# emapper version: emapper-hotfix-numpy-69-gdd722db emapper DB: 2.0 # command: ./emapper.py -m diamond --seed_ortholog_evalue 0.00001 --data_dir /home/bayegy/Databases/emapper/data_dir2.0.1/ --cpu 30 --temp_dir /media/bayegy/disk2/bayegy/pipeline_demos/binning/share3/Bin_all/emapper//MAG.T12.14/_tmp -i /media/bayegy/disk2/bayegy/pipeline_demos/binning/share3/Bin_all/Bin_prokka//MAG.T12.14/MAG.T12.14.faa -o /media/bayegy/disk2/bayegy/pipeline_demos/binning/share3/Bin_all/emapper//MAG.T12.14/MAG.T12.14 --usemem --override # time: Fri Aug 21 04:10:00 2026 #query_name seed_eggNOG_ortholog seed_ortholog_evalue seed_ortholog_score best_tax_level Preferred_name GOs EC KEGG_ko KEGG_Pathway KEGG_Module KEGG_Reaction KEGG_rclass BRITE KEGG_TC CAZy BiGG_Reaction taxonomic scope eggNOG OGs best eggNOG OG COG Functional cat. eggNOG free text desc. MAG.T12.14_00001 2045.KR76_01335 5.4e-56 224.2 Propionibacteriales ko:K03088 ko00000,ko03021 Bacteria 2GJUI@201174,4DR64@85009,COG1595@1,COG1595@2 NA|NA|NA K Sigma-70 region 2 MAG.T12.14_00002 477641.MODMU_2499 2.6e-18 98.6 Frankiales Bacteria 2E61P@1,2II66@201174,330QX@2,4ETM0@85013 NA|NA|NA MAG.T12.14_00003 110319.CF8_3504 8e-119 434.1 Propionibacteriales 3.4.21.62 ko:K01342 ko02024,map02024 ko00000,ko00001,ko01000,ko01002,ko03110 Bacteria 2GNIX@201174,4DPVM@85009,COG1404@1,COG1404@2 NA|NA|NA O peptidase S8 and S53, subtilisin, kexin, sedolisin MAG.T12.14_00004 479435.Kfla_4186 8.7e-157 561.2 Propionibacteriales Bacteria 2GKCX@201174,4DPXK@85009,COG0457@1,COG0457@2,COG4995@1,COG4995@2 NA|NA|NA K CHAT domain MAG.T12.14_00006 390989.JOEG01000003_gene4476 3e-49 202.6 Micromonosporales Bacteria 2HSM4@201174,4DFKR@85008,COG1295@1,COG1295@2 NA|NA|NA S Virulence factor BrkB MAG.T12.14_00008 1121272.KB903290_gene4457 7.7e-09 65.5 Micromonosporales Bacteria 2EI4A@1,2GX45@201174,33BVN@2,4DGEI@85008 NA|NA|NA MAG.T12.14_00009 710696.Intca_3045 6.7e-98 364.8 Intrasporangiaceae Bacteria 2GNPG@201174,4FJ4K@85021,COG0438@1,COG0438@2 NA|NA|NA M Glycosyl transferase MAG.T12.14_00010 345341.KUTG_02430 6.9e-32 143.7 Actinobacteria Bacteria 2I5YD@201174,COG1331@1,COG1331@2 NA|NA|NA O Highly conserved protein containing a thioredoxin domain MAG.T12.14_00011 345341.KUTG_02431 2.1e-128 466.1 Pseudonocardiales Bacteria 2HNS8@201174,4EA2Q@85010,COG2152@1,COG2152@2 NA|NA|NA G beta-1,4-mannooligosaccharide phosphorylase MAG.T12.14_00014 1050202.KB913024_gene1971 2e-50 207.2 Actinopolysporales sigB GO:0000988,GO:0000990,GO:0003674,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0043620,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141 ko:K03090 ko00000,ko03021 Bacteria 2GKSY@201174,407GP@622450,COG1191@1,COG1191@2 NA|NA|NA K Sigma-70 region 3 MAG.T12.14_00016 500153.JOEK01000009_gene5174 5.5e-55 221.5 Actinobacteria rfaF ko:K02843 ko00540,ko01100,map00540,map01100 M00080 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 GT9 Bacteria 2GMZG@201174,COG0859@1,COG0859@2 NA|NA|NA M PFAM glycosyl transferase family 9 MAG.T12.14_00017 47839.CCAU010000009_gene1334 3.9e-33 147.5 Mycobacteriaceae Bacteria 23A2K@1762,2IC9E@201174,COG2105@1,COG2105@2 NA|NA|NA S Gamma-glutamyl cyclotransferase, AIG2-like MAG.T12.14_00018 512565.AMIS_58000 1.6e-49 202.6 Micromonosporales Bacteria 2HF5Y@201174,4DIXE@85008,COG5592@1,COG5592@2 NA|NA|NA S Hemerythrin HHE cation binding domain MAG.T12.14_00019 356851.JOAN01000011_gene5380 2.3e-68 266.2 Micromonosporales sod22 Bacteria 2GKCK@201174,4DAWY@85008,COG0025@1,COG0025@2 NA|NA|NA P Sodium/hydrogen exchanger family MAG.T12.14_00020 1246995.AFR_23530 1e-53 216.1 Micromonosporales Bacteria 2IM3K@201174,4DEGD@85008,COG0517@1,COG0517@2 NA|NA|NA S CBS domain MAG.T12.14_00022 28444.JODQ01000004_gene6201 6.2e-37 161.4 Streptosporangiales ubiA Bacteria 2GJT3@201174,4ENNX@85012,COG0382@1,COG0382@2 NA|NA|NA H UbiA prenyltransferase family MAG.T12.14_00023 105425.BBPL01000030_gene4521 7.7e-90 337.4 Streptacidiphilus srsC Bacteria 2GM2M@201174,2NGSA@228398,COG0644@1,COG0644@2 NA|NA|NA C FAD dependent oxidoreductase MAG.T12.14_00024 67281.JNZZ01000019_gene123 3.3e-49 201.4 Streptomyces griseus group ypbQ ko:K16168 ko00000,ko01008 Bacteria 2IG52@201174,41AR5@629295,COG1755@1,COG1755@2 NA|NA|NA S Isoprenylcysteine carboxyl methyltransferase (ICMT) family MAG.T12.14_00025 1463857.JOFZ01000004_gene2858 1.8e-118 432.6 Actinobacteria bcsA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006629,GO:0006725,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009273,GO:0009698,GO:0009699,GO:0009714,GO:0009715,GO:0009987,GO:0016020,GO:0016043,GO:0019438,GO:0019748,GO:0022607,GO:0032991,GO:0034081,GO:0042180,GO:0042181,GO:0042546,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0071554,GO:0071704,GO:0071766,GO:0071770,GO:0071840,GO:0071944,GO:1901360,GO:1901362,GO:1901576 ko:K16167 ko00000,ko01008 Bacteria 2GV0U@201174,COG3424@1,COG3424@2 NA|NA|NA Q synthase MAG.T12.14_00026 1068978.AMETH_3959 6.6e-108 397.1 Pseudonocardiales egtC 3.5.1.118 ko:K07008 ko00340,map00340 R11021 RC00064,RC00090 ko00000,ko00001,ko01000 Bacteria 2GXCD@201174,4DX4A@85010,COG0121@1,COG0121@2 NA|NA|NA S Glutamine amidotransferases class-II MAG.T12.14_00027 471852.Tcur_0543 1.9e-26 127.1 Streptosporangiales Bacteria 2HCHA@201174,4EFUK@85012,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily MAG.T12.14_00028 164757.Mjls_1687 1.4e-23 116.3 Mycobacteriaceae Bacteria 23A9W@1762,2DZHZ@1,2IN6I@201174,31ZDG@2 NA|NA|NA MAG.T12.14_00029 1242864.D187_006584 1.1e-27 131.3 Proteobacteria cmk 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 1R72B@1224,COG0204@1,COG0204@2 NA|NA|NA I COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase MAG.T12.14_00031 926569.ANT_03930 9.1e-66 256.9 Chloroflexi cysE GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009001,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 iJN746.PP_0840 Bacteria 2G6DI@200795,COG1045@1,COG1045@2 NA|NA|NA E TIGRFAM serine O-acetyltransferase MAG.T12.14_00032 243233.MCA1022 9e-130 469.9 Methylococcales cysK GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUBE@1224,1RN6J@1236,1XDN6@135618,COG0031@1,COG0031@2 NA|NA|NA H Belongs to the cysteine synthase cystathionine beta- synthase family MAG.T12.14_00033 1032480.MLP_32170 8.3e-07 60.5 Bacteria ko:K03668,ko:K09914 ko00000 Bacteria COG3187@1,COG3187@2 NA|NA|NA O response to heat MAG.T12.14_00034 1206731.BAGB01000164_gene4329 4.2e-61 241.5 Nocardiaceae Bacteria 2GM3I@201174,4G8PP@85025,COG1028@1,COG1028@2 NA|NA|NA IQ KR domain MAG.T12.14_00035 369723.Strop_2938 1.3e-14 87.4 Micromonosporales ywiC Bacteria 28NT3@1,2IIC3@201174,2ZBRV@2,4DD9K@85008 NA|NA|NA S YwiC-like protein MAG.T12.14_00036 882086.SacxiDRAFT_2995 2.1e-20 105.9 Pseudonocardiales Bacteria 2CK3K@1,2IQJH@201174,32SBH@2,4E5Q5@85010 NA|NA|NA S PFAM Ion channel MAG.T12.14_00037 1463909.KL585974_gene2013 1.8e-30 139.8 Actinobacteria 5.4.99.28,5.4.99.29 ko:K06177,ko:K07052 ko00000,ko01000,ko03009,ko03016 Bacteria 2GKRA@201174,COG1266@1,COG1266@2 NA|NA|NA S Abortive infection protein MAG.T12.14_00038 1352941.M877_24670 5.5e-75 287.7 Actinobacteria cbiQ ko:K02006,ko:K02008 ko02010,map02010 M00245,M00246 ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 Bacteria 2GKQ7@201174,COG0619@1,COG0619@2 NA|NA|NA P Cobalt ABC transporter MAG.T12.14_00039 253839.SSNG_02891 2.3e-103 382.1 Actinobacteria cbiO ko:K02006,ko:K02008 ko02010,map02010 M00245,M00246 ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 Bacteria 2GJ0M@201174,COG1122@1,COG1122@2 NA|NA|NA P part of an ABC transporter complex. Responsible for energy coupling to the transport system MAG.T12.14_00041 1123320.KB889698_gene9298 2.4e-38 165.2 Actinobacteria Bacteria 2GP6A@201174,COG1846@1,COG1846@2 NA|NA|NA K transcriptional regulator MAG.T12.14_00042 68194.JNXR01000024_gene1245 3.9e-124 451.1 Actinobacteria map GO:0000096,GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0006082,GO:0006464,GO:0006508,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009066,GO:0009987,GO:0010467,GO:0016151,GO:0016485,GO:0016787,GO:0019538,GO:0019752,GO:0030145,GO:0035551,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0046872,GO:0046914,GO:0050897,GO:0051604,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0140096,GO:1901564,GO:1901605 3.4.11.18 ko:K01265 ko00000,ko01000,ko01002 Bacteria 2GKIZ@201174,COG0024@1,COG0024@2 NA|NA|NA E Methionine aminopeptidase MAG.T12.14_00043 1122609.AUGT01000001_gene2813 3.9e-13 80.1 Propionibacteriales Bacteria 2EHMB@1,2I3MM@201174,33BD3@2,4DS27@85009 NA|NA|NA MAG.T12.14_00044 1122611.KB903988_gene7185 2.5e-110 405.2 Streptosporangiales panB 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJP6@201174,4EGTN@85012,COG0413@1,COG0413@2 NA|NA|NA H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate MAG.T12.14_00045 1122137.AQXF01000003_gene2222 1.9e-35 156.4 Alphaproteobacteria yokD 2.3.1.81 ko:K00662 ko00000,ko01000,ko01504 Bacteria 1R68C@1224,2U1PM@28211,COG2746@1,COG2746@2 NA|NA|NA V aminoglycoside MAG.T12.14_00046 1048339.KB913029_gene4683 9.2e-221 773.1 Frankiales nadE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5,6.3.5.1 ko:K01916,ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00189,R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 Bacteria 2GK2C@201174,4ESAT@85013,COG0171@1,COG0171@2,COG0388@1,COG0388@2 NA|NA|NA H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source MAG.T12.14_00047 1120950.KB892707_gene4731 9.6e-218 762.7 Propionibacteriales glnA2 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0044464,GO:0050001,GO:0071944 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 Bacteria 2GJ2I@201174,4DNNP@85009,COG0174@1,COG0174@2 NA|NA|NA E glutamine synthetase MAG.T12.14_00048 1003195.SCAT_1341 0.0 1078.9 Actinobacteria glnE GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0030312,GO:0031323,GO:0033238,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0060359,GO:0062012,GO:0065007,GO:0070566,GO:0071944,GO:0080090,GO:1901698 2.7.7.42,2.7.7.89 ko:K00982 ko00000,ko01000 Bacteria 2GJ91@201174,COG1391@1,COG1391@2 NA|NA|NA OT Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell MAG.T12.14_00049 1033730.CAHG01000015_gene760 0.0 2077.8 Propionibacteriales fas 2.3.1.179 ko:K09458,ko:K11533 ko00061,ko00780,ko01100,ko01212,ko04931,map00061,map00780,map01100,map01212,map04931 M00082,M00083,M00572 R01624,R01626,R04355,R04428,R04429,R04533,R04534,R04535,R04536,R04537,R04543,R04544,R04566,R04568,R04724,R04726,R04952,R04953,R04954,R04955,R04957,R04958,R04960,R04961,R04963,R04964,R04965,R04966,R04968,R04969,R07762,R07763,R07764,R07765,R10115,R10119,R10700 RC00004,RC00029,RC00039,RC00052,RC00076,RC00117,RC00831,RC01095,RC02727,RC02728,RC02729,RC02857,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 2GIY4@201174,4DN2J@85009,COG0304@1,COG0304@2,COG0331@1,COG0331@2,COG2030@1,COG2030@2,COG4981@1,COG4981@2 NA|NA|NA I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP MAG.T12.14_00050 1078020.KEK_17748 6e-25 120.6 Mycobacteriaceae acpS GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008897,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016780,GO:0018070,GO:0018193,GO:0018209,GO:0018215,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576 2.7.8.7,3.2.1.52 ko:K00997,ko:K01207 ko00520,ko00531,ko00770,ko01100,ko01501,map00520,map00531,map00770,map01100,map01501 M00628 R00022,R01625,R05963,R07809,R07810,R10831 RC00002,RC00049 ko00000,ko00001,ko00002,ko01000 Bacteria 238KS@1762,2IQF6@201174,COG0736@1,COG0736@2 NA|NA|NA I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein MAG.T12.14_00051 585531.HMPREF0063_11333 1.5e-43 183.0 Propionibacteriales Bacteria 2IDJT@201174,4DSNS@85009,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family MAG.T12.14_00052 33898.JRHJ01000025_gene6653 4e-26 126.7 Actinobacteria Bacteria 2GXEC@201174,COG0739@1,COG0739@2 NA|NA|NA M peptidase MAG.T12.14_00053 266940.Krad_4341 1e-138 500.7 Actinobacteria mrcB 2.4.1.129,3.4.16.4 ko:K05365,ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 GT51 Bacteria 2GK21@201174,COG0744@1,COG0744@2 NA|NA|NA M penicillin-binding protein MAG.T12.14_00054 219305.MCAG_01801 2e-48 199.1 Micromonosporales apl 3.1.3.1 ko:K01077 ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020 M00126 R02135,R04620 RC00017 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 Bacteria 2GN43@201174,4D91R@85008,COG0586@1,COG0586@2 NA|NA|NA S SNARE associated Golgi protein MAG.T12.14_00055 1237500.ANBA01000009_gene1397 2.5e-67 262.3 Streptosporangiales ko:K09816 ko02010,map02010 M00242 ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 Bacteria 2GJ7H@201174,4EI6R@85012,COG1108@1,COG1108@2 NA|NA|NA P ABC 3 transport family MAG.T12.14_00056 935866.JAER01000041_gene3044 1.2e-58 233.4 Propionibacteriales mntB ko:K09817 ko02010,map02010 M00242 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.15.3,3.A.1.15.5 Bacteria 2GP3A@201174,4DPIC@85009,COG1121@1,COG1121@2 NA|NA|NA P ATPases associated with a variety of cellular activities MAG.T12.14_00057 1120936.KB907220_gene1908 7.3e-57 227.6 Streptosporangiales scbA ko:K09815 ko02010,map02010 M00242 ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 Bacteria 2GM1K@201174,4EHVW@85012,COG0803@1,COG0803@2 NA|NA|NA P Zinc-uptake complex component A periplasmic MAG.T12.14_00058 1348663.KCH_26840 1.3e-36 159.1 Kitasatospora zur GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010043,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0046872,GO:0046914,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 ko:K02076,ko:K03711,ko:K09823 ko02024,map02024 ko00000,ko00001,ko03000 Bacteria 2IKS3@201174,2M2R1@2063,COG0735@1,COG0735@2 NA|NA|NA P Ferric uptake regulator family MAG.T12.14_00059 1304865.JAGF01000001_gene318 4.3e-172 611.3 Cellulomonadaceae Bacteria 2GIUM@201174,4F1U8@85016,COG0477@1,COG0477@2 NA|NA|NA EGP Transmembrane secretion effector MAG.T12.14_00060 1121934.AUDX01000004_gene2657 2.8e-36 158.7 Microbacteriaceae Bacteria 2GX8K@201174,4FQPR@85023,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family MAG.T12.14_00061 1003195.SCAT_5254 3.5e-107 395.6 Actinobacteria Bacteria 2GIV9@201174,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor MAG.T12.14_00062 1048339.KB913029_gene2698 4.1e-93 347.8 Frankiales Bacteria 2GIZB@201174,4ERW3@85013,COG0745@1,COG0745@2 NA|NA|NA T response regulator MAG.T12.14_00063 235985.BBPN01000004_gene3111 5.5e-16 89.7 Streptacidiphilus ko:K05337 ko00000 Bacteria 2GSJ7@201174,2NJW1@228398,COG1141@1,COG1141@2 NA|NA|NA C 4Fe-4S single cluster domain MAG.T12.14_00064 436229.JOEH01000022_gene682 5.9e-111 407.9 Streptacidiphilus nuoF2 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2GNN9@201174,2NGPM@228398,COG1894@1,COG1894@2 NA|NA|NA C NADH-ubiquinone oxidoreductase-F iron-sulfur binding region MAG.T12.14_00065 106370.Francci3_2586 1.8e-42 179.5 Frankiales ko:K17247 ko00000 Bacteria 2GQH2@201174,4EW08@85013,COG4097@1,COG4097@2 NA|NA|NA P PFAM Ferric reductase domain protein transmembrane component domain MAG.T12.14_00066 105422.BBPM01000049_gene1445 9.5e-69 267.3 Streptacidiphilus apbE 2.7.1.180 ko:K03734 ko00000,ko01000 Bacteria 2H74Y@201174,2NGV9@228398,COG1477@1,COG1477@2 NA|NA|NA H ApbE family MAG.T12.14_00068 382245.ASA_0486 9e-51 206.8 Aeromonadales maa 2.3.1.79 ko:K00661 ko00000,ko01000 Bacteria 1RA2T@1224,1S3ZZ@1236,1Y4GY@135624,COG0110@1,COG0110@2 NA|NA|NA S Maltose acetyltransferase MAG.T12.14_00071 263358.VAB18032_21750 1.9e-25 123.6 Actinobacteria Bacteria 2GRFR@201174,COG3409@1,COG3409@2 NA|NA|NA M PFAM Peptidoglycan-binding domain 1 protein MAG.T12.14_00072 196162.Noca_0300 1.6e-31 142.1 Propionibacteriales Bacteria 2IKJX@201174,32SQA@2,4DR6N@85009,COG5450@1 NA|NA|NA K Transcription regulator of the Arc MetJ class MAG.T12.14_00073 1172185.KB911513_gene4762 6.1e-48 197.2 Nocardiaceae ko:K21429 ko00000,ko01002 Bacteria 2GKWI@201174,4G7P5@85025,COG4894@1,COG4894@2 NA|NA|NA S LURP-one-related MAG.T12.14_00074 1121382.JQKG01000029_gene2690 3.3e-58 231.9 Bacteria 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 Bacteria COG1091@1,COG1091@2 NA|NA|NA M dTDP-4-dehydrorhamnose reductase activity MAG.T12.14_00075 1095767.CAHD01000163_gene3000 5.2e-48 198.0 Actinobacteria Bacteria 2INQ3@201174,COG4122@1,COG4122@2 NA|NA|NA S Methyltransferase domain MAG.T12.14_00076 909613.UO65_4713 1.3e-33 150.6 Pseudonocardiales mprF ko:K07027 ko00000,ko02000 4.D.2 Bacteria 2IC25@201174,4E1XV@85010,COG0392@1,COG0392@2 NA|NA|NA S Lysylphosphatidylglycerol synthase TM region MAG.T12.14_00077 469383.Cwoe_3710 4.6e-84 318.2 Rubrobacteria Bacteria 2I2PK@201174,4CPE1@84995,COG1215@1,COG1215@2 NA|NA|NA M Glycosyl transferase family 2 MAG.T12.14_00078 1380354.JIAN01000006_gene1134 3.8e-117 429.1 Actinobacteria Bacteria 2IF8Q@201174,COG1287@1,COG1287@2 NA|NA|NA S oligosaccharyl transferase activity MAG.T12.14_00079 1304865.JAGF01000001_gene1494 2.3e-33 148.3 Actinobacteria Bacteria 2IKRD@201174,COG3795@1,COG3795@2 NA|NA|NA S PFAM YCII-related MAG.T12.14_00080 287986.DV20_29020 6.4e-23 113.6 Pseudonocardiales Bacteria 2IKRD@201174,4E51J@85010,COG3795@1,COG3795@2 NA|NA|NA S YCII-related domain MAG.T12.14_00081 1380393.JHVP01000006_gene4003 6.3e-126 457.6 Frankiales ko:K03088 ko00000,ko03021 Bacteria 2GJ36@201174,4ES50@85013,COG4941@1,COG4941@2 NA|NA|NA K TIGRFAM RNA polymerase sigma factor, sigma-70 family MAG.T12.14_00083 357809.Cphy_2216 7.3e-23 114.8 Lachnoclostridium ko:K07452,ko:K09384 ko00000,ko01000,ko02048 Bacteria 1U8TV@1239,223CF@1506553,258B5@186801,COG0470@1,COG0470@2 NA|NA|NA L DNA polymerase III MAG.T12.14_00085 1283283.ATXA01000001_gene544 8e-35 153.7 Frankiales Bacteria 2IN6K@201174,4ETDQ@85013,COG1714@1,COG1714@2 NA|NA|NA S RDD family MAG.T12.14_00086 471852.Tcur_2987 1.8e-117 429.5 Streptosporangiales 1.11.1.19 ko:K15733 ko00000,ko01000 Bacteria 2GIUB@201174,4EICS@85012,COG2837@1,COG2837@2 NA|NA|NA P Dyp-type peroxidase family MAG.T12.14_00087 749414.SBI_01457 4.3e-37 161.8 Actinobacteria ycgQ ko:K08986 ko00000 Bacteria 2GZEU@201174,COG3689@1,COG3689@2 NA|NA|NA S TIGRFAM TIGR03943 family protein MAG.T12.14_00088 1463881.KL591026_gene2615 3.9e-63 248.1 Actinobacteria ycgR ko:K07089 ko00000 Bacteria 2GJQ0@201174,COG0701@1,COG0701@2 NA|NA|NA P permease MAG.T12.14_00089 1463887.KL589971_gene4547 2.5e-15 88.2 Actinobacteria ycgR ko:K07089 ko00000 Bacteria 2GJQ0@201174,COG0701@1,COG0701@2 NA|NA|NA P permease MAG.T12.14_00090 350058.Mvan_3810 4.7e-310 1070.5 Mycobacteriaceae pacL2 3.6.3.8 ko:K01537 ko00000,ko01000 3.A.3.2 Bacteria 232MQ@1762,2GJJC@201174,COG0474@1,COG0474@2 NA|NA|NA P ATPase, P-type (transporting), HAD superfamily, subfamily IC MAG.T12.14_00092 1184609.KILIM_066_00310 1.6e-81 308.9 Dermatophilaceae Bacteria 2GY1D@201174,4F7U4@85018,COG0454@1,COG0456@2 NA|NA|NA K Acetyltransferase (GNAT) family MAG.T12.14_00093 196162.Noca_1250 2.9e-18 98.2 Propionibacteriales pccA 2.1.3.1,6.4.1.3 ko:K01965,ko:K17490 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R00353,R01859 RC00040,RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 Bacteria 2GPU3@201174,4DVQ9@85009,COG4770@1,COG4770@2 NA|NA|NA I Biotin-lipoyl like MAG.T12.14_00094 196162.Noca_1249 3.6e-15 87.4 Propionibacteriales 2.1.3.1 ko:K17489 ko00640,map00640 R00353 RC00040 ko00000,ko00001,ko01000 Bacteria 2EJZC@1,2GYHI@201174,33DPX@2,4DW75@85009 NA|NA|NA MAG.T12.14_00095 196162.Noca_1248 1.1e-236 825.9 Propionibacteriales mmdA 2.1.3.1,2.1.3.15,6.4.1.2,6.4.1.3,6.4.1.4 ko:K01966,ko:K01969,ko:K17489,ko:K18472 ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212 M00036,M00082,M00373,M00741 R00353,R00742,R01859,R04138,R04386 RC00040,RC00097,RC00253,RC00367,RC00609,RC00942 ko00000,ko00001,ko00002,ko01000 iLJ478.TM0716 Bacteria 2GIRU@201174,4DU79@85009,COG4799@1,COG4799@2 NA|NA|NA I Malonate decarboxylase gamma subunit (MdcE) MAG.T12.14_00096 196162.Noca_1247 9.6e-238 829.3 Propionibacteriales oadA 2.1.3.1,4.1.1.3,6.4.1.1 ko:K01571,ko:K01960,ko:K03416 ko00020,ko00620,ko00640,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00640,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00217,R00344,R00353,R00930 RC00040,RC00097,RC00367 ko00000,ko00001,ko00002,ko01000,ko02000 3.B.1.1.1 iLJ478.TM0128 Bacteria 2IASR@201174,4DWP1@85009,COG5016@1,COG5016@2 NA|NA|NA C Conserved carboxylase domain MAG.T12.14_00097 1123320.KB889686_gene650 1.3e-36 159.5 Actinobacteria mgsA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0008150,GO:0008152,GO:0008929,GO:0009058,GO:0009438,GO:0009987,GO:0016829,GO:0016835,GO:0016838,GO:0019242,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0071704,GO:1901576 4.2.3.3 ko:K01734 ko00640,ko01120,map00640,map01120 R01016 RC00424 ko00000,ko00001,ko01000 iECUMN_1333.ECUMN_1153,iYL1228.KPN_00992 Bacteria 2IMPC@201174,COG1803@1,COG1803@2 NA|NA|NA G MGS-like domain MAG.T12.14_00098 1404245.CGLY_03165 7.4e-29 134.0 Corynebacteriaceae Bacteria 22JPX@1653,2GKFS@201174,COG0745@1,COG0745@2 NA|NA|NA T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain MAG.T12.14_00099 313589.JNB_07719 9.1e-94 350.1 Intrasporangiaceae fmt2 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 Bacteria 2GKJH@201174,4FEFV@85021,COG1611@1,COG1611@2 NA|NA|NA S Belongs to the LOG family MAG.T12.14_00100 1906.SFRA_16445 3.4e-25 122.1 Actinobacteria 2.7.7.87 ko:K07566 R10463 RC00745 ko00000,ko01000,ko03009,ko03016 Bacteria 2IKIN@201174,COG4902@1,COG4902@2 NA|NA|NA S Uncharacterized protein domain (DUF2202) MAG.T12.14_00101 1035308.AQYY01000002_gene880 9.2e-83 314.3 Clostridia 2.7.13.3 ko:K02484,ko:K07768 ko02020,map02020 M00443 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 1TQ1H@1239,247VG@186801,COG5002@1,COG5002@2 NA|NA|NA T Histidine kinase MAG.T12.14_00102 1035308.AQYY01000002_gene879 1.6e-74 285.8 Clostridia Bacteria 1TS81@1239,248XH@186801,COG0745@1,COG0745@2 NA|NA|NA T response regulator receiver MAG.T12.14_00104 1035308.AQYY01000001_gene3237 1.1e-195 689.5 Clostridia 1.8.5.4 ko:K17218 ko00920,map00920 R10152 RC03155 ko00000,ko00001,ko01000 Bacteria 1V11U@1239,25BW0@186801,COG0446@1,COG0446@2 NA|NA|NA S Pyridine nucleotide-disulphide oxidoreductase MAG.T12.14_00105 1304865.JAGF01000001_gene3278 0.0 1120.1 Cellulomonadaceae cdr ko:K04085 ko04122,map04122 ko00000,ko00001,ko01000,ko03016 Bacteria 2H7WY@201174,4F10M@85016,COG0446@1,COG0446@2,COG0607@1,COG0607@2,COG2210@1,COG2210@2 NA|NA|NA P PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase MAG.T12.14_00106 1051632.TPY_2536 1.7e-22 112.1 Firmicutes Bacteria 1W45F@1239,COG1433@1,COG1433@2 NA|NA|NA S Dinitrogenase iron-molybdenum cofactor MAG.T12.14_00107 1035308.AQYY01000002_gene111 1.7e-58 233.4 Peptococcaceae Bacteria 1V0ES@1239,24Q6Z@186801,26717@186807,COG1275@1,COG1275@2 NA|NA|NA P Voltage-dependent anion channel MAG.T12.14_00108 446469.Sked_03560 1.4e-118 433.3 Actinobacteria phoA 3.1.3.1 ko:K01077 ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020 M00126 R02135,R04620 RC00017 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 Bacteria 2GM8A@201174,COG1785@1,COG1785@2 NA|NA|NA P Belongs to the alkaline phosphatase family MAG.T12.14_00109 1064537.AGSO01000003_gene1096 8.1e-29 134.4 Dermabacteraceae ko:K07090 ko00000 Bacteria 2I5VT@201174,4FCQ5@85020,COG0730@1,COG0730@2 NA|NA|NA S Sulfite exporter TauE/SafE MAG.T12.14_00110 55952.BU52_25740 9.3e-134 483.8 Actinobacteria 3.1.2.6 ko:K01069 ko00620,map00620 R01736 RC00004,RC00137 ko00000,ko00001,ko01000 Bacteria 2GN50@201174,COG0491@1,COG0491@2,COG0607@1,COG0607@2 NA|NA|NA P PFAM beta-lactamase domain protein MAG.T12.14_00111 1123309.AQYB01000031_gene361 3.7e-19 100.9 Bacilli pspE Bacteria 1VES3@1239,4HNRE@91061,COG0607@1,COG0607@2 NA|NA|NA P COG0607 Rhodanese-related sulfurtransferase MAG.T12.14_00114 1121946.AUAX01000005_gene5377 1.2e-207 729.6 Micromonosporales csdA 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 Bacteria 2GP7W@201174,4DAKS@85008,COG0520@1,COG0520@2 NA|NA|NA E Aminotransferase class-V MAG.T12.14_00115 1184607.AUCHE_05_03520 2.5e-34 152.1 Actinobacteria mauF 2.7.11.1 ko:K03466,ko:K06196,ko:K12132 ko00000,ko01000,ko01001,ko02000,ko03036 3.A.12,5.A.1.2 Bacteria 2IMP9@201174,COG0785@1,COG0785@2 NA|NA|NA O Cytochrome C biogenesis protein MAG.T12.14_00116 1122622.ATWJ01000002_gene818 1.6e-24 119.0 Intrasporangiaceae ko:K03972 ko00000 Bacteria 2GR81@201174,4FHT9@85021,COG0607@1,COG0607@2 NA|NA|NA P Rhodanese Homology Domain MAG.T12.14_00117 1172188.KB911821_gene1461 7.4e-188 664.1 Intrasporangiaceae Bacteria 2GM2C@201174,4FIB5@85021,COG2898@1,COG2898@2 NA|NA|NA S Uncharacterised conserved protein (DUF2156) MAG.T12.14_00118 1484479.DI14_14505 9.3e-78 297.0 Bacilli Bacteria 1UFDJ@1239,4HDIH@91061,COG0561@1,COG0561@2 NA|NA|NA G hydrolase MAG.T12.14_00119 1304865.JAGF01000001_gene2261 1.2e-224 785.8 Actinobacteria bglH 3.2.1.86 ko:K01223 ko00010,ko00500,map00010,map00500 R00839,R05133,R05134 RC00049,RC00171,RC00714 ko00000,ko00001,ko01000 GT1 Bacteria 2GJAF@201174,COG2723@1,COG2723@2 NA|NA|NA G Belongs to the glycosyl hydrolase 1 family MAG.T12.14_00120 867903.ThesuDRAFT_01213 5.5e-129 468.0 Clostridiales incertae sedis fumC 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 Bacteria 1UHPH@1239,25F3I@186801,3WCCI@538999,COG0114@1,COG0114@2 NA|NA|NA C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate MAG.T12.14_00121 1032480.MLP_14960 1.7e-67 262.3 Propionibacteriales def 3.5.1.88 ko:K01462 ko00000,ko01000 Bacteria 2GJ87@201174,4DQAV@85009,COG0242@1,COG0242@2 NA|NA|NA J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions MAG.T12.14_00122 526225.Gobs_4775 8.9e-64 250.8 Frankiales rsgA 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 Bacteria 2GMDX@201174,4EU3D@85013,COG1162@1,COG1162@2 NA|NA|NA S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit MAG.T12.14_00124 935866.JAER01000027_gene4225 1.5e-41 176.0 Propionibacteriales Bacteria 2IME3@201174,4DWV7@85009,COG2716@1,COG2716@2 NA|NA|NA E ACT domain MAG.T12.14_00125 1894.JOER01000022_gene3926 3.6e-96 359.0 Actinobacteria 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 Bacteria 2GKPZ@201174,COG0154@1,COG0154@2 NA|NA|NA J Belongs to the amidase family MAG.T12.14_00126 420324.KI912044_gene3963 8.2e-28 131.0 Methylobacteriaceae ko:K06889 ko00000 Bacteria 1JTW5@119045,1NXZW@1224,2TSEE@28211,COG1073@1,COG1073@2 NA|NA|NA S Uncharacterised protein family (UPF0227) MAG.T12.14_00127 103733.JNYO01000021_gene6755 1.8e-31 143.7 Actinobacteria Bacteria 2H3FK@201174,COG2199@1,COG3706@2,COG5001@1,COG5001@2 NA|NA|NA T diguanylate cyclase MAG.T12.14_00128 1125973.JNLC01000006_gene3027 1.3e-81 309.3 Alphaproteobacteria pfpI 3.5.1.124 ko:K05520 ko00000,ko01000,ko01002 Bacteria 1MY0C@1224,2TU62@28211,COG0693@1,COG0693@2 NA|NA|NA S Intracellular protease MAG.T12.14_00129 1278078.G419_24269 9.9e-63 246.5 Nocardiaceae Bacteria 2GNR0@201174,4FXM7@85025,COG2119@1,COG2119@2 NA|NA|NA S Uncharacterized protein family UPF0016 MAG.T12.14_00130 1108045.GORHZ_141_00770 2.6e-13 80.9 Actinobacteria Bacteria 2EMYX@1,2GZ6D@201174,33FM2@2 NA|NA|NA MAG.T12.14_00131 1463901.JOIY01000037_gene7073 4.2e-52 211.8 Actinobacteria Bacteria 2H9P8@201174,COG0697@1,COG0697@2 NA|NA|NA EG spore germination MAG.T12.14_00132 1304876.AZVC01000001_gene1260 2.8e-27 128.3 Micrococcaceae Bacteria 1WA7S@1268,2IQEW@201174,COG1725@1,COG1725@2 NA|NA|NA K helix_turn_helix gluconate operon transcriptional repressor MAG.T12.14_00133 446466.Cfla_1316 2.4e-20 106.3 Actinobacteria Bacteria 2ERYQ@1,2GXQP@201174,33JHV@2 NA|NA|NA MAG.T12.14_00134 1123258.AQXZ01000019_gene3032 8.2e-105 387.5 Nocardiaceae Bacteria 2I5AX@201174,4FX6Y@85025,COG0477@1,COG2814@2 NA|NA|NA EGP Major Facilitator Superfamily MAG.T12.14_00135 1120965.AUBV01000015_gene1112 6.5e-08 65.1 Bacteroidetes Bacteria 4NMM2@976,COG2120@1,COG2120@2 NA|NA|NA S GlcNAc-PI de-N-acetylase MAG.T12.14_00136 710685.MycrhN_1550 4.3e-222 777.7 Mycobacteriaceae pepO 3.4.24.11,3.4.24.71 ko:K01389,ko:K01415,ko:K07386 ko04614,ko04640,ko04974,ko05010,map04614,map04640,map04974,map05010 ko00000,ko00001,ko01000,ko01002,ko04090,ko04147 Bacteria 2331P@1762,2GNJY@201174,COG3590@1,COG3590@2 NA|NA|NA O peptidase MAG.T12.14_00137 1156844.KB891814_gene6810 3.7e-42 178.3 Actinobacteria alkD Bacteria 2GNQD@201174,COG4912@1,COG4912@2 NA|NA|NA L DNA alkylation repair MAG.T12.14_00138 1148.1652140 1.1e-174 619.8 Synechocystis gadB 4.1.1.15 ko:K01580 ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940 M00027 R00261,R00489,R01682,R02466 RC00299 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv3432c Bacteria 1G47D@1117,1H682@1142,COG0076@1,COG0076@2 NA|NA|NA E Pyridoxal-dependent decarboxylase conserved domain MAG.T12.14_00139 1298863.AUEP01000001_gene1023 1.9e-99 369.0 Propionibacteriales Bacteria 2I8NG@201174,30Y0T@2,4DW1P@85009,arCOG10607@1 NA|NA|NA MAG.T12.14_00140 1121920.AUAU01000018_gene1775 4e-17 94.7 Acidobacteria Bacteria 3Y4HW@57723,COG2318@1,COG2318@2 NA|NA|NA S Mycothiol maleylpyruvate isomerase N-terminal domain MAG.T12.14_00141 404589.Anae109_3092 6.4e-17 95.9 Proteobacteria Bacteria 1N29G@1224,COG3568@1,COG3568@2 NA|NA|NA S Endonuclease/Exonuclease/phosphatase family MAG.T12.14_00143 452652.KSE_07440 1.2e-25 124.4 Actinobacteria 2.1.1.107 ko:K02303,ko:K22010 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121,M00839 R03194 RC00003,RC00871 ko00000,ko00001,ko00002,ko01000,ko02022 Bacteria 2GKG3@201174,COG2203@1,COG2203@2,COG2208@1,COG2208@2,COG3707@1,COG3707@2 NA|NA|NA KT phosphatase MAG.T12.14_00145 1123020.AUIE01000023_gene5023 9.2e-10 69.3 Bacteria Bacteria COG0236@1,COG0236@2 NA|NA|NA IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis MAG.T12.14_00146 405948.SACE_2405 2.7e-91 342.8 Pseudonocardiales aceF 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GN5J@201174,4E8QP@85010,COG0508@1,COG0508@2 NA|NA|NA C 2-oxoacid dehydrogenases acyltransferase (catalytic domain) MAG.T12.14_00147 1449044.JMLE01000025_gene3354 2.2e-134 485.3 Micrococcaceae pdhA 1.2.4.1,1.2.4.4 ko:K00162,ko:K11381 ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00036,M00307 R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1WAY5@1268,2GKFE@201174,COG0022@1,COG0022@2 NA|NA|NA C Transketolase, C-terminal domain MAG.T12.14_00148 290399.Arth_0510 3.5e-122 444.9 Micrococcaceae pdhA 1.2.4.1,1.2.4.4 ko:K00161,ko:K00162,ko:K11381,ko:K21416 ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00036,M00307 R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1WAV4@1268,2IBRC@201174,COG1071@1,COG1071@2 NA|NA|NA C Dehydrogenase E1 component MAG.T12.14_00149 467200.ACFA01000086_gene1346 1.2e-221 776.2 Actinobacteria acsA 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 2GNE8@201174,COG0365@1,COG0365@2 NA|NA|NA I synthetase MAG.T12.14_00150 1123065.ATWL01000009_gene974 4.8e-50 204.1 Actinobacteria 3.6.1.55 ko:K03574 ko00000,ko01000,ko03400 Bacteria 2IKKB@201174,COG1051@1,COG1051@2 NA|NA|NA F Nudix hydrolase MAG.T12.14_00152 103733.JNYO01000008_gene5422 1.4e-46 193.7 Pseudonocardiales Bacteria 2GKAY@201174,4E36B@85010,COG5012@1,COG5012@2 NA|NA|NA S cobalamin binding protein MAG.T12.14_00153 479435.Kfla_5843 3.5e-76 291.2 Propionibacteriales nth 4.2.99.18 ko:K07457,ko:K10773 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 2GNE5@201174,4DQDJ@85009,COG0177@1,COG0177@2 NA|NA|NA L HhH-GPD superfamily base excision DNA repair protein MAG.T12.14_00155 1121106.JQKB01000013_gene5441 1.2e-07 63.9 Alphaproteobacteria Bacteria 1QW7K@1224,2U79M@28211,COG2197@1,COG2197@2 NA|NA|NA K helix_turn_helix, Lux Regulon MAG.T12.14_00156 1280946.HY29_18285 1.2e-36 160.6 Alphaproteobacteria Bacteria 1NPD3@1224,2UX3E@28211,COG2850@1,COG2850@2 NA|NA|NA S Cupin superfamily protein MAG.T12.14_00157 1231391.AMZF01000003_gene3115 2.6e-50 205.7 Alcaligenaceae Bacteria 1N3A2@1224,2W95G@28216,3T7RQ@506,COG1028@1,COG1028@2 NA|NA|NA IQ KR domain MAG.T12.14_00158 1352941.M877_37700 1e-30 141.4 Actinobacteria sagD ko:K09136 ko00000,ko03009 Bacteria 2GKBS@201174,COG1944@1,COG1944@2 NA|NA|NA S YcaO cyclodehydratase, ATP-ad Mg2+-binding MAG.T12.14_00160 1278073.MYSTI_04797 4.8e-63 248.8 Deltaproteobacteria hemN GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 Bacteria 1MU76@1224,2WIM5@28221,42NGU@68525,COG0635@1,COG0635@2 NA|NA|NA H Involved in the biosynthesis of porphyrin-containing compound MAG.T12.14_00161 318586.Pden_4195 8.2e-32 144.4 Alphaproteobacteria sagB Bacteria 1PUI1@1224,2U13C@28211,COG0778@1,COG0778@2 NA|NA|NA C Nitroreductase family MAG.T12.14_00164 1380386.JIAW01000001_gene4637 2.7e-105 389.0 Mycobacteriaceae tdt Bacteria 2357X@1762,2GKPA@201174,COG1275@1,COG1275@2 NA|NA|NA P C4-dicarboxylate transporter malic acid transport protein MAG.T12.14_00165 1169161.KB897741_gene1993 6.2e-90 337.8 Actinobacteria pstS GO:0002682,GO:0002683,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009607,GO:0009987,GO:0009991,GO:0015698,GO:0016020,GO:0016036,GO:0030312,GO:0031347,GO:0031348,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0035821,GO:0040007,GO:0042594,GO:0043207,GO:0044003,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044413,GO:0044414,GO:0044419,GO:0044464,GO:0045088,GO:0045824,GO:0048519,GO:0048583,GO:0048585,GO:0050776,GO:0050777,GO:0050789,GO:0050896,GO:0051179,GO:0051234,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051817,GO:0051832,GO:0051833,GO:0052031,GO:0052037,GO:0052167,GO:0052170,GO:0052173,GO:0052200,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0065007,GO:0071496,GO:0071944,GO:0075136,GO:0080134 ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 ko00000,ko00001,ko00002,ko02000 3.A.1.7 Bacteria 2GJXD@201174,COG0226@1,COG0226@2 NA|NA|NA P Part of the ABC transporter complex PstSACB involved in phosphate import MAG.T12.14_00166 1957.JODX01000009_gene2682 7.5e-95 354.0 Actinobacteria pstC GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0009314,GO:0009628,GO:0010921,GO:0015698,GO:0016020,GO:0016021,GO:0019220,GO:0019222,GO:0031224,GO:0031226,GO:0031323,GO:0034220,GO:0035303,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0055085,GO:0065007,GO:0065009,GO:0071944,GO:0098656,GO:0098660,GO:0098661 ko:K02037,ko:K02038 ko02010,map02010 M00222 ko00000,ko00001,ko00002,ko02000 3.A.1.7 iAF987.Gmet_2702,ic_1306.c4652 Bacteria 2GJDA@201174,COG0573@1,COG0573@2 NA|NA|NA P probably responsible for the translocation of the substrate across the membrane MAG.T12.14_00167 1172179.AUKV01000029_gene7734 1.9e-91 342.8 Actinobacteria pstA GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0010921,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0019220,GO:0019222,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0031323,GO:0033554,GO:0034220,GO:0035303,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0051716,GO:0055085,GO:0065007,GO:0065009,GO:0071944,GO:0098656,GO:0098660,GO:0098661 ko:K02037,ko:K02038 ko02010,map02010 M00222 ko00000,ko00001,ko00002,ko02000 3.A.1.7 iJN746.PP_2658,iPC815.YPO4115,iYL1228.KPN_04131,iZ_1308.Z5217 Bacteria 2I2F2@201174,COG0581@1,COG0581@2 NA|NA|NA P phosphate transport system permease MAG.T12.14_00168 1095772.CAHH01000068_gene347 3.9e-110 404.4 Actinobacteria pstB 3.6.3.27 ko:K02036 ko02010,map02010 M00222 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 Bacteria 2GJQ3@201174,COG1117@1,COG1117@2 NA|NA|NA P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system MAG.T12.14_00169 526226.Gbro_2863 2e-82 312.8 Gordoniaceae GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009436,GO:0009987,GO:0015977,GO:0016054,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0032787,GO:0043427,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046185,GO:0046395,GO:0046487,GO:0071704,GO:0072329,GO:1901575 4.1.3.4,4.1.3.46 ko:K01640,ko:K18314 ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146 M00036,M00088 R01360,R08090,R10674 RC00502,RC00503,RC01118,RC01205,RC01946 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKTP@201174,4GBZC@85026,COG0119@1,COG0119@2 NA|NA|NA E HMGL-like MAG.T12.14_00170 1380347.JNII01000006_gene1701 3.3e-129 468.4 Frankiales glgC GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008878,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0070566,GO:0071704,GO:1901576 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2768 Bacteria 2I2EF@201174,4ERNH@85013,COG0448@1,COG0448@2 NA|NA|NA H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans MAG.T12.14_00171 345341.KUTG_04253 1.7e-138 499.2 Pseudonocardiales glgA GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901576 2.4.1.342 ko:K16148 ko00500,ko01100,map00500,map01100 R02421,R11530 RC00005,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 GT4 Bacteria 2I2EE@201174,4E0K3@85010,COG0297@1,COG0297@2 NA|NA|NA G Glycosyl transferase 4-like domain MAG.T12.14_00172 397278.JOJN01000007_gene3359 3.7e-117 428.7 Propionibacteriales Bacteria 2GWA2@201174,2Z9VM@2,4DQ3R@85009,COG1524@1 NA|NA|NA S mannose-ethanolamine phosphotransferase activity MAG.T12.14_00174 1050202.KB913024_gene55 2.7e-116 425.6 Actinopolysporales Bacteria 2GKGM@201174,407NC@622450,COG2733@1,COG2733@2 NA|NA|NA S Protein of unknown function (DUF445) MAG.T12.14_00175 1032480.MLP_00530 3.9e-107 395.2 Propionibacteriales pit ko:K03306 ko00000 2.A.20 Bacteria 2GJHK@201174,4DND5@85009,COG0306@1,COG0306@2 NA|NA|NA P Phosphate transporter family MAG.T12.14_00176 101510.RHA1_ro03323 2.2e-90 338.6 Nocardiaceae Bacteria 2GMSB@201174,4FXCP@85025,COG2013@1,COG2013@2 NA|NA|NA T Mitochondrial biogenesis AIM24 MAG.T12.14_00177 1120950.KB892759_gene6277 3.5e-76 292.4 Propionibacteriales Bacteria 2I2J0@201174,4DQBJ@85009,COG2385@1,COG2385@2 NA|NA|NA D PFAM Stage II sporulation D domain protein MAG.T12.14_00178 1229780.BN381_100067 3.7e-60 238.4 unclassified Actinobacteria (class) hrtA 3.6.3.25 ko:K02003,ko:K06020,ko:K09810,ko:K09814 ko02010,map02010 M00255,M00257,M00258 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.125 Bacteria 2GNB3@201174,3UXF5@52018,COG1136@1,COG1136@2 NA|NA|NA V ATPases associated with a variety of cellular activities MAG.T12.14_00179 1313172.YM304_38290 1.5e-38 167.2 Actinobacteria ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GMC4@201174,COG0577@1,COG0577@2 NA|NA|NA V ABC-type antimicrobial peptide transport system, permease component MAG.T12.14_00180 1229780.BN381_100069 3.5e-32 146.0 Bacteria ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria COG0577@1,COG0577@2 NA|NA|NA V efflux transmembrane transporter activity MAG.T12.14_00181 1120949.KB903328_gene8960 7.2e-09 68.6 Micromonosporales Bacteria 2DMZ3@1,2IQMH@201174,32UHB@2,4DFK7@85008 NA|NA|NA S Predicted membrane protein (DUF2157) MAG.T12.14_00182 479432.Sros_8729 6.3e-148 530.8 Streptosporangiales nplT 3.2.1.1 ko:K01176 ko00500,ko01100,ko04973,map00500,map01100,map04973 R02108,R02112,R11262 ko00000,ko00001,ko01000 GH13 Bacteria 2GJUT@201174,4EIF5@85012,COG0366@1,COG0366@2 NA|NA|NA G Alpha amylase, catalytic domain MAG.T12.14_00183 768671.ThimaDRAFT_1447 1.3e-79 303.9 Chromatiales ggt 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 Bacteria 1MUV6@1224,1SMH6@1236,1X0JB@135613,COG0405@1,COG0405@2 NA|NA|NA E Gamma-glutamyltranspeptidase MAG.T12.14_00184 1205910.B005_1121 2.2e-94 352.8 Streptosporangiales amiA ko:K01436,ko:K06048 ko00000,ko01000,ko01002 Bacteria 2GK05@201174,4EHXK@85012,COG1473@1,COG1473@2 NA|NA|NA S Peptidase dimerisation domain MAG.T12.14_00185 926569.ANT_20770 3.1e-16 90.9 Chloroflexi mrx1 1.20.4.3 ko:K18917 ko00000,ko01000 Bacteria 2G75B@200795,COG0695@1,COG0695@2 NA|NA|NA O Glutathione S-transferase, N-terminal domain MAG.T12.14_00186 1121017.AUFG01000020_gene2298 2.4e-37 161.8 Intrasporangiaceae dcdA 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 Bacteria 2IJ94@201174,4FHCM@85021,COG2131@1,COG2131@2 NA|NA|NA F MafB19-like deaminase MAG.T12.14_00187 1306174.JODP01000001_gene5170 1.7e-50 206.5 Actinobacteria yeaD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716 4.2.1.9,5.1.3.15 ko:K01687,ko:K01792 ko00010,ko00290,ko00770,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00010,map00290,map00770,map01100,map01110,map01120,map01130,map01210,map01230 M00019,M00570 R01209,R02739,R04441,R05070 RC00468,RC00563,RC01714 ko00000,ko00001,ko00002,ko01000 Bacteria 2IIUH@201174,COG0676@1,COG0676@2 NA|NA|NA G Belongs to the glucose-6-phosphate 1-epimerase family MAG.T12.14_00188 1305732.JAGG01000001_gene909 7e-109 401.7 Actinobacteria ykoD 3.6.3.24 ko:K02031,ko:K02032,ko:K10824,ko:K15587,ko:K16785,ko:K16786,ko:K16787 ko02010,ko02024,map02010,map02024 M00239,M00440,M00582 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35,3.A.1.5 Bacteria 2I2G4@201174,COG0619@1,COG0619@2,COG1123@1,COG4172@2 NA|NA|NA P Cobalt transport protein MAG.T12.14_00189 1122182.KB903816_gene1683 1.1e-53 216.5 Micromonosporales ykoE ko:K16925 M00582 ko00000,ko00002,ko02000 3.A.1.30 Bacteria 2IDAN@201174,4D9S6@85008,COG4721@1,COG4721@2 NA|NA|NA S ABC-type cobalt transport system, permease component MAG.T12.14_00190 2002.JOEQ01000009_gene6516 1.6e-62 246.1 Streptosporangiales yplQ ko:K11068 ko00000,ko02042 Bacteria 2GJGQ@201174,4EIGX@85012,COG1272@1,COG1272@2 NA|NA|NA S Haemolysin-III related MAG.T12.14_00191 411459.RUMOBE_00192 7.4e-11 73.2 Blautia Bacteria 1VEJY@1239,24QJW@186801,3Y0K2@572511,COG3326@1,COG3326@2 NA|NA|NA S Psort location CytoplasmicMembrane, score MAG.T12.14_00192 195250.CM001776_gene511 1.5e-76 293.1 Synechococcus 1.1.1.219 ko:K00091 ko00000,ko01000 Bacteria 1G2DP@1117,1H3Z1@1129,COG0451@1,COG0451@2 NA|NA|NA M NmrA-like family MAG.T12.14_00194 1172188.KB911821_gene1996 9.1e-155 553.9 Intrasporangiaceae Bacteria 2HXIC@201174,4FH0P@85021,COG0471@1,COG0471@2 NA|NA|NA P Sodium:sulfate symporter transmembrane region MAG.T12.14_00195 326424.FRAAL6407 8.7e-153 547.4 Frankiales atzF 3.5.1.54 ko:K01457 ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120 R00005 RC02756 ko00000,ko00001,ko01000 Bacteria 2GSBS@201174,4ERN1@85013,COG0154@1,COG0154@2,COG2105@1,COG2105@2 NA|NA|NA J Amidase MAG.T12.14_00196 365528.KB891208_gene2813 3.8e-107 394.4 Frankiales rutB Bacteria 2I9AW@201174,4ERJC@85013,COG1335@1,COG1335@2 NA|NA|NA Q PFAM Isochorismatase MAG.T12.14_00197 1209072.ALBT01000033_gene1686 2.2e-23 115.9 Gammaproteobacteria rutB Bacteria 1MV0W@1224,1RU8R@1236,COG1335@1,COG1335@2 NA|NA|NA Q Amidases related to nicotinamidase MAG.T12.14_00198 1123258.AQXZ01000014_gene4982 7e-120 437.2 Nocardiaceae ko:K02058,ko:K07335 M00221 ko00000,ko00002,ko02000 3.A.1.2 Bacteria 2HHEG@201174,4FY9I@85025,COG1744@1,COG1744@2 NA|NA|NA S ABC transporter substrate-binding protein PnrA-like MAG.T12.14_00199 298654.FraEuI1c_0532 6.9e-108 397.5 Actinobacteria rbsC-2 ko:K02057 M00221 ko00000,ko00002,ko02000 3.A.1.2 Bacteria 2GKMB@201174,COG1079@1,COG1079@2 NA|NA|NA S Belongs to the binding-protein-dependent transport system permease family MAG.T12.14_00200 298654.FraEuI1c_0533 6.7e-97 360.9 Frankiales ko:K02057 M00221 ko00000,ko00002,ko02000 3.A.1.2 Bacteria 2GKAZ@201174,4EU1I@85013,COG4603@1,COG4603@2 NA|NA|NA S Belongs to the binding-protein-dependent transport system permease family MAG.T12.14_00201 1123258.AQXZ01000014_gene4985 5.2e-167 594.3 Nocardiaceae mglA 3.6.3.17 ko:K02056 M00221 ko00000,ko00002,ko01000,ko02000 3.A.1.2 Bacteria 2H7KJ@201174,4G9EK@85025,COG3845@1,COG3845@2 NA|NA|NA S ATPases associated with a variety of cellular activities MAG.T12.14_00202 326424.FRAAL6405 2.7e-71 275.4 Frankiales ntaR Bacteria 2IDZ6@201174,4ET86@85013,COG1802@1,COG1802@2 NA|NA|NA K FCD MAG.T12.14_00203 479433.Caci_6448 2e-59 235.7 Actinobacteria Bacteria 2F0VE@1,2INWW@201174,33TX8@2 NA|NA|NA MAG.T12.14_00204 446471.Xcel_0031 1.9e-111 409.5 Actinobacteria Bacteria 2GWBV@201174,COG1672@1,COG1672@2 NA|NA|NA S AAA ATPase domain MAG.T12.14_00205 1122599.AUGR01000005_gene1973 1.9e-126 459.5 Oceanospirillales Bacteria 1MWUX@1224,1RQ8G@1236,1XK8Z@135619,COG0076@1,COG0076@2 NA|NA|NA E Glutamate decarboxylase and related PLP-dependent MAG.T12.14_00206 479435.Kfla_0655 1.4e-35 155.6 Propionibacteriales Bacteria 2IKXW@201174,4DR3R@85009,COG3824@1,COG3824@2 NA|NA|NA S Zincin-like metallopeptidase MAG.T12.14_00207 1121272.KB903289_gene4351 1.8e-95 355.9 Actinobacteria Bacteria 2IB3X@201174,COG5640@1,COG5640@2 NA|NA|NA O Trypsin-like serine protease MAG.T12.14_00208 1211815.CBYP010000045_gene795 1.3e-78 300.4 Frankiales ybdK GO:0003674,GO:0003824,GO:0016874,GO:0016879 ko:K06048 ko00000,ko01000 Bacteria 2GKAA@201174,4ES1F@85013,COG2170@1,COG2170@2 NA|NA|NA S ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity MAG.T12.14_00209 1304865.JAGF01000001_gene1186 6.4e-155 555.1 Actinobacteria Bacteria 2IAWA@201174,COG2199@1,COG2202@1,COG2202@2,COG3706@2 NA|NA|NA T diguanylate cyclase MAG.T12.14_00210 1380356.JNIK01000013_gene4301 2.1e-50 204.9 Frankiales Bacteria 2GR1G@201174,4EWZ9@85013,COG3631@1,COG3631@2 NA|NA|NA S SnoaL-like polyketide cyclase MAG.T12.14_00211 1380370.JIBA01000006_gene3355 3.3e-83 314.7 Intrasporangiaceae ko:K07118 ko00000 Bacteria 2GK2P@201174,4FH0H@85021,COG2910@1,COG2910@2 NA|NA|NA S NAD(P)H-binding MAG.T12.14_00212 1380370.JIBA01000011_gene3042 3.5e-135 488.0 Intrasporangiaceae Bacteria 299PK@1,2ICYR@201174,2ZWRX@2,4FEZK@85021 NA|NA|NA S Rifampin ADP-ribosyl transferase MAG.T12.14_00213 1380393.JHVP01000015_gene4172 2.1e-58 231.9 Frankiales 3.2.2.1 ko:K01239 ko00230,ko00760,ko01100,map00230,map00760,map01100 R01245,R01273,R01677,R01770,R02143 RC00033,RC00063,RC00122,RC00318,RC00485 ko00000,ko00001,ko01000 Bacteria 2IFKS@201174,4EVNQ@85013,COG0346@1,COG0346@2 NA|NA|NA E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily MAG.T12.14_00214 1385520.N802_03220 2.4e-261 908.7 Intrasporangiaceae vpr GO:0005575,GO:0005576 ko:K14647 ko02024,map02024 ko00000,ko00001,ko01000,ko01002,ko03110 Bacteria 2GK3D@201174,4FE2Y@85021,COG1404@1,COG1404@2 NA|NA|NA O PA domain MAG.T12.14_00215 357808.RoseRS_1515 4.2e-12 78.2 Chloroflexia Bacteria 2DRD4@1,2G9Z1@200795,33B9X@2,377FH@32061 NA|NA|NA MAG.T12.14_00216 477641.MODMU_2166 6.6e-49 200.7 Frankiales Bacteria 2IIBU@201174,308PC@2,4EV3D@85013,arCOG14808@1 NA|NA|NA S Domain of unknown function (DUF4956) MAG.T12.14_00217 1869.MB27_41620 4.7e-48 198.4 Micromonosporales ygiF GO:0003674,GO:0003824,GO:0005488,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0043167,GO:0043169,GO:0046872,GO:0050355 3.6.1.25 ko:K18446 ko00000,ko01000 Bacteria 2II2C@201174,4DCSN@85008,COG3025@1,COG3025@2 NA|NA|NA S VTC domain MAG.T12.14_00218 1095767.CAHD01000028_gene1705 4.4e-64 252.7 Cellulomonadaceae Bacteria 2GKIT@201174,2Z8AD@2,4F0EE@85016,arCOG08054@1 NA|NA|NA S Carbohydrate-binding domain-containing protein Cthe_2159 MAG.T12.14_00220 110319.CF8_3589 5.2e-66 258.8 Propionibacteriales Bacteria 2ICM5@201174,4DQ8D@85009,COG4421@1,COG4421@2 NA|NA|NA G Protein of unknown function (DUF563) MAG.T12.14_00221 479431.Namu_0418 1.9e-88 332.8 Frankiales Bacteria 2GIS3@201174,4EU7J@85013,COG0604@1,COG0604@2 NA|NA|NA C alcohol dehydrogenase MAG.T12.14_00222 1385519.N801_00245 1.2e-63 250.0 Intrasporangiaceae Bacteria 2DBV7@1,2IGRZ@201174,2ZB9P@2,4FHPC@85021 NA|NA|NA S Domain of unknown function (DUF4386) MAG.T12.14_00223 1304865.JAGF01000001_gene432 8e-18 96.3 Actinobacteria Bacteria 2DBV7@1,2IGRZ@201174,2ZB9P@2 NA|NA|NA S Domain of unknown function (DUF4386) MAG.T12.14_00224 1122609.AUGT01000013_gene4105 1.1e-242 846.7 Propionibacteriales ko:K03556 ko00000,ko03000 Bacteria 2I50W@201174,4DPMG@85009,COG2909@1,COG2909@2 NA|NA|NA K helix_turn_helix, Lux Regulon MAG.T12.14_00225 479431.Namu_0429 1.3e-57 229.6 Frankiales 1.8.1.9 ko:K00384 ko00450,map00450 R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 Bacteria 2GIXN@201174,4ESGA@85013,COG0492@1,COG0492@2 NA|NA|NA O Pyridine nucleotide-disulphide oxidoreductase MAG.T12.14_00226 1032480.MLP_34390 2.1e-44 185.3 Propionibacteriales adk 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2I45A@201174,4DSTH@85009,COG0563@1,COG0563@2 NA|NA|NA F AAA domain MAG.T12.14_00228 1171373.PACID_21720 3.8e-27 127.5 Actinobacteria Bacteria 2GXCS@201174,COG2361@1,COG2361@2 NA|NA|NA S Protein of unknown function DUF86 MAG.T12.14_00229 1035308.AQYY01000001_gene2076 1.3e-44 186.0 Bacteria ko:K07075 ko00000 Bacteria COG1669@1,COG1669@2 NA|NA|NA S nucleotidyltransferase activity MAG.T12.14_00231 1321778.HMPREF1982_01855 1e-59 237.3 Clostridia 2.7.1.15,2.7.1.187,2.7.1.45 ko:K00852,ko:K00874,ko:K19978 ko00030,ko00525,ko01100,ko01120,ko01130,ko01200,map00030,map00525,map01100,map01120,map01130,map01200 M00061,M00308,M00631 R01051,R01541,R02750,R11184 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 1TRRQ@1239,24D41@186801,COG0524@1,COG0524@2 NA|NA|NA G pfkB family carbohydrate kinase MAG.T12.14_00232 446470.Snas_3927 5.7e-19 101.3 Glycomycetales Bacteria 2GQRD@201174,4EZTI@85014,COG1309@1,COG1309@2 NA|NA|NA K Tetracyclin repressor, C-terminal all-alpha domain MAG.T12.14_00234 1386089.N865_05300 2.3e-24 119.4 Actinobacteria Bacteria 2BFB8@1,2ISHF@201174,32949@2 NA|NA|NA MAG.T12.14_00236 471853.Bcav_3697 1e-70 273.9 Actinobacteria Bacteria 2GIS3@201174,COG0604@1,COG0604@2 NA|NA|NA C alcohol dehydrogenase MAG.T12.14_00237 1206737.BAGF01000151_gene6270 2.4e-72 279.3 Nocardiaceae Bacteria 2GIS3@201174,4FYN0@85025,COG0604@1,COG0604@2 NA|NA|NA C Zinc-binding dehydrogenase MAG.T12.14_00239 710696.Intca_0451 1.1e-301 1042.3 Intrasporangiaceae 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 GH31 Bacteria 2GP4V@201174,4FG4A@85021,COG1501@1,COG1501@2 NA|NA|NA G Glycosyl hydrolases family 31 MAG.T12.14_00240 446471.Xcel_0725 5.4e-21 107.8 Promicromonosporaceae Bacteria 2IRV0@201174,4F4YK@85017,COG0542@1,COG0542@2 NA|NA|NA O Clp amino terminal domain, pathogenicity island component MAG.T12.14_00241 749927.AMED_5979 3.3e-13 80.5 Pseudonocardiales Bacteria 2E3V5@1,2GTV6@201174,345UQ@2,4ED36@85010 NA|NA|NA S Homeodomain-like domain MAG.T12.14_00243 1386089.N865_19910 3.2e-119 435.3 Intrasporangiaceae ko:K07222 ko00000 Bacteria 2GM3S@201174,4FFFI@85021,COG2072@1,COG2072@2 NA|NA|NA P L-lysine 6-monooxygenase (NADPH-requiring) MAG.T12.14_00245 710111.FraQA3DRAFT_1948 7.6e-107 394.0 Frankiales Bacteria 28H9S@1,2HZP4@201174,2Z7ME@2,4EU66@85013 NA|NA|NA S GDSL-like Lipase/Acylhydrolase MAG.T12.14_00247 1120950.KB892739_gene4000 5.2e-130 471.1 Propionibacteriales hemN GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 iNJ661.Rv2388c Bacteria 2GJXX@201174,4DN32@85009,COG0635@1,COG0635@2 NA|NA|NA H Involved in the biosynthesis of porphyrin-containing compound MAG.T12.14_00248 1123508.JH636440_gene2073 5.8e-09 67.8 Planctomycetes Bacteria 2J1MD@203682,COG2314@1,COG2314@2 NA|NA|NA S TM2 domain MAG.T12.14_00249 58344.JOEL01000008_gene1598 6.3e-90 337.4 Actinobacteria trpH GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004534,GO:0004536,GO:0004540,GO:0005488,GO:0006139,GO:0006259,GO:0006521,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008409,GO:0009987,GO:0010565,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016796,GO:0016895,GO:0016896,GO:0019222,GO:0030145,GO:0031323,GO:0033238,GO:0034641,GO:0035312,GO:0042578,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0090357,GO:0090501,GO:0090503,GO:0097657,GO:0140097,GO:0140098,GO:1901360 3.1.3.97 ko:K07053 R00188,R11188 RC00078 ko00000,ko01000 Bacteria 2GIZ5@201174,COG0613@1,COG0613@2 NA|NA|NA S Protein of unknown function (DUF3097) MAG.T12.14_00250 1134445.AJJM01000004_gene3443 1.7e-118 432.6 Actinobacteria hrcA GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 ko:K03705 ko00000,ko03000 Bacteria 2GKF5@201174,COG1420@1,COG1420@2 NA|NA|NA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons MAG.T12.14_00251 47763.JNZA01000003_gene3958 9.9e-147 526.6 Actinobacteria dnaJ GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944 ko:K03686 ko00000,ko03029,ko03110 Bacteria 2GK69@201174,COG0484@1,COG0484@2 NA|NA|NA O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins MAG.T12.14_00252 67352.JODS01000019_gene2705 6.2e-65 254.2 Actinobacteria rsmE 1.13.12.16,2.1.1.193 ko:K00459,ko:K09761 ko00910,map00910 R00025 RC02541,RC02759 ko00000,ko00001,ko01000,ko03009 Bacteria 2GTKX@201174,COG1385@1,COG1385@2 NA|NA|NA J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit MAG.T12.14_00253 40571.JOEA01000016_gene46 5.9e-31 140.2 Pseudonocardiales hinT GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019478,GO:0019752,GO:0043436,GO:0043530,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046144,GO:0046395,GO:0046416,GO:0046436,GO:0055130,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.1.1.226,2.1.1.227 ko:K02503,ko:K06442 ko00000,ko01000,ko03009,ko04147 Bacteria 2IHPT@201174,4E5MT@85010,COG0537@1,COG0537@2 NA|NA|NA FG HIT family hydrolase, diadenosine tetraphosphate hydrolase MAG.T12.14_00254 1122609.AUGT01000023_gene513 1.8e-131 475.7 Propionibacteriales phoH GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K06217 ko00000 Bacteria 2GK0W@201174,4DPI2@85009,COG1702@1,COG1702@2 NA|NA|NA T PhoH-like protein MAG.T12.14_00255 570268.ANBB01000046_gene1392 8.7e-46 189.9 Streptosporangiales ybeY GO:0000469,GO:0000478,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006355,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016072,GO:0016151,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0019219,GO:0019222,GO:0019538,GO:0022613,GO:0030490,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043244,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141 2.6.99.2,3.5.4.5 ko:K01489,ko:K03474,ko:K03595,ko:K07042 ko00240,ko00750,ko00983,ko01100,map00240,map00750,map00983,map01100 M00124 R01878,R02485,R05838,R08221 RC00074,RC00514,RC01476 ko00000,ko00001,ko00002,ko01000,ko03009,ko03029 Bacteria 2GMUF@201174,4EIYX@85012,COG0319@1,COG0319@2 NA|NA|NA S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA MAG.T12.14_00256 1120936.KB907220_gene1928 1.6e-119 436.4 Streptosporangiales corC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 2GIWR@201174,4EFYG@85012,COG1253@1,COG1253@2 NA|NA|NA S Transporter associated domain MAG.T12.14_00257 1463856.JOHY01000067_gene7125 3.7e-115 421.4 Actinobacteria era GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043021,GO:0043024,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070181,GO:0070925,GO:0071826,GO:0071840,GO:0097159,GO:1901363 ko:K03595 ko00000,ko03009,ko03029 Bacteria 2GJJE@201174,COG1159@1,COG1159@2 NA|NA|NA M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism MAG.T12.14_00258 526225.Gobs_3844 4.5e-141 508.1 Frankiales deaD 3.6.4.13 ko:K05592,ko:K11927 ko03018,map03018 ko00000,ko00001,ko01000,ko03009,ko03019 Bacteria 2GIUR@201174,4ES4U@85013,COG0513@1,COG0513@2 NA|NA|NA L DEAD DEAH box helicase domain protein MAG.T12.14_00259 1172188.KB911821_gene1489 5.5e-82 311.6 Intrasporangiaceae Bacteria 2GN4Y@201174,4FF71@85021,COG0628@1,COG0628@2 NA|NA|NA S AI-2E family transporter MAG.T12.14_00260 471853.Bcav_1766 2.9e-83 315.1 Actinobacteria recO GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 ko:K03584 ko03440,map03440 ko00000,ko00001,ko03400 Bacteria 2GK81@201174,COG1381@1,COG1381@2 NA|NA|NA L Involved in DNA repair and RecF pathway recombination MAG.T12.14_00261 397278.JOJN01000001_gene3042 7.3e-28 130.6 Propionibacteriales Bacteria 2GWCE@201174,4DV6A@85009,COG2453@1,COG2453@2 NA|NA|NA T Dual specificity phosphatase, catalytic domain MAG.T12.14_00262 58123.JOFJ01000001_gene3316 7.3e-118 430.3 Streptosporangiales uppS GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008834,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0050347,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617 2.5.1.31,2.5.1.86,2.5.1.88 ko:K00806,ko:K14215,ko:K21273 ko00900,ko01110,map00900,map01110 R06447,R09244,R09731 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 Bacteria 2GIXF@201174,4EG00@85012,COG0020@1,COG0020@2 NA|NA|NA I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids MAG.T12.14_00264 1504319.GM45_0330 1.1e-224 785.8 unclassified Actinobacteria (class) glyQS GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009345,GO:0009987,GO:0010467,GO:0016070,GO:0016594,GO:0016597,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0042165,GO:0042802,GO:0042803,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046983,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.14 ko:K01880 ko00970,map00970 M00359,M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 iSB619.SA_RS07880 Bacteria 2GIT3@201174,3UW9K@52018,COG0423@1,COG0423@2 NA|NA|NA J Catalyzes the attachment of glycine to tRNA(Gly) MAG.T12.14_00266 1048339.KB913029_gene4777 9.7e-128 463.4 Frankiales dus Bacteria 2GJ8I@201174,4ERGB@85013,COG0042@1,COG0042@2 NA|NA|NA J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines MAG.T12.14_00267 1504822.CCNO01000011_gene176 5.1e-97 361.7 unclassified Bacteria malS 3.2.1.1 ko:K01176 ko00500,ko01100,ko04973,map00500,map01100,map04973 R02108,R02112,R11262 ko00000,ko00001,ko01000 GH13 Bacteria 2NPAG@2323,COG0366@1,COG0366@2 NA|NA|NA G PFAM Alpha amylase, catalytic MAG.T12.14_00268 1160137.KB907307_gene3773 2.2e-160 572.4 Nocardiaceae aglA 3.2.1.10,3.2.1.20,3.2.1.93 ko:K01182,ko:K01187,ko:K01226 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00028,R00801,R00802,R00837,R01718,R01791,R06087,R06088,R06113,R06199 RC00028,RC00049,RC00059,RC00077,RC00451 ko00000,ko00001,ko01000 GH13,GH31 Bacteria 2GKS4@201174,4FUMW@85025,COG0366@1,COG0366@2 NA|NA|NA G Alpha-amylase domain MAG.T12.14_00269 44060.JODL01000005_gene651 0.0 1281.2 Actinobacteria ppdK 2.7.3.13,2.7.9.1 ko:K01006,ko:K22424 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 Bacteria 2GK73@201174,COG0574@1,COG0574@2,COG1080@1,COG1080@2 NA|NA|NA G Belongs to the PEP-utilizing enzyme family MAG.T12.14_00270 1123322.KB904724_gene2000 3.7e-131 474.9 Actinobacteria dgt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.1.5.1 ko:K01129 ko00230,map00230 R01856 RC00017 ko00000,ko00001,ko01000 Bacteria 2GJ8F@201174,COG0232@1,COG0232@2 NA|NA|NA F Deoxyguanosinetriphosphate triphosphohydrolase-like protein MAG.T12.14_00271 1123023.JIAI01000007_gene1976 5e-30 137.9 Pseudonocardiales Bacteria 2I2NF@201174,4E2P9@85010,COG1434@1,COG1434@2 NA|NA|NA S DUF218 domain MAG.T12.14_00272 351607.Acel_0806 1.7e-183 649.4 Frankiales dnaG GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 ko:K02316 ko03030,map03030 ko00000,ko00001,ko01000,ko03032 Bacteria 2GJFX@201174,4ERCW@85013,COG0358@1,COG0358@2 NA|NA|NA L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication MAG.T12.14_00273 469371.Tbis_1189 3.5e-19 101.7 Actinobacteria hup GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009889,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2001141 ko:K03530 ko00000,ko03032,ko03036,ko03400 Bacteria 2IR95@201174,COG0776@1,COG0776@2 NA|NA|NA L regulation of translation MAG.T12.14_00274 1121933.AUHH01000022_gene2486 6.4e-24 118.6 Propionibacteriales 4.4.1.32 ko:K02289 ko00196,ko01100,map00196,map01100 ko00000,ko00001,ko00194,ko01000 Bacteria 2GITU@201174,4DVW4@85009,COG1413@1,COG1413@2 NA|NA|NA C HEAT repeats MAG.T12.14_00275 1035308.AQYY01000002_gene584 1.8e-39 170.2 Peptococcaceae nolA ko:K19591 M00769 ko00000,ko00002,ko01504,ko03000 Bacteria 1V8GZ@1239,25M6J@186801,26621@186807,COG0789@1,COG0789@2 NA|NA|NA K helix_turn_helix, mercury resistance MAG.T12.14_00278 1907.SGLAU_10165 1.4e-53 216.9 Actinobacteria Bacteria 2GKT0@201174,COG0583@1,COG0583@2 NA|NA|NA K transcriptional regulator MAG.T12.14_00281 1003195.SCAT_3393 4.2e-61 241.5 Actinobacteria trmB GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0040007,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.297,2.1.1.33,2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02493,ko:K02527,ko:K03439 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763,R10806 RC00003,RC00009,RC00077,RC00247,RC03279 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005,ko03012,ko03016 GT30 Bacteria 2GJ8R@201174,COG0220@1,COG0220@2 NA|NA|NA J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA MAG.T12.14_00282 1385520.N802_05395 2.1e-64 252.3 Intrasporangiaceae 1.5.1.40 ko:K06988 ko00000,ko01000 Bacteria 2GMN3@201174,4FJWG@85021,COG2085@1,COG2085@2 NA|NA|NA S NADP oxidoreductase MAG.T12.14_00283 298654.FraEuI1c_5203 5.3e-125 454.1 Frankiales yhhW_2 ko:K06911 ko00000 Bacteria 2GIY9@201174,4ES53@85013,COG1741@1,COG1741@2 NA|NA|NA S Belongs to the pirin family MAG.T12.14_00284 1123322.KB904701_gene313 3.7e-107 394.8 Actinobacteria mutY ko:K03575 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 2GJD9@201174,COG1194@1,COG1194@2 NA|NA|NA L adenine glycosylase MAG.T12.14_00287 512565.AMIS_45090 5.6e-93 347.8 Bacteria Bacteria COG1808@1,COG1808@2 NA|NA|NA S Domain of unknown function (DUF389) MAG.T12.14_00288 1236902.ANAS01000009_gene2473 4.3e-73 282.3 Streptosporangiales 3.5.1.104 ko:K22278 ko00000,ko01000 Bacteria 2HEQK@201174,4EI91@85012,COG0726@1,COG0726@2 NA|NA|NA G Polysaccharide deacetylase MAG.T12.14_00291 195250.CM001776_gene2666 1.3e-21 110.9 Synechococcus tir 3.4.11.19 ko:K01266,ko:K07052 ko00000,ko01000,ko01002 Bacteria 1G6D9@1117,1H119@1129,COG1266@1,COG1266@2 NA|NA|NA S CAAX protease self-immunity MAG.T12.14_00292 1385518.N798_04100 1.4e-14 86.7 Intrasporangiaceae Bacteria 2GTTI@201174,4FGNQ@85021,COG3976@1,COG3976@2 NA|NA|NA S FMN_bind MAG.T12.14_00293 1380390.JIAT01000011_gene2397 4.1e-110 405.2 Rubrobacteria Bacteria 2GKWX@201174,4CRXT@84995,COG4097@1,COG4097@2 NA|NA|NA P FAD-binding domain MAG.T12.14_00294 1214242.B446_25490 3.6e-74 285.8 Actinobacteria treS 2.4.1.18,2.7.1.175,3.2.1.1,5.4.99.16 ko:K00700,ko:K05343,ko:K16146 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01557,R02108,R02110,R02112,R09945,R11262 RC00002,RC00078,RC01816 ko00000,ko00001,ko00002,ko01000,ko04147 CBM48,GH13 Bacteria 2GKAP@201174,COG3281@1,COG3281@2 NA|NA|NA G protein, probably involved in trehalose biosynthesis MAG.T12.14_00295 1463864.JOGO01000009_gene433 1.6e-51 209.1 Actinobacteria Bacteria 299E4@1,2GM90@201174,2ZWGX@2 NA|NA|NA S Protein of unknown function (DUF3145) MAG.T12.14_00296 1283283.ATXA01000038_gene2291 1.3e-63 250.4 Actinobacteria Bacteria 2IAG8@201174,COG3386@1,COG3386@2 NA|NA|NA G PFAM SMP-30 Gluconolaconase MAG.T12.14_00298 1150864.MILUP08_40902 2.1e-26 126.7 Micromonosporales ko:K18566 ko00332,ko01130,map00332,map01130 R10745,R10746 RC00004,RC00096 ko00000,ko00001,ko01000 Bacteria 2I9GA@201174,4DD5V@85008,COG0454@1,COG0456@2 NA|NA|NA K Acetyltransferase (GNAT) family MAG.T12.14_00299 477641.MODMU_1853 0.0 1327.0 Frankiales aceE 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GJRE@201174,4ESAA@85013,COG2609@1,COG2609@2 NA|NA|NA C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) MAG.T12.14_00300 675635.Psed_2142 1.6e-30 139.0 Pseudonocardiales Bacteria 2B57P@1,2IFRB@201174,31Y1M@2,4E3ZW@85010 NA|NA|NA S Protein of unknown function (DUF3052) MAG.T12.14_00301 1304865.JAGF01000001_gene1186 3.6e-162 578.9 Actinobacteria Bacteria 2IAWA@201174,COG2199@1,COG2202@1,COG2202@2,COG3706@2 NA|NA|NA T diguanylate cyclase MAG.T12.14_00302 1211815.CBYP010000014_gene3463 1.3e-35 157.1 Actinobacteria Bacteria 2CK5M@1,2IQNJ@201174,33W5S@2 NA|NA|NA MAG.T12.14_00304 1380393.JHVP01000005_gene3634 4.5e-104 386.0 Frankiales ko:K07027 ko00000,ko02000 4.D.2 Bacteria 2GMAV@201174,4EU4Q@85013,COG0392@1,COG0392@2 NA|NA|NA S Lysylphosphatidylglycerol synthase TM region MAG.T12.14_00305 2074.JNYD01000014_gene7130 2.3e-114 419.1 Pseudonocardiales yqfO GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.5.4.16 ko:K22391 ko00790,ko01100,map00790,map01100 M00126 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKHZ@201174,4DXZJ@85010,COG0327@1,COG0327@2 NA|NA|NA S PFAM NIF3 (NGG1p interacting factor 3) MAG.T12.14_00306 1120936.KB907211_gene211 1.7e-54 219.5 Streptosporangiales ko:K07164 ko00000 Bacteria 2GP84@201174,4EH3Z@85012,COG1579@1,COG1579@2 NA|NA|NA S C4-type zinc ribbon domain MAG.T12.14_00307 66377.JOBH01000001_gene1096 8.9e-96 357.5 Actinobacteria rnhA GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006401,GO:0006725,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016891,GO:0016893,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0032296,GO:0033013,GO:0033014,GO:0034641,GO:0034655,GO:0042364,GO:0042578,GO:0043170,GO:0043755,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046700,GO:0051186,GO:0051188,GO:0071667,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576 3.1.26.4,3.1.3.3,3.1.3.73,3.1.3.85,5.4.2.12 ko:K02226,ko:K03469,ko:K06864,ko:K15634,ko:K22305,ko:K22306,ko:K22316 ko00010,ko00260,ko00680,ko00860,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03030,map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01130,map01200,map01230,map03030 M00001,M00002,M00003,M00122 R00582,R01518,R04594,R11173 RC00017,RC00536 ko00000,ko00001,ko00002,ko01000,ko03032 Bacteria 2GJ9R@201174,COG0328@1,COG0328@2,COG0406@1,COG0406@2 NA|NA|NA GL phosphoglycerate mutase MAG.T12.14_00308 469383.Cwoe_0617 8.4e-117 426.8 Actinobacteria 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 Bacteria 2I8G2@201174,COG0685@1,COG0685@2 NA|NA|NA E methylenetetrahydrofolate reductase (NAD(P)H) activity MAG.T12.14_00310 1035308.AQYY01000001_gene3477 7.2e-22 109.4 Bacteria Bacteria COG1357@1,COG1357@2 NA|NA|NA S protein homooligomerization MAG.T12.14_00311 196162.Noca_2810 1e-84 319.7 Propionibacteriales MA20_05015 Bacteria 2IHPD@201174,4DWVV@85009,COG0500@1,COG2226@2 NA|NA|NA Q Methyltransferase domain MAG.T12.14_00312 935866.JAER01000004_gene3859 6.6e-36 156.4 Propionibacteriales Bacteria 2E5NA@1,2IQ91@201174,330D3@2,4DRUP@85009 NA|NA|NA S Domain of unknown function (DUF4287) MAG.T12.14_00313 1380370.JIBA01000010_gene2372 4.1e-115 421.0 Bacteria Bacteria COG3832@1,COG3832@2 NA|NA|NA J glyoxalase III activity MAG.T12.14_00314 526225.Gobs_1399 9.3e-77 293.1 Frankiales ko:K19689 ko00000,ko01000,ko01002 Bacteria 2GJT9@201174,4ETFJ@85013,COG0640@1,COG0640@2 NA|NA|NA K Helix-turn-helix domain MAG.T12.14_00315 765420.OSCT_0070 2.8e-38 165.6 Chloroflexia Bacteria 28IZQ@1,2GA1E@200795,2Z8X1@2,377NY@32061 NA|NA|NA S Domain of unknown function (DUF4386) MAG.T12.14_00316 1133849.O3I_037875 3.1e-59 235.3 Nocardiaceae Bacteria 2HH54@201174,4G3S3@85025,COG1309@1,COG1309@2 NA|NA|NA K Tetracyclin repressor, C-terminal all-alpha domain MAG.T12.14_00317 391037.Sare_2910 3.5e-61 241.5 Actinobacteria Bacteria 2C7PT@1,2I886@201174,2ZCBY@2 NA|NA|NA MAG.T12.14_00318 593907.Celgi_2506 1.1e-96 359.8 Actinobacteria Bacteria 2GMD7@201174,COG1305@1,COG1305@2 NA|NA|NA E transglutaminase MAG.T12.14_00319 1246448.ANAZ01000005_gene5141 1.4e-106 392.9 Streptosporangiales Bacteria 2GIS3@201174,4EHU0@85012,COG0604@1,COG0604@2 NA|NA|NA C Zinc-binding dehydrogenase MAG.T12.14_00320 1246448.ANAZ01000044_gene1247 8.5e-82 310.1 Streptosporangiales Bacteria 2GV75@201174,4EK64@85012,COG1309@1,COG1309@2 NA|NA|NA K Tetracyclin repressor, C-terminal all-alpha domain MAG.T12.14_00321 1278308.KB907074_gene586 2.8e-38 165.2 Microbacteriaceae Bacteria 2IHZ7@201174,4FNK0@85023,COG0262@1,COG0262@2 NA|NA|NA H RibD C-terminal domain MAG.T12.14_00322 1120950.KB892768_gene5293 7.5e-29 133.7 Propionibacteriales crcB2 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 ko:K06199 ko00000,ko02000 1.A.43.1,1.A.43.2,1.A.43.3 Bacteria 2IKM1@201174,4DSBC@85009,COG0239@1,COG0239@2 NA|NA|NA D Important for reducing fluoride concentration in the cell, thus reducing its toxicity MAG.T12.14_00323 1068978.AMETH_3074 3e-43 181.0 Pseudonocardiales ko:K09137 ko00000 Bacteria 2IM7J@201174,4E77D@85010,COG1993@1,COG1993@2 NA|NA|NA S Uncharacterized ACR, COG1993 MAG.T12.14_00324 1386089.N865_12705 4.4e-35 154.1 Intrasporangiaceae crcB ko:K06199 ko00000,ko02000 1.A.43.1,1.A.43.2,1.A.43.3 Bacteria 2HGGD@201174,4FHJ1@85021,COG0239@1,COG0239@2 NA|NA|NA U Important for reducing fluoride concentration in the cell, thus reducing its toxicity MAG.T12.14_00326 1304865.JAGF01000001_gene77 3.6e-60 238.4 Actinobacteria Bacteria 2GTCV@201174,COG1595@1,COG1595@2 NA|NA|NA K Putative zinc-finger MAG.T12.14_00327 713586.KB900536_gene1549 1.3e-268 932.2 Chromatiales ilvD 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1259 Bacteria 1MUTQ@1224,1RMP2@1236,1WW0Q@135613,COG0129@1,COG0129@2 NA|NA|NA EG Belongs to the IlvD Edd family MAG.T12.14_00328 1121405.dsmv_0684 1.5e-21 111.7 Proteobacteria Bacteria 1NI9Y@1224,2EX2M@1,33QDR@2 NA|NA|NA MAG.T12.14_00329 84531.JMTZ01000014_gene2798 7.3e-32 145.6 Bacteria Bacteria 2EK9G@1,33DZS@2 NA|NA|NA MAG.T12.14_00331 1121405.dsmv_0678 2.7e-137 496.1 Proteobacteria Bacteria 1RFBU@1224,2C3RM@1,2Z9H1@2 NA|NA|NA MAG.T12.14_00332 84531.JMTZ01000014_gene2801 5.5e-152 545.0 Gammaproteobacteria Bacteria 1QVR5@1224,1T2HN@1236,2DBKT@1,2Z9V9@2 NA|NA|NA MAG.T12.14_00333 1116232.AHBF01000163_gene5903 1e-139 504.2 Actinobacteria Bacteria 28N6D@1,2HMGF@201174,2ZBB9@2 NA|NA|NA MAG.T12.14_00334 1449347.JQLN01000007_gene980 1.1e-49 203.8 Bacteria Bacteria COG4249@1,COG4249@2 NA|NA|NA S B-1 B cell differentiation MAG.T12.14_00336 369723.Strop_4549 6.3e-26 125.6 Micromonosporales Bacteria 2ATXZ@1,2GN21@201174,31JHI@2,4D910@85008 NA|NA|NA S Glycosyltransferase family 87 MAG.T12.14_00337 1298863.AUEP01000004_gene1929 3.6e-59 234.6 Propionibacteriales Bacteria 2GMV1@201174,4DQXT@85009,COG1846@1,COG1846@2 NA|NA|NA K Transcriptional regulator, MarR family MAG.T12.14_00338 196162.Noca_2052 3e-59 235.0 Propionibacteriales 1.5.1.40 ko:K06988 ko00000,ko01000 Bacteria 2GMZ5@201174,4DQQN@85009,COG2085@1,COG2085@2 NA|NA|NA S NADP oxidoreductase coenzyme F420-dependent MAG.T12.14_00339 1454010.JEOE01000004_gene180 4.7e-52 211.8 Actinobacteria ko:K02529 ko00000,ko03000 Bacteria 2GQER@201174,COG1609@1,COG1609@2 NA|NA|NA K PFAM regulatory protein LacI MAG.T12.14_00340 512565.AMIS_17490 2.1e-07 63.2 Micromonosporales Bacteria 2GJKC@201174,4DBA8@85008,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor MAG.T12.14_00341 1961.JOAK01000020_gene7292 1.2e-41 177.2 Actinobacteria Bacteria 2GN1H@201174,COG1680@1,COG1680@2 NA|NA|NA V Beta-lactamase MAG.T12.14_00342 1032480.MLP_51570 6.1e-101 374.0 Propionibacteriales ko:K07243 ko00000,ko02000 2.A.108.1,2.A.108.2 Bacteria 2GJ22@201174,4DPYF@85009,COG0672@1,COG0672@2 NA|NA|NA P Iron permease FTR1 family MAG.T12.14_00343 446469.Sked_28590 1.7e-138 499.6 Actinobacteria fruA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090582 2.7.1.202,2.7.1.56 ko:K00882,ko:K02768,ko:K02769,ko:K02770,ko:K11202 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273,M00306 R02071,R03232 RC00002,RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1 iEcSMS35_1347.EcSMS35_2314,iJN746.PP_0795,iSbBS512_1146.SbBS512_E0796 Bacteria 2GJU4@201174,COG1299@1,COG1299@2,COG1445@1,COG1445@2 NA|NA|NA GT Phosphotransferase System MAG.T12.14_00344 1068978.AMETH_4863 6.2e-36 157.1 Pseudonocardiales fruA 2.7.1.202 ko:K02768,ko:K02769,ko:K02770,ko:K02806 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273 R03232 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1 Bacteria 2IMPP@201174,4E3T9@85010,COG1762@1,COG1762@2 NA|NA|NA G Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 MAG.T12.14_00345 287986.DV20_35975 1.6e-75 289.7 Pseudonocardiales fruK GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006000,GO:0006001,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008443,GO:0008662,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019318,GO:0019320,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046835,GO:0071704,GO:1901575 2.7.1.11,2.7.1.56 ko:K00882,ko:K16370 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00345 R00756,R02071,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 iAF1260.b2168,iAPECO1_1312.APECO1_4386,iB21_1397.B21_02056,iEC042_1314.EC042_2401,iEC55989_1330.EC55989_2421,iECABU_c1320.ECABU_c24990,iECBD_1354.ECBD_1490,iECB_1328.ECB_02097,iECDH10B_1368.ECDH10B_2325,iECDH1ME8569_1439.ECDH1ME8569_2104,iECD_1391.ECD_02097,iECED1_1282.ECED1_2616,iECH74115_1262.ECH74115_3304,iECIAI1_1343.ECIAI1_2248,iECIAI39_1322.ECIAI39_2308,iECNA114_1301.ECNA114_2259,iECO103_1326.ECO103_2643,iECO111_1330.ECO111_2886,iECO26_1355.ECO26_3080,iECOK1_1307.ECOK1_2400,iECP_1309.ECP_2208,iECS88_1305.ECS88_2316,iECSE_1348.ECSE_2436,iECSF_1327.ECSF_2049,iECSP_1301.ECSP_3046,iECUMN_1333.ECUMN_2504,iECW_1372.ECW_m2369,iECs_1301.ECs3060,iEKO11_1354.EKO11_1586,iETEC_1333.ETEC_2303,iEcDH1_1363.EcDH1_1490,iEcHS_1320.EcHS_A2305,iEcSMS35_1347.EcSMS35_2315,iEcolC_1368.EcolC_1480,iG2583_1286.G2583_2711,iJO1366.b2168,iJR904.b2168,iLF82_1304.LF82_0744,iNRG857_1313.NRG857_11005,iPC815.YPO1299,iSBO_1134.SBO_2156,iSDY_1059.SDY_2316,iSFV_1184.SFV_2243,iSF_1195.SF2253,iSFxv_1172.SFxv_2486,iS_1188.S2382,iUMN146_1321.UM146_05955,iUMNK88_1353.UMNK88_2713,iUTI89_1310.UTI89_C2443,iWFL_1372.ECW_m2369,iY75_1357.Y75_RS11345,iZ_1308.Z3426,ic_1306.c2703 Bacteria 2GK7E@201174,4E1A9@85010,COG1105@1,COG1105@2 NA|NA|NA H Belongs to the carbohydrate kinase PfkB family MAG.T12.14_00346 28444.JODQ01000007_gene5740 1.7e-78 299.3 Streptosporangiales ko:K02081,ko:K03436 ko00000,ko03000 Bacteria 2GKWM@201174,4EHNG@85012,COG1349@1,COG1349@2 NA|NA|NA K DeoR C terminal sensor domain MAG.T12.14_00347 1504319.GM45_0745 1.6e-56 226.5 unclassified Actinobacteria (class) ko:K02029,ko:K02030 M00236 ko00000,ko00002,ko02000 3.A.1.3 Bacteria 2HFUI@201174,3UXRH@52018,COG0834@1,COG0834@2 NA|NA|NA ET Bacterial periplasmic substrate-binding proteins MAG.T12.14_00348 471852.Tcur_2117 5.5e-42 178.7 Streptosporangiales Bacteria 2GN1J@201174,4EJA0@85012,COG5650@1,COG5650@2 NA|NA|NA S Glycosyltransferase family 87 MAG.T12.14_00350 76636.JOEC01000002_gene2779 7.1e-15 85.9 Microbacteriaceae ko:K09946 ko00000 Bacteria 2GQUP@201174,4FQ8G@85023,COG3422@1,COG3422@2 NA|NA|NA S Domain of unknown function (DUF1508) MAG.T12.14_00351 1121272.KB903249_gene2195 4e-11 76.3 Micromonosporales Bacteria 2B1IP@1,2GT98@201174,31TZW@2,4DG21@85008 NA|NA|NA S RDD family MAG.T12.14_00352 397278.JOJN01000002_gene388 3e-19 101.3 Propionibacteriales lsr Bacteria 2C4MW@1,2IQ6A@201174,32RKK@2,4DRM6@85009 NA|NA|NA S Lsr2 MAG.T12.14_00353 1380354.JIAN01000008_gene3362 1.9e-29 136.7 Actinobacteria 3.2.1.91 ko:K19668 ko00500,ko01100,ko02020,map00500,map01100,map02020 R02886,R11308 RC00799 ko00000,ko00001,ko01000 GH6 Bacteria 2GN7G@201174,COG3291@1,COG3291@2,COG3420@1,COG3420@2 NA|NA|NA P PFAM PKD domain containing protein MAG.T12.14_00354 1043493.BBLU01000007_gene25 3.6e-191 674.5 Actinobacteria ugp 2.7.7.9 ko:K00963 ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130 M00129,M00361,M00362,M00549 R00289 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 2I2G3@201174,COG4284@1,COG4284@2 NA|NA|NA G UTP-glucose-1-phosphate uridylyltransferase MAG.T12.14_00355 1454010.JEOE01000011_gene2396 7.7e-129 468.0 Actinobacteria Bacteria 2IBWT@201174,COG4425@1,COG4425@2 NA|NA|NA S Alpha/beta-hydrolase family MAG.T12.14_00356 1304865.JAGF01000001_gene735 2.9e-118 431.8 Cellulomonadaceae ddhD Bacteria 2GKW0@201174,4F0TD@85016,COG0673@1,COG0673@2 NA|NA|NA S PFAM oxidoreductase domain protein MAG.T12.14_00357 1033730.CAHG01000016_gene637 5.8e-62 244.2 Propionibacteriales dsbA Bacteria 2GNBC@201174,4DQ7I@85009,COG2761@1,COG2761@2 NA|NA|NA Q DSBA-like thioredoxin domain MAG.T12.14_00358 43354.JOIJ01000011_gene2664 2.2e-120 439.9 Pseudonocardiales Bacteria 2GKI5@201174,4DYJ7@85010,COG1835@1,COG1835@2 NA|NA|NA I PFAM Acyltransferase MAG.T12.14_00359 314345.SPV1_05173 2.9e-95 355.9 Proteobacteria Bacteria 1NV1F@1224,COG2199@1,COG2199@2 NA|NA|NA T ggdef domain MAG.T12.14_00360 33898.JRHJ01000076_gene172 2.3e-45 188.3 Actinobacteria ko:K04750 ko00000 Bacteria 2IKY5@201174,COG2764@1,COG2764@2 NA|NA|NA S glyoxalase bleomycin resistance protein dioxygenase MAG.T12.14_00361 404589.Anae109_0594 1.1e-63 250.4 Deltaproteobacteria cyeA Bacteria 1MZQM@1224,2WRK6@28221,42VPN@68525,COG0697@1,COG0697@2 NA|NA|NA EG EamA-like transporter family MAG.T12.14_00365 935866.JAER01000071_gene1360 1e-90 340.1 Propionibacteriales fliA 2.7.11.1 ko:K02405,ko:K12132 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 ko00000,ko00001,ko01000,ko01001,ko02035,ko03021 Bacteria 2GKBK@201174,4DP9I@85009,COG1191@1,COG1191@2 NA|NA|NA K RNA polymerase, sigma 28 subunit, SigD FliA WhiG MAG.T12.14_00366 935866.JAER01000069_gene1411 5.7e-109 400.6 Propionibacteriales fliC ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 ko00000,ko00001,ko02035 Bacteria 2GUKT@201174,4DP5T@85009,COG1344@1,COG1344@2 NA|NA|NA N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella MAG.T12.14_00367 1298863.AUEP01000003_gene2841 1.4e-91 343.6 Propionibacteriales fliD GO:0001539,GO:0003674,GO:0005198,GO:0005575,GO:0005576,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009420,GO:0009421,GO:0009424,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588 ko:K02407 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 2IBVB@201174,4DP7F@85009,COG1345@1,COG1345@2 NA|NA|NA N Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end MAG.T12.14_00368 526225.Gobs_0983 7.6e-27 126.7 Frankiales fliS GO:0001539,GO:0003674,GO:0005198,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588 ko:K02422 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 2IRX7@201174,4ET7K@85013,COG1516@1,COG1516@2 NA|NA|NA N flagellar protein FliS MAG.T12.14_00370 196162.Noca_0762 7.2e-27 126.7 Propionibacteriales flgB ko:K02387 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 2IQWB@201174,4DUZX@85009,COG1815@1,COG1815@2 NA|NA|NA N Flagella basal body rod protein MAG.T12.14_00371 1298863.AUEP01000003_gene2837 4.8e-40 170.6 Propionibacteriales flgC GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009425,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588 ko:K02388 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 2IKRZ@201174,4DR9V@85009,COG1558@1,COG1558@2 NA|NA|NA N Flagellar basal body rod FlgEFG protein C-terminal MAG.T12.14_00372 196162.Noca_0760 1.2e-23 115.9 Propionibacteriales fliE GO:0005575,GO:0005623,GO:0009288,GO:0009425,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464 ko:K02408 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 2GR0F@201174,4DSFF@85009,COG1677@1,COG1677@2 NA|NA|NA NU Flagellar hook-basal body complex protein FliE MAG.T12.14_00373 1033730.CAHG01000006_gene1249 3.2e-135 488.8 Propionibacteriales fliF ko:K02409 ko02040,map02040 ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 Bacteria 2HG9F@201174,4DP5G@85009,COG1766@1,COG1766@2 NA|NA|NA NU Flagellar M-ring protein C-terminal MAG.T12.14_00374 1283287.KB822581_gene1476 9.8e-117 426.8 Propionibacteriales fliG GO:0001539,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006928,GO:0006935,GO:0006996,GO:0008150,GO:0009288,GO:0009425,GO:0009605,GO:0009987,GO:0016020,GO:0016043,GO:0022607,GO:0030030,GO:0030031,GO:0040011,GO:0042221,GO:0042330,GO:0042802,GO:0042803,GO:0042995,GO:0043226,GO:0043228,GO:0044085,GO:0044403,GO:0044419,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0044780,GO:0044781,GO:0046982,GO:0046983,GO:0048870,GO:0050896,GO:0051179,GO:0051674,GO:0051701,GO:0051704,GO:0052116,GO:0052126,GO:0052127,GO:0052143,GO:0052192,GO:0052195,GO:0052216,GO:0052243,GO:0070925,GO:0071840,GO:0071944,GO:0071973,GO:0071978,GO:0097588 ko:K02410 ko02030,ko02040,map02030,map02040 ko00000,ko00001,ko02035 Bacteria 2GP1H@201174,4DP5X@85009,COG1536@1,COG1536@2 NA|NA|NA N FliG N-terminal domain MAG.T12.14_00375 196162.Noca_0757 1.2e-22 113.6 Propionibacteriales fliH ko:K02411,ko:K03223 ko02040,ko03070,map02040,map03070 M00332,M00660 ko00000,ko00001,ko00002,ko02035,ko02044 3.A.6.1,3.A.6.2,3.A.6.3 Bacteria 2IRIT@201174,4DRP3@85009,COG1317@1,COG1317@2 NA|NA|NA NU Flagellar biosynthesis type III secretory pathway MAG.T12.14_00376 397278.JOJN01000001_gene2897 2e-170 605.5 Propionibacteriales fliI GO:0003674,GO:0005488,GO:0005515,GO:0042802 3.6.3.14 ko:K02412,ko:K03224 ko02040,ko03070,map02040,map03070 M00332,M00542,M00660 ko00000,ko00001,ko00002,ko01000,ko02035,ko02044 3.A.6.1,3.A.6.2,3.A.6.3 Bacteria 2GKGV@201174,4DPDQ@85009,COG1157@1,COG1157@2 NA|NA|NA NU ATP synthase alpha/beta family, nucleotide-binding domain MAG.T12.14_00377 935866.JAER01000042_gene2744 6.6e-14 84.0 Propionibacteriales Bacteria 2B1ES@1,2GT2Q@201174,31TVG@2,4DSCJ@85009 NA|NA|NA S Flagellar FliJ protein MAG.T12.14_00378 935866.JAER01000042_gene2745 5.6e-46 191.0 Propionibacteriales Bacteria 2GIWB@201174,4DPT1@85009,COG0741@1,COG0741@2,COG0791@1,COG0791@2 NA|NA|NA M NlpC/P60 family MAG.T12.14_00379 196162.Noca_0753 2.1e-19 103.6 Propionibacteriales fliK ko:K02414 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 2GVZ8@201174,4DS9X@85009,COG3144@1,COG3144@2 NA|NA|NA N Flagellar hook-length control protein FliK MAG.T12.14_00380 397278.JOJN01000001_gene2901 6.3e-30 137.1 Propionibacteriales flgD ko:K02389 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 2IQIQ@201174,4DS0Z@85009,COG1843@1,COG1843@2 NA|NA|NA N Flagellar hook capping protein - N-terminal region MAG.T12.14_00381 397278.JOJN01000001_gene2902 3.3e-110 404.8 Propionibacteriales flgG GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588 ko:K02390 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 2I3KN@201174,4DNCD@85009,COG4786@1,COG4786@2 NA|NA|NA N Flagellar basal body rod FlgEFG protein C-terminal MAG.T12.14_00382 196162.Noca_0750 1.4e-14 85.5 Propionibacteriales flbD ko:K02385 ko00000,ko02035 Bacteria 2GRTC@201174,4DVPB@85009,COG1582@1,COG1582@2 NA|NA|NA N Flagellar protein (FlbD) MAG.T12.14_00383 1283287.KB822581_gene1417 3.4e-98 364.8 Propionibacteriales motA ko:K02556 ko02020,ko02030,ko02040,map02020,map02030,map02040 ko00000,ko00001,ko02000,ko02035 1.A.30.1 Bacteria 2I92C@201174,4DP5S@85009,COG1291@1,COG1291@2 NA|NA|NA N MotA/TolQ/ExbB proton channel family MAG.T12.14_00384 1298863.AUEP01000003_gene2824 2.4e-79 302.4 Propionibacteriales motB ko:K02557 ko02030,ko02040,map02030,map02040 ko00000,ko00001,ko02000,ko02035 1.A.30.1 Bacteria 2IG81@201174,4DTTH@85009,COG1360@1,COG1360@2 NA|NA|NA N Membrane MotB of proton-channel complex MotA/MotB MAG.T12.14_00385 935866.JAER01000042_gene2752 8.2e-28 130.2 Propionibacteriales fliL ko:K02415 ko00000,ko02035 Bacteria 2ITFQ@201174,4DV67@85009,COG1580@1,COG1580@2 NA|NA|NA N Flagellar basal body-associated protein FliL MAG.T12.14_00386 1283287.KB822581_gene1414 2.6e-87 328.9 Propionibacteriales fliM ko:K02416,ko:K02417 ko02030,ko02040,map02030,map02040 ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 Bacteria 2ICP2@201174,4DNNZ@85009,COG1868@1,COG1868@2 NA|NA|NA N Flagellar motor switch protein FliM MAG.T12.14_00387 196162.Noca_0745 2.4e-35 156.0 Propionibacteriales fliN ko:K02417 ko02030,ko02040,map02030,map02040 ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 Bacteria 2IGHQ@201174,4DREH@85009,COG1886@1,COG1886@2 NA|NA|NA NU Type III flagellar switch regulator (C-ring) FliN C-term MAG.T12.14_00388 196162.Noca_0744 2.8e-20 105.1 Propionibacteriales fliP ko:K02418,ko:K02419 ko02040,map02040 ko00000,ko00001,ko02035,ko02044 3.A.6.2 Bacteria 2GREW@201174,4DVDJ@85009,COG3190@1,COG3190@2 NA|NA|NA N Flagellar biosynthesis protein, FliO MAG.T12.14_00389 935866.JAER01000042_gene2756 5.6e-74 285.0 Propionibacteriales fliP ko:K02419,ko:K03226 ko02040,ko03070,map02040,map03070 M00332,M00542,M00660 ko00000,ko00001,ko00002,ko02035,ko02044 3.A.6.1,3.A.6.2,3.A.6.3 Bacteria 2GP63@201174,4DPT8@85009,COG1338@1,COG1338@2 NA|NA|NA NU FliP family MAG.T12.14_00390 397278.JOJN01000001_gene2924 4.7e-31 140.2 Propionibacteriales fliQ ko:K02420 ko02040,map02040 ko00000,ko00001,ko02035,ko02044 3.A.6.2 Bacteria 2IQ8H@201174,4DRPB@85009,COG1987@1,COG1987@2 NA|NA|NA NU Bacterial export proteins, family 3 MAG.T12.14_00391 1298863.AUEP01000003_gene2817 5e-78 297.7 Propionibacteriales fliR ko:K02421,ko:K03228,ko:K13820 ko02040,ko03070,map02040,map03070 M00332,M00542,M00660 ko00000,ko00001,ko00002,ko02035,ko02044 3.A.6.1,3.A.6.2,3.A.6.3 Bacteria 2IDEX@201174,4DPR0@85009,COG1684@1,COG1684@2 NA|NA|NA NU Bacterial export proteins, family 1 MAG.T12.14_00392 1033730.CAHG01000007_gene2549 3e-117 428.7 Propionibacteriales flhB GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02401,ko:K02556,ko:K03229,ko:K04061,ko:K13820 ko02020,ko02030,ko02040,ko03070,map02020,map02030,map02040,map03070 M00332,M00542,M00660 ko00000,ko00001,ko00002,ko02000,ko02035,ko02044 1.A.30.1,3.A.6.1,3.A.6.2,3.A.6.3 Bacteria 2HF6J@201174,4DQ2U@85009,COG1377@1,COG1377@2 NA|NA|NA NU FlhB HrpN YscU SpaS Family MAG.T12.14_00393 1298863.AUEP01000003_gene2815 2.1e-259 901.7 Propionibacteriales flhA GO:0005575,GO:0005623,GO:0005886,GO:0006996,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0022607,GO:0030030,GO:0030031,GO:0044085,GO:0044464,GO:0044780,GO:0044781,GO:0070925,GO:0071840,GO:0071944 ko:K02400 ko02040,map02040 ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 Bacteria 2IB5S@201174,4DP8V@85009,COG1298@1,COG1298@2 NA|NA|NA NU Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin MAG.T12.14_00395 1283287.KB822581_gene1520 9.2e-23 112.5 Propionibacteriales csrA ko:K03563,ko:K13626 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 ko00000,ko00001,ko02035,ko03019 Bacteria 2GRPH@201174,4DS3Q@85009,COG1551@1,COG1551@2 NA|NA|NA T Global regulator protein family MAG.T12.14_00396 1298863.AUEP01000003_gene2847 4.4e-36 157.5 Propionibacteriales fliW ko:K13626 ko00000,ko02035 Bacteria 2GT61@201174,4DRPC@85009,COG1699@1,COG1699@2 NA|NA|NA S Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum MAG.T12.14_00397 196162.Noca_0770 6.9e-79 300.8 Propionibacteriales flgL GO:0005575,GO:0005576,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464 ko:K02397 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 2IA40@201174,4DNBS@85009,COG1344@1,COG1344@2 NA|NA|NA N Bacterial flagellin C-terminal helical region MAG.T12.14_00398 196162.Noca_0769 8.2e-127 460.7 Propionibacteriales flgK ko:K02396 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 2GNXQ@201174,4DNRW@85009,COG1256@1,COG1256@2 NA|NA|NA N Flagellar basal body rod FlgEFG protein C-terminal MAG.T12.14_00399 1298863.AUEP01000003_gene2844 2.8e-42 178.3 Propionibacteriales flgN Bacteria 2B12R@1,2IQ5J@201174,31TG8@2,4DRX1@85009 NA|NA|NA S FlgN protein MAG.T12.14_00401 1035308.AQYY01000001_gene2568 7.4e-264 916.4 Peptococcaceae glgB GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901576 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 ko00000,ko00001,ko00002,ko01000,ko04147 CBM48,GH13 Bacteria 1TP4M@1239,247WH@186801,260UV@186807,COG0296@1,COG0296@2 NA|NA|NA G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position MAG.T12.14_00402 649831.L083_4309 4.6e-33 147.9 Micromonosporales Bacteria 2IK2E@201174,4DIYC@85008,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family MAG.T12.14_00404 1150399.AQYK01000001_gene1603 1.8e-39 171.4 Microbacteriaceae yhgE ko:K01421 ko00000 Bacteria 2GKEM@201174,4FM86@85023,COG1511@1,COG1511@2 NA|NA|NA S YhgE Pip domain protein MAG.T12.14_00405 1150399.AQYK01000001_gene1604 1.3e-232 813.1 Microbacteriaceae ko:K06994 ko00000 Bacteria 2GJ5A@201174,4FK7G@85023,COG1033@1,COG1033@2,COG2409@1,COG2409@2 NA|NA|NA D MMPL family MAG.T12.14_00406 1463861.JNXE01000006_gene5743 9.2e-43 179.9 Actinobacteria furA ko:K03711,ko:K22297 ko00000,ko03000 Bacteria 2IFBR@201174,COG0735@1,COG0735@2 NA|NA|NA P Belongs to the Fur family MAG.T12.14_00407 134676.ACPL_8199 0.0 1103.6 Micromonosporales katG GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 Bacteria 2GJFP@201174,4D8UR@85008,COG0376@1,COG0376@2 NA|NA|NA P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity MAG.T12.14_00409 2045.KR76_07085 2.6e-31 142.1 Propionibacteriales VY92_09940 ko:K09796 ko00000,ko03110 Bacteria 2IR3D@201174,4DS2B@85009,COG2847@1,COG2847@2 NA|NA|NA S Copper chaperone PCu(A)C MAG.T12.14_00410 1179773.BN6_18910 6.3e-31 140.6 Pseudonocardiales XK27_02315 Bacteria 2IMR2@201174,4E5VC@85010,COG5646@1,COG5646@2 NA|NA|NA S Domain of unknown function (DU1801) MAG.T12.14_00411 1240349.ANGC01000051_gene4101 8.3e-148 530.4 Nocardiaceae Bacteria 2CA5R@1,2GM6V@201174,2Z81H@2,4FVE9@85025 NA|NA|NA MAG.T12.14_00412 1713.JOFV01000017_gene106 6.8e-41 173.3 Cellulomonadaceae ywzG Bacteria 2IQSE@201174,4F1CD@85016,COG1695@1,COG1695@2 NA|NA|NA K Transcriptional regulator PadR-like family MAG.T12.14_00413 590998.Celf_2836 3.5e-115 422.2 Cellulomonadaceae ydhC ko:K07552,ko:K18552 br01600,ko00000,ko01504,ko02000 2.A.1.2,2.A.1.2.3 Bacteria 2I2Q2@201174,4F0N0@85016,COG0477@1,COG0477@2 NA|NA|NA EGP TIGRFAM drug resistance transporter, Bcr CflA subfamily MAG.T12.14_00414 408672.NBCG_01925 1.2e-88 333.2 Propionibacteriales 3.2.1.83 ko:K20846 ko00000,ko01000 GH16 Bacteria 2GTJC@201174,4DQGW@85009,COG2273@1,COG2273@2 NA|NA|NA G Glycosyl hydrolases family 16 MAG.T12.14_00415 1120950.KB892775_gene1183 2e-127 462.6 Propionibacteriales arsB Bacteria 2GMQJ@201174,4DN5A@85009,COG1055@1,COG1055@2 NA|NA|NA P Bacterial Na+/H+ antiporter B (NhaB) MAG.T12.14_00416 710421.Mycch_1475 1.3e-96 359.4 Mycobacteriaceae ahpC 1.11.1.15 ko:K03386 ko04214,map04214 ko00000,ko00001,ko01000,ko04147 Bacteria 234SP@1762,2GM74@201174,COG0450@1,COG0450@2 NA|NA|NA O Alkyl hydroperoxide reductase MAG.T12.14_00417 526222.Desal_3467 1.7e-67 263.1 Desulfovibrionales Bacteria 1RAKG@1224,2MAVS@213115,2WN6A@28221,42QYD@68525,COG2199@1,COG3706@2 NA|NA|NA T Diguanylate cyclase, GGDEF domain MAG.T12.14_00418 937777.Deipe_2178 1.3e-29 137.9 Bacteria 3.4.21.107 ko:K04771,ko:K08372 ko01503,ko02020,map01503,map02020 M00728 ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 Bacteria COG0265@1,COG0265@2 NA|NA|NA O serine-type endopeptidase activity MAG.T12.14_00419 1035308.AQYY01000001_gene1812 2.1e-87 329.7 Bacteria Bacteria COG4325@1,COG4325@2 NA|NA|NA MAG.T12.14_00420 671143.DAMO_1527 9.4e-63 247.3 unclassified Bacteria yrbG ko:K07301 ko00000,ko02000 2.A.19.5 Bacteria 2NPPD@2323,COG0530@1,COG0530@2 NA|NA|NA P Sodium/calcium exchanger protein MAG.T12.14_00421 103733.JNYO01000019_gene2036 3.5e-119 434.9 Pseudonocardiales Bacteria 2C1EG@1,2GK4W@201174,2Z7MZ@2,4DZP1@85010 NA|NA|NA MAG.T12.14_00422 471853.Bcav_3980 5.6e-152 544.3 Actinobacteria Bacteria 2GJ8H@201174,COG3119@1,COG3119@2 NA|NA|NA P Pfam Sulfatase MAG.T12.14_00423 1035308.AQYY01000001_gene2432 9.1e-40 169.9 Clostridia Bacteria 1VQQ3@1239,255AM@186801,COG5646@1,COG5646@2 NA|NA|NA S Domain of unknown function (DU1801) MAG.T12.14_00424 882083.SacmaDRAFT_2733 1.2e-27 130.6 Pseudonocardiales crtY 1.14.19.49,5.5.1.19 ko:K06443,ko:K14257 ko00253,ko00404,ko00906,ko01057,ko01100,ko01110,ko01130,map00253,map00404,map00906,map01057,map01100,map01110,map01130 M00097,M00790,M00823 R03824,R04801,R05341,R05456,R06962,R07856,R11106,R11478 RC00949,RC01004,RC01964 ko00000,ko00001,ko00002,ko01000 Bacteria 2GNH7@201174,4E8RQ@85010,COG0644@1,COG0644@2 NA|NA|NA C Lycopene cyclase protein MAG.T12.14_00425 512565.AMIS_47840 5.5e-49 201.1 Bacteria 2.7.1.48 ko:K00876 ko00240,ko00983,ko01100,map00240,map00983,map01100 R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232 RC00002,RC00017 ko00000,ko00001,ko01000 Bacteria COG0572@1,COG0572@2 NA|NA|NA F uridine kinase MAG.T12.14_00426 1254432.SCE1572_09945 1.5e-70 274.6 Myxococcales Bacteria 1QX82@1224,2X86M@28221,2Z3M6@29,43CYG@68525,COG5555@1,COG5555@2 NA|NA|NA N FG-GAP repeat MAG.T12.14_00427 1386089.N865_17375 3.6e-82 312.0 Intrasporangiaceae ko:K06889 ko00000 Bacteria 2I0E5@201174,4FJN1@85021,COG1073@1,COG1073@2 NA|NA|NA S X-Pro dipeptidyl-peptidase (S15 family) MAG.T12.14_00428 931626.Awo_c04330 1.9e-14 85.9 Eubacteriaceae Bacteria 1TTZ1@1239,25HYR@186801,25XUE@186806,COG1846@1,COG1846@2 NA|NA|NA K Transcriptional regulator MAG.T12.14_00429 1379270.AUXF01000001_gene2074 7.7e-40 171.0 Gemmatimonadetes Bacteria 1ZTNA@142182,2ZA6T@2,arCOG10456@1 NA|NA|NA MAG.T12.14_00430 665577.JH993790_gene1709 4.3e-14 85.5 Actinobacteria Bacteria 2B5F3@1,2H0EX@201174,31Y9K@2 NA|NA|NA S Short C-terminal domain MAG.T12.14_00431 1123393.KB891317_gene2319 8.2e-68 263.5 Betaproteobacteria yiiE Bacteria 1R9WQ@1224,2VQBM@28216,COG3548@1,COG3548@2 NA|NA|NA S Protein of unknown function (DUF1211) MAG.T12.14_00432 408672.NBCG_02347 5.8e-27 127.9 Propionibacteriales rpoC Bacteria 2GKXN@201174,4DQPK@85009,COG0739@1,COG0739@2 NA|NA|NA M PFAM NLP P60 protein MAG.T12.14_00434 1206733.BAGC01000043_gene189 1.7e-62 246.5 Nocardiaceae ko:K07454 ko00000 Bacteria 2HHZ8@201174,4G1UT@85025,COG3440@1,COG3440@2 NA|NA|NA V HNH endonuclease MAG.T12.14_00435 298653.Franean1_0560 1.5e-26 124.8 Frankiales cspC ko:K03704 ko00000,ko03000 Bacteria 2GQRU@201174,4ETAA@85013,COG1278@1,COG1278@2 NA|NA|NA K Cold shock protein MAG.T12.14_00436 1120947.ATUX01000005_gene1328 1.4e-72 280.0 Actinobacteria ko:K01989,ko:K05832 M00247 ko00000,ko00002,ko02000 Bacteria 2GKNV@201174,4D55W@85005,COG2984@1,COG2984@2 NA|NA|NA S ABC transporter substrate binding protein MAG.T12.14_00437 574087.Acear_1446 1.2e-73 283.5 Halanaerobiales WQ51_06230 ko:K01989,ko:K05832,ko:K05833 M00247 ko00000,ko00002,ko02000 Bacteria 1TPDJ@1239,249P1@186801,3WA9B@53433,COG4120@1,COG4120@2 NA|NA|NA S PFAM Branched-chain amino acid transport system permease component MAG.T12.14_00438 411483.FAEPRAA2165_03445 3.6e-74 285.0 Ruminococcaceae ko:K05833 M00247 ko00000,ko00002,ko02000 Bacteria 1TPAN@1239,247WW@186801,3WHK4@541000,COG1101@1,COG1101@2 NA|NA|NA S Psort location CytoplasmicMembrane, score MAG.T12.14_00440 1504672.669787050 2.2e-11 75.9 Comamonadaceae Bacteria 1R95F@1224,28J0Q@1,2VJZ5@28216,2Z8XV@2,4A9RS@80864 NA|NA|NA MAG.T12.14_00441 1380370.JIBA01000015_gene318 2.6e-60 239.6 Intrasporangiaceae Bacteria 2GK3A@201174,4FFEB@85021,COG1680@1,COG1680@2 NA|NA|NA V Beta-lactamase MAG.T12.14_00442 1035308.AQYY01000002_gene896 1.2e-20 105.9 Bacteria Bacteria 2DNVN@1,32ZD5@2 NA|NA|NA S Lsr2 MAG.T12.14_00443 1150399.AQYK01000002_gene3209 3.8e-184 652.1 Microbacteriaceae Bacteria 2GN7G@201174,4FKX3@85023,COG3291@1,COG3291@2 NA|NA|NA G Repeats in polycystic kidney disease 1 (PKD1) and other proteins MAG.T12.14_00444 593907.Celgi_2417 1.8e-164 585.5 Cellulomonadaceae pfkA 2.7.1.11,2.7.1.90 ko:K00850,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 iJN678.pfkA Bacteria 2GK6W@201174,4F0UZ@85016,COG0205@1,COG0205@2 NA|NA|NA H Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis MAG.T12.14_00445 686340.Metal_2787 1.8e-134 486.1 Proteobacteria cpgS ko:K05716 R03298 RC00900 ko00000,ko01000 Bacteria 1MV4C@1224,COG2403@1,COG2403@2 NA|NA|NA S cyclic 2,3-diphosphoglycerate synthetase activity MAG.T12.14_00446 1304865.JAGF01000001_gene1186 2.2e-52 213.8 Actinobacteria Bacteria 2IAWA@201174,COG2199@1,COG2202@1,COG2202@2,COG3706@2 NA|NA|NA T diguanylate cyclase MAG.T12.14_00447 1463934.JOCF01000050_gene7607 3.5e-14 86.3 Actinobacteria 2.1.1.107 ko:K02303,ko:K22010 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121,M00839 R03194 RC00003,RC00871 ko00000,ko00001,ko00002,ko01000,ko02022 Bacteria 2H0E2@201174,COG2203@1,COG2203@2,COG3707@1,COG3707@2 NA|NA|NA T ANTAR MAG.T12.14_00448 1463936.JOJI01000077_gene65 2.3e-24 118.6 Actinobacteria Bacteria 2IBP1@201174,COG2207@1,COG2207@2 NA|NA|NA K transcriptional regulator MAG.T12.14_00450 1032480.MLP_04950 8.2e-53 214.2 Propionibacteriales tagH 3.1.3.5,3.1.3.6,3.1.4.16 ko:K01081,ko:K01119 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 R00183,R00511,R00963,R01126,R01227,R01562,R01569,R01664,R01877,R01968,R02088,R02102,R02148,R02323,R02370,R02719,R03346,R03537,R03538,R03929,R05135 RC00017,RC00078,RC00296 ko00000,ko00001,ko01000 Bacteria 2I3RJ@201174,4DR7V@85009,COG3103@1,COG3103@2 NA|NA|NA T sh3 domain protein MAG.T12.14_00451 1121017.AUFG01000019_gene2370 3e-56 226.5 Intrasporangiaceae ko:K14645 ko02024,map02024 ko00000,ko00001,ko01000,ko01002,ko03110 Bacteria 2GIRE@201174,4FGR4@85021,COG1404@1,COG1404@2 NA|NA|NA O Subtilase family MAG.T12.14_00452 1123322.KB904713_gene5220 1.8e-133 482.6 Actinobacteria 1.18.1.3,1.7.1.15 ko:K00362,ko:K00529 ko00071,ko00360,ko00910,ko01120,ko01220,map00071,map00360,map00910,map01120,map01220 M00530,M00545 R00787,R02000,R06782,R06783 RC00098,RC00176 br01602,ko00000,ko00001,ko00002,ko01000 Bacteria 2GJKT@201174,COG0446@1,COG0446@2 NA|NA|NA Q pyridine nucleotide-disulphide oxidoreductase MAG.T12.14_00453 1108045.GORHZ_125_00320 9.8e-187 659.8 Gordoniaceae 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 Bacteria 2GIUC@201174,4GBU2@85026,COG0318@1,COG0318@2 NA|NA|NA IQ AMP-binding enzyme C-terminal domain MAG.T12.14_00454 1283287.KB822581_gene1545 1.7e-23 117.1 Propionibacteriales 2.7.6.5 ko:K07816 ko00230,map00230 R00429 RC00002,RC00078 ko00000,ko00001,ko01000 Bacteria 2GKF8@201174,4DPS6@85009,COG2357@1,COG2357@2,COG4328@1,COG4328@2 NA|NA|NA Q Region found in RelA / SpoT proteins MAG.T12.14_00455 1254432.SCE1572_10845 1.6e-155 556.6 Myxococcales kup ko:K03549 ko00000,ko02000 2.A.72 Bacteria 1MUVH@1224,2WJEH@28221,2YXPN@29,42P5Y@68525,COG3158@1,COG3158@2 NA|NA|NA P Transport of potassium into the cell MAG.T12.14_00456 408672.NBCG_01400 3.3e-70 272.7 Propionibacteriales 3.2.1.26 ko:K01193 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00801,R00802,R02410,R03635,R03921,R06088 RC00028,RC00077 ko00000,ko00001,ko01000 GH32 Bacteria 2GJ9T@201174,4DS6H@85009,COG1621@1,COG1621@2 NA|NA|NA G Glycosyl hydrolases family 32 MAG.T12.14_00458 1305732.JAGG01000001_gene778 3.5e-16 91.3 Microbacteriaceae yidH ko:K00389 ko00000 Bacteria 2GQU9@201174,4FQ80@85023,COG2149@1,COG2149@2 NA|NA|NA S Domain of unknown function (DUF202) MAG.T12.14_00459 1380354.JIAN01000009_gene3760 1.4e-75 291.6 Actinobacteria Bacteria 2I8YV@201174,COG1652@1,COG1652@2 NA|NA|NA NU PFAM Peptidoglycan-binding LysM MAG.T12.14_00460 1463853.JOHW01000040_gene6696 8.1e-22 110.2 Actinobacteria Bacteria 2GRCJ@201174,COG4961@1,COG4961@2 NA|NA|NA U PFAM TadE family protein MAG.T12.14_00461 1380354.JIAN01000009_gene3757 5.9e-19 100.5 Bacteria Bacteria COG4961@1,COG4961@2 NA|NA|NA U PFAM TadE family protein MAG.T12.14_00463 1380354.JIAN01000009_gene3755 1e-50 207.2 Actinobacteria ko:K12510 ko00000,ko02044 Bacteria 2I2Z3@201174,COG4965@1,COG4965@2 NA|NA|NA U type II secretion system MAG.T12.14_00464 1380354.JIAN01000009_gene3754 6.5e-50 204.5 Actinobacteria Bacteria 2GN6E@201174,COG4965@1,COG4965@2 NA|NA|NA U type II secretion system MAG.T12.14_00465 1380354.JIAN01000009_gene3753 6.2e-133 480.7 Cellulomonadaceae ko:K02283 ko00000,ko02035,ko02044 Bacteria 2GKKJ@201174,4F10A@85016,COG4962@1,COG4962@2 NA|NA|NA U Type II/IV secretion system protein MAG.T12.14_00466 1449353.JQMQ01000005_gene5167 2.3e-25 122.9 Streptacidiphilus Bacteria 2HT5K@201174,2NF4C@228398,COG0455@1,COG0455@2 NA|NA|NA D bacterial-type flagellum organization MAG.T12.14_00467 1137268.AZXF01000033_gene3440 7.6e-26 124.4 Streptosporangiales Bacteria 2I6YM@201174,4ER8Y@85012,COG1261@1,COG1261@2 NA|NA|NA NO Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly MAG.T12.14_00468 1048339.KB913029_gene479 1.9e-27 129.8 Actinobacteria Bacteria 2F8QI@1,2H6TB@201174,3412U@2 NA|NA|NA MAG.T12.14_00470 1246445.ANAY01000013_gene117 3.8e-38 165.6 Streptosporangiales ykrP ko:K13663 ko00000,ko01000 Bacteria 2GJXP@201174,4EHTM@85012,COG3594@1,COG3594@2 NA|NA|NA G Acyltransferase family MAG.T12.14_00471 203119.Cthe_0110 6.1e-79 301.2 Ruminococcaceae hprK GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 ko:K06023 ko00000,ko01000 Bacteria 1TP5Z@1239,24999@186801,3WGB3@541000,COG1493@1,COG1493@2 NA|NA|NA H Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion MAG.T12.14_00472 1150399.AQYK01000001_gene1558 6.5e-43 181.0 Microbacteriaceae iphP 3.1.3.48,3.1.4.53 ko:K01104,ko:K03651 ko00230,ko02025,map00230,map02025 R00191 RC00296 ko00000,ko00001,ko01000 Bacteria 2GK28@201174,4FN9A@85023,COG2365@1,COG2365@2 NA|NA|NA T Tyrosine phosphatase family MAG.T12.14_00473 1291050.JAGE01000001_gene2582 2e-68 266.2 Ruminococcaceae hprK GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 ko:K06023 ko00000,ko01000 Bacteria 1TP5Z@1239,24999@186801,3WGB3@541000,COG1493@1,COG1493@2 NA|NA|NA H Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion MAG.T12.14_00474 1193181.BN10_1190010 4.9e-62 245.4 Intrasporangiaceae pepA ko:K08372 ko02020,map02020 ko00000,ko00001,ko01000,ko01002 Bacteria 2GJJ3@201174,4FJ5Z@85021,COG0265@1,COG0265@2 NA|NA|NA O Domain present in PSD-95, Dlg, and ZO-1/2. MAG.T12.14_00475 1229780.BN381_210036 1.3e-76 293.1 Actinobacteria Bacteria 2GJSF@201174,COG0500@1,COG2226@2 NA|NA|NA Q methyltransferase MAG.T12.14_00476 2002.JOEQ01000004_gene2898 5.6e-160 571.2 Streptosporangiales ko:K07114 ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 Bacteria 2GNSN@201174,4EH2B@85012,COG1840@1,COG1840@2,COG2304@1,COG2304@2 NA|NA|NA P von Willebrand factor type A domain MAG.T12.14_00477 35754.JNYJ01000005_gene5499 3.8e-09 68.9 Micromonosporales Bacteria 2FIZ9@1,2INWA@201174,34AQ2@2,4DIXT@85008 NA|NA|NA MAG.T12.14_00478 28042.GU90_04140 1.3e-58 233.0 Pseudonocardiales ko:K09019 ko00240,ko01100,map00240,map01100 R09289 RC00087 ko00000,ko00001,ko01000 Bacteria 2HC1J@201174,4DZB0@85010,COG0778@1,COG0778@2 NA|NA|NA C Nitroreductase family MAG.T12.14_00479 1003195.SCAT_1757 1.3e-226 793.1 Actinobacteria pepN 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 Bacteria 2GJJ4@201174,COG0308@1,COG0308@2 NA|NA|NA E aminopeptidase N MAG.T12.14_00480 590998.Celf_3362 4.2e-42 178.3 Cellulomonadaceae litS ko:K03088 ko00000,ko03021 Bacteria 2IKQ7@201174,4F2I1@85016,COG1595@1,COG1595@2 NA|NA|NA K TIGRFAM RNA polymerase sigma factor, sigma-70 family MAG.T12.14_00481 590998.Celf_3363 5.3e-35 154.8 Cellulomonadaceae Bacteria 2IM7X@201174,4F2HP@85016,COG5343@1,COG5343@2 NA|NA|NA S Anti-sigma-K factor rskA MAG.T12.14_00482 1385520.N802_03820 8.2e-53 213.8 Intrasporangiaceae ko:K19519 ko00000,ko04516 Bacteria 2IHKV@201174,4FGQK@85021,COG2335@1,COG2335@2 NA|NA|NA M Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. MAG.T12.14_00483 1121899.Q764_09130 2.4e-22 111.3 Flavobacterium Bacteria 1I3HF@117743,2NX4C@237,4NSVZ@976,COG2314@1,COG2314@2 NA|NA|NA S Pfam TM2 domain MAG.T12.14_00484 1035308.AQYY01000001_gene3393 2.2e-160 572.0 Peptococcaceae tgt 2.4.2.29 ko:K00773 R03789,R10209 RC00063 ko00000,ko01000,ko03016 Bacteria 1TNZ4@1239,247NJ@186801,260AS@186807,COG0343@1,COG0343@2 NA|NA|NA F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) MAG.T12.14_00485 479431.Namu_3445 4.5e-69 268.1 Actinobacteria 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 Bacteria 2GW7W@201174,COG3001@1,COG3001@2 NA|NA|NA G Fructosamine kinase MAG.T12.14_00486 1504319.GM45_0280 4.1e-71 274.6 unclassified Actinobacteria (class) yhhQ ko:K09125 ko00000 Bacteria 2IFDB@201174,3UX0S@52018,COG1738@1,COG1738@2 NA|NA|NA U Involved in the import of queuosine (Q) precursors, required for Q precursor salvage MAG.T12.14_00487 309800.C498_16184 4.8e-40 171.4 Halobacteria Archaea 23WKG@183963,2XXWE@28890,arCOG13341@1,arCOG13341@2157 NA|NA|NA MAG.T12.14_00488 1043493.BBLU01000006_gene2218 1.3e-57 230.3 Actinobacteria Bacteria 2I8IC@201174,COG2334@1,COG2334@2 NA|NA|NA EGP Major facilitator Superfamily MAG.T12.14_00489 102129.Lepto7375DRAFT_2915 1e-54 219.9 Oscillatoriales apt 2.4.2.7 ko:K00759 ko00230,ko01100,map00230,map01100 R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko04147 Bacteria 1G508@1117,1HAKH@1150,COG0503@1,COG0503@2 NA|NA|NA F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis MAG.T12.14_00491 1229780.BN381_130301 6.6e-50 204.1 unclassified Actinobacteria (class) plsC2 Bacteria 2IDC7@201174,3UXB2@52018,COG0204@1,COG0204@2 NA|NA|NA I Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T12.14_00492 1283283.ATXA01000013_gene3448 1.7e-66 259.6 Frankiales Bacteria 2GN5D@201174,4ESH4@85013,COG1305@1,COG1305@2 NA|NA|NA E Bacterial transglutaminase-like N-terminal region MAG.T12.14_00493 397278.JOJN01000019_gene2352 8.8e-45 187.6 Propionibacteriales MA20_32425 Bacteria 2GN0T@201174,4DP16@85009,COG2307@1,COG2307@2 NA|NA|NA S A predicted alpha-helical domain with a conserved ER motif. MAG.T12.14_00494 298654.FraEuI1c_4843 7.7e-177 627.1 Frankiales gcs2 Bacteria 2GN0J@201174,4ES9X@85013,COG2308@1,COG2308@2 NA|NA|NA S Circularly permuted ATP-grasp type 2 MAG.T12.14_00495 926550.CLDAP_11630 1.5e-26 126.7 Bacteria 3.1.3.3 ko:K07315 ko00000,ko01000,ko03021 Bacteria COG2452@1,COG2452@2,COG4936@1,COG4936@2 NA|NA|NA KT Sensory domain found in PocR MAG.T12.14_00496 1304865.JAGF01000001_gene3099 1.1e-64 254.2 Actinobacteria 1.8.5.4 ko:K17218 ko00920,map00920 R10152 RC03155 ko00000,ko00001,ko01000 Bacteria 2GRTN@201174,COG0446@1,COG0446@2 NA|NA|NA P pyridine nucleotide-disulphide oxidoreductase MAG.T12.14_00497 85643.Tmz1t_2231 8.6e-178 629.8 Rhodocyclales casC ko:K19124 ko00000,ko02048 Bacteria 1MVNH@1224,2KYSV@206389,2VP5P@28216,COG1857@1,COG1857@2 NA|NA|NA L CT1975-like protein MAG.T12.14_00499 1137269.AZWL01000042_gene1229 4e-37 162.2 Actinobacteria Bacteria 2DVVA@1,2IHH0@201174,32V07@2 NA|NA|NA MAG.T12.14_00500 1121372.AULK01000004_gene1325 1.2e-21 111.3 Microbacteriaceae Bacteria 2GU7G@201174,4FMTP@85023,COG1403@1,COG1403@2 NA|NA|NA V Domain of unknown function (DUF222) MAG.T12.14_00501 219305.MCAG_00437 5.8e-201 707.2 Micromonosporales pgi GO:0003674,GO:0003824,GO:0004347,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GJG0@201174,4DBW4@85008,COG0166@1,COG0166@2 NA|NA|NA G Belongs to the GPI family MAG.T12.14_00502 446468.Ndas_1544 8.1e-142 510.4 Streptosporangiales cysS GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010125,GO:0010126,GO:0010467,GO:0016020,GO:0016070,GO:0016137,GO:0016138,GO:0016874,GO:0016875,GO:0016879,GO:0016880,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035446,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.1.1.16,6.3.1.13 ko:K01883,ko:K15526 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iNJ661.Rv2130c Bacteria 2GJZR@201174,4EH1Y@85012,COG0215@1,COG0215@2 NA|NA|NA J Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins MAG.T12.14_00503 591157.SSLG_01071 2.1e-31 142.9 Actinobacteria surf1 ko:K14998 ko00000,ko03029 3.D.4.8 Bacteria 2GR90@201174,COG3346@1,COG3346@2 NA|NA|NA S SURF1-like protein MAG.T12.14_00504 1035308.AQYY01000002_gene664 2.7e-32 145.6 Bacteria Bacteria COG5274@1,COG5274@2 NA|NA|NA C heme binding MAG.T12.14_00505 1120950.KB892747_gene3703 1.1e-66 260.0 Propionibacteriales 3.1.3.10 ko:K07025,ko:K20866 ko00010,ko01120,map00010,map01120 R00947 RC00078 ko00000,ko00001,ko01000 Bacteria 2HZ7F@201174,4DQFA@85009,COG1011@1,COG1011@2 NA|NA|NA S HAD-superfamily hydrolase, subfamily IA, variant 1 MAG.T12.14_00506 479431.Namu_2200 5.4e-240 837.0 Frankiales proS GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 2GJ9G@201174,4ERXH@85013,COG0442@1,COG0442@2 NA|NA|NA J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS MAG.T12.14_00507 66377.JOBH01000024_gene3357 1.7e-79 302.8 Actinobacteria ko:K06976 ko00000 Bacteria 2GMD2@201174,COG3393@1,COG3393@2 NA|NA|NA S acetyltransferase MAG.T12.14_00508 1121861.KB899946_gene3939 3.9e-86 325.1 Rhodospirillales adhA 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 Bacteria 1MUTT@1224,2JR9U@204441,2TTI9@28211,COG1064@1,COG1064@2 NA|NA|NA S Alcohol dehydrogenase GroES-like domain MAG.T12.14_00510 1306174.JODP01000021_gene193 2.9e-101 375.6 Actinobacteria ko:K06946 ko00000 Bacteria 2IES1@201174,COG3596@1,COG3596@2,COG3597@1,COG3597@2 NA|NA|NA D Domain of unknown function (DUF697) MAG.T12.14_00511 40571.JOEA01000017_gene507 2.2e-178 631.7 Pseudonocardiales ispG GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009055,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0022900,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS06430,iJN678.gcpE Bacteria 2GK2S@201174,4DZX0@85010,COG0821@1,COG0821@2 NA|NA|NA I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate MAG.T12.14_00512 1123052.AUDF01000012_gene812 4.6e-26 125.2 Microbacteriaceae ko:K07090 ko00000 Bacteria 2I5VT@201174,4FNYV@85023,COG0730@1,COG0730@2 NA|NA|NA S Sulfite exporter TauE/SafE MAG.T12.14_00513 1386089.N865_16260 1.7e-100 373.2 Intrasporangiaceae rseP ko:K11749 ko02024,ko04112,map02024,map04112 ko00000,ko00001,ko01000,ko01002 Bacteria 2GJJT@201174,4FEQK@85021,COG0750@1,COG0750@2 NA|NA|NA M Peptidase family M50 MAG.T12.14_00514 471852.Tcur_3372 7.5e-137 493.8 Streptosporangiales dxr GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0050897,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 iAPECO1_1312.APECO1_1814,iECOK1_1307.ECOK1_0174,iECS88_1305.ECS88_0183,iHN637.CLJU_RS06420,iNJ661.Rv2870c,iUMN146_1321.UM146_23670,iUTI89_1310.UTI89_C0188 Bacteria 2GIRV@201174,4EGGZ@85012,COG0743@1,COG0743@2 NA|NA|NA I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) MAG.T12.14_00515 105422.BBPM01000100_gene5239 3.5e-181 641.3 Streptacidiphilus 1.2.1.3,1.2.1.9 ko:K00128,ko:K00131 ko00010,ko00030,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130,map01200 M00135,M00308,M00633 R00264,R00631,R00710,R00904,R01058,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIWZ@201174,2NG4B@228398,COG1012@1,COG1012@2 NA|NA|NA C Aldehyde dehydrogenase family MAG.T12.14_00516 1380347.JNII01000005_gene3136 2.1e-180 638.6 Frankiales gabT 2.6.1.19,2.6.1.22 ko:K00823,ko:K07250 ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648,R04188 RC00006,RC00062,RC00160 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 2GIS9@201174,4ERVR@85013,COG0160@1,COG0160@2 NA|NA|NA E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family MAG.T12.14_00517 521045.Kole_0725 1.9e-53 216.9 Thermotogae hemN1 Bacteria 2GDT0@200918,COG0635@1,COG0635@2 NA|NA|NA C Elongator protein 3, MiaB family, Radical SAM MAG.T12.14_00518 1449058.JQKT01000007_gene1901 2.3e-170 605.1 Microbacteriaceae lys1 Bacteria 2GMQ1@201174,4FKWT@85023,COG1748@1,COG1748@2 NA|NA|NA E Saccharopine dehydrogenase C-terminal domain MAG.T12.14_00519 1487953.JMKF01000043_gene2606 2.7e-25 122.1 Cyanobacteria ko:K03712 ko00000,ko03000 Bacteria 1G8VK@1117,COG1846@1,COG1846@2 NA|NA|NA K helix_turn_helix multiple antibiotic resistance protein MAG.T12.14_00521 1454010.JEOE01000007_gene2007 2.1e-85 322.8 Cellulomonadaceae 2.8.1.7,4.4.1.16 ko:K03980,ko:K11717 ko00450,ko01100,map00450,map01100 R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000,ko01011,ko02000 2.A.66.4 Bacteria 2I44K@201174,4F1AQ@85016,COG3266@1,COG3266@2 NA|NA|NA S domain, Protein MAG.T12.14_00522 479435.Kfla_1695 1e-218 766.1 Propionibacteriales mmsA 1.2.1.18,1.2.1.27 ko:K00140 ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200 M00013 R00705,R00706,R00922,R00935 RC00004,RC02723,RC02817 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJI2@201174,4DNVW@85009,COG1012@1,COG1012@2 NA|NA|NA C Aldehyde dehydrogenase family MAG.T12.14_00523 1157637.KB892115_gene4645 1.1e-158 566.6 Actinobacteria Bacteria 2GJQ9@201174,COG0665@1,COG0665@2 NA|NA|NA E FAD dependent oxidoreductase MAG.T12.14_00524 570268.ANBB01000037_gene2671 5e-57 229.2 Streptosporangiales Bacteria 2GIV0@201174,4EM8V@85012,COG0515@1,COG0515@2 NA|NA|NA KLT SMART serine threonine protein kinase MAG.T12.14_00525 106370.Francci3_3577 1.3e-15 90.5 Frankiales rlmN GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 ko:K06941 ko00000,ko01000,ko03009 Bacteria 2GJ48@201174,4ERPT@85013,COG0820@1,COG0820@2 NA|NA|NA J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs MAG.T12.14_00526 1504319.GM45_4540 3e-95 355.1 unclassified Actinobacteria (class) potC ko:K11070 ko02010,map02010 M00299 ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 Bacteria 2GJ6Q@201174,3UWPB@52018,COG1177@1,COG1177@2 NA|NA|NA P COG1177 ABC-type spermidine putrescine transport system, permease component II MAG.T12.14_00527 1504319.GM45_4535 6.2e-99 367.5 unclassified Actinobacteria (class) potH ko:K11071 ko02010,map02010 M00299 ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 Bacteria 2GJ5G@201174,3UWG9@52018,COG1176@1,COG1176@2 NA|NA|NA P COG1176 ABC-type spermidine putrescine transport system, permease component I MAG.T12.14_00528 105420.BBPO01000072_gene4006 5e-133 481.1 Streptacidiphilus potA 3.6.3.31 ko:K11072 ko02010,map02010 M00299 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.11.1 Bacteria 2GJCM@201174,2NG9M@228398,COG3842@1,COG3842@2 NA|NA|NA E TOBE domain MAG.T12.14_00529 1504319.GM45_4525 2.3e-117 429.1 unclassified Actinobacteria (class) ko:K11069 ko02010,map02010 M00299 ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 Bacteria 2GKVG@201174,3UWJS@52018,COG0687@1,COG0687@2 NA|NA|NA E Bacterial extracellular solute-binding protein MAG.T12.14_00530 37919.EP51_00995 9.7e-195 686.4 Nocardiaceae 1.2.1.8 ko:K00130 ko00260,ko01100,map00260,map01100 M00555 R02565,R02566 RC00080 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIWZ@201174,4FTXB@85025,COG1012@1,COG1012@2 NA|NA|NA C Belongs to the aldehyde dehydrogenase family MAG.T12.14_00531 1396141.BATP01000059_gene2437 3.4e-104 385.2 Verrucomicrobiae ldhA 1.1.1.28 ko:K03778 ko00620,ko01120,map00620,map01120 R00704 RC00044 ko00000,ko00001,ko01000 Bacteria 2ITY0@203494,46SGM@74201,COG1052@1,COG1052@2 NA|NA|NA CH D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain MAG.T12.14_00532 526225.Gobs_1721 1.9e-211 741.9 Frankiales 1.2.1.8 ko:K00130 ko00260,ko01100,map00260,map01100 M00555 R02565,R02566 RC00080 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIWZ@201174,4ERRA@85013,COG1012@1,COG1012@2 NA|NA|NA C Belongs to the aldehyde dehydrogenase family MAG.T12.14_00533 1380354.JIAN01000007_gene161 2e-59 235.3 Actinobacteria asnC ko:K03718 ko00000,ko03000 Bacteria 2GP1P@201174,COG1522@1,COG1522@2 NA|NA|NA K AsnC family MAG.T12.14_00534 1380370.JIBA01000014_gene1864 5e-209 733.8 Intrasporangiaceae bioA Bacteria 2GKF6@201174,4FE6A@85021,COG0161@1,COG0161@2 NA|NA|NA H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family MAG.T12.14_00535 367299.JOEE01000004_gene1059 4.1e-44 184.9 Intrasporangiaceae ko:K07005 ko00000 Bacteria 2GJ76@201174,4FGDI@85021,COG3467@1,COG3467@2 NA|NA|NA S Pyridoxamine 5'-phosphate oxidase MAG.T12.14_00536 219305.MCAG_03785 2.7e-162 578.6 Micromonosporales Bacteria 2GJQ9@201174,4DCEF@85008,COG0665@1,COG0665@2 NA|NA|NA E Glycine D-amino acid oxidases (deaminating) MAG.T12.14_00537 1121877.JQKF01000002_gene1657 1.7e-263 916.0 Acidimicrobiia putA 1.2.1.88,1.5.5.2 ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 Bacteria 2GM5R@201174,4CNNB@84992,COG0506@1,COG0506@2,COG1012@1,COG1012@2 NA|NA|NA CE Proline dehydrogenase MAG.T12.14_00538 235985.BBPN01000048_gene8264 8e-78 297.4 Streptacidiphilus tesB GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016042,GO:0016054,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042802,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046483,GO:0047617,GO:0051186,GO:0055086,GO:0071704,GO:0072329,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901575 ko:K10805 ko01040,map01040 ko00000,ko00001,ko01000,ko01004 iAF1260.b0452,iB21_1397.B21_00408,iBWG_1329.BWG_0334,iEC55989_1330.EC55989_0466,iECBD_1354.ECBD_3203,iECB_1328.ECB_00404,iECDH10B_1368.ECDH10B_0408,iECDH1ME8569_1439.ECDH1ME8569_0437,iECD_1391.ECD_00404,iECH74115_1262.ECH74115_0541,iECIAI1_1343.ECIAI1_0456,iECIAI39_1322.ECIAI39_0221,iECO103_1326.ECO103_0429,iECO111_1330.ECO111_0485,iECO26_1355.ECO26_0487,iECSE_1348.ECSE_0478,iECSP_1301.ECSP_0520,iECUMN_1333.ECUMN_0492,iECW_1372.ECW_m0524,iECs_1301.ECs0506,iEKO11_1354.EKO11_3394,iETEC_1333.ETEC_0505,iEcDH1_1363.EcDH1_3157,iEcE24377_1341.EcE24377A_0488,iEcHS_1320.EcHS_A0529,iEcSMS35_1347.EcSMS35_0496,iEcolC_1368.EcolC_3163,iG2583_1286.G2583_0564,iJO1366.b0452,iSSON_1240.SSON_0440,iUMNK88_1353.UMNK88_505,iWFL_1372.ECW_m0524,iY75_1357.Y75_RS02335,iZ_1308.Z0564,ic_1306.c0571 Bacteria 2GJ1B@201174,2NEH9@228398,COG1946@1,COG1946@2 NA|NA|NA I Acyl-CoA thioesterase MAG.T12.14_00539 1035308.AQYY01000001_gene1460 0.0 1702.6 Bacteria 4.1.1.38 ko:K20370 ko00620,ko01100,map00620,map01100 R00346 RC02741 ko00000,ko00001,ko01000 Bacteria 28HY3@1,2Z83I@2 NA|NA|NA S phosphoenolpyruvate carboxykinase (diphosphate) activity MAG.T12.14_00540 266940.Krad_1420 3.5e-147 528.1 Actinobacteria rlmN GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 ko:K06941 ko00000,ko01000,ko03009 Bacteria 2GJ48@201174,COG0820@1,COG0820@2 NA|NA|NA J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs MAG.T12.14_00541 65497.JODV01000002_gene4222 1.5e-70 273.1 Pseudonocardiales cdsA GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.41,2.7.7.67 ko:K00981,ko:K07098,ko:K19664 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799,R08966 RC00002 ko00000,ko00001,ko00002,ko01000 iLJ478.TM1397 Bacteria 2I7ZA@201174,4DYTX@85010,COG0575@1,COG0575@2 NA|NA|NA I Belongs to the CDS family MAG.T12.14_00542 1123320.KB889675_gene4071 1.4e-69 269.2 Actinobacteria frr GO:0002181,GO:0002184,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0030312,GO:0032984,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02838 ko00000,ko03012 Bacteria 2GJ9J@201174,COG0233@1,COG0233@2 NA|NA|NA J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another MAG.T12.14_00543 1123320.KB889675_gene4072 2.9e-100 371.7 Actinobacteria pyrH GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006225,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009163,GO:0009165,GO:0009185,GO:0009188,GO:0009193,GO:0009194,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0033862,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042455,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046048,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046872,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 R00158 RC00002 ko00000,ko00001,ko01000 iSB619.SA_RS06240 Bacteria 2GKWQ@201174,COG0528@1,COG0528@2 NA|NA|NA F Catalyzes the reversible phosphorylation of UMP to UDP MAG.T12.14_00544 446462.Amir_5910 1e-84 320.1 Pseudonocardiales tsf GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0030312,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02357 ko00000,ko03012,ko03029 Bacteria 2GK4M@201174,4DXP8@85010,COG0264@1,COG0264@2 NA|NA|NA J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome MAG.T12.14_00545 1123322.KB904679_gene3221 3.6e-115 421.4 Actinobacteria rpsB GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02967 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GMYC@201174,COG0052@1,COG0052@2 NA|NA|NA J Belongs to the universal ribosomal protein uS2 family MAG.T12.14_00546 570268.ANBB01000022_gene5213 9.7e-31 140.6 Streptosporangiales Bacteria 2IQ64@201174,4EJY5@85012,COG0739@1,COG0739@2 NA|NA|NA M Peptidase family M23 MAG.T12.14_00547 351607.Acel_1546 3.7e-93 348.2 Frankiales sigD ko:K02405 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 ko00000,ko00001,ko02035,ko03021 Bacteria 2GKBK@201174,4ERYG@85013,COG1191@1,COG1191@2 NA|NA|NA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released MAG.T12.14_00548 397278.JOJN01000001_gene2687 3.3e-92 345.1 Propionibacteriales xerC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03733,ko:K04763 ko00000,ko03036 Bacteria 2GNDP@201174,4DN7T@85009,COG4974@1,COG4974@2 NA|NA|NA L Belongs to the 'phage' integrase family. XerC subfamily MAG.T12.14_00549 1386089.N865_10205 5.4e-78 298.1 Intrasporangiaceae dprA 5.99.1.2 ko:K03168,ko:K04096 ko00000,ko01000,ko03032,ko03400 Bacteria 2GKDA@201174,4FEJX@85021,COG0758@1,COG0758@2 NA|NA|NA LU Rossmann fold nucleotide-binding protein involved in DNA uptake MAG.T12.14_00550 1043493.BBLU01000010_gene217 1.2e-121 443.7 Actinobacteria ko:K07391 ko00000 Bacteria 2GJIQ@201174,COG0606@1,COG0606@2 NA|NA|NA O PFAM magnesium chelatase ChlI subunit MAG.T12.14_00551 1120950.KB892769_gene5382 1.9e-27 128.6 Propionibacteriales yraN ko:K07460 ko00000 Bacteria 2IQ3X@201174,4DRQN@85009,COG0792@1,COG0792@2 NA|NA|NA L Belongs to the UPF0102 family MAG.T12.14_00552 1156935.QWE_02920 3.7e-60 238.4 Rhizobiaceae sfuB ko:K02011 ko02010,map02010 M00190 ko00000,ko00001,ko00002,ko02000 3.A.1.10 Bacteria 1MWEV@1224,2VEX7@28211,4BETJ@82115,COG1178@1,COG1178@2 NA|NA|NA P ABC-type Fe3 transport system, permease component MAG.T12.14_00553 106370.Francci3_3562 3.6e-199 701.0 Frankiales infB ko:K02519 ko00000,ko03012,ko03029 Bacteria 2GKPH@201174,4ERI2@85013,COG0532@1,COG0532@2 NA|NA|NA J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex MAG.T12.14_00554 591158.SSMG_04921 1.4e-28 132.1 Actinobacteria ylxP ko:K09764 ko00000 Bacteria 2IQW4@201174,COG1550@1,COG1550@2 NA|NA|NA S protein conserved in bacteria MAG.T12.14_00555 479433.Caci_7740 3.1e-49 201.4 Actinobacteria rbfA ko:K02834 ko00000,ko03009 Bacteria 2IKXP@201174,COG0858@1,COG0858@2 NA|NA|NA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA MAG.T12.14_00556 1304865.JAGF01000001_gene3790 1.1e-79 303.5 Cellulomonadaceae truB GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 ko:K03177 ko00000,ko01000,ko03016 Bacteria 2GJZK@201174,4F0NH@85016,COG0130@1,COG0130@2 NA|NA|NA J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs MAG.T12.14_00557 1283283.ATXA01000005_gene2038 3.8e-156 558.1 Frankiales pepP 3.4.11.9 ko:K01262 ko00000,ko01000,ko01002 Bacteria 2GM7D@201174,4ERTK@85013,COG0006@1,COG0006@2 NA|NA|NA E Creatinase/Prolidase N-terminal domain MAG.T12.14_00558 591157.SSLG_04999 2.9e-75 288.9 Actinobacteria ribF GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008531,GO:0009058,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009124,GO:0009156,GO:0009161,GO:0009165,GO:0009231,GO:0009259,GO:0009260,GO:0009398,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0034654,GO:0042364,GO:0042726,GO:0042727,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046390,GO:0046444,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKQF@201174,COG0196@1,COG0196@2 NA|NA|NA H Belongs to the ribF family MAG.T12.14_00559 28444.JODQ01000001_gene2722 1.6e-34 151.8 Streptosporangiales rpsO GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006378,GO:0006396,GO:0006397,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016071,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031123,GO:0031124,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043631,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02956 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IQA0@201174,4EK2G@85012,COG0184@1,COG0184@2 NA|NA|NA J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome MAG.T12.14_00560 566461.SSFG_02009 0.0 1146.0 Actinobacteria pnp GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 Bacteria 2GIT2@201174,COG1185@1,COG1185@2 NA|NA|NA J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction MAG.T12.14_00561 1123320.KB889675_gene4004 1.3e-142 513.1 Actinobacteria pepR GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 2GJZ3@201174,COG0612@1,COG0612@2 NA|NA|NA S Belongs to the peptidase M16 family MAG.T12.14_00562 110319.CF8_2787 2.4e-85 322.0 Propionibacteriales dapB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0055114,GO:0070402,GO:0070404,GO:0071704,GO:0071944,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 iJN678.dapB,iNJ661.Rv2773c,iYO844.BSU22490 Bacteria 2GM2T@201174,4DNG2@85009,COG0289@1,COG0289@2 NA|NA|NA E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate MAG.T12.14_00563 223184.AS25_06030 8.4e-33 146.7 Micrococcaceae Bacteria 1W9QW@1268,2IFHE@201174,COG5010@1,COG5010@2 NA|NA|NA U COG0457 FOG TPR repeat MAG.T12.14_00564 105420.BBPO01000052_gene1853 1.2e-29 136.7 Streptacidiphilus Bacteria 2H3AT@201174,2NGQ3@228398,COG3247@1,COG3247@2 NA|NA|NA S Short repeat of unknown function (DUF308) MAG.T12.14_00565 1123487.KB892846_gene459 1.8e-108 399.1 Proteobacteria supH Bacteria 1Q5HK@1224,COG0561@1,COG0561@2 NA|NA|NA C Hydrolase MAG.T12.14_00566 187303.BN69_3335 1e-55 224.2 Alphaproteobacteria GO:0003674,GO:0003824,GO:0006629,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0044237,GO:0044238,GO:0044255,GO:0071704 ko:K07019 ko00000 Bacteria 1MWV1@1224,2TSMR@28211,COG0429@1,COG0429@2 NA|NA|NA S alpha/beta hydrolase fold MAG.T12.14_00567 66377.JOBH01000004_gene3779 6.5e-48 198.0 Actinobacteria Bacteria 2A4ZY@1,2GMC5@201174,30TN1@2 NA|NA|NA MAG.T12.14_00568 743721.Psesu_0725 9.4e-157 559.7 Xanthomonadales gapA GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0042866,GO:0043436,GO:0043891,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 iAPECO1_1312.APECO1_847,iPC815.YPO2157,iUTI89_1310.UTI89_C1975,ic_1306.c2184 Bacteria 1MU93@1224,1RMBM@1236,1X34S@135614,COG0057@1,COG0057@2 NA|NA|NA G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family MAG.T12.14_00569 1449353.JQMQ01000005_gene485 2.6e-11 74.7 Actinobacteria Bacteria 2BNAP@1,2GTB3@201174,32GYA@2 NA|NA|NA MAG.T12.14_00570 1048339.KB913029_gene3575 1.9e-95 355.5 Actinobacteria thyX 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 R06613 RC00022,RC00332 ko00000,ko00001,ko01000 Bacteria 2HCNJ@201174,COG1351@1,COG1351@2 NA|NA|NA F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant MAG.T12.14_00571 1193181.BN10_1320023 7.5e-57 227.3 Actinobacteria 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 R00578 RC00010 ko00000,ko00001,ko01000,ko01002 Bacteria 2IAKK@201174,COG1478@1,COG1478@2 NA|NA|NA S F420-0:Gamma-glutamyl ligase MAG.T12.14_00572 68570.DC74_5827 1.2e-107 396.4 Actinobacteria dapA 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ34@201174,COG0329@1,COG0329@2 NA|NA|NA E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) MAG.T12.14_00573 1095767.CAHD01000224_gene2103 2.8e-238 831.2 Cellulomonadaceae rnj GO:0003674,GO:0005488,GO:0005515,GO:0042802 ko:K12574 ko03018,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 2GIW7@201174,4F0MZ@85016,COG0595@1,COG0595@2 NA|NA|NA S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay MAG.T12.14_00574 351607.Acel_1501 2.6e-252 878.6 Frankiales ftsK GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 ko:K03466 ko00000,ko03036 3.A.12 Bacteria 2GK3T@201174,4ERQD@85013,COG1674@1,COG1674@2 NA|NA|NA D DNA translocase ftsK MAG.T12.14_00575 1120950.KB892756_gene6657 4.5e-155 554.7 Propionibacteriales rimO GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016782,GO:0018193,GO:0018197,GO:0018198,GO:0018339,GO:0019538,GO:0035596,GO:0035599,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901564 2.8.4.4 ko:K14441 R10652 RC00003,RC03217 ko00000,ko01000,ko03009 Bacteria 2GKRI@201174,4DNHY@85009,COG0621@1,COG0621@2 NA|NA|NA J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 MAG.T12.14_00576 471852.Tcur_3305 9e-52 210.3 Streptosporangiales pgsA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 Bacteria 2GK5D@201174,4EIN9@85012,COG0558@1,COG0558@2 NA|NA|NA I CDP-alcohol phosphatidyltransferase MAG.T12.14_00577 1122239.AULS01000007_gene453 4.3e-25 121.3 Microbacteriaceae cinA 3.5.1.42 ko:K03742,ko:K03743 ko00760,map00760 R02322 RC00100 ko00000,ko00001,ko01000 Bacteria 2IQ8T@201174,4FPN9@85023,COG1546@1,COG1546@2 NA|NA|NA S Competence-damaged protein MAG.T12.14_00578 1476876.JOJO01000017_gene1354 2.8e-23 114.4 Actinobacteria clgR GO:0002682,GO:0002683,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006109,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009268,GO:0009408,GO:0009605,GO:0009607,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009894,GO:0009987,GO:0010447,GO:0010468,GO:0010556,GO:0010557,GO:0010565,GO:0010604,GO:0010628,GO:0010675,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0022611,GO:0030162,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031347,GO:0031348,GO:0032268,GO:0032502,GO:0033554,GO:0035821,GO:0040007,GO:0042176,GO:0043207,GO:0043565,GO:0043620,GO:0044003,GO:0044110,GO:0044111,GO:0044114,GO:0044115,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044413,GO:0044414,GO:0044419,GO:0045088,GO:0045824,GO:0045893,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048583,GO:0048585,GO:0050776,GO:0050777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051252,GO:0051254,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051817,GO:0051832,GO:0051833,GO:0052031,GO:0052037,GO:0052167,GO:0052170,GO:0052173,GO:0052200,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0060255,GO:0061136,GO:0062012,GO:0065007,GO:0075136,GO:0080090,GO:0080134,GO:0085016,GO:0090062,GO:0097159,GO:1901363,GO:1902680,GO:1902882,GO:1903050,GO:1903362,GO:1903506,GO:1903508,GO:2000112,GO:2001141 Bacteria 2GR3F@201174,COG1396@1,COG1396@2 NA|NA|NA K transcriptional MAG.T12.14_00579 1054860.KB913030_gene4976 0.0 1554.3 Actinobacteria lhr GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 ko:K03724 ko00000,ko01000,ko03400 Bacteria 2GJG3@201174,COG1201@1,COG1201@2 NA|NA|NA L dead DEAH box helicase MAG.T12.14_00580 1380354.JIAN01000007_gene107 1.7e-161 575.5 Cellulomonadaceae recA GO:0000150,GO:0000166,GO:0000287,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009650,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0031668,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042148,GO:0042221,GO:0042623,GO:0043142,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 ko:K03553 ko03440,map03440 M00729 ko00000,ko00001,ko00002,ko03400 Bacteria 2GJ4P@201174,4F0Z7@85016,COG0468@1,COG0468@2 NA|NA|NA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage MAG.T12.14_00581 1121272.KB903272_gene431 2.1e-33 149.1 Micromonosporales recX GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03565 ko00000,ko03400 Bacteria 2GMRF@201174,4DD5X@85008,COG2137@1,COG2137@2 NA|NA|NA S Modulates RecA activity MAG.T12.14_00582 471852.Tcur_3285 1.5e-195 689.1 Streptosporangiales miaB 2.8.4.3 ko:K06168 R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 Bacteria 2GJEV@201174,4EFYX@85012,COG0621@1,COG0621@2 NA|NA|NA J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine MAG.T12.14_00583 66377.JOBH01000011_gene2229 2.8e-22 112.5 Actinobacteria 2.8.4.3 ko:K06168 R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 Bacteria 2GN3T@201174,COG3885@1,COG3885@2 NA|NA|NA S ferrous iron binding MAG.T12.14_00584 266940.Krad_1500 2e-76 292.7 Actinobacteria miaA GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006417,GO:0006725,GO:0006807,GO:0006950,GO:0008033,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009451,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016070,GO:0016740,GO:0016765,GO:0019222,GO:0031323,GO:0031326,GO:0032268,GO:0033554,GO:0034248,GO:0034470,GO:0034605,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0043555,GO:0044237,GO:0044238,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0051716,GO:0052381,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1990497,GO:2000112,GO:2000765 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 Bacteria 2GKFT@201174,COG0324@1,COG0324@2 NA|NA|NA J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) MAG.T12.14_00585 1449346.JQMO01000003_gene3598 1.6e-72 279.6 Kitasatospora dapF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 iIT341.HP0566,iLJ478.TM1522 Bacteria 2GKUD@201174,2M07M@2063,COG0253@1,COG0253@2 NA|NA|NA E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan MAG.T12.14_00586 1048339.KB913029_gene4763 4.8e-172 610.9 Frankiales hflX GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 ko:K03665 ko00000,ko03009 Bacteria 2GK55@201174,4ERJ5@85013,COG2262@1,COG2262@2 NA|NA|NA S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis MAG.T12.14_00587 471857.Svir_29270 3.4e-163 582.0 Pseudonocardiales dinG GO:0003674,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008026,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0042575,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0045004,GO:0045005,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7,3.6.4.12 ko:K02342,ko:K03722 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 2GKT8@201174,4E0JP@85010,COG1199@1,COG1199@2 NA|NA|NA KL helicase MAG.T12.14_00588 1169154.KB897780_gene2333 6e-122 444.5 Actinobacteria Bacteria 2GKEK@201174,COG4320@1,COG4320@2 NA|NA|NA K protein conserved in bacteria MAG.T12.14_00589 1120950.KB892707_gene4592 5.9e-83 313.9 Propionibacteriales lexA GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0033554,GO:0042221,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045934,GO:0046677,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 3.4.21.88 ko:K01356 M00729 ko00000,ko00002,ko01000,ko01002,ko03400 Bacteria 2GMBN@201174,4DNCQ@85009,COG1974@1,COG1974@2 NA|NA|NA K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair MAG.T12.14_00590 1150399.AQYK01000002_gene2473 2.6e-11 75.1 Microbacteriaceae Bacteria 2GWI9@201174,4FQ73@85023,COG1388@1,COG1388@2 NA|NA|NA M Lysin motif MAG.T12.14_00591 469371.Tbis_2426 5.1e-55 220.7 Pseudonocardiales nrdR GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 ko:K07738 ko00000,ko03000 Bacteria 2IHU9@201174,4E2M8@85010,COG1327@1,COG1327@2 NA|NA|NA K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes MAG.T12.14_00592 1120934.KB894440_gene5692 0.0 1456.4 Pseudonocardiales nrdJ 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 Bacteria 2GKX9@201174,4DY0W@85010,COG0209@1,COG0209@2 NA|NA|NA F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen MAG.T12.14_00593 1122939.ATUD01000001_gene368 1.4e-74 287.0 Actinobacteria Bacteria 2IKC2@201174,COG3437@1,COG3437@2 NA|NA|NA T cheY-homologous receiver domain MAG.T12.14_00594 1049564.TevJSym_af00930 6.4e-80 304.7 unclassified Gammaproteobacteria phcR ko:K19622 ko02020,map02020 ko00000,ko00001,ko02022 Bacteria 1J6BK@118884,1RCW6@1224,1S3XV@1236,COG1639@1,COG1639@2,COG2204@1,COG2204@2 NA|NA|NA T HDOD domain MAG.T12.14_00595 1121459.AQXE01000005_gene1544 4.8e-105 388.7 Desulfovibrionales Bacteria 1RCM9@1224,2MHHP@213115,2WKHK@28221,42PGC@68525,COG4191@1,COG4191@2 NA|NA|NA T Histidine kinase-like ATPases MAG.T12.14_00597 595494.Tola_0290 2.2e-60 238.4 Gammaproteobacteria rpiB 5.3.1.6 ko:K01808 ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1604 Bacteria 1RHBF@1224,1SAUU@1236,COG0698@1,COG0698@2 NA|NA|NA G Ribose 5-phosphate isomerase MAG.T12.14_00598 1112204.GPOL_c02910 2.3e-40 171.8 Gordoniaceae yccF Bacteria 2IKS5@201174,4GE90@85026,COG3304@1,COG3304@2 NA|NA|NA S Inner membrane component domain MAG.T12.14_00599 398580.Dshi_3076 2.2e-09 68.9 Alphaproteobacteria greA GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006354,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0030312,GO:0031323,GO:0031326,GO:0032774,GO:0032784,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 ko:K03624 ko00000,ko03021 Bacteria 1RCXW@1224,2U5JU@28211,COG0782@1,COG0782@2 NA|NA|NA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides MAG.T12.14_00600 1211815.CBYP010000071_gene1316 8.6e-23 114.8 Frankiales Bacteria 2AR9G@1,2GN9V@201174,31GJC@2,4EWX7@85013 NA|NA|NA S Domain of unknown function (DUF4192) MAG.T12.14_00601 1306174.JODP01000013_gene7801 4.4e-215 753.8 Actinobacteria metY 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 iNJ661.Rv3340 Bacteria 2I2EB@201174,COG2873@1,COG2873@2 NA|NA|NA E O-acetylhomoserine MAG.T12.14_00602 196162.Noca_2967 1.6e-27 129.0 Propionibacteriales Bacteria 2IR3G@201174,4DRRV@85009,COG0589@1,COG0589@2 NA|NA|NA T Universal stress protein family MAG.T12.14_00604 420662.Mpe_A3085 7.7e-23 112.8 unclassified Burkholderiales dbi 1.1.1.35 ko:K07516 ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212 M00087 R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000 Bacteria 1KM9E@119065,1MZPP@1224,2VUK0@28216,COG4281@1,COG4281@2 NA|NA|NA I acyl-coA-binding protein MAG.T12.14_00605 1121926.AXWO01000013_gene2101 9e-55 220.7 Glycomycetales ytnM ko:K07090 ko00000 Bacteria 2GNPE@201174,4EZI4@85014,COG0730@1,COG0730@2 NA|NA|NA S Sulfite exporter TauE/SafE MAG.T12.14_00606 1869.MB27_19770 2.2e-87 328.9 Micromonosporales ppgK 2.7.1.2,2.7.1.63,5.3.1.9 ko:K00845,ko:K00886,ko:K01810 ko00010,ko00030,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114,M00549 R00299,R01600,R01786,R02187,R02189,R02739,R02740,R03321 RC00002,RC00017,RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GJA0@201174,4DCFF@85008,COG1940@1,COG1940@2 NA|NA|NA GK ROK family MAG.T12.14_00607 1298863.AUEP01000005_gene2350 8.5e-21 106.7 Propionibacteriales Bacteria 2CEFP@1,2GT06@201174,2ZGIZ@2,4DVNV@85009 NA|NA|NA MAG.T12.14_00608 1172188.KB911825_gene3704 2.3e-72 279.6 Intrasporangiaceae Bacteria 2IAG1@201174,4FEJ3@85021,COG4585@1,COG4585@2 NA|NA|NA T Histidine kinase MAG.T12.14_00609 196162.Noca_2635 8.9e-57 226.9 Propionibacteriales Bacteria 2GJKM@201174,4DQZM@85009,COG2197@1,COG2197@2 NA|NA|NA T helix_turn_helix, Lux Regulon MAG.T12.14_00610 1894.JOER01000006_gene836 1.5e-10 73.2 Actinobacteria 3.1.3.12 ko:K01087 ko00500,ko01100,map00500,map01100 R02778 RC00017 ko00000,ko00001,ko01000 Bacteria 2IKKW@201174,COG1877@1,COG1877@2 NA|NA|NA G trehalose-phosphatase activity MAG.T12.14_00611 366602.Caul_2877 1.3e-64 253.4 Alphaproteobacteria yceM 1.1.1.18,1.1.1.369 ko:K00010,ko:K03810 ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130 R01183,R09951 RC00182 ko00000,ko00001,ko01000 Bacteria 1MVCX@1224,2UQ6G@28211,COG0673@1,COG0673@2 NA|NA|NA S Oxidoreductase family, NAD-binding Rossmann fold MAG.T12.14_00612 1206725.BAFU01000044_gene2179 2.7e-56 226.5 Nocardiaceae 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 2HEI2@201174,4FV0Z@85025,COG2199@1,COG2199@2,COG5000@1,COG5000@2 NA|NA|NA T diguanylate cyclase MAG.T12.14_00613 66377.JOBH01000008_gene6677 1.7e-38 166.0 Actinobacteria pfs 3.2.2.1,3.2.2.9 ko:K01239,ko:K01243 ko00230,ko00270,ko00760,ko01100,ko01230,map00230,map00270,map00760,map01100,map01230 M00034,M00609 R00194,R01245,R01273,R01401,R01677,R01770,R02143 RC00033,RC00063,RC00122,RC00318,RC00485 ko00000,ko00001,ko00002,ko01000 Bacteria 2IMZ7@201174,COG0775@1,COG0775@2 NA|NA|NA F nucleosidase MAG.T12.14_00614 394.NGR_c28520 2.8e-182 644.8 Rhizobiaceae arcA 3.5.3.6 ko:K01478 ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130 R00552 RC00177 ko00000,ko00001,ko01000 Bacteria 1NCGV@1224,2TU0Z@28211,4BAQ4@82115,COG2235@1,COG2235@2 NA|NA|NA E Arginine MAG.T12.14_00615 762948.HMPREF0733_10179 1.1e-13 82.4 Micrococcaceae Bacteria 1WAB6@1268,2IQY7@201174,COG2261@1,COG2261@2 NA|NA|NA S Transglycosylase associated protein MAG.T12.14_00617 1150864.MILUP08_45615 1.6e-47 196.4 Micromonosporales 4.2.1.18 ko:K13766 ko00280,ko01100,map00280,map01100 M00036 R02085 RC02416 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ0N@201174,4D9QW@85008,COG1024@1,COG1024@2 NA|NA|NA I enoyl-CoA hydratase MAG.T12.14_00618 2002.JOEQ01000005_gene3278 5.6e-30 137.9 Streptosporangiales Bacteria 2GP59@201174,4EQ00@85012,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family MAG.T12.14_00620 1238182.C882_4443 1.9e-81 310.1 Rhodospirillales ko:K06990,ko:K09141 ko00000,ko04812 Bacteria 1MXK5@1224,2JQVM@204441,2U13I@28211,COG1355@1,COG1355@2,COG2078@1,COG2078@2 NA|NA|NA S Belongs to the MEMO1 family MAG.T12.14_00621 1415778.JQMM01000001_gene264 4.5e-152 544.3 unclassified Gammaproteobacteria pflA 1.97.1.4 ko:K04069 R04710 ko00000,ko01000 Bacteria 1J9SI@118884,1NQC1@1224,1TH6D@1236,COG1180@1,COG1180@2 NA|NA|NA O Radical SAM superfamily MAG.T12.14_00622 1120948.KB903247_gene4611 2.8e-147 529.3 Pseudonocardiales 6.4.1.3,6.4.1.4 ko:K01965,ko:K01968 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00036,M00373,M00741 R01859,R04138 RC00097,RC00367,RC00609,RC00942 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIZP@201174,4DZTM@85010,COG4770@1,COG4770@2 NA|NA|NA I Acetyl propionyl-CoA carboxylase, alpha subunit MAG.T12.14_00623 479433.Caci_0163 1.1e-183 649.8 Actinobacteria atuC 2.1.3.15,6.4.1.2,6.4.1.3,6.4.1.4,6.4.1.5 ko:K01966,ko:K01969,ko:K13778,ko:K18472 ko00061,ko00280,ko00281,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00281,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212 M00036,M00082,M00373,M00741 R00742,R01859,R03494,R04138,R04386 RC00040,RC00097,RC00253,RC00367,RC00609,RC00942 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIRU@201174,COG4799@1,COG4799@2 NA|NA|NA I Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta MAG.T12.14_00625 479431.Namu_4967 3.2e-83 315.5 Frankiales kch 3.6.1.22 ko:K03426,ko:K10716 ko00760,ko01100,ko04146,map00760,map01100,map04146 R00103,R03004,R11104 RC00002 ko00000,ko00001,ko01000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 Bacteria 2GKB8@201174,4ERFU@85013,COG1226@1,COG1226@2 NA|NA|NA P Ion channel MAG.T12.14_00626 1313172.YM304_23820 2.3e-39 168.7 Actinobacteria ko:K07117 ko00000 Bacteria 2GQAV@201174,COG2940@1,COG2940@2 NA|NA|NA K SET domain MAG.T12.14_00627 1380347.JNII01000012_gene2677 6.2e-54 217.2 Frankiales bpa GO:0000502,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010604,GO:0016020,GO:0016043,GO:0019222,GO:0022607,GO:0022624,GO:0030162,GO:0030312,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0032268,GO:0032270,GO:0032991,GO:0042176,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0044877,GO:0045732,GO:0045862,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051259,GO:0051260,GO:0060255,GO:0061136,GO:0065003,GO:0065007,GO:0070628,GO:0071840,GO:0071944,GO:0080090,GO:1901800,GO:1902494,GO:1903050,GO:1903052,GO:1903362,GO:1903364,GO:1905368,GO:1905369 Bacteria 291ZT@1,2GR7R@201174,2ZPJ4@2,4ESN9@85013 NA|NA|NA S Protein of unknown function (DUF2587) MAG.T12.14_00628 253839.SSNG_03609 1e-171 609.8 Actinobacteria serS GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 2GIWP@201174,COG0172@1,COG0172@2 NA|NA|NA J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) MAG.T12.14_00629 266940.Krad_0255 1.3e-41 177.2 Actinobacteria Bacteria 2GP42@201174,COG0561@1,COG0561@2 NA|NA|NA J hydrolase MAG.T12.14_00630 172088.AUGA01000001_gene6522 8.4e-103 380.2 Bradyrhizobiaceae pheA GO:0003674,GO:0003824,GO:0004106,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 2.5.1.54,4.2.1.51,5.4.99.5 ko:K03856,ko:K04518,ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022,M00024,M00025 R00691,R01373,R01715,R01826 RC00360,RC00435,RC03116 ko00000,ko00001,ko00002,ko01000 iECNA114_1301.ECNA114_2667 Bacteria 1MU60@1224,2TSUT@28211,3JS53@41294,COG0077@1,COG0077@2 NA|NA|NA E Prephenate dehydratase MAG.T12.14_00631 436229.JOEH01000009_gene4397 7.6e-81 307.4 Streptacidiphilus glpQ 3.1.4.46 ko:K01126 ko00564,map00564 R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 Bacteria 2GMMS@201174,2NI2R@228398,COG0584@1,COG0584@2 NA|NA|NA C Glycerophosphoryl diester phosphodiesterase family MAG.T12.14_00632 1121928.AUHE01000001_gene1507 2.9e-76 292.7 Gordoniaceae glcD2 GO:0000166,GO:0003674,GO:0003824,GO:0004457,GO:0004458,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006089,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016053,GO:0016491,GO:0016614,GO:0016898,GO:0019249,GO:0019516,GO:0019752,GO:0022900,GO:0022904,GO:0030447,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046394,GO:0048037,GO:0050660,GO:0050662,GO:0051990,GO:0055114,GO:0071704,GO:0071949,GO:0072330,GO:0097159,GO:0099615,GO:1901265,GO:1901363,GO:1901576,GO:1901615,GO:1901617 1.1.2.4 ko:K00102 ko00620,map00620 R00197 RC00044 ko00000,ko00001,ko01000 Bacteria 2GKI9@201174,4GB5H@85026,COG0277@1,COG0277@2 NA|NA|NA C FAD linked oxidases, C-terminal domain MAG.T12.14_00633 446462.Amir_6917 2.9e-129 468.4 Pseudonocardiales fbaA GO:0003674,GO:0003824,GO:0004332,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016830,GO:0016832,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035375,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 iZ_1308.Z4263 Bacteria 2GM5P@201174,4DZK9@85010,COG0191@1,COG0191@2 NA|NA|NA G fructose-bisphosphate aldolase, class II, yeast E. coli subtype MAG.T12.14_00634 1081644.IMCC13023_01920 2.3e-192 678.3 Microbacteriaceae purA GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 Bacteria 2GMP4@201174,4FKSZ@85023,COG0104@1,COG0104@2 NA|NA|NA F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP MAG.T12.14_00635 1499680.CCFE01000011_gene564 1.9e-69 270.0 Firmicutes Bacteria 1V0SJ@1239,COG5434@1,COG5434@2 NA|NA|NA M Parallel beta-helix repeats MAG.T12.14_00636 287986.DV20_41565 4.8e-72 277.7 Pseudonocardiales namA 1.6.99.1 ko:K00354 R00282 RC00001 ko00000,ko01000 Bacteria 2GK8E@201174,4DZZE@85010,COG1902@1,COG1902@2 NA|NA|NA C PFAM NADH flavin oxidoreductase NADH oxidase MAG.T12.14_00637 1089547.KB913013_gene3117 1.9e-42 178.7 Cytophagia namA 1.6.99.1 ko:K00354 R00282 RC00001 ko00000,ko01000 Bacteria 47JFR@768503,4NF98@976,COG1902@1,COG1902@2 NA|NA|NA C NADH flavin oxidoreductase NADH oxidase MAG.T12.14_00638 935866.JAER01000008_gene934 2e-178 632.1 Propionibacteriales 2.6.1.55 ko:K15372 ko00410,ko00430,ko01100,map00410,map00430,map01100 R00908,R01684 RC00006,RC00062 ko00000,ko00001,ko01000 Bacteria 2I2F3@201174,4DP1H@85009,COG0160@1,COG0160@2 NA|NA|NA E Aminotransferase class-III MAG.T12.14_00639 1048339.KB913029_gene1446 4.6e-153 547.7 Frankiales purD GO:0000166,GO:0003674,GO:0003824,GO:0004637,GO:0005488,GO:0005524,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.2.6,6.3.3.1,6.3.4.13,6.3.5.3 ko:K01945,ko:K01952,ko:K11788,ko:K13713 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144,R04208,R04463,R04591 RC00010,RC00064,RC00090,RC00162,RC00166,RC01100,RC01160 ko00000,ko00001,ko00002,ko01000 iECNA114_1301.ECNA114_3417,iECSF_1327.ECSF_3859,iJN746.PP_4823,iPC815.YPO3729,iSB619.SA_RS05245,iYO844.BSU06530 Bacteria 2I2F5@201174,4ERHW@85013,COG0151@1,COG0151@2 NA|NA|NA F Belongs to the GARS family MAG.T12.14_00640 105425.BBPL01000013_gene1809 4e-198 697.6 Streptacidiphilus purB 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKBR@201174,2NGEH@228398,COG0015@1,COG0015@2 NA|NA|NA F Adenylosuccinate lyase C-terminus MAG.T12.14_00641 196162.Noca_4337 1.5e-113 416.0 Propionibacteriales purC GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6,6.3.4.13 ko:K01923,ko:K01945,ko:K03566 ko00230,ko01100,ko01110,ko01130,ko02026,map00230,map01100,map01110,map01130,map02026 M00048 R04144,R04591 RC00064,RC00090,RC00162,RC00166 ko00000,ko00001,ko00002,ko01000,ko03000 Bacteria 2GK3H@201174,4DP92@85009,COG0152@1,COG0152@2 NA|NA|NA F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL MAG.T12.14_00642 1193181.BN10_880002 1.3e-207 729.2 Intrasporangiaceae pntB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008746,GO:0008750,GO:0009117,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016652,GO:0019362,GO:0019637,GO:0031224,GO:0031226,GO:0034641,GO:0036094,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050661,GO:0050662,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072524,GO:0097159,GO:1901265,GO:1901360,GO:1901363,GO:1901564 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 R00112 RC00001 ko00000,ko00001,ko01000 iSBO_1134.SBO_1534,iYL1228.KPN_01527 Bacteria 2GNKB@201174,4FECY@85021,COG1282@1,COG1282@2 NA|NA|NA C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane MAG.T12.14_00643 1193181.BN10_880001 2.2e-213 748.4 Intrasporangiaceae pntA GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008746,GO:0008750,GO:0009117,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016652,GO:0019362,GO:0019637,GO:0031224,GO:0031226,GO:0034641,GO:0036094,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0046483,GO:0046496,GO:0046983,GO:0048037,GO:0050661,GO:0050662,GO:0051186,GO:0051287,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072524,GO:0097159,GO:1901265,GO:1901360,GO:1901363,GO:1901564 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 R00112 RC00001 ko00000,ko00001,ko01000 iEcE24377_1341.EcE24377A_1810 Bacteria 2I2FZ@201174,4FEB2@85021,COG3288@1,COG3288@2 NA|NA|NA C NAD(P) transhydrogenase subunit alpha MAG.T12.14_00644 570268.ANBB01000035_gene2253 2.3e-168 599.0 Streptosporangiales ptsI 2.7.3.9 ko:K08483 ko02060,map02060 ko00000,ko00001,ko01000,ko02000 8.A.7 Bacteria 2GIZZ@201174,4EGVU@85012,COG1080@1,COG1080@2 NA|NA|NA G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) MAG.T12.14_00645 1292373.H640_07474 2.5e-16 91.3 Actinobacteria ptsH ko:K03488,ko:K11189 ko00000,ko02000,ko03000 4.A.2.1 Bacteria 2GQX6@201174,COG1925@1,COG1925@2 NA|NA|NA G phosphocarrier protein hpr MAG.T12.14_00646 44060.JODL01000022_gene5029 2.9e-33 148.3 Actinobacteria crr 2.7.1.193,2.7.1.199 ko:K02777,ko:K02802,ko:K20116,ko:K20117,ko:K20118 ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111 M00265,M00266,M00267,M00268,M00270,M00272,M00303,M00806,M00809 R02738,R02780,R04111,R04394,R05132,R05199,R08559 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.1,4.A.1.1.13,4.A.1.1.14,4.A.1.1.2,4.A.1.1.9 Bacteria 2GK6B@201174,COG2190@1,COG2190@2 NA|NA|NA G Pts system MAG.T12.14_00647 471852.Tcur_4029 6.1e-19 99.8 Streptosporangiales 2.7.1.193 ko:K02803 ko00520,ko02060,map00520,map02060 M00267 R05199 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7 Bacteria 2IQIB@201174,4EKNU@85012,COG1264@1,COG1264@2 NA|NA|NA G phosphotransferase system, EIIB MAG.T12.14_00648 1449058.JQKT01000009_gene122 1.5e-75 290.0 Bacteria 5.5.1.24 ko:K09834 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00112 R07502,R07503,R10623,R10624 RC01911 ko00000,ko00001,ko00002,ko01000 Bacteria 2Z7HP@2,arCOG12964@1 NA|NA|NA S Tocopherol cyclase MAG.T12.14_00649 351607.Acel_2022 1.9e-103 382.9 Frankiales pntAA 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 R00112 RC00001 ko00000,ko00001,ko01000 Bacteria 2I2FZ@201174,4ERQN@85013,COG3288@1,COG3288@2 NA|NA|NA C PFAM alanine dehydrogenase PNT domain protein MAG.T12.14_00650 1120960.ATXG01000003_gene2102 3.4e-25 120.9 Microbacteriaceae pntAB 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 R00112 RC00001 ko00000,ko00001,ko01000 Bacteria 2IKR9@201174,4FPHA@85023,COG3288@1,COG3288@2 NA|NA|NA C 4TM region of pyridine nucleotide transhydrogenase, mitoch MAG.T12.14_00651 479433.Caci_8567 5.8e-141 507.7 Actinobacteria pntB 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 R00112 RC00001 ko00000,ko00001,ko01000 Bacteria 2GNKB@201174,COG1282@1,COG1282@2 NA|NA|NA C the transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane MAG.T12.14_00652 2045.KR76_24730 5e-51 207.2 Propionibacteriales tadA 3.5.4.1,3.5.4.33,3.8.1.5,6.3.4.19 ko:K01485,ko:K01563,ko:K04075,ko:K11991 ko00240,ko00330,ko00361,ko00625,ko01100,ko01120,map00240,map00330,map00361,map00625,map01100,map01120 R00974,R01411,R02922,R05284,R05367,R05368,R05369,R05370,R07669,R07670,R09597,R10223 RC00074,RC00477,RC00514,RC00809,RC01317,RC01340,RC01341,RC02013,RC02633,RC02634 ko00000,ko00001,ko01000,ko03016 Bacteria 2IM3Z@201174,4DQP2@85009,COG0590@1,COG0590@2 NA|NA|NA FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) MAG.T12.14_00653 266940.Krad_0471 1.7e-71 275.8 Actinobacteria upp GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.9 ko:K00761 ko00240,ko01100,map00240,map01100 R00966 RC00063 ko00000,ko00001,ko01000 Bacteria 2GPJE@201174,COG0035@1,COG0035@2 NA|NA|NA F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate MAG.T12.14_00654 1192034.CAP_7082 4e-43 182.2 Myxococcales ykfA 3.4.17.13 ko:K01297 ko00000,ko01000,ko01002,ko01011 Bacteria 1MWIY@1224,2WJ3S@28221,2YV3I@29,42Q52@68525,COG1619@1,COG1619@2 NA|NA|NA V LD-carboxypeptidase MAG.T12.14_00656 1896.JOAU01000009_gene6381 7.3e-47 193.4 Actinobacteria osmC ko:K04063 ko00000 Bacteria 2IFFB@201174,COG1764@1,COG1764@2 NA|NA|NA O PFAM OsmC family protein MAG.T12.14_00657 436229.JOEH01000017_gene6930 0.0 1198.7 Streptacidiphilus clpB GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 ko:K03694,ko:K03695 ko04213,map04213 ko00000,ko00001,ko03110 Bacteria 2GJ73@201174,2NGRH@228398,COG0542@1,COG0542@2 NA|NA|NA O C-terminal, D2-small domain, of ClpB protein MAG.T12.14_00658 31964.CMS2809 6.6e-27 126.7 Microbacteriaceae hspR ko:K13640 ko00000,ko03000 Bacteria 2IQJ4@201174,4FP4F@85023,COG0789@1,COG0789@2 NA|NA|NA K helix_turn_helix, mercury resistance MAG.T12.14_00659 1122611.KB903952_gene6087 6.6e-109 401.0 Streptosporangiales dnaJ GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0010468,GO:0016020,GO:0019222,GO:0030312,GO:0040007,GO:0043388,GO:0044093,GO:0044464,GO:0050789,GO:0051098,GO:0051099,GO:0051101,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:2000677,GO:2000679 ko:K03686,ko:K05516 ko00000,ko03029,ko03036,ko03110 Bacteria 2GJKK@201174,4EHSG@85012,COG0484@1,COG0484@2 NA|NA|NA O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins MAG.T12.14_00660 351607.Acel_2116 9.4e-41 173.7 Frankiales grpE GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0007154,GO:0008150,GO:0009266,GO:0009267,GO:0009408,GO:0009605,GO:0009628,GO:0009986,GO:0009987,GO:0009991,GO:0016043,GO:0017076,GO:0019904,GO:0022607,GO:0030234,GO:0030246,GO:0030247,GO:0030312,GO:0030554,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0033554,GO:0036094,GO:0040007,GO:0042594,GO:0042802,GO:0042803,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0050790,GO:0050896,GO:0051082,GO:0051716,GO:0060589,GO:0060590,GO:0065003,GO:0065007,GO:0065009,GO:0071496,GO:0071840,GO:0071944,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065 ko:K02652,ko:K03687 ko00000,ko02035,ko02044,ko03029,ko03110 3.A.15.2 Bacteria 2GP4F@201174,4ESWP@85013,COG0576@1,COG0576@2 NA|NA|NA O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ MAG.T12.14_00661 479431.Namu_5218 8.1e-123 446.8 Frankiales dnaK GO:0000302,GO:0000303,GO:0000305,GO:0001968,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016020,GO:0016310,GO:0019222,GO:0019538,GO:0019899,GO:0030112,GO:0030162,GO:0030312,GO:0030313,GO:0031323,GO:0031325,GO:0031975,GO:0031982,GO:0032268,GO:0032270,GO:0033554,GO:0034599,GO:0034614,GO:0035375,GO:0036211,GO:0040007,GO:0042221,GO:0042603,GO:0043170,GO:0043226,GO:0043227,GO:0043230,GO:0043388,GO:0043412,GO:0044044,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046677,GO:0046688,GO:0046777,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051098,GO:0051099,GO:0051101,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0070613,GO:0070887,GO:0071450,GO:0071451,GO:0071704,GO:0071944,GO:0080090,GO:0097691,GO:1901564,GO:1901700,GO:1901701,GO:1903317,GO:1903319,GO:1903561,GO:2000677,GO:2000679 ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 Bacteria 2GJTY@201174,4ERTY@85013,COG0443@1,COG0443@2 NA|NA|NA O Heat shock 70 kDa protein MAG.T12.14_00662 1095767.CAHD01000239_gene1882 5.7e-59 234.6 Actinobacteria ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 28JAE@1,2IFSW@201174,2Z957@2 NA|NA|NA MAG.T12.14_00664 591167.Sfla_5812 9.3e-37 160.2 Actinobacteria 3.6.1.13 ko:K01515 ko00230,map00230 R01054 RC00002 ko00000,ko00001,ko01000 Bacteria 2GRXY@201174,COG0494@1,COG0494@2 NA|NA|NA L NUDIX domain MAG.T12.14_00665 1366050.N234_19840 1.8e-38 165.6 Burkholderiaceae ypeA ko:K03826 ko00000,ko01000 Bacteria 1K7QV@119060,1RA6D@1224,2VSN2@28216,COG0454@1,COG0456@2 NA|NA|NA K PFAM GCN5-related N-acetyltransferase MAG.T12.14_00666 110319.CF8_3936 8.8e-280 969.5 Propionibacteriales 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 Bacteria 2GIRF@201174,4DN8M@85009,COG2217@1,COG2217@2 NA|NA|NA P Heavy-metal-associated domain MAG.T12.14_00667 1348338.ADILRU_1018 4e-31 140.6 Microbacteriaceae ko:K21600 ko00000,ko03000 Bacteria 2IQAC@201174,4FPHS@85023,COG1937@1,COG1937@2 NA|NA|NA S Metal-sensitive transcriptional repressor MAG.T12.14_00668 66897.DJ64_20775 3.5e-116 424.9 Actinobacteria 3.2.1.23,3.2.1.97 ko:K01190,ko:K17624 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 GH101 Bacteria 2I952@201174,COG3250@1,COG3250@2 NA|NA|NA G Protein of unknown function (DUF2804) MAG.T12.14_00669 222534.KB893694_gene64 1.2e-30 140.2 Frankiales Bacteria 2I8Y7@201174,4EWZT@85013,COG2197@1,COG2197@2 NA|NA|NA T Response regulator receiver MAG.T12.14_00670 2045.KR76_02335 1.5e-18 101.7 Propionibacteriales Bacteria 2HQ5S@201174,4DS25@85009,COG4585@1,COG4585@2 NA|NA|NA T Histidine kinase-like ATPases MAG.T12.14_00671 235985.BBPN01000007_gene3291 6.7e-187 660.6 Streptacidiphilus ycfI ko:K06147 ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 2GITR@201174,2NEN1@228398,COG1132@1,COG1132@2 NA|NA|NA V ABC transporter transmembrane region MAG.T12.14_00675 1054860.KB913030_gene1900 8e-44 183.0 Actinobacteria ko:K06147 ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 2GITR@201174,COG1132@1,COG1132@2 NA|NA|NA V ABC transporter MAG.T12.14_00676 1445613.JALM01000036_gene2693 1.6e-11 75.5 Pseudonocardiales Bacteria 2DGB7@1,2GV3X@201174,2ZV98@2,4E6RY@85010 NA|NA|NA MAG.T12.14_00677 590998.Celf_3653 8.9e-51 208.4 Actinobacteria Bacteria 2GIZF@201174,COG2202@1,COG2202@2,COG5001@1,COG5001@2,COG5002@1,COG5002@2 NA|NA|NA T signal transduction protein containing a membrane domain an EAL and a GGDEF domain MAG.T12.14_00678 1283283.ATXA01000007_gene3910 1.7e-120 440.3 Frankiales Bacteria 2GIZF@201174,4ERVM@85013,COG5001@1,COG5001@2 NA|NA|NA T Diguanylate cyclase MAG.T12.14_00679 479431.Namu_4836 1.5e-104 386.3 Frankiales alx ko:K05794 ko00000 Bacteria 2GIWU@201174,4ERNE@85013,COG0861@1,COG0861@2 NA|NA|NA P membrane protein, TerC MAG.T12.14_00680 479431.Namu_1913 1.2e-114 419.9 Actinobacteria egsA 1.1.1.261 ko:K00096 ko00564,map00564 R05679,R05680 RC00029 ko00000,ko00001,ko01000 Bacteria 2GKWA@201174,COG0371@1,COG0371@2 NA|NA|NA C Dehydrogenase MAG.T12.14_00681 479431.Namu_1914 9.4e-104 383.3 Frankiales nagD ko:K02566 ko00000 Bacteria 2GJG6@201174,4EU6R@85013,COG0647@1,COG0647@2 NA|NA|NA G Belongs to the HAD-like hydrolase superfamily MAG.T12.14_00682 1278078.G419_22134 0.0 1185.2 Nocardiaceae 3.6.3.8 ko:K01537 ko00000,ko01000 3.A.3.2 Bacteria 2GJJC@201174,4FU7Y@85025,COG0474@1,COG0474@2 NA|NA|NA P PFAM E1-E2 ATPase-associated domain protein, Haloacid dehalogenase domain protein hydrolase, cation transporting ATPase domain protein MAG.T12.14_00683 909613.UO65_3764 5.4e-175 620.5 Pseudonocardiales 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GJAC@201174,4DXDP@85010,COG0183@1,COG0183@2 NA|NA|NA I Belongs to the thiolase family MAG.T12.14_00684 909613.UO65_3763 2.2e-264 918.3 Pseudonocardiales fadB 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ50@201174,4E0TU@85010,COG1024@1,COG1024@2,COG1250@1,COG1250@2 NA|NA|NA I 3-hydroxyacyl-CoA dehydrogenase MAG.T12.14_00685 44060.JODL01000025_gene142 3.7e-39 168.3 Actinobacteria Bacteria 2GNIP@201174,COG1309@1,COG1309@2 NA|NA|NA K transcriptional regulator MAG.T12.14_00686 1211815.CBYP010000051_gene683 3.3e-20 105.5 Frankiales ko:K03265 ko03015,map03015 ko00000,ko00001,ko03012,ko03019 Bacteria 2IFQH@201174,4ET50@85013,COG1503@1,COG1503@2 NA|NA|NA J translation release factor activity MAG.T12.14_00688 796942.HMPREF9623_01830 2.7e-70 272.3 Clostridia Bacteria 1TSAT@1239,24A6W@186801,COG0535@1,COG0535@2 NA|NA|NA S radical SAM domain protein MAG.T12.14_00689 312284.A20C1_11546 4.9e-46 191.0 unclassified Actinobacteria (class) Bacteria 2HP5X@201174,3UXNT@52018,COG1309@1,COG1309@2 NA|NA|NA K WHG domain MAG.T12.14_00690 1304865.JAGF01000001_gene497 2.7e-72 278.9 Actinobacteria Bacteria 2GQC1@201174,COG2267@1,COG2267@2 NA|NA|NA I Alpha beta hydrolase MAG.T12.14_00691 1120960.ATXG01000004_gene1805 3.2e-87 328.6 Microbacteriaceae hutG 3.5.3.11,3.5.3.8 ko:K01479,ko:K01480 ko00330,ko00340,ko01100,map00330,map00340,map01100 M00045,M00133 R01157,R02285 RC00024,RC00221,RC00329,RC00681 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJA6@201174,4FKS9@85023,COG0010@1,COG0010@2 NA|NA|NA E Arginase family MAG.T12.14_00692 644283.Micau_1163 1.4e-143 516.2 Micromonosporales hutI GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006547,GO:0006548,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046395,GO:0046483,GO:0046700,GO:0052803,GO:0052805,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 3.5.2.7 ko:K01468 ko00340,ko01100,map00340,map01100 M00045 R02288 RC00683 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJH4@201174,4DBJ2@85008,COG1228@1,COG1228@2 NA|NA|NA Q hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides MAG.T12.14_00693 644283.Micau_1166 1.2e-260 905.6 Micromonosporales hutU 4.2.1.49 ko:K01712 ko00340,ko01100,map00340,map01100 M00045 R02914 RC00804 ko00000,ko00001,ko00002,ko01000 Bacteria 2GP10@201174,4D9Y2@85008,COG2987@1,COG2987@2 NA|NA|NA E Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate MAG.T12.14_00694 1192034.CAP_2819 1.4e-24 120.6 Myxococcales Bacteria 1NAQM@1224,2WNXU@28221,2YVQF@29,42RR6@68525,COG1946@1,COG1946@2 NA|NA|NA I Thioesterase-like superfamily MAG.T12.14_00695 471853.Bcav_1837 4.6e-179 634.4 Actinobacteria hutH 4.3.1.3 ko:K01745 ko00340,ko01100,map00340,map01100 M00045 R01168 RC00361 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJZW@201174,COG2986@1,COG2986@2 NA|NA|NA E Histidine ammonia-lyase MAG.T12.14_00696 1123320.KB889629_gene7866 3.3e-15 88.2 Actinobacteria Bacteria 2GVSD@201174,COG1714@1,COG1714@2 NA|NA|NA S RDD family MAG.T12.14_00697 494419.ALPM01000021_gene79 1.5e-113 417.2 Micrococcaceae Bacteria 1WB1I@1268,2GIZF@201174,COG5001@1,COG5001@2 NA|NA|NA T diguanylate cyclase MAG.T12.14_00698 188626.HMPREF0321_0345 2.3e-117 429.5 Dermacoccaceae deaD 3.6.4.13 ko:K05592,ko:K11927 ko03018,map03018 ko00000,ko00001,ko01000,ko03009,ko03019 Bacteria 1ZVH9@145357,2GIUR@201174,COG0513@1,COG0513@2 NA|NA|NA L helicase superfamily c-terminal domain MAG.T12.14_00699 1380370.JIBA01000005_gene614 2.9e-63 248.8 Intrasporangiaceae Bacteria 2IMQQ@201174,4FFD0@85021,COG2267@1,COG2267@2 NA|NA|NA I Serine aminopeptidase, S33 MAG.T12.14_00700 1313172.YM304_19260 3.4e-54 218.4 Acidimicrobiia Bacteria 2GKFS@201174,4CMYH@84992,COG0745@1,COG0745@2 NA|NA|NA K Transcriptional regulatory protein, C terminal MAG.T12.14_00701 1211815.CBYP010000036_gene2210 4e-62 245.7 Frankiales Bacteria 2GK1J@201174,4ERY7@85013,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor MAG.T12.14_00703 1172180.KB911793_gene3537 8.1e-107 393.7 Actinobacteria Bacteria 2GKRN@201174,COG2326@1,COG2326@2 NA|NA|NA G polyphosphate kinase MAG.T12.14_00704 926560.KE387023_gene3341 9.5e-85 320.9 Deinococcus-Thermus cyp132 1.14.15.24 ko:K22492 ko00906,map00906 R07558,R07559,R09747 RC00478,RC02629 ko00000,ko00001,ko00199,ko01000 Bacteria 1WIX6@1297,COG2124@1,COG2124@2 NA|NA|NA Q cytochrome P450 MAG.T12.14_00705 1306174.JODP01000006_gene3393 1.3e-28 132.9 Actinobacteria Bacteria 2IHPB@201174,COG0517@1,COG0517@2 NA|NA|NA S Cbs domain MAG.T12.14_00706 235985.BBPN01000033_gene11 4.3e-65 255.0 Streptacidiphilus Bacteria 2GKUU@201174,2NH2E@228398,COG3173@1,COG3173@2 NA|NA|NA S Phosphotransferase enzyme family MAG.T12.14_00708 1463841.JOIR01000009_gene4116 6.6e-78 297.4 Actinobacteria hisN GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.1.3.15 ko:K05602 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013 RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKZZ@201174,COG0483@1,COG0483@2 NA|NA|NA G inositol monophosphatase MAG.T12.14_00710 1385518.N798_08960 7.5e-106 390.6 Intrasporangiaceae rsgA 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 Bacteria 2GJ37@201174,4FEQ3@85021,COG1162@1,COG1162@2 NA|NA|NA S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit MAG.T12.14_00711 1429046.RR21198_0802 2.9e-142 511.9 Nocardiaceae aroA GO:0003674,GO:0003824,GO:0003866,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:0071944,GO:1901576 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJKX@201174,4FU48@85025,COG0128@1,COG0128@2 NA|NA|NA E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate MAG.T12.14_00712 469371.Tbis_2926 1.1e-66 260.0 Pseudonocardiales Bacteria 2GKY8@201174,4E13E@85010,COG2135@1,COG2135@2 NA|NA|NA S Belongs to the SOS response-associated peptidase family MAG.T12.14_00713 479435.Kfla_6453 1.5e-23 115.5 Propionibacteriales nuoD GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 ko:K00333,ko:K05579,ko:K13378 ko00190,ko01100,map00190,map01100 M00144,M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2GKEZ@201174,4DSY9@85009,COG0649@1,COG0649@2 NA|NA|NA C Belongs to the complex I 49 kDa subunit family MAG.T12.14_00714 1121926.AXWO01000013_gene2110 6.9e-07 60.1 Glycomycetales Bacteria 2E8UC@1,2GRUC@201174,3334W@2,4EYXG@85014 NA|NA|NA MAG.T12.14_00715 1246995.AFR_41455 3.7e-13 81.6 Micromonosporales Bacteria 2DRQG@1,2IFEG@201174,33CMQ@2,4DEJ0@85008 NA|NA|NA S Protein of unknown function (DUF3180) MAG.T12.14_00716 1348663.KCH_43430 2e-35 155.6 Kitasatospora folK 2.7.6.3,4.1.2.25 ko:K00950,ko:K13940 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503,R03504 RC00002,RC00017,RC00721,RC00943 ko00000,ko00001,ko00002,ko01000 Bacteria 2H3G6@201174,2M2ED@2063,COG0801@1,COG0801@2 NA|NA|NA H 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) MAG.T12.14_00717 1343740.M271_27135 4e-34 151.0 Actinobacteria folB GO:0008150,GO:0040007 1.13.11.81,2.7.6.3,4.1.2.25,5.1.99.8 ko:K01633,ko:K13940 ko00790,ko01100,map00790,map01100 M00126,M00840 R03503,R03504,R11037,R11073 RC00002,RC00017,RC00721,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 Bacteria 2IHSW@201174,COG1539@1,COG1539@2 NA|NA|NA H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin MAG.T12.14_00718 590998.Celf_0561 4.2e-89 334.7 Cellulomonadaceae folP 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJDQ@201174,4F0TG@85016,COG0294@1,COG0294@2 NA|NA|NA H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives MAG.T12.14_00719 743718.Isova_2655 5.5e-83 313.9 Promicromonosporaceae folE GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006082,GO:0006139,GO:0006575,GO:0006725,GO:0006729,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008616,GO:0009058,GO:0009108,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0019752,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042455,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901657,GO:1901659 2.7.6.3,3.5.4.16 ko:K00950,ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R03503,R04639,R05046,R05048 RC00002,RC00017,RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 iIT341.HP0928 Bacteria 2GP2P@201174,4F3XW@85017,COG0302@1,COG0302@2 NA|NA|NA H GTP cyclohydrolase I MAG.T12.14_00720 749414.SBI_05921 1.5e-262 912.1 Actinobacteria ftsH GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019222,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 ko:K03798 M00742 ko00000,ko00002,ko01000,ko01002,ko03110 Bacteria 2GJ4Q@201174,COG0465@1,COG0465@2 NA|NA|NA O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins MAG.T12.14_00721 1184607.AUCHE_03_01750 3.2e-74 284.6 Dermatophilaceae hpt 2.4.2.8,6.3.4.19 ko:K00760,ko:K04075,ko:K15780 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 R00190,R01132,R01229,R02142,R08237,R08238,R08245,R09597 RC00063,RC00122,RC02633,RC02634 ko00000,ko00001,ko01000,ko03016 Bacteria 2GMDZ@201174,4F64W@85018,COG0634@1,COG0634@2 NA|NA|NA F Phosphoribosyl transferase domain MAG.T12.14_00722 269800.Tfu_2897 1e-67 263.8 Streptosporangiales tilS 2.4.2.8,6.3.4.19 ko:K00760,ko:K04075,ko:K15780 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 R00190,R01132,R01229,R02142,R08237,R08238,R08245,R09597 RC00063,RC00122,RC02633,RC02634 ko00000,ko00001,ko01000,ko03016 Bacteria 2GJR4@201174,4EHNI@85012,COG0037@1,COG0037@2 NA|NA|NA D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine MAG.T12.14_00723 1210045.ALNP01000035_gene2435 1.5e-88 333.2 Actinobacteria Bacteria 2GJ8E@201174,COG5282@1,COG5282@2 NA|NA|NA S protein, coenzyme F420 biosynthesis associated MAG.T12.14_00724 1906.SFRA_18710 8.7e-63 248.1 Actinobacteria dacB 3.4.16.4 ko:K07259 ko00550,map00550 ko00000,ko00001,ko01000,ko01002,ko01011 Bacteria 2GJPH@201174,COG2027@1,COG2027@2 NA|NA|NA M D-alanyl-D-alanine carboxypeptidase MAG.T12.14_00725 66429.JOFL01000013_gene2959 6.5e-74 283.5 Actinobacteria ppa GO:0000287,GO:0003674,GO:0003824,GO:0004427,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0071944 3.6.1.1 ko:K01507 ko00190,map00190 ko00000,ko00001,ko01000 iNJ661.Rv3628 Bacteria 2GM7F@201174,COG0221@1,COG0221@2 NA|NA|NA C Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions MAG.T12.14_00726 1110697.NCAST_20_05770 7.5e-59 233.8 Nocardiaceae Bacteria 2IJG5@201174,4FVR0@85025,COG5587@1,COG5587@2 NA|NA|NA S Conserved hypothetical protein (DUF2461) MAG.T12.14_00727 1283283.ATXA01000005_gene2041 8.4e-190 670.6 Frankiales Bacteria 2GK30@201174,4ES04@85013,COG3973@1,COG3973@2 NA|NA|NA L DNA helicase MAG.T12.14_00728 40571.JOEA01000010_gene3037 3.6e-73 281.6 Pseudonocardiales ycbB ko:K00786 ko00000,ko01000 Bacteria 2I2J1@201174,4DXD3@85010,COG1216@1,COG1216@2 NA|NA|NA S Glycosyl transferase family 2 MAG.T12.14_00729 1449044.JMLE01000005_gene690 1.4e-15 89.4 Actinobacteria XK27_09090 ko:K09153 ko00000 Bacteria 2GQZ0@201174,COG2456@1,COG2456@2 NA|NA|NA S Uncharacterized conserved protein (DUF2304) MAG.T12.14_00730 477641.MODMU_2240 2.1e-81 309.7 Frankiales Bacteria 2GN4Y@201174,4ETWR@85013,COG0628@1,COG0628@2 NA|NA|NA S AI-2E family transporter MAG.T12.14_00731 1121272.KB903249_gene2575 5.3e-45 188.0 Micromonosporales mpg GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.2.2.21 ko:K03652 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 2GNW1@201174,4DD25@85008,COG2094@1,COG2094@2 NA|NA|NA L Belongs to the DNA glycosylase MPG family MAG.T12.14_00732 32049.SYNPCC7002_A1469 4.9e-38 164.5 Synechococcus GO:0005575,GO:0005576,GO:0005615,GO:0044421 Bacteria 1G6R4@1117,1H17A@1129,COG2335@1,COG2335@2 NA|NA|NA M Fasciclin domain protein MAG.T12.14_00733 68570.DC74_256 1.6e-116 426.0 Actinobacteria ppk2 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005525,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006183,GO:0006464,GO:0006468,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009889,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0030808,GO:0031323,GO:0031326,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0036211,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044403,GO:0044419,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046777,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051704,GO:0055086,GO:0062012,GO:0065007,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0080090,GO:0090407,GO:0097159,GO:0097367,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.4.1 ko:K22468 ko00190,ko03018,map00190,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 2GKRN@201174,COG2326@1,COG2326@2 NA|NA|NA G polyphosphate kinase MAG.T12.14_00734 1394178.AWOO02000034_gene8339 2.1e-137 496.9 Streptosporangiales Bacteria 2GJAR@201174,4EG63@85012,COG2909@1,COG2909@2 NA|NA|NA K AAA ATPase domain MAG.T12.14_00736 58123.JOFJ01000012_gene5336 1.5e-31 144.1 Streptosporangiales Bacteria 2IBIC@201174,4EH95@85012,COG2199@1,COG3706@2 NA|NA|NA T diguanylate cyclase MAG.T12.14_00737 397278.JOJN01000001_gene2848 2.2e-81 309.7 Propionibacteriales Bacteria 2I9AH@201174,4DMZA@85009,COG1403@1,COG1403@2 NA|NA|NA V HNH nucleases MAG.T12.14_00740 446471.Xcel_1943 5.3e-101 375.6 Actinobacteria Bacteria 2I8CR@201174,COG0464@1,COG0464@2 NA|NA|NA O PFAM AAA ATPase central domain protein MAG.T12.14_00743 446471.Xcel_1946 1.3e-135 490.3 Actinobacteria Bacteria 2ERBG@1,2GPQE@201174,33IX4@2 NA|NA|NA MAG.T12.14_00744 446471.Xcel_1947 6.7e-116 424.9 Actinobacteria Bacteria 28Q0Z@1,2IAZ4@201174,2ZCJM@2 NA|NA|NA MAG.T12.14_00745 446471.Xcel_1948 5.6e-65 256.1 Actinobacteria ko:K02040,ko:K20276,ko:K21449 ko02010,ko02020,ko02024,ko05152,map02010,map02020,map02024,map05152 M00222 ko00000,ko00001,ko00002,ko02000 1.B.40.2,3.A.1.7 Bacteria 2IRA0@201174,COG4223@1,COG4223@2 NA|NA|NA M COG3209 Rhs family protein MAG.T12.14_00746 446471.Xcel_1949 5e-147 528.5 Actinobacteria Bacteria 2I52J@201174,COG3391@1,COG3391@2 NA|NA|NA S Phage tail protein (Tail_P2_I) MAG.T12.14_00747 446471.Xcel_1950 1.4e-217 762.7 Actinobacteria Bacteria 2GM5C@201174,COG3299@1,COG3299@2 NA|NA|NA S Baseplate J-like protein MAG.T12.14_00748 446471.Xcel_1951 2.4e-44 184.9 Actinobacteria ko:K06903 ko00000 Bacteria 2IFJ6@201174,COG3628@1,COG3628@2 NA|NA|NA S GPW gp25 family protein MAG.T12.14_00750 446471.Xcel_1953 2.2e-39 169.5 Actinobacteria Bacteria 2GP13@201174,COG3501@1,COG3501@2 NA|NA|NA S Rhs element Vgr protein MAG.T12.14_00751 446471.Xcel_1954 7.5e-137 493.8 Bacteria ko:K06905 ko00000 Bacteria COG3500@1,COG3500@2 NA|NA|NA MAG.T12.14_00752 446471.Xcel_1955 2e-73 282.3 Actinobacteria Bacteria 2IAAU@201174,COG1652@1,COG1652@2 NA|NA|NA S PFAM Peptidoglycan-binding MAG.T12.14_00754 379066.GAU_3439 2e-36 159.1 Bacteria Bacteria 2DMQT@1,32T2H@2 NA|NA|NA S T4-like virus tail tube protein gp19 MAG.T12.14_00755 446471.Xcel_1958 5.3e-180 637.9 Actinobacteria ko:K06907 ko00000 Bacteria 2IG6A@201174,COG3497@1,COG3497@2 NA|NA|NA S Phage tail sheath protein subtilisin-like domain MAG.T12.14_00756 446471.Xcel_1959 9e-56 223.0 Actinobacteria Bacteria 2DB76@1,2GKK0@201174,2Z7JZ@2 NA|NA|NA S T4-like virus tail tube protein gp19 MAG.T12.14_00757 446471.Xcel_1960 0.0 1248.0 Actinobacteria ko:K06907 ko00000 Bacteria 2GMJA@201174,COG3497@1,COG3497@2 NA|NA|NA S tail sheath protein MAG.T12.14_00758 446471.Xcel_1961 4.4e-07 61.6 Bacteria Bacteria 2EA5X@1,334AT@2 NA|NA|NA MAG.T12.14_00759 1463934.JOCF01000031_gene4812 9e-113 413.3 Actinobacteria oorB 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GMI5@201174,COG1013@1,COG1013@2 NA|NA|NA C Ferredoxin oxidoreductase MAG.T12.14_00760 1464048.JNZS01000019_gene2358 1.3e-48 200.3 Micromonosporales ko:K03294 ko00000 2.A.3.2 Bacteria 2GMFE@201174,4DD1H@85008,COG0589@1,COG0589@2 NA|NA|NA T Belongs to the universal stress protein A family MAG.T12.14_00761 285514.JNWO01000023_gene102 1.5e-79 303.1 Actinobacteria rarD ko:K05786 ko00000,ko02000 2.A.7.7 Bacteria 2GKCP@201174,COG2962@1,COG2962@2 NA|NA|NA S RarD protein MAG.T12.14_00762 1048339.KB913029_gene2590 2e-116 425.6 Frankiales hepS GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.5.1.30 ko:K00805 ko00900,ko01110,map00900,map01110 R09247 RC00279 ko00000,ko00001,ko01000,ko01006 Bacteria 2GMB4@201174,4ERU8@85013,COG0142@1,COG0142@2 NA|NA|NA H Belongs to the FPP GGPP synthase family MAG.T12.14_00763 1380347.JNII01000005_gene3065 1.8e-195 688.7 Frankiales trpB 4.2.1.20 ko:K01696,ko:K06001 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 Bacteria 2GP7D@201174,4ES9G@85013,COG1350@1,COG1350@2 NA|NA|NA E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine MAG.T12.14_00764 1123320.KB889574_gene5648 4.8e-152 544.7 Actinobacteria nuoN GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2GMGX@201174,COG1007@1,COG1007@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient MAG.T12.14_00765 471852.Tcur_4406 4e-167 594.7 Streptosporangiales nuoM GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0048037,GO:0048038,GO:0048039,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1902600,GO:1990204 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 iSDY_1059.SDY_2473 Bacteria 2GKBN@201174,4EH1X@85012,COG1008@1,COG1008@2 NA|NA|NA C Proton-conducting membrane transporter MAG.T12.14_00766 247156.NFA_26570 3.1e-225 788.1 Nocardiaceae nuoL GO:0008150,GO:0009605,GO:0009607,GO:0043207,GO:0044403,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0075136 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2GIT4@201174,4FWHS@85025,COG1009@1,COG1009@2 NA|NA|NA CP NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus MAG.T12.14_00767 1120936.KB907213_gene4917 2.1e-32 144.8 Streptosporangiales nuoK GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3 ko:K00340,ko:K05576 ko00190,ko01100,map00190,map01100 M00144,M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2IKV7@201174,4EJPX@85012,COG0713@1,COG0713@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient MAG.T12.14_00768 1194972.MVAC_02599 1.1e-65 256.9 Mycobacteriaceae nuoJ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 233A9@1762,2GKRS@201174,COG0839@1,COG0839@2 NA|NA|NA C Belongs to the complex I subunit 6 family MAG.T12.14_00769 1504319.GM45_4160 3.5e-68 264.6 unclassified Actinobacteria (class) nuoI GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.6.5.3 ko:K00337,ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 iNJ661.Rv3153 Bacteria 2GJNU@201174,3UWSS@52018,COG1143@1,COG1143@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient MAG.T12.14_00770 1504319.GM45_4155 4.1e-152 544.7 unclassified Actinobacteria (class) nuoH 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2GIVY@201174,3UW85@52018,COG1005@1,COG1005@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone MAG.T12.14_00771 1429046.RR21198_5847 5.6e-256 890.6 Nocardiaceae nuoG GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009405,GO:0010941,GO:0016020,GO:0016491,GO:0016651,GO:0030312,GO:0033668,GO:0035821,GO:0042981,GO:0043067,GO:0043069,GO:0044003,GO:0044068,GO:0044403,GO:0044419,GO:0044464,GO:0044531,GO:0044532,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051536,GO:0051540,GO:0051701,GO:0051704,GO:0051817,GO:0052040,GO:0052041,GO:0052150,GO:0052248,GO:0052433,GO:0052490,GO:0055114,GO:0060548,GO:0065007,GO:0071944 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2GJGX@201174,4FXK7@85025,COG1034@1,COG1034@2 NA|NA|NA C NADH-ubiquinone oxidoreductase-G iron-sulfur binding region MAG.T12.14_00772 1504319.GM45_4145 1.4e-184 652.5 unclassified Actinobacteria (class) nuoF 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2GMMC@201174,3UWD5@52018,COG1894@1,COG1894@2 NA|NA|NA C NADH-ubiquinone oxidoreductase-F iron-sulfur binding region MAG.T12.14_00773 1504319.GM45_4140 1.6e-64 252.7 unclassified Actinobacteria (class) nuoE GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3,1.6.99.3 ko:K00334,ko:K00335,ko:K03943 ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016 M00143,M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1,3.D.1.6 Bacteria 2GKG0@201174,3UWSV@52018,COG1905@1,COG1905@2 NA|NA|NA C Thioredoxin-like [2Fe-2S] ferredoxin MAG.T12.14_00774 1504319.GM45_4135 2e-194 685.3 unclassified Actinobacteria (class) nuoD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2GKEZ@201174,3UWKD@52018,COG0649@1,COG0649@2 NA|NA|NA C Belongs to the complex I 49 kDa subunit family MAG.T12.14_00775 1003195.SCAT_3486 1.1e-90 339.7 Actinobacteria nuoC GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0050136,GO:0055114 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2GIRH@201174,COG0852@1,COG0852@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient MAG.T12.14_00776 1504319.GM45_4125 2.3e-85 321.6 unclassified Actinobacteria (class) nuoB 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2GJXR@201174,3UWJQ@52018,COG0377@1,COG0377@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient MAG.T12.14_00777 436229.JOEH01000024_gene946 1.3e-50 205.7 Streptacidiphilus nuoA GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044464,GO:0050136,GO:0055114,GO:0071944,GO:0098796,GO:1902494 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2IKWT@201174,2NJ30@228398,COG0838@1,COG0838@2 NA|NA|NA C NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 MAG.T12.14_00778 1120950.KB892779_gene972 3.3e-138 498.4 Propionibacteriales 1.3.99.38 ko:K21401 ko00000,ko01000 Bacteria 2GKGH@201174,4DPE1@85009,COG0644@1,COG0644@2 NA|NA|NA C FAD binding domain MAG.T12.14_00779 479431.Namu_3208 0.0 1110.5 Actinobacteria pflB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006566,GO:0006567,GO:0006629,GO:0006631,GO:0006807,GO:0008150,GO:0008152,GO:0008861,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009987,GO:0016020,GO:0016054,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0016999,GO:0017144,GO:0019541,GO:0019752,GO:0032787,GO:0042737,GO:0043436,GO:0043875,GO:0044237,GO:0044238,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046459,GO:0070689,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.3.1.54 ko:K00656 ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120 R00212,R06987 RC00004,RC01181,RC02742,RC02833 ko00000,ko00001,ko01000 iECH74115_1262.ECH74115_1064,iECIAI39_1322.ECIAI39_2245,iECSP_1301.ECSP_1007,iECs_1301.ECs0986,iEcSMS35_1347.EcSMS35_2218,iEcSMS35_1347.EcSMS35_3410,iG2583_1286.G2583_1138,iSDY_1059.SDY_2358,iZ_1308.Z1248 Bacteria 2GTTT@201174,COG1882@1,COG1882@2 NA|NA|NA C formate acetyltransferase MAG.T12.14_00780 1463887.KL589953_gene93 2.6e-66 258.8 Actinobacteria pflA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0018307,GO:0019538,GO:0033554,GO:0036211,GO:0043170,GO:0043364,GO:0043365,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0055114,GO:0070283,GO:0071704,GO:1901564 1.97.1.4 ko:K04069 R04710 ko00000,ko01000 iECOK1_1307.ECOK1_0925,iEcE24377_1341.EcE24377A_0980,iEcSMS35_1347.EcSMS35_2219,iYL1228.KPN_00930 Bacteria 2GN2B@201174,COG1180@1,COG1180@2 NA|NA|NA C Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine MAG.T12.14_00781 452652.KSE_34280 2.3e-13 82.8 Kitasatospora Bacteria 2HRC6@201174,2M45I@2063,COG1280@1,COG1280@2 NA|NA|NA E Sap, sulfolipid-1-addressing protein MAG.T12.14_00782 1137269.AZWL01000015_gene734 2.8e-94 351.7 Actinobacteria ubiE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008425,GO:0008757,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016741,GO:0030580,GO:0032259,GO:0042180,GO:0042181,GO:0043333,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 iAF1260.b3833,iBWG_1329.BWG_3511,iE2348C_1286.E2348C_4147,iEC042_1314.EC042_4213,iEC55989_1330.EC55989_4310,iECDH10B_1368.ECDH10B_4024,iECDH1ME8569_1439.ECDH1ME8569_3712,iECH74115_1262.ECH74115_5274,iECIAI1_1343.ECIAI1_4028,iECIAI39_1322.ECIAI39_3162,iECO103_1326.ECO103_4330,iECO111_1330.ECO111_4661,iECO26_1355.ECO26_4752,iECSE_1348.ECSE_4121,iECSP_1301.ECSP_4888,iECUMN_1333.ECUMN_4359,iECW_1372.ECW_m4135,iECs_1301.ECs4763,iEKO11_1354.EKO11_4524,iETEC_1333.ETEC_4110,iEcDH1_1363.EcDH1_4146,iEcE24377_1341.EcE24377A_4354,iEcHS_1320.EcHS_A4057,iEcSMS35_1347.EcSMS35_4216,iEcolC_1368.EcolC_4175,iG2583_1286.G2583_4633,iJO1366.b3833,iJR904.b3833,iSBO_1134.SBO_3847,iSDY_1059.SDY_3910,iSFV_1184.SFV_3665,iSF_1195.SF3911,iSFxv_1172.SFxv_4263,iSSON_1240.SSON_4008,iS_1188.S3843,iSbBS512_1146.SbBS512_E4305,iUMNK88_1353.UMNK88_4663,iWFL_1372.ECW_m4135,iY75_1357.Y75_RS17910,iZ_1308.Z5355 Bacteria 2GKFZ@201174,COG0500@1,COG2226@2 NA|NA|NA H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) MAG.T12.14_00783 479435.Kfla_6301 1.6e-113 416.4 Propionibacteriales menF 2.6.1.85,4.1.3.27,5.4.4.2 ko:K01657,ko:K02552,ko:K13950 ko00130,ko00400,ko00405,ko00790,ko01053,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00130,map00400,map00405,map00790,map01053,map01100,map01110,map01130,map01230,map02024,map02025 M00023,M00116 R00985,R00986,R01716,R01717 RC00010,RC00588,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKE8@201174,4DPGF@85009,COG1169@1,COG1169@2 NA|NA|NA HQ Isochorismate synthase MAG.T12.14_00784 1356852.N008_18865 2.9e-14 84.7 Cytophagia Bacteria 47RW1@768503,4NUPH@976,COG0607@1,COG0607@2 NA|NA|NA P Rhodanese Homology Domain MAG.T12.14_00785 477641.MODMU_4977 3.2e-107 396.0 Frankiales menD GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 2.2.1.9 ko:K02551 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R08165 RC02186 ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS05085 Bacteria 2GMEB@201174,4ES4N@85013,COG1165@1,COG1165@2 NA|NA|NA H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) MAG.T12.14_00786 478801.Ksed_24140 1.6e-72 280.0 Dermacoccaceae menC GO:0008150,GO:0040007 4.2.1.113,5.1.1.20,5.1.1.3 ko:K01776,ko:K02549,ko:K19802 ko00130,ko00471,ko01100,ko01110,map00130,map00471,map01100,map01110 M00116 R00260,R04031,R10938 RC00302,RC01053,RC03309 ko00000,ko00001,ko00002,ko01000,ko01011 iNJ661.Rv0553,iSB619.SA_RS09080 Bacteria 1ZVR3@145357,2GJJR@201174,COG4948@1,COG4948@2 NA|NA|NA H Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) MAG.T12.14_00787 65497.JODV01000007_gene534 7.5e-129 466.8 Pseudonocardiales menB GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0008150,GO:0008152,GO:0008935,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0042180,GO:0042181,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:0071890,GO:1901576,GO:1901661,GO:1901663 4.1.3.36 ko:K01661 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R07263 RC01923 ko00000,ko00001,ko00002,ko01000 iJN678.menB,iYL1228.KPN_02660 Bacteria 2GK5G@201174,4E09A@85010,COG0447@1,COG0447@2 NA|NA|NA H Belongs to the enoyl-CoA hydratase isomerase family. MenB subfamily MAG.T12.14_00788 67373.JOBF01000006_gene2459 2.4e-36 159.1 Actinobacteria Bacteria 2GP92@201174,COG1309@1,COG1309@2 NA|NA|NA K transcriptional regulator MAG.T12.14_00789 1254432.SCE1572_32985 2.5e-21 110.2 Proteobacteria Bacteria 1N5ID@1224,COG3591@1,COG3591@2 NA|NA|NA E Belongs to the peptidase S1B family MAG.T12.14_00790 1120950.KB892720_gene1909 1.8e-100 372.9 Propionibacteriales nagA 3.5.1.25 ko:K01443 ko00520,ko01130,map00520,map01130 R02059 RC00166,RC00300 ko00000,ko00001,ko01000 iNJ661.Rv3332 Bacteria 2GK1E@201174,4DPBF@85009,COG1820@1,COG1820@2 NA|NA|NA G Belongs to the metallo-dependent hydrolases superfamily. NagA family MAG.T12.14_00791 1137269.AZWL01000012_gene2982 1e-115 423.7 Actinobacteria nagE 2.7.1.193,2.7.1.199 ko:K02803,ko:K02804,ko:K20116,ko:K20117,ko:K20118 ko00010,ko00520,ko02060,map00010,map00520,map02060 M00267,M00809 R02738,R05199 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.13,4.A.1.1.14,4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7,4.A.1.1.9 Bacteria 2GKPM@201174,COG1263@1,COG1263@2 NA|NA|NA G Phosphotransferase System MAG.T12.14_00792 471852.Tcur_4029 1.4e-18 98.6 Streptosporangiales 2.7.1.193 ko:K02803 ko00520,ko02060,map00520,map02060 M00267 R05199 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7 Bacteria 2IQIB@201174,4EKNU@85012,COG1264@1,COG1264@2 NA|NA|NA G phosphotransferase system, EIIB MAG.T12.14_00793 31964.CMS0913 1.7e-89 335.9 Microbacteriaceae nagB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.7.1.193,2.7.1.199,3.1.1.31,3.5.99.6 ko:K01057,ko:K02564,ko:K02802,ko:K02803,ko:K02804,ko:K20116,ko:K20117,ko:K20118 ko00010,ko00030,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko02060,map00010,map00030,map00520,map01100,map01110,map01120,map01130,map01200,map02060 M00004,M00006,M00008,M00267,M00809 R00765,R02035,R02738,R05199 RC00017,RC00163,RC00537,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.13,4.A.1.1.14,4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7,4.A.1.1.9 Bacteria 2GK7F@201174,4FK5H@85023,COG0363@1,COG0363@2,COG1263@1,COG1263@2 NA|NA|NA G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion MAG.T12.14_00794 526226.Gbro_2724 1.3e-82 313.2 Gordoniaceae ybhF GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015562,GO:0015893,GO:0016020,GO:0022857,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944 ko:K01990,ko:K01992,ko:K13926 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2ICIF@201174,4GGY6@85026,COG1131@1,COG1131@2 NA|NA|NA V AAA domain, putative AbiEii toxin, Type IV TA system MAG.T12.14_00795 1454010.JEOE01000004_gene138 1.9e-83 315.8 Cellulomonadaceae ybhF GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015562,GO:0015893,GO:0016020,GO:0022857,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944 ko:K01990,ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2IH64@201174,4F2FJ@85016,COG1131@1,COG1131@2 NA|NA|NA V ATPases associated with a variety of cellular activities MAG.T12.14_00796 644548.SCNU_19462 8.7e-129 466.8 Gordoniaceae ybhS ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GJ7Y@201174,4GCQ2@85026,COG0842@1,COG0842@2 NA|NA|NA U ABC-2 family transporter protein MAG.T12.14_00797 1273125.Rrhod_1412 8.9e-53 214.5 Nocardiaceae menE 6.2.1.26 ko:K01911 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R04030 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 Bacteria 2GN9C@201174,4FUUX@85025,COG0318@1,COG0318@2 NA|NA|NA IQ AMP-binding enzyme C-terminal domain MAG.T12.14_00798 1184609.KILIM_039_00360 6.1e-83 314.3 Dermatophilaceae menA GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006775,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009233,GO:0009234,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0032194,GO:0042180,GO:0042181,GO:0042362,GO:0042371,GO:0042373,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046428,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663 2.5.1.74 ko:K02548 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R05617,R06858,R10757 RC02935,RC02936,RC03264 ko00000,ko00001,ko00002,ko01000,ko01006 iECH74115_1262.ECH74115_5387,iG2583_1286.G2583_4737 Bacteria 2GJBS@201174,4F6JM@85018,COG1575@1,COG1575@2 NA|NA|NA H Belongs to the MenA family. Type 1 subfamily MAG.T12.14_00799 158189.SpiBuddy_1062 2.8e-50 204.9 Spirochaetes btuE 1.11.1.9 ko:K00432 ko00480,ko00590,ko04918,map00480,map00590,map04918 R00274,R07034,R07035 RC00011,RC00982 ko00000,ko00001,ko01000 Bacteria 2J843@203691,COG0386@1,COG0386@2 NA|NA|NA C Belongs to the glutathione peroxidase family MAG.T12.14_00800 1120950.KB892801_gene1792 6.1e-12 77.4 Propionibacteriales Bacteria 2EGDD@1,2HKYH@201174,33A58@2,4DSSA@85009 NA|NA|NA S Phospholipase_D-nuclease N-terminal MAG.T12.14_00802 1048339.KB913029_gene2342 2.2e-79 302.8 Frankiales ccsA GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008152,GO:0015886,GO:0016020,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0055114,GO:0071702,GO:0071705,GO:0071944,GO:1901678 Bacteria 2GJR1@201174,4ESE9@85013,COG0755@1,COG0755@2 NA|NA|NA O Cytochrome c-type biogenesis protein MAG.T12.14_00803 1120950.KB892801_gene1786 4.2e-127 461.8 Propionibacteriales resB ko:K07399 ko00000 Bacteria 2GMGH@201174,4DN12@85009,COG1333@1,COG1333@2 NA|NA|NA O ResB-like family MAG.T12.14_00804 1236902.ANAS01000019_gene4144 2.5e-73 282.3 Streptosporangiales ccdA ko:K06196 ko00000,ko02000 5.A.1.2 Bacteria 2GJW3@201174,4EHWN@85012,COG0785@1,COG0785@2 NA|NA|NA O Cytochrome C biogenesis protein transmembrane region MAG.T12.14_00805 269800.Tfu_2704 1.1e-43 183.3 Streptosporangiales resA ko:K02199 ko00000,ko03110 Bacteria 2GP7J@201174,4EJ9T@85012,COG0526@1,COG0526@2 NA|NA|NA CO Thioredoxin-like MAG.T12.14_00806 105420.BBPO01000037_gene311 2.5e-75 288.5 Streptacidiphilus GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 3.1.3.3,3.1.3.73 ko:K02226,ko:K22305 ko00260,ko00680,ko00860,ko01100,ko01120,ko01130,map00260,map00680,map00860,map01100,map01120,map01130 M00122 R00582,R04594,R11173 RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 2GMXF@201174,2NFB7@228398,COG0406@1,COG0406@2 NA|NA|NA G Phosphoglycerate mutase family MAG.T12.14_00807 656024.FsymDg_4039 1.5e-170 605.9 Frankiales hemL GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016853,GO:0016866,GO:0016869,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042286,GO:0042440,GO:0042802,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 iSB619.SA_RS08395,iUMNK88_1353.UMNK88_158 Bacteria 2GJSH@201174,4ERKP@85013,COG0001@1,COG0001@2 NA|NA|NA H PFAM Aminotransferase class-III MAG.T12.14_00808 446466.Cfla_3439 7e-99 367.1 Cellulomonadaceae hemB GO:0000287,GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 iECABU_c1320.ECABU_c04500,iEcSMS35_1347.EcSMS35_0398,iJN746.PP_2913,ic_1306.c0477 Bacteria 2GJJ0@201174,4F0TK@85016,COG0113@1,COG0113@2 NA|NA|NA H Belongs to the ALAD family MAG.T12.14_00809 1048339.KB913029_gene4568 6.2e-163 580.9 Frankiales ileS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iG2583_1286.G2583_0027,iPC815.YPO0475 Bacteria 2GK9M@201174,4ERW9@85013,COG0060@1,COG0060@2 NA|NA|NA J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) MAG.T12.14_00810 935866.JAER01000007_gene424 1.7e-41 177.2 Propionibacteriales Bacteria 2AUNZ@1,2GP4I@201174,31KBW@2,4DRN6@85009 NA|NA|NA S Protein of unknown function (DUF2786) MAG.T12.14_00811 1452536.JARE01000050_gene1860 1.7e-09 69.3 Microbacteriaceae wag31 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008360,GO:0009273,GO:0009987,GO:0016020,GO:0022603,GO:0022604,GO:0030312,GO:0031647,GO:0040007,GO:0042546,GO:0044085,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0050821,GO:0051128,GO:0060187,GO:0065007,GO:0065008,GO:0071554,GO:0071840,GO:0071944 Bacteria 2GMSC@201174,4FNCA@85023,COG3599@1,COG3599@2 NA|NA|NA D DivIVA protein MAG.T12.14_00812 1184609.KILIM_034_00410 1e-15 89.4 Dermatophilaceae yggT GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02221 ko00000,ko02044 Bacteria 2GQI1@201174,4F798@85018,COG0762@1,COG0762@2 NA|NA|NA S YGGT family MAG.T12.14_00813 1122611.KB903978_gene3351 7.6e-41 173.7 Streptosporangiales sepF GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0007049,GO:0008150,GO:0009987,GO:0016043,GO:0022402,GO:0022607,GO:0032506,GO:0042802,GO:0044085,GO:0051301,GO:0071840,GO:0090529 ko:K09772 ko00000,ko03036 Bacteria 2GNVH@201174,4EIJC@85012,COG1799@1,COG1799@2 NA|NA|NA D Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA MAG.T12.14_00814 58123.JOFJ01000001_gene3034 4.1e-66 258.1 Streptosporangiales yggS GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 ko:K06997 ko00000 Bacteria 2GMRJ@201174,4EGGM@85012,COG0325@1,COG0325@2 NA|NA|NA S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis MAG.T12.14_00815 882083.SacmaDRAFT_3694 1.9e-48 199.5 Pseudonocardiales yfiH GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016679,GO:0016682,GO:0030312,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0046983,GO:0055114,GO:0071944 ko:K05810 ko00000,ko01000 Bacteria 2GN1M@201174,4DZFD@85010,COG1496@1,COG1496@2 NA|NA|NA S Belongs to the multicopper oxidase YfiH RL5 family MAG.T12.14_00816 68223.JNZY01000002_gene5187 1e-154 553.1 Actinobacteria ftsZ GO:0000166,GO:0000287,GO:0000910,GO:0000921,GO:0000935,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022402,GO:0022607,GO:0030428,GO:0031106,GO:0032153,GO:0032155,GO:0032185,GO:0032506,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0045787,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051258,GO:0051301,GO:0051726,GO:0065003,GO:0065007,GO:0070925,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:1901265,GO:1901363 ko:K03531 ko04112,map04112 ko00000,ko00001,ko02048,ko03036,ko04812 Bacteria 2GJWC@201174,COG0206@1,COG0206@2 NA|NA|NA D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity MAG.T12.14_00817 446462.Amir_5761 3.2e-24 119.0 Pseudonocardiales ftsQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944 6.3.2.4 ko:K01921,ko:K03589,ko:K06438 ko00473,ko00550,ko01100,ko01502,ko04112,map00473,map00550,map01100,map01502,map04112 R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011,ko03036 Bacteria 2H4A4@201174,4E3DB@85010,COG1589@1,COG1589@2 NA|NA|NA D Cell division protein FtsQ MAG.T12.14_00818 1048339.KB913029_gene4575 2.1e-138 499.2 Frankiales murC GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 Bacteria 2I2E7@201174,4ERUC@85013,COG0773@1,COG0773@2 NA|NA|NA M Belongs to the MurCDEF family MAG.T12.14_00819 1288083.AUKR01000001_gene1241 6.3e-119 434.1 Actinobacteria murG 2.4.1.227,6.3.2.8 ko:K01924,ko:K02563 ko00471,ko00550,ko01100,ko01502,ko04112,map00471,map00550,map01100,map01502,map04112 R03193,R05032,R05662 RC00005,RC00049,RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 GT28 iLJ478.TM0232 Bacteria 2GJEM@201174,COG0707@1,COG0707@2 NA|NA|NA M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) MAG.T12.14_00820 1120950.KB892707_gene4889 2.9e-91 342.4 Propionibacteriales ftsW GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008360,GO:0009987,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032153,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051179,GO:0051234,GO:0051301,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:1901264,GO:1901505 2.4.1.227 ko:K02563,ko:K03588 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011,ko02000,ko03036 2.A.103.1 GT28 Bacteria 2GKXP@201174,4DNHR@85009,COG0772@1,COG0772@2 NA|NA|NA D Belongs to the SEDS family MAG.T12.14_00821 1048339.KB913029_gene4578 1.3e-148 533.1 Frankiales murD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 iNJ661.Rv2155c Bacteria 2GJZA@201174,4ERI0@85013,COG0771@1,COG0771@2 NA|NA|NA M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) MAG.T12.14_00822 1504319.GM45_1105 4.5e-117 427.9 unclassified Actinobacteria (class) mraY GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 iAF987.Gmet_0409,iEC042_1314.EC042_0088,iECABU_c1320.ECABU_c00920,iECED1_1282.ECED1_0088,iECH74115_1262.ECH74115_0095,iECSP_1301.ECSP_0090,iECs_1301.ECs0091,iG2583_1286.G2583_0091,iSDY_1059.SDY_0117,iZ_1308.Z0097,ic_1306.c0105 Bacteria 2GNEH@201174,3UWA7@52018,COG0472@1,COG0472@2 NA|NA|NA M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan MAG.T12.14_00823 146922.JOFU01000006_gene2820 3.6e-135 488.4 Actinobacteria murF 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 Bacteria 2GK0Y@201174,COG0770@1,COG0770@2 NA|NA|NA M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein MAG.T12.14_00824 1120950.KB892707_gene4885 5.2e-143 514.6 Propionibacteriales murE GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.10,6.3.2.13 ko:K01928,ko:K15792 ko00300,ko00550,map00300,map00550 R02788,R04617 RC00064,RC00090,RC00141 ko00000,ko00001,ko01000,ko01011 iNJ661.Rv2158c Bacteria 2GIS2@201174,4DN64@85009,COG0769@1,COG0769@2 NA|NA|NA M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan MAG.T12.14_00825 1504319.GM45_1090 1.4e-139 503.4 unclassified Actinobacteria (class) ftsI GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008144,GO:0008150,GO:0008658,GO:0008955,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0031224,GO:0031226,GO:0031406,GO:0032153,GO:0033218,GO:0033293,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:1901363,GO:1901681 3.4.16.4 ko:K03587,ko:K08384,ko:K08724,ko:K12552,ko:K12556 ko00550,ko01100,ko01501,map00550,map01100,map01501 ko00000,ko00001,ko01000,ko01011,ko03036 iSSON_1240.SSON_0092 Bacteria 2GKHH@201174,3UWG5@52018,COG0768@1,COG0768@2 NA|NA|NA M Penicillin-binding Protein dimerisation domain MAG.T12.14_00826 479435.Kfla_2879 3.2e-14 85.9 Propionibacteriales ftsL ko:K05589,ko:K12065 ko00000,ko02044,ko03036 3.A.7.11.1 Bacteria 2GW5Q@201174,4DS2Z@85009,COG2919@1,COG2919@2 NA|NA|NA D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic MAG.T12.14_00827 65497.JODV01000002_gene4329 2.2e-107 395.6 Pseudonocardiales rsmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 ko:K03438 ko00000,ko01000,ko03009 Bacteria 2GJGK@201174,4DZ61@85010,COG0275@1,COG0275@2 NA|NA|NA M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA MAG.T12.14_00829 1504319.GM45_1075 2.9e-43 181.4 unclassified Actinobacteria (class) mraZ GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0040007,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 ko:K03925 ko00000 Bacteria 2IHUB@201174,3UWSJ@52018,COG2001@1,COG2001@2 NA|NA|NA K MraZ protein, putative antitoxin-like MAG.T12.14_00830 994479.GL877879_gene5041 1.3e-67 262.7 Pseudonocardiales Bacteria 2GN4R@201174,4DZ99@85010,COG2030@1,COG2030@2 NA|NA|NA I MaoC like domain MAG.T12.14_00831 67352.JODS01000001_gene448 2.1e-105 389.0 Actinobacteria yeaC ko:K03924 ko00000,ko01000 Bacteria 2GK07@201174,COG0714@1,COG0714@2 NA|NA|NA S associated with various cellular activities MAG.T12.14_00832 1463936.JOJI01000017_gene7472 7.2e-45 188.3 Actinobacteria Bacteria 2GIWE@201174,COG1721@1,COG1721@2 NA|NA|NA J protein some members contain a von Willebrand factor type A vWA domain MAG.T12.14_00833 105425.BBPL01000031_gene4387 1.6e-64 254.6 Streptacidiphilus Bacteria 2HQBB@201174,2NFSB@228398,COG1305@1,COG1305@2 NA|NA|NA E Transglutaminase/protease-like homologues MAG.T12.14_00834 1449355.JQNR01000003_gene273 2.7e-55 222.2 Actinobacteria yvaK 3.1.1.1 ko:K03928 ko00000,ko01000 Bacteria 2GM1Y@201174,COG1647@1,COG1647@2 NA|NA|NA S Esterase MAG.T12.14_00835 55952.BU52_09430 6.2e-22 110.5 Actinobacteria Bacteria 2E49S@1,2I83P@201174,32RRE@2 NA|NA|NA S Protein of unknown function (DUF3040) MAG.T12.14_00836 1172188.KB911827_gene4382 3e-136 491.9 Intrasporangiaceae dinB 2.7.7.7 ko:K02346 ko00000,ko01000,ko03400 Bacteria 2GKBI@201174,4FE61@85021,COG0389@1,COG0389@2 NA|NA|NA L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII MAG.T12.14_00837 1121017.AUFG01000001_gene3000 0.0 1368.2 Intrasporangiaceae dnaE2 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 2GJ1P@201174,4FEK0@85021,COG0587@1,COG0587@2 NA|NA|NA L Belongs to the DNA polymerase type-C family. DnaE2 subfamily MAG.T12.14_00838 1380356.JNIK01000021_gene4429 6.4e-27 127.1 Frankiales Bacteria 2CGM3@1,2GP7H@201174,32S47@2,4ET5Q@85013 NA|NA|NA MAG.T12.14_00839 1123320.KB889675_gene3873 1.9e-20 105.1 Actinobacteria Bacteria 2ERD0@1,2GVR1@201174,33IYN@2 NA|NA|NA MAG.T12.14_00840 1146883.BLASA_0920 3e-69 268.5 Frankiales crtA 1.14.15.9 ko:K09847 ko00906,ko01100,map00906,map01100 R07525,R07526,R07537,R07538 RC02084 ko00000,ko00001,ko01000 Bacteria 29UQ5@1,2II02@201174,30G1W@2,4EV3Q@85013 NA|NA|NA C spheroidene monooxygenase MAG.T12.14_00842 1048339.KB913029_gene4359 1.3e-49 203.4 Frankiales 5.5.1.19 ko:K22502 ko00906,map00906 R03824,R05341 RC01004 ko00000,ko00001,ko01000 Bacteria 2IIUJ@201174,4EVC1@85013,COG2324@1,COG2324@2 NA|NA|NA S Carotenoid biosynthesis protein MAG.T12.14_00843 266940.Krad_3224 2.5e-92 345.9 Actinobacteria ko:K14597 ko00906,map00906 R07544,R07546 RC00262 ko00000,ko00001 Bacteria 2GJZI@201174,COG1215@1,COG1215@2 NA|NA|NA M Glycosyl transferase, family 2 MAG.T12.14_00844 1380356.JNIK01000013_gene4257 1.7e-170 605.9 Frankiales crtD 1.3.99.26,1.3.99.27,1.3.99.28,1.3.99.29,1.3.99.31,5.4.99.9 ko:K01854,ko:K09845,ko:K10027 ko00052,ko00520,ko00906,ko01100,ko01110,map00052,map00520,map00906,map01100,map01110 R00505,R04787,R04798,R04800,R07517,R07520,R07523,R07534,R09009,R09691,R09692 RC00317,RC01214,RC02080,RC02088,RC02396,RC02605 ko00000,ko00001,ko01000 Bacteria 2GJAV@201174,4ETTQ@85013,COG1233@1,COG1233@2 NA|NA|NA Q Flavin containing amine oxidoreductase MAG.T12.14_00845 1246995.AFR_10060 1.1e-119 437.2 Micromonosporales cvrA ko:K11105 ko00000,ko02000 2.A.36.6 Bacteria 2GJ9B@201174,4D9E3@85008,COG3263@1,COG3263@2 NA|NA|NA P Sodium/hydrogen exchanger family MAG.T12.14_00846 326424.FRAAL2165 2.4e-41 175.6 Frankiales 2.7.8.5 ko:K00995 ko00564,ko01100,map00564,map01100 R01801 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 Bacteria 2IDSP@201174,4ET6D@85013,COG0558@1,COG0558@2 NA|NA|NA I CDP-alcohol phosphatidyltransferase MAG.T12.14_00847 1380347.JNII01000005_gene3165 8.8e-25 120.6 Frankiales ko:K09807 ko00000 Bacteria 2GM1U@201174,4ET95@85013,COG2968@1,COG2968@2 NA|NA|NA S Protein of unknown function (DUF541) MAG.T12.14_00848 1048339.KB913029_gene4363 5.3e-100 370.9 Frankiales metF GO:0003674,GO:0003824,GO:0004489,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJTN@201174,4ERKZ@85013,COG0685@1,COG0685@2 NA|NA|NA E Methylenetetrahydrofolate reductase MAG.T12.14_00849 1123320.KB889675_gene3878 3.8e-108 398.3 Actinobacteria idsA 2.5.1.1,2.5.1.10,2.5.1.29 ko:K13787 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00365 R01658,R02003,R02061 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 Bacteria 2GJEK@201174,COG0142@1,COG0142@2 NA|NA|NA H Belongs to the FPP GGPP synthase family MAG.T12.14_00850 1504319.GM45_1000 9.1e-201 706.4 unclassified Actinobacteria (class) crtI 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 ko:K10027 ko00906,ko01100,ko01110,map00906,map01100,map01110 R04787,R04798,R04800,R09691,R09692 RC01214,RC02088,RC02605 ko00000,ko00001,ko01000 Bacteria 2GJAV@201174,3UXB3@52018,COG1233@1,COG1233@2 NA|NA|NA Q Flavin containing amine oxidoreductase MAG.T12.14_00851 1121019.AUMN01000024_gene3573 7.3e-84 318.2 Micrococcaceae ko:K14337,ko:K14339 ko00000,ko01000,ko01003 Bacteria 1WCDZ@1268,2AMJ0@1,2I3ZG@201174,31CER@2 NA|NA|NA MAG.T12.14_00852 1155718.KB891896_gene2107 4.6e-13 81.3 Actinobacteria Bacteria 2IKZ0@201174,COG2732@1,COG2732@2 NA|NA|NA K Barstar (barnase inhibitor) MAG.T12.14_00853 29306.JOBE01000002_gene2854 2.8e-28 131.7 Actinobacteria 3.1.27.3 ko:K01167,ko:K15125 ko05133,map05133 ko00000,ko00001,ko00536,ko01000,ko03016,ko03019 Bacteria 2IHPV@201174,COG4290@1,COG4290@2 NA|NA|NA F Ribonuclease MAG.T12.14_00854 1504319.GM45_0995 1.4e-90 339.7 unclassified Actinobacteria (class) crtB GO:0003674,GO:0003824,GO:0004337,GO:0004659,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016108,GO:0016109,GO:0016114,GO:0016116,GO:0016117,GO:0016740,GO:0016765,GO:0016767,GO:0042440,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046148,GO:0071704,GO:1901576 2.5.1.21,2.5.1.32,2.5.1.96,2.5.1.99 ko:K00801,ko:K02291,ko:K10208 ko00100,ko00906,ko00909,ko01062,ko01100,ko01110,ko01130,map00100,map00906,map00909,map01062,map01100,map01110,map01130 M00097 R00702,R02065,R02872,R04218,R06223,R07270,R07652,R09793,R10177 RC00362,RC00796,RC01101,RC02839,RC02869 ko00000,ko00001,ko00002,ko01000,ko01006 Bacteria 2HFT6@201174,3UXMW@52018,COG1562@1,COG1562@2 NA|NA|NA I Squalene/phytoene synthase MAG.T12.14_00855 1246995.AFR_09710 1.2e-25 123.2 Micromonosporales Bacteria 2E9MI@1,2IMX9@201174,333U6@2,4DG5M@85008 NA|NA|NA S lycopene cyclase MAG.T12.14_00856 134676.ACPL_1706 2e-29 135.6 Micromonosporales crtY Bacteria 2CPEY@1,2I84R@201174,32SIY@2,4DFG6@85008 NA|NA|NA S lycopene cyclase domain MAG.T12.14_00857 1463841.JOIR01000003_gene5736 7.8e-21 107.5 Actinobacteria fprE 1.18.1.3,1.7.1.15 ko:K00362,ko:K00529 ko00071,ko00360,ko00910,ko01120,ko01220,map00071,map00360,map00910,map01120,map01220 M00530,M00545 R00787,R02000,R06782,R06783 RC00098,RC00176 br01602,ko00000,ko00001,ko00002,ko01000 Bacteria 2GJKT@201174,COG0446@1,COG0446@2 NA|NA|NA Q pyridine nucleotide-disulphide oxidoreductase MAG.T12.14_00858 1306174.JODP01000009_gene6554 6.6e-65 254.6 Actinobacteria ko:K12510 ko00000,ko02044 Bacteria 2H577@201174,COG4965@1,COG4965@2 NA|NA|NA U Type ii secretion system MAG.T12.14_00859 1122609.AUGT01000012_gene4249 6.4e-67 261.2 Propionibacteriales ko:K12511 ko00000,ko02044 Bacteria 2GK7B@201174,4DR34@85009,COG2064@1,COG2064@2 NA|NA|NA NU Type II secretion system MAG.T12.14_00862 367299.JOEE01000003_gene2964 7.9e-32 145.2 Intrasporangiaceae Bacteria 2ICX6@201174,4FF5W@85021,COG1287@1,COG1287@2 NA|NA|NA S oligosaccharyl transferase activity MAG.T12.14_00863 471852.Tcur_2117 1.2e-33 151.0 Streptosporangiales Bacteria 2GN1J@201174,4EJA0@85012,COG5650@1,COG5650@2 NA|NA|NA S Glycosyltransferase family 87 MAG.T12.14_00864 2074.JNYD01000016_gene4254 3.9e-21 109.4 Pseudonocardiales ko:K13671 ko00000,ko01000,ko01003 GT87 Bacteria 2GJBC@201174,4E0FQ@85010,COG5650@1,COG5650@2 NA|NA|NA S Glycosyltransferase family 87 MAG.T12.14_00865 211114.JOEF01000026_gene262 1.1e-20 107.8 Pseudonocardiales ko:K13671 ko00000,ko01000,ko01003 GT87 Bacteria 2GJBC@201174,4DZJI@85010,COG5650@1,COG5650@2 NA|NA|NA S Glycosyltransferase family 87 MAG.T12.14_00866 479432.Sros_8386 1.4e-63 250.0 Streptosporangiales Bacteria 2GM96@201174,4EI1R@85012,COG2267@1,COG2267@2 NA|NA|NA I Serine aminopeptidase, S33 MAG.T12.14_00867 285535.JOEY01000001_gene5229 5e-60 237.7 Actinobacteria Bacteria 2GVM5@201174,COG1309@1,COG1309@2 NA|NA|NA K transcriptional regulator MAG.T12.14_00868 477641.MODMU_4652 2.5e-14 84.3 Frankiales Bacteria 2E3M2@1,2GQQW@201174,32YJA@2,4ETF4@85013 NA|NA|NA S Protein of unknown function (DUF3107) MAG.T12.14_00869 452652.KSE_48740 2.5e-60 238.8 Kitasatospora GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0071771 1.16.3.1,4.1.99.5 ko:K03594,ko:K14331 ko00860,map00860 R00078 RC02758 ko00000,ko00001,ko01000 Bacteria 2I2E1@201174,2M2BB@2063,COG1633@1,COG1633@2 NA|NA|NA S tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like MAG.T12.14_00870 1155714.KB891987_gene2874 6.5e-170 604.0 Actinobacteria deaD 3.6.4.13 ko:K05592,ko:K11927 ko03018,map03018 ko00000,ko00001,ko01000,ko03009,ko03019 Bacteria 2GIUR@201174,COG0513@1,COG0513@2 NA|NA|NA L Belongs to the DEAD box helicase family MAG.T12.14_00871 1048339.KB913029_gene2907 3.7e-13 80.9 Frankiales Bacteria 2C4RB@1,2HAZK@201174,2ZVRN@2,4EWZ7@85013 NA|NA|NA MAG.T12.14_00872 1048339.KB913029_gene2906 4.1e-99 367.9 Frankiales soj ko:K03496 ko00000,ko03036,ko04812 Bacteria 2GNEQ@201174,4EUFG@85013,COG1192@1,COG1192@2 NA|NA|NA D Cellulose biosynthesis protein BcsQ MAG.T12.14_00873 1449346.JQMO01000003_gene3193 4.6e-43 181.8 Kitasatospora Bacteria 2GKPK@201174,2M0AS@2063,COG2267@1,COG2267@2 NA|NA|NA I Serine aminopeptidase, S33 MAG.T12.14_00874 1906.SFRA_14425 2.5e-18 98.6 Actinobacteria prpE2 Bacteria 2GK8P@201174,COG0642@1,COG0642@2,COG2208@1,COG2208@2 NA|NA|NA T protein phosphatase 2C domain protein MAG.T12.14_00875 397278.JOJN01000006_gene1006 2.9e-50 206.1 Propionibacteriales 3.1.1.29 ko:K01056 ko00000,ko01000,ko03012 Bacteria 2HVQW@201174,4DQVN@85009,COG4427@1,COG4427@2 NA|NA|NA S Uncharacterized protein conserved in bacteria (DUF2332) MAG.T12.14_00876 1288083.AUKR01000008_gene1615 5.7e-177 627.1 Actinobacteria Bacteria 2GIX8@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase MAG.T12.14_00877 1048339.KB913029_gene2897 2.2e-147 528.5 Frankiales mcl1 4.1.3.24,4.1.3.25,4.1.3.34,5.4.99.63 ko:K01644,ko:K08691,ko:K14447,ko:K18292 ko00630,ko00660,ko00680,ko00720,ko01100,ko01120,ko01200,ko02020,map00630,map00660,map00680,map00720,map01100,map01120,map01200,map02020 M00346,M00373,M00376 R00237,R00362,R00473,R00934,R09292 RC00067,RC00307,RC00308,RC00311,RC00407,RC00502,RC01118,RC01205,RC02835 ko00000,ko00001,ko00002,ko01000 Bacteria 2GK5J@201174,4ESAE@85013,COG0697@1,COG0697@2,COG2301@1,COG2301@2 NA|NA|NA G Belongs to the HpcH HpaI aldolase family MAG.T12.14_00878 1283283.ATXA01000005_gene2174 3.3e-68 265.4 Frankiales Bacteria 2I198@201174,4ESMN@85013,COG0697@1,COG0697@2 NA|NA|NA EG EamA-like transporter family MAG.T12.14_00879 351607.Acel_1818 1.5e-108 399.8 Frankiales mgtE Bacteria 2GMMK@201174,4ERJN@85013,COG2239@1,COG2239@2 NA|NA|NA P CBS domain MAG.T12.14_00880 253839.SSNG_04680 7.3e-52 210.3 Actinobacteria Bacteria 2GJRV@201174,COG4420@1,COG4420@2 NA|NA|NA S membrane MAG.T12.14_00881 743718.Isova_1998 4e-278 964.1 Promicromonosporaceae glgP GO:0000272,GO:0003674,GO:0003824,GO:0004645,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0005977,GO:0005980,GO:0006073,GO:0006091,GO:0006112,GO:0008144,GO:0008150,GO:0008152,GO:0008184,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0015980,GO:0016052,GO:0016740,GO:0016757,GO:0016758,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901575 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 R02111 ko00000,ko00001,ko01000 GT35 Bacteria 2GIVZ@201174,4F4ZX@85017,COG0058@1,COG0058@2 NA|NA|NA G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties MAG.T12.14_00882 1463856.JOHY01000039_gene1645 6.4e-138 497.3 Actinobacteria mrp GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 ko:K03593 ko00000,ko03029,ko03036 Bacteria 2GJUZ@201174,COG0489@1,COG0489@2 NA|NA|NA D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP MAG.T12.14_00883 269800.Tfu_0381 5e-08 64.7 Streptosporangiales tatB GO:0008150,GO:0040007 ko:K03116,ko:K03117 ko03060,ko03070,map03060,map03070 M00336 ko00000,ko00001,ko00002,ko02044 2.A.64 Bacteria 2IR0U@201174,4EKBD@85012,COG1826@1,COG1826@2 NA|NA|NA U mttA/Hcf106 family MAG.T12.14_00884 1223523.H340_31413 1e-87 330.9 Actinobacteria 3.4.21.107 ko:K04771,ko:K08372 ko01503,ko02020,map01503,map02020 M00728 ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 Bacteria 2GJ96@201174,COG0265@1,COG0265@2 NA|NA|NA O Peptidase s1 and s6 chymotrypsin hap MAG.T12.14_00885 1283287.KB822583_gene2793 1.3e-66 259.6 Propionibacteriales safC GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 Bacteria 2GPEV@201174,4DNEI@85009,COG4122@1,COG4122@2 NA|NA|NA S O-methyltransferase MAG.T12.14_00886 1394178.AWOO02000057_gene737 2e-99 369.8 Streptosporangiales 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 Bacteria 2GJRB@201174,4EFVT@85012,COG0260@1,COG0260@2 NA|NA|NA E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides MAG.T12.14_00887 561175.KB894095_gene2192 4.3e-19 99.8 Streptosporangiales Bacteria 2E39N@1,2GQFF@201174,32Y97@2,4EKN2@85012 NA|NA|NA S Protein of unknown function (DUF3117) MAG.T12.14_00888 1380393.JHVP01000007_gene4322 6.6e-25 120.6 Frankiales Bacteria 2II8Y@201174,4ETJ6@85013,COG3427@1,COG3427@2 NA|NA|NA S Polyketide cyclase / dehydrase and lipid transport MAG.T12.14_00889 479433.Caci_7945 1.3e-07 62.4 Bacteria Bacteria COG3599@1,COG3599@2 NA|NA|NA D regulation of cell shape MAG.T12.14_00890 1343740.M271_18215 1.9e-105 389.0 Actinobacteria folP2 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJNI@201174,COG0294@1,COG0294@2 NA|NA|NA H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives MAG.T12.14_00891 1229203.KI301992_gene1914 9.4e-96 356.7 unclassified Actinobacteria (class) fmt2 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 Bacteria 2GKJH@201174,3UXFN@52018,COG1611@1,COG1611@2 NA|NA|NA S Possible lysine decarboxylase MAG.T12.14_00892 298654.FraEuI1c_2189 2.5e-55 221.9 Frankiales yceI Bacteria 2GJUB@201174,4ESN7@85013,COG2353@1,COG2353@2 NA|NA|NA S Belongs to the UPF0312 family MAG.T12.14_00893 1003195.SCAT_3996 1.9e-123 449.1 Actinobacteria dapE GO:0008150,GO:0040007 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 Bacteria 2GK09@201174,COG0624@1,COG0624@2 NA|NA|NA E succinyl-diaminopimelate desuccinylase MAG.T12.14_00894 1210045.ALNP01000010_gene1189 1.1e-103 383.3 Actinobacteria dapD GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008666,GO:0016020,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016749,GO:0030312,GO:0031402,GO:0031420,GO:0040007,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0048037,GO:0050662,GO:0071944 2.3.1.117 ko:K00674 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04365 RC00004,RC01136 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1201c Bacteria 2GIZ9@201174,COG2171@1,COG2171@2 NA|NA|NA E Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA MAG.T12.14_00896 1122611.KB903974_gene2937 6.8e-36 157.1 Streptosporangiales Bacteria 2GMPH@201174,4EJKB@85012,COG1853@1,COG1853@2 NA|NA|NA S Flavin reductase like domain MAG.T12.14_00897 1120950.KB892823_gene520 1.3e-94 354.0 Propionibacteriales vanW Bacteria 2GISH@201174,4DN8K@85009,COG2720@1,COG2720@2 NA|NA|NA V Putative peptidoglycan binding domain MAG.T12.14_00898 1184609.KILIM_030_00650 7.1e-50 203.0 Dermatophilaceae fdxA ko:K05524 ko00000 Bacteria 2IKVN@201174,4F715@85018,COG1146@1,COG1146@2 NA|NA|NA C 4Fe-4S binding domain MAG.T12.14_00899 1246995.AFR_38740 3.3e-133 481.5 Micromonosporales dapC Bacteria 2GJMI@201174,4DB04@85008,COG0436@1,COG0436@2 NA|NA|NA E Aminotransferase MAG.T12.14_00900 253839.SSNG_00156 4.2e-70 271.2 Actinobacteria Bacteria 2DKWQ@1,2I3CS@201174,30MQE@2 NA|NA|NA S Glyoxalase-like domain MAG.T12.14_00901 1386089.N865_11735 1.1e-181 642.9 Intrasporangiaceae gltA 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ7E@201174,4FEQ1@85021,COG0372@1,COG0372@2 NA|NA|NA C Belongs to the citrate synthase family MAG.T12.14_00902 266940.Krad_1135 1e-196 693.3 Actinobacteria ftsH ko:K03798 M00742 ko00000,ko00002,ko01000,ko01002,ko03110 Bacteria 2I9X7@201174,COG0465@1,COG0465@2 NA|NA|NA O Belongs to the AAA ATPase family MAG.T12.14_00903 68223.JNZY01000001_gene5613 6.6e-75 287.3 Actinobacteria ppgK 2.7.1.2,2.7.1.63 ko:K00845,ko:K00886 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786,R02187,R02189 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJA0@201174,COG1940@1,COG1940@2 NA|NA|NA GK polyphosphate glucokinase MAG.T12.14_00904 1449353.JQMQ01000005_gene2404 1.1e-97 363.2 Streptacidiphilus mshB 3.5.1.103 ko:K15525 ko00000,ko01000 Bacteria 2GKUM@201174,2NET5@228398,COG2120@1,COG2120@2 NA|NA|NA S GlcNAc-PI de-N-acetylase MAG.T12.14_00905 1048339.KB913029_gene2175 4e-27 129.0 Frankiales bldKE ko:K02032,ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 2H4BW@201174,4EUB4@85013,COG4608@1,COG4608@2 NA|NA|NA P Oligopeptide/dipeptide transporter, C-terminal region MAG.T12.14_00906 66377.JOBH01000017_gene2936 1e-121 443.4 Actinobacteria ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 2H4BW@201174,COG4608@1,COG4608@2 NA|NA|NA E Belongs to the ABC transporter superfamily MAG.T12.14_00907 1122138.AQUZ01000074_gene7343 2.3e-42 178.3 Propionibacteriales Bacteria 2DWJQ@1,2IMTZ@201174,340PJ@2,4DV4I@85009 NA|NA|NA MAG.T12.14_00908 1122138.AQUZ01000074_gene7344 1.2e-68 266.2 Propionibacteriales Bacteria 2IJS1@201174,4DUDM@85009,COG1708@1,COG1708@2 NA|NA|NA S Nucleotidyltransferase domain MAG.T12.14_00909 1416759.AYMR01000011_gene320 1.7e-85 323.2 Actinobacteria Bacteria 2I7P1@201174,COG0457@1,COG0457@2 NA|NA|NA S Domain of unknown function (DUF4037) MAG.T12.14_00910 754252.PFREUD_01970 7.7e-162 577.0 Propionibacteriales Bacteria 2GN3K@201174,4DPZD@85009,COG3177@1,COG3177@2 NA|NA|NA S Fic/DOC family MAG.T12.14_00911 644548.SCNU_00065 6.9e-23 114.4 Gordoniaceae Bacteria 2GMMI@201174,4GD92@85026,COG0582@1,COG0582@2 NA|NA|NA L Belongs to the 'phage' integrase family MAG.T12.14_00912 367299.JOEE01000004_gene1254 1.1e-20 107.5 Intrasporangiaceae Bacteria 2CD8B@1,2II9F@201174,30VJG@2,4FI3H@85021 NA|NA|NA MAG.T12.14_00913 710696.Intca_0674 9.3e-45 186.8 Intrasporangiaceae ko:K03088 ko00000,ko03021 Bacteria 2IRNG@201174,4FH7C@85021,COG1595@1,COG1595@2 NA|NA|NA K Belongs to the sigma-70 factor family MAG.T12.14_00914 1313172.YM304_40470 6.1e-10 71.6 Actinobacteria ko:K11748 ko00000,ko02000 2.A.37.1.2 Bacteria 2DDQ5@1,2HDNV@201174,2ZIVU@2 NA|NA|NA MAG.T12.14_00915 882083.SacmaDRAFT_3092 3.4e-142 511.5 Pseudonocardiales aslB GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0019538,GO:0043170,GO:0044238,GO:0051604,GO:0071704,GO:1901564 ko:K06871 ko00000 Bacteria 2GMTV@201174,4E1AJ@85010,COG0641@1,COG0641@2 NA|NA|NA C Radical SAM superfamily MAG.T12.14_00916 1380356.JNIK01000015_gene2367 4e-299 1033.9 Frankiales 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 Bacteria 2GJ8H@201174,4ETR9@85013,COG3119@1,COG3119@2 NA|NA|NA P Sulfatase MAG.T12.14_00917 1033730.CAHG01000016_gene350 4.8e-81 308.9 Propionibacteriales ko:K03321 ko00000,ko02000 2.A.53.3 Bacteria 2GJCB@201174,4DT31@85009,COG0659@1,COG0659@2 NA|NA|NA P Sulfate permease family MAG.T12.14_00918 1517681.HW45_14665 1e-58 233.0 Vibrionales hpt 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 Bacteria 1QJNX@1224,1THPU@1236,1XX3B@135623,COG0634@1,COG0634@2 NA|NA|NA F Phosphoribosyl transferase domain MAG.T12.14_00923 28444.JODQ01000006_gene351 3.5e-17 95.1 Streptosporangiales ko:K03088 ko00000,ko03021 Bacteria 2IRNG@201174,4EJSS@85012,COG1595@1,COG1595@2 NA|NA|NA K Sigma-70, region 4 MAG.T12.14_00924 298654.FraEuI1c_2160 2e-69 269.2 Frankiales ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GIVW@201174,4ERFD@85013,COG0842@1,COG0842@2 NA|NA|NA V PFAM ABC-2 type transporter MAG.T12.14_00925 208439.AJAP_13005 3.1e-101 375.2 Pseudonocardiales ko:K01990,ko:K18232 ko02010,map02010 M00254,M00634 ko00000,ko00001,ko00002,ko01504,ko02000 3.A.1,3.A.1.105.2 Bacteria 2GIY8@201174,4DXJX@85010,COG1131@1,COG1131@2 NA|NA|NA V Part of the ABC transporter complex DrrAB involved in daunorubicin and doxorubicin resistance. Responsible for energy coupling to the transport system. Binds ATP or GTP MAG.T12.14_00926 500153.JOEK01000003_gene1011 1e-07 62.8 Actinobacteria Bacteria 2GJZC@201174,COG3595@1,COG3595@2 NA|NA|NA S Putative adhesin MAG.T12.14_00927 1125971.ASJB01000074_gene74 2.1e-35 155.6 Pseudonocardiales Bacteria 2IKXB@201174,4E3FU@85010,COG4226@1,COG4226@2 NA|NA|NA S protein encoded in hypervariable junctions of pilus gene clusters MAG.T12.14_00929 1713.JOFV01000003_gene1528 1.9e-129 469.2 Cellulomonadaceae hemD 2.1.1.107,4.2.1.75 ko:K01719,ko:K13542 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165,R03194 RC00003,RC00871,RC01861 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKMM@201174,4F0R3@85016,COG0745@1,COG0745@2,COG1587@1,COG1587@2 NA|NA|NA HK PFAM Uroporphyrinogen III synthase HEM4 MAG.T12.14_00930 1380354.JIAN01000005_gene1238 1.4e-75 289.7 Cellulomonadaceae cysG GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009628,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.13.11.79,1.3.1.76,2.1.1.107,2.1.1.131,3.7.1.12,4.99.1.4 ko:K02302,ko:K02303,ko:K02304,ko:K04719,ko:K13541 ko00740,ko00860,ko01100,ko01110,ko01120,map00740,map00860,map01100,map01110,map01120 M00121 R02864,R03194,R03947,R05180,R05809,R07772,R09083 RC00003,RC00435,RC00871,RC01012,RC01034,RC01293,RC01545,RC02097,RC02413,RC03471 ko00000,ko00001,ko00002,ko01000 iECIAI1_1343.ECIAI1_3507,iECSE_1348.ECSE_3630,iEcE24377_1341.EcE24377A_3838,iJN746.PP_3999,iPC815.YPO0158 Bacteria 2GK3B@201174,4F260@85016,COG0007@1,COG0007@2,COG1648@1,COG1648@2 NA|NA|NA H PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase MAG.T12.14_00931 1385519.N801_03455 8.5e-31 139.8 Intrasporangiaceae nirD GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006091,GO:0008150,GO:0008152,GO:0008942,GO:0009061,GO:0009344,GO:0009987,GO:0015980,GO:0016491,GO:0016661,GO:0032991,GO:0044237,GO:0044424,GO:0044464,GO:0045333,GO:0046857,GO:0055114,GO:0098809 1.7.1.15 ko:K00362,ko:K00363,ko:K05710 ko00360,ko00910,ko01120,ko01220,map00360,map00910,map01120,map01220 M00530,M00545 R00787,R06782,R06783 RC00098,RC00176 br01602,ko00000,ko00001,ko00002,ko01000 iEC55989_1330.EC55989_3772 Bacteria 2IQM4@201174,4FHUA@85021,COG2146@1,COG2146@2 NA|NA|NA P Rieske-like [2Fe-2S] domain MAG.T12.14_00932 1385518.N798_06760 0.0 1272.7 Intrasporangiaceae nirB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006091,GO:0008150,GO:0008152,GO:0008942,GO:0009061,GO:0009344,GO:0009987,GO:0015980,GO:0016491,GO:0016661,GO:0020037,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044464,GO:0045333,GO:0046857,GO:0046906,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0051536,GO:0051540,GO:0055114,GO:0097159,GO:0098809,GO:1901265,GO:1901363 1.7.1.15 ko:K00362 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 iECIAI39_1322.ECIAI39_3849 Bacteria 2GJ3U@201174,4FF81@85021,COG1251@1,COG1251@2 NA|NA|NA C Belongs to the nitrite and sulfite reductase 4Fe-4S domain family MAG.T12.14_00933 935839.JAGJ01000004_gene1928 6e-126 458.0 Promicromonosporaceae nasC 1.7.1.15 ko:K00360,ko:K00362 ko00910,ko01120,map00910,map01120 M00530,M00531 R00787,R00798 RC00176,RC02812 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ3U@201174,4F3YI@85017,COG1251@1,COG1251@2 NA|NA|NA C BFD-like [2Fe-2S] binding domain MAG.T12.14_00934 471853.Bcav_2801 7.7e-294 1016.1 Actinobacteria nasC ko:K00372 ko00910,ko01120,map00910,map01120 M00531 R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 Bacteria 2HC9H@201174,COG3383@1,COG3383@2 NA|NA|NA C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family MAG.T12.14_00935 590998.Celf_1257 1.1e-171 609.8 Cellulomonadaceae narU ko:K02575 ko00910,map00910 M00615 ko00000,ko00001,ko00002,ko02000 2.A.1.8 iNJ661.Rv0267 Bacteria 2GJ1I@201174,4F0H3@85016,COG2223@1,COG2223@2 NA|NA|NA P PFAM major facilitator superfamily MFS_1 MAG.T12.14_00936 390989.JOEG01000004_gene3799 1.9e-84 319.7 Micromonosporales mog 2.10.1.1,2.8.1.12,4.6.1.17 ko:K03635,ko:K03637,ko:K03750 ko00790,ko01100,ko04122,map00790,map01100,map04122 R09395,R09735,R11372 RC02507,RC03425,RC03462 ko00000,ko00001,ko01000 Bacteria 2GP1B@201174,4DBSX@85008,COG0303@1,COG0303@2,COG0521@1,COG0521@2 NA|NA|NA H Probable molybdopterin binding domain MAG.T12.14_00937 465541.ATCJ01000005_gene4299 6.4e-44 184.5 Actinobacteria mobA 2.7.7.77 ko:K03752 ko00790,ko01100,map00790,map01100 R11581 ko00000,ko00001,ko01000 Bacteria 2GJVE@201174,COG0746@1,COG0746@2 NA|NA|NA H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor MAG.T12.14_00938 1121946.AUAX01000006_gene3402 1.9e-43 182.2 Micromonosporales moaC 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 R11372 RC03425 ko00000,ko00001,ko01000 Bacteria 2IHR6@201174,4DDCJ@85008,COG0315@1,COG0315@2,COG0521@1,COG0521@2 NA|NA|NA H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) MAG.T12.14_00939 1120934.KB894410_gene6919 1.3e-67 263.5 Pseudonocardiales moaE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.7.7.80,2.8.1.11,2.8.1.12,4.6.1.17 ko:K03635,ko:K03637,ko:K21147 ko00790,ko01100,ko04122,map00790,map01100,map04122 R07459,R07461,R09395,R11372 RC00043,RC02507,RC03425 ko00000,ko00001,ko01000 Bacteria 2II28@201174,4DZNU@85010,COG0314@1,COG0314@2,COG0521@1,COG0521@2 NA|NA|NA H TIGRFAM molybdenum cofactor synthesis MAG.T12.14_00940 1193181.BN10_1080031 1.3e-116 426.4 Intrasporangiaceae moaA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0030312,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0071944,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.22,4.6.1.17 ko:K03639,ko:K20967 ko00790,ko01100,ko04122,map00790,map01100,map04122 R09394,R11372 RC03420,RC03425 ko00000,ko00001,ko01000 Bacteria 2GN0V@201174,4FFGU@85021,COG2896@1,COG2896@2 NA|NA|NA H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate MAG.T12.14_00941 1869.MB27_37345 3.5e-09 67.4 Micromonosporales moaD 2.8.1.12 ko:K03636,ko:K21142 ko00790,ko01100,ko04122,map00790,map01100,map04122 R09395 RC02507 ko00000,ko00001,ko01000 Bacteria 2IQIT@201174,4DFX3@85008,COG1977@1,COG1977@2 NA|NA|NA H ThiS family MAG.T12.14_00942 1194972.MVAC_29845 4.5e-64 251.5 Mycobacteriaceae modA GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0030288,GO:0030313,GO:0030973,GO:0031975,GO:0040007,GO:0042597,GO:0043167,GO:0043168,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704 ko:K02020 ko02010,map02010 M00189 ko00000,ko00001,ko00002,ko02000 3.A.1.8 Bacteria 234BP@1762,2GMPF@201174,COG0725@1,COG0725@2 NA|NA|NA P ABC transporter, periplasmic molybdate-binding protein MAG.T12.14_00943 446471.Xcel_2809 8.4e-84 317.0 Promicromonosporaceae modB GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 3.6.3.29 ko:K02017,ko:K02018,ko:K15496 ko02010,map02010 M00189,M00423 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.6.5,3.A.1.8 iECO103_1326.ECO103_0752 Bacteria 2GJFB@201174,4F4A9@85017,COG4149@1,COG4149@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component MAG.T12.14_00944 196162.Noca_1067 9.6e-91 340.5 Propionibacteriales modC 2.10.1.1,3.6.3.29,3.6.3.55 ko:K02017,ko:K02018,ko:K03750,ko:K15497 ko00790,ko01100,ko02010,map00790,map01100,map02010 M00189,M00423 R09735,R10531 RC00002,RC03462 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.6.5,3.A.1.8 Bacteria 2H2JF@201174,4DPFC@85009,COG3842@1,COG3842@2 NA|NA|NA P TOBE domain MAG.T12.14_00946 585530.HMPREF0183_0645 0.0 1602.0 Brevibacteriaceae Bacteria 2GJRK@201174,4F8SR@85019,COG0507@1,COG0507@2 NA|NA|NA L Pfam PF08751 MAG.T12.14_00948 585530.HMPREF0183_0642 8.2e-219 766.1 Bacteria tetA ko:K08151,ko:K08153 M00668,M00717 ko00000,ko00002,ko01504,ko02000 2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75,2.A.1.2.8 Bacteria COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily MAG.T12.14_00950 714083.JH370377_gene95 5.2e-119 433.7 Microbacteriaceae Bacteria 2I8S4@201174,4FS6V@85023,COG2197@1,COG2197@2 NA|NA|NA K helix_turn_helix, Lux Regulon MAG.T12.14_00951 585530.HMPREF0183_0640 1.4e-24 119.4 Brevibacteriaceae Bacteria 2HEXF@201174,4F9PJ@85019,COG4585@1,COG4585@2 NA|NA|NA T Histidine kinase MAG.T12.14_00952 1449355.JQNR01000005_gene4462 9.3e-34 151.0 Actinobacteria Bacteria 2GNU5@201174,COG3305@1,COG3305@2 NA|NA|NA S Predicted membrane protein (DUF2127) MAG.T12.14_00954 1206737.BAGF01000150_gene6098 7.9e-227 793.9 Nocardiaceae 3.6.3.8 ko:K01537 ko00000,ko01000 3.A.3.2 Bacteria 2GJJC@201174,4FU7Y@85025,COG0474@1,COG0474@2 NA|NA|NA P PFAM E1-E2 ATPase-associated domain protein, Haloacid dehalogenase domain protein hydrolase, cation transporting ATPase domain protein MAG.T12.14_00955 590998.Celf_1669 2.5e-38 165.6 Cellulomonadaceae pabB 2.6.1.85,2.7.1.48,4.1.3.27 ko:K00876,ko:K01657,ko:K13950 ko00240,ko00400,ko00405,ko00790,ko00983,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00240,map00400,map00405,map00790,map00983,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R00985,R00986,R01548,R01549,R01716,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232 RC00002,RC00010,RC00017,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 Bacteria 2HQC8@201174,4F1E0@85016,COG0572@1,COG0572@2 NA|NA|NA F uridine kinase MAG.T12.14_00956 391037.Sare_2321 3.2e-59 235.3 Micromonosporales Bacteria 2GME7@201174,4D9NY@85008,COG5032@1,COG5032@2 NA|NA|NA BDLTU Phosphatidylinositol MAG.T12.14_00957 253839.SSNG_01507 5.7e-44 184.1 Actinobacteria Bacteria 298YA@1,2GIYI@201174,2ZW25@2 NA|NA|NA S Protein of unknown function (DUF3090) MAG.T12.14_00958 1463845.JOIG01000002_gene2537 2.3e-50 205.7 Actinobacteria 3.1.3.3,3.1.3.73,5.4.2.11 ko:K01834,ko:K02226,ko:K22305 ko00010,ko00260,ko00680,ko00860,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003,M00122 R00582,R01518,R04594,R11173 RC00017,RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 Bacteria 2GK8N@201174,COG0406@1,COG0406@2 NA|NA|NA G phosphoglycerate mutase MAG.T12.14_00959 1961.JOAK01000009_gene6352 2.4e-67 262.7 Actinobacteria corA ko:K03284 ko00000,ko02000 1.A.35.1,1.A.35.3 Bacteria 2GKNZ@201174,COG0598@1,COG0598@2 NA|NA|NA P Magnesium transport protein CorA MAG.T12.14_00960 479433.Caci_4794 6.2e-94 350.9 Actinobacteria Bacteria 2GMNA@201174,COG0667@1,COG0667@2 NA|NA|NA C aldo keto reductase MAG.T12.14_00961 105420.BBPO01000009_gene2256 7.9e-151 540.4 Streptacidiphilus Bacteria 2GKKW@201174,2NHP9@228398,COG0624@1,COG0624@2 NA|NA|NA E Peptidase family M28 MAG.T12.14_00962 1137268.AZXF01000015_gene716 1.4e-63 249.2 Streptosporangiales Bacteria 2GJGZ@201174,4EH75@85012,COG1051@1,COG1051@2 NA|NA|NA F Domain of unknown function (DUF4916) MAG.T12.14_00964 1108045.GORHZ_055_00070 3.5e-58 231.9 Actinobacteria ko:K07052 ko00000 Bacteria 2GREE@201174,COG1266@1,COG1266@2 NA|NA|NA S CAAX protease self-immunity MAG.T12.14_00965 994479.GL877878_gene2219 0.0 1274.2 Pseudonocardiales uvrA2 Bacteria 2GJUV@201174,4DZ3D@85010,COG0178@1,COG0178@2 NA|NA|NA L Excinuclease ATPase subunit MAG.T12.14_00966 33876.JNXY01000009_gene9258 2.1e-24 120.2 Micromonosporales hstK 2.7.1.37,2.7.13.3 ko:K00870,ko:K10819,ko:K11527 ko00000,ko01000,ko01001,ko02022 Bacteria 2IBPU@201174,4DAU6@85008,COG0515@1,COG0515@2,COG2199@1,COG3706@2,COG3899@1,COG3899@2 NA|NA|NA T Domain present in phytochromes and cGMP-specific phosphodiesterases. MAG.T12.14_00967 479433.Caci_6918 7.3e-112 412.5 Actinobacteria Bacteria 2GJN3@201174,COG2319@1,COG2319@2 NA|NA|NA F WD-40 repeat MAG.T12.14_00968 68199.JNZO01000008_gene7675 2.2e-64 252.7 Bacteria Bacteria COG1073@1,COG1073@2 NA|NA|NA S thiolester hydrolase activity MAG.T12.14_00970 1172188.KB911821_gene2084 4.5e-48 198.0 Actinobacteria Bacteria 29VND@1,2I845@201174,33797@2 NA|NA|NA MAG.T12.14_00971 1123024.AUII01000001_gene3046 2.2e-17 95.9 Pseudonocardiales oatA GO:0000271,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016020,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509 ko:K19172 ko00000,ko02048 Bacteria 2GKI5@201174,4DZQE@85010,COG1835@1,COG1835@2,COG2755@1,COG2755@2 NA|NA|NA I Acyltransferase family MAG.T12.14_00973 446469.Sked_28510 6.5e-120 437.6 Actinobacteria ackA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016053,GO:0016999,GO:0017000,GO:0017144,GO:0019413,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.7.2.1,2.7.2.15 ko:K00925,ko:K19697 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1034,iIT341.HP0903m,iNJ661.Rv0409 Bacteria 2GJAW@201174,COG0282@1,COG0282@2 NA|NA|NA C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction MAG.T12.14_00974 1304865.JAGF01000001_gene2008 1.5e-199 703.0 Cellulomonadaceae pta GO:0005575,GO:0005576 2.3.1.8 ko:K13788 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00230,R00921 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ5U@201174,4F0GJ@85016,COG0280@1,COG0280@2,COG0857@1,COG0857@2 NA|NA|NA C belongs to the CobB CobQ family MAG.T12.14_00975 1033730.CAHG01000008_gene3077 4.5e-114 419.1 Actinobacteria 3.2.1.14 ko:K01183 ko00520,ko01100,map00520,map01100 R01206,R02334 RC00467 ko00000,ko00001,ko01000 GH18 Bacteria 2IGIW@201174,COG3325@1,COG3325@2 NA|NA|NA G Belongs to the glycosyl hydrolase 18 family MAG.T12.14_00976 67352.JODS01000020_gene3992 7.1e-70 270.8 Actinobacteria spoU2 2.1.1.185 ko:K03218,ko:K03437 ko00000,ko01000,ko03009,ko03016 Bacteria 2GJ12@201174,COG0566@1,COG0566@2 NA|NA|NA J rRNA methyltransferase MAG.T12.14_00977 1123251.ATWM01000010_gene2980 3.7e-88 331.6 Intrasporangiaceae qmcA Bacteria 2GJ1U@201174,4FFBS@85021,COG0330@1,COG0330@2 NA|NA|NA O prohibitin homologues MAG.T12.14_00978 465541.ATCJ01000005_gene2581 2.2e-27 128.6 Actinobacteria nfeD ko:K07340 ko00000 Bacteria 2IHZU@201174,COG1585@1,COG1585@2 NA|NA|NA OU Membrane protein implicated in regulation of membrane protease activity MAG.T12.14_00980 100226.SCO1348 2.5e-30 138.3 Actinobacteria Bacteria 2CP0Z@1,2IHXV@201174,32SI8@2 NA|NA|NA S Protein of unknown function (DUF3037) MAG.T12.14_00981 675635.Psed_2022 3e-79 302.0 Pseudonocardiales Bacteria 2GKX1@201174,4E1RE@85010,COG1718@1,COG1718@2 NA|NA|NA DT Serine threonine protein kinase involved in cell cycle control MAG.T12.14_00982 1128421.JAGA01000002_gene560 3.9e-22 112.1 unclassified Bacteria 3.5.1.106 ko:K15357 ko00760,ko01120,map00760,map01120 M00622 R09126 RC00323,RC02431 ko00000,ko00001,ko00002,ko01000 Bacteria 2NQB7@2323,COG2267@1,COG2267@2 NA|NA|NA I Alpha/beta hydrolase family MAG.T12.14_00983 1146883.BLASA_4759 1.4e-66 260.0 Frankiales Bacteria 2GKVT@201174,4EWMM@85013,COG0697@1,COG0697@2 NA|NA|NA EG EamA-like transporter family MAG.T12.14_00984 1449976.KALB_791 4.9e-40 172.2 Pseudonocardiales 3.1.1.85 ko:K02170,ko:K06889 ko00780,ko01100,map00780,map01100 M00572 R09725 RC00460,RC00461 ko00000,ko00001,ko00002,ko01000 Bacteria 2GMK3@201174,4E10C@85010,COG1073@1,COG1073@2 NA|NA|NA S Prolyl oligopeptidase family MAG.T12.14_00985 931627.MycrhDRAFT_2049 1.6e-171 609.4 Mycobacteriaceae ko:K03294,ko:K03758 ko00000,ko02000 2.A.3.2 Bacteria 23D1J@1762,2H2J4@201174,COG0531@1,COG0531@2 NA|NA|NA E Amino acid permease MAG.T12.14_00986 1048339.KB913029_gene2939 8.5e-280 969.9 Frankiales GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K09118 ko00000 Bacteria 2GMP3@201174,4ERVJ@85013,COG1615@1,COG1615@2 NA|NA|NA S Uncharacterised protein family (UPF0182) MAG.T12.14_00987 1283299.AUKG01000001_gene3535 2.6e-38 166.0 Rubrobacteria apbE 2.7.1.180 ko:K03734 ko00000,ko01000 Bacteria 2GN6F@201174,4CSHI@84995,COG1477@1,COG1477@2 NA|NA|NA H ApbE family MAG.T12.14_00988 47716.JOFH01000006_gene1658 2.1e-35 155.6 Actinobacteria Bacteria 2DA1Q@1,2GKR3@201174,32TUF@2 NA|NA|NA MAG.T12.14_00989 2002.JOEQ01000007_gene1821 2.5e-68 266.2 Streptosporangiales lon ko:K07177 ko02024,map02024 ko00000,ko00001,ko01002 Bacteria 2GJDD@201174,4EFR5@85012,COG3480@1,COG3480@2 NA|NA|NA T Lon protease (S16) C-terminal proteolytic domain MAG.T12.14_00990 58123.JOFJ01000003_gene2296 7.9e-117 427.6 Streptosporangiales Bacteria 2GJ9K@201174,4EFYY@85012,COG5282@1,COG5282@2 NA|NA|NA S Zincin-like metallopeptidase MAG.T12.14_00991 1394178.AWOO02000039_gene8628 1.4e-30 139.8 Streptosporangiales nudJ ko:K12152 ko00000,ko01000 Bacteria 2GU6D@201174,4EIW9@85012,COG0494@1,COG0494@2 NA|NA|NA L NUDIX domain MAG.T12.14_00992 479433.Caci_7935 7.7e-70 270.8 Actinobacteria 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 Bacteria 2I7QX@201174,COG1024@1,COG1024@2 NA|NA|NA I Belongs to the enoyl-CoA hydratase isomerase family MAG.T12.14_00993 1504319.GM45_1925 1.6e-15 87.8 Actinobacteria Bacteria 2E479@1,2GQXY@201174,32Z35@2 NA|NA|NA MAG.T12.14_00994 1048339.KB913029_gene2928 5.5e-157 560.8 Frankiales Bacteria 2GJQ6@201174,4ES31@85013,COG0661@1,COG0661@2 NA|NA|NA S PFAM ABC-1 domain protein MAG.T12.14_00995 1385521.N803_02695 4e-181 641.7 Intrasporangiaceae uvrD 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 2GKRW@201174,4FFFK@85021,COG0210@1,COG0210@2 NA|NA|NA L DNA helicase MAG.T12.14_00996 436229.JOEH01000016_gene7218 1.7e-57 229.9 Streptacidiphilus nudC 3.6.1.22 ko:K03426 ko00760,ko01100,ko04146,map00760,map01100,map04146 R00103,R03004,R11104 RC00002 ko00000,ko00001,ko01000 Bacteria 2GJZY@201174,2NF9K@228398,COG2816@1,COG2816@2 NA|NA|NA L NADH pyrophosphatase-like rudimentary NUDIX domain MAG.T12.14_00997 1123320.KB889672_gene3701 8.6e-57 227.6 Actinobacteria Bacteria 2GP3V@201174,COG3568@1,COG3568@2 NA|NA|NA L endonuclease exonuclease phosphatase MAG.T12.14_00998 1894.JOER01000030_gene507 1e-207 730.7 Actinobacteria uvrD2 3.6.4.12 ko:K03657,ko:K07465 ko03420,ko03430,map03420,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 2GM2E@201174,COG0210@1,COG0210@2,COG2887@1,COG2887@2 NA|NA|NA L Belongs to the helicase family. UvrD subfamily MAG.T12.14_00999 73044.JNXP01000009_gene2772 1.9e-193 683.3 Actinobacteria uvrD 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 2GJD0@201174,COG0210@1,COG0210@2,COG2887@1,COG2887@2 NA|NA|NA L Belongs to the helicase family. UvrD subfamily MAG.T12.14_01000 28444.JODQ01000008_gene1197 2.3e-140 506.5 Streptosporangiales Bacteria 2GMAV@201174,4EHD3@85012,COG0392@1,COG0392@2 NA|NA|NA I Lysylphosphatidylglycerol synthase TM region MAG.T12.14_01001 1298863.AUEP01000002_gene1395 3.5e-19 102.1 Propionibacteriales Bacteria 29S49@1,2GWCT@201174,30D8R@2,4DVAR@85009 NA|NA|NA S TadE-like protein MAG.T12.14_01002 1298863.AUEP01000002_gene1394 4.6e-88 332.4 Propionibacteriales Bacteria 2IAR7@201174,4DTBY@85009,COG4655@1,COG4655@2 NA|NA|NA S Putative Flp pilus-assembly TadE/G-like MAG.T12.14_01003 1298863.AUEP01000002_gene1395 4.4e-19 101.7 Propionibacteriales Bacteria 29S49@1,2GWCT@201174,30D8R@2,4DVAR@85009 NA|NA|NA S TadE-like protein MAG.T12.14_01004 196162.Noca_3114 1.2e-33 150.2 Propionibacteriales cpaB ko:K02279 ko00000,ko02035,ko02044 Bacteria 2INHS@201174,4DSV2@85009,COG3745@1,COG3745@2 NA|NA|NA U Flp pilus assembly protein RcpC/CpaB MAG.T12.14_01005 1380370.JIBA01000003_gene2731 1.5e-78 300.1 Intrasporangiaceae flpE ko:K02282 ko00000,ko02035,ko02044 Bacteria 2GNHI@201174,4FG1C@85021,COG4963@1,COG4963@2 NA|NA|NA D chromosome partitioning MAG.T12.14_01009 313589.JNB_03230 6.4e-104 384.4 Intrasporangiaceae serB GO:0003674,GO:0003824,GO:0004647,GO:0004721,GO:0004722,GO:0005488,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016597,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0031406,GO:0036094,GO:0036211,GO:0040007,GO:0042578,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564 3.1.3.3 ko:K01079 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R00582 RC00017 ko00000,ko00001,ko00002,ko01000,ko01009 iNJ661.Rv3042c Bacteria 2GJDH@201174,4FFIF@85021,COG0560@1,COG0560@2,COG3830@1,COG3830@2 NA|NA|NA E phosphoserine phosphatase MAG.T12.14_01010 43759.JNWK01000070_gene4557 2.7e-35 155.2 Actinobacteria sixA ko:K08296 ko00000,ko01000 Bacteria 2GJ0I@201174,COG2062@1,COG2062@2 NA|NA|NA T phosphohistidine phosphatase, SixA MAG.T12.14_01011 479435.Kfla_3707 8.1e-70 270.8 Propionibacteriales cphB GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0042802,GO:0042803,GO:0043170,GO:0044238,GO:0046983,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.15.6 ko:K13282 R09722 RC00064,RC00141 ko00000,ko01000,ko01002 iJN678.slr2001 Bacteria 2I93U@201174,4DP1Z@85009,COG4242@1,COG4242@2 NA|NA|NA PQ Peptidase family S51 MAG.T12.14_01012 1172188.KB911823_gene478 0.0 1226.8 Intrasporangiaceae cphA 6.3.2.13,6.3.2.29,6.3.2.30 ko:K01928,ko:K03802 ko00300,ko00550,map00300,map00550 R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 Bacteria 2GN0U@201174,4FESF@85021,COG0189@1,COG0189@2,COG0769@1,COG0769@2 NA|NA|NA HJM Belongs to the MurCDEF family MAG.T12.14_01013 1298863.AUEP01000005_gene2400 1.6e-105 390.2 Propionibacteriales murE 6.3.2.13,6.3.2.29,6.3.2.30 ko:K01928,ko:K03802 ko00300,ko00550,map00300,map00550 R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 Bacteria 2GME3@201174,4DPYG@85009,COG0769@1,COG0769@2 NA|NA|NA M Mur ligase middle domain MAG.T12.14_01014 645465.ACUR01000099_gene2676 8e-168 597.0 Actinobacteria tldD ko:K03568 ko00000,ko01002 Bacteria 2GJ4E@201174,COG0312@1,COG0312@2 NA|NA|NA S Modulator of DNA gyrase MAG.T12.14_01015 67281.JNZZ01000018_gene544 2.5e-104 386.0 Streptomyces griseus group tldD3 Bacteria 2GZPS@201174,419X8@629295,COG0312@1,COG0312@2 NA|NA|NA S Putative modulator of DNA gyrase MAG.T12.14_01016 935866.JAER01000002_gene1853 7.9e-26 122.5 Propionibacteriales ko:K09165 ko00000 Bacteria 2IQ6Z@201174,4DS6C@85009,COG3360@1,COG3360@2 NA|NA|NA S Dodecin MAG.T12.14_01017 196162.Noca_2569 1.8e-07 62.4 Propionibacteriales Bacteria 2EGIC@1,2I19N@201174,33AAH@2,4DSK8@85009 NA|NA|NA S Protein of unknown function (DUF3099) MAG.T12.14_01018 395965.Msil_2988 2.8e-84 318.9 Beijerinckiaceae 1.3.98.1 ko:K00226 ko00240,ko01100,map00240,map01100 M00051 R01867 RC00051 ko00000,ko00001,ko00002,ko01000 Bacteria 1MXER@1224,2V9AU@28211,3NBTI@45404,COG0167@1,COG0167@2 NA|NA|NA F Dihydroorotate dehydrogenase MAG.T12.14_01019 1184607.AUCHE_05_04270 0.0 1384.4 Actinobacteria nifJ GO:0003674,GO:0003824,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016491,GO:0016625,GO:0016903,GO:0043873,GO:0050896,GO:0055114 1.18.1.2,1.19.1.1,1.2.7.1,1.2.7.3,1.3.7.1 ko:K00176,ko:K00528,ko:K03737,ko:K20449 ko00010,ko00020,ko00620,ko00650,ko00720,ko00760,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map00760,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00307,M00620 R01196,R01197,R03164,R10159,R10866 RC00004,RC02422,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 iJN678.nifJ,iLF82_1304.LF82_2789,iNRG857_1313.NRG857_06920 Bacteria 2I995@201174,COG0674@1,COG0674@2,COG1013@1,COG1013@2,COG1014@1,COG1014@2,COG1149@1,COG1149@2 NA|NA|NA C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin MAG.T12.14_01020 1304865.JAGF01000001_gene2477 0.0 2345.1 Actinobacteria nifJ 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2I995@201174,COG0674@1,COG0674@2,COG1013@1,COG1013@2,COG1014@1,COG1014@2,COG1144@1,COG1144@2,COG1145@1,COG1145@2 NA|NA|NA C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin MAG.T12.14_01021 1304865.JAGF01000001_gene2476 0.0 1536.2 Cellulomonadaceae gltA 1.18.1.2,1.19.1.1,1.4.1.13,1.4.1.14 ko:K00266,ko:K00528,ko:K02823 ko00240,ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00240,map00250,map00910,map01100,map01110,map01120,map01130,map01230 R00093,R00114,R00248,R10159 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 Bacteria 2GJ0A@201174,4F0FS@85016,COG0493@1,COG0493@2,COG0543@1,COG0543@2 NA|NA|NA E TIGRFAM glutamate synthase, NADH NADPH, small subunit MAG.T12.14_01022 1306174.JODP01000013_gene7557 1.7e-50 205.7 Actinobacteria hit GO:0003674,GO:0003824,GO:0003877,GO:0004551,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008796,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009987,GO:0015959,GO:0015961,GO:0015965,GO:0015967,GO:0016020,GO:0016462,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0070566,GO:0071704,GO:0071944,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 2.7.7.53 ko:K19710 ko00230,map00230 R00126,R01618 RC00002,RC02753,RC02795 ko00000,ko00001,ko01000 Bacteria 2GJT5@201174,COG0537@1,COG0537@2 NA|NA|NA FG Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases MAG.T12.14_01023 1077972.ARGLB_080_00570 1.3e-07 64.7 Micrococcaceae Bacteria 1W96H@1268,2GXWA@201174,COG4932@1,COG4932@2 NA|NA|NA M Belongs to the peptidase S8 family MAG.T12.14_01024 1120949.KB903314_gene339 1.1e-150 539.7 Actinobacteria ybdK GO:0003674,GO:0003824,GO:0016874,GO:0016879 ko:K06048 ko00000,ko01000 Bacteria 2GKAA@201174,COG2170@1,COG2170@2 NA|NA|NA S ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity MAG.T12.14_01025 1122138.AQUZ01000001_gene1498 6.2e-277 959.9 Propionibacteriales thrS GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 2GKTC@201174,4DN38@85009,COG0441@1,COG0441@2 NA|NA|NA J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) MAG.T12.14_01026 1108045.GORHZ_135_00210 1.1e-121 443.4 Gordoniaceae acrA1_1 Bacteria 2I2PV@201174,4GAW1@85026,COG3320@1,COG3320@2 NA|NA|NA M Male sterility protein MAG.T12.14_01027 196162.Noca_1668 8.8e-271 939.5 Actinobacteria GO:0000041,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0006826,GO:0008150,GO:0008152,GO:0008823,GO:0015677,GO:0015682,GO:0016020,GO:0016021,GO:0016491,GO:0016722,GO:0016723,GO:0030001,GO:0031224,GO:0031226,GO:0033216,GO:0034220,GO:0034755,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0052851,GO:0055085,GO:0055114,GO:0071944,GO:0072512,GO:0097286,GO:0098655,GO:0098657,GO:0098659,GO:0098660,GO:0098662,GO:0098706,GO:0098711,GO:0098739,GO:0099587 1.2.1.80 ko:K14330 ko00000,ko01000 Bacteria 2IEVX@201174,COG5322@1,COG5322@2 NA|NA|NA S oxidoreductase activity MAG.T12.14_01028 1386089.N865_13575 9.6e-39 166.8 Intrasporangiaceae Bacteria 2EH65@1,2I75W@201174,33AY1@2,4FH3V@85021 NA|NA|NA S Domain of unknown function (DUF1876) MAG.T12.14_01031 471852.Tcur_2049 8.3e-23 114.0 Streptosporangiales Bacteria 2EQY7@1,2I34U@201174,33IHV@2,4ER5N@85012 NA|NA|NA S Putative transmembrane protein (PGPGW) MAG.T12.14_01032 67257.JODR01000017_gene4448 2.5e-26 125.2 Actinobacteria ssgB GO:0000003,GO:0000910,GO:0005575,GO:0005618,GO:0005623,GO:0007049,GO:0008150,GO:0009653,GO:0009987,GO:0010564,GO:0010927,GO:0016043,GO:0019954,GO:0022402,GO:0022607,GO:0030154,GO:0030312,GO:0030428,GO:0030435,GO:0030436,GO:0030447,GO:0030448,GO:0031160,GO:0032465,GO:0032467,GO:0032502,GO:0032506,GO:0032989,GO:0032991,GO:0040007,GO:0042244,GO:0042546,GO:0043934,GO:0043936,GO:0044085,GO:0044457,GO:0044464,GO:0045229,GO:0045787,GO:0048518,GO:0048522,GO:0048646,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0051301,GO:0051302,GO:0051726,GO:0051781,GO:0065007,GO:0070590,GO:0070726,GO:0071554,GO:0071555,GO:0071840,GO:0071944,GO:0090068,GO:0090529,GO:1903664,GO:1903666,GO:1990586,GO:2000241,GO:2000243,GO:2000244,GO:2000246 Bacteria 2IFE3@201174,32RFA@2,arCOG03175@1 NA|NA|NA S sporulation resulting in formation of a cellular spore MAG.T12.14_01033 1003195.SCAT_5281 5.2e-71 274.6 Actinobacteria 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 2GN5Z@201174,COG0115@1,COG0115@2 NA|NA|NA EH Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase MAG.T12.14_01034 1172180.KB911785_gene337 2e-122 445.7 Actinobacteria pabB 2.6.1.85,4.1.3.27,4.1.3.38 ko:K01665,ko:K03342,ko:K13503,ko:K13950 ko00400,ko00790,ko01100,ko01110,ko01130,ko01230,map00400,map00790,map01100,map01110,map01130,map01230 M00023 R00985,R00986,R01716,R05553 RC00010,RC01418,RC01843,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 2GN7D@201174,COG0147@1,COG0147@2 NA|NA|NA EH PFAM chorismate MAG.T12.14_01035 66429.JOFL01000016_gene64 7.2e-11 72.8 Actinobacteria Bacteria 2IG7Y@201174,COG2197@1,COG2197@2 NA|NA|NA K helix_turn_helix, Lux Regulon MAG.T12.14_01037 743718.Isova_2354 2.9e-44 185.3 Promicromonosporaceae hpf GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113 ko:K05808 ko00000,ko03009 Bacteria 2GMYF@201174,4F3CD@85017,COG1544@1,COG1544@2 NA|NA|NA J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase MAG.T12.14_01038 1211815.CBYP010000043_gene3449 4e-29 135.2 Frankiales ctsW ko:K02242 M00429 ko00000,ko00002,ko02044 Bacteria 2I9PA@201174,4ET02@85013,COG1040@1,COG1040@2 NA|NA|NA S phosphoribosyltransferase MAG.T12.14_01039 931627.MycrhDRAFT_0079 1.1e-32 147.9 Mycobacteriaceae CP_0034 ko:K02417,ko:K02519 ko02030,ko02040,map02030,map02040 ko00000,ko00001,ko02035,ko02044,ko03012,ko03029 3.A.6.2,3.A.6.3 Bacteria 2330W@1762,2GKJ7@201174,COG5180@1,COG5180@2 NA|NA|NA A pathogenesis MAG.T12.14_01040 1089545.KB913037_gene5605 3.1e-38 165.2 Pseudonocardiales Bacteria 2CT9V@1,2GKR6@201174,32SSX@2,4E4EE@85010 NA|NA|NA S Domain of unknown function (DUF4129) MAG.T12.14_01041 1123320.KB889749_gene4532 1.2e-54 220.7 Actinobacteria GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 29B69@1,2GKQW@201174,2ZY4N@2 NA|NA|NA MAG.T12.14_01042 1449346.JQMO01000003_gene5361 2.8e-134 485.0 Kitasatospora moxR2 ko:K03924 ko00000,ko01000 Bacteria 2GK07@201174,2M108@2063,COG0714@1,COG0714@2 NA|NA|NA S ATPase family associated with various cellular activities (AAA) MAG.T12.14_01043 208444.JNYY01000029_gene1055 1.8e-115 422.9 Pseudonocardiales Bacteria 2GK9A@201174,4DXK9@85010,COG1721@1,COG1721@2 NA|NA|NA S Protein of unknown function DUF58 MAG.T12.14_01044 1122611.KB903946_gene708 1.8e-96 359.4 Streptosporangiales ko:K06384 ko00000 Bacteria 2GJTG@201174,4EH4Y@85012,COG1300@1,COG1300@2 NA|NA|NA S Stage II sporulation protein M MAG.T12.14_01045 1125971.ASJB01000080_gene7656 1.3e-51 210.3 Pseudonocardiales Bacteria 2H4MP@201174,4E2SC@85010,COG1714@1,COG1714@2 NA|NA|NA S RDD family MAG.T12.14_01046 269800.Tfu_2505 6e-226 790.0 Streptosporangiales ahcY GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 Bacteria 2GK2Q@201174,4EIAX@85012,COG0499@1,COG0499@2 NA|NA|NA H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine MAG.T12.14_01047 134676.ACPL_1062 1.7e-91 342.8 Micromonosporales cat Bacteria 2GKSG@201174,4DAPD@85008,COG0053@1,COG0053@2 NA|NA|NA P cation diffusion facilitator family transporter MAG.T12.14_01048 298654.FraEuI1c_6060 2.8e-13 80.9 Frankiales ycaR GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.7.1.130 ko:K00912,ko:K09791 ko00540,ko01100,map00540,map01100 M00060 R04657 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 Bacteria 2HUT6@201174,4ETHY@85013,COG2835@1,COG2835@2 NA|NA|NA S Trm112p-like protein MAG.T12.14_01049 471852.Tcur_4063 2e-170 605.5 Streptosporangiales manB GO:0003674,GO:0003824,GO:0004615,GO:0005975,GO:0008150,GO:0008152,GO:0016853,GO:0016866,GO:0016868,GO:0044238,GO:0071704 5.4.2.2,5.4.2.8 ko:K01840,ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 iECS88_1305.ECS88_2145,iECUMN_1333.ECUMN_2384,iUTI89_1310.UTI89_C2321 Bacteria 2GJQA@201174,4EGWS@85012,COG1109@1,COG1109@2 NA|NA|NA G Phosphoglucomutase/phosphomannomutase, C-terminal domain MAG.T12.14_01050 1380346.JNIH01000014_gene897 1.3e-39 169.1 Actinobacteria Bacteria 2C7XW@1,2IQ5R@201174,32RR4@2 NA|NA|NA S Protein of unknown function (DUF3499) MAG.T12.14_01051 1120950.KB892759_gene6287 4.4e-33 149.4 Propionibacteriales dedD ko:K02520,ko:K03749,ko:K06204,ko:K16291 ko02026,map02026 ko00000,ko00001,ko01002,ko01011,ko03000,ko03009,ko03012,ko03021,ko03029 Bacteria 2HC8A@201174,4DRQT@85009,COG3147@1,COG3147@2 NA|NA|NA S Non-essential cell division protein that could be required for efficient cell constriction MAG.T12.14_01052 1463864.JOGO01000058_gene3814 5.9e-90 339.3 Actinobacteria Bacteria 2GIUN@201174,COG1216@1,COG1216@2 NA|NA|NA M PFAM Glycosyl transferase family 2 MAG.T12.14_01053 1122622.ATWJ01000015_gene620 4e-32 143.7 Intrasporangiaceae whiB2 ko:K18955 ko00000,ko03000 Bacteria 2CC1Y@1,2IQ4Q@201174,32RUK@2,4FHAS@85021 NA|NA|NA K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA MAG.T12.14_01055 1449355.JQNR01000005_gene2189 1.7e-67 263.1 Actinobacteria 3.2.2.21 ko:K01247 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 2GP69@201174,COG0122@1,COG0122@2 NA|NA|NA L 3-methyladenine DNA glycosylase MAG.T12.14_01056 1079986.JH164840_gene4710 2e-117 429.1 Actinobacteria manC 2.7.7.13,5.4.2.8 ko:K00966,ko:K16881 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114,M00361,M00362 R00885,R01818 RC00002,RC00408 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKTE@201174,COG1208@1,COG1208@2 NA|NA|NA JM Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B gamma epsilon subunits MAG.T12.14_01058 1123320.KB889719_gene7426 7.6e-14 83.6 Actinobacteria Bacteria 2GIX4@201174,COG0318@1,COG0318@2 NA|NA|NA IQ COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases MAG.T12.14_01059 1306174.JODP01000001_gene4657 1.6e-60 241.5 Actinobacteria Bacteria 2GNDB@201174,COG4102@1,COG4102@2,COG5479@1,COG5479@2 NA|NA|NA M N-acetylmuramoyl-L-alanine amidase MAG.T12.14_01060 266940.Krad_0030 1.6e-74 287.0 Actinobacteria Bacteria 2GJM3@201174,COG1316@1,COG1316@2 NA|NA|NA K cell envelope-related transcriptional attenuator MAG.T12.14_01061 1348663.KCH_29210 1.2e-98 366.3 Kitasatospora 2.8.3.5 ko:K01028 ko00072,ko00280,ko00650,map00072,map00280,map00650 R00410 RC00014 ko00000,ko00001,ko01000 Bacteria 2GK61@201174,2M482@2063,COG1788@1,COG1788@2 NA|NA|NA I Coenzyme A transferase MAG.T12.14_01062 1996.JOFO01000004_gene3448 3.3e-91 341.3 Streptosporangiales scoB 2.8.3.5 ko:K01029 ko00072,ko00280,ko00650,map00072,map00280,map00650 R00410 RC00014 ko00000,ko00001,ko01000 Bacteria 2GKV9@201174,4EI8M@85012,COG2057@1,COG2057@2 NA|NA|NA I Coenzyme A transferase MAG.T12.14_01063 110663.KI911558_gene1353 6.7e-10 70.9 Synechococcus ste14 Bacteria 1G67D@1117,1H0KJ@1129,COG2020@1,COG2020@2 NA|NA|NA O Isoprenylcysteine carboxyl methyltransferase (ICMT) family MAG.T12.14_01064 909613.UO65_5851 4.1e-96 358.6 Actinobacteria Bacteria 2H6EP@201174,COG1887@1,COG1887@2 NA|NA|NA M Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC MAG.T12.14_01065 935839.JAGJ01000002_gene821 2e-78 298.9 Actinobacteria phnW 2.6.1.37,2.7.7.74,2.7.8.12 ko:K03430,ko:K07281,ko:K09809 ko00440,ko00562,ko01100,ko01120,map00440,map00562,map01100,map01120 R04152,R09669 RC00002,RC00008,RC00062 ko00000,ko00001,ko01000,ko01007 Bacteria 2GN1Y@201174,COG1213@1,COG1213@2 NA|NA|NA M transferase MAG.T12.14_01066 1120959.ATXF01000010_gene75 5.4e-100 370.9 Microbacteriaceae GO:0003674,GO:0003824,GO:0016740,GO:0016757 ko:K07011 ko00000 Bacteria 2GK2D@201174,4FMHT@85023,COG1216@1,COG1216@2 NA|NA|NA S Glycosyl transferase family 2 MAG.T12.14_01067 1348338.ADILRU_1958 2.7e-74 285.4 Microbacteriaceae Bacteria 2GN3C@201174,4FKEI@85023,COG0558@1,COG0558@2 NA|NA|NA I CDP-alcohol phosphatidyltransferase MAG.T12.14_01068 1123320.KB889669_gene3225 2.6e-56 226.9 Actinobacteria Bacteria 2GKG1@201174,COG0558@1,COG0558@2 NA|NA|NA I Belongs to the CDP-alcohol phosphatidyltransferase class-I family MAG.T12.14_01069 1394178.AWOO02000005_gene3524 2.1e-111 409.1 Streptosporangiales exoA Bacteria 2GMWF@201174,4EHSA@85012,COG1215@1,COG1215@2 NA|NA|NA M Glycosyl transferase family 21 MAG.T12.14_01071 1449347.JQLN01000007_gene1076 7.6e-138 497.3 Kitasatospora ypeA ko:K13525 ko04141,ko05134,map04141,map05134 M00400,M00403 ko00000,ko00001,ko00002,ko03019,ko04131,ko04147 3.A.16.1 Bacteria 2GJ07@201174,2M4MQ@2063,COG0454@1,COG0456@2,COG0464@1,COG0464@2 NA|NA|NA KO ATPase family associated with various cellular activities (AAA) MAG.T12.14_01074 1043205.AFYF01000087_gene1224 5.5e-91 342.4 Intrasporangiaceae 2.7.8.12 ko:K09809 ko00000,ko01000 Bacteria 2GM0T@201174,4FISM@85021,COG1887@1,COG1887@2 NA|NA|NA M CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase MAG.T12.14_01075 216594.MMAR_1906 6.7e-19 99.8 Mycobacteriaceae Bacteria 23AN3@1762,2IQKN@201174,COG5552@1,COG5552@2 NA|NA|NA S Uncharacterized conserved protein (DUF2277) MAG.T12.14_01076 44060.JODL01000024_gene339 1.5e-40 173.3 Actinobacteria lamB ko:K07160 ko00000 Bacteria 2GJA1@201174,COG1540@1,COG1540@2 NA|NA|NA S Belongs to the UPF0271 (lamB) family MAG.T12.14_01077 1151126.AQYI01000006_gene2850 2.8e-34 152.1 Microbacteriaceae ybgK Bacteria 2GITH@201174,4FMAJ@85023,COG1984@1,COG1984@2,COG2049@1,COG2049@2 NA|NA|NA E Allophanate hydrolase subunit 2 MAG.T12.14_01078 1122182.KB903814_gene3437 1.3e-29 137.1 Micromonosporales kipA Bacteria 2GITH@201174,4DBQR@85008,COG1984@1,COG1984@2 NA|NA|NA E Allophanate hydrolase subunit 2 MAG.T12.14_01079 1229780.BN381_800004 1.5e-06 60.5 Actinobacteria ko:K11748 ko00000,ko02000 2.A.37.1.2 Bacteria 2DDQ5@1,2HDNV@201174,2ZIVU@2 NA|NA|NA MAG.T12.14_01080 1386089.N865_21420 5.3e-21 107.1 Intrasporangiaceae Bacteria 2AY0M@1,2I859@201174,32Z2S@2,4FH02@85021 NA|NA|NA S Phospholipase_D-nuclease N-terminal MAG.T12.14_01081 1298863.AUEP01000012_gene3662 2.7e-36 158.7 Propionibacteriales ko:K21429 ko00000,ko01002 Bacteria 2GKWI@201174,4DUPV@85009,COG4894@1,COG4894@2 NA|NA|NA S LURP-one-related MAG.T12.14_01082 1380390.JIAT01000011_gene2324 1.4e-22 114.0 Rubrobacteria Bacteria 2GK0H@201174,4CTG0@84995,COG0628@1,COG0628@2 NA|NA|NA S AI-2E family transporter MAG.T12.14_01083 1386089.N865_21145 9.9e-68 263.8 Actinobacteria GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016874,GO:0016879,GO:0016881,GO:0018169,GO:0018410,GO:0019538,GO:0031668,GO:0033554,GO:0036211,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0070739,GO:0071496,GO:0071704,GO:0140096,GO:1901564 ko:K03281,ko:K03455,ko:K03499,ko:K05571,ko:K05844,ko:K07402,ko:K11105 ko00000,ko01000,ko02000,ko03009 2.A.36.6,2.A.37,2.A.38.1,2.A.38.4,2.A.49,2.A.63.1,2.A.63.2 Bacteria 2I2I2@201174,COG0569@1,COG0569@2 NA|NA|NA P Ion transport protein MAG.T12.14_01085 2002.JOEQ01000025_gene232 8e-07 60.1 Streptosporangiales ko:K06975 ko00000 Bacteria 2GQNP@201174,4EKDK@85012,COG2388@1,COG2388@2 NA|NA|NA S GCN5-related N-acetyl-transferase MAG.T12.14_01086 1380370.JIBA01000012_gene3816 6e-67 261.2 Intrasporangiaceae ko:K04088,ko:K14393 M00742 ko00000,ko00002,ko01000,ko02000 2.A.21.7 Bacteria 2IE4A@201174,4FIM4@85021,COG0330@1,COG0330@2 NA|NA|NA O SPFH domain / Band 7 family MAG.T12.14_01087 1283283.ATXA01000008_gene3123 2.8e-45 188.7 Frankiales Bacteria 2CA7I@1,2IFD8@201174,2ZTHS@2,4EV1F@85013 NA|NA|NA MAG.T12.14_01088 1120948.KB903217_gene1344 1.6e-19 103.6 Actinobacteria Bacteria 2IPMP@201174,COG3064@1,COG3064@2,COG4733@1,COG4733@2 NA|NA|NA M calcium- and calmodulin-responsive adenylate cyclase activity MAG.T12.14_01091 235985.BBPN01000004_gene3114 1.3e-32 147.1 Streptacidiphilus apbE 2.7.1.180 ko:K03734 ko00000,ko01000 Bacteria 2H74Y@201174,2NF9E@228398,COG1477@1,COG1477@2 NA|NA|NA H ApbE family MAG.T12.14_01092 1206731.BAGB01000163_gene7753 3.8e-19 101.7 Nocardiaceae Bacteria 2GQH2@201174,4G1BH@85025,COG4097@1,COG4097@2 NA|NA|NA P Ferric reductase like transmembrane component MAG.T12.14_01093 66429.JOFL01000001_gene4522 9.2e-50 204.5 Actinobacteria nuoF2 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2GNN9@201174,COG1894@1,COG1894@2 NA|NA|NA C NADH ubiquinone oxidoreductase NADH-binding (51 kD) subunit MAG.T12.14_01094 66377.JOBH01000010_gene6019 6.8e-66 257.3 Actinobacteria Bacteria 2GMVN@201174,COG0745@1,COG0745@2 NA|NA|NA T response regulator MAG.T12.14_01095 196162.Noca_4423 1.7e-49 203.8 Propionibacteriales 2.7.13.3 ko:K02484,ko:K07653,ko:K07654 ko02020,map02020 M00460,M00461 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 2I3U8@201174,4DU9B@85009,COG5002@1,COG5002@2 NA|NA|NA T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain MAG.T12.14_01096 1240349.ANGC01000055_gene4012 2.7e-146 525.8 Nocardiaceae yciQ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 2GNW7@201174,4G3G3@85025,COG4907@1,COG4907@2 NA|NA|NA S Predicted membrane protein (DUF2207) MAG.T12.14_01097 110319.CF8_0638 1.6e-57 229.2 Actinobacteria lemA ko:K03744 ko00000 Bacteria 2GPS4@201174,COG1704@1,COG1704@2 NA|NA|NA J LemA family MAG.T12.14_01098 1172188.KB911823_gene665 2.8e-84 319.3 Intrasporangiaceae Bacteria 2I37Q@201174,4FFGA@85021,COG0025@1,COG0025@2 NA|NA|NA P Sodium/hydrogen exchanger family MAG.T12.14_01099 2074.JNYD01000017_gene4333 6.5e-74 284.3 Pseudonocardiales ku GO:0000726,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006303,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050790,GO:0050896,GO:0051340,GO:0051351,GO:0051716,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 ko:K10979 ko03450,map03450 ko00000,ko00001,ko03400 Bacteria 2GJMU@201174,4E10U@85010,COG1273@1,COG1273@2 NA|NA|NA L With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD MAG.T12.14_01100 349521.HCH_05422 2.6e-25 122.1 Oceanospirillales FolA Bacteria 1RH02@1224,1S2UN@1236,1XKZU@135619,COG0262@1,COG0262@2 NA|NA|NA H RibD C-terminal domain MAG.T12.14_01101 263358.VAB18032_25150 3.1e-100 372.1 Micromonosporales Bacteria 2GK0T@201174,4DCHZ@85008,COG3214@1,COG3214@2 NA|NA|NA S Winged helix DNA-binding domain MAG.T12.14_01102 446465.Bfae_27310 2.2e-85 322.8 Dermabacteraceae sbcD ko:K03547 ko00000,ko03400 Bacteria 2GK9R@201174,4FBAD@85020,COG0420@1,COG0420@2 NA|NA|NA L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity MAG.T12.14_01103 1246448.ANAZ01000004_gene4671 2.9e-105 390.2 Streptosporangiales sbcC GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006260,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360,GO:1901576 ko:K03546 ko00000,ko03400 Bacteria 2GKYR@201174,4EG84@85012,COG0419@1,COG0419@2 NA|NA|NA L AAA domain MAG.T12.14_01104 1211815.CBYP010000051_gene667 2.2e-97 362.8 Frankiales pdhC 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GM0D@201174,4ERC0@85013,COG0508@1,COG0508@2 NA|NA|NA C of components of various dehydrogenase complexes MAG.T12.14_01105 469371.Tbis_3331 6.3e-126 457.2 Pseudonocardiales pdhB GO:0003674,GO:0005488,GO:0005515,GO:0140030,GO:0140032 1.2.4.1 ko:K00162,ko:K21417 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS05355,iYO844.BSU14590 Bacteria 2GKFE@201174,4E0CR@85010,COG0022@1,COG0022@2 NA|NA|NA C Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase component beta subunit MAG.T12.14_01106 105425.BBPL01000021_gene769 8e-138 496.9 Streptacidiphilus pdhA 1.2.4.1 ko:K00161 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GK3W@201174,2NFED@228398,COG1071@1,COG1071@2 NA|NA|NA C Dehydrogenase E1 component MAG.T12.14_01107 105420.BBPO01000043_gene3657 8.1e-77 293.9 Streptacidiphilus ko:K07052 ko00000 Bacteria 2GK11@201174,2NHZA@228398,COG1266@1,COG1266@2 NA|NA|NA S CAAX protease self-immunity MAG.T12.14_01108 1089545.KB913037_gene6123 5.8e-95 354.8 Pseudonocardiales GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0040007,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.4.1.11,2.4.1.18 ko:K16149,ko:K16150 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R00292,R02110 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 GH57,GT4 Bacteria 2I2EE@201174,4DZ70@85010,COG0297@1,COG0297@2 NA|NA|NA G Glycosyl transferases group 1 MAG.T12.14_01109 1463820.JOGW01000006_gene6872 3.5e-11 73.2 Actinobacteria rpmH GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02914 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GQFY@201174,COG0230@1,COG0230@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL34 family MAG.T12.14_01110 888439.HMPREF9240_01622 6.9e-24 116.7 Actinobacteria yidD ko:K08998 ko00000 Bacteria 2GQZG@201174,4D6B8@85005,COG0759@1,COG0759@2 NA|NA|NA S Could be involved in insertion of integral membrane proteins into the membrane MAG.T12.14_01111 1504319.GM45_6245 3e-88 332.0 unclassified Actinobacteria (class) yidC ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 Bacteria 2GJBU@201174,3UWKK@52018,COG0706@1,COG0706@2 NA|NA|NA U 60Kd inner membrane protein MAG.T12.14_01112 1157637.KB892093_gene6652 7.8e-50 203.4 Actinobacteria jag ko:K06346,ko:K09749 ko00000 Bacteria 2GPZK@201174,COG1847@1,COG1847@2 NA|NA|NA S R3H domain protein MAG.T12.14_01113 585531.HMPREF0063_10409 1.3e-50 206.5 Propionibacteriales rsmG GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 ko:K03501 ko00000,ko01000,ko03009,ko03036 Bacteria 2GM9Z@201174,4DQN8@85009,COG0357@1,COG0357@2 NA|NA|NA M Specifically methylates the N7 position of a guanine in 16S rRNA MAG.T12.14_01114 1121385.AQXW01000004_gene2687 8.8e-89 333.6 Dermacoccaceae parB GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005694,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0060187,GO:0071944 ko:K03497 ko00000,ko03000,ko03036,ko04812 Bacteria 1ZVBH@145357,2GNRN@201174,COG1475@1,COG1475@2 NA|NA|NA K Belongs to the ParB family MAG.T12.14_01115 443218.AS9A_0015 1.1e-06 60.8 Actinobacteria Bacteria 291QM@1,2H0PF@201174,2ZPAP@2 NA|NA|NA MAG.T12.14_01116 471852.Tcur_4976 8.6e-96 357.1 Streptosporangiales ddl 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 Bacteria 2GRWM@201174,4EFUD@85012,COG1181@1,COG1181@2 NA|NA|NA M Belongs to the D-alanine--D-alanine ligase family MAG.T12.14_01117 1454010.JEOE01000029_gene3028 5.9e-151 540.8 Cellulomonadaceae avtA ko:K05825 ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210 R01939 RC00006 ko00000,ko00001,ko01000 Bacteria 2GITW@201174,4F2B4@85016,COG1167@1,COG1167@2 NA|NA|NA EK Aminotransferase class I and II MAG.T12.14_01119 1032480.MLP_35050 8.1e-15 89.4 Propionibacteriales Bacteria 2IBN6@201174,4DP5E@85009,COG1502@1,COG1502@2 NA|NA|NA I PLD-like domain MAG.T12.14_01120 1048339.KB913029_gene1659 6.4e-90 337.8 Frankiales cwlM GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 3.2.1.17,3.5.1.28 ko:K01185,ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 Bacteria 2GPA9@201174,4ERBQ@85013,COG0860@1,COG0860@2,COG3409@1,COG3409@2 NA|NA|NA M Cell wall hydrolase autolysin MAG.T12.14_01121 67315.JOBD01000019_gene7672 2.1e-38 164.9 Actinobacteria trxA GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.8.1.8 ko:K03671,ko:K03672 ko04621,ko05418,map04621,map05418 ko00000,ko00001,ko01000,ko03110 Bacteria 2IQ9T@201174,COG3118@1,COG3118@2 NA|NA|NA O belongs to the thioredoxin family MAG.T12.14_01122 1184609.KILIM_019_00760 1.3e-128 466.1 Dermatophilaceae trxB GO:0000166,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.9,4.3.1.9 ko:K00384,ko:K22345 ko00030,ko00450,map00030,map00450 R01544,R02016,R03596,R09372 RC00013,RC00544,RC02518,RC02873 ko00000,ko00001,ko01000 iPC815.YPO1374 Bacteria 2GKD2@201174,4F6I4@85018,COG0492@1,COG0492@2 NA|NA|NA O Pyridine nucleotide-disulphide oxidoreductase MAG.T12.14_01123 1120950.KB892740_gene2536 8.6e-55 221.5 Propionibacteriales Bacteria 2GM4A@201174,4DN49@85009,COG0515@1,COG0515@2 NA|NA|NA KLT serine threonine protein kinase MAG.T12.14_01125 1120950.KB892740_gene2537 6.2e-108 398.3 Propionibacteriales murJ ko:K03980 ko00000,ko01011,ko02000 2.A.66.4 Bacteria 2GKN0@201174,4DNJI@85009,COG0728@1,COG0728@2 NA|NA|NA KLT MviN-like protein MAG.T12.14_01126 1048339.KB913029_gene1652 3.4e-55 223.4 Frankiales Bacteria 2GN00@201174,4ESX8@85013,COG3170@1,COG3170@2 NA|NA|NA NU Tfp pilus assembly protein FimV MAG.T12.14_01127 675635.Psed_6673 8.7e-49 200.7 Pseudonocardiales Bacteria 2I2DG@201174,4E30H@85010,COG1051@1,COG1051@2 NA|NA|NA F Belongs to the Nudix hydrolase family MAG.T12.14_01128 1157632.AQWQ01000003_gene1787 3.3e-176 624.8 Actinobacteria cca 2.7.7.19,2.7.7.72 ko:K00970,ko:K00974 ko03013,ko03018,map03013,map03018 R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016,ko03019 Bacteria 2GMT1@201174,COG0617@1,COG0617@2 NA|NA|NA J tRNA nucleotidyltransferase poly(A) polymerase MAG.T12.14_01129 1463887.KL590002_gene4201 5.8e-20 104.4 Actinobacteria Bacteria 2IIEK@201174,COG1670@1,COG1670@2 NA|NA|NA J Acetyltransferase (GNAT) domain MAG.T12.14_01130 266117.Rxyl_2066 7.5e-115 421.4 Rubrobacteria oatA GO:0000271,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016020,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509 ko:K19172 ko00000,ko02048 Bacteria 2GKI5@201174,4CQDA@84995,COG1835@1,COG1835@2,COG2755@1,COG2755@2 NA|NA|NA I Acyltransferase family MAG.T12.14_01132 1140001.I571_02495 5.1e-36 157.5 Enterococcaceae cca 2.7.7.19,2.7.7.72 ko:K00970,ko:K00974,ko:K19545 ko03013,ko03018,map03013,map03018 R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko01504,ko03016,ko03019 Bacteria 1V1W2@1239,4B2N1@81852,4HVHZ@91061,COG0617@1,COG0617@2 NA|NA|NA J Aminoglycoside-2''-adenylyltransferase MAG.T12.14_01133 1380356.JNIK01000021_gene4538 5.3e-69 267.7 Actinobacteria glpF ko:K02440,ko:K06188 ko00000,ko02000 1.A.8,1.A.8.1,1.A.8.2 Bacteria 2GKK3@201174,COG0580@1,COG0580@2 NA|NA|NA G Belongs to the MIP aquaporin (TC 1.A.8) family MAG.T12.14_01134 1122933.JNIY01000004_gene2358 6e-37 161.0 Cellulomonadaceae Bacteria 2I2GH@201174,4F1NA@85016,COG3583@1,COG3583@2 NA|NA|NA S G5 MAG.T12.14_01135 710696.Intca_0624 1.4e-151 542.7 Intrasporangiaceae Bacteria 2IAMG@201174,4FFB5@85021,COG0427@1,COG0427@2 NA|NA|NA C 4-hydroxybutyrate CoA-transferase MAG.T12.14_01136 1210045.ALNP01000002_gene4122 1.5e-64 252.7 Actinobacteria laaE Bacteria 2GMJM@201174,COG1695@1,COG1695@2 NA|NA|NA K Transcriptional regulator MAG.T12.14_01137 1003195.SCAT_3138 3.6e-175 620.9 Actinobacteria ino1 GO:0003674,GO:0003824,GO:0004512,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009405,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016853,GO:0016872,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659 5.5.1.4 ko:K01858 ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130 R07324 RC01804 ko00000,ko00001,ko01000 Bacteria 2GKHB@201174,COG1260@1,COG1260@2 NA|NA|NA I myo-inositol-1-phosphate synthase MAG.T12.14_01138 1380346.JNIH01000032_gene1139 5.2e-62 245.4 Actinobacteria 2.7.4.9 ko:K00943,ko:K08217 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 br01600,ko00000,ko00001,ko00002,ko01000,ko01504,ko02000 2.A.1.21.1,2.A.1.21.22 Bacteria 2GK5A@201174,COG2270@1,COG2270@2 NA|NA|NA S Major facilitator Superfamily MAG.T12.14_01139 266940.Krad_0077 1.2e-54 219.9 Actinobacteria fhaA GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363 ko:K02283 ko00000,ko02035,ko02044 Bacteria 2GNU2@201174,COG1716@1,COG1716@2 NA|NA|NA T (FHA) domain MAG.T12.14_01140 561175.KB894093_gene3929 1.7e-34 152.5 Streptosporangiales fhaB GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944 Bacteria 2GKA7@201174,4EJS2@85012,COG1716@1,COG1716@2 NA|NA|NA T Inner membrane component of T3SS, cytoplasmic domain MAG.T12.14_01141 1449346.JQMO01000003_gene4362 1.8e-77 297.0 Kitasatospora 3.1.3.16 ko:K20074 ko00000,ko01000,ko01009 Bacteria 2GJ3M@201174,2M11G@2063,COG0631@1,COG0631@2 NA|NA|NA T Protein phosphatase 2C MAG.T12.14_01142 935866.JAER01000017_gene4377 3.7e-119 435.3 Propionibacteriales rodA GO:0002682,GO:0002684,GO:0008150,GO:0009605,GO:0009607,GO:0009987,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051301,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0075136 ko:K03588,ko:K05364,ko:K05837 ko00550,ko04112,map00550,map04112 R04519 RC00005,RC00049 ko00000,ko00001,ko01011,ko02000,ko03036 2.A.103.1 Bacteria 2GJTI@201174,4DPN4@85009,COG0772@1,COG0772@2 NA|NA|NA D Belongs to the SEDS family MAG.T12.14_01143 1120950.KB892743_gene3151 4.8e-130 471.5 Propionibacteriales pbpA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 ko:K05364 ko00550,map00550 R04519 RC00005,RC00049 ko00000,ko00001,ko01011 Bacteria 2GJUQ@201174,4DP0A@85009,COG0768@1,COG0768@2 NA|NA|NA M Penicillin binding protein transpeptidase domain MAG.T12.14_01144 1121946.AUAX01000005_gene5154 9.2e-49 199.5 Micromonosporales groL GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 Bacteria 2GKC9@201174,4D901@85008,COG0459@1,COG0459@2 NA|NA|NA O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions MAG.T12.14_01145 136273.GY22_15155 4.2e-26 124.4 Micrococcaceae Bacteria 1W9Y1@1268,2CR5C@1,2IT0H@201174,32SNF@2 NA|NA|NA MAG.T12.14_01146 1048339.KB913029_gene2124 1.2e-82 313.5 Frankiales gpgS 2.4.1.266,2.4.1.268 ko:K13693,ko:K21349 ko00000,ko01000,ko01003 GT81 Bacteria 2GMKV@201174,4ES7J@85013,COG1215@1,COG1215@2 NA|NA|NA M Glycosyltransferase like family 2 MAG.T12.14_01147 593907.Celgi_0422 1.8e-31 141.7 Cellulomonadaceae Bacteria 2CUM0@1,2IQG7@201174,32SVJ@2,4F1EW@85016 NA|NA|NA S Protein of unknown function (DUF3263) MAG.T12.14_01148 313589.JNB_13298 1.6e-95 356.3 Intrasporangiaceae 3.2.1.26 ko:K01193 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00801,R00802,R02410,R03635,R03921,R06088 RC00028,RC00077 ko00000,ko00001,ko01000 GH32 Bacteria 2H3S0@201174,4FEDK@85021,COG1621@1,COG1621@2 NA|NA|NA G Glycosyl hydrolase family 32 MAG.T12.14_01149 1123320.KB889748_gene4519 7.9e-156 557.0 Actinobacteria thrC1 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 Bacteria 2GNM0@201174,COG0498@1,COG0498@2 NA|NA|NA E Threonine synthase MAG.T12.14_01150 479432.Sros_8912 8.9e-25 119.4 Streptosporangiales 2.7.7.80,2.8.1.11 ko:K03636,ko:K21147 ko04122,map04122 R07459,R07461 RC00043 ko00000,ko00001,ko01000 Bacteria 2IQBT@201174,4EKIY@85012,COG1977@1,COG1977@2 NA|NA|NA H ThiS family MAG.T12.14_01151 479433.Caci_7815 8.4e-181 639.8 Actinobacteria moeB GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008146,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0016782,GO:0019344,GO:0019752,GO:0020012,GO:0030312,GO:0030682,GO:0042783,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071704,GO:0071944,GO:0075136,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.80,2.8.1.11,3.1.2.6 ko:K01069,ko:K21029,ko:K21147 ko00620,ko04122,map00620,map04122 R01736,R07459,R07461 RC00004,RC00043,RC00137 ko00000,ko00001,ko01000 Bacteria 2GJB6@201174,COG0476@1,COG0476@2,COG0607@1,COG0607@2 NA|NA|NA H The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are MAG.T12.14_01152 1120936.KB907209_gene1439 4.3e-78 298.1 Streptosporangiales ssuC ko:K02050 M00188 ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 Bacteria 2GIWG@201174,4EI0V@85012,COG0600@1,COG0600@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component MAG.T12.14_01153 512565.AMIS_73420 5.5e-72 277.7 Micromonosporales ssuB ko:K02049 M00188 ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 Bacteria 2GN33@201174,4DBHB@85008,COG1116@1,COG1116@2 NA|NA|NA P ATPases associated with a variety of cellular activities MAG.T12.14_01154 33876.JNXY01000010_gene2613 9.7e-91 340.5 Micromonosporales ssuA ko:K02051 M00188 ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 iAF987.Gmet_0996 Bacteria 2GK7X@201174,4DBAN@85008,COG0715@1,COG0715@2 NA|NA|NA P ABC transporter, phosphonate, periplasmic substrate-binding protein MAG.T12.14_01155 1206730.BAGA01000093_gene452 1.1e-22 112.8 Nocardiaceae Bacteria 2E7YB@1,2IRTP@201174,332CR@2,4G2XR@85025 NA|NA|NA MAG.T12.14_01156 469383.Cwoe_4490 1.4e-29 137.1 Actinobacteria Bacteria 2IR83@201174,COG2199@1,COG2199@2 NA|NA|NA T diguanylate cyclase MAG.T12.14_01158 351607.Acel_0144 1.6e-74 286.6 Frankiales Bacteria 2GJV7@201174,4ESVM@85013,COG1609@1,COG1609@2 NA|NA|NA K periplasmic binding protein LacI transcriptional regulator MAG.T12.14_01159 710111.FraQA3DRAFT_4644 1.1e-20 106.3 Actinobacteria Bacteria 2GJYB@201174,COG5485@1,COG5485@2 NA|NA|NA S SnoaL-like polyketide cyclase MAG.T12.14_01160 1306406.ASHX01000001_gene4395 4.5e-124 451.1 Actinobacteria yhhW_2 ko:K06911,ko:K06975 ko00000 Bacteria 2GM9P@201174,COG1741@1,COG1741@2,COG2388@1,COG2388@2 NA|NA|NA S Belongs to the pirin family MAG.T12.14_01161 1172188.KB911825_gene3711 1.4e-38 166.0 Intrasporangiaceae Bacteria 2IMM4@201174,4FGQX@85021,COG3832@1,COG3832@2 NA|NA|NA S Polyketide cyclase / dehydrase and lipid transport MAG.T12.14_01162 1128421.JAGA01000002_gene1272 6.1e-30 139.0 unclassified Bacteria 2.7.7.65 ko:K21088 ko02026,map02026 ko00000,ko00001,ko01000 Bacteria 2NP1A@2323,COG5001@1,COG5001@2 NA|NA|NA T Putative diguanylate phosphodiesterase MAG.T12.14_01163 314278.NB231_10523 3e-156 558.1 Gammaproteobacteria fbp 3.1.3.11,4.1.2.13 ko:K01622 ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00003 R00762,R01068,R01070,R02568,R04780 RC00017,RC00438,RC00439 ko00000,ko00001,ko00002,ko01000 Bacteria 1MXM7@1224,1SKUG@1236,COG1980@1,COG1980@2 NA|NA|NA G Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) MAG.T12.14_01164 1035308.AQYY01000002_gene263 1.8e-147 528.9 Clostridia ko:K19265 ko00000,ko01000 Bacteria 1TRS0@1239,247RJ@186801,COG0667@1,COG0667@2 NA|NA|NA C aldo keto reductase MAG.T12.14_01165 68170.KL590486_gene9693 7.6e-45 187.6 Pseudonocardiales ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2IING@201174,4E5D6@85010,COG1277@1,COG1277@2 NA|NA|NA S ABC-2 family transporter protein MAG.T12.14_01166 1227352.C173_04326 1.8e-61 243.0 Paenibacillaceae ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1TPBQ@1239,26VNN@186822,4HBXP@91061,COG1131@1,COG1131@2 NA|NA|NA V Bacitracin ABC transporter, ATP-binding protein MAG.T12.14_01167 110319.CF8_1033 1.5e-18 99.0 Propionibacteriales cbiL ko:K02007,ko:K02009,ko:K16915 ko02010,map02010 M00245,M00246 ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 iAF987.Gmet_2441 Bacteria 2GRUA@201174,4DS6B@85009,COG0310@1,COG0310@2 NA|NA|NA P PDGLE domain MAG.T12.14_01168 1957.JODX01000015_gene1376 3e-53 215.3 Actinobacteria cbiM ko:K02007,ko:K16915 ko02010,map02010 M00245,M00246 ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 Bacteria 2GK2U@201174,COG0310@1,COG0310@2 NA|NA|NA P Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import MAG.T12.14_01170 935866.JAER01000040_gene512 1.2e-103 382.9 Propionibacteriales Bacteria 2GJU1@201174,4DN4M@85009,COG1028@1,COG1028@2 NA|NA|NA IQ KR domain MAG.T12.14_01171 714083.JH370377_gene2640 3e-22 110.9 Microbacteriaceae Bacteria 2DNW5@1,2IQ5T@201174,32ZGI@2,4FQ68@85023 NA|NA|NA S Rho termination factor, N-terminal domain MAG.T12.14_01175 67352.JODS01000002_gene1441 2.5e-35 154.8 Actinobacteria yjqA Bacteria 2IHVS@201174,3172B@2,arCOG12631@1 NA|NA|NA S Bacterial PH domain MAG.T12.14_01176 471853.Bcav_3179 7.6e-97 360.9 Actinobacteria Bacteria 2H8PB@201174,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily MAG.T12.14_01177 1032480.MLP_35440 4.3e-56 224.2 Propionibacteriales Bacteria 2ISME@201174,4DV13@85009,COG4767@1,COG4767@2 NA|NA|NA V VanZ like family MAG.T12.14_01178 367299.JOEE01000002_gene2522 2.1e-187 661.8 Intrasporangiaceae Bacteria 2GWBV@201174,4FE3R@85021,COG1672@1,COG1672@2 NA|NA|NA S AAA ATPase domain MAG.T12.14_01180 926564.KI911673_gene6308 4.8e-29 134.8 Actinobacteria Bacteria 2HRC6@201174,COG1280@1,COG1280@2 NA|NA|NA E Sap, sulfolipid-1-addressing protein MAG.T12.14_01182 1121952.ATXT01000015_gene306 1.5e-65 256.9 Microbacteriaceae Bacteria 2AU69@1,2IFP7@201174,31JT7@2,4FRYV@85023 NA|NA|NA MAG.T12.14_01183 1172188.KB911820_gene2380 1e-92 346.3 Intrasporangiaceae Bacteria 2GMZV@201174,4FGJN@85021,COG0262@1,COG0262@2 NA|NA|NA H Deaminase reductase MAG.T12.14_01184 298655.KI912267_gene6624 1.7e-142 512.7 Frankiales yndJ Bacteria 28KUD@1,2IACK@201174,2ZAB6@2,4EUQM@85013 NA|NA|NA MAG.T12.14_01185 1380354.JIAN01000005_gene2775 6.5e-108 397.1 Actinobacteria MA20_35565 4.1.3.30 ko:K03417 ko00640,map00640 R00409 RC00286,RC00287 ko00000,ko00001,ko01000 Bacteria 2GMQ4@201174,COG2513@1,COG2513@2 NA|NA|NA G COG2513 PEP phosphonomutase and related enzymes MAG.T12.14_01186 1454010.JEOE01000008_gene1885 1.1e-154 553.1 Actinobacteria Bacteria 2GK3A@201174,COG1680@1,COG1680@2 NA|NA|NA V Beta-lactamase class C and other penicillin binding proteins MAG.T12.14_01187 717774.Marme_3571 6.5e-17 95.1 Bacteria Bacteria COG1357@1,COG1357@2 NA|NA|NA S protein homooligomerization MAG.T12.14_01189 58123.JOFJ01000012_gene5412 1.4e-101 376.3 Streptosporangiales ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GKEH@201174,4ENNZ@85012,COG1131@1,COG1131@2 NA|NA|NA V AAA domain, putative AbiEii toxin, Type IV TA system MAG.T12.14_01190 58123.JOFJ01000012_gene5413 1.1e-111 410.6 Streptosporangiales ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GMSI@201174,4EPCM@85012,COG3559@1,COG3559@2 NA|NA|NA M Exporter of polyketide MAG.T12.14_01191 710421.Mycch_2936 1.3e-102 379.8 Mycobacteriaceae ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 23350@1762,2GKEH@201174,COG1131@1,COG1131@2 NA|NA|NA V ABC transporter MAG.T12.14_01192 710421.Mycch_2937 2.3e-115 422.9 Bacteria ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria COG3559@1,COG3559@2 NA|NA|NA M Exporter of polyketide antibiotics MAG.T12.14_01193 1304865.JAGF01000001_gene2616 2.6e-86 325.9 Actinobacteria Bacteria 2GKX0@201174,COG0262@1,COG0262@2 NA|NA|NA H bifunctional deaminase-reductase domain protein MAG.T12.14_01195 1385519.N801_06575 7.2e-173 613.6 Intrasporangiaceae Bacteria 2GJE2@201174,4FHMX@85021,COG3103@1,COG4991@2 NA|NA|NA T Peptidoglycan-binding protein MAG.T12.14_01198 1121372.AULK01000001_gene1922 3e-78 298.5 Microbacteriaceae Bacteria 2GJUE@201174,4FPKA@85023,COG2267@1,COG2267@2 NA|NA|NA I Alpha/beta hydrolase family MAG.T12.14_01199 1298863.AUEP01000017_gene4145 1.3e-147 530.0 Propionibacteriales sulP GO:0003333,GO:0003674,GO:0005215,GO:0005310,GO:0005326,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0008272,GO:0008509,GO:0008514,GO:0015075,GO:0015103,GO:0015116,GO:0015138,GO:0015141,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015238,GO:0015318,GO:0015556,GO:0015698,GO:0015711,GO:0015740,GO:0015741,GO:0015744,GO:0015800,GO:0015807,GO:0015810,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070778,GO:0071422,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0098656,GO:0098660,GO:0098661,GO:1901682,GO:1902358,GO:1902475,GO:1903825,GO:1905039 ko:K03321 ko00000,ko02000 2.A.53.3 iSbBS512_1146.SbBS512_E1370 Bacteria 2GJCB@201174,4DNAM@85009,COG0659@1,COG0659@2 NA|NA|NA P Sulfate permease family MAG.T12.14_01200 1298863.AUEP01000017_gene4144 8.8e-32 142.9 Propionibacteriales arsR9 ko:K03892 ko00000,ko03000 Bacteria 2IKK2@201174,4DRX6@85009,COG0640@1,COG0640@2 NA|NA|NA K helix_turn_helix, Arsenical Resistance Operon Repressor MAG.T12.14_01201 1001240.GY21_03890 4.7e-163 581.3 Microbacteriaceae hycE ko:K14089 ko00000 Bacteria 2GYM5@201174,4FSFF@85023,COG3261@1,COG3261@2,COG3262@1,COG3262@2 NA|NA|NA C Respiratory-chain NADH dehydrogenase, 49 Kd subunit MAG.T12.14_01202 196162.Noca_4466 5.8e-139 501.1 Propionibacteriales hyfF ko:K12141 ko00000,ko01000 Bacteria 2HAC7@201174,4DTN6@85009,COG0651@1,COG0651@2 NA|NA|NA CP Proton-conducting membrane transporter MAG.T12.14_01203 1001240.GY21_03900 8.6e-45 187.2 Microbacteriaceae hyfE GO:0008150,GO:0040007 ko:K12140 ko00000,ko01000 Bacteria 2HQ3P@201174,4FQSR@85023,COG4237@1,COG4237@2 NA|NA|NA C Hydrogenase 4 membrane MAG.T12.14_01204 1001240.GY21_03905 1.5e-95 356.3 Microbacteriaceae hycD Bacteria 2GJFM@201174,4FPM3@85023,COG0650@1,COG0650@2 NA|NA|NA C NADH dehydrogenase MAG.T12.14_01205 196162.Noca_4469 4.4e-190 671.4 Propionibacteriales hyfB Bacteria 2HAC7@201174,4DSYG@85009,COG0651@1,COG0651@2 NA|NA|NA CP Proton-conducting membrane transporter MAG.T12.14_01206 196162.Noca_4470 4.6e-59 234.2 Propionibacteriales hycG Bacteria 2IDTD@201174,4DUTR@85009,COG3260@1,COG3260@2 NA|NA|NA C NADH ubiquinone oxidoreductase, 20 Kd subunit MAG.T12.14_01207 590998.Celf_2528 7.3e-106 391.0 Cellulomonadaceae Bacteria 2GJEG@201174,4F1NE@85016,COG4585@1,COG4585@2 NA|NA|NA T PFAM histidine kinase dimerisation and phosphoacceptor region MAG.T12.14_01208 590998.Celf_2529 3.8e-92 344.7 Cellulomonadaceae tcsR2 Bacteria 2GJ46@201174,4F1QA@85016,COG2197@1,COG2197@2 NA|NA|NA T PFAM response regulator receiver MAG.T12.14_01209 1454010.JEOE01000003_gene259 9e-107 393.3 Actinobacteria ko:K02003 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GJN6@201174,COG1136@1,COG1136@2 NA|NA|NA V ABC transporter MAG.T12.14_01210 593907.Celgi_1060 3.7e-170 605.5 Cellulomonadaceae ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 2H37M@201174,4F1Y9@85016,COG3127@1,COG3127@2 NA|NA|NA Q MacB-like periplasmic core domain MAG.T12.14_01211 1121017.AUFG01000012_gene1807 6.4e-206 723.8 Intrasporangiaceae malS GO:0003674,GO:0003824,GO:0004470,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006090,GO:0006108,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016614,GO:0016615,GO:0019752,GO:0032787,GO:0043436,GO:0043648,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071704 1.1.1.38 ko:K00027 ko00620,ko01200,ko02020,map00620,map01200,map02020 R00214 RC00105 ko00000,ko00001,ko01000 Bacteria 2GJAJ@201174,4FG5T@85021,COG0281@1,COG0281@2 NA|NA|NA C Malic enzyme, NAD binding domain MAG.T12.14_01212 443218.AS9A_2146 2e-50 205.3 Actinobacteria Bacteria 2CAJE@1,2IMDF@201174,33XCP@2 NA|NA|NA MAG.T12.14_01213 590998.Celf_0701 1.2e-16 92.8 Bacteria cbpA 2.4.1.333 ko:K21298 ko00000,ko01000 GH94 Bacteria COG3459@1,COG3459@2 NA|NA|NA G carbohydrate binding MAG.T12.14_01214 1463909.KL585957_gene2958 0.0 1080.5 Actinobacteria bgl2 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 GH3 Bacteria 2GJ5H@201174,COG1472@1,COG1472@2 NA|NA|NA G hydrolase, family 3 MAG.T12.14_01215 526225.Gobs_1145 4.7e-48 197.6 Frankiales MA20_23315 Bacteria 2IIUB@201174,4ESS1@85013,COG1765@1,COG1765@2 NA|NA|NA O PFAM OsmC family protein MAG.T12.14_01216 446471.Xcel_3344 2.1e-53 216.1 Promicromonosporaceae 1.20.4.1 ko:K03741,ko:K03892 ko00000,ko01000,ko03000 Bacteria 2IHR3@201174,4F4G0@85017,COG0394@1,COG0394@2,COG0640@1,COG0640@2 NA|NA|NA T Low molecular weight phosphatase family MAG.T12.14_01217 446465.Bfae_31180 5.1e-28 130.6 Dermabacteraceae ko:K03892 ko00000,ko03000 Bacteria 2IQDH@201174,4FD6A@85020,COG0640@1,COG0640@2 NA|NA|NA K helix_turn_helix, Arsenical Resistance Operon Repressor MAG.T12.14_01218 861299.J421_2256 1.3e-84 319.7 Gemmatimonadetes arsM 2.1.1.137 ko:K07755 ko00000,ko01000 Bacteria 1ZSM8@142182,COG0500@1,COG2226@2 NA|NA|NA Q Hypothetical methyltransferase MAG.T12.14_01219 1397693.KK211187_gene1704 9.2e-202 709.9 Bacillales incertae sedis cdr2 Bacteria 1TPWW@1239,3WENZ@539002,4HA11@91061,COG0446@1,COG0446@2,COG0607@1,COG0607@2 NA|NA|NA P Belongs to the sulfur carrier protein TusA family MAG.T12.14_01220 1240349.ANGC01000004_gene1728 3.6e-108 398.3 Nocardiaceae alx ko:K05794 ko00000 Bacteria 2GIWU@201174,4FUZ0@85025,COG0861@1,COG0861@2 NA|NA|NA P Integral membrane protein TerC family MAG.T12.14_01221 471852.Tcur_3420 2.8e-81 308.5 Streptosporangiales trmD GO:0000287,GO:0001510,GO:0002939,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050518,GO:0052906,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228,4.6.1.12 ko:K00554,ko:K01770 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R00597,R05637 RC00002,RC00003,RC00334,RC01440 ko00000,ko00001,ko00002,ko01000,ko03016 Bacteria 2GJ1G@201174,4EGB1@85012,COG0336@1,COG0336@2 NA|NA|NA J Belongs to the RNA methyltransferase TrmD family MAG.T12.14_01222 479433.Caci_1514 7.6e-38 163.7 Actinobacteria rimM GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 ko:K02860 ko00000,ko03009 Bacteria 2GK4I@201174,COG0806@1,COG0806@2 NA|NA|NA J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes MAG.T12.14_01223 1274.HX89_09660 2e-21 108.2 Dermacoccaceae CP_0960 GO:0008150,GO:0040007 ko:K06960 ko00000 Bacteria 1ZW6W@145357,2IQ4C@201174,COG1837@1,COG1837@2 NA|NA|NA S KH domain MAG.T12.14_01224 561175.KB894094_gene1857 1.1e-45 189.5 Streptosporangiales rpsP GO:0000028,GO:0000217,GO:0000400,GO:0003674,GO:0003676,GO:0003677,GO:0003735,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006259,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016787,GO:0016788,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02959 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011,ko03029 Bacteria 2IKU0@201174,4EJRE@85012,COG0228@1,COG0228@2 NA|NA|NA J Ribosomal protein S16 MAG.T12.14_01225 1464048.JNZS01000025_gene780 1.6e-118 433.0 Micromonosporales ycaQ ko:K09927 ko00000 Bacteria 2GJM7@201174,4DA91@85008,COG3214@1,COG3214@2 NA|NA|NA S Winged helix DNA-binding domain MAG.T12.14_01226 446471.Xcel_1165 3.4e-185 654.8 Promicromonosporaceae ffh GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006605,GO:0006612,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0030312,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0040007,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046907,GO:0048500,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0071944,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1990904 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 Bacteria 2GK4R@201174,4F37P@85017,COG0541@1,COG0541@2 NA|NA|NA U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY MAG.T12.14_01227 1380356.JNIK01000018_gene821 5.3e-33 148.7 Frankiales Bacteria 2ICMJ@201174,4ETKK@85013,COG0392@1,COG0392@2 NA|NA|NA S Lysylphosphatidylglycerol synthase TM region MAG.T12.14_01228 105420.BBPO01000125_gene4715 2.9e-15 87.8 Streptacidiphilus Bacteria 2BVHC@1,2IN31@201174,2NMD9@228398,32QVY@2 NA|NA|NA MAG.T12.14_01230 1048339.KB913029_gene3508 5.8e-210 737.6 Frankiales glnD GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006355,GO:0006464,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0006808,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0008652,GO:0008773,GO:0009058,GO:0009064,GO:0009084,GO:0009605,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0018175,GO:0018177,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0044464,GO:0045893,GO:0045935,GO:0046394,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070566,GO:0070569,GO:0070887,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0071944,GO:0080090,GO:0090293,GO:0140096,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901698,GO:1901699,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 1.1.1.3,1.4.1.2,2.7.7.19,2.7.7.42,2.7.7.59,2.7.7.72,2.7.7.89 ko:K00003,ko:K00970,ko:K00974,ko:K00982,ko:K00990,ko:K06950,ko:K15371 ko00220,ko00250,ko00260,ko00270,ko00300,ko00430,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,ko02020,ko03013,ko03018,map00220,map00250,map00260,map00270,map00300,map00430,map00910,map01100,map01110,map01120,map01130,map01230,map02020,map03013,map03018 M00017,M00018 R00243,R01773,R01775,R09382,R09383,R09384,R09386 RC00006,RC00078,RC00087,RC02799 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 Bacteria 2GMKT@201174,4ERG2@85013,COG2844@1,COG2844@2 NA|NA|NA O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen MAG.T12.14_01231 1449353.JQMQ01000005_gene2028 1.7e-46 191.8 Streptacidiphilus glnB ko:K04751 ko02020,map02020 ko00000,ko00001 Bacteria 2IKN1@201174,2NIJK@228398,COG0347@1,COG0347@2 NA|NA|NA E Nitrogen regulatory protein P-II MAG.T12.14_01232 1306174.JODP01000016_gene7106 1.3e-159 569.7 Actinobacteria amt GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03320 ko00000,ko02000 1.A.11 iNJ661.Rv2920c Bacteria 2GIZK@201174,COG0004@1,COG0004@2 NA|NA|NA P Ammonium transporter MAG.T12.14_01233 591167.Sfla_1718 8.6e-124 450.3 Actinobacteria ftsY GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 Bacteria 2GJQH@201174,COG0552@1,COG0552@2 NA|NA|NA U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) MAG.T12.14_01234 1298863.AUEP01000002_gene1371 0.0 1124.8 Propionibacteriales smc GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 ko:K03529,ko:K19171 ko00000,ko02048,ko03036 Bacteria 2GK93@201174,4DN2T@85009,COG1196@1,COG1196@2 NA|NA|NA D Required for chromosome condensation and partitioning MAG.T12.14_01236 479431.Namu_1888 2.5e-17 94.7 Frankiales acyP GO:0003674,GO:0003824,GO:0003998,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016787,GO:0016817,GO:0016818,GO:0050896 3.6.1.7 ko:K01512 ko00620,ko00627,ko01120,map00620,map00627,map01120 R00317,R01421,R01515 RC00043 ko00000,ko00001,ko01000 iSB619.SA_RS07020,iSBO_1134.SBO_2263,iSF_1195.SF0969,iSFxv_1172.SFxv_1053,iS_1188.S1036 Bacteria 2IQ4M@201174,4ETFK@85013,COG1254@1,COG1254@2 NA|NA|NA C Belongs to the acylphosphatase family MAG.T12.14_01237 1449069.JMLO01000001_gene1725 5.5e-81 307.8 Nocardiaceae fpg GO:0000702,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0008152,GO:0008534,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034039,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 2GJNT@201174,4FV1G@85025,COG0266@1,COG0266@2 NA|NA|NA L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates MAG.T12.14_01238 561175.KB894094_gene1867 4.8e-75 287.7 Streptosporangiales rnc GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 Bacteria 2GKER@201174,4EGGX@85012,COG0571@1,COG0571@2 NA|NA|NA K Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism MAG.T12.14_01239 227882.SAV_2666 5.5e-17 92.8 Actinobacteria rpmF GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904 ko:K02911 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011,ko03029 Bacteria 2GQP3@201174,COG0333@1,COG0333@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL32 family MAG.T12.14_01240 110319.CF8_2880 6.2e-51 207.2 Propionibacteriales yceD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 ko:K07040 ko00000 Bacteria 2GJTS@201174,4DQUU@85009,COG1399@1,COG1399@2 NA|NA|NA S Uncharacterized ACR, COG1399 MAG.T12.14_01241 1463921.JODF01000032_gene2667 1.8e-16 92.8 Actinobacteria Bacteria 2GNBF@201174,COG0711@1,COG0711@2 NA|NA|NA C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) MAG.T12.14_01242 882086.SacxiDRAFT_1033 1.1e-59 236.1 Pseudonocardiales coaD GO:0003674,GO:0003824,GO:0004595,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016043,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0022607,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034214,GO:0034641,GO:0034654,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0055086,GO:0065003,GO:0070566,GO:0071704,GO:0071840,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 2GN1S@201174,4E33S@85010,COG0669@1,COG0669@2 NA|NA|NA H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate MAG.T12.14_01243 1033730.CAHG01000016_gene241 4.3e-42 177.9 Propionibacteriales rsmD GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052913,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.171 ko:K08316 R07234 RC00003 ko00000,ko01000,ko03009 Bacteria 2GQ3G@201174,4DQZ1@85009,COG0742@1,COG0742@2 NA|NA|NA L Conserved hypothetical protein 95 MAG.T12.14_01244 1123322.KB904683_gene4838 3.9e-224 784.6 Actinobacteria recG GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 ko:K03655 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 2GKA3@201174,COG1200@1,COG1200@2 NA|NA|NA L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) MAG.T12.14_01245 1123320.KB889676_gene2888 1.1e-109 404.1 Actinobacteria dak3 2.7.1.28,2.7.1.29,4.6.1.15 ko:K00863,ko:K07030 ko00051,ko00561,ko00680,ko01100,ko01120,ko01200,ko04622,map00051,map00561,map00680,map01100,map01120,map01200,map04622 M00344 R01011,R01059 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKII@201174,COG1461@1,COG1461@2 NA|NA|NA S Dihydroxyacetone kinase MAG.T12.14_01246 446471.Xcel_2281 4.9e-27 126.3 Promicromonosporaceae rpmB GO:0003674,GO:0003735,GO:0005198 ko:K02902 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GQNU@201174,4F4SP@85017,COG0227@1,COG0227@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL28 family MAG.T12.14_01247 1463887.KL589967_gene6542 3.3e-90 338.6 Actinobacteria thiL GO:0008150,GO:0040007 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv2977c,iYO844.BSU05900 Bacteria 2GP6E@201174,COG0611@1,COG0611@2 NA|NA|NA H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 MAG.T12.14_01248 471857.Svir_09180 4.8e-24 116.7 Pseudonocardiales Bacteria 2IQ4Z@201174,4E5C4@85010,COG1522@1,COG1522@2 NA|NA|NA K AsnC family MAG.T12.14_01249 1120950.KB892741_gene2701 2.7e-18 98.6 Propionibacteriales Bacteria 2CQFE@1,2GRVK@201174,32SM3@2,4DS6W@85009 NA|NA|NA S Protein of unknown function (DUF3515) MAG.T12.14_01250 1229780.BN381_60056 8.1e-31 140.6 Actinobacteria rimJ2 Bacteria 2IS6V@201174,COG1670@1,COG1670@2 NA|NA|NA J Acetyltransferase (GNAT) domain MAG.T12.14_01251 1120950.KB892707_gene4586 3.7e-212 744.6 Propionibacteriales 3.4.19.1 ko:K01303 ko00000,ko01000,ko01002 Bacteria 2GJW4@201174,4DTZJ@85009,COG1506@1,COG1506@2 NA|NA|NA E Dienelactone hydrolase family MAG.T12.14_01252 1048339.KB913029_gene3486 1.4e-121 443.0 Frankiales ddl GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008716,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0016874,GO:0016879,GO:0016881,GO:0044424,GO:0044444,GO:0044464,GO:0050896 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 iAF1260.b0381,iB21_1397.B21_00332,iBWG_1329.BWG_0265,iE2348C_1286.E2348C_0317,iEC042_1314.EC042_0413,iEC55989_1330.EC55989_0386,iECBD_1354.ECBD_3283,iECB_1328.ECB_00328,iECDH10B_1368.ECDH10B_0338,iECDH1ME8569_1439.ECDH1ME8569_0367,iECD_1391.ECD_00328,iECH74115_1262.ECH74115_0453,iECIAI1_1343.ECIAI1_0377,iECIAI39_1322.ECIAI39_0301,iECO103_1326.ECO103_0356,iECO111_1330.ECO111_0411,iECO26_1355.ECO26_0414,iECSE_1348.ECSE_0401,iECSP_1301.ECSP_0441,iECs_1301.ECs0431,iETEC_1333.ETEC_0434,iEcDH1_1363.EcDH1_3227,iEcE24377_1341.EcE24377A_0406,iEcHS_1320.EcHS_A0447,iEcSMS35_1347.EcSMS35_0410,iEcolC_1368.EcolC_3251,iJO1366.b0381,iJR904.b0381,iSF_1195.SF0232,iSFxv_1172.SFxv_0245,iS_1188.S0254,iUMNK88_1353.UMNK88_429,iY75_1357.Y75_RS01965,iZ_1308.Z0477 Bacteria 2GITC@201174,4ERWT@85013,COG1181@1,COG1181@2 NA|NA|NA M Belongs to the D-alanine--D-alanine ligase family MAG.T12.14_01253 1120950.KB892741_gene2699 1e-103 383.6 Propionibacteriales metB 2.5.1.48,4.4.1.8 ko:K01739,ko:K01760 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04941,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00382,RC00420,RC00488,RC00710,RC01245,RC02303,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 Bacteria 2GMD8@201174,4DPBS@85009,COG0626@1,COG0626@2 NA|NA|NA E Cys/Met metabolism PLP-dependent enzyme MAG.T12.14_01254 397278.JOJN01000003_gene1964 2.6e-52 212.2 Propionibacteriales Bacteria 2I655@201174,4DSYQ@85009,COG3064@1,COG3064@2 NA|NA|NA M Membrane MAG.T12.14_01255 1288079.AUKN01000001_gene4099 1.2e-116 426.4 Actinobacteria gpsA 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 R00842,R00844 RC00029 ko00000,ko00001,ko01000 Bacteria 2GJSD@201174,COG0240@1,COG0240@2 NA|NA|NA I Glycerol-3-phosphate dehydrogenase MAG.T12.14_01256 1123320.KB889676_gene2895 4.1e-64 251.5 Actinobacteria plsC2 Bacteria 2GKVA@201174,COG0204@1,COG0204@2 NA|NA|NA I Acyltransferase MAG.T12.14_01257 471852.Tcur_3460 2e-19 102.8 Streptosporangiales hup GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006355,GO:0006725,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010106,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016043,GO:0019219,GO:0019222,GO:0019725,GO:0030003,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0040007,GO:0042262,GO:0042592,GO:0042594,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0046916,GO:0048518,GO:0048522,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0060255,GO:0065007,GO:0065008,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090143,GO:0090304,GO:0097100,GO:0097159,GO:0098771,GO:0140110,GO:1901360,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 ko:K03530 ko00000,ko03032,ko03036,ko03400 Bacteria 2GV0M@201174,4EK5F@85012,COG0776@1,COG0776@2 NA|NA|NA L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions MAG.T12.14_01258 1121017.AUFG01000045_gene3633 8e-76 290.0 Intrasporangiaceae leuD GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016020,GO:0016053,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 iNJ661.Rv2987c Bacteria 2GJ8Z@201174,4FE44@85021,COG0066@1,COG0066@2 NA|NA|NA E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate MAG.T12.14_01259 1122239.AULS01000001_gene1844 3.4e-185 654.4 Microbacteriaceae leuC GO:0003674,GO:0003824,GO:0003861,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009316,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 iEcE24377_1341.EcE24377A_0075,iPC815.YPO0531 Bacteria 2GKT7@201174,4FKI7@85023,COG0065@1,COG0065@2 NA|NA|NA E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate MAG.T12.14_01260 1449353.JQMQ01000005_gene1847 1e-63 249.2 Streptacidiphilus yjjK GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 Bacteria 2GKBQ@201174,2NGB3@228398,COG0488@1,COG0488@2 NA|NA|NA S ABC transporter MAG.T12.14_01261 314230.DSM3645_19063 0.0 1179.9 Planctomycetes dld ko:K18930 ko00000 Bacteria 2IYAH@203682,COG0247@1,COG0247@2,COG0277@1,COG0277@2 NA|NA|NA C FAD linked oxidases, C-terminal domain MAG.T12.14_01262 983917.RGE_19390 6.9e-114 417.9 unclassified Burkholderiales ko:K03281,ko:K07085 ko00000 2.A.49,2.A.81 Bacteria 1KNQF@119065,1MUVM@1224,2VN42@28216,COG0569@1,COG0569@2,COG2985@1,COG2985@2 NA|NA|NA P Predicted Permease Membrane Region MAG.T12.14_01263 1137269.AZWL01000007_gene4285 7.9e-166 590.5 Actinobacteria 3.2.1.10,3.2.1.20,3.2.1.93 ko:K01182,ko:K01187,ko:K01226 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00028,R00801,R00802,R00837,R01718,R01791,R06087,R06088,R06113,R06199 RC00028,RC00049,RC00059,RC00077,RC00451 ko00000,ko00001,ko01000 GH13,GH31 Bacteria 2GKS4@201174,COG0366@1,COG0366@2 NA|NA|NA G alpha amylase, catalytic MAG.T12.14_01264 1463885.KL578480_gene3542 5.3e-42 177.2 Actinobacteria glbO GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008144,GO:0008150,GO:0015669,GO:0015671,GO:0015893,GO:0016020,GO:0019825,GO:0020037,GO:0036094,GO:0042221,GO:0042493,GO:0044464,GO:0046906,GO:0048037,GO:0050896,GO:0051179,GO:0051234,GO:0071944,GO:0097159,GO:1901363 ko:K06886 ko00000 Bacteria 2IKPF@201174,COG2346@1,COG2346@2 NA|NA|NA O PFAM globin MAG.T12.14_01265 1123320.KB889629_gene7846 1.9e-188 665.6 Actinobacteria Bacteria 2GIZA@201174,COG0702@1,COG0702@2 NA|NA|NA GM Nad-dependent epimerase dehydratase MAG.T12.14_01266 1089455.MOPEL_132_00510 5e-59 235.0 Dermatophilaceae ko:K22044 ko00000,ko02000 1.A.23.3 Bacteria 2GMFK@201174,4F6NP@85018,COG0668@1,COG0668@2 NA|NA|NA M Mechanosensitive ion channel MAG.T12.14_01267 1454010.JEOE01000011_gene2418 1.4e-218 766.1 Cellulomonadaceae malQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.4.1.18,2.4.1.25,3.2.1.196,5.4.99.15 ko:K00700,ko:K00705,ko:K02438,ko:K06044 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01824,R02110,R02111,R05196,R09995 RC00049 ko00000,ko00001,ko00002,ko01000,ko04147 CBM48,GH13,GH77 iJN678.malQ Bacteria 2GM5Z@201174,4F0RR@85016,COG1640@1,COG1640@2 NA|NA|NA G PFAM glycoside hydrolase family 77 MAG.T12.14_01268 471852.Tcur_1349 2.6e-272 944.9 Streptosporangiales 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 Bacteria 2GJJ4@201174,4EHVC@85012,COG0308@1,COG0308@2 NA|NA|NA E ERAP1-like C-terminal domain MAG.T12.14_01269 446471.Xcel_1105 2.1e-55 221.9 Promicromonosporaceae rpiB 5.3.1.6 ko:K01808 ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKJG@201174,4F4DS@85017,COG0698@1,COG0698@2 NA|NA|NA G Ribose/Galactose Isomerase MAG.T12.14_01270 367299.JOEE01000002_gene2367 4.8e-60 238.8 Intrasporangiaceae dacB 3.4.16.4 ko:K07259 ko00550,map00550 ko00000,ko00001,ko01000,ko01002,ko01011 Bacteria 2GJPH@201174,4FGTP@85021,COG2027@1,COG2027@2 NA|NA|NA M D-Ala-D-Ala carboxypeptidase 3 (S13) family MAG.T12.14_01271 1123023.JIAI01000002_gene4736 1.6e-163 582.4 Pseudonocardiales rocD GO:0003674,GO:0003824,GO:0004587,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016740,GO:0016769,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.6.1.11,2.6.1.13,2.6.1.17 ko:K00819,ko:K00821 ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R00667,R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 iYO844.BSU40340 Bacteria 2GK0J@201174,4DZYH@85010,COG4992@1,COG4992@2 NA|NA|NA E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family MAG.T12.14_01272 1313172.YM304_27660 3e-209 735.3 Bacteria Bacteria COG0433@1,COG0433@2 NA|NA|NA S helicase activity MAG.T12.14_01273 397278.JOJN01000011_gene1599 2.5e-84 319.3 Propionibacteriales Bacteria 2GJM3@201174,4DNDV@85009,COG1316@1,COG1316@2 NA|NA|NA K Cell envelope-related transcriptional attenuator domain MAG.T12.14_01274 1192034.CAP_2687 8.8e-61 240.7 Myxococcales 2.7.1.15,2.7.1.187,2.7.1.45 ko:K00852,ko:K00874,ko:K19978 ko00030,ko00525,ko01100,ko01120,ko01130,ko01200,map00030,map00525,map01100,map01120,map01130,map01200 M00061,M00308,M00631 R01051,R01541,R02750,R11184 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 1RBE0@1224,2X9ZP@28221,2YVZZ@29,4386N@68525,COG0524@1,COG0524@2 NA|NA|NA G pfkB family carbohydrate kinase MAG.T12.14_01275 765910.MARPU_00780 1.7e-104 386.3 Chromatiales gdh 1.4.1.4 ko:K00262 ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100 R00248 RC00006,RC02799 ko00000,ko00001,ko01000 Bacteria 1NPPY@1224,1RRKZ@1236,1WWQA@135613,COG4198@1,COG4198@2 NA|NA|NA S Protein of unknown function (DUF1015) MAG.T12.14_01276 909613.UO65_1997 2.6e-65 255.0 Pseudonocardiales ybhB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 ko:K06910 ko00000 Bacteria 2GMIG@201174,4DYXA@85010,COG1881@1,COG1881@2 NA|NA|NA S TIGRFAM Raf kinase inhibitor-like protein, YbhB YbcL family MAG.T12.14_01278 2045.KR76_01175 1e-31 143.7 Propionibacteriales Bacteria 2I8Y7@201174,4DU0I@85009,COG2197@1,COG2197@2 NA|NA|NA KT Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain MAG.T12.14_01279 56107.Cylst_0426 9.2e-44 185.3 Nostocales Bacteria 1GQ7S@1117,1HRXM@1161,COG0823@1,COG0823@2,COG5276@1,COG5276@2 NA|NA|NA Q LVIVD repeat MAG.T12.14_01280 1151122.AQYD01000007_gene568 2.9e-64 251.9 Microbacteriaceae phhB 3.5.4.33,4.2.1.96 ko:K01724,ko:K11991 ko00790,map00790 R04734,R10223 RC00477,RC01208 ko00000,ko00001,ko01000,ko03016,ko04147 Bacteria 2IHZE@201174,4FP56@85023,COG0596@1,COG0596@2,COG2154@1,COG2154@2 NA|NA|NA H Pterin 4 alpha carbinolamine dehydratase MAG.T12.14_01281 590998.Celf_1077 1.4e-56 226.5 Cellulomonadaceae ko:K02081,ko:K03436 ko00000,ko03000 Bacteria 2GKWM@201174,4F32F@85016,COG1349@1,COG1349@2 NA|NA|NA K DeoR C terminal sensor domain MAG.T12.14_01282 263358.VAB18032_19950 8.4e-92 343.6 Micromonosporales estA ko:K03930 ko00000,ko01000 CE1 Bacteria 2GJX4@201174,4D9HJ@85008,COG0627@1,COG0627@2 NA|NA|NA S Putative esterase MAG.T12.14_01284 1265502.KB905943_gene2772 1.7e-266 925.2 Comamonadaceae fadH 1.3.1.34 ko:K00219 ko00000,ko01000 Bacteria 1MVE0@1224,2VIW3@28216,4ABSX@80864,COG0446@1,COG0446@2,COG1902@1,COG1902@2 NA|NA|NA C NADH flavin oxidoreductase NADH oxidase MAG.T12.14_01285 1172188.KB911822_gene882 2.7e-145 522.3 Intrasporangiaceae ko:K06158 ko00000,ko03012 Bacteria 2GK9S@201174,4FFDZ@85021,COG0488@1,COG0488@2 NA|NA|NA S ABC transporter, ATP-binding protein MAG.T12.14_01286 1035308.AQYY01000001_gene3456 2e-58 233.0 Clostridia Bacteria 1UZ78@1239,24BM7@186801,COG3965@1,COG3965@2 NA|NA|NA P cation diffusion facilitator family transporter MAG.T12.14_01288 1246995.AFR_19415 6.2e-33 146.7 Micromonosporales ko:K10947 ko00000,ko03000 Bacteria 2IQ51@201174,4DFEK@85008,COG1695@1,COG1695@2 NA|NA|NA K Transcriptional regulator PadR-like family MAG.T12.14_01290 710696.Intca_1058 1.9e-50 205.3 Intrasporangiaceae icmB 5.4.99.13,5.4.99.2,5.4.99.63 ko:K01849,ko:K11942,ko:K14447 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R00833,R09292 RC00395,RC02835 ko00000,ko00001,ko00002,ko01000 Bacteria 2IFJD@201174,4FGQ3@85021,COG2185@1,COG2185@2 NA|NA|NA I B12 binding domain MAG.T12.14_01291 561175.KB894093_gene3300 3e-273 948.0 Streptosporangiales pcrA GO:0000018,GO:0000166,GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030312,GO:0030554,GO:0031323,GO:0031324,GO:0032392,GO:0032508,GO:0032552,GO:0032554,GO:0032558,GO:0032564,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0036094,GO:0040007,GO:0042623,GO:0043138,GO:0043140,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0045910,GO:0045934,GO:0046483,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 2GISS@201174,4EFMA@85012,COG0210@1,COG0210@2 NA|NA|NA L UvrD-like helicase C-terminal domain MAG.T12.14_01292 1504319.GM45_2400 3.2e-46 193.0 Actinobacteria ko:K01446 R04112 RC00064,RC00141 ko00000 Bacteria 2IG5X@201174,COG3409@1,COG3409@2 NA|NA|NA M Peptidoglycan-binding domain 1 protein MAG.T12.14_01293 1146883.BLASA_4228 1.3e-75 289.7 Frankiales Bacteria 2GMVD@201174,4ESNR@85013,COG2120@1,COG2120@2 NA|NA|NA S Evidence 2b Function of strongly homologous gene MAG.T12.14_01294 1304865.JAGF01000001_gene590 1e-22 112.8 Bacteria Bacteria 2E4PN@1,32ZIA@2 NA|NA|NA MAG.T12.14_01295 1394178.AWOO02000003_gene2641 1e-76 293.1 Streptosporangiales degU ko:K07684 ko02020,map02020 M00471 ko00000,ko00001,ko00002,ko02022 Bacteria 2GIVA@201174,4EHIU@85012,COG2197@1,COG2197@2 NA|NA|NA T helix_turn_helix, Lux Regulon MAG.T12.14_01296 58123.JOFJ01000019_gene3792 3.7e-67 262.3 Streptosporangiales tcsS3 Bacteria 2GJ4J@201174,4EG3Q@85012,COG1983@1,COG1983@2,COG4585@1,COG4585@2 NA|NA|NA KT PspC domain MAG.T12.14_01297 1048339.KB913029_gene2814 4.4e-18 99.4 Frankiales Bacteria 2GIVS@201174,4EW85@85013,COG1983@1,COG1983@2 NA|NA|NA KT PFAM PspC domain protein MAG.T12.14_01299 1121946.AUAX01000003_gene1480 3.9e-234 817.4 Micromonosporales guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 iJN746.PP_1032,iSF_1195.SF2553,iSFxv_1172.SFxv_2808,iS_1188.S2725,iYL1228.KPN_02833 Bacteria 2GM09@201174,4DAVN@85008,COG0519@1,COG0519@2 NA|NA|NA F Catalyzes the synthesis of GMP from XMP MAG.T12.14_01300 345341.KUTG_05928 5.2e-198 697.6 Pseudonocardiales choD GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009405,GO:0016491,GO:0016614,GO:0016899,GO:0016995,GO:0044419,GO:0051704,GO:0055114 1.1.3.6 ko:K03333 ko00984,ko01120,map00984,map01120 R01459 RC00146 ko00000,ko00001,ko01000 Bacteria 2GJ3J@201174,4DYHW@85010,COG2303@1,COG2303@2 NA|NA|NA E Catalyzes the oxidation and isomerization of cholesterol to cholestenone (4-cholesten-3-one), which is an initial step in the cholesterol degradation process. Required for virulence MAG.T12.14_01301 1184609.KILIM_065_00100 2e-145 522.7 Dermatophilaceae gabD2 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009013,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016620,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0071944,GO:0072350 1.2.1.16,1.2.1.20,1.2.1.79,1.2.99.10 ko:K00135,ko:K22445 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ95@201174,4F6MX@85018,COG1012@1,COG1012@2 NA|NA|NA C Aldehyde dehydrogenase family MAG.T12.14_01302 105420.BBPO01000010_gene2316 2e-146 526.2 Streptacidiphilus glpD 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 R00848 RC00029 ko00000,ko00001,ko01000 Bacteria 2GJKN@201174,2NHAR@228398,COG0578@1,COG0578@2 NA|NA|NA C C-terminal domain of alpha-glycerophosphate oxidase MAG.T12.14_01303 1120950.KB892783_gene342 2.5e-147 528.5 Propionibacteriales guaB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GKVS@201174,4DN1G@85009,COG0516@1,COG0516@2 NA|NA|NA F IMP dehydrogenase / GMP reductase domain MAG.T12.14_01304 1095767.CAHD01000133_gene1273 1.5e-227 795.4 Cellulomonadaceae guaB GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006183,GO:0006195,GO:0006204,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009125,GO:0009126,GO:0009127,GO:0009128,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009154,GO:0009156,GO:0009158,GO:0009161,GO:0009163,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009169,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009261,GO:0009987,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046037,GO:0046039,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0072523,GO:0090407,GO:0097292,GO:0097293,GO:1901068,GO:1901070,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GITZ@201174,4F0EC@85016,COG0516@1,COG0516@2,COG0517@1,COG0517@2 NA|NA|NA F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth MAG.T12.14_01305 1306174.JODP01000006_gene3624 5.1e-65 254.2 Actinobacteria bldM Bacteria 2GN46@201174,COG2197@1,COG2197@2 NA|NA|NA K Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain MAG.T12.14_01306 710421.Mycch_1110 7.9e-14 84.7 Mycobacteriaceae Bacteria 233QX@1762,2F0NR@1,2GUJF@201174,33TR6@2 NA|NA|NA MAG.T12.14_01307 675635.Psed_5357 5e-58 231.9 Pseudonocardiales litR ko:K22491 ko00000,ko03000 Bacteria 2I8T8@201174,4DZZC@85010,COG0789@1,COG0789@2 NA|NA|NA K MerR HTH family regulatory protein MAG.T12.14_01308 1114959.SZMC14600_05067 3e-34 151.0 Pseudonocardiales whiB3 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0008152,GO:0009273,GO:0009405,GO:0009987,GO:0010565,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0019216,GO:0019217,GO:0019222,GO:0019725,GO:0030312,GO:0031323,GO:0042546,GO:0042592,GO:0043254,GO:0044085,GO:0044087,GO:0044419,GO:0044464,GO:0045454,GO:0048037,GO:0048583,GO:0050789,GO:0050794,GO:0051128,GO:0051536,GO:0051539,GO:0051540,GO:0051704,GO:0055114,GO:0062012,GO:0065007,GO:0065008,GO:0071554,GO:0071766,GO:0071840,GO:0071944,GO:0080090,GO:0080134,GO:0090034,GO:0097159,GO:1901363,GO:1902882 ko:K18955 ko00000,ko03000 Bacteria 2CC1Y@1,2IQS5@201174,32S23@2,4E4SU@85010 NA|NA|NA K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA MAG.T12.14_01309 1122622.ATWJ01000007_gene1560 5.1e-221 773.9 Intrasporangiaceae groL GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006457,GO:0006458,GO:0006725,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009295,GO:0009408,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016465,GO:0030312,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042026,GO:0042262,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043388,GO:0043590,GO:0044093,GO:0044183,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0050896,GO:0051082,GO:0051098,GO:0051099,GO:0051101,GO:0051716,GO:0061077,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090143,GO:0090304,GO:0097159,GO:0101031,GO:1901360,GO:1901363,GO:1990220,GO:2000677,GO:2000679 ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 Bacteria 2GKC9@201174,4FF25@85021,COG0459@1,COG0459@2 NA|NA|NA O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions MAG.T12.14_01310 1306174.JODP01000006_gene3620 6.1e-40 169.9 Actinobacteria groS GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 ko:K04078 ko00000,ko03029,ko03110 Bacteria 2IKTH@201174,COG0234@1,COG0234@2 NA|NA|NA O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter MAG.T12.14_01311 1157640.AQWO01000012_gene167 1.1e-67 264.2 Actinobacteria Bacteria 2GK97@201174,COG2265@1,COG2265@2 NA|NA|NA J COG0500 SAM-dependent methyltransferases MAG.T12.14_01313 1306174.JODP01000003_gene1895 7e-36 157.5 Actinobacteria Bacteria 2I8Y7@201174,COG2197@1,COG2197@2 NA|NA|NA KT Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain MAG.T12.14_01314 1169161.KB897730_gene1069 3.1e-12 80.9 Actinobacteria Bacteria 2I8JH@201174,COG4585@1,COG4585@2 NA|NA|NA T signal transduction histidine kinase MAG.T12.14_01315 1184609.KILIM_003_00270 3.2e-152 544.7 Dermatophilaceae tsaD GO:0000287,GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140030,GO:0140032,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 ko:K01409,ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 R10648 RC00070,RC00416 ko00000,ko00001,ko00002,ko01000,ko02044,ko03016 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 Bacteria 2GJ98@201174,4F606@85018,COG0533@1,COG0533@2 NA|NA|NA J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction MAG.T12.14_01316 235985.BBPN01000023_gene2700 4.5e-27 127.9 Streptacidiphilus rimI GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008999,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0017189,GO:0018193,GO:0018194,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564 2.3.1.128,2.3.1.234 ko:K01409,ko:K03789,ko:K14742 R10648 RC00070,RC00416 ko00000,ko01000,ko03009,ko03016 Bacteria 2IM9R@201174,2NH04@228398,COG0454@1,COG0456@2 NA|NA|NA K Acetyltransferase (GNAT) domain MAG.T12.14_01317 1449353.JQMQ01000005_gene3688 9.7e-46 190.3 Streptacidiphilus yeaZ GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0071944,GO:0090304,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 ko:K01409,ko:K14742 R10648 RC00070,RC00416 ko00000,ko01000,ko03016 Bacteria 2GMTM@201174,2NF90@228398,COG1214@1,COG1214@2 NA|NA|NA O Glycoprotease family MAG.T12.14_01318 935839.JAGJ01000006_gene3358 5.9e-44 184.1 Promicromonosporaceae ydiB GO:0002949,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.7.1.221,5.1.1.1 ko:K01775,ko:K06925,ko:K07102 ko00473,ko00520,ko01100,ko01502,map00473,map00520,map01100,map01502 R00401,R08968,R11024 RC00002,RC00078,RC00285 ko00000,ko00001,ko01000,ko01011,ko03016 Bacteria 2IKV2@201174,4F4GX@85017,COG0802@1,COG0802@2 NA|NA|NA S Threonylcarbamoyl adenosine biosynthesis protein TsaE MAG.T12.14_01319 479432.Sros_1142 5.3e-82 311.6 Streptosporangiales Bacteria 2GMCK@201174,4EFMQ@85012,COG2267@1,COG2267@2 NA|NA|NA I Serine aminopeptidase, S33 MAG.T12.14_01320 1380346.JNIH01000003_gene2082 1.9e-118 432.6 Actinobacteria alr GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008784,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0019842,GO:0030170,GO:0030203,GO:0034645,GO:0036094,GO:0036361,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0047661,GO:0048037,GO:0050662,GO:0070279,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 R00401 RC00285 ko00000,ko00001,ko01000,ko01011 iEC55989_1330.EC55989_1285,iECIAI39_1322.ECIAI39_1880,iECO103_1326.ECO103_1292,iECO26_1355.ECO26_1703,iECSE_1348.ECSE_1238,iECUMN_1333.ECUMN_1479,iECW_1372.ECW_m1275,iEKO11_1354.EKO11_2666,iEcE24377_1341.EcE24377A_1335,iPC815.YPO0321,iSBO_1134.SBO_4064,iSbBS512_1146.SbBS512_E4542,iWFL_1372.ECW_m1275,iYL1228.KPN_02308,iYL1228.KPN_04440 Bacteria 2GM2Y@201174,COG0787@1,COG0787@2 NA|NA|NA E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids MAG.T12.14_01321 1048339.KB913029_gene2786 1.5e-61 243.8 Frankiales nnrD GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0052855,GO:0052856,GO:0052857 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 ko00000,ko01000 Bacteria 2GJHB@201174,4ERGP@85013,COG0062@1,COG0062@2,COG0063@1,COG0063@2 NA|NA|NA G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration MAG.T12.14_01322 1429046.RR21198_0487 9.6e-74 284.3 Nocardiaceae gcd Bacteria 2GISM@201174,4FYBJ@85025,COG2133@1,COG2133@2 NA|NA|NA G Glucose / Sorbosone dehydrogenase MAG.T12.14_01324 1510531.JQJJ01000008_gene4215 3.4e-156 558.5 Bradyrhizobiaceae ybaL GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03455 ko00000 2.A.37 Bacteria 1MV34@1224,2TRC5@28211,3JVBN@41294,COG1226@1,COG1226@2,COG4651@1,COG4651@2 NA|NA|NA P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family MAG.T12.14_01325 1033730.CAHG01000004_gene3 2.2e-59 235.3 Propionibacteriales adk 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GJ7T@201174,4DP2T@85009,COG0563@1,COG0563@2 NA|NA|NA F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism MAG.T12.14_01326 266940.Krad_1202 8.2e-08 64.3 Bacteria ko:K15383 ko00000,ko02000 9.A.58.2 Bacteria COG4095@1,COG4095@2 NA|NA|NA S Sugar efflux transporter for intercellular exchange MAG.T12.14_01327 1150399.AQYK01000002_gene2758 1.3e-37 162.9 Microbacteriaceae yaeJ ko:K02835,ko:K15034 ko00000,ko03012 Bacteria 2I7Z4@201174,4FPEN@85023,COG0216@1,COG0216@2 NA|NA|NA J RF-1 domain MAG.T12.14_01329 1171373.PACID_04150 3.3e-08 64.3 Propionibacteriales ko:K00375 ko00000,ko03000 Bacteria 2GITW@201174,4DPHM@85009,COG1167@1,COG1167@2 NA|NA|NA K helix_turn_helix gluconate operon transcriptional repressor MAG.T12.14_01330 1157943.KB892705_gene3044 7.9e-51 207.6 Bacteria cof Bacteria COG0561@1,COG0561@2 NA|NA|NA Q phosphatase activity MAG.T12.14_01331 446466.Cfla_3402 2.4e-228 798.1 Cellulomonadaceae gguA 3.6.3.17 ko:K10545,ko:K10548 ko02010,map02010 M00215,M00216 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2.4,3.A.1.2.5 Bacteria 2GJ3F@201174,4F0KB@85016,COG1129@1,COG1129@2 NA|NA|NA G PFAM ABC transporter related MAG.T12.14_01332 446466.Cfla_3403 7.1e-173 613.6 Cellulomonadaceae gguB GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0016020,GO:0016021,GO:0019321,GO:0031224,GO:0042732,GO:0044238,GO:0044281,GO:0044425,GO:0044464,GO:0071704,GO:0071944 ko:K10547 ko02010,map02010 M00216 ko00000,ko00001,ko00002,ko02000 3.A.1.2.5 Bacteria 2GJAH@201174,4F0VZ@85016,COG4214@1,COG4214@2 NA|NA|NA G Belongs to the binding-protein-dependent transport system permease family MAG.T12.14_01333 1120946.AUBF01000012_gene1136 5.8e-144 517.3 Actinobacteria ko:K10546 ko02010,map02010 M00216 ko00000,ko00001,ko00002,ko02000 3.A.1.2.5 Bacteria 2GKRE@201174,4D5CU@85005,COG4213@1,COG4213@2 NA|NA|NA G Periplasmic binding protein domain MAG.T12.14_01334 675635.Psed_6174 2.7e-169 601.7 Pseudonocardiales fadI GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0003988,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005777,GO:0005782,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0031907,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0032787,GO:0034440,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0055114,GO:0070013,GO:0071704,GO:0072329,GO:0097159,GO:1901363,GO:1901575 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GJI8@201174,4DXSK@85010,COG0183@1,COG0183@2 NA|NA|NA I Belongs to the thiolase family MAG.T12.14_01335 590998.Celf_3120 9.1e-79 300.8 Cellulomonadaceae Bacteria 2HNN0@201174,4F0DD@85016,COG0523@1,COG0523@2 NA|NA|NA S PFAM cobalamin synthesis CobW domain protein MAG.T12.14_01336 405948.SACE_1498 7.8e-31 140.2 Pseudonocardiales zur GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010043,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0046872,GO:0046914,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 ko:K02076,ko:K03711,ko:K09823 ko02024,map02024 ko00000,ko00001,ko03000 Bacteria 2IKS3@201174,4E2M3@85010,COG0735@1,COG0735@2 NA|NA|NA P Belongs to the Fur family MAG.T12.14_01337 526225.Gobs_1602 3.8e-61 241.9 Frankiales scbA ko:K09815 ko02010,map02010 M00242 ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 Bacteria 2GM1K@201174,4ET8X@85013,COG0803@1,COG0803@2 NA|NA|NA P Belongs to the bacterial solute-binding protein 9 family MAG.T12.14_01338 1155718.KB891877_gene5380 1e-30 139.0 Actinobacteria Bacteria 2GKDR@201174,COG0523@1,COG0523@2 NA|NA|NA S cobalamin synthesis CobW domain protein MAG.T12.14_01339 1137271.AZUM01000002_gene3043 1.5e-175 623.2 Pseudonocardiales ko:K06994 ko00000 Bacteria 2GIRQ@201174,4DZH4@85010,COG2409@1,COG2409@2 NA|NA|NA S RND superfamily MAG.T12.14_01340 397278.JOJN01000015_gene3488 2.1e-137 495.4 Propionibacteriales galE1 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 Bacteria 2GMCW@201174,4DP83@85009,COG1087@1,COG1087@2 NA|NA|NA M Polysaccharide biosynthesis protein MAG.T12.14_01341 590998.Celf_1150 3.2e-127 461.8 Cellulomonadaceae galK 2.7.1.6,2.7.7.12 ko:K00849,ko:K00965 ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917 M00362,M00554,M00632 R00955,R01092 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GJXI@201174,4F1TD@85016,COG0153@1,COG0153@2 NA|NA|NA G Belongs to the GHMP kinase family. GalK subfamily MAG.T12.14_01342 979556.MTES_2077 4.2e-271 940.6 Microbacteriaceae 3.2.1.22 ko:K07407 ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603 R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091 RC00049,RC00059,RC00451 ko00000,ko00001,ko01000 Bacteria 2GJJ1@201174,4FKWH@85023,COG3345@1,COG3345@2 NA|NA|NA G Melibiase MAG.T12.14_01343 979556.MTES_2076 1e-73 283.9 Actinobacteria ko:K02529 ko00000,ko03000 Bacteria 2GKFC@201174,COG1609@1,COG1609@2 NA|NA|NA K transcriptional regulator MAG.T12.14_01344 208444.JNYY01000016_gene805 3.1e-83 315.5 Pseudonocardiales Bacteria 2GJBJ@201174,4E2I8@85010,COG1609@1,COG1609@2 NA|NA|NA K Bacterial regulatory proteins, lacI family MAG.T12.14_01345 1032480.MLP_11610 4.1e-46 191.8 Actinobacteria Bacteria 2IFGR@201174,COG2865@1,COG2865@2 NA|NA|NA K Putative DNA-binding domain MAG.T12.14_01346 1219065.VPR01S_05_01810 1.1e-47 196.4 Vibrionales lacA 2.3.1.79 ko:K00661 ko00000,ko01000 Bacteria 1RF1T@1224,1S4DA@1236,1XTJQ@135623,COG0110@1,COG0110@2 NA|NA|NA S COG0110 Acetyltransferase (isoleucine patch superfamily) MAG.T12.14_01347 521674.Plim_2873 6.8e-71 275.0 Planctomycetes mmoQ Bacteria 2IZRQ@203682,COG1639@1,COG1639@2,COG2199@1,COG3706@2 NA|NA|NA T signal transduction protein MAG.T12.14_01348 1136417.AZWE01000016_gene64 7.8e-73 281.2 Micromonosporales yibF Bacteria 2GKJ4@201174,4D8GP@85008,COG5438@1,COG5438@2 NA|NA|NA S YibE F family protein MAG.T12.14_01349 446466.Cfla_1918 1e-59 236.9 Actinobacteria ko:K00241 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 Bacteria 28HIR@1,2I860@201174,30UAY@2 NA|NA|NA S succinate dehydrogenase MAG.T12.14_01350 446466.Cfla_1917 0.0 1117.4 Cellulomonadaceae sdhA 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ45@201174,4F0MT@85016,COG1053@1,COG1053@2 NA|NA|NA C PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein MAG.T12.14_01351 446466.Cfla_1916 3.4e-111 407.9 Actinobacteria sdhB 1.3.5.1,1.3.5.4 ko:K00240,ko:K00245 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00149,M00150,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJPS@201174,COG0479@1,COG0479@2 NA|NA|NA C succinate dehydrogenase MAG.T12.14_01352 593907.Celgi_2505 1.1e-155 556.6 Actinobacteria efeN ko:K16301 ko00000,ko01000,ko02000 2.A.108.2.3 Bacteria 2GIUB@201174,COG2837@1,COG2837@2 NA|NA|NA P peroxidase MAG.T12.14_01353 1304865.JAGF01000001_gene176 2.1e-16 91.3 Cellulomonadaceae ycdO GO:0000041,GO:0006810,GO:0006811,GO:0006812,GO:0006826,GO:0008150,GO:0015684,GO:0030001,GO:0051179,GO:0051234,GO:0070838,GO:0072511 ko:K07224 ko00000,ko02000 2.A.108.2.3 Bacteria 2GJPY@201174,4F1P3@85016,COG2822@1,COG2822@2 NA|NA|NA P Imelysin MAG.T12.14_01355 397278.JOJN01000001_gene2592 1.5e-132 480.3 Propionibacteriales pknL 2.7.11.1 ko:K12132 ko00000,ko01000,ko01001 Bacteria 2GJ1J@201174,4DPC3@85009,COG0515@1,COG0515@2,COG2815@1,COG2815@2 NA|NA|NA KLT serine threonine protein kinase MAG.T12.14_01356 479433.Caci_6006 1.8e-68 266.2 Actinobacteria ydeD Bacteria 2I8X5@201174,COG0697@1,COG0697@2 NA|NA|NA EG of the drug metabolite transporter (DMT) superfamily MAG.T12.14_01357 1283283.ATXA01000003_gene1425 3.8e-113 414.8 Frankiales ltaA 4.1.2.48 ko:K01620 ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 R00751,R06171 RC00312,RC00372 ko00000,ko00001,ko01000 Bacteria 2GMNV@201174,4ERZD@85013,COG2008@1,COG2008@2 NA|NA|NA E Beta-eliminating lyase MAG.T12.14_01359 471852.Tcur_2640 1.1e-179 636.3 Streptosporangiales aroH 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJBX@201174,4EGEY@85012,COG3200@1,COG3200@2 NA|NA|NA E Class-II DAHP synthetase family MAG.T12.14_01360 278957.ABEA03000041_gene2097 1.7e-168 599.0 Opitutae pfp 2.7.1.90 ko:K00895 ko00010,ko00030,ko00051,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map01100,map01110,map01120,map01130 R00764,R02073 RC00017 ko00000,ko00001,ko01000 Bacteria 3K75J@414999,46UQV@74201,COG0205@1,COG0205@2 NA|NA|NA H Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions MAG.T12.14_01361 1236902.ANAS01000015_gene578 9e-191 673.3 Streptosporangiales glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 Bacteria 2GM13@201174,4EFI5@85012,COG0554@1,COG0554@2 NA|NA|NA C Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate MAG.T12.14_01362 710696.Intca_1969 8.3e-86 323.6 Intrasporangiaceae plsC 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 2GJ6V@201174,4FEIG@85021,COG0204@1,COG0204@2 NA|NA|NA I 1-acyl-sn-glycerol-3-phosphate acyltransferase MAG.T12.14_01363 1048339.KB913029_gene4594 6.2e-60 237.7 Frankiales yvaK 3.1.1.1 ko:K03928 ko00000,ko01000 Bacteria 2GM1Y@201174,4ETTX@85013,COG1647@1,COG1647@2 NA|NA|NA S Serine aminopeptidase, S33 MAG.T12.14_01364 1896.JOAU01000001_gene4484 9.2e-12 77.4 Actinobacteria Bacteria 2EN8E@1,2GMI1@201174,33FW7@2 NA|NA|NA MAG.T12.14_01366 1122138.AQUZ01000033_gene3595 1.6e-33 149.1 Propionibacteriales Bacteria 2IFH4@201174,4DRBM@85009,COG2867@1,COG2867@2 NA|NA|NA I Polyketide cyclase / dehydrase and lipid transport MAG.T12.14_01367 1306174.JODP01000009_gene6550 2e-24 119.4 Actinobacteria Bacteria 2IBDE@201174,COG2197@1,COG2197@2 NA|NA|NA T Two component transcriptional regulator, luxr family MAG.T12.14_01368 471852.Tcur_2117 1.7e-54 220.3 Streptosporangiales Bacteria 2GN1J@201174,4EJA0@85012,COG5650@1,COG5650@2 NA|NA|NA S Glycosyltransferase family 87 MAG.T12.14_01369 561175.KB894094_gene1431 1.7e-133 482.6 Streptosporangiales pimB 2.4.1.346,3.2.1.8 ko:K01181,ko:K13668 R11703,R11704 ko00000,ko01000,ko01003 GT4 Bacteria 2GM6D@201174,4EHII@85012,COG0438@1,COG0438@2 NA|NA|NA M Glycosyl transferases group 1 MAG.T12.14_01370 1048339.KB913029_gene4617 8e-12 75.9 Actinobacteria Bacteria 2EGHN@1,2GSZ1@201174,33A9R@2 NA|NA|NA MAG.T12.14_01371 196162.Noca_3127 6.6e-21 106.3 Actinobacteria Bacteria 2ES7R@1,2IQ6C@201174,33JSG@2 NA|NA|NA MAG.T12.14_01372 1193181.BN10_360026 3.9e-166 591.7 Intrasporangiaceae cho GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006289,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009380,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016787,GO:0016788,GO:0030312,GO:0031668,GO:0032991,GO:0033554,GO:0033683,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1902494,GO:1905347,GO:1905348,GO:1990391 2.7.7.7 ko:K02342,ko:K03763,ko:K05984 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 2GMC0@201174,4FEF6@85021,COG0322@1,COG0322@2,COG2176@1,COG2176@2 NA|NA|NA L Contains 3'-5'exonuclease domain MAG.T12.14_01373 1504319.GM45_0755 3.2e-194 684.9 unclassified Actinobacteria (class) petD GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009512,GO:0009579,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0040007,GO:0044424,GO:0044425,GO:0044436,GO:0044459,GO:0044464,GO:0070069,GO:0071944 ko:K00412,ko:K02635,ko:K02637,ko:K03887,ko:K03891,ko:K15879 ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152,M00162 ko00000,ko00001,ko00002,ko00194,ko03029 Bacteria 2GJ1E@201174,3UWCW@52018,COG1290@1,COG1290@2 NA|NA|NA C Cytochrome b/b6/petB MAG.T12.14_01374 1504319.GM45_0760 6e-103 380.9 unclassified Actinobacteria (class) qcrA GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K03890,ko:K15878 ko00190,ko01100,map00190,map01100 M00151 ko00000,ko00001,ko00002 iAF987.Gmet_0538 Bacteria 2GIX6@201174,3UWCF@52018,COG0723@1,COG0723@2 NA|NA|NA C Rieske [2Fe-2S] domain MAG.T12.14_01375 1504319.GM45_0765 1.2e-71 276.6 unclassified Actinobacteria (class) qcrC GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K00406,ko:K03889 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00151,M00156 ko00000,ko00001,ko00002 3.D.4.3 Bacteria 2GKUB@201174,3UWHN@52018,COG2010@1,COG2010@2 NA|NA|NA C Cytochrome C oxidase, cbb3-type, subunit III MAG.T12.14_01376 1214101.BN159_6284 3.2e-70 271.6 Actinobacteria ctaE GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 iJN678.ctaE Bacteria 2GKK8@201174,COG1845@1,COG1845@2 NA|NA|NA C cytochrome c oxidase, subunit III MAG.T12.14_01377 196162.Noca_3132 6.1e-46 190.3 Propionibacteriales GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 Bacteria 2II71@201174,4DQR3@85009,COG0784@1,COG0784@2 NA|NA|NA T cheY-homologous receiver domain MAG.T12.14_01378 469371.Tbis_1298 5.1e-92 344.7 Pseudonocardiales trpD 2.4.2.18,4.1.3.27 ko:K00766,ko:K13497 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R00985,R00986,R01073 RC00010,RC00440,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 Bacteria 2GM4G@201174,4DYFX@85010,COG0547@1,COG0547@2 NA|NA|NA E Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) MAG.T12.14_01380 351607.Acel_0958 2.8e-24 118.2 Frankiales ctaF GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 2D9MJ@1,2IFFM@201174,32TTI@2,4ETA5@85013 NA|NA|NA C Belongs to the cytochrome c oxidase bacterial subunit CtaF family MAG.T12.14_01381 446466.Cfla_2081 5.1e-240 837.0 Cellulomonadaceae ctaD GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 Bacteria 2GJHX@201174,4F1WI@85016,COG0843@1,COG0843@2 NA|NA|NA C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B MAG.T12.14_01382 1504319.GM45_0705 5.6e-70 271.2 unclassified Actinobacteria (class) ctaC GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0040007,GO:0042773,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044238,GO:0044281,GO:0044403,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0051704,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 Bacteria 2GNXA@201174,3UWMS@52018,COG1622@1,COG1622@2 NA|NA|NA C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) MAG.T12.14_01383 1394178.AWOO02000084_gene1172 1.8e-90 339.7 Streptosporangiales 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 Bacteria 2GJ2B@201174,4EHSY@85012,COG1104@1,COG1104@2 NA|NA|NA E Beta-eliminating lyase MAG.T12.14_01384 1713.JOFV01000020_gene1360 9.1e-13 79.7 Cellulomonadaceae 2.8.1.7 ko:K04085,ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 Bacteria 2GSF4@201174,4F2Z8@85016,COG0425@1,COG0425@2 NA|NA|NA O Sulfurtransferase TusA MAG.T12.14_01385 367299.JOEE01000004_gene1430 9.1e-66 256.9 Intrasporangiaceae aat 2.3.2.6 ko:K00684 R03813,R11443,R11444 RC00055,RC00064 ko00000,ko01000 Bacteria 2IFT7@201174,4FFYP@85021,COG2360@1,COG2360@2 NA|NA|NA O Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine MAG.T12.14_01386 1123320.KB889675_gene3934 3.1e-128 464.9 Actinobacteria adoK GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004001,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005975,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019200,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032552,GO:0032553,GO:0032554,GO:0032555,GO:0032559,GO:0032560,GO:0032561,GO:0032567,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046390,GO:0046483,GO:0046835,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.15,2.7.1.20 ko:K00852,ko:K00856 ko00030,ko00230,ko01100,map00030,map00230,map01100 R00185,R01051,R02750 RC00002,RC00017 ko00000,ko00001,ko01000 iAF987.Gmet_2683 Bacteria 2GKBG@201174,COG0524@1,COG0524@2 NA|NA|NA G Ribokinase MAG.T12.14_01387 1463855.JOHV01000002_gene2392 1e-49 202.6 Actinobacteria erpA GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009061,GO:0009987,GO:0010467,GO:0015980,GO:0016020,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055114,GO:0071704,GO:0071840,GO:0071944,GO:1901564 ko:K13628,ko:K15724 ko00000,ko03016 Bacteria 2IHR0@201174,COG0316@1,COG0316@2 NA|NA|NA S Belongs to the HesB IscA family MAG.T12.14_01388 1048339.KB913029_gene4641 9.2e-85 320.9 Frankiales glxK GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 2.7.1.165 ko:K00865 ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130 R08572 RC00002,RC00428 ko00000,ko00001,ko01000 Bacteria 2GKHX@201174,4ERQR@85013,COG1929@1,COG1929@2 NA|NA|NA G Belongs to the glycerate kinase type-1 family MAG.T12.14_01389 512565.AMIS_14080 5.9e-174 617.1 Micromonosporales nadA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 Bacteria 2GM59@201174,4D97S@85008,COG0379@1,COG0379@2 NA|NA|NA H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate MAG.T12.14_01390 561175.KB894094_gene1456 8.1e-65 253.4 Streptosporangiales Bacteria 2GP15@201174,31PZA@2,4EIMY@85012,arCOG04740@1 NA|NA|NA MAG.T12.14_01391 749414.SBI_05309 1.2e-102 379.8 Actinobacteria htpX ko:K03799 M00743 ko00000,ko00002,ko01000,ko01002 Bacteria 2GMJF@201174,COG0501@1,COG0501@2 NA|NA|NA O Belongs to the peptidase M48B family MAG.T12.14_01392 929712.KI912613_gene2707 1.6e-28 131.7 Rubrobacteria 2.3.1.15 ko:K08591,ko:K19159 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004,ko02048 Bacteria 2HRW6@201174,4CTZM@84995,COG2161@1,COG2161@2 NA|NA|NA D Antitoxin Phd_YefM, type II toxin-antitoxin system MAG.T12.14_01393 710696.Intca_3501 4e-33 147.1 Intrasporangiaceae ko:K06218 ko00000,ko02048 Bacteria 2GRQR@201174,4FJ7R@85021,COG2026@1,COG2026@2 NA|NA|NA DJ ParE toxin of type II toxin-antitoxin system, parDE MAG.T12.14_01394 1385519.N801_09810 4.2e-164 584.3 Intrasporangiaceae Bacteria 2GS79@201174,4FF88@85021,COG3547@1,COG3547@2 NA|NA|NA L Transposase IS116/IS110/IS902 family MAG.T12.14_01395 1184609.KILIM_005_00340 8.4e-153 547.0 Actinobacteria Bacteria 2GM8F@201174,COG3328@1,COG3328@2 NA|NA|NA L Transposase MAG.T12.14_01396 525368.HMPREF0591_1854 8.8e-100 370.2 Mycobacteriaceae Bacteria 2374G@1762,2I9ZX@201174,COG4974@1,COG4974@2 NA|NA|NA L Belongs to the 'phage' integrase family MAG.T12.14_01397 557599.MKAN_02490 2.7e-213 748.4 Mycobacteriaceae ko:K03733,ko:K04763 ko00000,ko03036 Bacteria 236NP@1762,2IBD6@201174,COG4974@1,COG4974@2 NA|NA|NA L Belongs to the 'phage' integrase family MAG.T12.14_01399 1120944.JONS01000036_gene2549 1.1e-20 105.9 Actinobacteria Bacteria 2GJV7@201174,4D5Q7@85005,COG1609@1,COG1609@2 NA|NA|NA K Periplasmic binding protein domain MAG.T12.14_01401 1123229.AUBC01000025_gene4510 1.8e-19 102.1 Bradyrhizobiaceae Bacteria 1RJ9E@1224,2AF64@1,2U9GE@28211,3154Z@2,3K5A6@41294 NA|NA|NA S Protein of unknown function (DUF2384) MAG.T12.14_01403 1240349.ANGC01000009_gene2758 2.7e-70 272.3 Actinobacteria Bacteria 2ICPM@201174,COG0589@1,COG0589@2 NA|NA|NA T universal stress protein MAG.T12.14_01404 1122149.BACN01000019_gene712 1.7e-07 63.2 Lactobacillaceae greA ko:K03624,ko:K04760 ko00000,ko03021 Bacteria 1V1G3@1239,3F6ZK@33958,4HW8H@91061,COG0782@1,COG0782@2 NA|NA|NA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides MAG.T12.14_01405 644283.Micau_2658 4.6e-128 464.5 Micromonosporales Bacteria 2GRBZ@201174,4DH16@85008,COG3835@1,COG3835@2 NA|NA|NA KT PucR C-terminal helix-turn-helix domain MAG.T12.14_01406 548479.HMPREF0573_10529 2.6e-08 65.5 Actinobacteria 3.6.3.17 ko:K10441 ko02010,map02010 M00212 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 Bacteria 2GJDV@201174,4D5BM@85005,COG1129@1,COG1129@2 NA|NA|NA G ATPases associated with a variety of cellular activities MAG.T12.14_01407 710696.Intca_1166 1.5e-100 372.9 Actinobacteria 2.7.1.15 ko:K00852 ko00030,map00030 R01051,R02750 RC00002,RC00017 ko00000,ko00001,ko01000 Bacteria 2GP1C@201174,COG0524@1,COG0524@2 NA|NA|NA G Belongs to the carbohydrate kinase PfkB family MAG.T12.14_01408 710696.Intca_1165 6.4e-112 410.6 Intrasporangiaceae psuG GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0019200,GO:0044237,GO:0044238,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046835,GO:0071704 4.2.1.70 ko:K16329 ko00240,map00240 R01055 RC00432,RC00433 ko00000,ko00001,ko01000 Bacteria 2GK19@201174,4FEJH@85021,COG2313@1,COG2313@2 NA|NA|NA Q Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway MAG.T12.14_01409 710696.Intca_1164 3.4e-65 255.4 Bacteria Bacteria COG0583@1,COG0583@2 NA|NA|NA K DNA-binding transcription factor activity MAG.T12.14_01411 1095769.CAHF01000025_gene693 2.1e-204 718.4 Oxalobacteraceae gdhA GO:0003674,GO:0003824,GO:0004353,GO:0004354,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.3,1.4.1.4 ko:K00261,ko:K00262 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1MUMF@1224,2VIZ7@28216,472NR@75682,COG0334@1,COG0334@2 NA|NA|NA E Glutamate/Leucine/Phenylalanine/Valine dehydrogenase MAG.T12.14_01412 1232410.KI421412_gene16 3.6e-269 934.5 Desulfuromonadales 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 Bacteria 1N38V@1224,2WKAZ@28221,42MWC@68525,43SUV@69541,COG0574@1,COG0574@2 NA|NA|NA G Pyruvate phosphate dikinase, PEP/pyruvate binding domain MAG.T12.14_01413 1122138.AQUZ01000033_gene3629 2.8e-83 315.8 Propionibacteriales lppS GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016787,GO:0017171,GO:0018104,GO:0019538,GO:0030203,GO:0030312,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044464,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 Bacteria 2GJBA@201174,4DN7Y@85009,COG1376@1,COG1376@2 NA|NA|NA S L,D-transpeptidase catalytic domain MAG.T12.14_01414 1193181.BN10_900020 3e-11 73.9 Intrasporangiaceae fieF Bacteria 2GJ8Q@201174,4FE8E@85021,COG0053@1,COG0053@2 NA|NA|NA P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family MAG.T12.14_01416 926569.ANT_00100 6.7e-55 220.7 Chloroflexi sdpI Bacteria 2G714@200795,COG5658@1,COG5658@2 NA|NA|NA S SdpI/YhfL protein family MAG.T12.14_01417 1429046.RR21198_2521 5.5e-160 570.9 Nocardiaceae Bacteria 2GM4J@201174,4FY11@85025,COG4584@1,COG4584@2 NA|NA|NA L Transposase MAG.T12.14_01418 1268303.RHODMAR_4992 8.8e-38 162.9 Nocardiaceae Bacteria 2H714@201174,4FXQJ@85025,COG1484@1,COG1484@2 NA|NA|NA L IstB-like ATP binding protein MAG.T12.14_01419 101510.RHA1_ro06981 3.7e-165 587.8 Nocardiaceae resD ko:K04763 ko00000,ko03036 Bacteria 2I45W@201174,4G9K9@85025,COG0582@1,COG0582@2 NA|NA|NA L Phage integrase, N-terminal SAM-like domain MAG.T12.14_01420 479431.Namu_1216 1.1e-279 969.1 Actinobacteria Bacteria 2I8Z3@201174,COG0582@1,COG0582@2 NA|NA|NA L integrase family MAG.T12.14_01421 479431.Namu_1217 5.7e-45 187.2 Actinobacteria Bacteria 29RW6@1,2IFWT@201174,30D09@2 NA|NA|NA MAG.T12.14_01422 1157943.KB892705_gene2163 1.5e-62 245.7 Mycobacteriaceae istB Bacteria 234SX@1762,2H714@201174,COG1484@1,COG1484@2 NA|NA|NA L IstB-like ATP binding protein MAG.T12.14_01424 861360.AARI_08090 1.5e-45 189.5 Actinobacteria pin GO:0000150,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140097,GO:1901360 Bacteria 2HSUX@201174,COG1961@1,COG1961@2 NA|NA|NA L Site-specific recombinases, DNA invertase Pin homologs MAG.T12.14_01425 196162.Noca_1085 3.4e-172 611.7 Propionibacteriales modB 2.1.1.72 ko:K00571,ko:K07316 ko00000,ko01000,ko02048 Bacteria 2I8FH@201174,4DTYW@85009,COG2189@1,COG2189@2 NA|NA|NA L DNA methylase MAG.T12.14_01426 1504319.GM45_4930 8.5e-35 152.5 unclassified Actinobacteria (class) sigA ko:K03086 ko00000,ko03021 Bacteria 2GK3Z@201174,3UWCE@52018,COG0568@1,COG0568@2 NA|NA|NA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released MAG.T12.14_01427 1500257.JQNM01000020_gene2569 3.2e-43 181.4 Rhizobiaceae Bacteria 1N7IY@1224,2U993@28211,4BFSP@82115,COG3865@1,COG3865@2 NA|NA|NA S 3-demethylubiquinone-9 3-methyltransferase MAG.T12.14_01428 998088.B565_0889 2.2e-26 125.6 Gammaproteobacteria Bacteria 1RB8R@1224,1S1A6@1236,COG1051@1,COG1051@2 NA|NA|NA F COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes MAG.T12.14_01429 1122130.AUHN01000009_gene584 6.7e-140 504.6 Actinobacteria bglF ko:K02755,ko:K02756,ko:K02757 ko02060,map02060 M00271 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.2.11,4.A.1.2.2,4.A.1.2.5,4.A.1.2.6 Bacteria 2GK6B@201174,COG1263@1,COG1263@2,COG1264@1,COG1264@2,COG2190@1,COG2190@2 NA|NA|NA G Pts system MAG.T12.14_01430 1178540.BA70_17750 1.4e-49 203.4 Bacillus ko:K02538,ko:K03488 ko00000,ko03000 Bacteria 1TQJJ@1239,1ZMHP@1386,4HBB3@91061,COG3711@1,COG3711@2 NA|NA|NA K CAT RNA binding domain MAG.T12.14_01431 1304865.JAGF01000001_gene2261 4.3e-232 810.4 Actinobacteria bglH 3.2.1.86 ko:K01223 ko00010,ko00500,map00010,map00500 R00839,R05133,R05134 RC00049,RC00171,RC00714 ko00000,ko00001,ko01000 GT1 Bacteria 2GJAF@201174,COG2723@1,COG2723@2 NA|NA|NA G Belongs to the glycosyl hydrolase 1 family MAG.T12.14_01432 1304865.JAGF01000001_gene2260 2.7e-229 801.6 Actinobacteria bglF ko:K02755,ko:K02756,ko:K02757 ko02060,map02060 M00271 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.2.11,4.A.1.2.2,4.A.1.2.5,4.A.1.2.6 Bacteria 2GK6B@201174,COG1263@1,COG1263@2,COG1264@1,COG1264@2,COG2190@1,COG2190@2 NA|NA|NA G Pts system MAG.T12.14_01433 446471.Xcel_0116 4.8e-31 141.4 Promicromonosporaceae 5.4.2.12 ko:K15634,ko:K15640 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 Bacteria 2GK2I@201174,4F5AK@85017,COG0406@1,COG0406@2 NA|NA|NA G Phosphoglycerate mutase family MAG.T12.14_01434 1348663.KCH_12620 4.5e-189 667.5 Kitasatospora guaC GO:0003674,GO:0003824,GO:0003920,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0015949,GO:0015950,GO:0015951,GO:0016020,GO:0016491,GO:0016651,GO:0016657,GO:0019637,GO:0019693,GO:0034641,GO:0042802,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.1.1.205,1.7.1.7 ko:K00088,ko:K00364 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R01134,R08240 RC00143,RC00457,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 iEC042_1314.EC042_0103,iECIAI39_1322.ECIAI39_0105,iECUMN_1333.ECUMN_0102 Bacteria 2GNDC@201174,2M0KH@2063,COG0516@1,COG0516@2,COG0517@1,COG0517@2 NA|NA|NA F IMP dehydrogenase / GMP reductase domain MAG.T12.14_01435 882086.SacxiDRAFT_0618 0.0 1189.5 Pseudonocardiales hrpA GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 ko:K03578 ko00000,ko01000 Bacteria 2GIWX@201174,4E02F@85010,COG1643@1,COG1643@2 NA|NA|NA L TIGRFAM ATP-dependent helicase HrpA MAG.T12.14_01437 37919.EP51_31660 4.2e-30 137.9 Nocardiaceae yqgC ko:K09793 ko00000 Bacteria 2IQDE@201174,4G1BR@85025,COG2839@1,COG2839@2 NA|NA|NA S Protein of unknown function (DUF456) MAG.T12.14_01438 446468.Ndas_3308 6.3e-10 69.7 Streptosporangiales Bacteria 2E39Y@1,2GQJA@201174,32Y9G@2,4EKEQ@85012 NA|NA|NA MAG.T12.14_01439 469371.Tbis_2394 1.1e-273 949.1 Pseudonocardiales gyrB2 5.99.1.3 ko:K02470 ko00000,ko01000,ko03032,ko03400 Bacteria 2GM1E@201174,4DZQK@85010,COG0187@1,COG0187@2 NA|NA|NA L PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MAG.T12.14_01440 1504319.GM45_4880 2.8e-51 208.4 unclassified Actinobacteria (class) cah 4.2.1.1 ko:K01673 ko00910,map00910 R00132,R10092 RC02807 ko00000,ko00001,ko01000 Bacteria 2GM1M@201174,3UWU9@52018,COG0288@1,COG0288@2 NA|NA|NA P Carbonic anhydrase MAG.T12.14_01441 66377.JOBH01000015_gene4135 9.9e-111 406.8 Actinobacteria yumC GO:0008150,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0042221,GO:0050896,GO:0051716,GO:0070887,GO:0071241,GO:0071248,GO:0071281 1.18.1.2,1.19.1.1 ko:K21567 ko00000,ko01000 iYO844.BSU32110 Bacteria 2GJ1Z@201174,COG0492@1,COG0492@2 NA|NA|NA C Ferredoxin-NADP reductase MAG.T12.14_01442 561175.KB894100_gene4794 9.3e-44 184.1 Streptosporangiales ko:K07058 ko00000 Bacteria 2GM6P@201174,4EIBQ@85012,COG1295@1,COG1295@2 NA|NA|NA S Virulence factor BrkB MAG.T12.14_01443 1033730.CAHG01000012_gene2363 3.7e-11 73.2 Propionibacteriales Bacteria 2EGJK@1,2GX71@201174,33ABR@2,4DSKZ@85009 NA|NA|NA MAG.T12.14_01445 1077972.ARGLB_050_00040 5e-132 478.4 Micrococcaceae ko:K06883 ko00000 Bacteria 1W8MB@1268,2GJX9@201174,COG0699@1,COG0699@2 NA|NA|NA S Dynamin family MAG.T12.14_01446 1713.JOFV01000005_gene2394 2.9e-91 342.8 Cellulomonadaceae PPA1638 ko:K06883 ko00000 Bacteria 2GM68@201174,4F0FD@85016,COG0699@1,COG0699@2 NA|NA|NA S 50S ribosome-binding GTPase MAG.T12.14_01447 1536773.R70331_22715 2.3e-65 256.1 Paenibacillaceae 1.6.5.5 ko:K00344 ko00000,ko01000 Bacteria 1TZGF@1239,26UA2@186822,4HEDQ@91061,COG0604@1,COG0604@2 NA|NA|NA C Zinc-binding alcohol dehydrogenase MAG.T12.14_01448 512565.AMIS_37850 1.4e-40 172.6 Micromonosporales hsp20 ko:K13993 ko04141,map04141 ko00000,ko00001,ko03110 Bacteria 2IHVJ@201174,4DE8J@85008,COG0071@1,COG0071@2 NA|NA|NA O Belongs to the small heat shock protein (HSP20) family MAG.T12.14_01450 935839.JAGJ01000016_gene2363 2e-38 165.6 Promicromonosporaceae Bacteria 2IM6D@201174,4F4NF@85017,COG4119@1,COG4119@2 NA|NA|NA L NUDIX domain MAG.T12.14_01451 1463825.JNXC01000017_gene6952 2.6e-220 771.9 Pseudonocardiales Bacteria 2GIUI@201174,4DXAD@85010,COG3408@1,COG3408@2 NA|NA|NA G Glycogen debranching enzyme MAG.T12.14_01452 1463825.JNXC01000017_gene6951 1.3e-92 346.7 Pseudonocardiales ko:K00713,ko:K06338 ko00000,ko01000,ko01003,ko01005 Bacteria 2I005@201174,4DXXN@85010,COG0438@1,COG0438@2 NA|NA|NA M PFAM Glycosyl transferases group 1 MAG.T12.14_01453 590998.Celf_3039 4.9e-223 781.6 Actinobacteria Bacteria 2GN7G@201174,COG3291@1,COG3291@2 NA|NA|NA P PFAM PKD domain containing protein MAG.T12.14_01456 994479.GL877880_gene3989 7.1e-61 240.0 Pseudonocardiales gyrB GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 5.99.1.3 ko:K02470 ko00000,ko01000,ko03032,ko03400 Bacteria 2GKGP@201174,4DXBM@85010,COG0187@1,COG0187@2 NA|NA|NA L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner MAG.T12.14_01457 1504319.GM45_6200 0.0 1144.4 unclassified Actinobacteria (class) gyrA GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 5.99.1.3 ko:K02469 ko00000,ko01000,ko03032,ko03400 Bacteria 2GJ2Q@201174,3UWEZ@52018,COG0188@1,COG0188@2 NA|NA|NA L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner MAG.T12.14_01458 1283287.KB822575_gene768 2.2e-21 109.4 Propionibacteriales GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 Bacteria 2GKZP@201174,4DR9G@85009,COG3266@1,COG3266@2 NA|NA|NA S Transmembrane domain of unknown function (DUF3566) MAG.T12.14_01462 1203605.HMPREF1531_01896 3e-63 248.1 Propionibacteriales ppiA GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0030312,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0071704,GO:0071944,GO:0140096,GO:1901564 5.2.1.8 ko:K01802,ko:K03767,ko:K03768 ko01503,ko04217,map01503,map04217 ko00000,ko00001,ko01000,ko03110,ko04147 Bacteria 2IFUE@201174,4DQA4@85009,COG0652@1,COG0652@2 NA|NA|NA O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides MAG.T12.14_01463 1122611.KB903952_gene5829 4.1e-40 171.8 Streptosporangiales gluP 3.4.21.105 ko:K19225 ko00000,ko01000,ko01002 Bacteria 2GJYG@201174,4EH62@85012,COG0705@1,COG0705@2 NA|NA|NA S Rhomboid family MAG.T12.14_01464 2002.JOEQ01000029_gene8208 9.9e-15 85.9 Streptosporangiales crgA Bacteria 2E4NY@1,2HZN4@201174,32ZHR@2,4EKK3@85012 NA|NA|NA D Involved in cell division MAG.T12.14_01465 1193181.BN10_150004 1e-42 180.3 Intrasporangiaceae Bacteria 2GJ9Y@201174,4FFV4@85021,COG3879@1,COG3879@2 NA|NA|NA S Bacterial protein of unknown function (DUF881) MAG.T12.14_01466 1123320.KB889730_gene5990 6e-77 293.9 Actinobacteria trpG GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 2.6.1.85 ko:K01664,ko:K13950 ko00790,map00790 R01716 RC00010,RC01418 ko00000,ko00001,ko01000 Bacteria 2GJUX@201174,COG0512@1,COG0512@2 NA|NA|NA EH Glutamine amidotransferase of anthranilate synthase MAG.T12.14_01467 1463926.JOCA01000003_gene5189 2.6e-123 448.7 Actinobacteria ybdL GO:0003674,GO:0003824,GO:0005488,GO:0008144,GO:0008483,GO:0010326,GO:0016740,GO:0016769,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.6.1.17,2.6.1.88 ko:K14267,ko:K14287 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04475,R08618 RC00006,RC00025 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 2GJ7R@201174,COG0436@1,COG0436@2 NA|NA|NA E Aminotransferase MAG.T12.14_01468 1193181.BN10_800007 3.2e-72 278.5 Intrasporangiaceae ko:K07124 ko00000 Bacteria 2GKJE@201174,4FFCH@85021,COG0300@1,COG0300@2 NA|NA|NA S Belongs to the short-chain dehydrogenases reductases (SDR) family MAG.T12.14_01469 1120936.KB907212_gene5233 1.9e-12 79.3 Streptosporangiales 2.3.1.43 ko:K00650 ko00564,ko04979,map00564,map04979 R02114 RC00037,RC00055 ko00000,ko00001,ko01000 Bacteria 2IAEU@201174,4EQDC@85012,COG1075@1,COG1075@2 NA|NA|NA S acetyltransferases and hydrolases with the alpha beta hydrolase fold MAG.T12.14_01470 1003195.SCAT_3322 1.6e-70 272.3 Actinobacteria pyrE 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 iJN678.umpS Bacteria 2GKUQ@201174,COG0461@1,COG0461@2 NA|NA|NA F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) MAG.T12.14_01471 1179773.BN6_83110 6.7e-71 273.9 Pseudonocardiales dedA ko:K03975 ko00000 Bacteria 2GKGR@201174,4DX3S@85010,COG0586@1,COG0586@2 NA|NA|NA S SNARE associated Golgi protein MAG.T12.14_01472 465515.Mlut_02030 2.8e-71 275.0 Micrococcaceae spoU 2.1.1.185 ko:K03218,ko:K03437 ko00000,ko01000,ko03009,ko03016 Bacteria 1W7E6@1268,2GM1A@201174,COG0566@1,COG0566@2 NA|NA|NA J rRNA methyltransferase MAG.T12.14_01474 1179773.BN6_01060 2.4e-55 221.9 Pseudonocardiales ftn 1.16.3.1,1.16.3.2 ko:K02217,ko:K22336 ko00860,map00860 R00078 RC02758 ko00000,ko00001,ko01000 Bacteria 2IG5S@201174,4E2T6@85010,COG1528@1,COG1528@2 NA|NA|NA P Iron-storage protein MAG.T12.14_01475 66897.DJ64_03950 1.6e-135 490.3 Actinobacteria dnaX GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0042575,GO:0042802,GO:0043170,GO:0043846,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050790,GO:0061695,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 2GJKA@201174,COG2812@1,COG2812@2 NA|NA|NA L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity MAG.T12.14_01476 1120936.KB907212_gene5028 5.5e-88 330.5 Streptosporangiales recR GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 ko:K06187 ko03440,map03440 ko00000,ko00001,ko03400 Bacteria 2GJY0@201174,4EG4M@85012,COG0353@1,COG0353@2 NA|NA|NA L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO MAG.T12.14_01477 44060.JODL01000011_gene1967 3.4e-42 178.3 Actinobacteria Bacteria 299JI@1,2GMZP@201174,2ZWN1@2 NA|NA|NA S Domain of unknown function (DUF5063) MAG.T12.14_01478 479432.Sros_9311 2e-167 595.5 Streptosporangiales ask 1.1.1.3,2.7.2.4 ko:K00928,ko:K12524 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480,R01773,R01775 RC00002,RC00043,RC00087 ko00000,ko00001,ko00002,ko01000 Bacteria 2GN0G@201174,4EG8Z@85012,COG0527@1,COG0527@2 NA|NA|NA E ACT domain MAG.T12.14_01479 593907.Celgi_2847 9e-139 500.0 Cellulomonadaceae asd GO:0003674,GO:0003824,GO:0004073,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv3708c Bacteria 2GJJ8@201174,4F0DR@85016,COG0136@1,COG0136@2 NA|NA|NA E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate MAG.T12.14_01481 1120950.KB892762_gene5503 3.5e-78 298.5 Propionibacteriales ykuE ko:K07098 ko00000 Bacteria 2GJHT@201174,4DNBM@85009,COG1408@1,COG1408@2 NA|NA|NA S Calcineurin-like phosphoesterase MAG.T12.14_01482 1137269.AZWL01000006_gene6602 1.2e-31 142.9 Actinobacteria yqeY ko:K09117 ko00000 Bacteria 2IFFJ@201174,COG1610@1,COG1610@2 NA|NA|NA S GatB YqeY MAG.T12.14_01483 1504319.GM45_3810 1.2e-180 640.2 unclassified Actinobacteria (class) pon1 2.4.1.129,3.4.16.4 ko:K05365,ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 GT51 Bacteria 2GK21@201174,3UW69@52018,COG0744@1,COG0744@2 NA|NA|NA M Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MAG.T12.14_01484 105420.BBPO01000071_gene4045 5.4e-140 504.2 Streptacidiphilus arsA 3.6.3.16 ko:K01551 ko00000,ko01000,ko02000 3.A.19.1,3.A.21.1,3.A.4.1 Bacteria 2GJYN@201174,2NHKM@228398,COG0003@1,COG0003@2 NA|NA|NA D Anion-transporting ATPase MAG.T12.14_01485 653045.Strvi_9002 6.2e-100 370.9 Actinobacteria arsA GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 3.6.3.16 ko:K01551 ko00000,ko01000,ko02000 3.A.19.1,3.A.21.1,3.A.4.1 Bacteria 2GJ0J@201174,COG0003@1,COG0003@2 NA|NA|NA D Pfam Anion-transporting ATPase MAG.T12.14_01486 269800.Tfu_0115 2.2e-42 179.5 Streptosporangiales MA20_36340 Bacteria 2GN6D@201174,4EFJ2@85012,COG0494@1,COG0494@2 NA|NA|NA L NUDIX hydrolase MAG.T12.14_01487 1184607.AUCHE_04_00900 3.3e-48 198.0 Dermatophilaceae Bacteria 2IHNE@201174,4F6ZV@85018,COG0251@1,COG0251@2 NA|NA|NA J Endoribonuclease L-PSP MAG.T12.14_01488 1169154.KB897777_gene3606 3e-17 93.6 Actinobacteria Bacteria 2E3JZ@1,2GQIX@201174,32YI8@2 NA|NA|NA MAG.T12.14_01489 105420.BBPO01000071_gene4051 3.4e-78 298.1 Streptacidiphilus glxR GO:0000166,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010675,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030312,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0032993,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000874,GO:2001141 ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 ko00000,ko00001,ko03000 Bacteria 2GMPN@201174,2NFJS@228398,COG0664@1,COG0664@2 NA|NA|NA T helix_turn_helix, cAMP Regulatory protein MAG.T12.14_01490 351607.Acel_1994 2.2e-26 125.6 Frankiales Bacteria 2AZUF@1,2HU1W@201174,31S3S@2,4EWGK@85013 NA|NA|NA MAG.T12.14_01491 1120950.KB892762_gene5486 1.4e-90 339.3 Propionibacteriales nth GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0030312,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 4.2.99.18 ko:K10773 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 2GJ01@201174,4DNJN@85009,COG0177@1,COG0177@2 NA|NA|NA L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate MAG.T12.14_01492 1120950.KB892762_gene5484 3.3e-62 245.0 Propionibacteriales Bacteria 2GKG9@201174,4DQJF@85009,COG0494@1,COG0494@2 NA|NA|NA L NUDIX domain MAG.T12.14_01493 1122182.KB903835_gene4527 5.4e-47 195.3 Micromonosporales cvpA GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009268,GO:0009405,GO:0009628,GO:0010447,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051704,GO:0071944 Bacteria 2GJ92@201174,4DA7U@85008,COG0265@1,COG0265@2 NA|NA|NA O Peptidase s1 and s6 chymotrypsin hap MAG.T12.14_01494 1123320.KB889692_gene167 1.5e-100 372.9 Actinobacteria Bacteria 2I2IM@201174,COG2267@1,COG2267@2 NA|NA|NA I Alpha beta hydrolase MAG.T12.14_01495 1380356.JNIK01000011_gene1918 3e-13 82.0 Frankiales Bacteria 2DPPE@1,2IN30@201174,332VJ@2,4ETAT@85013 NA|NA|NA S Putative Actinobacterial Holin-X, holin superfamily III MAG.T12.14_01496 1123320.KB889692_gene169 1.3e-105 390.2 Actinobacteria nhaA ko:K03313 ko00000,ko02000 2.A.33.1 Bacteria 2GKIK@201174,COG3004@1,COG3004@2 NA|NA|NA P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons MAG.T12.14_01500 33876.JNXY01000028_gene3328 6.2e-07 62.4 Micromonosporales Bacteria 2BNCX@1,2H4ZP@201174,32H0K@2,4DIXP@85008 NA|NA|NA MAG.T12.14_01502 1394178.AWOO02000082_gene2172 1.9e-18 101.7 Streptosporangiales Bacteria 2GJAR@201174,4EG63@85012,COG2909@1,COG2909@2 NA|NA|NA K AAA ATPase domain MAG.T12.14_01503 1038860.AXAP01000018_gene3103 4e-40 171.0 Bradyrhizobiaceae Bacteria 1RGXV@1224,2U9EH@28211,3JY58@41294,COG5579@1,COG5579@2 NA|NA|NA S Protein of unknown function (DUF1810) MAG.T12.14_01504 1122130.AUHN01000005_gene2450 2.7e-23 116.3 Bacteria 3.2.1.14 ko:K01183 ko00520,ko01100,map00520,map01100 R01206,R02334 RC00467 ko00000,ko00001,ko01000 GH18 Bacteria COG2374@1,COG2374@2,COG4733@1,COG4733@2 NA|NA|NA S cellulase activity MAG.T12.14_01506 315749.Bcer98_2749 5e-150 538.1 Bacillus ptsG GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.1.193,2.7.1.199,2.7.1.208,2.7.1.211 ko:K02755,ko:K02756,ko:K02757,ko:K02778,ko:K02803,ko:K02804,ko:K02809,ko:K02810,ko:K20107,ko:K20108,ko:K20116,ko:K20117,ko:K20118 ko00010,ko00500,ko00520,ko02060,ko05111,map00010,map00500,map00520,map02060,map05111 M00265,M00267,M00269,M00271,M00806,M00809 R00811,R02738,R04111,R05199 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.1,4.A.1.1.11,4.A.1.1.12,4.A.1.1.13,4.A.1.1.14,4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7,4.A.1.1.9,4.A.1.2.1,4.A.1.2.10,4.A.1.2.11,4.A.1.2.12,4.A.1.2.2,4.A.1.2.5,4.A.1.2.6,4.A.1.2.9 Bacteria 1TPJ8@1239,1ZC48@1386,4HA8X@91061,COG1263@1,COG1263@2,COG1264@1,COG1264@2,COG2190@1,COG2190@2 NA|NA|NA G phosphotransferase system MAG.T12.14_01507 1280688.AUJB01000008_gene544 4.5e-48 198.4 Pseudobutyrivibrio ko:K02538 ko00000,ko03000 Bacteria 1TT5A@1239,24931@186801,3NGRF@46205,COG3711@1,COG3711@2 NA|NA|NA K CAT RNA binding domain MAG.T12.14_01508 512565.AMIS_33730 5.3e-09 67.0 Micromonosporales ko:K00375 ko00000,ko03000 Bacteria 2GITW@201174,4D9DH@85008,COG1167@1,COG1167@2 NA|NA|NA K Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs MAG.T12.14_01509 479432.Sros_8876 3.8e-29 136.3 Streptosporangiales hlyD3 ko:K02005,ko:K13888 M00709 ko00000,ko00002,ko02000 8.A.1 Bacteria 2H154@201174,4EGKC@85012,COG0845@1,COG0845@2 NA|NA|NA M HlyD family secretion protein MAG.T12.14_01510 1123320.KB889562_gene6766 9e-82 310.1 Actinobacteria ko:K02003 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GK3I@201174,COG1136@1,COG1136@2 NA|NA|NA V ABC transporter MAG.T12.14_01511 512565.AMIS_48700 3.4e-113 415.2 Micromonosporales macB ko:K02004,ko:K05685 ko02010,map02010 M00258,M00709 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.122.1,3.A.1.122.12 Bacteria 2GIRW@201174,4D8TU@85008,COG0577@1,COG0577@2 NA|NA|NA V MacB-like periplasmic core domain MAG.T12.14_01515 1463845.JOIG01000003_gene4753 3.3e-80 305.1 Actinobacteria ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GKJF@201174,COG0842@1,COG0842@2 NA|NA|NA V transport, permease protein MAG.T12.14_01516 1123322.KB904635_gene2587 1e-110 406.8 Actinobacteria drrA3 ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GIY8@201174,COG1131@1,COG1131@2 NA|NA|NA V ABC transporter MAG.T12.14_01517 1121017.AUFG01000022_gene2176 2.2e-91 342.4 Intrasporangiaceae fieF Bacteria 2GJ8Q@201174,4FE8E@85021,COG0053@1,COG0053@2 NA|NA|NA P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family MAG.T12.14_01519 326424.FRAAL4415 9.9e-56 223.8 Actinobacteria Bacteria 2GIV0@201174,COG0515@1,COG0515@2 NA|NA|NA KLT serine threonine protein kinase MAG.T12.14_01520 644283.Micau_2859 3.6e-189 667.9 Micromonosporales ko:K01436 ko00000,ko01000,ko01002 Bacteria 2I2WA@201174,4DBB4@85008,COG1473@1,COG1473@2 NA|NA|NA S amidohydrolase MAG.T12.14_01521 477641.MODMU_2141 5.8e-48 198.0 Frankiales yybG Bacteria 2GM3W@201174,4EUFF@85013,COG1357@1,COG1357@2 NA|NA|NA S Pentapeptide repeats (8 copies) MAG.T12.14_01522 28444.JODQ01000007_gene5583 1.1e-36 160.2 Streptosporangiales chpE ko:K06600,ko:K06895 ko00000,ko02000,ko02035 2.A.75.1,2.A.76 Bacteria 2INXA@201174,4EPSU@85012,COG1280@1,COG1280@2 NA|NA|NA E LysE type translocator MAG.T12.14_01523 1173264.KI913949_gene3844 8.9e-64 250.8 Oscillatoriales panE 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2643 Bacteria 1G2H9@1117,1H7Y1@1150,COG1893@1,COG1893@2 NA|NA|NA H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid MAG.T12.14_01524 479431.Namu_0492 1.8e-100 372.9 Actinobacteria eutG 1.1.1.1,4.3.3.7 ko:K00001,ko:K01714 ko00010,ko00071,ko00261,ko00300,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,ko01230,map00010,map00071,map00261,map00300,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220,map01230 M00016,M00525,M00526,M00527 R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310,R10147 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273,RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 Bacteria 2IDI8@201174,COG1454@1,COG1454@2 NA|NA|NA C Iron-containing alcohol dehydrogenase MAG.T12.14_01525 479431.Namu_0491 1.3e-30 139.0 Frankiales lsrG 5.3.1.32 ko:K11530 ko02024,map02024 ko00000,ko00001,ko01000 Bacteria 2GSE1@201174,4EX0G@85013,COG1359@1,COG1359@2 NA|NA|NA C Antibiotic biosynthesis monooxygenase MAG.T12.14_01526 1380354.JIAN01000005_gene1271 8.4e-175 620.9 Cellulomonadaceae 3.6.1.27 ko:K19302 ko00550,map00550 R05627 RC00002 ko00000,ko00001,ko01000,ko01011 Bacteria 2GMAV@201174,4F0KN@85016,COG0392@1,COG0392@2 NA|NA|NA S Lysylphosphatidylglycerol synthase TM region MAG.T12.14_01527 1304865.JAGF01000001_gene1621 1.8e-309 1068.1 Cellulomonadaceae pfkA 2.7.1.11,2.7.1.90 ko:K00850,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 Bacteria 2GK6W@201174,4F0UZ@85016,COG0205@1,COG0205@2 NA|NA|NA H Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis MAG.T12.14_01528 644283.Micau_3475 5.2e-25 121.3 Micromonosporales ppaX 3.1.3.18,3.6.1.1 ko:K01091,ko:K06019,ko:K16017 ko00190,ko00630,ko01051,ko01100,ko01110,ko01130,map00190,map00630,map01051,map01100,map01110,map01130 R01334,R06587 RC00017,RC00078 ko00000,ko00001,ko01000 Bacteria 2I9FC@201174,4DFT5@85008,COG0546@1,COG0546@2 NA|NA|NA S HAD-superfamily hydrolase, subfamily IA, variant 3 MAG.T12.14_01530 1035308.AQYY01000001_gene2967 4.1e-25 120.6 Firmicutes Bacteria 1VCZF@1239,COG2329@1,COG2329@2 NA|NA|NA S Antibiotic biosynthesis monooxygenase MAG.T12.14_01533 391037.Sare_1005 1.1e-59 236.1 Micromonosporales bcp GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016020,GO:0016209,GO:0016491,GO:0016667,GO:0016671,GO:0016684,GO:0032843,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0070887,GO:0071944,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 ko:K03564 ko00000,ko01000 iPC815.YPO3064 Bacteria 2IHZ6@201174,4D9TD@85008,COG1225@1,COG1225@2 NA|NA|NA O alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen MAG.T12.14_01535 944547.ABLL_0461 1.1e-12 80.1 Epsilonproteobacteria yjjB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006950,GO:0006970,GO:0008150,GO:0009628,GO:0010033,GO:0010243,GO:0015711,GO:0015740,GO:0015744,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0042221,GO:0042493,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071944,GO:1901652,GO:1901698,GO:1901700 Bacteria 1RAWK@1224,2YNRX@29547,42QRH@68525,COG3610@1,COG3610@2 NA|NA|NA S Threonine/Serine exporter, ThrE MAG.T12.14_01536 1141663.OOC_10266 9.6e-21 107.5 Providencia yjjP GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0008150,GO:0015711,GO:0015740,GO:0015744,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071944 Bacteria 1NH2X@1224,1RN1Q@1236,3Z7GC@586,COG2966@1,COG2966@2 NA|NA|NA S Psort location CytoplasmicMembrane, score MAG.T12.14_01537 1463864.JOGO01000077_gene3331 6.5e-36 156.8 Actinobacteria groS GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 ko:K04078 ko00000,ko03029,ko03110 Bacteria 2IHRC@201174,COG0234@1,COG0234@2 NA|NA|NA O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter MAG.T12.14_01539 1380354.JIAN01000005_gene2705 0.0 1347.0 Cellulomonadaceae lysS GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iAF1260.b4129,iECDH1ME8569_1439.ECDH1ME8569_3989,iECW_1372.ECW_m4490,iEcDH1_1363.EcDH1_3862,iJN678.lysS,iJO1366.b4129,iWFL_1372.ECW_m4490 Bacteria 2GKE0@201174,4F1Q9@85016,COG1190@1,COG1190@2,COG2898@1,COG2898@2 NA|NA|NA J Uncharacterised conserved protein (DUF2156) MAG.T12.14_01542 2045.KR76_02335 6.6e-25 122.9 Propionibacteriales Bacteria 2HQ5S@201174,4DS25@85009,COG4585@1,COG4585@2 NA|NA|NA T Histidine kinase-like ATPases MAG.T12.14_01543 1123377.AUIV01000016_gene295 7.2e-57 228.8 Gammaproteobacteria Bacteria 1R7HC@1224,1T5UV@1236,COG2199@1,COG2202@1,COG2202@2,COG3706@2 NA|NA|NA T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) MAG.T12.14_01544 1120949.KB903294_gene4303 3e-192 678.3 Micromonosporales ko:K03321 ko00000,ko02000 2.A.53.3 Bacteria 2GJCB@201174,4D9U7@85008,COG0659@1,COG0659@2 NA|NA|NA P Sulfate permease family MAG.T12.14_01546 1246995.AFR_22960 2.4e-31 144.8 Micromonosporales 2.7.11.1,3.2.1.4 ko:K01179,ko:K12567 ko00500,ko01100,ko05410,ko05414,map00500,map01100,map05410,map05414 R06200,R11307,R11308 ko00000,ko00001,ko01000,ko01001,ko04131,ko04147,ko04812 GH5,GH9 Bacteria 2H7QD@201174,4DJZF@85008,COG4733@1,COG4733@2 NA|NA|NA NU Fibronectin type III domain MAG.T12.14_01547 710696.Intca_0817 1.7e-106 392.9 Intrasporangiaceae ko:K04088 M00742 ko00000,ko00002,ko01000 Bacteria 2GJ8Q@201174,4FESN@85021,COG0053@1,COG0053@2 NA|NA|NA P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family MAG.T12.14_01548 543632.JOJL01000023_gene1726 3e-30 138.3 Micromonosporales Bacteria 2IJFQ@201174,32SB1@2,4DE0Y@85008,COG1145@1 NA|NA|NA C Ferredoxin MAG.T12.14_01549 1121372.AULK01000001_gene1951 4.8e-98 364.4 Microbacteriaceae uppP 3.6.1.27 ko:K06153 ko00550,map00550 R05627 RC00002 ko00000,ko00001,ko01000,ko01011 Bacteria 2GJVG@201174,4FKPS@85023,COG1968@1,COG1968@2 NA|NA|NA V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin MAG.T12.14_01550 397945.Aave_2022 0.0 1317.8 Comamonadaceae treS GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016310,GO:0034637,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046835,GO:0071704,GO:0071944,GO:1901576 2.4.1.18,2.7.1.175,3.2.1.1,5.4.99.16 ko:K00700,ko:K05343,ko:K16146 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01557,R02108,R02110,R02112,R09945,R11262 RC00002,RC00078,RC01816 ko00000,ko00001,ko00002,ko01000,ko04147 CBM48,GH13 Bacteria 1MVKX@1224,2VHW5@28216,4ABG1@80864,COG0366@1,COG0366@2,COG3281@1,COG3281@2 NA|NA|NA G SMART alpha amylase catalytic sub domain MAG.T12.14_01551 1122622.ATWJ01000008_gene2889 2.3e-207 728.8 Intrasporangiaceae ams 2.4.1.4,3.2.1.1,5.4.99.16 ko:K05341,ko:K05343 ko00500,ko01100,map00500,map01100 R01557,R01823,R02108,R02112,R11262 RC00028,RC01816 ko00000,ko00001,ko01000 GH13 Bacteria 2GKT9@201174,4FEVJ@85021,COG0366@1,COG0366@2 NA|NA|NA G Alpha amylase, catalytic domain MAG.T12.14_01554 1123401.JHYQ01000022_gene1149 1.1e-88 333.2 Gammaproteobacteria XK27_05675 Bacteria 1R6D9@1224,1T0S7@1236,COG0627@1,COG0627@2,COG4947@1,COG4947@2 NA|NA|NA S Putative esterase MAG.T12.14_01555 1299327.I546_5516 6.3e-67 260.8 Mycobacteriaceae 3.8.1.2 ko:K01560 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 R05287 RC00697 ko00000,ko00001,ko01000 Bacteria 23BTU@1762,2IBB1@201174,COG1011@1,COG1011@2 NA|NA|NA S Haloacid dehalogenase-like hydrolase MAG.T12.14_01556 926561.KB900617_gene1274 4.6e-128 464.9 Halanaerobiales scrA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563 2.7.1.211 ko:K02755,ko:K02756,ko:K02757,ko:K02808,ko:K02809,ko:K02810 ko00500,ko02060,map00500,map02060 M00269,M00271 R00811 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.2.1,4.A.1.2.10,4.A.1.2.11,4.A.1.2.12,4.A.1.2.2,4.A.1.2.5,4.A.1.2.6,4.A.1.2.9 iYO844.BSU38050 Bacteria 1TP5X@1239,247WT@186801,3WBUR@53433,COG1263@1,COG1263@2,COG1264@1,COG1264@2 NA|NA|NA G phosphotransferase system, EIIB MAG.T12.14_01557 441769.ABFU01000009_gene2768 2.3e-98 366.3 Bacillus scrB GO:0003674,GO:0003824,GO:0004553,GO:0004564,GO:0005975,GO:0005984,GO:0005985,GO:0005987,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0016052,GO:0016787,GO:0016798,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0046352,GO:0071704,GO:1901575 3.2.1.26 ko:K01193 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00801,R00802,R02410,R03635,R03921,R06088 RC00028,RC00077 ko00000,ko00001,ko01000 GH32 iECSF_1327.ECSF_2568,iYO844.BSU38040 Bacteria 1TPAE@1239,1ZCBA@1386,4H9Y7@91061,COG1621@1,COG1621@2 NA|NA|NA G invertase MAG.T12.14_01558 1380354.JIAN01000008_gene3362 1.1e-31 143.7 Actinobacteria 3.2.1.91 ko:K19668 ko00500,ko01100,ko02020,map00500,map01100,map02020 R02886,R11308 RC00799 ko00000,ko00001,ko01000 GH6 Bacteria 2GN7G@201174,COG3291@1,COG3291@2,COG3420@1,COG3420@2 NA|NA|NA P PFAM PKD domain containing protein MAG.T12.14_01559 590998.Celf_3045 6e-70 271.2 Bacteria 2.4.1.289 ko:K07011,ko:K16870 ko00000,ko01000,ko01003 Bacteria COG1216@1,COG1216@2 NA|NA|NA V Glycosyl transferase, family 2 MAG.T12.14_01560 590998.Celf_3040 3.5e-28 132.1 Bacteria Bacteria 2EFAB@1,33939@2 NA|NA|NA MAG.T12.14_01561 443906.CMM_0825 0.0 1305.0 Microbacteriaceae Bacteria 2GN7G@201174,4FKX3@85023,COG3291@1,COG3291@2 NA|NA|NA G Repeats in polycystic kidney disease 1 (PKD1) and other proteins MAG.T12.14_01562 1150399.AQYK01000002_gene3211 1.6e-71 276.9 Microbacteriaceae Bacteria 2CD7Z@1,2GNGQ@201174,30EQS@2,4FNRW@85023 NA|NA|NA MAG.T12.14_01563 590998.Celf_3032 2.3e-92 346.3 Cellulomonadaceae wcoI 2.7.10.2 ko:K08253,ko:K16692 ko00000,ko01000,ko01001 Bacteria 2GJ1Y@201174,4F2TG@85016,COG0489@1,COG0489@2,COG3944@1,COG3944@2 NA|NA|NA M PFAM lipopolysaccharide biosynthesis protein MAG.T12.14_01564 1121924.ATWH01000001_gene4304 1.2e-118 433.7 Microbacteriaceae gumJ ko:K03328 ko00000 2.A.66.2 Bacteria 2H55P@201174,4FM0V@85023,COG2244@1,COG2244@2 NA|NA|NA M Polysaccharide biosynthesis protein MAG.T12.14_01565 1380354.JIAN01000008_gene3362 1.2e-40 174.5 Actinobacteria 3.2.1.91 ko:K19668 ko00500,ko01100,ko02020,map00500,map01100,map02020 R02886,R11308 RC00799 ko00000,ko00001,ko01000 GH6 Bacteria 2GN7G@201174,COG3291@1,COG3291@2,COG3420@1,COG3420@2 NA|NA|NA P PFAM PKD domain containing protein MAG.T12.14_01566 590998.Celf_3048 2.6e-29 136.3 Actinobacteria rlpA ko:K03642,ko:K03749 ko00000 Bacteria 2I8WA@201174,COG3147@1,COG3147@2 NA|NA|NA N Non-essential cell division protein that could be required for efficient cell constriction MAG.T12.14_01567 31964.CMS2390 9.4e-72 277.3 Microbacteriaceae gumI 2.4.1.251 ko:K13658 R09734 RC00005,RC00049 ko00000,ko01000,ko01003 Bacteria 2IAJJ@201174,4FMGW@85023,COG0438@1,COG0438@2 NA|NA|NA M Glycosyl transferases group 1 MAG.T12.14_01568 1380354.JIAN01000008_gene3362 5.1e-64 252.3 Actinobacteria 3.2.1.91 ko:K19668 ko00500,ko01100,ko02020,map00500,map01100,map02020 R02886,R11308 RC00799 ko00000,ko00001,ko01000 GH6 Bacteria 2GN7G@201174,COG3291@1,COG3291@2,COG3420@1,COG3420@2 NA|NA|NA P PFAM PKD domain containing protein MAG.T12.14_01569 526225.Gobs_0501 6.2e-249 866.7 Frankiales leuA GO:0000287,GO:0003674,GO:0003824,GO:0003852,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0019752,GO:0030145,GO:0030955,GO:0031420,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0046912,GO:0046914,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GISX@201174,4ERVK@85013,COG0119@1,COG0119@2 NA|NA|NA E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) MAG.T12.14_01570 1288083.AUKR01000014_gene2876 3.9e-109 402.5 Actinobacteria Bacteria 2GKI5@201174,COG1835@1,COG1835@2 NA|NA|NA I Acyltransferase MAG.T12.14_01571 469371.Tbis_2812 3.9e-134 484.6 Pseudonocardiales leuB GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044464,GO:0055114 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GK44@201174,4DXBP@85010,COG0473@1,COG0473@2 NA|NA|NA CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate MAG.T12.14_01572 1123322.KB904660_gene1100 1.7e-141 509.2 Actinobacteria ilvE GO:0000082,GO:0000096,GO:0000097,GO:0000278,GO:0003674,GO:0003824,GO:0004084,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0006082,GO:0006464,GO:0006520,GO:0006551,GO:0006555,GO:0006573,GO:0006790,GO:0006807,GO:0007049,GO:0008144,GO:0008150,GO:0008152,GO:0008283,GO:0008483,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009067,GO:0009081,GO:0009082,GO:0009083,GO:0009086,GO:0009098,GO:0009099,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016769,GO:0017144,GO:0018065,GO:0018193,GO:0018205,GO:0018272,GO:0018352,GO:0019538,GO:0019752,GO:0019842,GO:0022402,GO:0030170,GO:0036094,GO:0036211,GO:0040007,GO:0043094,GO:0043102,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044770,GO:0044772,GO:0044843,GO:0046394,GO:0046395,GO:0048037,GO:0050662,GO:0070279,GO:0071265,GO:0071267,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901607,GO:1903047 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 2GKJ1@201174,COG0115@1,COG0115@2 NA|NA|NA E Branched-chain amino acid aminotransferase MAG.T12.14_01573 1155718.KB891889_gene6846 4.3e-204 717.6 Actinobacteria cimA 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GKYT@201174,COG0119@1,COG0119@2 NA|NA|NA E Belongs to the alpha-IPM synthase homocitrate synthase family MAG.T12.14_01574 981369.JQMJ01000004_gene5700 3.4e-82 311.6 Streptacidiphilus fahA Bacteria 2GN2G@201174,2NF0A@228398,COG0179@1,COG0179@2 NA|NA|NA Q Domain of unknown function (DUF2437) MAG.T12.14_01575 1504319.GM45_4290 4.5e-187 661.0 unclassified Actinobacteria (class) gltX GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 iNJ661.Rv2992c Bacteria 2GJJS@201174,3UW9W@52018,COG0008@1,COG0008@2 NA|NA|NA J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) MAG.T12.14_01576 272844.PAB2253 2.7e-33 149.4 Thermococci pgk2 ko:K05715 R02664 RC00002,RC00017 ko00000,ko01000 Archaea 242Y8@183968,2XVZC@28890,COG2074@1,arCOG01967@2157 NA|NA|NA F 2-phosphoglycerate kinase MAG.T12.14_01579 1134445.AJJM01000058_gene2331 1.1e-95 356.3 Actinobacteria ltbR Bacteria 2GKB0@201174,COG1414@1,COG1414@2 NA|NA|NA K transcriptional regulator MAG.T12.14_01583 446471.Xcel_1962 5.1e-57 227.6 Actinobacteria Bacteria 28PII@1,2GTGX@201174,32WVR@2 NA|NA|NA S Protein of unknown function (DUF4255) MAG.T12.14_01585 1146883.BLASA_3175 3.1e-46 191.8 Actinobacteria Bacteria 2GTXG@201174,COG2197@1,COG2197@2 NA|NA|NA K helix_turn_helix, Lux Regulon MAG.T12.14_01586 1283287.KB822582_gene2945 2e-54 219.2 Actinobacteria Bacteria 2I7QR@201174,COG4803@1,COG4803@2 NA|NA|NA S Protein of unknown function (DUF1269) MAG.T12.14_01587 298653.Franean1_6932 2.1e-122 446.0 Frankiales gntK GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0009987,GO:0030312,GO:0044464,GO:0044764,GO:0046812,GO:0051704,GO:0071944 2.3.1.82,2.7.1.12 ko:K00663,ko:K00851,ko:K07028 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 R01737 RC00002,RC00017 ko00000,ko00001,ko01000,ko01504 Bacteria 2GM3U@201174,4EUNB@85013,COG0645@1,COG0645@2,COG2187@1,COG2187@2 NA|NA|NA S AAA domain MAG.T12.14_01589 446471.Xcel_2560 8.2e-76 290.0 Promicromonosporaceae rmlC GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008830,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016853,GO:0016854,GO:0016857,GO:0018130,GO:0019305,GO:0019438,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576 5.1.3.13 ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R06514 RC01531 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv3465 Bacteria 2GMW4@201174,4F3ZC@85017,COG1898@1,COG1898@2 NA|NA|NA M dTDP-4-dehydrorhamnose 3,5-epimerase MAG.T12.14_01590 1121272.KB903283_gene5123 2.3e-36 158.3 Actinobacteria Bacteria 2IIQY@201174,COG1917@1,COG1917@2 NA|NA|NA S Cupin 2, conserved barrel domain protein MAG.T12.14_01591 1463858.JOHR01000009_gene3366 2.5e-97 362.1 Actinobacteria rmlD GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008831,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019305,GO:0019438,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 Bacteria 2GNY8@201174,COG1091@1,COG1091@2 NA|NA|NA M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose MAG.T12.14_01592 43354.JOIJ01000013_gene689 1.3e-142 512.7 Pseudonocardiales rfbB 4.2.1.46,4.2.1.76 ko:K01710,ko:K12450 ko00520,ko00521,ko00523,ko00525,ko01055,ko01130,map00520,map00521,map00523,map00525,map01055,map01130 M00793 R00293,R06513 RC00402 ko00000,ko00001,ko00002,ko01000 Bacteria 2GNDU@201174,4E023@85010,COG1088@1,COG1088@2 NA|NA|NA M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily MAG.T12.14_01593 1380393.JHVP01000002_gene1670 1.5e-115 422.5 Frankiales rfbA GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0005996,GO:0006006,GO:0006139,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008879,GO:0009058,GO:0009059,GO:0009117,GO:0009141,GO:0009147,GO:0009200,GO:0009211,GO:0009219,GO:0009225,GO:0009226,GO:0009262,GO:0009394,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019299,GO:0019300,GO:0019305,GO:0019318,GO:0019319,GO:0019438,GO:0019637,GO:0019692,GO:0030312,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0045226,GO:0046075,GO:0046364,GO:0046379,GO:0046383,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv0334 Bacteria 2GP20@201174,4ETV6@85013,COG1209@1,COG1209@2 NA|NA|NA M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis MAG.T12.14_01594 266940.Krad_0491 5.4e-127 461.5 Actinobacteria slpD Bacteria 2GJYS@201174,COG0596@1,COG0596@2 NA|NA|NA NU Alpha beta hydrolase MAG.T12.14_01596 479435.Kfla_0588 1.3e-99 370.2 Propionibacteriales holB GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 2GJ8C@201174,4DNVR@85009,COG0470@1,COG0470@2 NA|NA|NA L DNA polymerase III MAG.T12.14_01597 1463821.JOGR01000017_gene704 1.9e-50 206.1 Glycomycetales tmk GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 2GNTI@201174,4EXSD@85014,COG0125@1,COG0125@2,COG2211@1,COG2211@2 NA|NA|NA FG Thymidylate kinase MAG.T12.14_01598 1123322.KB904713_gene5176 1.8e-285 988.8 Actinobacteria topA GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009892,GO:0010605,GO:0016020,GO:0016853,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0040007,GO:0043086,GO:0043167,GO:0043169,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060700,GO:0060701,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0140097 5.99.1.2 ko:K03168 ko00000,ko01000,ko03032,ko03400 Bacteria 2GJU7@201174,COG0550@1,COG0550@2,COG1754@1,COG1754@2 NA|NA|NA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone MAG.T12.14_01599 1123320.KB889585_gene1745 8.6e-90 337.8 Actinobacteria rsmC ko:K00612 ko00000,ko01000 Bacteria 2GJPP@201174,COG2890@1,COG2890@2 NA|NA|NA J methyltransferase MAG.T12.14_01600 2002.JOEQ01000018_gene7693 2.2e-268 931.8 Streptosporangiales hppA 3.6.1.1 ko:K15987 ko00190,map00190 ko00000,ko00001,ko01000 3.A.10.1 Bacteria 2GN8B@201174,4EGGE@85012,COG3808@1,COG3808@2 NA|NA|NA C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force MAG.T12.14_01601 47716.JOFH01000021_gene4179 4e-15 87.8 Actinobacteria 2.7.11.1 ko:K04757 ko00000,ko01000,ko01001,ko03021 Bacteria 2IHNR@201174,COG2172@1,COG2172@2 NA|NA|NA T anti-sigma regulatory factor MAG.T12.14_01602 106370.Francci3_4302 9.3e-21 106.3 Frankiales rsbV GO:0003674,GO:0005488,GO:0005515,GO:0042802 ko:K04749 ko00000,ko03021 Bacteria 2IHQG@201174,4ESTZ@85013,COG1366@1,COG1366@2 NA|NA|NA T Belongs to the anti-sigma-factor antagonist family MAG.T12.14_01603 397278.JOJN01000002_gene505 1.5e-227 796.2 Propionibacteriales yprA GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 ko:K06877 ko00000 Bacteria 2GJJ6@201174,4DNQG@85009,COG1205@1,COG1205@2 NA|NA|NA L Domain of unknown function (DUF1998) MAG.T12.14_01605 28444.JODQ01000014_gene6780 1.2e-11 76.3 Streptosporangiales GO:0008150,GO:0010941,GO:0033668,GO:0035821,GO:0042981,GO:0043067,GO:0043069,GO:0044003,GO:0044068,GO:0044403,GO:0044419,GO:0044531,GO:0044532,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051701,GO:0051704,GO:0051817,GO:0052040,GO:0052041,GO:0052150,GO:0052248,GO:0052433,GO:0052490,GO:0060548,GO:0065007 Bacteria 2EGB2@1,2GWPQ@201174,33A2X@2,4EKNC@85012 NA|NA|NA MAG.T12.14_01607 2002.JOEQ01000043_gene5988 5.7e-26 124.8 Streptosporangiales gspF ko:K12510,ko:K12511 ko00000,ko02044 Bacteria 2IQE9@201174,4EJVY@85012,COG2064@1,COG2064@2 NA|NA|NA NU Type II secretion system (T2SS), protein F MAG.T12.14_01608 479432.Sros_0481 3.1e-23 115.5 Streptosporangiales ko:K12510 ko00000,ko02044 Bacteria 2I8NR@201174,4EJYE@85012,COG4965@1,COG4965@2 NA|NA|NA U Type II secretion system (T2SS), protein F MAG.T12.14_01609 1123320.KB889692_gene178 2e-110 406.0 Actinobacteria cpaF ko:K02283 ko00000,ko02035,ko02044 Bacteria 2GKKJ@201174,COG4962@1,COG4962@2 NA|NA|NA U Type ii secretion system protein e MAG.T12.14_01610 1077972.ARGLB_008_01400 2.1e-20 106.7 Micrococcaceae cpaE GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 ko:K04562 ko00000,ko02035 Bacteria 1W9WT@1268,2GIVN@201174,COG0455@1,COG0455@2 NA|NA|NA D bacterial-type flagellum organization MAG.T12.14_01611 570268.ANBB01000058_gene4298 3.8e-44 185.3 Streptosporangiales Bacteria 2GIT8@201174,4EG60@85012,COG3177@1,COG3177@2 NA|NA|NA S Filamentation induced by cAMP protein fic MAG.T12.14_01612 405948.SACE_0337 1.8e-19 101.3 Pseudonocardiales acsA 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 2GJCG@201174,4DXD0@85010,COG0365@1,COG0365@2 NA|NA|NA I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA MAG.T12.14_01613 134676.ACPL_6719 1.3e-45 190.7 Actinobacteria ko:K14645 ko02024,map02024 ko00000,ko00001,ko01000,ko01002,ko03110 Bacteria 2GIRE@201174,COG1404@1,COG1404@2 NA|NA|NA O Belongs to the peptidase S8 family MAG.T12.14_01614 1236902.ANAS01000037_gene5376 5.2e-59 234.6 Streptosporangiales glpQ2 3.1.4.46 ko:K01126 ko00564,map00564 R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 Bacteria 2GJ5W@201174,4EIE7@85012,COG0584@1,COG0584@2 NA|NA|NA C Glycerophosphoryl diester phosphodiesterase family MAG.T12.14_01615 1288494.EBAPG3_12090 4.4e-15 89.0 Nitrosomonadales Bacteria 1PWB7@1224,2BTJW@1,2WBVY@28216,32NSK@2,373WE@32003 NA|NA|NA MAG.T12.14_01616 479433.Caci_5317 7.8e-34 149.8 Actinobacteria rbpA GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 Bacteria 2CNY9@1,2I80U@201174,31DSU@2 NA|NA|NA K RNA polymerase-binding protein MAG.T12.14_01618 452652.KSE_45450 2.4e-97 362.1 Kitasatospora dpm1 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 R01009 RC00005 ko00000,ko00001,ko01000,ko01003 GT2 Bacteria 2I2FA@201174,2M0M1@2063,COG1216@1,COG1216@2 NA|NA|NA S Glycosyltransferase like family 2 MAG.T12.14_01619 561175.KB894096_gene668 8.6e-112 411.0 Streptosporangiales lnt ko:K03820 ko00000,ko01000 GT2 Bacteria 2GJ9F@201174,4EHTJ@85012,COG0815@1,COG0815@2 NA|NA|NA M Transfers the fatty acyl group on membrane lipoproteins MAG.T12.14_01620 1120934.KB894404_gene715 2e-44 185.3 Pseudonocardiales 4.3.1.14 ko:K18014 ko00310,map00310 R03030 RC00833 ko00000,ko00001,ko01000 Bacteria 2IKM2@201174,4E3PP@85010,COG1607@1,COG1607@2 NA|NA|NA I Thioesterase superfamily MAG.T12.14_01621 1122609.AUGT01000003_gene2193 1.3e-94 352.8 Propionibacteriales kamE 5.4.3.3,5.4.3.5 ko:K17898,ko:K18011 ko00310,ko00472,map00310,map00472 R02461,R02852,R03275 RC00719 ko00000,ko00001,ko01000 Bacteria 2HF50@201174,4DNBN@85009,COG2185@1,COG2185@2 NA|NA|NA I Dimerisation domain of d-ornithine 4,5-aminomutase MAG.T12.14_01622 1120950.KB892708_gene4481 1.2e-222 779.2 Propionibacteriales deoC GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 4.1.2.4,5.4.3.3 ko:K01619,ko:K01844 ko00030,ko00310,map00030,map00310 R01066,R02852,R03275 RC00436,RC00437,RC00719 ko00000,ko00001,ko01000 Bacteria 2GUM7@201174,4DNH2@85009,COG0274@1,COG0274@2 NA|NA|NA F D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit MAG.T12.14_01623 1463856.JOHY01000016_gene5622 1.3e-152 546.6 Actinobacteria ytcJ Bacteria 2GJVW@201174,COG1574@1,COG1574@2 NA|NA|NA E amidohydrolase MAG.T12.14_01624 219305.MCAG_00044 4.2e-123 448.0 Micromonosporales kdd 1.4.1.11 ko:K18012 ko00310,map00310 R03349 RC00888 ko00000,ko00001,ko01000 Bacteria 2GK3U@201174,4DA07@85008,COG1063@1,COG1063@2 NA|NA|NA E Dehydrogenase MAG.T12.14_01625 1298863.AUEP01000008_gene1335 2.6e-197 694.9 Propionibacteriales kamA1 5.4.3.2 ko:K01843 ko00310,map00310 R00461 RC00303 ko00000,ko00001,ko01000 Bacteria 2GM2P@201174,4DP5B@85009,COG1509@1,COG1509@2 NA|NA|NA E lysine 2,3-aminomutase MAG.T12.14_01626 1896.JOAU01000013_gene1986 2.7e-52 211.5 Actinobacteria lrp_3 ko:K03719 ko00000,ko03000,ko03036 Bacteria 2GK3G@201174,COG1522@1,COG1522@2 NA|NA|NA K asnC family MAG.T12.14_01627 436229.JOEH01000002_gene3343 2.4e-132 478.8 Streptacidiphilus acdA ko:K18244 ko00000,ko01000 Bacteria 2GIX8@201174,2NHRD@228398,COG1960@1,COG1960@2 NA|NA|NA I Acyl-CoA dehydrogenase, C-terminal domain MAG.T12.14_01628 266940.Krad_1887 4.1e-87 328.2 Actinobacteria polA GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 Bacteria 2GKTZ@201174,COG0258@1,COG0258@2 NA|NA|NA L 5'-3' exonuclease MAG.T12.14_01630 1123322.KB904647_gene1742 6.3e-301 1040.0 Actinobacteria helY GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575 ko:K03727 ko00000,ko01000 Bacteria 2GJEX@201174,COG4581@1,COG4581@2 NA|NA|NA L DEAD DEAH box helicase MAG.T12.14_01631 1121272.KB903257_gene5486 3.3e-65 255.4 Micromonosporales dagK GO:0003674,GO:0003824,GO:0004143,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.1.107 ko:K07029 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 R02240 RC00002,RC00017 ko00000,ko00001,ko01000 Bacteria 2GK3P@201174,4D9SI@85008,COG1597@1,COG1597@2 NA|NA|NA I Diacylglycerol kinase MAG.T12.14_01632 1504319.GM45_0890 2.8e-63 248.8 unclassified Actinobacteria (class) tatC GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 ko:K03118 ko03060,ko03070,map03060,map03070 M00336 ko00000,ko00001,ko00002,ko02044 2.A.64 Bacteria 2GJK8@201174,3UWSI@52018,COG0805@1,COG0805@2 NA|NA|NA U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides MAG.T12.14_01633 106370.Francci3_2305 6.1e-12 76.6 Frankiales tatA ko:K03116 ko03060,ko03070,map03060,map03070 M00336 ko00000,ko00001,ko00002,ko02044 2.A.64 Bacteria 2GQQX@201174,4ETM8@85013,COG1826@1,COG1826@2 NA|NA|NA U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system MAG.T12.14_01634 266940.Krad_1881 1.4e-16 92.4 Actinobacteria Bacteria 2BZPH@1,2IQ4A@201174,33EX8@2 NA|NA|NA MAG.T12.14_01635 1236902.ANAS01000037_gene5402 6.8e-87 328.6 Streptosporangiales pafB GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 ko:K13572,ko:K13573 ko00000,ko03051 Bacteria 2GM46@201174,4EFRP@85012,COG2378@1,COG2378@2 NA|NA|NA K WYL domain MAG.T12.14_01636 1150599.MPHLEI_21374 1.9e-43 181.8 Mycobacteriaceae fkb 5.2.1.8 ko:K01802,ko:K03772 ko00000,ko01000,ko03110 Bacteria 239F5@1762,2IHQC@201174,COG0545@1,COG0545@2 NA|NA|NA O Peptidyl-prolyl cis-trans isomerase MAG.T12.14_01637 1229780.BN381_350110 1.5e-27 129.8 unclassified Actinobacteria (class) Bacteria 2IHQC@201174,3UWVE@52018,COG0545@1,COG0545@2 NA|NA|NA O FKBP-type peptidyl-prolyl cis-trans isomerase MAG.T12.14_01638 1123320.KB889667_gene2950 1.1e-197 696.0 Actinobacteria pafA GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170 6.3.1.19 ko:K13571 M00342 R11207 RC00090,RC00096 ko00000,ko00002,ko01000,ko03051 Bacteria 2GMC6@201174,COG0638@1,COG0638@2 NA|NA|NA O Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine MAG.T12.14_01639 1184609.KILIM_006_00080 1.1e-79 303.1 Dermatophilaceae prcA GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019773,GO:0019941,GO:0030163,GO:0030312,GO:0032991,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 ko:K03432 ko03050,map03050 M00342,M00343 ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 Bacteria 2GKZ1@201174,4F6S2@85018,COG0638@1,COG0638@2 NA|NA|NA O Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation MAG.T12.14_01640 479435.Kfla_3226 6.5e-95 354.0 Propionibacteriales prcB GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019774,GO:0019899,GO:0019941,GO:0030163,GO:0032991,GO:0035375,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 ko:K03433 ko03050,map03050 M00342,M00343 ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 Bacteria 2GJ60@201174,4DPD6@85009,COG0638@1,COG0638@2 NA|NA|NA O Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation MAG.T12.14_01641 446466.Cfla_2002 1e-09 68.9 Cellulomonadaceae pup GO:0003674,GO:0005488,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0031386,GO:0032446,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044877,GO:0051603,GO:0070490,GO:0070628,GO:0070647,GO:0071704,GO:1901564,GO:1901565,GO:1901575 ko:K13570 ko00000,ko04121 Bacteria 2E9C2@1,2I1D6@201174,333JS@2,4F1MQ@85016 NA|NA|NA S Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation MAG.T12.14_01642 469371.Tbis_1836 3.3e-166 591.7 Pseudonocardiales dop GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.5.1.119,6.3.1.19 ko:K13571,ko:K20814 M00342 R11207 RC00090,RC00096 ko00000,ko00002,ko01000,ko03051 Bacteria 2GJGI@201174,4DZ25@85010,COG4122@1,COG4122@2 NA|NA|NA S proteasome accessory factor PafA2 MAG.T12.14_01643 1205680.CAKO01000002_gene2132 4.3e-20 104.4 Rhodospirillales Bacteria 1MZR5@1224,2JU1E@204441,2UCIB@28211,COG3339@1,COG3339@2 NA|NA|NA S Protein of unknown function (DUF1232) MAG.T12.14_01644 1172188.KB911820_gene2155 6.7e-12 77.4 Actinobacteria Bacteria 2B2RZ@1,2GVDD@201174,31VC7@2 NA|NA|NA MAG.T12.14_01645 1394178.AWOO02000005_gene3638 0.0 1547.3 Streptosporangiales gdhB GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016638,GO:0016639,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 R00243 RC00006,RC02799 ko00000,ko00001,ko01000 Bacteria 2GK0C@201174,4EGYX@85012,COG2902@1,COG2902@2 NA|NA|NA E Bacterial NAD-glutamate dehydrogenase MAG.T12.14_01646 1385518.N798_16970 4.7e-21 107.8 Intrasporangiaceae Bacteria 2GS2W@201174,4FGK2@85021,COG3832@1,COG3832@2 NA|NA|NA S Protein of unknown function (DUF2505) MAG.T12.14_01647 1380370.JIBA01000014_gene2099 6.5e-18 97.4 Intrasporangiaceae Bacteria 2GS2W@201174,4FGK2@85021,COG3832@1,COG3832@2 NA|NA|NA S Protein of unknown function (DUF2505) MAG.T12.14_01649 479433.Caci_7582 6.8e-75 287.7 Actinobacteria ko:K07001 ko00000 Bacteria 2IB0F@201174,COG1752@1,COG1752@2 NA|NA|NA S esterase of the alpha-beta hydrolase superfamily MAG.T12.14_01650 1120950.KB892764_gene5614 3.8e-156 558.1 Propionibacteriales tgs3 GO:0000302,GO:0001666,GO:0003674,GO:0003824,GO:0004144,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0006638,GO:0006639,GO:0006641,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019432,GO:0030312,GO:0036293,GO:0040007,GO:0042221,GO:0042493,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0044464,GO:0045017,GO:0046460,GO:0046463,GO:0046486,GO:0047196,GO:0050896,GO:0051704,GO:0070482,GO:0071704,GO:0071731,GO:0071944,GO:0097366,GO:1901576,GO:1901698,GO:1901700 2.3.1.20 ko:K00635 ko00561,ko01100,map00561,map01100 M00089 R02251 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 Bacteria 2HEFF@201174,4DN7F@85009,COG1020@1,COG1020@2 NA|NA|NA Q Belongs to the long-chain O-acyltransferase family MAG.T12.14_01654 358823.DF19_29430 1.5e-28 132.1 Actinobacteria Bacteria 2IQ8I@201174,COG1695@1,COG1695@2 NA|NA|NA K Transcriptional regulator PadR family protein MAG.T12.14_01655 1122611.KB903941_gene2200 3.3e-15 87.8 Actinobacteria Bacteria 2IQ8I@201174,COG1695@1,COG1695@2 NA|NA|NA K Transcriptional regulator PadR family protein MAG.T12.14_01657 1449069.JMLO01000008_gene3545 3.4e-20 105.9 Nocardiaceae Bacteria 2IAVM@201174,4G8K9@85025,COG0596@1,COG0596@2 NA|NA|NA S Alpha/beta hydrolase family MAG.T12.14_01659 1306174.JODP01000015_gene3952 1.7e-149 536.2 Actinobacteria Bacteria 2IBIG@201174,COG0477@1,COG0477@2 NA|NA|NA EGP Major facilitator superfamily MAG.T12.14_01660 208439.AJAP_30840 1.2e-28 134.4 Pseudonocardiales Bacteria 2H2HE@201174,4E9WQ@85010,COG2199@1,COG3706@2 NA|NA|NA T diguanylate cyclase MAG.T12.14_01661 1120949.KB903317_gene1657 2.1e-54 220.3 Micromonosporales ko:K14645 ko02024,map02024 ko00000,ko00001,ko01000,ko01002,ko03110 Bacteria 2GIRE@201174,4DAEM@85008,COG1404@1,COG1404@2 NA|NA|NA O Belongs to the peptidase S8 family MAG.T12.14_01662 1033730.CAHG01000006_gene1155 6.4e-19 99.8 Propionibacteriales ko:K07213 ko04978,map04978 ko00000,ko00001 Bacteria 2GQK5@201174,4DSND@85009,COG2608@1,COG2608@2 NA|NA|NA P Heavy-metal-associated domain MAG.T12.14_01663 1440053.JOEI01000024_gene1194 4e-99 368.6 Actinobacteria dinF GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03327 ko00000,ko02000 2.A.66.1 Bacteria 2GJE3@201174,COG0534@1,COG0534@2 NA|NA|NA V MATE efflux family protein MAG.T12.14_01664 479433.Caci_0301 2.8e-21 107.5 Actinobacteria bldC Bacteria 2GQJ9@201174,COG2452@1,COG2452@2 NA|NA|NA L TIGRFAM DNA binding domain protein, excisionase family MAG.T12.14_01665 1121272.KB903261_gene6014 2e-08 64.7 Micromonosporales Bacteria 2EGRW@1,2IQF3@201174,33AI2@2,4DFQ7@85008 NA|NA|NA S Protein of unknown function (DUF3073) MAG.T12.14_01666 1288083.AUKR01000017_gene2494 6.3e-130 470.7 Actinobacteria purM GO:0003674,GO:0003824,GO:0004641,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.1,6.3.4.13 ko:K01933,ko:K11788 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144,R04208 RC00090,RC00166,RC01100 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1844,iECSF_1327.ECSF_2340 Bacteria 2GJNY@201174,COG0150@1,COG0150@2 NA|NA|NA F Phosphoribosylformylglycinamidine cyclo-ligase MAG.T12.14_01667 479432.Sros_8991 1.9e-203 715.3 Streptosporangiales purF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009507,GO:0009536,GO:0040007,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 Bacteria 2GK6I@201174,4EGDA@85012,COG0034@1,COG0034@2 NA|NA|NA F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine MAG.T12.14_01668 1122602.ATXP01000017_gene2260 3.8e-26 124.4 Micrococcaceae Bacteria 1W9SC@1268,2IQBF@201174,COG3255@1,COG3255@2 NA|NA|NA I Sterol carrier protein MAG.T12.14_01669 1120948.KB903217_gene1248 9.4e-48 196.8 Pseudonocardiales Bacteria 2II0D@201174,4E47X@85010,COG4430@1,COG4430@2 NA|NA|NA S Bacteriocin-protection, YdeI or OmpD-Associated MAG.T12.14_01670 68570.DC74_4016 0.0 1122.5 Actinobacteria purL GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKG6@201174,COG0046@1,COG0046@2 NA|NA|NA F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL MAG.T12.14_01671 452652.KSE_38460 5.3e-98 364.0 Kitasatospora purQ GO:0003674,GO:0003824,GO:0004642,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 Bacteria 2GMJY@201174,2M20R@2063,COG0047@1,COG0047@2 NA|NA|NA F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL MAG.T12.14_01672 653045.Strvi_0527 7e-21 106.7 Actinobacteria purS 6.3.2.6,6.3.5.3 ko:K01923,ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463,R04591 RC00010,RC00064,RC00162,RC01160 ko00000,ko00001,ko00002,ko01000 iYO844.BSU06460 Bacteria 2GQV4@201174,COG1828@1,COG1828@2 NA|NA|NA F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL MAG.T12.14_01673 710685.MycrhN_3684 1.7e-33 149.4 Mycobacteriaceae Bacteria 232CS@1762,28JRZ@1,2H9EF@201174,2Z9HI@2 NA|NA|NA S Domain of unknown function (DUF4126) MAG.T12.14_01674 1120950.KB892759_gene6261 6.3e-67 261.2 Propionibacteriales lytR2 Bacteria 2GJJJ@201174,4DPY2@85009,COG1316@1,COG1316@2 NA|NA|NA K Cell envelope-related transcriptional attenuator domain MAG.T12.14_01676 1169154.KB897784_gene4300 2.3e-51 209.5 Actinobacteria Bacteria 2GKX5@201174,COG0457@1,COG0457@2 NA|NA|NA A Belongs to the DEAD box helicase family MAG.T12.14_01677 452652.KSE_57300 2.2e-79 302.8 Kitasatospora yutF GO:0000121,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009395,GO:0009987,GO:0016042,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0030145,GO:0042578,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0046434,GO:0046475,GO:0046486,GO:0046503,GO:0046872,GO:0046914,GO:0046983,GO:0050897,GO:0071704,GO:1901575 3.1.3.41 ko:K01101 ko00627,ko01120,map00627,map01120 R03024 RC00151 ko00000,ko00001,ko01000 Bacteria 2GK7V@201174,2M1NB@2063,COG0647@1,COG0647@2 NA|NA|NA G Haloacid dehalogenase-like hydrolase MAG.T12.14_01680 479433.Caci_5431 4.7e-87 327.8 Actinobacteria tlyA GO:0000154,GO:0001510,GO:0001897,GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019835,GO:0019836,GO:0022613,GO:0031167,GO:0031640,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035821,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044003,GO:0044004,GO:0044085,GO:0044179,GO:0044237,GO:0044238,GO:0044260,GO:0044364,GO:0044403,GO:0044419,GO:0044764,GO:0046483,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.226,2.1.1.227 ko:K06442 ko00000,ko01000,ko03009 Bacteria 2GJVT@201174,COG1189@1,COG1189@2 NA|NA|NA J Ribosomal RNA methyltransferase RrmJ FtsJ MAG.T12.14_01681 1048339.KB913029_gene4067 4.8e-96 357.8 Frankiales nadK GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0006082,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006793,GO:0006796,GO:0006797,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 R00104 RC00002,RC00078 ko00000,ko00001,ko01000 Bacteria 2GKM2@201174,4ERHI@85013,COG0061@1,COG0061@2 NA|NA|NA G Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP MAG.T12.14_01682 66875.JODY01000020_gene275 6.2e-132 478.0 Actinobacteria recN GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0030312,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:1901360 ko:K03631,ko:K13582 ko04112,map04112 ko00000,ko00001,ko03400 Bacteria 2GIVG@201174,COG0497@1,COG0497@2 NA|NA|NA L May be involved in recombinational repair of damaged DNA MAG.T12.14_01683 471852.Tcur_2836 1.1e-260 905.6 Streptosporangiales pyrG GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1276,iECO103_1326.ECO103_3323,iHN637.CLJU_RS01075,iNJ661.Rv1699,iPC815.YPO3377 Bacteria 2GJ13@201174,4EFKB@85012,COG0504@1,COG0504@2 NA|NA|NA F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates MAG.T12.14_01684 1177594.MIC448_2500030 5.3e-40 171.0 Microbacteriaceae nudF 3.6.1.13 ko:K01515 ko00230,map00230 R01054 RC00002 ko00000,ko00001,ko01000 Bacteria 2GNW6@201174,4FNIB@85023,COG0494@1,COG0494@2 NA|NA|NA L NUDIX domain MAG.T12.14_01685 219305.MCAG_04961 5.5e-158 563.9 Micromonosporales ald 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 R00396 RC00008 ko00000,ko00001,ko01000 Bacteria 2GJ6G@201174,4DA3S@85008,COG0686@1,COG0686@2 NA|NA|NA C Belongs to the AlaDH PNT family MAG.T12.14_01686 1120950.KB892767_gene5149 3.8e-104 384.8 Propionibacteriales xerD GO:0008150,GO:0040007 ko:K03733,ko:K04763 ko00000,ko03036 Bacteria 2GNDP@201174,4DNSC@85009,COG4974@1,COG4974@2 NA|NA|NA L tyrosine recombinase MAG.T12.14_01687 351607.Acel_1240 1.7e-104 386.0 Frankiales soj GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009295,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044464,GO:0071944 ko:K03496 ko00000,ko03036,ko04812 Bacteria 2GJX3@201174,4ERYA@85013,COG1192@1,COG1192@2 NA|NA|NA D PFAM Cobyrinic acid a,c-diamide synthase MAG.T12.14_01688 1283287.KB822585_gene2646 7.8e-80 303.9 Propionibacteriales scpA ko:K05896 ko00000,ko03036 Bacteria 2GN1U@201174,4DMYR@85009,COG1354@1,COG1354@2 NA|NA|NA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves MAG.T12.14_01689 1122611.KB904029_gene5405 5.3e-54 217.6 Streptosporangiales scpB ko:K06024 ko00000,ko03036 Bacteria 2GISY@201174,4EG7D@85012,COG1386@1,COG1386@2 NA|NA|NA K Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves MAG.T12.14_01690 1184607.AUCHE_05_03990 2.2e-83 315.5 Dermatophilaceae rluB GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.19,5.4.99.22 ko:K06178,ko:K06183 ko00000,ko01000,ko03009 Bacteria 2GJ4N@201174,4F65G@85018,COG1187@1,COG1187@2 NA|NA|NA J RNA pseudouridylate synthase MAG.T12.14_01691 1463881.KL591011_gene2890 7.2e-35 153.3 Actinobacteria aroH GO:0003674,GO:0003824,GO:0004106,GO:0006082,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016866,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044281,GO:0046417,GO:0071704 2.7.4.25,5.4.99.5 ko:K00945,ko:K06208 ko00240,ko00400,ko01100,ko01110,ko01130,ko01230,map00240,map00400,map01100,map01110,map01130,map01230 M00024,M00025,M00052 R00158,R00512,R01665,R01715 RC00002,RC03116 ko00000,ko00001,ko00002,ko01000 Bacteria 2IHWT@201174,COG4401@1,COG4401@2 NA|NA|NA E Chorismate mutase MAG.T12.14_01692 1210046.B277_08400 4.7e-82 311.6 Intrasporangiaceae tyrA 1.3.1.12,1.3.1.43 ko:K00210,ko:K00220,ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025,M00040 R00732,R01728 RC00125 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKB4@201174,4FF8J@85021,COG0287@1,COG0287@2 NA|NA|NA E Prephenate dehydrogenase MAG.T12.14_01693 1229203.KI301992_gene1081 1e-56 226.9 unclassified Actinobacteria (class) cmk GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 ko:K00945,ko:K03977 ko00240,ko01100,map00240,map01100 M00052 R00158,R00512,R01665 RC00002 ko00000,ko00001,ko00002,ko01000,ko03009 Bacteria 2H3SI@201174,3UWT7@52018,COG0283@1,COG0283@2 NA|NA|NA F Cytidylate kinase MAG.T12.14_01694 1463856.JOHY01000043_gene7260 7.9e-184 650.2 Actinobacteria der GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 1.1.1.399,1.1.1.95 ko:K00058,ko:K03977 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko03009,ko04147 Bacteria 2GJ8J@201174,COG1160@1,COG1160@2 NA|NA|NA F GTPase that plays an essential role in the late steps of ribosome biogenesis MAG.T12.14_01695 1043493.BBLU01000021_gene657 3.1e-54 218.0 Actinobacteria ko:K06929 ko00000 Bacteria 2IJYY@201174,COG1832@1,COG1832@2 NA|NA|NA S PFAM CoA-binding domain protein MAG.T12.14_01697 1121385.AQXW01000004_gene3278 9.4e-15 86.3 Dermacoccaceae phhB 3.5.4.33,4.2.1.96 ko:K01724,ko:K11991 ko00790,map00790 R04734,R10223 RC00477,RC01208 ko00000,ko00001,ko01000,ko03016,ko04147 Bacteria 1ZW7J@145357,2IHZE@201174,COG2154@1,COG2154@2 NA|NA|NA H Pterin 4 alpha carbinolamine dehydratase MAG.T12.14_01698 1150399.AQYK01000002_gene2654 4.6e-205 721.5 Microbacteriaceae tagX 2.7.8.12 ko:K09809 ko00000,ko01000 Bacteria 2GM0T@201174,4FK9M@85023,COG0438@1,COG0438@2,COG1887@1,COG1887@2 NA|NA|NA M CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase MAG.T12.14_01699 33876.JNXY01000002_gene363 5e-51 209.5 Actinobacteria Bacteria 2IR52@201174,COG1525@1,COG1525@2 NA|NA|NA L Lamin Tail Domain MAG.T12.14_01702 477641.MODMU_4618 3.3e-47 194.9 Frankiales bar 2.3.1.183 ko:K03823 ko00440,ko01130,map00440,map01130 R08871,R08938 RC00004,RC00064 ko00000,ko00001,ko01000 Bacteria 2IHSY@201174,4EVJN@85013,COG1247@1,COG1247@2 NA|NA|NA M Acetyltransferase (GNAT) domain MAG.T12.14_01703 471852.Tcur_0810 9.6e-252 875.9 Streptosporangiales ercc3 3.6.4.12 ko:K10843 ko03022,ko03420,map03022,map03420 M00290 ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 Bacteria 2GIR9@201174,4EHX6@85012,COG1061@1,COG1061@2 NA|NA|NA L ERCC3/RAD25/XPB C-terminal helicase MAG.T12.14_01704 1003195.SCAT_2429 5.2e-107 395.6 Actinobacteria M1-1077 Bacteria 2GURQ@201174,COG2378@1,COG2378@2 NA|NA|NA K Helicase conserved C-terminal domain MAG.T12.14_01706 743718.Isova_2592 7.1e-41 173.3 Promicromonosporaceae cspB ko:K03704 ko00000,ko03000 Bacteria 2IKXN@201174,4F4QM@85017,COG1278@1,COG1278@2 NA|NA|NA K Cold shock protein domain MAG.T12.14_01707 1206101.AZXC01000007_gene2428 6.7e-09 67.4 Actinobacteria Bacteria 2F261@1,2IFIE@201174,33V4D@2 NA|NA|NA MAG.T12.14_01708 1048339.KB913029_gene2148 2.2e-62 245.7 Frankiales Bacteria 28NWB@1,2GJ74@201174,2ZBU7@2,4ESJV@85013 NA|NA|NA S Protein of unknown function (DUF3027) MAG.T12.14_01709 656024.FsymDg_0268 4.8e-07 60.5 Frankiales Bacteria 2ETMT@1,2HU3T@201174,33M5J@2,4EWV2@85013 NA|NA|NA S Protein of unknown function (DUF2530) MAG.T12.14_01710 1123320.KB889723_gene7524 2.9e-46 192.6 Actinobacteria Bacteria 2GNAZ@201174,COG3386@1,COG3386@2 NA|NA|NA G PFAM SMP-30 Gluconolaconase MAG.T12.14_01711 1150864.MILUP08_42574 8.6e-43 179.9 Micromonosporales Bacteria 2HR7I@201174,4DFE0@85008,COG2315@1,COG2315@2 NA|NA|NA S YjbR MAG.T12.14_01712 644283.Micau_0514 8.6e-151 540.0 Micromonosporales serC GO:0001505,GO:0003674,GO:0003824,GO:0004760,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005886,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006807,GO:0008150,GO:0008152,GO:0008453,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019265,GO:0019752,GO:0040007,GO:0042133,GO:0042136,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0065007,GO:0065008,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 2GKYK@201174,4D8WE@85008,COG1932@1,COG1932@2 NA|NA|NA EH Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine MAG.T12.14_01713 285535.JOEY01000002_gene4814 4.7e-173 614.0 Actinobacteria citA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GKST@201174,COG0372@1,COG0372@2 NA|NA|NA C Belongs to the citrate synthase family MAG.T12.14_01714 1449347.JQLN01000005_gene4049 3.1e-55 221.9 Kitasatospora pdxH 1.4.3.5 ko:K00275 ko00750,ko01100,ko01120,map00750,map01100,map01120 M00124 R00277,R00278,R01710,R01711 RC00048,RC00116 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJCR@201174,2M25F@2063,COG0259@1,COG0259@2 NA|NA|NA H Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) MAG.T12.14_01715 765420.OSCT_1250 1.3e-21 110.2 Chloroflexia ko:K08981 ko00000 Bacteria 2G70V@200795,375QN@32061,COG3428@1,COG3428@2 NA|NA|NA S PFAM membrane-flanked domain MAG.T12.14_01716 469383.Cwoe_0732 5.3e-74 284.6 Actinobacteria ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2I2DK@201174,COG4152@1,COG4152@2 NA|NA|NA S ABC transporter MAG.T12.14_01717 543632.JOJL01000027_gene2595 1.1e-39 171.0 Micromonosporales ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2I9MY@201174,4DCFI@85008,COG1668@1,COG1668@2 NA|NA|NA CP ABC-2 family transporter protein MAG.T12.14_01718 287986.DV20_43550 2.9e-147 528.1 Pseudonocardiales Bacteria 2H0AR@201174,4E90A@85010,COG0627@1,COG0627@2 NA|NA|NA S Putative esterase MAG.T12.14_01721 1068980.ARVW01000001_gene8375 1.6e-52 213.0 Pseudonocardiales parA ko:K03496 ko00000,ko03036,ko04812 Bacteria 2H4UC@201174,4DZB6@85010,COG1192@1,COG1192@2 NA|NA|NA D involved in chromosome partitioning MAG.T12.14_01722 1123320.KB889746_gene8006 2.4e-136 492.3 Actinobacteria phrB GO:0000003,GO:0000166,GO:0000719,GO:0001101,GO:0002252,GO:0002376,GO:0003006,GO:0003674,GO:0003824,GO:0003904,GO:0003913,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005773,GO:0006139,GO:0006259,GO:0006281,GO:0006290,GO:0006325,GO:0006338,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006873,GO:0006874,GO:0006875,GO:0006950,GO:0006952,GO:0006974,GO:0006996,GO:0007154,GO:0007165,GO:0007275,GO:0007623,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009314,GO:0009414,GO:0009415,GO:0009416,GO:0009605,GO:0009606,GO:0009607,GO:0009615,GO:0009628,GO:0009637,GO:0009638,GO:0009642,GO:0009645,GO:0009646,GO:0009648,GO:0009719,GO:0009725,GO:0009785,GO:0009791,GO:0009881,GO:0009882,GO:0009888,GO:0009893,GO:0009909,GO:0009911,GO:0009987,GO:0010033,GO:0010035,GO:0010073,GO:0010075,GO:0010118,GO:0010228,GO:0010244,GO:0010617,GO:0014070,GO:0016043,GO:0016604,GO:0016829,GO:0016830,GO:0017076,GO:0018298,GO:0019222,GO:0019538,GO:0019637,GO:0019725,GO:0022414,GO:0022603,GO:0023052,GO:0030003,GO:0030522,GO:0030554,GO:0031323,GO:0031325,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0033993,GO:0034641,GO:0035639,GO:0036094,GO:0036211,GO:0038023,GO:0040008,GO:0042221,GO:0042592,GO:0042726,GO:0042752,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0048037,GO:0048507,GO:0048509,GO:0048511,GO:0048518,GO:0048522,GO:0048571,GO:0048573,GO:0048574,GO:0048580,GO:0048582,GO:0048583,GO:0048608,GO:0048638,GO:0048731,GO:0048831,GO:0048856,GO:0048878,GO:0050660,GO:0050662,GO:0050789,GO:0050793,GO:0050794,GO:0050801,GO:0050896,GO:0051094,GO:0051186,GO:0051239,GO:0051240,GO:0051276,GO:0051480,GO:0051607,GO:0051704,GO:0051707,GO:0051716,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0055086,GO:0060089,GO:0061458,GO:0065007,GO:0065008,GO:0070013,GO:0071214,GO:0071478,GO:0071482,GO:0071483,GO:0071704,GO:0071840,GO:0071949,GO:0072387,GO:0072503,GO:0072507,GO:0090304,GO:0097159,GO:0097367,GO:0098542,GO:0098771,GO:0104004,GO:0140097,GO:1900618,GO:1901265,GO:1901360,GO:1901363,GO:1901371,GO:1901564,GO:1901700,GO:1902347,GO:1905421,GO:2000024,GO:2000026,GO:2000028,GO:2000241,GO:2000243,GO:2000377,GO:2000379 4.1.99.3 ko:K01669 ko00000,ko01000,ko03400 Bacteria 2GJXU@201174,COG0415@1,COG0415@2 NA|NA|NA L Belongs to the DNA photolyase family MAG.T12.14_01723 1206101.AZXC01000007_gene2475 3.7e-64 251.5 Actinobacteria ideR ko:K03709 ko00000,ko03000 Bacteria 2GKMC@201174,COG1321@1,COG1321@2 NA|NA|NA K iron dependent repressor MAG.T12.14_01724 1463820.JOGW01000004_gene4608 3.4e-21 107.5 Actinobacteria ko:K21600 ko00000,ko03000 Bacteria 2IQ7U@201174,COG1937@1,COG1937@2 NA|NA|NA S protein conserved in bacteria MAG.T12.14_01725 479435.Kfla_0631 2.2e-30 139.0 Propionibacteriales lytE ko:K21471 ko00000,ko01000,ko01002,ko01011 Bacteria 2IFNI@201174,4DS9B@85009,COG0791@1,COG0791@2,COG3409@1,COG3409@2 NA|NA|NA M NlpC/P60 family MAG.T12.14_01726 1240349.ANGC01000010_gene2821 1.8e-92 346.7 Nocardiaceae 2.3.1.20 ko:K00635 ko00561,ko01100,map00561,map01100 M00089 R02251 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 Bacteria 2IGNH@201174,4G6IZ@85025,COG1020@1,COG1020@2 NA|NA|NA I Protein of unknown function (DUF1298) MAG.T12.14_01727 477641.MODMU_4177 8.4e-106 390.2 Frankiales 1.13.11.8 ko:K04100,ko:K15777 ko00362,ko00624,ko00627,ko00965,ko01120,map00362,map00624,map00627,map00965,map01120 R01632,R03550,R04280,R08836,R09565 RC00233,RC00387,RC00535,RC02567,RC02694 br01602,ko00000,ko00001,ko01000 Bacteria 2GKTV@201174,4ESG8@85013,COG3384@1,COG3384@2 NA|NA|NA S Extradiol ring-cleavage dioxygenase class III protein subunit B MAG.T12.14_01728 1120954.ATXE01000001_gene2216 3.3e-20 104.8 Propionibacteriales Bacteria 2IT3M@201174,4DVDP@85009,COG3877@1,COG3877@2 NA|NA|NA S Protein of unknown function (DUF2089) MAG.T12.14_01729 479435.Kfla_5620 1.3e-12 80.5 Propionibacteriales Bacteria 2B5R0@1,2IPMA@201174,31YKI@2,4DR93@85009 NA|NA|NA MAG.T12.14_01730 679197.HMPREF9336_04200 1.4e-57 230.7 Actinobacteria Bacteria 2GN56@201174,COG1835@1,COG1835@2 NA|NA|NA I Acyltransferase MAG.T12.14_01731 1144275.COCOR_03122 6.6e-25 120.2 Proteobacteria Bacteria 1NKMZ@1224,COG3832@1,COG3832@2,COG5646@1,COG5646@2 NA|NA|NA S Domain of unknown function (DU1801) MAG.T12.14_01732 1304865.JAGF01000001_gene3097 1.5e-29 135.6 Actinobacteria perX Bacteria 2IFXH@201174,COG2210@1,COG2210@2 NA|NA|NA S DsrE/DsrF/DrsH-like family MAG.T12.14_01733 1283299.AUKG01000005_gene135 1.3e-12 81.6 Rubrobacteria Bacteria 2I4C3@201174,4CQSU@84995,COG0823@1,COG0823@2 NA|NA|NA U Involved in the tonB-independent uptake of proteins MAG.T12.14_01734 1380370.JIBA01000012_gene3687 4.8e-30 136.7 Actinobacteria Bacteria 2EAYY@1,2I2ZT@201174,334ZV@2 NA|NA|NA S Protein of unknown function (DUF4242) MAG.T12.14_01735 1123023.JIAI01000001_gene6982 2.3e-08 65.5 Pseudonocardiales ko:K06893 ko00000 Bacteria 2HPCK@201174,4E7Y5@85010,COG5485@1,COG5485@2 NA|NA|NA S SnoaL-like polyketide cyclase MAG.T12.14_01736 1136417.AZWE01000022_gene2611 1.1e-31 143.3 Micromonosporales Bacteria 2ENA9@1,2IS82@201174,33FXZ@2,4DF28@85008 NA|NA|NA MAG.T12.14_01738 266940.Krad_3445 3.4e-96 358.2 Actinobacteria aroE GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 Bacteria 2GPXV@201174,COG0169@1,COG0169@2 NA|NA|NA E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) MAG.T12.14_01739 1463881.KL591002_gene4566 6.4e-28 131.0 Bacteria yahN GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015318,GO:0015711,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1903825,GO:1905039 ko:K03329,ko:K16327 ko00000,ko02000 2.A.76.1.3,2.A.76.1.6 Bacteria COG1280@1,COG1280@2 NA|NA|NA E homoserine transmembrane transporter activity MAG.T12.14_01740 743718.Isova_0180 2.2e-70 272.3 Promicromonosporaceae tipA ko:K21744 ko00000,ko03000 Bacteria 2H5GI@201174,4F45E@85017,COG0789@1,COG0789@2 NA|NA|NA K TipAS antibiotic-recognition domain MAG.T12.14_01741 767434.Fraau_3109 2.3e-49 201.8 Xanthomonadales trmL GO:0001510,GO:0002128,GO:0002130,GO:0002131,GO:0002132,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.207 ko:K03216 ko00000,ko01000,ko03016 Bacteria 1RCY4@1224,1S3PI@1236,1X643@135614,COG0219@1,COG0219@2 NA|NA|NA J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide MAG.T12.14_01742 742722.HMPREF9463_00308 3e-113 416.0 Coriobacteriia ko:K06147,ko:K12531 ko02020,map02020 M00326 ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 2I6AF@201174,4CUQX@84998,COG5265@1,COG5265@2 NA|NA|NA O ABC transporter MAG.T12.14_01743 266940.Krad_3698 4e-50 206.1 Actinobacteria 2.7.13.3,3.1.3.3 ko:K07315,ko:K07654,ko:K07675 ko02020,map02020 M00461,M00473 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko03021 Bacteria 2IHH3@201174,COG2208@1,COG2208@2,COG3850@1,COG3850@2 NA|NA|NA KT stage II sporulation MAG.T12.14_01744 367299.JOEE01000002_gene2547 1.3e-67 263.5 Intrasporangiaceae 1.1.1.65 ko:K05275 ko00750,ko01100,ko01120,map00750,map01100,map01120 R01708 RC00116 ko00000,ko00001,ko01000 Bacteria 2GJ6R@201174,4FG84@85021,COG0667@1,COG0667@2 NA|NA|NA C Aldo/keto reductase family MAG.T12.14_01745 469371.Tbis_2750 3.9e-169 601.3 Pseudonocardiales cydA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0016682,GO:0019646,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0070069,GO:0071944,GO:0097159,GO:1901363 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 iPC815.YPO1117,iSBO_1134.SBO_2253,iSFxv_1172.SFxv_0621,iS_1188.S0577,iSbBS512_1146.SbBS512_E2337 Bacteria 2GJE4@201174,4DZRD@85010,COG1271@1,COG1271@2 NA|NA|NA C Cytochrome bd-type quinol oxidase, subunit 1 MAG.T12.14_01746 35754.JNYJ01000014_gene4724 7.2e-120 437.2 Micromonosporales cydB GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0016682,GO:0019646,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0070069,GO:0071944,GO:0097159,GO:1901363 1.10.3.14 ko:K00426 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 iECABU_c1320.ECABU_c10120,iLF82_1304.LF82_0101,iNRG857_1313.NRG857_04455,iPC815.YPO1118,ic_1306.c1120 Bacteria 2GMFV@201174,4DATV@85008,COG1294@1,COG1294@2 NA|NA|NA C cytochrome d ubiquinol oxidase, subunit MAG.T12.14_01747 1123320.KB889730_gene6071 1.2e-121 443.7 Actinobacteria Bacteria 2GIWI@201174,COG3850@1,COG3850@2 NA|NA|NA T Histidine kinase MAG.T12.14_01748 1134445.AJJM01000001_gene2720 1.6e-127 463.4 Actinobacteria cydC ko:K06148,ko:K16012,ko:K16013,ko:K16014 ko02010,map02010 ko00000,ko00001,ko02000 3.A.1,3.A.1.129 Bacteria 2I2DP@201174,COG4987@1,COG4987@2,COG4988@1,COG4988@2 NA|NA|NA V ABC transporter CydDC cysteine exporter (CydDC-E) family permease ATP-binding protein CydD MAG.T12.14_01749 591159.ACEZ01000134_gene2353 7.9e-145 520.8 Actinobacteria cydC ko:K06148,ko:K16012,ko:K16013,ko:K16014 ko02010,map02010 ko00000,ko00001,ko02000 3.A.1,3.A.1.129 Bacteria 2I2DP@201174,COG4987@1,COG4987@2,COG4988@1,COG4988@2 NA|NA|NA V ABC transporter CydDC cysteine exporter (CydDC-E) family permease ATP-binding protein CydD MAG.T12.14_01750 67257.JODR01000002_gene1060 3.6e-95 354.8 Actinobacteria 3.6.3.17 ko:K02056 M00221 ko00000,ko00002,ko01000,ko02000 3.A.1.2 Bacteria 2GJDV@201174,COG1129@1,COG1129@2 NA|NA|NA G ABC transporter MAG.T12.14_01751 1122939.ATUD01000006_gene1730 6e-90 337.8 Rubrobacteria iolTB ko:K02057,ko:K03466 M00221 ko00000,ko00002,ko02000,ko03036 3.A.1.2,3.A.12 Bacteria 2GM9E@201174,4CPYC@84995,COG1172@1,COG1172@2 NA|NA|NA G Branched-chain amino acid transport system / permease component MAG.T12.14_01752 1380390.JIAT01000017_gene5376 2.5e-64 252.7 Rubrobacteria iolTA ko:K02058,ko:K10439 ko02010,ko02030,map02010,map02030 M00212,M00221 ko00000,ko00001,ko00002,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 Bacteria 2GKIJ@201174,4CQ39@84995,COG1879@1,COG1879@2 NA|NA|NA G Periplasmic binding protein domain MAG.T12.14_01753 1894.JOER01000011_gene2071 4.1e-81 307.8 Actinobacteria Bacteria 2GK4B@201174,COG2197@1,COG2197@2 NA|NA|NA T response regulator MAG.T12.14_01754 1211815.CBYP010000047_gene1633 1.1e-96 360.5 Frankiales hemA GO:0005575,GO:0005623,GO:0008150,GO:0009288,GO:0040007,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040 1.2.1.70 ko:K02407,ko:K02492 ko00860,ko01100,ko01110,ko01120,ko02040,map00860,map01100,map01110,map01120,map02040 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000,ko02035 iSB619.SA_RS08420 Bacteria 2GJRA@201174,4ERHS@85013,COG0373@1,COG0373@2 NA|NA|NA H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) MAG.T12.14_01755 996637.SGM_1352 1.4e-74 286.6 Actinobacteria hemC GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 Bacteria 2GMWI@201174,COG0181@1,COG0181@2 NA|NA|NA H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps MAG.T12.14_01756 471852.Tcur_4438 8.1e-163 580.5 Streptosporangiales hemD GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 ko:K02302,ko:K02303,ko:K13542 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03165,R03194,R03947 RC00003,RC00871,RC01012,RC01034,RC01861 ko00000,ko00001,ko00002,ko01000 Bacteria 2GMJZ@201174,4EFW8@85012,COG0007@1,COG0007@2,COG1587@1,COG1587@2 NA|NA|NA H Uroporphyrinogen-III synthase HemD MAG.T12.14_01757 1033730.CAHG01000016_gene574 3.1e-163 581.6 Propionibacteriales hisS 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 2GIYJ@201174,4DP1N@85009,COG0124@1,COG0124@2 NA|NA|NA J Histidine--tRNA ligase MAG.T12.14_01758 935866.JAER01000015_gene1674 2.1e-75 288.9 Propionibacteriales ycbL 3.1.2.6 ko:K01069 ko00620,map00620 R01736 RC00004,RC00137 ko00000,ko00001,ko01000 Bacteria 2GJU0@201174,4DNMS@85009,COG0491@1,COG0491@2 NA|NA|NA S Metallo-beta-lactamase superfamily MAG.T12.14_01759 1504319.GM45_5185 3.1e-54 218.8 unclassified Actinobacteria (class) 5.2.1.8 ko:K01802,ko:K03768 ko00000,ko01000,ko03110 Bacteria 2GN8G@201174,3UWKX@52018,COG0652@1,COG0652@2 NA|NA|NA O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides MAG.T12.14_01760 1894.JOER01000023_gene7347 6.6e-88 331.3 Actinobacteria Bacteria 2GJBD@201174,COG1196@1,COG1196@2 NA|NA|NA D Domain of Unknown Function (DUF349) MAG.T12.14_01761 351607.Acel_1338 1.7e-299 1035.0 Frankiales relA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009259,GO:0009260,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0015969,GO:0015970,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034035,GO:0034036,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042578,GO:0042594,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044419,GO:0044464,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051704,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 Bacteria 2GJYQ@201174,4EREV@85013,COG0317@1,COG0317@2 NA|NA|NA KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance MAG.T12.14_01762 1123322.KB904647_gene1647 3.9e-93 348.6 Actinobacteria secF GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 ko:K03072,ko:K03074,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 Bacteria 2GJRS@201174,COG0341@1,COG0341@2 NA|NA|NA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA MAG.T12.14_01763 1504319.GM45_5165 3e-115 422.5 unclassified Actinobacteria (class) secD GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 Bacteria 2GJTT@201174,3UWKE@52018,COG0342@1,COG0342@2 NA|NA|NA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA MAG.T12.14_01764 570268.ANBB01000054_gene4590 1.1e-139 503.1 Streptosporangiales ruvB GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 3.6.4.12 ko:K03551 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 2GJZF@201174,4EH70@85012,COG2255@1,COG2255@2 NA|NA|NA L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing MAG.T12.14_01765 1120950.KB892708_gene4274 1.4e-51 209.5 Propionibacteriales ruvA GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 ko:K03550 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 2GN17@201174,4DQ7Y@85009,COG0632@1,COG0632@2 NA|NA|NA L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB MAG.T12.14_01766 471852.Tcur_2109 1.8e-51 209.1 Streptosporangiales ruvC GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 ko:K01159 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 2GJI5@201174,4EIKP@85012,COG0817@1,COG0817@2 NA|NA|NA L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group MAG.T12.14_01767 557599.MKAN_09615 1.8e-93 350.1 Mycobacteriaceae Bacteria 235TY@1762,2GKU0@201174,COG1020@1,COG1020@2 NA|NA|NA Q Diacylglycerol O-acyltransferase MAG.T12.14_01768 269800.Tfu_2096 3.7e-110 404.4 Streptosporangiales yebC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 Bacteria 2GJ4G@201174,4EGE0@85012,COG0217@1,COG0217@2 NA|NA|NA K Transcriptional regulator MAG.T12.14_01769 1463887.KL589984_gene3407 5.7e-69 267.3 Actinobacteria pdxT GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0071496,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600 4.3.3.6 ko:K08681 ko00750,map00750 R07456 RC00010,RC01783,RC03043 ko00000,ko00001,ko01000 iHN637.CLJU_RS19495 Bacteria 2GNYG@201174,COG0311@1,COG0311@2 NA|NA|NA H Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS MAG.T12.14_01770 644283.Micau_2259 1.8e-143 515.4 Micromonosporales pdxS GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0040007,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 4.3.3.6 ko:K06215 ko00750,map00750 R07456 RC00010,RC01783,RC03043 ko00000,ko00001,ko01000 Bacteria 2GK1T@201174,4DAJ6@85008,COG0214@1,COG0214@2 NA|NA|NA H Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively MAG.T12.14_01771 1120936.KB907223_gene2469 3.4e-58 232.3 Streptosporangiales yerB Bacteria 2GP8D@201174,4EGFU@85012,COG1470@1,COG1470@2 NA|NA|NA S Protein of unknown function (DUF3048) C-terminal domain MAG.T12.14_01772 1157637.KB892156_gene4020 3.6e-38 164.9 Actinobacteria ko:K03744 ko00000 Bacteria 2GK54@201174,COG1704@1,COG1704@2 NA|NA|NA L nUDIX hydrolase MAG.T12.14_01773 1169161.KB897725_gene1738 1.7e-117 429.5 Actinobacteria pimA GO:0000026,GO:0000030,GO:0000287,GO:0003674,GO:0003824,GO:0004376,GO:0004377,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006644,GO:0006650,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0043167,GO:0043169,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046486,GO:0046488,GO:0046872,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.4.1.345 ko:K08256 R11702 ko00000,ko01000,ko01003 GT4 Bacteria 2GKQ8@201174,COG0438@1,COG0438@2 NA|NA|NA M PFAM Glycosyl transferase, group 1 MAG.T12.14_01774 566461.SSFG_05851 5.2e-82 311.2 Actinobacteria htrB GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.3.1.241,2.3.1.265 ko:K02517,ko:K22311 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 Bacteria 2GM7B@201174,COG1560@1,COG1560@2 NA|NA|NA M Lipid A biosynthesis MAG.T12.14_01775 1089455.MOPEL_021_00590 2e-43 182.6 Dermatophilaceae pgsA1 GO:0003674,GO:0003824,GO:0003881,GO:0003882,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.7.8.11,2.7.8.5 ko:K00995,ko:K00999 ko00562,ko00564,ko01100,ko04070,map00562,map00564,map01100,map04070 R01801,R01802 RC00002,RC00017,RC00078,RC02795 ko00000,ko00001,ko01000 Bacteria 2GYKW@201174,4F6UB@85018,COG0558@1,COG0558@2 NA|NA|NA I CDP-alcohol phosphatidyltransferase MAG.T12.14_01776 479433.Caci_2340 2.9e-288 997.7 Actinobacteria fusA2 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0030312,GO:0044237,GO:0044464,GO:0071944 ko:K02355 ko00000,ko03012,ko03029 Bacteria 2GKRU@201174,COG0480@1,COG0480@2 NA|NA|NA J elongation factor G MAG.T12.14_01777 711393.AYRX01000031_gene269 1e-38 166.4 Actinobacteria Bacteria 2IFBJ@201174,COG2050@1,COG2050@2 NA|NA|NA Q Domain of unknown function (DUF4442) MAG.T12.14_01778 44060.JODL01000004_gene2457 3.6e-38 164.9 Actinobacteria Bacteria 2IFC7@201174,COG5083@1,COG5083@2 NA|NA|NA S phosphatidylinositol transporter activity MAG.T12.14_01779 1463857.JOFZ01000004_gene2532 1.8e-147 528.9 Actinobacteria gcvP GO:0003674,GO:0003824,GO:0004375,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016638,GO:0016642,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.4.4.2 ko:K00281,ko:K00282 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 iECIAI39_1322.ECIAI39_3318 Bacteria 2GJ11@201174,COG0403@1,COG0403@2,COG1003@1,COG1003@2 NA|NA|NA E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor MAG.T12.14_01780 1146883.BLASA_2279 1.3e-19 102.4 Frankiales trpB GO:0000162,GO:0003674,GO:0003824,GO:0004834,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 Bacteria 2GM7Z@201174,4ERSM@85013,COG0133@1,COG0133@2 NA|NA|NA E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine MAG.T12.14_01781 1157635.KB892057_gene5130 3.6e-101 374.8 Actinobacteria trpC GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004425,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046391,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.48 ko:K01609 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508 RC00944 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIVV@201174,COG0134@1,COG0134@2 NA|NA|NA E Belongs to the TrpC family MAG.T12.14_01782 1463858.JOHR01000007_gene676 5.7e-15 87.4 Actinobacteria Bacteria 2E37T@1,2GQH5@201174,32Y7G@2 NA|NA|NA S Protein of unknown function (DUF2752) MAG.T12.14_01783 298653.Franean1_1613 8.3e-90 337.8 Frankiales Bacteria 2I53J@201174,4EU80@85013,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor MAG.T12.14_01784 1463825.JNXC01000005_gene2492 3e-82 311.6 Pseudonocardiales Bacteria 2GJE6@201174,4DZNW@85010,COG0745@1,COG0745@2 NA|NA|NA T Transcriptional regulatory protein, C terminal MAG.T12.14_01786 1157637.KB892090_gene6561 1.6e-184 652.5 Actinobacteria trpE 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKJT@201174,COG0147@1,COG0147@2 NA|NA|NA EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia MAG.T12.14_01787 1236902.ANAS01000018_gene3245 7.2e-31 140.2 Streptosporangiales hisI GO:0008150,GO:0040007 3.5.4.19,3.6.1.31 ko:K01496,ko:K11755 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035,R04037 RC00002,RC01055 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1606 Bacteria 2IKKU@201174,4EJM8@85012,COG0139@1,COG0139@2 NA|NA|NA E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP MAG.T12.14_01788 1449347.JQLN01000007_gene1639 8.5e-105 386.7 Kitasatospora hisF GO:0000107,GO:0003674,GO:0003824,GO:0008150,GO:0016740,GO:0016757,GO:0016763,GO:0040007 4.1.3.27 ko:K01657,ko:K02500 ko00340,ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00340,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023,M00026 R00985,R00986,R04558 RC00010,RC01190,RC01943,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIRP@201174,2M09X@2063,COG0107@1,COG0107@2 NA|NA|NA E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit MAG.T12.14_01789 1120948.KB903243_gene2486 3.6e-14 84.3 Pseudonocardiales Bacteria 2E35Q@1,2GS2Q@201174,32Y5M@2,4E724@85010 NA|NA|NA S Short C-terminal domain MAG.T12.14_01790 227882.SAV_1926 7.5e-39 166.8 Actinobacteria Bacteria 2IIN1@201174,COG4803@1,COG4803@2 NA|NA|NA S membrane protein of uknown function UCP014873 MAG.T12.14_01791 1385517.N800_12005 5.4e-64 252.3 Xanthomonadales aarF ko:K03688 ko00000 Bacteria 1MU1Z@1224,1RNQ9@1236,1X410@135614,COG0661@1,COG0661@2 NA|NA|NA S Ubiquinone biosynthesis protein MAG.T12.14_01792 324602.Caur_0429 7.9e-07 61.2 Chloroflexia yvlD ko:K08972 ko00000 Bacteria 2G7E6@200795,375XQ@32061,COG1950@1,COG1950@2 NA|NA|NA S PFAM membrane protein of MAG.T12.14_01793 1380347.JNII01000008_gene4164 5.4e-26 124.0 Frankiales 4.2.99.21 ko:K04782 ko01053,ko01110,ko01130,map01053,map01110,map01130 R06602 RC01549,RC02148 ko00000,ko00001,ko01000 Bacteria 2IIB2@201174,4ETK2@85013,COG0251@1,COG0251@2 NA|NA|NA J Endoribonuclease L-PSP MAG.T12.14_01794 561175.KB894098_gene5366 3.6e-105 387.9 Streptosporangiales hisA GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16,5.3.1.24 ko:K01814,ko:K01817 ko00340,ko00400,ko01100,ko01110,ko01130,ko01230,map00340,map00400,map01100,map01110,map01130,map01230 M00023,M00026 R03509,R04640 RC00945 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ4V@201174,4EGBG@85012,COG0106@1,COG0106@2 NA|NA|NA E Histidine biosynthesis protein MAG.T12.14_01795 1120960.ATXG01000009_gene10 2.1e-82 312.0 Microbacteriaceae hisH GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIYS@201174,4FKZP@85023,COG0118@1,COG0118@2 NA|NA|NA E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR MAG.T12.14_01796 710111.FraQA3DRAFT_6511 1.4e-75 289.3 Frankiales hisB GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0004424,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23,2.6.1.9,3.1.3.15,4.2.1.19 ko:K00013,ko:K00817,ko:K01089,ko:K01693 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R01158,R01163,R03012,R03013,R03243,R03457 RC00006,RC00017,RC00099,RC00242,RC00463,RC00888,RC00932 ko00000,ko00001,ko00002,ko01000,ko01007 iECO111_1330.ECO111_2746,iECS88_1305.ECS88_2121,iJN746.PP_0289,iLJ478.TM1039,iSB619.SA_RS14130,iUMNK88_1353.UMNK88_2570 Bacteria 2GKMD@201174,4ESDH@85013,COG0131@1,COG0131@2 NA|NA|NA E Imidazoleglycerol-phosphate dehydratase MAG.T12.14_01797 408672.NBCG_04907 1.1e-121 443.4 Propionibacteriales hisC GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 2GJ9W@201174,4DPP5@85009,COG0079@1,COG0079@2 NA|NA|NA E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily MAG.T12.14_01798 1996.JOFO01000003_gene6293 2.3e-163 582.0 Streptosporangiales hisD GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23,1.1.1.308 ko:K00013,ko:K15509 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKKA@201174,4EHY2@85012,COG0141@1,COG0141@2 NA|NA|NA E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine MAG.T12.14_01799 1048339.KB913029_gene4558 9e-39 167.2 Frankiales lonD 3.4.21.53 ko:K01338,ko:K07157 ko04112,map04112 ko00000,ko00001,ko01000,ko01002 Bacteria 2GNWA@201174,4ET5K@85013,COG2802@1,COG2802@2 NA|NA|NA S Peptidase S16, lon domain protein MAG.T12.14_01800 1123320.KB889675_gene3833 2.1e-48 198.7 Actinobacteria ybaK GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0043906,GO:0043907,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 ko:K03976 ko00000,ko01000,ko03016 Bacteria 2IHS8@201174,COG2606@1,COG2606@2 NA|NA|NA S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily MAG.T12.14_01801 351607.Acel_1054 0.0 1630.2 Frankiales dnaE 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 2GJ1P@201174,4ERD2@85013,COG0587@1,COG0587@2 NA|NA|NA L DNA polymerase III alpha subunit MAG.T12.14_01802 483219.LILAB_07875 3.5e-177 628.2 Myxococcales fhs GO:0000096,GO:0000097,GO:0000105,GO:0003674,GO:0003824,GO:0004329,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006144,GO:0006520,GO:0006547,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009108,GO:0009110,GO:0009112,GO:0009113,GO:0009256,GO:0009257,GO:0009396,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0016874,GO:0016879,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0052803,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.5.1.5,3.5.4.9,6.3.4.3 ko:K00288,ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00141,M00377 R00943,R01220,R01655 RC00026,RC00111,RC00202,RC00578 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1MUR8@1224,2WJF1@28221,2YZGJ@29,42MKE@68525,COG2759@1,COG2759@2 NA|NA|NA F Belongs to the formate--tetrahydrofolate ligase family MAG.T12.14_01803 471852.Tcur_0033 4e-103 381.3 Streptosporangiales ydbC 1.1.1.65 ko:K05275 ko00750,ko01100,ko01120,map00750,map01100,map01120 R01708 RC00116 ko00000,ko00001,ko01000 Bacteria 2GJ6R@201174,4EICB@85012,COG0667@1,COG0667@2 NA|NA|NA C Aldo/keto reductase family MAG.T12.14_01804 1121017.AUFG01000014_gene2014 1.4e-114 419.5 Intrasporangiaceae rluD GO:0000027,GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022607,GO:0022613,GO:0022618,GO:0031118,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 5.4.99.23,5.4.99.28,5.4.99.29 ko:K06177,ko:K06180 ko00000,ko01000,ko03009,ko03016 iE2348C_1286.E2348C_2868,iECED1_1282.ECED1_3035,iECSF_1327.ECSF_2432 Bacteria 2GIY1@201174,4FFFW@85021,COG0564@1,COG0564@2 NA|NA|NA J Responsible for synthesis of pseudouridine from uracil MAG.T12.14_01805 298654.FraEuI1c_2385 1.5e-36 159.5 Frankiales lspA 3.4.23.36 ko:K03101 ko03060,map03060 ko00000,ko00001,ko01000,ko01002 Bacteria 2GKRX@201174,4ET0T@85013,COG0597@1,COG0597@2 NA|NA|NA MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins MAG.T12.14_01806 1116232.AHBF01000005_gene1545 2.5e-35 155.2 Actinobacteria dksA ko:K06204 ko02026,map02026 ko00000,ko00001,ko03000,ko03009,ko03021 Bacteria 2GJBE@201174,COG1734@1,COG1734@2 NA|NA|NA T Transcriptional regulator, TraR DksA family MAG.T12.14_01807 471857.Svir_27290 1.9e-12 78.6 Pseudonocardiales MA20_25230 ko:K09131 ko00000 Bacteria 2GQSC@201174,4E6KR@85010,COG1872@1,COG1872@2 NA|NA|NA EGP Belongs to the UPF0235 family MAG.T12.14_01809 1122611.KB903943_gene1465 1.5e-06 60.5 Streptosporangiales Bacteria 2E5CN@1,2GM9T@201174,3304R@2,4EJKG@85012 NA|NA|NA MAG.T12.14_01810 1150864.MILUP08_46690 3e-129 468.4 Micromonosporales disA 2.7.7.85 ko:K07067 ko00000,ko01000 Bacteria 2GJ41@201174,4D9EZ@85008,COG1623@1,COG1623@2 NA|NA|NA L Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process MAG.T12.14_01811 570268.ANBB01000033_gene2073 1.6e-141 509.6 Streptosporangiales radA GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 ko:K04485 ko00000,ko03400 Bacteria 2GMQ0@201174,4EG9C@85012,COG1066@1,COG1066@2 NA|NA|NA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function MAG.T12.14_01812 467200.ACFA01000404_gene2616 3.4e-106 391.7 Actinobacteria Bacteria 2GJ6E@201174,COG1082@1,COG1082@2 NA|NA|NA G PFAM Xylose isomerase domain protein TIM barrel MAG.T12.14_01813 931627.MycrhDRAFT_6074 2.9e-66 259.2 Mycobacteriaceae Bacteria 23CKA@1762,2GKPS@201174,COG4850@1,COG4850@2 NA|NA|NA S Uncharacterized conserved protein (DUF2183) MAG.T12.14_01814 1048339.KB913029_gene2309 1.2e-41 177.2 Frankiales ko:K00318 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 R10507 RC00083 ko00000,ko00001,ko01000 Bacteria 2GJTK@201174,4ERCN@85013,COG0506@1,COG0506@2 NA|NA|NA E Proline dehydrogenase MAG.T12.14_01815 1306174.JODP01000006_gene3453 1.4e-70 273.1 Actinobacteria proC GO:0000287,GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0030145,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ7D@201174,COG0345@1,COG0345@2 NA|NA|NA E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline MAG.T12.14_01816 35754.JNYJ01000053_gene6709 5.5e-41 174.5 Micromonosporales trkA ko:K03499 ko00000,ko02000 2.A.38.1,2.A.38.4 Bacteria 2IA09@201174,4DCSC@85008,COG0569@1,COG0569@2 NA|NA|NA P TrkA-C domain MAG.T12.14_01817 1385519.N801_08350 3.7e-102 379.0 Intrasporangiaceae trkH ko:K03498 ko00000,ko02000 2.A.38.1,2.A.38.4 Bacteria 2GKKS@201174,4FG5M@85021,COG0168@1,COG0168@2 NA|NA|NA P Cation transport protein MAG.T12.14_01818 28444.JODQ01000014_gene6728 3.6e-131 474.9 Streptosporangiales acuC ko:K04768 ko00000 iYO844.BSU29710 Bacteria 2GJUH@201174,4EGFY@85012,COG0123@1,COG0123@2 NA|NA|NA BQ Histone deacetylase domain MAG.T12.14_01819 471852.Tcur_4450 4.5e-18 96.7 Streptosporangiales xis Bacteria 2GQGV@201174,4EKJX@85012,COG3311@1,COG3311@2 NA|NA|NA K Helix-turn-helix domain MAG.T12.14_01820 1120950.KB892801_gene1769 1.9e-109 402.5 Propionibacteriales galE2 GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv0501 Bacteria 2GNT1@201174,4DPEE@85009,COG0451@1,COG0451@2 NA|NA|NA GM GDP-mannose 4,6 dehydratase MAG.T12.14_01821 1380393.JHVP01000002_gene1950 1.3e-109 402.9 Frankiales GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 2GJKH@201174,4ESBP@85013,COG0204@1,COG0204@2 NA|NA|NA I PFAM Phospholipid glycerol acyltransferase MAG.T12.14_01822 1122182.KB903837_gene3906 1.9e-95 355.9 Micromonosporales ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GKEH@201174,4D8QU@85008,COG1131@1,COG1131@2 NA|NA|NA V AAA domain, putative AbiEii toxin, Type IV TA system MAG.T12.14_01823 1246995.AFR_08775 1.1e-64 253.4 Micromonosporales ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2ID14@201174,4DCGZ@85008,COG1277@1,COG1277@2 NA|NA|NA S ABC-2 family transporter protein MAG.T12.14_01824 44060.JODL01000048_gene1559 2.3e-72 279.3 Actinobacteria serB1 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K21830 ko00000 Bacteria 2GJW9@201174,COG0560@1,COG0560@2 NA|NA|NA E HAD-superfamily subfamily IB hydrolase, TIGR01490 MAG.T12.14_01825 1122182.KB903813_gene2267 1.5e-118 433.3 Micromonosporales 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 Bacteria 2GIUC@201174,4DBR0@85008,COG0318@1,COG0318@2 NA|NA|NA IQ AMP-binding enzyme C-terminal domain MAG.T12.14_01826 1122609.AUGT01000009_gene3024 1.1e-18 99.0 Propionibacteriales Bacteria 2IR0P@201174,4DS21@85009,COG0695@1,COG0695@2 NA|NA|NA O Glutaredoxin-like domain (DUF836) MAG.T12.14_01827 1172179.AUKV01000016_gene2208 5.1e-189 667.5 Actinobacteria Bacteria 2I7MG@201174,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily MAG.T12.14_01828 1896.JOAU01000002_gene4042 3.1e-75 288.5 Actinobacteria mtnU ko:K11206 ko00000,ko01000 Bacteria 2GMQA@201174,COG0388@1,COG0388@2 NA|NA|NA E Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase MAG.T12.14_01829 1394178.AWOO02000004_gene2330 8.9e-230 803.1 Streptosporangiales acd Bacteria 2GJIB@201174,4EFZX@85012,COG1960@1,COG1960@2 NA|NA|NA I Acyl-CoA dehydrogenase N terminal MAG.T12.14_01830 367299.JOEE01000003_gene2888 1.6e-11 75.9 Intrasporangiaceae Bacteria 2HNF3@201174,4FHWW@85021,COG5652@1,COG5652@2 NA|NA|NA S VanZ like family MAG.T12.14_01831 983917.RGE_30170 1.7e-25 122.9 Bacteria ko:K03830 ko00000,ko01000 Bacteria COG1246@1,COG1246@2 NA|NA|NA E Belongs to the acetyltransferase family. ArgA subfamily MAG.T12.14_01833 1035308.AQYY01000001_gene3431 0.0 1160.2 Peptococcaceae glgP GO:0000272,GO:0003674,GO:0003824,GO:0004645,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0005977,GO:0005980,GO:0006073,GO:0006091,GO:0006112,GO:0008144,GO:0008150,GO:0008152,GO:0008184,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0015980,GO:0016052,GO:0016740,GO:0016757,GO:0016758,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901575 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 R02111 ko00000,ko00001,ko01000 GT35 Bacteria 1TQAJ@1239,248E1@186801,260JM@186807,COG0058@1,COG0058@2 NA|NA|NA G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties MAG.T12.14_01834 443218.AS9A_2736 9.4e-130 469.9 Mycobacteriaceae Bacteria 236RA@1762,2I8ND@201174,COG3832@1,COG3832@2 NA|NA|NA S Activator of Hsp90 ATPase 1 family protein MAG.T12.14_01835 443218.AS9A_2735 2.6e-40 171.4 Mycobacteriaceae Bacteria 239ZN@1762,2IQ55@201174,COG0640@1,COG0640@2 NA|NA|NA K regulatory protein, arsR MAG.T12.14_01836 991905.SL003B_1297 6.1e-145 520.8 unclassified Alphaproteobacteria phlC 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1MUZV@1224,2TRHF@28211,4BSJ0@82117,COG0183@1,COG0183@2 NA|NA|NA I acetyl-coa acetyltransferase MAG.T12.14_01837 991905.SL003B_1298 1.2e-35 156.0 Proteobacteria ko:K07068 ko00000 Bacteria 1RJZS@1224,COG1545@1,COG1545@2 NA|NA|NA S Rubredoxin-like zinc ribbon domain (DUF35_N) MAG.T12.14_01839 471855.Shel_11220 1.5e-66 260.0 Coriobacteriia pta 2.3.1.8 ko:K00625,ko:K13788 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00230,R00921 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ5U@201174,4CVRI@84998,COG0280@1,COG0280@2 NA|NA|NA C PFAM Phosphate acetyl butaryl transferase MAG.T12.14_01840 367299.JOEE01000001_gene1505 3.2e-118 432.2 Intrasporangiaceae enhA_2 Bacteria 2GQ7D@201174,4FIVF@85021,COG1376@1,COG1376@2 NA|NA|NA S Putative peptidoglycan binding domain MAG.T12.14_01841 446470.Snas_0470 1.8e-152 545.8 Glycomycetales bioA 2.6.1.105,2.6.1.62 ko:K00833,ko:K19563 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03231,R10699 RC00006,RC00062,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 iSB619.SA_RS12705 Bacteria 2I2DN@201174,4EY5T@85014,COG0161@1,COG0161@2 NA|NA|NA H Aminotransferase class-III MAG.T12.14_01842 1155718.KB891946_gene4633 1.6e-100 374.0 Actinobacteria Bacteria 2ID4D@201174,COG2124@1,COG2124@2 NA|NA|NA Q Cytochrome P450 MAG.T12.14_01843 479432.Sros_8310 1.8e-63 249.6 Streptosporangiales bioD GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004141,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017076,GO:0017144,GO:0018130,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.47,6.3.3.3 ko:K00652,ko:K01935 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03182,R03210,R10124 RC00004,RC00039,RC00868,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 2GIZ2@201174,4EIRW@85012,COG0132@1,COG0132@2 NA|NA|NA H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring MAG.T12.14_01844 1120936.KB907216_gene3889 4e-144 517.7 Streptosporangiales bioB GO:0003674,GO:0003824,GO:0004076,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0017144,GO:0018130,GO:0019752,GO:0030312,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0070283,GO:0071704,GO:0071944,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1589,iZ_1308.Z0994 Bacteria 2GIUE@201174,4EHMR@85012,COG0502@1,COG0502@2 NA|NA|NA H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism MAG.T12.14_01845 1123024.AUII01000004_gene1673 8e-14 82.8 Pseudonocardiales GO:0002682,GO:0002684,GO:0008150,GO:0009605,GO:0009607,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0075136 Bacteria 2EH0W@1,2GSW1@201174,33ASY@2,4E7W5@85010 NA|NA|NA MAG.T12.14_01846 1150398.JIBJ01000006_gene3690 1.1e-12 79.3 Actinobacteria Bacteria 2DQ6J@1,2GTCR@201174,334Z3@2 NA|NA|NA S Excalibur calcium-binding domain MAG.T12.14_01847 1385518.N798_07485 1.3e-10 75.1 Intrasporangiaceae 3.2.1.4 ko:K01179,ko:K11904,ko:K20276 ko00500,ko01100,ko02024,ko03070,map00500,map01100,map02024,map03070 M00334 R06200,R11307,R11308 ko00000,ko00001,ko00002,ko01000,ko02044 3.A.23.1 GH5,GH9 Bacteria 2I7XV@201174,4FK2V@85021,COG4733@1,COG4733@2,COG4932@1,COG4932@2 NA|NA|NA M Fibronectin type III domain MAG.T12.14_01848 926564.KI911630_gene3158 8.1e-37 161.4 Promicromonosporaceae Bacteria 2DM4W@1,2IK0R@201174,31QNY@2,4F4T1@85017 NA|NA|NA S Winged helix DNA-binding domain MAG.T12.14_01849 1172188.KB911822_gene839 8.8e-56 223.0 Intrasporangiaceae Bacteria 298UU@1,2HY02@201174,2ZVYZ@2,4FIZB@85021 NA|NA|NA S Domain of unknown function (DU1801) MAG.T12.14_01850 1385518.N798_12125 1.6e-51 208.8 Intrasporangiaceae Bacteria 2AKGE@1,2I885@201174,30DHP@2,4FH35@85021 NA|NA|NA MAG.T12.14_01851 1298863.AUEP01000019_gene3531 2e-23 115.2 Actinobacteria Bacteria 2AEBM@1,2HDPF@201174,31462@2 NA|NA|NA MAG.T12.14_01852 1121924.ATWH01000014_gene3488 5.3e-10 70.9 Microbacteriaceae Bacteria 2GYNE@201174,4FSSM@85023,COG2250@1,COG2250@2 NA|NA|NA S HEPN domain MAG.T12.14_01853 710696.Intca_0333 4.4e-27 128.3 Intrasporangiaceae Bacteria 2GUWM@201174,4FJA2@85021,COG1708@1,COG1708@2 NA|NA|NA L Nucleotidyltransferase domain MAG.T12.14_01856 313589.JNB_05894 7.7e-103 380.9 Intrasporangiaceae tig GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944 ko:K03545 ko00000 Bacteria 2GJIG@201174,4FF93@85021,COG0544@1,COG0544@2 NA|NA|NA D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase MAG.T12.14_01857 1048339.KB913029_gene4876 1.7e-84 318.9 Frankiales clpP 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 ko00000,ko00001,ko01000,ko01002 Bacteria 2GK5C@201174,4ES45@85013,COG0740@1,COG0740@2 NA|NA|NA O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins MAG.T12.14_01858 1504319.GM45_5765 1.5e-91 342.4 unclassified Actinobacteria (class) clpP GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 ko00000,ko00001,ko01000,ko01002 Bacteria 2GKNK@201174,3UWGF@52018,COG0740@1,COG0740@2 NA|NA|NA O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins MAG.T12.14_01860 1133850.SHJG_6974 2e-78 299.3 Actinobacteria ceoB ko:K03499 ko00000,ko02000 2.A.38.1,2.A.38.4 Bacteria 2GK4N@201174,COG0569@1,COG0569@2 NA|NA|NA P PFAM TrkA-N domain protein MAG.T12.14_01861 1122611.KB903954_gene5626 4.9e-82 310.8 Streptosporangiales trkA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03499 ko00000,ko02000 2.A.38.1,2.A.38.4 Bacteria 2GKB9@201174,4EGQI@85012,COG0569@1,COG0569@2 NA|NA|NA P TrkA-N domain MAG.T12.14_01862 1120950.KB892748_gene3215 2e-46 192.6 Propionibacteriales Bacteria 2AVV0@1,2GJKP@201174,31MNQ@2,4DQXN@85009 NA|NA|NA S Protein of unknown function (DUF3159) MAG.T12.14_01863 1048339.KB913029_gene3870 5.3e-31 140.6 Frankiales 3.6.4.12 ko:K03655 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 2IHRX@201174,4ETC1@85013,COG1200@1,COG1200@2 NA|NA|NA KL Nucleic acid binding, OB-fold, tRNA MAG.T12.14_01864 593907.Celgi_1460 1.3e-49 203.4 Cellulomonadaceae Bacteria 28J4D@1,2I2E9@201174,30NZ9@2,4F14W@85016 NA|NA|NA S Protein of unknown function (DUF3710) MAG.T12.14_01865 1348663.KCH_54620 4.7e-60 237.3 Kitasatospora dut GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23,4.1.1.36,6.3.2.5 ko:K01520,ko:K13038 ko00240,ko00770,ko00983,ko01100,map00240,map00770,map00983,map01100 M00053,M00120 R02100,R03269,R04231,R11896 RC00002,RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000,ko03400 Bacteria 2IHYY@201174,2M2SY@2063,COG0756@1,COG0756@2 NA|NA|NA F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA MAG.T12.14_01866 68260.JOAY01000013_gene2772 2.3e-51 208.8 Actinobacteria Bacteria 2GKY1@201174,COG2050@1,COG2050@2 NA|NA|NA Q PFAM thioesterase superfamily MAG.T12.14_01867 935839.JAGJ01000003_gene1380 4.7e-18 97.8 Promicromonosporaceae Bacteria 2E4C2@1,2IFS5@201174,32Z7M@2,4F4VX@85017 NA|NA|NA S Protein of unknown function (DUF3093) MAG.T12.14_01869 1184609.KILIM_083_00160 3.4e-38 164.1 Dermatophilaceae Bacteria 2ATJW@1,2IKN0@201174,31J3Z@2,4F70K@85018 NA|NA|NA S Domain of unknown function (DUF4193) MAG.T12.14_01870 298654.FraEuI1c_2264 3.3e-41 174.9 Frankiales Bacteria 2GP22@201174,4EVCG@85013,COG0663@1,COG0663@2 NA|NA|NA S Bacterial transferase hexapeptide (six repeats) MAG.T12.14_01871 1348663.KCH_54540 2.2e-66 259.2 Kitasatospora suhB 3.1.3.25,4.99.1.1,4.99.1.9 ko:K01092,ko:K01772 ko00521,ko00562,ko00860,ko01100,ko01110,ko04070,map00521,map00562,map00860,map01100,map01110,map04070 M00121,M00131 R00310,R01185,R01186,R01187,R11329 RC00078,RC01012 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJQE@201174,2M1IQ@2063,COG0483@1,COG0483@2 NA|NA|NA G Inositol monophosphatase family MAG.T12.14_01872 68223.JNZY01000006_gene4113 5.8e-101 374.4 Actinobacteria hemH GO:0003674,GO:0003824,GO:0004325,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0046148,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051540,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJTQ@201174,COG0276@1,COG0276@2 NA|NA|NA H Catalyzes the ferrous insertion into protoporphyrin IX MAG.T12.14_01873 590998.Celf_2152 3.5e-49 202.6 Cellulomonadaceae GO:0008150,GO:0040007 Bacteria 28PUQ@1,2GNQM@201174,2ZCFK@2,4F1CN@85016 NA|NA|NA S Protein of unknown function (DUF3071) MAG.T12.14_01874 477641.MODMU_3477 1.9e-73 283.1 Frankiales Bacteria 2GISU@201174,4ESFM@85013,COG1524@1,COG1524@2 NA|NA|NA S PFAM type I phosphodiesterase nucleotide pyrophosphatase MAG.T12.14_01875 1120950.KB892748_gene3185 8.5e-54 216.9 Propionibacteriales Bacteria 29850@1,2GKR1@201174,2ZVAX@2,4DQC6@85009 NA|NA|NA MAG.T12.14_01876 1123320.KB889707_gene7976 8e-235 820.5 Actinobacteria iAF987.Gmet_2142 Bacteria 2GKN1@201174,COG0454@1,COG0456@2,COG1042@1,COG1042@2 NA|NA|NA C CoA-binding domain protein MAG.T12.14_01877 446466.Cfla_1693 5.4e-291 1006.9 Cellulomonadaceae gyrA GO:0005575,GO:0005622,GO:0005623,GO:0009330,GO:0032991,GO:0044424,GO:0044464 5.99.1.3 ko:K02469,ko:K02621 ko00000,ko01000,ko02048,ko03032,ko03036,ko03400 Bacteria 2GJ2Q@201174,4F1NX@85016,COG0188@1,COG0188@2 NA|NA|NA L SMART DNA gyrase topoisomerase IV subunit A MAG.T12.14_01878 28042.GU90_11695 1.8e-31 143.3 Pseudonocardiales Bacteria 2GRSQ@201174,4DYIC@85010,COG4759@1,COG4759@2 NA|NA|NA O Sucrase/ferredoxin-like MAG.T12.14_01879 1048339.KB913029_gene4318 9.5e-72 276.9 Frankiales Bacteria 2GMEH@201174,4EUCD@85013,COG1028@1,COG1028@2 NA|NA|NA IQ KR domain MAG.T12.14_01880 1122138.AQUZ01000001_gene1538 3.2e-222 778.1 Propionibacteriales msbA9 ko:K06147 ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 2GITR@201174,4DN7W@85009,COG1132@1,COG1132@2 NA|NA|NA V ABC transporter transmembrane region MAG.T12.14_01881 566461.SSFG_05534 2.9e-65 255.4 Actinobacteria echA Bacteria 2GKC4@201174,COG1024@1,COG1024@2 NA|NA|NA I Belongs to the enoyl-CoA hydratase isomerase family MAG.T12.14_01882 1463845.JOIG01000007_gene549 9e-12 75.9 Actinobacteria Bacteria 2E4I7@1,2IQBB@201174,32ZDA@2 NA|NA|NA S transcriptional regulator MAG.T12.14_01883 479432.Sros_5972 2.8e-208 731.5 Streptosporangiales ybiT Bacteria 2GKQ4@201174,4EG0G@85012,COG0488@1,COG0488@2 NA|NA|NA S ABC transporter MAG.T12.14_01884 1048339.KB913029_gene3748 1e-77 297.0 Frankiales ypfJ GO:0005575,GO:0005576 ko:K07054 ko00000 Bacteria 2H3UT@201174,4ES25@85013,COG2321@1,COG2321@2 NA|NA|NA S Putative neutral zinc metallopeptidase MAG.T12.14_01886 28444.JODQ01000001_gene1881 2.6e-150 538.5 Streptosporangiales chrA ko:K07240 ko00000,ko02000 2.A.51.1 Bacteria 2IB69@201174,4EK6V@85012,COG2059@1,COG2059@2 NA|NA|NA P Chromate transporter MAG.T12.14_01887 1032480.MLP_13020 3.6e-43 181.4 Propionibacteriales Bacteria 2GNA1@201174,4DRXP@85009,COG1695@1,COG1695@2 NA|NA|NA K Transcriptional regulator PadR-like family MAG.T12.14_01888 1125971.ASJB01000080_gene7628 6.2e-65 254.2 Pseudonocardiales lolD ko:K02003 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GM25@201174,4DXIQ@85010,COG1136@1,COG1136@2 NA|NA|NA V ABC-type antimicrobial peptide transport system, ATPase component MAG.T12.14_01889 1033730.CAHG01000016_gene217 4.4e-32 146.0 Propionibacteriales Bacteria 2HZH5@201174,4DSSV@85009,COG0577@1,COG0577@2 NA|NA|NA V efflux transmembrane transporter activity MAG.T12.14_01890 1449069.JMLO01000001_gene1935 9.2e-105 386.3 Nocardiaceae Bacteria 2GMUG@201174,4FZ08@85025,COG2197@1,COG2197@2 NA|NA|NA T cheY-homologous receiver domain MAG.T12.14_01891 1449069.JMLO01000001_gene1936 8e-165 586.6 Nocardiaceae Bacteria 2GS7K@201174,4G082@85025,COG4585@1,COG4585@2 NA|NA|NA T Histidine kinase MAG.T12.14_01892 469383.Cwoe_0678 2.8e-58 231.5 Rubrobacteria Bacteria 2ICAF@201174,313GU@2,4CQYQ@84995,arCOG06733@1 NA|NA|NA MAG.T12.14_01893 1306174.JODP01000001_gene4819 1.2e-19 104.8 Bacteria Bacteria COG5555@1,COG5555@2 NA|NA|NA MAG.T12.14_01894 105420.BBPO01000020_gene5614 5.7e-217 760.4 Streptacidiphilus 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 Bacteria 2IA3D@201174,2NI27@228398,COG3119@1,COG3119@2 NA|NA|NA P Sulfatase MAG.T12.14_01895 1996.JOFO01000054_gene1185 1.4e-55 223.4 Streptosporangiales ko:K07052 ko00000 Bacteria 2GMJ1@201174,4EG7A@85012,COG1266@1,COG1266@2 NA|NA|NA S CAAX protease self-immunity MAG.T12.14_01896 985054.JQEZ01000003_gene1066 2.6e-31 143.7 Alphaproteobacteria 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUMZ@1224,2TUKX@28211,COG0457@1,COG0457@2,COG5616@1,COG5616@2 NA|NA|NA T Adenylate cyclase MAG.T12.14_01897 298655.KI912266_gene5611 2.5e-71 275.8 Frankiales ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GN8P@201174,4EV93@85013,COG1131@1,COG1131@2 NA|NA|NA V ABC transporter MAG.T12.14_01898 471853.Bcav_0362 7.2e-19 101.3 Actinobacteria ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2IRIX@201174,COG1277@1,COG1277@2 NA|NA|NA S ABC-type transport system involved in multi-copper enzyme maturation permease component MAG.T12.14_01899 1133850.SHJG_5771 5.3e-15 88.2 Actinobacteria Bacteria 2GKW3@201174,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family MAG.T12.14_01900 292564.Cyagr_1692 4.9e-135 487.6 Cyanobacteria arsB GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015104,GO:0015105,GO:0015291,GO:0015297,GO:0015318,GO:0015698,GO:0015699,GO:0015700,GO:0016020,GO:0022804,GO:0022857,GO:0034220,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656 1.20.4.1 ko:K03325,ko:K03741 ko00000,ko01000,ko02000 2.A.59 iYO844.BSU25790 Bacteria 1G05E@1117,COG0798@1,COG0798@2 NA|NA|NA P PFAM Sodium Bile acid symporter family MAG.T12.14_01901 1209989.TepiRe1_2456 1.8e-21 108.2 Thermoanaerobacterales Bacteria 1VEYC@1239,24QMF@186801,42H6Q@68295,COG0526@1,COG0526@2 NA|NA|NA CO redox-active disulfide protein 2 MAG.T12.14_01902 479431.Namu_2554 7.9e-20 102.8 Actinobacteria Bacteria 2GUBI@201174,COG0526@1,COG0526@2 NA|NA|NA CO redox-active disulfide protein 2 MAG.T12.14_01903 479431.Namu_2555 1.6e-146 525.8 Bacteria ko:K07089 ko00000 Bacteria COG0701@1,COG0701@2 NA|NA|NA S Predicted permease MAG.T12.14_01904 1304865.JAGF01000001_gene3289 5.2e-20 103.6 Actinobacteria arsR ko:K03892 ko00000,ko03000 Bacteria 2GQU5@201174,COG0640@1,COG0640@2 NA|NA|NA K PFAM regulatory protein, ArsR MAG.T12.14_01905 1035308.AQYY01000002_gene103 2.9e-24 118.6 Peptococcaceae cdr2 Bacteria 1TPWW@1239,2484C@186801,2606T@186807,COG0446@1,COG0446@2 NA|NA|NA P pyridine nucleotide-disulphide oxidoreductase dimerisation MAG.T12.14_01906 591159.ACEZ01000001_gene6027 5.8e-60 237.7 Actinobacteria glpF ko:K02440,ko:K06188 ko00000,ko02000 1.A.8,1.A.8.1,1.A.8.2 Bacteria 2GMG4@201174,COG0580@1,COG0580@2 NA|NA|NA G Belongs to the MIP aquaporin (TC 1.A.8) family MAG.T12.14_01907 1906.SFRA_16750 5.7e-57 226.9 Actinobacteria arsC 1.20.4.1 ko:K03741 ko00000,ko01000 Bacteria 2IHR3@201174,COG0394@1,COG0394@2 NA|NA|NA T Belongs to the low molecular weight phosphotyrosine protein phosphatase family MAG.T12.14_01908 1121019.AUMN01000033_gene2670 3.7e-42 177.6 Actinobacteria Bacteria 2GPFR@201174,COG4374@1,COG4374@2 NA|NA|NA S PIN domain MAG.T12.14_01909 1380386.JIAW01000031_gene3544 1.3e-19 102.1 Actinobacteria Bacteria 2HD6A@201174,COG2002@1,COG2002@2 NA|NA|NA K toxin-antitoxin pair type II binding MAG.T12.14_01910 477641.MODMU_1575 1.2e-18 98.6 Actinobacteria GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007 Bacteria 2FDS3@1,2GUMT@201174,345T0@2 NA|NA|NA S Evidence 4 Homologs of previously reported genes of MAG.T12.14_01911 1146883.BLASA_1416 5.7e-35 153.3 Actinobacteria mazF5 GO:0008150,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0065007 ko:K07171 ko00000,ko01000,ko02048 Bacteria 2IMGQ@201174,COG2337@1,COG2337@2 NA|NA|NA T Evidence 2b Function of strongly homologous gene MAG.T12.14_01915 446471.Xcel_2492 3.3e-81 308.1 Promicromonosporaceae sigH GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141 ko:K03088 ko00000,ko03021 Bacteria 2GJ02@201174,4F3JN@85017,COG1595@1,COG1595@2 NA|NA|NA K Sigma-70, region 4 MAG.T12.14_01916 351607.Acel_0539 6.4e-18 96.7 Frankiales rsrA GO:0000988,GO:0000989,GO:0003674,GO:0005488,GO:0006950,GO:0006979,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009593,GO:0009628,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032502,GO:0042221,GO:0043167,GO:0043169,GO:0043934,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051606,GO:0051775,GO:0051776,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141 Bacteria 2IM2X@201174,4ETFE@85013,COG5662@1,COG5662@2 NA|NA|NA K anti-sigma factor MAG.T12.14_01917 1192034.CAP_5004 4.7e-23 114.4 Myxococcales Bacteria 1NBEP@1224,2E4IQ@1,2WW82@28221,2YVWC@29,32ZDS@2,431T4@68525 NA|NA|NA MAG.T12.14_01918 1385518.N798_03110 2e-23 115.5 Intrasporangiaceae Bacteria 2DRYE@1,2IS24@201174,33DPC@2,4FHPE@85021 NA|NA|NA MAG.T12.14_01919 351607.Acel_0550 1.1e-158 566.2 Frankiales pilT ko:K02669 ko00000,ko02035,ko02044 3.A.15.2 Bacteria 2HPWY@201174,4EUA1@85013,COG2805@1,COG2805@2 NA|NA|NA NU Type II/IV secretion system protein MAG.T12.14_01920 68194.JNXR01000016_gene7360 9.4e-20 103.2 Actinobacteria Bacteria 2IKZP@201174,COG5496@1,COG5496@2 NA|NA|NA S Thioesterase MAG.T12.14_01921 1123320.KB889733_gene6240 1.8e-102 379.4 Actinobacteria 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 Bacteria 2GP4W@201174,COG0449@1,COG0449@2 NA|NA|NA M PFAM Sugar isomerase (SIS) MAG.T12.14_01922 28444.JODQ01000015_gene1617 1.4e-100 373.6 Streptosporangiales pdtaS GO:0000155,GO:0000160,GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005524,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0017076,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 2.7.13.3 ko:K00936 M00839 ko00000,ko00002,ko01000,ko01001,ko02022 Bacteria 2GKMP@201174,4EG9F@85012,COG3920@1,COG3920@2 NA|NA|NA T Histidine kinase MAG.T12.14_01923 1283283.ATXA01000002_gene2799 5.9e-36 156.4 Frankiales whiB GO:0000302,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0015035,GO:0015036,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042221,GO:0042493,GO:0045892,GO:0045934,GO:0047134,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0060255,GO:0065007,GO:0071731,GO:0080090,GO:0097159,GO:0097366,GO:1901363,GO:1901698,GO:1901700,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 ko:K18955 ko00000,ko03000 Bacteria 2DMIE@1,2IQCG@201174,32RSG@2,4ET35@85013 NA|NA|NA K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA MAG.T12.14_01924 1123320.KB889737_gene5367 1.1e-70 273.9 Actinobacteria Bacteria 2GJ3K@201174,COG1597@1,COG1597@2 NA|NA|NA I Diacylglycerol kinase MAG.T12.14_01926 222534.KB893670_gene3630 1.1e-89 337.0 Frankiales sigB GO:0000988,GO:0000990,GO:0003674,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0043620,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141 ko:K03090 ko00000,ko03021 Bacteria 2GKSY@201174,4ES7X@85013,COG1191@1,COG1191@2 NA|NA|NA K RNA polymerase MAG.T12.14_01927 500153.JOEK01000002_gene442 4e-23 114.4 Actinobacteria rshA 2.7.11.1 ko:K04757 ko00000,ko01000,ko01001,ko03021 Bacteria 2IFG9@201174,COG2172@1,COG2172@2 NA|NA|NA T anti-sigma regulatory factor MAG.T12.14_01928 1120959.ATXF01000011_gene239 2.4e-11 76.3 Microbacteriaceae 3.1.3.48 ko:K01104 ko00000,ko01000 Bacteria 2GMPR@201174,4FPK5@85023,COG0394@1,COG0394@2 NA|NA|NA T Low molecular weight phosphatase family MAG.T12.14_01929 649831.L083_3893 1.8e-106 393.3 Micromonosporales gba 3.2.1.45 ko:K01201 ko00511,ko00600,ko01100,ko04142,map00511,map00600,map01100,map04142 R01498 RC00059,RC00451 ko00000,ko00001,ko01000 GH30 Bacteria 2GMWN@201174,4D9UI@85008,COG5520@1,COG5520@2 NA|NA|NA G Glycosyl hydrolase family 30 beta sandwich domain MAG.T12.14_01930 1283287.KB822582_gene2986 1.1e-74 287.3 Actinobacteria Bacteria 2GP6W@201174,COG1835@1,COG1835@2 NA|NA|NA I Acyltransferase MAG.T12.14_01931 397278.JOJN01000007_gene3349 5.4e-137 495.0 Propionibacteriales ydaM Bacteria 2GNN5@201174,4DWKW@85009,COG1215@1,COG1215@2 NA|NA|NA M Glycosyl transferase family group 2 MAG.T12.14_01932 1077972.ARGLB_083_00470 3.2e-33 151.0 Actinobacteria Bacteria 2EIJM@1,2IREQ@201174,33CAY@2 NA|NA|NA MAG.T12.14_01933 1304865.JAGF01000001_gene125 7.8e-133 480.7 Actinobacteria Bacteria 2IA73@201174,COG1085@1,COG1085@2 NA|NA|NA C uridylyltransferase MAG.T12.14_01936 931627.MycrhDRAFT_2921 1.4e-242 845.9 Mycobacteriaceae fimV_2 ko:K19719 ko04151,ko04510,ko04512,ko04974,ko05165,map04151,map04510,map04512,map04974,map05165 ko00000,ko00001,ko00536 Bacteria 232WS@1762,2GJ7M@201174,COG0247@1,COG0247@2,COG3266@1,COG3266@2 NA|NA|NA C Fe-S oxidoreductase MAG.T12.14_01937 1136417.AZWE01000070_gene1255 1.7e-75 290.0 Micromonosporales GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0015562,GO:0022857,GO:0042221,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0055085 Bacteria 2HB3P@201174,4DCV1@85008,COG2271@1,COG2271@2 NA|NA|NA G PFAM major facilitator superfamily MFS_1 MAG.T12.14_01938 1304865.JAGF01000001_gene119 3.4e-155 555.4 Actinobacteria yvnB 3.1.4.53 ko:K03651 ko00230,ko02025,map00230,map02025 R00191 RC00296 ko00000,ko00001,ko01000 Bacteria 2GN7G@201174,COG1409@1,COG1409@2,COG3291@1,COG3291@2 NA|NA|NA P PFAM PKD domain containing protein MAG.T12.14_01939 367299.JOEE01000003_gene3004 1.4e-72 280.8 Actinobacteria Bacteria 2IT2M@201174,COG1807@1,COG1807@2 NA|NA|NA M Dolichyl-phosphate-mannose-protein mannosyltransferase MAG.T12.14_01940 263358.VAB18032_22820 2.7e-63 249.2 Micromonosporales wbbL_1 ko:K07011 ko00000 Bacteria 2HEV5@201174,4D9DN@85008,COG1216@1,COG1216@2 NA|NA|NA S Glycosyl transferase family group 2 MAG.T12.14_01941 110319.CF8_3325 4.4e-35 156.4 Bacteria 2.1.1.107,2.1.1.294,2.7.1.181,2.7.11.1 ko:K02496,ko:K05802,ko:K08884,ko:K18827 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03194,R10657,R10658 RC00002,RC00003,RC00078,RC00871,RC03220 ko00000,ko00001,ko00002,ko01000,ko01001,ko01005,ko02000 1.A.23.1.1 Bacteria COG2959@1,COG2959@2 NA|NA|NA H enzyme of heme biosynthesis MAG.T12.14_01942 1211815.CBYP010000024_gene1543 1.6e-122 446.0 Actinobacteria rgpA ko:K12996 ko00000,ko01000,ko01003,ko01005 GT4 Bacteria 2IBM0@201174,COG0438@1,COG0438@2 NA|NA|NA M Glycosyltransferase MAG.T12.14_01943 1173027.Mic7113_0392 2.8e-37 163.3 Cyanobacteria pslG ko:K21000 ko02025,map02025 ko00000,ko00001 GH39 Bacteria 1GANI@1117,COG3664@1,COG3664@2 NA|NA|NA G PFAM Glycosyl hydrolases family 39 MAG.T12.14_01944 1173027.Mic7113_0392 7.3e-42 178.3 Cyanobacteria pslG ko:K21000 ko02025,map02025 ko00000,ko00001 GH39 Bacteria 1GANI@1117,COG3664@1,COG3664@2 NA|NA|NA G PFAM Glycosyl hydrolases family 39 MAG.T12.14_01947 253839.SSNG_07182 3.8e-15 87.8 Actinobacteria Bacteria 2H714@201174,COG1484@1,COG1484@2 NA|NA|NA L PFAM IstB domain protein ATP-binding protein MAG.T12.14_01948 526226.Gbro_2584 1.5e-234 818.9 Gordoniaceae ko:K03733,ko:K04763 ko00000,ko03036 Bacteria 2IBD6@201174,4GFSJ@85026,COG4974@1,COG4974@2 NA|NA|NA L PFAM integrase family protein MAG.T12.14_01949 526226.Gbro_2585 5.7e-138 497.3 Gordoniaceae Bacteria 2I9ZX@201174,4GFWP@85026,COG4974@1,COG4974@2 NA|NA|NA L integrase domain protein SAM domain protein MAG.T12.14_01950 110319.CF8_4229 2.8e-132 478.4 Actinobacteria ko:K07497 ko00000 Bacteria 2GKDY@201174,COG2801@1,COG2801@2 NA|NA|NA L PFAM Integrase catalytic MAG.T12.14_01951 1121928.AUHE01000033_gene430 1e-199 702.6 Gordoniaceae insI1 GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004803,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0030983,GO:0032135,GO:0032196,GO:0032991,GO:0032993,GO:0034641,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 ko:K07482 ko00000 Bacteria 2GMZX@201174,4GASI@85026,COG2826@1,COG2826@2 NA|NA|NA L Transposase and inactivated derivatives IS30 family MAG.T12.14_01952 1169161.KB897713_gene6745 4.1e-17 94.0 Actinobacteria Bacteria 2BUP0@1,2HB4B@201174,32PZX@2 NA|NA|NA MAG.T12.14_01953 1169161.KB897713_gene6746 1.4e-22 113.2 Actinobacteria Bacteria 2APF8@1,2GVSP@201174,31VJ9@2 NA|NA|NA MAG.T12.14_01954 1121926.AXWO01000005_gene411 1.7e-20 105.5 Actinobacteria ko:K03892 ko00000,ko03000 Bacteria 2IRF0@201174,COG0640@1,COG0640@2 NA|NA|NA K helix_turn_helix, Arsenical Resistance Operon Repressor MAG.T12.14_01955 1121017.AUFG01000022_gene2176 5.5e-95 354.4 Intrasporangiaceae fieF Bacteria 2GJ8Q@201174,4FE8E@85021,COG0053@1,COG0053@2 NA|NA|NA P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family MAG.T12.14_01957 1214101.BN159_1336 6.9e-07 61.2 Actinobacteria Bacteria 2GTTI@201174,COG3976@1,COG3976@2 NA|NA|NA S FMN-binding domain protein MAG.T12.14_01959 58123.JOFJ01000012_gene5428 2.4e-41 176.0 Streptosporangiales apbE 2.7.1.180 ko:K03734 ko00000,ko01000 Bacteria 2GN6F@201174,4EPRS@85012,COG1477@1,COG1477@2 NA|NA|NA H ApbE family MAG.T12.14_01961 1283299.AUKG01000001_gene3534 1e-59 237.7 Rubrobacteria Bacteria 2GKWX@201174,4CRXT@84995,COG4097@1,COG4097@2 NA|NA|NA P FAD-binding domain MAG.T12.14_01963 1246995.AFR_11420 1.4e-36 159.8 Bacteria Bacteria 2E1Q9@1,32X0K@2 NA|NA|NA MAG.T12.14_01965 436229.JOEH01000017_gene6907 1.3e-67 262.7 Streptacidiphilus 2.3.1.128 ko:K01163,ko:K03790 ko00000,ko01000,ko03009 Bacteria 2H4AD@201174,2NKG7@228398,COG1670@1,COG1670@2 NA|NA|NA J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins MAG.T12.14_01966 2045.KR76_20720 1.6e-35 155.6 Propionibacteriales Bacteria 2IPEW@201174,4DS1Z@85009,COG1765@1,COG1765@2 NA|NA|NA O OsmC-like protein MAG.T12.14_01968 285535.JOEY01000026_gene9022 1.6e-59 236.9 Actinobacteria Bacteria 2GJEG@201174,COG4585@1,COG4585@2 NA|NA|NA T Histidine kinase MAG.T12.14_01969 285535.JOEY01000026_gene9021 1.2e-59 236.5 Actinobacteria Bacteria 2GJ46@201174,COG2197@1,COG2197@2 NA|NA|NA T response regulator MAG.T12.14_01970 1385520.N802_06105 1.3e-61 243.0 Actinobacteria Bacteria 2IFYE@201174,COG2197@1,COG2197@2 NA|NA|NA K helix_turn_helix, Lux Regulon MAG.T12.14_01971 1385520.N802_06110 2.7e-151 542.7 Actinobacteria degS Bacteria 2HDZV@201174,COG4585@1,COG4585@2 NA|NA|NA T Histidine kinase MAG.T12.14_01972 1385520.N802_06100 6.2e-34 150.6 Actinobacteria Bacteria 2E76N@1,2GRXJ@201174,338EF@2 NA|NA|NA MAG.T12.14_01973 1385520.N802_06095 1.5e-156 559.7 Actinobacteria Bacteria 2GMJ4@201174,COG2132@1,COG2132@2 NA|NA|NA Q Multicopper oxidase MAG.T12.14_01974 1027371.GOALK_026_00440 1.5e-57 229.6 Gordoniaceae Bacteria 2I51D@201174,4GF97@85026,COG3945@1,COG3945@2 NA|NA|NA S Hemerythrin HHE cation binding domain MAG.T12.14_01978 585529.HMPREF0291_11787 1.4e-24 119.8 Actinobacteria Bacteria 2DN7X@1,2IQJG@201174,32W0S@2 NA|NA|NA MAG.T12.14_01979 710696.Intca_3511 3.8e-72 278.1 Intrasporangiaceae 3.6.1.55 ko:K03574 ko00000,ko01000,ko03400 Bacteria 2IJP8@201174,4FF1N@85021,COG4923@1,COG4923@2 NA|NA|NA K Protein of unknown function (DUF429) MAG.T12.14_01980 1246995.AFR_03310 1.5e-11 75.9 Micromonosporales Bacteria 2GJKC@201174,4DBA8@85008,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor MAG.T12.14_01981 1463903.JOIZ01000010_gene3653 1.1e-52 213.4 Actinobacteria Bacteria 2GJ2N@201174,COG0745@1,COG0745@2 NA|NA|NA T response regulator, receiver MAG.T12.14_01982 1304865.JAGF01000001_gene3499 2.2e-102 379.0 Actinobacteria corA ko:K03284 ko00000,ko02000 1.A.35.1,1.A.35.3 Bacteria 2IB0N@201174,COG0598@1,COG0598@2 NA|NA|NA P PFAM Mg2 transporter protein CorA family protein MAG.T12.14_01983 446465.Bfae_27530 7.6e-79 301.2 Dermabacteraceae yqhO GO:0003674,GO:0003824,GO:0016787 ko:K07001 ko00000 Bacteria 2IA6V@201174,4FC03@85020,COG1752@1,COG1752@2 NA|NA|NA S Patatin-like phospholipase MAG.T12.14_01984 479431.Namu_0355 9.7e-10 68.2 Actinobacteria Bacteria 2EGTM@1,2GWY1@201174,33AJR@2 NA|NA|NA MAG.T12.14_01985 1121946.AUAX01000005_gene5163 8.1e-59 234.6 Micromonosporales Bacteria 2GIR7@201174,4D95J@85008,COG4129@1,COG4129@2 NA|NA|NA S Evidence 4 Homologs of previously reported genes of MAG.T12.14_01986 1394178.AWOO02000024_gene5655 7.8e-27 128.6 Streptosporangiales Bacteria 2HV9N@201174,4EINQ@85012,COG5555@1,COG5555@2 NA|NA|NA N Belongs to the peptidase S8 family MAG.T12.14_01987 1435356.Y013_11045 1.5e-95 357.1 Nocardiaceae phoR 2.7.13.3 ko:K02484,ko:K07768 ko02020,map02020 M00443 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 2I2DU@201174,4FTXC@85025,COG5002@1,COG5002@2 NA|NA|NA T His Kinase A (phosphoacceptor) domain MAG.T12.14_01988 1380356.JNIK01000018_gene799 1.6e-94 352.4 Frankiales Bacteria 2GIZB@201174,4ERG0@85013,COG0745@1,COG0745@2 NA|NA|NA T Two component transcriptional regulator, winged helix family MAG.T12.14_01989 675635.Psed_5033 2.5e-144 518.8 Pseudonocardiales ko:K07015 ko00000 Bacteria 2GJTE@201174,4DYC7@85010,COG1215@1,COG1215@2,COG2246@1,COG2246@2 NA|NA|NA M GtrA-like protein MAG.T12.14_01990 37919.EP51_17595 3.5e-183 648.7 Nocardiaceae Bacteria 2GJPU@201174,4FTWD@85025,COG1807@1,COG1807@2 NA|NA|NA M Dolichyl-phosphate-mannose-protein mannosyltransferase MAG.T12.14_01992 1121017.AUFG01000013_gene1927 6.9e-188 664.1 Intrasporangiaceae feoB ko:K04759 ko00000,ko02000 9.A.8.1 Bacteria 2GTV2@201174,4FIUH@85021,COG0370@1,COG0370@2 NA|NA|NA P Ferrous iron transport protein B C terminus MAG.T12.14_01994 1192759.AKIB01000096_gene1609 1.5e-37 162.9 Sphingomonadales ogt 1.17.99.6,2.1.1.63 ko:K00567,ko:K18979 ko00000,ko01000,ko03016,ko03400 Bacteria 1N2YQ@1224,2KD23@204457,2TRRN@28211,COG0350@1,COG0350@2 NA|NA|NA L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated MAG.T12.14_01995 1237500.ANBA01000033_gene4471 7.2e-145 520.8 Streptosporangiales ada 3.2.2.21 ko:K13529,ko:K15051 ko03410,map03410 ko00000,ko00001,ko01000,ko03000,ko03400 Bacteria 2GITG@201174,4EGE3@85012,COG0122@1,COG0122@2,COG2169@1,COG2169@2 NA|NA|NA FL AlkA N-terminal domain MAG.T12.14_01996 2002.JOEQ01000005_gene3672 7.5e-185 654.1 Streptosporangiales Bacteria 2I3HX@201174,4EHKS@85012,COG0421@1,COG0421@2 NA|NA|NA E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine MAG.T12.14_01997 1125863.JAFN01000001_gene2799 8.3e-35 153.3 Deltaproteobacteria tesC GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0047617,GO:0055114,GO:0071704,GO:0072329,GO:1901575 ko:K07107,ko:K12500 ko00000,ko01000,ko01004 Bacteria 1REIH@1224,2WQAZ@28221,42UZ3@68525,COG0824@1,COG0824@2 NA|NA|NA S Thioesterase-like superfamily MAG.T12.14_01998 404589.Anae109_2437 7.9e-13 80.5 Myxococcales ko:K04767,ko:K07168,ko:K07182 ko00000 Bacteria 1N0EB@1224,2WRIB@28221,2YVSI@29,42W96@68525,COG0517@1,COG0517@2 NA|NA|NA S CBS domain MAG.T12.14_01999 1463856.JOHY01000007_gene716 1.5e-67 262.7 Actinobacteria orn GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360 ko:K13288 ko03008,map03008 ko00000,ko00001,ko01000,ko03009,ko03019 Bacteria 2GJR7@201174,COG1949@1,COG1949@2 NA|NA|NA L 3'-to-5' exoribonuclease specific for small oligoribonucleotides MAG.T12.14_02001 1504319.GM45_6105 8.5e-97 359.8 unclassified Actinobacteria (class) atpD GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 Bacteria 2GIY6@201174,3UW86@52018,COG0055@1,COG0055@2 NA|NA|NA C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits MAG.T12.14_02002 566461.SSFG_02307 1.1e-23 116.3 Actinobacteria atpC GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 Bacteria 2IHNZ@201174,COG0355@1,COG0355@2 NA|NA|NA C Produces ATP from ADP in the presence of a proton gradient across the membrane MAG.T12.14_02003 1144275.COCOR_04546 3.2e-61 242.7 Bacteria Bacteria COG2273@1,COG2273@2 NA|NA|NA G xyloglucan:xyloglucosyl transferase activity MAG.T12.14_02004 1996.JOFO01000033_gene1260 3.2e-77 295.8 Actinobacteria Bacteria 2GKTW@201174,COG1216@1,COG1216@2 NA|NA|NA M Glycosyl transferase family 2 MAG.T12.14_02005 1089544.KB912942_gene1730 5.9e-78 298.1 Pseudonocardiales Bacteria 2I92N@201174,4DXBA@85010,COG3664@1,COG3664@2 NA|NA|NA G PFAM glycoside hydrolase family 39 MAG.T12.14_02006 797302.Halru_2865 6e-09 68.9 Halobacteria Archaea 23U89@183963,2XUFQ@28890,COG3919@1,arCOG06897@2157 NA|NA|NA S COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ) MAG.T12.14_02007 526225.Gobs_0437 7.3e-45 188.3 Frankiales Bacteria 2GMYJ@201174,4EVNC@85013,COG2244@1,COG2244@2 NA|NA|NA S polysaccharide biosynthetic process MAG.T12.14_02010 58344.JOEL01000006_gene4701 3.4e-56 226.5 Actinobacteria Bacteria 2GMYJ@201174,COG2244@1,COG2244@2 NA|NA|NA G outer membrane autotransporter barrel domain protein MAG.T12.14_02011 543632.JOJL01000008_gene5609 4.1e-85 321.6 Micromonosporales exoM Bacteria 2GKTW@201174,4DIHT@85008,COG1216@1,COG1216@2 NA|NA|NA S Glycosyltransferase like family 2 MAG.T12.14_02012 1268303.RHODMAR_0120 1e-75 290.4 Nocardiaceae Bacteria 2GP1D@201174,4G9DV@85025,COG1215@1,COG1215@2 NA|NA|NA M Glycosyltransferase like family 2 MAG.T12.14_02013 585531.HMPREF0063_12237 1.1e-66 259.6 Propionibacteriales yvqK 2.5.1.17 ko:K00798 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 Bacteria 2GMHN@201174,4DNZ5@85009,COG2096@1,COG2096@2 NA|NA|NA S Cobalamin adenosyltransferase MAG.T12.14_02014 1146883.BLASA_3913 5.2e-160 570.9 Frankiales murA GO:0008150,GO:0040007 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 R00660 RC00350 ko00000,ko00001,ko01000,ko01011 Bacteria 2GJPW@201174,4ERJ6@85013,COG0766@1,COG0766@2 NA|NA|NA M Belongs to the EPSP synthase family. MurA subfamily MAG.T12.14_02015 1123320.KB889698_gene9326 3e-100 371.7 Actinobacteria hbd 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 Bacteria 2GJBM@201174,COG1250@1,COG1250@2 NA|NA|NA I 3-hydroxyacyl-CoA dehydrogenase MAG.T12.14_02016 367299.JOEE01000004_gene1007 6e-272 943.3 Intrasporangiaceae meaA 5.4.99.63 ko:K14447 ko00630,ko01120,ko01200,map00630,map01120,map01200 M00373 R09292 RC02835 ko00000,ko00001,ko00002,ko01000 Bacteria 2I2N3@201174,4FEHX@85021,COG2185@1,COG2185@2 NA|NA|NA I Methylmalonyl-CoA mutase MAG.T12.14_02017 1454010.JEOE01000017_gene1266 8e-74 283.9 Cellulomonadaceae ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GN6S@201174,4F0I9@85016,COG0842@1,COG0842@2 NA|NA|NA V PFAM ABC-2 type transporter MAG.T12.14_02018 1211815.CBYP010000045_gene812 2.6e-99 368.6 Frankiales ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GJBF@201174,4EUKR@85013,COG1131@1,COG1131@2 NA|NA|NA V AAA domain, putative AbiEii toxin, Type IV TA system MAG.T12.14_02019 477641.MODMU_4528 4e-95 354.4 Frankiales nucS ko:K07503 ko00000,ko01000 Bacteria 2GIYB@201174,4ES1R@85013,COG1637@1,COG1637@2 NA|NA|NA L Cleaves both 3' and 5' ssDNA extremities of branched DNA structures MAG.T12.14_02020 1380370.JIBA01000014_gene2048 2.9e-217 761.5 Intrasporangiaceae 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 Bacteria 2GJBM@201174,4FEPZ@85021,COG1250@1,COG1250@2 NA|NA|NA I Dehydrogenase MAG.T12.14_02021 33876.JNXY01000008_gene8430 4.4e-74 284.6 Micromonosporales ko:K07018 ko00000 Bacteria 2GP8G@201174,4DCBM@85008,COG2945@1,COG2945@2 NA|NA|NA S hydrolase of the alpha beta MAG.T12.14_02022 446470.Snas_1605 5.5e-23 113.2 Glycomycetales Bacteria 2E3EP@1,2GQST@201174,32YDP@2,4EZ3F@85014 NA|NA|NA S ATP- GTP-binding protein MAG.T12.14_02023 1894.JOER01000013_gene1059 2.9e-59 235.3 Actinobacteria mazG GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0022607,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0035539,GO:0042454,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044464,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0047693,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.6.1.66 ko:K02428 ko00230,map00230 R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 Bacteria 2GNKC@201174,COG1694@1,COG3956@2 NA|NA|NA S PFAM MazG nucleotide pyrophosphohydrolase MAG.T12.14_02025 1907.SGLAU_14165 0.0 1521.9 Actinobacteria mfd ko:K03723 ko03420,map03420 ko00000,ko00001,ko01000,ko03400 Bacteria 2GJ42@201174,COG1197@1,COG1197@2 NA|NA|NA L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site MAG.T12.14_02026 1123393.KB891316_gene1793 3.7e-143 515.8 Betaproteobacteria Bacteria 1MU2C@1224,2VH3V@28216,COG5001@1,COG5001@2 NA|NA|NA T Diguanylate cyclase MAG.T12.14_02027 350058.Mvan_3479 6.1e-42 177.9 Mycobacteriaceae cysQ GO:0000103,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008441,GO:0008934,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016020,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019637,GO:0019693,GO:0030145,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042132,GO:0042578,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050308,GO:0050427,GO:0050897,GO:0052745,GO:0052834,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564 3.1.3.7 ko:K01082 ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130 R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03016 Bacteria 232H4@1762,2GMW7@201174,COG1218@1,COG1218@2 NA|NA|NA P Inositol monophosphatase MAG.T12.14_02028 1120950.KB892752_gene6143 6.6e-62 243.8 Propionibacteriales pth GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016787,GO:0016788,GO:0040007,GO:0044464,GO:0052689,GO:0071944,GO:0140098,GO:0140101 3.1.1.29 ko:K01056 ko00000,ko01000,ko03012 Bacteria 2GKCV@201174,4DPFB@85009,COG0193@1,COG0193@2 NA|NA|NA J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis MAG.T12.14_02029 446466.Cfla_0883 6.2e-22 110.9 Cellulomonadaceae ctc GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02897 ko03010,map03010 M00178 ko00000,ko00001,ko00002,ko03011 Bacteria 2GJPJ@201174,4F160@85016,COG1825@1,COG1825@2 NA|NA|NA J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance MAG.T12.14_02030 1227487.C474_12461 1.7e-165 589.7 Halobacteria treZ 2.4.1.18,3.2.1.141 ko:K00700,ko:K01236 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110,R09995,R11256 RC00049 ko00000,ko00001,ko00002,ko01000,ko04147 CBM48,GH13 Archaea 23ZEB@183963,2Y0XG@28890,COG0296@1,arCOG02951@2157 NA|NA|NA G Alpha amylase, catalytic domain MAG.T12.14_02031 1504319.GM45_3005 2.9e-131 474.9 unclassified Actinobacteria (class) prs GO:0000287,GO:0003674,GO:0003824,GO:0004749,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006015,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0046390,GO:0046391,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901576 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ9S@201174,3UW77@52018,COG0462@1,COG0462@2 NA|NA|NA F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) MAG.T12.14_02032 28042.GU90_04150 1.2e-155 556.6 Pseudonocardiales glmU GO:0000270,GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0005975,GO:0005976,GO:0006022,GO:0006023,GO:0006024,GO:0006629,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009252,GO:0009273,GO:0009987,GO:0016051,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0019134,GO:0022610,GO:0030203,GO:0030260,GO:0033692,GO:0034637,GO:0034645,GO:0035635,GO:0040007,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044650,GO:0046872,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0070569,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1903509 2.3.1.157,2.7.7.23 ko:K04042,ko:K11528,ko:K16203 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000,ko01002 3.A.1.5.2 iJN678.glmU,iLJ478.TM1629 Bacteria 2GJS1@201174,4DZZ7@85010,COG1207@1,COG1207@2 NA|NA|NA M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain MAG.T12.14_02034 1123320.KB889688_gene428 1.3e-57 229.6 Actinobacteria icaR Bacteria 2GMBW@201174,COG1309@1,COG1309@2 NA|NA|NA K transcriptional regulator MAG.T12.14_02035 593907.Celgi_0587 6.2e-52 210.7 Cellulomonadaceae pecS Bacteria 2GJ6W@201174,4F19N@85016,COG1846@1,COG1846@2 NA|NA|NA K PFAM regulatory protein MarR MAG.T12.14_02036 929712.KI912613_gene4331 2.1e-173 615.9 Rubrobacteria yjjK ko:K15738 ko00000,ko02000 3.A.1.120.6 Bacteria 2GJ5M@201174,4CRTW@84995,COG0488@1,COG0488@2 NA|NA|NA S ABC transporter MAG.T12.14_02037 1304865.JAGF01000001_gene92 7.7e-60 237.7 Actinobacteria manA 5.3.1.8 ko:K01809 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01819 RC00376 ko00000,ko00001,ko00002,ko01000 Bacteria 2I8X4@201174,COG1482@1,COG1482@2 NA|NA|NA G mannose-6-phosphate isomerase MAG.T12.14_02038 446471.Xcel_2724 7.4e-76 290.8 Promicromonosporaceae ispE GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006629,GO:0006720,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0050515,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901576 2.1.1.182,2.7.1.148 ko:K00919,ko:K02528,ko:K16924 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096,M00582 R05634,R10716 RC00002,RC00003,RC01439,RC03257 ko00000,ko00001,ko00002,ko01000,ko02000,ko03009 3.A.1.29 iEC55989_1330.EC55989_1304,iLJ478.TM1383,iYO844.BSU00460 Bacteria 2GKXD@201174,4F3UP@85017,COG1947@1,COG1947@2 NA|NA|NA I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol MAG.T12.14_02039 1032480.MLP_27790 7.1e-88 331.3 Propionibacteriales Bacteria 2GP0C@201174,4DS7R@85009,COG1409@1,COG1409@2 NA|NA|NA S Calcineurin-like phosphoesterase MAG.T12.14_02040 67257.JODR01000011_gene5452 5.9e-88 330.9 Actinobacteria ksgA GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 ko:K02528 R10716 RC00003,RC03257 ko00000,ko01000,ko03009 Bacteria 2GKBT@201174,COG0030@1,COG0030@2 NA|NA|NA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits MAG.T12.14_02041 1120958.AULD01000007_gene979 2.6e-41 174.9 Microbacteriaceae tatD ko:K03424 ko00000,ko01000 Bacteria 2GMJJ@201174,4FKYS@85023,COG0084@1,COG0084@2 NA|NA|NA L TatD related DNase MAG.T12.14_02043 1194165.CAJF01000007_gene661 6.3e-77 293.5 Microbacteriaceae ilvN GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0030312,GO:0032991,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 iECO103_1326.ilvN,iJN678.ilvN Bacteria 2GJCH@201174,4FM2D@85023,COG0440@1,COG0440@2 NA|NA|NA E ACT domain MAG.T12.14_02044 1713.JOFV01000012_gene806 5.1e-259 900.2 Cellulomonadaceae ilvB 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKU4@201174,4F0HH@85016,COG0028@1,COG0028@2 NA|NA|NA E TIGRFAM acetolactate synthase, large subunit, biosynthetic type MAG.T12.14_02045 1122236.KB905144_gene2309 4.8e-123 448.7 Nitrosomonadales Bacteria 1MU2C@1224,2KNM3@206350,2VIDG@28216,COG5001@1,COG5001@2 NA|NA|NA T Putative diguanylate phosphodiesterase MAG.T12.14_02046 1120950.KB892741_gene2670 5.4e-258 896.7 Propionibacteriales ilvD GO:0003674,GO:0003824,GO:0004160,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJIJ@201174,4DNV7@85009,COG0129@1,COG0129@2 NA|NA|NA EG Belongs to the IlvD Edd family MAG.T12.14_02047 1121946.AUAX01000019_gene7777 9.7e-63 246.9 Actinobacteria Bacteria 2ISWE@201174,COG3340@1,COG3340@2 NA|NA|NA E Peptidase family S51 MAG.T12.14_02048 351607.Acel_2052 5.8e-65 255.0 Actinobacteria 3.4.13.21,3.4.15.6 ko:K05995,ko:K13282 R09722 RC00064,RC00141 ko00000,ko01000,ko01002 Bacteria 2I98G@201174,COG0215@1,COG0215@2,COG4242@1,COG4242@2 NA|NA|NA J Belongs to the peptidase S51 family MAG.T12.14_02049 1463825.JNXC01000005_gene2483 2.9e-49 201.8 Pseudonocardiales bioY ko:K02014,ko:K03523 ko02010,map02010 M00581,M00582 ko00000,ko00001,ko00002,ko02000 1.B.14,2.A.88.1,2.A.88.2 Bacteria 2GJ53@201174,4E2ZE@85010,COG1268@1,COG1268@2 NA|NA|NA S BioY family MAG.T12.14_02050 1032480.MLP_29440 1e-207 729.6 Propionibacteriales gatB GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 Bacteria 2GJJH@201174,4DNB4@85009,COG0064@1,COG0064@2 NA|NA|NA J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) MAG.T12.14_02051 235985.BBPN01000056_gene7833 2.4e-217 761.5 Streptacidiphilus gatA 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 Bacteria 2GJK5@201174,2NHY5@228398,COG0154@1,COG0154@2 NA|NA|NA J Amidase MAG.T12.14_02052 1122182.KB903834_gene5703 3.4e-25 120.9 Micromonosporales gatC GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 Bacteria 2IQJN@201174,4DEPX@85008,COG0721@1,COG0721@2 NA|NA|NA J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) MAG.T12.14_02053 266940.Krad_1315 2.3e-227 795.4 Actinobacteria ligA GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016874,GO:0016886,GO:0030312,GO:0033554,GO:0034641,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 Bacteria 2GJUY@201174,COG0272@1,COG0272@2 NA|NA|NA L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA MAG.T12.14_02054 981369.JQMJ01000004_gene5729 9.6e-61 240.7 Streptacidiphilus 2.1.1.14 ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R04405,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 Bacteria 2GMPS@201174,2NF4D@228398,COG0620@1,COG0620@2 NA|NA|NA E Cobalamin-independent synthase, Catalytic domain MAG.T12.14_02055 1122919.KB905604_gene4558 9.7e-82 310.5 Paenibacillaceae ygjR GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0055114,GO:0102497 ko:K22230 ko00562,ko01120,map00562,map01120 R09954 RC00182 ko00000,ko00001,ko01000 Bacteria 1TQSS@1239,26SCY@186822,4HCIG@91061,COG0673@1,COG0673@2 NA|NA|NA S Oxidoreductase MAG.T12.14_02056 1172188.KB911821_gene1287 1.1e-15 89.4 Intrasporangiaceae Bacteria 2E45J@1,2GR89@201174,32Z1K@2,4FHGH@85021 NA|NA|NA S Branched-chain amino acid transport protein (AzlD) MAG.T12.14_02057 1123251.ATWM01000001_gene699 1.3e-43 183.3 Intrasporangiaceae Bacteria 2GN6R@201174,4FFT4@85021,COG1296@1,COG1296@2 NA|NA|NA E branched-chain amino acid MAG.T12.14_02058 452652.KSE_51040 2.9e-132 478.4 Kitasatospora mnmA 2.8.1.13 ko:K00566 ko04122,map04122 R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 Bacteria 2GIUQ@201174,2M13X@2063,COG0482@1,COG0482@2 NA|NA|NA J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 MAG.T12.14_02059 1348663.KCH_51370 2e-121 442.6 Kitasatospora iscS GO:0003674,GO:0003824,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0016783,GO:0022607,GO:0031071,GO:0031163,GO:0040007,GO:0044085,GO:0044237,GO:0051186,GO:0071840 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 Bacteria 2GKUT@201174,2M12X@2063,COG1104@1,COG1104@2 NA|NA|NA E Beta-eliminating lyase MAG.T12.14_02060 469371.Tbis_2845 1.8e-59 235.3 Pseudonocardiales etfA GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 ko:K03522 ko00000,ko04147 Bacteria 2GJWH@201174,4DY2C@85010,COG2025@1,COG2025@2 NA|NA|NA C Electron transfer flavoprotein alpha subunit MAG.T12.14_02061 1343740.M271_17085 5.7e-48 198.0 Actinobacteria atpH ko:K02109,ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 Bacteria 2GMJ5@201174,COG0712@1,COG0712@2 NA|NA|NA C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation MAG.T12.14_02062 1122175.ATXU01000001_gene931 5.5e-34 151.0 Microbacteriaceae atpF ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 Bacteria 2GJS4@201174,4FNEE@85023,COG0711@1,COG0711@2 NA|NA|NA C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) MAG.T12.14_02063 1504319.GM45_6080 1.5e-27 128.3 unclassified Actinobacteria (class) atpE GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 Bacteria 2HGDC@201174,3UWZI@52018,COG0636@1,COG0636@2 NA|NA|NA C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation MAG.T12.14_02064 1504319.GM45_6075 1.7e-68 266.2 unclassified Actinobacteria (class) atpB ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 Bacteria 2H3PR@201174,3UWN7@52018,COG0356@1,COG0356@2 NA|NA|NA C it plays a direct role in the translocation of protons across the membrane MAG.T12.14_02065 1504319.GM45_6070 7.2e-14 83.2 Bacteria Bacteria 2972E@1,2ZUAS@2 NA|NA|NA MAG.T12.14_02066 1713.JOFV01000002_gene496 1.1e-10 73.2 Cellulomonadaceae atpI ko:K02116 ko00000,ko00194 3.A.2.1 Bacteria 2BJAR@1,2GR4T@201174,32DKN@2,4F1BV@85016 NA|NA|NA MAG.T12.14_02067 1504319.GM45_6060 2.6e-91 342.4 unclassified Actinobacteria (class) tagO GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0034645,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0045229,GO:0046872,GO:0046914,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:1901576 2.7.8.33,2.7.8.35 ko:K02851 R08856 RC00002 ko00000,ko01000,ko01003,ko01005 Bacteria 2GIT7@201174,3UWGE@52018,COG0472@1,COG0472@2 NA|NA|NA M Glycosyl transferase family 4 MAG.T12.14_02068 1146883.BLASA_3927 2.2e-187 661.8 Frankiales glyA 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 Bacteria 2GK7U@201174,4ERC5@85013,COG0112@1,COG0112@2 NA|NA|NA E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism MAG.T12.14_02069 222534.KB893751_gene4143 1.2e-40 173.3 Frankiales ywlC GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 2.7.7.87 ko:K07566 R10463 RC00745 ko00000,ko01000,ko03009,ko03016 Bacteria 2GK2X@201174,4ESEK@85013,COG0009@1,COG0009@2 NA|NA|NA J Belongs to the SUA5 family MAG.T12.14_02070 1120950.KB892745_gene2866 6.4e-67 261.2 Propionibacteriales prmC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464 2.1.1.297 ko:K02493 R10806 RC00003,RC03279 ko00000,ko01000,ko03012 Bacteria 2GMH1@201174,4DP23@85009,COG2890@1,COG2890@2 NA|NA|NA J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif MAG.T12.14_02071 1449353.JQMQ01000005_gene2192 8.7e-137 493.4 Streptacidiphilus prfA ko:K02835 ko00000,ko03012 Bacteria 2GJWG@201174,2NGSW@228398,COG0216@1,COG0216@2 NA|NA|NA J PCRF MAG.T12.14_02072 471852.Tcur_3932 1.3e-28 131.7 Streptosporangiales rpmE ko:K02909 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IQ4I@201174,4EK8U@85012,COG0254@1,COG0254@2 NA|NA|NA J Binds the 23S rRNA MAG.T12.14_02073 1449069.JMLO01000004_gene3655 2.8e-123 448.7 Nocardiaceae proP Bacteria 2I2EY@201174,4G9I9@85025,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily MAG.T12.14_02074 1048339.KB913029_gene3381 6.2e-183 647.5 Frankiales rho GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006360,GO:0006363,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 ko:K03628 ko03018,map03018 ko00000,ko00001,ko03019,ko03021 Bacteria 2GIWY@201174,4ERDG@85013,COG1158@1,COG1158@2 NA|NA|NA K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template MAG.T12.14_02075 593907.Celgi_2478 3.7e-67 261.9 Cellulomonadaceae thrB GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.1.39 ko:K00872 ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 M00018 R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 iECSE_1348.ECSE_0003,iJN678.thrB,iLJ478.TM0545,iSB619.SA_RS06620 Bacteria 2GKIW@201174,4F0RU@85016,COG0083@1,COG0083@2 NA|NA|NA E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate MAG.T12.14_02076 1463920.JOGB01000028_gene5208 5.6e-139 500.7 Actinobacteria thrC GO:0003674,GO:0003824,GO:0004795,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 iLJ478.TM0546,iSB619.SA_RS06615,iYO844.BSU32250 Bacteria 2GJ5F@201174,COG0498@1,COG0498@2 NA|NA|NA E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine MAG.T12.14_02077 222534.KB893751_gene4136 3.9e-131 474.9 Frankiales hom GO:0003674,GO:0003824,GO:0004412,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1294,iSB619.SA_RS06610 Bacteria 2GIX9@201174,4ERJB@85013,COG0460@1,COG0460@2 NA|NA|NA E homoserine dehydrogenase MAG.T12.14_02078 1211815.CBYP010000042_gene2347 9.9e-160 570.1 Frankiales lysA 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKAI@201174,4ERM5@85013,COG0019@1,COG0019@2 NA|NA|NA E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine MAG.T12.14_02079 2074.JNYD01000014_gene7070 3.1e-16 92.8 Pseudonocardiales ko:K07058 ko00000 Bacteria 2GM6P@201174,4E0J5@85010,COG1295@1,COG1295@2 NA|NA|NA S Virulence factor BrkB MAG.T12.14_02080 351607.Acel_0628 6.2e-206 723.8 Frankiales argS GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 iAF987.Gmet_1434 Bacteria 2GKQ3@201174,4ERR2@85013,COG0018@1,COG0018@2 NA|NA|NA J Arginyl-tRNA synthetase MAG.T12.14_02082 100226.SCO3153 2.8e-88 332.0 Actinobacteria rsmI GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.198 ko:K07056 ko00000,ko01000,ko03009 Bacteria 2GJ9Q@201174,COG0313@1,COG0313@2 NA|NA|NA H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA MAG.T12.14_02083 1123321.KB905830_gene755 5.5e-132 478.0 Actinobacteria pmt 2.4.1.109 ko:K00728 ko00514,ko00515,ko01100,map00514,map00515,map01100 R04072,R07620,R11399 RC00005,RC00059,RC00397 ko00000,ko00001,ko01000,ko01003 GT39 Bacteria 2I2H1@201174,COG1928@1,COG1928@2 NA|NA|NA O PFAM glycosyl transferase family 39 MAG.T12.14_02084 1112204.GPOL_c41030 6.2e-109 401.4 Gordoniaceae Bacteria 2GKU0@201174,4GD5R@85026,COG1020@1,COG1020@2 NA|NA|NA Q Protein of unknown function (DUF1298) MAG.T12.14_02088 1123322.KB904676_gene3086 3e-60 238.4 Actinobacteria rimJ 2.3.1.128 ko:K03790 ko00000,ko01000,ko03009 Bacteria 2HAFI@201174,COG1670@1,COG1670@2 NA|NA|NA J N-acetyltransferase MAG.T12.14_02089 351607.Acel_0167 2.6e-105 389.0 Frankiales moeA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0018315,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0032324,GO:0034641,GO:0036211,GO:0042040,GO:0042278,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0061599,GO:0070566,GO:0071704,GO:0071944,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 R09735 RC03462 ko00000,ko00001,ko01000 Bacteria 2GJC3@201174,4ERWC@85013,COG0303@1,COG0303@2 NA|NA|NA H MoeA domain protein domain I and II MAG.T12.14_02090 593907.Celgi_0566 1.6e-94 352.8 Actinobacteria galU GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0003983,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005996,GO:0006011,GO:0006012,GO:0006073,GO:0006139,GO:0006629,GO:0006725,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009056,GO:0009058,GO:0009059,GO:0009103,GO:0009225,GO:0009242,GO:0009244,GO:0009250,GO:0009311,GO:0009312,GO:0009987,GO:0016043,GO:0016051,GO:0016052,GO:0016740,GO:0016772,GO:0016779,GO:0019318,GO:0019320,GO:0019388,GO:0022607,GO:0033499,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043933,GO:0044042,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046377,GO:0046401,GO:0046483,GO:0046872,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051748,GO:0055086,GO:0065003,GO:0070569,GO:0071704,GO:0071840,GO:1900725,GO:1900727,GO:1901135,GO:1901137,GO:1901360,GO:1901575,GO:1901576,GO:1903509 2.7.7.9,5.4.2.8 ko:K00963,ko:K01840 ko00040,ko00051,ko00052,ko00500,ko00520,ko01100,ko01110,ko01130,map00040,map00051,map00052,map00500,map00520,map01100,map01110,map01130 M00114,M00129,M00361,M00362,M00549 R00289,R01818 RC00002,RC00408 ko00000,ko00001,ko00002,ko01000 iECIAI39_1322.ECIAI39_1571,iHN637.CLJU_RS02205,iIT341.HP0646 Bacteria 2I2EW@201174,COG1210@1,COG1210@2 NA|NA|NA M Utp--glucose-1-phosphate uridylyltransferase MAG.T12.14_02091 465515.Mlut_16430 2.4e-30 139.0 Micrococcaceae fthC 6.3.3.2 ko:K01934 ko00670,ko01100,map00670,map01100 R02301 RC00183 ko00000,ko00001,ko01000 Bacteria 1W9K2@1268,2IKWR@201174,COG0212@1,COG0212@2 NA|NA|NA H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family MAG.T12.14_02092 350058.Mvan_4835 2.6e-18 98.2 Mycobacteriaceae fmdB Bacteria 23AJP@1762,2IQHE@201174,COG2331@1,COG2331@2 NA|NA|NA S regulatory protein, FmdB family MAG.T12.14_02093 1245475.ANAE01000105_gene2691 5.2e-23 114.8 Streptosporangiales cpaB ko:K02279 ko00000,ko02035,ko02044 Bacteria 2GQJH@201174,4EKC2@85012,COG3745@1,COG3745@2 NA|NA|NA U SAF MAG.T12.14_02094 1235801.C822_02013 5.5e-20 104.0 Lactobacillaceae mscL GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066 ko:K03282 ko00000,ko02000 1.A.22.1 Bacteria 1VA14@1239,3F6YZ@33958,4HKIA@91061,COG1970@1,COG1970@2 NA|NA|NA M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell MAG.T12.14_02096 1121272.KB903255_gene5793 1.6e-67 263.1 Micromonosporales pac ko:K07184 ko00000 Bacteria 2I2N7@201174,4DBJV@85008,COG1938@1,COG1938@2 NA|NA|NA S PAC2 family MAG.T12.14_02097 134676.ACPL_5559 2.3e-28 134.0 Actinobacteria Bacteria 2IR52@201174,COG1525@1,COG1525@2 NA|NA|NA L Lamin Tail Domain MAG.T12.14_02098 479435.Kfla_5917 3.8e-154 551.6 Propionibacteriales yjcD GO:0003674,GO:0005215,GO:0005345,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006863,GO:0008150,GO:0015205,GO:0015208,GO:0015851,GO:0015854,GO:0016020,GO:0022857,GO:0035344,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:0098657,GO:0098710,GO:0098739,GO:1903716,GO:1904823 ko:K06901 ko00000,ko02000 2.A.1.40 Bacteria 2GKYD@201174,4DNIA@85009,COG2252@1,COG2252@2 NA|NA|NA S Permease family MAG.T12.14_02099 266940.Krad_1273 8.8e-11 73.2 Actinobacteria Bacteria 2E3JG@1,2GU6T@201174,32YHV@2 NA|NA|NA MAG.T12.14_02100 446471.Xcel_3125 2.6e-136 491.9 Actinobacteria pqqE ko:K22227 ko00000 Bacteria 2GNSY@201174,COG0535@1,COG0535@2 NA|NA|NA C Radical SAM MAG.T12.14_02101 1035308.AQYY01000001_gene3069 5.4e-123 448.0 Clostridia hemG 1.3.3.15,1.3.3.4 ko:K00231 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03222,R04178 RC00885 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQ6W@1239,24IHQ@186801,COG1232@1,COG1232@2 NA|NA|NA H Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX MAG.T12.14_02103 1227261.HMPREF0043_00810 3.9e-07 60.8 Actinobacteria Bacteria 2GITW@201174,4D39J@85005,COG1167@1,COG1167@2 NA|NA|NA EK Aminotransferase, class I II MAG.T12.14_02105 1283299.AUKG01000001_gene3305 5.7e-77 295.0 Actinobacteria 4.6.1.1 ko:K01768,ko:K17763 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000,ko03021 Bacteria 2IIRA@201174,COG2200@1,COG2200@2,COG2203@1,COG2203@2 NA|NA|NA T PFAM EAL domain protein MAG.T12.14_02106 1298863.AUEP01000012_gene3726 4.2e-54 218.4 Propionibacteriales tsnR 2.1.1.185 ko:K03218,ko:K03437 ko00000,ko01000,ko03009,ko03016 Bacteria 2GJI6@201174,4DQ6Y@85009,COG0566@1,COG0566@2 NA|NA|NA J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family MAG.T12.14_02107 1307761.L21SP2_0103 1.4e-114 420.2 Spirochaetes GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.2.1.1 ko:K01176 ko00500,ko01100,ko04973,map00500,map01100,map04973 R02108,R02112,R11262 ko00000,ko00001,ko01000 GH13 iLJ478.TM1840 Bacteria 2J6AH@203691,COG0366@1,COG0366@2 NA|NA|NA G PFAM Alpha amylase, catalytic domain MAG.T12.14_02108 1123320.KB889667_gene2923 4.4e-168 597.4 Actinobacteria pheS GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 2GJGG@201174,COG0016@1,COG0016@2 NA|NA|NA J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily MAG.T12.14_02109 269800.Tfu_2060 1e-260 906.4 Streptosporangiales pheT GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0019538,GO:0019752,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 2GMFD@201174,4EGYI@85012,COG0072@1,COG0072@2,COG0073@1,COG0073@2 NA|NA|NA J Ferredoxin-fold anticodon binding domain MAG.T12.14_02110 1122963.AUHB01000006_gene2514 8.9e-35 154.1 Alphaproteobacteria Bacteria 1N4Z9@1224,2UE0R@28211,COG1028@1,COG1028@2 NA|NA|NA IQ KR domain MAG.T12.14_02111 1123024.AUII01000002_gene940 4.7e-14 84.3 Pseudonocardiales Bacteria 2I8IW@201174,4EF3K@85010,COG1846@1,COG1846@2 NA|NA|NA K helix_turn_helix multiple antibiotic resistance protein MAG.T12.14_02112 1032480.MLP_44030 3.7e-171 608.2 Propionibacteriales Bacteria 2H32P@201174,4DX0H@85009,COG0477@1,COG2814@2 NA|NA|NA P Fungal trichothecene efflux pump (TRI12) MAG.T12.14_02113 351607.Acel_1263 1.9e-112 412.5 Frankiales argC GO:0000166,GO:0003674,GO:0005488,GO:0008150,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0048037,GO:0050661,GO:0050662,GO:0070401,GO:0097159,GO:1901265,GO:1901363 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKQK@201174,4ES9C@85013,COG0002@1,COG0002@2 NA|NA|NA E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde MAG.T12.14_02114 1449353.JQMQ01000005_gene936 4.3e-145 521.2 Streptacidiphilus argJ GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35,2.7.2.8 ko:K00620,ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282,R02649 RC00002,RC00004,RC00043,RC00064 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIW0@201174,2NEHP@228398,COG1364@1,COG1364@2 NA|NA|NA E ArgJ family MAG.T12.14_02115 28042.GU90_13915 7.8e-110 403.7 Pseudonocardiales argB GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0030312,GO:0031406,GO:0034618,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS10565,iJN678.argB,iLJ478.TM1784 Bacteria 2GKDS@201174,4DXB3@85010,COG0548@1,COG0548@2 NA|NA|NA E Belongs to the acetylglutamate kinase family. ArgB subfamily MAG.T12.14_02116 644283.Micau_2374 5e-128 464.5 Micromonosporales argD GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0008150,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 2GKE9@201174,4DBFJ@85008,COG4992@1,COG4992@2 NA|NA|NA E acetylornithine aminotransferase MAG.T12.14_02117 1288083.AUKR01000003_gene3698 1.5e-43 182.6 Actinobacteria argR GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 ko:K03402 ko00000,ko03000 Bacteria 2GKA5@201174,COG1438@1,COG1438@2 NA|NA|NA K Regulates arginine biosynthesis genes MAG.T12.14_02118 1155718.KB891898_gene1918 7.5e-177 626.7 Actinobacteria argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0071944,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 iNJ661.Rv1658 Bacteria 2GK96@201174,COG0137@1,COG0137@2 NA|NA|NA E Belongs to the argininosuccinate synthase family. Type MAG.T12.14_02119 1120950.KB892768_gene5196 1.7e-183 649.0 Propionibacteriales argH GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0030312,GO:0040007,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 iJN678.argH Bacteria 2GJ2A@201174,4DPEP@85009,COG0165@1,COG0165@2 NA|NA|NA E argininosuccinate lyase MAG.T12.14_02120 1440053.JOEI01000018_gene518 1.3e-147 529.6 Actinobacteria tyrS GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0030312,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 Bacteria 2GJPR@201174,COG0162@1,COG0162@2 NA|NA|NA J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) MAG.T12.14_02121 266940.Krad_0700 3e-47 194.1 Actinobacteria rplE GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02931 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GJW7@201174,COG0094@1,COG0094@2 NA|NA|NA J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits MAG.T12.14_02122 446471.Xcel_0640 4.5e-25 119.8 Promicromonosporaceae rpsN GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02954 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IQ8R@201174,4F4WT@85017,COG0199@1,COG0199@2 NA|NA|NA J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site MAG.T12.14_02123 1121385.AQXW01000004_gene2023 3.4e-54 217.6 Dermacoccaceae rpsH GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 ko:K02994 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1ZVXC@145357,2IHQZ@201174,COG0096@1,COG0096@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit MAG.T12.14_02124 1133850.SHJG_5812 2.1e-75 288.5 Actinobacteria rplF GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02933 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GK35@201174,COG0097@1,COG0097@2 NA|NA|NA J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center MAG.T12.14_02125 1048339.KB913029_gene2766 1e-39 169.5 Frankiales rplR GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02881 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IKTX@201174,4ESW2@85013,COG0256@1,COG0256@2 NA|NA|NA J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance MAG.T12.14_02126 105420.BBPO01000022_gene5786 1.6e-66 259.2 Streptacidiphilus rpsE GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990145,GO:1990904 ko:K02988 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GJW8@201174,2NG8M@228398,COG0098@1,COG0098@2 NA|NA|NA J Ribosomal protein S5, C-terminal domain MAG.T12.14_02127 1121933.AUHH01000003_gene1376 1.2e-14 85.1 Propionibacteriales rpmD GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02907 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GQV0@201174,4DSCE@85009,COG1841@1,COG1841@2 NA|NA|NA J Ribosomal protein L30 MAG.T12.14_02128 1095767.CAHD01000130_gene1318 1.2e-52 212.6 Cellulomonadaceae rplO GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02876 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2II6M@201174,4F16W@85016,COG0200@1,COG0200@2 NA|NA|NA J Binds to the 23S rRNA MAG.T12.14_02129 1504319.GM45_2550 3.4e-159 568.2 unclassified Actinobacteria (class) secY GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5 Bacteria 2GJ26@201174,3UWEW@52018,COG0201@1,COG0201@2 NA|NA|NA U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently MAG.T12.14_02130 1120941.AUBL01000002_gene2052 1.3e-59 236.1 Actinobacteria adk 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GJ7T@201174,4D4SK@85005,COG0563@1,COG0563@2 NA|NA|NA F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism MAG.T12.14_02131 1120950.KB892746_gene3632 3.7e-79 301.6 Propionibacteriales map GO:0000096,GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006464,GO:0006508,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009066,GO:0009987,GO:0010467,GO:0016020,GO:0016151,GO:0016485,GO:0016787,GO:0019538,GO:0019752,GO:0030145,GO:0035551,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044464,GO:0046872,GO:0046914,GO:0050897,GO:0051604,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901605 3.4.11.18 ko:K01265 ko00000,ko01000,ko01002 Bacteria 2GKKB@201174,4DNQ9@85009,COG0024@1,COG0024@2 NA|NA|NA J Methionine aminopeptidase MAG.T12.14_02132 530564.Psta_3683 8.3e-134 483.8 Planctomycetes Bacteria 2IX7A@203682,COG0464@1,COG0464@2 NA|NA|NA O growth MAG.T12.14_02133 530564.Psta_3683 4.4e-135 488.0 Planctomycetes Bacteria 2IX7A@203682,COG0464@1,COG0464@2 NA|NA|NA O growth MAG.T12.14_02134 269800.Tfu_2622 1.2e-32 145.2 Streptosporangiales infA GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009986,GO:0016020,GO:0030246,GO:0030247,GO:0030312,GO:0040007,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071944,GO:2001065 ko:K02518 ko00000,ko03012 Bacteria 2IQ4B@201174,4EK2Q@85012,COG0361@1,COG0361@2 NA|NA|NA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex MAG.T12.14_02135 1284679.HMPREF1626_05675 1.4e-13 80.9 Actinobacteria rpmJ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02919 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GWMH@201174,4D6P0@85005,COG0257@1,COG0257@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL36 family MAG.T12.14_02136 469371.Tbis_0590 1.1e-52 212.6 Pseudonocardiales rpsM GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02952 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IHPN@201174,4E3FF@85010,COG0099@1,COG0099@2 NA|NA|NA J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits MAG.T12.14_02137 1306174.JODP01000006_gene3594 3.9e-61 240.7 Actinobacteria rpsK GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02948 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IFFC@201174,COG0100@1,COG0100@2 NA|NA|NA J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome MAG.T12.14_02138 1123320.KB889574_gene5545 1.5e-96 359.0 Actinobacteria rpsD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0016020,GO:0019222,GO:0019843,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 ko:K02986 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GIRX@201174,COG0522@1,COG0522@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit MAG.T12.14_02139 471852.Tcur_4290 5.8e-151 540.4 Streptosporangiales rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 Bacteria 2GJJ5@201174,4EGUV@85012,COG0202@1,COG0202@2 NA|NA|NA K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates MAG.T12.14_02140 471853.Bcav_3112 4.2e-53 214.5 Actinobacteria rplQ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 ko:K02879 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IHV2@201174,COG0203@1,COG0203@2 NA|NA|NA J ribosomal protein L17 MAG.T12.14_02141 1095767.CAHD01000130_gene1332 8e-80 303.9 Cellulomonadaceae truA GO:0000049,GO:0001522,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 5.4.99.12 ko:K06173 ko00000,ko01000,ko03016 Bacteria 2GJ6C@201174,4F0W6@85016,COG0101@1,COG0101@2 NA|NA|NA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs MAG.T12.14_02142 1122138.AQUZ01000015_gene6722 6.7e-224 783.5 Propionibacteriales Bacteria 2GMUD@201174,4DNQ6@85009,COG0488@1,COG0488@2 NA|NA|NA S ABC transporter MAG.T12.14_02143 269800.Tfu_0522 6.3e-25 120.2 Streptosporangiales ybaZ GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0005488,GO:0005515,GO:0019899,GO:0097159,GO:1901363 2.1.1.63 ko:K00567,ko:K07443 ko00000,ko01000,ko03400 Bacteria 2GQMD@201174,4EKN0@85012,COG3695@1,COG3695@2 NA|NA|NA L 6-O-methylguanine DNA methyltransferase, DNA binding domain MAG.T12.14_02144 1123321.KB905817_gene5166 1e-61 243.0 Actinobacteria rplM GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0070180,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 ko:K02871 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IFG1@201174,COG0102@1,COG0102@2 NA|NA|NA J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly MAG.T12.14_02145 471853.Bcav_3105 3.5e-56 224.6 Actinobacteria rpsI GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02996 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GNDY@201174,COG0103@1,COG0103@2 NA|NA|NA J Belongs to the universal ribosomal protein uS9 family MAG.T12.14_02146 1120950.KB892784_gene183 3.2e-168 598.2 Propionibacteriales glmM GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006464,GO:0006468,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008966,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019538,GO:0034641,GO:0034654,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046777,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 R02060 RC00408 ko00000,ko00001,ko01000 iAF987.Gmet_1886,iLJ478.TM0184,iSB619.SA_RS11275,iSBO_1134.SBO_3206 Bacteria 2GN87@201174,4DNFP@85009,COG1109@1,COG1109@2 NA|NA|NA G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate MAG.T12.14_02148 44060.JODL01000009_gene1920 1.2e-132 479.6 Actinobacteria nusA GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0040007,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 ko:K02600 ko00000,ko03009,ko03021 Bacteria 2GJDJ@201174,COG0195@1,COG0195@2 NA|NA|NA K Participates in both transcription termination and antitermination MAG.T12.14_02149 1245475.ANAE01000075_gene2816 6.1e-40 170.6 Streptosporangiales rimP GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576 ko:K09748 ko00000,ko03009 Bacteria 2I9BT@201174,4EJF1@85012,COG0779@1,COG0779@2 NA|NA|NA S Required for maturation of 30S ribosomal subunits MAG.T12.14_02150 1449355.JQNR01000005_gene4681 2e-08 65.9 Actinobacteria Bacteria 2EUHF@1,2ISV6@201174,33MZK@2 NA|NA|NA MAG.T12.14_02151 55952.BU52_14505 1.4e-14 86.3 Actinobacteria Bacteria 2EA6A@1,2II4E@201174,334B4@2 NA|NA|NA S Domain of unknown function (DUF4439) MAG.T12.14_02152 1449346.JQMO01000002_gene2006 1.6e-119 436.0 Kitasatospora ko:K06916 ko00000,ko03036 Bacteria 2GNQA@201174,2M1G2@2063,COG1485@1,COG1485@2 NA|NA|NA S AFG1-like ATPase MAG.T12.14_02153 479431.Namu_3543 1.2e-29 136.7 Frankiales ribG 1.1.1.193,3.5.4.26 ko:K00082,ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 Bacteria 2GN2P@201174,4ET37@85013,COG1985@1,COG1985@2 NA|NA|NA H PFAM bifunctional deaminase-reductase domain protein MAG.T12.14_02154 1136417.AZWE01000018_gene977 1.7e-77 296.6 Micromonosporales ligC Bacteria 2I2EA@201174,4DA61@85008,COG1793@1,COG1793@2 NA|NA|NA L DNA ligase MAG.T12.14_02156 1048339.KB913029_gene3893 1.6e-138 499.2 Frankiales Bacteria 2GM0A@201174,4ES0F@85013,COG3285@1,COG3285@2 NA|NA|NA L DNA polymerase LigD MAG.T12.14_02157 640132.Srot_1648 1.7e-57 228.8 Actinobacteria msrB 1.8.4.12 ko:K07305 ko00000,ko01000 Bacteria 2IHV0@201174,COG0229@1,COG0229@2 NA|NA|NA O peptide-methionine (R)-S-oxide reductase MAG.T12.14_02158 585531.HMPREF0063_10544 3e-85 321.6 Propionibacteriales hemH GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 Bacteria 2GK24@201174,4DP69@85009,COG3253@1,COG3253@2 NA|NA|NA S Chlorite dismutase MAG.T12.14_02159 1380346.JNIH01000057_gene20 6.8e-119 434.5 Actinobacteria hemG 1.3.3.15,1.3.3.4 ko:K00231 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03222,R04178 RC00885 ko00000,ko00001,ko00002,ko01000 Bacteria 2GMMA@201174,COG1232@1,COG1232@2 NA|NA|NA H Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX MAG.T12.14_02160 1137269.AZWL01000022_gene3485 1.3e-119 436.4 Actinobacteria hemE GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_0016 Bacteria 2GMY6@201174,COG0407@1,COG0407@2 NA|NA|NA H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III MAG.T12.14_02161 1385519.N801_01520 1.7e-47 196.4 Intrasporangiaceae Bacteria 2GM50@201174,4FGFA@85021,COG0697@1,COG0697@2 NA|NA|NA EG EamA-like transporter family MAG.T12.14_02162 1298863.AUEP01000018_gene3870 2.2e-54 218.8 Propionibacteriales Bacteria 2AIF4@1,2GK8R@201174,318WM@2,4DQE6@85009 NA|NA|NA S Protein of unknown function (DUF3000) MAG.T12.14_02163 1137271.AZUM01000001_gene1482 2.3e-25 122.5 Pseudonocardiales Bacteria 2GIXT@201174,4DXKI@85010,COG2197@1,COG2197@2 NA|NA|NA K response regulator MAG.T12.14_02164 1463858.JOHR01000014_gene5354 3.4e-125 455.3 Actinobacteria rnd 3.1.13.5 ko:K03684 ko00000,ko01000,ko03016 Bacteria 2GKNM@201174,COG0349@1,COG0349@2 NA|NA|NA J 3-5 exonuclease MAG.T12.14_02165 345341.KUTG_00976 1.5e-87 330.5 Pseudonocardiales Bacteria 2GIZF@201174,4DYN9@85010,COG5001@1,COG5001@2 NA|NA|NA T Diguanylate cyclase MAG.T12.14_02166 743718.Isova_1764 2e-229 802.0 Promicromonosporaceae dxs GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008614,GO:0008615,GO:0008654,GO:0008661,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009240,GO:0009987,GO:0016740,GO:0016744,GO:0017144,GO:0018130,GO:0019288,GO:0019438,GO:0019637,GO:0019682,GO:0019752,GO:0019842,GO:0030976,GO:0032787,GO:0034641,GO:0036094,GO:0042180,GO:0042181,GO:0042364,GO:0042723,GO:0042724,GO:0042816,GO:0042819,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046490,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:1901135,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663,GO:1901681 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 iEcSMS35_1347.EcSMS35_0456,iIT341.HP0354,iJN746.PP_0527 Bacteria 2GMFA@201174,4F36H@85017,COG1154@1,COG1154@2 NA|NA|NA H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) MAG.T12.14_02167 1146883.BLASA_3285 5.4e-22 110.5 Actinobacteria Bacteria 2E8DB@1,2IHS0@201174,332RT@2 NA|NA|NA MAG.T12.14_02168 653386.HMPREF0975_01859 1.2e-38 165.6 Actinobacteria acnA GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005506,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008198,GO:0009060,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0030312,GO:0030350,GO:0032787,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046459,GO:0046872,GO:0046914,GO:0047456,GO:0048037,GO:0050896,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GJD5@201174,4D4IX@85005,COG1048@1,COG1048@2 NA|NA|NA C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate MAG.T12.14_02169 1449069.JMLO01000017_gene3295 1.4e-28 133.7 Nocardiaceae VP1530 ko:K07164 ko00000 Bacteria 2GN5K@201174,4FWY1@85025,COG1579@1,COG1579@2,COG5473@1,COG5473@2 NA|NA|NA J Zn-ribbon protein possibly nucleic acid-binding MAG.T12.14_02170 1122138.AQUZ01000081_gene4871 2.6e-44 186.0 Propionibacteriales mutT 3.6.1.55 ko:K03574,ko:K08296 ko00000,ko01000,ko03400 Bacteria 2I2N2@201174,4DWX8@85009,COG1051@1,COG1051@2,COG2062@1,COG2062@2 NA|NA|NA FT Phosphoglycerate mutase family MAG.T12.14_02171 1304865.JAGF01000001_gene2382 1e-114 420.6 Actinobacteria Bacteria 2GJZH@201174,COG5607@1,COG5607@2 NA|NA|NA S CHAD domain containing protein MAG.T12.14_02172 1894.JOER01000041_gene1494 4.3e-284 983.8 Actinobacteria ppk 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 2GJ0B@201174,COG0855@1,COG0855@2 NA|NA|NA P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) MAG.T12.14_02173 35754.JNYJ01000038_gene4955 2.8e-81 308.9 Micromonosporales mshD GO:0000302,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006950,GO:0006979,GO:0008080,GO:0008150,GO:0008152,GO:0009058,GO:0009268,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0010125,GO:0010126,GO:0010447,GO:0016137,GO:0016138,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0033554,GO:0034599,GO:0034614,GO:0035447,GO:0035690,GO:0040007,GO:0042221,GO:0042493,GO:0042542,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044249,GO:0044272,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051186,GO:0051188,GO:0051704,GO:0051716,GO:0070301,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071468,GO:0071704,GO:0097237,GO:0104004,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659,GO:1901700,GO:1901701 2.3.1.189,2.7.4.1 ko:K00937,ko:K15520 ko00190,ko03018,map00190,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 2GM35@201174,4D8MC@85008,COG0454@1,COG0456@2 NA|NA|NA K Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol MAG.T12.14_02174 28444.JODQ01000002_gene4547 2.7e-89 335.1 Streptosporangiales Bacteria 2GJGU@201174,4EI8P@85012,COG0745@1,COG0745@2 NA|NA|NA KT Transcriptional regulatory protein, C terminal MAG.T12.14_02175 471852.Tcur_0600 3.6e-37 161.4 Streptosporangiales thiX 1.8.1.8 ko:K02199,ko:K03671,ko:K03672 ko04621,ko05418,map04621,map05418 ko00000,ko00001,ko01000,ko03110 Bacteria 2IKMI@201174,4EK0E@85012,COG0526@1,COG0526@2 NA|NA|NA CO Thioredoxin MAG.T12.14_02176 436229.JOEH01000023_gene761 2.4e-32 145.2 Streptacidiphilus Bacteria 2AN8T@1,2I81P@201174,2NNJW@228398,327DN@2 NA|NA|NA S Domain of unknown function (DUF4395) MAG.T12.14_02177 561175.KB894093_gene2870 9.2e-18 98.6 Streptosporangiales ko:K14340 ko00000,ko01000,ko01003 Bacteria 2GN7C@201174,4EPB5@85012,COG5305@1,COG5305@2 NA|NA|NA S Dolichyl-phosphate-mannose-protein mannosyltransferase MAG.T12.14_02178 269800.Tfu_2924 1.4e-33 149.1 Streptosporangiales Bacteria 2IHT6@201174,4EJN0@85012,COG2044@1,COG2044@2 NA|NA|NA S DsrE/DsrF-like family MAG.T12.14_02180 1120950.KB892795_gene2292 1.3e-40 172.9 Propionibacteriales GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 2GKGF@201174,4DQW9@85009,COG4044@1,COG4044@2 NA|NA|NA S May play a role in the intracellular transport of hydrophobic ligands MAG.T12.14_02181 390989.JOEG01000027_gene2201 2.7e-31 141.7 Micromonosporales ko:K03711 ko00000,ko03000 Bacteria 2IFHB@201174,4DEKA@85008,COG0735@1,COG0735@2 NA|NA|NA P Belongs to the Fur family MAG.T12.14_02182 1120950.KB892795_gene2294 3.8e-79 302.0 Propionibacteriales 1.5.99.5,2.1.2.10 ko:K00605,ko:K06980,ko:K22086 ko00260,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200 M00532 R00609,R01221,R02300,R04125 RC00022,RC00069,RC00183,RC00190,RC00557,RC02834 ko00000,ko00001,ko00002,ko01000,ko03016 Bacteria 2I4ER@201174,4DX1V@85009,COG0404@1,COG0404@2 NA|NA|NA E Glycine cleavage T-protein C-terminal barrel domain MAG.T12.14_02183 1172188.KB911820_gene2608 1.1e-61 243.4 Intrasporangiaceae Bacteria 2H8JM@201174,4FG88@85021,COG0491@1,COG0491@2 NA|NA|NA S Metallo-beta-lactamase superfamily MAG.T12.14_02184 452652.KSE_43730 9.9e-40 169.9 Kitasatospora dtd GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106026,GO:0106074,GO:0140098,GO:0140101,GO:1901360 ko:K07560 ko00000,ko01000,ko03016 Bacteria 2IKVR@201174,2M30U@2063,COG1490@1,COG1490@2 NA|NA|NA J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality MAG.T12.14_02185 1128421.JAGA01000002_gene21 2.8e-10 73.2 unclassified Bacteria Bacteria 2NRMR@2323,COG0457@1,COG0457@2 NA|NA|NA O heat shock protein binding MAG.T12.14_02186 1122138.AQUZ01000081_gene4842 6e-93 347.4 Propionibacteriales 2.3.1.247 ko:K18013 ko00310,map00310 R10564 RC02728,RC03199 ko00000,ko00001,ko01000 Bacteria 2I9EQ@201174,4DP9Q@85009,COG3246@1,COG3246@2 NA|NA|NA S beta-keto acid cleavage enzyme MAG.T12.14_02187 1155714.KB891993_gene5428 4.3e-79 301.6 Actinobacteria ansA 3.5.1.1 ko:K01424 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 R00485 RC00010,RC02798 ko00000,ko00001,ko01000 Bacteria 2GJA7@201174,COG4448@1,COG4448@2 NA|NA|NA E L-asparaginase II MAG.T12.14_02189 351607.Acel_0067 4.3e-33 147.5 Frankiales clgR_2 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 Bacteria 2IKVI@201174,4ET27@85013,COG1396@1,COG1396@2 NA|NA|NA K transcriptional regulator, XRE family MAG.T12.14_02190 1206733.BAGC01000061_gene3397 1.3e-15 89.0 Nocardiaceae Bacteria 2EHMU@1,2HM2W@201174,33BDI@2,4G3KX@85025 NA|NA|NA S Protein of unknown function (DUF2516) MAG.T12.14_02191 356851.JOAN01000015_gene2702 7.1e-81 307.4 Micromonosporales 2.1.1.104 ko:K00588 ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110 M00039,M00350 R01942,R06578 RC00003,RC00392 ko00000,ko00001,ko00002,ko01000 Bacteria 2GK2F@201174,4D8DF@85008,COG4122@1,COG4122@2 NA|NA|NA S O-methyltransferase activity MAG.T12.14_02192 1121272.KB903249_gene2500 1.2e-63 249.2 Micromonosporales aspS GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 Bacteria 2GJHU@201174,4DB1U@85008,COG0173@1,COG0173@2 NA|NA|NA J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) MAG.T12.14_02193 1268303.RHODMAR_0244 6.7e-20 104.4 Nocardiaceae copC ko:K07156 ko00000,ko02000 9.B.62.2 Bacteria 2GMKG@201174,4FYGB@85025,COG2372@1,COG2372@2 NA|NA|NA S CopC domain MAG.T12.14_02194 1041522.MCOL_V218443 1.6e-110 407.1 Mycobacteriaceae copD ko:K02351,ko:K07245 ko00000,ko02000 9.B.62.1 Bacteria 233IV@1762,2GKIR@201174,COG3336@1,COG3336@2 NA|NA|NA P CytoChrome c oxidase Caa3 assembly factor MAG.T12.14_02195 1033730.CAHG01000016_gene542 1.8e-29 137.1 Propionibacteriales Bacteria 28MY8@1,2GMYY@201174,2ZB54@2,4DNCX@85009 NA|NA|NA MAG.T12.14_02196 365528.KB891218_gene1492 1e-153 550.1 Frankiales rarA ko:K07478 ko00000 Bacteria 2GKDP@201174,4ERXK@85013,COG2256@1,COG2256@2 NA|NA|NA L AAA ATPase, central domain protein MAG.T12.14_02198 1048339.KB913029_gene3957 0.0 1090.5 Frankiales alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 2GIUG@201174,4ERRJ@85013,COG0013@1,COG0013@2 NA|NA|NA J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain MAG.T12.14_02199 28444.JODQ01000017_gene6586 2.9e-41 174.9 Streptosporangiales yqgF GO:0000966,GO:0000967,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0140097,GO:1901360 ko:K07447 ko00000,ko01000 Bacteria 2IQB0@201174,4EJ6B@85012,COG0816@1,COG0816@2 NA|NA|NA L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA MAG.T12.14_02200 110319.CF8_1908 6.5e-74 284.6 Propionibacteriales mltG ko:K07082 ko00000 Bacteria 2GKGQ@201174,4DN3K@85009,COG1559@1,COG1559@2 NA|NA|NA S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation MAG.T12.14_02201 1210045.ALNP01000016_gene1959 6e-64 251.1 Actinobacteria aroE GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv2552c Bacteria 2GPQQ@201174,COG0169@1,COG0169@2 NA|NA|NA E Shikimate dehydrogenase MAG.T12.14_02202 861299.J421_3061 1.1e-08 68.6 Gemmatimonadetes Bacteria 1ZSPN@142182,COG0457@1,COG0457@2 NA|NA|NA S Domain of unknown function (DUF4388) MAG.T12.14_02203 351607.Acel_1322 3.3e-223 781.2 Frankiales pulE ko:K02652 ko00000,ko02035,ko02044 3.A.15.2 Bacteria 2I8C2@201174,4ES0V@85013,COG2804@1,COG2804@2 NA|NA|NA NU General secretory system II, protein E domain protein MAG.T12.14_02204 590998.Celf_2006 1.3e-151 543.1 Actinobacteria pilT ko:K02669 ko00000,ko02035,ko02044 3.A.15.2 Bacteria 2I9GT@201174,COG2805@1,COG2805@2 NA|NA|NA NU twitching motility protein MAG.T12.14_02205 351607.Acel_1320 2.6e-153 548.5 Frankiales pilC ko:K02653 ko00000,ko02035,ko02044 3.A.15.2 Bacteria 2GQW0@201174,4ERP7@85013,COG1459@1,COG1459@2 NA|NA|NA NU Type II secretion system (T2SS), protein F MAG.T12.14_02206 1120950.KB892759_gene6277 1e-66 261.5 Propionibacteriales Bacteria 2I2J0@201174,4DQBJ@85009,COG2385@1,COG2385@2 NA|NA|NA D PFAM Stage II sporulation D domain protein MAG.T12.14_02207 1120942.AUBM01000007_gene585 1.2e-145 523.1 Actinobacteria nplT Bacteria 2GJUT@201174,4D48F@85005,COG0366@1,COG0366@2 NA|NA|NA G Alpha amylase, catalytic domain protein MAG.T12.14_02208 77635.BISU_0868 9.2e-51 206.8 Bacteria Bacteria COG1309@1,COG1309@2 NA|NA|NA K transcriptional regulator MAG.T12.14_02209 44251.PDUR_02765 6.7e-37 161.0 Paenibacillaceae ko:K05772 ko02010,map02010 M00186 ko00000,ko00001,ko00002,ko02000 3.A.1.6.2,3.A.1.6.4 Bacteria 1UI3M@1239,27712@186822,4ISC5@91061,COG2998@1,COG2998@2 NA|NA|NA H Copper amine oxidase N-terminal domain MAG.T12.14_02210 1100721.ALKO01000016_gene1456 1.8e-86 326.2 Comamonadaceae Bacteria 1MWDP@1224,2VHM1@28216,4ABW8@80864,COG3191@1,COG3191@2 NA|NA|NA EQ PFAM peptidase S58 DmpA MAG.T12.14_02211 1380390.JIAT01000010_gene3784 3.5e-27 128.6 Actinobacteria 1.3.1.33 ko:K00218 ko00860,ko01100,ko01110,map00860,map01100,map01110 R03845,R06286 RC01008 ko00000,ko00001,ko01000 Bacteria 2I3A4@201174,COG4221@1,COG4221@2 NA|NA|NA S short chain dehydrogenase MAG.T12.14_02212 1172188.KB911822_gene998 6e-58 231.1 Intrasporangiaceae ko:K06996 ko00000 Bacteria 2GJFC@201174,4FGZF@85021,COG3324@1,COG3324@2 NA|NA|NA S glyoxalase bleomycin resistance protein dioxygenase MAG.T12.14_02213 1323663.AROI01000026_gene1819 9.4e-75 288.5 Proteobacteria Bacteria 1MU2C@1224,COG5001@1,COG5001@2 NA|NA|NA T Diguanylate cyclase MAG.T12.14_02214 1386089.N865_06805 1e-166 593.2 Intrasporangiaceae ndh 1.6.99.3 ko:K03885 ko00190,map00190 ko00000,ko00001,ko01000 Bacteria 2GJFE@201174,4FENQ@85021,COG1252@1,COG1252@2 NA|NA|NA C NADH dehydrogenase MAG.T12.14_02215 1032480.MLP_00540 3.1e-170 605.5 Propionibacteriales hvsT ko:K03321 ko00000,ko02000 2.A.53.3 Bacteria 2GJCB@201174,4DP1B@85009,COG0659@1,COG0659@2,COG4530@1,COG4530@2 NA|NA|NA P Sulfate permease family MAG.T12.14_02216 1128421.JAGA01000001_gene2274 2.3e-106 392.1 unclassified Bacteria scrK 2.7.1.2,2.7.1.4 ko:K00845,ko:K00847 ko00010,ko00051,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00051,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R00760,R00867,R01600,R01786,R03920 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 2NQJS@2323,COG1940@1,COG1940@2 NA|NA|NA GK ROK family MAG.T12.14_02217 591159.ACEZ01000204_gene6388 4.5e-88 331.6 Actinobacteria Bacteria 2GJBJ@201174,COG1609@1,COG1609@2 NA|NA|NA K lacI family MAG.T12.14_02218 1120950.KB892811_gene7249 8.8e-09 66.2 Propionibacteriales Bacteria 2GITW@201174,4DPHM@85009,COG1167@1,COG1167@2 NA|NA|NA K helix_turn_helix gluconate operon transcriptional repressor MAG.T12.14_02219 1278078.G419_22129 2.2e-109 402.1 Nocardiaceae ppk2 2.7.4.1 ko:K22468 ko00190,ko03018,map00190,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 2GKRN@201174,4FVD3@85025,COG2326@1,COG2326@2 NA|NA|NA S polyphosphate kinase MAG.T12.14_02221 479435.Kfla_3277 1.4e-58 233.0 Propionibacteriales sufR Bacteria 2GN8W@201174,4DQCB@85009,COG2345@1,COG2345@2 NA|NA|NA K Transcriptional regulator MAG.T12.14_02222 1137269.AZWL01000008_gene4672 1.1e-92 346.7 Actinobacteria drrA_2 ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GJBF@201174,COG1131@1,COG1131@2 NA|NA|NA V ABC transporter MAG.T12.14_02223 1394178.AWOO02000020_gene7495 2.9e-49 202.2 Streptosporangiales ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GN6S@201174,4EI28@85012,COG0842@1,COG0842@2 NA|NA|NA V ABC-2 family transporter protein MAG.T12.14_02224 1121385.AQXW01000004_gene1221 1.1e-66 260.4 Dermacoccaceae ctaA ko:K02259 ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714 M00154 R07412 RC00769 ko00000,ko00001,ko00002,ko03029 3.D.4.4 Bacteria 1ZVU4@145357,2GJQX@201174,COG1612@1,COG1612@2 NA|NA|NA O Cytochrome oxidase assembly protein MAG.T12.14_02226 512565.AMIS_40330 5.6e-81 307.4 Micromonosporales Bacteria 2GMVN@201174,4D8W6@85008,COG0745@1,COG0745@2 NA|NA|NA T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain MAG.T12.14_02227 219305.MCAG_00019 5.9e-74 285.0 Micromonosporales 2.7.13.3 ko:K02484,ko:K07653 ko02020,map02020 M00460 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 2I3U8@201174,4D9HY@85008,COG5002@1,COG5002@2 NA|NA|NA T His Kinase A (phosphoacceptor) domain MAG.T12.14_02228 710696.Intca_1695 4.7e-88 331.3 Intrasporangiaceae ctaB GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 Bacteria 2GJMY@201174,4FEY1@85021,COG0109@1,COG0109@2 NA|NA|NA O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group MAG.T12.14_02229 452652.KSE_55490 1.3e-253 882.5 Kitasatospora tkt 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ1K@201174,2M2DG@2063,COG0021@1,COG0021@2 NA|NA|NA G Transketolase, thiamine diphosphate binding domain MAG.T12.14_02230 100226.SCO1943 1.1e-42 179.1 Actinobacteria rbpA Bacteria 2CNY9@1,2IKKZ@201174,31GEE@2 NA|NA|NA K Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters MAG.T12.14_02231 1298863.AUEP01000005_gene2451 9.3e-17 92.4 Propionibacteriales secG GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 Bacteria 2GR31@201174,4DS3V@85009,COG1314@1,COG1314@2 NA|NA|NA U Preprotein translocase SecG subunit MAG.T12.14_02232 500153.JOEK01000014_gene5647 9.2e-104 383.3 Actinobacteria tpiA GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 2.7.2.3,5.3.1.1 ko:K00927,ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01015,R01512 RC00002,RC00043,RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GJXZ@201174,COG0149@1,COG0149@2 NA|NA|NA G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) MAG.T12.14_02233 446471.Xcel_1549 2.9e-136 491.9 Promicromonosporaceae pgk GO:0003674,GO:0003824,GO:0004618,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.2.3,5.3.1.1 ko:K00927,ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01015,R01512 RC00002,RC00043,RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GJC6@201174,4F49B@85017,COG0126@1,COG0126@2 NA|NA|NA G Phosphoglycerate kinase MAG.T12.14_02234 1123322.KB904653_gene803 2.2e-139 501.9 Actinobacteria whiA GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0043937,GO:0044464,GO:0050789,GO:0050793,GO:0065007,GO:0071944 ko:K09762 ko00000 Bacteria 2GJZU@201174,COG1481@1,COG1481@2 NA|NA|NA K May be required for sporulation MAG.T12.14_02235 1380346.JNIH01000005_gene3152 6.8e-91 340.9 Actinobacteria ybhK Bacteria 2GJBW@201174,COG0391@1,COG0391@2 NA|NA|NA S Required for morphogenesis under gluconeogenic growth conditions MAG.T12.14_02236 100226.SCO1952 5.2e-95 354.4 Actinobacteria rapZ GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363 ko:K06958 ko00000,ko03019 Bacteria 2GMWB@201174,COG1660@1,COG1660@2 NA|NA|NA S Displays ATPase and GTPase activities MAG.T12.14_02237 105422.BBPM01000004_gene5337 1.4e-186 659.4 Streptacidiphilus uvrC GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016787,GO:0016788,GO:0030312,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1902494,GO:1905347,GO:1905348,GO:1990391 ko:K03703 ko03420,map03420 ko00000,ko00001,ko03400 Bacteria 2GIS4@201174,2NEJF@228398,COG0322@1,COG0322@2 NA|NA|NA L GIY-YIG type nucleases (URI domain) MAG.T12.14_02238 479431.Namu_4513 7.1e-21 106.3 Bacteria ofn32 ko:K07746 ko00000,ko02048 Bacteria COG2002@1,COG2002@2 NA|NA|NA K toxin-antitoxin pair type II binding MAG.T12.14_02239 767817.Desgi_0838 2.4e-21 108.6 Clostridia Bacteria 1VP5Y@1239,25DSY@186801,COG1569@1,COG1569@2 NA|NA|NA S toxin-antitoxin system, toxin component, PIN family MAG.T12.14_02240 861360.AARI_35180 2.9e-115 422.2 Micrococcaceae Bacteria 1WB05@1268,2GJK7@201174,COG3464@1,COG3464@2 NA|NA|NA L 4.5 Transposon and IS MAG.T12.14_02241 1193181.BN10_1280004 1.7e-47 195.7 Intrasporangiaceae Bacteria 2IFJT@201174,4FGZW@85021,COG3832@1,COG3832@2 NA|NA|NA S Polyketide cyclase / dehydrase and lipid transport MAG.T12.14_02242 1386089.N865_20845 4.2e-21 106.7 Bacteria Bacteria 2EM5W@1,33EV5@2 NA|NA|NA MAG.T12.14_02243 710696.Intca_0352 6.5e-50 203.4 Intrasporangiaceae ko:K07341 ko00000,ko02048 Bacteria 2IR34@201174,4FHP3@85021,COG3654@1,COG3654@2 NA|NA|NA S Fic/DOC family MAG.T12.14_02245 1380370.JIBA01000015_gene330 9e-26 122.9 Actinobacteria Bacteria 2IRGU@201174,COG1846@1,COG1846@2 NA|NA|NA K transcriptional MAG.T12.14_02247 710696.Intca_3499 6.1e-163 580.5 Intrasporangiaceae Bacteria 2GS79@201174,4FFP0@85021,COG3547@1,COG3547@2 NA|NA|NA L Transposase MAG.T12.14_02248 1184609.KILIM_074_00180 1.1e-21 108.6 Actinobacteria Bacteria 2FF53@1,2H9GT@201174,34737@2 NA|NA|NA MAG.T12.14_02249 710696.Intca_3496 3.3e-50 204.1 Intrasporangiaceae ko:K07171 ko00000,ko01000,ko02048 Bacteria 2HY4S@201174,4FJRX@85021,COG2337@1,COG2337@2 NA|NA|NA L PemK-like, MazF-like toxin of type II toxin-antitoxin system MAG.T12.14_02251 1184609.KILIM_005_00630 4.1e-142 511.1 Actinobacteria tniA ko:K07497 ko00000 Bacteria 2IPDN@201174,COG2801@1,COG2801@2 NA|NA|NA L Mu transposase, C-terminal MAG.T12.14_02252 1184609.KILIM_005_00620 5.6e-116 424.1 Bacteria clpB ko:K03695 ko04213,map04213 ko00000,ko00001,ko03110 Bacteria COG0542@1,COG0542@2 NA|NA|NA O response to heat MAG.T12.14_02253 266264.Rmet_3008 9.3e-87 327.4 Burkholderiaceae tniQ Bacteria 1K4K9@119060,1PE75@1224,2C5W7@1,2VM9N@28216,2Z8WC@2 NA|NA|NA S TniQ MAG.T12.14_02254 1454004.AW11_02902 1e-84 319.7 Betaproteobacteria tniR Bacteria 1MXXT@1224,2VJ32@28216,COG1961@1,COG1961@2 NA|NA|NA L Resolvase, N terminal domain MAG.T12.14_02257 1449346.JQMO01000003_gene5623 1.1e-59 237.7 Kitasatospora 2.7.13.3 ko:K07778 ko02020,map02020 M00479 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 2GKJJ@201174,2M2QI@2063,COG3463@1,COG3463@2 NA|NA|NA S Predicted membrane protein (DUF2079) MAG.T12.14_02265 1463934.JOCF01000060_gene3408 1.4e-13 84.0 Actinobacteria Bacteria 2EGYK@1,2GRY2@201174,3493T@2 NA|NA|NA MAG.T12.14_02267 234267.Acid_3078 1.5e-188 666.0 Bacteria Bacteria COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase activity MAG.T12.14_02268 1122611.KB903985_gene3663 7.9e-133 480.7 Streptosporangiales 1.13.12.16 ko:K00459 ko00910,map00910 R00025 RC02541,RC02759 ko00000,ko00001,ko01000 Bacteria 2I93H@201174,4EIEF@85012,COG2070@1,COG2070@2 NA|NA|NA S 2-Nitropropane dioxygenase MAG.T12.14_02269 1454010.JEOE01000011_gene2396 1.3e-88 334.3 Actinobacteria Bacteria 2IBWT@201174,COG4425@1,COG4425@2 NA|NA|NA S Alpha/beta-hydrolase family MAG.T12.14_02271 290397.Adeh_2189 1.4e-36 160.2 Myxococcales Bacteria 1RAAG@1224,2WNJI@28221,2Z2RH@29,42RIX@68525,COG2030@1,COG2030@2 NA|NA|NA I MaoC like domain MAG.T12.14_02273 358823.DF19_41840 3.4e-17 95.1 Actinobacteria ssb1 ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 ko00000,ko00001,ko03029,ko03032,ko03400 Bacteria 2IGBM@201174,COG0629@1,COG0629@2 NA|NA|NA L Single-strand binding protein family MAG.T12.14_02274 864051.BurJ1DRAFT_4671 4.1e-103 381.7 unclassified Burkholderiales dapE1 Bacteria 1KKBA@119065,1MW20@1224,2VIT5@28216,COG0624@1,COG0624@2 NA|NA|NA E Peptidase dimerisation domain MAG.T12.14_02275 987059.RBXJA2T_02912 8.2e-148 530.0 unclassified Burkholderiales GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0006022,GO:0006040,GO:0006082,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017076,GO:0019200,GO:0019752,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046835,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564 2.7.1.221 ko:K07102 ko00520,ko01100,map00520,map01100 R08968,R11024 RC00002,RC00078 ko00000,ko00001,ko01000 Bacteria 1KJBW@119065,1MXCH@1224,2VHBC@28216,COG3178@1,COG3178@2 NA|NA|NA S Phosphotransferase MAG.T12.14_02278 754252.PFREUD_17710 9.4e-78 296.6 Actinobacteria Bacteria 2I9IY@201174,COG0739@1,COG0739@2 NA|NA|NA M peptidase MAG.T12.14_02279 593907.Celgi_0077 1.9e-103 382.1 Cellulomonadaceae aspB Bacteria 2GJ7R@201174,4F0IR@85016,COG0436@1,COG0436@2 NA|NA|NA E PFAM aminotransferase class I and II MAG.T12.14_02280 196162.Noca_1363 1.2e-29 136.0 Propionibacteriales Bacteria 2IIQY@201174,4DR4W@85009,COG1917@1,COG1917@2 NA|NA|NA S Cupin 2, conserved barrel domain protein MAG.T12.14_02281 1195236.CTER_0960 1e-13 83.6 Firmicutes ko:K01163 ko00000 Bacteria 1VBBR@1239,COG1670@1,COG1670@2 NA|NA|NA J Acetyltransferase (GNAT) domain MAG.T12.14_02284 1386089.N865_05460 6.2e-56 223.4 Intrasporangiaceae ko:K06996 ko00000 Bacteria 2IRUY@201174,4FGZX@85021,COG3324@1,COG3324@2 NA|NA|NA S PFAM Glyoxalase bleomycin resistance protein dioxygenase MAG.T12.14_02286 134676.ACPL_2692 7e-192 677.2 Micromonosporales Bacteria 28HJF@1,2ICK7@201174,2Z7UK@2,4DAVB@85008 NA|NA|NA MAG.T12.14_02287 479432.Sros_0062 4.6e-70 271.9 Streptosporangiales tetV Bacteria 2GJPT@201174,4EJ0G@85012,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily MAG.T12.14_02288 1121272.KB903290_gene4678 1.1e-96 360.1 Micromonosporales Bacteria 2C1EG@1,2GK4W@201174,2Z7MZ@2,4DHRJ@85008 NA|NA|NA MAG.T12.14_02289 446466.Cfla_1154 1.2e-226 792.7 Cellulomonadaceae malL 3.2.1.10 ko:K01182 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00801,R01718,R01791,R06199 RC00028,RC00059,RC00077,RC00451 ko00000,ko00001,ko01000 GH13 Bacteria 2GKS4@201174,4F0T5@85016,COG0366@1,COG0366@2 NA|NA|NA G SMART alpha amylase catalytic sub domain MAG.T12.14_02290 1210046.B277_10139 5.4e-175 620.5 Intrasporangiaceae aat3 2.6.1.2,2.6.1.66 ko:K00814,ko:K14260 ko00220,ko00250,ko00290,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00220,map00250,map00290,map00710,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00171 R00258,R01215 RC00006,RC00008,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 2GJ7R@201174,4FFAU@85021,COG0436@1,COG0436@2 NA|NA|NA E in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor MAG.T12.14_02291 1449353.JQMQ01000004_gene6292 4.3e-81 308.5 Streptacidiphilus Bacteria 2GIZ3@201174,2NKDE@228398,COG1814@1,COG1814@2 NA|NA|NA S VIT family MAG.T12.14_02293 408672.NBCG_01400 5.9e-71 275.0 Propionibacteriales 3.2.1.26 ko:K01193 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00801,R00802,R02410,R03635,R03921,R06088 RC00028,RC00077 ko00000,ko00001,ko01000 GH32 Bacteria 2GJ9T@201174,4DS6H@85009,COG1621@1,COG1621@2 NA|NA|NA G Glycosyl hydrolases family 32 MAG.T12.14_02295 1146883.BLASA_2088 2.5e-106 392.1 Frankiales sucB 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GMUV@201174,4ERCG@85013,COG0508@1,COG0508@2 NA|NA|NA C TIGRFAM 2-oxoglutarate dehydrogenase, E2 component MAG.T12.14_02296 1169154.KB897783_gene4646 2e-102 379.0 Actinobacteria GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006066,GO:0006629,GO:0006706,GO:0006707,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008395,GO:0009056,GO:0016020,GO:0016042,GO:0016125,GO:0016127,GO:0016491,GO:0016705,GO:0016709,GO:0020037,GO:0030312,GO:0031073,GO:0036199,GO:0044238,GO:0044281,GO:0044282,GO:0044464,GO:0046164,GO:0046906,GO:0048037,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1901615,GO:1901616,GO:1902652 ko:K07071 ko00000 Bacteria 2GJS0@201174,COG1090@1,COG1090@2 NA|NA|NA S epimerase MAG.T12.14_02298 1464048.JNZS01000006_gene4063 2.6e-72 278.5 Micromonosporales lipB GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0033819,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0071944,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.3.1.181 ko:K03801 ko00785,ko01100,map00785,map01100 R07766,R07769 RC00039,RC00992,RC02867 ko00000,ko00001,ko01000 Bacteria 2GJIX@201174,4DADI@85008,COG0321@1,COG0321@2 NA|NA|NA H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate MAG.T12.14_02299 1077974.GOEFS_009_00220 2.4e-135 488.4 Gordoniaceae lipA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 R07767,R07768 RC01978 ko00000,ko00001,ko01000 Bacteria 2GKD4@201174,4GBJ4@85026,COG0320@1,COG0320@2 NA|NA|NA H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives MAG.T12.14_02300 1123319.AUBE01000003_gene975 1.6e-51 209.5 Actinobacteria GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 Bacteria 2AUFS@1,2GIXC@201174,31K3Y@2 NA|NA|NA S Domain of unknown function (DUF4191) MAG.T12.14_02301 479433.Caci_6340 7.8e-93 347.4 Actinobacteria Bacteria 2GIRA@201174,COG4977@1,COG4977@2 NA|NA|NA K Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain MAG.T12.14_02303 1121017.AUFG01000001_gene2901 5.5e-27 127.5 Intrasporangiaceae Bacteria 2IQMG@201174,4FHT2@85021,COG1714@1,COG1714@2 NA|NA|NA S PFAM RDD domain containing protein MAG.T12.14_02304 1449347.JQLN01000007_gene1653 1e-46 194.5 Kitasatospora Bacteria 2GKEJ@201174,2M1IE@2063,COG1432@1,COG1432@2 NA|NA|NA S NYN domain MAG.T12.14_02305 1048339.KB913029_gene4661 3.3e-232 810.8 Frankiales glnA GO:0001968,GO:0003674,GO:0003824,GO:0004356,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009405,GO:0009605,GO:0009607,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016020,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019222,GO:0019752,GO:0019899,GO:0020012,GO:0030162,GO:0030312,GO:0030682,GO:0031323,GO:0031325,GO:0032268,GO:0032270,GO:0035375,GO:0040007,GO:0043207,GO:0043436,GO:0044044,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046394,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0070613,GO:0071704,GO:0071944,GO:0075136,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1903317,GO:1903319 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 Bacteria 2GMN1@201174,4ES5H@85013,COG0174@1,COG0174@2 NA|NA|NA E TIGRFAM glutamine synthetase, type I MAG.T12.14_02306 996637.SGM_1410 5.5e-105 389.8 Actinobacteria Bacteria 2GQIV@201174,COG5635@1,COG5635@2 NA|NA|NA T Nacht domain MAG.T12.14_02307 367299.JOEE01000003_gene2916 5.4e-41 173.3 Intrasporangiaceae higA ko:K21498 ko00000,ko02048 Bacteria 2IR2S@201174,4FHGX@85021,COG3093@1,COG3093@2 NA|NA|NA K Helix-turn-helix XRE-family like proteins MAG.T12.14_02308 710696.Intca_2901 1.5e-38 165.2 Intrasporangiaceae higB ko:K07334 ko00000,ko02048 Bacteria 2HVCI@201174,4FJJ2@85021,COG3549@1,COG3549@2 NA|NA|NA S RelE-like toxin of type II toxin-antitoxin system HigB MAG.T12.14_02309 1120950.KB892801_gene1727 1.2e-35 156.4 Propionibacteriales ko:K09167 ko00000 Bacteria 2IR88@201174,4DRVV@85009,COG3402@1,COG3402@2 NA|NA|NA S Bacterial PH domain MAG.T12.14_02310 1123320.KB889585_gene1795 8e-87 327.8 Actinobacteria ko:K08981 ko00000 Bacteria 2GJCD@201174,COG3428@1,COG3428@2 NA|NA|NA S PFAM membrane-flanked domain MAG.T12.14_02312 1123320.KB889585_gene1805 1.5e-97 362.8 Actinobacteria Bacteria 2I2F6@201174,COG5495@1,COG5495@2 NA|NA|NA S Oxidoreductase MAG.T12.14_02313 263358.VAB18032_02725 1.1e-79 303.5 Micromonosporales panC GO:0000166,GO:0000287,GO:0001505,GO:0003674,GO:0003824,GO:0004592,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0019482,GO:0019752,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033317,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042133,GO:0042364,GO:0042398,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0065007,GO:0065008,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv3602c Bacteria 2GJEQ@201174,4D99B@85008,COG0414@1,COG0414@2 NA|NA|NA H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate MAG.T12.14_02314 1348663.KCH_34820 2.4e-181 642.1 Kitasatospora nadB 1.3.5.4,1.4.3.16,2.4.2.19 ko:K00244,ko:K00278,ko:K00767 ko00020,ko00190,ko00250,ko00620,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00250,map00620,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00115,M00150,M00173 R00357,R00481,R02164,R03348 RC00006,RC00045,RC02566,RC02877 ko00000,ko00001,ko00002,ko01000 Bacteria 2I2IJ@201174,2M0NV@2063,COG0029@1,COG0029@2 NA|NA|NA H Fumarate reductase flavoprotein C-term MAG.T12.14_02315 1463845.JOIG01000008_gene3720 2.7e-99 368.6 Actinobacteria nadC 1.4.3.16,2.4.2.19 ko:K00278,ko:K00767 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481,R03348 RC00006,RC02566,RC02877 ko00000,ko00001,ko00002,ko01000 Bacteria 2I2IP@201174,COG0157@1,COG0157@2 NA|NA|NA H Belongs to the NadC ModD family MAG.T12.14_02316 35754.JNYJ01000036_gene3729 6.3e-97 360.5 Micromonosporales coaX GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1986 Bacteria 2GMRQ@201174,4D9W0@85008,COG1521@1,COG1521@2 NA|NA|NA H Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis MAG.T12.14_02317 1380390.JIAT01000011_gene2320 4.6e-125 454.9 Rubrobacteria Bacteria 2GKEK@201174,4CR6A@84995,COG4320@1,COG4320@2 NA|NA|NA S Uncharacterized protein conserved in bacteria (DUF2252) MAG.T12.14_02318 1380356.JNIK01000002_gene4723 1.6e-08 66.6 Actinobacteria Bacteria 2EPZ4@1,2GYV7@201174,33HJQ@2 NA|NA|NA MAG.T12.14_02319 1386089.N865_13000 5.1e-48 198.0 Actinobacteria ko:K07025 ko00000 Bacteria 2GN5U@201174,COG1011@1,COG1011@2 NA|NA|NA S haloacid dehalogenase MAG.T12.14_02320 1089544.KB912942_gene4783 1.7e-25 122.5 Pseudonocardiales Bacteria 2IQMV@201174,4EBME@85010,COG4978@1,COG4978@2 NA|NA|NA KT Bacterial transcription activator, effector binding domain MAG.T12.14_02321 266940.Krad_0596 4.4e-59 234.2 Actinobacteria argH GO:0003674,GO:0003824,GO:0004042,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016043,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0040007,GO:0042450,GO:0042802,GO:0042803,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,4.3.2.1 ko:K00619,ko:K14681 ko00220,ko00250,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map01100,map01110,map01130,map01210,map01230 M00028,M00029,M00844 R00259,R01086 RC00004,RC00064,RC00445,RC00447 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_0946 Bacteria 2GJBT@201174,COG1246@1,COG1246@2 NA|NA|NA E N-acetylglutamate synthase MAG.T12.14_02322 1206101.AZXC01000015_gene5031 4.3e-297 1027.3 Actinobacteria ppc GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008964,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0072350 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 iJN678.ppc,iSFV_1184.SFV_4025 Bacteria 2GKDB@201174,COG2352@1,COG2352@2 NA|NA|NA C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle MAG.T12.14_02323 479435.Kfla_6437 4.1e-24 117.5 Propionibacteriales lsr Bacteria 2C4MW@1,2IQ6A@201174,32RKK@2,4DRQX@85009 NA|NA|NA S Lsr2 MAG.T12.14_02324 219305.MCAG_04744 6.8e-39 166.8 Micromonosporales xth 3.1.11.2,6.5.1.1 ko:K01142,ko:K01971 ko03410,ko03450,map03410,map03450 R00381 RC00005 ko00000,ko00001,ko01000,ko03400 Bacteria 2GKEW@201174,4D92U@85008,COG0708@1,COG0708@2 NA|NA|NA L exodeoxyribonuclease III MAG.T12.14_02325 1121385.AQXW01000001_gene776 7.5e-57 227.3 Dermacoccaceae yplQ ko:K11068 ko00000,ko02042 Bacteria 1ZW8F@145357,2GJGQ@201174,COG1272@1,COG1272@2 NA|NA|NA S hemolysin III MAG.T12.14_02326 1449355.JQNR01000005_gene3991 7.9e-100 370.2 Actinobacteria uppS 2.5.1.31,2.5.1.68 ko:K00806,ko:K12503 ko00900,ko01110,map00900,map01110 R06447,R08528 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 Bacteria 2GJCP@201174,COG0020@1,COG0020@2 NA|NA|NA I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids MAG.T12.14_02327 1120950.KB892823_gene569 4.6e-196 690.6 Propionibacteriales phoH ko:K07175 ko00000 Bacteria 2GK8U@201174,4DNRD@85009,COG1875@1,COG1875@2 NA|NA|NA T phosphate starvation-inducible protein PhoH MAG.T12.14_02328 1122239.AULS01000021_gene2490 4.4e-18 98.6 Actinobacteria ko:K21471 ko00000,ko01000,ko01002,ko01011 Bacteria 2I5D4@201174,COG3206@1,COG3206@2 NA|NA|NA M NLP P60 protein MAG.T12.14_02329 926550.CLDAP_40500 5.8e-62 244.6 Chloroflexi Bacteria 2G6KN@200795,COG2220@1,COG2220@2 NA|NA|NA S Belongs to the UPF0173 family MAG.T12.14_02330 1121946.AUAX01000020_gene3142 1.8e-165 589.7 Micromonosporales Bacteria 2HH0Q@201174,4DAQP@85008,COG1524@1,COG1524@2 NA|NA|NA S Type I phosphodiesterase / nucleotide pyrophosphatase MAG.T12.14_02331 981369.JQMJ01000004_gene6082 1.5e-255 888.6 Streptacidiphilus fumB GO:0003674,GO:0003824,GO:0004333,GO:0005488,GO:0005515,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016860,GO:0016862,GO:0016999,GO:0017144,GO:0019752,GO:0033554,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0047808,GO:0048037,GO:0050163,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0055114,GO:0071704,GO:0072350 4.2.1.2 ko:K01676,ko:K01677,ko:K01678 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 iEC55989_1330.EC55989_1778,iPC815.YPO3335 Bacteria 2GK6D@201174,2NHJN@228398,COG1838@1,COG1838@2,COG1951@1,COG1951@2 NA|NA|NA C Fumarase C-terminus MAG.T12.14_02332 68260.JOAY01000028_gene4140 2.7e-15 89.0 Actinobacteria Bacteria 2EID2@1,2IG1H@201174,33C4E@2 NA|NA|NA S Protein of unknown function (DUF4245) MAG.T12.14_02333 593907.Celgi_0687 1.9e-11 75.1 Cellulomonadaceae xseB GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494 3.1.11.6 ko:K03602 ko03430,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 2GR0U@201174,4F2SG@85016,COG1722@1,COG1722@2 NA|NA|NA L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides MAG.T12.14_02334 321955.AAGP01000021_gene1877 6.4e-107 394.4 Brevibacteriaceae xseA GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 3.1.11.6 ko:K03601 ko03430,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 2GJAS@201174,4F8CF@85019,COG1570@1,COG1570@2 NA|NA|NA L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides MAG.T12.14_02335 1380354.JIAN01000008_gene3433 3.2e-122 444.9 Cellulomonadaceae ispH 1.17.7.4,2.7.4.25 ko:K00945,ko:K02945,ko:K03527 ko00240,ko00900,ko01100,ko01110,ko01130,ko03010,map00240,map00900,map01100,map01110,map01130,map03010 M00052,M00096,M00178 R00158,R00512,R01665,R05884,R08210 RC00002,RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko03011 iIT341.HP0400,iLJ478.TM1444 Bacteria 2GIZ7@201174,4F107@85016,COG0761@1,COG0761@2 NA|NA|NA IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis MAG.T12.14_02337 561175.KB894095_gene2362 1.5e-68 266.9 Streptosporangiales rmuC ko:K09760 ko00000 Bacteria 2GP4U@201174,4EHTZ@85012,COG1322@1,COG1322@2 NA|NA|NA S RmuC family MAG.T12.14_02338 196162.Noca_1944 3.3e-58 231.9 Actinobacteria Bacteria 2ASZS@1,2IINR@201174,31IFG@2 NA|NA|NA MAG.T12.14_02340 862751.SACTE_4123 3.4e-146 524.6 Actinobacteria bhbA 5.4.99.2 ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 Bacteria 2GM65@201174,COG1884@1,COG1884@2 NA|NA|NA I Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly MAG.T12.14_02341 1157638.KB892158_gene5453 4.1e-123 448.0 Actinobacteria add GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659 3.5.4.4 ko:K01488 ko00230,ko01100,ko05340,map00230,map01100,map05340 R01560,R02556 RC00477 ko00000,ko00001,ko01000 iNJ661.Rv3313c Bacteria 2GJ6I@201174,COG1816@1,COG1816@2 NA|NA|NA F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism MAG.T12.14_02342 1278078.G419_15843 1.3e-43 183.3 Nocardiaceae deoC GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 4.1.2.4 ko:K01619 ko00030,map00030 R01066 RC00436,RC00437 ko00000,ko00001,ko01000 iSB619.SA_RS00835 Bacteria 2GJIR@201174,4FX02@85025,COG0274@1,COG0274@2 NA|NA|NA F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate MAG.T12.14_02343 585531.HMPREF0063_11453 1e-89 336.7 Propionibacteriales punA GO:0003674,GO:0003824,GO:0004731,GO:0006139,GO:0006152,GO:0006161,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009116,GO:0009120,GO:0009164,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0019439,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042453,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046121,GO:0046122,GO:0046124,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658 2.4.2.1 ko:K03783 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244 RC00033,RC00063,RC00122 ko00000,ko00001,ko01000 Bacteria 2GKEI@201174,4DMXP@85009,COG0005@1,COG0005@2 NA|NA|NA F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate MAG.T12.14_02344 471852.Tcur_4181 2.4e-47 194.9 Streptosporangiales ykqA Bacteria 2GJM9@201174,4EIZE@85012,COG3703@1,COG3703@2 NA|NA|NA P AIG2-like family MAG.T12.14_02345 397278.JOJN01000001_gene2858 5.6e-160 570.9 Propionibacteriales lpdA GO:0000166,GO:0003674,GO:0003824,GO:0003955,GO:0005488,GO:0008150,GO:0008152,GO:0009405,GO:0016491,GO:0016651,GO:0016655,GO:0036094,GO:0043167,GO:0043168,GO:0044419,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0051704,GO:0055114,GO:0070401,GO:0097159,GO:1901265,GO:1901363 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GMP7@201174,4DNPF@85009,COG1249@1,COG1249@2 NA|NA|NA C Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain MAG.T12.14_02346 479433.Caci_0809 2.4e-248 864.8 Actinobacteria bccA 6.3.4.14,6.4.1.2,6.4.1.3 ko:K11263 ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00741 R00742,R01859,R04385 RC00040,RC00097,RC00253,RC00367,RC00609 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIZP@201174,COG4770@1,COG4770@2 NA|NA|NA I carboxylase MAG.T12.14_02347 2074.JNYD01000012_gene432 3.6e-48 198.4 Pseudonocardiales maf GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0030312,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0047429,GO:0071944 1.1.1.25,2.1.1.190 ko:K00014,ko:K03215,ko:K06287 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000,ko03009 Bacteria 2GNI0@201174,4E2ME@85010,COG0424@1,COG0424@2 NA|NA|NA D Maf-like protein MAG.T12.14_02348 1298860.AUEM01000003_gene3722 2.2e-17 97.8 Microbacteriaceae 2.4.1.52 ko:K00712 ko00000,ko01000,ko01003 GT4 Bacteria 2GJBP@201174,4FNSK@85023,COG0438@1,COG0438@2 NA|NA|NA M Glycosyl transferases group 1 MAG.T12.14_02350 235985.BBPN01000058_gene7572 1.8e-231 808.5 Streptacidiphilus pccB 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIRU@201174,2NGRN@228398,COG4799@1,COG4799@2 NA|NA|NA I Carboxyl transferase domain MAG.T12.14_02351 1957.JODX01000002_gene4462 1.1e-45 190.7 Actinobacteria birA GO:0000166,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004077,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009305,GO:0009374,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0017053,GO:0017076,GO:0017144,GO:0018130,GO:0018271,GO:0019538,GO:0019752,GO:0019842,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032991,GO:0033218,GO:0033293,GO:0034641,GO:0035639,GO:0036094,GO:0036211,GO:0042364,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043565,GO:0043603,GO:0043604,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1990837 2.7.1.33,6.3.4.15 ko:K01947,ko:K03524 ko00770,ko00780,ko01100,map00770,map00780,map01100 M00120 R01074,R02971,R03018,R04391,R05145 RC00002,RC00017,RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko00002,ko01000,ko03000 Bacteria 2GN8Q@201174,COG0340@1,COG0340@2 NA|NA|NA H biotin lipoate A B protein ligase MAG.T12.14_02352 500153.JOEK01000003_gene1233 4.5e-58 231.9 Actinobacteria cya 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 Bacteria 2GN02@201174,COG2114@1,COG2114@2 NA|NA|NA T PFAM Adenylyl cyclase class-3 4 guanylyl cyclase MAG.T12.14_02353 1048339.KB913029_gene20 6.5e-39 167.2 Frankiales ko:K07015 ko00000 Bacteria 2IFFV@201174,4ET34@85013,COG2246@1,COG2246@2 NA|NA|NA S PFAM GtrA family protein MAG.T12.14_02356 526225.Gobs_1409 2.6e-45 189.1 Actinobacteria apt 2.4.2.7 ko:K00759 ko00230,ko01100,map00230,map01100 R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko04147 Bacteria 2IHB6@201174,COG0503@1,COG0503@2 NA|NA|NA F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis MAG.T12.14_02357 1184609.KILIM_042_00240 8.8e-22 110.5 Actinobacteria ko:K03088 ko00000,ko03021 Bacteria 2IRNG@201174,COG1595@1,COG1595@2 NA|NA|NA K belongs to the sigma-70 factor family, ECF subfamily MAG.T12.14_02358 290340.AAur_1158 9.7e-29 134.4 Actinobacteria ko:K03088 ko00000,ko03021 Bacteria 2IKVM@201174,COG1595@1,COG1595@2 NA|NA|NA K belongs to the sigma-70 factor family, ECF subfamily MAG.T12.14_02359 471853.Bcav_3589 1.4e-38 166.8 Bacteria MA20_05910 ko:K03668,ko:K09914 ko00000 Bacteria COG3187@1,COG3187@2 NA|NA|NA O response to heat MAG.T12.14_02362 35754.JNYJ01000086_gene2338 9.7e-22 109.4 Micromonosporales Bacteria 2EH37@1,2GQTI@201174,33AV6@2,4DFMM@85008 NA|NA|NA MAG.T12.14_02363 35754.JNYJ01000011_gene741 2.1e-22 111.3 Micromonosporales yozG ko:K07727 ko00000,ko03000 Bacteria 2GQZM@201174,4DEY7@85008,COG3655@1,COG3655@2 NA|NA|NA K Cro/C1-type HTH DNA-binding domain MAG.T12.14_02364 1043205.AFYF01000045_gene2925 1.6e-08 66.6 Intrasporangiaceae Bacteria 2ET1V@1,2GZYR@201174,33KK0@2,4FI7B@85021 NA|NA|NA S Protein of unknown function (DUF2975) MAG.T12.14_02365 644283.Micau_3475 1.9e-27 129.4 Micromonosporales ppaX 3.1.3.18,3.6.1.1 ko:K01091,ko:K06019,ko:K16017 ko00190,ko00630,ko01051,ko01100,ko01110,ko01130,map00190,map00630,map01051,map01100,map01110,map01130 R01334,R06587 RC00017,RC00078 ko00000,ko00001,ko01000 Bacteria 2I9FC@201174,4DFT5@85008,COG0546@1,COG0546@2 NA|NA|NA S HAD-superfamily hydrolase, subfamily IA, variant 3 MAG.T12.14_02366 1120933.ATUY01000009_gene1413 3.1e-208 731.5 Actinobacteria malL 3.2.1.10 ko:K01182 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00801,R01718,R01791,R06199 RC00028,RC00059,RC00077,RC00451 ko00000,ko00001,ko01000 GH13 Bacteria 2GKS4@201174,4D32X@85005,COG0366@1,COG0366@2 NA|NA|NA G Alpha amylase, catalytic domain protein MAG.T12.14_02367 1380354.JIAN01000005_gene2339 3.1e-51 209.1 Actinobacteria ko:K02529 ko00000,ko03000 Bacteria 2GQER@201174,COG1609@1,COG1609@2 NA|NA|NA K PFAM regulatory protein LacI MAG.T12.14_02368 710696.Intca_0789 5.4e-21 106.7 Intrasporangiaceae Bacteria 2GS79@201174,4FFP0@85021,COG3547@1,COG3547@2 NA|NA|NA L Transposase MAG.T12.14_02369 1193181.BN10_160001 1.7e-195 688.7 Intrasporangiaceae ko:K07493 ko00000 Bacteria 2GM8F@201174,4FJAV@85021,COG3328@1,COG3328@2 NA|NA|NA L Transposase, Mutator family MAG.T12.14_02370 33876.JNXY01000001_gene6365 5.5e-117 427.6 Micromonosporales ko:K07497 ko00000 Bacteria 2GNRT@201174,4DHN8@85008,COG2801@1,COG2801@2 NA|NA|NA L Integrase core domain MAG.T12.14_02371 930171.Asphe3_37560 6.6e-154 550.8 Actinobacteria Bacteria 2IA0I@201174,COG3666@1,COG3666@2 NA|NA|NA L Protein involved in DNA binding, transposase activity and DNA transposition MAG.T12.14_02372 318424.EU78_00435 5.1e-34 149.8 Mycobacteriaceae Bacteria 23F1P@1762,2GM8F@201174,COG3328@1,COG3328@2 NA|NA|NA L Transposase MAG.T12.14_02373 1380356.JNIK01000018_gene606 2.3e-44 187.6 Frankiales Bacteria 2GKF3@201174,4ETTR@85013,COG0577@1,COG0577@2 NA|NA|NA V FtsX-like permease family MAG.T12.14_02374 1120936.KB907222_gene2285 2.2e-78 298.9 Streptosporangiales lolD ko:K02003 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GM25@201174,4EIIZ@85012,COG1136@1,COG1136@2 NA|NA|NA V ATPases associated with a variety of cellular activities MAG.T12.14_02375 1449976.KALB_8405 1.3e-40 172.9 Pseudonocardiales Bacteria 2GNA1@201174,4DXC5@85010,COG1695@1,COG1695@2 NA|NA|NA K Transcriptional regulator MAG.T12.14_02376 1121019.AUMN01000004_gene1337 1.2e-07 63.5 Micrococcaceae Bacteria 1WAGS@1268,2DRTH@1,2GY6H@201174,33CZB@2 NA|NA|NA MAG.T12.14_02377 1123320.KB889596_gene8626 1.5e-17 96.3 Actinobacteria ko:K03088 ko00000,ko03021 Bacteria 2IKVM@201174,COG1595@1,COG1595@2 NA|NA|NA K belongs to the sigma-70 factor family, ECF subfamily MAG.T12.14_02382 1172188.KB911822_gene923 2.4e-27 127.9 Intrasporangiaceae Bacteria 2ISFT@201174,4FHVU@85021,COG2315@1,COG2315@2 NA|NA|NA S YjbR MAG.T12.14_02384 743718.Isova_2573 9.5e-25 120.9 Promicromonosporaceae Bacteria 2ERYQ@1,2GXQP@201174,33JHV@2,4F4YJ@85017 NA|NA|NA MAG.T12.14_02385 593907.Celgi_0953 7.7e-24 116.7 Cellulomonadaceae ko:K07979 ko00000,ko03000 Bacteria 2IQEW@201174,4F2NR@85016,COG1725@1,COG1725@2 NA|NA|NA K Helix-turn-helix domain MAG.T12.14_02388 1210046.B277_10696 3.6e-41 173.7 Intrasporangiaceae yoeB ko:K19158 ko00000,ko01000,ko02048 Bacteria 2IQAJ@201174,4FHKN@85021,COG4115@1,COG4115@2 NA|NA|NA S YoeB-like toxin of bacterial type II toxin-antitoxin system MAG.T12.14_02389 1184607.AUCHE_20_00230 6.6e-32 142.9 Actinobacteria 2.3.1.15 ko:K08591,ko:K19159 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004,ko02048 Bacteria 2IQ6H@201174,COG2161@1,COG2161@2 NA|NA|NA D Antitoxin component of a toxin-antitoxin (TA) module MAG.T12.14_02391 1116232.AHBF01000113_gene4604 8.7e-245 852.8 Actinobacteria pgm GO:0000271,GO:0003674,GO:0003824,GO:0004614,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0005996,GO:0006006,GO:0006012,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0016868,GO:0019318,GO:0019320,GO:0019388,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0055114,GO:0071704,GO:1901575,GO:1901576 5.4.2.2 ko:K01835 ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00549 R00959,R01057,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 iAPECO1_1312.APECO1_1376,iECED1_1282.ECED1_0670,iECNA114_1301.ECNA114_0627,iECOK1_1307.ECOK1_0699,iECP_1309.ECP_0709,iECS88_1305.ECS88_0725,iJN678.pgm,iLF82_1304.LF82_1632,iNRG857_1313.NRG857_03110,iUMN146_1321.UM146_14115,iYL1228.KPN_00711 Bacteria 2H1PI@201174,COG0033@1,COG0033@2 NA|NA|NA G Phosphoglucomutase MAG.T12.14_02392 1306174.JODP01000029_gene3831 3.3e-30 138.7 Actinobacteria ko:K03088 ko00000,ko03021 Bacteria 2IK5Q@201174,COG1595@1,COG1595@2 NA|NA|NA K belongs to the sigma-70 factor family, ECF subfamily MAG.T12.14_02393 1177594.MIC448_2030012 6.4e-17 95.5 Microbacteriaceae ko:K13582 ko04112,map04112 ko00000,ko00001 Bacteria 2GPMH@201174,4FNHW@85023,COG3206@1,COG3206@2 NA|NA|NA M Domain of unknown function (DUF4349) MAG.T12.14_02394 1101188.KI912155_gene948 1.3e-42 179.1 Micrococcaceae 1.8.1.9 ko:K00384,ko:K03671 ko00450,ko04621,ko05418,map00450,map04621,map05418 R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000,ko03110 Bacteria 1W9G6@1268,2IKP1@201174,COG0526@1,COG0526@2 NA|NA|NA CO Belongs to the thioredoxin family MAG.T12.14_02395 1157637.KB892155_gene7597 2.1e-72 279.3 Actinobacteria speE 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 Bacteria 2GN8I@201174,COG0421@1,COG0421@2 NA|NA|NA E spermidine synthase MAG.T12.14_02396 266940.Krad_3968 1e-43 183.3 Actinobacteria Bacteria 2GRF0@201174,COG1514@1,COG1514@2 NA|NA|NA J 2'-5' RNA ligase MAG.T12.14_02397 1150864.MILUP08_40848 6.8e-123 447.2 Micromonosporales trpS GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 2GJ9A@201174,4DAKB@85008,COG0180@1,COG0180@2 NA|NA|NA J Tryptophanyl-tRNA synthetase MAG.T12.14_02398 1122138.AQUZ01000084_gene8782 3.9e-126 458.4 Propionibacteriales ytfL GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03699 ko00000,ko02042 Bacteria 2GKN5@201174,4DPDV@85009,COG1253@1,COG1253@2 NA|NA|NA S Transporter associated domain MAG.T12.14_02399 367299.JOEE01000007_gene23 8.8e-73 280.4 Intrasporangiaceae exoA 3.1.11.2 ko:K01142 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 2GKIS@201174,4FEP7@85021,COG0708@1,COG0708@2 NA|NA|NA L exodeoxyribonuclease III MAG.T12.14_02400 28444.JODQ01000002_gene4308 2e-201 708.4 Streptosporangiales icd GO:0000287,GO:0003674,GO:0003824,GO:0004448,GO:0004450,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006102,GO:0008150,GO:0008152,GO:0008270,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0016999,GO:0017144,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044464,GO:0045333,GO:0046487,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:0072350 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GM3D@201174,4EFHD@85012,COG0538@1,COG0538@2 NA|NA|NA C Isocitrate/isopropylmalate dehydrogenase MAG.T12.14_02402 1278073.MYSTI_01666 2.6e-64 252.7 Myxococcales sua5 GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 2.7.7.87 ko:K07566 R10463 RC00745 ko00000,ko01000,ko03009,ko03016 Bacteria 1MVPM@1224,2WP34@28221,2YV20@29,42T6S@68525,COG0009@1,COG0009@2 NA|NA|NA J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine MAG.T12.14_02403 1394178.AWOO02000005_gene3609 2.4e-266 924.9 Streptosporangiales secA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030312,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 Bacteria 2GIRT@201174,4EGCZ@85012,COG0653@1,COG0653@2 NA|NA|NA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane MAG.T12.14_02404 512565.AMIS_71630 2.5e-19 101.3 Micromonosporales trxA2 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 ko:K03671,ko:K05838 ko04621,ko05418,map04621,map05418 ko00000,ko00001,ko03110 Bacteria 2GJ7B@201174,4D937@85008,COG3118@1,COG3118@2 NA|NA|NA O Thioredoxin MAG.T12.14_02405 1123320.KB889709_gene8400 0.0 1079.3 Actinobacteria glgB GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901576 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 ko00000,ko00001,ko00002,ko01000,ko04147 CBM48,GH13 Bacteria 2GJ5C@201174,COG0296@1,COG0296@2 NA|NA|NA G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position MAG.T12.14_02406 471852.Tcur_3583 3.8e-210 738.0 Streptosporangiales glgE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.4.99.16 ko:K16147 ko00500,ko01100,map00500,map01100 R09994 ko00000,ko00001,ko01000 GH13 Bacteria 2GJKR@201174,4EG8Q@85012,COG0366@1,COG0366@2 NA|NA|NA G Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB MAG.T12.14_02407 1123320.KB889709_gene8414 8.8e-266 922.9 Actinobacteria glgX 3.2.1.196,3.2.1.68 ko:K01214,ko:K02438 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02111,R09995,R11261 ko00000,ko00001,ko00002,ko01000 CBM48,GH13 Bacteria 2GJ00@201174,COG1523@1,COG1523@2 NA|NA|NA G Belongs to the glycosyl hydrolase 13 family MAG.T12.14_02408 269800.Tfu_0590 5.4e-75 287.7 Streptosporangiales echA17 GO:0003674,GO:0003824,GO:0004300,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJW5@201174,4EH13@85012,COG1024@1,COG1024@2 NA|NA|NA I Enoyl-CoA hydratase/isomerase MAG.T12.14_02409 1171373.PACID_16570 2.2e-49 202.2 Propionibacteriales pgsA GO:0003674,GO:0003824,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 Bacteria 2GM3F@201174,4DQ8M@85009,COG0558@1,COG0558@2 NA|NA|NA I Belongs to the CDP-alcohol phosphatidyltransferase class-I family MAG.T12.14_02410 58123.JOFJ01000007_gene696 1e-281 976.1 Streptosporangiales mpg 1.6.5.5,2.7.7.13,5.4.2.10,5.4.2.2,5.4.2.8 ko:K00344,ko:K00966,ko:K01840,ko:K03431,ko:K15778,ko:K16881 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114,M00361,M00362 R00885,R00959,R01057,R01818,R02060,R08639 RC00002,RC00408 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_3178 Bacteria 2GKTE@201174,4EFSZ@85012,COG1109@1,COG1109@2,COG1208@1,COG1208@2 NA|NA|NA GJM Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III MAG.T12.14_02411 479433.Caci_3123 1.2e-27 130.6 Actinobacteria GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 Bacteria 2GMS5@201174,COG3879@1,COG3879@2 NA|NA|NA S protein conserved in bacteria MAG.T12.14_02412 1306174.JODP01000002_gene5961 1.7e-35 155.2 Actinobacteria sbp Bacteria 2IKJW@201174,COG3856@1,COG3856@2 NA|NA|NA S conserved protein (small basic protein) MAG.T12.14_02413 1385518.N798_07750 1.2e-37 163.7 Intrasporangiaceae GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 Bacteria 2GJ3C@201174,4FEXI@85021,COG3879@1,COG3879@2 NA|NA|NA S Bacterial protein of unknown function (DUF881) MAG.T12.14_02414 222534.KB893671_gene3398 2.2e-37 161.8 Frankiales gcvH ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 iNJ661.Rv1826 Bacteria 2IKN2@201174,4ESYX@85013,COG0509@1,COG0509@2 NA|NA|NA E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein MAG.T12.14_02415 570268.ANBB01000003_gene540 1.8e-36 159.1 Streptosporangiales Bacteria 2GK99@201174,4EJ30@85012,COG1716@1,COG1716@2 NA|NA|NA T Inner membrane component of T3SS, cytoplasmic domain MAG.T12.14_02416 1120950.KB892707_gene5034 8.9e-64 250.4 Propionibacteriales merR1 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 Bacteria 2HBV6@201174,4DQDI@85009,COG0789@1,COG0789@2 NA|NA|NA K helix_turn_helix, mercury resistance MAG.T12.14_02417 1303692.SFUL_1738 6.9e-32 144.1 Actinobacteria GO:0008150,GO:0009605,GO:0009607,GO:0020012,GO:0030682,GO:0042783,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0075136 Bacteria 2AN86@1,2HWWU@201174,31D67@2 NA|NA|NA S membrane MAG.T12.14_02418 469371.Tbis_1278 5.1e-139 500.7 Pseudonocardiales GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0004033,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0008076,GO:0008150,GO:0008152,GO:0009117,GO:0009898,GO:0009987,GO:0010959,GO:0012505,GO:0012506,GO:0015459,GO:0016020,GO:0016021,GO:0016192,GO:0016247,GO:0016491,GO:0016614,GO:0016616,GO:0019362,GO:0019637,GO:0019897,GO:0019898,GO:0030141,GO:0030424,GO:0030659,GO:0030667,GO:0031090,GO:0031224,GO:0031226,GO:0031234,GO:0031410,GO:0031982,GO:0032879,GO:0032880,GO:0032940,GO:0032991,GO:0033267,GO:0034641,GO:0034702,GO:0034703,GO:0034705,GO:0034762,GO:0034765,GO:0035579,GO:0036230,GO:0042119,GO:0042581,GO:0042995,GO:0043005,GO:0043226,GO:0043227,GO:0043229,GO:0043266,GO:0043269,GO:0043299,GO:0043312,GO:0044224,GO:0044237,GO:0044238,GO:0044281,GO:0044304,GO:0044422,GO:0044424,GO:0044425,GO:0044433,GO:0044444,GO:0044446,GO:0044459,GO:0044463,GO:0044464,GO:0045055,GO:0045321,GO:0046483,GO:0046496,GO:0046903,GO:0050789,GO:0050794,GO:0050896,GO:0051049,GO:0051179,GO:0051186,GO:0051234,GO:0055086,GO:0055114,GO:0060341,GO:0065007,GO:0065009,GO:0070820,GO:0070821,GO:0070995,GO:0071704,GO:0071944,GO:0072524,GO:0097458,GO:0097708,GO:0098552,GO:0098562,GO:0098588,GO:0098772,GO:0098796,GO:0098797,GO:0098805,GO:0099106,GO:0099503,GO:0120025,GO:0120038,GO:1901360,GO:1901379,GO:1901564,GO:1902495,GO:1903827,GO:1904062,GO:1990031,GO:1990351,GO:2000008 Bacteria 2GMT5@201174,4DX8D@85010,COG0667@1,COG0667@2 NA|NA|NA C aldo keto reductase MAG.T12.14_02419 981369.JQMJ01000004_gene2066 7.6e-16 89.4 Streptacidiphilus Bacteria 2EFWK@1,2IQXQ@201174,2NK0Q@228398,339NW@2 NA|NA|NA MAG.T12.14_02420 1449355.JQNR01000003_gene515 1.1e-26 127.1 Actinobacteria Bacteria 2E883@1,2I8J4@201174,332M6@2 NA|NA|NA MAG.T12.14_02421 1120950.KB892707_gene4769 3.8e-74 285.4 Propionibacteriales ecfT GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015238,GO:0015711,GO:0015893,GO:0016020,GO:0022857,GO:0032217,GO:0032218,GO:0034220,GO:0035461,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051180,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0090482,GO:0098656 ko:K02008,ko:K16783,ko:K16785 ko02010,map02010 M00245,M00246,M00581,M00582 ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23,3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 Bacteria 2GKHK@201174,4DPHW@85009,COG0619@1,COG0619@2 NA|NA|NA P Cobalt transport protein MAG.T12.14_02422 479435.Kfla_2709 2.6e-188 665.2 Propionibacteriales ko:K16786,ko:K16787 ko02010,map02010 M00582 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 Bacteria 2I2Y2@201174,4DP2H@85009,COG3845@1,COG3845@2 NA|NA|NA S AAA domain, putative AbiEii toxin, Type IV TA system MAG.T12.14_02423 1463864.JOGO01000009_gene499 3.8e-66 258.5 Actinobacteria ko:K02006,ko:K16784,ko:K16786,ko:K16787,ko:K16927 ko02010,map02010 M00245,M00246,M00581,M00582 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.18,3.A.1.22,3.A.1.23,3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 Bacteria 2GMK1@201174,COG1122@1,COG1122@2 NA|NA|NA P ECF transporter, substrate-specific component MAG.T12.14_02424 1078020.KEK_15608 2.5e-99 369.4 Mycobacteriaceae cobU 2.7.1.156,2.7.7.62 ko:K02231 ko00860,ko01100,map00860,map01100 M00122 R05221,R05222,R06558 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 Bacteria 23984@1762,2GM8Q@201174,COG1235@1,COG1235@2,COG2087@1,COG2087@2 NA|NA|NA H cobinamide kinase MAG.T12.14_02425 446462.Amir_1358 8.7e-100 370.5 Pseudonocardiales cobT 2.4.2.21 ko:K00768 ko00860,ko01100,map00860,map01100 M00122 R04148 RC00033,RC00063 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv2207 Bacteria 2GJ16@201174,4DX78@85010,COG2038@1,COG2038@2 NA|NA|NA H Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) MAG.T12.14_02426 469371.Tbis_1275 3.1e-35 155.6 Pseudonocardiales cobS GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008818,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.8.26 ko:K02233 ko00860,ko01100,map00860,map01100 M00122 R05223,R11174 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKM4@201174,4E2M6@85010,COG0368@1,COG0368@2 NA|NA|NA H Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate MAG.T12.14_02427 2074.JNYD01000003_gene3655 1.8e-107 396.0 Pseudonocardiales gcvT GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ47@201174,4DXZ6@85010,COG0404@1,COG0404@2 NA|NA|NA E The glycine cleavage system catalyzes the degradation of glycine MAG.T12.14_02428 266940.Krad_3276 1e-127 463.8 Actinobacteria pepA GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 Bacteria 2GJRB@201174,COG0260@1,COG0260@2 NA|NA|NA E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides MAG.T12.14_02429 65497.JODV01000003_gene4511 8.7e-198 696.4 Pseudonocardiales lpdA 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GIXY@201174,4DZEU@85010,COG1249@1,COG1249@2 NA|NA|NA C TIGRFAM Dihydrolipoamide dehydrogenase MAG.T12.14_02430 1095767.CAHD01000205_gene850 9.5e-18 96.7 Bacteria pilA ko:K02650 ko02020,map02020 ko00000,ko00001,ko02035,ko02044 3.A.15.2 Bacteria COG2165@1,COG2165@2 NA|NA|NA NU general secretion pathway protein MAG.T12.14_02431 1048339.KB913029_gene1850 4.2e-38 166.0 Actinobacteria pilV GO:0003674,GO:0005198,GO:0005575,GO:0005623,GO:0008150,GO:0009289,GO:0009405,GO:0009987,GO:0016043,GO:0030030,GO:0042995,GO:0044419,GO:0044464,GO:0051704,GO:0071840 ko:K02457,ko:K02458,ko:K10926,ko:K10930,ko:K10931 ko03070,ko05110,ko05111,map03070,map05110,map05111 M00331 ko00000,ko00001,ko00002,ko02044 3.A.15 Bacteria 2IHD8@201174,COG2165@1,COG2165@2 NA|NA|NA NU general secretion pathway protein MAG.T12.14_02432 1304865.JAGF01000001_gene3205 7.6e-12 77.8 Actinobacteria Bacteria 2FCR1@1,2H815@201174,344U8@2 NA|NA|NA MAG.T12.14_02433 593907.Celgi_1807 1.2e-91 344.4 Actinobacteria Bacteria 2ID24@201174,COG4726@1,COG4726@2 NA|NA|NA NU pilus assembly protein PilW MAG.T12.14_02434 446466.Cfla_1829 2.1e-71 275.8 Cellulomonadaceae hofD 3.4.23.43 ko:K02654 M00331 ko00000,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15.2 Bacteria 2GJ7K@201174,4F1IU@85016,COG1989@1,COG1989@2 NA|NA|NA NOU Type IV leader peptidase family MAG.T12.14_02435 1306174.JODP01000013_gene7517 1.3e-68 266.9 Actinobacteria pilM ko:K02662 ko00000,ko02035,ko02044 Bacteria 2IBNF@201174,COG4972@1,COG4972@2 NA|NA|NA NU pilus assembly protein PilM MAG.T12.14_02436 593907.Celgi_1801 6.1e-17 94.7 Actinobacteria pilN ko:K02663 ko00000,ko02035,ko02044 Bacteria 2IS0C@201174,COG3166@1,COG3166@2 NA|NA|NA NU PFAM Fimbrial assembly family protein MAG.T12.14_02437 266940.Krad_3017 5.1e-08 65.1 Bacteria mshJ ko:K02664,ko:K02665,ko:K12280 ko00000,ko02035,ko02044 Bacteria COG3167@1,COG3167@2 NA|NA|NA NU carbon utilization MAG.T12.14_02439 1120950.KB892708_gene4302 2.7e-155 555.1 Propionibacteriales aroC GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_0976 Bacteria 2GJJN@201174,4DPU4@85009,COG0082@1,COG0082@2 NA|NA|NA E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system MAG.T12.14_02440 1996.JOFO01000006_gene481 8.2e-43 180.3 Streptosporangiales aroK GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0019438,GO:0019632,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71,4.2.3.4 ko:K00891,ko:K13829 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412,R03083 RC00002,RC00078,RC00847 ko00000,ko00001,ko00002,ko01000 Bacteria 2GRFW@201174,4EJ4W@85012,COG0703@1,COG0703@2 NA|NA|NA E Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate MAG.T12.14_02441 471853.Bcav_2021 1.9e-134 485.7 Actinobacteria aroB GO:0003674,GO:0003824,GO:0003856,GO:0005488,GO:0005507,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.71,4.2.3.4 ko:K01735,ko:K13829 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412,R03083 RC00002,RC00078,RC00847 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIUZ@201174,COG0337@1,COG0337@2 NA|NA|NA E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) MAG.T12.14_02442 479432.Sros_6532 3.2e-50 204.5 Streptosporangiales aroQ GO:0003674,GO:0003824,GO:0003855,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:1901576 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 iIT341.HP1038 Bacteria 2IMBY@201174,4EJ73@85012,COG0757@1,COG0757@2 NA|NA|NA E Catalyzes a trans-dehydration via an enolate intermediate MAG.T12.14_02443 1184607.AUCHE_05_06140 1.5e-87 328.9 Dermatophilaceae efp GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02356 ko00000,ko03012 Bacteria 2GJMS@201174,4F6K1@85018,COG0231@1,COG0231@2 NA|NA|NA J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase MAG.T12.14_02444 196162.Noca_2418 5.1e-40 170.6 Propionibacteriales nusB GO:0008150,GO:0040007 ko:K03625 ko00000,ko03009,ko03021 Bacteria 2IM3D@201174,4DR4N@85009,COG0781@1,COG0781@2 NA|NA|NA K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons MAG.T12.14_02445 1229781.C272_07005 2.2e-57 228.8 Brevibacteriaceae pdtaR GO:0000160,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016020,GO:0023052,GO:0030312,GO:0035556,GO:0040007,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071944 ko:K22010 M00839 ko00000,ko00002,ko02022 Bacteria 2GK7T@201174,4F9CZ@85019,COG3707@1,COG3707@2 NA|NA|NA T ANTAR MAG.T12.14_02448 367299.JOEE01000005_gene3472 4.1e-97 361.3 Intrasporangiaceae pyrK ko:K02823 ko00240,ko01100,map00240,map01100 ko00000,ko00001 Bacteria 2HQ24@201174,4FFS3@85021,COG0543@1,COG0543@2 NA|NA|NA C Dihydroorotate oxidase MAG.T12.14_02449 479433.Caci_2405 2.6e-214 751.5 Actinobacteria carB GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 iAF1260.b0033,iBWG_1329.BWG_0031,iECDH10B_1368.ECDH10B_0034,iECDH1ME8569_1439.ECDH1ME8569_0031,iECUMN_1333.ECUMN_0034,iEcDH1_1363.EcDH1_3566,iJN746.PP_4723,iJO1366.b0033,iJR904.b0033,iPC815.YPO0482,iY75_1357.Y75_RS00170,iYL1228.KPN_00041 Bacteria 2GK5N@201174,COG0458@1,COG0458@2 NA|NA|NA F carbamoyl-phosphate synthetase ammonia chain MAG.T12.14_02450 1048339.KB913029_gene3976 1.3e-243 849.0 Frankiales carB GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 iAF1260.b0033,iBWG_1329.BWG_0031,iECDH10B_1368.ECDH10B_0034,iECDH1ME8569_1439.ECDH1ME8569_0031,iECUMN_1333.ECUMN_0034,iEcDH1_1363.EcDH1_3566,iJN746.PP_4723,iJO1366.b0033,iJR904.b0033,iPC815.YPO0482,iY75_1357.Y75_RS00170,iYL1228.KPN_00041 Bacteria 2GK5N@201174,4ERGS@85013,COG0458@1,COG0458@2 NA|NA|NA F Belongs to the CarB family MAG.T12.14_02451 1996.JOFO01000043_gene6393 7.7e-23 114.8 Actinobacteria Bacteria 2GN14@201174,COG2267@1,COG2267@2 NA|NA|NA I Alpha/beta hydrolase family MAG.T12.14_02452 1155718.KB891896_gene2090 2.2e-157 562.0 Actinobacteria carA GO:0000050,GO:0003674,GO:0003824,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0032991,GO:0034641,GO:0034654,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01955,ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 iAPECO1_1312.APECO1_1950,iUTI89_1310.UTI89_C0036,iYO844.BSU15510,ic_1306.c0040 Bacteria 2GKFA@201174,COG0505@1,COG0505@2 NA|NA|NA F Belongs to the CarA family MAG.T12.14_02453 443255.SCLAV_0714 2.4e-29 135.6 Actinobacteria Bacteria 2GM9I@201174,COG0505@1,COG0505@2 NA|NA|NA EF Belongs to the CarA family MAG.T12.14_02454 1146883.BLASA_2361 8.6e-179 633.3 Frankiales pyrC GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ0T@201174,4ERCY@85013,COG0044@1,COG0044@2 NA|NA|NA F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily MAG.T12.14_02455 1123320.KB889665_gene1431 3.1e-138 498.0 Actinobacteria pyrB GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 ko:K00608,ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 iYO844.BSU15490 Bacteria 2GKNA@201174,COG0540@1,COG0540@2 NA|NA|NA F Belongs to the ATCase OTCase family MAG.T12.14_02456 1123320.KB889665_gene1430 7.1e-63 246.9 Actinobacteria pyrR GO:0003674,GO:0003700,GO:0003824,GO:0004845,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006220,GO:0006221,GO:0006355,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0031323,GO:0031326,GO:0034641,GO:0034654,GO:0043094,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046390,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0055086,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0080090,GO:0090407,GO:0140110,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141 2.4.2.9 ko:K02825 ko00240,ko01100,map00240,map01100 R00966 RC00063 ko00000,ko00001,ko01000,ko03000 iHN637.CLJU_RS05275 Bacteria 2GJNP@201174,COG2065@1,COG2065@2 NA|NA|NA F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant MAG.T12.14_02457 1449353.JQMQ01000005_gene847 2.8e-66 258.1 Streptacidiphilus bldD ko:K07110,ko:K21572 ko00000,ko02000,ko03000 8.A.46.1,8.A.46.3 Bacteria 2GVFR@201174,2NEHZ@228398,COG1395@1,COG1395@2 NA|NA|NA K Helix-turn-helix MAG.T12.14_02458 67315.JOBD01000013_gene7146 2.5e-166 592.0 Actinobacteria pyk GO:0003674,GO:0003824,GO:0004743,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016043,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042802,GO:0042866,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 e_coli_core.b1854,iAF1260.b1854,iB21_1397.B21_01813,iBWG_1329.BWG_1668,iEC042_1314.EC042_2021,iECBD_1354.ECBD_1784,iECB_1328.ECB_01825,iECDH10B_1368.ECDH10B_1995,iECDH1ME8569_1439.ECDH1ME8569_1801,iECD_1391.ECD_01825,iECO103_1326.ECO103_2044,iECO111_1330.ECO111_2362,iECO26_1355.ECO26_2692,iECUMN_1333.ECUMN_2152,iETEC_1333.ETEC_1887,iEcDH1_1363.EcDH1_1786,iEcE24377_1341.EcE24377A_2084,iEcHS_1320.EcHS_A1947,iEcSMS35_1347.EcSMS35_1332,iEcolC_1368.EcolC_1778,iG2583_1286.G2583_2306,iJO1366.b1854,iJR904.b1854,iSBO_1134.SBO_1162,iSSON_1240.SSON_1294,iSbBS512_1146.SbBS512_E2130,iUMNK88_1353.UMNK88_2326,iY75_1357.Y75_RS09740 Bacteria 2GJY8@201174,COG0469@1,COG0469@2 NA|NA|NA G Belongs to the pyruvate kinase family MAG.T12.14_02460 935839.JAGJ01000012_gene3014 5.3e-54 217.6 Promicromonosporaceae ftsH2 ko:K03798,ko:K13525 ko04141,ko05134,map04141,map05134 M00400,M00403,M00742 ko00000,ko00001,ko00002,ko01000,ko01002,ko03019,ko03110,ko04131,ko04147 3.A.16.1 Bacteria 2GJ4Q@201174,4F4A7@85017,COG0465@1,COG0465@2 NA|NA|NA O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins MAG.T12.14_02463 405948.SACE_3492 1.2e-100 373.2 Pseudonocardiales MA20_17565 Bacteria 2GNZT@201174,4DZ7M@85010,COG0265@1,COG0265@2 NA|NA|NA O C-terminal PDZ domain MAG.T12.14_02464 1540221.JQNI01000002_gene2504 2.7e-42 177.9 Deinococcus-Thermus Bacteria 1WKYF@1297,COG1028@1,COG1028@2 NA|NA|NA IQ PFAM short chain dehydrogenase MAG.T12.14_02465 1380347.JNII01000005_gene2849 4.3e-48 198.0 Frankiales ko:K10947 ko00000,ko03000 Bacteria 2IFDN@201174,4ET5U@85013,COG1695@1,COG1695@2 NA|NA|NA K Transcriptional regulator MAG.T12.14_02466 469371.Tbis_0943 7.5e-72 276.9 Pseudonocardiales rdgB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66,5.1.1.3 ko:K01776,ko:K02428 ko00230,ko00471,ko01100,map00230,map00471,map01100 R00260,R00426,R00720,R01855,R02100,R02720,R03531 RC00002,RC00302 ko00000,ko00001,ko01000,ko01011 Bacteria 2GM2B@201174,4E0TE@85010,COG0127@1,COG0127@2 NA|NA|NA F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions MAG.T12.14_02467 266940.Krad_3763 9.8e-95 353.2 Actinobacteria rph GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006401,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043170,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:1901361,GO:1901575 2.7.7.56,3.6.1.66 ko:K00989,ko:K02428 ko00230,map00230 R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000,ko03016 Bacteria 2GJFI@201174,COG0689@1,COG0689@2 NA|NA|NA J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates MAG.T12.14_02468 1394178.AWOO02000078_gene2041 5e-70 271.2 Streptosporangiales yhfI GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267 Bacteria 2GMEX@201174,4EIG9@85012,COG1234@1,COG1234@2 NA|NA|NA S Beta-lactamase superfamily domain MAG.T12.14_02469 1146883.BLASA_1169 9.8e-99 366.7 Frankiales murI GO:0000270,GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008657,GO:0008881,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0010911,GO:0016020,GO:0016853,GO:0016854,GO:0016855,GO:0030203,GO:0030234,GO:0032780,GO:0034645,GO:0036361,GO:0042030,GO:0042546,GO:0042802,GO:0043086,GO:0043170,GO:0043462,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0047661,GO:0050790,GO:0051336,GO:0051346,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0072586,GO:0098772,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:2000371,GO:2000372 3.6.1.66,5.1.1.3 ko:K01776,ko:K02428 ko00230,ko00471,ko01100,map00230,map00471,map01100 R00260,R00426,R00720,R01855,R02100,R02720,R03531 RC00002,RC00302 ko00000,ko00001,ko01000,ko01011 iYO844.BSU28390 Bacteria 2GN4I@201174,4ERE1@85013,COG0796@1,COG0796@2 NA|NA|NA M Provides the (R)-glutamate required for cell wall biosynthesis MAG.T12.14_02470 1134445.AJJM01000020_gene2028 2.6e-30 137.9 Actinobacteria clpS GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0050896,GO:0051087 ko:K06891 ko00000 Bacteria 2IQ3Z@201174,COG2127@1,COG2127@2 NA|NA|NA S Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation MAG.T12.14_02471 471852.Tcur_3874 4e-29 134.8 Streptosporangiales Bacteria 2E4AX@1,2GW4T@201174,32Z6K@2,4EJ1I@85012 NA|NA|NA S Domain of unknown function (DUF2017) MAG.T12.14_02472 1313172.YM304_16100 2.9e-52 213.4 Actinobacteria Bacteria 2HZ7I@201174,COG3858@1,COG3858@2 NA|NA|NA S Glycosyl hydrolases family 18 MAG.T12.14_02473 1463920.JOGB01000039_gene946 6.2e-23 113.6 Actinobacteria prmC 2.1.1.297 ko:K02493 R10806 RC00003,RC03279 ko00000,ko01000,ko03012 Bacteria 2GNC1@201174,COG2890@1,COG2890@2 NA|NA|NA J Belongs to the protein N5-glutamine methyltransferase family MAG.T12.14_02474 223184.AS25_09540 2.1e-26 124.8 Micrococcaceae Bacteria 1W9TC@1268,2CAFG@1,2IQ98@201174,32RRB@2 NA|NA|NA S Protein of unknown function (DUF3039) MAG.T12.14_02475 1306174.JODP01000018_gene4493 2.2e-23 115.2 Actinobacteria wblB ko:K18955 ko00000,ko03000 Bacteria 2CC1Y@1,2IQS5@201174,32S23@2 NA|NA|NA K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA MAG.T12.14_02476 1380356.JNIK01000015_gene2347 4.9e-116 424.5 Frankiales argF GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0033554,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 iAF1260.b0273,iECDH10B_1368.ECDH10B_0261,iECS88_1305.ECS88_4841,iHN637.CLJU_RS12430,iJO1366.b0273,iJR904.b0273,iY75_1357.Y75_RS01410 Bacteria 2GJ6H@201174,4ERRI@85013,COG0078@1,COG0078@2 NA|NA|NA E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline MAG.T12.14_02477 1169161.KB897717_gene2918 2.7e-182 644.8 Actinobacteria pckG GO:0000003,GO:0001655,GO:0001822,GO:0001889,GO:0003006,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004457,GO:0004611,GO:0004613,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006066,GO:0006071,GO:0006082,GO:0006089,GO:0006090,GO:0006091,GO:0006094,GO:0006109,GO:0006111,GO:0006113,GO:0006139,GO:0006163,GO:0006464,GO:0006629,GO:0006631,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007028,GO:0007154,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007296,GO:0007610,GO:0008150,GO:0008152,GO:0008906,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009166,GO:0009167,GO:0009179,GO:0009185,GO:0009199,GO:0009205,GO:0009259,GO:0009267,GO:0009410,GO:0009605,GO:0009607,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009889,GO:0009966,GO:0009967,GO:0009987,GO:0009991,GO:0010033,GO:0010106,GO:0010243,GO:0010646,GO:0010647,GO:0010675,GO:0010906,GO:0014070,GO:0014074,GO:0015036,GO:0015980,GO:0016020,GO:0016042,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016054,GO:0016301,GO:0016310,GO:0016491,GO:0016614,GO:0016651,GO:0016667,GO:0016668,GO:0016740,GO:0016772,GO:0016773,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017001,GO:0017144,GO:0018130,GO:0018991,GO:0019098,GO:0019222,GO:0019249,GO:0019318,GO:0019319,GO:0019320,GO:0019362,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019516,GO:0019538,GO:0019541,GO:0019543,GO:0019563,GO:0019626,GO:0019637,GO:0019659,GO:0019660,GO:0019661,GO:0019666,GO:0019674,GO:0019693,GO:0019725,GO:0019751,GO:0019752,GO:0019953,GO:0022412,GO:0022414,GO:0023051,GO:0023056,GO:0030003,GO:0030145,GO:0030154,GO:0030312,GO:0030703,GO:0030855,GO:0031323,GO:0031667,GO:0031668,GO:0031669,GO:0031960,GO:0031974,GO:0032501,GO:0032502,GO:0032504,GO:0032787,GO:0032868,GO:0032869,GO:0032870,GO:0033554,GO:0033993,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035690,GO:0036211,GO:0042221,GO:0042493,GO:0042592,GO:0042594,GO:0042737,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043255,GO:0043412,GO:0043434,GO:0043436,GO:0043687,GO:0043900,GO:0043903,GO:0043949,GO:0043950,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044267,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045471,GO:0046031,GO:0046034,GO:0046164,GO:0046174,GO:0046364,GO:0046365,GO:0046394,GO:0046395,GO:0046434,GO:0046459,GO:0046483,GO:0046496,GO:0046677,GO:0046683,GO:0046700,GO:0046872,GO:0046914,GO:0046916,GO:0047134,GO:0048468,GO:0048477,GO:0048513,GO:0048518,GO:0048522,GO:0048545,GO:0048562,GO:0048568,GO:0048583,GO:0048584,GO:0048598,GO:0048609,GO:0048646,GO:0048731,GO:0048732,GO:0048856,GO:0048869,GO:0048878,GO:0050789,GO:0050792,GO:0050794,GO:0050801,GO:0050896,GO:0051186,GO:0051384,GO:0051591,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055086,GO:0055114,GO:0060429,GO:0061005,GO:0061008,GO:0062012,GO:0065007,GO:0065008,GO:0070013,GO:0070365,GO:0070887,GO:0071236,GO:0071310,GO:0071361,GO:0071375,GO:0071383,GO:0071384,GO:0071385,GO:0071396,GO:0071407,GO:0071417,GO:0071466,GO:0071495,GO:0071496,GO:0071548,GO:0071549,GO:0071704,GO:0071840,GO:0071944,GO:0072001,GO:0072071,GO:0072329,GO:0072330,GO:0072521,GO:0072524,GO:0075136,GO:0080090,GO:0097159,GO:0097237,GO:0097305,GO:0097306,GO:0097327,GO:0098771,GO:1901135,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901575,GO:1901576,GO:1901615,GO:1901616,GO:1901617,GO:1901652,GO:1901653,GO:1901654,GO:1901655,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902533 4.1.1.32,4.1.1.49 ko:K01596,ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964 M00003,M00170 R00341,R00431,R00726 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2638 Bacteria 2GJH3@201174,COG1274@1,COG1274@2 NA|NA|NA H Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle MAG.T12.14_02478 1121946.AUAX01000030_gene1321 1.2e-10 72.0 Micromonosporales Bacteria 2GQKE@201174,4DGEE@85008,COG3677@1,COG3677@2 NA|NA|NA L Transposase MAG.T12.14_02479 862751.SACTE_5342 2.2e-227 795.0 Actinobacteria sir GO:0000096,GO:0000097,GO:0000103,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016002,GO:0016053,GO:0016491,GO:0016667,GO:0016673,GO:0019344,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050311,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.14.13.83,1.7.7.1,1.8.7.1 ko:K00366,ko:K00392,ko:K02229 ko00860,ko00910,ko00920,ko01100,ko01120,map00860,map00910,map00920,map01100,map01120 M00176,M00531 R00790,R00859,R03600,R05217 RC00065,RC00176,RC01979 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJRN@201174,COG0155@1,COG0155@2 NA|NA|NA C Belongs to the nitrite and sulfite reductase 4Fe-4S domain family MAG.T12.14_02481 717773.Thicy_0930 2.5e-63 249.2 Bacteria Bacteria COG1887@1,COG1887@2 NA|NA|NA M Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC MAG.T12.14_02482 1341646.CBMO010000035_gene4653 3e-139 502.3 Mycobacteriaceae sulP GO:0000103,GO:0000166,GO:0003333,GO:0003674,GO:0005215,GO:0005310,GO:0005326,GO:0005342,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006790,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0008152,GO:0008272,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015103,GO:0015116,GO:0015138,GO:0015141,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015238,GO:0015318,GO:0015556,GO:0015698,GO:0015711,GO:0015740,GO:0015741,GO:0015744,GO:0015800,GO:0015807,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0017076,GO:0019001,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0036094,GO:0042221,GO:0042493,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070778,GO:0071422,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0097159,GO:0098656,GO:0098660,GO:0098661,GO:1901265,GO:1901363,GO:1901682,GO:1902358,GO:1902475,GO:1903825,GO:1905039 ko:K03321 ko00000,ko02000 2.A.53.3 Bacteria 236K7@1762,2GJCB@201174,COG0659@1,COG0659@2 NA|NA|NA P Sulfate transporter MAG.T12.14_02484 1122182.KB903816_gene1626 4.5e-26 123.2 Micromonosporales cspA ko:K03704 ko00000,ko03000 Bacteria 2GQRU@201174,4DEWR@85008,COG1278@1,COG1278@2 NA|NA|NA K Cold shock MAG.T12.14_02485 685727.REQ_34670 4.9e-187 661.0 Nocardiaceae cdr ko:K04085 ko04122,map04122 ko00000,ko00001,ko01000,ko03016 Bacteria 2H7WY@201174,4FX6B@85025,COG0446@1,COG0446@2,COG0607@1,COG0607@2 NA|NA|NA P Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain MAG.T12.14_02486 998088.B565_2809 7.1e-36 158.3 Aeromonadales Bacteria 1NEEG@1224,1RZMD@1236,1Y4XF@135624,COG4938@1,COG4938@2 NA|NA|NA D AAA ATPase domain MAG.T12.14_02488 1254432.SCE1572_32985 3.2e-29 136.7 Proteobacteria Bacteria 1N5ID@1224,COG3591@1,COG3591@2 NA|NA|NA E Belongs to the peptidase S1B family MAG.T12.14_02489 935839.JAGJ01000017_gene209 2.1e-65 256.1 Promicromonosporaceae argE Bacteria 2GM84@201174,4F3W6@85017,COG0624@1,COG0624@2 NA|NA|NA E Peptidase dimerisation domain MAG.T12.14_02490 1304865.JAGF01000001_gene687 5.6e-236 823.5 Cellulomonadaceae hppA 3.6.1.1 ko:K15987 ko00190,map00190 ko00000,ko00001,ko01000 3.A.10.1 Bacteria 2GN8B@201174,4F0E3@85016,COG3808@1,COG3808@2 NA|NA|NA C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force MAG.T12.14_02491 1304865.JAGF01000001_gene688 1.7e-156 558.9 Actinobacteria Bacteria 28IW2@1,2IA78@201174,2Z8UC@2 NA|NA|NA MAG.T12.14_02492 478741.JAFS01000001_gene1899 1.3e-54 219.9 unclassified Verrucomicrobia fabI GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0034641,GO:0042364,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.10,1.3.1.9 ko:K00208 ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212 M00083,M00572 R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 iECUMN_1333.ECUMN_1592 Bacteria 37G8S@326457,46UJB@74201,COG0623@1,COG0623@2 NA|NA|NA I Enoyl-(Acyl carrier protein) reductase MAG.T12.14_02493 350054.Mflv_0939 5.7e-11 73.2 Mycobacteriaceae Bacteria 23B65@1762,2EK1R@1,2GWKM@201174,33DS7@2 NA|NA|NA S Phospholipase_D-nuclease N-terminal MAG.T12.14_02494 760011.Spico_1472 2.3e-112 412.1 Spirochaetes metAA GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0008899,GO:0009001,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016750,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.46 ko:K00651 ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230 M00017 R01777 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS11970,iLJ478.TM0881 Bacteria 2J60Z@203691,COG1897@1,COG1897@2 NA|NA|NA E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine MAG.T12.14_02495 1137268.AZXF01000026_gene2413 1.7e-26 126.3 Streptosporangiales ko:K06950 ko00000 Bacteria 2IAVS@201174,4EJTM@85012,COG1418@1,COG1418@2 NA|NA|NA S PFAM metal-dependent phosphohydrolase, HD sub domain MAG.T12.14_02496 469371.Tbis_3425 4e-47 194.1 Pseudonocardiales panD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0016485,GO:0016540,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0051604,GO:0071704,GO:1901564 4.1.1.11 ko:K01579 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R00489 RC00299 ko00000,ko00001,ko00002,ko01000 iECP_1309.ECP_0139,iYL1228.KPN_00139 Bacteria 2IHTC@201174,4E2JG@85010,COG0853@1,COG0853@2 NA|NA|NA H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine MAG.T12.14_02497 685727.REQ_07710 1e-29 137.1 Nocardiaceae Bacteria 2I2JW@201174,4G9F0@85025,COG0500@1,COG2226@2 NA|NA|NA Q Thiopurine S-methyltransferase (TPMT) MAG.T12.14_02498 1380393.JHVP01000007_gene4343 1.6e-86 326.2 Actinobacteria ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GN8P@201174,COG1131@1,COG1131@2 NA|NA|NA V ABC transporter MAG.T12.14_02499 1211815.CBYP010000005_gene232 5.7e-16 92.0 Actinobacteria Bacteria 2GVAC@201174,COG1277@1,COG1277@2 NA|NA|NA S ABC-type transport system involved in multi-copper enzyme maturation permease component MAG.T12.14_02500 1032480.MLP_42530 2.6e-34 152.5 Actinobacteria Bacteria 2I6ZG@201174,COG0639@1,COG0639@2 NA|NA|NA T Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP MAG.T12.14_02502 1120949.KB903335_gene9688 2.5e-32 145.2 Actinobacteria Bacteria 2H6QZ@201174,COG4803@1,COG4803@2 NA|NA|NA S membrane protein of uknown function UCP014873 MAG.T12.14_02503 1255043.TVNIR_2461 7.1e-14 83.6 Chromatiales ko:K11312 ko00000 Bacteria 1QUHG@1224,1T1Z6@1236,1WZ1B@135613,COG0662@1,COG0662@2 NA|NA|NA G PFAM Cupin 2, conserved barrel MAG.T12.14_02504 1499967.BAYZ01000019_gene6314 4.2e-24 117.9 unclassified Bacteria sixA 3.6.1.55 ko:K03574,ko:K08296 ko00000,ko01000,ko03400 Bacteria 2NRKX@2323,COG2062@1,COG2062@2 NA|NA|NA T Histidine phosphatase superfamily (branch 1) MAG.T12.14_02505 1122933.JNIY01000003_gene727 1.2e-63 250.8 Cellulomonadaceae ko:K03281 ko00000 2.A.49 Bacteria 2GJHP@201174,4F2KU@85016,COG0038@1,COG0038@2 NA|NA|NA P Voltage gated chloride channel MAG.T12.14_02508 1120950.KB892769_gene5401 1.3e-142 513.1 Propionibacteriales amt GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03320 ko00000,ko02000 1.A.11 iNJ661.Rv2920c Bacteria 2GIZK@201174,4DNW9@85009,COG0004@1,COG0004@2 NA|NA|NA P Ammonium Transporter Family MAG.T12.14_02509 1961.JOAK01000011_gene5882 1.4e-37 162.2 Actinobacteria glnB ko:K04751 ko02020,map02020 ko00000,ko00001 Bacteria 2IKN1@201174,COG0347@1,COG0347@2 NA|NA|NA K Belongs to the P(II) protein family MAG.T12.14_02510 1001240.GY21_16135 1.2e-52 214.2 Microbacteriaceae ko:K02027,ko:K15770 ko02010,map02010 M00207,M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.2 Bacteria 2HSEH@201174,4FMZA@85023,COG2182@1,COG2182@2 NA|NA|NA G Bacterial extracellular solute-binding protein MAG.T12.14_02511 479431.Namu_4686 1.1e-125 456.8 Bacteria ko:K02027,ko:K15770 ko02010,map02010 M00207,M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.2 Bacteria COG2182@1,COG2182@2 NA|NA|NA G maltose binding MAG.T12.14_02512 479431.Namu_4685 8.2e-208 729.9 Actinobacteria malF GO:0003674,GO:0003824,GO:0005215,GO:0005363,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006950,GO:0006974,GO:0008150,GO:0008643,GO:0009987,GO:0015144,GO:0015154,GO:0015157,GO:0015399,GO:0015405,GO:0015422,GO:0015423,GO:0015766,GO:0015768,GO:0015772,GO:0015774,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033037,GO:0033554,GO:0034219,GO:0042623,GO:0042626,GO:0042956,GO:0043190,GO:0043211,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990060,GO:1990351 ko:K02025,ko:K10109,ko:K10118,ko:K10233,ko:K15771 ko02010,map02010 M00194,M00196,M00201,M00207,M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.1,3.A.1.1.16,3.A.1.1.2,3.A.1.1.22,3.A.1.1.28,3.A.1.1.32,3.A.1.1.8 iZ_1308.Z5631 Bacteria 2GJGB@201174,COG1175@1,COG1175@2 NA|NA|NA G PFAM binding-protein-dependent transport systems inner membrane component MAG.T12.14_02513 479431.Namu_4684 5.3e-122 444.1 Actinobacteria malG GO:0003674,GO:0003824,GO:0005215,GO:0005363,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015154,GO:0015157,GO:0015399,GO:0015405,GO:0015422,GO:0015423,GO:0015766,GO:0015768,GO:0015772,GO:0015774,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033037,GO:0034219,GO:0042623,GO:0042626,GO:0042956,GO:0043190,GO:0043211,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990060,GO:1990351 ko:K10110,ko:K15772 ko02010,map02010 M00194,M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1.1,3.A.1.1.16,3.A.1.1.2,3.A.1.1.22 iLJ478.TM1202,iSSON_1240.SSON_4210,iYL1228.KPN_04421 Bacteria 2I2EZ@201174,COG3833@1,COG3833@2 NA|NA|NA P PFAM binding-protein-dependent transport systems inner membrane component MAG.T12.14_02514 1095767.CAHD01000191_gene271 1.2e-168 600.1 Cellulomonadaceae malZ GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0004558,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009311,GO:0009313,GO:0009987,GO:0015926,GO:0016052,GO:0016787,GO:0016798,GO:0030978,GO:0030980,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044464,GO:0051691,GO:0051692,GO:0071704,GO:0090599,GO:1901575 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 GH31 iECH74115_1262.ECH74115_0480,iEcSMS35_1347.EcSMS35_0434,iSFV_1184.SFV_0368,iYL1228.KPN_00344 Bacteria 2GJUT@201174,4F26G@85016,COG0366@1,COG0366@2 NA|NA|NA G Alpha-amylase domain MAG.T12.14_02515 479431.Namu_4683 1.1e-172 612.8 Frankiales ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 ko00000,ko00001,ko00002,ko02000 3.A.1.1 Bacteria 2GJCM@201174,4ES4E@85013,COG3842@1,COG3842@2 NA|NA|NA P Belongs to the ABC transporter superfamily MAG.T12.14_02516 479431.Namu_4682 2.8e-154 552.4 Actinobacteria malZ GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0004558,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009311,GO:0009313,GO:0009987,GO:0015926,GO:0016052,GO:0016787,GO:0016798,GO:0030978,GO:0030980,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044464,GO:0051691,GO:0051692,GO:0071704,GO:0090599,GO:1901575 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 GH31 iECH74115_1262.ECH74115_0480,iEcSMS35_1347.EcSMS35_0434,iSFV_1184.SFV_0368,iYL1228.KPN_00344 Bacteria 2GJUT@201174,COG0366@1,COG0366@2 NA|NA|NA G alpha amylase, catalytic MAG.T12.14_02518 1463853.JOHW01000024_gene4633 6.6e-33 147.1 Actinobacteria ptpA 3.1.3.48 ko:K01104 ko00000,ko01000 Bacteria 2IM0Q@201174,COG0394@1,COG0394@2 NA|NA|NA T Belongs to the low molecular weight phosphotyrosine protein phosphatase family MAG.T12.14_02519 745411.B3C1_05887 2e-23 117.1 Gammaproteobacteria ispD GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0050518,GO:0070567 2.7.7.60,4.6.1.12 ko:K00991,ko:K12506 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633,R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 Bacteria 1QVUF@1224,1T2J7@1236,COG1211@1,COG1211@2,COG5295@1,COG5295@2 NA|NA|NA UW this gene contains a nucleotide ambiguity which may be the result of a sequencing error MAG.T12.14_02520 1122611.KB903955_gene5558 1.8e-43 182.2 Streptosporangiales rplI GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02939 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IKX7@201174,4EIIV@85012,COG0359@1,COG0359@2 NA|NA|NA J binds to the 23S rRNA MAG.T12.14_02521 479431.Namu_5367 1.5e-28 131.7 Frankiales rpsR GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02963,ko:K03111,ko:K15125 ko03010,ko03030,ko03430,ko03440,ko05133,map03010,map03030,map03430,map03440,map05133 M00178 br01610,ko00000,ko00001,ko00002,ko00536,ko03011,ko03029,ko03032,ko03400 Bacteria 2IQ92@201174,4ESZ0@85013,COG0238@1,COG0238@2 NA|NA|NA J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit MAG.T12.14_02522 471853.Bcav_4180 9.6e-49 199.9 Actinobacteria ssb GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0042221,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071944,GO:0097159,GO:1901363 ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 ko00000,ko00001,ko03029,ko03032,ko03400 Bacteria 2GMM3@201174,COG0629@1,COG0629@2 NA|NA|NA L single-stranded DNA-binding protein MAG.T12.14_02523 1121927.GOHSU_53_00040 2e-35 154.8 Gordoniaceae rpsF GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0019843,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071944,GO:0097159,GO:1901363,GO:1990904 ko:K02990 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011,ko03029 Bacteria 2IQHD@201174,4GEI3@85026,COG0360@1,COG0360@2 NA|NA|NA J Binds together with S18 to 16S ribosomal RNA MAG.T12.14_02524 1348663.KCH_39330 2.4e-127 462.2 Kitasatospora femA Bacteria 2GJUD@201174,2M0RF@2063,COG2348@1,COG2348@2 NA|NA|NA V FemAB family MAG.T12.14_02525 397278.JOJN01000003_gene1778 1.3e-53 217.2 Propionibacteriales Bacteria 2GJJX@201174,4DNS3@85009,COG0787@1,COG0787@2 NA|NA|NA M Alanine racemase, N-terminal domain MAG.T12.14_02526 1449347.JQLN01000005_gene4485 1.9e-113 416.4 Kitasatospora Bacteria 2GJYA@201174,2M0JK@2063,COG5650@1,COG5650@2 NA|NA|NA S Pfam:DUF2029 MAG.T12.14_02527 1504319.GM45_1640 1.7e-155 556.6 unclassified Actinobacteria (class) mrcB 2.4.1.129,3.4.16.4 ko:K05365,ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 GT51 Bacteria 2GK21@201174,3UX6W@52018,COG0744@1,COG0744@2 NA|NA|NA M Transglycosylase MAG.T12.14_02528 1048339.KB913029_gene1638 9.3e-30 136.3 Actinobacteria Bacteria 2CQNK@1,2I83S@201174,323RQ@2 NA|NA|NA S Family of unknown function (DUF5318) MAG.T12.14_02529 266940.Krad_0158 6.3e-88 330.9 Actinobacteria fpg 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 2GKAM@201174,COG0266@1,COG0266@2 NA|NA|NA L Belongs to the FPG family MAG.T12.14_02530 1033730.CAHG01000006_gene1155 4.9e-18 96.7 Propionibacteriales ko:K07213 ko04978,map04978 ko00000,ko00001 Bacteria 2GQK5@201174,4DSND@85009,COG2608@1,COG2608@2 NA|NA|NA P Heavy-metal-associated domain MAG.T12.14_02532 153948.NAL212_0227 1.1e-30 139.8 Nitrosomonadales Bacteria 1PE85@1224,2W92M@28216,373FB@32003,COG0500@1,COG2226@2 NA|NA|NA Q Mycolic acid cyclopropane synthetase MAG.T12.14_02533 1211815.CBYP010000062_gene3157 0.0 1112.8 Frankiales 3.6.3.4 ko:K01533 R00086 RC00002 ko00000,ko01000 3.A.3.5 Bacteria 2GIRF@201174,4ERFZ@85013,COG2217@1,COG2217@2 NA|NA|NA P E1-E2 ATPase MAG.T12.14_02534 1122998.AUHZ01000010_gene1513 1.2e-10 72.4 Propionibacteriales csoR GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010038,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0042221,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0046688,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 ko:K21600 ko00000,ko03000 Bacteria 2IQAC@201174,4DRND@85009,COG1937@1,COG1937@2 NA|NA|NA S Metal-sensitive transcriptional repressor MAG.T12.14_02536 196162.Noca_3785 6.6e-55 220.7 Propionibacteriales 1.11.1.15 ko:K03386,ko:K03564,ko:K16922 ko04214,map04214 ko00000,ko00001,ko01000,ko01002,ko04147 Bacteria 2IGFI@201174,4DRG7@85009,COG1225@1,COG1225@2 NA|NA|NA O Redoxin MAG.T12.14_02537 1122609.AUGT01000027_gene2723 9.8e-114 416.8 Propionibacteriales Bacteria 2GMXW@201174,4DTAU@85009,COG0785@1,COG0785@2 NA|NA|NA O Cytochrome C biogenesis protein transmembrane region MAG.T12.14_02538 446466.Cfla_0354 3.4e-17 94.4 Bacteria Bacteria COG0695@1,COG0695@2 NA|NA|NA O Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins MAG.T12.14_02539 1035308.AQYY01000001_gene2021 9.8e-75 287.3 Peptococcaceae Bacteria 1TQ1H@1239,247VG@186801,264FP@186807,COG5002@1,COG5002@2 NA|NA|NA T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MAG.T12.14_02540 1240349.ANGC01000011_gene329 4.8e-78 297.7 Nocardiaceae Bacteria 2GK5S@201174,4G8SS@85025,COG0745@1,COG0745@2 NA|NA|NA K Transcriptional regulatory protein, C terminal MAG.T12.14_02542 223184.AS25_05575 2.5e-142 512.3 Micrococcaceae Bacteria 1W8P3@1268,2GMJ4@201174,COG2132@1,COG2132@2 NA|NA|NA Q Multicopper oxidase MAG.T12.14_02543 313589.JNB_01175 1.4e-33 149.8 Intrasporangiaceae Bacteria 2IKUE@201174,4FGXY@85021,COG3544@1,COG3544@2 NA|NA|NA S Domain of unknown function (DUF4142) MAG.T12.14_02544 1122138.AQUZ01000019_gene8156 3.5e-38 165.6 Propionibacteriales Bacteria 2GN53@201174,4DRB6@85009,COG4447@1,COG4447@2 NA|NA|NA S cellulose binding MAG.T12.14_02545 1304865.JAGF01000001_gene3502 7.4e-68 263.8 Cellulomonadaceae Bacteria 2HD07@201174,4F18I@85016,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family MAG.T12.14_02546 1304865.JAGF01000001_gene3501 1e-128 466.5 Cellulomonadaceae ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GKEH@201174,4F0VG@85016,COG1131@1,COG1131@2 NA|NA|NA V PFAM ABC transporter related MAG.T12.14_02547 1304865.JAGF01000001_gene3500 1.8e-197 695.7 Actinobacteria ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GMSI@201174,COG3559@1,COG3559@2 NA|NA|NA M Exporter of polyketide MAG.T12.14_02548 68194.JNXR01000009_gene5140 2.5e-13 82.8 Actinobacteria Bacteria 2DDE4@1,2I38G@201174,2ZHP5@2 NA|NA|NA MAG.T12.14_02549 446469.Sked_30030 0.0 1082.8 Actinobacteria Bacteria 2GJJC@201174,COG0474@1,COG0474@2 NA|NA|NA P ATPase P-type (Transporting), HAD superfamily, subfamily IC MAG.T12.14_02550 397278.JOJN01000009_gene3672 3.2e-43 181.0 Propionibacteriales Bacteria 2IKPX@201174,4DRBT@85009,COG4898@1,COG4898@2 NA|NA|NA S Uncharacterized protein conserved in bacteria (DUF2200) MAG.T12.14_02552 1136417.AZWE01000012_gene2545 1.7e-08 67.8 Micromonosporales pspC ko:K03973 ko00000,ko02048,ko03000 Bacteria 2GIVS@201174,4DAQE@85008,COG1983@1,COG1983@2 NA|NA|NA KT PspC domain MAG.T12.14_02553 469383.Cwoe_1650 7.6e-59 234.6 Rubrobacteria tcsS3 Bacteria 2GJ4J@201174,4CRNY@84995,COG1983@1,COG1983@2,COG4585@1,COG4585@2 NA|NA|NA T Histidine kinase-like ATPases MAG.T12.14_02554 479432.Sros_1229 5.6e-65 254.2 Streptosporangiales degU ko:K07684 ko02020,map02020 M00471 ko00000,ko00001,ko00002,ko02022 Bacteria 2GIVA@201174,4EHIU@85012,COG2197@1,COG2197@2 NA|NA|NA T helix_turn_helix, Lux Regulon MAG.T12.14_02555 1121272.KB903254_gene6728 1.9e-76 293.1 Micromonosporales fbpC 3.6.3.30 ko:K02010 ko02010,map02010 M00190 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10 Bacteria 2GJCM@201174,4DCIX@85008,COG3842@1,COG3842@2 NA|NA|NA P TOBE domain MAG.T12.14_02556 1121020.JIAG01000013_gene1260 6.7e-36 157.1 Micrococcaceae Bacteria 1W7ZN@1268,2I2F0@201174,COG0515@1,COG0515@2 NA|NA|NA KLT Domain of unknown function (DUF4032) MAG.T12.14_02557 1123073.KB899241_gene2314 1.4e-28 133.7 Xanthomonadales 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 GH31 Bacteria 1RAB4@1224,1S2JK@1236,1X7DU@135614,COG0366@1,COG0366@2,COG2819@1,COG2819@2 NA|NA|NA G Putative esterase MAG.T12.14_02558 66377.JOBH01000005_gene2852 5.1e-96 357.8 Actinobacteria rlmB GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.185 ko:K03218 ko00000,ko01000,ko03009 Bacteria 2GJMR@201174,COG0566@1,COG0566@2 NA|NA|NA J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family MAG.T12.14_02559 446468.Ndas_4314 2.8e-159 568.5 Streptosporangiales cysS GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16,6.3.1.13 ko:K01883,ko:K15526 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 2GJF2@201174,4EFX4@85012,COG0215@1,COG0215@2 NA|NA|NA J DALR_2 MAG.T12.14_02560 390989.JOEG01000009_gene1007 6.2e-56 223.8 Micromonosporales ispF GO:0003674,GO:0003824,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008685,GO:0009058,GO:0009987,GO:0016114,GO:0016829,GO:0016849,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0051483,GO:0071704,GO:1901576 2.1.1.228,2.7.7.60,4.6.1.12 ko:K00554,ko:K01770,ko:K12506 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R00597,R05633,R05637 RC00002,RC00003,RC00334,RC01440 ko00000,ko00001,ko00002,ko01000,ko03016 iNJ661.Rv3581c Bacteria 2II8H@201174,4DDC4@85008,COG0245@1,COG0245@2 NA|NA|NA I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) MAG.T12.14_02561 862751.SACTE_3674 9.5e-47 193.7 Actinobacteria ispD GO:0000166,GO:0000287,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016114,GO:0016740,GO:0016772,GO:0016779,GO:0019103,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044464,GO:0046490,GO:0046872,GO:0046914,GO:0050518,GO:0051483,GO:0051484,GO:0070567,GO:0071704,GO:0071944,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.405,2.7.7.40,2.7.7.60,4.6.1.12 ko:K00991,ko:K12506,ko:K21681 ko00040,ko00900,ko01100,ko01110,ko01130,map00040,map00900,map01100,map01110,map01130 M00096 R01525,R02921,R05633,R05637 RC00002,RC00089,RC01440 ko00000,ko00001,ko00002,ko01000 Bacteria 2GNHP@201174,COG1211@1,COG1211@2 NA|NA|NA I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) MAG.T12.14_02562 351607.Acel_0079 1.2e-69 270.4 Bacteria yacL GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 Bacteria COG4956@1,COG4956@2 NA|NA|NA S nuclease activity MAG.T12.14_02563 1206101.AZXC01000007_gene2361 5.8e-72 276.9 Actinobacteria carD GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0040007,GO:0042594,GO:0044419,GO:0050896,GO:0051704,GO:0051716,GO:0071496 ko:K07736 ko00000,ko03000 Bacteria 2GKSU@201174,COG1329@1,COG1329@2 NA|NA|NA K transcriptional regulator MAG.T12.14_02564 452652.KSE_34500 4.2e-09 68.2 Kitasatospora Bacteria 2E56G@1,2GK9W@201174,2M3DR@2063,32ZZ6@2 NA|NA|NA MAG.T12.14_02565 1122247.C731_0827 6.8e-95 353.6 Mycobacteriaceae Bacteria 234EX@1762,2GKFS@201174,COG0745@1,COG0745@2 NA|NA|NA K COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain MAG.T12.14_02566 43759.JNWK01000017_gene7629 4.4e-81 308.5 Actinobacteria senX3 GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009405,GO:0009987,GO:0016020,GO:0016310,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044464,GO:0046777,GO:0051704,GO:0071704,GO:0071944,GO:1901564 2.7.13.3 ko:K07636,ko:K07768,ko:K11383 ko02020,map02020 M00434,M00443,M00505 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 2GJY7@201174,COG5002@1,COG5002@2 NA|NA|NA T Histidine kinase MAG.T12.14_02567 1463855.JOHV01000011_gene4088 6.5e-61 240.7 Actinobacteria phoU ko:K02039 ko00000 Bacteria 2GKAD@201174,COG0704@1,COG0704@2 NA|NA|NA P Plays a role in the regulation of phosphate uptake MAG.T12.14_02568 644283.Micau_5680 1.7e-139 502.7 Micromonosporales mshA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016740,GO:0016757,GO:0016758,GO:0044237,GO:0044249,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659 2.4.1.250 ko:K15521 ko00000,ko01000 Bacteria 2GJ57@201174,4D8PR@85008,COG0438@1,COG0438@2 NA|NA|NA M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway MAG.T12.14_02569 1169161.KB897713_gene6602 1e-43 183.3 Actinobacteria Bacteria 2AZ39@1,2GMCY@201174,31R9K@2 NA|NA|NA S Putative bacterial sensory transduction regulator MAG.T12.14_02570 1385519.N801_04205 2.1e-131 475.7 Intrasporangiaceae Bacteria 2GS79@201174,4FFP0@85021,COG3547@1,COG3547@2 NA|NA|NA L Transposase MAG.T12.14_02571 1101188.KI912157_gene87 1.6e-21 109.8 Actinobacteria Bacteria 2EKKY@1,2I2JI@201174,33EAR@2 NA|NA|NA MAG.T12.14_02573 1035308.AQYY01000002_gene68 6.8e-29 135.2 Bacteria Bacteria COG1652@1,COG1652@2,COG3170@1,COG3170@2 NA|NA|NA S positive regulation of growth rate MAG.T12.14_02574 134676.ACPL_5887 3.5e-15 88.2 Micromonosporales Bacteria 2E4ST@1,2GSCH@201174,32ZM5@2,4DEKN@85008 NA|NA|NA S Putative Flp pilus-assembly TadE/G-like MAG.T12.14_02575 196162.Noca_2227 4.5e-15 87.8 Propionibacteriales Bacteria 2GRCJ@201174,4DSH3@85009,COG4961@1,COG4961@2 NA|NA|NA U overlaps another CDS with the same product name MAG.T12.14_02576 110319.CF8_1721 3.6e-41 175.6 Propionibacteriales Bacteria 2DVVA@1,2IHH0@201174,32V07@2,4DRC3@85009 NA|NA|NA MAG.T12.14_02578 526225.Gobs_0675 9e-21 106.7 Actinobacteria Bacteria 2I36X@201174,COG4961@1,COG4961@2 NA|NA|NA U overlaps another CDS with the same product name MAG.T12.14_02580 397278.JOJN01000013_gene2572 3e-50 205.7 Propionibacteriales ko:K12511 ko00000,ko02044 Bacteria 2HZTC@201174,4DRIG@85009,COG2064@1,COG2064@2 NA|NA|NA NU type II secretion system protein MAG.T12.14_02581 1385519.N801_09660 2.3e-52 212.6 Intrasporangiaceae Bacteria 2GN6E@201174,4FHCH@85021,COG4965@1,COG4965@2 NA|NA|NA U Type II secretion system (T2SS), protein F MAG.T12.14_02582 110319.CF8_2349 3.2e-110 405.6 Propionibacteriales ko:K02283 ko00000,ko02035,ko02044 Bacteria 2GKKJ@201174,4DWY1@85009,COG4962@1,COG4962@2 NA|NA|NA U PFAM type II secretion system protein E MAG.T12.14_02583 110319.CF8_2348 2.7e-39 169.1 Propionibacteriales Bacteria 2I57A@201174,4DWY4@85009,COG1192@1,COG1192@2 NA|NA|NA D Involved in chromosome partitioning MAG.T12.14_02584 196162.Noca_2220 8.4e-29 134.0 Propionibacteriales Bacteria 2HIQE@201174,4DWST@85009,COG1261@1,COG1261@2 NA|NA|NA NO SAF MAG.T12.14_02587 1435356.Y013_20760 3.3e-19 100.9 Nocardiaceae Bacteria 2GQV1@201174,4G3V1@85025,COG4877@1,COG4877@2 NA|NA|NA MAG.T12.14_02588 1869.MB27_31595 1.9e-98 365.9 Micromonosporales f42a Bacteria 2GM0Z@201174,4DBBQ@85008,COG0330@1,COG0330@2 NA|NA|NA O prohibitin homologues MAG.T12.14_02589 479433.Caci_7070 1.1e-288 998.8 Actinobacteria lepA GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 ko:K03596 ko05134,map05134 ko00000,ko00001 Bacteria 2GJAB@201174,COG0481@1,COG0481@2 NA|NA|NA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner MAG.T12.14_02590 675635.Psed_2013 4.5e-23 113.6 Pseudonocardiales rpsT GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030234,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0042979,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050790,GO:0065003,GO:0065007,GO:0065009,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02968 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IQ73@201174,4E5HA@85010,COG0268@1,COG0268@2 NA|NA|NA J Binds directly to 16S ribosomal RNA MAG.T12.14_02591 479433.Caci_7073 4.8e-40 172.2 Actinobacteria holA 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 2GNMZ@201174,COG1466@1,COG1466@2 NA|NA|NA L DNA polymerase III delta subunit MAG.T12.14_02592 994479.GL877878_gene2770 1.6e-93 350.9 Pseudonocardiales comEC ko:K02238 M00429 ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 Bacteria 2GJGR@201174,4DXGV@85010,COG0658@1,COG0658@2,COG2333@1,COG2333@2 NA|NA|NA S DNA internalization-related competence protein ComEC Rec2 MAG.T12.14_02593 1122138.AQUZ01000017_gene6611 6e-28 131.3 Propionibacteriales comEA ko:K02237 M00429 ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 Bacteria 2IQDC@201174,4DRFZ@85009,COG1555@1,COG1555@2 NA|NA|NA L Helix-hairpin-helix motif MAG.T12.14_02594 1386089.N865_01635 1.8e-35 156.0 Intrasporangiaceae plsY 2.3.1.15 ko:K03977,ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004,ko03009 Bacteria 2IF8Y@201174,4FG1E@85021,COG0344@1,COG0344@2 NA|NA|NA I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP MAG.T12.14_02595 1289387.AUKW01000018_gene2044 8.5e-63 247.3 Actinobacteria Bacteria 2GIUV@201174,COG1307@1,COG1307@2 NA|NA|NA S DegV family MAG.T12.14_02596 1504319.GM45_5885 3.1e-99 368.2 unclassified Actinobacteria (class) leuS 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 Bacteria 2GJI1@201174,3UWBT@52018,COG0495@1,COG0495@2 NA|NA|NA J Leucyl-tRNA synthetase, Domain 2 MAG.T12.14_02597 931627.MycrhDRAFT_4343 4.1e-218 764.2 Mycobacteriaceae rne GO:0006139,GO:0006364,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 3.1.26.12 ko:K08300,ko:K08301 ko03018,map03018 M00394 ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 Bacteria 2342K@1762,2GMM5@201174,COG1530@1,COG1530@2 NA|NA|NA J ribonuclease, Rne Rng family MAG.T12.14_02598 1048339.KB913029_gene4852 1.3e-32 145.6 Frankiales rplU GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02888 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IQ9A@201174,4ET3X@85013,COG0261@1,COG0261@2 NA|NA|NA J This protein binds to 23S rRNA in the presence of protein L20 MAG.T12.14_02599 471856.Jden_1651 6.7e-35 152.9 Actinobacteria rpmA GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904 ko:K02899 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IQDI@201174,COG0211@1,COG0211@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL27 family MAG.T12.14_02600 1123322.KB904724_gene1934 3.6e-179 634.8 Actinobacteria obg GO:0000287,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0032991,GO:0036211,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046777,GO:0046872,GO:0071704,GO:0071944,GO:1901564,GO:1990904 ko:K03979 ko00000,ko01000,ko03009 Bacteria 2GISB@201174,COG0536@1,COG0536@2 NA|NA|NA S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control MAG.T12.14_02601 105425.BBPL01000002_gene6561 4.3e-124 451.4 Streptacidiphilus proB GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 Bacteria 2GM8U@201174,2NG7R@228398,COG0263@1,COG0263@2 NA|NA|NA E Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase MAG.T12.14_02602 500153.JOEK01000011_gene1945 1.3e-155 556.2 Actinobacteria proA GO:0003674,GO:0003824,GO:0004350,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016620,GO:0016903,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 iLJ478.TM0293,iNJ661.Rv2427c,iYO844.BSU13130 Bacteria 2GISA@201174,COG0014@1,COG0014@2 NA|NA|NA E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate MAG.T12.14_02604 1123024.AUII01000008_gene1827 3.9e-75 287.7 Pseudonocardiales nadD GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18,3.6.1.55 ko:K00969,ko:K03574 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 Bacteria 2GMFZ@201174,4E0CB@85010,COG1057@1,COG1057@2 NA|NA|NA H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) MAG.T12.14_02605 351607.Acel_0763 4.2e-44 185.7 Frankiales Bacteria 2GNGN@201174,4EWPJ@85013,COG1316@1,COG1316@2 NA|NA|NA K LytR cell envelope-related transcriptional attenuator MAG.T12.14_02606 1306174.JODP01000011_gene6740 3e-39 167.9 Actinobacteria rsfS GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113 2.7.7.18 ko:K00969,ko:K09710 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000,ko03009 Bacteria 2IKZ3@201174,COG0799@1,COG0799@2 NA|NA|NA S Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation MAG.T12.14_02607 253839.SSNG_02327 7.5e-57 227.3 Actinobacteria gpmB GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0044237 3.1.3.73,3.1.3.85 ko:K02226,ko:K22306 ko00860,ko01100,map00860,map01100 M00122 R04594,R11173 RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJYU@201174,COG0406@1,COG0406@2 NA|NA|NA G Belongs to the phosphoglycerate mutase family MAG.T12.14_02609 590998.Celf_0702 8.8e-14 83.2 Actinobacteria Bacteria 2EGDD@1,2GR3X@201174,33A58@2 NA|NA|NA S Phospholipase_D-nuclease N-terminal MAG.T12.14_02611 1146883.BLASA_1226 4.3e-114 417.9 Bacteria Bacteria COG0457@1,COG0457@2,COG3012@1,COG3012@2 NA|NA|NA S peptidyl-tyrosine sulfation MAG.T12.14_02612 1151122.AQYD01000006_gene1984 3.7e-23 115.2 Bacteria 3.1.31.1 ko:K01174 ko00000,ko01000 Bacteria COG1525@1,COG1525@2 NA|NA|NA L nuclease MAG.T12.14_02617 1463879.JOHP01000007_gene550 2e-07 61.6 Actinobacteria Bacteria 2CC1Y@1,2H69C@201174,3221K@2 NA|NA|NA K Transcription factor WhiB MAG.T12.14_02619 1035308.AQYY01000001_gene2706 3.6e-28 132.5 Peptococcaceae Bacteria 1UHSZ@1239,25H2T@186801,267I3@186807,COG2856@1,COG2856@2 NA|NA|NA E Zn peptidase MAG.T12.14_02621 106370.Francci3_2360 1.6e-07 62.8 Actinobacteria Bacteria 2E3KC@1,2GQQS@201174,32YIM@2 NA|NA|NA S Domain of unknown function (DUF4913) MAG.T12.14_02622 1464048.JNZS01000015_gene3724 2.2e-140 506.1 Micromonosporales Bacteria 2GNQ7@201174,4D94E@85008,COG3505@1,COG3505@2 NA|NA|NA U Type IV secretory pathway, VirD4 components MAG.T12.14_02623 1394178.AWOO02000006_gene3482 1.1e-142 513.5 Streptosporangiales traD ko:K12071 ko00000,ko02044 3.A.7.11.1 Bacteria 2I70J@201174,4EN6Y@85012,COG0433@1,COG0433@2 NA|NA|NA S COG0433 Predicted ATPase MAG.T12.14_02624 1394178.AWOO02000006_gene3481 1e-24 119.8 Streptosporangiales Bacteria 28IPW@1,2HQJM@201174,2Z8PQ@2,4EN0Y@85012 NA|NA|NA MAG.T12.14_02625 1121924.ATWH01000005_gene2551 1.6e-25 121.7 Actinobacteria Bacteria 2BAGM@1,2H8NG@201174,323X7@2 NA|NA|NA MAG.T12.14_02626 1137268.AZXF01000040_gene3328 6.9e-22 109.8 Bacteria ko:K06218 ko00000,ko02048 Bacteria COG2026@1,COG2026@2 NA|NA|NA DJ nuclease activity MAG.T12.14_02627 710696.Intca_0789 1.7e-137 496.1 Intrasporangiaceae Bacteria 2GS79@201174,4FFP0@85021,COG3547@1,COG3547@2 NA|NA|NA L Transposase MAG.T12.14_02630 457425.XNR_2969 2.2e-81 310.5 Actinobacteria Bacteria 2GNFI@201174,COG0583@1,COG0583@2 NA|NA|NA K DNA-binding transcription factor activity MAG.T12.14_02631 101510.RHA1_ro11282 2e-120 439.1 Nocardiaceae Bacteria 2GKXH@201174,4G1SK@85025,COG2842@1,COG2842@2 NA|NA|NA S AAA domain MAG.T12.14_02632 101510.RHA1_ro11283 1e-189 670.2 Nocardiaceae ko:K07497 ko00000 Bacteria 2HITH@201174,4FZG5@85025,COG2801@1,COG2801@2 NA|NA|NA L Transposition protein MAG.T12.14_02633 101510.RHA1_ro11284 7.5e-63 247.3 Actinobacteria Bacteria 2BSDG@1,2I51E@201174,32MFF@2 NA|NA|NA S Evidence 4 Homologs of previously reported genes of MAG.T12.14_02634 1123322.KB904669_gene3601 1.5e-37 161.8 Actinobacteria dnaB GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0030312,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 ko00000,ko00001,ko01000,ko03032 Bacteria 2GKXQ@201174,COG0305@1,COG0305@2 NA|NA|NA L Participates in initiation and elongation during chromosome replication MAG.T12.14_02635 105420.BBPO01000021_gene5733 1.2e-40 172.6 Streptacidiphilus yngJ GO:0000062,GO:0000166,GO:0003674,GO:0003824,GO:0003995,GO:0004085,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005759,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009605,GO:0009719,GO:0009725,GO:0009987,GO:0009991,GO:0010033,GO:0014070,GO:0016020,GO:0016042,GO:0016043,GO:0016054,GO:0016491,GO:0016627,GO:0017076,GO:0019395,GO:0019605,GO:0019626,GO:0019752,GO:0022607,GO:0030258,GO:0030554,GO:0031090,GO:0031667,GO:0031960,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033218,GO:0033539,GO:0033993,GO:0034440,GO:0036094,GO:0042221,GO:0042594,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046359,GO:0046395,GO:0046459,GO:0048037,GO:0048545,GO:0050660,GO:0050662,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051384,GO:0052890,GO:0055114,GO:0065003,GO:0070013,GO:0071704,GO:0071840,GO:0072329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901567,GO:1901575,GO:1901681 1.3.8.1,1.3.99.12 ko:K00248,ko:K11410,ko:K18244 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 Bacteria 2GMEM@201174,2NFEH@228398,COG1960@1,COG1960@2 NA|NA|NA I Acyl-CoA dehydrogenase, C-terminal domain MAG.T12.14_02636 469383.Cwoe_5648 7.3e-58 231.1 Rubrobacteria 5.1.3.3 ko:K01785 ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130 M00632 R01602,R10619 RC00563 ko00000,ko00001,ko00002,ko01000 Bacteria 2HQKA@201174,4CS5Q@84995,COG2017@1,COG2017@2 NA|NA|NA G Aldose 1-epimerase MAG.T12.14_02637 1048339.KB913029_gene1756 9.1e-37 160.6 Actinobacteria Bacteria 28IGY@1,2H6U5@201174,2Z8I9@2 NA|NA|NA MAG.T12.14_02638 879212.DespoDRAFT_01603 7.8e-45 187.6 Desulfobacterales gluQ 6.1.1.17 ko:K01885,ko:K01894 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 Bacteria 1MUN7@1224,2MNAB@213118,2WV4B@28221,42NQ8@68525,COG0008@1,COG0008@2 NA|NA|NA J Belongs to the class-I aminoacyl-tRNA synthetase family MAG.T12.14_02639 479435.Kfla_1567 1.1e-83 317.0 Propionibacteriales tagH 3.6.3.38,3.6.3.40 ko:K09689,ko:K09691,ko:K09693 ko02010,map02010 M00249,M00250,M00251 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.101,3.A.1.103,3.A.1.104 Bacteria 2GIVF@201174,4DPY7@85009,COG1134@1,COG1134@2 NA|NA|NA GM ATPases associated with a variety of cellular activities MAG.T12.14_02640 2002.JOEQ01000052_gene8351 7.1e-76 290.8 Streptosporangiales tagG ko:K09690,ko:K09692 ko02010,map02010 M00250,M00251 ko00000,ko00001,ko00002,ko02000 3.A.1.103,3.A.1.104 Bacteria 2GP5K@201174,4EHWE@85012,COG1682@1,COG1682@2 NA|NA|NA GM ABC-2 type transporter MAG.T12.14_02641 1123320.KB889719_gene7401 3.9e-127 461.5 Actinobacteria purK GO:0000166,GO:0003674,GO:0003824,GO:0004638,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016829,GO:0016830,GO:0016831,GO:0016874,GO:0016879,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034028,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.4.18 ko:K01589 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07404 RC01927 ko00000,ko00001,ko00002,ko01000 iECUMN_1333.ECUMN_0562,iYL1228.KPN_00477 Bacteria 2GJCU@201174,COG0026@1,COG0026@2 NA|NA|NA F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) MAG.T12.14_02642 1896.JOAU01000015_gene2030 2.1e-59 235.3 Actinobacteria purE GO:0008150,GO:0040007 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 iJN678.purE,iNJ661.Rv3275c Bacteria 2IFFD@201174,COG0041@1,COG0041@2 NA|NA|NA F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) MAG.T12.14_02643 1463936.JOJI01000050_gene5841 9e-163 580.1 Actinobacteria ugd 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJQB@201174,COG1004@1,COG1004@2 NA|NA|NA M Belongs to the UDP-glucose GDP-mannose dehydrogenase family MAG.T12.14_02644 446468.Ndas_4413 2.1e-152 545.4 Streptosporangiales 1.3.8.1,1.3.8.7 ko:K00248,ko:K00249 ko00071,ko00280,ko00410,ko00640,ko00650,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map00650,map01100,map01110,map01120,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01178,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00120,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIX8@201174,4EHDP@85012,COG1960@1,COG1960@2 NA|NA|NA I Acyl-CoA dehydrogenase, middle domain MAG.T12.14_02645 1380354.JIAN01000009_gene3741 4.2e-130 471.5 Actinobacteria recD2_4 Bacteria 2GKJW@201174,COG1112@1,COG1112@2 NA|NA|NA L Superfamily I DNA and RNA helicases and helicase subunits MAG.T12.14_02646 2045.KR76_08315 7e-37 161.4 Propionibacteriales ko:K13573 ko00000,ko03051 Bacteria 2IMC4@201174,4DRG9@85009,COG2378@1,COG2378@2 NA|NA|NA K WYL domain MAG.T12.14_02647 1122994.AUFR01000024_gene25 4.9e-146 524.6 Propionibacteriales yuaG ko:K07192 ko04910,map04910 ko00000,ko00001,ko03036,ko04131,ko04147 Bacteria 2GK9I@201174,4DNKB@85009,COG2268@1,COG2268@2 NA|NA|NA S Flotillin MAG.T12.14_02648 397278.JOJN01000017_gene2520 2.8e-21 108.6 Propionibacteriales Bacteria 2EBIV@1,2IHZS@201174,335JA@2,4DRF2@85009 NA|NA|NA MAG.T12.14_02650 330084.JNYZ01000010_gene6967 2.6e-56 224.9 Pseudonocardiales smpB GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0070930,GO:0071704,GO:0097159,GO:1901363,GO:1901564 ko:K03664 ko00000 Bacteria 2GJX1@201174,4E2R0@85010,COG0691@1,COG0691@2 NA|NA|NA O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA MAG.T12.14_02651 768706.Desor_5488 5.8e-31 142.1 Peptococcaceae ko:K21471,ko:K21472 ko00000,ko01000,ko01002,ko01011 Bacteria 1VAC5@1239,25E3G@186801,267BP@186807,COG0739@1,COG0739@2,COG3883@1,COG3883@2 NA|NA|NA M PFAM Peptidase family M23 MAG.T12.14_02652 1048339.KB913029_gene5048 5.2e-82 311.2 Frankiales ftsX GO:0000910,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0007154,GO:0007165,GO:0007166,GO:0008150,GO:0008356,GO:0009274,GO:0009276,GO:0009966,GO:0009987,GO:0010033,GO:0010646,GO:0016020,GO:0016021,GO:0016043,GO:0019221,GO:0022402,GO:0022603,GO:0022607,GO:0023051,GO:0023052,GO:0030312,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0032153,GO:0032506,GO:0034097,GO:0040007,GO:0042173,GO:0042221,GO:0043937,GO:0043938,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051301,GO:0051716,GO:0065007,GO:0070098,GO:0070297,GO:0070887,GO:0071310,GO:0071345,GO:0071840,GO:0071944,GO:0090529,GO:1902531 ko:K09811,ko:K09812 ko02010,map02010 M00256 ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 Bacteria 2GJMA@201174,4ESQ7@85013,COG2177@1,COG2177@2 NA|NA|NA D Part of the ABC transporter FtsEX involved in cellular division MAG.T12.14_02653 446468.Ndas_3723 2.7e-99 368.2 Streptosporangiales ftsE GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019897,GO:0019898,GO:0030145,GO:0030554,GO:0031234,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363 ko:K09811,ko:K09812 ko02010,map02010 M00256 ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 Bacteria 2GJE1@201174,4EG9N@85012,COG2884@1,COG2884@2 NA|NA|NA D ATPases associated with a variety of cellular activities MAG.T12.14_02654 526225.Gobs_1233 4.7e-154 550.8 Frankiales prfB GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02836 ko00000,ko03012 Bacteria 2GJ0F@201174,4ERJ3@85013,COG1186@1,COG1186@2 NA|NA|NA J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA MAG.T12.14_02656 1463901.JOIY01000024_gene6226 9.1e-207 726.5 Actinobacteria serA 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GJGA@201174,COG0111@1,COG0111@2 NA|NA|NA E Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family MAG.T12.14_02657 1120936.KB907208_gene780 3.8e-74 285.8 Streptosporangiales rfbP Bacteria 2GK0M@201174,4EGMN@85012,COG2148@1,COG2148@2 NA|NA|NA M Bacterial sugar transferase MAG.T12.14_02658 979556.MTES_0953 1.3e-53 217.2 Bacteria wcoF Bacteria COG0438@1,COG0438@2 NA|NA|NA M transferase activity, transferring glycosyl groups MAG.T12.14_02659 590998.Celf_3031 9e-45 186.4 Actinobacteria tagD 2.7.7.39 ko:K00980 ko00564,map00564 R00856 RC00002 ko00000,ko00001,ko01000 Bacteria 2GKU1@201174,COG0615@1,COG0615@2 NA|NA|NA IM Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose MAG.T12.14_02660 1068980.ARVW01000001_gene6598 8.8e-54 217.2 Actinobacteria Bacteria 2GNFE@201174,COG0558@1,COG0558@2 NA|NA|NA I Belongs to the CDP-alcohol phosphatidyltransferase class-I family MAG.T12.14_02662 1449069.JMLO01000017_gene3331 3.8e-84 319.3 Actinobacteria Bacteria 2C825@1,2IGR2@201174,32RK8@2 NA|NA|NA MAG.T12.14_02663 590998.Celf_3037 4.1e-75 288.5 Actinobacteria Bacteria 2IG08@201174,COG1216@1,COG1216@2 NA|NA|NA M Glycosyltransferase, group 2 family protein MAG.T12.14_02666 298655.KI912266_gene787 1.2e-142 513.1 Frankiales Bacteria 2GNQB@201174,4ETFP@85013,COG3547@1,COG3547@2 NA|NA|NA L transposase IS116 IS110 IS902 family protein MAG.T12.14_02667 469371.Tbis_3586 1.8e-16 92.4 Actinobacteria Bacteria 2B9QR@1,2H7N9@201174,3233A@2 NA|NA|NA MAG.T12.14_02669 42256.RradSPS_0358 4.8e-133 481.9 Rubrobacteria ko:K03556 ko00000,ko03000 Bacteria 2HENR@201174,4CPC9@84995,COG2909@1,COG2909@2 NA|NA|NA K helix_turn_helix, Lux Regulon MAG.T12.14_02670 1172188.KB911822_gene695 2.9e-15 87.8 Intrasporangiaceae Bacteria 2DNVA@1,2GRAT@201174,32ZBE@2,4FJSY@85021 NA|NA|NA MAG.T12.14_02671 543632.JOJL01000004_gene4174 3.7e-34 152.1 Micromonosporales Bacteria 2EJNG@1,2H04Y@201174,33DDC@2,4DM96@85008 NA|NA|NA S Domain of unknown function (DUF4386) MAG.T12.14_02672 1280390.CBQR020000100_gene2320 3.2e-90 338.6 Paenibacillaceae Bacteria 1TSWF@1239,274FR@186822,4HANV@91061,COG0604@1,COG0604@2 NA|NA|NA C Zinc-binding dehydrogenase MAG.T12.14_02673 67267.JNXT01000003_gene4090 1.8e-09 68.6 Actinobacteria Bacteria 2B1UQ@1,2GTR9@201174,31UAQ@2 NA|NA|NA MAG.T12.14_02674 765911.Thivi_2384 4.9e-23 115.2 Chromatiales MA20_05910 ko:K03668,ko:K09914 ko00000 Bacteria 1NGG1@1224,1S7JT@1236,1WYQQ@135613,COG3187@1,COG3187@2 NA|NA|NA O META domain MAG.T12.14_02675 935866.JAER01000004_gene3859 1.6e-37 161.8 Propionibacteriales Bacteria 2E5NA@1,2IQ91@201174,330D3@2,4DRUP@85009 NA|NA|NA S Domain of unknown function (DUF4287) MAG.T12.14_02676 1385519.N801_00635 1.2e-82 313.5 Intrasporangiaceae Bacteria 2GIS3@201174,4FGCG@85021,COG0604@1,COG0604@2 NA|NA|NA C Zinc-binding dehydrogenase MAG.T12.14_02678 1108045.GORHZ_150_00010 3e-50 205.3 Actinobacteria Bacteria 2IMPX@201174,2ZF5I@2,arCOG07533@1 NA|NA|NA S Domain of unknown function (DUF4386) MAG.T12.14_02679 1206101.AZXC01000010_gene23 5.1e-83 314.7 Actinobacteria Bacteria 2GIS3@201174,COG0604@1,COG0604@2 NA|NA|NA C alcohol dehydrogenase MAG.T12.14_02680 1146883.BLASA_2357 1.4e-82 313.2 Actinobacteria ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GN8P@201174,COG1131@1,COG1131@2 NA|NA|NA V ABC transporter MAG.T12.14_02681 1211815.CBYP010000005_gene232 1.4e-17 97.4 Actinobacteria Bacteria 2GVAC@201174,COG1277@1,COG1277@2 NA|NA|NA S ABC-type transport system involved in multi-copper enzyme maturation permease component MAG.T12.14_02682 356851.JOAN01000021_gene2322 1.5e-29 137.1 Micromonosporales Bacteria 2GMDB@201174,4DAZM@85008,COG1670@1,COG1670@2 NA|NA|NA J Acetyltransferase (GNAT) domain MAG.T12.14_02685 710696.Intca_0346 1.4e-214 752.3 Actinobacteria nagC ko:K02003,ko:K02565,ko:K15545 M00258 ko00000,ko00002,ko02000,ko03000 3.A.1 Bacteria 2ICG2@201174,COG1321@1,COG1321@2 NA|NA|NA K iron dependent repressor MAG.T12.14_02687 446468.Ndas_2917 6.3e-19 100.1 Streptosporangiales ko:K06975 ko00000 Bacteria 2GQNP@201174,4EKDK@85012,COG2388@1,COG2388@2 NA|NA|NA S GCN5-related N-acetyl-transferase MAG.T12.14_02688 335543.Sfum_1471 6.5e-237 827.0 Syntrophobacterales glgX 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 ko00000,ko00001,ko00002,ko01000 CBM48,GH13 Bacteria 1MU19@1224,2MQ9F@213462,2WKFS@28221,42P3J@68525,COG1523@1,COG1523@2 NA|NA|NA G Belongs to the glycosyl hydrolase 13 family MAG.T12.14_02690 1283283.ATXA01000008_gene3121 1.3e-11 75.9 Actinobacteria rnhA 3.1.26.4,4.1.1.44 ko:K01607,ko:K03469 ko00362,ko01100,ko01120,ko01220,ko03030,map00362,map01100,map01120,map01220,map03030 R03470 RC00938 ko00000,ko00001,ko01000,ko03032 Bacteria 2IM93@201174,COG0599@1,COG0599@2 NA|NA|NA S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity MAG.T12.14_02691 222534.KB893671_gene3402 7.6e-44 183.7 Frankiales merR2 Bacteria 2GM67@201174,4ESCD@85013,COG0789@1,COG0789@2 NA|NA|NA K SMART regulatory protein, MerR MAG.T12.14_02692 1123320.KB889679_gene2403 1e-43 182.6 Actinobacteria yitW ko:K02612 ko00360,ko01120,map00360,map01120 R09838 RC02690 ko00000,ko00001 Bacteria 2IKUH@201174,COG2151@1,COG2151@2 NA|NA|NA J metal-sulfur cluster biosynthetic enzyme MAG.T12.14_02693 471852.Tcur_2229 5.2e-51 207.2 Streptosporangiales iscU ko:K04488 ko00000 Bacteria 2IHY9@201174,4EIUC@85012,COG0822@1,COG0822@2 NA|NA|NA C NifU-like N terminal domain MAG.T12.14_02694 471852.Tcur_2228 5e-163 580.9 Streptosporangiales sufS GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 Bacteria 2GIVK@201174,4EHYF@85012,COG0520@1,COG0520@2 NA|NA|NA E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine MAG.T12.14_02695 1155714.KB891988_gene2109 5.3e-112 410.6 Actinobacteria sufC ko:K09013 ko00000,ko02000 Bacteria 2GKB7@201174,COG0396@1,COG0396@2 NA|NA|NA O FeS assembly ATPase SufC MAG.T12.14_02696 1944.JOAZ01000005_gene1991 4.5e-30 137.1 Streptomyces griseus group hcaC ko:K05710 ko00360,ko01120,ko01220,map00360,map01120,map01220 M00545 R06782,R06783 RC00098 br01602,ko00000,ko00001,ko00002 Bacteria 2IQK7@201174,41AUI@629295,COG2146@1,COG2146@2 NA|NA|NA P Rieske-like [2Fe-2S] domain MAG.T12.14_02698 351607.Acel_1135 3.4e-141 507.7 Frankiales sufB ko:K07033,ko:K09014 ko00000 Bacteria 2GKCZ@201174,4ERKY@85013,COG0719@1,COG0719@2 NA|NA|NA O TIGRFAM FeS assembly protein SufB MAG.T12.14_02699 1278308.KB907085_gene36 7.3e-11 73.6 Microbacteriaceae glxI 4.4.1.5 ko:K01759 ko00620,map00620 R02530 RC00004,RC00740 ko00000,ko00001,ko01000 Bacteria 2GVCV@201174,4FSM4@85023,COG0346@1,COG0346@2 NA|NA|NA E Glyoxalase-like domain MAG.T12.14_02700 710696.Intca_0155 8.2e-60 237.3 Intrasporangiaceae 3.5.1.104 ko:K22278 ko00000,ko01000 Bacteria 2HEQK@201174,4FHJZ@85021,COG0726@1,COG0726@2 NA|NA|NA G Polysaccharide deacetylase MAG.T12.14_02701 935839.JAGJ01000007_gene3163 1.5e-106 392.5 Promicromonosporaceae gluA 3.6.3.21 ko:K02028,ko:K10008 ko02010,map02010 M00233,M00236 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3,3.A.1.3.9 Bacteria 2GIZW@201174,4F3U5@85017,COG1126@1,COG1126@2 NA|NA|NA E ATPases associated with a variety of cellular activities MAG.T12.14_02702 1122933.JNIY01000003_gene1070 1.2e-117 429.5 Cellulomonadaceae gluB ko:K10005 ko02010,map02010 M00233 ko00000,ko00001,ko00002,ko02000 3.A.1.3.9 Bacteria 2GJH8@201174,4F1V2@85016,COG0834@1,COG0834@2 NA|NA|NA ET Bacterial periplasmic substrate-binding proteins MAG.T12.14_02703 1122933.JNIY01000003_gene1069 3.3e-78 298.1 Cellulomonadaceae glnM GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015318,GO:0015711,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1903825,GO:1905039 ko:K10006,ko:K10040 ko02010,map02010 M00228,M00233 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.9 Bacteria 2GNUR@201174,4F2G2@85016,COG0765@1,COG0765@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component MAG.T12.14_02704 1122933.JNIY01000003_gene1068 5.2e-76 291.2 Cellulomonadaceae gluD ko:K02029,ko:K10007 ko02010,map02010 M00233,M00236 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.9 Bacteria 2GNBH@201174,4F29Z@85016,COG0765@1,COG0765@2 NA|NA|NA E Binding-protein-dependent transport system inner membrane component MAG.T12.14_02705 67275.JOAP01000018_gene1118 3.7e-18 100.1 Actinobacteria Bacteria 2IBN6@201174,COG1502@1,COG1502@2 NA|NA|NA I PLD-like domain MAG.T12.14_02706 656024.FsymDg_1517 0.0 1077.4 Frankiales ko:K03727 ko00000,ko01000 Bacteria 2GJSV@201174,4ES27@85013,COG4581@1,COG4581@2 NA|NA|NA L DEAD DEAH box helicase MAG.T12.14_02707 287986.DV20_10395 8.8e-59 234.6 Pseudonocardiales ko:K02027,ko:K17329 ko02010,map02010 M00207,M00606 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.33 Bacteria 2GKM8@201174,4DYH5@85010,COG1653@1,COG1653@2 NA|NA|NA G Bacterial extracellular solute-binding protein MAG.T12.14_02708 743718.Isova_2471 5.4e-68 264.2 Promicromonosporaceae msrA 1.8.4.11 ko:K07304 ko00000,ko01000 Bacteria 2GJ1S@201174,4F34W@85017,COG0225@1,COG0225@2 NA|NA|NA O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine MAG.T12.14_02709 1048339.KB913029_gene142 3e-52 212.2 Frankiales Bacteria 2GMVS@201174,4ESHM@85013,COG2755@1,COG2755@2 NA|NA|NA E GDSL-like Lipase/Acylhydrolase MAG.T12.14_02711 479433.Caci_0641 9.9e-22 109.0 Actinobacteria Bacteria 2E5A7@1,2IQ7Z@201174,3302F@2 NA|NA|NA S Domain of unknown function (DUF4287) MAG.T12.14_02712 593907.Celgi_0646 4.4e-46 191.8 Cellulomonadaceae ko:K06377 ko00000 Bacteria 2GNCK@201174,4F210@85016,COG4760@1,COG4760@2 NA|NA|NA S Bax inhibitor 1 like MAG.T12.14_02713 1120949.KB903301_gene6329 4.1e-105 388.3 Micromonosporales Bacteria 2GP09@201174,4D8JX@85008,COG0111@1,COG0111@2 NA|NA|NA EH D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding MAG.T12.14_02715 935866.JAER01000019_gene3959 1.9e-63 248.8 Propionibacteriales 3.5.1.88 ko:K01462 ko00000,ko01000 Bacteria 2HMJS@201174,4DNQP@85009,COG0242@1,COG0242@2 NA|NA|NA J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions MAG.T12.14_02716 1504319.GM45_3080 4.5e-38 164.5 Actinobacteria ko:K03567 ko02026,map02026 ko00000,ko00001,ko03000 Bacteria 2IS2K@201174,COG2716@1,COG2716@2 NA|NA|NA E ACT domain MAG.T12.14_02718 1906.SFRA_25950 1.2e-100 373.2 Actinobacteria ppx GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 R03409 RC00002 ko00000,ko00001,ko01000 Bacteria 2GJBN@201174,COG0248@1,COG0248@2 NA|NA|NA FP Ppx GppA phosphatase MAG.T12.14_02719 1184609.KILIM_002_00280 1.2e-57 229.6 Dermatophilaceae ppx2 3.6.1.11,3.6.1.40 ko:K01524,ko:K09009 ko00230,map00230 R03409 RC00002 ko00000,ko00001,ko01000 Bacteria 2I8CS@201174,4F6XI@85018,COG1507@1,COG1507@2 NA|NA|NA S Protein of unknown function (DUF501) MAG.T12.14_02721 263358.VAB18032_26245 2.7e-86 325.5 Micromonosporales pknD ko:K02030 M00236 ko00000,ko00002,ko02000 3.A.1.3 Bacteria 2GJQW@201174,4DCDW@85008,COG0834@1,COG0834@2 NA|NA|NA ET ABC-type amino acid transport signal transduction systems, periplasmic component domain MAG.T12.14_02722 1463856.JOHY01000004_gene6505 1.3e-20 107.1 Actinobacteria 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 2GJ6V@201174,COG0204@1,COG0204@2 NA|NA|NA I Acyltransferase MAG.T12.14_02723 525904.Tter_2417 1.7e-10 72.0 Bacteria ko:K09932 ko00000 Bacteria COG3224@1,COG3224@2 NA|NA|NA MAG.T12.14_02724 134676.ACPL_4177 2.7e-59 236.5 Actinobacteria Bacteria 2ID0G@201174,COG2199@1,COG3706@2 NA|NA|NA T GGDEF domain MAG.T12.14_02726 93220.LV28_08510 2e-210 738.8 Burkholderiaceae recQ GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008270,GO:0009295,GO:0009378,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017116,GO:0017117,GO:0030894,GO:0032392,GO:0032508,GO:0032991,GO:0032993,GO:0033202,GO:0033554,GO:0034641,GO:0042623,GO:0043138,GO:0043140,GO:0043142,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1904949 3.6.4.12 ko:K03654 ko03018,map03018 ko00000,ko00001,ko01000,ko03400 Bacteria 1K353@119060,1MVGG@1224,2VH8W@28216,COG0514@1,COG0514@2 NA|NA|NA L ATP-dependent DNA helicase RecQ MAG.T12.14_02727 1146883.BLASA_3489 9.6e-99 367.1 Actinobacteria Bacteria 2H3MV@201174,COG0210@1,COG0210@2,COG1112@1,COG1112@2 NA|NA|NA L Type III restriction enzyme res subunit MAG.T12.14_02728 751945.Theos_1037 1.6e-170 605.9 Deinococcus-Thermus ko:K02575 ko00910,map00910 M00615 ko00000,ko00001,ko00002,ko02000 2.A.1.8 Bacteria 1WJJV@1297,COG2223@1,COG2223@2 NA|NA|NA P Major Facilitator Superfamily MAG.T12.14_02729 1123386.AUIW01000006_gene1638 2.4e-147 528.9 Deinococcus-Thermus narK ko:K02575 ko00910,map00910 M00615 ko00000,ko00001,ko00002,ko02000 2.A.1.8 Bacteria 1WJ7D@1297,COG2223@1,COG2223@2 NA|NA|NA P Major Facilitator Superfamily MAG.T12.14_02730 390989.JOEG01000004_gene3799 4e-82 312.0 Micromonosporales mog 2.10.1.1,2.8.1.12,4.6.1.17 ko:K03635,ko:K03637,ko:K03750 ko00790,ko01100,ko04122,map00790,map01100,map04122 R09395,R09735,R11372 RC02507,RC03425,RC03462 ko00000,ko00001,ko01000 Bacteria 2GP1B@201174,4DBSX@85008,COG0303@1,COG0303@2,COG0521@1,COG0521@2 NA|NA|NA H Probable molybdopterin binding domain MAG.T12.14_02731 66373.JOFQ01000008_gene441 6.9e-42 177.9 Actinobacteria mobA 2.7.7.77 ko:K03752 ko00790,ko01100,map00790,map01100 R11581 ko00000,ko00001,ko01000 Bacteria 2GJVE@201174,COG0746@1,COG0746@2 NA|NA|NA H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor MAG.T12.14_02732 1380393.JHVP01000002_gene1835 1.7e-44 185.7 Frankiales moaC 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 R11372 RC03425 ko00000,ko00001,ko01000 Bacteria 2IHR6@201174,4ESM0@85013,COG0315@1,COG0315@2 NA|NA|NA H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) MAG.T12.14_02733 208444.JNYY01000006_gene6922 1e-67 263.8 Pseudonocardiales moaE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.7.7.80,2.8.1.11,2.8.1.12,4.6.1.17 ko:K03635,ko:K03637,ko:K21147 ko00790,ko01100,ko04122,map00790,map01100,map04122 R07459,R07461,R09395,R11372 RC00043,RC02507,RC03425 ko00000,ko00001,ko01000 Bacteria 2II28@201174,4DZNU@85010,COG0314@1,COG0314@2,COG0521@1,COG0521@2 NA|NA|NA H TIGRFAM molybdenum cofactor synthesis MAG.T12.14_02734 1120936.KB907219_gene3177 2.8e-117 428.7 Streptosporangiales moaA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0030312,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0071944,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.22,4.6.1.17 ko:K03639,ko:K20967 ko00790,ko01100,ko04122,map00790,map01100,map04122 R09394,R11372 RC03420,RC03425 ko00000,ko00001,ko01000 Bacteria 2GN0V@201174,4EGC1@85012,COG2896@1,COG2896@2 NA|NA|NA H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate MAG.T12.14_02735 1121952.ATXT01000015_gene350 3.3e-08 64.3 Microbacteriaceae moaD 2.8.1.12 ko:K03636,ko:K21142 ko00790,ko01100,ko04122,map00790,map01100,map04122 R09395 RC02507 ko00000,ko00001,ko01000 Bacteria 2HSWM@201174,4FQNM@85023,COG1977@1,COG1977@2 NA|NA|NA H ThiS family MAG.T12.14_02736 478801.Ksed_19270 2e-81 309.7 Actinobacteria ko:K03321 ko00000,ko02000 2.A.53.3 Bacteria 2H1V9@201174,COG0659@1,COG0659@2 NA|NA|NA P Molybdate transporter of MFS superfamily MAG.T12.14_02737 1386089.N865_11320 5.4e-99 368.2 Intrasporangiaceae Bacteria 2GN56@201174,4FFV2@85021,COG1835@1,COG1835@2 NA|NA|NA I Acyltransferase family MAG.T12.14_02738 33898.JRHJ01000011_gene4893 2.6e-207 729.2 Actinobacteria gabT 2.6.1.19,2.6.1.22 ko:K00823,ko:K07250 ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648,R04188 RC00006,RC00062,RC00160 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 2GKVH@201174,COG0160@1,COG0160@2,COG2334@1,COG2334@2 NA|NA|NA E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family MAG.T12.14_02739 1032480.MLP_27620 7e-40 170.2 Propionibacteriales Bacteria 2AWFS@1,2IMS0@201174,31NC1@2,4DVM9@85009 NA|NA|NA MAG.T12.14_02740 1120950.KB892707_gene4971 4.7e-101 374.4 Propionibacteriales lgt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008961,GO:0009058,GO:0009059,GO:0009249,GO:0009898,GO:0009987,GO:0010467,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051604,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0140096,GO:1901564,GO:1901566,GO:1901576 2.1.1.199 ko:K03438,ko:K13292 ko00000,ko01000,ko03009 Bacteria 2GKSS@201174,4DP3T@85009,COG0682@1,COG0682@2 NA|NA|NA M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins MAG.T12.14_02741 1504319.GM45_1285 2.9e-39 169.1 unclassified Actinobacteria (class) pknE_1 Bacteria 2GKH8@201174,3UWV7@52018,COG1651@1,COG1651@2 NA|NA|NA O Thioredoxin MAG.T12.14_02742 35754.JNYJ01000014_gene4756 1.1e-51 209.9 Micromonosporales Bacteria 2GMVK@201174,4DD9S@85008,COG4243@1,COG4243@2 NA|NA|NA S VKc MAG.T12.14_02743 469371.Tbis_1452 2.3e-81 308.9 Pseudonocardiales trpA GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 Bacteria 2GN6T@201174,4E01I@85010,COG0159@1,COG0159@2 NA|NA|NA E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate MAG.T12.14_02744 1451261.AS96_10855 5.3e-148 530.4 Microbacteriaceae trpB GO:0000162,GO:0003674,GO:0003824,GO:0004834,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 Bacteria 2GM7Z@201174,4FKK8@85023,COG0133@1,COG0133@2 NA|NA|NA E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine MAG.T12.14_02745 234267.Acid_3077 5.4e-143 514.6 Acidobacteria ko:K15314 ko01059,ko01130,map01059,map01130 M00824,M00825 R11435 ko00000,ko00001,ko00002,ko01008 Bacteria 3Y347@57723,COG0304@1,COG0304@2,COG3321@1,COG3321@2,COG4221@1,COG4221@2 NA|NA|NA Q Acyl transferase domain MAG.T12.14_02746 1089455.MOPEL_080_00430 0.0 1407.1 Dermatophilaceae Bacteria 2GIZP@201174,4F7M0@85018,COG4770@1,COG4770@2,COG4799@1,COG4799@2 NA|NA|NA I Acetyl-CoA carboxylase, central region MAG.T12.14_02747 234267.Acid_3076 9.8e-26 124.0 Acidobacteria 2.7.8.7 ko:K00997,ko:K06133 ko00770,map00770 R01625 RC00002 ko00000,ko00001,ko01000 Bacteria 3Y8HB@57723,COG2091@1,COG2091@2 NA|NA|NA H 4'-phosphopantetheinyl transferase superfamily MAG.T12.14_02748 889378.Spiaf_2269 8e-149 533.9 Bacteria amyA GO:0003674,GO:0003824,GO:0004553,GO:0004556,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016160,GO:0016787,GO:0016798,GO:0044424,GO:0044464 3.2.1.1 ko:K01176 ko00500,ko01100,ko04973,map00500,map01100,map04973 R02108,R02112,R11262 ko00000,ko00001,ko01000 GH13 iECH74115_1262.ECH74115_2702,iECSP_1301.ECSP_2532,iECs_1301.ECs2666,iG2583_1286.G2583_2378,iSF_1195.SF1970 Bacteria COG0366@1,COG0366@2 NA|NA|NA G hydrolase activity, hydrolyzing O-glycosyl compounds MAG.T12.14_02749 1123237.Salmuc_04555 2.8e-39 168.7 Alphaproteobacteria Bacteria 1MXXT@1224,2U9WZ@28211,COG1961@1,COG1961@2 NA|NA|NA L Site-specific recombinases, DNA invertase Pin homologs MAG.T12.14_02751 1283283.ATXA01000009_gene3212 9.6e-26 124.4 Actinobacteria Bacteria 2DRK0@1,2I7B6@201174,33C4R@2 NA|NA|NA MAG.T12.14_02752 653045.Strvi_8468 4.9e-35 154.1 Actinobacteria Bacteria 2DWHI@1,2IKAK@201174,340CG@2 NA|NA|NA MAG.T12.14_02753 653045.Strvi_2601 4.2e-271 940.6 Actinobacteria Bacteria 2GK5Z@201174,COG0582@1,COG0582@2 NA|NA|NA L Belongs to the 'phage' integrase family MAG.T12.14_02754 100226.SCO4349 5.5e-186 657.5 Actinobacteria Bacteria 2CA8D@1,2I8TK@201174,2ZA16@2 NA|NA|NA MAG.T12.14_02755 653045.Strvi_8465 1.1e-189 669.5 Actinobacteria ko:K03733,ko:K04763 ko00000,ko03036 Bacteria 2GX0Z@201174,COG4974@1,COG4974@2 NA|NA|NA L 'Phage' integrase family MAG.T12.14_02757 1048339.KB913029_gene4866 1.8e-120 439.5 Frankiales folC 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJP2@201174,4ERQF@85013,COG0285@1,COG0285@2 NA|NA|NA H Mur ligase, middle domain protein MAG.T12.14_02758 1120936.KB907209_gene1847 6.3e-11 73.6 Bacteria Bacteria 2EHND@1,33BE5@2 NA|NA|NA S Protein of unknown function (DUF4233) MAG.T12.14_02759 1380356.JNIK01000001_gene2188 3.8e-48 197.6 Frankiales ndk GO:0003674,GO:0003824,GO:0004518,GO:0004550,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006464,GO:0006468,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016787,GO:0016788,GO:0018995,GO:0019205,GO:0019538,GO:0019637,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0034641,GO:0036211,GO:0042025,GO:0043170,GO:0043412,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044464,GO:0046483,GO:0046777,GO:0046939,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072527,GO:0090304,GO:0090305,GO:1901360,GO:1901564 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 iNJ661.Rv2445c Bacteria 2IFBU@201174,4ESUM@85013,COG0105@1,COG0105@2 NA|NA|NA F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate MAG.T12.14_02760 543632.JOJL01000008_gene5922 1.4e-120 439.5 Micromonosporales ppk2 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008976,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0044237 2.7.4.1 ko:K22468 ko00190,ko03018,map00190,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 2GKRN@201174,4DBU4@85008,COG2326@1,COG2326@2 NA|NA|NA S Polyphosphate kinase 2 (PPK2) MAG.T12.14_02761 471852.Tcur_1544 3.9e-300 1036.9 Streptosporangiales Bacteria 2GJY1@201174,4EFRZ@85012,COG1032@1,COG1032@2 NA|NA|NA C Elongator protein 3, MiaB family, Radical SAM MAG.T12.14_02762 1380356.JNIK01000001_gene2193 6.2e-65 254.2 Frankiales Bacteria 2GIS7@201174,4ESGF@85013,COG5011@1,COG5011@2 NA|NA|NA S Uncharacterized protein conserved in bacteria (DUF2344) MAG.T12.14_02765 994479.GL877878_gene233 1.3e-19 102.8 Pseudonocardiales mhpC Bacteria 2I2GI@201174,4E2R5@85010,COG2267@1,COG2267@2 NA|NA|NA I Alpha beta hydrolase MAG.T12.14_02766 1341646.CBMO010000130_gene3119 5.2e-40 171.4 Mycobacteriaceae otsB GO:0000287,GO:0003674,GO:0003824,GO:0004805,GO:0005488,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0009058,GO:0009266,GO:0009311,GO:0009312,GO:0009409,GO:0009628,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0033554,GO:0034637,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0046351,GO:0046872,GO:0050896,GO:0051716,GO:0070413,GO:0070415,GO:0070417,GO:0071704,GO:1901576 2.4.1.15,2.4.1.347,3.1.3.12 ko:K00697,ko:K01087,ko:K16055 ko00500,ko01100,map00500,map01100 R02737,R02778 RC00005,RC00017,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 GT20 iE2348C_1286.E2348C_2018,iECED1_1282.ECED1_2163,iECIAI39_1322.ECIAI39_1155,iECS88_1305.ECS88_1952,iLF82_1304.LF82_1582,iNRG857_1313.NRG857_09495 Bacteria 233CH@1762,2I3PZ@201174,COG1877@1,COG1877@2 NA|NA|NA G Removes the phosphate from trehalose 6-phosphate to produce free trehalose MAG.T12.14_02767 743718.Isova_2618 2.7e-136 492.3 Promicromonosporaceae otsA GO:0003674,GO:0003824,GO:0003825,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016311,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0016788,GO:0016791,GO:0030145,GO:0030312,GO:0033554,GO:0034637,GO:0035251,GO:0040007,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046527,GO:0046872,GO:0046914,GO:0047260,GO:0050896,GO:0051716,GO:0070413,GO:0071704,GO:0071944,GO:1901576 2.4.1.15,2.4.1.347,3.1.3.12 ko:K00697,ko:K16055 ko00500,ko01100,map00500,map01100 R02737,R02778 RC00005,RC00017,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 GT20 Bacteria 2GMX7@201174,4F40E@85017,COG0380@1,COG0380@2 NA|NA|NA G Glycosyltransferase family 20 MAG.T12.14_02768 44060.JODL01000020_gene4906 4.9e-214 750.4 Actinobacteria 1.3.1.86 ko:K17829 ko00650,ko01120,ko01130,ko01200,map00650,map01120,map01130,map01200 R09738 RC00076 ko00000,ko00001,ko01000 Bacteria 2GKFF@201174,COG0604@1,COG0604@2 NA|NA|NA C reductase MAG.T12.14_02769 1048339.KB913029_gene3420 1.7e-49 202.2 Frankiales mce 5.1.99.1 ko:K05606 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R02765,R09979 RC00780,RC02739 ko00000,ko00001,ko00002,ko01000 Bacteria 2IIPR@201174,4ESUP@85013,COG0346@1,COG0346@2 NA|NA|NA E PFAM Glyoxalase bleomycin resistance protein dioxygenase MAG.T12.14_02770 345341.KUTG_06459 2.4e-167 595.1 Pseudonocardiales fadA4 GO:0003674,GO:0003824,GO:0003988,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044403,GO:0044419,GO:0044464,GO:0046395,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:0075136,GO:1901575 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GJAC@201174,4DYM7@85010,COG0183@1,COG0183@2 NA|NA|NA I Belongs to the thiolase family MAG.T12.14_02771 1894.JOER01000007_gene6468 5.8e-108 397.5 Actinobacteria ko:K07588 ko00000,ko01000 Bacteria 2GME8@201174,COG1703@1,COG1703@2 NA|NA|NA E LAO AO transport system ATPase MAG.T12.14_02773 1003195.SCAT_2410 1.2e-20 106.7 Actinobacteria ligT GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008104,GO:0008150,GO:0009966,GO:0010646,GO:0010738,GO:0023051,GO:0033036,GO:0034237,GO:0044424,GO:0044444,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051018,GO:0051179,GO:0065007,GO:1902531 3.1.4.58 ko:K01975 ko00000,ko01000,ko03016 Bacteria 2GNDN@201174,COG1514@1,COG1514@2 NA|NA|NA J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester MAG.T12.14_02774 998088.B565_1091 1.5e-24 119.4 Proteobacteria Bacteria 1NKFS@1224,COG3832@1,COG3832@2 NA|NA|NA S Activator of Hsp90 ATPase homolog 1-like protein MAG.T12.14_02775 1380393.JHVP01000002_gene1784 1.5e-140 505.8 Frankiales mdh 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 Bacteria 2GN5S@201174,4ESBM@85013,COG0039@1,COG0039@2 NA|NA|NA C Catalyzes the reversible oxidation of malate to oxaloacetate MAG.T12.14_02776 1120950.KB892760_gene5727 6.2e-10 70.5 Bacteria Bacteria 2DRQP@1,33CNM@2 NA|NA|NA S Protein of unknown function (DUF3017) MAG.T12.14_02777 269800.Tfu_2571 2.9e-115 421.8 Streptosporangiales folD GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0040007,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJZS@201174,4EH3U@85012,COG0190@1,COG0190@2 NA|NA|NA H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate MAG.T12.14_02778 633149.Bresu_2234 7.2e-65 254.2 Caulobacterales MA20_05625 Bacteria 1MU9Y@1224,2KF3K@204458,2TUH0@28211,COG0647@1,COG0647@2 NA|NA|NA G Hydrolase MAG.T12.14_02779 44060.JODL01000002_gene2206 1.2e-211 742.7 Actinobacteria purH GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 iHN637.CLJU_RS04230,iJN678.purH Bacteria 2GJWU@201174,COG0138@1,COG0138@2 NA|NA|NA F Bifunctional purine biosynthesis protein PurH MAG.T12.14_02780 43354.JOIJ01000010_gene2460 3.3e-64 251.5 Pseudonocardiales purN GO:0000287,GO:0003674,GO:0005488,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019752,GO:0034641,GO:0042558,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0046483,GO:0046653,GO:0046872,GO:0051186,GO:0071704,GO:1901360,GO:1901564 2.1.2.2,2.1.2.3,3.5.4.10 ko:K00602,ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04325,R04326,R04560 RC00026,RC00197,RC00263,RC00456,RC01128 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2H8QB@201174,4DY8H@85010,COG0299@1,COG0299@2 NA|NA|NA F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate MAG.T12.14_02781 1120950.KB892760_gene5721 1.7e-22 114.0 Propionibacteriales ko:K07148 ko00000 Bacteria 2GKA8@201174,4DQSU@85009,COG2311@1,COG2311@2 NA|NA|NA S Membrane MAG.T12.14_02783 1306174.JODP01000013_gene7453 6e-101 374.0 Actinobacteria ko:K01995 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 2GMEE@201174,COG0411@1,COG0411@2 NA|NA|NA E ABC transporter MAG.T12.14_02784 1306174.JODP01000013_gene7452 2.2e-91 342.0 Actinobacteria ko:K01996 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 2GKSQ@201174,COG0410@1,COG0410@2 NA|NA|NA E ABC transporter MAG.T12.14_02785 269800.Tfu_1187 1.2e-66 260.0 Actinobacteria ydfK ko:K07150 ko00000 Bacteria 2GM75@201174,COG1811@1,COG1811@2 NA|NA|NA S Na channel or pump MAG.T12.14_02786 1043205.AFYF01000075_gene2080 2.1e-36 158.7 Intrasporangiaceae ydiI Bacteria 2IKTU@201174,4FGPR@85021,COG2050@1,COG2050@2 NA|NA|NA Q protein possibly involved in aromatic compounds catabolism MAG.T12.14_02788 40571.JOEA01000002_gene4983 2.8e-18 99.8 Pseudonocardiales Bacteria 2B1K4@1,2I2R4@201174,32S9C@2,4E7BQ@85010 NA|NA|NA S Protein of unknown function (DUF3068) MAG.T12.14_02789 1003195.SCAT_1131 2.3e-83 315.8 Actinobacteria Bacteria 2GJSF@201174,COG0500@1,COG2226@2 NA|NA|NA Q methyltransferase MAG.T12.14_02790 1323361.JPOC01000040_gene4233 1.3e-80 306.2 Nocardiaceae narH 1.7.5.1 ko:K00371 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000 5.A.3.1 Bacteria 2GJ8P@201174,4FUZU@85025,COG1140@1,COG1140@2 NA|NA|NA C Nitrate reductase beta subunit MAG.T12.14_02791 1127134.NOCYR_4275 3.1e-45 188.7 Nocardiaceae narJ GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016530,GO:0022607,GO:0034622,GO:0042126,GO:0042128,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0051131,GO:0065003,GO:0071704,GO:0071840,GO:0071941,GO:0140104,GO:2001057 ko:K00373,ko:K17052 ko02020,map02020 ko00000,ko00001,ko02000 5.A.3.8 iE2348C_1286.E2348C_1350,iECABU_c1320.ECABU_c15020,iECIAI1_1343.ECIAI1_1469,iECO103_1326.ECO103_1331,iECO111_1330.ECO111_1557,iECW_1372.ECW_m1594,iEKO11_1354.EKO11_2354,iLF82_1304.LF82_1462,iNRG857_1313.NRG857_06280,iSSON_1240.SSON_1659,iWFL_1372.ECW_m1594,iYO844.BSU37260,ic_1306.c1687 Bacteria 2IAQV@201174,4FWCV@85025,COG2180@1,COG2180@2 NA|NA|NA C Nitrate reductase MAG.T12.14_02792 1429046.RR21198_1930 3e-88 331.6 Nocardiaceae narI GO:0001666,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006950,GO:0008150,GO:0008152,GO:0008940,GO:0009055,GO:0009061,GO:0009325,GO:0009628,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016661,GO:0019645,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0036293,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044799,GO:0045333,GO:0046906,GO:0048037,GO:0050896,GO:0055114,GO:0070469,GO:0070470,GO:0070482,GO:0071944,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901363,GO:1902494,GO:1990204 1.7.5.1 ko:K00370,ko:K00374,ko:K02575 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00615,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 2.A.1.8,5.A.3.1 iEC042_1314.EC042_1594,iECABU_c1320.ECABU_c17020,iECUMN_1333.ECUMN_1718,iSF_1195.SF1230,ic_1306.c1897 Bacteria 2GJVI@201174,4FWVI@85025,COG2181@1,COG2181@2 NA|NA|NA C nitrate reductase, gamma subunit MAG.T12.14_02793 398513.BBNG_01119 2.4e-26 124.8 Bifidobacteriales Bacteria 2IHSV@201174,4D0ZF@85004,COG1917@1,COG1917@2 NA|NA|NA S Cupin 2, conserved barrel domain protein MAG.T12.14_02794 1385520.N802_11095 1.8e-92 345.5 Actinobacteria Bacteria 2AAWD@1,2IG0D@201174,3109H@2 NA|NA|NA S Alkylmercury lyase MAG.T12.14_02795 882083.SacmaDRAFT_4675 6.1e-44 184.5 Actinobacteria Bacteria 2IAWJ@201174,COG2345@1,COG2345@2 NA|NA|NA K Transcriptional regulator MAG.T12.14_02796 754252.PFREUD_23710 3.5e-94 352.1 Actinobacteria eryK Bacteria 2IJFZ@201174,COG2124@1,COG2124@2 NA|NA|NA C Cytochrome P450 MAG.T12.14_02797 1276920.ADIAG_02147 1.7e-26 125.2 Actinobacteria Bacteria 2GS7C@201174,COG4309@1,COG4309@2 NA|NA|NA S Uncharacterized conserved protein (DUF2249) MAG.T12.14_02798 1211815.CBYP010000005_gene232 6.5e-20 105.1 Actinobacteria Bacteria 2GVAC@201174,COG1277@1,COG1277@2 NA|NA|NA S ABC-type transport system involved in multi-copper enzyme maturation permease component MAG.T12.14_02801 1217658.F987_02722 8.4e-16 91.7 Moraxellaceae Bacteria 1QVSC@1224,1SRBM@1236,3NR5W@468,COG3979@1,COG3979@2 NA|NA|NA S chitinase MAG.T12.14_02802 710111.FraQA3DRAFT_3461 7e-25 120.6 Actinobacteria ko:K03088 ko00000,ko03021 Bacteria 2IKVM@201174,COG1595@1,COG1595@2 NA|NA|NA K belongs to the sigma-70 factor family, ECF subfamily MAG.T12.14_02804 1123052.AUDF01000002_gene687 1.3e-21 109.8 Microbacteriaceae Bacteria 2B212@1,2HTBX@201174,31UHT@2,4FSXA@85023 NA|NA|NA MAG.T12.14_02805 1380370.JIBA01000011_gene3047 7.7e-150 536.6 Intrasporangiaceae ko:K04763 ko00000,ko03036 Bacteria 2ID5W@201174,4FFEX@85021,COG4974@1,COG4974@2 NA|NA|NA L Belongs to the 'phage' integrase family MAG.T12.14_02806 1123251.ATWM01000007_gene2333 1.1e-27 129.4 Intrasporangiaceae Bacteria 2E8MQ@1,2ISX4@201174,332Z5@2,4FHDD@85021 NA|NA|NA S Ribbon-helix-helix protein, copG family MAG.T12.14_02807 1429046.RR21198_1564 1.7e-24 118.2 Nocardiaceae Bacteria 2BGV5@1,2HM66@201174,32AUV@2,4G51E@85025 NA|NA|NA MAG.T12.14_02812 1035308.AQYY01000002_gene962 1.8e-35 156.8 Bacteria Bacteria COG5340@1,COG5340@2 NA|NA|NA K Psort location Cytoplasmic, score MAG.T12.14_02816 2074.JNYD01000003_gene3711 1.7e-34 154.1 Pseudonocardiales Bacteria 2GPWU@201174,4EAZ9@85010,COG0323@1,COG0323@2 NA|NA|NA L PFAM Relaxase mobilization nuclease family protein MAG.T12.14_02819 1197706.AKKK01000058_gene1428 3.1e-32 146.7 Actinobacteria ko:K03497 ko00000,ko03000,ko03036,ko04812 Bacteria 2I9VV@201174,COG1475@1,COG1475@2 NA|NA|NA K ParB domain protein nuclease MAG.T12.14_02821 1108045.GORHZ_171_00530 2e-22 111.3 Actinobacteria ko:K21495 ko00000,ko02048 Bacteria 2GSHN@201174,COG4691@1,COG4691@2 NA|NA|NA S Plasmid stability protein MAG.T12.14_02822 1121019.AUMN01000003_gene1021 5.8e-52 210.3 Actinobacteria vapC ko:K07062 ko00000,ko01000,ko02048 Bacteria 2IS29@201174,COG1487@1,COG1487@2 NA|NA|NA S Toxic component of a toxin-antitoxin (TA) module. An RNase MAG.T12.14_02823 35754.JNYJ01000011_gene741 2.5e-22 111.3 Micromonosporales yozG ko:K07727 ko00000,ko03000 Bacteria 2GQZM@201174,4DEY7@85008,COG3655@1,COG3655@2 NA|NA|NA K Cro/C1-type HTH DNA-binding domain MAG.T12.14_02824 1043205.AFYF01000045_gene2925 2.7e-08 65.9 Intrasporangiaceae Bacteria 2ET1V@1,2GZYR@201174,33KK0@2,4FI7B@85021 NA|NA|NA S Protein of unknown function (DUF2975) MAG.T12.14_02825 1172179.AUKV01000005_gene5828 3e-24 118.2 Actinobacteria ko:K03088 ko00000,ko03021 Bacteria 2IKVM@201174,COG1595@1,COG1595@2 NA|NA|NA K belongs to the sigma-70 factor family, ECF subfamily MAG.T12.14_02827 455632.SGR_872 2.3e-10 71.6 Actinobacteria ko:K03088 ko00000,ko03021 Bacteria 2IRNG@201174,COG1595@1,COG1595@2 NA|NA|NA K belongs to the sigma-70 factor family, ECF subfamily MAG.T12.14_02831 266940.Krad_3828 1e-124 453.8 Actinobacteria ko:K13527 ko03050,map03050 M00342 ko00000,ko00001,ko00002,ko03051 Bacteria 2IA0X@201174,COG1222@1,COG1222@2 NA|NA|NA O ATPase family associated with various cellular activities (AAA) MAG.T12.14_02832 351607.Acel_1618 6.6e-126 456.8 Frankiales cysD 1.8.4.10,1.8.4.8,2.7.7.4 ko:K00390,ko:K00957 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R02021,R04929 RC00007,RC02809,RC02862,RC02889 ko00000,ko00001,ko00002,ko01000 Bacteria 2GN85@201174,4ERIE@85013,COG0175@1,COG0175@2 NA|NA|NA EH Sulfate adenylyltransferase MAG.T12.14_02833 446462.Amir_1235 1.5e-148 532.7 Pseudonocardiales cysN 2.7.1.25,2.7.7.4 ko:K00955,ko:K00956 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00509,R00529,R04928,R04929 RC00002,RC00078,RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJDX@201174,4DYZW@85010,COG2895@1,COG2895@2 NA|NA|NA P Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily MAG.T12.14_02834 1713.JOFV01000005_gene2127 2.7e-105 389.0 Cellulomonadaceae cysG GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009628,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.13.11.79,1.3.1.76,2.1.1.107,4.99.1.4 ko:K02302,ko:K02303,ko:K02304,ko:K04719 ko00740,ko00860,ko01100,ko01110,ko01120,map00740,map00860,map01100,map01110,map01120 M00121 R02864,R03194,R03947,R09083 RC00003,RC00435,RC00871,RC01012,RC01034,RC02413 ko00000,ko00001,ko00002,ko01000 iECIAI1_1343.ECIAI1_3507,iECSE_1348.ECSE_3630,iEcE24377_1341.EcE24377A_3838,iJN746.PP_3999,iPC815.YPO0158 Bacteria 2GK3B@201174,4F0HX@85016,COG0007@1,COG0007@2 NA|NA|NA H PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase MAG.T12.14_02835 1463856.JOHY01000003_gene5078 5.2e-22 111.7 Actinobacteria Bacteria 2GS51@201174,COG2138@1,COG2138@2 NA|NA|NA P cobalamin (vitamin B12) biosynthesis CbiX protein MAG.T12.14_02836 1123322.KB904735_gene1568 5.5e-100 371.3 Actinobacteria patB 4.4.1.8 ko:K14155 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 R00782,R01286,R02408,R04941 RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko01000,ko01007 Bacteria 2GJFQ@201174,COG1168@1,COG1168@2 NA|NA|NA E Aminotransferase, class I MAG.T12.14_02837 1122622.ATWJ01000012_gene997 3.7e-18 96.7 Intrasporangiaceae Bacteria 2E460@1,2GQGS@201174,32Z20@2,4FHQE@85021 NA|NA|NA MAG.T12.14_02838 1120936.KB907216_gene3853 2.2e-206 725.3 Streptosporangiales sucA GO:0000287,GO:0003674,GO:0003824,GO:0004591,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016624,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0019842,GO:0022900,GO:0030312,GO:0030976,GO:0032991,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0048037,GO:0050439,GO:0050662,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234 1.2.4.2,4.1.1.71 ko:K00164,ko:K01616 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1248c,iSSON_1240.SSON_0677,iYL1228.KPN_00732 Bacteria 2GIU6@201174,4EHHS@85012,COG0508@1,COG0508@2,COG0567@1,COG0567@2 NA|NA|NA C 2-oxoglutarate dehydrogenase C-terminal MAG.T12.14_02839 1449976.KALB_6759 4.1e-91 341.7 Pseudonocardiales alx ko:K05794 ko00000 Bacteria 2GIWU@201174,4DYPS@85010,COG0861@1,COG0861@2 NA|NA|NA P PFAM Integral membrane protein TerC MAG.T12.14_02840 710696.Intca_1671 0.0 1086.2 Intrasporangiaceae uvrB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 ko:K03702,ko:K08999 ko03420,map03420 ko00000,ko00001,ko03400 Bacteria 2GJ03@201174,4FF7R@85021,COG0556@1,COG0556@2 NA|NA|NA L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage MAG.T12.14_02841 1111729.ATYV01000023_gene1471 6.3e-50 204.1 Corynebacteriaceae coaE GO:0005575,GO:0005622,GO:0005623,GO:0009579,GO:0016020,GO:0034357,GO:0042651,GO:0044424,GO:0044436,GO:0044464 2.7.1.24 ko:K00859,ko:K02096,ko:K02286,ko:K02290,ko:K02630,ko:K05378,ko:K05379,ko:K05380 ko00196,ko00770,ko01100,map00196,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko00194,ko01000 Bacteria 22MZB@1653,2GN96@201174,COG0237@1,COG0237@2 NA|NA|NA F Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A MAG.T12.14_02842 479435.Kfla_3091 3.2e-32 146.4 Propionibacteriales ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GJV2@201174,4DQVU@85009,COG2244@1,COG2244@2 NA|NA|NA S polysaccharide biosynthetic process MAG.T12.14_02843 1283287.KB822576_gene3718 1.3e-145 522.7 Propionibacteriales rpsA GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 ko:K02945 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GJAK@201174,4DPIM@85009,COG0539@1,COG0539@2 NA|NA|NA J ribosomal protein MAG.T12.14_02845 1246995.AFR_16520 1.5e-140 506.9 Micromonosporales 2.4.1.12 ko:K00694 ko00500,ko01100,ko02026,map00500,map01100,map02026 R02889 RC00005 ko00000,ko00001,ko01000,ko01003,ko02000 4.D.3.1.2,4.D.3.1.5,4.D.3.1.6 GT2 Bacteria 2GKFI@201174,4D8PJ@85008,COG1215@1,COG1215@2 NA|NA|NA M Glycosyltransferases, probably involved in cell wall biogenesis MAG.T12.14_02846 1089545.KB913037_gene8298 6.2e-33 149.4 Pseudonocardiales ko:K03556 ko00000,ko03000 Bacteria 2IBM2@201174,4E973@85010,COG2197@1,COG2197@2,COG2909@1,COG2909@2 NA|NA|NA KT helix_turn_helix, Lux Regulon MAG.T12.14_02847 1961.JOAK01000019_gene6876 1e-113 417.2 Actinobacteria nagE 2.7.1.193,2.7.1.199 ko:K02803,ko:K02804,ko:K20116,ko:K20117,ko:K20118 ko00010,ko00520,ko02060,map00010,map00520,map02060 M00267,M00809 R02738,R05199 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.13,4.A.1.1.14,4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7,4.A.1.1.9 Bacteria 2GKPM@201174,COG1263@1,COG1263@2 NA|NA|NA G Phosphotransferase System MAG.T12.14_02848 290399.Arth_3515 1.1e-17 95.5 Actinobacteria 2.7.1.193 ko:K02803 ko00520,ko02060,map00520,map02060 M00267 R05199 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7 Bacteria 2IQIB@201174,COG1264@1,COG1264@2 NA|NA|NA G phosphotransferase system MAG.T12.14_02849 419947.MRA_2836 9.8e-139 500.4 Mycobacteriaceae ko:K07497 ko00000 Bacteria 236H8@1762,2I8NF@201174,COG2801@1,COG2801@2 NA|NA|NA L PFAM Integrase, catalytic MAG.T12.14_02850 543632.JOJL01000119_gene275 3e-113 414.8 Actinobacteria ko:K02450 M00331 ko00000,ko00002,ko02044 9.B.42 Bacteria 2IA4V@201174,COG3267@1,COG3267@2 NA|NA|NA U Type II secretory pathway component ExeA MAG.T12.14_02851 253839.SSNG_07093 2.3e-10 72.0 Actinobacteria Bacteria 2ARFZ@1,2IFQT@201174,31GS5@2 NA|NA|NA MAG.T12.14_02854 313589.JNB_00985 3.9e-40 170.6 Intrasporangiaceae Bacteria 2IR8D@201174,4FJD6@85021,COG3339@1,COG3339@2 NA|NA|NA S Conserved Protein MAG.T12.14_02856 1150864.MILUP08_43181 2.1e-14 85.5 Actinobacteria Bacteria 2AW65@1,2INY2@201174,31N15@2 NA|NA|NA MAG.T12.14_02858 1121017.AUFG01000004_gene3201 7.9e-70 270.0 Intrasporangiaceae def 3.5.1.88 ko:K01462 ko00000,ko01000 Bacteria 2GJ87@201174,4FG5A@85021,COG0242@1,COG0242@2 NA|NA|NA J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions MAG.T12.14_02859 1449353.JQMQ01000005_gene829 2e-121 442.2 Streptacidiphilus fmt GO:0003674,GO:0003824,GO:0004479,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006418,GO:0006431,GO:0006464,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019752,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.1.176,2.1.2.9 ko:K00604,ko:K03500 ko00670,ko00970,map00670,map00970 R03940 RC00026,RC00165 ko00000,ko00001,ko01000,ko03009 iECABU_c1320.ECABU_c37050,iECUMN_1333.ECUMN_3761,ic_1306.c4048 Bacteria 2GKH5@201174,2NH3A@228398,COG0223@1,COG0223@2 NA|NA|NA J Formyl transferase, C-terminal domain MAG.T12.14_02860 2045.KR76_14595 4e-110 405.2 Propionibacteriales sun GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.176,5.3.1.9 ko:K01810,ko:K03500 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko03009,ko04147 Bacteria 2GM21@201174,4DP4E@85009,COG0144@1,COG0144@2,COG0781@1,COG0781@2 NA|NA|NA JK Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family MAG.T12.14_02861 1048339.KB913029_gene4006 1.2e-88 332.8 Frankiales rpe GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJZ9@201174,4ERMA@85013,COG0036@1,COG0036@2 NA|NA|NA G Belongs to the ribulose-phosphate 3-epimerase family MAG.T12.14_02862 743718.Isova_1506 3.2e-104 385.2 Promicromonosporaceae ribD GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0008703,GO:0008835,GO:0009058,GO:0009110,GO:0009231,GO:0009451,GO:0009987,GO:0016020,GO:0016070,GO:0016491,GO:0016614,GO:0016616,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0034641,GO:0036094,GO:0040007,GO:0042364,GO:0042726,GO:0042727,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.1.1.193,3.5.4.26 ko:K01498,ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1624,iB21_1397.B21_00366,iECBD_1354.ECBD_3247,iECB_1328.ECB_00362,iECD_1391.ECD_00362,iECED1_1282.ECED1_0437,iECNA114_1301.ECNA114_0391,iECSF_1327.ECSF_0374,iEcolC_1368.EcolC_3219,iJN746.PP_0514,iLF82_1304.LF82_1880,iLJ478.TM1828,iNRG857_1313.NRG857_01945,iYL1228.KPN_00366,ic_1306.c0524 Bacteria 2GKAX@201174,4F42N@85017,COG0117@1,COG0117@2,COG1985@1,COG1985@2 NA|NA|NA H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate MAG.T12.14_02863 1449355.JQNR01000005_gene5307 5.5e-64 250.8 Actinobacteria ribE GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.9,3.5.4.25,4.1.99.12 ko:K00793,ko:K02858,ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00066,R00425,R07281 RC00293,RC00958,RC00960,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS08950 Bacteria 2GKC5@201174,COG0307@1,COG0307@2 NA|NA|NA H riboflavin synthase, alpha MAG.T12.14_02867 446462.Amir_6924 7.1e-97 360.9 Pseudonocardiales nagA 3.5.1.25 ko:K01443 ko00520,ko01130,map00520,map01130 R02059 RC00166,RC00300 ko00000,ko00001,ko01000 Bacteria 2GK1E@201174,4DX8Z@85010,COG1820@1,COG1820@2 NA|NA|NA G Belongs to the metallo-dependent hydrolases superfamily. NagA family MAG.T12.14_02868 263358.VAB18032_00585 2.7e-167 595.5 Micromonosporales yheS_2 ko:K06158,ko:K18230 ko02010,map02010 ko00000,ko00001,ko01504,ko02000,ko03012 3.A.1.120 Bacteria 2GK9S@201174,4DA8K@85008,COG0488@1,COG0488@2 NA|NA|NA S ATPases associated with a variety of cellular activities MAG.T12.14_02869 1078020.KEK_20058 2e-109 402.5 Mycobacteriaceae ko:K02012 ko02010,map02010 M00190 ko00000,ko00001,ko00002,ko02000 3.A.1.10 Bacteria 236RG@1762,2HPZ8@201174,COG1840@1,COG1840@2 NA|NA|NA P Extracellular solute-binding protein MAG.T12.14_02870 66874.JOFS01000005_gene4116 7.4e-116 424.5 Actinobacteria sfuB ko:K02011 ko02010,map02010 M00190 ko00000,ko00001,ko00002,ko02000 3.A.1.10 Bacteria 2GKPT@201174,COG1178@1,COG1178@2 NA|NA|NA P Binding-protein-dependent transport systems inner membrane component MAG.T12.14_02871 1048339.KB913029_gene4017 3.2e-49 201.1 Frankiales rplT GO:0000027,GO:0000900,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0060255,GO:0065003,GO:0065007,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090079,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2000113,GO:2001141 ko:K02887 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IHTN@201174,4ESXY@85013,COG0292@1,COG0292@2 NA|NA|NA J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit MAG.T12.14_02872 1122130.AUHN01000006_gene2126 8.5e-14 82.4 Actinobacteria rpmI GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 ko:K02916 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GQZW@201174,COG0291@1,COG0291@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL35 family MAG.T12.14_02873 1184607.AUCHE_01_00170 1.7e-64 252.3 Dermatophilaceae infC GO:0000049,GO:0001731,GO:0002181,GO:0002183,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006417,GO:0006446,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016020,GO:0016043,GO:0019222,GO:0019538,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032268,GO:0032270,GO:0032790,GO:0032984,GO:0032988,GO:0032991,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043254,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045727,GO:0045948,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065003,GO:0065007,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901193,GO:1901195,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:1904688,GO:1904690,GO:1990856,GO:1990904,GO:2000112,GO:2000765,GO:2000767 ko:K02520 ko00000,ko03012,ko03029 Bacteria 2GJGT@201174,4F6SW@85018,COG0290@1,COG0290@2 NA|NA|NA J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins MAG.T12.14_02874 452652.KSE_15250 1.2e-37 162.5 Kitasatospora Bacteria 2AI3Y@1,2IHSQ@201174,2M2YX@2063,318HW@2 NA|NA|NA MAG.T12.14_02875 1123052.AUDF01000011_gene1510 5.5e-16 91.7 Microbacteriaceae hisA GO:0000105,GO:0003674,GO:0003824,GO:0003949,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.4.19,3.6.1.31,5.3.1.16,5.3.1.24 ko:K01814,ko:K01817,ko:K11755 ko00340,ko00400,ko01100,ko01110,ko01130,ko01230,map00340,map00400,map01100,map01110,map01130,map01230 M00023,M00026 R03509,R04035,R04037,R04640 RC00002,RC00945,RC01055 ko00000,ko00001,ko00002,ko01000 Bacteria 2I4YY@201174,4FKW9@85023,COG0106@1,COG0106@2 NA|NA|NA E SseB protein N-terminal domain MAG.T12.14_02876 1348663.KCH_66760 2.8e-77 296.2 Kitasatospora accD GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009059,GO:0009273,GO:0009987,GO:0016020,GO:0016053,GO:0019752,GO:0032787,GO:0034645,GO:0042546,GO:0043170,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070589,GO:0071554,GO:0071704,GO:0071766,GO:0071767,GO:0071768,GO:0071840,GO:0071944,GO:0072330,GO:1901576 2.1.3.15,6.4.1.2 ko:K01962,ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 Bacteria 2GNP7@201174,2M0IK@2063,COG0777@1,COG0777@2,COG0825@1,COG0825@2 NA|NA|NA I Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit MAG.T12.14_02878 1894.JOER01000030_gene416 1.4e-37 163.3 Actinobacteria Bacteria 2GMRP@201174,COG4758@1,COG4758@2 NA|NA|NA S Cell wall-active antibiotics response 4TMS YvqF MAG.T12.14_02879 369723.Strop_3578 3.9e-14 84.3 Micromonosporales GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 Bacteria 2E65S@1,2IMEQ@201174,330UF@2,4DERM@85008 NA|NA|NA S Domain of unknown function (DUF3817) MAG.T12.14_02880 1210045.ALNP01000011_gene1032 3.6e-25 122.1 Actinobacteria surf1 ko:K14998 ko00000,ko03029 3.D.4.8 Bacteria 2GMGB@201174,COG3346@1,COG3346@2 NA|NA|NA S SURF1-like protein MAG.T12.14_02882 994479.GL877878_gene2035 1.4e-12 79.7 Pseudonocardiales Bacteria 2DRBP@1,2IGPY@201174,33B4I@2,4E5JR@85010 NA|NA|NA S Domain of unknown function (DUF4307) MAG.T12.14_02883 1504319.GM45_3100 5.2e-44 184.1 unclassified Actinobacteria (class) greA GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006354,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0030312,GO:0031323,GO:0031326,GO:0032774,GO:0032784,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 ko:K03624 ko00000,ko03021 Bacteria 2GNZV@201174,3UWPU@52018,COG0782@1,COG0782@2 NA|NA|NA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides MAG.T12.14_02884 526225.Gobs_0935 1.6e-131 476.1 Frankiales ilvA 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 iLJ478.TM0356 Bacteria 2GJAG@201174,4ES0N@85013,COG1171@1,COG1171@2 NA|NA|NA E PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit MAG.T12.14_02885 1435356.Y013_00880 6.6e-93 347.1 Nocardiaceae ung GO:0003674,GO:0003824,GO:0004844,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0097510,GO:0140097,GO:1901360 3.2.2.27 ko:K03648 ko03410,ko05340,map03410,map05340 ko00000,ko00001,ko01000,ko03400 Bacteria 2GJ9Z@201174,4FXPC@85025,COG0692@1,COG0692@2 NA|NA|NA L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine MAG.T12.14_02886 1464048.JNZS01000001_gene197 1e-08 65.9 Micromonosporales apc3 3.5.2.14,3.5.2.9 ko:K01469,ko:K01473 ko00330,ko00480,ko01100,map00330,map00480,map01100 R00251,R03187 RC00553,RC00632 ko00000,ko00001,ko01000 Bacteria 2I2UQ@201174,4DMD8@85008,COG0145@1,COG0145@2 NA|NA|NA EQ MutL protein MAG.T12.14_02887 680646.RMDY18_00050 2.7e-71 276.6 Actinobacteria Bacteria 2DXS1@1,2HAC0@201174,32V40@2 NA|NA|NA MAG.T12.14_02888 426716.JOAJ01000009_gene5889 2.4e-29 135.6 Nocardiaceae Bacteria 2GNQ4@201174,4FUXM@85025,COG5512@1,COG5512@2 NA|NA|NA S Belongs to the UPF0232 family MAG.T12.14_02889 436229.JOEH01000010_gene5297 1.6e-112 412.9 Streptacidiphilus recF GO:0000731,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0018130,GO:0019438,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901576 ko:K03629,ko:K07459 ko03440,map03440 ko00000,ko00001,ko03400 Bacteria 2GJCS@201174,2NGB8@228398,COG1195@1,COG1195@2 NA|NA|NA L AAA domain MAG.T12.14_02890 1123322.KB904669_gene3635 1.4e-113 416.4 Actinobacteria dnaN GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 2GJK3@201174,COG0592@1,COG0592@2 NA|NA|NA L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria MAG.T12.14_02891 1504319.GM45_1735 2.3e-21 107.5 unclassified Actinobacteria (class) dnaA GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006172,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009133,GO:0009135,GO:0009136,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009179,GO:0009180,GO:0009185,GO:0009188,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016311,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046031,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990837 ko:K02313 ko02020,ko04112,map02020,map04112 ko00000,ko00001,ko03032,ko03036 Bacteria 2GJKI@201174,3UW7I@52018,COG0593@1,COG0593@2 NA|NA|NA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids MAG.T12.14_02892 1120960.ATXG01000002_gene2757 1.4e-107 396.4 Microbacteriaceae ko:K06994 ko00000 Bacteria 2GJ5A@201174,4FK7G@85023,COG2409@1,COG2409@2 NA|NA|NA D MMPL family MAG.T12.14_02894 543632.JOJL01000024_gene1982 2.8e-36 158.7 Micromonosporales Bacteria 2IIA5@201174,4DEYA@85008,COG0640@1,COG0640@2 NA|NA|NA K Helix-turn-helix domain MAG.T12.14_02895 1323361.JPOC01000066_gene82 2e-79 303.1 Nocardiaceae ko:K06889 ko00000 Bacteria 2IA0F@201174,4FUH3@85025,COG1073@1,COG1073@2 NA|NA|NA S BAAT / Acyl-CoA thioester hydrolase C terminal MAG.T12.14_02898 2002.JOEQ01000014_gene5323 3.7e-204 718.0 Streptosporangiales Bacteria 2GK5V@201174,4EH63@85012,COG0531@1,COG0531@2 NA|NA|NA E Amino acid permease MAG.T12.14_02899 1048339.KB913029_gene3874 6.8e-90 337.8 Frankiales trmA GO:0000049,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016740,GO:0016741,GO:0019843,GO:0030488,GO:0030696,GO:0030697,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363 2.1.1.190,2.1.1.35 ko:K00557,ko:K03215 ko00000,ko01000,ko03009,ko03016 Bacteria 2GIR3@201174,4ERZK@85013,COG2265@1,COG2265@2 NA|NA|NA J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family MAG.T12.14_02904 196162.Noca_1086 9e-147 527.3 Propionibacteriales resA 3.1.21.5 ko:K01156 ko00000,ko01000,ko02048 Bacteria 2I8IG@201174,4DSXW@85009,COG1061@1,COG1061@2 NA|NA|NA KL Type III restriction enzyme, res subunit MAG.T12.14_02905 110319.CF8_4272 1.1e-52 214.2 Actinobacteria coiA ko:K06198 ko00000 Bacteria 2IPIX@201174,COG4469@1,COG4469@2 NA|NA|NA S Competence protein MAG.T12.14_02909 222534.KB893670_gene3740 1.2e-24 118.6 Frankiales typA GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840 ko:K06207 ko00000 Bacteria 2GJUJ@201174,4ES8A@85013,COG1217@1,COG1217@2 NA|NA|NA T GTP-binding protein TypA MAG.T12.14_02910 1122182.KB903813_gene2505 5.2e-80 305.4 Micromonosporales ko:K02035,ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 2GIUH@201174,4DBF2@85008,COG4166@1,COG4166@2 NA|NA|NA E extracellular solute-binding protein MAG.T12.14_02911 1385520.N802_16405 5.5e-87 327.8 Intrasporangiaceae ko:K02033,ko:K13890,ko:K15581 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00348,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.11,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 2GJ2C@201174,4FEQC@85021,COG0601@1,COG0601@2 NA|NA|NA U ABC transporter (Permease) MAG.T12.14_02912 1123320.KB889719_gene7333 4.6e-73 281.6 Actinobacteria oppC ko:K02034,ko:K15582 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 2GJ9E@201174,COG1173@1,COG1173@2 NA|NA|NA EP PFAM binding-protein-dependent transport systems inner membrane component MAG.T12.14_02914 543632.JOJL01000005_gene4760 1.8e-110 407.1 Actinobacteria Bacteria 2I2TP@201174,COG5002@1,COG5002@2 NA|NA|NA T Histidine kinase MAG.T12.14_02915 543632.JOJL01000005_gene4762 2.8e-23 114.8 Actinobacteria Bacteria 2I2Z1@201174,COG0745@1,COG0745@2 NA|NA|NA T Response regulator receiver MAG.T12.14_02916 1120950.KB892707_gene4712 1e-92 346.7 Propionibacteriales hisG GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 Bacteria 2GNAX@201174,4DNZB@85009,COG0040@1,COG0040@2 NA|NA|NA E ATP phosphoribosyltransferase MAG.T12.14_02917 1121946.AUAX01000008_gene7170 6.2e-28 129.8 Micromonosporales hisE GO:0000105,GO:0000287,GO:0003674,GO:0003824,GO:0004635,GO:0004636,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0043167,GO:0043169,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052803,GO:0071704,GO:0071944,GO:0075136,GO:0075139,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.4.19,3.6.1.31,5.3.1.16 ko:K01523,ko:K01814,ko:K11755 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035,R04037,R04640 RC00002,RC00945,RC01055 ko00000,ko00001,ko00002,ko01000 iECNA114_1301.ECNA114_0880,iECW_1372.ECW_m2186,iEKO11_1354.EKO11_1768,iSB619.SA_RS14110,iUMN146_1321.UM146_06665,iWFL_1372.ECW_m2186,iYO844.BSU34860 Bacteria 2IQ4D@201174,4DF5K@85008,COG0140@1,COG0140@2 NA|NA|NA E Phosphoribosyl-ATP MAG.T12.14_02918 1115803.HMPREF1129_0933 6.9e-50 203.8 Actinobacteria ribH 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 Bacteria 2II1Z@201174,4D5BA@85005,COG0054@1,COG0054@2 NA|NA|NA H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin MAG.T12.14_02919 1179773.BN6_62920 1.6e-13 81.3 Pseudonocardiales ribBA GO:0005575,GO:0005576,GO:0008150,GO:0040007 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1415 Bacteria 2GIWJ@201174,4DXCJ@85010,COG0108@1,COG0108@2,COG0807@1,COG0807@2 NA|NA|NA H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate MAG.T12.14_02920 1120950.KB892708_gene4422 8.8e-63 247.7 Propionibacteriales Bacteria 2GJBZ@201174,4DNGY@85009,COG1994@1,COG1994@2 NA|NA|NA S Belongs to the peptidase M50B family MAG.T12.14_02921 1137269.AZWL01000002_gene6306 4.2e-112 411.4 Actinobacteria trmI GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016426,GO:0016429,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.219,2.1.1.220 ko:K07442 ko00000,ko01000,ko03016 Bacteria 2GJPD@201174,COG2519@1,COG2519@2 NA|NA|NA J Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA MAG.T12.14_02923 460265.Mnod_6097 6.4e-124 451.1 Methylobacteriaceae chrA ko:K07240 ko00000,ko02000 2.A.51.1 Bacteria 1JRJU@119045,1MUBW@1224,2TRXF@28211,COG2059@1,COG2059@2 NA|NA|NA P TIGRFAM chromate transporter, chromate ion transporter (CHR) family MAG.T12.14_02924 134676.ACPL_4271 3.5e-60 237.7 Actinobacteria Bacteria 2IK0B@201174,COG4275@1,COG4275@2 NA|NA|NA S chromate resistance protein MAG.T12.14_02925 591159.ACEZ01000200_gene2508 5.6e-37 160.6 Actinobacteria chrB Bacteria 2IPJU@201174,COG4275@1,COG4275@2 NA|NA|NA S Chromate resistance exported protein MAG.T12.14_02926 1385520.N802_11095 6.9e-87 327.0 Actinobacteria Bacteria 2AAWD@1,2IG0D@201174,3109H@2 NA|NA|NA S Alkylmercury lyase MAG.T12.14_02927 1146883.BLASA_4885 6.6e-129 467.2 Frankiales nirK 1.7.2.1 ko:K00368 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 Bacteria 2GPUP@201174,4ES9Q@85013,COG2132@1,COG2132@2,COG4454@1,COG4454@2 NA|NA|NA Q Multicopper oxidase MAG.T12.14_02931 1041522.MCOL_V200460 2.2e-58 231.9 Mycobacteriaceae trpF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 ko:K09767 ko00000 Bacteria 232N6@1762,2IFIU@201174,COG1666@1,COG1666@2 NA|NA|NA S Belongs to the UPF0234 family MAG.T12.14_02932 411471.SUBVAR_05270 2.1e-48 199.1 Ruminococcaceae pgp GO:0003674,GO:0003824,GO:0004672,GO:0004713,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018108,GO:0018193,GO:0018212,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046777,GO:0071704,GO:0140096,GO:1901564 3.1.3.18 ko:K01091,ko:K07025 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 R01334 RC00017 ko00000,ko00001,ko01000 Bacteria 1V1FQ@1239,24G1U@186801,3WITI@541000,COG0546@1,COG0546@2 NA|NA|NA S Psort location Cytoplasmic, score MAG.T12.14_02933 1051006.HMPREF1162_1975 2.1e-27 128.3 Actinobacteria nuoI 1.6.5.3 ko:K00338,ko:K03615,ko:K05580 ko00190,ko01100,map00190,map01100 M00144,M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2GPSS@201174,COG1143@1,COG1143@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient MAG.T12.14_02934 644283.Micau_5568 9.5e-22 110.2 Micromonosporales nuoC2 1.6.5.3 ko:K00332,ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2GNVP@201174,4DBTZ@85008,COG0852@1,COG0852@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain MAG.T12.14_02935 68170.KL590469_gene1813 8.4e-23 113.6 Pseudonocardiales 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2GJP5@201174,4E3JM@85010,COG0377@1,COG0377@2 NA|NA|NA C NADH ubiquinone oxidoreductase, 20 Kd subunit MAG.T12.14_02937 1283283.ATXA01000007_gene3836 1.2e-14 85.1 Frankiales sdhC ko:K00241,ko:K00247 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00149,M00150,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 Bacteria 2IKU7@201174,4EVCC@85013,COG2009@1,COG2009@2 NA|NA|NA C Succinate dehydrogenase/Fumarate reductase transmembrane subunit MAG.T12.14_02938 105422.BBPM01000015_gene1944 1.2e-46 192.6 Streptacidiphilus sdhD ko:K00242,ko:K00246 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00149,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002 Bacteria 2GNKE@201174,2NI1D@228398,COG2142@1,COG2142@2 NA|NA|NA C Succinate dehydrogenase/Fumarate reductase transmembrane subunit MAG.T12.14_02939 1123320.KB889688_gene406 1.2e-276 958.7 Actinobacteria sdhA GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0043436,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071704,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0072350,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 iE2348C_1286.E2348C_0603,iJN746.PP_4191,iPC815.YPO1111 Bacteria 2GJ45@201174,COG1053@1,COG1053@2 NA|NA|NA C succinate dehydrogenase MAG.T12.14_02940 1463936.JOJI01000013_gene4702 2.2e-110 405.2 Actinobacteria sdhB GO:0000104,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0022904,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0048037,GO:0051536,GO:0051537,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072350,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.3.5.1,1.3.5.4 ko:K00240 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 e_coli_core.b0724,iAF1260.b0724,iBWG_1329.BWG_0583,iEC042_1314.EC042_0742,iECDH10B_1368.ECDH10B_0791,iECDH1ME8569_1439.ECDH1ME8569_0683,iECUMN_1333.ECUMN_0802,iEcDH1_1363.EcDH1_2911,iJO1366.b0724,iJR904.b0724,iY75_1357.Y75_RS03765 Bacteria 2GP9C@201174,COG0479@1,COG0479@2 NA|NA|NA C Succinate dehydrogenase and fumarate reductase iron-sulfur protein MAG.T12.14_02944 1154860.SAG0136_08155 4.7e-20 104.4 Firmicutes Bacteria 1VEXS@1239,2DPQ8@1,332YA@2 NA|NA|NA MAG.T12.14_02947 543632.JOJL01000036_gene3056 1.3e-27 130.2 Actinobacteria ygaU GO:0003674,GO:0005488,GO:0008150,GO:0010035,GO:0010038,GO:0030955,GO:0031420,GO:0035864,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896 ko:K21687 ko00000 GH23 Bacteria 2GR94@201174,COG1652@1,COG1652@2,COG2247@1,COG2247@2 NA|NA|NA M D-alanyl-D-alanine carboxypeptidase MAG.T12.14_02949 105420.BBPO01000022_gene5822 7e-183 646.7 Streptacidiphilus aspC Bacteria 2GJ7R@201174,2NHQV@228398,COG0436@1,COG0436@2 NA|NA|NA E Cys/Met metabolism PLP-dependent enzyme MAG.T12.14_02950 196162.Noca_0672 7.9e-103 380.6 Propionibacteriales murB GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008360,GO:0008762,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0022603,GO:0022604,GO:0030203,GO:0034645,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045229,GO:0048037,GO:0050660,GO:0050662,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0055114,GO:0065007,GO:0065008,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 iECED1_1282.ECED1_4683,iECUMN_1333.ECUMN_4498_AT6,iLF82_1304.LF82_1416,iNRG857_1313.NRG857_19845 Bacteria 2GIV2@201174,4DNF7@85009,COG0812@1,COG0812@2 NA|NA|NA M Cell wall formation MAG.T12.14_02952 1304865.JAGF01000001_gene1598 1.2e-83 316.6 Actinobacteria fnt ko:K06212,ko:K21993 ko00000,ko02000 1.A.16.1.1,1.A.16.1.3,1.A.16.2 Bacteria 2I8DX@201174,COG2116@1,COG2116@2 NA|NA|NA P Formate nitrite transporter MAG.T12.14_02953 1184607.AUCHE_08_00700 2.5e-60 238.8 Dermatophilaceae Bacteria 2GKFS@201174,4F6SG@85018,COG0745@1,COG0745@2 NA|NA|NA K Transcriptional regulatory protein, C terminal MAG.T12.14_02955 1081644.IMCC13023_04080 8.6e-196 690.3 Microbacteriaceae Bacteria 2I7FH@201174,4FRRZ@85023,COG0457@1,COG0457@2 NA|NA|NA S Tetratricopeptide repeat MAG.T12.14_02956 1081644.IMCC13023_04070 3e-46 192.2 Actinobacteria Bacteria 2B8JV@1,2H60Z@201174,321V3@2 NA|NA|NA MAG.T12.14_02959 1122933.JNIY01000003_gene63 8e-48 196.8 Actinobacteria ko:K21429 ko00000,ko01002 Bacteria 2GKWI@201174,COG4894@1,COG4894@2 NA|NA|NA S LURP-one-related MAG.T12.14_02960 675635.Psed_4822 1.2e-88 334.0 Pseudonocardiales Bacteria 2GM17@201174,4DYVE@85010,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor MAG.T12.14_02961 269800.Tfu_0343 3.4e-72 278.1 Streptosporangiales Bacteria 2GIZB@201174,4ENVQ@85012,COG0745@1,COG0745@2 NA|NA|NA T Transcriptional regulatory protein, C terminal MAG.T12.14_02963 1120936.KB907219_gene3210 1e-40 173.7 Streptosporangiales hisE Bacteria 2GJNG@201174,4EITJ@85012,COG0637@1,COG0637@2 NA|NA|NA S Haloacid dehalogenase-like hydrolase MAG.T12.14_02964 1385519.N801_08145 6.2e-93 347.4 Intrasporangiaceae ko:K02003 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GJN6@201174,4FF61@85021,COG1136@1,COG1136@2 NA|NA|NA V ABC transporter, ATP-binding protein MAG.T12.14_02967 935866.JAER01000009_gene774 1.5e-170 606.3 Propionibacteriales fadD3 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 Bacteria 2GIXQ@201174,4DPPW@85009,COG1022@1,COG1022@2 NA|NA|NA I AMP-binding enzyme MAG.T12.14_02968 1122611.KB903944_gene1165 2e-08 65.9 Streptosporangiales Bacteria 2C5NN@1,2GV7Y@201174,2ZJPF@2,4EKGV@85012 NA|NA|NA MAG.T12.14_02969 1206732.BAGD01000097_gene4238 2.8e-32 145.6 Nocardiaceae Bacteria 2IMKC@201174,4G03M@85025,COG2021@1,COG2021@2 NA|NA|NA E Serine aminopeptidase, S33 MAG.T12.14_02971 1043493.BBLU01000002_gene1838 5.7e-31 141.4 Bacteria ko:K16129 ko01054,map01054 ko00000,ko00001,ko01008 Bacteria COG0500@1,COG2226@2 NA|NA|NA Q methyltransferase MAG.T12.14_02973 1169152.AXVD01000023_gene3257 4.9e-15 88.2 Nocardiaceae ydiN ko:K03762 ko00000,ko02000 2.A.1.6.4 Bacteria 2HHY4@201174,4G1MV@85025,COG0477@1,COG0477@2,COG0500@1,COG2226@2 NA|NA|NA Q Mycolic acid cyclopropane synthetase MAG.T12.14_02977 1306174.JODP01000013_gene7494 1.9e-32 144.8 Actinobacteria rpoZ GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 Bacteria 2IQHU@201174,COG1758@1,COG1758@2 NA|NA|NA K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits MAG.T12.14_02978 477641.MODMU_3312 4.9e-128 464.5 Frankiales coaBC GO:0003674,GO:0003824,GO:0004633,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016020,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJGJ@201174,4ERES@85013,COG0452@1,COG0452@2 NA|NA|NA H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine MAG.T12.14_02979 253839.SSNG_05645 7e-167 593.6 Actinobacteria metK GO:0003674,GO:0003824,GO:0004478,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0016740,GO:0016765,GO:0019899,GO:0030312,GO:0035375,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ4U@201174,COG0192@1,COG0192@2 NA|NA|NA H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme MAG.T12.14_02980 219305.MCAG_00089 5.3e-201 707.6 Micromonosporales ydaO Bacteria 2GK5V@201174,4DI99@85008,COG0531@1,COG0531@2 NA|NA|NA E Amino acid permease MAG.T12.14_02981 397278.JOJN01000010_gene2233 4.8e-08 65.5 Propionibacteriales Bacteria 2BXNT@1,2IIU0@201174,30VN0@2,4DQTR@85009 NA|NA|NA S Septum formation MAG.T12.14_02982 196162.Noca_0411 9.2e-14 84.0 Propionibacteriales Bacteria 2GMVK@201174,4DTD1@85009,COG4243@1,COG4243@2 NA|NA|NA S VKc MAG.T12.14_02983 110319.CF8_3936 4.9e-145 521.2 Propionibacteriales 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 Bacteria 2GIRF@201174,4DN8M@85009,COG2217@1,COG2217@2 NA|NA|NA P Heavy-metal-associated domain MAG.T12.14_02984 644283.Micau_2429 2.7e-98 365.5 Micromonosporales ko:K07483 ko00000 Bacteria 2GS79@201174,4D9V4@85008,COG3547@1,COG3547@2 NA|NA|NA L transposase IS116 IS110 IS902 family protein MAG.T12.14_02985 298655.KI912266_gene787 2.9e-120 438.7 Frankiales Bacteria 2GNQB@201174,4ETFP@85013,COG3547@1,COG3547@2 NA|NA|NA L transposase IS116 IS110 IS902 family protein MAG.T12.14_02987 1048339.KB913029_gene2728 9.7e-35 152.9 Frankiales nusG GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0030312,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 ko:K02601 ko00000,ko03009,ko03021 Bacteria 2GJFW@201174,4ES8J@85013,COG0250@1,COG0250@2 NA|NA|NA K Participates in transcription elongation, termination and antitermination MAG.T12.14_02988 1155718.KB891885_gene6434 1.3e-62 245.7 Actinobacteria rplK GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010467,GO:0015934,GO:0015968,GO:0016043,GO:0019538,GO:0019843,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0032984,GO:0032991,GO:0033554,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0042594,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0051716,GO:0065003,GO:0070925,GO:0071496,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02867 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IFCK@201174,COG0080@1,COG0080@2 NA|NA|NA J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors MAG.T12.14_02989 1089455.MOPEL_098_00060 1e-101 376.3 Dermatophilaceae rplA GO:0000027,GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006417,GO:0006446,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0017148,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045947,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 ko:K02863 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GM51@201174,4F6JF@85018,COG0081@1,COG0081@2 NA|NA|NA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release MAG.T12.14_02990 367299.JOEE01000001_gene2148 1.4e-60 239.6 Intrasporangiaceae rplJ GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0017148,GO:0019222,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 ko:K02864,ko:K02935 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GM0V@201174,4FEG8@85021,COG0244@1,COG0244@2 NA|NA|NA J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors MAG.T12.14_02991 446471.Xcel_3424 2.7e-17 95.1 Promicromonosporaceae Bacteria 2GRCJ@201174,4F5S5@85017,COG4961@1,COG4961@2 NA|NA|NA U TadE-like protein MAG.T12.14_02992 408672.NBCG_01573 6.7e-48 197.6 Propionibacteriales Bacteria 2DVVA@1,2IHH0@201174,32V07@2,4DRC3@85009 NA|NA|NA MAG.T12.14_02994 1380354.JIAN01000009_gene3757 2.9e-11 75.1 Bacteria Bacteria COG4961@1,COG4961@2 NA|NA|NA U PFAM TadE family protein MAG.T12.14_02998 1032480.MLP_34460 3.6e-50 205.7 Propionibacteriales Bacteria 28MCN@1,2GXXM@201174,2ZAQR@2,4DW15@85009 NA|NA|NA MAG.T12.14_02999 313589.JNB_18023 1.7e-138 499.2 Intrasporangiaceae wecB 5.1.3.14 ko:K01791 ko00520,ko01100,ko05111,map00520,map01100,map05111 M00362 R00420 RC00290 ko00000,ko00001,ko00002,ko01000,ko01005 Bacteria 2GJWS@201174,4FG1P@85021,COG0381@1,COG0381@2 NA|NA|NA M Belongs to the UDP-N-acetylglucosamine 2-epimerase family MAG.T12.14_03000 930171.Asphe3_25570 7.1e-08 62.0 Micrococcaceae fnlB 1.1.1.367 ko:K19068 ko00000,ko01000 Bacteria 1W83R@1268,2HJI9@201174,COG0451@1,COG0451@2,COG1898@1,COG1898@2 NA|NA|NA GM NAD dependent epimerase/dehydratase family MAG.T12.14_03001 358220.C380_09020 2e-195 688.3 Comamonadaceae pdeA Bacteria 1MU2C@1224,2VH3V@28216,4AA96@80864,COG5001@1,COG5001@2 NA|NA|NA T Diguanylate cyclase MAG.T12.14_03002 228405.HNE_2486 1.3e-119 436.0 Alphaproteobacteria tlpA Bacteria 1RC8N@1224,2U7IW@28211,COG0526@1,COG0526@2 NA|NA|NA CO COG0526, thiol-disulfide isomerase and thioredoxins MAG.T12.14_03003 1342299.Z947_1985 3.7e-31 140.6 Sulfitobacter Bacteria 1NCPQ@1224,2E6FA@1,2UKWD@28211,3312Q@2,3ZXTE@60136 NA|NA|NA MAG.T12.14_03004 861360.AARI_35960 2e-129 469.2 Micrococcaceae Bacteria 1W8U7@1268,2GJK7@201174,COG3464@1,COG3464@2 NA|NA|NA L 4.5 Transposon and IS MAG.T12.14_03005 1112204.GPOL_c26570 2.2e-13 80.9 Actinobacteria 2.1.1.72 ko:K00571,ko:K07316 ko00000,ko01000,ko02048 Bacteria 2I8FH@201174,COG2189@1,COG2189@2 NA|NA|NA L DNA methylase MAG.T12.14_03006 1120959.ATXF01000009_gene857 6.2e-42 176.4 Microbacteriaceae ko:K07483,ko:K07497 ko00000 Bacteria 2IMG6@201174,4FPFA@85023,COG2963@1,COG2963@2 NA|NA|NA L Transposase MAG.T12.14_03010 1476583.DEIPH_ctg017orf0093 1e-30 140.2 Deinococcus-Thermus Bacteria 1WKKZ@1297,COG2340@1,COG2340@2 NA|NA|NA S protein with SCP PR1 domains MAG.T12.14_03013 1123504.JQKD01000087_gene844 1.4e-17 95.1 Comamonadaceae Bacteria 1RJ6B@1224,2C06D@1,2VSUU@28216,32R6C@2,4AEU1@80864 NA|NA|NA MAG.T12.14_03014 159087.Daro_2227 7.9e-29 134.0 Betaproteobacteria Bacteria 1RD6N@1224,29QVI@1,2VR3I@28216,30BVQ@2 NA|NA|NA MAG.T12.14_03015 1132441.KI519454_gene683 7.7e-141 507.3 Micrococcaceae glnP ko:K02029,ko:K02030 M00236 ko00000,ko00002,ko02000 3.A.1.3 Bacteria 1W836@1268,2GJJ9@201174,COG0765@1,COG0765@2,COG0834@1,COG0834@2 NA|NA|NA P Bacterial extracellular solute-binding proteins, family 3 MAG.T12.14_03016 1001240.GY21_10825 3e-91 341.7 Microbacteriaceae glnQ 3.6.3.21 ko:K02028,ko:K10038 ko02010,map02010 M00227,M00236 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3,3.A.1.3.2 Bacteria 2GIZW@201174,4FKHI@85023,COG1126@1,COG1126@2 NA|NA|NA E ATPases associated with a variety of cellular activities MAG.T12.14_03017 1205910.B005_0853 3.1e-42 177.9 Streptosporangiales ko:K02029,ko:K10009 ko02010,map02010 M00234,M00236 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.10,3.A.1.3.14 Bacteria 2GJJ9@201174,4ENPH@85012,COG0765@1,COG0765@2 NA|NA|NA E Binding-protein-dependent transport system inner membrane component MAG.T12.14_03018 471852.Tcur_3681 1.1e-99 369.8 Streptosporangiales atrC 3.6.3.21 ko:K02028 M00236 ko00000,ko00002,ko01000,ko02000 3.A.1.3 Bacteria 2GIZW@201174,4EHV2@85012,COG1126@1,COG1126@2 NA|NA|NA E ATPases associated with a variety of cellular activities MAG.T12.14_03021 749414.SBI_08696 1.4e-69 269.6 Actinobacteria 3.2.1.10,3.2.1.20,3.2.1.93 ko:K01182,ko:K01187,ko:K01226 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00028,R00801,R00802,R00837,R01718,R01791,R06087,R06088,R06113,R06199 RC00028,RC00049,RC00059,RC00077,RC00451 ko00000,ko00001,ko01000 GH13,GH31 Bacteria 2GKS4@201174,COG0366@1,COG0366@2 NA|NA|NA G alpha amylase, catalytic MAG.T12.14_03022 35754.JNYJ01000043_gene4398 8.7e-20 105.1 Micromonosporales Bacteria 2GKG3@201174,4DDUZ@85008,COG2208@1,COG2208@2 NA|NA|NA KT Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) MAG.T12.14_03028 1089455.MOPEL_010_00010 4.9e-185 654.1 Dermatophilaceae Bacteria 2H68X@201174,4F7DH@85018,COG3385@1,COG3385@2 NA|NA|NA L Transposase DDE domain group 1 MAG.T12.14_03031 1273125.Rrhod_2717 5.7e-37 161.8 Nocardiaceae pflA ko:K15539 ko00000 Bacteria 2GNIS@201174,4FVJA@85025,COG2976@1,COG2976@2 NA|NA|NA S Protein of unknown function (DUF4012) MAG.T12.14_03033 1210045.ALNP01000009_gene4681 1.2e-12 81.6 Actinobacteria moxJ ko:K02030,ko:K02424,ko:K16254 ko00680,ko01120,ko02010,map00680,map01120,map02010 M00234,M00236 ko00000,ko00001,ko00002,ko02000,ko02035 3.A.1.3,3.A.1.3.10,3.A.1.3.14 Bacteria 2GIV0@201174,COG0515@1,COG0515@2,COG0834@1,COG0834@2 NA|NA|NA KLT serine threonine protein kinase MAG.T12.14_03036 1906.SFRA_22065 2.4e-46 192.2 Bacteria Bacteria COG1309@1,COG1309@2 NA|NA|NA K transcriptional regulator MAG.T12.14_03039 1288083.AUKR01000055_gene224 1.7e-51 209.1 Actinobacteria Bacteria 2B34Q@1,2I2K1@201174,2ZK49@2 NA|NA|NA MAG.T12.14_03040 222534.KB893794_gene2458 1.4e-66 259.2 Frankiales ilvN GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0030312,GO:0032991,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 iECO103_1326.ilvN,iJN678.ilvN Bacteria 2GJCH@201174,4ESEU@85013,COG0440@1,COG0440@2 NA|NA|NA E Acetolactate synthase, small subunit MAG.T12.14_03041 1122611.KB903963_gene4707 1.1e-28 132.1 Streptosporangiales ilvB 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKU4@201174,4EG2X@85012,COG0028@1,COG0028@2 NA|NA|NA EH Thiamine pyrophosphate enzyme, central domain MAG.T12.14_03042 1286631.X805_04260 7e-37 159.5 unclassified Burkholderiales pstB 3.6.3.27 ko:K02036 ko02010,map02010 M00222 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 Bacteria 1KK41@119065,1MU16@1224,2VI4J@28216,COG1117@1,COG1117@2 NA|NA|NA P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system MAG.T12.14_03043 987059.RBXJA2T_09727 1.8e-93 349.0 unclassified Burkholderiales phoU GO:0000287,GO:0001558,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006873,GO:0006950,GO:0007154,GO:0008150,GO:0009266,GO:0009267,GO:0009268,GO:0009405,GO:0009408,GO:0009605,GO:0009628,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010563,GO:0010605,GO:0010629,GO:0010966,GO:0016020,GO:0016036,GO:0019220,GO:0019222,GO:0019725,GO:0019897,GO:0019898,GO:0022898,GO:0030002,GO:0030145,GO:0030320,GO:0030643,GO:0031323,GO:0031324,GO:0031667,GO:0031668,GO:0031669,GO:0032409,GO:0032410,GO:0032412,GO:0032413,GO:0032879,GO:0033554,GO:0034605,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0040008,GO:0042221,GO:0042592,GO:0042594,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043269,GO:0043271,GO:0044070,GO:0044092,GO:0044419,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045936,GO:0046677,GO:0046872,GO:0046914,GO:0046983,GO:0048519,GO:0048523,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051049,GO:0051051,GO:0051128,GO:0051174,GO:0051704,GO:0051716,GO:0055062,GO:0055081,GO:0055082,GO:0055083,GO:0060255,GO:0065007,GO:0065008,GO:0065009,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071496,GO:0071944,GO:0072501,GO:0072502,GO:0072505,GO:0072506,GO:0098771,GO:0104004,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 ko:K02039 ko00000 Bacteria 1KIW3@119065,1MUMI@1224,2VI2C@28216,COG0704@1,COG0704@2 NA|NA|NA P Plays a role in the regulation of phosphate uptake MAG.T12.14_03045 882082.SaccyDRAFT_4947 3.4e-22 111.3 Pseudonocardiales Bacteria 2BQZA@1,2H855@201174,32JWM@2,4ECHQ@85010 NA|NA|NA MAG.T12.14_03047 1146883.BLASA_1786 1.8e-208 731.9 Frankiales Bacteria 2GJK7@201174,4ES3E@85013,COG3464@1,COG3464@2 NA|NA|NA L PFAM transposase IS204 IS1001 IS1096 IS1165 family protein MAG.T12.14_03048 67352.JODS01000014_gene5359 4.1e-180 637.5 Actinobacteria uvrA GO:0000018,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045910,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0071944,GO:0080090 ko:K03701 ko03420,map03420 ko00000,ko00001,ko03400 Bacteria 2GJUV@201174,COG0178@1,COG0178@2 NA|NA|NA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate MAG.T12.14_03051 1417296.U879_02935 1.3e-154 552.7 Alphaproteobacteria purK GO:0000166,GO:0003674,GO:0003824,GO:0004638,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016829,GO:0016830,GO:0016831,GO:0016874,GO:0016879,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034028,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.4.18 ko:K01589 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07404 RC01927 ko00000,ko00001,ko00002,ko01000 iECUMN_1333.ECUMN_0562,iYL1228.KPN_00477 Bacteria 1MU70@1224,2TRSV@28211,COG0026@1,COG0026@2 NA|NA|NA F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) MAG.T12.14_03052 1386089.N865_03210 4.8e-114 417.5 Actinobacteria ko:K07487 ko00000 Bacteria 2HW75@201174,COG3039@1,COG3039@2,COG3547@1,COG3547@2 NA|NA|NA L PFAM transposase, IS4 family protein MAG.T12.14_03053 110662.Syncc9605_1272 4.9e-11 73.9 Synechococcus Bacteria 1GNNN@1117,1H18P@1129,2A4EJ@1,30T0D@2 NA|NA|NA MAG.T12.14_03055 487521.OCU_01750 2e-29 134.8 Mycobacteriaceae gltB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016020,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 Bacteria 2343P@1762,2GN09@201174,COG0067@1,COG0067@2,COG0069@1,COG0069@2,COG0070@1,COG0070@2 NA|NA|NA E glutamate synthase MAG.T12.14_03057 1239962.C943_03079 3.6e-117 427.6 Cytophagia Bacteria 2BB8B@1,324R0@2,47RS3@768503,4NQG8@976 NA|NA|NA MAG.T12.14_03058 1239962.C943_03080 8.6e-24 115.5 Cytophagia mdlA ko:K06147,ko:K18889 ko02010,map02010 M00707 ko00000,ko00001,ko00002,ko02000 3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21 Bacteria 47JPX@768503,4NDY6@976,COG1132@1,COG1132@2 NA|NA|NA V ABC transporter transmembrane region MAG.T12.14_03059 47716.JOFH01000021_gene4179 2.4e-15 88.6 Actinobacteria 2.7.11.1 ko:K04757 ko00000,ko01000,ko01001,ko03021 Bacteria 2IHNR@201174,COG2172@1,COG2172@2 NA|NA|NA T anti-sigma regulatory factor MAG.T12.14_03060 298653.Franean1_0312 4.5e-23 114.0 Frankiales rsbV GO:0003674,GO:0005488,GO:0005515,GO:0042802 ko:K04749 ko00000,ko03021 Bacteria 2IHQG@201174,4ESTZ@85013,COG1366@1,COG1366@2 NA|NA|NA T Belongs to the anti-sigma-factor antagonist family MAG.T12.14_03061 469383.Cwoe_1507 8.2e-30 137.1 Rubrobacteria ko:K03088 ko00000,ko03021 Bacteria 2IRNG@201174,4CTBE@84995,COG1595@1,COG1595@2 NA|NA|NA K Sigma-70 region 2 MAG.T12.14_03062 1463841.JOIR01000023_gene507 3.5e-42 178.7 Actinobacteria 3.2.2.21 ko:K01247 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 2GP69@201174,COG0122@1,COG0122@2 NA|NA|NA L 3-methyladenine DNA glycosylase MAG.T12.14_03063 477641.MODMU_4109 8.8e-25 120.6 Frankiales ligA GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 2.7.7.7,6.5.1.2 ko:K01972,ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03430,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03430,map03440 M00260 R00375,R00376,R00377,R00378,R00382 RC00005,RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 2GJZ0@201174,4EWD5@85013,COG0272@1,COG0272@2,COG0847@1,COG0847@2 NA|NA|NA L EXOIII MAG.T12.14_03064 987059.RBXJA2T_09377 7e-22 109.8 unclassified Burkholderiales ppx 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 R03409 RC00002 ko00000,ko00001,ko01000 Bacteria 1KJF7@119065,1MV35@1224,2VI1K@28216,COG0248@1,COG0248@2 NA|NA|NA FP PFAM Ppx GppA phosphatase MAG.T12.14_03065 1440774.Y900_021210 1.5e-19 101.7 Mycobacteriaceae Bacteria 23BC4@1762,2EUTX@1,2GRIM@201174,33N9F@2 NA|NA|NA S Protein of unknown function (DUF3618) MAG.T12.14_03067 1150398.JIBJ01000004_gene2893 1.2e-13 82.8 Micrococcaceae mihF 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 1W9UW@1268,2IKPU@201174,COG0099@1,COG0099@2 NA|NA|NA J integration host factor MAG.T12.14_03069 1122609.AUGT01000005_gene1828 1.1e-14 86.7 Actinobacteria Bacteria 2BIFQ@1,2IN70@201174,32CNA@2 NA|NA|NA # 2614 queries scanned # Total time (seconds): 53.777107954 # Rate: 48.61 q/s