ZBKY@2 NA|NA|NA MAG.T1.121_02223 1341181.FLJC2902T_23310 1.6e-55 223.0 Flavobacterium Bacteria 1IADF@117743,2C3WA@1,2NX79@237,2Z8P1@2,4NW8R@976 NA|NA|NA MAG.T1.121_02224 1297570.MESS4_670033 0.0 1162.9 Phyllobacteriaceae atsD GO:0000323,GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0004065,GO:0004098,GO:0005488,GO:0005509,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005764,GO:0005766,GO:0005773,GO:0005775,GO:0005783,GO:0005788,GO:0006629,GO:0006643,GO:0006664,GO:0006665,GO:0006687,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0008150,GO:0008152,GO:0008484,GO:0009987,GO:0012505,GO:0016192,GO:0016787,GO:0016788,GO:0030141,GO:0031410,GO:0031974,GO:0031982,GO:0031983,GO:0032940,GO:0034774,GO:0035578,GO:0036230,GO:0042119,GO:0042582,GO:0043167,GO:0043169,GO:0043202,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043299,GO:0043312,GO:0044237,GO:0044238,GO:0044255,GO:0044422,GO:0044424,GO:0044432,GO:0044433,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0046872,GO:0046903,GO:0050896,GO:0051179,GO:0051234,GO:0060205,GO:0070013,GO:0071704,GO:0097708,GO:0099503,GO:1901135,GO:1901564,GO:1903509 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 Bacteria 1MV92@1224,2TTXG@28211,43K0Q@69277,COG3119@1,COG3119@2 NA|NA|NA P Sulfatase MAG.T1.121_02225 266117.Rxyl_2603 8e-80 303.9 Rubrobacteria rbsB ko:K10439 ko02010,ko02030,map02010,map02030 M00212 ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 Bacteria 2GNSX@201174,4CS59@84995,COG1879@1,COG1879@2 NA|NA|NA G Periplasmic binding proteins and sugar binding domain of LacI family MAG.T1.121_02226 1267535.KB906767_gene4273 1.7e-67 262.7 Acidobacteria Bacteria 3Y7U3@57723,COG1028@1,COG1028@2 NA|NA|NA IQ KR domain MAG.T1.121_02227 469383.Cwoe_4313 1.6e-39 169.9 Bacteria Bacteria COG2220@1,COG2220@2 NA|NA|NA S N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity MAG.T1.121_02229 525904.Tter_2518 2.5e-97 362.5 unclassified Bacteria Bacteria 2NR3V@2323,COG4948@1,COG4948@2 NA|NA|NA M Mandelate racemase / muconate lactonizing enzyme, N-terminal domain MAG.T1.121_02230 1487953.JMKF01000037_gene3241 1.2e-52 214.2 Oscillatoriales 3.4.16.4 ko:K01286 ko00000,ko01000 Bacteria 1G5C3@1117,1HAVU@1150,COG1680@1,COG1680@2,COG2931@1,COG2931@2 NA|NA|NA Q Haemolysin-type calcium-binding repeat (2 copies) MAG.T1.121_02231 1382356.JQMP01000001_gene1112 6.3e-11 75.1 Thermomicrobia Bacteria 27Z6N@189775,2GBEQ@200795,COG4454@1,COG4454@2 NA|NA|NA MAG.T1.121_02232 485913.Krac_2143 1.3e-13 83.2 Chloroflexi Bacteria 2G7DA@200795,COG5485@1,COG5485@2 NA|NA|NA P SnoaL-like polyketide cyclase MAG.T1.121_02233 37919.EP51_27600 1.5e-88 334.3 Nocardiaceae Bacteria 2GIZ1@201174,4FUTU@85025,COG2197@1,COG2197@2,COG3903@1,COG3903@2 NA|NA|NA K activity, protein serine threonine kinase activity, protein-tyrosine kinase activity, ATP binding, regulation of transcription, DNA-dependent, protein amino acid phosphorylation MAG.T1.121_02234 565653.EGBG_02856 1.6e-10 75.5 Enterococcaceae lytG ko:K02395,ko:K14196,ko:K19220 ko05150,map05150 ko00000,ko00001,ko01000,ko01002,ko01011,ko02035 Bacteria 1UYRM@1239,4AZE2@81852,4HAU6@91061,COG1388@1,COG1388@2,COG1705@1,COG1705@2,COG3103@1,COG4991@2 NA|NA|NA MNU defense response to other organism MAG.T1.121_02237 309801.trd_A0447 8.4e-45 186.4 Thermomicrobia 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 27Y13@189775,2G5K7@200795,COG0304@1,COG0304@2 NA|NA|NA I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP MAG.T1.121_02238 479434.Sthe_2659 3.5e-61 241.5 Thermomicrobia soj GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009295,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044464,GO:0071944 ko:K03496 ko00000,ko03036,ko04812 Bacteria 27XPM@189775,2G62U@200795,COG1192@1,COG1192@2 NA|NA|NA D Anion-transporting ATPase MAG.T1.121_02239 479434.Sthe_2660 4.9e-84 318.2 Thermomicrobia ko:K03497 ko00000,ko03000,ko03036,ko04812 Bacteria 27XRN@189775,2G6EK@200795,COG1475@1,COG1475@2 NA|NA|NA K ParB-like nuclease domain MAG.T1.121_02241 479434.Sthe_2247 1e-138 501.1 Chloroflexi Bacteria 2G80F@200795,COG2909@1,COG2909@2 NA|NA|NA K helix_turn_helix, Lux Regulon MAG.T1.121_02242 296591.Bpro_3192 5.4e-27 126.7 Comamonadaceae Bacteria 1N2FZ@1224,2AGAH@1,2WDAY@28216,316G1@2,4AIKB@80864 NA|NA|NA S Protein of unknown function (DUF4242) MAG.T1.121_02243 469383.Cwoe_2685 7.4e-09 67.4 Actinobacteria Bacteria 2H15W@201174,COG1917@1,COG1917@2 NA|NA|NA S Cupin 2, conserved barrel domain protein MAG.T1.121_02244 1123508.JH636439_gene1068 8.8e-78 297.4 Planctomycetes fieF Bacteria 2IY05@203682,COG0053@1,COG0053@2 NA|NA|NA P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family MAG.T1.121_02246 1353528.DT23_10625 1e-35 157.5 Proteobacteria 3.4.11.5 ko:K01259,ko:K06889 ko00330,map00330 R00135 ko00000,ko00001,ko01000,ko01002 Bacteria 1NFKR@1224,COG1073@1,COG1073@2 NA|NA|NA S alpha beta MAG.T1.121_02247 1353528.DT23_10625 1.4e-33 150.6 Proteobacteria 3.4.11.5 ko:K01259,ko:K06889 ko00330,map00330 R00135 ko00000,ko00001,ko01000,ko01002 Bacteria 1NFKR@1224,COG1073@1,COG1073@2 NA|NA|NA S alpha beta MAG.T1.121_02248 1353528.DT23_10625 1.6e-36 160.2 Proteobacteria 3.4.11.5 ko:K01259,ko:K06889 ko00330,map00330 R00135 ko00000,ko00001,ko01000,ko01002 Bacteria 1NFKR@1224,COG1073@1,COG1073@2 NA|NA|NA S alpha beta MAG.T1.121_02249 1300350.DSW25_05145 1.1e-105 390.2 Sulfitobacter Bacteria 1MW3G@1224,2TRR6@28211,3ZWZ4@60136,COG0455@1,COG0455@2 NA|NA|NA D GSCFA family MAG.T1.121_02254 1384057.CD33_07660 9.4e-73 280.8 Lysinibacillus Bacteria 1TQMS@1239,3IWB5@400634,4HCY5@91061,COG4948@1,COG4948@2 NA|NA|NA M Belongs to the mandelate racemase muconate lactonizing enzyme family MAG.T1.121_02255 670487.Ocepr_1699 3.6e-10 71.6 Deinococcus-Thermus 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 Bacteria 1WI6K@1297,COG3375@1,COG3375@2 NA|NA|NA M carboxylic acid catabolic process MAG.T1.121_02256 1511.CLOST_0582 5.2e-72 278.1 Peptostreptococcaceae oppC ko:K02034,ko:K15582 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 1TP4R@1239,2489T@186801,25SV4@186804,COG1173@1,COG1173@2 NA|NA|NA EP N-terminal TM domain of oligopeptide transport permease C MAG.T1.121_02257 999141.GME_14355 1.8e-74 286.2 Oceanospirillales oppB GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 ko:K02033,ko:K15581 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 1MU8Z@1224,1RNJ1@1236,1XJ29@135619,COG0601@1,COG0601@2 NA|NA|NA P transporter, permease MAG.T1.121_02258 1408438.JADD01000024_gene1281 7.4e-61 242.3 Aerococcaceae oppA ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 1TNYQ@1239,27DNE@186827,4HAMK@91061,COG4166@1,COG4166@2 NA|NA|NA E Bacterial extracellular solute-binding proteins, family 5 Middle MAG.T1.121_02259 1157943.KB892705_gene2336 3e-89 336.7 Mycobacteriaceae 2.7.11.1 ko:K08282 ko00000,ko01000 Bacteria 233DM@1762,2GIZ1@201174,COG0515@1,COG0515@2,COG3903@1,COG3903@2 NA|NA|NA K involved in signal transduction (via phosphorylation) involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites catalytic activity ATP a protein ADP a phosphoprotein MAG.T1.121_02260 1122132.AQYH01000017_gene1016 9.1e-67 260.4 Rhizobiaceae Bacteria 1MURZ@1224,2UQH0@28211,4BDK8@82115,COG1028@1,COG1028@2 NA|NA|NA IQ Enoyl-(Acyl carrier protein) reductase MAG.T1.121_02261 107635.AZUO01000001_gene1410 1.6e-21 109.4 Methylocystaceae sixA ko:K08296 ko00000,ko01000 Bacteria 1N0FX@1224,2UBYD@28211,36YMG@31993,COG2062@1,COG2062@2 NA|NA|NA T Phosphoglycerate mutase family MAG.T1.121_02262 1089551.KE386572_gene3026 8.1e-191 674.1 unclassified Alphaproteobacteria 1.5.3.1,2.1.2.10 ko:K00303,ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R00610,R01221,R02300,R04125 RC00022,RC00060,RC00069,RC00183,RC00557,RC02834 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUXJ@1224,2TRGS@28211,4BRV2@82117,COG0404@1,COG0404@2,COG0665@1,COG0665@2 NA|NA|NA E FAD dependent oxidoreductase central domain MAG.T1.121_02264 196162.Noca_4966 4.5e-138 498.8 Actinobacteria ko:K06994,ko:K07003 ko00000 Bacteria 2GJ5A@201174,COG2409@1,COG2409@2 NA|NA|NA F Drug exporters of the RND superfamily MAG.T1.121_02265 1121090.KB894688_gene1657 3.9e-83 315.1 Bacillus pstC ko:K02037,ko:K02038 ko02010,map02010 M00222 ko00000,ko00001,ko00002,ko02000 3.A.1.7 Bacteria 1TSPP@1239,1ZAUU@1386,4HC9H@91061,COG0573@1,COG0573@2 NA|NA|NA P probably responsible for the translocation of the substrate across the membrane MAG.T1.121_02266 1123234.AUKI01000024_gene2112 3.9e-86 325.1 Flavobacteriia pstS GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015698,GO:0016020,GO:0042301,GO:0043167,GO:0043168,GO:0044464,GO:0051179,GO:0051234,GO:0071944 ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 ko00000,ko00001,ko00002,ko02000 3.A.1.7 Bacteria 1IIZQ@117743,4NH1G@976,COG0226@1,COG0226@2 NA|NA|NA P PBP superfamily domain MAG.T1.121_02267 429009.Adeg_1028 1.4e-48 199.9 Thermoanaerobacterales Bacteria 1TPZ0@1239,249IC@186801,42G27@68295,COG0745@1,COG0745@2 NA|NA|NA K response regulator MAG.T1.121_02268 525904.Tter_1268 1.2e-73 283.9 unclassified Bacteria prc 3.4.21.102 ko:K03797 ko00000,ko01000,ko01002 Bacteria 2NNVZ@2323,COG0793@1,COG0793@2 NA|NA|NA M Belongs to the peptidase S41A family MAG.T1.121_02269 1382356.JQMP01000003_gene2431 1.1e-48 200.3 Thermomicrobia coaX 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1986 Bacteria 27Y5M@189775,2G6B4@200795,COG1521@1,COG1521@2 NA|NA|NA F Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis MAG.T1.121_02270 479434.Sthe_0459 2e-238 832.0 Thermomicrobia fusA2 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0030312,GO:0044237,GO:0044464,GO:0071944 ko:K02355 ko00000,ko03012,ko03029 Bacteria 27XJI@189775,2G680@200795,COG0480@1,COG0480@2 NA|NA|NA J Elongation factor G, domain IV MAG.T1.121_02271 479434.Sthe_0458 1.4e-19 102.8 Thermomicrobia rnhA GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006401,GO:0006725,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016891,GO:0016893,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0032296,GO:0033013,GO:0033014,GO:0034641,GO:0034655,GO:0042364,GO:0042578,GO:0043170,GO:0043755,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046700,GO:0051186,GO:0051188,GO:0071667,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576 3.1.26.4,3.1.3.73 ko:K03469,ko:K06864,ko:K22316 ko00860,ko01100,ko03030,map00860,map01100,map03030 M00122 R04594 RC00017 ko00000,ko00001,ko00002,ko01000,ko03032 Bacteria 27YNH@189775,2GB0N@200795,COG0328@1,COG0328@2 NA|NA|NA L Reverse transcriptase-like MAG.T1.121_02273 479434.Sthe_0439 4.8e-54 218.8 Thermomicrobia dacA 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 ko00000,ko00001,ko01000,ko01002,ko01011 Bacteria 27XVX@189775,2G8TU@200795,COG1686@1,COG1686@2 NA|NA|NA M Belongs to the peptidase S11 family MAG.T1.121_02274 479434.Sthe_0456 4.2e-240 837.4 Thermomicrobia thrS GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 27XPW@189775,2G5PZ@200795,COG0441@1,COG0441@2 NA|NA|NA J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) MAG.T1.121_02275 1382356.JQMP01000003_gene2201 2.1e-51 208.8 Thermomicrobia 3.5.1.124 ko:K05520 ko00000,ko01000,ko01002 Bacteria 27Y86@189775,2G8WZ@200795,COG0693@1,COG0693@2 NA|NA|NA S DJ-1/PfpI family MAG.T1.121_02276 309801.trd_1070 6e-59 234.6 Thermomicrobia 3.1.3.41 ko:K01101 ko00627,ko01120,map00627,map01120 R03024 RC00151 ko00000,ko00001,ko01000 Bacteria 27XZJ@189775,2G6G5@200795,COG0647@1,COG0647@2 NA|NA|NA G PFAM Haloacid dehalogenase domain protein hydrolase MAG.T1.121_02277 1122132.AQYH01000006_gene3697 2.2e-46 192.6 Bacteria 3.1.2.32 ko:K20257 ko00405,ko01130,ko02024,ko02025,map00405,map01130,map02024,map02025 R11542 RC00014 ko00000,ko00001,ko01000 Bacteria COG0491@1,COG0491@2 NA|NA|NA GM Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid MAG.T1.121_02278 869210.Marky_1922 6e-112 410.6 Deinococcus-Thermus 3.6.3.17 ko:K02056 M00221 ko00000,ko00002,ko01000,ko02000 3.A.1.2 Bacteria 1WJH6@1297,COG1129@1,COG1129@2 NA|NA|NA G COG1129 ABC-type sugar transport system, ATPase component MAG.T1.121_02279 1382356.JQMP01000003_gene2219 2.4e-76 292.0 Thermomicrobia clpC GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0008150,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0040007,GO:0042802,GO:0042803,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0071944 ko:K03696 ko01100,map01100 ko00000,ko03110 Bacteria 27XGF@189775,2G5RA@200795,COG0542@1,COG0542@2 NA|NA|NA O Sigma-54 interaction domain MAG.T1.121_02280 479434.Sthe_0497 7e-141 507.3 Thermomicrobia radA ko:K04485 ko00000,ko03400 Bacteria 27XMK@189775,2G5TE@200795,COG1066@1,COG1066@2 NA|NA|NA L DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function MAG.T1.121_02281 479434.Sthe_0498 1.6e-85 323.2 Thermomicrobia murG 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 GT28 iLJ478.TM0232 Bacteria 27YX8@189775,2G6EH@200795,COG0707@1,COG0707@2 NA|NA|NA M Glycosyltransferase family 28 N-terminal domain MAG.T1.121_02282 1223543.GP2_001_00220 5.4e-20 104.4 Gordoniaceae lspA GO:0006464,GO:0006497,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009405,GO:0009987,GO:0019538,GO:0034645,GO:0036211,GO:0040007,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044419,GO:0051704,GO:0071704,GO:1901564,GO:1901566,GO:1901576 3.4.23.36 ko:K03101 ko03060,map03060 ko00000,ko00001,ko01000,ko01002 Bacteria 2GKRX@201174,4GDUD@85026,COG0597@1,COG0597@2 NA|NA|NA MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins MAG.T1.121_02283 326427.Cagg_2289 1.2e-71 276.9 Chloroflexia rluD GO:0000027,GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022607,GO:0022613,GO:0022618,GO:0031118,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 5.4.99.23 ko:K06180 ko00000,ko01000,ko03009 iE2348C_1286.E2348C_2868,iECED1_1282.ECED1_3035,iECSF_1327.ECSF_2432 Bacteria 2G68N@200795,3758V@32061,COG0564@1,COG0564@2 NA|NA|NA J Responsible for synthesis of pseudouridine from uracil MAG.T1.121_02284 867845.KI911784_gene2182 1.6e-60 240.4 Chloroflexia 2.7.1.165 ko:K11529 ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200 M00346 R08572 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 Bacteria 2G5RZ@200795,374XG@32061,COG2379@1,COG2379@2 NA|NA|NA C PFAM MOFRL domain protein MAG.T1.121_02285 479434.Sthe_0507 1.7e-195 689.1 Chloroflexi ilvB 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 Bacteria 2G8BB@200795,COG0028@1,COG0028@2 NA|NA|NA EH Thiamine pyrophosphate protein TPP binding domain protein MAG.T1.121_02286 479434.Sthe_0508 2.3e-53 216.1 Thermomicrobia 3.2.2.1 ko:K01239,ko:K01250,ko:K12700 ko00230,ko00760,ko01100,map00230,map00760,map01100 R01245,R01273,R01677,R01770,R02143 RC00033,RC00063,RC00122,RC00318,RC00485 ko00000,ko00001,ko01000 Bacteria 27Y7I@189775,2G6R6@200795,COG1957@1,COG1957@2 NA|NA|NA F Inosine-uridine preferring nucleoside hydrolase MAG.T1.121_02287 479434.Sthe_0509 4.8e-36 157.9 Thermomicrobia ko:K02315 ko00000,ko03032 Bacteria 27Y60@189775,2GA06@200795,COG1484@1,COG1484@2 NA|NA|NA L DNA-dependent DNA replication MAG.T1.121_02288 1382356.JQMP01000003_gene2228 1.1e-79 303.5 Thermomicrobia hepT GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.5.1.30,2.5.1.83,2.5.1.90 ko:K00805,ko:K02251,ko:K02523,ko:K21275 ko00900,ko01110,ko02024,map00900,map01110,map02024 R09245,R09247,R09248 RC00279 ko00000,ko00001,ko01000,ko01006,ko02044 Bacteria 27XMM@189775,2G6IZ@200795,COG0142@1,COG0142@2 NA|NA|NA H Belongs to the FPP GGPP synthase family MAG.T1.121_02289 479434.Sthe_0511 3.3e-91 342.8 Thermomicrobia Bacteria 27XJ9@189775,2G81Y@200795,COG1306@1,COG1306@2 NA|NA|NA S Putative glycosyl hydrolase domain MAG.T1.121_02290 479434.Sthe_0513 7.7e-29 133.7 Thermomicrobia MA20_45160 ko:K13993 ko04141,map04141 ko00000,ko00001,ko03110 Bacteria 27YKK@189775,2G7BB@200795,COG0071@1,COG0071@2 NA|NA|NA O Belongs to the small heat shock protein (HSP20) family MAG.T1.121_02292 926550.CLDAP_03560 1.7e-58 233.0 Chloroflexi Bacteria 2G6FB@200795,COG2120@1,COG2120@2 NA|NA|NA S PFAM LmbE family protein MAG.T1.121_02293 479434.Sthe_2029 1.4e-31 142.9 Thermomicrobia cinA 3.5.1.42 ko:K03742,ko:K03743 ko00760,map00760 R02322 RC00100 ko00000,ko00001,ko01000 Bacteria 27YG1@189775,2G6U8@200795,COG1546@1,COG1546@2 NA|NA|NA S Competence-damaged protein MAG.T1.121_02294 479434.Sthe_2028 7.4e-151 540.4 Thermomicrobia pepR GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 27XSH@189775,2G672@200795,COG0612@1,COG0612@2 NA|NA|NA S Belongs to the peptidase M16 family MAG.T1.121_02295 479434.Sthe_2195 1.9e-86 325.9 Thermomicrobia nadC GO:0003674,GO:0003824,GO:0004514,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016020,GO:0016054,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0030312,GO:0034213,GO:0034641,GO:0034654,GO:0042737,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0072526,GO:0090407,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 1.4.3.16,2.4.2.19 ko:K00278,ko:K00767 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481,R03348 RC00006,RC02566,RC02877 ko00000,ko00001,ko00002,ko01000 Bacteria 27Z0A@189775,2G6GJ@200795,COG0157@1,COG0157@2 NA|NA|NA H Quinolinate phosphoribosyl transferase, N-terminal domain MAG.T1.121_02296 1382356.JQMP01000004_gene503 7.2e-55 221.5 Thermomicrobia enhA_2 Bacteria 27XVB@189775,2G6ZY@200795,COG1376@1,COG1376@2,COG5479@1,COG5479@2 NA|NA|NA M L,D-transpeptidase catalytic domain MAG.T1.121_02297 316274.Haur_2636 4.4e-16 91.7 Chloroflexia ko:K07156,ko:K14166 ko00000,ko02000 9.B.62.2 Bacteria 2GBCJ@200795,377PS@32061,COG2372@1,COG2372@2 NA|NA|NA S PFAM copper resistance protein CopC MAG.T1.121_02298 479434.Sthe_1365 1.7e-118 433.0 Thermomicrobia purD GO:0000166,GO:0003674,GO:0003824,GO:0004637,GO:0005488,GO:0005524,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.2.6,6.3.4.13,6.3.5.3 ko:K01945,ko:K01952,ko:K13713 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144,R04463,R04591 RC00010,RC00064,RC00090,RC00162,RC00166,RC01160 ko00000,ko00001,ko00002,ko01000 iECNA114_1301.ECNA114_3417,iECSF_1327.ECSF_3859,iJN746.PP_4823,iPC815.YPO3729,iSB619.SA_RS05245,iYO844.BSU06530 Bacteria 27XZU@189775,2G5ZE@200795,COG0151@1,COG0151@2 NA|NA|NA F Phosphoribosylglycinamide synthetase, C domain MAG.T1.121_02299 1499967.BAYZ01000033_gene1106 1.3e-31 143.3 Bacteria Bacteria COG3382@1,COG3382@2 NA|NA|NA J B3 4 domain protein MAG.T1.121_02300 1095772.CAHH01000073_gene551 1.2e-18 100.9 Actinobacteria ko:K06381 ko00000 Bacteria 2IEPH@201174,COG2385@1,COG2385@2 NA|NA|NA D SpoIID LytB domain protein MAG.T1.121_02301 479434.Sthe_0867 2.5e-38 165.6 Chloroflexi Bacteria 2G6K0@200795,COG2197@1,COG2197@2 NA|NA|NA K Two component transcriptional regulator, LuxR family MAG.T1.121_02302 1210908.HSB1_28770 8e-31 141.0 Euryarchaeota Archaea 2XV6R@28890,COG0596@1,arCOG01648@2157 NA|NA|NA S hydrolases or acyltransferases (alpha beta hydrolase superfamily) MAG.T1.121_02304 479434.Sthe_1954 9.5e-90 337.4 Thermomicrobia MA20_28495 3.5.1.16 ko:K01438 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R00669,R09107 RC00064,RC00300 ko00000,ko00001,ko00002,ko01000 Bacteria 27Z82@189775,2G8FI@200795,COG0624@1,COG0624@2 NA|NA|NA E Peptidase dimerisation domain MAG.T1.121_02306 525904.Tter_1162 4.6e-32 143.7 unclassified Bacteria yggX GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0033554,GO:0034599,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0070887 Bacteria 2NRHF@2323,COG2924@1,COG2924@2 NA|NA|NA CO Bacterial Fe(2+) trafficking MAG.T1.121_02307 42256.RradSPS_0564 1.9e-15 89.0 Bacteria ybeY ko:K07042 ko00000,ko03009 Bacteria COG0662@1,COG0662@2 NA|NA|NA G Cupin 2, conserved barrel domain protein MAG.T1.121_02308 861299.J421_6128 8e-135 487.3 Bacteria Bacteria COG0277@1,COG0277@2 NA|NA|NA C FAD linked oxidase domain protein MAG.T1.121_02309 479434.Sthe_3245 1.5e-192 679.9 Chloroflexi ko:K12952 ko00000,ko01000 3.A.3.23 Bacteria 2G5ZS@200795,COG0474@1,COG0474@2 NA|NA|NA P TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC MAG.T1.121_02311 886377.Murru_3436 1.7e-100 372.9 Flavobacteriia 3.4.13.19 ko:K01273 ko00000,ko00537,ko01000,ko01002,ko04147 Bacteria 1HZ07@117743,4NDYZ@976,COG2355@1,COG2355@2 NA|NA|NA E peptidase M19 MAG.T1.121_02312 1144310.PMI07_002545 1.4e-20 106.3 Rhizobiaceae ko:K07726 ko00000,ko03000 Bacteria 1N802@1224,2UGPM@28211,4BG8S@82115,COG2944@1,COG2944@2 NA|NA|NA K Helix-turn-helix XRE-family like proteins MAG.T1.121_02313 1540257.JQMW01000012_gene2642 2e-66 259.2 Clostridiaceae deoD_1 2.4.2.3 ko:K00757 ko00240,ko00983,ko01100,map00240,map00983,map01100 R01876,R02484,R08229 RC00063 ko00000,ko00001,ko01000 Bacteria 1TQ71@1239,2482S@186801,36GH9@31979,COG2820@1,COG2820@2 NA|NA|NA F Phosphorylase superfamily MAG.T1.121_02315 391735.Veis_2466 2e-14 85.5 Comamonadaceae doc ko:K07341 ko00000,ko02048 Bacteria 1N1FW@1224,2VTKH@28216,4AESN@80864,COG3654@1,COG3654@2 NA|NA|NA S TIGRFAM death-on-curing family protein MAG.T1.121_02316 309801.trd_1134 5.8e-67 261.5 Bacteria 2.9.1.1 ko:K01042 ko00450,ko00970,map00450,map00970 R08219 RC01246 ko00000,ko00001,ko01000 Bacteria COG1921@1,COG1921@2 NA|NA|NA E L-seryl-tRNASec selenium transferase activity MAG.T1.121_02317 485913.Krac_4124 1.6e-57 230.7 Bacteria Bacteria COG0793@1,COG0793@2 NA|NA|NA M Belongs to the peptidase S41A family MAG.T1.121_02319 1123322.KB904720_gene5131 2.7e-95 355.1 Actinobacteria Bacteria 2GT81@201174,COG4948@1,COG4948@2 NA|NA|NA M mandelate racemase muconate lactonizing MAG.T1.121_02320 1121924.ATWH01000019_gene2963 5.4e-60 238.0 Bacteria ko:K02030 M00236 ko00000,ko00002,ko02000 3.A.1.3 Bacteria COG0834@1,COG0834@2 NA|NA|NA ET amino acid transport MAG.T1.121_02321 1121924.ATWH01000019_gene2962 2.9e-64 251.9 Microbacteriaceae gltK ko:K02029 M00236 ko00000,ko00002,ko02000 3.A.1.3 Bacteria 2GJJ9@201174,4FMJG@85023,COG0765@1,COG0765@2 NA|NA|NA ET Binding-protein-dependent transport system inner membrane component MAG.T1.121_02322 1380394.JADL01000004_gene5895 7e-87 327.4 Rhodospirillales 3.6.3.21 ko:K02028 M00236 ko00000,ko00002,ko01000,ko02000 3.A.1.3 Bacteria 1MU9Q@1224,2JRUB@204441,2TQX2@28211,COG1126@1,COG1126@2 NA|NA|NA E polar amino acid transport system MAG.T1.121_02323 309801.trd_A0805 1.5e-19 103.6 Thermomicrobia 3.1.31.1 ko:K01174 ko00000,ko01000 Bacteria 27Z81@189775,2GB5G@200795,COG1525@1,COG1525@2 NA|NA|NA L Staphylococcal nuclease homologues MAG.T1.121_02324 324602.Caur_2289 8.9e-175 620.2 Chloroflexia rbsA 3.6.3.17 ko:K10441,ko:K10562 ko02010,map02010 M00212,M00220 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.9 Bacteria 2G649@200795,376BP@32061,COG1129@1,COG1129@2 NA|NA|NA P ABC transporter MAG.T1.121_02325 926550.CLDAP_40120 9.6e-88 330.5 Chloroflexi rhaP ko:K10560 ko02010,map02010 M00220 ko00000,ko00001,ko00002,ko02000 3.A.1.2.9 Bacteria 2G6EY@200795,COG1172@1,COG1172@2 NA|NA|NA G Belongs to the binding-protein-dependent transport system permease family MAG.T1.121_02326 324602.Caur_2287 2.4e-91 342.4 Chloroflexia ko:K10561 ko02010,map02010 M00220 ko00000,ko00001,ko00002,ko02000 3.A.1.2.9 Bacteria 2G6DF@200795,376MT@32061,COG1172@1,COG1172@2 NA|NA|NA G Belongs to the binding-protein-dependent transport system permease family MAG.T1.121_02327 926550.CLDAP_40100 3.2e-131 474.9 Chloroflexi ko:K10559 ko02010,map02010 M00220 ko00000,ko00001,ko00002,ko02000 3.A.1.2.9 Bacteria 2G8BJ@200795,COG1879@1,COG1879@2 NA|NA|NA G Periplasmic binding protein domain MAG.T1.121_02328 479434.Sthe_1305 7.3e-167 594.0 Thermomicrobia fhs GO:0000096,GO:0000097,GO:0000105,GO:0003674,GO:0003824,GO:0004329,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006144,GO:0006520,GO:0006547,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009108,GO:0009110,GO:0009112,GO:0009113,GO:0009256,GO:0009257,GO:0009396,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0016874,GO:0016879,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0052803,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.5.1.5,3.5.4.9,6.3.4.3 ko:K00288,ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00141,M00377 R00943,R01220,R01655 RC00026,RC00111,RC00202,RC00578 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 27Y4D@189775,2G5QS@200795,COG2759@1,COG2759@2 NA|NA|NA H Belongs to the formate--tetrahydrofolate ligase family MAG.T1.121_02329 479434.Sthe_3313 4.7e-15 88.2 Thermomicrobia Bacteria 27YGU@189775,2A4CF@1,2G9F0@200795,30SY3@2 NA|NA|NA S Yip1 domain MAG.T1.121_02333 1121272.KB903249_gene2215 1.8e-54 219.2 Actinobacteria 3.6.3.20 ko:K05816,ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00198,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.1,3.A.1.1.3 Bacteria 2GJCM@201174,COG3842@1,COG3842@2 NA|NA|NA E Belongs to the ABC transporter superfamily MAG.T1.121_02334 2074.JNYD01000004_gene4950 1.3e-91 343.2 Pseudonocardiales ko:K02025,ko:K02026,ko:K15771 ko02010,map02010 M00207,M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.2 Bacteria 2GJGB@201174,4DY7F@85010,COG1175@1,COG1175@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component MAG.T1.121_02335 1366050.N234_01110 2e-89 335.9 Burkholderiaceae ko:K02025,ko:K02026 M00207 ko00000,ko00002,ko02000 3.A.1.1 Bacteria 1KHPU@119060,1N4I0@1224,2VNEK@28216,COG0395@1,COG0395@2 NA|NA|NA P Carbohydrate ABC transporter membrane protein 2, CUT1 family MAG.T1.121_02336 1174528.JH992898_gene5323 2.7e-216 758.4 Cyanobacteria Bacteria 1G1I6@1117,COG0531@1,COG0531@2 NA|NA|NA E amino acid MAG.T1.121_02337 243090.RB3413 9.1e-52 210.7 Planctomycetes Bacteria 2IXCK@203682,COG0657@1,COG0657@2 NA|NA|NA I COG0657 Esterase lipase MAG.T1.121_02338 717785.HYPMC_3447 4.5e-08 65.5 Alphaproteobacteria Bacteria 1RADI@1224,2E61I@1,2U5E9@28211,330QS@2 NA|NA|NA MAG.T1.121_02341 1341151.ASZU01000008_gene1584 1.9e-94 352.8 Thermoactinomycetaceae msmX ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 ko00000,ko00001,ko00002,ko02000 3.A.1.1 Bacteria 1TP2M@1239,27BNY@186824,4HAMQ@91061,COG3842@1,COG3842@2 NA|NA|NA E Rad17 cell cycle checkpoint protein MAG.T1.121_02342 556261.HMPREF0240_04206 2.2e-61 242.7 Clostridiaceae ko:K02026 M00207 ko00000,ko00002,ko02000 3.A.1.1 Bacteria 1TRXW@1239,25C4N@186801,36FCS@31979,COG0395@1,COG0395@2 NA|NA|NA U Binding-protein-dependent transport system inner membrane component MAG.T1.121_02343 1499967.BAYZ01000009_gene5384 1.8e-61 243.0 Bacteria ko:K02025,ko:K15771 ko02010,map02010 M00207,M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.2 Bacteria COG1175@1,COG1175@2 NA|NA|NA P transmembrane transport MAG.T1.121_02344 556261.HMPREF0240_04204 1.3e-36 161.0 Clostridia ko:K02027 M00207 ko00000,ko00002,ko02000 3.A.1.1 Bacteria 1TQFZ@1239,24EHT@186801,COG1653@1,COG1653@2 NA|NA|NA G PFAM extracellular solute-binding protein family 1 MAG.T1.121_02345 479434.Sthe_1234 6.5e-72 278.1 Thermomicrobia Bacteria 27YXI@189775,2G7N8@200795,COG5476@1,COG5476@2 NA|NA|NA S MlrC C-terminus MAG.T1.121_02347 525904.Tter_0032 1.4e-189 669.8 unclassified Bacteria Bacteria 2NNZQ@2323,COG0531@1,COG0531@2 NA|NA|NA E Amino acid permease MAG.T1.121_02348 1245469.S58_18690 1.2e-33 150.6 Bradyrhizobiaceae sseA 2.8.1.1,2.8.1.2,4.4.1.8 ko:K01011,ko:K01760 ko00270,ko00450,ko00920,ko01100,ko01110,ko01120,ko01230,ko04122,map00270,map00450,map00920,map01100,map01110,map01120,map01230,map04122 M00017 R00782,R01286,R01931,R02408,R03105,R03106,R04941 RC00056,RC00069,RC00214,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko00002,ko01000 Bacteria 1MW4B@1224,2TR9R@28211,3JT1H@41294,COG2897@1,COG2897@2 NA|NA|NA P Rhodanese Homology Domain MAG.T1.121_02349 1382356.JQMP01000003_gene2026 5.9e-171 607.4 Thermomicrobia gltX 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 Bacteria 27XPN@189775,2G5WU@200795,COG0008@1,COG0008@2 NA|NA|NA J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) MAG.T1.121_02350 1229172.JQFA01000004_gene1013 8.6e-20 104.4 Cyanobacteria ko:K03668 ko00000 Bacteria 1GA7U@1117,COG3187@1,COG3187@2 NA|NA|NA O META domain MAG.T1.121_02352 1123024.AUII01000001_gene3060 2e-32 146.4 Pseudonocardiales yjbC Bacteria 2GP2T@201174,4E7G3@85010,COG0454@1,COG0456@2 NA|NA|NA K Acetyltransferase (GNAT) domain MAG.T1.121_02355 485913.Krac_9866 2.8e-41 176.0 Bacteria Bacteria COG2141@1,COG2141@2 NA|NA|NA C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases MAG.T1.121_02356 316274.Haur_2907 7.3e-09 67.8 Chloroflexia ko:K06386,ko:K19304,ko:K21471 ko00000,ko01000,ko01002,ko01011 1.A.34.1.1 Bacteria 2GA1R@200795,375F7@32061,COG0739@1,COG0739@2 NA|NA|NA M PFAM peptidase MAG.T1.121_02357 1454007.JAUG01000055_gene3325 6.4e-35 155.6 Sphingobacteriia bipA ko:K20276 ko02024,map02024 ko00000,ko00001 Bacteria 1J0N1@117747,4PKBQ@976,COG2373@1,COG2373@2,COG3209@1,COG3209@2,COG4547@1,COG4547@2,COG5384@1,COG5384@2 NA|NA|NA M conserved repeat domain protein MAG.T1.121_02358 879212.DespoDRAFT_01458 1.1e-72 282.3 delta/epsilon subdivisions Bacteria 1R1K7@1224,42W43@68525,COG0823@1,COG0823@2 NA|NA|NA U Domain of unknown function (DUF4214) MAG.T1.121_02359 1234595.C725_2403 3.3e-55 224.2 unclassified Alphaproteobacteria 3.1.4.46 ko:K01126 ko00564,map00564 R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 Bacteria 1PHWK@1224,2V8XH@28211,4BT4V@82117,COG2340@1,COG2340@2,COG2931@1,COG2931@2,COG4254@1,COG4254@2 NA|NA|NA Q Domain of unknown function (DUF4114) MAG.T1.121_02360 1211114.ALIP01000126_gene285 3e-31 141.4 Xanthomonadales Bacteria 1MZGQ@1224,1S7TT@1236,1X6DP@135614,COG0859@1,COG0859@2 NA|NA|NA M PFAM glycosyl transferase family 9 MAG.T1.121_02361 331869.BAL199_17368 1.3e-62 247.7 unclassified Alphaproteobacteria Bacteria 1MUZK@1224,2TS0U@28211,4BS5N@82117,COG0457@1,COG0457@2,COG0859@1,COG0859@2 NA|NA|NA M TPR repeat MAG.T1.121_02363 479434.Sthe_3303 1.3e-83 316.6 Thermomicrobia ko:K02034,ko:K15582 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 27YYH@189775,2GA37@200795,COG1173@1,COG1173@2 NA|NA|NA EP Binding-protein-dependent transport system inner membrane component MAG.T1.121_02364 479434.Sthe_3304 2e-89 335.9 Thermomicrobia ko:K02033 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 27YS8@189775,2GBCI@200795,COG0601@1,COG0601@2 NA|NA|NA EP Binding-protein-dependent transport system inner membrane component MAG.T1.121_02365 479434.Sthe_3305 6.7e-144 517.7 Thermomicrobia ko:K02035 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 27YWN@189775,2G7N5@200795,COG0747@1,COG0747@2 NA|NA|NA E Bacterial extracellular solute-binding proteins, family 5 Middle MAG.T1.121_02366 401526.TcarDRAFT_2570 3e-91 342.4 Negativicutes Bacteria 1TPRV@1239,4H25G@909932,COG2768@1,COG2768@2 NA|NA|NA C Domain of unknown function (DUF2088) MAG.T1.121_02367 2074.JNYD01000001_gene5846 3.5e-68 266.9 Pseudonocardiales embR GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006355,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0018130,GO:0019219,GO:0019222,GO:0019538,GO:0019637,GO:0019693,GO:0030312,GO:0031323,GO:0031326,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051186,GO:0051188,GO:0051189,GO:0051252,GO:0055086,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0072521,GO:0080090,GO:0090407,GO:0097159,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1903506,GO:2000112,GO:2001141 Bacteria 2H57H@201174,4EF5W@85010,COG3629@1,COG3629@2,COG3899@1,COG3899@2 NA|NA|NA K Bacterial transcriptional activator domain MAG.T1.121_02369 384765.SIAM614_06838 1.8e-94 352.8 Alphaproteobacteria Bacteria 1MW38@1224,2TVAB@28211,COG0560@1,COG0560@2 NA|NA|NA E haloacid dehalogenase-like hydrolase MAG.T1.121_02370 29306.JOBE01000082_gene5081 2.6e-147 528.5 Actinobacteria MA20_04465 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 Bacteria 2GNZD@201174,COG0498@1,COG0498@2 NA|NA|NA E Threonine synthase MAG.T1.121_02371 309801.trd_A0349 5.8e-26 124.4 Thermomicrobia ko:K07023 ko00000 Bacteria 27YFJ@189775,2G72G@200795,COG1896@1,COG1896@2 NA|NA|NA S HD domain MAG.T1.121_02372 485913.Krac_2886 2.8e-36 159.1 Bacteria 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 Bacteria COG0412@1,COG0412@2 NA|NA|NA Q carboxymethylenebutenolidase activity MAG.T1.121_02374 383372.Rcas_3851 5e-31 140.2 Chloroflexia Bacteria 2GAK3@200795,3774Y@32061,COG1028@1,COG1028@2 NA|NA|NA IQ PFAM short-chain dehydrogenase reductase SDR MAG.T1.121_02375 479434.Sthe_2272 2.6e-33 149.1 Bacteria Bacteria 333S7@2,arCOG08992@1 NA|NA|NA MAG.T1.121_02376 309799.DICTH_0452 1.2e-54 219.9 Bacteria yoqW Bacteria COG2135@1,COG2135@2 NA|NA|NA S peptidase activity MAG.T1.121_02377 55952.BU52_14435 2.3e-52 212.2 Actinobacteria catA 1.13.11.1 ko:K03381 ko00361,ko00362,ko00364,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00364,map00623,map01100,map01120,map01220 M00568 R00817,R04258,R05299,R08114,R08115,R09134 RC00388,RC00535,RC01366 ko00000,ko00001,ko00002,ko01000 Bacteria 2GNNC@201174,COG3485@1,COG3485@2 NA|NA|NA Q catechol 1,2-dioxygenase MAG.T1.121_02378 1536775.H70737_11470 4.1e-53 214.9 Paenibacillaceae pepE GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564 3.4.11.2,3.4.13.21 ko:K01256,ko:K05995 ko00480,ko01100,map00480,map01100 R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 Bacteria 1TRBA@1239,26W9N@186822,4HB19@91061,COG3340@1,COG3340@2 NA|NA|NA E Belongs to the peptidase S51 family MAG.T1.121_02381 1206731.BAGB01000172_gene295 1.5e-72 281.2 Nocardiaceae Bacteria 2GIZ1@201174,4FUTU@85025,COG0515@1,COG0515@2,COG3903@1,COG3903@2 NA|NA|NA K activity, protein serine threonine kinase activity, protein-tyrosine kinase activity, ATP binding, regulation of transcription, DNA-dependent, protein amino acid phosphorylation MAG.T1.121_02382 1382306.JNIM01000001_gene846 1.1e-09 69.3 Bacteria ko:K09932 ko00000 Bacteria COG3224@1,COG3224@2 NA|NA|NA MAG.T1.121_02383 1227499.C493_06592 1.2e-130 473.4 Halobacteria Archaea 23SGR@183963,2XT8F@28890,COG0277@1,arCOG00337@2157 NA|NA|NA C COG0277 FAD FMN-containing dehydrogenases MAG.T1.121_02384 383372.Rcas_1702 1.6e-25 122.9 Chloroflexia Bacteria 2G90F@200795,377N7@32061,COG4636@1,COG4636@2 NA|NA|NA S Putative restriction endonuclease MAG.T1.121_02386 1232410.KI421413_gene831 2.4e-08 65.5 Deltaproteobacteria Bacteria 1PD2Z@1224,2WSQ7@28221,42XAJ@68525,COG5611@1,COG5611@2 NA|NA|NA S PIN domain MAG.T1.121_02387 1464048.JNZS01000012_gene3474 9.5e-73 280.0 Micromonosporales 1.5.1.40 ko:K06988 ko00000,ko01000 Bacteria 2GJF5@201174,4DD06@85008,COG2085@1,COG2085@2 NA|NA|NA S NADP oxidoreductase coenzyme F420-dependent MAG.T1.121_02388 450380.JPSY01000001_gene1420 1.7e-159 568.9 Microbacteriaceae XK27_00915 Bacteria 2GKCU@201174,4FKJ2@85023,COG2141@1,COG2141@2 NA|NA|NA C Luciferase-like monooxygenase MAG.T1.121_02389 1157637.KB892121_gene316 2.2e-47 195.3 Actinobacteria Bacteria 2GP6A@201174,COG1846@1,COG1846@2 NA|NA|NA K transcriptional regulator MAG.T1.121_02391 1123251.ATWM01000009_gene2855 2.5e-264 918.3 Intrasporangiaceae glgP GO:0000272,GO:0003674,GO:0003824,GO:0004645,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0005977,GO:0005980,GO:0006073,GO:0006091,GO:0006112,GO:0008144,GO:0008150,GO:0008152,GO:0008184,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0015980,GO:0016052,GO:0016740,GO:0016757,GO:0016758,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901575 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 R02111 ko00000,ko00001,ko01000 GT35 Bacteria 2GIVZ@201174,4FFHK@85021,COG0058@1,COG0058@2 NA|NA|NA G phosphorylase MAG.T1.121_02392 357808.RoseRS_1830 7.4e-125 453.8 Chloroflexia lacD GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0006790,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016832,GO:0019637,GO:0034308,GO:0042180,GO:0044237,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0061595,GO:0061720,GO:0071704,GO:1901135,GO:1901136,GO:1901575,GO:1901615,GO:1902776,GO:1902777 4.1.2.40,4.1.2.57 ko:K01635,ko:K01671 ko00052,ko01100,ko02024,map00052,map01100,map02024 R01069,R10760 RC00438,RC00439 ko00000,ko00001,ko01000 Bacteria 2G5XK@200795,376YA@32061,COG3684@1,COG3684@2 NA|NA|NA G PFAM deoxyribose-phosphate aldolase phospho-2-dehydro-3-deoxyheptonate aldolase MAG.T1.121_02393 357808.RoseRS_0387 4.4e-143 514.2 Chloroflexia gap 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 Bacteria 2G5MG@200795,375CC@32061,COG0057@1,COG0057@2 NA|NA|NA C Belongs to the glyceraldehyde-3-phosphate dehydrogenase family MAG.T1.121_02394 525904.Tter_2475 6.9e-102 377.5 unclassified Bacteria ko:K02529 ko00000,ko03000 Bacteria 2NR26@2323,COG1609@1,COG1609@2 NA|NA|NA K Periplasmic binding protein LacI transcriptional regulator MAG.T1.121_02396 1169161.KB897716_gene5985 1.7e-69 269.6 Actinobacteria Bacteria 2GMTH@201174,COG0395@1,COG0395@2 NA|NA|NA G ABC transporter (Permease) MAG.T1.121_02397 1120950.KB892739_gene3981 6.7e-80 304.3 Propionibacteriales ko:K02025,ko:K15771 ko02010,map02010 M00207,M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.2 Bacteria 2GKBJ@201174,4DWRD@85009,COG1175@1,COG1175@2 NA|NA|NA P PFAM binding-protein-dependent transport systems inner membrane component MAG.T1.121_02398 1169161.KB897716_gene5983 1.9e-80 306.6 Actinobacteria Bacteria 2GK9G@201174,COG1653@1,COG1653@2 NA|NA|NA G ABC transporter substrate-binding protein MAG.T1.121_02400 479434.Sthe_1394 1.7e-93 350.1 Thermomicrobia tig GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944 ko:K03545 ko00000 Bacteria 27XNF@189775,2G6GA@200795,COG0544@1,COG0544@2 NA|NA|NA D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase MAG.T1.121_02401 1382356.JQMP01000004_gene223 2.2e-82 312.0 Thermomicrobia clpP 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 ko00000,ko00001,ko01000,ko01002 Bacteria 27Y58@189775,2G6BN@200795,COG0740@1,COG0740@2 NA|NA|NA O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins MAG.T1.121_02402 1382356.JQMP01000004_gene222 4.9e-171 607.4 Thermomicrobia clpX GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 ko:K03544 ko04112,map04112 ko00000,ko00001,ko03110 Bacteria 27XW6@189775,2G661@200795,COG1219@1,COG1219@2 NA|NA|NA O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP MAG.T1.121_02403 1163408.UU9_06734 4.9e-25 121.7 Bacteria Bacteria 2BWQH@1,33MA8@2 NA|NA|NA MAG.T1.121_02404 756067.MicvaDRAFT_5065 2.7e-52 211.8 Oscillatoriales Bacteria 1G53U@1117,1HCMX@1150,COG3335@1,COG3335@2 NA|NA|NA L DDE superfamily endonuclease MAG.T1.121_02405 1330700.JQNC01000003_gene601 1.4e-39 169.5 Deinococcus-Thermus Bacteria 1WJUC@1297,COG3415@1,COG3415@2 NA|NA|NA L Winged helix-turn helix MAG.T1.121_02406 309801.trd_1745 8.9e-156 557.0 Thermomicrobia Bacteria 27YXI@189775,2G7N8@200795,COG5476@1,COG5476@2 NA|NA|NA S MlrC C-terminus MAG.T1.121_02407 309801.trd_1744 3e-95 355.1 Thermomicrobia 2.3.1.247 ko:K18013 ko00310,map00310 R10564 RC02728,RC03199 ko00000,ko00001,ko01000 Bacteria 27YYT@189775,2G81V@200795,COG3246@1,COG3246@2 NA|NA|NA S beta-keto acid cleavage enzyme MAG.T1.121_02408 485913.Krac_6688 4.9e-48 197.6 Chloroflexi yccU GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 ko:K06929 ko00000 Bacteria 2G6VU@200795,COG1832@1,COG1832@2 NA|NA|NA S PFAM CoA-binding domain protein MAG.T1.121_02409 1128421.JAGA01000003_gene3456 7.3e-124 450.3 unclassified Bacteria cysD 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 Bacteria 2NQN4@2323,COG2873@1,COG2873@2 NA|NA|NA E Cys/Met metabolism PLP-dependent enzyme MAG.T1.121_02410 743719.PaelaDRAFT_5002 9.2e-66 257.3 Paenibacillaceae ko:K02025,ko:K15771 ko02010,map02010 M00207,M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.2 Bacteria 1TREE@1239,26SX3@186822,4HBEF@91061,COG1175@1,COG1175@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component MAG.T1.121_02411 1200792.AKYF01000019_gene4761 1.4e-75 290.4 Paenibacillaceae ko:K02027 M00207 ko00000,ko00002,ko02000 3.A.1.1 Bacteria 1TRIH@1239,274K4@186822,4HA29@91061,COG1653@1,COG1653@2 NA|NA|NA G Bacterial extracellular solute-binding protein MAG.T1.121_02412 926550.CLDAP_16460 1.5e-100 372.9 Chloroflexi ko:K02033 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 iLJ478.TM1747 Bacteria 2G61A@200795,COG0601@1,COG0601@2 NA|NA|NA P PFAM binding-protein-dependent transport systems inner membrane component MAG.T1.121_02413 926550.CLDAP_16470 1.2e-76 293.5 Chloroflexi ko:K02034,ko:K15582 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 2G612@200795,COG1173@1,COG1173@2 NA|NA|NA EP PFAM binding-protein-dependent transport systems inner membrane component MAG.T1.121_02414 926550.CLDAP_16450 8.8e-142 510.8 Chloroflexi ko:K02035,ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 2G81P@200795,COG4166@1,COG4166@2 NA|NA|NA E PFAM extracellular solute-binding protein, family 5 MAG.T1.121_02415 926550.CLDAP_16450 3e-142 512.3 Chloroflexi ko:K02035,ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 2G81P@200795,COG4166@1,COG4166@2 NA|NA|NA E PFAM extracellular solute-binding protein, family 5 MAG.T1.121_02416 1828.JOKB01000008_gene566 8.6e-36 156.8 Nocardiaceae Bacteria 2GQ40@201174,4G2RM@85025,COG0251@1,COG0251@2 NA|NA|NA J YjgF/chorismate_mutase-like, putative endoribonuclease MAG.T1.121_02417 525904.Tter_1939 4.8e-148 531.2 unclassified Bacteria bglA1 3.2.1.21 ko:K05350 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 Bacteria 2NPRZ@2323,COG2723@1,COG2723@2 NA|NA|NA G Glycosyl hydrolase family 1 MAG.T1.121_02422 604331.AUHY01000012_gene2711 4.5e-100 371.3 Deinococcus-Thermus rfbB 4.1.1.35,4.2.1.46 ko:K01710,ko:K08678 ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00520,map00521,map00523,map00525,map01055,map01100,map01130 M00361,M00793 R01384,R06513 RC00402,RC00508 ko00000,ko00001,ko00002,ko01000 Bacteria 1WJB0@1297,COG0451@1,COG0451@2 NA|NA|NA GM GDP-mannose 4,6 dehydratase MAG.T1.121_02424 1121381.JNIV01000001_gene2893 4.5e-35 155.2 Deinococcus-Thermus 2.3.1.4 ko:K00621 ko00520,map00520 R02058 RC00004,RC00166 ko00000,ko00001,ko01000 Bacteria 1WMYB@1297,COG0454@1,COG0456@2 NA|NA|NA K FR47-like protein MAG.T1.121_02425 479434.Sthe_0015 1.7e-27 129.0 Thermomicrobia rimI 2.3.1.128 ko:K03789 ko00000,ko01000,ko03009 Bacteria 27YFS@189775,2GBA6@200795,COG0454@1,COG0456@2 NA|NA|NA K Acetyltransferase (GNAT) domain MAG.T1.121_02426 1123229.AUBC01000010_gene3373 1.1e-21 109.8 Bradyrhizobiaceae Bacteria 1N984@1224,2UBT7@28211,3JZ0R@41294,COG4828@1,COG4828@2 NA|NA|NA S Protein of unknown function (DUF1622) MAG.T1.121_02427 1117108.PAALTS15_22458 1.8e-46 192.6 Paenibacillaceae ko:K06867 ko00000 Bacteria 1V2DE@1239,27535@186822,4HHDC@91061,COG0666@1,COG0666@2 NA|NA|NA S Ankyrin repeat MAG.T1.121_02428 319225.Plut_1520 1.6e-27 129.4 Bacteria Bacteria COG2862@1,COG2862@2 NA|NA|NA S Uncharacterized protein family, UPF0114 MAG.T1.121_02429 1380394.JADL01000010_gene4202 1.5e-70 273.1 Rhodospirillales mmuM 2.1.1.10 ko:K00547,ko:K21169 ko00270,ko01059,ko01100,ko01110,ko01130,map00270,map01059,map01100,map01110,map01130 M00825 R00650 RC00003,RC00035 ko00000,ko00001,ko00002,ko01000 Bacteria 1QU2A@1224,2JQ6P@204441,2TS3P@28211,COG2040@1,COG2040@2 NA|NA|NA E Homocysteine S-methyltransferase MAG.T1.121_02430 1380394.JADL01000010_gene4202 9.6e-73 280.4 Rhodospirillales mmuM 2.1.1.10 ko:K00547,ko:K21169 ko00270,ko01059,ko01100,ko01110,ko01130,map00270,map01059,map01100,map01110,map01130 M00825 R00650 RC00003,RC00035 ko00000,ko00001,ko00002,ko01000 Bacteria 1QU2A@1224,2JQ6P@204441,2TS3P@28211,COG2040@1,COG2040@2 NA|NA|NA E Homocysteine S-methyltransferase MAG.T1.121_02431 479434.Sthe_2592 3.6e-227 794.3 Thermomicrobia ko:K01436,ko:K12941 ko00000,ko01000,ko01002 Bacteria 27YTQ@189775,2GBCW@200795,COG1473@1,COG1473@2 NA|NA|NA S amidohydrolase MAG.T1.121_02434 1120792.JAFV01000001_gene3508 9.2e-83 313.9 Alphaproteobacteria dhaa 4.1.2.42,4.1.3.41 ko:K18425,ko:K19967 ko00000,ko01000 Bacteria 1MVQE@1224,2TSQ3@28211,COG3616@1,COG3616@2 NA|NA|NA E amino acid aldolase or racemase MAG.T1.121_02435 479434.Sthe_3109 2.8e-134 485.7 Thermomicrobia glpD 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 R00848 RC00029 ko00000,ko00001,ko01000 iJN678.glpD Bacteria 27Y8H@189775,2G8C0@200795,COG0578@1,COG0578@2 NA|NA|NA C C-terminal domain of alpha-glycerophosphate oxidase MAG.T1.121_02436 1126627.BAWE01000004_gene2477 3e-46 192.2 Bradyrhizobiaceae Bacteria 1MVQW@1224,2TUA2@28211,3JUGJ@41294,COG1028@1,COG1028@2 NA|NA|NA IQ KR domain MAG.T1.121_02437 1122132.AQYH01000003_gene3059 3.1e-28 132.9 Rhizobiaceae ko:K11069 ko02010,map02010 M00299 ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 Bacteria 1NKD7@1224,2TYST@28211,4B6ZM@82115,COG0687@1,COG0687@2 NA|NA|NA E Spermidine putrescine ABC transporter substrate-binding protein MAG.T1.121_02439 479434.Sthe_2316 4.2e-83 315.1 Thermomicrobia Bacteria 27XUK@189775,2G9ZI@200795,COG2141@1,COG2141@2 NA|NA|NA C Luciferase-like monooxygenase MAG.T1.121_02445 797209.ZOD2009_22077 3.9e-13 83.2 Halobacteria Archaea 23X43@183963,2XZQY@28890,COG1520@1,arCOG02482@2157,arCOG02556@2157 NA|NA|NA S Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat MAG.T1.121_02446 479434.Sthe_2353 2.2e-24 119.4 Chloroflexi adsA ko:K03088 ko00000,ko03021 Bacteria 2G6X7@200795,COG1595@1,COG1595@2 NA|NA|NA K TIGRFAM RNA polymerase sigma factor, sigma-70 family MAG.T1.121_02447 1463936.JOJI01000061_gene7230 1.1e-95 357.5 Actinobacteria betA 1.1.99.1 ko:K00108 ko00260,ko01100,map00260,map01100 M00555 R01025 RC00087 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJAU@201174,COG2303@1,COG2303@2 NA|NA|NA E Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate MAG.T1.121_02448 1227497.C491_09539 8.4e-48 198.0 Halobacteria Archaea 23RX8@183963,2XW36@28890,COG1680@1,arCOG00771@2157 NA|NA|NA E COG1680 Beta-lactamase class C and other penicillin binding proteins MAG.T1.121_02449 518766.Rmar_2202 5.2e-130 471.5 Bacteroidetes Order II. Incertae sedis fadD8 6.2.1.12 ko:K01904 ko00130,ko00360,ko00940,ko01100,ko01110,map00130,map00360,map00940,map01100,map01110 M00039,M00137,M00350 R01616,R01943,R02194,R02221,R02255,R06583 RC00004,RC00131 ko00000,ko00001,ko00002,ko01000 Bacteria 1FJSN@1100069,4NFPF@976,COG0318@1,COG0318@2 NA|NA|NA IQ AMP-binding enzyme C-terminal domain MAG.T1.121_02450 526227.Mesil_0719 5.1e-97 362.5 Bacteria GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.7.11.1 ko:K08282,ko:K13419 ko00000,ko01000,ko01001 Bacteria COG2197@1,COG2197@2,COG3903@1,COG3903@2 NA|NA|NA K ADP binding MAG.T1.121_02451 552811.Dehly_0267 1.1e-63 250.0 Dehalococcoidia Bacteria 2G6JT@200795,34CJN@301297,COG0745@1,COG0745@2 NA|NA|NA K Transcriptional regulatory protein, C terminal MAG.T1.121_02452 326427.Cagg_2708 1.8e-49 203.4 Chloroflexia baeS 2.7.13.3 ko:K02484,ko:K07642,ko:K18143 ko01501,ko02020,map01501,map02020 M00450,M00645,M00646,M00648,M00649,M00655 ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022 Bacteria 2G60Q@200795,3762Z@32061,COG3850@1,COG3850@2,COG5002@1,COG5002@2 NA|NA|NA T histidine kinase HAMP region domain protein MAG.T1.121_02453 1123319.AUBE01000011_gene4439 1.2e-69 270.4 Actinobacteria 3.1.1.31 ko:K07404 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R02035 RC00537 ko00000,ko00001,ko00002,ko01000 Bacteria 2GNMK@201174,COG2706@1,COG2706@2 NA|NA|NA G 3-carboxymuconate cyclase MAG.T1.121_02454 1206729.BAFZ01000165_gene5670 6.5e-92 345.5 Nocardiaceae Bacteria 2GIZ1@201174,4FUTU@85025,COG0515@1,COG0515@2,COG3903@1,COG3903@2 NA|NA|NA K activity, protein serine threonine kinase activity, protein-tyrosine kinase activity, ATP binding, regulation of transcription, DNA-dependent, protein amino acid phosphorylation MAG.T1.121_02456 485913.Krac_9335 1.5e-86 327.4 Chloroflexi rhlE 3.6.4.13 ko:K11927 ko03018,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 2G5VR@200795,COG0513@1,COG0513@2 NA|NA|NA L Belongs to the DEAD box helicase family MAG.T1.121_02458 479434.Sthe_0091 7.3e-40 170.2 Chloroflexi vdlD 3.1.2.20 ko:K01073 ko00000,ko01000 Bacteria 2G7A6@200795,COG1607@1,COG1607@2 NA|NA|NA I PFAM thioesterase superfamily protein MAG.T1.121_02460 456442.Mboo_1720 1.1e-06 60.1 Methanomicrobia ko:K07451 ko00000,ko01000,ko02048 Archaea 2NB5Q@224756,2Y4MP@28890,COG3183@1,arCOG06811@2157 NA|NA|NA V HNH nucleases MAG.T1.121_02461 1242864.D187_003684 8.1e-18 97.1 Bacteria Bacteria COG1846@1,COG1846@2 NA|NA|NA K DNA-binding transcription factor activity MAG.T1.121_02462 1532557.JL37_11765 3.3e-76 292.0 Betaproteobacteria trzA 3.5.4.28,3.5.4.31 ko:K12960 ko00270,ko01100,map00270,map01100 R09660 RC00477 ko00000,ko00001,ko01000 Bacteria 1MVPA@1224,2VJ4R@28216,COG0402@1,COG0402@2 NA|NA|NA F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine MAG.T1.121_02465 1535287.JP74_05595 3.3e-90 338.2 Alphaproteobacteria Bacteria 1NPB8@1224,2U1M7@28211,COG5426@1,COG5426@2 NA|NA|NA S Putative glutamine amidotransferase MAG.T1.121_02466 525904.Tter_1938 6.9e-48 197.6 unclassified Bacteria iolE Bacteria 2NQSY@2323,COG1082@1,COG1082@2 NA|NA|NA G Xylose isomerase-like TIM barrel MAG.T1.121_02467 479434.Sthe_3326 3.6e-127 461.5 Thermomicrobia ko:K03733 ko00000,ko03036 Bacteria 27XHI@189775,2G94T@200795,COG4974@1,COG4974@2 NA|NA|NA L Belongs to the 'phage' integrase family MAG.T1.121_02469 526227.Mesil_3163 1.1e-41 177.2 Deinococcus-Thermus glpF ko:K02440,ko:K06188,ko:K09874 ko00000,ko02000 1.A.8,1.A.8.1,1.A.8.12,1.A.8.2 Bacteria 1WKA2@1297,COG0580@1,COG0580@2 NA|NA|NA G Belongs to the MIP aquaporin (TC 1.A.8) family MAG.T1.121_02472 479434.Sthe_3014 0.0 1095.1 Thermomicrobia mez_1 1.1.1.38 ko:K00027 ko00620,ko01200,ko02020,map00620,map01200,map02020 R00214 RC00105 ko00000,ko00001,ko01000 Bacteria 27XFK@189775,2G65R@200795,COG0281@1,COG0281@2 NA|NA|NA C Malic enzyme, NAD binding domain MAG.T1.121_02473 926560.KE387027_gene611 1.6e-92 346.3 Deinococcus-Thermus ko:K02031,ko:K02032 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 1WNDB@1297,COG1123@1,COG4172@2 NA|NA|NA P Oligopeptide/dipeptide transporter, C-terminal region MAG.T1.121_02475 345341.KUTG_01076 1.6e-92 345.9 Actinobacteria Bacteria 2GJSF@201174,COG0500@1,COG2226@2 NA|NA|NA Q methyltransferase MAG.T1.121_02476 138119.DSY0713 4.6e-198 698.0 Peptococcaceae recQ 3.6.4.12 ko:K03654 ko03018,map03018 ko00000,ko00001,ko01000,ko03400 Bacteria 1U3MS@1239,24BRN@186801,2643E@186807,COG0514@1,COG0514@2,COG1040@1,COG1040@2 NA|NA|NA L helicase superfamily c-terminal domain MAG.T1.121_02477 1297570.MESS4_720023 1e-49 204.1 Proteobacteria dprA ko:K04096 ko00000 Bacteria 1Q7YP@1224,COG0758@1,COG0758@2 NA|NA|NA LU Rossmann fold nucleotide-binding protein involved in DNA uptake MAG.T1.121_02481 479434.Sthe_1840 1.6e-102 379.4 Thermomicrobia accA 2.1.3.15,6.4.1.2 ko:K01962,ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 Bacteria 27XK7@189775,2G7S3@200795,COG0825@1,COG0825@2 NA|NA|NA I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA MAG.T1.121_02482 479434.Sthe_1839 2.9e-99 368.6 Thermomicrobia accD 2.1.3.15,6.4.1.2 ko:K01962,ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS20740 Bacteria 27XIF@189775,2G6E1@200795,COG0777@1,COG0777@2 NA|NA|NA I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA MAG.T1.121_02484 1041522.MCOL_V210955 2.2e-46 193.0 Mycobacteriaceae Bacteria 238A8@1762,2IAVM@201174,COG0596@1,COG0596@2 NA|NA|NA S Alpha beta hydrolase MAG.T1.121_02485 1242864.D187_007811 1e-60 240.4 Myxococcales mxcB Bacteria 1R4TD@1224,2WUMY@28221,2YTV1@29,42Y77@68525,COG2375@1,COG2375@2 NA|NA|NA P Siderophore-interacting protein MAG.T1.121_02486 479434.Sthe_0370 2.7e-42 178.3 Bacteria Bacteria 2DW90@1,33Z49@2 NA|NA|NA S Protein of unknown function (DUF1706) MAG.T1.121_02487 1268072.PSAB_08735 8e-26 123.2 Paenibacillaceae Bacteria 1VWTE@1239,26Y7V@186822,4HXHU@91061,COG5649@1,COG5649@2 NA|NA|NA S Domain of unknown function (DU1801) MAG.T1.121_02489 479431.Namu_3126 1e-13 82.8 Frankiales Bacteria 2I47E@201174,4EXGS@85013,COG2267@1,COG2267@2 NA|NA|NA I Secretory lipase MAG.T1.121_02490 1121468.AUBR01000025_gene2988 1.1e-87 330.5 Clostridia mloA GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0006464,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0018117,GO:0018175,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046983,GO:0070566,GO:0070733,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564 Bacteria 1TV5J@1239,24CRC@186801,COG3177@1,COG3177@2 NA|NA|NA S PFAM Fic DOC family MAG.T1.121_02492 1128421.JAGA01000001_gene2085 2.6e-18 100.1 Bacteria ko:K03265 ko03015,map03015 ko00000,ko00001,ko03012,ko03019 Bacteria COG1503@1,COG1503@2 NA|NA|NA J translation release factor activity MAG.T1.121_02493 224911.27355416 3.9e-37 161.4 Bradyrhizobiaceae Bacteria 1N03F@1224,2U57T@28211,3JYDA@41294,COG5646@1,COG5646@2 NA|NA|NA S InterPro IPR014922 MAG.T1.121_02494 526225.Gobs_3748 8.4e-26 122.9 Actinobacteria adaA 3.2.2.21 ko:K13529,ko:K13530,ko:K15051 ko03410,map03410 ko00000,ko00001,ko01000,ko03000,ko03400 Bacteria 2IQMA@201174,COG2169@1,COG2169@2 NA|NA|NA F Metal binding domain of Ada MAG.T1.121_02496 479434.Sthe_2353 1.7e-38 166.0 Chloroflexi adsA ko:K03088 ko00000,ko03021 Bacteria 2G6X7@200795,COG1595@1,COG1595@2 NA|NA|NA K TIGRFAM RNA polymerase sigma factor, sigma-70 family MAG.T1.121_02498 1122247.C731_1058 2.1e-28 132.5 Mycobacteriaceae ko:K03088 ko00000,ko03021 Bacteria 234V4@1762,2GJER@201174,COG1595@1,COG1595@2 NA|NA|NA K belongs to the sigma-70 factor family, ECF subfamily MAG.T1.121_02502 1380346.JNIH01000042_gene5558 2.5e-32 145.2 Actinobacteria ureB 3.5.1.5 ko:K01429,ko:K14048 ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120 R00131 RC02798,RC02806 ko00000,ko00001,ko01000 Bacteria 2IKR8@201174,COG0832@1,COG0832@2 NA|NA|NA E Belongs to the urease beta subunit family MAG.T1.121_02503 1194165.CAJF01000016_gene1387 6.8e-34 149.8 Actinobacteria ureA GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0019627,GO:0034641,GO:0042221,GO:0043419,GO:0043603,GO:0043605,GO:0044237,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0050896,GO:0051716,GO:0070887,GO:0071241,GO:0071248,GO:0071281,GO:0071704,GO:0071941,GO:1901564,GO:1901565,GO:1901575 3.5.1.5 ko:K01430,ko:K14048 ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120 R00131 RC02798,RC02806 ko00000,ko00001,ko01000 iYO844.BSU36660 Bacteria 2IKNA@201174,COG0831@1,COG0831@2 NA|NA|NA E belongs to the urease gamma subunit family MAG.T1.121_02504 67373.JOBF01000001_gene5861 2.4e-45 189.5 Actinobacteria yut GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0009987,GO:0015204,GO:0015265,GO:0015267,GO:0015840,GO:0016020,GO:0016043,GO:0019755,GO:0022607,GO:0022803,GO:0022838,GO:0022857,GO:0031224,GO:0031226,GO:0033218,GO:0033219,GO:0036094,GO:0042802,GO:0042886,GO:0042887,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0070206,GO:0070207,GO:0071702,GO:0071705,GO:0071840,GO:0071918,GO:0071944 ko:K08717 ko00000,ko02000 1.A.28.2 Bacteria 2I8JY@201174,COG4413@1,COG4413@2 NA|NA|NA E urea transporter MAG.T1.121_02505 749414.SBI_02868 3.8e-75 288.5 Actinobacteria 3.5.1.105 ko:K03478 ko00000,ko01000 Bacteria 2I8JK@201174,COG3394@1,COG3394@2 NA|NA|NA G YdjC-like protein MAG.T1.121_02507 626939.HMPREF9443_00399 1.5e-13 82.4 Negativicutes Bacteria 1VI98@1239,4H5JI@909932,COG3152@1,COG3152@2 NA|NA|NA S Protein of unknown function (DUF805) MAG.T1.121_02509 511051.CSE_09400 6.9e-49 201.4 Bacteria Bacteria COG1502@1,COG1502@2 NA|NA|NA I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol MAG.T1.121_02510 1382356.JQMP01000004_gene221 2.7e-09 68.6 Bacteria M1-431 Bacteria COG4283@1,COG4283@2 NA|NA|NA S Protein of unknown function (DUF1706) MAG.T1.121_02511 479434.Sthe_1947 4.3e-147 528.1 Thermomicrobia pntB 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 R00112 RC00001 ko00000,ko00001,ko01000 Bacteria 27Y0C@189775,2GB8C@200795,COG1282@1,COG1282@2 NA|NA|NA C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane MAG.T1.121_02512 479434.Sthe_1946 6.4e-29 133.3 Thermomicrobia pntA GO:0000166,GO:0003674,GO:0003824,GO:0003957,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0008746,GO:0008750,GO:0009117,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016652,GO:0019362,GO:0019637,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0046483,GO:0046496,GO:0046983,GO:0048037,GO:0050661,GO:0050662,GO:0051179,GO:0051186,GO:0051234,GO:0051287,GO:0055085,GO:0055086,GO:0055114,GO:0070403,GO:0070404,GO:0071704,GO:0071944,GO:0072524,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1902600 1.6.1.1,1.6.1.2 ko:K00322,ko:K00324 ko00760,ko01100,map00760,map01100 R00112 RC00001 ko00000,ko00001,ko01000 iEcE24377_1341.EcE24377A_1810 Bacteria 27YI1@189775,2GBAD@200795,COG3288@1,COG3288@2 NA|NA|NA C 4TM region of pyridine nucleotide transhydrogenase, mitoch MAG.T1.121_02513 479434.Sthe_1945 5.3e-111 407.9 Thermomicrobia pntA GO:0000166,GO:0003674,GO:0005488,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0051287,GO:0070403,GO:0097159,GO:1901265,GO:1901363 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 R00112 RC00001 ko00000,ko00001,ko01000 Bacteria 27XYV@189775,2GB86@200795,COG3288@1,COG3288@2 NA|NA|NA C Alanine dehydrogenase/PNT, N-terminal domain MAG.T1.121_02517 479434.Sthe_0291 4.3e-197 694.9 Thermomicrobia mrcB 2.4.1.129,3.4.16.4 ko:K05365 ko00550,map00550 R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 GT51 Bacteria 27XN3@189775,2G5ZG@200795,COG0744@1,COG0744@2 NA|NA|NA M Transglycosylase MAG.T1.121_02519 1382356.JQMP01000003_gene1910 1.6e-98 366.7 Thermomicrobia 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 27XNB@189775,2G7RK@200795,COG0304@1,COG0304@2 NA|NA|NA I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP MAG.T1.121_02520 401053.AciPR4_0444 6.3e-15 87.4 Acidobacteriia Bacteria 2JJGU@204432,3Y501@57723,COG2318@1,COG2318@2 NA|NA|NA S DinB superfamily MAG.T1.121_02521 926569.ANT_28260 2.5e-13 81.6 Chloroflexi Bacteria 2ED2V@1,2GBPF@200795,32VHB@2 NA|NA|NA S Protein of unknown function (DUF2568) MAG.T1.121_02522 356851.JOAN01000018_gene5624 1.5e-82 313.2 Micromonosporales 1.13.12.16,1.3.1.9 ko:K00459,ko:K02371 ko00061,ko00910,ko01100,ko01212,map00061,map00910,map01100,map01212 M00083 R00025,R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765 RC00052,RC00076,RC02541,RC02759 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 2GKA6@201174,4DDW3@85008,COG2070@1,COG2070@2 NA|NA|NA S Nitronate monooxygenase MAG.T1.121_02523 1382306.JNIM01000001_gene2721 1.3e-107 396.4 Bacteria Bacteria COG0826@1,COG0826@2 NA|NA|NA O peptidase U32 MAG.T1.121_02525 309801.trd_1134 3e-90 339.0 Bacteria 2.9.1.1 ko:K01042 ko00450,ko00970,map00450,map00970 R08219 RC01246 ko00000,ko00001,ko01000 Bacteria COG1921@1,COG1921@2 NA|NA|NA E L-seryl-tRNASec selenium transferase activity MAG.T1.121_02526 1254432.SCE1572_05015 2.4e-144 518.8 Deltaproteobacteria ddc Bacteria 1MWUX@1224,2WKFB@28221,42MYA@68525,COG0076@1,COG0076@2 NA|NA|NA E PFAM Pyridoxal-dependent decarboxylase MAG.T1.121_02527 1380390.JIAT01000013_gene212 1.2e-12 82.0 Rubrobacteria Bacteria 2I4C3@201174,4CQSU@84995,COG0823@1,COG0823@2 NA|NA|NA U Involved in the tonB-independent uptake of proteins MAG.T1.121_02528 479434.Sthe_3071 1.9e-72 279.6 Thermomicrobia Bacteria 27Y7R@189775,2G8CA@200795,COG2141@1,COG2141@2 NA|NA|NA C Luciferase-like monooxygenase MAG.T1.121_02529 216594.MMAR_4950 0.0 1191.4 Mycobacteriaceae atsD GO:0000323,GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0004065,GO:0004098,GO:0005488,GO:0005509,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005764,GO:0005766,GO:0005773,GO:0005775,GO:0005783,GO:0005788,GO:0006629,GO:0006643,GO:0006664,GO:0006665,GO:0006687,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0008150,GO:0008152,GO:0008484,GO:0009987,GO:0012505,GO:0016192,GO:0016787,GO:0016788,GO:0030141,GO:0031410,GO:0031974,GO:0031982,GO:0031983,GO:0032940,GO:0034774,GO:0035578,GO:0036230,GO:0042119,GO:0042582,GO:0043167,GO:0043169,GO:0043202,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043299,GO:0043312,GO:0044237,GO:0044238,GO:0044255,GO:0044422,GO:0044424,GO:0044432,GO:0044433,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0046872,GO:0046903,GO:0050896,GO:0051179,GO:0051234,GO:0060205,GO:0070013,GO:0071704,GO:0097708,GO:0099503,GO:1901135,GO:1901564,GO:1903509 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 Bacteria 233CA@1762,2GJ8H@201174,COG3119@1,COG3119@2 NA|NA|NA P thought to play an important role in the mineralization of sulfates catalytic activity a phenol sulfate H2O a phenol sulfate MAG.T1.121_02530 1134445.AJJM01000005_gene3215 8.2e-07 61.2 Actinobacteria Bacteria 2I2UM@201174,COG3393@1,COG3393@2 NA|NA|NA S -acetyltransferase MAG.T1.121_02533 309801.trd_1311 4.1e-22 110.5 Thermomicrobia cysO GO:0000096,GO:0000097,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0019344,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.80,2.8.1.11 ko:K03636,ko:K21147 ko04122,map04122 R07459,R07461 RC00043 ko00000,ko00001,ko01000 Bacteria 27Z8W@189775,2GBBB@200795,COG1977@1,COG1977@2 NA|NA|NA H ThiS family MAG.T1.121_02534 269799.Gmet_1569 5.6e-15 87.4 Deltaproteobacteria mec 3.13.1.6 ko:K21140 ko04122,map04122 R11524 RC00064,RC00090 ko00000,ko00001,ko01000 Bacteria 1N3TI@1224,2WW9Z@28221,42TY4@68525,COG1310@1,COG1310@2 NA|NA|NA S SMART Mov34 MPN PAD-1 family protein MAG.T1.121_02535 525909.Afer_0728 7.4e-129 467.2 Acidimicrobiia moeB GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006732,GO:0006777,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008146,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009108,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0016782,GO:0018130,GO:0019344,GO:0019538,GO:0019637,GO:0019720,GO:0019752,GO:0020012,GO:0030312,GO:0030682,GO:0042783,GO:0043170,GO:0043207,GO:0043436,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051189,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0061605,GO:0070566,GO:0071704,GO:0071944,GO:0075136,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.73,2.7.7.80,2.8.1.11,3.1.2.6 ko:K01069,ko:K03148,ko:K21029,ko:K21147 ko00620,ko00730,ko01100,ko04122,map00620,map00730,map01100,map04122 R01736,R07459,R07461 RC00004,RC00043,RC00137 ko00000,ko00001,ko01000 Bacteria 2GJB6@201174,4CMRS@84992,COG0476@1,COG0476@2,COG0607@1,COG0607@2 NA|NA|NA HP ThiF family MAG.T1.121_02536 1165841.SULAR_08302 5e-07 60.1 Proteobacteria Bacteria 1NJYU@1224,2EKUK@1,33EI9@2 NA|NA|NA S 2TM domain MAG.T1.121_02538 1283283.ATXA01000008_gene3187 5.2e-18 97.8 Frankiales Bacteria 2IFQ5@201174,4ET5T@85013,COG4803@1,COG4803@2 NA|NA|NA S membrane protein of uknown function UCP014873 MAG.T1.121_02539 479434.Sthe_0034 6.9e-106 391.0 Thermomicrobia megL 2.5.1.48,2.5.1.49,4.4.1.11,4.4.1.8 ko:K01739,ko:K01740,ko:K01760,ko:K01761,ko:K10764 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00654,R00782,R00999,R01286,R01287,R01288,R02408,R02508,R03217,R03260,R04770,R04859,R04941,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02821,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 Bacteria 27Y2Y@189775,2G684@200795,COG0626@1,COG0626@2 NA|NA|NA E Cys/Met metabolism PLP-dependent enzyme MAG.T1.121_02540 927677.ALVU02000001_gene1248 3.3e-17 94.7 Cyanobacteria Bacteria 1GBKD@1117,COG5654@1,COG5654@2 NA|NA|NA S RES MAG.T1.121_02541 102232.GLO73106DRAFT_00022450 2.8e-15 88.2 Bacteria ko:K07726 ko00000,ko03000 Bacteria COG2944@1,COG2944@2 NA|NA|NA K sequence-specific DNA binding MAG.T1.121_02542 66692.ABC3097 3.4e-17 95.5 Bacillus atl 3.2.1.96,3.4.17.14,3.5.1.28,6.1.1.12 ko:K01227,ko:K01876,ko:K07260,ko:K11060,ko:K13714,ko:K21472 ko00511,ko00550,ko00970,ko01100,ko01502,ko02020,map00511,map00550,map00970,map01100,map01502,map02020 M00359,M00360,M00651 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01002,ko01007,ko01011,ko01504,ko02042,ko03016,ko03029 GH73 Bacteria 1UI28@1239,1ZC2V@1386,4ISBN@91061,COG3103@1,COG3103@2,COG3807@1,COG3807@2,COG4193@1,COG4193@2 NA|NA|NA G Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase MAG.T1.121_02543 402626.Rpic_0079 6.9e-74 284.6 Burkholderiaceae ltrA Bacteria 1K4R6@119060,1MW5F@1224,2VMW0@28216,COG4292@1,COG4292@2 NA|NA|NA S Bacterial low temperature requirement A protein (LtrA) MAG.T1.121_02544 595460.RRSWK_06573 4.9e-08 65.9 Planctomycetes Bacteria 2IXD2@203682,COG1520@1,COG1520@2 NA|NA|NA S PQQ-like domain MAG.T1.121_02545 926550.CLDAP_09210 1e-34 153.3 Chloroflexi Bacteria 2G77R@200795,COG2318@1,COG2318@2 NA|NA|NA S DinB superfamily MAG.T1.121_02546 717605.Theco_0542 3.8e-94 351.7 Paenibacillaceae uxuA 4.2.1.8 ko:K01686 ko00040,ko01100,map00040,map01100 M00061 R05606 RC00543 ko00000,ko00001,ko00002,ko01000 Bacteria 1TP5F@1239,26TTG@186822,4H9UR@91061,COG1312@1,COG1312@2 NA|NA|NA G D-mannonate dehydratase (UxuA) MAG.T1.121_02547 1382306.JNIM01000001_gene3956 2.2e-78 298.9 Bacteria GO:0008150,GO:0040007 Bacteria COG4398@1,COG4398@2 NA|NA|NA E FIST C domain MAG.T1.121_02548 1382356.JQMP01000003_gene1402 1.9e-22 112.8 Thermomicrobia chpE ko:K06600,ko:K06895 ko00000,ko02000,ko02035 2.A.75.1,2.A.76 Bacteria 27ZC9@189775,2GBTW@200795,COG1280@1,COG1280@2 NA|NA|NA E LysE type translocator MAG.T1.121_02549 1114972.AUAW01000019_gene2032 3.9e-45 188.3 Lactobacillaceae XK27_07210 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 1TT38@1239,3F4C9@33958,4HCE2@91061,COG3382@1,COG3382@2 NA|NA|NA S B3 4 domain MAG.T1.121_02550 290512.Paes_1614 1.6e-25 122.9 Chlorobi Bacteria 1FF48@1090,COG2862@1,COG2862@2 NA|NA|NA S Uncharacterized protein family, UPF0114 MAG.T1.121_02551 1265490.JHVY01000008_gene3917 1.4e-164 585.9 Gammaproteobacteria MA20_01110 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0009987,GO:0016043,GO:0016829,GO:0016835,GO:0016836,GO:0022607,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0046872,GO:0047808,GO:0051259,GO:0051260,GO:0065003,GO:0071840 4.2.1.81 ko:K22209 ko00000,ko01000 Bacteria 1MVFW@1224,1RYMG@1236,COG4948@1,COG4948@2 NA|NA|NA M Belongs to the mandelate racemase muconate lactonizing enzyme family MAG.T1.121_02552 479434.Sthe_1513 9.5e-188 663.3 Thermomicrobia Bacteria 27YYI@189775,2G5YJ@200795,COG1574@1,COG1574@2 NA|NA|NA S Amidohydrolase family MAG.T1.121_02553 479434.Sthe_0330 7.8e-116 423.7 Thermomicrobia ispH 1.17.7.4,2.7.4.25 ko:K00945,ko:K02945,ko:K03527 ko00240,ko00900,ko01100,ko01110,ko01130,ko03010,map00240,map00900,map01100,map01110,map01130,map03010 M00052,M00096,M00178 R00158,R00512,R01665,R05884,R08210 RC00002,RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko03011 iIT341.HP0400,iLJ478.TM1444 Bacteria 27Y0F@189775,2G75Z@200795,COG0761@1,COG0761@2 NA|NA|NA IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis MAG.T1.121_02554 479434.Sthe_0329 5e-60 238.8 Chloroflexi Bacteria 2G8CG@200795,COG0726@1,COG0726@2 NA|NA|NA G Polysaccharide deacetylase MAG.T1.121_02555 479434.Sthe_0328 3.3e-44 185.3 Thermomicrobia 3.1.3.102,3.1.3.104,3.1.3.5 ko:K07025,ko:K08723,ko:K20862 ko00230,ko00240,ko00740,ko00760,ko01100,ko01110,map00230,map00240,map00740,map00760,map01100,map01110 M00125 R00183,R00511,R00548,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346,R07280 RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 27YDM@189775,2G73G@200795,COG1011@1,COG1011@2 NA|NA|NA S Haloacid dehalogenase-like hydrolase MAG.T1.121_02556 525904.Tter_0982 8.9e-14 84.0 Bacteria 2.7.8.5 ko:K00995 ko00564,ko01100,map00564,map01100 R01801 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 Bacteria COG0558@1,COG0558@2 NA|NA|NA I Belongs to the CDP-alcohol phosphatidyltransferase class-I family MAG.T1.121_02557 1157490.EL26_09965 8.5e-155 553.5 Alicyclobacillaceae kynU 3.7.1.3 ko:K01556 ko00380,ko01100,map00380,map01100 M00038 R00987,R02668,R03936 RC00284,RC00415 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQ8V@1239,279GB@186823,4HBE8@91061,COG3844@1,COG3844@2 NA|NA|NA E Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively MAG.T1.121_02558 1120936.KB907212_gene5097 3.7e-82 312.0 Streptosporangiales ko:K10439 ko02010,ko02030,map02010,map02030 M00212 ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 Bacteria 2GKZB@201174,4EM65@85012,COG1879@1,COG1879@2 NA|NA|NA G Periplasmic binding protein domain MAG.T1.121_02559 118166.JH976537_gene4085 1.5e-224 785.4 Oscillatoriales 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 Bacteria 1G3EC@1117,1H9S2@1150,COG3119@1,COG3119@2 NA|NA|NA P Sulfatase MAG.T1.121_02560 990285.RGCCGE502_14214 1.8e-106 392.5 Rhizobiaceae Bacteria 1MW38@1224,2TVAB@28211,4B7IE@82115,COG0560@1,COG0560@2 NA|NA|NA E haloacid dehalogenase-like hydrolase MAG.T1.121_02561 1121957.ATVL01000008_gene4371 5.6e-16 90.1 Cytophagia acyP GO:0003674,GO:0003824,GO:0003998,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016787,GO:0016817,GO:0016818,GO:0050896 3.6.1.7 ko:K01512 ko00620,ko00627,ko01120,map00620,map00627,map01120 R00317,R01421,R01515 RC00043 ko00000,ko00001,ko01000 iSB619.SA_RS07020,iSBO_1134.SBO_2263,iSF_1195.SF0969,iSFxv_1172.SFxv_1053,iS_1188.S1036 Bacteria 47RW5@768503,4NVB4@976,COG1254@1,COG1254@2 NA|NA|NA C Acylphosphatase MAG.T1.121_02562 316274.Haur_4825 3.8e-25 121.3 Chloroflexia yccU GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 ko:K06929 ko00000 Bacteria 2G6VU@200795,377ID@32061,COG1832@1,COG1832@2 NA|NA|NA S PFAM CoA-binding domain protein MAG.T1.121_02564 477641.MODMU_1166 6e-91 342.4 Frankiales Bacteria 2GIZ1@201174,4EUW7@85013,COG1813@1,COG1813@2,COG3903@1,COG3903@2 NA|NA|NA K Helix-turn-helix domain MAG.T1.121_02566 1297570.MESS4_750068 2.1e-115 422.5 Phyllobacteriaceae Bacteria 1NR5V@1224,2UQ6F@28211,43R8Z@69277,COG2041@1,COG2041@2 NA|NA|NA S Oxidoreductase molybdopterin binding domain MAG.T1.121_02567 1353531.AZNX01000030_gene5860 2e-17 97.1 Bacteria Bacteria 29828@1,2ZV88@2 NA|NA|NA MAG.T1.121_02568 1123508.JH636441_gene3129 1.1e-115 423.3 Planctomycetes pdhB 1.2.4.1,1.2.4.4 ko:K00162,ko:K11381,ko:K21416,ko:K21417 ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00036,M00307 R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2IYRX@203682,COG0022@1,COG0022@2,COG1071@1,COG1071@2 NA|NA|NA C Transketolase, pyrimidine binding domain MAG.T1.121_02569 1123508.JH636441_gene3128 3.4e-69 269.2 Planctomycetes acoC 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2IXCU@203682,COG0508@1,COG0508@2 NA|NA|NA C e3 binding domain MAG.T1.121_02570 288000.BBta_6172 4.6e-50 204.5 Bradyrhizobiaceae cah 4.2.1.1 ko:K01673 ko00910,map00910 R00132,R10092 RC02807 ko00000,ko00001,ko01000 Bacteria 1NGFN@1224,2TU0G@28211,3JSWW@41294,COG0288@1,COG0288@2 NA|NA|NA P Reversible hydration of carbon dioxide MAG.T1.121_02571 715226.ABI_16520 7.9e-55 220.3 Alphaproteobacteria ydeI Bacteria 1RJGC@1224,2U3AS@28211,COG4430@1,COG4430@2 NA|NA|NA S Protein conserved in bacteria MAG.T1.121_02572 1379270.AUXF01000005_gene755 2.5e-69 270.0 Bacteria Bacteria COG4805@1,COG4805@2 NA|NA|NA S Bacterial protein of unknown function (DUF885) MAG.T1.121_02573 765420.OSCT_1033 6e-11 75.1 Chloroflexia Bacteria 2DRD4@1,2G7IX@200795,33B9X@2,377N6@32061 NA|NA|NA MAG.T1.121_02574 573370.DMR_15210 1.8e-69 269.2 Deltaproteobacteria Bacteria 1QDCH@1224,28M2G@1,2WWWS@28221,2ZAGX@2,42UN0@68525 NA|NA|NA S Protein of unknown function (DUF3800) MAG.T1.121_02575 1123023.JIAI01000001_gene6882 1e-68 266.9 Actinobacteria Bacteria 2IJW8@201174,COG0684@1,COG0684@2 NA|NA|NA H Aldolase/RraA MAG.T1.121_02576 555079.Toce_1559 1.6e-83 316.6 Thermoanaerobacterales 4.4.1.11,4.4.1.8 ko:K01760,ko:K01761 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R00654,R00782,R01286,R02408,R04770,R04941 RC00056,RC00069,RC00196,RC00348,RC00382,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPC7@1239,25E6I@186801,42FZM@68295,COG0626@1,COG0626@2 NA|NA|NA E PFAM Cys Met metabolism MAG.T1.121_02578 1122132.AQYH01000005_gene435 4.6e-116 424.9 Rhizobiaceae ko:K02027 M00207 ko00000,ko00002,ko02000 3.A.1.1 Bacteria 1R5CC@1224,2TVID@28211,4BBBY@82115,COG1653@1,COG1653@2 NA|NA|NA G Bacterial extracellular solute-binding protein MAG.T1.121_02579 1535287.JP74_06220 5.8e-89 334.3 Alphaproteobacteria ko:K02026 M00207 ko00000,ko00002,ko02000 3.A.1.1 Bacteria 1N4I0@1224,2TT14@28211,COG0395@1,COG0395@2 NA|NA|NA G ABC-type sugar transport system, permease component MAG.T1.121_02580 1122132.AQYH01000005_gene437 4.2e-82 311.6 Rhizobiaceae ko:K02025,ko:K15771 ko02010,map02010 M00207,M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.2 Bacteria 1MWB7@1224,2TUAN@28211,4BCGW@82115,COG1175@1,COG1175@2 NA|NA|NA G Binding-protein-dependent transport system inner membrane component MAG.T1.121_02581 1123320.KB889563_gene6447 9.6e-27 127.5 Actinobacteria ko:K05799 ko00000,ko03000 Bacteria 2I91R@201174,COG2186@1,COG2186@2 NA|NA|NA K gntR family MAG.T1.121_02582 1122927.KB895415_gene4776 3.2e-206 724.9 Paenibacillaceae Bacteria 1U0CR@1239,271U4@186822,2Z9IC@2,4I9PP@91061,arCOG10801@1 NA|NA|NA MAG.T1.121_02584 266117.Rxyl_0131 2.6e-07 61.2 Bacteria copZ ko:K07089,ko:K07213 ko04978,map04978 ko00000,ko00001 Bacteria COG2608@1,COG2608@2 NA|NA|NA P mercury ion transmembrane transporter activity MAG.T1.121_02585 266117.Rxyl_0531 1.3e-57 229.9 Rubrobacteria Bacteria 2HP88@201174,4CT17@84995,COG1028@1,COG1028@2 NA|NA|NA IQ KR domain MAG.T1.121_02586 525904.Tter_0592 8.4e-89 333.6 Bacteria Bacteria COG2141@1,COG2141@2 NA|NA|NA C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases MAG.T1.121_02588 591157.SSLG_05862 1.4e-33 149.8 Actinobacteria Bacteria 2IFMC@201174,COG0662@1,COG0662@2,COG1396@1,COG1396@2 NA|NA|NA K transcriptional regulator MAG.T1.121_02590 1120956.JHZK01000035_gene1928 2e-22 111.7 Rhodobiaceae higA ko:K21498 ko00000,ko02048 Bacteria 1JPK9@119043,1N76J@1224,2UFXF@28211,COG3093@1,COG3093@2 NA|NA|NA K Helix-turn-helix XRE-family like proteins MAG.T1.121_02591 331869.BAL199_18541 1.9e-61 243.0 Alphaproteobacteria 3.5.3.6 ko:K01478 ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130 R00552 RC00177 ko00000,ko00001,ko01000 Bacteria 1R7NG@1224,2U4ZK@28211,COG1834@1,COG1834@2 NA|NA|NA E Amidinotransferase MAG.T1.121_02592 1128421.JAGA01000003_gene2818 1.6e-46 193.7 unclassified Bacteria rip3 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K06212,ko:K06402 ko00000,ko01000,ko01002,ko02000 1.A.16.1.1,1.A.16.1.3 Bacteria 2NPE1@2323,COG0517@1,COG0517@2,COG1994@1,COG1994@2 NA|NA|NA S Peptidase family M50 MAG.T1.121_02593 760568.Desku_3362 4.3e-12 77.8 Peptococcaceae Bacteria 1V8M3@1239,24MAG@186801,2654W@186807,COG2402@1,COG2402@2 NA|NA|NA S PIN domain MAG.T1.121_02595 479434.Sthe_0196 1.7e-67 263.1 Thermomicrobia fprA1 3.1.2.6 ko:K01069 ko00620,map00620 R01736 RC00004,RC00137 ko00000,ko00001,ko01000 Bacteria 27Y6V@189775,2G6KC@200795,COG0491@1,COG0491@2 NA|NA|NA S Metallo-beta-lactamase superfamily MAG.T1.121_02596 485913.Krac_12156 2.6e-24 118.6 Bacteria rsgA 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 Bacteria COG1162@1,COG1162@2 NA|NA|NA S GTPase activity MAG.T1.121_02597 671143.DAMO_1432 1.9e-30 139.4 unclassified Bacteria Bacteria 2NRM2@2323,COG4636@1,COG4636@2 NA|NA|NA S Putative restriction endonuclease MAG.T1.121_02598 485916.Dtox_3061 1.4e-36 159.8 Firmicutes Bacteria 1V424@1239,COG4636@1,COG4636@2 NA|NA|NA S Putative restriction endonuclease MAG.T1.121_02599 379731.PST_3895 2.2e-41 176.0 Pseudomonas stutzeri group Bacteria 1MWB6@1224,1RMZB@1236,1YZYP@136846,COG1028@1,COG1028@2 NA|NA|NA IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) MAG.T1.121_02603 1210908.HSB1_23170 1e-97 363.6 Halobacteria Archaea 23UJF@183963,2XVNY@28890,arCOG01637@1,arCOG01637@2157 NA|NA|NA Q Methyltransferase type 12 MAG.T1.121_02605 1210908.HSB1_23170 8.2e-106 390.6 Halobacteria Archaea 23UJF@183963,2XVNY@28890,arCOG01637@1,arCOG01637@2157 NA|NA|NA Q Methyltransferase type 12 MAG.T1.121_02606 1229780.BN381_430003 1.3e-145 523.9 unclassified Actinobacteria (class) ko:K06994 ko00000 Bacteria 2GJ5A@201174,3UX5E@52018,COG2409@1,COG2409@2 NA|NA|NA S drug exporters of the RND superfamily MAG.T1.121_02607 1380390.JIAT01000010_gene3597 1.4e-96 360.5 Rubrobacteria Bacteria 2GIUM@201174,4CRH0@84995,COG0477@1,COG0477@2 NA|NA|NA EGP Sugar (and other) transporter MAG.T1.121_02608 1267535.KB906767_gene3711 1.4e-18 99.8 Bacteria Bacteria COG1959@1,COG1959@2 NA|NA|NA K 2 iron, 2 sulfur cluster binding MAG.T1.121_02611 479434.Sthe_2353 4.8e-31 141.4 Chloroflexi adsA ko:K03088 ko00000,ko03021 Bacteria 2G6X7@200795,COG1595@1,COG1595@2 NA|NA|NA K TIGRFAM RNA polymerase sigma factor, sigma-70 family MAG.T1.121_02614 937777.Deipe_2397 3.9e-75 288.5 Bacteria Bacteria COG2378@1,COG2378@2 NA|NA|NA K regulation of single-species biofilm formation MAG.T1.121_02615 1238182.C882_0099 1.7e-120 439.1 Rhodospirillales Bacteria 1MZTP@1224,2JPPQ@204441,2TQKN@28211,COG3246@1,COG3246@2 NA|NA|NA S beta-keto acid cleavage enzyme MAG.T1.121_02616 1463841.JOIR01000011_gene2431 2.2e-15 91.3 Actinobacteria eamA ko:K15268 ko00000,ko02000 2.A.7.3.2 Bacteria 2H1HG@201174,COG0697@1,COG0697@2 NA|NA|NA EG Permeases of the drug metabolite transporter DMT superfamily MAG.T1.121_02617 926550.CLDAP_32470 2e-71 277.3 Chloroflexi Bacteria 2G8DG@200795,COG1807@1,COG1807@2 NA|NA|NA M Dolichyl-phosphate-mannose-protein mannosyltransferase MAG.T1.121_02618 479434.Sthe_0638 1.4e-23 115.2 Thermomicrobia Bacteria 27ZCU@189775,2G936@200795,COG4309@1,COG4309@2 NA|NA|NA S Uncharacterized conserved protein (DUF2249) MAG.T1.121_02619 479434.Sthe_0637 1.2e-127 463.4 Chloroflexi Bacteria 2G7C6@200795,COG3278@1,COG3278@2 NA|NA|NA O Belongs to the heme-copper respiratory oxidase family MAG.T1.121_02620 479434.Sthe_0636 1.2e-88 333.2 Chloroflexi Bacteria 2G7G3@200795,COG4309@1,COG4309@2 NA|NA|NA S Domain of unknown function (DUF1858) MAG.T1.121_02621 479434.Sthe_0635 1.7e-26 125.2 Chloroflexi ko:K02612 ko00360,ko01120,map00360,map01120 R09838 RC02690 ko00000,ko00001 Bacteria 2G75C@200795,COG2151@1,COG2151@2 NA|NA|NA S Pfam:DUF59 MAG.T1.121_02622 479434.Sthe_0628 9.4e-57 227.3 Chloroflexi nnrR ko:K01420,ko:K21564 ko00000,ko03000 Bacteria 2G70E@200795,COG0664@1,COG0664@2 NA|NA|NA K helix_turn_helix, cAMP Regulatory protein MAG.T1.121_02623 247490.KSU1_C1443 2.1e-183 648.7 Planctomycetes 3.1.26.11 ko:K00784 ko03013,map03013 ko00000,ko00001,ko01000,ko03016 Bacteria 2J27A@203682,COG1234@1,COG1234@2 NA|NA|NA S Beta-lactamase superfamily domain MAG.T1.121_02624 247490.KSU1_C1444 9.6e-122 443.4 Planctomycetes Bacteria 2IXBH@203682,COG0523@1,COG0523@2 NA|NA|NA S PFAM cobalamin synthesis protein MAG.T1.121_02626 680646.RMDY18_18000 1.1e-06 60.5 Actinobacteria Bacteria 2D8NJ@1,2HCDF@201174,32TRP@2 NA|NA|NA MAG.T1.121_02627 485913.Krac_7998 3.9e-48 198.4 Chloroflexi ydbM 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 iYO844.BSU04520 Bacteria 2G7W7@200795,COG1960@1,COG1960@2 NA|NA|NA C PFAM acyl-CoA dehydrogenase domain protein MAG.T1.121_02628 479434.Sthe_3144 1.2e-37 163.7 Thermomicrobia Bacteria 27YCV@189775,2G8K0@200795,COG0346@1,COG0346@2 NA|NA|NA E Glyoxalase-like domain MAG.T1.121_02630 479434.Sthe_3033 8.6e-35 153.7 Chloroflexi Bacteria 2G8IB@200795,COG0500@1,COG2226@2 NA|NA|NA Q PFAM Methyltransferase type 12 MAG.T1.121_02631 1150398.JIBJ01000011_gene2251 7.4e-31 141.0 Actinobacteria Bacteria 2DN8B@1,2ISPU@201174,32W2U@2 NA|NA|NA MAG.T1.121_02632 316067.Geob_0408 5.7e-64 251.9 Desulfuromonadales Bacteria 1MW8M@1224,2WJAU@28221,42QF7@68525,43VY7@69541,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor MAG.T1.121_02633 1035308.AQYY01000001_gene1244 8.9e-63 246.9 Peptococcaceae Bacteria 1TS81@1239,248XH@186801,261N5@186807,COG0745@1,COG0745@2 NA|NA|NA K Transcriptional regulatory protein, C terminal MAG.T1.121_02635 1122236.KB905144_gene2363 1.9e-20 106.3 Nitrosomonadales 3.6.1.27 ko:K19302 ko00550,map00550 R05627 RC00002 ko00000,ko00001,ko01000,ko01011 Bacteria 1PGC8@1224,2KP28@206350,2WAMJ@28216,COG0671@1,COG0671@2 NA|NA|NA I Acid phosphatase homologues MAG.T1.121_02639 745310.G432_21540 9.6e-10 70.1 Sphingomonadales ko:K07063 ko00000 Bacteria 1RCM5@1224,2K42X@204457,2U6AW@28211,COG1569@1,COG1569@2 NA|NA|NA S PIN domain MAG.T1.121_02642 42256.RradSPS_0358 1.6e-64 254.6 Rubrobacteria ko:K03556 ko00000,ko03000 Bacteria 2HENR@201174,4CPC9@84995,COG2909@1,COG2909@2 NA|NA|NA K helix_turn_helix, Lux Regulon MAG.T1.121_02643 370438.PTH_1536 7.1e-48 198.0 Peptococcaceae Bacteria 1TP7F@1239,247TZ@186801,263EU@186807,COG0303@1,COG0303@2 NA|NA|NA H Probable molybdopterin binding domain MAG.T1.121_02644 1038858.AXBA01000001_gene3490 3.5e-98 364.8 Xanthobacteraceae Bacteria 1MU3W@1224,2TT5X@28211,3EZUQ@335928,COG1028@1,COG1028@2 NA|NA|NA IQ KR domain MAG.T1.121_02645 1380346.JNIH01000001_gene4315 6.4e-14 85.1 Actinobacteria Bacteria 28MY8@1,2GMYY@201174,2ZB54@2 NA|NA|NA MAG.T1.121_02646 485913.Krac_6485 1.7e-25 122.9 Chloroflexi M1-431 Bacteria 2G9AR@200795,COG4283@1,COG4283@2 NA|NA|NA S Protein of unknown function (DUF1706) MAG.T1.121_02647 518766.Rmar_1581 5e-64 251.1 Bacteroidetes Order II. Incertae sedis Bacteria 1FJ4Y@1100069,4NGRW@976,COG0076@1,COG0076@2 NA|NA|NA E Pyridoxal-dependent decarboxylase conserved domain MAG.T1.121_02648 471853.Bcav_4191 3.8e-45 188.3 Bacteria Bacteria COG0673@1,COG0673@2 NA|NA|NA S inositol 2-dehydrogenase activity MAG.T1.121_02649 497964.CfE428DRAFT_3667 4.7e-45 188.3 Verrucomicrobia Bacteria 46UBG@74201,COG1082@1,COG1082@2 NA|NA|NA G Xylose isomerase-like TIM barrel MAG.T1.121_02650 526225.Gobs_2438 5.1e-27 128.6 Frankiales kdgK 2.7.1.45 ko:K00874 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00061,M00308,M00631 R01541 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 2GMD4@201174,4EV60@85013,COG0524@1,COG0524@2 NA|NA|NA G PFAM PfkB domain protein MAG.T1.121_02651 401526.TcarDRAFT_1329 3.6e-09 68.2 Negativicutes Bacteria 1U5QQ@1239,4H8CQ@909932,COG5611@1,COG5611@2 NA|NA|NA S PIN domain MAG.T1.121_02653 479434.Sthe_2532 4.1e-22 110.2 Bacteria chaB ko:K06197 ko00000 Bacteria COG4572@1,COG4572@2 NA|NA|NA MAG.T1.121_02654 1123242.JH636435_gene1284 3.8e-57 228.8 Planctomycetes 3.5.1.125 ko:K15784 ko00260,ko01100,map00260,map01100 R09801 RC00064,RC00300 ko00000,ko00001,ko01000 Bacteria 2IXSR@203682,COG3608@1,COG3608@2 NA|NA|NA S Succinylglutamate desuccinylase / Aspartoacylase family MAG.T1.121_02656 1156844.KB891851_gene4135 2.4e-34 152.5 Actinobacteria Bacteria 2DBMA@1,2I9ER@201174,2Z9Y3@2 NA|NA|NA S Domain of unknown function (DUF4389) MAG.T1.121_02657 324602.Caur_0147 2.8e-20 105.1 Chloroflexia yccF GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 2G74I@200795,375XJ@32061,COG3304@1,COG3304@2 NA|NA|NA S Inner membrane component domain MAG.T1.121_02658 309801.trd_A0613 1.1e-110 406.8 Thermomicrobia ko:K19689 ko00000,ko01000,ko01002 Bacteria 27YZB@189775,2G62B@200795,COG2309@1,COG2309@2 NA|NA|NA E Thermophilic metalloprotease (M29) MAG.T1.121_02659 1205910.B005_4066 5.4e-34 152.1 Streptosporangiales 2.7.1.219,2.7.1.220 ko:K22129 ko00000,ko01000 Bacteria 2GNIH@201174,4EPMA@85012,COG3395@1,COG3395@2 NA|NA|NA S Putative sugar-binding N-terminal domain MAG.T1.121_02660 35841.BT1A1_2898 6e-32 143.3 Bacillus pdxA 1.1.1.262,1.1.1.408,1.1.1.409 ko:K00097,ko:K22024 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQGT@1239,1ZCWV@1386,4HA7N@91061,COG1995@1,COG1995@2 NA|NA|NA H Belongs to the PdxA family MAG.T1.121_02661 479434.Sthe_1368 7.9e-13 81.3 Chloroflexi Bacteria 2DPD4@1,2G9MC@200795,331JQ@2 NA|NA|NA S Protein of unknown function (DUF3224) MAG.T1.121_02662 1128421.JAGA01000002_gene950 7.3e-13 79.7 Bacteria ymgE Bacteria COG2261@1,COG2261@2 NA|NA|NA S Transglycosylase associated protein MAG.T1.121_02663 1068980.ARVW01000001_gene6498 3.3e-89 335.9 Actinobacteria 2.7.13.3 ko:K02484,ko:K07768 ko02020,map02020 M00443 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 2I2DU@201174,COG5002@1,COG5002@2 NA|NA|NA T Histidine kinase MAG.T1.121_02664 1313172.YM304_31610 3.9e-72 278.1 Acidimicrobiia Bacteria 2GIZB@201174,4CMX9@84992,COG0745@1,COG0745@2 NA|NA|NA K Transcriptional regulatory protein, C terminal MAG.T1.121_02666 1382356.JQMP01000001_gene956 1.6e-25 123.2 Thermomicrobia Bacteria 27Z4A@189775,2G73S@200795,COG2353@1,COG2353@2 NA|NA|NA S YceI-like domain MAG.T1.121_02667 1382356.JQMP01000003_gene1940 3.2e-09 68.9 Thermomicrobia ko:K03642,ko:K19223 ko00000,ko01000,ko01002,ko01011 CBM50 Bacteria 27XPH@189775,2G99E@200795,COG0791@1,COG0791@2,COG3103@1,COG4991@2 NA|NA|NA MT NlpC/P60 family MAG.T1.121_02669 684949.ATTJ01000002_gene106 3.2e-17 95.1 Deinococcus-Thermus Bacteria 1WMG2@1297,2ECKJ@1,33KDJ@2 NA|NA|NA MAG.T1.121_02670 1382356.JQMP01000003_gene1554 2.9e-38 166.4 Thermomicrobia Bacteria 27Y14@189775,2G9NF@200795,COG0477@1,COG2814@2 NA|NA|NA EGP Major Facilitator Superfamily MAG.T1.121_02672 479434.Sthe_0182 1e-82 313.2 Chloroflexi Bacteria 2G88F@200795,COG0745@1,COG0745@2 NA|NA|NA K Two component transcriptional regulator, winged helix family MAG.T1.121_02673 479434.Sthe_1775 1.7e-81 309.3 Thermomicrobia tptC ko:K02003 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 27YCE@189775,2G6B5@200795,COG1136@1,COG1136@2 NA|NA|NA V ATPases associated with a variety of cellular activities MAG.T1.121_02674 479434.Sthe_1776 2.2e-193 682.9 Thermomicrobia ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 27Z42@189775,2G6CK@200795,COG0577@1,COG0577@2,COG3127@1,COG3127@2 NA|NA|NA V MacB-like periplasmic core domain MAG.T1.121_02676 485913.Krac_1224 9.4e-82 311.2 Chloroflexi Bacteria 2G6QM@200795,COG1680@1,COG1680@2 NA|NA|NA V COGs COG1680 Beta-lactamase class C and other penicillin binding protein MAG.T1.121_02677 28444.JODQ01000002_gene4038 3.6e-49 202.2 Streptosporangiales iunH2 3.2.2.1 ko:K01239 ko00230,ko00760,ko01100,map00230,map00760,map01100 R01245,R01273,R01677,R01770,R02143 RC00033,RC00063,RC00122,RC00318,RC00485 ko00000,ko00001,ko01000 Bacteria 2GP6N@201174,4EJEJ@85012,COG1957@1,COG1957@2 NA|NA|NA F Inosine-uridine preferring nucleoside hydrolase MAG.T1.121_02681 1382356.JQMP01000003_gene1403 3.3e-113 414.8 Thermomicrobia Bacteria 27XN4@189775,2DBIJ@1,2G896@200795,2Z9G2@2 NA|NA|NA S Phage capsid family MAG.T1.121_02683 479434.Sthe_0020 2.3e-122 446.0 Thermomicrobia Bacteria 27XP5@189775,28MN1@1,2G6CU@200795,2ZAXN@2 NA|NA|NA S Terminase-like family MAG.T1.121_02684 1382356.JQMP01000003_gene1400 4.6e-08 63.5 Thermomicrobia Bacteria 27ZCE@189775,2A4W8@1,2GBFW@200795,30THX@2 NA|NA|NA MAG.T1.121_02687 1112217.PPL19_06020 1.2e-26 125.9 Gammaproteobacteria phhB GO:0003674,GO:0003824,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008124,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019438,GO:0019751,GO:0034311,GO:0034312,GO:0034641,GO:0042558,GO:0042559,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 4.2.1.96 ko:K01724 ko00790,map00790 R04734 RC01208 ko00000,ko00001,ko01000,ko04147 Bacteria 1RH99@1224,1S5YX@1236,COG2154@1,COG2154@2 NA|NA|NA H pterin-4-alpha-carbinolamine dehydratase MAG.T1.121_02688 1095767.CAHD01000027_gene1649 2.1e-51 209.5 Cellulomonadaceae ko:K02026 M00207 ko00000,ko00002,ko02000 3.A.1.1 Bacteria 2GMTH@201174,4F1N6@85016,COG0395@1,COG0395@2 NA|NA|NA G Binding-protein-dependent transport system inner membrane component MAG.T1.121_02689 1089544.KB912942_gene4930 6.7e-48 198.0 Pseudonocardiales ko:K02025,ko:K10241,ko:K15771 ko02010,map02010 M00206,M00207,M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.2,3.A.1.1.23 Bacteria 2GKBJ@201174,4EEPX@85010,COG1175@1,COG1175@2 NA|NA|NA G Binding-protein-dependent transport system inner membrane component MAG.T1.121_02690 1232452.BAIB02000001_gene10 9.2e-27 128.3 Clostridia araN ko:K10188 ko02010,map02010 M00199 ko00000,ko00001,ko00002,ko02000 3.A.1.1.4 Bacteria 1TQ0V@1239,2481M@186801,COG1653@1,COG1653@2 NA|NA|NA G solute-binding protein MAG.T1.121_02691 485913.Krac_3868 3e-27 129.0 Bacteria ko:K05799 ko00000,ko03000 Bacteria COG2186@1,COG2186@2 NA|NA|NA K Transcriptional regulator MAG.T1.121_02692 479434.Sthe_3430 3e-110 405.6 Thermomicrobia Bacteria 27XFJ@189775,2G6QM@200795,COG1680@1,COG1680@2 NA|NA|NA V Beta-lactamase MAG.T1.121_02693 479434.Sthe_3430 5.8e-106 391.3 Thermomicrobia Bacteria 27XFJ@189775,2G6QM@200795,COG1680@1,COG1680@2 NA|NA|NA V Beta-lactamase MAG.T1.121_02694 479434.Sthe_3306 1.2e-217 762.7 Thermomicrobia ko:K06978 ko00000 Bacteria 27YZ6@189775,2GA38@200795,COG2936@1,COG2936@2 NA|NA|NA S X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain MAG.T1.121_02695 743718.Isova_2855 5.7e-33 148.3 Actinobacteria Bacteria 2DPQ5@1,2IQG8@201174,332Y1@2 NA|NA|NA MAG.T1.121_02697 485913.Krac_11341 8.9e-92 344.0 Chloroflexi dthadh 4.1.2.42,4.3.1.27 ko:K19967,ko:K20757 ko00000,ko01000 Bacteria 2G69D@200795,COG3616@1,COG3616@2 NA|NA|NA E PFAM alanine racemase domain protein MAG.T1.121_02698 1122138.AQUZ01000041_gene7242 3.5e-49 202.2 Propionibacteriales panE 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 Bacteria 2I3AM@201174,4DUY3@85009,COG1893@1,COG1893@2 NA|NA|NA H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid MAG.T1.121_02700 1038860.AXAP01000020_gene5600 1.7e-35 156.8 Bradyrhizobiaceae Bacteria 1PB22@1224,2U158@28211,3JUX7@41294,COG0697@1,COG0697@2 NA|NA|NA EG EamA-like transporter family MAG.T1.121_02702 953739.SVEN_6030 7.8e-64 251.1 Actinobacteria 3.4.16.4 ko:K01286 ko00000,ko01000 Bacteria 2GIX5@201174,COG1680@1,COG1680@2 NA|NA|NA V Beta-lactamase MAG.T1.121_02703 479434.Sthe_0384 3.7e-87 328.6 Thermomicrobia manC 2.7.7.13,5.3.1.8 ko:K00971,ko:K16011 ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025 M00114,M00361,M00362 R00885,R01819 RC00002,RC00376 ko00000,ko00001,ko00002,ko01000 Bacteria 27XWQ@189775,2G5WW@200795,COG0836@1,COG0836@2 NA|NA|NA M Mannose-6-phosphate isomerase MAG.T1.121_02704 1157490.EL26_14060 2.9e-39 168.7 Alicyclobacillaceae maf GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0030312,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0047429,GO:0071944 1.1.1.25,2.1.1.190 ko:K00014,ko:K03215,ko:K06287 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000,ko03009 Bacteria 1V6FH@1239,278G7@186823,4HIMK@91061,COG0424@1,COG0424@2 NA|NA|NA D Maf-like protein MAG.T1.121_02705 1123024.AUII01000015_gene3739 8.2e-17 93.6 Actinobacteria XK27_02315 Bacteria 2I3RY@201174,COG5646@1,COG5646@2 NA|NA|NA S Domain of unknown function (DU1801) MAG.T1.121_02706 1205680.CAKO01000038_gene1601 4.5e-100 372.1 Rhodospirillales Bacteria 1R4MM@1224,2JV5Z@204441,2U1JD@28211,COG0405@1,COG0405@2 NA|NA|NA E Gamma-glutamyltranspeptidase MAG.T1.121_02707 485913.Krac_3190 3.5e-24 119.4 Chloroflexi Bacteria 2G75J@200795,COG1063@1,COG1063@2 NA|NA|NA C PFAM Alcohol dehydrogenase zinc-binding domain protein MAG.T1.121_02708 344747.PM8797T_00629 1e-20 107.8 Planctomycetes Bacteria 2J1QN@203682,COG0673@1,COG0673@2 NA|NA|NA S Oxidoreductase family, C-terminal alpha/beta domain MAG.T1.121_02709 1394178.AWOO02000002_gene1762 2.6e-57 229.2 Actinobacteria Bacteria 2GN2G@201174,COG0179@1,COG0179@2 NA|NA|NA Q 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase MAG.T1.121_02710 1122223.KB890687_gene2828 9.1e-86 323.6 Bacteria appC ko:K02034 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria COG1173@1,COG1173@2 NA|NA|NA P ABC-type dipeptide oligopeptide nickel transport systems, permease components MAG.T1.121_02712 479434.Sthe_1677 1.1e-17 97.1 Thermomicrobia ko:K09017 ko00000,ko03000 Bacteria 27Z5B@189775,2G8XR@200795,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family MAG.T1.121_02713 1169154.KB897780_gene2120 3.7e-105 388.3 Actinobacteria drrA3 ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GIY8@201174,COG1131@1,COG1131@2 NA|NA|NA V ABC transporter MAG.T1.121_02714 656024.FsymDg_2182 1.5e-67 263.1 Frankiales ko:K01992,ko:K18233 ko02010,map02010 M00254,M00634 ko00000,ko00001,ko00002,ko01504,ko02000 3.A.1,3.A.1.105.2 Bacteria 2GKJF@201174,4ESJ2@85013,COG0842@1,COG0842@2 NA|NA|NA V Transport permease protein MAG.T1.121_02715 1380347.JNII01000005_gene3083 5.9e-33 147.5 Frankiales Bacteria 2IQV0@201174,4EWI7@85013,COG4803@1,COG4803@2 NA|NA|NA S Protein of unknown function (DUF1269) MAG.T1.121_02716 1283287.KB822583_gene2850 3.1e-75 288.5 Actinobacteria ygiF 3.6.1.25 ko:K18446 ko00000,ko01000 Bacteria 2IN8R@201174,COG3025@1,COG3025@2 NA|NA|NA S triphosphatase activity MAG.T1.121_02718 1303518.CCALI_00161 1.3e-78 299.7 Bacteria gip 5.3.1.22 ko:K01816 ko00630,ko01100,map00630,map01100 R01394 RC00511 ko00000,ko00001,ko01000 Bacteria COG3622@1,COG3622@2 NA|NA|NA G hydroxypyruvate isomerase activity MAG.T1.121_02719 1121377.KB906398_gene2411 2.6e-39 169.9 Deinococcus-Thermus Bacteria 1WK3B@1297,COG2133@1,COG2133@2 NA|NA|NA G pyrroloquinoline quinone binding MAG.T1.121_02720 1382306.JNIM01000001_gene1969 3.4e-53 215.3 Bacteria ada 2.1.1.63,3.2.2.21 ko:K00567,ko:K13529,ko:K15051 ko03410,map03410 ko00000,ko00001,ko01000,ko03000,ko03400 Bacteria COG0350@1,COG0350@2,COG2169@1,COG2169@2 NA|NA|NA K sequence-specific DNA binding MAG.T1.121_02721 1128421.JAGA01000002_gene1044 6.4e-14 83.6 Bacteria ko:K03088 ko00000,ko03021 Bacteria COG1595@1,COG1595@2 NA|NA|NA K DNA-templated transcription, initiation MAG.T1.121_02722 479434.Sthe_0097 1.3e-58 233.4 Thermomicrobia 1.8.5.2 ko:K15977,ko:K16937 ko00920,ko01120,map00920,map01120 R07177 ko00000,ko00001,ko01000 3.D.4.9 Bacteria 27Z4D@189775,2G6TC@200795,COG2259@1,COG2259@2 NA|NA|NA S DoxX MAG.T1.121_02723 266117.Rxyl_0446 2.6e-16 94.0 Rubrobacteria ydbT ko:K08981 ko00000 Bacteria 2GJCD@201174,4CQ5Y@84995,COG3428@1,COG3428@2 NA|NA|NA S Bacterial PH domain MAG.T1.121_02724 42256.RradSPS_2358 7.5e-07 60.8 Rubrobacteria ydbS ko:K09167 ko00000 Bacteria 2GSY6@201174,4CQQX@84995,COG3402@1,COG3402@2 NA|NA|NA S Bacterial PH domain MAG.T1.121_02725 344747.PM8797T_28729 1.7e-118 433.3 Planctomycetes 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 Bacteria 2IXW5@203682,COG0154@1,COG0154@2 NA|NA|NA J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) MAG.T1.121_02726 926550.CLDAP_15280 2.2e-59 237.3 Chloroflexi ydhQ GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716 2.7.11.1,3.4.21.102 ko:K03797,ko:K12132 ko00000,ko01000,ko01001,ko01002 Bacteria 2G7PQ@200795,COG0793@1,COG0793@2,COG3468@1,COG3468@2 NA|NA|NA M Peptidase family S41 MAG.T1.121_02727 1150864.MILUP08_42741 3.5e-102 379.0 Micromonosporales Bacteria 2GKQ2@201174,4D9R2@85008,COG1201@1,COG1201@2,COG1205@1,COG1205@2 NA|NA|NA L Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T1.121_02728 1094980.Mpsy_2844 3e-23 115.2 Methanomicrobia Archaea 2NA0P@224756,2XXKV@28890,arCOG03338@1,arCOG03338@2157 NA|NA|NA MAG.T1.121_02729 1123366.TH3_07547 9.9e-19 99.4 Alphaproteobacteria Bacteria 1NA48@1224,2UGHZ@28211,COG3093@1,COG3093@2 NA|NA|NA K Helix-turn-helix domain MAG.T1.121_02730 1121017.AUFG01000017_gene2488 6.6e-09 68.2 Intrasporangiaceae copC ko:K07156 ko00000,ko02000 9.B.62.2 Bacteria 2GMKG@201174,4FHQT@85021,COG2372@1,COG2372@2 NA|NA|NA S copper resistance protein MAG.T1.121_02731 1370125.AUWT01000029_gene735 2.1e-37 162.2 Mycobacteriaceae ko:K18828 ko00000,ko01000,ko02048,ko03016 Bacteria 23AGT@1762,2ID5E@201174,COG1487@1,COG1487@2 NA|NA|NA S Domain of unknown function (DUF4411) MAG.T1.121_02732 863365.XHC_1204 1.3e-98 366.7 Xanthomonadales Bacteria 1PFUN@1224,1RR40@1236,1X3AW@135614,COG2856@1,COG2856@2 NA|NA|NA E Pfam:DUF955 MAG.T1.121_02733 479434.Sthe_0671 4.4e-63 248.4 Thermomicrobia 3.5.2.6 ko:K17836 ko00311,ko01130,ko01501,map00311,map01130,map01501 M00627,M00628 R06363 RC01499 ko00000,ko00001,ko00002,ko01000,ko01504 Bacteria 27Z5G@189775,2GBEG@200795,COG2367@1,COG2367@2 NA|NA|NA V Beta-lactamase enzyme family MAG.T1.121_02738 264198.Reut_A1637 1.2e-143 516.5 Burkholderiaceae Bacteria 1KH5I@119060,1MUPW@1224,2VNG1@28216,COG0277@1,COG0277@2 NA|NA|NA C Berberine and berberine like MAG.T1.121_02739 479434.Sthe_2141 1.1e-165 590.9 Chloroflexi Bacteria 2GBNC@200795,COG2197@1,COG2197@2,COG3899@1,COG3899@2 NA|NA|NA K AAA ATPase domain MAG.T1.121_02740 358681.BBR47_13430 9.5e-60 237.3 Paenibacillaceae ko:K10119 ko02010,map02010 M00196 ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 Bacteria 1TR45@1239,26U5S@186822,4HCEH@91061,COG0395@1,COG0395@2 NA|NA|NA G Binding-protein-dependent transport system inner membrane component MAG.T1.121_02741 266117.Rxyl_0622 2e-44 186.4 Rubrobacteria yurN ko:K10118,ko:K15771,ko:K17238 ko02010,map02010 M00196,M00491,M00599 ko00000,ko00001,ko00002,ko02000 3.A.1.1.16,3.A.1.1.2,3.A.1.1.28,3.A.1.1.38 Bacteria 2GKJI@201174,4CT13@84995,COG1175@1,COG1175@2 NA|NA|NA P PFAM binding-protein-dependent transport systems inner membrane component MAG.T1.121_02742 526227.Mesil_2657 1.7e-08 66.6 Deinococcus-Thermus ko:K10117 ko02010,map02010 M00196 ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 Bacteria 1WJIF@1297,COG1653@1,COG1653@2 NA|NA|NA G ABC-type sugar transport system periplasmic component MAG.T1.121_02744 479434.Sthe_0651 9.9e-09 65.5 Thermomicrobia rpsU GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02970 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 27YPA@189775,2GB57@200795,COG0828@1,COG0828@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bS21 family MAG.T1.121_02745 204669.Acid345_2285 6e-45 188.0 Acidobacteriia Bacteria 2JK4T@204432,3Y3UW@57723,COG0491@1,COG0491@2 NA|NA|NA S Metallo-beta-lactamase superfamily MAG.T1.121_02747 203119.Cthe_2580 3.3e-27 128.6 Ruminococcaceae ysnB ko:K07095 ko00000 Bacteria 1V7VB@1239,257YU@186801,3WKCA@541000,COG0622@1,COG0622@2 NA|NA|NA S Calcineurin-like phosphoesterase superfamily domain MAG.T1.121_02748 479434.Sthe_0494 1.1e-107 396.7 Thermomicrobia dhsS 1.12.1.2 ko:K00436 R00700 ko00000,ko01000 iJN678.sll1559,iSB619.SA_RS08700 Bacteria 27Y2M@189775,2G5P3@200795,COG0075@1,COG0075@2 NA|NA|NA E Aminotransferase class-V MAG.T1.121_02749 479434.Sthe_0495 1.2e-162 579.7 Thermomicrobia ko:K02945 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 27XFV@189775,2G656@200795,COG0539@1,COG0539@2 NA|NA|NA J Ribosomal protein S1-like RNA-binding domain MAG.T1.121_02750 479434.Sthe_0496 1.8e-48 199.9 Thermomicrobia clpC GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0008150,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0040007,GO:0042802,GO:0042803,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0071944 ko:K03696 ko01100,map01100 ko00000,ko03110 Bacteria 27XGF@189775,2G5RA@200795,COG0542@1,COG0542@2 NA|NA|NA O Sigma-54 interaction domain MAG.T1.121_02751 909613.UO65_0305 1.6e-19 103.2 Bacteria Bacteria 2A5G6@1,30U67@2 NA|NA|NA MAG.T1.121_02753 314265.R2601_13514 7.2e-14 84.0 Alphaproteobacteria Bacteria 1RD7R@1224,2A5G6@1,2U8Y0@28211,30U67@2 NA|NA|NA MAG.T1.121_02754 479434.Sthe_0331 7.5e-20 103.6 Thermomicrobia yodM 3.1.3.2,3.1.3.27,3.1.3.4,3.1.3.81,3.6.1.27 ko:K01096,ko:K09474,ko:K19302 ko00550,ko00564,ko00740,ko01100,ko02020,map00550,map00564,map00740,map01100,map02020 R00548,R02029,R05627 RC00002,RC00017 ko00000,ko00001,ko01000,ko01011 Bacteria 27YK3@189775,2G8YH@200795,COG0671@1,COG0671@2 NA|NA|NA I Acid phosphatase homologues MAG.T1.121_02755 479434.Sthe_0332 4.6e-23 115.2 Thermomicrobia 3.1.4.46 ko:K01126 ko00564,map00564 R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 Bacteria 27YKV@189775,2GA1A@200795,COG0584@1,COG0584@2 NA|NA|NA C Glycerophosphoryl diester phosphodiesterase family MAG.T1.121_02756 479434.Sthe_0337 0.0 1377.8 Thermomicrobia ileS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iG2583_1286.G2583_0027,iPC815.YPO0475 Bacteria 27XEH@189775,2G5SN@200795,COG0060@1,COG0060@2 NA|NA|NA J Anticodon-binding domain of tRNA MAG.T1.121_02758 926569.ANT_16180 5.1e-64 251.5 Chloroflexi adoK GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004001,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005975,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019200,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032552,GO:0032553,GO:0032554,GO:0032555,GO:0032559,GO:0032560,GO:0032561,GO:0032567,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046390,GO:0046483,GO:0046835,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.15,2.7.1.20 ko:K00852,ko:K00856 ko00030,ko00230,ko01100,map00030,map00230,map01100 R00185,R01051,R02750 RC00002,RC00017 ko00000,ko00001,ko01000 iAF987.Gmet_2683 Bacteria 2G7YR@200795,COG0524@1,COG0524@2 NA|NA|NA G PFAM PfkB domain protein MAG.T1.121_02759 479434.Sthe_1121 2e-164 585.5 Thermomicrobia ahcY GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 Bacteria 27XWS@189775,2G5X8@200795,COG0499@1,COG0499@2 NA|NA|NA H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine MAG.T1.121_02760 406124.ACPC01000019_gene2897 1.3e-152 546.2 Bacillus metK GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPCV@1239,1ZBHR@1386,4HB33@91061,COG0192@1,COG0192@2 NA|NA|NA H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme MAG.T1.121_02762 1120917.AQXM01000062_gene1906 1.6e-59 236.9 Micrococcaceae mscS Bacteria 1W8C4@1268,2GJ51@201174,COG0668@1,COG0668@2 NA|NA|NA M Mechanosensitive ion channel MAG.T1.121_02763 1196031.ALEG01000072_gene962 1.1e-71 276.9 Bacillus dppC ko:K02034,ko:K13891,ko:K15582,ko:K16201 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00348,M00439,M00566 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.11,3.A.1.5.18,3.A.1.5.19,3.A.1.5.2,3.A.1.5.25 Bacteria 1TP4R@1239,1ZC1H@1386,4HBB9@91061,COG1173@1,COG1173@2 NA|NA|NA EP COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components MAG.T1.121_02764 604331.AUHY01000041_gene506 2.5e-79 302.4 Deinococcus-Thermus ko:K02033 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 1WMC0@1297,COG0601@1,COG0601@2 NA|NA|NA EP Binding-protein-dependent transport system inner membrane component MAG.T1.121_02765 604331.AUHY01000041_gene504 1.6e-86 327.0 Bacteria ko:K02035 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria COG0747@1,COG0747@2 NA|NA|NA E dipeptide transport MAG.T1.121_02766 926560.KE387023_gene2316 7.1e-86 324.7 Deinococcus-Thermus ko:K02035 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 1WM55@1297,COG0747@1,COG0747@2 NA|NA|NA E Bacterial extracellular solute-binding proteins, family 5 Middle MAG.T1.121_02767 1382356.JQMP01000003_gene1815 6.7e-67 261.2 Thermomicrobia 2.7.1.15,2.7.1.4,2.7.1.45 ko:K00847,ko:K00852,ko:K00874 ko00030,ko00051,ko00500,ko00520,ko01100,ko01120,ko01200,map00030,map00051,map00500,map00520,map01100,map01120,map01200 M00061,M00308,M00631 R00760,R00867,R01051,R01541,R02750,R03920 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 27XUV@189775,2G6PQ@200795,COG0524@1,COG0524@2 NA|NA|NA G pfkB family carbohydrate kinase MAG.T1.121_02768 479434.Sthe_0167 4.4e-64 251.5 Thermomicrobia jag ko:K06346,ko:K09749 ko00000 Bacteria 27XWI@189775,2G6XH@200795,COG1847@1,COG1847@2 NA|NA|NA S Putative single-stranded nucleic acids-binding domain MAG.T1.121_02769 479434.Sthe_0166 1.7e-77 296.6 Thermomicrobia yidC GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 Bacteria 27XWD@189775,2G6N0@200795,COG0706@1,COG0706@2 NA|NA|NA U PFAM 60 kDa inner membrane insertion protein MAG.T1.121_02770 1042376.AFPK01000039_gene1996 8.9e-20 102.4 unclassified Flavobacteriaceae yidD ko:K08998 ko00000 Bacteria 1I3W5@117743,406I0@61432,4NV1N@976,COG0759@1,COG0759@2 NA|NA|NA S Haemolytic domain MAG.T1.121_02771 479434.Sthe_0164 2.1e-12 78.6 Thermomicrobia rnpA GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031123,GO:0031404,GO:0031974,GO:0031981,GO:0032991,GO:0033204,GO:0034414,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042301,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043168,GO:0043170,GO:0043199,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043628,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901681,GO:1902494,GO:1902555,GO:1905267,GO:1905348,GO:1990904 3.1.26.5 ko:K03536,ko:K08998 ko00000,ko01000,ko03016 Bacteria 27YJ4@189775,2G76W@200795,COG0594@1,COG0594@2 NA|NA|NA J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme MAG.T1.121_02772 309801.trd_1088 1.6e-13 81.3 Thermomicrobia rpmH GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02914 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 27YQV@189775,2G7BX@200795,COG0230@1,COG0230@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL34 family MAG.T1.121_02776 1968.JOEV01000004_gene2902 7.1e-132 478.4 Actinobacteria 3.6.3.17 ko:K10441 ko02010,map02010 M00212 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 Bacteria 2GJ3F@201174,COG1129@1,COG1129@2 NA|NA|NA G Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system MAG.T1.121_02777 1120936.KB907212_gene5100 2.4e-61 242.7 Streptosporangiales ko:K10440 ko02010,map02010 M00212 ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 Bacteria 2GQDN@201174,4EJU7@85012,COG1172@1,COG1172@2 NA|NA|NA G Branched-chain amino acid transport system / permease component MAG.T1.121_02778 1219035.NT2_06_01990 7e-28 131.0 Alphaproteobacteria Bacteria 1RJ15@1224,2UCYU@28211,COG1432@1,COG1432@2 NA|NA|NA S NYN domain MAG.T1.121_02779 525368.HMPREF0591_4328 1.4e-164 586.3 Actinobacteria Bacteria 2GP9F@201174,COG0308@1,COG0308@2 NA|NA|NA E Phospholipase B MAG.T1.121_02780 469371.Tbis_3555 5.5e-78 297.7 Pseudonocardiales glnQ 3.6.3.21 ko:K02028 M00236 ko00000,ko00002,ko01000,ko02000 3.A.1.3 Bacteria 2GIZW@201174,4E109@85010,COG1126@1,COG1126@2 NA|NA|NA E AAA domain, putative AbiEii toxin, Type IV TA system MAG.T1.121_02781 76636.JOEC01000001_gene939 1.4e-87 329.7 Microbacteriaceae ko:K02029 M00236 ko00000,ko00002,ko02000 3.A.1.3 Bacteria 2GM0I@201174,4FN8V@85023,COG0765@1,COG0765@2 NA|NA|NA E Binding-protein-dependent transport system inner membrane component MAG.T1.121_02783 1499967.BAYZ01000193_gene3921 3.5e-78 298.5 unclassified Bacteria ubiA Bacteria 2NNVJ@2323,COG0382@1,COG0382@2 NA|NA|NA H UbiA prenyltransferase family MAG.T1.121_02784 1340493.JNIF01000003_gene4350 2.6e-26 124.8 Acidobacteria ko:K04749 ko00000,ko03021 Bacteria 3Y4U6@57723,COG1366@1,COG1366@2 NA|NA|NA T Belongs to the anti-sigma-factor antagonist family MAG.T1.121_02785 1304883.KI912532_gene917 0.0 1471.1 Rhodocyclales glpCD 1.1.2.4,1.97.1.9 ko:K00102,ko:K12527 ko00450,ko00620,map00450,map00620 R00197,R07229 RC00044,RC02420 ko00000,ko00001,ko01000 Bacteria 1MU43@1224,2KUWB@206389,2VHYU@28216,COG0247@1,COG0247@2,COG0277@1,COG0277@2,COG0479@1,COG0479@2 NA|NA|NA C FAD linked oxidase MAG.T1.121_02786 522306.CAP2UW1_0262 4.3e-209 734.2 unclassified Betaproteobacteria ilvA GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 iJN678.ilvA Bacteria 1KPQ0@119066,1MVWJ@1224,2VI5U@28216,COG1171@1,COG1171@2 NA|NA|NA E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA MAG.T1.121_02788 159087.Daro_4131 5.7e-25 120.9 Rhodocyclales ygfA GO:0003674,GO:0003824,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019752,GO:0022611,GO:0030272,GO:0032502,GO:0034641,GO:0035999,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.2 ko:K01934 ko00670,ko01100,map00670,map01100 R02301 RC00183 ko00000,ko00001,ko01000 iECABU_c1320.ECABU_c31940,iECOK1_1307.ECOK1_3298,iECSF_1327.ECSF_2705,iUTI89_1310.UTI89_C3298 Bacteria 1MZG0@1224,2KWQ6@206389,2VJZE@28216,COG0212@1,COG0212@2 NA|NA|NA H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family MAG.T1.121_02789 1121017.AUFG01000001_gene3109 2.2e-83 317.0 Intrasporangiaceae cphA 6.3.2.13,6.3.2.29,6.3.2.30 ko:K01928,ko:K03802 ko00300,ko00550,map00300,map00550 R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 Bacteria 2GN0U@201174,4FESF@85021,COG0189@1,COG0189@2,COG0769@1,COG0769@2 NA|NA|NA HJM Belongs to the MurCDEF family MAG.T1.121_02791 479434.Sthe_3149 3.4e-139 501.5 Bacteria 1.7.2.1 ko:K00368 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 Bacteria COG2132@1,COG2132@2 NA|NA|NA Q Multicopper oxidase MAG.T1.121_02792 479434.Sthe_3148 3.4e-121 441.8 Chloroflexi ko:K07238 ko00000,ko02000 2.A.5.5 Bacteria 2G9IR@200795,COG0428@1,COG0428@2 NA|NA|NA P transporter MAG.T1.121_02794 309801.trd_A0730 4.6e-21 108.6 Thermomicrobia 3.1.31.1 ko:K01174 ko00000,ko01000 Bacteria 27YTT@189775,2GBHE@200795,COG1525@1,COG1525@2 NA|NA|NA L nuclease MAG.T1.121_02796 1172186.KB911475_gene4062 9.6e-113 413.3 Mycobacteriaceae Bacteria 23AUA@1762,2IIR3@201174,COG4725@1,COG4725@2 NA|NA|NA KT MT-A70 MAG.T1.121_02797 653386.HMPREF0975_02238 2e-60 239.2 Actinobacteria Bacteria 28J7N@1,2IBUF@201174,2Z931@2,4D6S3@85005 NA|NA|NA L Restriction endonuclease BglII MAG.T1.121_02798 479434.Sthe_3071 8.5e-80 303.9 Thermomicrobia Bacteria 27Y7R@189775,2G8CA@200795,COG2141@1,COG2141@2 NA|NA|NA C Luciferase-like monooxygenase MAG.T1.121_02799 928724.SacglDRAFT_02023 1.3e-86 326.6 Bacteria ko:K07045 ko00000 Bacteria COG2159@1,COG2159@2 NA|NA|NA E amidohydrolase MAG.T1.121_02800 406124.ACPC01000019_gene2901 2.3e-97 362.8 Bacillus ko:K02027 M00207 ko00000,ko00002,ko02000 3.A.1.1 Bacteria 1TRIH@1239,1ZEWW@1386,4HBRS@91061,COG1653@1,COG1653@2 NA|NA|NA G Bacterial extracellular solute-binding protein MAG.T1.121_02801 1007103.AFHW01000135_gene6419 4.3e-81 308.1 Paenibacillaceae ko:K02025,ko:K15771 ko02010,map02010 M00207,M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.2 Bacteria 1V06M@1239,274SS@186822,4HAXH@91061,COG1175@1,COG1175@2 NA|NA|NA G Binding-protein-dependent transport system inner membrane component MAG.T1.121_02802 1122222.AXWR01000066_gene2661 3.2e-95 355.1 Deinococcus-Thermus lacG ko:K02026 M00207 ko00000,ko00002,ko02000 3.A.1.1 Bacteria 1WIW4@1297,COG0395@1,COG0395@2 NA|NA|NA G Binding-protein-dependent transport system inner membrane component MAG.T1.121_02803 479434.Sthe_2980 4.5e-11 75.1 Thermomicrobia Bacteria 27YD3@189775,2GBNJ@200795,COG3881@1,COG3881@2 NA|NA|NA S PRC-barrel domain MAG.T1.121_02804 1122132.AQYH01000005_gene748 7.1e-160 570.5 Rhizobiaceae tpa 2.6.1.77 ko:K03851 ko00430,ko01100,map00430,map01100 R05652 RC00008,RC00062 ko00000,ko00001,ko01000,ko01007 Bacteria 1MU2N@1224,2TQND@28211,4BCEY@82115,COG0161@1,COG0161@2 NA|NA|NA H Aminotransferase class-III MAG.T1.121_02805 765420.OSCT_2281 6.3e-67 262.7 Chloroflexia Bacteria 2G7Q4@200795,3754G@32061,COG2909@1,COG2909@2 NA|NA|NA K ATP-dependent transcriptional regulator, MalT-like, LuxR family MAG.T1.121_02806 42256.RradSPS_2356 1.3e-44 188.0 Bacteria ko:K03546 ko00000,ko03400 Bacteria COG0419@1,COG0419@2 NA|NA|NA L ATPase involved in DNA repair MAG.T1.121_02807 479434.Sthe_2300 4.8e-72 277.3 Thermomicrobia dcd GO:0003674,GO:0003824,GO:0004170,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006244,GO:0006253,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008829,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009166,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009223,GO:0009262,GO:0009264,GO:0009314,GO:0009394,GO:0009628,GO:0009987,GO:0015949,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0033973,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046065,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0050896,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.5.4.13 ko:K01494 ko00240,ko01100,map00240,map01100 M00053 R00568,R02325 RC00074 ko00000,ko00001,ko00002,ko01000 iPC815.YPO1525 Bacteria 27XS2@189775,2G7HJ@200795,COG0717@1,COG0717@2 NA|NA|NA F Belongs to the dCTP deaminase family MAG.T1.121_02808 479434.Sthe_2337 5.1e-21 107.5 Thermomicrobia Bacteria 27YKY@189775,2A4R7@1,2GBB1@200795,30TCK@2 NA|NA|NA MAG.T1.121_02809 1128421.JAGA01000002_gene96 1.2e-47 196.1 unclassified Bacteria ndk GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 Bacteria 2NPM5@2323,COG0105@1,COG0105@2 NA|NA|NA F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate MAG.T1.121_02813 1321781.HMPREF1985_00993 6.7e-07 62.0 Negativicutes Bacteria 1V1W3@1239,2ENE7@1,33G1P@2,4H40J@909932 NA|NA|NA MAG.T1.121_02815 479434.Sthe_2353 2.7e-29 135.6 Chloroflexi adsA ko:K03088 ko00000,ko03021 Bacteria 2G6X7@200795,COG1595@1,COG1595@2 NA|NA|NA K TIGRFAM RNA polymerase sigma factor, sigma-70 family MAG.T1.121_02816 47763.JNZA01000012_gene6487 7.7e-85 321.2 Actinobacteria Bacteria 2GNST@201174,COG1073@1,COG1073@2 NA|NA|NA S Belongs to the UPF0255 family MAG.T1.121_02817 489825.LYNGBM3L_36300 1.5e-14 87.0 Oscillatoriales cpdA Bacteria 1G1J1@1117,1H7NH@1150,COG1409@1,COG1409@2 NA|NA|NA S PFAM Calcineurin-like phosphoesterase MAG.T1.121_02818 1519464.HY22_13950 1.6e-28 132.9 Bacteria Bacteria COG4636@1,COG4636@2 NA|NA|NA D protein conserved in cyanobacteria MAG.T1.121_02819 1453501.JELR01000001_gene1801 1.7e-126 459.1 Gammaproteobacteria 3.5.1.24 ko:K01442 ko00120,ko00121,ko01100,map00120,map00121,map01100 R02797,R03975,R03977,R04486,R04487,R05835 RC00090,RC00096 ko00000,ko00001,ko01000 Bacteria 1MWPQ@1224,1RN43@1236,COG3049@1,COG3049@2 NA|NA|NA M Choloylglycine hydrolase MAG.T1.121_02820 1453501.JELR01000001_gene1801 1.5e-106 392.9 Gammaproteobacteria 3.5.1.24 ko:K01442 ko00120,ko00121,ko01100,map00120,map00121,map01100 R02797,R03975,R03977,R04486,R04487,R05835 RC00090,RC00096 ko00000,ko00001,ko01000 Bacteria 1MWPQ@1224,1RN43@1236,COG3049@1,COG3049@2 NA|NA|NA M Choloylglycine hydrolase MAG.T1.121_02823 1144343.PMI41_03169 1.9e-26 125.6 Alphaproteobacteria ko:K07064 ko00000 Bacteria 1MZR2@1224,2USTA@28211,COG1848@1,COG1848@2 NA|NA|NA S Toxic component of a toxin-antitoxin (TA) module. An RNase MAG.T1.121_02824 1042326.AZNV01000004_gene4029 2.4e-15 89.4 Rhizobiaceae Bacteria 1R469@1224,2U4KR@28211,4BCYP@82115,COG1814@1,COG1814@2 NA|NA|NA S VIT family MAG.T1.121_02825 357808.RoseRS_2408 2.2e-22 113.2 Chloroflexia corA ko:K03284 ko00000,ko02000 1.A.35.1,1.A.35.3 Bacteria 2G6EQ@200795,375MB@32061,COG0598@1,COG0598@2 NA|NA|NA P Mediates influx of magnesium ions MAG.T1.121_02826 1382356.JQMP01000004_gene619 4.4e-11 76.3 Thermomicrobia Bacteria 27XS0@189775,2G8SG@200795,COG0477@1,COG2814@2 NA|NA|NA EGP Transmembrane secretion effector MAG.T1.121_02827 479431.Namu_4034 1.6e-19 102.1 Bacteria Bacteria 29JYD@1,33FMY@2 NA|NA|NA MAG.T1.121_02828 1288484.APCS01000001_gene630 2.9e-07 63.2 Deinococcus-Thermus Bacteria 1WMVW@1297,2EAFX@1,334J9@2 NA|NA|NA MAG.T1.121_02829 1449058.JQKT01000008_gene2627 4.7e-07 62.8 Microbacteriaceae Bacteria 2GMKX@201174,4FMXY@85023,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily MAG.T1.121_02830 945713.IALB_2901 6.3e-54 218.0 Bacteria menC GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 4.2.1.113 ko:K02549 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R04031 RC01053 ko00000,ko00001,ko00002,ko01000 Bacteria COG4948@1,COG4948@2 NA|NA|NA M carboxylic acid catabolic process MAG.T1.121_02833 745776.DGo_CA0723 4.9e-18 98.6 Bacteria MA20_31645 Bacteria COG4315@1,COG4315@2 NA|NA|NA P Pfam Secreted repeat of MAG.T1.121_02834 243231.GSU0574 5.7e-49 201.4 Desulfuromonadales ko:K03298 ko00000,ko02000 2.A.7.3 Bacteria 1MUQ7@1224,2WMRT@28221,42R74@68525,43VWE@69541,COG0697@1,COG0697@2 NA|NA|NA EG EamA-like transporter family MAG.T1.121_02835 485913.Krac_5322 5.2e-54 217.6 Bacteria Bacteria COG2320@1,COG2320@2 NA|NA|NA Q Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A MAG.T1.121_02837 765698.Mesci_2924 3.4e-60 238.4 Phyllobacteriaceae Bacteria 1NEKW@1224,2U0MC@28211,43J4M@69277,COG1733@1,COG1733@2 NA|NA|NA K HxlR-like helix-turn-helix MAG.T1.121_02838 1382356.JQMP01000001_gene733 2.4e-17 96.7 Thermomicrobia mprF GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.3.2.3 ko:K07027,ko:K14205 ko01503,ko02020,ko05150,map01503,map02020,map05150 M00726 ko00000,ko00001,ko00002,ko01000,ko01504,ko02000 2.A.1.3.37,4.D.2 iYO844.BG12900 Bacteria 27YNQ@189775,2G6KJ@200795,COG0392@1,COG0392@2,COG2898@1,COG2898@2 NA|NA|NA S Uncharacterised conserved protein (DUF2156) MAG.T1.121_02839 1382356.JQMP01000001_gene733 2.2e-29 136.7 Thermomicrobia mprF GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.3.2.3 ko:K07027,ko:K14205 ko01503,ko02020,ko05150,map01503,map02020,map05150 M00726 ko00000,ko00001,ko00002,ko01000,ko01504,ko02000 2.A.1.3.37,4.D.2 iYO844.BG12900 Bacteria 27YNQ@189775,2G6KJ@200795,COG0392@1,COG0392@2,COG2898@1,COG2898@2 NA|NA|NA S Uncharacterised conserved protein (DUF2156) MAG.T1.121_02840 479434.Sthe_1793 1.8e-122 446.0 Chloroflexi frc_4 2.8.3.22 ko:K18289 ko00660,map00660 R02407,R03154 RC00014 ko00000,ko00001,ko01000 Bacteria 2G61Y@200795,COG1804@1,COG1804@2 NA|NA|NA C PFAM L-carnitine dehydratase bile acid-inducible protein F MAG.T1.121_02842 1121382.JQKG01000022_gene1422 1.6e-28 133.3 Bacteria Bacteria COG0639@1,COG0639@2 NA|NA|NA T phosphoprotein phosphatase activity MAG.T1.121_02843 1123388.AQWU01000073_gene1109 1.4e-25 124.0 Deinococcus-Thermus 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 Bacteria 1WI6K@1297,COG3375@1,COG3375@2 NA|NA|NA M carboxylic acid catabolic process MAG.T1.121_02848 42256.RradSPS_2352 1.3e-23 117.5 Bacteria ko:K09785 ko00000 Bacteria COG2380@1,COG2380@2 NA|NA|NA NU COGs COG2380 conserved MAG.T1.121_02849 266117.Rxyl_0452 1.9e-167 596.3 Actinobacteria Bacteria 2I0H5@201174,COG0433@1,COG0433@2 NA|NA|NA S COG0433 Predicted ATPase MAG.T1.121_02850 42256.RradSPS_2355 1.2e-49 204.1 Bacteria 3.1.1.53 ko:K03547,ko:K05970 ko00000,ko01000,ko03400 Bacteria COG0420@1,COG0420@2 NA|NA|NA L 3'-5' exonuclease activity MAG.T1.121_02853 1297863.APJF01000026_gene3675 1.7e-78 299.3 Bradyrhizobiaceae 1.16.3.3 ko:K22348 ko00000,ko01000 Bacteria 1MU0J@1224,2TUTX@28211,3JWBZ@41294,COG2132@1,COG2132@2 NA|NA|NA Q Domain of unknown function (DUF4396) MAG.T1.121_02854 1173020.Cha6605_5457 4.6e-44 185.7 Bacteria Bacteria COG2133@1,COG2133@2 NA|NA|NA G pyrroloquinoline quinone binding MAG.T1.121_02855 688269.Theth_0468 7.7e-66 257.7 Thermotogae 3.2.1.81 ko:K01219,ko:K21000 ko02025,map02025 ko00000,ko00001,ko01000 GH39 Bacteria 2GDXZ@200918,COG1874@1,COG1874@2 NA|NA|NA G Beta-galactosidase MAG.T1.121_02856 357808.RoseRS_1413 3e-24 118.6 Chloroflexia Bacteria 2G90F@200795,377N7@32061,COG4636@1,COG4636@2 NA|NA|NA S Putative restriction endonuclease MAG.T1.121_02857 266117.Rxyl_0534 1.6e-29 135.6 Rubrobacteria 1.7.1.15 ko:K00363 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 Bacteria 2IFRC@201174,4CQUM@84995,COG2146@1,COG2146@2 NA|NA|NA P Rieske [2Fe-2S] domain MAG.T1.121_02858 266117.Rxyl_0533 3.8e-108 398.3 Rubrobacteria ko:K07045 ko00000 Bacteria 2GNF3@201174,4CQMN@84995,COG2159@1,COG2159@2 NA|NA|NA S Amidohydrolase MAG.T1.121_02859 1123057.P872_24300 1.3e-15 88.6 Cytophagia Bacteria 47QAB@768503,4NPF9@976,COG0251@1,COG0251@2 NA|NA|NA J translation initiation inhibitor, yjgF family MAG.T1.121_02860 479434.Sthe_0169 7.7e-45 187.2 Chloroflexi mnmE GO:0003674,GO:0005488,GO:0005515,GO:0042802 ko:K03650 R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 Bacteria 2G647@200795,COG0486@1,COG0486@2 NA|NA|NA J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 MAG.T1.121_02862 926569.ANT_25950 5e-20 104.4 Bacteria Bacteria COG0454@1,COG0456@2 NA|NA|NA K acetyltransferase MAG.T1.121_02863 1121877.JQKF01000001_gene1300 1.6e-12 79.3 Acidimicrobiia Bacteria 2E3FZ@1,2HGRD@201174,31FAR@2,4CNTW@84992 NA|NA|NA MAG.T1.121_02864 1121373.KB903624_gene2427 4e-34 151.0 Cytophagia ysfE 4.4.1.5 ko:K01759 ko00620,map00620 R02530 RC00004,RC00740 ko00000,ko00001,ko01000 Bacteria 47RRJ@768503,4NQAI@976,COG0346@1,COG0346@2 NA|NA|NA E Glyoxalase-like domain MAG.T1.121_02865 571166.KI421509_gene2039 1.1e-56 226.9 Alphaproteobacteria Bacteria 1R79J@1224,2U421@28211,COG0500@1,COG2226@2 NA|NA|NA Q ubiE/COQ5 methyltransferase family MAG.T1.121_02866 479434.Sthe_3319 9.1e-18 98.2 Bacteria blaB 3.5.2.6 ko:K17836 ko00311,ko01130,ko01501,map00311,map01130,map01501 M00627,M00628 R06363 RC01499 ko00000,ko00001,ko00002,ko01000,ko01504 Bacteria COG2367@1,COG2367@2 NA|NA|NA V Beta-lactamase MAG.T1.121_02867 479434.Sthe_3319 1.1e-20 107.8 Bacteria blaB 3.5.2.6 ko:K17836 ko00311,ko01130,ko01501,map00311,map01130,map01501 M00627,M00628 R06363 RC01499 ko00000,ko00001,ko00002,ko01000,ko01504 Bacteria COG2367@1,COG2367@2 NA|NA|NA V Beta-lactamase MAG.T1.121_02870 1382356.JQMP01000001_gene1112 8.9e-15 87.8 Thermomicrobia Bacteria 27Z6N@189775,2GBEQ@200795,COG4454@1,COG4454@2 NA|NA|NA MAG.T1.121_02871 937777.Deipe_2474 5.6e-09 68.6 Bacteria Bacteria COG4454@1,COG4454@2 NA|NA|NA MAG.T1.121_02872 485913.Krac_6991 6e-105 388.7 Chloroflexi Bacteria 2G88D@200795,COG4585@1,COG4585@2 NA|NA|NA T histidine kinase, dimerisation and phosphoacceptor region MAG.T1.121_02873 1146883.BLASA_1056 4e-68 264.6 Actinobacteria Bacteria 2GKBX@201174,COG2197@1,COG2197@2 NA|NA|NA T response regulator, receiver MAG.T1.121_02874 1437882.AZRU01000045_gene4758 9.9e-11 73.9 Pseudomonas aeruginosa group ko:K03556 ko00000,ko03000 Bacteria 1MVZZ@1224,1RN29@1236,1YD9Z@136841,COG2909@1,COG2909@2 NA|NA|NA K AAA ATPase domain MAG.T1.121_02876 479434.Sthe_1929 7e-14 86.3 Bacteria ko:K03641 ko00000,ko02000 2.C.1.2 Bacteria COG0823@1,COG0823@2 NA|NA|NA U Involved in the tonB-independent uptake of proteins MAG.T1.121_02877 309801.trd_A0640 1.6e-21 109.8 Thermomicrobia ylcC 3.4.22.70 ko:K07284 ko00000,ko01000,ko01002,ko01011 Bacteria 27YHD@189775,2G77W@200795,COG3764@1,COG3764@2 NA|NA|NA M peptidase C60 sortase A and B MAG.T1.121_02880 1122132.AQYH01000008_gene2638 2e-185 655.6 Rhizobiaceae 1.1.1.400 ko:K20927 ko00000,ko01000 Bacteria 1MU3F@1224,2TT3C@28211,4BMJE@82115,COG2303@1,COG2303@2 NA|NA|NA E GMC oxidoreductase MAG.T1.121_02881 1382356.JQMP01000003_gene1500 1.9e-37 162.5 Thermomicrobia ko:K03088 ko00000,ko03021 Bacteria 27Z8H@189775,2G6UE@200795,COG1595@1,COG1595@2 NA|NA|NA K ECF sigma factor MAG.T1.121_02882 1121378.KB899732_gene4318 6.8e-28 130.6 Bacteria Bacteria COG1846@1,COG1846@2 NA|NA|NA K DNA-binding transcription factor activity MAG.T1.121_02883 684949.ATTJ01000004_gene3539 4.3e-30 137.5 Bacteria Bacteria COG1917@1,COG1917@2 NA|NA|NA L Cupin 2, conserved barrel domain protein MAG.T1.121_02885 926550.CLDAP_18080 2.8e-96 359.0 Chloroflexi Bacteria 2G62S@200795,COG2133@1,COG2133@2 NA|NA|NA G Glucose / Sorbosone dehydrogenase MAG.T1.121_02886 1382356.JQMP01000001_gene1054 9e-59 233.8 Thermomicrobia Bacteria 27YY5@189775,2G6SC@200795,COG1028@1,COG1028@2 NA|NA|NA IQ KR domain MAG.T1.121_02887 522306.CAP2UW1_2031 2.4e-77 295.4 unclassified Betaproteobacteria Bacteria 1KQQ9@119066,1MWUX@1224,2VIUF@28216,COG0076@1,COG0076@2 NA|NA|NA E Pyridoxal-dependent decarboxylase conserved domain MAG.T1.121_02888 1123386.AUIW01000001_gene314 7.4e-33 146.7 Deinococcus-Thermus ko:K07065 ko00000 Bacteria 1WJXR@1297,COG2402@1,COG2402@2 NA|NA|NA S Toxic component of a toxin-antitoxin (TA) module. An RNase MAG.T1.121_02891 477641.MODMU_1166 4.5e-96 359.4 Frankiales Bacteria 2GIZ1@201174,4EUW7@85013,COG1813@1,COG1813@2,COG3903@1,COG3903@2 NA|NA|NA K Helix-turn-helix domain MAG.T1.121_02892 101510.RHA1_ro03050 3.7e-100 371.7 Nocardiaceae Bacteria 2GM7J@201174,4G8K2@85025,COG0673@1,COG0673@2 NA|NA|NA S oxidoreductase MAG.T1.121_02893 525904.Tter_1807 3.2e-42 179.1 Bacteria Bacteria COG1082@1,COG1082@2 NA|NA|NA G myo-inosose-2 dehydratase activity MAG.T1.121_02894 479434.Sthe_1716 6.9e-170 603.6 Thermomicrobia ino1 GO:0003674,GO:0003824,GO:0004512,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009405,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016853,GO:0016872,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659 5.5.1.4 ko:K01858 ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130 R07324 RC01804 ko00000,ko00001,ko01000 Bacteria 27Y0U@189775,2G5YH@200795,COG1260@1,COG1260@2 NA|NA|NA I Myo-inositol-1-phosphate synthase MAG.T1.121_02895 66692.ABC3097 1.9e-20 107.5 Bacillus atl 3.2.1.96,3.4.17.14,3.5.1.28,6.1.1.12 ko:K01227,ko:K01876,ko:K07260,ko:K11060,ko:K13714,ko:K21472 ko00511,ko00550,ko00970,ko01100,ko01502,ko02020,map00511,map00550,map00970,map01100,map01502,map02020 M00359,M00360,M00651 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01002,ko01007,ko01011,ko01504,ko02042,ko03016,ko03029 GH73 Bacteria 1UI28@1239,1ZC2V@1386,4ISBN@91061,COG3103@1,COG3103@2,COG3807@1,COG3807@2,COG4193@1,COG4193@2 NA|NA|NA G Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase MAG.T1.121_02897 47839.CCAU010000011_gene5579 3.7e-60 238.8 Mycobacteriaceae repC ko:K18996 ko00000,ko03032 Bacteria 2337H@1762,2I3CC@201174,COG1414@1,COG1414@2 NA|NA|NA K PFAM O-methyltransferase MAG.T1.121_02899 1408254.T458_04940 1e-31 144.1 Paenibacillaceae Bacteria 1VUUB@1239,26RQC@186822,4HVMJ@91061,COG1215@1,COG1215@2 NA|NA|NA M Glycosyl Transferase MAG.T1.121_02901 445961.IW15_01805 3.2e-22 111.7 Chryseobacterium Bacteria 1I3M4@117743,3ZRPU@59732,4NQHR@976,COG4430@1,COG4430@2 NA|NA|NA S Domain of unknown function (DUF1905) MAG.T1.121_02902 882086.SacxiDRAFT_4078 1.4e-23 117.5 Pseudonocardiales Bacteria 2H012@201174,4DYIA@85010,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily MAG.T1.121_02903 565653.EGBG_02856 7.5e-12 78.6 Enterococcaceae lytG ko:K02395,ko:K14196,ko:K19220 ko05150,map05150 ko00000,ko00001,ko01000,ko01002,ko01011,ko02035 Bacteria 1UYRM@1239,4AZE2@81852,4HAU6@91061,COG1388@1,COG1388@2,COG1705@1,COG1705@2,COG3103@1,COG4991@2 NA|NA|NA MNU defense response to other organism MAG.T1.121_02904 1123073.KB899242_gene1594 2.4e-25 121.7 Xanthomonadales Bacteria 1MZMZ@1224,1S9ZW@1236,1X7QK@135614,COG5478@1,COG5478@2 NA|NA|NA S Low affinity iron permease MAG.T1.121_02905 926550.CLDAP_25070 7.2e-27 127.9 Chloroflexi hemD GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107,2.5.1.61,4.2.1.75 ko:K01719,ko:K01749,ko:K13542,ko:K13543 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084,R03165,R03194 RC00003,RC00871,RC01861,RC02317 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS15755,iJN678.hemD Bacteria 2G70F@200795,COG1587@1,COG1587@2 NA|NA|NA H PFAM Uroporphyrinogen III synthase HEM4 MAG.T1.121_02906 232721.Ajs_1889 2.8e-124 451.8 Comamonadaceae adhA 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 Bacteria 1MUTT@1224,2VMBM@28216,4ACH4@80864,COG1064@1,COG1064@2 NA|NA|NA C Alcohol dehydrogenase GroES domain protein MAG.T1.121_02907 1218352.B597_014065 8.9e-20 102.8 Pseudomonas stutzeri group adhA 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 Bacteria 1MUTT@1224,1RPQC@1236,1Z0NP@136846,COG1064@1,COG1064@2 NA|NA|NA S COG1064 Zn-dependent alcohol dehydrogenases MAG.T1.121_02908 479434.Sthe_0152 2.4e-134 485.3 Thermomicrobia 1.16.3.3,1.7.2.1 ko:K00368,ko:K22348 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 Bacteria 27YH6@189775,2G8IH@200795,COG2132@1,COG2132@2 NA|NA|NA Q Multicopper oxidase MAG.T1.121_02910 697282.Mettu_0152 7e-65 253.8 Methylococcales yrrM 2.1.1.104 ko:K00588 ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110 M00039,M00350 R01942,R06578 RC00003,RC00392 ko00000,ko00001,ko00002,ko01000 Bacteria 1RB34@1224,1S02F@1236,1XEH3@135618,COG4122@1,COG4122@2 NA|NA|NA S O-methyltransferase MAG.T1.121_02911 525904.Tter_1977 5.3e-121 440.7 unclassified Bacteria Bacteria 2NQXW@2323,COG2141@1,COG2141@2 NA|NA|NA C Luciferase-like monooxygenase MAG.T1.121_02912 1122939.ATUD01000003_gene3528 1e-61 243.8 Actinobacteria 1.13.11.2 ko:K07104 ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220 M00569 R00816,R04089,R05295,R05404,R05406,R07795 RC00387,RC00643,RC01075,RC01364,RC01914 ko00000,ko00001,ko00002,ko01000 Bacteria 2GN1X@201174,COG2514@1,COG2514@2 NA|NA|NA S glyoxalase bleomycin resistance protein dioxygenase MAG.T1.121_02913 40571.JOEA01000028_gene5484 4e-115 421.8 Pseudonocardiales ko:K02027,ko:K10117 ko02010,map02010 M00196,M00207 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.28 Bacteria 2GP9H@201174,4E21A@85010,COG1653@1,COG1653@2 NA|NA|NA G Bacterial extracellular solute-binding protein MAG.T1.121_02914 1121382.JQKG01000005_gene3294 1.4e-230 805.8 Deinococcus-Thermus bgaB 3.2.1.23 ko:K12308 ko00052,map00052 R01105 RC00452 ko00000,ko00001,ko01000 Bacteria 1WJAT@1297,COG1874@1,COG1874@2 NA|NA|NA G Beta-galactosidase trimerisation domain MAG.T1.121_02916 1121939.L861_17285 9.1e-45 187.2 Gammaproteobacteria Bacteria 1MUPW@1224,1RRDD@1236,COG0277@1,COG0277@2 NA|NA|NA C FAD linked oxidase domain protein MAG.T1.121_02918 936455.KI421499_gene1781 9.4e-217 760.0 Bradyrhizobiaceae minD GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 ko:K07100 ko00000 Bacteria 1RAG8@1224,2U5HS@28211,3JZK6@41294,COG1926@1,COG1926@2,COG2312@1,COG2312@2 NA|NA|NA S Phosphoribosyl transferase domain MAG.T1.121_02919 926569.ANT_10740 6.8e-173 614.4 Chloroflexi ko:K07114 ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 Bacteria 2G7VX@200795,COG2304@1,COG2304@2 NA|NA|NA S VWA domain containing CoxE-like protein MAG.T1.121_02921 649638.Trad_0966 3.6e-44 184.1 Bacteria Bacteria COG3795@1,COG3795@2 NA|NA|NA F YCII-related domain MAG.T1.121_02922 1211815.CBYP010000021_gene3217 4.1e-41 173.7 Frankiales uvrA2 Bacteria 2GJUV@201174,4EU81@85013,COG0178@1,COG0178@2 NA|NA|NA L ABC transporter MAG.T1.121_02923 1405498.SSIM_03305 9.9e-08 66.2 Staphylococcaceae sdrF 3.1.1.3 ko:K01046,ko:K14192,ko:K14194 ko00561,ko01100,ko05150,map00561,map01100,map05150 M00098 R02250,R02687 RC00020,RC00037,RC00041,RC00094 ko00000,ko00001,ko00002,ko01000 Bacteria 1UWPZ@1239,4H0IS@90964,4I2G0@91061,COG3087@1,COG3087@2,COG4932@1,COG4932@2 NA|NA|NA M SdrD B-like domain MAG.T1.121_02924 485913.Krac_5158 5.6e-21 107.1 Bacteria Bacteria COG0662@1,COG0662@2 NA|NA|NA G Cupin 2, conserved barrel domain protein MAG.T1.121_02925 316274.Haur_3631 1.9e-69 269.2 Chloroflexia ko:K21006 ko02025,map02025 ko00000,ko00001 Bacteria 2G7U5@200795,3775X@32061,COG3868@1,COG3868@2 NA|NA|NA S Glycoside-hydrolase family GH114 MAG.T1.121_02926 309801.trd_1080 3.4e-170 604.7 Thermomicrobia 2.6.1.113 ko:K12256 ko00330,ko01100,map00330,map01100 R08714 RC00008,RC00062 ko00000,ko00001,ko01000,ko01007 Bacteria 27XJ0@189775,2G62N@200795,COG0161@1,COG0161@2 NA|NA|NA H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family MAG.T1.121_02927 1177594.MIC448_1220001 1.2e-32 147.5 Bacteria MA20_40210 ko:K02051 M00188 ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 Bacteria COG0715@1,COG0715@2 NA|NA|NA P thiamine-containing compound biosynthetic process MAG.T1.121_02928 1231185.BAMP01000005_gene3991 3.9e-34 152.5 Phyllobacteriaceae MA20_40210 ko:K02051 M00188 ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 Bacteria 1MVJA@1224,2TTB8@28211,43IRY@69277,COG0715@1,COG0715@2 NA|NA|NA P ABC-type nitrate sulfonate bicarbonate transport MAG.T1.121_02929 1121924.ATWH01000014_gene3385 3.5e-70 271.6 Actinobacteria Bacteria 2H979@201174,COG0684@1,COG0684@2 NA|NA|NA H Aldolase/RraA MAG.T1.121_02930 479434.Sthe_0463 2.3e-154 552.0 Thermomicrobia ispG GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009055,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0022900,GO:0030312,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044464,GO:0046429,GO:0046490,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0052592,GO:0055114,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS06430,iJN678.gcpE Bacteria 27XZE@189775,2G5SC@200795,COG0821@1,COG0821@2 NA|NA|NA I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate MAG.T1.121_02931 479434.Sthe_0464 1.8e-101 376.3 Thermomicrobia rseP GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016021,GO:0016787,GO:0019219,GO:0019222,GO:0019538,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0040007,GO:0043170,GO:0043856,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0045152,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:0140110,GO:1901564,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 3.4.21.107 ko:K04771,ko:K11749,ko:K16922 ko01503,ko02020,ko02024,ko04112,map01503,map02020,map02024,map04112 M00728 ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 Bacteria 27XS5@189775,2G6HV@200795,COG0750@1,COG0750@2 NA|NA|NA M Domain present in PSD-95, Dlg, and ZO-1/2. MAG.T1.121_02933 1128421.JAGA01000001_gene2400 3.4e-71 275.4 Bacteria Bacteria COG0739@1,COG0739@2 NA|NA|NA M heme binding MAG.T1.121_02934 292459.STH496 4.2e-32 144.4 Clostridia Bacteria 1VHQV@1239,24SJS@186801,COG1051@1,COG1051@2 NA|NA|NA F NUDIX domain MAG.T1.121_02936 479434.Sthe_3165 1.4e-31 142.5 Thermomicrobia Bacteria 27YD0@189775,29I5S@1,2GB9P@200795,3052X@2 NA|NA|NA MAG.T1.121_02937 525904.Tter_1235 1.2e-41 177.6 unclassified Bacteria yueF GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 ko:K03548 ko00000,ko02000 2.A.86.1 Bacteria 2NPIB@2323,COG0628@1,COG0628@2 NA|NA|NA S AI-2E family transporter MAG.T1.121_02938 485913.Krac_5292 1.2e-35 156.4 Bacteria coaE 2.7.1.24 ko:K00859 ko00770,ko01100,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 Bacteria COG0237@1,COG0237@2 NA|NA|NA H dephospho-CoA kinase activity MAG.T1.121_02944 1382356.JQMP01000003_gene1773 3.9e-71 275.4 Thermomicrobia 3.5.2.6 ko:K01467 ko01501,ko02020,map01501,map02020 M00628 R06363 RC01499 ko00000,ko00001,ko00002,ko01000 Bacteria 27YYY@189775,2GBDK@200795,COG1680@1,COG1680@2 NA|NA|NA V Beta-lactamase MAG.T1.121_02945 1382356.JQMP01000003_gene1773 3.4e-64 252.3 Thermomicrobia 3.5.2.6 ko:K01467 ko01501,ko02020,map01501,map02020 M00628 R06363 RC01499 ko00000,ko00001,ko00002,ko01000 Bacteria 27YYY@189775,2GBDK@200795,COG1680@1,COG1680@2 NA|NA|NA V Beta-lactamase MAG.T1.121_02946 1123401.JHYQ01000043_gene762 1.7e-16 91.7 Bacteria Bacteria COG2161@1,COG2161@2 NA|NA|NA D toxin-antitoxin pair type II binding MAG.T1.121_02947 1123401.JHYQ01000043_gene761 6.6e-25 120.2 Bacteria vapC ko:K07062 ko00000,ko01000,ko02048 Bacteria COG1487@1,COG1487@2 NA|NA|NA S nuclease activity MAG.T1.121_02950 1183438.GKIL_1936 1e-55 225.3 Cyanobacteria Bacteria 1G5W7@1117,COG3629@1,COG3629@2,COG3903@1,COG3903@2 NA|NA|NA K Bacterial transcriptional activator domain MAG.T1.121_02952 420662.Mpe_A1469 4.7e-40 170.6 unclassified Burkholderiales aat GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008914,GO:0016740,GO:0016746,GO:0016755,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.3.2.6 ko:K00684 R03813,R11443,R11444 RC00055,RC00064 ko00000,ko01000 Bacteria 1KJE1@119065,1R9W8@1224,2VIUV@28216,COG2360@1,COG2360@2 NA|NA|NA O Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine MAG.T1.121_02953 420662.Mpe_A1468 5.9e-116 423.7 unclassified Burkholderiales ate GO:0003674,GO:0003824,GO:0004057,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016598,GO:0016740,GO:0016746,GO:0016755,GO:0019538,GO:0019941,GO:0030163,GO:0036211,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575 2.3.2.29 ko:K21420 R11547,R11548 RC00064 ko00000,ko01000 Bacteria 1KK3Z@119065,1MW62@1224,2VJ8E@28216,COG2935@1,COG2935@2 NA|NA|NA O May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate MAG.T1.121_02954 666681.M301_2470 2.8e-73 282.3 Nitrosomonadales rpfF ko:K13816 ko02020,ko02024,map02020,map02024 ko00000,ko00001 Bacteria 1MUD7@1224,2KMQ7@206350,2VQ37@28216,COG1024@1,COG1024@2 NA|NA|NA I Enoyl-CoA hydratase/isomerase MAG.T1.121_02955 1095769.CAHF01000022_gene39 1.4e-117 430.6 Oxalobacteraceae 2.7.13.3 ko:K10715 ko02020,ko02024,map02020,map02024 M00517 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 1R5EN@1224,2WGK9@28216,47913@75682,COG5002@1,COG5002@2 NA|NA|NA T Histidine Phosphotransfer domain MAG.T1.121_02956 861299.J421_0530 2.9e-40 172.6 Bacteria Bacteria COG4757@1,COG4757@2 NA|NA|NA S Serine aminopeptidase, S33 MAG.T1.121_02959 479434.Sthe_3330 1.3e-111 409.8 Thermomicrobia cel 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 R06200,R11307,R11308 ko00000,ko00001,ko01000 GH5,GH9 Bacteria 27Y0M@189775,2G6EE@200795,COG1363@1,COG1363@2 NA|NA|NA G M42 glutamyl aminopeptidase MAG.T1.121_02962 309801.trd_0443 1.5e-139 502.7 Thermomicrobia clpB GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 ko:K03694,ko:K03695 ko04213,map04213 ko00000,ko00001,ko03110 Bacteria 27XEJ@189775,2G5QU@200795,COG0542@1,COG0542@2 NA|NA|NA O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE MAG.T1.121_02963 926550.CLDAP_18720 6.4e-164 583.6 Chloroflexi Bacteria 2G67Q@200795,COG4030@1,COG4030@2 NA|NA|NA S Protein of unknown function (DUF2961) MAG.T1.121_02965 479434.Sthe_2353 7.6e-34 150.6 Chloroflexi adsA ko:K03088 ko00000,ko03021 Bacteria 2G6X7@200795,COG1595@1,COG1595@2 NA|NA|NA K TIGRFAM RNA polymerase sigma factor, sigma-70 family MAG.T1.121_02968 525904.Tter_0302 6.5e-16 91.7 unclassified Bacteria Bacteria 2NR68@2323,COG1432@1,COG1432@2 NA|NA|NA S NYN domain MAG.T1.121_02969 251221.35214577 4.1e-109 402.1 Bacteria mutS ko:K03555 ko03430,map03430 ko00000,ko00001,ko03400 Bacteria COG0249@1,COG0249@2 NA|NA|NA L mismatched DNA binding MAG.T1.121_02970 693977.Deipr_0183 3.3e-19 101.7 Bacteria ko:K09004 ko00000 Bacteria COG1416@1,COG1416@2 NA|NA|NA MAG.T1.121_02971 1382356.JQMP01000003_gene1830 5.2e-142 511.1 Thermomicrobia Bacteria 27XWR@189775,2G62C@200795,COG0624@1,COG0624@2 NA|NA|NA E peptidase M20 MAG.T1.121_02972 479434.Sthe_0410 2.1e-12 78.2 Thermomicrobia yggT GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02221 ko00000,ko02044 Bacteria 27YQI@189775,2G9QH@200795,COG0762@1,COG0762@2 NA|NA|NA S YGGT family MAG.T1.121_02973 1031711.RSPO_c01637 7e-11 74.3 Burkholderiaceae Bacteria 1K2SM@119060,1N0H3@1224,2VQEB@28216,COG0517@1,COG0517@2 NA|NA|NA C CBS domain containing protein MAG.T1.121_02975 1120948.KB903229_gene5064 1.3e-25 124.0 Pseudonocardiales Bacteria 2DBVK@1,2H5Z5@201174,2ZBBH@2,4E6UF@85010 NA|NA|NA MAG.T1.121_02976 1463901.JOIY01000005_gene1829 2.2e-67 262.7 Actinobacteria ureD ko:K03190 ko00000 Bacteria 2HHBD@201174,COG0829@1,COG0829@2 NA|NA|NA O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter MAG.T1.121_02977 1041522.MCOL_V224247 3.3e-71 275.0 Actinobacteria ureG ko:K03189,ko:K04652 ko00000,ko03110 Bacteria 2GNUV@201174,COG0378@1,COG0378@2 NA|NA|NA KO Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG MAG.T1.121_02978 452652.KSE_63570 9.6e-50 203.8 Kitasatospora ureF ko:K03188 ko00000 Bacteria 2I9VS@201174,2M2MV@2063,COG0830@1,COG0830@2 NA|NA|NA O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter MAG.T1.121_02979 1121952.ATXT01000011_gene2566 1.6e-97 362.5 Microbacteriaceae ureC 3.5.1.5 ko:K01427,ko:K01428 ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120 R00131 RC02798,RC02806 ko00000,ko00001,ko01000 Bacteria 2GM7X@201174,4FQWH@85023,COG0804@1,COG0804@2 NA|NA|NA E Urease alpha-subunit, N-terminal domain MAG.T1.121_02980 479434.Sthe_0263 9.7e-50 204.9 Bacteria ko:K02035 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria COG0747@1,COG0747@2 NA|NA|NA E dipeptide transport MAG.T1.121_02981 469383.Cwoe_2768 6.6e-34 151.0 Bacteria csiR GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 ko:K15735 ko00000,ko03000 Bacteria COG1802@1,COG1802@2 NA|NA|NA K Transcriptional regulator MAG.T1.121_02982 1033743.CAES01000046_gene268 1.8e-50 206.5 Bacilli 3.1.2.32 ko:K20257 ko00405,ko01130,ko02024,ko02025,map00405,map01130,map02024,map02025 R11542 RC00014 ko00000,ko00001,ko01000 Bacteria 1V4VK@1239,4I071@91061,COG0491@1,COG0491@2 NA|NA|NA S Metallo-beta-lactamase superfamily MAG.T1.121_02983 1123023.JIAI01000007_gene1829 4.1e-41 174.5 Bacteria pdxH ko:K07005 ko00000 Bacteria COG3467@1,COG3467@2 NA|NA|NA T pyridoxamine 5'-phosphate MAG.T1.121_02989 479434.Sthe_2671 1e-97 363.6 Thermomicrobia ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 27Y6R@189775,2G7V6@200795,COG1131@1,COG1131@2 NA|NA|NA V AAA domain, putative AbiEii toxin, Type IV TA system MAG.T1.121_02990 479434.Sthe_2670 1.8e-78 299.7 Chloroflexi ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2G6II@200795,COG0842@1,COG0842@2 NA|NA|NA V PFAM ABC-2 type transporter MAG.T1.121_02994 749927.AMED_5391 6e-28 131.7 Pseudonocardiales ko:K20541 ko00000,ko02000 4.D.3.1.6 Bacteria 2GMBB@201174,4E3ST@85010,COG3170@1,COG3170@2,COG3209@1,COG3209@2 NA|NA|NA M RHS Repeat MAG.T1.121_02996 749927.AMED_5391 2.1e-23 117.5 Pseudonocardiales ko:K20541 ko00000,ko02000 4.D.3.1.6 Bacteria 2GMBB@201174,4E3ST@85010,COG3170@1,COG3170@2,COG3209@1,COG3209@2 NA|NA|NA M RHS Repeat MAG.T1.121_02998 1352941.M877_13810 1.5e-17 97.1 Actinobacteria Bacteria 2GMBB@201174,COG3209@1,COG3209@2 NA|NA|NA M COG3209 Rhs family protein MAG.T1.121_02999 1002340.AFCF01000058_gene4212 5.8e-17 96.7 Alphaproteobacteria ko:K07126 ko00000 Bacteria 1MXFD@1224,2TRW5@28211,COG0790@1,COG0790@2,COG4249@1,COG4249@2 NA|NA|NA L Peptidase C14 caspase catalytic subunit p20 MAG.T1.121_03000 479434.Sthe_2353 9.9e-24 117.1 Chloroflexi adsA ko:K03088 ko00000,ko03021 Bacteria 2G6X7@200795,COG1595@1,COG1595@2 NA|NA|NA K TIGRFAM RNA polymerase sigma factor, sigma-70 family MAG.T1.121_03003 309801.trd_0041 2.8e-76 292.0 Thermomicrobia crt 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 R03026 RC00831 ko00000,ko00001,ko01000 Bacteria 27XKS@189775,2G5JW@200795,COG1024@1,COG1024@2 NA|NA|NA I Belongs to the enoyl-CoA hydratase isomerase family MAG.T1.121_03004 553204.CORAM0001_0492 1.3e-29 136.3 Corynebacteriaceae gca Bacteria 22MWU@1653,2GP22@201174,COG0663@1,COG0663@2 NA|NA|NA S Carbonic anhydrases acetyltransferases, isoleucine patch superfamily MAG.T1.121_03005 525904.Tter_0363 2.1e-123 449.1 unclassified Bacteria mmgA GO:0003674,GO:0003824,GO:0003988,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 iYO844.BSU24170 Bacteria 2NNU9@2323,COG0183@1,COG0183@2 NA|NA|NA I Belongs to the thiolase family MAG.T1.121_03006 479434.Sthe_0821 2.7e-182 644.8 Thermomicrobia B4168_2380 1.3.99.32 ko:K16173 ko00362,ko01120,map00362,map01120 R05579 RC00052 ko00000,ko00001,ko01000 Bacteria 27Y45@189775,2G65J@200795,COG1960@1,COG1960@2 NA|NA|NA C Acyl- CoA dehydrogenase type 2 domain MAG.T1.121_03007 1123023.JIAI01000026_gene4343 8.3e-55 220.3 Bacteria kynB GO:0003674,GO:0003824,GO:0004061,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019439,GO:0019441,GO:0019752,GO:0032787,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043167,GO:0043169,GO:0043420,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0070189,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.1.1.363,1.1.1.49,3.5.1.9 ko:K00036,ko:K07130 ko00030,ko00380,ko00480,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00380,map00480,map00630,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008,M00038 R00835,R00988,R01959,R02736,R04911,R10907 RC00001,RC00066,RC00263,RC00323 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria COG1878@1,COG1878@2 NA|NA|NA S arylformamidase activity MAG.T1.121_03008 479434.Sthe_3356 2.7e-127 462.2 Thermomicrobia ytfL GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03699 ko00000,ko02042 Bacteria 27Z1M@189775,2G6D1@200795,COG1253@1,COG1253@2 NA|NA|NA P Transporter associated domain MAG.T1.121_03009 479434.Sthe_3156 3.3e-98 365.2 Thermomicrobia troA GO:0005575,GO:0005623,GO:0042597,GO:0044464 ko:K11707 ko02010,map02010 M00319 ko00000,ko00001,ko00002,ko02000 3.A.1.15 Bacteria 27XHP@189775,2G8F6@200795,COG0803@1,COG0803@2 NA|NA|NA P Belongs to the bacterial solute-binding protein 9 family MAG.T1.121_03010 479434.Sthe_3155 8.8e-102 376.7 Thermomicrobia mntB ko:K09820,ko:K11710 ko02010,map02010 M00243,M00319 ko00000,ko00001,ko00002,ko02000 3.A.1.15 iYO844.BSU30760 Bacteria 27XH6@189775,2G7X2@200795,COG1121@1,COG1121@2 NA|NA|NA P ATPases associated with a variety of cellular activities MAG.T1.121_03013 1155714.KB891993_gene5470 2.1e-63 249.2 Actinobacteria hmuV 1.14.15.20,3.6.3.33,3.6.3.34 ko:K02013,ko:K06074,ko:K21480 ko00860,ko01100,ko01110,ko02010,map00860,map01100,map01110,map02010 M00240,M00241 R11579 RC01270 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.13,3.A.1.14 Bacteria 2GMUI@201174,COG4559@1,COG4559@2 NA|NA|NA P Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system MAG.T1.121_03014 1382356.JQMP01000001_gene1040 6.3e-95 354.4 Thermomicrobia hmuU ko:K02015 ko02010,map02010 M00240 ko00000,ko00001,ko00002,ko02000 3.A.1.14 Bacteria 27Z8M@189775,2GAPB@200795,COG0609@1,COG0609@2 NA|NA|NA P FecCD transport family MAG.T1.121_03015 1382356.JQMP01000001_gene1039 3.6e-71 275.4 Chloroflexi hmuT ko:K02016 ko02010,map02010 M00240 ko00000,ko00001,ko00002,ko02000 3.A.1.14 Bacteria 2GA8E@200795,COG4558@1,COG4558@2 NA|NA|NA P PFAM periplasmic binding protein MAG.T1.121_03018 1192034.CAP_3735 0.0 1128.2 Myxococcales 3.4.21.10 ko:K01317 ko00000,ko01000,ko01002,ko04131 Bacteria 1QX45@1224,2WTP9@28221,2YWVC@29,42YA1@68525,COG1572@1,COG1572@2 NA|NA|NA M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane MAG.T1.121_03019 1254432.SCE1572_35365 2.7e-27 129.0 Myxococcales ko:K03832 ko00000,ko02000 2.C.1.1 Bacteria 1R65W@1224,2WT3A@28221,2YYW2@29,42XJ0@68525,COG0810@1,COG0810@2 NA|NA|NA M Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins MAG.T1.121_03022 246196.MSMEI_3630 3.1e-18 97.1 Mycobacteriaceae Bacteria 233Z6@1762,2GW8A@201174,COG1028@1,COG1028@2 NA|NA|NA IQ Enoyl-(Acyl carrier protein) reductase MAG.T1.121_03023 290317.Cpha266_0896 3.5e-25 120.9 Bacteria hsdR_2 3.1.21.3 ko:K01153 ko00000,ko01000,ko02048 Bacteria COG4096@1,COG4096@2 NA|NA|NA L type I site-specific deoxyribonuclease activity MAG.T1.121_03024 1239962.C943_03350 1.8e-89 335.9 Cytophagia Bacteria 28HAW@1,2Z7N4@2,47TIM@768503,4NG29@976 NA|NA|NA S KilA-N MAG.T1.121_03025 290317.Cpha266_0895 2.6e-15 87.8 Bacteria 2.1.1.72,3.1.21.3 ko:K01154,ko:K03427 ko00000,ko01000,ko02048 Bacteria COG0286@1,COG0286@2,COG0732@1,COG0732@2 NA|NA|NA V type I restriction modification DNA specificity domain MAG.T1.121_03026 1205910.B005_3041 1e-36 160.6 Streptosporangiales Bacteria 2GMGR@201174,4EIJQ@85012,COG3544@1,COG3544@2 NA|NA|NA S Domain of unknown function (DUF305) MAG.T1.121_03027 479434.Sthe_3269 2.1e-92 345.9 Thermomicrobia zitB GO:0000041,GO:0003674,GO:0005215,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008150,GO:0008324,GO:0015075,GO:0015318,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0044464,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662 ko:K16264 ko00000,ko02000 2.A.4.1 iNRG857_1313.NRG857_03325,iPC815.YPO1129 Bacteria 27XHG@189775,2G6FI@200795,COG1230@1,COG1230@2 NA|NA|NA P Cation efflux family MAG.T1.121_03028 1510531.JQJJ01000012_gene1524 1.2e-100 372.9 Bradyrhizobiaceae ywjA ko:K06147 ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 1MUBM@1224,2TQMR@28211,3JSJZ@41294,COG1132@1,COG1132@2 NA|NA|NA V ABC transporter transmembrane region MAG.T1.121_03030 469383.Cwoe_4139 3.7e-45 188.3 Rubrobacteria yjjM GO:0005975,GO:0006082,GO:0006355,GO:0008150,GO:0008152,GO:0009056,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016052,GO:0016054,GO:0019219,GO:0019222,GO:0019520,GO:0019583,GO:0019584,GO:0019752,GO:0031323,GO:0031326,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046395,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0072329,GO:0080090,GO:1901575,GO:1903506,GO:2000112,GO:2001141 Bacteria 2HGS9@201174,4CTKK@84995,COG1802@1,COG1802@2 NA|NA|NA K regulatory protein GntR HTH MAG.T1.121_03031 469383.Cwoe_4138 1.2e-122 446.4 Rubrobacteria Bacteria 2ID60@201174,4CTIG@84995,COG2141@1,COG2141@2 NA|NA|NA C Luciferase-like monooxygenase MAG.T1.121_03032 580332.Slit_2521 1.2e-24 119.4 Nitrosomonadales 2.6.1.102 ko:K13010 ko00520,map00520 R10460 RC00006,RC00781 ko00000,ko00001,ko01000,ko01005,ko01007 Bacteria 1N0QW@1224,2VVHG@28216,44WG8@713636,COG0399@1,COG0399@2 NA|NA|NA J 23S rRNA-intervening sequence protein MAG.T1.121_03033 469383.Cwoe_4137 5e-118 431.0 Bacteria ko:K19689 ko00000,ko01000,ko01002 Bacteria COG2309@1,COG2309@2 NA|NA|NA E aminopeptidase activity MAG.T1.121_03035 215803.DB30_1184 1.8e-26 125.9 Myxococcales Bacteria 1P2JD@1224,2E2SC@1,2WYVJ@28221,2Z0QX@29,32XUP@2,434IA@68525 NA|NA|NA S Allene oxide cyclase MAG.T1.121_03036 1172180.KB911795_gene7747 2e-17 95.5 Actinobacteria Bacteria 2E7SB@1,2GRIZ@201174,3327J@2 NA|NA|NA S Domain of unknown function (DUF4260) MAG.T1.121_03037 1476876.JOJO01000014_gene7212 7.4e-36 157.1 Actinobacteria Bacteria 2IMC6@201174,COG1309@1,COG1309@2 NA|NA|NA K PFAM regulatory protein TetR MAG.T1.121_03038 1521187.JPIM01000062_gene2434 1.2e-232 813.1 Chloroflexia lon 3.4.21.53 ko:K01338 ko04112,map04112 ko00000,ko00001,ko01000,ko01002 Bacteria 2G5TZ@200795,374W9@32061,COG0466@1,COG0466@2 NA|NA|NA O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner MAG.T1.121_03040 1121035.AUCH01000002_gene1707 4.6e-58 230.7 Rhodocyclales nuoE 1.6.5.3,1.6.99.3 ko:K00334,ko:K03943 ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016 M00143,M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1,3.D.1.6 Bacteria 1MWS2@1224,2KUI7@206389,2VQD9@28216,COG1905@1,COG1905@2 NA|NA|NA C COG1905 NADH ubiquinone oxidoreductase 24 kD subunit MAG.T1.121_03041 1304883.KI912532_gene20 1.2e-214 752.3 Rhodocyclales nuoD GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00333,ko:K13378 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 1MVIN@1224,2KUP4@206389,2VHEC@28216,COG0649@1,COG0649@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient MAG.T1.121_03042 395019.Bmul_1030 1.5e-72 279.3 Burkholderiaceae nuoC GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 1K15D@119060,1MX4B@1224,2VHHV@28216,COG0852@1,COG0852@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient MAG.T1.121_03043 159087.Daro_0950 2.5e-83 314.7 Rhodocyclales nuoB GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 1MUI2@1224,2KVKP@206389,2VIWK@28216,COG0377@1,COG0377@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient MAG.T1.121_03044 1266925.JHVX01000013_gene1671 8.4e-44 183.0 Nitrosomonadales nuoA GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044464,GO:0050136,GO:0055114,GO:0071944,GO:0098796,GO:1902494 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 1RGUT@1224,2VSI3@28216,3737D@32003,COG0838@1,COG0838@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient MAG.T1.121_03046 743719.PaelaDRAFT_4659 1e-15 90.5 Paenibacillaceae Bacteria 1U12I@1239,272V6@186822,4IAIP@91061,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family MAG.T1.121_03047 266940.Krad_2686 7.9e-13 80.9 Actinobacteria Bacteria 2IDS1@201174,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family MAG.T1.121_03048 266940.Krad_2686 2.2e-15 89.4 Actinobacteria Bacteria 2IDS1@201174,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family MAG.T1.121_03049 485913.Krac_7358 1.6e-191 676.0 Chloroflexi bglC 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 GH3 Bacteria 2G84T@200795,COG1472@1,COG1472@2 NA|NA|NA G PFAM glycoside hydrolase, family 3 domain protein MAG.T1.121_03050 331869.BAL199_30142 7.1e-30 136.7 Alphaproteobacteria purN 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 Bacteria 1RGZ3@1224,2U95Z@28211,COG3801@1,COG3801@2 NA|NA|NA S YjbR MAG.T1.121_03052 1380350.JIAP01000019_gene21 9.8e-104 383.6 Proteobacteria ko:K02058,ko:K10439 ko02010,ko02030,map02010,map02030 M00212,M00221 ko00000,ko00001,ko00002,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 Bacteria 1R5UE@1224,COG1879@1,COG1879@2 NA|NA|NA G Periplasmic binding protein domain MAG.T1.121_03053 1266925.JHVX01000002_gene781 6e-238 830.5 Nitrosomonadales tkt 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUEY@1224,2VJEM@28216,372NW@32003,COG0021@1,COG0021@2 NA|NA|NA G Transketolase, thiamine diphosphate binding domain MAG.T1.121_03054 1121033.AUCF01000002_gene597 2.2e-29 134.8 Rhodospirillales cas2 ko:K09951 ko00000,ko02048 Bacteria 1NDNR@1224,2JTT5@204441,2UBT6@28211,COG3512@1,COG3512@2 NA|NA|NA L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette MAG.T1.121_03055 596153.Alide_0206 1.9e-84 319.3 Comamonadaceae cas1 ko:K15342 ko00000,ko02048,ko03400 Bacteria 1MX9W@1224,2VNWK@28216,4ACAR@80864,COG1518@1,COG1518@2 NA|NA|NA L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette MAG.T1.121_03056 83406.HDN1F_34120 9.5e-172 610.9 Proteobacteria cas9 ko:K09952 ko00000,ko01000,ko02048 Bacteria 1MVT9@1224,COG3513@1,COG3513@2 NA|NA|NA L CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer MAG.T1.121_03060 479434.Sthe_0685 7e-20 104.0 Thermomicrobia mec 3.13.1.6 ko:K21140 ko04122,map04122 R11524 RC00064,RC00090 ko00000,ko00001,ko01000 Bacteria 27YR1@189775,2G7CC@200795,COG1310@1,COG1310@2 NA|NA|NA S JAB/MPN domain MAG.T1.121_03061 479434.Sthe_0683 4.9e-31 141.0 Chloroflexi 3.8.1.2 ko:K01560,ko:K07025 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 R05287 RC00697 ko00000,ko00001,ko01000 Bacteria 2G74Q@200795,COG1011@1,COG1011@2 NA|NA|NA S DinB superfamily MAG.T1.121_03066 1957.JODX01000016_gene1997 2.8e-91 342.0 Actinobacteria ngcG ko:K10202 ko02010,map02010 M00205 ko00000,ko00001,ko00002,ko02000 3.A.1.1.18 Bacteria 2GNQW@201174,COG0395@1,COG0395@2 NA|NA|NA G Binding-protein-dependent transport systems inner membrane component MAG.T1.121_03067 1121946.AUAX01000004_gene774 9e-79 300.4 Micromonosporales ko:K10201,ko:K15771 ko02010,map02010 M00205,M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1.16,3.A.1.1.18,3.A.1.1.2 Bacteria 2GJZD@201174,4DBF0@85008,COG1175@1,COG1175@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component MAG.T1.121_03068 1869.MB27_22065 2.2e-111 409.5 Micromonosporales ko:K10118,ko:K10200 ko02010,map02010 M00196,M00205 ko00000,ko00001,ko00002,ko02000 3.A.1.1.18,3.A.1.1.28 Bacteria 2GJM5@201174,4DB06@85008,COG1653@1,COG1653@2 NA|NA|NA G Bacterial extracellular solute-binding protein MAG.T1.121_03069 1410620.SHLA_23c000830 4e-61 242.7 Rhizobiaceae Bacteria 1MUPE@1224,2TS4U@28211,4BB37@82115,COG0747@1,COG0747@2 NA|NA|NA E Bacterial extracellular solute-binding proteins, family 5 Middle MAG.T1.121_03070 471854.Dfer_3132 3e-113 415.6 Cytophagia Bacteria 47MUC@768503,4NFDY@976,COG1070@1,COG1070@2 NA|NA|NA G FGGY family of carbohydrate kinases, C-terminal domain MAG.T1.121_03071 743719.PaelaDRAFT_1334 2.5e-89 335.9 Paenibacillaceae rhaB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0008993,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0019200,GO:0019299,GO:0019301,GO:0019318,GO:0019320,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046365,GO:0046835,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901575 2.7.1.5 ko:K00848 ko00040,ko00051,ko01120,map00040,map00051,map01120 R01902,R03014 RC00002,RC00017 ko00000,ko00001,ko01000 iEcE24377_1341.EcE24377A_4435 Bacteria 1TP7Z@1239,26RVA@186822,4HB5X@91061,COG1070@1,COG1070@2 NA|NA|NA G Involved in the catabolism of L-rhamnose (6-deoxy-L- mannose). Catalyzes the transfer of the gamma-phosphate group from ATP to the 1-hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate MAG.T1.121_03073 525904.Tter_0833 3.1e-153 548.5 unclassified Bacteria gnd GO:0003674,GO:0003824,GO:0004616,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006081,GO:0006082,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019362,GO:0019520,GO:0019521,GO:0019637,GO:0019682,GO:0019693,GO:0019752,GO:0032787,GO:0034641,GO:0042802,GO:0042803,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046176,GO:0046177,GO:0046395,GO:0046483,GO:0046496,GO:0046983,GO:0051156,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072329,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 1.1.1.343,1.1.1.44 ko:K00033 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200 M00004,M00006 R01528,R10221 RC00001,RC00539 ko00000,ko00001,ko00002,ko01000 iECS88_1305.ECS88_2128,iECW_1372.ECW_m2189,iEKO11_1354.EKO11_1765,iPC815.YPO1541,iWFL_1372.ECW_m2189 Bacteria 2NS40@2323,COG0362@1,COG0362@2 NA|NA|NA G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH MAG.T1.121_03074 1286631.X805_25230 5.1e-14 85.1 Betaproteobacteria ko:K07075 ko00000 Bacteria 1N81V@1224,2VX1X@28216,COG1669@1,COG1669@2 NA|NA|NA S Nucleotidyltransferase domain MAG.T1.121_03075 861299.J421_2867 7.6e-94 350.5 Gemmatimonadetes tal 1.1.1.343,1.1.1.44,2.2.1.2,5.3.1.9 ko:K00033,ko:K00616,ko:K13810 ko00010,ko00030,ko00480,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00480,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00004,M00006,M00007,M00114 R01528,R01827,R02739,R02740,R03321,R10221 RC00001,RC00376,RC00439,RC00539,RC00563,RC00604 ko00000,ko00001,ko00002,ko01000 Bacteria 1ZSZV@142182,COG0176@1,COG0176@2 NA|NA|NA G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway MAG.T1.121_03077 419947.MRA_0616 3.5e-27 127.9 Mycobacteriaceae GO:0008150,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0065007 ko:K19686 ko00000,ko01000,ko02048 Bacteria 239GT@1762,2IS39@201174,COG3742@1,COG3742@2 NA|NA|NA S Toxic component of a toxin-antitoxin (TA) module. An RNase MAG.T1.121_03078 479434.Sthe_0516 4.8e-177 628.2 Chloroflexi polB 2.7.7.7 ko:K02336,ko:K06877,ko:K07501 ko00000,ko01000,ko03400 Bacteria 2G7ZM@200795,COG0417@1,COG0417@2 NA|NA|NA L SMART DNA-directed DNA polymerase B MAG.T1.121_03079 929712.KI912613_gene918 1.3e-13 85.1 Rubrobacteria Bacteria 2I4C3@201174,4CQSU@84995,COG0823@1,COG0823@2 NA|NA|NA U Involved in the tonB-independent uptake of proteins MAG.T1.121_03080 240292.Ava_C0006 4e-36 158.7 Nostocales Bacteria 1G31G@1117,1HSVK@1161,COG0500@1,COG2226@2 NA|NA|NA Q Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MAG.T1.121_03082 748247.AZKH_4405 1.1e-62 246.9 Proteobacteria Bacteria 1R4UB@1224,COG1028@1,COG1028@2 NA|NA|NA IQ Dehydrogenases with different specificities (Related to short-chain alcohol dehydrogenases) MAG.T1.121_03084 235909.GK1954 9.5e-56 224.2 Geobacillus hprA 1.1.1.28,1.1.1.399,1.1.1.95 ko:K00058,ko:K03778 ko00260,ko00620,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00620,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R00704,R01513 RC00031,RC00044 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1TQ7W@1239,1WG92@129337,4HDEC@91061,COG0111@1,COG0111@2 NA|NA|NA C D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain MAG.T1.121_03085 485913.Krac_1241 1.3e-53 216.9 Bacteria Bacteria COG2141@1,COG2141@2 NA|NA|NA C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases MAG.T1.121_03086 479434.Sthe_2032 2.8e-71 275.4 Thermomicrobia 3.5.2.6 ko:K17836 ko00311,ko01130,ko01501,map00311,map01130,map01501 M00627,M00628 R06363 RC01499 ko00000,ko00001,ko00002,ko01000,ko01504 Bacteria 27Z5G@189775,2GBEG@200795,COG2367@1,COG2367@2 NA|NA|NA V Beta-lactamase enzyme family MAG.T1.121_03087 386456.JQKN01000022_gene62 1.7e-135 490.0 Euryarchaeota Archaea 2Y2ME@28890,COG5621@1,arCOG12321@2157 NA|NA|NA S Lipocalin-like domain MAG.T1.121_03088 1217718.ALOU01000005_gene1521 6.2e-80 304.3 Burkholderiaceae Bacteria 1KH5I@119060,1MUPW@1224,2VNG1@28216,COG0277@1,COG0277@2 NA|NA|NA C Berberine and berberine like MAG.T1.121_03089 1402135.SUH3_13300 1.5e-40 174.1 Alphaproteobacteria Bacteria 1MXH6@1224,2U25J@28211,COG0739@1,COG0739@2 NA|NA|NA M Peptidase family M23 MAG.T1.121_03090 526226.Gbro_0284 3e-64 252.7 Gordoniaceae Bacteria 2GJEG@201174,4GEB2@85026,COG4585@1,COG4585@2 NA|NA|NA T Histidine kinase MAG.T1.121_03091 58123.JOFJ01000006_gene254 1.2e-70 273.1 Streptosporangiales Bacteria 2GJ46@201174,4EG5F@85012,COG2197@1,COG2197@2 NA|NA|NA T helix_turn_helix, Lux Regulon MAG.T1.121_03094 1150626.PHAMO_340111 3.3e-71 276.2 Rhodospirillales ko:K06160 ko02010,map02010 ko00000,ko00001,ko02000 3.A.1.113.2 Bacteria 1MVIC@1224,2JQ64@204441,2TRME@28211,COG4615@1,COG4615@2 NA|NA|NA PQ COG4615 ABC-type siderophore export system, fused ATPase and permease components MAG.T1.121_03096 452637.Oter_1955 2.8e-27 128.6 Bacteria Bacteria COG3597@1,COG3597@2 NA|NA|NA S protein domain associated with MAG.T1.121_03097 1254432.SCE1572_19685 4.3e-19 100.1 Myxococcales ko:K05375 ko00261,ko01130,map00261,map01130 M00736 R10880 RC00064,RC00141,RC03296,RC03297,RC03298 ko00000,ko00001,ko00002 Bacteria 1PIM5@1224,2X933@28221,2Z1NR@29,434YY@68525,COG3251@1,COG3251@2 NA|NA|NA S MbtH-like protein MAG.T1.121_03098 309801.trd_0234 4.4e-144 517.7 Thermomicrobia aroC GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 iE2348C_1286.E2348C_2469,iEC55989_1330.EC55989_2573,iECO103_1326.ECO103_2794,iECO111_1330.ECO111_3077,iECO26_1355.ECO26_3317,iECSE_1348.ECSE_2638,iECW_1372.ECW_m2518,iEKO11_1354.EKO11_1436,iIT341.HP0663,iSSON_1240.SSON_2387,iUMNK88_1353.UMNK88_2882,iWFL_1372.ECW_m2518 Bacteria 27XHB@189775,2G645@200795,COG0082@1,COG0082@2 NA|NA|NA E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system MAG.T1.121_03099 309801.trd_0237 9.8e-45 187.2 Thermomicrobia 2.1.1.301 ko:K21459 ko00000,ko01000 Bacteria 27Y5W@189775,2G6N8@200795,COG0500@1,COG2226@2 NA|NA|NA Q ubiE/COQ5 methyltransferase family MAG.T1.121_03100 479434.Sthe_0982 4e-41 174.5 Thermomicrobia smpB GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0070930,GO:0071704,GO:0097159,GO:1901363,GO:1901564 ko:K03664 ko00000 Bacteria 27YCP@189775,2G6NE@200795,COG0691@1,COG0691@2 NA|NA|NA O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA MAG.T1.121_03103 340177.Cag_1360 8.9e-14 82.8 Chlorobi ko:K09803 ko00000 Bacteria 1FFFG@1090,COG2929@1,COG2929@2 NA|NA|NA S Ribonuclease toxin, BrnT, of type II toxin-antitoxin system MAG.T1.121_03104 1385520.N802_09670 5.1e-94 351.7 Intrasporangiaceae ydeG Bacteria 2IIAH@201174,4FK06@85021,COG0477@1,COG0477@2 NA|NA|NA EGP Major Facilitator Superfamily MAG.T1.121_03106 1120960.ATXG01000013_gene3437 4.8e-09 67.8 Actinobacteria Bacteria 2H37X@201174,COG5479@1,COG5479@2 NA|NA|NA M Esterase MAG.T1.121_03107 227377.CBU_1788 5.7e-38 164.1 Gammaproteobacteria Bacteria 1RGWX@1224,1SPE9@1236,COG0449@1,COG0449@2 NA|NA|NA M ORF6N domain MAG.T1.121_03108 797114.C475_09584 4.4e-09 66.6 Halobacteria polX ko:K02347 ko00000,ko03400 Archaea 23SYU@183963,2XT14@28890,COG1796@1,arCOG00305@2157 NA|NA|NA L DNA polymerase IV (family X) MAG.T1.121_03109 383372.Rcas_3842 1.3e-11 75.9 Chloroflexia ko:K02035 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 2G8DD@200795,377K1@32061,COG0747@1,COG0747@2 NA|NA|NA E PFAM extracellular solute-binding protein, family 5 MAG.T1.121_03110 469383.Cwoe_0131 3.5e-89 335.1 Actinobacteria ko:K02033 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 2GK0Z@201174,COG0601@1,COG0601@2 NA|NA|NA EP PFAM binding-protein-dependent transport systems inner membrane component MAG.T1.121_03111 383372.Rcas_3840 8.4e-85 320.5 Chloroflexia ko:K02034,ko:K15582 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 2G6HB@200795,375I1@32061,COG1173@1,COG1173@2 NA|NA|NA P PFAM binding-protein-dependent transport systems inner membrane component MAG.T1.121_03112 1123508.JH636448_gene7663 6.8e-71 274.2 Planctomycetes 3.5.2.10 ko:K01470 ko00330,map00330 R01884 RC00615 ko00000,ko00001,ko01000 Bacteria 2IYP1@203682,COG1402@1,COG1402@2 NA|NA|NA S Creatinine amidohydrolase MAG.T1.121_03114 572477.Alvin_1390 5.6e-20 103.2 Chromatiales selB GO:0000049,GO:0000166,GO:0001514,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006412,GO:0006414,GO:0006417,GO:0006451,GO:0006518,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009069,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016259,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034248,GO:0034641,GO:0034645,GO:0035368,GO:0035639,GO:0036094,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:2000112 ko:K03833 ko00000,ko03012 Bacteria 1MWXH@1224,1RQJI@1236,1X0BT@135613,COG3276@1,COG3276@2 NA|NA|NA J Elongation factor SelB, winged helix MAG.T1.121_03116 1502851.FG93_02996 3.1e-77 295.4 Bradyrhizobiaceae appB GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0022857,GO:0051179,GO:0051234,GO:0055085 ko:K02033 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 1MU8Z@1224,2TQJC@28211,3JU9K@41294,COG0601@1,COG0601@2 NA|NA|NA EP Binding-protein-dependent transport system inner membrane component MAG.T1.121_03117 1235279.C772_01046 8.8e-60 238.4 Planococcaceae appA ko:K02035 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 1TQ0N@1239,26H18@186818,4HARF@91061,COG0747@1,COG0747@2 NA|NA|NA E Bacterial extracellular solute-binding proteins, family 5 Middle MAG.T1.121_03118 479434.Sthe_2516 2.2e-35 155.2 Thermomicrobia yuxL 3.4.19.1 ko:K01303 ko00000,ko01000,ko01002 Bacteria 27Y10@189775,2G5Q5@200795,COG0823@1,COG0823@2,COG1506@1,COG1506@2 NA|NA|NA EU PFAM peptidase S9 prolyl oligopeptidase active site domain protein MAG.T1.121_03119 1223542.GM1_011_01550 1.4e-41 176.0 Gordoniaceae yjaB ko:K03827 ko00000,ko01000 Bacteria 2IMKB@201174,4GESU@85026,COG0454@1,COG0456@2 NA|NA|NA K Acetyltransferase (GNAT) domain MAG.T1.121_03121 502025.Hoch_1477 2.9e-74 285.8 Myxococcales nagA GO:0003674,GO:0003824,GO:0005488,GO:0006040,GO:0006044,GO:0006046,GO:0006054,GO:0006082,GO:0008150,GO:0008152,GO:0008270,GO:0008448,GO:0009056,GO:0009987,GO:0016043,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0016999,GO:0017001,GO:0017144,GO:0019213,GO:0019262,GO:0019752,GO:0022607,GO:0042737,GO:0043167,GO:0043169,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046348,GO:0046395,GO:0046872,GO:0046914,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901071,GO:1901072,GO:1901135,GO:1901136,GO:1901575 3.5.1.25 ko:K01443 ko00520,ko01130,map00520,map01130 R02059 RC00166,RC00300 ko00000,ko00001,ko01000 iEcolC_1368.EcolC_2979,iYL1228.KPN_00698 Bacteria 1MW8Y@1224,2WVQI@28221,2Z0VP@29,430VJ@68525,COG1820@1,COG1820@2 NA|NA|NA G Belongs to the metallo-dependent hydrolases superfamily. NagA family MAG.T1.121_03122 1382306.JNIM01000001_gene1419 1.3e-61 243.4 Chloroflexi nagk GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0006040,GO:0006044,GO:0006082,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017076,GO:0019200,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0045127,GO:0046835,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901071,GO:1901135,GO:1901265,GO:1901363 2.7.1.59 ko:K00884 ko00520,ko01100,map00520,map01100 R01201 RC00002,RC00017 ko00000,ko00001,ko01000 Bacteria 2G6Y6@200795,COG2971@1,COG2971@2 NA|NA|NA G BadF/BadG/BcrA/BcrD ATPase family MAG.T1.121_03123 1382306.JNIM01000001_gene1420 2.9e-79 302.0 Chloroflexi murQ 4.2.1.126 ko:K07106 ko00520,ko01100,map00520,map01100 R08555 RC00397,RC00746 ko00000,ko00001,ko01000 Bacteria 2G6DC@200795,COG2103@1,COG2103@2 NA|NA|NA G Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate MAG.T1.121_03126 1121920.AUAU01000018_gene1775 1.4e-20 106.3 Acidobacteria Bacteria 3Y4HW@57723,COG2318@1,COG2318@2 NA|NA|NA S Mycothiol maleylpyruvate isomerase N-terminal domain MAG.T1.121_03127 485913.Krac_11734 1.7e-49 203.0 Bacteria yjjK ko:K06158 ko00000,ko03012 Bacteria COG0488@1,COG0488@2 NA|NA|NA L (ABC) transporter MAG.T1.121_03130 1183438.GKIL_4239 1.5e-52 213.0 Cyanobacteria rpiA GO:0003674,GO:0003824,GO:0004751,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 2.7.1.12,2.7.1.15,5.3.1.6 ko:K00851,ko:K00852,ko:K01807 ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167,M00580 R01051,R01056,R01737,R02750 RC00002,RC00017,RC00434 ko00000,ko00001,ko00002,ko01000 Bacteria 1G2DW@1117,COG0120@1,COG0120@2 NA|NA|NA G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate MAG.T1.121_03131 671143.DAMO_0485 5.6e-48 198.0 unclassified Bacteria pgl 3.1.1.31 ko:K01057 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R02035 RC00537 ko00000,ko00001,ko00002,ko01000 Bacteria 2NPBM@2323,COG0363@1,COG0363@2 NA|NA|NA G Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase MAG.T1.121_03132 357808.RoseRS_2561 1.6e-25 124.0 Chloroflexia opcA Bacteria 2G6ZV@200795,375YF@32061,COG3429@1,COG3429@2 NA|NA|NA G Glucose-6-phosphate dehydrogenase subunit MAG.T1.121_03135 1286631.X805_28900 1.8e-31 142.5 unclassified Burkholderiales MA20_23315 Bacteria 1KMHB@119065,1R9XU@1224,2VVGN@28216,COG1765@1,COG1765@2 NA|NA|NA O OsmC-like protein MAG.T1.121_03136 661478.OP10G_4301 2.5e-52 211.8 Bacteria 5.2.1.8 ko:K03767,ko:K03768 ko01503,ko04217,map01503,map04217 ko00000,ko00001,ko01000,ko03110,ko04147 Bacteria COG0652@1,COG0652@2 NA|NA|NA O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides MAG.T1.121_03137 1453501.JELR01000002_gene1349 5.7e-38 164.1 Alteromonadaceae vsr ko:K07458 ko00000,ko01000,ko03400 Bacteria 1RH1C@1224,1S2V3@1236,468PZ@72275,COG3727@1,COG3727@2 NA|NA|NA L May nick specific sequences that contain T G mispairs resulting from m5C-deamination MAG.T1.121_03138 1187851.A33M_2229 1.8e-108 399.4 Rhodovulum ydiP GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006304,GO:0006305,GO:0006306,GO:0006725,GO:0006807,GO:0006950,GO:0006952,GO:0008150,GO:0008152,GO:0008168,GO:0009307,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0032776,GO:0034641,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044355,GO:0044728,GO:0046483,GO:0050896,GO:0071704,GO:0090304,GO:0099046,GO:1901360 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 Bacteria 1PPPQ@1224,2VAY9@28211,3FEJB@34008,COG0270@1,COG0270@2 NA|NA|NA L C-5 cytosine-specific DNA methylase MAG.T1.121_03139 76114.ebA5218 2.9e-72 278.9 Rhodocyclales 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 1MX81@1224,2KXSP@206389,2VHKR@28216,COG2378@1,COG2378@2 NA|NA|NA K WYL domain MAG.T1.121_03141 290400.Jann_0885 1.5e-66 259.6 Alphaproteobacteria 3.6.3.17 ko:K02056 M00221 ko00000,ko00002,ko01000,ko02000 3.A.1.2 Bacteria 1MVNR@1224,2TTCM@28211,COG1129@1,COG1129@2 NA|NA|NA G ABC transporter MAG.T1.121_03142 688269.Theth_0468 5.8e-50 204.9 Thermotogae 3.2.1.81 ko:K01219,ko:K21000 ko02025,map02025 ko00000,ko00001,ko01000 GH39 Bacteria 2GDXZ@200918,COG1874@1,COG1874@2 NA|NA|NA G Beta-galactosidase MAG.T1.121_03143 1122132.AQYH01000005_gene753 2.3e-42 179.9 Rhizobiaceae 3.2.1.11 ko:K05988 ko00500,map00500 R11309 ko00000,ko00001,ko01000 GH66 Bacteria 1PU80@1224,2V5ZY@28211,4BIUN@82115,COG1649@1,COG1649@2 NA|NA|NA S PFAM Uncharacterised BCR, COG1649 MAG.T1.121_03144 1122132.AQYH01000005_gene756 3.9e-36 157.9 Rhizobiaceae ko:K10439 ko02010,ko02030,map02010,map02030 M00212 ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 Bacteria 1NRXG@1224,2U2SD@28211,4BB6N@82115,COG1879@1,COG1879@2 NA|NA|NA G Periplasmic binding protein MAG.T1.121_03145 446466.Cfla_0815 1.1e-19 103.6 Actinobacteria ko:K06978 ko00000 Bacteria 2GK8B@201174,COG2936@1,COG2936@2 NA|NA|NA IQ Peptidase S15 MAG.T1.121_03147 525904.Tter_2662 2.8e-93 348.2 unclassified Bacteria fpaP 3.4.11.5 ko:K01259 ko00330,map00330 R00135 ko00000,ko00001,ko01000,ko01002 Bacteria 2NRKH@2323,COG2267@1,COG2267@2 NA|NA|NA I Alpha/beta hydrolase family MAG.T1.121_03148 479434.Sthe_0515 3.2e-61 241.9 Thermomicrobia ko:K07010 ko00000,ko01002 Bacteria 27YBG@189775,2G6QN@200795,COG2071@1,COG2071@2 NA|NA|NA S Peptidase C26 MAG.T1.121_03149 1172188.KB911820_gene2492 4e-24 117.5 Intrasporangiaceae Bacteria 2IKX6@201174,4FHHN@85021,COG3324@1,COG3324@2 NA|NA|NA S DinB family MAG.T1.121_03150 1123320.KB889704_gene9398 1.8e-58 233.0 Actinobacteria MA20_06780 ko:K03088 ko00000,ko03021 Bacteria 2GJIZ@201174,COG1595@1,COG1595@2 NA|NA|NA K belongs to the sigma-70 factor family, ECF subfamily MAG.T1.121_03151 479434.Sthe_0514 5.3e-173 614.0 Thermomicrobia lon 3.4.21.53 ko:K01338 ko04112,map04112 ko00000,ko00001,ko01000,ko01002 Bacteria 27XY6@189775,2G5TZ@200795,COG0466@1,COG0466@2 NA|NA|NA O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner MAG.T1.121_03152 395961.Cyan7425_0123 1e-81 311.2 Cyanothece Bacteria 1G7IV@1117,3KK2T@43988,COG0596@1,COG0596@2 NA|NA|NA S TAP-like protein MAG.T1.121_03153 479431.Namu_0035 5.7e-14 84.3 Frankiales Bacteria 2E4RI@1,2GTNG@201174,32ZK2@2,4EWHW@85013 NA|NA|NA MAG.T1.121_03154 485913.Krac_1587 6.4e-84 317.8 Bacteria Bacteria 2C57D@1,2Z7RS@2 NA|NA|NA S Protein of unknown function (DUF2891) MAG.T1.121_03156 1385520.N802_06780 3e-14 84.7 Intrasporangiaceae Bacteria 2IIYT@201174,4FGR2@85021,COG1670@1,COG1670@2 NA|NA|NA J Acetyltransferase (GNAT) domain MAG.T1.121_03157 1304865.JAGF01000001_gene433 1.5e-249 869.4 Cellulomonadaceae ko:K03556 ko00000,ko03000 Bacteria 2IBFJ@201174,4F2IF@85016,COG2909@1,COG2909@2 NA|NA|NA K helix_turn_helix, Lux Regulon MAG.T1.121_03158 1382356.JQMP01000003_gene2005 7.5e-100 370.5 Thermomicrobia MA20_03545 ko:K02025,ko:K02026,ko:K15771 ko02010,map02010 M00207,M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.2 Bacteria 27Z2H@189775,2GA2Q@200795,COG1175@1,COG1175@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component MAG.T1.121_03159 1382356.JQMP01000003_gene2004 4.2e-139 501.5 Thermomicrobia ko:K02027 M00207 ko00000,ko00002,ko02000 3.A.1.1 Bacteria 27Z27@189775,2GBCK@200795,COG1653@1,COG1653@2 NA|NA|NA G Bacterial extracellular solute-binding protein MAG.T1.121_03161 66869.JNXG01000006_gene1625 2e-116 426.4 Streptomyces griseus group trxB2 1.8.1.9 ko:K00384 ko00450,map00450 R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 Bacteria 2GKD2@201174,4193H@629295,COG0492@1,COG0492@2 NA|NA|NA O Pyridine nucleotide-disulphide oxidoreductase MAG.T1.121_03162 479434.Sthe_3255 9.4e-155 553.5 Thermomicrobia 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 Bacteria 27XWA@189775,2G7WJ@200795,COG0154@1,COG0154@2 NA|NA|NA J Belongs to the amidase family MAG.T1.121_03163 309801.trd_1436 1.6e-19 102.1 Thermomicrobia yggW GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 Bacteria 27XYQ@189775,2G5NK@200795,COG0635@1,COG0635@2 NA|NA|NA H Involved in the biosynthesis of porphyrin-containing compound MAG.T1.121_03166 479434.Sthe_0227 0.0 1462.2 Thermomicrobia dnaE2 GO:0000731,GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019985,GO:0030312,GO:0031668,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042276,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.6,2.7.7.7 ko:K00960,ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 27Z3J@189775,2G811@200795,COG0587@1,COG0587@2 NA|NA|NA L Belongs to the DNA polymerase type-C family. DnaE2 subfamily MAG.T1.121_03167 309801.trd_1442 1.5e-34 152.9 Thermomicrobia Bacteria 27Y54@189775,2G8NG@200795,COG2141@1,COG2141@2 NA|NA|NA C Luciferase-like monooxygenase MAG.T1.121_03168 28444.JODQ01000001_gene2026 3.1e-31 141.4 Streptosporangiales Bacteria 2IHMX@201174,4EJUK@85012,COG1917@1,COG1917@2 NA|NA|NA S Cupin 2, conserved barrel domain protein MAG.T1.121_03169 479434.Sthe_2746 1.4e-126 459.5 Bacteria nit2 3.5.5.1 ko:K01501 ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00380,map00460,map00627,map00643,map00910,map01120 R00540,R01887,R03093,R03542,R05591,R07855 RC00315,RC00325,RC00617,RC00959,RC02811 ko00000,ko00001,ko01000 Bacteria COG0388@1,COG0388@2 NA|NA|NA S hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds MAG.T1.121_03172 697281.Mahau_0141 2.9e-59 235.7 Thermoanaerobacterales ko:K02025,ko:K10118,ko:K15771 ko02010,map02010 M00196,M00207,M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.2,3.A.1.1.28 Bacteria 1TREE@1239,24B75@186801,42I1V@68295,COG1175@1,COG1175@2 NA|NA|NA P PFAM binding-protein-dependent transport systems inner membrane component MAG.T1.121_03173 697281.Mahau_1152 5.9e-56 224.6 Thermoanaerobacterales ko:K02026 M00207 ko00000,ko00002,ko02000 3.A.1.1 Bacteria 1TRCP@1239,249NY@186801,42HXI@68295,COG0395@1,COG0395@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component MAG.T1.121_03174 1449044.JMLE01000026_gene1578 6e-26 124.8 Actinobacteria 4.2.1.44 ko:K03335 ko00562,ko01100,ko01120,map00562,map01100,map01120 R02782,R05659 RC00782,RC01448 ko00000,ko00001,ko01000 Bacteria 2GJKJ@201174,COG1082@1,COG1082@2 NA|NA|NA G dehydratase MAG.T1.121_03176 926550.CLDAP_13690 5.9e-62 244.6 Chloroflexi xylB_2 2.7.1.12,2.7.1.17,2.7.1.215,2.7.1.5 ko:K00848,ko:K00851,ko:K00854,ko:K00862 ko00030,ko00040,ko00051,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00040,map00051,map01100,map01110,map01120,map01130,map01200 M00014 R01639,R01737,R01902,R03014,R11536 RC00002,RC00017,RC00538 ko00000,ko00001,ko00002,ko01000 Bacteria 2G5QX@200795,COG1070@1,COG1070@2 NA|NA|NA G PFAM carbohydrate kinase MAG.T1.121_03177 211114.JOEF01000001_gene7483 3.4e-91 342.4 Pseudonocardiales xylB 1.1.1.57,2.7.1.17 ko:K00040,ko:K00854,ko:K19168 ko00040,ko01100,map00040,map01100 M00014,M00061 R01639,R02454 RC00002,RC00085,RC00538 ko00000,ko00001,ko00002,ko01000,ko02048 Bacteria 2GJDZ@201174,4DXQ6@85010,COG1070@1,COG1070@2 NA|NA|NA G PFAM FGGY family of carbohydrate kinases, N-terminal domain MAG.T1.121_03178 1173026.Glo7428_0635 4.2e-123 448.0 Bacteria 5.3.1.8 ko:K01809 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01819 RC00376 ko00000,ko00001,ko00002,ko01000 Bacteria COG1482@1,COG1482@2 NA|NA|NA G cell wall glycoprotein biosynthetic process MAG.T1.121_03180 485913.Krac_5266 1.1e-46 194.1 Bacteria Bacteria COG0673@1,COG0673@2 NA|NA|NA S inositol 2-dehydrogenase activity MAG.T1.121_03181 479434.Sthe_0690 4.1e-26 125.9 Chloroflexi Bacteria 2G73Y@200795,COG1670@1,COG1670@2 NA|NA|NA J PFAM GCN5-related N-acetyltransferase MAG.T1.121_03182 479434.Sthe_0826 3.5e-148 531.6 Thermomicrobia fixC ko:K00313 ko00000,ko01000 Bacteria 27XS1@189775,2G68K@200795,COG0644@1,COG0644@2 NA|NA|NA C HI0933-like protein MAG.T1.121_03183 662479.C440_09903 1.1e-117 430.6 Halobacteria 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 R03187 RC00632 ko00000,ko00001,ko01000 Archaea 23UBX@183963,2XW5V@28890,COG0146@1,arCOG01512@2157 NA|NA|NA E COG0146 N-methylhydantoinase B acetone carboxylase, alpha subunit MAG.T1.121_03184 1411123.JQNH01000001_gene3693 6.3e-09 66.6 Alphaproteobacteria oplaH 3.5.2.14,3.5.2.9 ko:K01469,ko:K01473,ko:K01474 ko00330,ko00480,ko01100,map00330,map00480,map01100 R00251,R03187 RC00553,RC00632 ko00000,ko00001,ko01000 Bacteria 1MU2Y@1224,2TQZ6@28211,COG0145@1,COG0145@2,COG0146@1,COG0146@2 NA|NA|NA EQ N-methylhydantoinase A acetone carboxylase, beta subunit MAG.T1.121_03186 1100721.ALKO01000003_gene2174 9.7e-153 547.0 Comamonadaceae purD GO:0000166,GO:0003674,GO:0003824,GO:0004637,GO:0005488,GO:0005524,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 iECNA114_1301.ECNA114_3417,iECSF_1327.ECSF_3859,iJN746.PP_4823,iPC815.YPO3729 Bacteria 1MUAH@1224,2VH9J@28216,4A9X8@80864,COG0151@1,COG0151@2 NA|NA|NA F Belongs to the GARS family MAG.T1.121_03187 1382306.JNIM01000001_gene2710 1.5e-25 124.0 Chloroflexi Bacteria 2G72S@200795,COG5542@1,COG5542@2 NA|NA|NA S integral membrane protein MAG.T1.121_03188 1499967.BAYZ01000074_gene2156 7.1e-70 270.8 Bacteria nudC 1.3.7.1,3.6.1.22 ko:K03426,ko:K20449 ko00760,ko01100,ko01120,ko04146,map00760,map01100,map01120,map04146 R00103,R03004,R03164,R11104 RC00002,RC02422 ko00000,ko00001,ko01000 Bacteria COG2816@1,COG2816@2 NA|NA|NA L NAD+ diphosphatase activity MAG.T1.121_03189 479434.Sthe_1821 4.9e-119 434.5 Thermomicrobia rlmN GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 ko:K06941 ko00000,ko01000,ko03009 Bacteria 27XRH@189775,2G5SD@200795,COG0820@1,COG0820@2 NA|NA|NA J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs MAG.T1.121_03190 479434.Sthe_3511 1.4e-08 66.2 Thermomicrobia Bacteria 27YPX@189775,2GBBU@200795,COG2318@1,COG2318@2 NA|NA|NA S DinB family MAG.T1.121_03191 479434.Sthe_3512 1.8e-24 120.2 Thermomicrobia Bacteria 27YDI@189775,2GB9Q@200795,COG0346@1,COG0346@2 NA|NA|NA E lactoylglutathione lyase activity MAG.T1.121_03192 309801.trd_0184 1.2e-30 140.2 Thermomicrobia 2.7.11.1 ko:K07282,ko:K12132,ko:K15539,ko:K19223 ko00000,ko01000,ko01001,ko01002,ko01011 CBM50 Bacteria 27XPH@189775,2G99E@200795,COG0791@1,COG0791@2,COG3103@1,COG4991@2 NA|NA|NA MT NlpC/P60 family MAG.T1.121_03193 485913.Krac_2758 2.6e-21 108.6 Bacteria Bacteria COG3832@1,COG3832@2 NA|NA|NA J glyoxalase III activity MAG.T1.121_03194 326427.Cagg_3669 1.5e-30 141.4 Chloroflexia MA20_24860 2.7.7.65,2.7.7.7 ko:K02342,ko:K21021 ko00230,ko00240,ko01100,ko02025,ko03030,ko03430,ko03440,map00230,map00240,map01100,map02025,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 2G6F0@200795,377HR@32061,COG4585@1,COG4585@2,COG5000@1,COG5000@2 NA|NA|NA T histidine kinase dimerisation and phosphoacceptor region MAG.T1.121_03195 1121380.JNIW01000027_gene3151 1.4e-41 176.4 Deinococcus-Thermus Bacteria 1WI4W@1297,COG2197@1,COG2197@2 NA|NA|NA T Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain MAG.T1.121_03196 1346791.M529_15955 4.4e-102 377.5 Sphingomonadales clcA_1 ko:K03281 ko00000 2.A.49 Bacteria 1MV4K@1224,2K2S9@204457,2TTBG@28211,COG0038@1,COG0038@2,COG0517@1,COG0517@2 NA|NA|NA P Chloride channel protein MAG.T1.121_03197 1346791.M529_15940 4.6e-194 684.1 Sphingomonadales Bacteria 1MUA8@1224,2K0P4@204457,2TSN8@28211,COG1538@1,COG1538@2 NA|NA|NA M PFAM Outer membrane efflux protein MAG.T1.121_03198 1346791.M529_15935 1.9e-145 521.9 Sphingomonadales ko:K03543 M00701 ko00000,ko00002,ko02000 8.A.1.1 Bacteria 1MWG0@1224,2K38W@204457,2TRI4@28211,COG1566@1,COG1566@2 NA|NA|NA V Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family MAG.T1.121_03199 1346791.M529_15930 2.8e-29 134.0 Sphingomonadales Bacteria 1NH03@1224,2EGFD@1,2K7N6@204457,2UUKD@28211,33A7D@2 NA|NA|NA S Protein of unknown function (DUF1656) MAG.T1.121_03204 448385.sce2619 1.3e-114 419.9 Proteobacteria ko:K09703 ko00000 Bacteria 1NCBV@1224,COG3535@1,COG3535@2 NA|NA|NA S Protein of unknown function (DUF917) MAG.T1.121_03205 675635.Psed_4205 2.6e-21 108.6 Actinobacteria 1.3.3.13 ko:K21375 ko00000,ko01000 Bacteria 2IEFM@201174,COG0778@1,COG0778@2 NA|NA|NA C Nitroreductase family MAG.T1.121_03207 477641.MODMU_1166 9.1e-71 275.4 Frankiales Bacteria 2GIZ1@201174,4EUW7@85013,COG1813@1,COG1813@2,COG3903@1,COG3903@2 NA|NA|NA K Helix-turn-helix domain MAG.T1.121_03209 1382356.JQMP01000003_gene1376 8.8e-89 334.0 Thermomicrobia Bacteria 27YYZ@189775,2GB54@200795,COG1363@1,COG1363@2 NA|NA|NA E M42 glutamyl aminopeptidase MAG.T1.121_03210 891968.Anamo_1310 1.2e-12 79.3 Bacteria ko:K06218 ko00000,ko02048 Bacteria COG2026@1,COG2026@2 NA|NA|NA DJ nuclease activity MAG.T1.121_03212 530564.Psta_4554 1.3e-11 75.9 Planctomycetes pepQ 3.5.3.3 ko:K08688 ko00260,ko00330,ko01100,map00260,map00330,map01100 R01566 RC00548,RC00549 ko00000,ko00001,ko01000 Bacteria 2IZ0S@203682,COG0006@1,COG0006@2 NA|NA|NA E Xaa-Pro aminopeptidase MAG.T1.121_03218 1125863.JAFN01000001_gene3206 1.1e-91 344.0 Deltaproteobacteria Bacteria 1QZ3W@1224,2WM59@28221,42PKB@68525,COG2159@1,COG2159@2 NA|NA|NA L PFAM transposase, IS4 family protein MAG.T1.121_03219 316274.Haur_4664 4.1e-24 119.4 Chloroflexi Bacteria 2GBIY@200795,COG0642@1,COG2205@2 NA|NA|NA T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain MAG.T1.121_03221 525904.Tter_2573 2.3e-95 355.5 Bacteria ko:K02025,ko:K05814,ko:K10118,ko:K10237,ko:K10241,ko:K15771,ko:K17235,ko:K17316 ko02010,map02010 M00196,M00198,M00204,M00206,M00207,M00491,M00602,M00605 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.17,3.A.1.1.2,3.A.1.1.23,3.A.1.1.24,3.A.1.1.28,3.A.1.1.3,3.A.1.1.30,3.A.1.1.34 Bacteria COG1175@1,COG1175@2 NA|NA|NA P transmembrane transport MAG.T1.121_03222 525904.Tter_2574 2.5e-109 402.5 Bacteria ko:K02027 M00207 ko00000,ko00002,ko02000 3.A.1.1 Bacteria COG2182@1,COG2182@2 NA|NA|NA G maltose binding MAG.T1.121_03223 1382306.JNIM01000001_gene1421 1.3e-12 79.0 Chloroflexi ko:K03710 ko00000,ko03000 Bacteria 2G6ST@200795,COG2188@1,COG2188@2 NA|NA|NA K SPTR D1CI93 Phophonate C-P lyase system transcriptional regulator PhnF, GntR family MAG.T1.121_03226 47839.CCAU010000011_gene5282 1.2e-43 183.7 Mycobacteriaceae Bacteria 23AVQ@1762,2GJI7@201174,COG2141@1,COG2141@2 NA|NA|NA C Luciferase-like monooxygenase MAG.T1.121_03228 266835.14026157 6e-19 99.8 Phyllobacteriaceae Bacteria 1NFSK@1224,2U4IW@28211,43J44@69277,COG5486@1,COG5486@2 NA|NA|NA S Predicted metal-binding integral membrane protein (DUF2182) MAG.T1.121_03229 1286093.C266_15432 1.3e-16 92.8 Burkholderiaceae ko:K05710,ko:K14750,ko:K15752 ko00360,ko00621,ko00642,ko01100,ko01120,ko01220,map00360,map00621,map00642,map01100,map01120,map01220 M00544,M00545 R05414,R05440,R06782,R06783,R09512 RC00098,RC01370 br01602,ko00000,ko00001,ko00002 Bacteria 1KA6M@119060,1PED8@1224,2VUQA@28216,COG2146@1,COG2146@2 NA|NA|NA P Rieske [2Fe-2S] domain MAG.T1.121_03230 525904.Tter_1964 2e-28 132.9 Bacteria Bacteria COG1802@1,COG1802@2 NA|NA|NA K Transcriptional regulator MAG.T1.121_03231 1304865.JAGF01000001_gene423 1.5e-13 84.3 Actinobacteria ko:K02027 M00207 ko00000,ko00002,ko02000 3.A.1.1 Bacteria 2GM4E@201174,COG1653@1,COG1653@2 NA|NA|NA G ABC transporter substrate-binding protein MAG.T1.121_03238 1223523.H340_05901 7.3e-91 341.3 Actinobacteria 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 Bacteria 2GN7F@201174,COG0154@1,COG0154@2 NA|NA|NA J Belongs to the amidase family MAG.T1.121_03240 864702.OsccyDRAFT_4275 8.9e-19 99.0 Cyanobacteria pip 3.4.11.5 ko:K01259 ko00330,map00330 R00135 ko00000,ko00001,ko01000,ko01002 Bacteria 1GQMB@1117,COG2267@1,COG2267@2 NA|NA|NA I TIGRFAM proline-specific peptidases, Bacillus coagulans-type subfamily MAG.T1.121_03241 1382356.JQMP01000003_gene1376 1.4e-60 240.0 Thermomicrobia Bacteria 27YYZ@189775,2GB54@200795,COG1363@1,COG1363@2 NA|NA|NA E M42 glutamyl aminopeptidase MAG.T1.121_03242 1229487.AMYW01000005_gene297 1.4e-28 133.3 Flavobacterium comA ko:K07691,ko:K11624,ko:K14989 ko02020,ko02024,map02020,map02024 M00476,M00484,M00522 ko00000,ko00001,ko00002,ko02022 Bacteria 1HYWI@117743,2P03J@237,4NQE7@976,COG2197@1,COG2197@2 NA|NA|NA T helix_turn_helix, Lux Regulon MAG.T1.121_03243 1434325.AZQN01000003_gene2762 2.6e-11 77.0 Bacteroidetes phcR 2.7.13.3 ko:K02484,ko:K07649,ko:K10819,ko:K19622,ko:K20975 ko02020,ko02025,map02020,map02025 M00457,M00820 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 4NK65@976,COG3292@1,COG3292@2,COG4191@1,COG4191@2 NA|NA|NA T Histidine kinase MAG.T1.121_03246 1122132.AQYH01000013_gene1781 2.7e-63 249.6 Rhizobiaceae ko:K02027 M00207 ko00000,ko00002,ko02000 3.A.1.1 Bacteria 1QCBE@1224,2UEGB@28211,4BC87@82115,COG1653@1,COG1653@2 NA|NA|NA G Bacterial extracellular solute-binding protein MAG.T1.121_03247 1122132.AQYH01000013_gene1780 1.2e-70 273.5 Rhizobiaceae ko:K02025,ko:K15771 ko02010,map02010 M00207,M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.2 Bacteria 1RDF1@1224,2U92C@28211,4B9HG@82115,COG1175@1,COG1175@2 NA|NA|NA G Binding-protein-dependent transport system inner membrane component MAG.T1.121_03248 290397.Adeh_2304 8.8e-33 146.0 Myxococcales Bacteria 1NR6J@1224,2WIND@28221,2YUEV@29,42MYN@68525,COG0243@1,COG0243@2 NA|NA|NA C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family MAG.T1.121_03250 1121898.Q766_08120 2.4e-32 145.2 Flavobacterium Bacteria 1I2GF@117743,2NVZA@237,4NPAB@976,COG3832@1,COG3832@2 NA|NA|NA J glyoxalase III activity MAG.T1.121_03251 357808.RoseRS_2309 3e-13 80.5 Chloroflexia Bacteria 2DSCK@1,2GAKK@200795,32USS@2,376NF@32061 NA|NA|NA MAG.T1.121_03253 357808.RoseRS_2309 2.7e-14 83.6 Chloroflexia Bacteria 2DSCK@1,2GAKK@200795,32USS@2,376NF@32061 NA|NA|NA MAG.T1.121_03254 68194.JNXR01000019_gene3443 2.7e-115 422.2 Actinobacteria patB 4.4.1.8 ko:K14155 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 R00782,R01286,R02408,R04941 RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko01000,ko01007 Bacteria 2GJFQ@201174,COG1168@1,COG1168@2 NA|NA|NA E Aminotransferase, class I MAG.T1.121_03255 1445613.JALM01000003_gene5055 1.5e-36 159.8 Bacteria 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 Bacteria COG0451@1,COG0451@2 NA|NA|NA GM ADP-glyceromanno-heptose 6-epimerase activity MAG.T1.121_03256 1122182.KB903834_gene6099 2.1e-99 369.4 Micromonosporales Bacteria 2GJPB@201174,4D8ES@85008,COG4292@1,COG4292@2 NA|NA|NA S Bacterial low temperature requirement A protein (LtrA) MAG.T1.121_03257 479434.Sthe_3043 5.9e-52 211.5 Bacteria Bacteria COG0111@1,COG0111@2 NA|NA|NA EH 4-phosphoerythronate dehydrogenase activity MAG.T1.121_03258 1123054.KB907744_gene3527 6e-160 570.5 Chromatiales acrA ko:K02005 ko00000 Bacteria 1PDUT@1224,1RQKD@1236,1WX86@135613,COG0845@1,COG0845@2 NA|NA|NA M HlyD family secretion protein MAG.T1.121_03259 76114.ebA6247 7.5e-85 320.1 Rhodocyclales Bacteria 1MWF7@1224,2KY5C@206389,2VMVD@28216,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family MAG.T1.121_03260 1346791.M529_15530 4.2e-23 114.0 Sphingomonadales ko:K07733 ko00000,ko03000 Bacteria 1N8T4@1224,2K7M1@204457,2UIRE@28211,COG3311@1,COG3311@2 NA|NA|NA K Prophage CP4-57 regulatory protein (AlpA) MAG.T1.121_03262 927658.AJUM01000017_gene3087 1.2e-76 294.3 Bacteria Bacteria COG4935@1,COG4935@2 NA|NA|NA O Belongs to the peptidase S8 family MAG.T1.121_03264 479434.Sthe_0669 1.5e-228 799.3 Thermomicrobia mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 ko:K03555 ko03430,map03430 ko00000,ko00001,ko03400 Bacteria 27XRG@189775,2G5IU@200795,COG0249@1,COG0249@2 NA|NA|NA L that it carries out the mismatch recognition step. This protein has a weak ATPase activity MAG.T1.121_03268 479434.Sthe_2501 6.9e-26 123.6 Chloroflexi ko:K07005 ko00000 Bacteria 2G77X@200795,COG3467@1,COG3467@2 NA|NA|NA S PFAM pyridoxamine 5'-phosphate oxidase-related MAG.T1.121_03272 383372.Rcas_3851 1.4e-83 316.2 Chloroflexia Bacteria 2GAK3@200795,3774Y@32061,COG1028@1,COG1028@2 NA|NA|NA IQ PFAM short-chain dehydrogenase reductase SDR MAG.T1.121_03274 717606.PaecuDRAFT_0479 2e-13 81.3 Paenibacillaceae yoqW Bacteria 1TRRV@1239,26T4Z@186822,4HDUN@91061,COG2135@1,COG2135@2 NA|NA|NA S Belongs to the SOS response-associated peptidase family MAG.T1.121_03276 1298860.AUEM01000002_gene805 4.7e-51 208.8 Microbacteriaceae Bacteria 2I2FE@201174,4FMFJ@85023,COG2267@1,COG2267@2 NA|NA|NA I Secretory lipase MAG.T1.121_03281 1071679.BG57_25805 1.8e-57 229.2 Burkholderiaceae paiB ko:K07734 ko00000,ko03000 Bacteria 1K21D@119060,1N1B9@1224,2VRAJ@28216,COG2808@1,COG2808@2 NA|NA|NA K Transcriptional regulator MAG.T1.121_03288 1122609.AUGT01000013_gene4106 2.1e-08 65.1 Propionibacteriales Bacteria 2DNVA@1,2GRAT@201174,32ZBE@2,4DSW5@85009 NA|NA|NA MAG.T1.121_03290 378806.STAUR_7361 2.6e-68 266.2 Proteobacteria Bacteria 1NHID@1224,2E4RD@1,302H1@2 NA|NA|NA MAG.T1.121_03292 1146883.BLASA_1105 1.2e-45 189.9 Frankiales ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GRE8@201174,4EUE6@85013,COG1131@1,COG1131@2 NA|NA|NA V ABC transporter MAG.T1.121_03293 67352.JODS01000008_gene7296 3.9e-39 168.7 Actinobacteria Bacteria 2GM0N@201174,COG1277@1,COG1277@2 NA|NA|NA V ABC-type transport system involved in multi-copper enzyme maturation permease component MAG.T1.121_03294 33876.JNXY01000001_gene5627 8.2e-107 393.7 Micromonosporales Bacteria 2GKRH@201174,4D958@85008,COG2141@1,COG2141@2 NA|NA|NA C Luciferase-like monooxygenase MAG.T1.121_03296 479434.Sthe_2641 3.5e-09 68.6 Thermomicrobia Bacteria 27YPH@189775,28SAM@1,2GBPC@200795,2ZEMQ@2 NA|NA|NA MAG.T1.121_03297 1123073.KB899241_gene2268 1.6e-48 199.9 Xanthomonadales Bacteria 1RIRV@1224,1SFXN@1236,1X59H@135614,2ZBM3@2,arCOG08211@1 NA|NA|NA MAG.T1.121_03298 1183438.GKIL_3724 4.7e-18 100.1 Cyanobacteria Bacteria 1G1Q1@1117,COG1506@1,COG1506@2 NA|NA|NA EU PFAM Prolyl oligopeptidase family MAG.T1.121_03299 196162.Noca_1500 4.5e-62 244.6 Propionibacteriales WQ51_05710 Bacteria 2I9XC@201174,4DV9Q@85009,COG2013@1,COG2013@2 NA|NA|NA S Mitochondrial biogenesis AIM24 MAG.T1.121_03301 1303692.SFUL_2062 7.5e-18 96.7 Actinobacteria Bacteria 2A6BC@1,2H9DQ@201174,30V43@2 NA|NA|NA S Protein of unknown function (DUF2834) MAG.T1.121_03302 1125718.HMPREF1318_1271 0.0 1293.5 Actinobacteria Bacteria 2HM3S@201174,4D6AX@85005,COG1204@1,COG1204@2 NA|NA|NA L Helicase conserved C-terminal domain MAG.T1.121_03303 338969.Rfer_0180 1.1e-30 139.4 Comamonadaceae Bacteria 1PWGB@1224,2WC0Y@28216,4AIPC@80864,COG4226@1,COG4226@2 NA|NA|NA S HicB family MAG.T1.121_03304 338969.Rfer_0179 2e-23 114.8 Betaproteobacteria hicA Bacteria 1PXUN@1224,2CT64@1,2VYMM@28216,32SSN@2 NA|NA|NA S HicA toxin of bacterial toxin-antitoxin, MAG.T1.121_03306 1268622.AVS7_02339 1.8e-58 232.6 Betaproteobacteria ko:K07451,ko:K07453 ko00000,ko01000,ko02048 Bacteria 1MZRA@1224,2VWZU@28216,COG3183@1,COG3183@2 NA|NA|NA L HNH nucleases MAG.T1.121_03307 37919.EP51_36815 2.4e-52 212.2 Nocardiaceae ko:K07006 ko00000 Bacteria 2H5HQ@201174,4FVW3@85025,COG3576@1,COG3576@2 NA|NA|NA S Pyridoxamine 5'-phosphate oxidase MAG.T1.121_03308 43759.JNWK01000023_gene5287 2.1e-166 592.4 Actinobacteria Bacteria 2GITS@201174,COG0477@1,COG0477@2 NA|NA|NA EGP Major facilitator Superfamily MAG.T1.121_03309 1122137.AQXF01000001_gene2636 8.6e-12 79.0 Alphaproteobacteria Bacteria 1NT97@1224,2TWGD@28211,COG3391@1,COG3391@2 NA|NA|NA P NHL repeat MAG.T1.121_03310 526227.Mesil_1629 1e-18 99.4 Deinococcus-Thermus Bacteria 1WK2A@1297,COG3293@1,COG3293@2 NA|NA|NA L COG3293 Transposase and inactivated derivatives MAG.T1.121_03311 1121405.dsmv_0002 7.3e-99 367.5 Proteobacteria ko:K21786 ko00333,ko01130,map00333,map01130 M00837,M00838 R11670 ko00000,ko00001,ko00002,ko01000 Bacteria 1QTUH@1224,COG2890@1,COG2890@2 NA|NA|NA J O-methyltransferase MAG.T1.121_03313 1125863.JAFN01000001_gene3139 2.3e-43 183.0 Deltaproteobacteria Bacteria 1PIF4@1224,2WQX1@28221,42UWY@68525,COG0697@1,COG0697@2 NA|NA|NA EG EamA-like transporter family MAG.T1.121_03314 479434.Sthe_0197 3e-99 368.2 Thermomicrobia phnP 2.3.1.181,3.1.4.55 ko:K03801,ko:K06167 ko00440,ko00785,ko01100,map00440,map00785,map01100 R07766,R07769,R10205 RC00039,RC00296,RC00992,RC02867 ko00000,ko00001,ko01000 Bacteria 27Y03@189775,2G8BU@200795,COG1235@1,COG1235@2 NA|NA|NA S Metallo-beta-lactamase superfamily MAG.T1.121_03318 1150469.RSPPHO_00671 3.9e-22 112.1 Rhodospirillales ko:K06217 ko00000 Bacteria 1MWMU@1224,2JPXI@204441,2TSYC@28211,COG1702@1,COG1702@2 NA|NA|NA T COG1702 Phosphate starvation-inducible protein PhoH MAG.T1.121_03319 323098.Nwi_1207 0.0 1075.8 Bradyrhizobiaceae glgB GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033554,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:1901576 2.4.1.18 ko:K00700,ko:K17734 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 ko00000,ko00001,ko00002,ko01000,ko01002,ko04147 CBM48,GH13 iAPECO1_1312.APECO1_3025,iECNA114_1301.ECNA114_3542,iECOK1_1307.ECOK1_3857,iECS88_1305.ECS88_3830,iECSF_1327.ECSF_3253,iLF82_1304.LF82_0837,iNRG857_1313.NRG857_17030,iUTI89_1310.UTI89_C3941 Bacteria 1MVM7@1224,2VF2F@28211,3K6F6@41294,COG0296@1,COG0296@2 NA|NA|NA G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position MAG.T1.121_03320 546274.EIKCOROL_01923 8.4e-07 61.6 Neisseriales Bacteria 1P0BY@1224,2BWD7@1,2KTBX@206351,2W4GG@28216,346A0@2 NA|NA|NA MAG.T1.121_03321 309801.trd_A0613 1.2e-107 396.7 Thermomicrobia ko:K19689 ko00000,ko01000,ko01002 Bacteria 27YZB@189775,2G62B@200795,COG2309@1,COG2309@2 NA|NA|NA E Thermophilic metalloprotease (M29) MAG.T1.121_03322 309801.trd_0598 9.3e-51 207.2 Thermomicrobia Z012_04125 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K15599 ko02010,map02010 M00442 ko00000,ko00001,ko00002,ko02000 3.A.1.17.3,3.A.1.17.6 Bacteria 27ZCZ@189775,2G6R1@200795,COG0600@1,COG0600@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component MAG.T1.121_03323 1278308.KB907080_gene2424 2.4e-63 249.2 Microbacteriaceae tauB ko:K02049,ko:K15600 ko02010,map02010 M00188,M00442 ko00000,ko00001,ko00002,ko02000 3.A.1.16,3.A.1.17,3.A.1.17.3,3.A.1.17.6 Bacteria 2GN33@201174,4FN1U@85023,COG1116@1,COG1116@2 NA|NA|NA P ATPases associated with a variety of cellular activities MAG.T1.121_03328 631362.Thi970DRAFT_00339 2.5e-15 89.0 Chromatiales ko:K07114 ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 Bacteria 1NGZ7@1224,1TK9V@1236,1X0W7@135613,COG0789@1,COG0789@2 NA|NA|NA K helix_turn_helix, mercury resistance MAG.T1.121_03330 269797.Mbar_A2668 6.7e-90 337.8 Methanomicrobia Archaea 2NAJ8@224756,2Y36Z@28890,arCOG05230@1,arCOG05230@2157 NA|NA|NA MAG.T1.121_03332 479434.Sthe_2214 6e-50 203.8 Thermomicrobia prs 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 Bacteria 27Y4E@189775,2G5T8@200795,COG0462@1,COG0462@2 NA|NA|NA F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) MAG.T1.121_03335 1172188.KB911820_gene2087 2.6e-24 118.2 Intrasporangiaceae Bacteria 2FC1J@1,2IHT3@201174,3445K@2,4FGQ8@85021 NA|NA|NA MAG.T1.121_03339 979556.MTES_0239 4.7e-121 440.7 Actinobacteria Bacteria 2BF9K@1,2ISER@201174,3292G@2 NA|NA|NA MAG.T1.121_03341 469383.Cwoe_1948 2.7e-61 242.7 Actinobacteria 1.14.14.5 ko:K04091 ko00920,map00920 R07210,R10206 RC01779,RC02556 ko00000,ko00001,ko01000 Bacteria 2GJ6T@201174,COG2141@1,COG2141@2 NA|NA|NA C F420-dependent oxidoreductase MAG.T1.121_03342 1191523.MROS_2687 7.2e-25 119.8 Bacteria ko:K07461 ko00000 Bacteria COG2827@1,COG2827@2 NA|NA|NA L Endonuclease containing a URI domain MAG.T1.121_03344 266117.Rxyl_0548 2.8e-79 302.0 Rubrobacteria 3.6.3.17 ko:K02056 M00221 ko00000,ko00002,ko01000,ko02000 3.A.1.2 Bacteria 2IC7X@201174,4CPP9@84995,COG1129@1,COG1129@2 NA|NA|NA G ATPases associated with a variety of cellular activities MAG.T1.121_03345 1380350.JIAP01000019_gene20 3.8e-10 70.5 Alphaproteobacteria ko:K02057 M00221 ko00000,ko00002,ko02000 3.A.1.2 Bacteria 1RFHX@1224,2URI4@28211,COG1172@1,COG1172@2 NA|NA|NA G Branched-chain amino acid transport system / permease component MAG.T1.121_03346 309801.trd_A0508 1.2e-87 329.7 Thermomicrobia lplA 6.3.1.20 ko:K03800 ko00785,ko01100,map00785,map01100 R07770,R07771,R11143 RC00043,RC00070,RC00090,RC00992,RC02896 ko00000,ko00001,ko01000 Bacteria 27XM5@189775,2G7JY@200795,COG0095@1,COG0095@2 NA|NA|NA H biotin lipoate A B protein ligase MAG.T1.121_03347 1236902.ANAS01000037_gene5366 8.1e-19 99.8 Streptosporangiales lplA 6.3.1.20 ko:K03800 ko00785,ko01100,map00785,map01100 R07770,R07771,R11143 RC00043,RC00070,RC00090,RC00992,RC02896 ko00000,ko00001,ko01000 Bacteria 2GJV5@201174,4EM73@85012,COG0095@1,COG0095@2 NA|NA|NA H Biotin/lipoate A/B protein ligase family MAG.T1.121_03348 1382306.JNIM01000001_gene3296 2.2e-38 166.0 Chloroflexi hemY Bacteria 2G7T7@200795,COG1232@1,COG1232@2 NA|NA|NA H PFAM amine oxidase MAG.T1.121_03349 1437824.BN940_07871 9.6e-205 719.5 Bacteria Bacteria COG1457@1,COG1457@2 NA|NA|NA F cytosine transport MAG.T1.121_03350 323098.Nwi_1216 1.5e-94 352.1 Bradyrhizobiaceae MA20_25950 Bacteria 1MVMD@1224,2TS4J@28211,3JQN4@41294,COG4663@1,COG4663@2 NA|NA|NA Q Part of the tripartite ATP-independent periplasmic (TRAP) transport system MAG.T1.121_03351 323098.Nwi_1217 1.6e-272 944.9 Bradyrhizobiaceae dctM Bacteria 1R4MZ@1224,2TQNR@28211,3JUDS@41294,COG4664@1,COG4664@2 NA|NA|NA Q TRAP C4-dicarboxylate transport system permease DctM subunit MAG.T1.121_03352 1144275.COCOR_01084 2e-107 396.4 Proteobacteria mcrA Bacteria 1R7PW@1224,COG0277@1,COG0277@2 NA|NA|NA C FAD binding domain MAG.T1.121_03353 383372.Rcas_3842 2.3e-13 81.6 Chloroflexia ko:K02035 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 2G8DD@200795,377K1@32061,COG0747@1,COG0747@2 NA|NA|NA E PFAM extracellular solute-binding protein, family 5 MAG.T1.121_03358 479434.Sthe_3417 9e-17 92.8 Bacteria ko:K19159 ko00000,ko02048 Bacteria COG2161@1,COG2161@2 NA|NA|NA D toxin-antitoxin pair type II binding MAG.T1.121_03360 1445613.JALM01000067_gene5557 8.3e-65 254.2 Bacteria 3.1.1.41 ko:K01060 ko00311,ko01130,map00311,map01130 R03062 RC00020,RC00041 ko00000,ko00001,ko01000 Bacteria COG3458@1,COG3458@2 NA|NA|NA Q cephalosporin-C deacetylase activity MAG.T1.121_03361 1122614.JHZF01000011_gene1192 7.5e-64 250.0 Oceanicola pntA GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008746,GO:0008750,GO:0009117,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016652,GO:0019362,GO:0019637,GO:0031224,GO:0031226,GO:0034641,GO:0036094,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0046483,GO:0046496,GO:0046983,GO:0048037,GO:0050661,GO:0050662,GO:0051186,GO:0051287,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072524,GO:0097159,GO:1901265,GO:1901360,GO:1901363,GO:1901564 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 R00112 RC00001 ko00000,ko00001,ko01000 iEcE24377_1341.EcE24377A_1810 Bacteria 1MVXU@1224,2PC7A@252301,2TSZN@28211,COG3288@1,COG3288@2 NA|NA|NA C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane MAG.T1.121_03362 298654.FraEuI1c_0677 3e-75 288.9 Frankiales msrA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006807,GO:0006950,GO:0006979,GO:0008113,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016667,GO:0016671,GO:0019538,GO:0030091,GO:0033744,GO:0036456,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0055114,GO:0071704,GO:1901564 1.8.4.11 ko:K07304 ko00000,ko01000 iECSE_1348.ECSE_4525 Bacteria 2GJ1S@201174,4ESDQ@85013,COG0225@1,COG0225@2 NA|NA|NA O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine MAG.T1.121_03367 575540.Isop_2442 4e-20 104.4 Bacteria rusA GO:0000217,GO:0000400,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008821,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363 3.1.22.4 ko:K01160 ko00000,ko01000,ko03400 Bacteria COG4570@1,COG4570@2 NA|NA|NA L crossover junction endodeoxyribonuclease activity MAG.T1.121_03368 643562.Daes_1590 1.3e-25 122.9 Desulfovibrionales Bacteria 1R6X9@1224,28JKI@1,2M9A4@213115,2WJ3B@28221,2Z9DC@2,42Q94@68525 NA|NA|NA S Protein of unknown function (DUF669) MAG.T1.121_03369 309801.trd_1376 3.9e-45 188.7 Thermomicrobia rnc GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 Bacteria 27Y8K@189775,2G6PD@200795,COG0571@1,COG0571@2 NA|NA|NA J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism MAG.T1.121_03372 298654.FraEuI1c_4211 2.6e-119 435.3 Actinobacteria Bacteria 2GMUP@201174,COG2141@1,COG2141@2 NA|NA|NA C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases MAG.T1.121_03373 323097.Nham_0920 7.1e-110 403.3 Bradyrhizobiaceae maiA 5.2.1.2,5.2.1.4 ko:K01800,ko:K01801 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R03181,R03868 RC00867 ko00000,ko00001,ko00002,ko01000 Bacteria 1RA4Y@1224,2U5B6@28211,3JS39@41294,COG0625@1,COG0625@2 NA|NA|NA O Glutathione S-transferase, N-terminal domain MAG.T1.121_03374 323097.Nham_0921 1.5e-111 408.7 Bradyrhizobiaceae hmgA GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0003824,GO:0004411,GO:0005488,GO:0005506,GO:0005575,GO:0006082,GO:0006355,GO:0006520,GO:0006558,GO:0006559,GO:0006570,GO:0006572,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0017144,GO:0019219,GO:0019222,GO:0019439,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0042737,GO:0043167,GO:0043169,GO:0043436,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0045892,GO:0045934,GO:0046395,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051213,GO:0051252,GO:0051253,GO:0055114,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0140110,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902221,GO:1902222,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 1.13.11.5 ko:K00451 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R02519 RC00737 ko00000,ko00001,ko00002,ko01000 Bacteria 1MV9G@1224,2TRFI@28211,3JS7Y@41294,COG3508@1,COG3508@2 NA|NA|NA Q Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate MAG.T1.121_03376 1128421.JAGA01000002_gene1243 1.1e-56 226.9 unclassified Bacteria modB ko:K02018 ko02010,map02010 M00189 ko00000,ko00001,ko00002,ko02000 3.A.1.8 Bacteria 2NPSC@2323,COG0555@1,COG0555@2 NA|NA|NA O Binding-protein-dependent transport system inner membrane component MAG.T1.121_03377 448385.sce5265 4.8e-49 201.8 Myxococcales M1-763 Bacteria 1MX4H@1224,2WJ2Y@28221,2YW6C@29,42PY0@68525,COG0491@1,COG0491@2 NA|NA|NA S Metallo-beta-lactamase superfamily MAG.T1.121_03379 331869.BAL199_01644 1.3e-51 209.5 Alphaproteobacteria Bacteria 1MX34@1224,2U0IN@28211,COG0402@1,COG0402@2 NA|NA|NA F COG0402 Cytosine deaminase and related metal-dependent hydrolases MAG.T1.121_03380 1237500.ANBA01000007_gene3076 2.9e-55 221.5 Streptosporangiales soxR ko:K13639 ko00000,ko03000 Bacteria 2GKTU@201174,4EJ4S@85012,COG0789@1,COG0789@2 NA|NA|NA K MerR, DNA binding MAG.T1.121_03381 797302.Halru_2457 9e-09 67.4 Halobacteria Archaea 23V7N@183963,2XWUA@28890,arCOG13437@1,arCOG13437@2157 NA|NA|NA S N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD MAG.T1.121_03383 1037409.BJ6T_13990 1.1e-42 179.5 Bradyrhizobiaceae Bacteria 1N8A5@1224,2VF74@28211,3JYGN@41294,COG1204@1,COG1204@2 NA|NA|NA L DEAD DEAH box helicase MAG.T1.121_03384 1382356.JQMP01000001_gene959 1.2e-91 343.2 Thermomicrobia nikV 3.6.3.24 ko:K02031,ko:K02032,ko:K10823,ko:K10824 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439,M00440 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 27Z3W@189775,2GARG@200795,COG4608@1,COG4608@2 NA|NA|NA P Oligopeptide/dipeptide transporter, C-terminal region MAG.T1.121_03385 1382356.JQMP01000001_gene960 1.3e-52 212.6 Thermomicrobia oppD ko:K02031,ko:K02032 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 27Z2B@189775,2GBE3@200795,COG0444@1,COG0444@2 NA|NA|NA P Oligopeptide/dipeptide transporter, C-terminal region MAG.T1.121_03386 479434.Sthe_2683 7.3e-71 274.2 Thermomicrobia fsr ko:K08223 ko00000,ko02000 2.A.1.35 Bacteria 27Z1P@189775,2GBPV@200795,COG0477@1,COG2814@2 NA|NA|NA EGP Major Facilitator Superfamily MAG.T1.121_03387 357808.RoseRS_2780 2.5e-97 362.1 Chloroflexi Bacteria 2G5QC@200795,COG2141@1,COG2141@2 NA|NA|NA C PFAM Luciferase-like monooxygenase MAG.T1.121_03391 1236902.ANAS01000005_gene4674 4.8e-58 231.1 Streptosporangiales yigZ 2.1.1.45,3.4.13.9 ko:K00560,ko:K01271 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000,ko01002 Bacteria 2GMM4@201174,4EJ1Q@85012,COG1739@1,COG1739@2 NA|NA|NA S Uncharacterized protein family UPF0029 MAG.T1.121_03392 1033730.CAHG01000006_gene1141 5.3e-55 220.7 Propionibacteriales Bacteria 2GPDB@201174,4DSSW@85009,COG3797@1,COG3797@2 NA|NA|NA S Protein of unknown function (DUF1697) MAG.T1.121_03393 314278.NB231_05160 3e-07 61.6 Chromatiales ko:K07063 ko00000 Bacteria 1RE43@1224,1S40R@1236,1WZSU@135613,COG1569@1,COG1569@2 NA|NA|NA S PIN domain MAG.T1.121_03394 479434.Sthe_1282 1.2e-31 142.9 Thermomicrobia wecA GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0034645,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0045229,GO:0046872,GO:0046914,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:1901576 2.7.8.33,2.7.8.35 ko:K02851 R08856 RC00002 ko00000,ko01000,ko01003,ko01005 Bacteria 27Y1S@189775,2G6H5@200795,COG0472@1,COG0472@2 NA|NA|NA M Glycosyl transferase family 4 MAG.T1.121_03396 525904.Tter_1753 6.1e-24 117.1 unclassified Bacteria rsfS GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113 2.7.7.18 ko:K00969,ko:K09710 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000,ko03009 Bacteria 2NPYI@2323,COG0799@1,COG0799@2 NA|NA|NA S Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation MAG.T1.121_03398 926556.Echvi_4281 3.5e-26 124.0 Cytophagia ko:K04750 ko00000 Bacteria 47MD3@768503,4NFVK@976,COG2764@1,COG2764@2,COG3832@1,COG3832@2 NA|NA|NA S Activator of Hsp90 ATPase homolog 1-like protein MAG.T1.121_03399 309801.trd_0049 1.5e-98 366.3 Thermomicrobia cca 2.7.7.19,2.7.7.72 ko:K00970,ko:K00974 ko03013,ko03018,map03013,map03018 R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016,ko03019 Bacteria 27Y1Y@189775,2G6B7@200795,COG0617@1,COG0617@2 NA|NA|NA J Probable RNA and SrmB- binding site of polymerase A MAG.T1.121_03401 1303692.SFUL_1931 4.6e-127 461.5 Actinobacteria Bacteria 2GRDZ@201174,COG5361@1,COG5361@2 NA|NA|NA S Protein of unknown function (DUF1254) MAG.T1.121_03402 1123386.AUIW01000001_gene155 6.4e-69 267.7 Deinococcus-Thermus kynB 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 Bacteria 1WJ7A@1297,COG1878@1,COG1878@2 NA|NA|NA S Putative cyclase MAG.T1.121_03403 1380391.JIAS01000013_gene3688 7.9e-14 84.0 Bacteria Bacteria COG1335@1,COG1335@2 NA|NA|NA Q hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides MAG.T1.121_03404 158500.BV97_03117 2.6e-46 191.0 Sphingomonadales Bacteria 1MXI6@1224,2K191@204457,2TS6X@28211,COG0517@1,COG0517@2 NA|NA|NA S Putative transposase MAG.T1.121_03406 1469613.JT55_13645 7.6e-132 476.9 Rhodovulum ko:K07089 ko00000 Bacteria 1MUN8@1224,2TRU3@28211,3FDK7@34008,COG0701@1,COG0701@2 NA|NA|NA S Predicted permease MAG.T1.121_03407 195105.CN97_04070 2e-22 111.3 Alphaproteobacteria Bacteria 1N728@1224,2UFJA@28211,COG0526@1,COG0526@2 NA|NA|NA CO Thioredoxin domain MAG.T1.121_03408 1122134.KB893650_gene906 1.3e-09 68.2 Oceanospirillales hrtA ko:K02003,ko:K09814 ko02010,map02010 M00257,M00258 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1 Bacteria 1MXVW@1224,1RRZ9@1236,1XNEA@135619,COG1136@1,COG1136@2 NA|NA|NA V ATPases associated with a variety of cellular activities MAG.T1.121_03409 1054213.HMPREF9946_02843 9.3e-29 132.9 Rhodospirillales ko:K02053 ko02024,map02024 M00193 ko00000,ko00001,ko00002,ko02000 3.A.1.11 Bacteria 1MUQD@1224,2JWQU@204441,2U1YB@28211,COG1177@1,COG1177@2 NA|NA|NA E Binding-protein-dependent transport system inner membrane component MAG.T1.121_03410 1156937.MFUM_550026 3.1e-34 151.4 unclassified Verrucomicrobia Bacteria 37GMZ@326457,46ZAV@74201,COG2210@1,COG2210@2 NA|NA|NA S DsrE/DsrF-like family MAG.T1.121_03411 926560.KE387023_gene2054 1.3e-22 112.1 Bacteria Bacteria COG0425@1,COG0425@2 NA|NA|NA O sulfur carrier activity MAG.T1.121_03412 1382306.JNIM01000001_gene588 3.8e-210 737.6 Bacteria xfp 4.1.2.22,4.1.2.9 ko:K01621 ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120 R00761,R01621 RC00032,RC00226 ko00000,ko00001,ko01000 Bacteria COG3957@1,COG3957@2 NA|NA|NA G D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase MAG.T1.121_03414 118005.AWNK01000007_gene737 1.2e-27 129.0 Bacteria ko:K07493 ko00000 Bacteria COG3328@1,COG3328@2 NA|NA|NA L transposase activity MAG.T1.121_03415 1173264.KI913949_gene2028 1.9e-72 280.0 Oscillatoriales Bacteria 1G0M7@1117,1HA8V@1150,COG3385@1,COG3385@2 NA|NA|NA L transposase activity MAG.T1.121_03419 525904.Tter_2571 1.5e-93 349.4 unclassified Bacteria Bacteria 2NQYF@2323,COG0454@1,COG0456@2 NA|NA|NA K Acetyltransferase (GNAT) domain MAG.T1.121_03420 595593.JREV01000045_gene892 1.9e-39 169.5 Actinobacteria ugpQ 3.1.4.46 ko:K01126 ko00564,map00564 R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 Bacteria 2GNM5@201174,COG0584@1,COG0584@2 NA|NA|NA C glycerophosphoryl diester phosphodiesterase MAG.T1.121_03421 479434.Sthe_0440 8.2e-31 139.8 Thermomicrobia hspR GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 ko:K13640 ko00000,ko03000 Bacteria 27YHN@189775,2G72X@200795,COG0789@1,COG0789@2 NA|NA|NA K helix_turn_helix, mercury resistance MAG.T1.121_03422 1003200.AXXA_09413 1.8e-100 372.9 Betaproteobacteria wblG Bacteria 1MWU0@1224,2VNNX@28216,COG0438@1,COG0438@2 NA|NA|NA M Glycosyltransferase Family 4 MAG.T1.121_03424 1382356.JQMP01000001_gene1112 1.4e-07 63.9 Thermomicrobia Bacteria 27Z6N@189775,2GBEQ@200795,COG4454@1,COG4454@2 NA|NA|NA MAG.T1.121_03428 479434.Sthe_0189 2.1e-86 326.2 Bacteria dadA 1.4.5.1 ko:K00285 ko00360,map00360 R01374,R09493 RC00006,RC00025 ko00000,ko00001,ko01000 Bacteria COG0665@1,COG0665@2 NA|NA|NA E tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity MAG.T1.121_03429 1382356.JQMP01000004_gene655 7.9e-157 560.1 Thermomicrobia aldA 1.2.1.3,1.2.1.8 ko:K00128,ko:K00130 ko00010,ko00053,ko00071,ko00260,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00260,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135,M00555 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02565,R02566,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 Bacteria 27XTS@189775,2G5JE@200795,COG1012@1,COG1012@2 NA|NA|NA C Aldehyde dehydrogenase family MAG.T1.121_03431 366602.Caul_1972 1.1e-20 107.1 Bacteria 5.4.2.12 ko:K15634 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 Bacteria COG0406@1,COG0406@2 NA|NA|NA G alpha-ribazole phosphatase activity MAG.T1.121_03432 479434.Sthe_1036 8.1e-66 256.9 Thermomicrobia rplC GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010604,GO:0010628,GO:0015934,GO:0016020,GO:0016043,GO:0019219,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0031323,GO:0031325,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000232,GO:2000234 ko:K02906 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 27XVD@189775,2G6DQ@200795,COG0087@1,COG0087@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit MAG.T1.121_03433 479434.Sthe_1035 3.7e-43 180.6 Thermomicrobia rpsJ GO:0001072,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006355,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0015935,GO:0019219,GO:0019222,GO:0019538,GO:0022626,GO:0022627,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043244,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0140110,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2001141 ko:K02946 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 27YDP@189775,2G6RB@200795,COG0051@1,COG0051@2 NA|NA|NA J Involved in the binding of tRNA to the ribosomes MAG.T1.121_03435 1547437.LL06_18640 1.6e-57 229.2 Phyllobacteriaceae Bacteria 1QUS5@1224,2U5P4@28211,43JX5@69277,COG0454@1,COG0454@2 NA|NA|NA K -acetyltransferase MAG.T1.121_03436 1547437.LL06_18635 1.1e-19 102.4 Phyllobacteriaceae Bacteria 1N85C@1224,2UCYM@28211,43Q41@69277,COG4453@1,COG4453@2 NA|NA|NA S Protein of unknown function (DUF1778) MAG.T1.121_03437 28072.Nos7524_1866 6.8e-33 147.1 Nostocales yfjM Bacteria 1GJBC@1117,1HRBA@1161,COG1479@1,COG1479@2,COG3472@1,COG3472@2 NA|NA|NA S Protein of unknown function DUF262 MAG.T1.121_03439 1510531.JQJJ01000009_gene632 1.3e-115 422.9 Bradyrhizobiaceae moeA 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 R09735 RC03462 ko00000,ko00001,ko01000 Bacteria 1MVD5@1224,2TQRI@28211,3JRT8@41294,COG0303@1,COG0303@2 NA|NA|NA H MoeA C-terminal region (domain IV) MAG.T1.121_03440 1217718.ALOU01000005_gene1521 4.9e-49 201.1 Burkholderiaceae Bacteria 1KH5I@119060,1MUPW@1224,2VNG1@28216,COG0277@1,COG0277@2 NA|NA|NA C Berberine and berberine like MAG.T1.121_03443 479434.Sthe_3071 3.9e-12 77.4 Thermomicrobia Bacteria 27Y7R@189775,2G8CA@200795,COG2141@1,COG2141@2 NA|NA|NA C Luciferase-like monooxygenase MAG.T1.121_03444 1304865.JAGF01000001_gene1075 6.3e-46 190.7 Bacteria 4.1.1.35 ko:K00754,ko:K08678,ko:K13613 ko00520,ko01100,map00520,map01100 M00361 R01384 RC00508 ko00000,ko00001,ko00002,ko01000,ko01004,ko01008 GT4 Bacteria COG0451@1,COG0451@2,COG0457@1,COG0457@2 NA|NA|NA GM ADP-glyceromanno-heptose 6-epimerase activity MAG.T1.121_03447 1304883.KI912532_gene517 5e-118 430.6 Rhodocyclales livG ko:K01995,ko:K01996 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 1MUTY@1224,2KVIX@206389,2VJM6@28216,COG0411@1,COG0411@2 NA|NA|NA E branched-chain amino acid MAG.T1.121_03448 1185652.USDA257_c17190 3.7e-10 70.9 Rhizobiaceae ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 ko00000,ko00001,ko00002,ko02000 3.A.1.1 Bacteria 1MVS0@1224,2TRG2@28211,4BAWB@82115,COG3842@1,COG3842@2 NA|NA|NA E TOBE domain MAG.T1.121_03449 861299.J421_1819 3.7e-11 74.3 Bacteria 1.7.2.1 ko:K00368,ko:K02638 ko00195,ko00910,ko01120,map00195,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko00194,ko01000 Bacteria COG3794@1,COG3794@2 NA|NA|NA C PFAM blue (type 1) copper domain protein MAG.T1.121_03454 1380394.JADL01000001_gene2466 2.5e-32 144.4 Rhodospirillales MA20_13925 ko:K01995 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 1QUC5@1224,2JR1Z@204441,2U1AQ@28211,COG0411@1,COG0411@2 NA|NA|NA E ATPases associated with a variety of cellular activities MAG.T1.121_03456 1298863.AUEP01000009_gene41 4.2e-13 80.5 Propionibacteriales Bacteria 2DN4G@1,2ISQR@201174,32VGH@2,4DVD2@85009 NA|NA|NA MAG.T1.121_03457 371731.Rsw2DRAFT_2634 1.8e-31 142.1 Rhodobacter prmA ko:K02687 ko00000,ko01000,ko03009 Bacteria 1FBB0@1060,1MUPC@1224,2TTP3@28211,COG2264@1,COG2264@2 NA|NA|NA J Ribosomal protein L11 methyltransferase MAG.T1.121_03458 1122223.KB890696_gene273 1.8e-47 195.7 Deinococcus-Thermus sugA GO:0008150,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051704 ko:K02025,ko:K10237,ko:K15771 ko02010,map02010 M00204,M00207,M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.17,3.A.1.1.2 iNJ661.Rv1236 Bacteria 1WI9Z@1297,COG1175@1,COG1175@2 NA|NA|NA G PFAM binding-protein-dependent transport systems inner membrane component MAG.T1.121_03461 686340.Metal_0095 3.4e-28 130.6 Gammaproteobacteria rcnR GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 ko:K21600 ko00000,ko03000 Bacteria 1N6ZN@1224,1S6I2@1236,COG1937@1,COG1937@2 NA|NA|NA S protein conserved in bacteria # 2768 queries scanned # Total time (seconds): 83.0650539398 # Rate: 33.32 q/s