level1 level2 Count Metabolism Metabolic pathways 11.18 Metabolism Biosynthesis of secondary metabolites 4.81 Metabolism Microbial metabolism in diverse environments 3.03 Metabolism Biosynthesis of amino acids 1.94 Metabolism Carbon metabolism 1.66 Metabolism Purine metabolism 1.66 Metabolism Oxidative phosphorylation 1.27 Metabolism Pyrimidine metabolism 1.19 Metabolism Pyruvate metabolism 0.78 Metabolism Fatty acid degradation 0.78 Metabolism Glycolysis / Gluconeogenesis 0.76 Metabolism Cysteine and methionine metabolism 0.66 Metabolism 2-Oxocarboxylic acid metabolism 0.65 Metabolism Glycine, serine and threonine metabolism 0.61 Metabolism Starch and sucrose metabolism 0.61 Cellular Processes Endocytosis 1.23 Cellular Processes Cell cycle - yeast 1.11 Cellular Processes Peroxisome 0.98 Cellular Processes Meiosis - yeast 0.98 Cellular Processes Autophagy - yeast 0.94 Cellular Processes Autophagy - animal 0.57 Cellular Processes Cell cycle 0.55 Cellular Processes Phagosome 0.51 Cellular Processes Regulation of actin cytoskeleton 0.47 Cellular Processes Tight junction 0.47 Cellular Processes Lysosome 0.45 Cellular Processes Mitophagy - yeast 0.41 Cellular Processes Oocyte meiosis 0.39 Cellular Processes Cellular senescence 0.37 Cellular Processes Necroptosis 0.35 Organismal Systems Thermogenesis 1.51 Organismal Systems Retrograde endocannabinoid signaling 0.57 Organismal Systems Longevity regulating pathway - multiple species 0.53 Organismal Systems Insulin signaling pathway 0.43 Organismal Systems Fc gamma R-mediated phagocytosis 0.41 Organismal Systems PPAR signaling pathway 0.41 Organismal Systems Synaptic vesicle cycle 0.39 Organismal Systems Oxytocin signaling pathway 0.29 Organismal Systems Longevity regulating pathway - worm 0.27 Organismal Systems Estrogen signaling pathway 0.27 Organismal Systems Thyroid hormone signaling pathway 0.27 Organismal Systems Cardiac muscle contraction 0.27 Organismal Systems Chemokine signaling pathway 0.25 Organismal Systems NOD-like receptor signaling pathway 0.25 Organismal Systems Glucagon signaling pathway 0.25 Genetic Information Processing Ribosome 1.84 Genetic Information Processing Protein processing in endoplasmic reticulum 1.37 Genetic Information Processing RNA transport 1.13 Genetic Information Processing Ribosome biogenesis in eukaryotes 1.08 Genetic Information Processing Spliceosome 0.96 Genetic Information Processing RNA degradation 0.74 Genetic Information Processing Aminoacyl-tRNA biosynthesis 0.7 Genetic Information Processing mRNA surveillance pathway 0.68 Genetic Information Processing DNA replication 0.66 Genetic Information Processing Nucleotide excision repair 0.63 Genetic Information Processing Proteasome 0.61 Genetic Information Processing Ubiquitin mediated proteolysis 0.57 Genetic Information Processing Basal transcription factors 0.51 Genetic Information Processing RNA polymerase 0.45 Genetic Information Processing Homologous recombination 0.37 Environmental Information Processing MAPK signaling pathway - yeast 1.25 Environmental Information Processing mTOR signaling pathway 0.63 Environmental Information Processing AMPK signaling pathway 0.43 Environmental Information Processing PI3K-Akt signaling pathway 0.37 Environmental Information Processing MAPK signaling pathway 0.35 Environmental Information Processing Sphingolipid signaling pathway 0.35 Environmental Information Processing ABC transporters 0.31 Environmental Information Processing cAMP signaling pathway 0.31 Environmental Information Processing Ras signaling pathway 0.29 Environmental Information Processing Apelin signaling pathway 0.29 Environmental Information Processing HIF-1 signaling pathway 0.27 Environmental Information Processing FoxO signaling pathway 0.27 Environmental Information Processing Phosphatidylinositol signaling system 0.25 Environmental Information Processing Phospholipase D signaling pathway 0.23 Environmental Information Processing Rap1 signaling pathway 0.22