# emapper version: emapper-2.0.1 emapper DB: 2.0 # command: ./emapper.py -m diamond --seed_ortholog_evalue 0.00001 --data_dir /home/bayegy/Databases/emapper/data_dir2.0.1/ --cpu 45 --temp_dir /media/bayegy/disk0/binning_test/Bin_all/emapper//bin.T13.23/_tmp -i /media/bayegy/disk0/binning_test/Bin_all/Bin_prokka//bin.T13.23/bin.T13.23.faa -o /media/bayegy/disk0/binning_test/Bin_all/emapper//bin.T13.23/bin.T13.23 --usemem --override # time: Wed Nov 3 15:49:22 2021 #query_name seed_eggNOG_ortholog seed_ortholog_evalue seed_ortholog_score best_tax_level Preferred_name GOs EC KEGG_ko KEGG_Pathway KEGG_Module KEGG_Reaction KEGG_rclass BRITE KEGG_TC CAZy BiGG_Reaction taxonomic scope eggNOG OGs best eggNOG OG COG Functional cat. eggNOG free text desc. KOPIJCMJ_00002 1394178.AWOO02000006_gene3482 3.9e-143 515.0 Streptosporangiales traD ko:K12071 ko00000,ko02044 3.A.7.11.1 Bacteria 2I70J@201174,4EN6Y@85012,COG0433@1,COG0433@2 NA|NA|NA S COG0433 Predicted ATPase KOPIJCMJ_00003 2074.JNYD01000006_gene1826 5.3e-10 69.7 Pseudonocardiales Bacteria 28IPW@1,2HQJM@201174,2Z8PQ@2,4E9H1@85010 NA|NA|NA KOPIJCMJ_00005 1394178.AWOO02000005_gene3524 2.1e-111 409.1 Streptosporangiales exoA Bacteria 2GMWF@201174,4EHSA@85012,COG1215@1,COG1215@2 NA|NA|NA M Glycosyl transferase family 21 KOPIJCMJ_00007 1449347.JQLN01000007_gene1076 7.6e-138 497.3 Kitasatospora ypeA ko:K13525 ko04141,ko05134,map04141,map05134 M00400,M00403 ko00000,ko00001,ko00002,ko03019,ko04131,ko04147 3.A.16.1 Bacteria 2GJ07@201174,2M4MQ@2063,COG0454@1,COG0456@2,COG0464@1,COG0464@2 NA|NA|NA KO ATPase family associated with various cellular activities (AAA) KOPIJCMJ_00008 1298863.AUEP01000003_gene2815 1e-258 899.4 Propionibacteriales flhA GO:0005575,GO:0005623,GO:0005886,GO:0006996,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0022607,GO:0030030,GO:0030031,GO:0044085,GO:0044464,GO:0044780,GO:0044781,GO:0070925,GO:0071840,GO:0071944 ko:K02400 ko02040,map02040 ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 Bacteria 2IB5S@201174,4DP8V@85009,COG1298@1,COG1298@2 NA|NA|NA NU Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin KOPIJCMJ_00010 1283287.KB822581_gene1520 9.2e-23 112.5 Propionibacteriales csrA ko:K03563,ko:K13626 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 ko00000,ko00001,ko02035,ko03019 Bacteria 2GRPH@201174,4DS3Q@85009,COG1551@1,COG1551@2 NA|NA|NA T Global regulator protein family KOPIJCMJ_00011 1298863.AUEP01000003_gene2847 4.4e-36 157.5 Propionibacteriales fliW ko:K13626 ko00000,ko02035 Bacteria 2GT61@201174,4DRPC@85009,COG1699@1,COG1699@2 NA|NA|NA S Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum KOPIJCMJ_00012 196162.Noca_0770 6.9e-79 300.8 Propionibacteriales flgL GO:0005575,GO:0005576,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464 ko:K02397 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 2IA40@201174,4DNBS@85009,COG1344@1,COG1344@2 NA|NA|NA N Bacterial flagellin C-terminal helical region KOPIJCMJ_00013 935866.JAER01000071_gene1362 4.8e-127 461.5 Propionibacteriales flgK ko:K02396 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 2GNXQ@201174,4DNRW@85009,COG1256@1,COG1256@2 NA|NA|NA N Flagellar basal body rod FlgEFG protein C-terminal KOPIJCMJ_00014 1298863.AUEP01000003_gene2844 2.8e-42 178.3 Propionibacteriales flgN Bacteria 2B12R@1,2IQ5J@201174,31TG8@2,4DRX1@85009 NA|NA|NA S FlgN protein KOPIJCMJ_00016 1035308.AQYY01000001_gene2568 7.4e-264 916.4 Peptococcaceae glgB GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901576 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 ko00000,ko00001,ko00002,ko01000,ko04147 CBM48,GH13 Bacteria 1TP4M@1239,247WH@186801,260UV@186807,COG0296@1,COG0296@2 NA|NA|NA G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position KOPIJCMJ_00017 649831.L083_4309 4.6e-33 147.9 Micromonosporales Bacteria 2IK2E@201174,4DIYC@85008,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family KOPIJCMJ_00019 405948.SACE_4580 1.2e-27 131.0 Pseudonocardiales yhgE ko:K01421 ko00000 Bacteria 2GKEM@201174,4E1UI@85010,COG1511@1,COG1511@2 NA|NA|NA S YhgE Pip domain protein KOPIJCMJ_00020 1304865.JAGF01000001_gene125 3.5e-133 481.9 Actinobacteria Bacteria 2IA73@201174,COG1085@1,COG1085@2 NA|NA|NA C uridylyltransferase KOPIJCMJ_00021 153721.MYP_828 6.3e-51 208.8 Bacteria Bacteria 2EPPK@1,33HA5@2 NA|NA|NA KOPIJCMJ_00022 1043205.AFYF01000026_gene433 0.0 1241.1 Intrasporangiaceae helZ 2.7.11.1 ko:K08282 ko00000,ko01000 Bacteria 2GISC@201174,4FFBR@85021,COG0553@1,COG0553@2,COG4715@1,COG4715@2 NA|NA|NA L SNF2 family N-terminal domain KOPIJCMJ_00023 2045.KR76_01175 1e-31 143.7 Propionibacteriales Bacteria 2I8Y7@201174,4DU0I@85009,COG2197@1,COG2197@2 NA|NA|NA KT Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain KOPIJCMJ_00025 909613.UO65_1997 2.6e-65 255.0 Pseudonocardiales ybhB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 ko:K06910 ko00000 Bacteria 2GMIG@201174,4DYXA@85010,COG1881@1,COG1881@2 NA|NA|NA S TIGRFAM Raf kinase inhibitor-like protein, YbhB YbcL family KOPIJCMJ_00026 765910.MARPU_00780 1.3e-104 386.7 Chromatiales gdh 1.4.1.4 ko:K00262 ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100 R00248 RC00006,RC02799 ko00000,ko00001,ko01000 Bacteria 1NPPY@1224,1RRKZ@1236,1WWQA@135613,COG4198@1,COG4198@2 NA|NA|NA S Protein of unknown function (DUF1015) KOPIJCMJ_00027 1192034.CAP_2687 8.8e-61 240.7 Myxococcales 2.7.1.15,2.7.1.187,2.7.1.45 ko:K00852,ko:K00874,ko:K19978 ko00030,ko00525,ko01100,ko01120,ko01130,ko01200,map00030,map00525,map01100,map01120,map01130,map01200 M00061,M00308,M00631 R01051,R01541,R02750,R11184 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 1RBE0@1224,2X9ZP@28221,2YVZZ@29,4386N@68525,COG0524@1,COG0524@2 NA|NA|NA G pfkB family carbohydrate kinase KOPIJCMJ_00028 397278.JOJN01000011_gene1599 2.5e-84 319.3 Propionibacteriales Bacteria 2GJM3@201174,4DNDV@85009,COG1316@1,COG1316@2 NA|NA|NA K Cell envelope-related transcriptional attenuator domain KOPIJCMJ_00029 1313172.YM304_27660 6.9e-214 750.7 Bacteria Bacteria COG0433@1,COG0433@2 NA|NA|NA S helicase activity KOPIJCMJ_00030 1123023.JIAI01000002_gene4736 1.6e-163 582.4 Pseudonocardiales rocD GO:0003674,GO:0003824,GO:0004587,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016740,GO:0016769,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.6.1.11,2.6.1.13,2.6.1.17 ko:K00819,ko:K00821 ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R00667,R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 iYO844.BSU40340 Bacteria 2GK0J@201174,4DZYH@85010,COG4992@1,COG4992@2 NA|NA|NA E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family KOPIJCMJ_00031 367299.JOEE01000002_gene2367 4.8e-60 238.8 Intrasporangiaceae dacB 3.4.16.4 ko:K07259 ko00550,map00550 ko00000,ko00001,ko01000,ko01002,ko01011 Bacteria 2GJPH@201174,4FGTP@85021,COG2027@1,COG2027@2 NA|NA|NA M D-Ala-D-Ala carboxypeptidase 3 (S13) family KOPIJCMJ_00032 446471.Xcel_1105 2.1e-55 221.9 Promicromonosporaceae rpiB 5.3.1.6 ko:K01808 ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKJG@201174,4F4DS@85017,COG0698@1,COG0698@2 NA|NA|NA G Ribose/Galactose Isomerase KOPIJCMJ_00033 1033730.CAHG01000015_gene774 3.8e-66 258.5 Propionibacteriales pepN 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 Bacteria 2GJJ4@201174,4DNEA@85009,COG0308@1,COG0308@2 NA|NA|NA E ERAP1-like C-terminal domain KOPIJCMJ_00034 1306174.JODP01000013_gene7450 4.5e-132 478.0 Bacteria ko:K01999 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria COG0683@1,COG0683@2 NA|NA|NA E ABC-type branched-chain amino acid transport systems, periplasmic component KOPIJCMJ_00035 1306174.JODP01000013_gene7455 3.1e-102 378.6 Actinobacteria ko:K01997 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 2GMAY@201174,COG0559@1,COG0559@2 NA|NA|NA E Belongs to the binding-protein-dependent transport system permease family KOPIJCMJ_00036 298654.FraEuI1c_4843 2.7e-177 628.6 Frankiales gcs2 Bacteria 2GN0J@201174,4ES9X@85013,COG2308@1,COG2308@2 NA|NA|NA S Circularly permuted ATP-grasp type 2 KOPIJCMJ_00037 397278.JOJN01000019_gene2352 1.1e-44 187.2 Propionibacteriales MA20_32425 Bacteria 2GN0T@201174,4DP16@85009,COG2307@1,COG2307@2 NA|NA|NA S A predicted alpha-helical domain with a conserved ER motif. KOPIJCMJ_00038 1283283.ATXA01000013_gene3448 1.7e-66 259.6 Frankiales Bacteria 2GN5D@201174,4ESH4@85013,COG1305@1,COG1305@2 NA|NA|NA E Bacterial transglutaminase-like N-terminal region KOPIJCMJ_00039 1229780.BN381_130301 6.6e-50 204.1 unclassified Actinobacteria (class) plsC2 Bacteria 2IDC7@201174,3UXB2@52018,COG0204@1,COG0204@2 NA|NA|NA I Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology KOPIJCMJ_00041 102129.Lepto7375DRAFT_2915 1e-54 219.9 Oscillatoriales apt 2.4.2.7 ko:K00759 ko00230,ko01100,map00230,map01100 R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko04147 Bacteria 1G508@1117,1HAKH@1150,COG0503@1,COG0503@2 NA|NA|NA F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis KOPIJCMJ_00042 1043493.BBLU01000006_gene2218 3.1e-56 225.7 Actinobacteria Bacteria 2I8IC@201174,COG2334@1,COG2334@2 NA|NA|NA EGP Major facilitator Superfamily KOPIJCMJ_00043 309800.C498_16184 4.8e-40 171.4 Halobacteria Archaea 23WKG@183963,2XXWE@28890,arCOG13341@1,arCOG13341@2157 NA|NA|NA KOPIJCMJ_00044 1504319.GM45_0280 4.1e-71 274.6 unclassified Actinobacteria (class) yhhQ ko:K09125 ko00000 Bacteria 2IFDB@201174,3UX0S@52018,COG1738@1,COG1738@2 NA|NA|NA U Involved in the import of queuosine (Q) precursors, required for Q precursor salvage KOPIJCMJ_00045 479431.Namu_3445 4.5e-69 268.1 Actinobacteria 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 Bacteria 2GW7W@201174,COG3001@1,COG3001@2 NA|NA|NA G Fructosamine kinase KOPIJCMJ_00046 1121933.AUHH01000015_gene423 6.6e-41 174.1 Propionibacteriales tgt 2.4.2.29 ko:K00773 R03789,R10209 RC00063 ko00000,ko01000,ko03016 Bacteria 2GMWY@201174,4DU0Z@85009,COG0343@1,COG0343@2 NA|NA|NA J Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) KOPIJCMJ_00049 326424.FRAAL4415 9.9e-56 223.8 Actinobacteria Bacteria 2GIV0@201174,COG0515@1,COG0515@2 NA|NA|NA KLT serine threonine protein kinase KOPIJCMJ_00050 644283.Micau_2859 1e-188 666.4 Micromonosporales ko:K01436 ko00000,ko01000,ko01002 Bacteria 2I2WA@201174,4DBB4@85008,COG1473@1,COG1473@2 NA|NA|NA S amidohydrolase KOPIJCMJ_00051 477641.MODMU_2141 5.8e-48 198.0 Frankiales yybG Bacteria 2GM3W@201174,4EUFF@85013,COG1357@1,COG1357@2 NA|NA|NA S Pentapeptide repeats (8 copies) KOPIJCMJ_00052 28444.JODQ01000007_gene5583 1.1e-36 160.2 Streptosporangiales chpE ko:K06600,ko:K06895 ko00000,ko02000,ko02035 2.A.75.1,2.A.76 Bacteria 2INXA@201174,4EPSU@85012,COG1280@1,COG1280@2 NA|NA|NA E LysE type translocator KOPIJCMJ_00053 1206101.AZXC01000010_gene23 5.1e-83 314.7 Actinobacteria Bacteria 2GIS3@201174,COG0604@1,COG0604@2 NA|NA|NA C alcohol dehydrogenase KOPIJCMJ_00054 1108045.GORHZ_150_00010 1.4e-49 203.0 Actinobacteria Bacteria 2IMPX@201174,2ZF5I@2,arCOG07533@1 NA|NA|NA S Domain of unknown function (DUF4386) KOPIJCMJ_00055 1304865.JAGF01000001_gene923 1.3e-34 152.9 Cellulomonadaceae galE1 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 Bacteria 2GMCW@201174,4F0IT@85016,COG1087@1,COG1087@2 NA|NA|NA M Belongs to the NAD(P)-dependent epimerase dehydratase family KOPIJCMJ_00056 1137271.AZUM01000002_gene3043 1.5e-175 623.2 Pseudonocardiales ko:K06994 ko00000 Bacteria 2GIRQ@201174,4DZH4@85010,COG2409@1,COG2409@2 NA|NA|NA S RND superfamily KOPIJCMJ_00057 1155718.KB891877_gene5380 1e-30 139.0 Actinobacteria Bacteria 2GKDR@201174,COG0523@1,COG0523@2 NA|NA|NA S cobalamin synthesis CobW domain protein KOPIJCMJ_00058 526225.Gobs_1602 3.8e-61 241.9 Frankiales scbA ko:K09815 ko02010,map02010 M00242 ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 Bacteria 2GM1K@201174,4ET8X@85013,COG0803@1,COG0803@2 NA|NA|NA P Belongs to the bacterial solute-binding protein 9 family KOPIJCMJ_00059 405948.SACE_1498 6e-31 140.6 Pseudonocardiales zur GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010043,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0046872,GO:0046914,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 ko:K02076,ko:K03711,ko:K09823 ko02024,map02024 ko00000,ko00001,ko03000 Bacteria 2IKS3@201174,4E2M3@85010,COG0735@1,COG0735@2 NA|NA|NA P Belongs to the Fur family KOPIJCMJ_00060 590998.Celf_3120 1.6e-78 300.1 Cellulomonadaceae Bacteria 2HNN0@201174,4F0DD@85016,COG0523@1,COG0523@2 NA|NA|NA S PFAM cobalamin synthesis CobW domain protein KOPIJCMJ_00061 675635.Psed_6174 2.7e-169 601.7 Pseudonocardiales fadI GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0003988,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005777,GO:0005782,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0031907,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0032787,GO:0034440,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0055114,GO:0070013,GO:0071704,GO:0072329,GO:0097159,GO:1901363,GO:1901575 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GJI8@201174,4DXSK@85010,COG0183@1,COG0183@2 NA|NA|NA I Belongs to the thiolase family KOPIJCMJ_00065 935866.JAER01000071_gene1360 1.2e-91 343.2 Propionibacteriales fliA 2.7.11.1 ko:K02405,ko:K12132 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 ko00000,ko00001,ko01000,ko01001,ko02035,ko03021 Bacteria 2GKBK@201174,4DP9I@85009,COG1191@1,COG1191@2 NA|NA|NA K RNA polymerase, sigma 28 subunit, SigD FliA WhiG KOPIJCMJ_00066 935866.JAER01000069_gene1411 5.7e-109 400.6 Propionibacteriales fliC ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 ko00000,ko00001,ko02035 Bacteria 2GUKT@201174,4DP5T@85009,COG1344@1,COG1344@2 NA|NA|NA N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella KOPIJCMJ_00067 1298863.AUEP01000003_gene2841 1.4e-91 343.6 Propionibacteriales fliD GO:0001539,GO:0003674,GO:0005198,GO:0005575,GO:0005576,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009420,GO:0009421,GO:0009424,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588 ko:K02407 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 2IBVB@201174,4DP7F@85009,COG1345@1,COG1345@2 NA|NA|NA N Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end KOPIJCMJ_00068 526225.Gobs_0983 7.6e-27 126.7 Frankiales fliS GO:0001539,GO:0003674,GO:0005198,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588 ko:K02422 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 2IRX7@201174,4ET7K@85013,COG1516@1,COG1516@2 NA|NA|NA N flagellar protein FliS KOPIJCMJ_00070 196162.Noca_0762 7.2e-27 126.7 Propionibacteriales flgB ko:K02387 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 2IQWB@201174,4DUZX@85009,COG1815@1,COG1815@2 NA|NA|NA N Flagella basal body rod protein KOPIJCMJ_00071 1298863.AUEP01000003_gene2837 4.8e-40 170.6 Propionibacteriales flgC GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009425,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588 ko:K02388 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 2IKRZ@201174,4DR9V@85009,COG1558@1,COG1558@2 NA|NA|NA N Flagellar basal body rod FlgEFG protein C-terminal KOPIJCMJ_00072 196162.Noca_0760 1.2e-23 115.9 Propionibacteriales fliE GO:0005575,GO:0005623,GO:0009288,GO:0009425,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464 ko:K02408 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 2GR0F@201174,4DSFF@85009,COG1677@1,COG1677@2 NA|NA|NA NU Flagellar hook-basal body complex protein FliE KOPIJCMJ_00073 196162.Noca_0759 1.4e-135 490.0 Propionibacteriales fliF ko:K02409 ko02040,map02040 ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 Bacteria 2HG9F@201174,4DP5G@85009,COG1766@1,COG1766@2 NA|NA|NA NU Flagellar M-ring protein C-terminal KOPIJCMJ_00074 1283287.KB822581_gene1476 9.8e-117 426.8 Propionibacteriales fliG GO:0001539,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006928,GO:0006935,GO:0006996,GO:0008150,GO:0009288,GO:0009425,GO:0009605,GO:0009987,GO:0016020,GO:0016043,GO:0022607,GO:0030030,GO:0030031,GO:0040011,GO:0042221,GO:0042330,GO:0042802,GO:0042803,GO:0042995,GO:0043226,GO:0043228,GO:0044085,GO:0044403,GO:0044419,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0044780,GO:0044781,GO:0046982,GO:0046983,GO:0048870,GO:0050896,GO:0051179,GO:0051674,GO:0051701,GO:0051704,GO:0052116,GO:0052126,GO:0052127,GO:0052143,GO:0052192,GO:0052195,GO:0052216,GO:0052243,GO:0070925,GO:0071840,GO:0071944,GO:0071973,GO:0071978,GO:0097588 ko:K02410 ko02030,ko02040,map02030,map02040 ko00000,ko00001,ko02035 Bacteria 2GP1H@201174,4DP5X@85009,COG1536@1,COG1536@2 NA|NA|NA N FliG N-terminal domain KOPIJCMJ_00075 1089553.Tph_c23820 2.8e-137 495.7 Thermoanaerobacterales Bacteria 1TPAA@1239,2492T@186801,42FY1@68295,COG5421@1,COG5421@2 NA|NA|NA L Best Blastp hit gi 4323609 gb AAD16446.1 (AF101410) transposase Mycoplasma mycoides subsp. mycoides SC gi 4323611 gb AAD16447.1 (AF101411) transposase Mycoplasma mycoides subsp. mycoides SC gi 4323613 gb AAD16448.1 (AF101412) transposase Mycoplasma mycoides subsp. mycoides SC , score KOPIJCMJ_00076 105420.BBPO01000125_gene4715 2.9e-15 87.8 Streptacidiphilus Bacteria 2BVHC@1,2IN31@201174,2NMD9@228398,32QVY@2 NA|NA|NA KOPIJCMJ_00077 1380356.JNIK01000018_gene821 5.3e-33 148.7 Frankiales Bacteria 2ICMJ@201174,4ETKK@85013,COG0392@1,COG0392@2 NA|NA|NA S Lysylphosphatidylglycerol synthase TM region KOPIJCMJ_00078 446471.Xcel_1165 3.4e-185 654.8 Promicromonosporaceae ffh GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006605,GO:0006612,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0030312,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0040007,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046907,GO:0048500,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0071944,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1990904 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 Bacteria 2GK4R@201174,4F37P@85017,COG0541@1,COG0541@2 NA|NA|NA U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY KOPIJCMJ_00079 1464048.JNZS01000025_gene780 1.6e-118 433.0 Micromonosporales ycaQ ko:K09927 ko00000 Bacteria 2GJM7@201174,4DA91@85008,COG3214@1,COG3214@2 NA|NA|NA S Winged helix DNA-binding domain KOPIJCMJ_00080 561175.KB894094_gene1857 1.1e-45 189.5 Streptosporangiales rpsP GO:0000028,GO:0000217,GO:0000400,GO:0003674,GO:0003676,GO:0003677,GO:0003735,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006259,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016787,GO:0016788,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02959 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011,ko03029 Bacteria 2IKU0@201174,4EJRE@85012,COG0228@1,COG0228@2 NA|NA|NA J Ribosomal protein S16 KOPIJCMJ_00081 1274.HX89_09660 2e-21 108.2 Dermacoccaceae CP_0960 GO:0008150,GO:0040007 ko:K06960 ko00000 Bacteria 1ZW6W@145357,2IQ4C@201174,COG1837@1,COG1837@2 NA|NA|NA S KH domain KOPIJCMJ_00082 479433.Caci_1514 7.6e-38 163.7 Actinobacteria rimM GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 ko:K02860 ko00000,ko03009 Bacteria 2GK4I@201174,COG0806@1,COG0806@2 NA|NA|NA J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes KOPIJCMJ_00083 471852.Tcur_3420 2.8e-81 308.5 Streptosporangiales trmD GO:0000287,GO:0001510,GO:0002939,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050518,GO:0052906,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228,4.6.1.12 ko:K00554,ko:K01770 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R00597,R05637 RC00002,RC00003,RC00334,RC01440 ko00000,ko00001,ko00002,ko01000,ko03016 Bacteria 2GJ1G@201174,4EGB1@85012,COG0336@1,COG0336@2 NA|NA|NA J Belongs to the RNA methyltransferase TrmD family KOPIJCMJ_00084 477641.MODMU_4415 1.2e-50 205.7 Frankiales rplS GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02884 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IHRT@201174,4ESVQ@85013,COG0335@1,COG0335@2 NA|NA|NA J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site KOPIJCMJ_00085 1203568.HMPREF1484_00113 2.8e-33 148.7 Dermabacteraceae 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 ko00000,ko00001,ko01000,ko01002 Bacteria 2GIYN@201174,4FCW9@85020,COG0681@1,COG0681@2 NA|NA|NA U Signal peptidase, peptidase S26 KOPIJCMJ_00086 1155718.KB891909_gene1213 2.4e-54 218.8 Actinobacteria lepB GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 ko00000,ko00001,ko01000,ko01002 Bacteria 2GIYN@201174,COG0681@1,COG0681@2 NA|NA|NA U Belongs to the peptidase S26 family KOPIJCMJ_00087 1304865.JAGF01000001_gene3835 9.6e-66 256.9 Cellulomonadaceae rnhB GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 ko:K03470 ko03030,map03030 ko00000,ko00001,ko01000,ko03032 Bacteria 2GJFN@201174,4F15R@85016,COG0164@1,COG0164@2 NA|NA|NA L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids KOPIJCMJ_00088 1120950.KB892769_gene5382 1.9e-27 128.6 Propionibacteriales yraN ko:K07460 ko00000 Bacteria 2IQ3X@201174,4DRQN@85009,COG0792@1,COG0792@2 NA|NA|NA L Belongs to the UPF0102 family KOPIJCMJ_00089 1043493.BBLU01000010_gene217 1.2e-121 443.7 Actinobacteria ko:K07391 ko00000 Bacteria 2GJIQ@201174,COG0606@1,COG0606@2 NA|NA|NA O PFAM magnesium chelatase ChlI subunit KOPIJCMJ_00090 1386089.N865_10205 5.4e-78 298.1 Intrasporangiaceae dprA 5.99.1.2 ko:K03168,ko:K04096 ko00000,ko01000,ko03032,ko03400 Bacteria 2GKDA@201174,4FEJX@85021,COG0758@1,COG0758@2 NA|NA|NA LU Rossmann fold nucleotide-binding protein involved in DNA uptake KOPIJCMJ_00091 397278.JOJN01000001_gene2687 3.3e-92 345.1 Propionibacteriales xerC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03733,ko:K04763 ko00000,ko03036 Bacteria 2GNDP@201174,4DN7T@85009,COG4974@1,COG4974@2 NA|NA|NA L Belongs to the 'phage' integrase family. XerC subfamily KOPIJCMJ_00092 351607.Acel_1546 3.7e-93 348.2 Frankiales sigD ko:K02405 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 ko00000,ko00001,ko02035,ko03021 Bacteria 2GKBK@201174,4ERYG@85013,COG1191@1,COG1191@2 NA|NA|NA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released KOPIJCMJ_00093 570268.ANBB01000022_gene5213 8.9e-31 140.6 Streptosporangiales Bacteria 2IQ64@201174,4EJY5@85012,COG0739@1,COG0739@2 NA|NA|NA M Peptidase family M23 KOPIJCMJ_00094 1123322.KB904679_gene3221 3.6e-115 421.4 Actinobacteria rpsB GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02967 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GMYC@201174,COG0052@1,COG0052@2 NA|NA|NA J Belongs to the universal ribosomal protein uS2 family KOPIJCMJ_00095 446462.Amir_5910 1e-84 320.1 Pseudonocardiales tsf GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0030312,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02357 ko00000,ko03012,ko03029 Bacteria 2GK4M@201174,4DXP8@85010,COG0264@1,COG0264@2 NA|NA|NA J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome KOPIJCMJ_00096 1123320.KB889675_gene4072 2.9e-100 371.7 Actinobacteria pyrH GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006225,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009163,GO:0009165,GO:0009185,GO:0009188,GO:0009193,GO:0009194,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0033862,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042455,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046048,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046872,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 R00158 RC00002 ko00000,ko00001,ko01000 iSB619.SA_RS06240 Bacteria 2GKWQ@201174,COG0528@1,COG0528@2 NA|NA|NA F Catalyzes the reversible phosphorylation of UMP to UDP KOPIJCMJ_00097 1123320.KB889675_gene4071 1.4e-69 269.2 Actinobacteria frr GO:0002181,GO:0002184,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0030312,GO:0032984,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02838 ko00000,ko03012 Bacteria 2GJ9J@201174,COG0233@1,COG0233@2 NA|NA|NA J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another KOPIJCMJ_00098 65497.JODV01000002_gene4222 1.5e-70 273.1 Pseudonocardiales cdsA GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.41,2.7.7.67 ko:K00981,ko:K07098,ko:K19664 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799,R08966 RC00002 ko00000,ko00001,ko00002,ko01000 iLJ478.TM1397 Bacteria 2I7ZA@201174,4DYTX@85010,COG0575@1,COG0575@2 NA|NA|NA I Belongs to the CDS family KOPIJCMJ_00099 266940.Krad_1420 3.5e-147 528.1 Actinobacteria rlmN GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 ko:K06941 ko00000,ko01000,ko03009 Bacteria 2GJ48@201174,COG0820@1,COG0820@2 NA|NA|NA J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs KOPIJCMJ_00100 1035308.AQYY01000001_gene1460 0.0 1697.6 Bacteria 4.1.1.38 ko:K20370 ko00620,ko01100,map00620,map01100 R00346 RC02741 ko00000,ko00001,ko01000 Bacteria 28HY3@1,2Z83I@2 NA|NA|NA S phosphoenolpyruvate carboxykinase (diphosphate) activity KOPIJCMJ_00101 235985.BBPN01000048_gene8264 8e-78 297.4 Streptacidiphilus tesB GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016042,GO:0016054,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042802,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046483,GO:0047617,GO:0051186,GO:0055086,GO:0071704,GO:0072329,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901575 ko:K10805 ko01040,map01040 ko00000,ko00001,ko01000,ko01004 iAF1260.b0452,iB21_1397.B21_00408,iBWG_1329.BWG_0334,iEC55989_1330.EC55989_0466,iECBD_1354.ECBD_3203,iECB_1328.ECB_00404,iECDH10B_1368.ECDH10B_0408,iECDH1ME8569_1439.ECDH1ME8569_0437,iECD_1391.ECD_00404,iECH74115_1262.ECH74115_0541,iECIAI1_1343.ECIAI1_0456,iECIAI39_1322.ECIAI39_0221,iECO103_1326.ECO103_0429,iECO111_1330.ECO111_0485,iECO26_1355.ECO26_0487,iECSE_1348.ECSE_0478,iECSP_1301.ECSP_0520,iECUMN_1333.ECUMN_0492,iECW_1372.ECW_m0524,iECs_1301.ECs0506,iEKO11_1354.EKO11_3394,iETEC_1333.ETEC_0505,iEcDH1_1363.EcDH1_3157,iEcE24377_1341.EcE24377A_0488,iEcHS_1320.EcHS_A0529,iEcSMS35_1347.EcSMS35_0496,iEcolC_1368.EcolC_3163,iG2583_1286.G2583_0564,iJO1366.b0452,iSSON_1240.SSON_0440,iUMNK88_1353.UMNK88_505,iWFL_1372.ECW_m0524,iY75_1357.Y75_RS02335,iZ_1308.Z0564,ic_1306.c0571 Bacteria 2GJ1B@201174,2NEH9@228398,COG1946@1,COG1946@2 NA|NA|NA I Acyl-CoA thioesterase KOPIJCMJ_00102 1121877.JQKF01000002_gene1657 1.7e-263 916.0 Acidimicrobiia putA 1.2.1.88,1.5.5.2 ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 Bacteria 2GM5R@201174,4CNNB@84992,COG0506@1,COG0506@2,COG1012@1,COG1012@2 NA|NA|NA CE Proline dehydrogenase KOPIJCMJ_00103 219305.MCAG_03785 2.7e-162 578.6 Micromonosporales Bacteria 2GJQ9@201174,4DCEF@85008,COG0665@1,COG0665@2 NA|NA|NA E Glycine D-amino acid oxidases (deaminating) KOPIJCMJ_00104 367299.JOEE01000004_gene1059 4.1e-44 184.9 Intrasporangiaceae ko:K07005 ko00000 Bacteria 2GJ76@201174,4FGDI@85021,COG3467@1,COG3467@2 NA|NA|NA S Pyridoxamine 5'-phosphate oxidase KOPIJCMJ_00105 1380370.JIBA01000014_gene1864 5e-209 733.8 Intrasporangiaceae bioA Bacteria 2GKF6@201174,4FE6A@85021,COG0161@1,COG0161@2 NA|NA|NA H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family KOPIJCMJ_00106 1380354.JIAN01000007_gene161 2e-59 235.3 Actinobacteria asnC ko:K03718 ko00000,ko03000 Bacteria 2GP1P@201174,COG1522@1,COG1522@2 NA|NA|NA K AsnC family KOPIJCMJ_00107 526225.Gobs_1721 1.9e-211 741.9 Frankiales 1.2.1.8 ko:K00130 ko00260,ko01100,map00260,map01100 M00555 R02565,R02566 RC00080 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIWZ@201174,4ERRA@85013,COG1012@1,COG1012@2 NA|NA|NA C Belongs to the aldehyde dehydrogenase family KOPIJCMJ_00108 1396141.BATP01000059_gene2437 1.1e-109 403.3 Verrucomicrobiae ldhA 1.1.1.28 ko:K03778 ko00620,ko01120,map00620,map01120 R00704 RC00044 ko00000,ko00001,ko01000 Bacteria 2ITY0@203494,46SGM@74201,COG1052@1,COG1052@2 NA|NA|NA CH D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain KOPIJCMJ_00109 37919.EP51_00995 9.7e-195 686.4 Nocardiaceae 1.2.1.8 ko:K00130 ko00260,ko01100,map00260,map01100 M00555 R02565,R02566 RC00080 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIWZ@201174,4FTXB@85025,COG1012@1,COG1012@2 NA|NA|NA C Belongs to the aldehyde dehydrogenase family KOPIJCMJ_00110 1504319.GM45_4525 2.3e-117 429.1 unclassified Actinobacteria (class) ko:K11069 ko02010,map02010 M00299 ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 Bacteria 2GKVG@201174,3UWJS@52018,COG0687@1,COG0687@2 NA|NA|NA E Bacterial extracellular solute-binding protein KOPIJCMJ_00112 351607.Acel_1054 0.0 1282.7 Frankiales dnaE 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 2GJ1P@201174,4ERD2@85013,COG0587@1,COG0587@2 NA|NA|NA L DNA polymerase III alpha subunit KOPIJCMJ_00113 1123320.KB889675_gene3833 2.1e-48 198.7 Actinobacteria ybaK GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0043906,GO:0043907,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 ko:K03976 ko00000,ko01000,ko03016 Bacteria 2IHS8@201174,COG2606@1,COG2606@2 NA|NA|NA S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily KOPIJCMJ_00114 1048339.KB913029_gene4558 6.9e-39 167.5 Frankiales lonD 3.4.21.53 ko:K01338,ko:K07157 ko04112,map04112 ko00000,ko00001,ko01000,ko01002 Bacteria 2GNWA@201174,4ET5K@85013,COG2802@1,COG2802@2 NA|NA|NA S Peptidase S16, lon domain protein KOPIJCMJ_00115 1996.JOFO01000003_gene6293 2.3e-163 582.0 Streptosporangiales hisD GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23,1.1.1.308 ko:K00013,ko:K15509 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKKA@201174,4EHY2@85012,COG0141@1,COG0141@2 NA|NA|NA E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine KOPIJCMJ_00116 408672.NBCG_04907 1.1e-121 443.4 Propionibacteriales hisC GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 2GJ9W@201174,4DPP5@85009,COG0079@1,COG0079@2 NA|NA|NA E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily KOPIJCMJ_00117 710111.FraQA3DRAFT_6511 1.4e-75 289.3 Frankiales hisB GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0004424,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23,2.6.1.9,3.1.3.15,4.2.1.19 ko:K00013,ko:K00817,ko:K01089,ko:K01693 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R01158,R01163,R03012,R03013,R03243,R03457 RC00006,RC00017,RC00099,RC00242,RC00463,RC00888,RC00932 ko00000,ko00001,ko00002,ko01000,ko01007 iECO111_1330.ECO111_2746,iECS88_1305.ECS88_2121,iJN746.PP_0289,iLJ478.TM1039,iSB619.SA_RS14130,iUMNK88_1353.UMNK88_2570 Bacteria 2GKMD@201174,4ESDH@85013,COG0131@1,COG0131@2 NA|NA|NA E Imidazoleglycerol-phosphate dehydratase KOPIJCMJ_00118 1120960.ATXG01000009_gene10 2.1e-82 312.0 Microbacteriaceae hisH GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIYS@201174,4FKZP@85023,COG0118@1,COG0118@2 NA|NA|NA E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR KOPIJCMJ_00119 561175.KB894098_gene5366 3.6e-105 387.9 Streptosporangiales hisA GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16,5.3.1.24 ko:K01814,ko:K01817 ko00340,ko00400,ko01100,ko01110,ko01130,ko01230,map00340,map00400,map01100,map01110,map01130,map01230 M00023,M00026 R03509,R04640 RC00945 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ4V@201174,4EGBG@85012,COG0106@1,COG0106@2 NA|NA|NA E Histidine biosynthesis protein KOPIJCMJ_00120 1380347.JNII01000008_gene4164 5.4e-26 124.0 Frankiales 4.2.99.21 ko:K04782 ko01053,ko01110,ko01130,map01053,map01110,map01130 R06602 RC01549,RC02148 ko00000,ko00001,ko01000 Bacteria 2IIB2@201174,4ETK2@85013,COG0251@1,COG0251@2 NA|NA|NA J Endoribonuclease L-PSP KOPIJCMJ_00121 324602.Caur_0429 7.9e-07 61.2 Chloroflexia yvlD ko:K08972 ko00000 Bacteria 2G7E6@200795,375XQ@32061,COG1950@1,COG1950@2 NA|NA|NA S PFAM membrane protein of KOPIJCMJ_00122 1385517.N800_12005 1.4e-64 254.2 Xanthomonadales aarF ko:K03688 ko00000 Bacteria 1MU1Z@1224,1RNQ9@1236,1X410@135614,COG0661@1,COG0661@2 NA|NA|NA S Ubiquinone biosynthesis protein KOPIJCMJ_00123 227882.SAV_1926 7.5e-39 166.8 Actinobacteria Bacteria 2IIN1@201174,COG4803@1,COG4803@2 NA|NA|NA S membrane protein of uknown function UCP014873 KOPIJCMJ_00124 1120948.KB903243_gene2486 3.6e-14 84.3 Pseudonocardiales Bacteria 2E35Q@1,2GS2Q@201174,32Y5M@2,4E724@85010 NA|NA|NA S Short C-terminal domain KOPIJCMJ_00125 1449347.JQLN01000007_gene1639 8.5e-105 386.7 Kitasatospora hisF GO:0000107,GO:0003674,GO:0003824,GO:0008150,GO:0016740,GO:0016757,GO:0016763,GO:0040007 4.1.3.27 ko:K01657,ko:K02500 ko00340,ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00340,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023,M00026 R00985,R00986,R04558 RC00010,RC01190,RC01943,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIRP@201174,2M09X@2063,COG0107@1,COG0107@2 NA|NA|NA E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit KOPIJCMJ_00126 1236902.ANAS01000018_gene3245 7.2e-31 140.2 Streptosporangiales hisI GO:0008150,GO:0040007 3.5.4.19,3.6.1.31 ko:K01496,ko:K11755 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035,R04037 RC00002,RC01055 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1606 Bacteria 2IKKU@201174,4EJM8@85012,COG0139@1,COG0139@2 NA|NA|NA E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP KOPIJCMJ_00127 1157637.KB892090_gene6561 1.6e-184 652.5 Actinobacteria trpE 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKJT@201174,COG0147@1,COG0147@2 NA|NA|NA EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia KOPIJCMJ_00129 1463825.JNXC01000005_gene2492 3e-82 311.6 Pseudonocardiales Bacteria 2GJE6@201174,4DZNW@85010,COG0745@1,COG0745@2 NA|NA|NA T Transcriptional regulatory protein, C terminal KOPIJCMJ_00130 298653.Franean1_1613 8.3e-90 337.8 Frankiales Bacteria 2I53J@201174,4EU80@85013,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor KOPIJCMJ_00131 1463858.JOHR01000007_gene676 5.7e-15 87.4 Actinobacteria Bacteria 2E37T@1,2GQH5@201174,32Y7G@2 NA|NA|NA S Protein of unknown function (DUF2752) KOPIJCMJ_00132 1157635.KB892057_gene5130 3.6e-101 374.8 Actinobacteria trpC GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004425,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046391,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.48 ko:K01609 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508 RC00944 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIVV@201174,COG0134@1,COG0134@2 NA|NA|NA E Belongs to the TrpC family KOPIJCMJ_00133 1306174.JODP01000013_gene7463 2.6e-172 611.7 Actinobacteria trpB GO:0000162,GO:0003674,GO:0003824,GO:0004834,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 Bacteria 2GM7Z@201174,COG0133@1,COG0133@2 NA|NA|NA E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine KOPIJCMJ_00134 469371.Tbis_1452 2.3e-81 308.9 Pseudonocardiales trpA GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 Bacteria 2GN6T@201174,4E01I@85010,COG0159@1,COG0159@2 NA|NA|NA E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate KOPIJCMJ_00135 35754.JNYJ01000014_gene4756 1.1e-51 209.9 Micromonosporales Bacteria 2GMVK@201174,4DD9S@85008,COG4243@1,COG4243@2 NA|NA|NA S VKc KOPIJCMJ_00136 1504319.GM45_1285 2.9e-39 169.1 unclassified Actinobacteria (class) pknE_1 Bacteria 2GKH8@201174,3UWV7@52018,COG1651@1,COG1651@2 NA|NA|NA O Thioredoxin KOPIJCMJ_00137 1120950.KB892707_gene4971 1.4e-100 372.9 Propionibacteriales lgt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008961,GO:0009058,GO:0009059,GO:0009249,GO:0009898,GO:0009987,GO:0010467,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051604,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0140096,GO:1901564,GO:1901566,GO:1901576 2.1.1.199 ko:K03438,ko:K13292 ko00000,ko01000,ko03009 Bacteria 2GKSS@201174,4DP3T@85009,COG0682@1,COG0682@2 NA|NA|NA M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins KOPIJCMJ_00138 1032480.MLP_27620 7e-40 170.2 Propionibacteriales Bacteria 2AWFS@1,2IMS0@201174,31NC1@2,4DVM9@85009 NA|NA|NA KOPIJCMJ_00139 981369.JQMJ01000004_gene4916 1.3e-79 303.1 Streptacidiphilus gabT 2.6.1.19,2.6.1.22 ko:K00823,ko:K07250 ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648,R04188 RC00006,RC00062,RC00160 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 2GKVH@201174,2NI12@228398,COG0160@1,COG0160@2,COG2334@1,COG2334@2 NA|NA|NA E Aminotransferase class-III KOPIJCMJ_00140 1089545.KB913037_gene7763 4.6e-14 84.3 Pseudonocardiales dnaG GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 ko:K02316 ko03030,map03030 ko00000,ko00001,ko01000,ko03032 Bacteria 2GJFX@201174,4DXHS@85010,COG0358@1,COG0358@2 NA|NA|NA L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication KOPIJCMJ_00141 469371.Tbis_1189 1.6e-19 102.8 Actinobacteria hup GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009889,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2001141 ko:K03530 ko00000,ko03032,ko03036,ko03400 Bacteria 2IR95@201174,COG0776@1,COG0776@2 NA|NA|NA L regulation of translation KOPIJCMJ_00142 1122622.ATWJ01000013_gene243 1e-21 111.3 Intrasporangiaceae 4.4.1.32 ko:K02289 ko00196,ko01100,map00196,map01100 ko00000,ko00001,ko00194,ko01000 Bacteria 2GITU@201174,4FGE0@85021,COG1413@1,COG1413@2 NA|NA|NA C HEAT repeats KOPIJCMJ_00143 1035308.AQYY01000002_gene584 1.8e-39 170.2 Peptococcaceae nolA ko:K19591 M00769 ko00000,ko00002,ko01504,ko03000 Bacteria 1V8GZ@1239,25M6J@186801,26621@186807,COG0789@1,COG0789@2 NA|NA|NA K helix_turn_helix, mercury resistance KOPIJCMJ_00146 1907.SGLAU_10165 1.4e-53 216.9 Actinobacteria Bacteria 2GKT0@201174,COG0583@1,COG0583@2 NA|NA|NA K transcriptional regulator KOPIJCMJ_00149 1003195.SCAT_3393 1.2e-60 240.0 Actinobacteria trmB GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0040007,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.297,2.1.1.33,2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02493,ko:K02527,ko:K03439 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763,R10806 RC00003,RC00009,RC00077,RC00247,RC03279 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005,ko03012,ko03016 GT30 Bacteria 2GJ8R@201174,COG0220@1,COG0220@2 NA|NA|NA J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA KOPIJCMJ_00150 1385520.N802_05395 2.1e-64 252.3 Intrasporangiaceae 1.5.1.40 ko:K06988 ko00000,ko01000 Bacteria 2GMN3@201174,4FJWG@85021,COG2085@1,COG2085@2 NA|NA|NA S NADP oxidoreductase KOPIJCMJ_00151 298654.FraEuI1c_5203 5.3e-125 454.1 Frankiales yhhW_2 ko:K06911 ko00000 Bacteria 2GIY9@201174,4ES53@85013,COG1741@1,COG1741@2 NA|NA|NA S Belongs to the pirin family KOPIJCMJ_00152 1123322.KB904701_gene313 3.7e-107 394.8 Actinobacteria mutY ko:K03575 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 2GJD9@201174,COG1194@1,COG1194@2 NA|NA|NA L adenine glycosylase KOPIJCMJ_00155 512565.AMIS_45090 5.6e-93 347.8 Bacteria Bacteria COG1808@1,COG1808@2 NA|NA|NA S Domain of unknown function (DUF389) KOPIJCMJ_00156 1236902.ANAS01000009_gene2473 3e-74 286.2 Streptosporangiales 3.5.1.104 ko:K22278 ko00000,ko01000 Bacteria 2HEQK@201174,4EI91@85012,COG0726@1,COG0726@2 NA|NA|NA G Polysaccharide deacetylase KOPIJCMJ_00160 1095767.CAHD01000133_gene1273 1.5e-227 795.4 Cellulomonadaceae guaB GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006183,GO:0006195,GO:0006204,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009125,GO:0009126,GO:0009127,GO:0009128,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009154,GO:0009156,GO:0009158,GO:0009161,GO:0009163,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009169,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009261,GO:0009987,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046037,GO:0046039,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0072523,GO:0090407,GO:0097292,GO:0097293,GO:1901068,GO:1901070,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GITZ@201174,4F0EC@85016,COG0516@1,COG0516@2,COG0517@1,COG0517@2 NA|NA|NA F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth KOPIJCMJ_00161 1306174.JODP01000006_gene3624 5.1e-65 254.2 Actinobacteria bldM Bacteria 2GN46@201174,COG2197@1,COG2197@2 NA|NA|NA K Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain KOPIJCMJ_00162 710421.Mycch_1110 7.9e-14 84.7 Mycobacteriaceae Bacteria 233QX@1762,2F0NR@1,2GUJF@201174,33TR6@2 NA|NA|NA KOPIJCMJ_00163 1449976.KALB_8154 2.4e-38 166.0 Pseudonocardiales litR ko:K22491 ko00000,ko03000 Bacteria 2I8T8@201174,4DZZC@85010,COG0789@1,COG0789@2 NA|NA|NA K MerR HTH family regulatory protein KOPIJCMJ_00164 1380393.JHVP01000002_gene1784 1.5e-140 505.8 Frankiales mdh 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 Bacteria 2GN5S@201174,4ESBM@85013,COG0039@1,COG0039@2 NA|NA|NA C Catalyzes the reversible oxidation of malate to oxaloacetate KOPIJCMJ_00165 998088.B565_1091 1.5e-24 119.4 Proteobacteria Bacteria 1NKFS@1224,COG3832@1,COG3832@2 NA|NA|NA S Activator of Hsp90 ATPase homolog 1-like protein KOPIJCMJ_00166 1003195.SCAT_2410 1.2e-20 106.7 Actinobacteria ligT GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008104,GO:0008150,GO:0009966,GO:0010646,GO:0010738,GO:0023051,GO:0033036,GO:0034237,GO:0044424,GO:0044444,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051018,GO:0051179,GO:0065007,GO:1902531 3.1.4.58 ko:K01975 ko00000,ko01000,ko03016 Bacteria 2GNDN@201174,COG1514@1,COG1514@2 NA|NA|NA J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester KOPIJCMJ_00167 710111.FraQA3DRAFT_1948 1.8e-149 536.2 Frankiales Bacteria 28H9S@1,2HZP4@201174,2Z7ME@2,4EU66@85013 NA|NA|NA S GDSL-like Lipase/Acylhydrolase KOPIJCMJ_00169 1386089.N865_19910 3.2e-119 435.3 Intrasporangiaceae ko:K07222 ko00000 Bacteria 2GM3S@201174,4FFFI@85021,COG2072@1,COG2072@2 NA|NA|NA P L-lysine 6-monooxygenase (NADPH-requiring) KOPIJCMJ_00171 749927.AMED_5979 3.3e-13 80.5 Pseudonocardiales Bacteria 2E3V5@1,2GTV6@201174,345UQ@2,4ED36@85010 NA|NA|NA S Homeodomain-like domain KOPIJCMJ_00172 1110697.NCAST_20_03040 6.3e-22 110.9 Nocardiaceae Bacteria 2IRV0@201174,4G0MZ@85025,COG0542@1,COG0542@2 NA|NA|NA O Clp amino terminal domain, pathogenicity island component KOPIJCMJ_00173 710696.Intca_0451 7.1e-304 1049.7 Intrasporangiaceae 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 GH31 Bacteria 2GP4V@201174,4FG4A@85021,COG1501@1,COG1501@2 NA|NA|NA G Glycosyl hydrolases family 31 KOPIJCMJ_00175 1123320.KB889585_gene1745 3.6e-76 292.4 Actinobacteria rsmC ko:K00612 ko00000,ko01000 Bacteria 2GJPP@201174,COG2890@1,COG2890@2 NA|NA|NA J methyltransferase KOPIJCMJ_00176 1123322.KB904713_gene5176 1e-285 989.6 Actinobacteria topA GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009892,GO:0010605,GO:0016020,GO:0016853,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0040007,GO:0043086,GO:0043167,GO:0043169,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060700,GO:0060701,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0140097 5.99.1.2 ko:K03168 ko00000,ko01000,ko03032,ko03400 Bacteria 2GJU7@201174,COG0550@1,COG0550@2,COG1754@1,COG1754@2 NA|NA|NA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone KOPIJCMJ_00177 1123322.KB904692_gene4469 1.1e-70 272.7 Actinobacteria carD GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0040007,GO:0042594,GO:0044419,GO:0050896,GO:0051704,GO:0051716,GO:0071496 ko:K07736 ko00000,ko03000 Bacteria 2GKSU@201174,COG1329@1,COG1329@2 NA|NA|NA K transcriptional regulator KOPIJCMJ_00178 351607.Acel_0079 1.2e-69 270.4 Bacteria yacL GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 Bacteria COG4956@1,COG4956@2 NA|NA|NA S nuclease activity KOPIJCMJ_00179 862751.SACTE_3674 9.5e-47 193.7 Actinobacteria ispD GO:0000166,GO:0000287,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016114,GO:0016740,GO:0016772,GO:0016779,GO:0019103,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044464,GO:0046490,GO:0046872,GO:0046914,GO:0050518,GO:0051483,GO:0051484,GO:0070567,GO:0071704,GO:0071944,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.405,2.7.7.40,2.7.7.60,4.6.1.12 ko:K00991,ko:K12506,ko:K21681 ko00040,ko00900,ko01100,ko01110,ko01130,map00040,map00900,map01100,map01110,map01130 M00096 R01525,R02921,R05633,R05637 RC00002,RC00089,RC01440 ko00000,ko00001,ko00002,ko01000 Bacteria 2GNHP@201174,COG1211@1,COG1211@2 NA|NA|NA I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) KOPIJCMJ_00180 390989.JOEG01000009_gene1007 3.6e-56 224.6 Micromonosporales ispF GO:0003674,GO:0003824,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008685,GO:0009058,GO:0009987,GO:0016114,GO:0016829,GO:0016849,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0051483,GO:0071704,GO:1901576 2.1.1.228,2.7.7.60,4.6.1.12 ko:K00554,ko:K01770,ko:K12506 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R00597,R05633,R05637 RC00002,RC00003,RC00334,RC01440 ko00000,ko00001,ko00002,ko01000,ko03016 iNJ661.Rv3581c Bacteria 2II8H@201174,4DDC4@85008,COG0245@1,COG0245@2 NA|NA|NA I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) KOPIJCMJ_00181 446468.Ndas_4314 2.1e-159 568.9 Streptosporangiales cysS GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16,6.3.1.13 ko:K01883,ko:K15526 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 2GJF2@201174,4EFX4@85012,COG0215@1,COG0215@2 NA|NA|NA J DALR_2 KOPIJCMJ_00182 66377.JOBH01000005_gene2852 5.1e-96 357.8 Actinobacteria rlmB GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.185 ko:K03218 ko00000,ko01000,ko03009 Bacteria 2GJMR@201174,COG0566@1,COG0566@2 NA|NA|NA J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family KOPIJCMJ_00183 1502852.FG94_03642 3.7e-29 135.6 Betaproteobacteria 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 GH31 Bacteria 1RAB4@1224,2VTPF@28216,COG2819@1,COG2819@2 NA|NA|NA S Putative esterase KOPIJCMJ_00184 1380354.JIAN01000005_gene2883 1.6e-124 453.0 Cellulomonadaceae inaA ko:K02848 ko00540,ko01100,map00540,map01100 M00080 ko00000,ko00001,ko00002,ko01000,ko01005 Bacteria 2GIX0@201174,4F13Z@85016,COG3642@1,COG3642@2 NA|NA|NA T Domain of unknown function (DUF4032) KOPIJCMJ_00186 479431.Namu_4682 4.7e-159 568.2 Actinobacteria malZ GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0004558,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009311,GO:0009313,GO:0009987,GO:0015926,GO:0016052,GO:0016787,GO:0016798,GO:0030978,GO:0030980,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044464,GO:0051691,GO:0051692,GO:0071704,GO:0090599,GO:1901575 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 GH31 iECH74115_1262.ECH74115_0480,iEcSMS35_1347.EcSMS35_0434,iSFV_1184.SFV_0368,iYL1228.KPN_00344 Bacteria 2GJUT@201174,COG0366@1,COG0366@2 NA|NA|NA G alpha amylase, catalytic KOPIJCMJ_00187 479431.Namu_4683 3.9e-79 301.2 Frankiales ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 ko00000,ko00001,ko00002,ko02000 3.A.1.1 Bacteria 2GJCM@201174,4ES4E@85013,COG3842@1,COG3842@2 NA|NA|NA P Belongs to the ABC transporter superfamily KOPIJCMJ_00190 235985.BBPN01000004_gene3114 1.3e-32 147.1 Streptacidiphilus apbE 2.7.1.180 ko:K03734 ko00000,ko01000 Bacteria 2H74Y@201174,2NF9E@228398,COG1477@1,COG1477@2 NA|NA|NA H ApbE family KOPIJCMJ_00191 1206731.BAGB01000163_gene7753 3.8e-19 101.7 Nocardiaceae Bacteria 2GQH2@201174,4G1BH@85025,COG4097@1,COG4097@2 NA|NA|NA P Ferric reductase like transmembrane component KOPIJCMJ_00192 66429.JOFL01000001_gene4522 3.9e-48 199.1 Actinobacteria nuoF2 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2GNN9@201174,COG1894@1,COG1894@2 NA|NA|NA C NADH ubiquinone oxidoreductase NADH-binding (51 kD) subunit KOPIJCMJ_00193 66377.JOBH01000010_gene6019 6.8e-66 257.3 Actinobacteria Bacteria 2GMVN@201174,COG0745@1,COG0745@2 NA|NA|NA T response regulator KOPIJCMJ_00194 196162.Noca_4423 4.8e-49 202.2 Propionibacteriales 2.7.13.3 ko:K02484,ko:K07653,ko:K07654 ko02020,map02020 M00460,M00461 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 2I3U8@201174,4DU9B@85009,COG5002@1,COG5002@2 NA|NA|NA T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain KOPIJCMJ_00195 1240349.ANGC01000055_gene4012 2.7e-146 525.8 Nocardiaceae yciQ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 2GNW7@201174,4G3G3@85025,COG4907@1,COG4907@2 NA|NA|NA S Predicted membrane protein (DUF2207) KOPIJCMJ_00196 110319.CF8_0638 1.6e-57 229.2 Actinobacteria lemA ko:K03744 ko00000 Bacteria 2GPS4@201174,COG1704@1,COG1704@2 NA|NA|NA J LemA family KOPIJCMJ_00197 1172188.KB911823_gene665 3.3e-85 322.4 Intrasporangiaceae Bacteria 2I37Q@201174,4FFGA@85021,COG0025@1,COG0025@2 NA|NA|NA P Sodium/hydrogen exchanger family KOPIJCMJ_00198 35754.JNYJ01000038_gene4979 5e-74 284.6 Micromonosporales ku ko:K10979 ko03450,map03450 ko00000,ko00001,ko03400 Bacteria 2GJMU@201174,4D9ZY@85008,COG1273@1,COG1273@2 NA|NA|NA L With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD KOPIJCMJ_00199 349521.HCH_05422 2.6e-25 122.1 Oceanospirillales FolA Bacteria 1RH02@1224,1S2UN@1236,1XKZU@135619,COG0262@1,COG0262@2 NA|NA|NA H RibD C-terminal domain KOPIJCMJ_00200 263358.VAB18032_25150 3.1e-100 372.1 Micromonosporales Bacteria 2GK0T@201174,4DCHZ@85008,COG3214@1,COG3214@2 NA|NA|NA S Winged helix DNA-binding domain KOPIJCMJ_00201 446465.Bfae_27310 2.2e-85 322.8 Dermabacteraceae sbcD ko:K03547 ko00000,ko03400 Bacteria 2GK9R@201174,4FBAD@85020,COG0420@1,COG0420@2 NA|NA|NA L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity KOPIJCMJ_00202 1246448.ANAZ01000004_gene4671 4.9e-105 389.4 Streptosporangiales sbcC GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006260,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360,GO:1901576 ko:K03546 ko00000,ko03400 Bacteria 2GKYR@201174,4EG84@85012,COG0419@1,COG0419@2 NA|NA|NA L AAA domain KOPIJCMJ_00203 1211815.CBYP010000051_gene667 2.2e-97 362.8 Frankiales pdhC 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GM0D@201174,4ERC0@85013,COG0508@1,COG0508@2 NA|NA|NA C of components of various dehydrogenase complexes KOPIJCMJ_00204 469371.Tbis_3331 6.3e-126 457.2 Pseudonocardiales pdhB GO:0003674,GO:0005488,GO:0005515,GO:0140030,GO:0140032 1.2.4.1 ko:K00162,ko:K21417 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS05355,iYO844.BSU14590 Bacteria 2GKFE@201174,4E0CR@85010,COG0022@1,COG0022@2 NA|NA|NA C Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase component beta subunit KOPIJCMJ_00205 105425.BBPL01000021_gene769 5.7e-136 490.7 Streptacidiphilus pdhA 1.2.4.1 ko:K00161 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GK3W@201174,2NFED@228398,COG1071@1,COG1071@2 NA|NA|NA C Dehydrogenase E1 component KOPIJCMJ_00206 105420.BBPO01000043_gene3657 8.1e-77 293.9 Streptacidiphilus ko:K07052 ko00000 Bacteria 2GK11@201174,2NHZA@228398,COG1266@1,COG1266@2 NA|NA|NA S CAAX protease self-immunity KOPIJCMJ_00207 1089545.KB913037_gene6123 9.9e-95 354.0 Pseudonocardiales GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0040007,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.4.1.11,2.4.1.18 ko:K16149,ko:K16150 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R00292,R02110 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 GH57,GT4 Bacteria 2I2EE@201174,4DZ70@85010,COG0297@1,COG0297@2 NA|NA|NA G Glycosyl transferases group 1 KOPIJCMJ_00208 469371.Tbis_2846 1.7e-84 319.3 Pseudonocardiales etfB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016020,GO:0016491,GO:0016627,GO:0016628,GO:0022900,GO:0030312,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071944,GO:0071949,GO:0097159,GO:1901265,GO:1901363 1.3.1.108 ko:K03521,ko:K22431 ko00000,ko01000 iAF987.Gmet_2067,iHN637.CLJU_RS19405 Bacteria 2GKV6@201174,4E0JQ@85010,COG2086@1,COG2086@2 NA|NA|NA C Electron transfer flavoprotein KOPIJCMJ_00209 561175.KB894094_gene1960 3.5e-105 388.3 Streptosporangiales etfA GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 ko:K03522 ko00000,ko04147 Bacteria 2GJWH@201174,4EGI3@85012,COG2025@1,COG2025@2 NA|NA|NA C Electron transfer flavoprotein domain KOPIJCMJ_00210 1348663.KCH_51370 3.8e-120 438.3 Kitasatospora iscS GO:0003674,GO:0003824,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0016783,GO:0022607,GO:0031071,GO:0031163,GO:0040007,GO:0044085,GO:0044237,GO:0051186,GO:0071840 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 Bacteria 2GKUT@201174,2M12X@2063,COG1104@1,COG1104@2 NA|NA|NA E Beta-eliminating lyase KOPIJCMJ_00211 452652.KSE_51040 2.9e-132 478.4 Kitasatospora mnmA 2.8.1.13 ko:K00566 ko04122,map04122 R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 Bacteria 2GIUQ@201174,2M13X@2063,COG0482@1,COG0482@2 NA|NA|NA J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 KOPIJCMJ_00212 1123251.ATWM01000001_gene699 1.3e-43 183.3 Intrasporangiaceae Bacteria 2GN6R@201174,4FFT4@85021,COG1296@1,COG1296@2 NA|NA|NA E branched-chain amino acid KOPIJCMJ_00213 1172188.KB911821_gene1287 1.1e-15 89.4 Intrasporangiaceae Bacteria 2E45J@1,2GR89@201174,32Z1K@2,4FHGH@85021 NA|NA|NA S Branched-chain amino acid transport protein (AzlD) KOPIJCMJ_00214 1122919.KB905604_gene4558 1.3e-81 310.1 Paenibacillaceae ygjR GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0055114,GO:0102497 ko:K22230 ko00562,ko01120,map00562,map01120 R09954 RC00182 ko00000,ko00001,ko01000 Bacteria 1TQSS@1239,26SCY@186822,4HCIG@91061,COG0673@1,COG0673@2 NA|NA|NA S Oxidoreductase KOPIJCMJ_00215 981369.JQMJ01000004_gene5729 5.6e-61 241.5 Streptacidiphilus 2.1.1.14 ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R04405,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 Bacteria 2GMPS@201174,2NF4D@228398,COG0620@1,COG0620@2 NA|NA|NA E Cobalamin-independent synthase, Catalytic domain KOPIJCMJ_00216 266940.Krad_1315 2.3e-227 795.4 Actinobacteria ligA GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016874,GO:0016886,GO:0030312,GO:0033554,GO:0034641,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 Bacteria 2GJUY@201174,COG0272@1,COG0272@2 NA|NA|NA L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA KOPIJCMJ_00217 1122182.KB903834_gene5703 3.4e-25 120.9 Micromonosporales gatC GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 Bacteria 2IQJN@201174,4DEPX@85008,COG0721@1,COG0721@2 NA|NA|NA J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) KOPIJCMJ_00220 1122998.AUHZ01000010_gene1513 1.2e-10 72.4 Propionibacteriales csoR GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010038,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0042221,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0046688,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 ko:K21600 ko00000,ko03000 Bacteria 2IQAC@201174,4DRND@85009,COG1937@1,COG1937@2 NA|NA|NA S Metal-sensitive transcriptional repressor KOPIJCMJ_00222 196162.Noca_3785 6.6e-55 220.7 Propionibacteriales 1.11.1.15 ko:K03386,ko:K03564,ko:K16922 ko04214,map04214 ko00000,ko00001,ko01000,ko01002,ko04147 Bacteria 2IGFI@201174,4DRG7@85009,COG1225@1,COG1225@2 NA|NA|NA O Redoxin KOPIJCMJ_00223 1122609.AUGT01000027_gene2723 2.2e-113 415.6 Propionibacteriales Bacteria 2GMXW@201174,4DTAU@85009,COG0785@1,COG0785@2 NA|NA|NA O Cytochrome C biogenesis protein transmembrane region KOPIJCMJ_00224 446466.Cfla_0354 3.4e-17 94.4 Bacteria Bacteria COG0695@1,COG0695@2 NA|NA|NA O Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins KOPIJCMJ_00225 1429046.RR21198_4564 2.3e-16 91.3 Nocardiaceae Bacteria 2GIX7@201174,4G094@85025,COG5002@1,COG5002@2 NA|NA|NA T His Kinase A (phosphoacceptor) domain KOPIJCMJ_00226 1121019.AUMN01000020_gene1650 4.5e-53 214.5 Micrococcaceae Bacteria 1WCG3@1268,2I3S1@201174,COG1476@1,COG1476@2 NA|NA|NA K Helix-turn-helix XRE-family like proteins KOPIJCMJ_00227 290340.AAur_3965 1.2e-78 300.1 Micrococcaceae rhtA GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015175,GO:0015179,GO:0015195,GO:0015238,GO:0015318,GO:0015562,GO:0015565,GO:0015711,GO:0015804,GO:0015807,GO:0015826,GO:0015849,GO:0015893,GO:0016020,GO:0022857,GO:0034220,GO:0034639,GO:0042221,GO:0042493,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903825,GO:1905039 ko:K11939 ko00000,ko02000 2.A.7.3.6 Bacteria 1W96S@1268,2GJKB@201174,COG5006@1,COG5006@2 NA|NA|NA S EamA-like transporter family KOPIJCMJ_00228 1449355.JQNR01000005_gene3991 1.1e-98 366.3 Actinobacteria uppS 2.5.1.31,2.5.1.68 ko:K00806,ko:K12503 ko00900,ko01110,map00900,map01110 R06447,R08528 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 Bacteria 2GJCP@201174,COG0020@1,COG0020@2 NA|NA|NA I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids KOPIJCMJ_00229 1121385.AQXW01000001_gene776 1.9e-54 219.2 Dermacoccaceae yplQ ko:K11068 ko00000,ko02042 Bacteria 1ZW8F@145357,2GJGQ@201174,COG1272@1,COG1272@2 NA|NA|NA S hemolysin III KOPIJCMJ_00230 644283.Micau_2172 2.7e-90 338.6 Micromonosporales xth 3.1.11.2,6.5.1.1 ko:K01142,ko:K01971 ko03410,ko03450,map03410,map03450 R00381 RC00005 ko00000,ko00001,ko01000,ko03400 Bacteria 2GKEW@201174,4D92U@85008,COG0708@1,COG0708@2 NA|NA|NA L exodeoxyribonuclease III KOPIJCMJ_00231 1894.JOER01000030_gene416 1.4e-37 163.3 Actinobacteria Bacteria 2GMRP@201174,COG4758@1,COG4758@2 NA|NA|NA S Cell wall-active antibiotics response 4TMS YvqF KOPIJCMJ_00232 369723.Strop_3578 3.9e-14 84.3 Micromonosporales GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 Bacteria 2E65S@1,2IMEQ@201174,330UF@2,4DERM@85008 NA|NA|NA S Domain of unknown function (DUF3817) KOPIJCMJ_00233 1210045.ALNP01000011_gene1032 3.6e-25 122.1 Actinobacteria surf1 ko:K14998 ko00000,ko03029 3.D.4.8 Bacteria 2GMGB@201174,COG3346@1,COG3346@2 NA|NA|NA S SURF1-like protein KOPIJCMJ_00235 994479.GL877878_gene2035 1.4e-12 79.7 Pseudonocardiales Bacteria 2DRBP@1,2IGPY@201174,33B4I@2,4E5JR@85010 NA|NA|NA S Domain of unknown function (DUF4307) KOPIJCMJ_00236 1504319.GM45_3100 5.2e-44 184.1 unclassified Actinobacteria (class) greA GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006354,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0030312,GO:0031323,GO:0031326,GO:0032774,GO:0032784,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 ko:K03624 ko00000,ko03021 Bacteria 2GNZV@201174,3UWPU@52018,COG0782@1,COG0782@2 NA|NA|NA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides KOPIJCMJ_00237 526225.Gobs_0935 1.6e-131 476.1 Frankiales ilvA 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 iLJ478.TM0356 Bacteria 2GJAG@201174,4ES0N@85013,COG1171@1,COG1171@2 NA|NA|NA E PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit KOPIJCMJ_00238 1435356.Y013_00880 6.6e-93 347.1 Nocardiaceae ung GO:0003674,GO:0003824,GO:0004844,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0097510,GO:0140097,GO:1901360 3.2.2.27 ko:K03648 ko03410,ko05340,map03410,map05340 ko00000,ko00001,ko01000,ko03400 Bacteria 2GJ9Z@201174,4FXPC@85025,COG0692@1,COG0692@2 NA|NA|NA L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine KOPIJCMJ_00239 1122622.ATWJ01000012_gene1048 7.4e-109 401.0 Intrasporangiaceae ftsA ko:K03590 ko04112,map04112 ko00000,ko00001,ko03036,ko04812 Bacteria 2GK4G@201174,4FFED@85021,COG0849@1,COG0849@2 NA|NA|NA D Glutamate mutase KOPIJCMJ_00240 287986.DV20_10395 4e-59 235.7 Pseudonocardiales ko:K02027,ko:K17329 ko02010,map02010 M00207,M00606 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.33 Bacteria 2GKM8@201174,4DYH5@85010,COG1653@1,COG1653@2 NA|NA|NA G Bacterial extracellular solute-binding protein KOPIJCMJ_00241 743718.Isova_2471 5.4e-68 264.2 Promicromonosporaceae msrA 1.8.4.11 ko:K07304 ko00000,ko01000 Bacteria 2GJ1S@201174,4F34W@85017,COG0225@1,COG0225@2 NA|NA|NA O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine KOPIJCMJ_00242 1048339.KB913029_gene142 3e-52 212.2 Frankiales Bacteria 2GMVS@201174,4ESHM@85013,COG2755@1,COG2755@2 NA|NA|NA E GDSL-like Lipase/Acylhydrolase KOPIJCMJ_00244 479433.Caci_0641 9.9e-22 109.0 Actinobacteria Bacteria 2E5A7@1,2IQ7Z@201174,3302F@2 NA|NA|NA S Domain of unknown function (DUF4287) KOPIJCMJ_00245 1121385.AQXW01000004_gene3385 1.5e-12 78.2 Dermacoccaceae Bacteria 1ZW05@145357,2GNCK@201174,COG4760@1,COG4760@2 NA|NA|NA S Bax inhibitor 1 like KOPIJCMJ_00246 344747.PM8797T_31840 4.6e-22 111.7 Planctomycetes Bacteria 2E296@1,2J070@203682,32XEW@2 NA|NA|NA KOPIJCMJ_00248 653045.Strvi_9002 6.2e-100 370.9 Actinobacteria arsA GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 3.6.3.16 ko:K01551 ko00000,ko01000,ko02000 3.A.19.1,3.A.21.1,3.A.4.1 Bacteria 2GJ0J@201174,COG0003@1,COG0003@2 NA|NA|NA D Pfam Anion-transporting ATPase KOPIJCMJ_00249 105420.BBPO01000071_gene4045 5.4e-140 504.2 Streptacidiphilus arsA 3.6.3.16 ko:K01551 ko00000,ko01000,ko02000 3.A.19.1,3.A.21.1,3.A.4.1 Bacteria 2GJYN@201174,2NHKM@228398,COG0003@1,COG0003@2 NA|NA|NA D Anion-transporting ATPase KOPIJCMJ_00250 1504319.GM45_3810 1.2e-180 640.2 unclassified Actinobacteria (class) pon1 2.4.1.129,3.4.16.4 ko:K05365,ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 GT51 Bacteria 2GK21@201174,3UW69@52018,COG0744@1,COG0744@2 NA|NA|NA M Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology KOPIJCMJ_00251 1137269.AZWL01000006_gene6602 1.2e-31 142.9 Actinobacteria yqeY ko:K09117 ko00000 Bacteria 2IFFJ@201174,COG1610@1,COG1610@2 NA|NA|NA S GatB YqeY KOPIJCMJ_00252 1120950.KB892762_gene5503 3.5e-78 298.5 Propionibacteriales ykuE ko:K07098 ko00000 Bacteria 2GJHT@201174,4DNBM@85009,COG1408@1,COG1408@2 NA|NA|NA S Calcineurin-like phosphoesterase KOPIJCMJ_00254 1906.SFRA_16445 3.4e-25 122.1 Actinobacteria 2.7.7.87 ko:K07566 R10463 RC00745 ko00000,ko01000,ko03009,ko03016 Bacteria 2IKIN@201174,COG4902@1,COG4902@2 NA|NA|NA S Uncharacterized protein domain (DUF2202) KOPIJCMJ_00255 1035308.AQYY01000002_gene880 2.7e-82 312.8 Clostridia 2.7.13.3 ko:K02484,ko:K07768 ko02020,map02020 M00443 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 1TQ1H@1239,247VG@186801,COG5002@1,COG5002@2 NA|NA|NA T Histidine kinase KOPIJCMJ_00256 1035308.AQYY01000002_gene879 1.6e-74 285.8 Clostridia Bacteria 1TS81@1239,248XH@186801,COG0745@1,COG0745@2 NA|NA|NA T response regulator receiver KOPIJCMJ_00258 1035308.AQYY01000001_gene3237 1.1e-195 689.5 Clostridia 1.8.5.4 ko:K17218 ko00920,map00920 R10152 RC03155 ko00000,ko00001,ko01000 Bacteria 1V11U@1239,25BW0@186801,COG0446@1,COG0446@2 NA|NA|NA S Pyridine nucleotide-disulphide oxidoreductase KOPIJCMJ_00259 1304865.JAGF01000001_gene3278 0.0 1120.1 Cellulomonadaceae cdr ko:K04085 ko04122,map04122 ko00000,ko00001,ko01000,ko03016 Bacteria 2H7WY@201174,4F10M@85016,COG0446@1,COG0446@2,COG0607@1,COG0607@2,COG2210@1,COG2210@2 NA|NA|NA P PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase KOPIJCMJ_00260 1051632.TPY_2536 7.8e-23 113.2 Firmicutes Bacteria 1W45F@1239,COG1433@1,COG1433@2 NA|NA|NA S Dinitrogenase iron-molybdenum cofactor KOPIJCMJ_00261 1035308.AQYY01000002_gene111 7.8e-59 234.6 Peptococcaceae Bacteria 1V0ES@1239,24Q6Z@186801,26717@186807,COG1275@1,COG1275@2 NA|NA|NA P Voltage-dependent anion channel KOPIJCMJ_00262 446469.Sked_03560 1.4e-118 433.3 Actinobacteria phoA 3.1.3.1 ko:K01077 ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020 M00126 R02135,R04620 RC00017 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 Bacteria 2GM8A@201174,COG1785@1,COG1785@2 NA|NA|NA P Belongs to the alkaline phosphatase family KOPIJCMJ_00263 1064537.AGSO01000003_gene1096 8.1e-29 134.4 Dermabacteraceae ko:K07090 ko00000 Bacteria 2I5VT@201174,4FCQ5@85020,COG0730@1,COG0730@2 NA|NA|NA S Sulfite exporter TauE/SafE KOPIJCMJ_00264 55952.BU52_25740 1.9e-134 486.1 Actinobacteria 3.1.2.6 ko:K01069 ko00620,map00620 R01736 RC00004,RC00137 ko00000,ko00001,ko01000 Bacteria 2GN50@201174,COG0491@1,COG0491@2,COG0607@1,COG0607@2 NA|NA|NA P PFAM beta-lactamase domain protein KOPIJCMJ_00265 1123309.AQYB01000031_gene361 3.7e-19 100.9 Bacilli pspE Bacteria 1VES3@1239,4HNRE@91061,COG0607@1,COG0607@2 NA|NA|NA P COG0607 Rhodanese-related sulfurtransferase KOPIJCMJ_00268 1121946.AUAX01000005_gene5377 1.2e-207 729.6 Micromonosporales csdA 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 Bacteria 2GP7W@201174,4DAKS@85008,COG0520@1,COG0520@2 NA|NA|NA E Aminotransferase class-V KOPIJCMJ_00269 1184607.AUCHE_05_03520 2.5e-34 152.1 Actinobacteria mauF 2.7.11.1 ko:K03466,ko:K06196,ko:K12132 ko00000,ko01000,ko01001,ko02000,ko03036 3.A.12,5.A.1.2 Bacteria 2IMP9@201174,COG0785@1,COG0785@2 NA|NA|NA O Cytochrome C biogenesis protein KOPIJCMJ_00270 1122622.ATWJ01000002_gene818 6.2e-24 117.1 Intrasporangiaceae ko:K03972 ko00000 Bacteria 2GR81@201174,4FHT9@85021,COG0607@1,COG0607@2 NA|NA|NA P Rhodanese Homology Domain KOPIJCMJ_00271 1172188.KB911824_gene3388 6.6e-128 464.5 Intrasporangiaceae Bacteria 2GM2C@201174,4FEF8@85021,COG2898@1,COG2898@2 NA|NA|NA S Uncharacterised conserved protein (DUF2156) KOPIJCMJ_00276 134676.ACPL_5940 1.7e-28 133.3 Micromonosporales dnaG ko:K02316 ko03030,map03030 ko00000,ko00001,ko01000,ko03032 Bacteria 2IIZM@201174,4DH41@85008,COG0358@1,COG0358@2 NA|NA|NA L Toprim-like KOPIJCMJ_00277 263358.VAB18032_30319 1.4e-12 81.3 Micromonosporales Bacteria 2DRVP@1,2GQDR@201174,33D9Z@2,4DE7K@85008 NA|NA|NA KOPIJCMJ_00278 397278.JOJN01000013_gene2576 3.4e-22 112.1 Propionibacteriales Bacteria 2HKN7@201174,4DQJH@85009,COG1261@1,COG1261@2 NA|NA|NA NO SAF KOPIJCMJ_00282 405948.SACE_3492 1.2e-100 373.2 Pseudonocardiales MA20_17565 Bacteria 2GNZT@201174,4DZ7M@85010,COG0265@1,COG0265@2 NA|NA|NA O C-terminal PDZ domain KOPIJCMJ_00283 1540221.JQNI01000002_gene2504 2.7e-42 177.9 Deinococcus-Thermus Bacteria 1WKYF@1297,COG1028@1,COG1028@2 NA|NA|NA IQ PFAM short chain dehydrogenase KOPIJCMJ_00284 1380347.JNII01000005_gene2849 4.3e-48 198.0 Frankiales ko:K10947 ko00000,ko03000 Bacteria 2IFDN@201174,4ET5U@85013,COG1695@1,COG1695@2 NA|NA|NA K Transcriptional regulator KOPIJCMJ_00285 469371.Tbis_0943 7.5e-72 276.9 Pseudonocardiales rdgB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66,5.1.1.3 ko:K01776,ko:K02428 ko00230,ko00471,ko01100,map00230,map00471,map01100 R00260,R00426,R00720,R01855,R02100,R02720,R03531 RC00002,RC00302 ko00000,ko00001,ko01000,ko01011 Bacteria 2GM2B@201174,4E0TE@85010,COG0127@1,COG0127@2 NA|NA|NA F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions KOPIJCMJ_00286 266940.Krad_3763 7.5e-95 353.6 Actinobacteria rph GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006401,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043170,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:1901361,GO:1901575 2.7.7.56,3.6.1.66 ko:K00989,ko:K02428 ko00230,map00230 R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000,ko03016 Bacteria 2GJFI@201174,COG0689@1,COG0689@2 NA|NA|NA J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates KOPIJCMJ_00287 1394178.AWOO02000078_gene2041 1e-70 273.5 Streptosporangiales yhfI GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267 Bacteria 2GMEX@201174,4EIG9@85012,COG1234@1,COG1234@2 NA|NA|NA S Beta-lactamase superfamily domain KOPIJCMJ_00290 1123320.KB889675_gene3934 3.1e-128 464.9 Actinobacteria adoK GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004001,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005975,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019200,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032552,GO:0032553,GO:0032554,GO:0032555,GO:0032559,GO:0032560,GO:0032561,GO:0032567,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046390,GO:0046483,GO:0046835,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.15,2.7.1.20 ko:K00852,ko:K00856 ko00030,ko00230,ko01100,map00030,map00230,map01100 R00185,R01051,R02750 RC00002,RC00017 ko00000,ko00001,ko01000 iAF987.Gmet_2683 Bacteria 2GKBG@201174,COG0524@1,COG0524@2 NA|NA|NA G Ribokinase KOPIJCMJ_00291 1463855.JOHV01000002_gene2392 1e-49 202.6 Actinobacteria erpA GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009061,GO:0009987,GO:0010467,GO:0015980,GO:0016020,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055114,GO:0071704,GO:0071840,GO:0071944,GO:1901564 ko:K13628,ko:K15724 ko00000,ko03016 Bacteria 2IHR0@201174,COG0316@1,COG0316@2 NA|NA|NA S Belongs to the HesB IscA family KOPIJCMJ_00292 1048339.KB913029_gene4641 9.2e-85 320.9 Frankiales glxK GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 2.7.1.165 ko:K00865 ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130 R08572 RC00002,RC00428 ko00000,ko00001,ko01000 Bacteria 2GKHX@201174,4ERQR@85013,COG1929@1,COG1929@2 NA|NA|NA G Belongs to the glycerate kinase type-1 family KOPIJCMJ_00293 512565.AMIS_14080 5.9e-174 617.1 Micromonosporales nadA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 Bacteria 2GM59@201174,4D97S@85008,COG0379@1,COG0379@2 NA|NA|NA H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate KOPIJCMJ_00294 561175.KB894094_gene1456 8.1e-65 253.4 Streptosporangiales Bacteria 2GP15@201174,31PZA@2,4EIMY@85012,arCOG04740@1 NA|NA|NA KOPIJCMJ_00295 749414.SBI_05309 1.2e-102 379.8 Actinobacteria htpX ko:K03799 M00743 ko00000,ko00002,ko01000,ko01002 Bacteria 2GMJF@201174,COG0501@1,COG0501@2 NA|NA|NA O Belongs to the peptidase M48B family KOPIJCMJ_00296 1032480.MLP_42080 1.1e-67 263.5 Propionibacteriales pspA ko:K03969 ko00000 Bacteria 2GP0K@201174,4DPJS@85009,COG1842@1,COG1842@2 NA|NA|NA KT PspA/IM30 family KOPIJCMJ_00297 1303692.SFUL_1738 6.9e-32 144.1 Actinobacteria GO:0008150,GO:0009605,GO:0009607,GO:0020012,GO:0030682,GO:0042783,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0075136 Bacteria 2AN86@1,2HWWU@201174,31D67@2 NA|NA|NA S membrane KOPIJCMJ_00298 469371.Tbis_1278 5.1e-139 500.7 Pseudonocardiales GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0004033,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0008076,GO:0008150,GO:0008152,GO:0009117,GO:0009898,GO:0009987,GO:0010959,GO:0012505,GO:0012506,GO:0015459,GO:0016020,GO:0016021,GO:0016192,GO:0016247,GO:0016491,GO:0016614,GO:0016616,GO:0019362,GO:0019637,GO:0019897,GO:0019898,GO:0030141,GO:0030424,GO:0030659,GO:0030667,GO:0031090,GO:0031224,GO:0031226,GO:0031234,GO:0031410,GO:0031982,GO:0032879,GO:0032880,GO:0032940,GO:0032991,GO:0033267,GO:0034641,GO:0034702,GO:0034703,GO:0034705,GO:0034762,GO:0034765,GO:0035579,GO:0036230,GO:0042119,GO:0042581,GO:0042995,GO:0043005,GO:0043226,GO:0043227,GO:0043229,GO:0043266,GO:0043269,GO:0043299,GO:0043312,GO:0044224,GO:0044237,GO:0044238,GO:0044281,GO:0044304,GO:0044422,GO:0044424,GO:0044425,GO:0044433,GO:0044444,GO:0044446,GO:0044459,GO:0044463,GO:0044464,GO:0045055,GO:0045321,GO:0046483,GO:0046496,GO:0046903,GO:0050789,GO:0050794,GO:0050896,GO:0051049,GO:0051179,GO:0051186,GO:0051234,GO:0055086,GO:0055114,GO:0060341,GO:0065007,GO:0065009,GO:0070820,GO:0070821,GO:0070995,GO:0071704,GO:0071944,GO:0072524,GO:0097458,GO:0097708,GO:0098552,GO:0098562,GO:0098588,GO:0098772,GO:0098796,GO:0098797,GO:0098805,GO:0099106,GO:0099503,GO:0120025,GO:0120038,GO:1901360,GO:1901379,GO:1901564,GO:1902495,GO:1903827,GO:1904062,GO:1990031,GO:1990351,GO:2000008 Bacteria 2GMT5@201174,4DX8D@85010,COG0667@1,COG0667@2 NA|NA|NA C aldo keto reductase KOPIJCMJ_00299 981369.JQMJ01000004_gene2066 7.6e-16 89.4 Streptacidiphilus Bacteria 2EFWK@1,2IQXQ@201174,2NK0Q@228398,339NW@2 NA|NA|NA KOPIJCMJ_00300 1449355.JQNR01000003_gene515 1.1e-26 127.1 Actinobacteria Bacteria 2E883@1,2I8J4@201174,332M6@2 NA|NA|NA KOPIJCMJ_00301 1120950.KB892707_gene4769 3.8e-74 285.4 Propionibacteriales ecfT GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015238,GO:0015711,GO:0015893,GO:0016020,GO:0022857,GO:0032217,GO:0032218,GO:0034220,GO:0035461,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051180,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0090482,GO:0098656 ko:K02008,ko:K16783,ko:K16785 ko02010,map02010 M00245,M00246,M00581,M00582 ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23,3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 Bacteria 2GKHK@201174,4DPHW@85009,COG0619@1,COG0619@2 NA|NA|NA P Cobalt transport protein KOPIJCMJ_00302 479435.Kfla_2709 2.6e-188 665.2 Propionibacteriales ko:K16786,ko:K16787 ko02010,map02010 M00582 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 Bacteria 2I2Y2@201174,4DP2H@85009,COG3845@1,COG3845@2 NA|NA|NA S AAA domain, putative AbiEii toxin, Type IV TA system KOPIJCMJ_00303 1463864.JOGO01000009_gene499 3.8e-66 258.5 Actinobacteria ko:K02006,ko:K16784,ko:K16786,ko:K16787,ko:K16927 ko02010,map02010 M00245,M00246,M00581,M00582 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.18,3.A.1.22,3.A.1.23,3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 Bacteria 2GMK1@201174,COG1122@1,COG1122@2 NA|NA|NA P ECF transporter, substrate-specific component KOPIJCMJ_00304 1078020.KEK_15608 2.5e-99 369.4 Mycobacteriaceae cobU 2.7.1.156,2.7.7.62 ko:K02231 ko00860,ko01100,map00860,map01100 M00122 R05221,R05222,R06558 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 Bacteria 23984@1762,2GM8Q@201174,COG1235@1,COG1235@2,COG2087@1,COG2087@2 NA|NA|NA H cobinamide kinase KOPIJCMJ_00305 446462.Amir_1358 8.7e-100 370.5 Pseudonocardiales cobT 2.4.2.21 ko:K00768 ko00860,ko01100,map00860,map01100 M00122 R04148 RC00033,RC00063 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv2207 Bacteria 2GJ16@201174,4DX78@85010,COG2038@1,COG2038@2 NA|NA|NA H Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) KOPIJCMJ_00306 469371.Tbis_1275 3.1e-35 155.6 Pseudonocardiales cobS GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008818,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.8.26 ko:K02233 ko00860,ko01100,map00860,map01100 M00122 R05223,R11174 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKM4@201174,4E2M6@85010,COG0368@1,COG0368@2 NA|NA|NA H Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate KOPIJCMJ_00307 2074.JNYD01000003_gene3655 1.1e-107 396.7 Pseudonocardiales gcvT GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ47@201174,4DXZ6@85010,COG0404@1,COG0404@2 NA|NA|NA E The glycine cleavage system catalyzes the degradation of glycine KOPIJCMJ_00308 266940.Krad_3276 1e-127 463.8 Actinobacteria pepA GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 Bacteria 2GJRB@201174,COG0260@1,COG0260@2 NA|NA|NA E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides KOPIJCMJ_00309 65497.JODV01000003_gene4511 8.7e-198 696.4 Pseudonocardiales lpdA 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GIXY@201174,4DZEU@85010,COG1249@1,COG1249@2 NA|NA|NA C TIGRFAM Dihydrolipoamide dehydrogenase KOPIJCMJ_00311 593907.Celgi_2847 9e-139 500.0 Cellulomonadaceae asd GO:0003674,GO:0003824,GO:0004073,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv3708c Bacteria 2GJJ8@201174,4F0DR@85016,COG0136@1,COG0136@2 NA|NA|NA E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate KOPIJCMJ_00312 479432.Sros_9311 2e-167 595.5 Streptosporangiales ask 1.1.1.3,2.7.2.4 ko:K00928,ko:K12524 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480,R01773,R01775 RC00002,RC00043,RC00087 ko00000,ko00001,ko00002,ko01000 Bacteria 2GN0G@201174,4EG8Z@85012,COG0527@1,COG0527@2 NA|NA|NA E ACT domain KOPIJCMJ_00313 44060.JODL01000011_gene1967 3.4e-42 178.3 Actinobacteria Bacteria 299JI@1,2GMZP@201174,2ZWN1@2 NA|NA|NA S Domain of unknown function (DUF5063) KOPIJCMJ_00314 1120936.KB907212_gene5028 5.5e-88 330.5 Streptosporangiales recR GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 ko:K06187 ko03440,map03440 ko00000,ko00001,ko03400 Bacteria 2GJY0@201174,4EG4M@85012,COG0353@1,COG0353@2 NA|NA|NA L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO KOPIJCMJ_00317 1380354.JIAN01000008_gene3362 5.4e-44 184.9 Actinobacteria 3.2.1.91 ko:K19668 ko00500,ko01100,ko02020,map00500,map01100,map02020 R02886,R11308 RC00799 ko00000,ko00001,ko01000 GH6 Bacteria 2GN7G@201174,COG3291@1,COG3291@2,COG3420@1,COG3420@2 NA|NA|NA P PFAM PKD domain containing protein KOPIJCMJ_00318 1121924.ATWH01000001_gene4304 1.2e-118 433.7 Microbacteriaceae gumJ ko:K03328 ko00000 2.A.66.2 Bacteria 2H55P@201174,4FM0V@85023,COG2244@1,COG2244@2 NA|NA|NA M Polysaccharide biosynthesis protein KOPIJCMJ_00319 590998.Celf_3032 2.3e-92 346.3 Cellulomonadaceae wcoI 2.7.10.2 ko:K08253,ko:K16692 ko00000,ko01000,ko01001 Bacteria 2GJ1Y@201174,4F2TG@85016,COG0489@1,COG0489@2,COG3944@1,COG3944@2 NA|NA|NA M PFAM lipopolysaccharide biosynthesis protein KOPIJCMJ_00320 1150399.AQYK01000002_gene3211 1.6e-71 276.9 Microbacteriaceae Bacteria 2CD7Z@1,2GNGQ@201174,30EQS@2,4FNRW@85023 NA|NA|NA KOPIJCMJ_00321 134676.ACPL_4271 3.5e-60 237.7 Actinobacteria Bacteria 2IK0B@201174,COG4275@1,COG4275@2 NA|NA|NA S chromate resistance protein KOPIJCMJ_00322 591159.ACEZ01000200_gene2508 5.6e-37 160.6 Actinobacteria chrB Bacteria 2IPJU@201174,COG4275@1,COG4275@2 NA|NA|NA S Chromate resistance exported protein KOPIJCMJ_00323 1385520.N802_11095 4e-87 327.8 Actinobacteria Bacteria 2AAWD@1,2IG0D@201174,3109H@2 NA|NA|NA S Alkylmercury lyase KOPIJCMJ_00324 55952.BU52_23640 2.5e-36 157.9 Bacteria nirK 1.7.2.1 ko:K00368 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 Bacteria COG2132@1,COG2132@2 NA|NA|NA Q Multicopper oxidase KOPIJCMJ_00326 1312959.KI914644_gene993 4.4e-09 67.4 Micrococcaceae ko:K11069 ko02010,map02010 M00299 ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 Bacteria 1WAGE@1268,2GKVG@201174,COG0687@1,COG0687@2 NA|NA|NA E Bacterial extracellular solute-binding protein KOPIJCMJ_00327 446465.Bfae_04580 5.6e-68 265.0 Actinobacteria Bacteria 2GJ3V@201174,COG2801@1,COG2801@2 NA|NA|NA L Transposase KOPIJCMJ_00329 1094980.Mpsy_0339 3e-14 84.7 Methanomicrobia ko:K10716 ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 Archaea 2NA44@224756,2Y1ZP@28890,COG1226@1,arCOG01958@2157 NA|NA|NA P Ion channel KOPIJCMJ_00330 318424.EU78_15100 2.3e-22 112.1 Bacteria 2.3.1.82 ko:K18815 br01600,ko00000,ko01000,ko01504 Bacteria COG0454@1,COG0456@2 NA|NA|NA K acetyltransferase KOPIJCMJ_00331 1254432.SCE1572_28415 1.6e-33 149.4 Proteobacteria betI9 Bacteria 1N6TK@1224,COG1309@1,COG1309@2 NA|NA|NA K Transcriptional regulator KOPIJCMJ_00333 1108045.GORHZ_053_00570 4.5e-64 251.5 Gordoniaceae vdlC Bacteria 2IIVW@201174,4GE8H@85026,COG0300@1,COG0300@2 NA|NA|NA S NAD(P)H-binding KOPIJCMJ_00334 47839.CCAU010000011_gene5295 1.7e-20 106.3 Mycobacteriaceae Bacteria 2391H@1762,2IMN5@201174,COG1309@1,COG1309@2 NA|NA|NA K WHG domain KOPIJCMJ_00335 436229.JOEH01000019_gene6518 2.2e-31 142.1 Streptacidiphilus Bacteria 2GP92@201174,2NI6N@228398,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family KOPIJCMJ_00336 935866.JAER01000042_gene2745 7.3e-46 190.7 Propionibacteriales Bacteria 2GIWB@201174,4DPT1@85009,COG0741@1,COG0741@2,COG0791@1,COG0791@2 NA|NA|NA M NlpC/P60 family KOPIJCMJ_00337 935866.JAER01000042_gene2744 6.6e-14 84.0 Propionibacteriales Bacteria 2B1ES@1,2GT2Q@201174,31TVG@2,4DSCJ@85009 NA|NA|NA S Flagellar FliJ protein KOPIJCMJ_00338 397278.JOJN01000001_gene2897 1.5e-170 605.9 Propionibacteriales fliI GO:0003674,GO:0005488,GO:0005515,GO:0042802 3.6.3.14 ko:K02412,ko:K03224 ko02040,ko03070,map02040,map03070 M00332,M00542,M00660 ko00000,ko00001,ko00002,ko01000,ko02035,ko02044 3.A.6.1,3.A.6.2,3.A.6.3 Bacteria 2GKGV@201174,4DPDQ@85009,COG1157@1,COG1157@2 NA|NA|NA NU ATP synthase alpha/beta family, nucleotide-binding domain KOPIJCMJ_00339 1380356.JNIK01000011_gene1564 8.8e-15 86.3 Frankiales fliH ko:K02411,ko:K03223 ko02040,ko03070,map02040,map03070 M00332,M00660 ko00000,ko00001,ko00002,ko02035,ko02044 3.A.6.1,3.A.6.2,3.A.6.3 Bacteria 2IRIT@201174,4ETDH@85013,COG1317@1,COG1317@2 NA|NA|NA N Flagellar assembly protein FliH KOPIJCMJ_00341 58123.JOFJ01000012_gene5428 2.4e-41 176.0 Streptosporangiales apbE 2.7.1.180 ko:K03734 ko00000,ko01000 Bacteria 2GN6F@201174,4EPRS@85012,COG1477@1,COG1477@2 NA|NA|NA H ApbE family KOPIJCMJ_00343 1214101.BN159_1336 6.7e-07 61.2 Actinobacteria Bacteria 2GTTI@201174,COG3976@1,COG3976@2 NA|NA|NA S FMN-binding domain protein KOPIJCMJ_00345 1121017.AUFG01000022_gene2176 5.5e-95 354.4 Intrasporangiaceae fieF Bacteria 2GJ8Q@201174,4FE8E@85021,COG0053@1,COG0053@2 NA|NA|NA P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family KOPIJCMJ_00346 1121926.AXWO01000005_gene411 1.7e-20 105.5 Actinobacteria ko:K03892 ko00000,ko03000 Bacteria 2IRF0@201174,COG0640@1,COG0640@2 NA|NA|NA K helix_turn_helix, Arsenical Resistance Operon Repressor KOPIJCMJ_00348 58123.JOFJ01000012_gene5412 1.4e-101 376.3 Streptosporangiales ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GKEH@201174,4ENNZ@85012,COG1131@1,COG1131@2 NA|NA|NA V AAA domain, putative AbiEii toxin, Type IV TA system KOPIJCMJ_00349 58123.JOFJ01000012_gene5413 1.8e-112 413.3 Streptosporangiales ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GMSI@201174,4EPCM@85012,COG3559@1,COG3559@2 NA|NA|NA M Exporter of polyketide KOPIJCMJ_00350 710421.Mycch_2936 1.3e-102 379.8 Mycobacteriaceae ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 23350@1762,2GKEH@201174,COG1131@1,COG1131@2 NA|NA|NA V ABC transporter KOPIJCMJ_00351 710421.Mycch_2937 2.3e-115 422.9 Bacteria ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria COG3559@1,COG3559@2 NA|NA|NA M Exporter of polyketide antibiotics KOPIJCMJ_00352 324925.Ppha_0345 1.3e-15 89.7 Bacteria Bacteria COG2020@1,COG2020@2 NA|NA|NA O methyltransferase activity KOPIJCMJ_00353 1304865.JAGF01000001_gene2616 5.7e-87 327.0 Actinobacteria Bacteria 2GKX0@201174,COG0262@1,COG0262@2 NA|NA|NA H bifunctional deaminase-reductase domain protein KOPIJCMJ_00355 1385519.N801_06575 1.2e-172 612.8 Intrasporangiaceae Bacteria 2GJE2@201174,4FHMX@85021,COG3103@1,COG4991@2 NA|NA|NA T Peptidoglycan-binding protein KOPIJCMJ_00358 1121372.AULK01000001_gene1922 3e-78 298.5 Microbacteriaceae Bacteria 2GJUE@201174,4FPKA@85023,COG2267@1,COG2267@2 NA|NA|NA I Alpha/beta hydrolase family KOPIJCMJ_00359 1298863.AUEP01000017_gene4145 1.3e-147 530.0 Propionibacteriales sulP GO:0003333,GO:0003674,GO:0005215,GO:0005310,GO:0005326,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0008272,GO:0008509,GO:0008514,GO:0015075,GO:0015103,GO:0015116,GO:0015138,GO:0015141,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015238,GO:0015318,GO:0015556,GO:0015698,GO:0015711,GO:0015740,GO:0015741,GO:0015744,GO:0015800,GO:0015807,GO:0015810,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070778,GO:0071422,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0098656,GO:0098660,GO:0098661,GO:1901682,GO:1902358,GO:1902475,GO:1903825,GO:1905039 ko:K03321 ko00000,ko02000 2.A.53.3 iSbBS512_1146.SbBS512_E1370 Bacteria 2GJCB@201174,4DNAM@85009,COG0659@1,COG0659@2 NA|NA|NA P Sulfate permease family KOPIJCMJ_00360 1298863.AUEP01000017_gene4144 8.8e-32 142.9 Propionibacteriales arsR9 ko:K03892 ko00000,ko03000 Bacteria 2IKK2@201174,4DRX6@85009,COG0640@1,COG0640@2 NA|NA|NA K helix_turn_helix, Arsenical Resistance Operon Repressor KOPIJCMJ_00361 1001240.GY21_03890 7.9e-163 580.5 Microbacteriaceae hycE ko:K14089 ko00000 Bacteria 2GYM5@201174,4FSFF@85023,COG3261@1,COG3261@2,COG3262@1,COG3262@2 NA|NA|NA C Respiratory-chain NADH dehydrogenase, 49 Kd subunit KOPIJCMJ_00362 196162.Noca_4466 3.7e-138 498.4 Propionibacteriales hyfF ko:K12141 ko00000,ko01000 Bacteria 2HAC7@201174,4DTN6@85009,COG0651@1,COG0651@2 NA|NA|NA CP Proton-conducting membrane transporter KOPIJCMJ_00363 1001240.GY21_03900 8.6e-45 187.2 Microbacteriaceae hyfE GO:0008150,GO:0040007 ko:K12140 ko00000,ko01000 Bacteria 2HQ3P@201174,4FQSR@85023,COG4237@1,COG4237@2 NA|NA|NA C Hydrogenase 4 membrane KOPIJCMJ_00364 1001240.GY21_03905 1.5e-95 356.3 Microbacteriaceae hycD Bacteria 2GJFM@201174,4FPM3@85023,COG0650@1,COG0650@2 NA|NA|NA C NADH dehydrogenase KOPIJCMJ_00365 196162.Noca_4469 4.4e-190 671.4 Propionibacteriales hyfB Bacteria 2HAC7@201174,4DSYG@85009,COG0651@1,COG0651@2 NA|NA|NA CP Proton-conducting membrane transporter KOPIJCMJ_00366 196162.Noca_4470 4.6e-59 234.2 Propionibacteriales hycG Bacteria 2IDTD@201174,4DUTR@85009,COG3260@1,COG3260@2 NA|NA|NA C NADH ubiquinone oxidoreductase, 20 Kd subunit KOPIJCMJ_00367 590998.Celf_2528 2.7e-108 399.1 Cellulomonadaceae Bacteria 2GJEG@201174,4F1NE@85016,COG4585@1,COG4585@2 NA|NA|NA T PFAM histidine kinase dimerisation and phosphoacceptor region KOPIJCMJ_00368 590998.Celf_2529 3.8e-92 344.7 Cellulomonadaceae tcsR2 Bacteria 2GJ46@201174,4F1QA@85016,COG2197@1,COG2197@2 NA|NA|NA T PFAM response regulator receiver KOPIJCMJ_00369 1454010.JEOE01000003_gene259 9e-107 393.3 Actinobacteria ko:K02003 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GJN6@201174,COG1136@1,COG1136@2 NA|NA|NA V ABC transporter KOPIJCMJ_00370 593907.Celgi_1060 2.2e-170 606.3 Cellulomonadaceae ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 2H37M@201174,4F1Y9@85016,COG3127@1,COG3127@2 NA|NA|NA Q MacB-like periplasmic core domain KOPIJCMJ_00371 1121017.AUFG01000012_gene1807 6.4e-206 723.8 Intrasporangiaceae malS GO:0003674,GO:0003824,GO:0004470,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006090,GO:0006108,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016614,GO:0016615,GO:0019752,GO:0032787,GO:0043436,GO:0043648,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071704 1.1.1.38 ko:K00027 ko00620,ko01200,ko02020,map00620,map01200,map02020 R00214 RC00105 ko00000,ko00001,ko01000 Bacteria 2GJAJ@201174,4FG5T@85021,COG0281@1,COG0281@2 NA|NA|NA C Malic enzyme, NAD binding domain KOPIJCMJ_00372 443218.AS9A_2146 1.5e-50 205.7 Actinobacteria Bacteria 2CAJE@1,2IMDF@201174,33XCP@2 NA|NA|NA KOPIJCMJ_00373 590998.Celf_0701 1.2e-16 92.8 Bacteria cbpA 2.4.1.333 ko:K21298 ko00000,ko01000 GH94 Bacteria COG3459@1,COG3459@2 NA|NA|NA G carbohydrate binding KOPIJCMJ_00374 266940.Krad_3698 3.1e-50 206.5 Actinobacteria 2.7.13.3,3.1.3.3 ko:K07315,ko:K07654,ko:K07675 ko02020,map02020 M00461,M00473 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko03021 Bacteria 2IHH3@201174,COG2208@1,COG2208@2,COG3850@1,COG3850@2 NA|NA|NA KT stage II sporulation KOPIJCMJ_00375 742722.HMPREF9463_00308 1.4e-113 417.2 Coriobacteriia ko:K06147,ko:K12531 ko02020,map02020 M00326 ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 2I6AF@201174,4CUQX@84998,COG5265@1,COG5265@2 NA|NA|NA O ABC transporter KOPIJCMJ_00376 767434.Fraau_3109 2.3e-49 201.8 Xanthomonadales trmL GO:0001510,GO:0002128,GO:0002130,GO:0002131,GO:0002132,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.207 ko:K03216 ko00000,ko01000,ko03016 Bacteria 1RCY4@1224,1S3PI@1236,1X643@135614,COG0219@1,COG0219@2 NA|NA|NA J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide KOPIJCMJ_00377 743718.Isova_0180 2.2e-70 272.3 Promicromonosporaceae tipA ko:K21744 ko00000,ko03000 Bacteria 2H5GI@201174,4F45E@85017,COG0789@1,COG0789@2 NA|NA|NA K TipAS antibiotic-recognition domain KOPIJCMJ_00378 1463881.KL591002_gene4566 6.4e-28 131.0 Bacteria yahN GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015318,GO:0015711,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1903825,GO:1905039 ko:K03329,ko:K16327 ko00000,ko02000 2.A.76.1.3,2.A.76.1.6 Bacteria COG1280@1,COG1280@2 NA|NA|NA E homoserine transmembrane transporter activity KOPIJCMJ_00379 266940.Krad_3445 3.4e-96 358.2 Actinobacteria aroE GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 Bacteria 2GPXV@201174,COG0169@1,COG0169@2 NA|NA|NA E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) KOPIJCMJ_00381 1136417.AZWE01000022_gene2611 1.1e-31 143.3 Micromonosporales Bacteria 2ENA9@1,2IS82@201174,33FXZ@2,4DF28@85008 NA|NA|NA KOPIJCMJ_00382 1123023.JIAI01000001_gene6982 2.3e-08 65.5 Pseudonocardiales ko:K06893 ko00000 Bacteria 2HPCK@201174,4E7Y5@85010,COG5485@1,COG5485@2 NA|NA|NA S SnoaL-like polyketide cyclase KOPIJCMJ_00383 1380370.JIBA01000012_gene3687 4.8e-30 136.7 Actinobacteria Bacteria 2EAYY@1,2I2ZT@201174,334ZV@2 NA|NA|NA S Protein of unknown function (DUF4242) KOPIJCMJ_00384 1283299.AUKG01000005_gene135 1.4e-12 81.6 Rubrobacteria Bacteria 2I4C3@201174,4CQSU@84995,COG0823@1,COG0823@2 NA|NA|NA U Involved in the tonB-independent uptake of proteins KOPIJCMJ_00385 512565.AMIS_64340 8.3e-09 66.2 Micromonosporales Bacteria 2CIG4@1,2HUTV@201174,33C84@2,4DFZJ@85008 NA|NA|NA KOPIJCMJ_00387 1463936.JOJI01000077_gene65 2.3e-24 118.6 Actinobacteria Bacteria 2IBP1@201174,COG2207@1,COG2207@2 NA|NA|NA K transcriptional regulator KOPIJCMJ_00388 1463934.JOCF01000050_gene7607 3.5e-14 86.3 Actinobacteria 2.1.1.107 ko:K02303,ko:K22010 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121,M00839 R03194 RC00003,RC00871 ko00000,ko00001,ko00002,ko01000,ko02022 Bacteria 2H0E2@201174,COG2203@1,COG2203@2,COG3707@1,COG3707@2 NA|NA|NA T ANTAR KOPIJCMJ_00389 593907.Celgi_2056 5.5e-32 144.4 Actinobacteria Bacteria 2GIZF@201174,COG5001@1,COG5001@2 NA|NA|NA T signal transduction protein containing a membrane domain an EAL and a GGDEF domain KOPIJCMJ_00390 479435.Kfla_1567 1.1e-83 317.0 Propionibacteriales tagH 3.6.3.38,3.6.3.40 ko:K09689,ko:K09691,ko:K09693 ko02010,map02010 M00249,M00250,M00251 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.101,3.A.1.103,3.A.1.104 Bacteria 2GIVF@201174,4DPY7@85009,COG1134@1,COG1134@2 NA|NA|NA GM ATPases associated with a variety of cellular activities KOPIJCMJ_00391 2002.JOEQ01000052_gene8351 7.1e-76 290.8 Streptosporangiales tagG ko:K09690,ko:K09692 ko02010,map02010 M00250,M00251 ko00000,ko00001,ko00002,ko02000 3.A.1.103,3.A.1.104 Bacteria 2GP5K@201174,4EHWE@85012,COG1682@1,COG1682@2 NA|NA|NA GM ABC-2 type transporter KOPIJCMJ_00392 1123320.KB889719_gene7401 3.9e-127 461.5 Actinobacteria purK GO:0000166,GO:0003674,GO:0003824,GO:0004638,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016829,GO:0016830,GO:0016831,GO:0016874,GO:0016879,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034028,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.4.18 ko:K01589 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07404 RC01927 ko00000,ko00001,ko00002,ko01000 iECUMN_1333.ECUMN_0562,iYL1228.KPN_00477 Bacteria 2GJCU@201174,COG0026@1,COG0026@2 NA|NA|NA F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) KOPIJCMJ_00393 1123322.KB904693_gene4560 2.6e-26 124.4 Actinobacteria rpoC GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 Bacteria 2GKWF@201174,COG0086@1,COG0086@2 NA|NA|NA K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates KOPIJCMJ_00395 196162.Noca_3925 1.3e-58 232.3 Propionibacteriales rpsL GO:0000372,GO:0000375,GO:0000376,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008380,GO:0009058,GO:0009059,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010604,GO:0010628,GO:0015935,GO:0016070,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0031323,GO:0031325,GO:0032991,GO:0033120,GO:0034336,GO:0034337,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043484,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990145,GO:1990904 ko:K02950 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IHUF@201174,4DQR6@85009,COG0048@1,COG0048@2 NA|NA|NA J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit KOPIJCMJ_00397 478801.Ksed_24140 1.6e-72 280.0 Dermacoccaceae menC GO:0008150,GO:0040007 4.2.1.113,5.1.1.20,5.1.1.3 ko:K01776,ko:K02549,ko:K19802 ko00130,ko00471,ko01100,ko01110,map00130,map00471,map01100,map01110 M00116 R00260,R04031,R10938 RC00302,RC01053,RC03309 ko00000,ko00001,ko00002,ko01000,ko01011 iNJ661.Rv0553,iSB619.SA_RS09080 Bacteria 1ZVR3@145357,2GJJR@201174,COG4948@1,COG4948@2 NA|NA|NA H Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) KOPIJCMJ_00398 65497.JODV01000007_gene534 7.5e-129 466.8 Pseudonocardiales menB GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0008150,GO:0008152,GO:0008935,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0042180,GO:0042181,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:0071890,GO:1901576,GO:1901661,GO:1901663 4.1.3.36 ko:K01661 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R07263 RC01923 ko00000,ko00001,ko00002,ko01000 iJN678.menB,iYL1228.KPN_02660 Bacteria 2GK5G@201174,4E09A@85010,COG0447@1,COG0447@2 NA|NA|NA H Belongs to the enoyl-CoA hydratase isomerase family. MenB subfamily KOPIJCMJ_00399 67373.JOBF01000006_gene2459 2.4e-36 159.1 Actinobacteria Bacteria 2GP92@201174,COG1309@1,COG1309@2 NA|NA|NA K transcriptional regulator KOPIJCMJ_00400 1254432.SCE1572_32985 1.9e-21 110.5 Proteobacteria Bacteria 1N5ID@1224,COG3591@1,COG3591@2 NA|NA|NA E Belongs to the peptidase S1B family KOPIJCMJ_00401 1120950.KB892720_gene1909 1.8e-100 372.9 Propionibacteriales nagA 3.5.1.25 ko:K01443 ko00520,ko01130,map00520,map01130 R02059 RC00166,RC00300 ko00000,ko00001,ko01000 iNJ661.Rv3332 Bacteria 2GK1E@201174,4DPBF@85009,COG1820@1,COG1820@2 NA|NA|NA G Belongs to the metallo-dependent hydrolases superfamily. NagA family KOPIJCMJ_00402 700508.D174_09895 7.6e-142 510.8 Mycobacteriaceae nagE 2.7.1.193,2.7.1.199 ko:K02802,ko:K02803,ko:K02804,ko:K20116,ko:K20117,ko:K20118 ko00010,ko00520,ko02060,map00010,map00520,map02060 M00267,M00809 R02738,R05199 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.13,4.A.1.1.14,4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7,4.A.1.1.9 Bacteria 235ZF@1762,2GKPM@201174,COG1263@1,COG1263@2,COG1264@1,COG1264@2 NA|NA|NA G phosphotransferase system, EIIB KOPIJCMJ_00404 1150599.MPHLEI_21374 1.9e-43 181.8 Mycobacteriaceae fkb 5.2.1.8 ko:K01802,ko:K03772 ko00000,ko01000,ko03110 Bacteria 239F5@1762,2IHQC@201174,COG0545@1,COG0545@2 NA|NA|NA O Peptidyl-prolyl cis-trans isomerase KOPIJCMJ_00405 1229780.BN381_350110 1.5e-27 129.8 unclassified Actinobacteria (class) Bacteria 2IHQC@201174,3UWVE@52018,COG0545@1,COG0545@2 NA|NA|NA O FKBP-type peptidyl-prolyl cis-trans isomerase KOPIJCMJ_00406 1123320.KB889667_gene2950 1.1e-197 696.0 Actinobacteria pafA GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170 6.3.1.19 ko:K13571 M00342 R11207 RC00090,RC00096 ko00000,ko00002,ko01000,ko03051 Bacteria 2GMC6@201174,COG0638@1,COG0638@2 NA|NA|NA O Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine KOPIJCMJ_00407 1184609.KILIM_006_00080 1.1e-79 303.1 Dermatophilaceae prcA GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019773,GO:0019941,GO:0030163,GO:0030312,GO:0032991,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 ko:K03432 ko03050,map03050 M00342,M00343 ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 Bacteria 2GKZ1@201174,4F6S2@85018,COG0638@1,COG0638@2 NA|NA|NA O Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation KOPIJCMJ_00408 479435.Kfla_3226 6.5e-95 354.0 Propionibacteriales prcB GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019774,GO:0019899,GO:0019941,GO:0030163,GO:0032991,GO:0035375,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 ko:K03433 ko03050,map03050 M00342,M00343 ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 Bacteria 2GJ60@201174,4DPD6@85009,COG0638@1,COG0638@2 NA|NA|NA O Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation KOPIJCMJ_00409 446466.Cfla_2002 1e-09 68.9 Cellulomonadaceae pup GO:0003674,GO:0005488,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0031386,GO:0032446,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044877,GO:0051603,GO:0070490,GO:0070628,GO:0070647,GO:0071704,GO:1901564,GO:1901565,GO:1901575 ko:K13570 ko00000,ko04121 Bacteria 2E9C2@1,2I1D6@201174,333JS@2,4F1MQ@85016 NA|NA|NA S Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation KOPIJCMJ_00410 469371.Tbis_1836 3.3e-166 591.7 Pseudonocardiales dop GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.5.1.119,6.3.1.19 ko:K13571,ko:K20814 M00342 R11207 RC00090,RC00096 ko00000,ko00002,ko01000,ko03051 Bacteria 2GJGI@201174,4DZ25@85010,COG4122@1,COG4122@2 NA|NA|NA S proteasome accessory factor PafA2 KOPIJCMJ_00411 1205680.CAKO01000002_gene2132 4.3e-20 104.4 Rhodospirillales Bacteria 1MZR5@1224,2JU1E@204441,2UCIB@28211,COG3339@1,COG3339@2 NA|NA|NA S Protein of unknown function (DUF1232) KOPIJCMJ_00412 103733.JNYO01000021_gene6755 7.5e-30 137.9 Actinobacteria Bacteria 2H3FK@201174,COG2199@1,COG3706@2,COG5001@1,COG5001@2 NA|NA|NA T diguanylate cyclase KOPIJCMJ_00413 1416759.AYMR01000024_gene2577 1.9e-196 691.8 Microbacteriaceae uvrA2 Bacteria 2GJUV@201174,4FM29@85023,COG0178@1,COG0178@2 NA|NA|NA L ABC transporter KOPIJCMJ_00414 1394178.AWOO02000044_gene4467 2.4e-40 172.9 Streptosporangiales pafC GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 ko:K13573 ko00000,ko03051 Bacteria 2GMAU@201174,4EG4Y@85012,COG2378@1,COG2378@2 NA|NA|NA K WYL domain KOPIJCMJ_00415 266940.Krad_1881 1.4e-16 92.4 Actinobacteria Bacteria 2BZPH@1,2IQ4A@201174,33EX8@2 NA|NA|NA KOPIJCMJ_00416 106370.Francci3_2305 6.1e-12 76.6 Frankiales tatA ko:K03116 ko03060,ko03070,map03060,map03070 M00336 ko00000,ko00001,ko00002,ko02044 2.A.64 Bacteria 2GQQX@201174,4ETM8@85013,COG1826@1,COG1826@2 NA|NA|NA U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system KOPIJCMJ_00417 1504319.GM45_0890 2.8e-63 248.8 unclassified Actinobacteria (class) tatC GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 ko:K03118 ko03060,ko03070,map03060,map03070 M00336 ko00000,ko00001,ko00002,ko02044 2.A.64 Bacteria 2GJK8@201174,3UWSI@52018,COG0805@1,COG0805@2 NA|NA|NA U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides KOPIJCMJ_00418 1121272.KB903257_gene5486 3.3e-65 255.4 Micromonosporales dagK GO:0003674,GO:0003824,GO:0004143,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.1.107 ko:K07029 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 R02240 RC00002,RC00017 ko00000,ko00001,ko01000 Bacteria 2GK3P@201174,4D9SI@85008,COG1597@1,COG1597@2 NA|NA|NA I Diacylglycerol kinase KOPIJCMJ_00419 1123322.KB904647_gene1742 6.3e-301 1040.0 Actinobacteria helY GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575 ko:K03727 ko00000,ko01000 Bacteria 2GJEX@201174,COG4581@1,COG4581@2 NA|NA|NA L DEAD DEAH box helicase KOPIJCMJ_00421 266940.Krad_1887 4.1e-87 328.2 Actinobacteria polA GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 Bacteria 2GKTZ@201174,COG0258@1,COG0258@2 NA|NA|NA L 5'-3' exonuclease KOPIJCMJ_00422 436229.JOEH01000002_gene3343 2.4e-132 478.8 Streptacidiphilus acdA ko:K18244 ko00000,ko01000 Bacteria 2GIX8@201174,2NHRD@228398,COG1960@1,COG1960@2 NA|NA|NA I Acyl-CoA dehydrogenase, C-terminal domain KOPIJCMJ_00423 1896.JOAU01000013_gene1986 2.7e-52 211.5 Actinobacteria lrp_3 ko:K03719 ko00000,ko03000,ko03036 Bacteria 2GK3G@201174,COG1522@1,COG1522@2 NA|NA|NA K asnC family KOPIJCMJ_00424 1298863.AUEP01000008_gene1335 2.6e-197 694.9 Propionibacteriales kamA1 5.4.3.2 ko:K01843 ko00310,map00310 R00461 RC00303 ko00000,ko00001,ko01000 Bacteria 2GM2P@201174,4DP5B@85009,COG1509@1,COG1509@2 NA|NA|NA E lysine 2,3-aminomutase KOPIJCMJ_00425 219305.MCAG_00044 1.3e-124 453.0 Micromonosporales kdd 1.4.1.11 ko:K18012 ko00310,map00310 R03349 RC00888 ko00000,ko00001,ko01000 Bacteria 2GK3U@201174,4DA07@85008,COG1063@1,COG1063@2 NA|NA|NA E Dehydrogenase KOPIJCMJ_00426 1463856.JOHY01000016_gene5622 1e-152 547.0 Actinobacteria ytcJ Bacteria 2GJVW@201174,COG1574@1,COG1574@2 NA|NA|NA E amidohydrolase KOPIJCMJ_00427 1120950.KB892708_gene4481 1.2e-222 779.2 Propionibacteriales deoC GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 4.1.2.4,5.4.3.3 ko:K01619,ko:K01844 ko00030,ko00310,map00030,map00310 R01066,R02852,R03275 RC00436,RC00437,RC00719 ko00000,ko00001,ko01000 Bacteria 2GUM7@201174,4DNH2@85009,COG0274@1,COG0274@2 NA|NA|NA F D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit KOPIJCMJ_00428 1122609.AUGT01000003_gene2193 1.3e-94 352.8 Propionibacteriales kamE 5.4.3.3,5.4.3.5 ko:K17898,ko:K18011 ko00310,ko00472,map00310,map00472 R02461,R02852,R03275 RC00719 ko00000,ko00001,ko01000 Bacteria 2HF50@201174,4DNBN@85009,COG2185@1,COG2185@2 NA|NA|NA I Dimerisation domain of d-ornithine 4,5-aminomutase KOPIJCMJ_00429 1120934.KB894404_gene715 2e-44 185.3 Pseudonocardiales 4.3.1.14 ko:K18014 ko00310,map00310 R03030 RC00833 ko00000,ko00001,ko01000 Bacteria 2IKM2@201174,4E3PP@85010,COG1607@1,COG1607@2 NA|NA|NA I Thioesterase superfamily KOPIJCMJ_00430 561175.KB894096_gene668 8.6e-112 411.0 Streptosporangiales lnt ko:K03820 ko00000,ko01000 GT2 Bacteria 2GJ9F@201174,4EHTJ@85012,COG0815@1,COG0815@2 NA|NA|NA M Transfers the fatty acyl group on membrane lipoproteins KOPIJCMJ_00431 452652.KSE_45450 2.4e-97 362.1 Kitasatospora dpm1 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 R01009 RC00005 ko00000,ko00001,ko01000,ko01003 GT2 Bacteria 2I2FA@201174,2M0M1@2063,COG1216@1,COG1216@2 NA|NA|NA S Glycosyltransferase like family 2 KOPIJCMJ_00433 479433.Caci_5317 7.8e-34 149.8 Actinobacteria rbpA GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 Bacteria 2CNY9@1,2I80U@201174,31DSU@2 NA|NA|NA K RNA polymerase-binding protein KOPIJCMJ_00434 1288494.EBAPG3_12090 2.6e-15 89.7 Nitrosomonadales Bacteria 1PWB7@1224,2BTJW@1,2WBVY@28216,32NSK@2,373WE@32003 NA|NA|NA KOPIJCMJ_00435 1236902.ANAS01000037_gene5376 5.2e-59 234.6 Streptosporangiales glpQ2 3.1.4.46 ko:K01126 ko00564,map00564 R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 Bacteria 2GJ5W@201174,4EIE7@85012,COG0584@1,COG0584@2 NA|NA|NA C Glycerophosphoryl diester phosphodiesterase family KOPIJCMJ_00436 543632.JOJL01000020_gene553 2.5e-55 223.4 Micromonosporales ko:K14645 ko02024,map02024 ko00000,ko00001,ko01000,ko01002,ko03110 Bacteria 2GIRE@201174,4DAEM@85008,COG1404@1,COG1404@2 NA|NA|NA O Belongs to the peptidase S8 family KOPIJCMJ_00437 1193181.BN10_560016 2.1e-184 652.1 Intrasporangiaceae Bacteria 2HZZ8@201174,4FHJM@85021,COG4974@1,COG4974@2 NA|NA|NA L Belongs to the 'phage' integrase family KOPIJCMJ_00438 1137268.AZXF01000006_gene2058 4.9e-19 100.1 Streptosporangiales cah 4.2.1.1 ko:K01673 ko00910,map00910 R00132,R10092 RC02807 ko00000,ko00001,ko01000 Bacteria 2GM1M@201174,4EIY6@85012,COG0288@1,COG0288@2 NA|NA|NA P Reversible hydration of carbon dioxide KOPIJCMJ_00439 469371.Tbis_2394 2e-273 948.3 Pseudonocardiales gyrB2 5.99.1.3 ko:K02470 ko00000,ko01000,ko03032,ko03400 Bacteria 2GM1E@201174,4DZQK@85010,COG0187@1,COG0187@2 NA|NA|NA L PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase KOPIJCMJ_00440 446468.Ndas_3308 6.3e-10 69.7 Streptosporangiales Bacteria 2E39Y@1,2GQJA@201174,32Y9G@2,4EKEQ@85012 NA|NA|NA KOPIJCMJ_00441 37919.EP51_31660 4.2e-30 137.9 Nocardiaceae yqgC ko:K09793 ko00000 Bacteria 2IQDE@201174,4G1BR@85025,COG2839@1,COG2839@2 NA|NA|NA S Protein of unknown function (DUF456) KOPIJCMJ_00443 882086.SacxiDRAFT_0618 0.0 1187.9 Pseudonocardiales hrpA GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 ko:K03578 ko00000,ko01000 Bacteria 2GIWX@201174,4E02F@85010,COG1643@1,COG1643@2 NA|NA|NA L TIGRFAM ATP-dependent helicase HrpA KOPIJCMJ_00444 1348663.KCH_12620 4.5e-189 667.5 Kitasatospora guaC GO:0003674,GO:0003824,GO:0003920,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0015949,GO:0015950,GO:0015951,GO:0016020,GO:0016491,GO:0016651,GO:0016657,GO:0019637,GO:0019693,GO:0034641,GO:0042802,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.1.1.205,1.7.1.7 ko:K00088,ko:K00364 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R01134,R08240 RC00143,RC00457,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 iEC042_1314.EC042_0103,iECIAI39_1322.ECIAI39_0105,iECUMN_1333.ECUMN_0102 Bacteria 2GNDC@201174,2M0KH@2063,COG0516@1,COG0516@2,COG0517@1,COG0517@2 NA|NA|NA F IMP dehydrogenase / GMP reductase domain KOPIJCMJ_00445 446471.Xcel_0116 4.8e-31 141.4 Promicromonosporaceae 5.4.2.12 ko:K15634,ko:K15640 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 Bacteria 2GK2I@201174,4F5AK@85017,COG0406@1,COG0406@2 NA|NA|NA G Phosphoglycerate mutase family KOPIJCMJ_00446 1304865.JAGF01000001_gene2260 9.1e-230 803.1 Actinobacteria bglF ko:K02755,ko:K02756,ko:K02757 ko02060,map02060 M00271 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.2.11,4.A.1.2.2,4.A.1.2.5,4.A.1.2.6 Bacteria 2GK6B@201174,COG1263@1,COG1263@2,COG1264@1,COG1264@2,COG2190@1,COG2190@2 NA|NA|NA G Pts system KOPIJCMJ_00447 1211815.CBYP010000036_gene2210 4e-62 245.7 Frankiales Bacteria 2GK1J@201174,4ERY7@85013,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor KOPIJCMJ_00448 1313172.YM304_19260 3.4e-54 218.4 Acidimicrobiia Bacteria 2GKFS@201174,4CMYH@84992,COG0745@1,COG0745@2 NA|NA|NA K Transcriptional regulatory protein, C terminal KOPIJCMJ_00449 1380370.JIBA01000005_gene614 2.9e-63 248.8 Intrasporangiaceae Bacteria 2IMQQ@201174,4FFD0@85021,COG2267@1,COG2267@2 NA|NA|NA I Serine aminopeptidase, S33 KOPIJCMJ_00450 188626.HMPREF0321_0345 2.4e-117 429.5 Dermacoccaceae deaD 3.6.4.13 ko:K05592,ko:K11927 ko03018,map03018 ko00000,ko00001,ko01000,ko03009,ko03019 Bacteria 1ZVH9@145357,2GIUR@201174,COG0513@1,COG0513@2 NA|NA|NA L helicase superfamily c-terminal domain KOPIJCMJ_00451 494419.ALPM01000021_gene79 1.5e-113 417.2 Micrococcaceae Bacteria 1WB1I@1268,2GIZF@201174,COG5001@1,COG5001@2 NA|NA|NA T diguanylate cyclase KOPIJCMJ_00452 1236902.ANAS01000023_gene3362 2.1e-14 85.5 Actinobacteria Bacteria 2GVSD@201174,COG1714@1,COG1714@2 NA|NA|NA S RDD family KOPIJCMJ_00453 471853.Bcav_1837 5.4e-180 637.5 Actinobacteria hutH 4.3.1.3 ko:K01745 ko00340,ko01100,map00340,map01100 M00045 R01168 RC00361 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJZW@201174,COG2986@1,COG2986@2 NA|NA|NA E Histidine ammonia-lyase KOPIJCMJ_00454 1192034.CAP_2819 1.2e-24 120.6 Myxococcales Bacteria 1NAQM@1224,2WNXU@28221,2YVQF@29,42RR6@68525,COG1946@1,COG1946@2 NA|NA|NA I Thioesterase-like superfamily KOPIJCMJ_00455 644283.Micau_1166 2e-260 904.8 Micromonosporales hutU 4.2.1.49 ko:K01712 ko00340,ko01100,map00340,map01100 M00045 R02914 RC00804 ko00000,ko00001,ko00002,ko01000 Bacteria 2GP10@201174,4D9Y2@85008,COG2987@1,COG2987@2 NA|NA|NA E Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate KOPIJCMJ_00456 644283.Micau_1163 1.9e-143 515.8 Micromonosporales hutI GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006547,GO:0006548,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046395,GO:0046483,GO:0046700,GO:0052803,GO:0052805,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 3.5.2.7 ko:K01468 ko00340,ko01100,map00340,map01100 M00045 R02288 RC00683 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJH4@201174,4DBJ2@85008,COG1228@1,COG1228@2 NA|NA|NA Q hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides KOPIJCMJ_00457 1120960.ATXG01000004_gene1805 3.2e-87 328.6 Microbacteriaceae hutG 3.5.3.11,3.5.3.8 ko:K01479,ko:K01480 ko00330,ko00340,ko01100,map00330,map00340,map01100 M00045,M00133 R01157,R02285 RC00024,RC00221,RC00329,RC00681 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJA6@201174,4FKS9@85023,COG0010@1,COG0010@2 NA|NA|NA E Arginase family KOPIJCMJ_00458 1304865.JAGF01000001_gene497 1e-71 276.9 Actinobacteria Bacteria 2GQC1@201174,COG2267@1,COG2267@2 NA|NA|NA I Alpha beta hydrolase KOPIJCMJ_00459 312284.A20C1_11546 1.4e-45 189.5 unclassified Actinobacteria (class) Bacteria 2HP5X@201174,3UXNT@52018,COG1309@1,COG1309@2 NA|NA|NA K WHG domain KOPIJCMJ_00460 796942.HMPREF9623_01830 2.7e-70 272.3 Clostridia Bacteria 1TSAT@1239,24A6W@186801,COG0535@1,COG0535@2 NA|NA|NA S radical SAM domain protein KOPIJCMJ_00462 1211815.CBYP010000051_gene683 5.2e-21 108.2 Frankiales ko:K03265 ko03015,map03015 ko00000,ko00001,ko03012,ko03019 Bacteria 2IFQH@201174,4ET50@85013,COG1503@1,COG1503@2 NA|NA|NA J translation release factor activity KOPIJCMJ_00463 44060.JODL01000025_gene142 3.7e-39 168.3 Actinobacteria Bacteria 2GNIP@201174,COG1309@1,COG1309@2 NA|NA|NA K transcriptional regulator KOPIJCMJ_00464 909613.UO65_3763 3.4e-265 921.0 Pseudonocardiales fadB 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ50@201174,4E0TU@85010,COG1024@1,COG1024@2,COG1250@1,COG1250@2 NA|NA|NA I 3-hydroxyacyl-CoA dehydrogenase KOPIJCMJ_00465 909613.UO65_3764 3.1e-175 621.3 Pseudonocardiales 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GJAC@201174,4DXDP@85010,COG0183@1,COG0183@2 NA|NA|NA I Belongs to the thiolase family KOPIJCMJ_00466 1278078.G419_22134 0.0 1184.1 Nocardiaceae 3.6.3.8 ko:K01537 ko00000,ko01000 3.A.3.2 Bacteria 2GJJC@201174,4FU7Y@85025,COG0474@1,COG0474@2 NA|NA|NA P PFAM E1-E2 ATPase-associated domain protein, Haloacid dehalogenase domain protein hydrolase, cation transporting ATPase domain protein KOPIJCMJ_00467 479431.Namu_1914 9.4e-104 383.3 Frankiales nagD ko:K02566 ko00000 Bacteria 2GJG6@201174,4EU6R@85013,COG0647@1,COG0647@2 NA|NA|NA G Belongs to the HAD-like hydrolase superfamily KOPIJCMJ_00468 479431.Namu_1913 1.2e-114 419.9 Actinobacteria egsA 1.1.1.261 ko:K00096 ko00564,map00564 R05679,R05680 RC00029 ko00000,ko00001,ko01000 Bacteria 2GKWA@201174,COG0371@1,COG0371@2 NA|NA|NA C Dehydrogenase KOPIJCMJ_00469 479431.Namu_4836 1.7e-108 399.4 Frankiales alx ko:K05794 ko00000 Bacteria 2GIWU@201174,4ERNE@85013,COG0861@1,COG0861@2 NA|NA|NA P membrane protein, TerC KOPIJCMJ_00470 1283283.ATXA01000007_gene3910 1.7e-120 440.3 Frankiales Bacteria 2GIZF@201174,4ERVM@85013,COG5001@1,COG5001@2 NA|NA|NA T Diguanylate cyclase KOPIJCMJ_00471 590998.Celf_3653 8.9e-51 208.4 Actinobacteria Bacteria 2GIZF@201174,COG2202@1,COG2202@2,COG5001@1,COG5001@2,COG5002@1,COG5002@2 NA|NA|NA T signal transduction protein containing a membrane domain an EAL and a GGDEF domain KOPIJCMJ_00472 1445613.JALM01000036_gene2693 1.6e-11 75.5 Pseudonocardiales Bacteria 2DGB7@1,2GV3X@201174,2ZV98@2,4E6RY@85010 NA|NA|NA KOPIJCMJ_00473 1713.JOFV01000013_gene966 3.2e-225 788.1 Cellulomonadaceae ko:K06147 ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 2GITR@201174,4F0WR@85016,COG1132@1,COG1132@2 NA|NA|NA V ABC transporter transmembrane region KOPIJCMJ_00474 235985.BBPN01000007_gene3291 6.7e-187 660.6 Streptacidiphilus ycfI ko:K06147 ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 2GITR@201174,2NEN1@228398,COG1132@1,COG1132@2 NA|NA|NA V ABC transporter transmembrane region KOPIJCMJ_00475 2045.KR76_02335 1.5e-18 101.7 Propionibacteriales Bacteria 2HQ5S@201174,4DS25@85009,COG4585@1,COG4585@2 NA|NA|NA T Histidine kinase-like ATPases KOPIJCMJ_00476 222534.KB893694_gene64 1.2e-30 140.2 Frankiales Bacteria 2I8Y7@201174,4EWZT@85013,COG2197@1,COG2197@2 NA|NA|NA T Response regulator receiver KOPIJCMJ_00477 66897.DJ64_20775 3.5e-116 424.9 Actinobacteria 3.2.1.23,3.2.1.97 ko:K01190,ko:K17624 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 GH101 Bacteria 2I952@201174,COG3250@1,COG3250@2 NA|NA|NA G Protein of unknown function (DUF2804) KOPIJCMJ_00478 1348338.ADILRU_1018 4e-31 140.6 Microbacteriaceae ko:K21600 ko00000,ko03000 Bacteria 2IQAC@201174,4FPHS@85023,COG1937@1,COG1937@2 NA|NA|NA S Metal-sensitive transcriptional repressor KOPIJCMJ_00481 1116232.AHBF01000163_gene5903 2.9e-19 101.7 Actinobacteria Bacteria 28N6D@1,2HMGF@201174,2ZBB9@2 NA|NA|NA KOPIJCMJ_00482 1449347.JQLN01000007_gene980 1.1e-49 203.8 Bacteria Bacteria COG4249@1,COG4249@2 NA|NA|NA S B-1 B cell differentiation KOPIJCMJ_00484 369723.Strop_4549 6.3e-26 125.6 Micromonosporales Bacteria 2ATXZ@1,2GN21@201174,31JHI@2,4D910@85008 NA|NA|NA S Glycosyltransferase family 87 KOPIJCMJ_00485 1298863.AUEP01000004_gene1929 3.6e-59 234.6 Propionibacteriales Bacteria 2GMV1@201174,4DQXT@85009,COG1846@1,COG1846@2 NA|NA|NA K Transcriptional regulator, MarR family KOPIJCMJ_00486 196162.Noca_2052 3e-59 235.0 Propionibacteriales 1.5.1.40 ko:K06988 ko00000,ko01000 Bacteria 2GMZ5@201174,4DQQN@85009,COG2085@1,COG2085@2 NA|NA|NA S NADP oxidoreductase coenzyme F420-dependent KOPIJCMJ_00487 1454010.JEOE01000004_gene180 4.7e-52 211.8 Actinobacteria ko:K02529 ko00000,ko03000 Bacteria 2GQER@201174,COG1609@1,COG1609@2 NA|NA|NA K PFAM regulatory protein LacI KOPIJCMJ_00488 512565.AMIS_17490 2.1e-07 63.2 Micromonosporales Bacteria 2GJKC@201174,4DBA8@85008,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor KOPIJCMJ_00489 67373.JOBF01000006_gene2672 3.2e-27 128.6 Actinobacteria Bacteria 2GN1H@201174,COG1680@1,COG1680@2 NA|NA|NA V Beta-lactamase KOPIJCMJ_00491 1223523.H340_08198 2.6e-40 171.0 Actinobacteria nuoD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2GKEZ@201174,COG0649@1,COG0649@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient KOPIJCMJ_00492 1504319.GM45_4140 1.6e-64 252.7 unclassified Actinobacteria (class) nuoE GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3,1.6.99.3 ko:K00334,ko:K00335,ko:K03943 ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016 M00143,M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1,3.D.1.6 Bacteria 2GKG0@201174,3UWSV@52018,COG1905@1,COG1905@2 NA|NA|NA C Thioredoxin-like [2Fe-2S] ferredoxin KOPIJCMJ_00493 1504319.GM45_4145 1.4e-184 652.5 unclassified Actinobacteria (class) nuoF 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2GMMC@201174,3UWD5@52018,COG1894@1,COG1894@2 NA|NA|NA C NADH-ubiquinone oxidoreductase-F iron-sulfur binding region KOPIJCMJ_00494 1429046.RR21198_5847 5.6e-256 890.6 Nocardiaceae nuoG GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009405,GO:0010941,GO:0016020,GO:0016491,GO:0016651,GO:0030312,GO:0033668,GO:0035821,GO:0042981,GO:0043067,GO:0043069,GO:0044003,GO:0044068,GO:0044403,GO:0044419,GO:0044464,GO:0044531,GO:0044532,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051536,GO:0051540,GO:0051701,GO:0051704,GO:0051817,GO:0052040,GO:0052041,GO:0052150,GO:0052248,GO:0052433,GO:0052490,GO:0055114,GO:0060548,GO:0065007,GO:0071944 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2GJGX@201174,4FXK7@85025,COG1034@1,COG1034@2 NA|NA|NA C NADH-ubiquinone oxidoreductase-G iron-sulfur binding region KOPIJCMJ_00496 1137271.AZUM01000001_gene905 1.6e-07 61.6 Pseudonocardiales Bacteria 2GJBJ@201174,4E2I8@85010,COG1609@1,COG1609@2 NA|NA|NA K Bacterial regulatory proteins, lacI family KOPIJCMJ_00497 1032480.MLP_11610 5.3e-46 191.4 Actinobacteria Bacteria 2IFGR@201174,COG2865@1,COG2865@2 NA|NA|NA K Putative DNA-binding domain KOPIJCMJ_00498 1219065.VPR01S_05_01810 1.1e-47 196.4 Vibrionales lacA 2.3.1.79 ko:K00661 ko00000,ko01000 Bacteria 1RF1T@1224,1S4DA@1236,1XTJQ@135623,COG0110@1,COG0110@2 NA|NA|NA S COG0110 Acetyltransferase (isoleucine patch superfamily) KOPIJCMJ_00499 521674.Plim_2873 6.8e-71 275.0 Planctomycetes mmoQ Bacteria 2IZRQ@203682,COG1639@1,COG1639@2,COG2199@1,COG3706@2 NA|NA|NA T signal transduction protein KOPIJCMJ_00500 1136417.AZWE01000016_gene64 7.8e-73 281.2 Micromonosporales yibF Bacteria 2GKJ4@201174,4D8GP@85008,COG5438@1,COG5438@2 NA|NA|NA S YibE F family protein KOPIJCMJ_00501 446466.Cfla_1918 1e-59 236.9 Actinobacteria ko:K00241 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 Bacteria 28HIR@1,2I860@201174,30UAY@2 NA|NA|NA S succinate dehydrogenase KOPIJCMJ_00503 1449355.JQNR01000003_gene273 2.7e-55 222.2 Actinobacteria yvaK 3.1.1.1 ko:K03928 ko00000,ko01000 Bacteria 2GM1Y@201174,COG1647@1,COG1647@2 NA|NA|NA S Esterase KOPIJCMJ_00504 55952.BU52_09430 6.2e-22 110.5 Actinobacteria Bacteria 2E49S@1,2I83P@201174,32RRE@2 NA|NA|NA S Protein of unknown function (DUF3040) KOPIJCMJ_00505 1172188.KB911827_gene4382 3e-136 491.9 Intrasporangiaceae dinB 2.7.7.7 ko:K02346 ko00000,ko01000,ko03400 Bacteria 2GKBI@201174,4FE61@85021,COG0389@1,COG0389@2 NA|NA|NA L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII KOPIJCMJ_00506 1121017.AUFG01000001_gene3000 0.0 1368.2 Intrasporangiaceae dnaE2 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 2GJ1P@201174,4FEK0@85021,COG0587@1,COG0587@2 NA|NA|NA L Belongs to the DNA polymerase type-C family. DnaE2 subfamily KOPIJCMJ_00507 1380356.JNIK01000021_gene4429 6.4e-27 127.1 Frankiales Bacteria 2CGM3@1,2GP7H@201174,32S47@2,4ET5Q@85013 NA|NA|NA KOPIJCMJ_00508 1123320.KB889675_gene3873 1.9e-20 105.1 Actinobacteria Bacteria 2ERD0@1,2GVR1@201174,33IYN@2 NA|NA|NA KOPIJCMJ_00509 1146883.BLASA_0920 3e-69 268.5 Frankiales crtA 1.14.15.9 ko:K09847 ko00906,ko01100,map00906,map01100 R07525,R07526,R07537,R07538 RC02084 ko00000,ko00001,ko01000 Bacteria 29UQ5@1,2II02@201174,30G1W@2,4EV3Q@85013 NA|NA|NA C spheroidene monooxygenase KOPIJCMJ_00511 1048339.KB913029_gene4359 1.3e-49 203.4 Frankiales 5.5.1.19 ko:K22502 ko00906,map00906 R03824,R05341 RC01004 ko00000,ko00001,ko01000 Bacteria 2IIUJ@201174,4EVC1@85013,COG2324@1,COG2324@2 NA|NA|NA S Carotenoid biosynthesis protein KOPIJCMJ_00512 266940.Krad_3224 2.5e-92 345.9 Actinobacteria ko:K14597 ko00906,map00906 R07544,R07546 RC00262 ko00000,ko00001 Bacteria 2GJZI@201174,COG1215@1,COG1215@2 NA|NA|NA M Glycosyl transferase, family 2 KOPIJCMJ_00513 1380356.JNIK01000013_gene4257 8.4e-170 603.6 Frankiales crtD 1.3.99.26,1.3.99.27,1.3.99.28,1.3.99.29,1.3.99.31,5.4.99.9 ko:K01854,ko:K09845,ko:K10027 ko00052,ko00520,ko00906,ko01100,ko01110,map00052,map00520,map00906,map01100,map01110 R00505,R04787,R04798,R04800,R07517,R07520,R07523,R07534,R09009,R09691,R09692 RC00317,RC01214,RC02080,RC02088,RC02396,RC02605 ko00000,ko00001,ko01000 Bacteria 2GJAV@201174,4ETTQ@85013,COG1233@1,COG1233@2 NA|NA|NA Q Flavin containing amine oxidoreductase KOPIJCMJ_00514 1246995.AFR_10060 2.6e-77 295.8 Micromonosporales cvrA ko:K11105 ko00000,ko02000 2.A.36.6 Bacteria 2GJ9B@201174,4D9E3@85008,COG3263@1,COG3263@2 NA|NA|NA P Sodium/hydrogen exchanger family KOPIJCMJ_00515 266940.Krad_4429 3.1e-191 674.9 Actinobacteria pepO 3.4.24.11,3.4.24.71 ko:K01389,ko:K01415,ko:K07386 ko04614,ko04640,ko04974,ko05010,map04614,map04640,map04974,map05010 ko00000,ko00001,ko01000,ko01002,ko04090,ko04147 Bacteria 2GNJY@201174,COG3590@1,COG3590@2 NA|NA|NA O peptidase KOPIJCMJ_00516 65393.PCC7424_3789 1.4e-07 63.9 Bacteria Bacteria COG2120@1,COG2120@2 NA|NA|NA S N-acetylglucosaminylinositol deacetylase activity KOPIJCMJ_00518 862751.SACTE_4123 1.6e-97 362.5 Actinobacteria bhbA 5.4.99.2 ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 Bacteria 2GM65@201174,COG1884@1,COG1884@2 NA|NA|NA I Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly KOPIJCMJ_00519 1157638.KB892158_gene5453 1.8e-123 449.1 Actinobacteria add GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659 3.5.4.4 ko:K01488 ko00230,ko01100,ko05340,map00230,map01100,map05340 R01560,R02556 RC00477 ko00000,ko00001,ko01000 iNJ661.Rv3313c Bacteria 2GJ6I@201174,COG1816@1,COG1816@2 NA|NA|NA F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism KOPIJCMJ_00520 1278078.G419_15843 1.3e-43 183.3 Nocardiaceae deoC GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 4.1.2.4 ko:K01619 ko00030,map00030 R01066 RC00436,RC00437 ko00000,ko00001,ko01000 iSB619.SA_RS00835 Bacteria 2GJIR@201174,4FX02@85025,COG0274@1,COG0274@2 NA|NA|NA F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate KOPIJCMJ_00521 585531.HMPREF0063_11453 1e-89 336.7 Propionibacteriales punA GO:0003674,GO:0003824,GO:0004731,GO:0006139,GO:0006152,GO:0006161,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009116,GO:0009120,GO:0009164,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0019439,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042453,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046121,GO:0046122,GO:0046124,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658 2.4.2.1 ko:K03783 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244 RC00033,RC00063,RC00122 ko00000,ko00001,ko01000 Bacteria 2GKEI@201174,4DMXP@85009,COG0005@1,COG0005@2 NA|NA|NA F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate KOPIJCMJ_00522 471852.Tcur_4181 2.4e-47 194.9 Streptosporangiales ykqA Bacteria 2GJM9@201174,4EIZE@85012,COG3703@1,COG3703@2 NA|NA|NA P AIG2-like family KOPIJCMJ_00523 397278.JOJN01000001_gene2858 4.7e-159 567.8 Propionibacteriales lpdA GO:0000166,GO:0003674,GO:0003824,GO:0003955,GO:0005488,GO:0008150,GO:0008152,GO:0009405,GO:0016491,GO:0016651,GO:0016655,GO:0036094,GO:0043167,GO:0043168,GO:0044419,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0051704,GO:0055114,GO:0070401,GO:0097159,GO:1901265,GO:1901363 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GMP7@201174,4DNPF@85009,COG1249@1,COG1249@2 NA|NA|NA C Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain KOPIJCMJ_00524 479433.Caci_0809 2.2e-249 868.2 Actinobacteria bccA 6.3.4.14,6.4.1.2,6.4.1.3 ko:K11263 ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00741 R00742,R01859,R04385 RC00040,RC00097,RC00253,RC00367,RC00609 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIZP@201174,COG4770@1,COG4770@2 NA|NA|NA I carboxylase KOPIJCMJ_00525 2074.JNYD01000012_gene432 3.6e-48 198.4 Pseudonocardiales maf GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0030312,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0047429,GO:0071944 1.1.1.25,2.1.1.190 ko:K00014,ko:K03215,ko:K06287 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000,ko03009 Bacteria 2GNI0@201174,4E2ME@85010,COG0424@1,COG0424@2 NA|NA|NA D Maf-like protein KOPIJCMJ_00527 1385520.N802_11095 1.8e-92 345.5 Actinobacteria Bacteria 2AAWD@1,2IG0D@201174,3109H@2 NA|NA|NA S Alkylmercury lyase KOPIJCMJ_00528 882083.SacmaDRAFT_4675 1.2e-42 180.3 Actinobacteria Bacteria 2IAWJ@201174,COG2345@1,COG2345@2 NA|NA|NA K Transcriptional regulator KOPIJCMJ_00529 754252.PFREUD_23710 3.5e-94 352.1 Actinobacteria eryK Bacteria 2IJFZ@201174,COG2124@1,COG2124@2 NA|NA|NA C Cytochrome P450 KOPIJCMJ_00530 1276920.ADIAG_02147 1.7e-26 125.2 Actinobacteria Bacteria 2GS7C@201174,COG4309@1,COG4309@2 NA|NA|NA S Uncharacterized conserved protein (DUF2249) KOPIJCMJ_00531 1211815.CBYP010000005_gene232 6.5e-20 105.1 Actinobacteria Bacteria 2GVAC@201174,COG1277@1,COG1277@2 NA|NA|NA S ABC-type transport system involved in multi-copper enzyme maturation permease component KOPIJCMJ_00532 2045.KR76_15710 5.9e-07 60.1 Propionibacteriales ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GN8P@201174,4DP9K@85009,COG1131@1,COG1131@2 NA|NA|NA V AAA domain, putative AbiEii toxin, Type IV TA system KOPIJCMJ_00533 1122138.AQUZ01000069_gene2244 2e-19 100.9 Propionibacteriales sdhB GO:0000104,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0022904,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0048037,GO:0051536,GO:0051537,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072350,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.3.5.1,1.3.5.4 ko:K00240 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 e_coli_core.b0724,iAF1260.b0724,iBWG_1329.BWG_0583,iEC042_1314.EC042_0742,iECDH10B_1368.ECDH10B_0791,iECDH1ME8569_1439.ECDH1ME8569_0683,iECUMN_1333.ECUMN_0802,iEcDH1_1363.EcDH1_2911,iJO1366.b0724,iJR904.b0724,iY75_1357.Y75_RS03765 Bacteria 2GJPS@201174,4DPU6@85009,COG0479@1,COG0479@2 NA|NA|NA C Succinate dehydrogenase fumarate reductase KOPIJCMJ_00534 1385518.N798_04965 9.7e-57 228.0 Intrasporangiaceae dac 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 ko00000,ko00001,ko01000,ko01002,ko01011 Bacteria 2GK3M@201174,4FFP2@85021,COG1686@1,COG1686@2 NA|NA|NA M Belongs to the peptidase S11 family KOPIJCMJ_00535 1440053.JOEI01000007_gene2497 5.9e-41 173.7 Actinobacteria fruA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090582 2.7.1.202,2.7.1.56 ko:K00882,ko:K02768,ko:K02769,ko:K02770,ko:K02806,ko:K11202 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273,M00306 R02071,R03232 RC00002,RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1 iEcSMS35_1347.EcSMS35_2314,iJN746.PP_0795,iSbBS512_1146.SbBS512_E0796 Bacteria 2GJU4@201174,COG1299@1,COG1299@2,COG1445@1,COG1445@2,COG1762@1,COG1762@2 NA|NA|NA GT Phosphotransferase System KOPIJCMJ_00536 465541.ATCJ01000005_gene768 2.3e-19 102.1 Actinobacteria Bacteria 2E4ST@1,2GSCH@201174,32ZM5@2 NA|NA|NA KOPIJCMJ_00537 446471.Xcel_3424 2.7e-17 95.1 Promicromonosporaceae Bacteria 2GRCJ@201174,4F5S5@85017,COG4961@1,COG4961@2 NA|NA|NA U TadE-like protein KOPIJCMJ_00538 408672.NBCG_01573 4.7e-49 201.4 Propionibacteriales Bacteria 2DVVA@1,2IHH0@201174,32V07@2,4DRC3@85009 NA|NA|NA KOPIJCMJ_00540 1380354.JIAN01000009_gene3757 2.9e-11 75.1 Bacteria Bacteria COG4961@1,COG4961@2 NA|NA|NA U PFAM TadE family protein KOPIJCMJ_00543 1306174.JODP01000002_gene5587 1.1e-174 619.8 Actinobacteria glgP GO:0000272,GO:0003674,GO:0003824,GO:0004645,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0005977,GO:0005980,GO:0006073,GO:0006091,GO:0006112,GO:0008144,GO:0008150,GO:0008152,GO:0008184,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0015980,GO:0016052,GO:0016740,GO:0016757,GO:0016758,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901575 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 R02111 ko00000,ko00001,ko01000 GT35 Bacteria 2GIVZ@201174,COG0058@1,COG0058@2 NA|NA|NA G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties KOPIJCMJ_00544 1463856.JOHY01000039_gene1645 1.7e-138 499.2 Actinobacteria mrp GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 ko:K03593 ko00000,ko03029,ko03036 Bacteria 2GJUZ@201174,COG0489@1,COG0489@2 NA|NA|NA D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP KOPIJCMJ_00545 471852.Tcur_1187 6.5e-08 64.3 Streptosporangiales tatB GO:0008150,GO:0040007 ko:K03116,ko:K03117 ko03060,ko03070,map03060,map03070 M00336 ko00000,ko00001,ko00002,ko02044 2.A.64 Bacteria 2IR0U@201174,4EKBD@85012,COG1826@1,COG1826@2 NA|NA|NA U mttA/Hcf106 family KOPIJCMJ_00546 1223523.H340_31413 1e-87 330.9 Actinobacteria 3.4.21.107 ko:K04771,ko:K08372 ko01503,ko02020,map01503,map02020 M00728 ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 Bacteria 2GJ96@201174,COG0265@1,COG0265@2 NA|NA|NA O Peptidase s1 and s6 chymotrypsin hap KOPIJCMJ_00547 1283287.KB822583_gene2793 1.3e-66 259.6 Propionibacteriales safC GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 Bacteria 2GPEV@201174,4DNEI@85009,COG4122@1,COG4122@2 NA|NA|NA S O-methyltransferase KOPIJCMJ_00548 1394178.AWOO02000057_gene737 2e-99 369.8 Streptosporangiales 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 Bacteria 2GJRB@201174,4EFVT@85012,COG0260@1,COG0260@2 NA|NA|NA E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides KOPIJCMJ_00549 561175.KB894095_gene2192 4.3e-19 99.8 Streptosporangiales Bacteria 2E39N@1,2GQFF@201174,32Y97@2,4EKN2@85012 NA|NA|NA S Protein of unknown function (DUF3117) KOPIJCMJ_00550 1380393.JHVP01000007_gene4322 4.3e-24 117.9 Frankiales Bacteria 2II8Y@201174,4ETJ6@85013,COG3427@1,COG3427@2 NA|NA|NA S Polyketide cyclase / dehydrase and lipid transport KOPIJCMJ_00551 479433.Caci_7945 1.3e-07 62.4 Bacteria Bacteria COG3599@1,COG3599@2 NA|NA|NA D regulation of cell shape KOPIJCMJ_00552 1343740.M271_18215 1.9e-105 389.0 Actinobacteria folP2 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJNI@201174,COG0294@1,COG0294@2 NA|NA|NA H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives KOPIJCMJ_00553 1229203.KI301992_gene1914 9.4e-96 356.7 unclassified Actinobacteria (class) fmt2 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 Bacteria 2GKJH@201174,3UXFN@52018,COG1611@1,COG1611@2 NA|NA|NA S Possible lysine decarboxylase KOPIJCMJ_00554 298654.FraEuI1c_2189 2.5e-55 221.9 Frankiales yceI Bacteria 2GJUB@201174,4ESN7@85013,COG2353@1,COG2353@2 NA|NA|NA S Belongs to the UPF0312 family KOPIJCMJ_00555 1048339.KB913029_gene25 3.2e-123 448.4 Frankiales dapE GO:0008150,GO:0040007 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 Bacteria 2GK09@201174,4ES00@85013,COG0624@1,COG0624@2 NA|NA|NA E Succinyl-diaminopimelate desuccinylase KOPIJCMJ_00556 1210045.ALNP01000010_gene1189 2.5e-103 382.1 Actinobacteria dapD GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008666,GO:0016020,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016749,GO:0030312,GO:0031402,GO:0031420,GO:0040007,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0048037,GO:0050662,GO:0071944 2.3.1.117 ko:K00674 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04365 RC00004,RC01136 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1201c Bacteria 2GIZ9@201174,COG2171@1,COG2171@2 NA|NA|NA E Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA KOPIJCMJ_00558 1122611.KB903974_gene2937 6.8e-36 157.1 Streptosporangiales Bacteria 2GMPH@201174,4EJKB@85012,COG1853@1,COG1853@2 NA|NA|NA S Flavin reductase like domain KOPIJCMJ_00559 1120950.KB892823_gene520 1.3e-94 354.0 Propionibacteriales vanW Bacteria 2GISH@201174,4DN8K@85009,COG2720@1,COG2720@2 NA|NA|NA V Putative peptidoglycan binding domain KOPIJCMJ_00560 1184609.KILIM_030_00650 7.1e-50 203.0 Dermatophilaceae fdxA ko:K05524 ko00000 Bacteria 2IKVN@201174,4F715@85018,COG1146@1,COG1146@2 NA|NA|NA C 4Fe-4S binding domain KOPIJCMJ_00561 1246995.AFR_38740 3.3e-133 481.5 Micromonosporales dapC Bacteria 2GJMI@201174,4DB04@85008,COG0436@1,COG0436@2 NA|NA|NA E Aminotransferase KOPIJCMJ_00562 981369.JQMJ01000004_gene3995 1.6e-69 269.2 Streptacidiphilus Bacteria 2DKWQ@1,2I3CS@201174,2NF74@228398,30MQE@2 NA|NA|NA S Glyoxalase-like domain KOPIJCMJ_00566 1380354.JIAN01000005_gene2339 1.1e-23 116.7 Actinobacteria ko:K02529 ko00000,ko03000 Bacteria 2GQER@201174,COG1609@1,COG1609@2 NA|NA|NA K PFAM regulatory protein LacI KOPIJCMJ_00567 710696.Intca_0789 5.4e-21 106.7 Intrasporangiaceae Bacteria 2GS79@201174,4FFP0@85021,COG3547@1,COG3547@2 NA|NA|NA L Transposase KOPIJCMJ_00568 1193181.BN10_160001 1.7e-195 688.7 Intrasporangiaceae ko:K07493 ko00000 Bacteria 2GM8F@201174,4FJAV@85021,COG3328@1,COG3328@2 NA|NA|NA L Transposase, Mutator family KOPIJCMJ_00569 33876.JNXY01000001_gene6365 5.5e-117 427.6 Micromonosporales ko:K07497 ko00000 Bacteria 2GNRT@201174,4DHN8@85008,COG2801@1,COG2801@2 NA|NA|NA L Integrase core domain KOPIJCMJ_00570 1121927.GOHSU_24_00140 2.1e-39 168.7 Actinobacteria ko:K07483,ko:K07497 ko00000 Bacteria 2IP84@201174,COG2963@1,COG2963@2 NA|NA|NA L 4.5 Transposon and IS KOPIJCMJ_00573 1304865.JAGF01000001_gene2477 0.0 1954.1 Actinobacteria nifJ 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2I995@201174,COG0674@1,COG0674@2,COG1013@1,COG1013@2,COG1014@1,COG1014@2,COG1144@1,COG1144@2,COG1145@1,COG1145@2 NA|NA|NA C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin KOPIJCMJ_00574 1304865.JAGF01000001_gene2476 5.6e-227 793.5 Cellulomonadaceae gltA 1.18.1.2,1.19.1.1,1.4.1.13,1.4.1.14 ko:K00266,ko:K00528,ko:K02823 ko00240,ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00240,map00250,map00910,map01100,map01110,map01120,map01130,map01230 R00093,R00114,R00248,R10159 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 Bacteria 2GJ0A@201174,4F0FS@85016,COG0493@1,COG0493@2,COG0543@1,COG0543@2 NA|NA|NA E TIGRFAM glutamate synthase, NADH NADPH, small subunit KOPIJCMJ_00575 367299.JOEE01000004_gene1013 3.1e-88 332.4 Bacteria ko:K08642 ko02024,map02024 ko00000,ko00001,ko01000,ko01002 Bacteria COG0739@1,COG0739@2 NA|NA|NA M heme binding KOPIJCMJ_00576 1306174.JODP01000013_gene7557 1.5e-51 209.1 Actinobacteria hit GO:0003674,GO:0003824,GO:0003877,GO:0004551,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008796,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009987,GO:0015959,GO:0015961,GO:0015965,GO:0015967,GO:0016020,GO:0016462,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0070566,GO:0071704,GO:0071944,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 2.7.7.53 ko:K19710 ko00230,map00230 R00126,R01618 RC00002,RC02753,RC02795 ko00000,ko00001,ko01000 Bacteria 2GJT5@201174,COG0537@1,COG0537@2 NA|NA|NA FG Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases KOPIJCMJ_00577 1077972.ARGLB_080_00570 2.1e-07 63.9 Micrococcaceae Bacteria 1W96H@1268,2GXWA@201174,COG4932@1,COG4932@2 NA|NA|NA M Belongs to the peptidase S8 family KOPIJCMJ_00578 1120949.KB903314_gene339 1.1e-150 539.7 Actinobacteria ybdK GO:0003674,GO:0003824,GO:0016874,GO:0016879 ko:K06048 ko00000,ko01000 Bacteria 2GKAA@201174,COG2170@1,COG2170@2 NA|NA|NA S ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity KOPIJCMJ_00579 68260.JOAY01000008_gene658 3.3e-67 261.2 Actinobacteria thrS GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 2GKTC@201174,COG0441@1,COG0441@2 NA|NA|NA J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) KOPIJCMJ_00580 1323361.JPOC01000062_gene2847 3.3e-23 115.2 Nocardiaceae ppk2 2.7.4.1 ko:K22468 ko00190,ko03018,map00190,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 2GKRN@201174,4FVD3@85025,COG2326@1,COG2326@2 NA|NA|NA S polyphosphate kinase KOPIJCMJ_00581 446468.Ndas_4413 2.1e-152 545.4 Streptosporangiales 1.3.8.1,1.3.8.7 ko:K00248,ko:K00249 ko00071,ko00280,ko00410,ko00640,ko00650,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map00650,map01100,map01110,map01120,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01178,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00120,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIX8@201174,4EHDP@85012,COG1960@1,COG1960@2 NA|NA|NA I Acyl-CoA dehydrogenase, middle domain KOPIJCMJ_00582 1463936.JOJI01000050_gene5841 9e-163 580.1 Actinobacteria ugd 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJQB@201174,COG1004@1,COG1004@2 NA|NA|NA M Belongs to the UDP-glucose GDP-mannose dehydrogenase family KOPIJCMJ_00583 1896.JOAU01000015_gene2030 2.1e-59 235.3 Actinobacteria purE GO:0008150,GO:0040007 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 iJN678.purE,iNJ661.Rv3275c Bacteria 2IFFD@201174,COG0041@1,COG0041@2 NA|NA|NA F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) KOPIJCMJ_00584 1504319.GM45_3340 2.2e-52 213.8 Actinobacteria Bacteria 2HZ7I@201174,COG3858@1,COG3858@2 NA|NA|NA S Glycosyl hydrolases family 18 KOPIJCMJ_00585 471852.Tcur_3874 4e-29 134.8 Streptosporangiales Bacteria 2E4AX@1,2GW4T@201174,32Z6K@2,4EJ1I@85012 NA|NA|NA S Domain of unknown function (DUF2017) KOPIJCMJ_00586 1957.JODX01000001_gene5100 7.6e-29 133.3 Actinobacteria clpS GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0050896,GO:0051087 ko:K06891 ko00000 Bacteria 2IQ3Z@201174,COG2127@1,COG2127@2 NA|NA|NA S Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation KOPIJCMJ_00587 313589.JNB_00775 4.1e-11 74.3 Intrasporangiaceae Bacteria 2HT5K@201174,4FI0R@85021,COG0455@1,COG0455@2 NA|NA|NA D bacterial-type flagellum organization KOPIJCMJ_00588 313589.JNB_00780 3.4e-91 342.4 Intrasporangiaceae ko:K02283 ko00000,ko02035,ko02044 Bacteria 2GKKJ@201174,4FGGW@85021,COG4962@1,COG4962@2 NA|NA|NA U Type II/IV secretion system protein KOPIJCMJ_00589 1385519.N801_09660 6.4e-82 310.8 Intrasporangiaceae Bacteria 2GN6E@201174,4FHCH@85021,COG4965@1,COG4965@2 NA|NA|NA U Type II secretion system (T2SS), protein F KOPIJCMJ_00590 313589.JNB_00790 4.2e-60 238.4 Intrasporangiaceae ko:K12511 ko00000,ko02044 Bacteria 2HZTC@201174,4FHX4@85021,COG2064@1,COG2064@2 NA|NA|NA NU Type II secretion system (T2SS), protein F KOPIJCMJ_00594 446471.Xcel_3428 5.2e-45 188.3 Promicromonosporaceae Bacteria 2DVVA@1,2IHH0@201174,32V07@2,4F5R6@85017 NA|NA|NA KOPIJCMJ_00595 313589.JNB_00805 1.6e-17 95.9 Intrasporangiaceae Bacteria 2GRCJ@201174,4FI3I@85021,COG4961@1,COG4961@2 NA|NA|NA U TadE-like protein KOPIJCMJ_00596 1137268.AZXF01000033_gene3448 1.7e-16 92.4 Streptosporangiales Bacteria 2AQHK@1,2I1FE@201174,31FQ6@2,4EK4S@85012 NA|NA|NA S Putative Flp pilus-assembly TadE/G-like KOPIJCMJ_00597 1035308.AQYY01000002_gene68 6.1e-28 131.7 Bacteria Bacteria COG1652@1,COG1652@2,COG3170@1,COG3170@2 NA|NA|NA S positive regulation of growth rate KOPIJCMJ_00601 649638.Trad_2836 4.4e-17 94.4 Bacteria ko:K07483,ko:K07497 ko00000 Bacteria COG2963@1,COG2963@2 NA|NA|NA L transposase activity KOPIJCMJ_00602 316274.Haur_2069 9.1e-83 313.9 Bacteria ko:K07497 ko00000 Bacteria COG2801@1,COG2801@2 NA|NA|NA L transposition KOPIJCMJ_00603 656024.FsymDg_0997 2.5e-49 201.4 Actinobacteria sdhC ko:K00241,ko:K00247 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00149,M00150,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 Bacteria 2IKU7@201174,COG2009@1,COG2009@2 NA|NA|NA C succinate dehydrogenase KOPIJCMJ_00604 105422.BBPM01000015_gene1944 1.2e-46 192.6 Streptacidiphilus sdhD ko:K00242,ko:K00246 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00149,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002 Bacteria 2GNKE@201174,2NI1D@228398,COG2142@1,COG2142@2 NA|NA|NA C Succinate dehydrogenase/Fumarate reductase transmembrane subunit KOPIJCMJ_00606 1122939.ATUD01000001_gene368 4.6e-24 118.2 Actinobacteria Bacteria 2IKC2@201174,COG3437@1,COG3437@2 NA|NA|NA T cheY-homologous receiver domain KOPIJCMJ_00607 1120934.KB894440_gene5692 0.0 1456.4 Pseudonocardiales nrdJ 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 Bacteria 2GKX9@201174,4DY0W@85010,COG0209@1,COG0209@2 NA|NA|NA F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen KOPIJCMJ_00608 469371.Tbis_2426 5.1e-55 220.7 Pseudonocardiales nrdR GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 ko:K07738 ko00000,ko03000 Bacteria 2IHU9@201174,4E2M8@85010,COG1327@1,COG1327@2 NA|NA|NA K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes KOPIJCMJ_00609 1150399.AQYK01000002_gene2473 2.6e-11 75.1 Microbacteriaceae Bacteria 2GWI9@201174,4FQ73@85023,COG1388@1,COG1388@2 NA|NA|NA M Lysin motif KOPIJCMJ_00610 1120950.KB892707_gene4592 5.9e-83 313.9 Propionibacteriales lexA GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0033554,GO:0042221,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045934,GO:0046677,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 3.4.21.88 ko:K01356 M00729 ko00000,ko00002,ko01000,ko01002,ko03400 Bacteria 2GMBN@201174,4DNCQ@85009,COG1974@1,COG1974@2 NA|NA|NA K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair KOPIJCMJ_00611 1169154.KB897780_gene2333 6e-122 444.5 Actinobacteria Bacteria 2GKEK@201174,COG4320@1,COG4320@2 NA|NA|NA K protein conserved in bacteria KOPIJCMJ_00612 471857.Svir_29270 3.4e-163 582.0 Pseudonocardiales dinG GO:0003674,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008026,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0042575,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0045004,GO:0045005,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7,3.6.4.12 ko:K02342,ko:K03722 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 2GKT8@201174,4E0JP@85010,COG1199@1,COG1199@2 NA|NA|NA KL helicase KOPIJCMJ_00613 1048339.KB913029_gene4763 4.8e-172 610.9 Frankiales hflX GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 ko:K03665 ko00000,ko03009 Bacteria 2GK55@201174,4ERJ5@85013,COG2262@1,COG2262@2 NA|NA|NA S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis KOPIJCMJ_00614 1449346.JQMO01000003_gene3598 1.6e-72 279.6 Kitasatospora dapF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 iIT341.HP0566,iLJ478.TM1522 Bacteria 2GKUD@201174,2M07M@2063,COG0253@1,COG0253@2 NA|NA|NA E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan KOPIJCMJ_00615 266940.Krad_1500 2e-76 292.7 Actinobacteria miaA GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006417,GO:0006725,GO:0006807,GO:0006950,GO:0008033,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009451,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016070,GO:0016740,GO:0016765,GO:0019222,GO:0031323,GO:0031326,GO:0032268,GO:0033554,GO:0034248,GO:0034470,GO:0034605,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0043555,GO:0044237,GO:0044238,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0051716,GO:0052381,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1990497,GO:2000112,GO:2000765 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 Bacteria 2GKFT@201174,COG0324@1,COG0324@2 NA|NA|NA J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) KOPIJCMJ_00616 66377.JOBH01000011_gene2229 2.8e-22 112.5 Actinobacteria 2.8.4.3 ko:K06168 R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 Bacteria 2GN3T@201174,COG3885@1,COG3885@2 NA|NA|NA S ferrous iron binding KOPIJCMJ_00617 471852.Tcur_3285 1.5e-195 689.1 Streptosporangiales miaB 2.8.4.3 ko:K06168 R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 Bacteria 2GJEV@201174,4EFYX@85012,COG0621@1,COG0621@2 NA|NA|NA J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine KOPIJCMJ_00618 1121272.KB903272_gene431 2.1e-33 149.1 Micromonosporales recX GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03565 ko00000,ko03400 Bacteria 2GMRF@201174,4DD5X@85008,COG2137@1,COG2137@2 NA|NA|NA S Modulates RecA activity KOPIJCMJ_00619 1380354.JIAN01000007_gene107 1.3e-161 575.9 Cellulomonadaceae recA GO:0000150,GO:0000166,GO:0000287,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009650,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0031668,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042148,GO:0042221,GO:0042623,GO:0043142,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 ko:K03553 ko03440,map03440 M00729 ko00000,ko00001,ko00002,ko03400 Bacteria 2GJ4P@201174,4F0Z7@85016,COG0468@1,COG0468@2 NA|NA|NA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage KOPIJCMJ_00620 1054860.KB913030_gene4976 0.0 1553.9 Actinobacteria lhr GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 ko:K03724 ko00000,ko01000,ko03400 Bacteria 2GJG3@201174,COG1201@1,COG1201@2 NA|NA|NA L dead DEAH box helicase KOPIJCMJ_00621 1476876.JOJO01000017_gene1354 2.8e-23 114.4 Actinobacteria clgR GO:0002682,GO:0002683,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006109,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009268,GO:0009408,GO:0009605,GO:0009607,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009894,GO:0009987,GO:0010447,GO:0010468,GO:0010556,GO:0010557,GO:0010565,GO:0010604,GO:0010628,GO:0010675,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0022611,GO:0030162,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031347,GO:0031348,GO:0032268,GO:0032502,GO:0033554,GO:0035821,GO:0040007,GO:0042176,GO:0043207,GO:0043565,GO:0043620,GO:0044003,GO:0044110,GO:0044111,GO:0044114,GO:0044115,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044413,GO:0044414,GO:0044419,GO:0045088,GO:0045824,GO:0045893,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048583,GO:0048585,GO:0050776,GO:0050777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051252,GO:0051254,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051817,GO:0051832,GO:0051833,GO:0052031,GO:0052037,GO:0052167,GO:0052170,GO:0052173,GO:0052200,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0060255,GO:0061136,GO:0062012,GO:0065007,GO:0075136,GO:0080090,GO:0080134,GO:0085016,GO:0090062,GO:0097159,GO:1901363,GO:1902680,GO:1902882,GO:1903050,GO:1903362,GO:1903506,GO:1903508,GO:2000112,GO:2001141 Bacteria 2GR3F@201174,COG1396@1,COG1396@2 NA|NA|NA K transcriptional KOPIJCMJ_00622 1122239.AULS01000007_gene453 4.3e-25 121.3 Microbacteriaceae cinA 3.5.1.42 ko:K03742,ko:K03743 ko00760,map00760 R02322 RC00100 ko00000,ko00001,ko01000 Bacteria 2IQ8T@201174,4FPN9@85023,COG1546@1,COG1546@2 NA|NA|NA S Competence-damaged protein KOPIJCMJ_00623 471852.Tcur_3305 9e-52 210.3 Streptosporangiales pgsA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 Bacteria 2GK5D@201174,4EIN9@85012,COG0558@1,COG0558@2 NA|NA|NA I CDP-alcohol phosphatidyltransferase KOPIJCMJ_00624 1120950.KB892756_gene6657 1.7e-154 552.7 Propionibacteriales rimO GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016782,GO:0018193,GO:0018197,GO:0018198,GO:0018339,GO:0019538,GO:0035596,GO:0035599,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901564 2.8.4.4 ko:K14441 R10652 RC00003,RC03217 ko00000,ko01000,ko03009 Bacteria 2GKRI@201174,4DNHY@85009,COG0621@1,COG0621@2 NA|NA|NA J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 KOPIJCMJ_00625 525368.HMPREF0591_6341 2.3e-43 181.4 Mycobacteriaceae ftsK GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 ko:K03466 ko00000,ko03036 3.A.12 Bacteria 232HU@1762,2GK3T@201174,COG1674@1,COG1674@2 NA|NA|NA D FtsK SpoIIIE KOPIJCMJ_00633 1463934.JOCF01000060_gene3408 1.4e-13 84.0 Actinobacteria Bacteria 2EGYK@1,2GRY2@201174,3493T@2 NA|NA|NA KOPIJCMJ_00635 234267.Acid_3078 1.5e-188 666.0 Bacteria Bacteria COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase activity KOPIJCMJ_00636 1122611.KB903985_gene3663 1.4e-132 479.9 Streptosporangiales 1.13.12.16 ko:K00459 ko00910,map00910 R00025 RC02541,RC02759 ko00000,ko00001,ko01000 Bacteria 2I93H@201174,4EIEF@85012,COG2070@1,COG2070@2 NA|NA|NA S 2-Nitropropane dioxygenase KOPIJCMJ_00637 1454010.JEOE01000011_gene2396 1.3e-88 334.3 Actinobacteria Bacteria 2IBWT@201174,COG4425@1,COG4425@2 NA|NA|NA S Alpha/beta-hydrolase family KOPIJCMJ_00639 290397.Adeh_2189 7.2e-36 157.9 Myxococcales Bacteria 1RAAG@1224,2WNJI@28221,2Z2RH@29,42RIX@68525,COG2030@1,COG2030@2 NA|NA|NA I MaoC like domain KOPIJCMJ_00641 358823.DF19_41840 3.4e-17 95.1 Actinobacteria ssb1 ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 ko00000,ko00001,ko03029,ko03032,ko03400 Bacteria 2IGBM@201174,COG0629@1,COG0629@2 NA|NA|NA L Single-strand binding protein family KOPIJCMJ_00642 1160718.SU9_20264 3.7e-49 201.8 Actinobacteria Bacteria 2DUVD@1,2H1X0@201174,33SHM@2 NA|NA|NA KOPIJCMJ_00645 397278.JOJN01000007_gene3349 6.5e-133 481.1 Propionibacteriales ydaM Bacteria 2GNN5@201174,4DWKW@85009,COG1215@1,COG1215@2 NA|NA|NA M Glycosyl transferase family group 2 KOPIJCMJ_00646 266117.Rxyl_2066 2e-112 413.3 Rubrobacteria oatA GO:0000271,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016020,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509 ko:K19172 ko00000,ko02048 Bacteria 2GKI5@201174,4CQDA@84995,COG1835@1,COG1835@2,COG2755@1,COG2755@2 NA|NA|NA I Acyltransferase family KOPIJCMJ_00648 1140001.I571_02495 6.7e-36 157.1 Enterococcaceae cca 2.7.7.19,2.7.7.72 ko:K00970,ko:K00974,ko:K19545 ko03013,ko03018,map03013,map03018 R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko01504,ko03016,ko03019 Bacteria 1V1W2@1239,4B2N1@81852,4HVHZ@91061,COG0617@1,COG0617@2 NA|NA|NA J Aminoglycoside-2''-adenylyltransferase KOPIJCMJ_00649 1380356.JNIK01000021_gene4538 5.3e-69 267.7 Actinobacteria glpF ko:K02440,ko:K06188 ko00000,ko02000 1.A.8,1.A.8.1,1.A.8.2 Bacteria 2GKK3@201174,COG0580@1,COG0580@2 NA|NA|NA G Belongs to the MIP aquaporin (TC 1.A.8) family KOPIJCMJ_00650 1122933.JNIY01000004_gene2358 6e-37 161.0 Cellulomonadaceae Bacteria 2I2GH@201174,4F1NA@85016,COG3583@1,COG3583@2 NA|NA|NA S G5 KOPIJCMJ_00651 710696.Intca_0624 1.4e-151 542.7 Intrasporangiaceae Bacteria 2IAMG@201174,4FFB5@85021,COG0427@1,COG0427@2 NA|NA|NA C 4-hydroxybutyrate CoA-transferase KOPIJCMJ_00652 1210045.ALNP01000002_gene4122 1.5e-64 252.7 Actinobacteria laaE Bacteria 2GMJM@201174,COG1695@1,COG1695@2 NA|NA|NA K Transcriptional regulator KOPIJCMJ_00653 649831.L083_1695 2.2e-75 289.7 Micromonosporales hemY Bacteria 2HU4W@201174,4DB7C@85008,COG1232@1,COG1232@2 NA|NA|NA H amine oxidase KOPIJCMJ_00654 446468.Ndas_2917 2.4e-18 98.2 Streptosporangiales ko:K06975 ko00000 Bacteria 2GQNP@201174,4EKDK@85012,COG2388@1,COG2388@2 NA|NA|NA S GCN5-related N-acetyl-transferase KOPIJCMJ_00655 335543.Sfum_1471 2.2e-237 828.6 Syntrophobacterales glgX 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 ko00000,ko00001,ko00002,ko01000 CBM48,GH13 Bacteria 1MU19@1224,2MQ9F@213462,2WKFS@28221,42P3J@68525,COG1523@1,COG1523@2 NA|NA|NA G Belongs to the glycosyl hydrolase 13 family KOPIJCMJ_00657 1283283.ATXA01000008_gene3121 2.3e-11 75.1 Actinobacteria rnhA 3.1.26.4,4.1.1.44 ko:K01607,ko:K03469 ko00362,ko01100,ko01120,ko01220,ko03030,map00362,map01100,map01120,map01220,map03030 R03470 RC00938 ko00000,ko00001,ko01000,ko03032 Bacteria 2IM93@201174,COG0599@1,COG0599@2 NA|NA|NA S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity KOPIJCMJ_00658 478801.Ksed_14950 9e-45 186.8 Dermacoccaceae merR2 Bacteria 1ZVW1@145357,2GM67@201174,COG0789@1,COG0789@2 NA|NA|NA K helix_turn_helix, mercury resistance KOPIJCMJ_00659 1123320.KB889679_gene2403 1e-43 182.6 Actinobacteria yitW ko:K02612 ko00360,ko01120,map00360,map01120 R09838 RC02690 ko00000,ko00001 Bacteria 2IKUH@201174,COG2151@1,COG2151@2 NA|NA|NA J metal-sulfur cluster biosynthetic enzyme KOPIJCMJ_00660 1537715.JQFJ01000005_gene249 4.1e-61 240.7 Sphingomonadales ahcY GO:0000096,GO:0000097,GO:0000098,GO:0000166,GO:0001666,GO:0002376,GO:0002437,GO:0002439,GO:0002544,GO:0003674,GO:0003824,GO:0004013,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006152,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0006950,GO:0006952,GO:0006954,GO:0006955,GO:0007584,GO:0007610,GO:0007622,GO:0007623,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009087,GO:0009116,GO:0009119,GO:0009164,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016053,GO:0016054,GO:0016787,GO:0016801,GO:0016802,GO:0017076,GO:0017144,GO:0019439,GO:0019510,GO:0019752,GO:0019899,GO:0022610,GO:0030260,GO:0030312,GO:0030554,GO:0031667,GO:0033353,GO:0034641,GO:0034655,GO:0034656,GO:0035375,GO:0035635,GO:0036094,GO:0036293,GO:0040007,GO:0042219,GO:0042221,GO:0042278,GO:0042454,GO:0042745,GO:0042802,GO:0042995,GO:0043005,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0044650,GO:0046085,GO:0046128,GO:0046130,GO:0046394,GO:0046395,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0046700,GO:0048037,GO:0048511,GO:0048512,GO:0050662,GO:0050667,GO:0050896,GO:0051186,GO:0051187,GO:0051287,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0055086,GO:0070403,GO:0070482,GO:0071268,GO:0071704,GO:0071944,GO:0072521,GO:0072523,GO:0097159,GO:0097458,GO:0098604,GO:0120025,GO:1901135,GO:1901136,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1901657,GO:1901658 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 Bacteria 1MUQ2@1224,2K0R8@204457,2TSJY@28211,COG0499@1,COG0499@2 NA|NA|NA H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine KOPIJCMJ_00661 1125971.ASJB01000080_gene7656 1.3e-51 210.3 Pseudonocardiales Bacteria 2H4MP@201174,4E2SC@85010,COG1714@1,COG1714@2 NA|NA|NA S RDD family KOPIJCMJ_00662 1122611.KB903946_gene708 1.8e-96 359.4 Streptosporangiales ko:K06384 ko00000 Bacteria 2GJTG@201174,4EH4Y@85012,COG1300@1,COG1300@2 NA|NA|NA S Stage II sporulation protein M KOPIJCMJ_00663 208444.JNYY01000029_gene1055 1.8e-115 422.9 Pseudonocardiales Bacteria 2GK9A@201174,4DXK9@85010,COG1721@1,COG1721@2 NA|NA|NA S Protein of unknown function DUF58 KOPIJCMJ_00664 1449346.JQMO01000003_gene5361 2.8e-134 485.0 Kitasatospora moxR2 ko:K03924 ko00000,ko01000 Bacteria 2GK07@201174,2M108@2063,COG0714@1,COG0714@2 NA|NA|NA S ATPase family associated with various cellular activities (AAA) KOPIJCMJ_00665 1123320.KB889749_gene4532 1.2e-54 220.7 Actinobacteria GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 29B69@1,2GKQW@201174,2ZY4N@2 NA|NA|NA KOPIJCMJ_00666 1089545.KB913037_gene5605 3.1e-38 165.2 Pseudonocardiales Bacteria 2CT9V@1,2GKR6@201174,32SSX@2,4E4EE@85010 NA|NA|NA S Domain of unknown function (DUF4129) KOPIJCMJ_00667 68199.JNZO01000032_gene4153 1e-32 147.9 Actinobacteria CP_0034 ko:K02417,ko:K02519 ko02030,ko02040,map02030,map02040 ko00000,ko00001,ko02035,ko02044,ko03012,ko03029 3.A.6.2,3.A.6.3 Bacteria 2GKJ7@201174,COG5180@1,COG5180@2 NA|NA|NA A pathogenesis KOPIJCMJ_00668 1211815.CBYP010000043_gene3449 4e-29 135.2 Frankiales ctsW ko:K02242 M00429 ko00000,ko00002,ko02044 Bacteria 2I9PA@201174,4ET02@85013,COG1040@1,COG1040@2 NA|NA|NA S phosphoribosyltransferase KOPIJCMJ_00669 743718.Isova_2354 2.9e-44 185.3 Promicromonosporaceae hpf GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113 ko:K05808 ko00000,ko03009 Bacteria 2GMYF@201174,4F3CD@85017,COG1544@1,COG1544@2 NA|NA|NA J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase KOPIJCMJ_00670 251221.35211133 2.8e-18 99.0 Cyanobacteria ko:K02479 ko00000,ko02022 Bacteria 1G18B@1117,COG2197@1,COG2197@2 NA|NA|NA K PFAM Response regulator receiver domain KOPIJCMJ_00671 1089455.MOPEL_003_00860 1.8e-58 232.6 Dermatophilaceae fnlB 1.1.1.367 ko:K19068 ko00000,ko01000 Bacteria 2HJI9@201174,4F6P2@85018,COG0451@1,COG0451@2,COG1898@1,COG1898@2 NA|NA|NA GM NAD dependent epimerase/dehydratase family KOPIJCMJ_00672 313589.JNB_18023 1.7e-138 499.2 Intrasporangiaceae wecB 5.1.3.14 ko:K01791 ko00520,ko01100,ko05111,map00520,map01100,map05111 M00362 R00420 RC00290 ko00000,ko00001,ko00002,ko01000,ko01005 Bacteria 2GJWS@201174,4FG1P@85021,COG0381@1,COG0381@2 NA|NA|NA M Belongs to the UDP-N-acetylglucosamine 2-epimerase family KOPIJCMJ_00673 1032480.MLP_34460 1.2e-50 207.2 Propionibacteriales Bacteria 28MCN@1,2GXXM@201174,2ZAQR@2,4DW15@85009 NA|NA|NA KOPIJCMJ_00677 1122236.KB905144_gene2309 4.8e-123 448.7 Nitrosomonadales Bacteria 1MU2C@1224,2KNM3@206350,2VIDG@28216,COG5001@1,COG5001@2 NA|NA|NA T Putative diguanylate phosphodiesterase KOPIJCMJ_00678 1120950.KB892741_gene2670 5.4e-258 896.7 Propionibacteriales ilvD GO:0003674,GO:0003824,GO:0004160,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJIJ@201174,4DNV7@85009,COG0129@1,COG0129@2 NA|NA|NA EG Belongs to the IlvD Edd family KOPIJCMJ_00679 1121946.AUAX01000019_gene7777 9.7e-63 246.9 Actinobacteria Bacteria 2ISWE@201174,COG3340@1,COG3340@2 NA|NA|NA E Peptidase family S51 KOPIJCMJ_00680 351607.Acel_2052 2.6e-65 256.1 Actinobacteria 3.4.13.21,3.4.15.6 ko:K05995,ko:K13282 R09722 RC00064,RC00141 ko00000,ko01000,ko01002 Bacteria 2I98G@201174,COG0215@1,COG0215@2,COG4242@1,COG4242@2 NA|NA|NA J Belongs to the peptidase S51 family KOPIJCMJ_00681 1463825.JNXC01000005_gene2483 2.9e-49 201.8 Pseudonocardiales bioY ko:K02014,ko:K03523 ko02010,map02010 M00581,M00582 ko00000,ko00001,ko00002,ko02000 1.B.14,2.A.88.1,2.A.88.2 Bacteria 2GJ53@201174,4E2ZE@85010,COG1268@1,COG1268@2 NA|NA|NA S BioY family KOPIJCMJ_00682 1463900.JOIX01000008_gene7573 3.2e-159 568.2 Actinobacteria gatB GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 Bacteria 2GJJH@201174,COG0064@1,COG0064@2 NA|NA|NA J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) KOPIJCMJ_00683 479433.Caci_6678 4.5e-134 485.0 Actinobacteria Bacteria 2GIUM@201174,COG0477@1,COG0477@2 NA|NA|NA EGP Major facilitator superfamily KOPIJCMJ_00684 1121946.AUAX01000004_gene744 7.2e-17 94.4 Micromonosporales Bacteria 2GKW3@201174,4DDW4@85008,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family KOPIJCMJ_00685 471853.Bcav_0362 1.2e-18 100.5 Actinobacteria ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2IRIX@201174,COG1277@1,COG1277@2 NA|NA|NA S ABC-type transport system involved in multi-copper enzyme maturation permease component KOPIJCMJ_00686 298655.KI912266_gene5611 1.4e-74 286.6 Frankiales ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GN8P@201174,4EV93@85013,COG1131@1,COG1131@2 NA|NA|NA V ABC transporter KOPIJCMJ_00687 570268.ANBB01000050_gene4013 1.9e-56 226.5 Actinobacteria Bacteria 2GKV2@201174,COG4585@1,COG4585@2 NA|NA|NA T Histidine kinase KOPIJCMJ_00688 1205910.B005_1121 1.4e-93 350.1 Streptosporangiales amiA ko:K01436,ko:K06048 ko00000,ko01000,ko01002 Bacteria 2GK05@201174,4EHXK@85012,COG1473@1,COG1473@2 NA|NA|NA S Peptidase dimerisation domain KOPIJCMJ_00689 926569.ANT_20770 3.1e-16 90.9 Chloroflexi mrx1 1.20.4.3 ko:K18917 ko00000,ko01000 Bacteria 2G75B@200795,COG0695@1,COG0695@2 NA|NA|NA O Glutathione S-transferase, N-terminal domain KOPIJCMJ_00690 1121017.AUFG01000020_gene2298 2.4e-37 161.8 Intrasporangiaceae dcdA 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 Bacteria 2IJ94@201174,4FHCM@85021,COG2131@1,COG2131@2 NA|NA|NA F MafB19-like deaminase KOPIJCMJ_00691 1306174.JODP01000001_gene5170 1.7e-50 206.5 Actinobacteria yeaD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716 4.2.1.9,5.1.3.15 ko:K01687,ko:K01792 ko00010,ko00290,ko00770,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00010,map00290,map00770,map01100,map01110,map01120,map01130,map01210,map01230 M00019,M00570 R01209,R02739,R04441,R05070 RC00468,RC00563,RC01714 ko00000,ko00001,ko00002,ko01000 Bacteria 2IIUH@201174,COG0676@1,COG0676@2 NA|NA|NA G Belongs to the glucose-6-phosphate 1-epimerase family KOPIJCMJ_00692 1305732.JAGG01000001_gene909 1.2e-108 401.0 Actinobacteria ykoD 3.6.3.24 ko:K02031,ko:K02032,ko:K10824,ko:K15587,ko:K16785,ko:K16786,ko:K16787 ko02010,ko02024,map02010,map02024 M00239,M00440,M00582 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35,3.A.1.5 Bacteria 2I2G4@201174,COG0619@1,COG0619@2,COG1123@1,COG4172@2 NA|NA|NA P Cobalt transport protein KOPIJCMJ_00693 1122182.KB903816_gene1683 1.1e-53 216.5 Micromonosporales ykoE ko:K16925 M00582 ko00000,ko00002,ko02000 3.A.1.30 Bacteria 2IDAN@201174,4D9S6@85008,COG4721@1,COG4721@2 NA|NA|NA S ABC-type cobalt transport system, permease component KOPIJCMJ_00694 2002.JOEQ01000009_gene6516 1.6e-62 246.1 Streptosporangiales yplQ ko:K11068 ko00000,ko02042 Bacteria 2GJGQ@201174,4EIGX@85012,COG1272@1,COG1272@2 NA|NA|NA S Haemolysin-III related KOPIJCMJ_00695 411459.RUMOBE_00192 7.4e-11 73.2 Blautia Bacteria 1VEJY@1239,24QJW@186801,3Y0K2@572511,COG3326@1,COG3326@2 NA|NA|NA S Psort location CytoplasmicMembrane, score KOPIJCMJ_00696 195250.CM001776_gene511 1.5e-76 293.1 Synechococcus 1.1.1.219 ko:K00091 ko00000,ko01000 Bacteria 1G2DP@1117,1H3Z1@1129,COG0451@1,COG0451@2 NA|NA|NA M NmrA-like family KOPIJCMJ_00698 1172188.KB911821_gene1996 9.1e-155 553.9 Intrasporangiaceae Bacteria 2HXIC@201174,4FH0P@85021,COG0471@1,COG0471@2 NA|NA|NA P Sodium:sulfate symporter transmembrane region KOPIJCMJ_00699 326424.FRAAL6407 8.7e-153 547.4 Frankiales atzF 3.5.1.54 ko:K01457 ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120 R00005 RC02756 ko00000,ko00001,ko01000 Bacteria 2GSBS@201174,4ERN1@85013,COG0154@1,COG0154@2,COG2105@1,COG2105@2 NA|NA|NA J Amidase KOPIJCMJ_00700 365528.KB891208_gene2813 2.9e-107 394.8 Frankiales rutB Bacteria 2I9AW@201174,4ERJC@85013,COG1335@1,COG1335@2 NA|NA|NA Q PFAM Isochorismatase KOPIJCMJ_00701 634500.EbC_35210 1.6e-09 68.2 Gammaproteobacteria rutB 3.5.1.110 ko:K09020 ko00240,ko01100,map00240,map01100 R09947,R09980 RC02737,RC02738 ko00000,ko00001,ko01000 Bacteria 1MV0W@1224,1RU8R@1236,COG1335@1,COG1335@2 NA|NA|NA Q Amidases related to nicotinamidase KOPIJCMJ_00702 337191.KTR9_4794 6.8e-61 241.1 Actinobacteria ko:K03496 ko00000,ko03036,ko04812 Bacteria 2IHZI@201174,COG1192@1,COG1192@2 NA|NA|NA D PFAM Cobyrinic acid a,c-diamide synthase KOPIJCMJ_00705 196162.Noca_4737 2.4e-64 253.8 Bacteria Bacteria 2EWQ2@1,33Q1X@2 NA|NA|NA KOPIJCMJ_00707 710696.Intca_3502 1.6e-31 141.7 Intrasporangiaceae 2.3.1.15 ko:K08591,ko:K19159 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004,ko02048 Bacteria 2GRC8@201174,4FJ8S@85021,COG2161@1,COG2161@2 NA|NA|NA D Antitoxin component of a toxin-antitoxin (TA) module KOPIJCMJ_00708 710696.Intca_3501 4.3e-32 143.7 Intrasporangiaceae ko:K06218 ko00000,ko02048 Bacteria 2GRQR@201174,4FJ7R@85021,COG2026@1,COG2026@2 NA|NA|NA DJ ParE toxin of type II toxin-antitoxin system, parDE KOPIJCMJ_00709 1048339.KB913029_gene158 2.2e-28 133.3 Frankiales Bacteria 2IHBR@201174,4EW9H@85013,COG0741@1,COG0741@2,COG3103@1,COG4991@2 NA|NA|NA MT Transglycosylase SLT domain KOPIJCMJ_00710 1449976.KALB_374 2.8e-09 68.9 Pseudonocardiales Bacteria 2IFSD@201174,4E6ND@85010,COG1476@1,COG1476@2 NA|NA|NA K transcriptional regulators KOPIJCMJ_00711 1101188.KI912157_gene288 6.2e-14 83.6 Actinobacteria Bacteria 2BH0A@1,2GUIE@201174,32B0E@2 NA|NA|NA KOPIJCMJ_00713 1169161.KB897725_gene1728 1.2e-62 246.1 Actinobacteria hit GO:0003674,GO:0003824,GO:0003877,GO:0004551,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008796,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009987,GO:0015959,GO:0015961,GO:0015965,GO:0015967,GO:0016020,GO:0016462,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0070566,GO:0071704,GO:0071944,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 2.7.7.53 ko:K19710 ko00230,map00230 R00126,R01618 RC00002,RC02753,RC02795 ko00000,ko00001,ko01000 Bacteria 2GJT5@201174,COG0537@1,COG0537@2 NA|NA|NA FG Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases KOPIJCMJ_00714 1122138.AQUZ01000001_gene1498 6e-280 969.9 Propionibacteriales thrS GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 2GKTC@201174,4DN38@85009,COG0441@1,COG0441@2 NA|NA|NA J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) KOPIJCMJ_00715 1108045.GORHZ_135_00210 1.1e-121 443.4 Gordoniaceae acrA1_1 Bacteria 2I2PV@201174,4GAW1@85026,COG3320@1,COG3320@2 NA|NA|NA M Male sterility protein KOPIJCMJ_00716 196162.Noca_1668 2e-270 938.3 Actinobacteria GO:0000041,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0006826,GO:0008150,GO:0008152,GO:0008823,GO:0015677,GO:0015682,GO:0016020,GO:0016021,GO:0016491,GO:0016722,GO:0016723,GO:0030001,GO:0031224,GO:0031226,GO:0033216,GO:0034220,GO:0034755,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0052851,GO:0055085,GO:0055114,GO:0071944,GO:0072512,GO:0097286,GO:0098655,GO:0098657,GO:0098659,GO:0098660,GO:0098662,GO:0098706,GO:0098711,GO:0098739,GO:0099587 1.2.1.80 ko:K14330 ko00000,ko01000 Bacteria 2IEVX@201174,COG5322@1,COG5322@2 NA|NA|NA S oxidoreductase activity KOPIJCMJ_00717 1386089.N865_13575 9.6e-39 166.8 Intrasporangiaceae Bacteria 2EH65@1,2I75W@201174,33AY1@2,4FH3V@85021 NA|NA|NA S Domain of unknown function (DUF1876) KOPIJCMJ_00720 471852.Tcur_2049 8.3e-23 114.0 Streptosporangiales Bacteria 2EQY7@1,2I34U@201174,33IHV@2,4ER5N@85012 NA|NA|NA S Putative transmembrane protein (PGPGW) KOPIJCMJ_00721 67257.JODR01000017_gene4448 2.5e-26 125.2 Actinobacteria ssgB GO:0000003,GO:0000910,GO:0005575,GO:0005618,GO:0005623,GO:0007049,GO:0008150,GO:0009653,GO:0009987,GO:0010564,GO:0010927,GO:0016043,GO:0019954,GO:0022402,GO:0022607,GO:0030154,GO:0030312,GO:0030428,GO:0030435,GO:0030436,GO:0030447,GO:0030448,GO:0031160,GO:0032465,GO:0032467,GO:0032502,GO:0032506,GO:0032989,GO:0032991,GO:0040007,GO:0042244,GO:0042546,GO:0043934,GO:0043936,GO:0044085,GO:0044457,GO:0044464,GO:0045229,GO:0045787,GO:0048518,GO:0048522,GO:0048646,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0051301,GO:0051302,GO:0051726,GO:0051781,GO:0065007,GO:0070590,GO:0070726,GO:0071554,GO:0071555,GO:0071840,GO:0071944,GO:0090068,GO:0090529,GO:1903664,GO:1903666,GO:1990586,GO:2000241,GO:2000243,GO:2000244,GO:2000246 Bacteria 2IFE3@201174,32RFA@2,arCOG03175@1 NA|NA|NA S sporulation resulting in formation of a cellular spore KOPIJCMJ_00722 1003195.SCAT_5281 5.2e-71 274.6 Actinobacteria 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 2GN5Z@201174,COG0115@1,COG0115@2 NA|NA|NA EH Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase KOPIJCMJ_00723 1172180.KB911785_gene337 2e-122 445.7 Actinobacteria pabB 2.6.1.85,4.1.3.27,4.1.3.38 ko:K01665,ko:K03342,ko:K13503,ko:K13950 ko00400,ko00790,ko01100,ko01110,ko01130,ko01230,map00400,map00790,map01100,map01110,map01130,map01230 M00023 R00985,R00986,R01716,R05553 RC00010,RC01418,RC01843,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 2GN7D@201174,COG0147@1,COG0147@2 NA|NA|NA EH PFAM chorismate KOPIJCMJ_00727 1386089.N865_12705 4.4e-35 154.1 Intrasporangiaceae crcB ko:K06199 ko00000,ko02000 1.A.43.1,1.A.43.2,1.A.43.3 Bacteria 2HGGD@201174,4FHJ1@85021,COG0239@1,COG0239@2 NA|NA|NA U Important for reducing fluoride concentration in the cell, thus reducing its toxicity KOPIJCMJ_00728 1068978.AMETH_3074 3e-43 181.0 Pseudonocardiales ko:K09137 ko00000 Bacteria 2IM7J@201174,4E77D@85010,COG1993@1,COG1993@2 NA|NA|NA S Uncharacterized ACR, COG1993 KOPIJCMJ_00729 1120950.KB892768_gene5293 7.5e-29 133.7 Propionibacteriales crcB2 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 ko:K06199 ko00000,ko02000 1.A.43.1,1.A.43.2,1.A.43.3 Bacteria 2IKM1@201174,4DSBC@85009,COG0239@1,COG0239@2 NA|NA|NA D Important for reducing fluoride concentration in the cell, thus reducing its toxicity KOPIJCMJ_00730 1278308.KB907074_gene586 2.8e-38 165.2 Microbacteriaceae Bacteria 2IHZ7@201174,4FNK0@85023,COG0262@1,COG0262@2 NA|NA|NA H RibD C-terminal domain KOPIJCMJ_00731 1246448.ANAZ01000044_gene1247 8.5e-82 310.1 Streptosporangiales Bacteria 2GV75@201174,4EK64@85012,COG1309@1,COG1309@2 NA|NA|NA K Tetracyclin repressor, C-terminal all-alpha domain KOPIJCMJ_00732 1246448.ANAZ01000005_gene5141 9.2e-106 390.2 Streptosporangiales Bacteria 2GIS3@201174,4EHU0@85012,COG0604@1,COG0604@2 NA|NA|NA C Zinc-binding dehydrogenase KOPIJCMJ_00733 593907.Celgi_2506 2.1e-95 355.5 Actinobacteria Bacteria 2GMD7@201174,COG1305@1,COG1305@2 NA|NA|NA E transglutaminase KOPIJCMJ_00734 391037.Sare_2910 2.7e-61 241.9 Actinobacteria Bacteria 2C7PT@1,2I886@201174,2ZCBY@2 NA|NA|NA KOPIJCMJ_00735 1133849.O3I_037875 3.1e-59 235.3 Nocardiaceae Bacteria 2HH54@201174,4G3S3@85025,COG1309@1,COG1309@2 NA|NA|NA K Tetracyclin repressor, C-terminal all-alpha domain KOPIJCMJ_00736 765420.OSCT_0070 8.1e-38 164.1 Chloroflexia Bacteria 28IZQ@1,2GA1E@200795,2Z8X1@2,377NY@32061 NA|NA|NA S Domain of unknown function (DUF4386) KOPIJCMJ_00737 251221.35212019 4.2e-13 80.1 Cyanobacteria fieF Bacteria 1G0RT@1117,COG0053@1,COG0053@2 NA|NA|NA P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family KOPIJCMJ_00738 1123322.KB904635_gene2587 1e-110 406.8 Actinobacteria drrA3 ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GIY8@201174,COG1131@1,COG1131@2 NA|NA|NA V ABC transporter KOPIJCMJ_00739 1463845.JOIG01000003_gene4753 3.3e-80 305.1 Actinobacteria ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GKJF@201174,COG0842@1,COG0842@2 NA|NA|NA V transport, permease protein KOPIJCMJ_00743 512565.AMIS_48700 5.3e-114 417.9 Micromonosporales macB ko:K02004,ko:K05685 ko02010,map02010 M00258,M00709 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.122.1,3.A.1.122.12 Bacteria 2GIRW@201174,4D8TU@85008,COG0577@1,COG0577@2 NA|NA|NA V MacB-like periplasmic core domain KOPIJCMJ_00744 1123320.KB889562_gene6766 9e-82 310.1 Actinobacteria ko:K02003 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GK3I@201174,COG1136@1,COG1136@2 NA|NA|NA V ABC transporter KOPIJCMJ_00745 479432.Sros_8876 3.8e-29 136.3 Streptosporangiales hlyD3 ko:K02005,ko:K13888 M00709 ko00000,ko00002,ko02000 8.A.1 Bacteria 2H154@201174,4EGKC@85012,COG0845@1,COG0845@2 NA|NA|NA M HlyD family secretion protein KOPIJCMJ_00746 512565.AMIS_33730 5.3e-09 67.0 Micromonosporales ko:K00375 ko00000,ko03000 Bacteria 2GITW@201174,4D9DH@85008,COG1167@1,COG1167@2 NA|NA|NA K Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs KOPIJCMJ_00747 351607.Acel_0388 4.9e-08 62.4 Frankiales icd GO:0000287,GO:0003674,GO:0003824,GO:0004448,GO:0004450,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006102,GO:0008150,GO:0008152,GO:0008270,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0016999,GO:0017144,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044464,GO:0045333,GO:0046487,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:0072350 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GM3D@201174,4ERFE@85013,COG0538@1,COG0538@2 NA|NA|NA C Belongs to the isocitrate and isopropylmalate dehydrogenases family KOPIJCMJ_00748 367299.JOEE01000007_gene23 8.8e-73 280.4 Intrasporangiaceae exoA 3.1.11.2 ko:K01142 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 2GKIS@201174,4FEP7@85021,COG0708@1,COG0708@2 NA|NA|NA L exodeoxyribonuclease III KOPIJCMJ_00749 1122138.AQUZ01000084_gene8782 3.9e-126 458.4 Propionibacteriales ytfL GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03699 ko00000,ko02042 Bacteria 2GKN5@201174,4DPDV@85009,COG1253@1,COG1253@2 NA|NA|NA S Transporter associated domain KOPIJCMJ_00750 1150864.MILUP08_40848 6.8e-123 447.2 Micromonosporales trpS GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 2GJ9A@201174,4DAKB@85008,COG0180@1,COG0180@2 NA|NA|NA J Tryptophanyl-tRNA synthetase KOPIJCMJ_00751 266940.Krad_3968 1e-43 183.3 Actinobacteria Bacteria 2GRF0@201174,COG1514@1,COG1514@2 NA|NA|NA J 2'-5' RNA ligase KOPIJCMJ_00752 1157637.KB892155_gene7597 2.1e-72 279.3 Actinobacteria speE 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 Bacteria 2GN8I@201174,COG0421@1,COG0421@2 NA|NA|NA E spermidine synthase KOPIJCMJ_00753 1101188.KI912155_gene948 1.3e-42 179.1 Micrococcaceae 1.8.1.9 ko:K00384,ko:K03671 ko00450,ko04621,ko05418,map00450,map04621,map05418 R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000,ko03110 Bacteria 1W9G6@1268,2IKP1@201174,COG0526@1,COG0526@2 NA|NA|NA CO Belongs to the thioredoxin family KOPIJCMJ_00754 66869.JNXG01000005_gene2143 1.3e-17 97.8 Streptomyces griseus group ko:K13582 ko04112,map04112 ko00000,ko00001 Bacteria 2GPMH@201174,417NJ@629295,COG3206@1,COG3206@2 NA|NA|NA M Domain of unknown function (DUF4349) KOPIJCMJ_00755 1306174.JODP01000029_gene3831 3.3e-30 138.7 Actinobacteria ko:K03088 ko00000,ko03021 Bacteria 2IK5Q@201174,COG1595@1,COG1595@2 NA|NA|NA K belongs to the sigma-70 factor family, ECF subfamily KOPIJCMJ_00756 471852.Tcur_2229 5.2e-51 207.2 Streptosporangiales iscU ko:K04488 ko00000 Bacteria 2IHY9@201174,4EIUC@85012,COG0822@1,COG0822@2 NA|NA|NA C NifU-like N terminal domain KOPIJCMJ_00757 471852.Tcur_2228 5e-163 580.9 Streptosporangiales sufS GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 Bacteria 2GIVK@201174,4EHYF@85012,COG0520@1,COG0520@2 NA|NA|NA E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine KOPIJCMJ_00758 1155714.KB891988_gene2109 5.3e-112 410.6 Actinobacteria sufC ko:K09013 ko00000,ko02000 Bacteria 2GKB7@201174,COG0396@1,COG0396@2 NA|NA|NA O FeS assembly ATPase SufC KOPIJCMJ_00759 1944.JOAZ01000005_gene1991 4.5e-30 137.1 Streptomyces griseus group hcaC ko:K05710 ko00360,ko01120,ko01220,map00360,map01120,map01220 M00545 R06782,R06783 RC00098 br01602,ko00000,ko00001,ko00002 Bacteria 2IQK7@201174,41AUI@629295,COG2146@1,COG2146@2 NA|NA|NA P Rieske-like [2Fe-2S] domain KOPIJCMJ_00761 351607.Acel_1135 5.2e-181 640.6 Frankiales sufB ko:K07033,ko:K09014 ko00000 Bacteria 2GKCZ@201174,4ERKY@85013,COG0719@1,COG0719@2 NA|NA|NA O TIGRFAM FeS assembly protein SufB KOPIJCMJ_00762 408672.NBCG_01400 8.7e-71 274.6 Propionibacteriales 3.2.1.26 ko:K01193 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00801,R00802,R02410,R03635,R03921,R06088 RC00028,RC00077 ko00000,ko00001,ko01000 GH32 Bacteria 2GJ9T@201174,4DS6H@85009,COG1621@1,COG1621@2 NA|NA|NA G Glycosyl hydrolases family 32 KOPIJCMJ_00763 1254432.SCE1572_10845 1.8e-156 559.7 Myxococcales kup ko:K03549 ko00000,ko02000 2.A.72 Bacteria 1MUVH@1224,2WJEH@28221,2YXPN@29,42P5Y@68525,COG3158@1,COG3158@2 NA|NA|NA P Transport of potassium into the cell KOPIJCMJ_00764 479435.Kfla_0169 1.9e-27 130.2 Propionibacteriales 2.7.6.5 ko:K07816 ko00230,map00230 R00429 RC00002,RC00078 ko00000,ko00001,ko01000 Bacteria 2GKF8@201174,4DPS6@85009,COG2357@1,COG2357@2 NA|NA|NA Q Region found in RelA / SpoT proteins KOPIJCMJ_00765 1108045.GORHZ_125_00320 5.7e-187 660.6 Gordoniaceae 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 Bacteria 2GIUC@201174,4GBU2@85026,COG0318@1,COG0318@2 NA|NA|NA IQ AMP-binding enzyme C-terminal domain KOPIJCMJ_00766 1123322.KB904713_gene5220 1.8e-133 482.6 Actinobacteria 1.18.1.3,1.7.1.15 ko:K00362,ko:K00529 ko00071,ko00360,ko00910,ko01120,ko01220,map00071,map00360,map00910,map01120,map01220 M00530,M00545 R00787,R02000,R06782,R06783 RC00098,RC00176 br01602,ko00000,ko00001,ko00002,ko01000 Bacteria 2GJKT@201174,COG0446@1,COG0446@2 NA|NA|NA Q pyridine nucleotide-disulphide oxidoreductase KOPIJCMJ_00767 1121017.AUFG01000019_gene2370 2.6e-55 223.4 Intrasporangiaceae ko:K14645 ko02024,map02024 ko00000,ko00001,ko01000,ko01002,ko03110 Bacteria 2GIRE@201174,4FGR4@85021,COG1404@1,COG1404@2 NA|NA|NA O Subtilase family KOPIJCMJ_00768 1032480.MLP_04950 8.2e-53 214.2 Propionibacteriales tagH 3.1.3.5,3.1.3.6,3.1.4.16 ko:K01081,ko:K01119 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 R00183,R00511,R00963,R01126,R01227,R01562,R01569,R01664,R01877,R01968,R02088,R02102,R02148,R02323,R02370,R02719,R03346,R03537,R03538,R03929,R05135 RC00017,RC00078,RC00296 ko00000,ko00001,ko01000 Bacteria 2I3RJ@201174,4DR7V@85009,COG3103@1,COG3103@2 NA|NA|NA T sh3 domain protein KOPIJCMJ_00769 1210045.ALNP01000035_gene2435 1.5e-88 333.2 Actinobacteria Bacteria 2GJ8E@201174,COG5282@1,COG5282@2 NA|NA|NA S protein, coenzyme F420 biosynthesis associated KOPIJCMJ_00770 1906.SFRA_18710 8.7e-63 248.1 Actinobacteria dacB 3.4.16.4 ko:K07259 ko00550,map00550 ko00000,ko00001,ko01000,ko01002,ko01011 Bacteria 2GJPH@201174,COG2027@1,COG2027@2 NA|NA|NA M D-alanyl-D-alanine carboxypeptidase KOPIJCMJ_00771 66429.JOFL01000013_gene2959 6.5e-74 283.5 Actinobacteria ppa GO:0000287,GO:0003674,GO:0003824,GO:0004427,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0071944 3.6.1.1 ko:K01507 ko00190,map00190 ko00000,ko00001,ko01000 iNJ661.Rv3628 Bacteria 2GM7F@201174,COG0221@1,COG0221@2 NA|NA|NA C Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions KOPIJCMJ_00772 1110697.NCAST_20_05770 7.5e-59 233.8 Nocardiaceae Bacteria 2IJG5@201174,4FVR0@85025,COG5587@1,COG5587@2 NA|NA|NA S Conserved hypothetical protein (DUF2461) KOPIJCMJ_00773 1283283.ATXA01000005_gene2041 8.4e-190 670.6 Frankiales Bacteria 2GK30@201174,4ES04@85013,COG3973@1,COG3973@2 NA|NA|NA L DNA helicase KOPIJCMJ_00774 40571.JOEA01000010_gene3037 3.6e-73 281.6 Pseudonocardiales ycbB ko:K00786 ko00000,ko01000 Bacteria 2I2J1@201174,4DXD3@85010,COG1216@1,COG1216@2 NA|NA|NA S Glycosyl transferase family 2 KOPIJCMJ_00775 1449044.JMLE01000005_gene690 1.4e-15 89.4 Actinobacteria XK27_09090 ko:K09153 ko00000 Bacteria 2GQZ0@201174,COG2456@1,COG2456@2 NA|NA|NA S Uncharacterized conserved protein (DUF2304) KOPIJCMJ_00776 477641.MODMU_2240 2.1e-81 309.7 Frankiales Bacteria 2GN4Y@201174,4ETWR@85013,COG0628@1,COG0628@2 NA|NA|NA S AI-2E family transporter KOPIJCMJ_00777 1121272.KB903249_gene2575 5.3e-45 188.0 Micromonosporales mpg GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.2.2.21 ko:K03652 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 2GNW1@201174,4DD25@85008,COG2094@1,COG2094@2 NA|NA|NA L Belongs to the DNA glycosylase MPG family KOPIJCMJ_00778 32049.SYNPCC7002_A1469 4.9e-38 164.5 Synechococcus GO:0005575,GO:0005576,GO:0005615,GO:0044421 Bacteria 1G6R4@1117,1H17A@1129,COG2335@1,COG2335@2 NA|NA|NA M Fasciclin domain protein KOPIJCMJ_00779 68570.DC74_256 1.6e-116 426.0 Actinobacteria ppk2 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005525,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006183,GO:0006464,GO:0006468,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009889,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0030808,GO:0031323,GO:0031326,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0036211,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044403,GO:0044419,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046777,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051704,GO:0055086,GO:0062012,GO:0065007,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0080090,GO:0090407,GO:0097159,GO:0097367,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.4.1 ko:K22468 ko00190,ko03018,map00190,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 2GKRN@201174,COG2326@1,COG2326@2 NA|NA|NA G polyphosphate kinase KOPIJCMJ_00780 1394178.AWOO02000034_gene8339 2.1e-137 496.9 Streptosporangiales Bacteria 2GJAR@201174,4EG63@85012,COG2909@1,COG2909@2 NA|NA|NA K AAA ATPase domain KOPIJCMJ_00782 58123.JOFJ01000012_gene5336 1.5e-31 144.1 Streptosporangiales Bacteria 2IBIC@201174,4EH95@85012,COG2199@1,COG3706@2 NA|NA|NA T diguanylate cyclase KOPIJCMJ_00783 397278.JOJN01000001_gene2848 2.2e-81 309.7 Propionibacteriales Bacteria 2I9AH@201174,4DMZA@85009,COG1403@1,COG1403@2 NA|NA|NA V HNH nucleases KOPIJCMJ_00788 1033730.CAHG01000008_gene3077 1.3e-113 417.5 Actinobacteria 3.2.1.14 ko:K01183 ko00520,ko01100,map00520,map01100 R01206,R02334 RC00467 ko00000,ko00001,ko01000 GH18 Bacteria 2IGIW@201174,COG3325@1,COG3325@2 NA|NA|NA G Belongs to the glycosyl hydrolase 18 family KOPIJCMJ_00789 67352.JODS01000020_gene3992 7.1e-70 270.8 Actinobacteria spoU2 2.1.1.185 ko:K03218,ko:K03437 ko00000,ko01000,ko03009,ko03016 Bacteria 2GJ12@201174,COG0566@1,COG0566@2 NA|NA|NA J rRNA methyltransferase KOPIJCMJ_00790 1123251.ATWM01000010_gene2980 3.7e-88 331.6 Intrasporangiaceae qmcA Bacteria 2GJ1U@201174,4FFBS@85021,COG0330@1,COG0330@2 NA|NA|NA O prohibitin homologues KOPIJCMJ_00791 465541.ATCJ01000005_gene2581 2.2e-27 128.6 Actinobacteria nfeD ko:K07340 ko00000 Bacteria 2IHZU@201174,COG1585@1,COG1585@2 NA|NA|NA OU Membrane protein implicated in regulation of membrane protease activity KOPIJCMJ_00792 935839.JAGJ01000005_gene2600 1.4e-90 339.7 Promicromonosporaceae modF GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 3.6.3.21,3.6.3.34 ko:K02013,ko:K02028,ko:K05776 ko02010,map02010 M00189,M00236,M00240 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14,3.A.1.3 Bacteria 2GIXX@201174,4F3X4@85017,COG1119@1,COG1119@2 NA|NA|NA P ATPases associated with a variety of cellular activities KOPIJCMJ_00793 1304865.JAGF01000001_gene3501 3.3e-86 324.7 Cellulomonadaceae ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GKEH@201174,4F0VG@85016,COG1131@1,COG1131@2 NA|NA|NA V PFAM ABC transporter related KOPIJCMJ_00794 1304865.JAGF01000001_gene3500 4e-197 694.5 Actinobacteria ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GMSI@201174,COG3559@1,COG3559@2 NA|NA|NA M Exporter of polyketide KOPIJCMJ_00795 68194.JNXR01000009_gene5140 1.6e-12 80.1 Actinobacteria Bacteria 2DDE4@1,2I38G@201174,2ZHP5@2 NA|NA|NA KOPIJCMJ_00796 446469.Sked_30030 1.6e-49 202.6 Actinobacteria Bacteria 2GJJC@201174,COG0474@1,COG0474@2 NA|NA|NA P ATPase P-type (Transporting), HAD superfamily, subfamily IC KOPIJCMJ_00797 590998.Celf_1150 3.2e-127 461.8 Cellulomonadaceae galK 2.7.1.6,2.7.7.12 ko:K00849,ko:K00965 ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917 M00362,M00554,M00632 R00955,R01092 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GJXI@201174,4F1TD@85016,COG0153@1,COG0153@2 NA|NA|NA G Belongs to the GHMP kinase family. GalK subfamily KOPIJCMJ_00799 1304865.JAGF01000001_gene176 2.5e-39 168.3 Cellulomonadaceae ycdO GO:0000041,GO:0006810,GO:0006811,GO:0006812,GO:0006826,GO:0008150,GO:0015684,GO:0030001,GO:0051179,GO:0051234,GO:0070838,GO:0072511 ko:K07224 ko00000,ko02000 2.A.108.2.3 Bacteria 2GJPY@201174,4F1P3@85016,COG2822@1,COG2822@2 NA|NA|NA P Imelysin KOPIJCMJ_00800 593907.Celgi_2505 1.1e-155 556.6 Actinobacteria efeN ko:K16301 ko00000,ko01000,ko02000 2.A.108.2.3 Bacteria 2GIUB@201174,COG2837@1,COG2837@2 NA|NA|NA P peroxidase KOPIJCMJ_00801 446466.Cfla_1916 3.4e-111 407.9 Actinobacteria sdhB 1.3.5.1,1.3.5.4 ko:K00240,ko:K00245 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00149,M00150,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJPS@201174,COG0479@1,COG0479@2 NA|NA|NA C succinate dehydrogenase KOPIJCMJ_00802 446466.Cfla_1917 2.3e-52 211.5 Cellulomonadaceae sdhA 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ45@201174,4F0MT@85016,COG1053@1,COG1053@2 NA|NA|NA C PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein KOPIJCMJ_00803 1304865.JAGF01000001_gene2511 1.5e-69 269.6 Cellulomonadaceae 1.7.2.1 ko:K00368 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 Bacteria 2HG56@201174,4F1NM@85016,COG4243@1,COG4243@2 NA|NA|NA S Vitamin k epoxide reductase KOPIJCMJ_00804 1385518.N798_09205 2.1e-92 346.7 Intrasporangiaceae nirK 1.7.2.1 ko:K00368 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 Bacteria 2GPUP@201174,4FG4T@85021,COG2132@1,COG2132@2 NA|NA|NA Q Multicopper oxidase KOPIJCMJ_00807 420662.Mpe_A3085 7.7e-23 112.8 unclassified Burkholderiales dbi 1.1.1.35 ko:K07516 ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212 M00087 R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000 Bacteria 1KM9E@119065,1MZPP@1224,2VUK0@28216,COG4281@1,COG4281@2 NA|NA|NA I acyl-coA-binding protein KOPIJCMJ_00808 1121926.AXWO01000013_gene2101 9e-55 220.7 Glycomycetales ytnM ko:K07090 ko00000 Bacteria 2GNPE@201174,4EZI4@85014,COG0730@1,COG0730@2 NA|NA|NA S Sulfite exporter TauE/SafE KOPIJCMJ_00809 1869.MB27_19770 2.2e-87 328.9 Micromonosporales ppgK 2.7.1.2,2.7.1.63,5.3.1.9 ko:K00845,ko:K00886,ko:K01810 ko00010,ko00030,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114,M00549 R00299,R01600,R01786,R02187,R02189,R02739,R02740,R03321 RC00002,RC00017,RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GJA0@201174,4DCFF@85008,COG1940@1,COG1940@2 NA|NA|NA GK ROK family KOPIJCMJ_00810 1298863.AUEP01000005_gene2350 8.5e-21 106.7 Propionibacteriales Bacteria 2CEFP@1,2GT06@201174,2ZGIZ@2,4DVNV@85009 NA|NA|NA KOPIJCMJ_00811 1172188.KB911825_gene3704 2.3e-72 279.6 Intrasporangiaceae Bacteria 2IAG1@201174,4FEJ3@85021,COG4585@1,COG4585@2 NA|NA|NA T Histidine kinase KOPIJCMJ_00812 196162.Noca_2635 8.9e-57 226.9 Propionibacteriales Bacteria 2GJKM@201174,4DQZM@85009,COG2197@1,COG2197@2 NA|NA|NA T helix_turn_helix, Lux Regulon KOPIJCMJ_00813 1894.JOER01000006_gene836 1.5e-10 73.2 Actinobacteria 3.1.3.12 ko:K01087 ko00500,ko01100,map00500,map01100 R02778 RC00017 ko00000,ko00001,ko01000 Bacteria 2IKKW@201174,COG1877@1,COG1877@2 NA|NA|NA G trehalose-phosphatase activity KOPIJCMJ_00814 366602.Caul_2877 1.3e-64 253.4 Alphaproteobacteria yceM 1.1.1.18,1.1.1.369 ko:K00010,ko:K03810 ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130 R01183,R09951 RC00182 ko00000,ko00001,ko01000 Bacteria 1MVCX@1224,2UQ6G@28211,COG0673@1,COG0673@2 NA|NA|NA S Oxidoreductase family, NAD-binding Rossmann fold KOPIJCMJ_00815 1206725.BAFU01000044_gene2179 2.7e-56 226.5 Nocardiaceae 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 2HEI2@201174,4FV0Z@85025,COG2199@1,COG2199@2,COG5000@1,COG5000@2 NA|NA|NA T diguanylate cyclase KOPIJCMJ_00816 66377.JOBH01000008_gene6677 1.7e-38 166.0 Actinobacteria pfs 3.2.2.1,3.2.2.9 ko:K01239,ko:K01243 ko00230,ko00270,ko00760,ko01100,ko01230,map00230,map00270,map00760,map01100,map01230 M00034,M00609 R00194,R01245,R01273,R01401,R01677,R01770,R02143 RC00033,RC00063,RC00122,RC00318,RC00485 ko00000,ko00001,ko00002,ko01000 Bacteria 2IMZ7@201174,COG0775@1,COG0775@2 NA|NA|NA F nucleosidase KOPIJCMJ_00817 394.NGR_c28520 2.3e-184 651.7 Rhizobiaceae arcA 3.5.3.6 ko:K01478 ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130 R00552 RC00177 ko00000,ko00001,ko01000 Bacteria 1NCGV@1224,2TU0Z@28211,4BAQ4@82115,COG2235@1,COG2235@2 NA|NA|NA E Arginine KOPIJCMJ_00818 762948.HMPREF0733_10179 1.1e-13 82.4 Micrococcaceae Bacteria 1WAB6@1268,2IQY7@201174,COG2261@1,COG2261@2 NA|NA|NA S Transglycosylase associated protein KOPIJCMJ_00820 1150864.MILUP08_45615 7.1e-48 197.6 Micromonosporales 4.2.1.18 ko:K13766 ko00280,ko01100,map00280,map01100 M00036 R02085 RC02416 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ0N@201174,4D9QW@85008,COG1024@1,COG1024@2 NA|NA|NA I enoyl-CoA hydratase KOPIJCMJ_00821 2002.JOEQ01000005_gene3278 4.3e-30 138.3 Streptosporangiales Bacteria 2GP59@201174,4EQ00@85012,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family KOPIJCMJ_00823 1238182.C882_4443 8.7e-82 311.2 Rhodospirillales ko:K06990,ko:K09141 ko00000,ko04812 Bacteria 1MXK5@1224,2JQVM@204441,2U13I@28211,COG1355@1,COG1355@2,COG2078@1,COG2078@2 NA|NA|NA S Belongs to the MEMO1 family KOPIJCMJ_00824 1244869.H261_09237 6.4e-94 350.5 Rhodospirillales pflA 1.97.1.4 ko:K04069 R04710 ko00000,ko01000 Bacteria 1NQC1@1224,2JR7Y@204441,2TU6P@28211,COG1180@1,COG1180@2 NA|NA|NA C Radical SAM superfamily KOPIJCMJ_00825 1907.SGLAU_22145 6.4e-99 367.5 Actinobacteria deaD 3.6.4.13 ko:K05592,ko:K11927 ko03018,map03018 ko00000,ko00001,ko01000,ko03009,ko03019 Bacteria 2GIUR@201174,COG0513@1,COG0513@2 NA|NA|NA L Belongs to the DEAD box helicase family KOPIJCMJ_00826 1048339.KB913029_gene2907 3.7e-13 80.9 Frankiales Bacteria 2C4RB@1,2HAZK@201174,2ZVRN@2,4EWZ7@85013 NA|NA|NA KOPIJCMJ_00827 1048339.KB913029_gene2906 4.1e-99 367.9 Frankiales soj ko:K03496 ko00000,ko03036,ko04812 Bacteria 2GNEQ@201174,4EUFG@85013,COG1192@1,COG1192@2 NA|NA|NA D Cellulose biosynthesis protein BcsQ KOPIJCMJ_00828 1449346.JQMO01000003_gene3193 4.6e-43 181.8 Kitasatospora Bacteria 2GKPK@201174,2M0AS@2063,COG2267@1,COG2267@2 NA|NA|NA I Serine aminopeptidase, S33 KOPIJCMJ_00829 1906.SFRA_14425 2.5e-18 98.6 Actinobacteria prpE2 Bacteria 2GK8P@201174,COG0642@1,COG0642@2,COG2208@1,COG2208@2 NA|NA|NA T protein phosphatase 2C domain protein KOPIJCMJ_00830 397278.JOJN01000006_gene1006 2.9e-50 206.1 Propionibacteriales 3.1.1.29 ko:K01056 ko00000,ko01000,ko03012 Bacteria 2HVQW@201174,4DQVN@85009,COG4427@1,COG4427@2 NA|NA|NA S Uncharacterized protein conserved in bacteria (DUF2332) KOPIJCMJ_00831 1184609.KILIM_030_00380 1.3e-20 104.8 Dermatophilaceae Bacteria 2GIX8@201174,4F65M@85018,COG1960@1,COG1960@2 NA|NA|NA I Acyl-CoA dehydrogenase, C-terminal domain KOPIJCMJ_00832 1121271.AUCM01000023_gene3035 4.7e-89 334.7 Alphaproteobacteria Bacteria 1QU07@1224,2TR07@28211,COG3087@1,COG3087@2 NA|NA|NA D peptidase U35 phage prohead HK97 KOPIJCMJ_00833 66377.JOBH01000015_gene4135 3.8e-110 404.8 Actinobacteria yumC GO:0008150,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0042221,GO:0050896,GO:0051716,GO:0070887,GO:0071241,GO:0071248,GO:0071281 1.18.1.2,1.19.1.1 ko:K21567 ko00000,ko01000 iYO844.BSU32110 Bacteria 2GJ1Z@201174,COG0492@1,COG0492@2 NA|NA|NA C Ferredoxin-NADP reductase KOPIJCMJ_00834 561175.KB894100_gene4794 9.3e-44 184.1 Streptosporangiales ko:K07058 ko00000 Bacteria 2GM6P@201174,4EIBQ@85012,COG1295@1,COG1295@2 NA|NA|NA S Virulence factor BrkB KOPIJCMJ_00835 1033730.CAHG01000012_gene2363 3.7e-11 73.2 Propionibacteriales Bacteria 2EGJK@1,2GX71@201174,33ABR@2,4DSKZ@85009 NA|NA|NA KOPIJCMJ_00837 1077972.ARGLB_050_00040 5e-132 478.4 Micrococcaceae ko:K06883 ko00000 Bacteria 1W8MB@1268,2GJX9@201174,COG0699@1,COG0699@2 NA|NA|NA S Dynamin family KOPIJCMJ_00838 471853.Bcav_2640 7.9e-89 334.7 Actinobacteria PPA1638 ko:K06883 ko00000 Bacteria 2GM68@201174,COG0699@1,COG0699@2 NA|NA|NA K ABC transporter KOPIJCMJ_00839 1536773.R70331_22715 2.3e-65 256.1 Paenibacillaceae 1.6.5.5 ko:K00344 ko00000,ko01000 Bacteria 1TZGF@1239,26UA2@186822,4HEDQ@91061,COG0604@1,COG0604@2 NA|NA|NA C Zinc-binding alcohol dehydrogenase KOPIJCMJ_00840 512565.AMIS_37850 1.4e-40 172.6 Micromonosporales hsp20 ko:K13993 ko04141,map04141 ko00000,ko00001,ko03110 Bacteria 2IHVJ@201174,4DE8J@85008,COG0071@1,COG0071@2 NA|NA|NA O Belongs to the small heat shock protein (HSP20) family KOPIJCMJ_00842 935839.JAGJ01000016_gene2363 2e-38 165.6 Promicromonosporaceae Bacteria 2IM6D@201174,4F4NF@85017,COG4119@1,COG4119@2 NA|NA|NA L NUDIX domain KOPIJCMJ_00843 1463825.JNXC01000017_gene6952 1.5e-220 772.7 Pseudonocardiales Bacteria 2GIUI@201174,4DXAD@85010,COG3408@1,COG3408@2 NA|NA|NA G Glycogen debranching enzyme KOPIJCMJ_00844 1463825.JNXC01000017_gene6951 1.3e-92 346.7 Pseudonocardiales ko:K00713,ko:K06338 ko00000,ko01000,ko01003,ko01005 Bacteria 2I005@201174,4DXXN@85010,COG0438@1,COG0438@2 NA|NA|NA M PFAM Glycosyl transferases group 1 KOPIJCMJ_00845 590998.Celf_3039 1.3e-220 773.5 Actinobacteria Bacteria 2GN7G@201174,COG3291@1,COG3291@2 NA|NA|NA P PFAM PKD domain containing protein KOPIJCMJ_00847 1120942.AUBM01000007_gene585 1.2e-145 523.1 Actinobacteria nplT Bacteria 2GJUT@201174,4D48F@85005,COG0366@1,COG0366@2 NA|NA|NA G Alpha amylase, catalytic domain protein KOPIJCMJ_00848 77635.BISU_0868 3.2e-51 208.4 Bacteria Bacteria COG1309@1,COG1309@2 NA|NA|NA K transcriptional regulator KOPIJCMJ_00849 44251.PDUR_02765 6.7e-37 161.0 Paenibacillaceae ko:K05772 ko02010,map02010 M00186 ko00000,ko00001,ko00002,ko02000 3.A.1.6.2,3.A.1.6.4 Bacteria 1UI3M@1239,27712@186822,4ISC5@91061,COG2998@1,COG2998@2 NA|NA|NA H Copper amine oxidase N-terminal domain KOPIJCMJ_00850 1100721.ALKO01000016_gene1456 1.8e-86 326.2 Comamonadaceae Bacteria 1MWDP@1224,2VHM1@28216,4ABW8@80864,COG3191@1,COG3191@2 NA|NA|NA EQ PFAM peptidase S58 DmpA KOPIJCMJ_00851 1380390.JIAT01000010_gene3784 3.5e-27 128.6 Actinobacteria 1.3.1.33 ko:K00218 ko00860,ko01100,ko01110,map00860,map01100,map01110 R03845,R06286 RC01008 ko00000,ko00001,ko01000 Bacteria 2I3A4@201174,COG4221@1,COG4221@2 NA|NA|NA S short chain dehydrogenase KOPIJCMJ_00852 1172188.KB911822_gene998 6e-58 231.1 Intrasporangiaceae ko:K06996 ko00000 Bacteria 2GJFC@201174,4FGZF@85021,COG3324@1,COG3324@2 NA|NA|NA S glyoxalase bleomycin resistance protein dioxygenase KOPIJCMJ_00853 1121004.ATVC01000005_gene1381 3.6e-74 286.6 Betaproteobacteria Bacteria 1MU2C@1224,2VH3V@28216,COG5001@1,COG5001@2 NA|NA|NA T Diguanylate cyclase KOPIJCMJ_00854 1386089.N865_06805 1e-166 593.2 Intrasporangiaceae ndh 1.6.99.3 ko:K03885 ko00190,map00190 ko00000,ko00001,ko01000 Bacteria 2GJFE@201174,4FENQ@85021,COG1252@1,COG1252@2 NA|NA|NA C NADH dehydrogenase KOPIJCMJ_00858 1306174.JODP01000009_gene6554 2e-59 236.1 Actinobacteria ko:K12510 ko00000,ko02044 Bacteria 2H577@201174,COG4965@1,COG4965@2 NA|NA|NA U Type ii secretion system KOPIJCMJ_00859 1122609.AUGT01000012_gene4249 6.4e-67 261.2 Propionibacteriales ko:K12511 ko00000,ko02044 Bacteria 2GK7B@201174,4DR34@85009,COG2064@1,COG2064@2 NA|NA|NA NU Type II secretion system KOPIJCMJ_00862 367299.JOEE01000003_gene2964 7.9e-32 145.2 Intrasporangiaceae Bacteria 2ICX6@201174,4FF5W@85021,COG1287@1,COG1287@2 NA|NA|NA S oligosaccharyl transferase activity KOPIJCMJ_00863 471852.Tcur_2117 5.3e-34 152.1 Streptosporangiales Bacteria 2GN1J@201174,4EJA0@85012,COG5650@1,COG5650@2 NA|NA|NA S Glycosyltransferase family 87 KOPIJCMJ_00864 2074.JNYD01000016_gene4254 3.9e-21 109.4 Pseudonocardiales ko:K13671 ko00000,ko01000,ko01003 GT87 Bacteria 2GJBC@201174,4E0FQ@85010,COG5650@1,COG5650@2 NA|NA|NA S Glycosyltransferase family 87 KOPIJCMJ_00865 211114.JOEF01000026_gene262 1.1e-20 107.8 Pseudonocardiales ko:K13671 ko00000,ko01000,ko01003 GT87 Bacteria 2GJBC@201174,4DZJI@85010,COG5650@1,COG5650@2 NA|NA|NA S Glycosyltransferase family 87 KOPIJCMJ_00866 479432.Sros_8386 1.1e-65 256.9 Streptosporangiales Bacteria 2GM96@201174,4EI1R@85012,COG2267@1,COG2267@2 NA|NA|NA I Serine aminopeptidase, S33 KOPIJCMJ_00868 1122138.AQUZ01000005_gene2733 4.5e-52 211.1 Propionibacteriales Bacteria 2GMEH@201174,4DNZG@85009,COG1028@1,COG1028@2 NA|NA|NA IQ Enoyl-(Acyl carrier protein) reductase KOPIJCMJ_00869 1122138.AQUZ01000001_gene1538 3.2e-222 778.1 Propionibacteriales msbA9 ko:K06147 ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 2GITR@201174,4DN7W@85009,COG1132@1,COG1132@2 NA|NA|NA V ABC transporter transmembrane region KOPIJCMJ_00870 566461.SSFG_05534 1.7e-65 256.1 Actinobacteria echA Bacteria 2GKC4@201174,COG1024@1,COG1024@2 NA|NA|NA I Belongs to the enoyl-CoA hydratase isomerase family KOPIJCMJ_00871 1463845.JOIG01000007_gene549 9e-12 75.9 Actinobacteria Bacteria 2E4I7@1,2IQBB@201174,32ZDA@2 NA|NA|NA S transcriptional regulator KOPIJCMJ_00872 479432.Sros_5972 1.3e-208 732.6 Streptosporangiales ybiT Bacteria 2GKQ4@201174,4EG0G@85012,COG0488@1,COG0488@2 NA|NA|NA S ABC transporter KOPIJCMJ_00873 1048339.KB913029_gene3748 1e-77 297.0 Frankiales ypfJ GO:0005575,GO:0005576 ko:K07054 ko00000 Bacteria 2H3UT@201174,4ES25@85013,COG2321@1,COG2321@2 NA|NA|NA S Putative neutral zinc metallopeptidase KOPIJCMJ_00874 1121272.KB903261_gene6476 7.4e-98 363.6 Micromonosporales coaX GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1986 Bacteria 2GMRQ@201174,4D9W0@85008,COG1521@1,COG1521@2 NA|NA|NA H Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis KOPIJCMJ_00875 1463845.JOIG01000008_gene3720 2.7e-99 368.6 Actinobacteria nadC 1.4.3.16,2.4.2.19 ko:K00278,ko:K00767 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481,R03348 RC00006,RC02566,RC02877 ko00000,ko00001,ko00002,ko01000 Bacteria 2I2IP@201174,COG0157@1,COG0157@2 NA|NA|NA H Belongs to the NadC ModD family KOPIJCMJ_00876 1996.JOFO01000058_gene692 6.5e-10 69.7 Streptosporangiales nadB 1.3.5.4,1.4.3.16,2.4.2.19 ko:K00244,ko:K00278,ko:K00767 ko00020,ko00190,ko00250,ko00620,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00250,map00620,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00115,M00150,M00173 R00357,R00481,R02164,R03348 RC00006,RC00045,RC02566,RC02877 ko00000,ko00001,ko00002,ko01000 Bacteria 2I2IJ@201174,4EFXC@85012,COG0029@1,COG0029@2 NA|NA|NA H Catalyzes the oxidation of L-aspartate to iminoaspartate KOPIJCMJ_00877 196162.Noca_2013 2.5e-66 258.8 Propionibacteriales yqfO GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.5.4.16 ko:K11022,ko:K22391 ko00790,ko01100,ko05134,map00790,map01100,map05134 M00126 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000,ko02042 Bacteria 2GKHZ@201174,4DN28@85009,COG0327@1,COG0327@2,COG3323@1,COG3323@2 NA|NA|NA S Belongs to the GTP cyclohydrolase I type 2 NIF3 family KOPIJCMJ_00878 58123.JOFJ01000005_gene1472 2.9e-54 218.8 Streptosporangiales ko:K07164 ko00000 Bacteria 2GP84@201174,4EH3Z@85012,COG1579@1,COG1579@2 NA|NA|NA S C4-type zinc ribbon domain KOPIJCMJ_00879 66377.JOBH01000001_gene1096 8.9e-96 357.5 Actinobacteria rnhA GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006401,GO:0006725,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016891,GO:0016893,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0032296,GO:0033013,GO:0033014,GO:0034641,GO:0034655,GO:0042364,GO:0042578,GO:0043170,GO:0043755,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046700,GO:0051186,GO:0051188,GO:0071667,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576 3.1.26.4,3.1.3.3,3.1.3.73,3.1.3.85,5.4.2.12 ko:K02226,ko:K03469,ko:K06864,ko:K15634,ko:K22305,ko:K22306,ko:K22316 ko00010,ko00260,ko00680,ko00860,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03030,map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01130,map01200,map01230,map03030 M00001,M00002,M00003,M00122 R00582,R01518,R04594,R11173 RC00017,RC00536 ko00000,ko00001,ko00002,ko01000,ko03032 Bacteria 2GJ9R@201174,COG0328@1,COG0328@2,COG0406@1,COG0406@2 NA|NA|NA GL phosphoglycerate mutase KOPIJCMJ_00880 469383.Cwoe_0617 8.4e-117 426.8 Actinobacteria 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 Bacteria 2I8G2@201174,COG0685@1,COG0685@2 NA|NA|NA E methylenetetrahydrofolate reductase (NAD(P)H) activity KOPIJCMJ_00882 1043205.AFYF01000048_gene2986 3.3e-98 364.8 Intrasporangiaceae Bacteria 2GN74@201174,4FFY8@85021,COG1357@1,COG1357@2 NA|NA|NA S DinB superfamily KOPIJCMJ_00883 196162.Noca_2810 2.2e-84 318.5 Propionibacteriales MA20_05015 Bacteria 2IHPD@201174,4DWVV@85009,COG0500@1,COG2226@2 NA|NA|NA Q Methyltransferase domain KOPIJCMJ_00884 40571.JOEA01000013_gene1275 4.4e-10 69.3 Pseudonocardiales Bacteria 2E5NA@1,2IQ91@201174,330D3@2,4E5UJ@85010 NA|NA|NA S Domain of unknown function (DUF4287) KOPIJCMJ_00886 935839.JAGJ01000001_gene964 5e-260 903.7 Promicromonosporaceae pckG GO:0000003,GO:0001655,GO:0001822,GO:0001889,GO:0003006,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004457,GO:0004611,GO:0004613,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006066,GO:0006071,GO:0006082,GO:0006089,GO:0006090,GO:0006091,GO:0006094,GO:0006109,GO:0006111,GO:0006113,GO:0006139,GO:0006163,GO:0006464,GO:0006629,GO:0006631,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007028,GO:0007154,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007296,GO:0007610,GO:0008150,GO:0008152,GO:0008906,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009166,GO:0009167,GO:0009179,GO:0009185,GO:0009199,GO:0009205,GO:0009259,GO:0009267,GO:0009410,GO:0009605,GO:0009607,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009889,GO:0009966,GO:0009967,GO:0009987,GO:0009991,GO:0010033,GO:0010106,GO:0010243,GO:0010646,GO:0010647,GO:0010675,GO:0010906,GO:0014070,GO:0014074,GO:0015036,GO:0015980,GO:0016020,GO:0016042,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016054,GO:0016301,GO:0016310,GO:0016491,GO:0016614,GO:0016651,GO:0016667,GO:0016668,GO:0016740,GO:0016772,GO:0016773,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017001,GO:0017144,GO:0018130,GO:0018991,GO:0019098,GO:0019222,GO:0019249,GO:0019318,GO:0019319,GO:0019320,GO:0019362,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019516,GO:0019538,GO:0019541,GO:0019543,GO:0019563,GO:0019626,GO:0019637,GO:0019659,GO:0019660,GO:0019661,GO:0019666,GO:0019674,GO:0019693,GO:0019725,GO:0019751,GO:0019752,GO:0019953,GO:0022412,GO:0022414,GO:0023051,GO:0023056,GO:0030003,GO:0030145,GO:0030154,GO:0030312,GO:0030703,GO:0030855,GO:0031323,GO:0031667,GO:0031668,GO:0031669,GO:0031960,GO:0031974,GO:0032501,GO:0032502,GO:0032504,GO:0032787,GO:0032868,GO:0032869,GO:0032870,GO:0033554,GO:0033993,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035690,GO:0036211,GO:0042221,GO:0042493,GO:0042592,GO:0042594,GO:0042737,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043255,GO:0043412,GO:0043434,GO:0043436,GO:0043687,GO:0043900,GO:0043903,GO:0043949,GO:0043950,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044267,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045471,GO:0046031,GO:0046034,GO:0046164,GO:0046174,GO:0046364,GO:0046365,GO:0046394,GO:0046395,GO:0046434,GO:0046459,GO:0046483,GO:0046496,GO:0046677,GO:0046683,GO:0046700,GO:0046872,GO:0046914,GO:0046916,GO:0047134,GO:0048468,GO:0048477,GO:0048513,GO:0048518,GO:0048522,GO:0048545,GO:0048562,GO:0048568,GO:0048583,GO:0048584,GO:0048598,GO:0048609,GO:0048646,GO:0048731,GO:0048732,GO:0048856,GO:0048869,GO:0048878,GO:0050789,GO:0050792,GO:0050794,GO:0050801,GO:0050896,GO:0051186,GO:0051384,GO:0051591,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055086,GO:0055114,GO:0060429,GO:0061005,GO:0061008,GO:0062012,GO:0065007,GO:0065008,GO:0070013,GO:0070365,GO:0070887,GO:0071236,GO:0071310,GO:0071361,GO:0071375,GO:0071383,GO:0071384,GO:0071385,GO:0071396,GO:0071407,GO:0071417,GO:0071466,GO:0071495,GO:0071496,GO:0071548,GO:0071549,GO:0071704,GO:0071840,GO:0071944,GO:0072001,GO:0072071,GO:0072329,GO:0072330,GO:0072521,GO:0072524,GO:0075136,GO:0080090,GO:0097159,GO:0097237,GO:0097305,GO:0097306,GO:0097327,GO:0098771,GO:1901135,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901575,GO:1901576,GO:1901615,GO:1901616,GO:1901617,GO:1901652,GO:1901653,GO:1901654,GO:1901655,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902533 4.1.1.32,4.1.1.49 ko:K01596,ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964 M00003,M00170 R00341,R00431,R00726 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2638 Bacteria 2GJH3@201174,4F3XG@85017,COG1274@1,COG1274@2 NA|NA|NA H Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle KOPIJCMJ_00887 479435.Kfla_0588 4.1e-97 361.7 Propionibacteriales holB GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 2GJ8C@201174,4DNVR@85009,COG0470@1,COG0470@2 NA|NA|NA L DNA polymerase III KOPIJCMJ_00889 266940.Krad_0491 5.4e-127 461.5 Actinobacteria slpD Bacteria 2GJYS@201174,COG0596@1,COG0596@2 NA|NA|NA NU Alpha beta hydrolase KOPIJCMJ_00890 1380393.JHVP01000002_gene1670 1.5e-115 422.5 Frankiales rfbA GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0005996,GO:0006006,GO:0006139,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008879,GO:0009058,GO:0009059,GO:0009117,GO:0009141,GO:0009147,GO:0009200,GO:0009211,GO:0009219,GO:0009225,GO:0009226,GO:0009262,GO:0009394,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019299,GO:0019300,GO:0019305,GO:0019318,GO:0019319,GO:0019438,GO:0019637,GO:0019692,GO:0030312,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0045226,GO:0046075,GO:0046364,GO:0046379,GO:0046383,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv0334 Bacteria 2GP20@201174,4ETV6@85013,COG1209@1,COG1209@2 NA|NA|NA M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis KOPIJCMJ_00891 43354.JOIJ01000013_gene689 1.3e-142 512.7 Pseudonocardiales rfbB 4.2.1.46,4.2.1.76 ko:K01710,ko:K12450 ko00520,ko00521,ko00523,ko00525,ko01055,ko01130,map00520,map00521,map00523,map00525,map01055,map01130 M00793 R00293,R06513 RC00402 ko00000,ko00001,ko00002,ko01000 Bacteria 2GNDU@201174,4E023@85010,COG1088@1,COG1088@2 NA|NA|NA M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily KOPIJCMJ_00892 1463858.JOHR01000009_gene3366 2.5e-97 362.1 Actinobacteria rmlD GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008831,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019305,GO:0019438,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 Bacteria 2GNY8@201174,COG1091@1,COG1091@2 NA|NA|NA M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose KOPIJCMJ_00893 1121272.KB903283_gene5123 2.3e-36 158.3 Actinobacteria Bacteria 2IIQY@201174,COG1917@1,COG1917@2 NA|NA|NA S Cupin 2, conserved barrel domain protein KOPIJCMJ_00894 446471.Xcel_2560 8.2e-76 290.0 Promicromonosporaceae rmlC GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008830,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016853,GO:0016854,GO:0016857,GO:0018130,GO:0019305,GO:0019438,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576 5.1.3.13 ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R06514 RC01531 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv3465 Bacteria 2GMW4@201174,4F3ZC@85017,COG1898@1,COG1898@2 NA|NA|NA M dTDP-4-dehydrorhamnose 3,5-epimerase KOPIJCMJ_00897 1114959.SZMC14600_05067 3e-34 151.0 Pseudonocardiales whiB3 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0008152,GO:0009273,GO:0009405,GO:0009987,GO:0010565,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0019216,GO:0019217,GO:0019222,GO:0019725,GO:0030312,GO:0031323,GO:0042546,GO:0042592,GO:0043254,GO:0044085,GO:0044087,GO:0044419,GO:0044464,GO:0045454,GO:0048037,GO:0048583,GO:0050789,GO:0050794,GO:0051128,GO:0051536,GO:0051539,GO:0051540,GO:0051704,GO:0055114,GO:0062012,GO:0065007,GO:0065008,GO:0071554,GO:0071766,GO:0071840,GO:0071944,GO:0080090,GO:0080134,GO:0090034,GO:0097159,GO:1901363,GO:1902882 ko:K18955 ko00000,ko03000 Bacteria 2CC1Y@1,2IQS5@201174,32S23@2,4E4SU@85010 NA|NA|NA K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA KOPIJCMJ_00898 1122622.ATWJ01000007_gene1560 5.1e-221 773.9 Intrasporangiaceae groL GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006457,GO:0006458,GO:0006725,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009295,GO:0009408,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016465,GO:0030312,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042026,GO:0042262,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043388,GO:0043590,GO:0044093,GO:0044183,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0050896,GO:0051082,GO:0051098,GO:0051099,GO:0051101,GO:0051716,GO:0061077,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090143,GO:0090304,GO:0097159,GO:0101031,GO:1901360,GO:1901363,GO:1990220,GO:2000677,GO:2000679 ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 Bacteria 2GKC9@201174,4FF25@85021,COG0459@1,COG0459@2 NA|NA|NA O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions KOPIJCMJ_00899 1306174.JODP01000006_gene3620 6.1e-40 169.9 Actinobacteria groS GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 ko:K04078 ko00000,ko03029,ko03110 Bacteria 2IKTH@201174,COG0234@1,COG0234@2 NA|NA|NA O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter KOPIJCMJ_00900 1157640.AQWO01000012_gene167 1.1e-67 264.2 Actinobacteria Bacteria 2GK97@201174,COG2265@1,COG2265@2 NA|NA|NA J COG0500 SAM-dependent methyltransferases KOPIJCMJ_00902 1306174.JODP01000003_gene1895 7e-36 157.5 Actinobacteria Bacteria 2I8Y7@201174,COG2197@1,COG2197@2 NA|NA|NA KT Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain KOPIJCMJ_00903 1169161.KB897730_gene1069 3.1e-12 80.9 Actinobacteria Bacteria 2I8JH@201174,COG4585@1,COG4585@2 NA|NA|NA T signal transduction histidine kinase KOPIJCMJ_00904 1184609.KILIM_003_00270 3.2e-152 544.7 Dermatophilaceae tsaD GO:0000287,GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140030,GO:0140032,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 ko:K01409,ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 R10648 RC00070,RC00416 ko00000,ko00001,ko00002,ko01000,ko02044,ko03016 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 Bacteria 2GJ98@201174,4F606@85018,COG0533@1,COG0533@2 NA|NA|NA J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction KOPIJCMJ_00905 235985.BBPN01000023_gene2700 4.5e-27 127.9 Streptacidiphilus rimI GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008999,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0017189,GO:0018193,GO:0018194,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564 2.3.1.128,2.3.1.234 ko:K01409,ko:K03789,ko:K14742 R10648 RC00070,RC00416 ko00000,ko01000,ko03009,ko03016 Bacteria 2IM9R@201174,2NH04@228398,COG0454@1,COG0456@2 NA|NA|NA K Acetyltransferase (GNAT) domain KOPIJCMJ_00906 1449353.JQMQ01000005_gene3688 9.7e-46 190.3 Streptacidiphilus yeaZ GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0071944,GO:0090304,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 ko:K01409,ko:K14742 R10648 RC00070,RC00416 ko00000,ko01000,ko03016 Bacteria 2GMTM@201174,2NF90@228398,COG1214@1,COG1214@2 NA|NA|NA O Glycoprotease family KOPIJCMJ_00907 935839.JAGJ01000006_gene3358 5.9e-44 184.1 Promicromonosporaceae ydiB GO:0002949,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.7.1.221,5.1.1.1 ko:K01775,ko:K06925,ko:K07102 ko00473,ko00520,ko01100,ko01502,map00473,map00520,map01100,map01502 R00401,R08968,R11024 RC00002,RC00078,RC00285 ko00000,ko00001,ko01000,ko01011,ko03016 Bacteria 2IKV2@201174,4F4GX@85017,COG0802@1,COG0802@2 NA|NA|NA S Threonylcarbamoyl adenosine biosynthesis protein TsaE KOPIJCMJ_00908 479432.Sros_1142 5.3e-82 311.6 Streptosporangiales Bacteria 2GMCK@201174,4EFMQ@85012,COG2267@1,COG2267@2 NA|NA|NA I Serine aminopeptidase, S33 KOPIJCMJ_00909 1380346.JNIH01000003_gene2082 1.9e-118 432.6 Actinobacteria alr GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008784,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0019842,GO:0030170,GO:0030203,GO:0034645,GO:0036094,GO:0036361,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0047661,GO:0048037,GO:0050662,GO:0070279,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 R00401 RC00285 ko00000,ko00001,ko01000,ko01011 iEC55989_1330.EC55989_1285,iECIAI39_1322.ECIAI39_1880,iECO103_1326.ECO103_1292,iECO26_1355.ECO26_1703,iECSE_1348.ECSE_1238,iECUMN_1333.ECUMN_1479,iECW_1372.ECW_m1275,iEKO11_1354.EKO11_2666,iEcE24377_1341.EcE24377A_1335,iPC815.YPO0321,iSBO_1134.SBO_4064,iSbBS512_1146.SbBS512_E4542,iWFL_1372.ECW_m1275,iYL1228.KPN_02308,iYL1228.KPN_04440 Bacteria 2GM2Y@201174,COG0787@1,COG0787@2 NA|NA|NA E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids KOPIJCMJ_00910 1048339.KB913029_gene2786 7.1e-76 291.6 Frankiales nnrD GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0052855,GO:0052856,GO:0052857 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 ko00000,ko01000 Bacteria 2GJHB@201174,4ERGP@85013,COG0062@1,COG0062@2,COG0063@1,COG0063@2 NA|NA|NA G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration KOPIJCMJ_00911 1156844.KB891797_gene5833 9.4e-264 916.0 Actinobacteria glmS GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016020,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 iNJ661.Rv3436c,iSB619.SA_RS11245,iYO844.BSU01780 Bacteria 2GKH0@201174,COG0449@1,COG0449@2 NA|NA|NA M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source KOPIJCMJ_00912 1120950.KB892784_gene183 3.2e-168 598.2 Propionibacteriales glmM GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006464,GO:0006468,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008966,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019538,GO:0034641,GO:0034654,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046777,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 R02060 RC00408 ko00000,ko00001,ko01000 iAF987.Gmet_1886,iLJ478.TM0184,iSB619.SA_RS11275,iSBO_1134.SBO_3206 Bacteria 2GN87@201174,4DNFP@85009,COG1109@1,COG1109@2 NA|NA|NA G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate KOPIJCMJ_00913 471853.Bcav_3105 3.5e-56 224.6 Actinobacteria rpsI GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02996 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GNDY@201174,COG0103@1,COG0103@2 NA|NA|NA J Belongs to the universal ribosomal protein uS9 family KOPIJCMJ_00914 1123321.KB905817_gene5166 1e-61 243.0 Actinobacteria rplM GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0070180,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 ko:K02871 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IFG1@201174,COG0102@1,COG0102@2 NA|NA|NA J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly KOPIJCMJ_00915 269800.Tfu_0522 6.3e-25 120.2 Streptosporangiales ybaZ GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0005488,GO:0005515,GO:0019899,GO:0097159,GO:1901363 2.1.1.63 ko:K00567,ko:K07443 ko00000,ko01000,ko03400 Bacteria 2GQMD@201174,4EKN0@85012,COG3695@1,COG3695@2 NA|NA|NA L 6-O-methylguanine DNA methyltransferase, DNA binding domain KOPIJCMJ_00916 1122138.AQUZ01000015_gene6722 1.1e-196 693.0 Propionibacteriales Bacteria 2GMUD@201174,4DNQ6@85009,COG0488@1,COG0488@2 NA|NA|NA S ABC transporter KOPIJCMJ_00917 1120946.AUBF01000012_gene1136 5.8e-144 517.3 Actinobacteria ko:K10546 ko02010,map02010 M00216 ko00000,ko00001,ko00002,ko02000 3.A.1.2.5 Bacteria 2GKRE@201174,4D5CU@85005,COG4213@1,COG4213@2 NA|NA|NA G Periplasmic binding protein domain KOPIJCMJ_00918 446466.Cfla_3403 7.1e-173 613.6 Cellulomonadaceae gguB GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0016020,GO:0016021,GO:0019321,GO:0031224,GO:0042732,GO:0044238,GO:0044281,GO:0044425,GO:0044464,GO:0071704,GO:0071944 ko:K10547 ko02010,map02010 M00216 ko00000,ko00001,ko00002,ko02000 3.A.1.2.5 Bacteria 2GJAH@201174,4F0VZ@85016,COG4214@1,COG4214@2 NA|NA|NA G Belongs to the binding-protein-dependent transport system permease family KOPIJCMJ_00919 218140.BPSY_1116 3.9e-33 147.1 Bifidobacteriales gguA 3.6.3.17 ko:K10545,ko:K10548 ko02010,map02010 M00215,M00216 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2.4,3.A.1.2.5 Bacteria 2GJ3F@201174,4CZ8Y@85004,COG1129@1,COG1129@2 NA|NA|NA G ATPases associated with a variety of cellular activities KOPIJCMJ_00920 1385520.N802_06105 1.3e-61 243.0 Actinobacteria Bacteria 2IFYE@201174,COG2197@1,COG2197@2 NA|NA|NA K helix_turn_helix, Lux Regulon KOPIJCMJ_00921 1385520.N802_06110 1e-150 540.8 Actinobacteria degS Bacteria 2HDZV@201174,COG4585@1,COG4585@2 NA|NA|NA T Histidine kinase KOPIJCMJ_00922 1385520.N802_06100 1.1e-33 149.8 Actinobacteria Bacteria 2E76N@1,2GRXJ@201174,338EF@2 NA|NA|NA KOPIJCMJ_00923 1385520.N802_06095 1.5e-156 559.7 Actinobacteria Bacteria 2GMJ4@201174,COG2132@1,COG2132@2 NA|NA|NA Q Multicopper oxidase KOPIJCMJ_00924 1027371.GOALK_026_00440 1.5e-57 229.6 Gordoniaceae Bacteria 2I51D@201174,4GF97@85026,COG3945@1,COG3945@2 NA|NA|NA S Hemerythrin HHE cation binding domain KOPIJCMJ_00929 585529.HMPREF0291_11787 1.4e-24 119.8 Actinobacteria Bacteria 2DN7X@1,2IQJG@201174,32W0S@2 NA|NA|NA KOPIJCMJ_00930 710696.Intca_3511 2e-73 282.3 Intrasporangiaceae 3.6.1.55 ko:K03574 ko00000,ko01000,ko03400 Bacteria 2IJP8@201174,4FF1N@85021,COG4923@1,COG4923@2 NA|NA|NA K Protein of unknown function (DUF429) KOPIJCMJ_00931 1122237.AUGQ01000001_gene854 8.7e-20 102.8 Microbacteriaceae ko:K07497 ko00000 Bacteria 2GNRT@201174,4FK6C@85023,COG2801@1,COG2801@2 NA|NA|NA L Integrase core domain KOPIJCMJ_00932 1429046.RR21198_2523 1.1e-34 153.3 Bacteria Bacteria 3342X@2,arCOG13037@1 NA|NA|NA KOPIJCMJ_00933 765910.MARPU_15230 5.4e-16 92.8 Chromatiales Bacteria 1RD0Y@1224,1S5AD@1236,1WY9F@135613,28PC1@1,2ZC4I@2 NA|NA|NA KOPIJCMJ_00934 367299.JOEE01000004_gene1261 2.4e-32 144.8 Intrasporangiaceae ko:K10947 ko00000,ko03000 Bacteria 2IQ51@201174,4FJ5V@85021,COG1695@1,COG1695@2 NA|NA|NA K PadR family transcriptional regulator KOPIJCMJ_00935 222534.KB893711_gene5073 6.4e-25 120.6 Actinobacteria Bacteria 2ECTF@1,2GR5H@201174,336QZ@2 NA|NA|NA KOPIJCMJ_00936 266940.Krad_3828 1e-124 453.8 Actinobacteria ko:K13527 ko03050,map03050 M00342 ko00000,ko00001,ko00002,ko03051 Bacteria 2IA0X@201174,COG1222@1,COG1222@2 NA|NA|NA O ATPase family associated with various cellular activities (AAA) KOPIJCMJ_00940 469383.Cwoe_1507 8.2e-30 137.1 Rubrobacteria ko:K03088 ko00000,ko03021 Bacteria 2IRNG@201174,4CTBE@84995,COG1595@1,COG1595@2 NA|NA|NA K Sigma-70 region 2 KOPIJCMJ_00941 396014.BF93_17510 3e-26 124.8 Actinobacteria ko:K02529 ko00000,ko03000 Bacteria 2GMUU@201174,COG1609@1,COG1609@2 NA|NA|NA K Periplasmic binding protein LacI transcriptional regulator KOPIJCMJ_00942 396014.BF93_17525 3.5e-09 66.2 Dermabacteraceae ko:K02026,ko:K10119 ko02010,map02010 M00196,M00207 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.28 Bacteria 2IE84@201174,4FDNP@85020,COG0395@1,COG0395@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component KOPIJCMJ_00943 396014.BF93_17530 8.6e-169 599.7 Actinobacteria Bacteria 2GJFD@201174,COG4030@1,COG4030@2 NA|NA|NA M Protein of unknown function (DUF2961) KOPIJCMJ_00944 1122998.AUHZ01000017_gene207 9.1e-77 293.9 Propionibacteriales cscK 2.7.1.4 ko:K00847 ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100 R00760,R00867,R03920 RC00002,RC00017 ko00000,ko00001,ko01000 Bacteria 2GYHF@201174,4DQSX@85009,COG0524@1,COG0524@2 NA|NA|NA G pfkB family carbohydrate kinase KOPIJCMJ_00945 1223543.GP2_032_00360 7.8e-43 179.9 Gordoniaceae Bacteria 2E7G3@1,2IQJZ@201174,331YZ@2,4GGGF@85026 NA|NA|NA KOPIJCMJ_00946 1298863.AUEP01000009_gene161 9.9e-185 653.3 Propionibacteriales malL 3.2.1.10 ko:K01182 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00801,R01718,R01791,R06199 RC00028,RC00059,RC00077,RC00451 ko00000,ko00001,ko01000 GH13 Bacteria 2GKS4@201174,4DPT7@85009,COG0366@1,COG0366@2 NA|NA|NA G Alpha-amylase domain KOPIJCMJ_00947 1121272.KB903290_gene4678 1.1e-96 360.1 Micromonosporales Bacteria 2C1EG@1,2GK4W@201174,2Z7MZ@2,4DHRJ@85008 NA|NA|NA KOPIJCMJ_00948 479432.Sros_0062 4.6e-70 271.9 Streptosporangiales tetV Bacteria 2GJPT@201174,4EJ0G@85012,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily KOPIJCMJ_00949 134676.ACPL_2692 7e-192 677.2 Micromonosporales Bacteria 28HJF@1,2ICK7@201174,2Z7UK@2,4DAVB@85008 NA|NA|NA KOPIJCMJ_00951 1386089.N865_05460 2.1e-56 224.9 Intrasporangiaceae ko:K06996 ko00000 Bacteria 2IRUY@201174,4FGZX@85021,COG3324@1,COG3324@2 NA|NA|NA S PFAM Glyoxalase bleomycin resistance protein dioxygenase KOPIJCMJ_00954 1195236.CTER_0960 1e-13 83.6 Firmicutes ko:K01163 ko00000 Bacteria 1VBBR@1239,COG1670@1,COG1670@2 NA|NA|NA J Acetyltransferase (GNAT) domain KOPIJCMJ_00955 196162.Noca_1363 1.2e-29 136.0 Propionibacteriales Bacteria 2IIQY@201174,4DR4W@85009,COG1917@1,COG1917@2 NA|NA|NA S Cupin 2, conserved barrel domain protein KOPIJCMJ_00956 1907.SGLAU_03150 8.1e-30 139.4 Actinobacteria 3.4.24.84 ko:K06013 ko00900,ko01130,map00900,map01130 R09845 RC00141 ko00000,ko00001,ko01000,ko01002,ko04147 Bacteria 2GZ0N@201174,COG0501@1,COG0501@2 NA|NA|NA O Peptidase family M48 KOPIJCMJ_00957 1172188.KB911820_gene2155 6.7e-12 77.4 Actinobacteria Bacteria 2B2RZ@1,2GVDD@201174,31VC7@2 NA|NA|NA KOPIJCMJ_00958 1394178.AWOO02000005_gene3638 0.0 1547.3 Streptosporangiales gdhB GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016638,GO:0016639,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 R00243 RC00006,RC02799 ko00000,ko00001,ko01000 Bacteria 2GK0C@201174,4EGYX@85012,COG2902@1,COG2902@2 NA|NA|NA E Bacterial NAD-glutamate dehydrogenase KOPIJCMJ_00959 1385518.N798_16970 4.7e-21 107.8 Intrasporangiaceae Bacteria 2GS2W@201174,4FGK2@85021,COG3832@1,COG3832@2 NA|NA|NA S Protein of unknown function (DUF2505) KOPIJCMJ_00960 1380370.JIBA01000014_gene2099 6.5e-18 97.4 Intrasporangiaceae Bacteria 2GS2W@201174,4FGK2@85021,COG3832@1,COG3832@2 NA|NA|NA S Protein of unknown function (DUF2505) KOPIJCMJ_00962 479433.Caci_7582 5.2e-75 288.1 Actinobacteria ko:K07001 ko00000 Bacteria 2IB0F@201174,COG1752@1,COG1752@2 NA|NA|NA S esterase of the alpha-beta hydrolase superfamily KOPIJCMJ_00963 1120950.KB892764_gene5614 3.8e-156 558.1 Propionibacteriales tgs3 GO:0000302,GO:0001666,GO:0003674,GO:0003824,GO:0004144,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0006638,GO:0006639,GO:0006641,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019432,GO:0030312,GO:0036293,GO:0040007,GO:0042221,GO:0042493,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0044464,GO:0045017,GO:0046460,GO:0046463,GO:0046486,GO:0047196,GO:0050896,GO:0051704,GO:0070482,GO:0071704,GO:0071731,GO:0071944,GO:0097366,GO:1901576,GO:1901698,GO:1901700 2.3.1.20 ko:K00635 ko00561,ko01100,map00561,map01100 M00089 R02251 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 Bacteria 2HEFF@201174,4DN7F@85009,COG1020@1,COG1020@2 NA|NA|NA Q Belongs to the long-chain O-acyltransferase family KOPIJCMJ_00967 1283299.AUKG01000001_gene3535 2.6e-38 166.0 Rubrobacteria apbE 2.7.1.180 ko:K03734 ko00000,ko01000 Bacteria 2GN6F@201174,4CSHI@84995,COG1477@1,COG1477@2 NA|NA|NA H ApbE family KOPIJCMJ_00968 47716.JOFH01000006_gene1658 2.1e-35 155.6 Actinobacteria Bacteria 2DA1Q@1,2GKR3@201174,32TUF@2 NA|NA|NA KOPIJCMJ_00969 2002.JOEQ01000007_gene1821 2.5e-68 266.2 Streptosporangiales lon ko:K07177 ko02024,map02024 ko00000,ko00001,ko01002 Bacteria 2GJDD@201174,4EFR5@85012,COG3480@1,COG3480@2 NA|NA|NA T Lon protease (S16) C-terminal proteolytic domain KOPIJCMJ_00970 58123.JOFJ01000003_gene2296 1.3e-116 426.8 Streptosporangiales Bacteria 2GJ9K@201174,4EFYY@85012,COG5282@1,COG5282@2 NA|NA|NA S Zincin-like metallopeptidase KOPIJCMJ_00971 1394178.AWOO02000039_gene8628 1.4e-30 139.8 Streptosporangiales nudJ ko:K12152 ko00000,ko01000 Bacteria 2GU6D@201174,4EIW9@85012,COG0494@1,COG0494@2 NA|NA|NA L NUDIX domain KOPIJCMJ_00972 479433.Caci_7935 7.7e-70 270.8 Actinobacteria 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 Bacteria 2I7QX@201174,COG1024@1,COG1024@2 NA|NA|NA I Belongs to the enoyl-CoA hydratase isomerase family KOPIJCMJ_00973 1504319.GM45_1925 1.6e-15 87.8 Actinobacteria Bacteria 2E479@1,2GQXY@201174,32Z35@2 NA|NA|NA KOPIJCMJ_00974 1048339.KB913029_gene2928 5.5e-157 560.8 Frankiales Bacteria 2GJQ6@201174,4ES31@85013,COG0661@1,COG0661@2 NA|NA|NA S PFAM ABC-1 domain protein KOPIJCMJ_00975 1385521.N803_02695 4e-181 641.7 Intrasporangiaceae uvrD 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 2GKRW@201174,4FFFK@85021,COG0210@1,COG0210@2 NA|NA|NA L DNA helicase KOPIJCMJ_00976 436229.JOEH01000016_gene7218 1.7e-57 229.9 Streptacidiphilus nudC 3.6.1.22 ko:K03426 ko00760,ko01100,ko04146,map00760,map01100,map04146 R00103,R03004,R11104 RC00002 ko00000,ko00001,ko01000 Bacteria 2GJZY@201174,2NF9K@228398,COG2816@1,COG2816@2 NA|NA|NA L NADH pyrophosphatase-like rudimentary NUDIX domain KOPIJCMJ_00977 1123320.KB889672_gene3701 8.6e-57 227.6 Actinobacteria Bacteria 2GP3V@201174,COG3568@1,COG3568@2 NA|NA|NA L endonuclease exonuclease phosphatase KOPIJCMJ_00978 1894.JOER01000030_gene507 4.6e-208 731.9 Actinobacteria uvrD2 3.6.4.12 ko:K03657,ko:K07465 ko03420,ko03430,map03420,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 2GM2E@201174,COG0210@1,COG0210@2,COG2887@1,COG2887@2 NA|NA|NA L Belongs to the helicase family. UvrD subfamily KOPIJCMJ_00979 73044.JNXP01000009_gene2772 3.2e-193 682.6 Actinobacteria uvrD 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 2GJD0@201174,COG0210@1,COG0210@2,COG2887@1,COG2887@2 NA|NA|NA L Belongs to the helicase family. UvrD subfamily KOPIJCMJ_00980 28444.JODQ01000008_gene1197 2.3e-140 506.5 Streptosporangiales Bacteria 2GMAV@201174,4EHD3@85012,COG0392@1,COG0392@2 NA|NA|NA I Lysylphosphatidylglycerol synthase TM region KOPIJCMJ_00981 1298863.AUEP01000002_gene1395 3.5e-19 102.1 Propionibacteriales Bacteria 29S49@1,2GWCT@201174,30D8R@2,4DVAR@85009 NA|NA|NA S TadE-like protein KOPIJCMJ_00982 1298863.AUEP01000002_gene1394 4.1e-89 335.9 Propionibacteriales Bacteria 2IAR7@201174,4DTBY@85009,COG4655@1,COG4655@2 NA|NA|NA S Putative Flp pilus-assembly TadE/G-like KOPIJCMJ_00983 1298863.AUEP01000002_gene1395 4.4e-19 101.7 Propionibacteriales Bacteria 29S49@1,2GWCT@201174,30D8R@2,4DVAR@85009 NA|NA|NA S TadE-like protein KOPIJCMJ_00984 196162.Noca_3114 1.2e-33 150.2 Propionibacteriales cpaB ko:K02279 ko00000,ko02035,ko02044 Bacteria 2INHS@201174,4DSV2@85009,COG3745@1,COG3745@2 NA|NA|NA U Flp pilus assembly protein RcpC/CpaB KOPIJCMJ_00985 1380370.JIBA01000003_gene2731 1.5e-78 300.1 Intrasporangiaceae flpE ko:K02282 ko00000,ko02035,ko02044 Bacteria 2GNHI@201174,4FG1C@85021,COG4963@1,COG4963@2 NA|NA|NA D chromosome partitioning KOPIJCMJ_00987 1160718.SU9_04396 3.4e-71 275.4 Actinobacteria Bacteria 2EXXD@1,2H2IR@201174,33R6G@2 NA|NA|NA KOPIJCMJ_00988 76114.ebA6622 2e-100 371.7 Rhodocyclales traU ko:K12060 ko00000,ko02044 3.A.7.11.1 Bacteria 1MXUA@1224,28HGF@1,2KXXZ@206389,2VKJA@28216,2Z7SA@2 NA|NA|NA S TraU protein KOPIJCMJ_00989 596154.Alide2_2814 1.7e-52 213.0 Comamonadaceae trbC ko:K12059 ko00000,ko02044 3.A.7.11.1 Bacteria 1R62Q@1224,2CIAZ@1,2VJKP@28216,2Z7YC@2,4ACDB@80864 NA|NA|NA S TIGRFAM Type-F conjugative transfer system pilin assembly protein TrbC, subgroup KOPIJCMJ_00990 232721.Ajs_1528 9.7e-118 430.6 Comamonadaceae traN ko:K12058 ko00000,ko02044 3.A.7.11.1 Bacteria 1MW96@1224,28KC1@1,2VNCU@28216,2Z9Z1@2,4AGD3@80864 NA|NA|NA S Type-1V conjugative transfer system mating pair stabilisation KOPIJCMJ_00991 84531.JMTZ01000014_gene2801 5.5e-152 545.0 Gammaproteobacteria Bacteria 1QVR5@1224,1T2HN@1236,2DBKT@1,2Z9V9@2 NA|NA|NA KOPIJCMJ_00992 1121405.dsmv_0678 2.7e-137 496.1 Proteobacteria Bacteria 1RFBU@1224,2C3RM@1,2Z9H1@2 NA|NA|NA KOPIJCMJ_00994 84531.JMTZ01000014_gene2798 7.3e-32 145.6 Bacteria Bacteria 2EK9G@1,33DZS@2 NA|NA|NA KOPIJCMJ_00995 1121405.dsmv_0684 2e-21 111.3 Proteobacteria Bacteria 1NI9Y@1224,2EX2M@1,33QDR@2 NA|NA|NA KOPIJCMJ_00996 1121918.ARWE01000001_gene1960 7.4e-43 179.9 Desulfuromonadales ilvD 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1259 Bacteria 1MUTQ@1224,2WJB7@28221,42N3P@68525,43U65@69541,COG0129@1,COG0129@2 NA|NA|NA EG Belongs to the IlvD Edd family KOPIJCMJ_00999 1003195.SCAT_1341 0.0 1076.2 Actinobacteria glnE GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0030312,GO:0031323,GO:0033238,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0060359,GO:0062012,GO:0065007,GO:0070566,GO:0071944,GO:0080090,GO:1901698 2.7.7.42,2.7.7.89 ko:K00982 ko00000,ko01000 Bacteria 2GJ91@201174,COG1391@1,COG1391@2 NA|NA|NA OT Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell KOPIJCMJ_01000 1120950.KB892707_gene4731 9.6e-218 762.7 Propionibacteriales glnA2 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0044464,GO:0050001,GO:0071944 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 Bacteria 2GJ2I@201174,4DNNP@85009,COG0174@1,COG0174@2 NA|NA|NA E glutamine synthetase KOPIJCMJ_01001 1048339.KB913029_gene4683 7.8e-220 770.0 Frankiales nadE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5,6.3.5.1 ko:K01916,ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00189,R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 Bacteria 2GK2C@201174,4ESAT@85013,COG0171@1,COG0171@2,COG0388@1,COG0388@2 NA|NA|NA H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source KOPIJCMJ_01002 1122137.AQXF01000003_gene2222 2.8e-37 162.5 Alphaproteobacteria yokD 2.3.1.81 ko:K00662 ko00000,ko01000,ko01504 Bacteria 1R68C@1224,2U1PM@28211,COG2746@1,COG2746@2 NA|NA|NA V aminoglycoside KOPIJCMJ_01003 1122611.KB903988_gene7185 2.5e-110 405.2 Streptosporangiales panB 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJP6@201174,4EGTN@85012,COG0413@1,COG0413@2 NA|NA|NA H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate KOPIJCMJ_01004 1122609.AUGT01000001_gene2813 3.9e-13 80.1 Propionibacteriales Bacteria 2EHMB@1,2I3MM@201174,33BD3@2,4DS27@85009 NA|NA|NA KOPIJCMJ_01005 68194.JNXR01000024_gene1245 3.9e-124 451.1 Actinobacteria map GO:0000096,GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0006082,GO:0006464,GO:0006508,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009066,GO:0009987,GO:0010467,GO:0016151,GO:0016485,GO:0016787,GO:0019538,GO:0019752,GO:0030145,GO:0035551,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0046872,GO:0046914,GO:0050897,GO:0051604,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0140096,GO:1901564,GO:1901605 3.4.11.18 ko:K01265 ko00000,ko01000,ko01002 Bacteria 2GKIZ@201174,COG0024@1,COG0024@2 NA|NA|NA E Methionine aminopeptidase KOPIJCMJ_01006 1123320.KB889698_gene9298 2.4e-38 165.2 Actinobacteria Bacteria 2GP6A@201174,COG1846@1,COG1846@2 NA|NA|NA K transcriptional regulator KOPIJCMJ_01008 397278.JOJN01000029_gene956 2e-138 498.8 Propionibacteriales 3.2.1.21 ko:K05349,ko:K07497 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 GH3 Bacteria 2GJ3V@201174,4DUKR@85009,COG2801@1,COG2801@2 NA|NA|NA L Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome KOPIJCMJ_01009 1504319.GM45_6105 2.3e-117 428.3 unclassified Actinobacteria (class) atpD GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 Bacteria 2GIY6@201174,3UW86@52018,COG0055@1,COG0055@2 NA|NA|NA C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits KOPIJCMJ_01010 566461.SSFG_02307 1.1e-23 116.3 Actinobacteria atpC GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 Bacteria 2IHNZ@201174,COG0355@1,COG0355@2 NA|NA|NA C Produces ATP from ADP in the presence of a proton gradient across the membrane KOPIJCMJ_01011 1144275.COCOR_04546 3.3e-61 242.7 Bacteria Bacteria COG2273@1,COG2273@2 NA|NA|NA G xyloglucan:xyloglucosyl transferase activity KOPIJCMJ_01012 1996.JOFO01000033_gene1260 3.2e-77 295.8 Actinobacteria Bacteria 2GKTW@201174,COG1216@1,COG1216@2 NA|NA|NA M Glycosyl transferase family 2 KOPIJCMJ_01013 1089544.KB912942_gene1730 5.9e-78 298.1 Pseudonocardiales Bacteria 2I92N@201174,4DXBA@85010,COG3664@1,COG3664@2 NA|NA|NA G PFAM glycoside hydrolase family 39 KOPIJCMJ_01014 797302.Halru_2865 9.3e-10 71.6 Halobacteria Archaea 23U89@183963,2XUFQ@28890,COG3919@1,arCOG06897@2157 NA|NA|NA S COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ) KOPIJCMJ_01015 526225.Gobs_0437 7.3e-45 188.3 Frankiales Bacteria 2GMYJ@201174,4EVNC@85013,COG2244@1,COG2244@2 NA|NA|NA S polysaccharide biosynthetic process KOPIJCMJ_01018 58344.JOEL01000006_gene4701 1.8e-26 127.1 Actinobacteria Bacteria 2GMYJ@201174,COG2244@1,COG2244@2 NA|NA|NA G outer membrane autotransporter barrel domain protein KOPIJCMJ_01019 1292020.H483_0102395 5.7e-181 640.6 Actinobacteria Bacteria 2GJUG@201174,COG3385@1,COG3385@2 NA|NA|NA L PFAM transposase, IS4 family protein KOPIJCMJ_01020 743718.Isova_0168 1.8e-38 165.6 Actinobacteria vsr ko:K07458 ko00000,ko01000,ko03400 Bacteria 2IKPY@201174,COG3727@1,COG3727@2 NA|NA|NA L May nick specific sequences that contain T G mispairs resulting from m5C-deamination KOPIJCMJ_01021 1304883.KI912532_gene2703 6.1e-147 527.3 Rhodocyclales dcm GO:0003674,GO:0003824,GO:0003886,GO:0006139,GO:0006259,GO:0006304,GO:0006305,GO:0006306,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009008,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0032776,GO:0034641,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044728,GO:0046483,GO:0071704,GO:0090116,GO:0090304,GO:0140097,GO:1901360 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 Bacteria 1MV9H@1224,2KX72@206389,2VIFH@28216,COG0270@1,COG0270@2 NA|NA|NA H C-5 cytosine-specific DNA methylase KOPIJCMJ_01022 398767.Glov_0293 1.1e-110 407.5 Deltaproteobacteria Bacteria 1MV6M@1224,2WIW8@28221,42M5P@68525,COG0553@1,COG0553@2 NA|NA|NA KL helicase domain protein KOPIJCMJ_01023 1174684.EBMC1_01845 3.7e-22 111.3 Sphingomonadales Bacteria 1RHFA@1224,2DUGQ@1,2K7KG@204457,2UEQK@28211,32UX8@2 NA|NA|NA L Restriction endonuclease EcoRII, N-terminal KOPIJCMJ_01024 398767.Glov_0291 6.8e-104 384.8 delta/epsilon subdivisions Bacteria 1P2C7@1224,42XB9@68525,COG0323@1,COG0323@2 NA|NA|NA L Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase KOPIJCMJ_01025 398767.Glov_0290 1.8e-39 169.9 Deltaproteobacteria ko:K07451,ko:K07453 ko00000,ko01000,ko02048 Bacteria 1MZRA@1224,2WRC6@28221,42W8N@68525,COG3183@1,COG3183@2 NA|NA|NA L PFAM HNH endonuclease KOPIJCMJ_01029 1123322.KB904676_gene3086 3e-60 238.4 Actinobacteria rimJ 2.3.1.128 ko:K03790 ko00000,ko01000,ko03009 Bacteria 2HAFI@201174,COG1670@1,COG1670@2 NA|NA|NA J N-acetyltransferase KOPIJCMJ_01030 351607.Acel_0167 9e-106 390.6 Frankiales moeA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0018315,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0032324,GO:0034641,GO:0036211,GO:0042040,GO:0042278,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0061599,GO:0070566,GO:0071704,GO:0071944,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 R09735 RC03462 ko00000,ko00001,ko01000 Bacteria 2GJC3@201174,4ERWC@85013,COG0303@1,COG0303@2 NA|NA|NA H MoeA domain protein domain I and II KOPIJCMJ_01031 593907.Celgi_0566 1.2e-94 353.2 Actinobacteria galU GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0003983,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005996,GO:0006011,GO:0006012,GO:0006073,GO:0006139,GO:0006629,GO:0006725,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009056,GO:0009058,GO:0009059,GO:0009103,GO:0009225,GO:0009242,GO:0009244,GO:0009250,GO:0009311,GO:0009312,GO:0009987,GO:0016043,GO:0016051,GO:0016052,GO:0016740,GO:0016772,GO:0016779,GO:0019318,GO:0019320,GO:0019388,GO:0022607,GO:0033499,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043933,GO:0044042,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046377,GO:0046401,GO:0046483,GO:0046872,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051748,GO:0055086,GO:0065003,GO:0070569,GO:0071704,GO:0071840,GO:1900725,GO:1900727,GO:1901135,GO:1901137,GO:1901360,GO:1901575,GO:1901576,GO:1903509 2.7.7.9,5.4.2.8 ko:K00963,ko:K01840 ko00040,ko00051,ko00052,ko00500,ko00520,ko01100,ko01110,ko01130,map00040,map00051,map00052,map00500,map00520,map01100,map01110,map01130 M00114,M00129,M00361,M00362,M00549 R00289,R01818 RC00002,RC00408 ko00000,ko00001,ko00002,ko01000 iECIAI39_1322.ECIAI39_1571,iHN637.CLJU_RS02205,iIT341.HP0646 Bacteria 2I2EW@201174,COG1210@1,COG1210@2 NA|NA|NA M Utp--glucose-1-phosphate uridylyltransferase KOPIJCMJ_01032 465515.Mlut_16430 2.4e-30 139.0 Micrococcaceae fthC 6.3.3.2 ko:K01934 ko00670,ko01100,map00670,map01100 R02301 RC00183 ko00000,ko00001,ko01000 Bacteria 1W9K2@1268,2IKWR@201174,COG0212@1,COG0212@2 NA|NA|NA H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family KOPIJCMJ_01033 298653.Franean1_0686 5.8e-18 97.1 Frankiales fmdB Bacteria 2IQHE@201174,4ET9G@85013,COG2331@1,COG2331@2 NA|NA|NA S Regulatory protein, FmdB family KOPIJCMJ_01034 1245475.ANAE01000105_gene2691 5.2e-23 114.8 Streptosporangiales cpaB ko:K02279 ko00000,ko02035,ko02044 Bacteria 2GQJH@201174,4EKC2@85012,COG3745@1,COG3745@2 NA|NA|NA U SAF KOPIJCMJ_01035 1071400.LBUCD034_0909 4.2e-20 104.4 Lactobacillaceae mscL GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066 ko:K03282 ko00000,ko02000 1.A.22.1 Bacteria 1VA14@1239,3F6YZ@33958,4HKIA@91061,COG1970@1,COG1970@2 NA|NA|NA M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell KOPIJCMJ_01037 1121272.KB903255_gene5793 1.6e-67 263.1 Micromonosporales pac ko:K07184 ko00000 Bacteria 2I2N7@201174,4DBJV@85008,COG1938@1,COG1938@2 NA|NA|NA S PAC2 family KOPIJCMJ_01038 134676.ACPL_5559 2.3e-28 134.0 Actinobacteria Bacteria 2IR52@201174,COG1525@1,COG1525@2 NA|NA|NA L Lamin Tail Domain KOPIJCMJ_01039 1380393.JHVP01000005_gene3634 1.3e-103 384.4 Frankiales ko:K07027 ko00000,ko02000 4.D.2 Bacteria 2GMAV@201174,4EU4Q@85013,COG0392@1,COG0392@2 NA|NA|NA S Lysylphosphatidylglycerol synthase TM region KOPIJCMJ_01041 1211815.CBYP010000014_gene3463 1.3e-35 157.1 Actinobacteria Bacteria 2CK5M@1,2IQNJ@201174,33W5S@2 NA|NA|NA KOPIJCMJ_01042 1304865.JAGF01000001_gene1186 3.6e-162 578.9 Actinobacteria Bacteria 2IAWA@201174,COG2199@1,COG2202@1,COG2202@2,COG3706@2 NA|NA|NA T diguanylate cyclase KOPIJCMJ_01043 446462.Amir_1335 7.9e-11 72.4 Pseudonocardiales Bacteria 2B57P@1,2I89I@201174,32TPU@2,4EECV@85010 NA|NA|NA S Protein of unknown function (DUF3052) KOPIJCMJ_01044 1123023.JIAI01000007_gene1976 5e-30 137.9 Pseudonocardiales Bacteria 2I2NF@201174,4E2P9@85010,COG1434@1,COG1434@2 NA|NA|NA S DUF218 domain KOPIJCMJ_01045 1123322.KB904724_gene2000 3.7e-131 474.9 Actinobacteria dgt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.1.5.1 ko:K01129 ko00230,map00230 R01856 RC00017 ko00000,ko00001,ko01000 Bacteria 2GJ8F@201174,COG0232@1,COG0232@2 NA|NA|NA F Deoxyguanosinetriphosphate triphosphohydrolase-like protein KOPIJCMJ_01046 675635.Psed_4581 8.5e-157 560.1 Pseudonocardiales ppdK 2.7.3.13,2.7.9.1 ko:K01006,ko:K22424 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 Bacteria 2GK73@201174,4E0F3@85010,COG0574@1,COG0574@2,COG1080@1,COG1080@2 NA|NA|NA G PEP-utilising enzyme, mobile domain KOPIJCMJ_01047 1394178.AWOO02000005_gene3609 1e-250 872.8 Streptosporangiales secA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030312,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 Bacteria 2GIRT@201174,4EGCZ@85012,COG0653@1,COG0653@2 NA|NA|NA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane KOPIJCMJ_01048 1278073.MYSTI_01666 1.2e-64 253.8 Myxococcales sua5 GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 2.7.7.87 ko:K07566 R10463 RC00745 ko00000,ko01000,ko03009,ko03016 Bacteria 1MVPM@1224,2WP34@28221,2YV20@29,42T6S@68525,COG0009@1,COG0009@2 NA|NA|NA J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine KOPIJCMJ_01053 1210046.B277_10696 3.6e-41 173.7 Intrasporangiaceae yoeB ko:K19158 ko00000,ko01000,ko02048 Bacteria 2IQAJ@201174,4FHKN@85021,COG4115@1,COG4115@2 NA|NA|NA S YoeB-like toxin of bacterial type II toxin-antitoxin system KOPIJCMJ_01054 1184607.AUCHE_20_00230 6.6e-32 142.9 Actinobacteria 2.3.1.15 ko:K08591,ko:K19159 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004,ko02048 Bacteria 2IQ6H@201174,COG2161@1,COG2161@2 NA|NA|NA D Antitoxin component of a toxin-antitoxin (TA) module KOPIJCMJ_01056 1049564.TevJSym_af00930 6.4e-80 304.7 unclassified Gammaproteobacteria phcR ko:K19622 ko02020,map02020 ko00000,ko00001,ko02022 Bacteria 1J6BK@118884,1RCW6@1224,1S3XV@1236,COG1639@1,COG1639@2,COG2204@1,COG2204@2 NA|NA|NA T HDOD domain KOPIJCMJ_01057 1121459.AQXE01000005_gene1544 4.8e-105 388.7 Desulfovibrionales Bacteria 1RCM9@1224,2MHHP@213115,2WKHK@28221,42PGC@68525,COG4191@1,COG4191@2 NA|NA|NA T Histidine kinase-like ATPases KOPIJCMJ_01059 595494.Tola_0290 2.2e-60 238.4 Gammaproteobacteria rpiB 5.3.1.6 ko:K01808 ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1604 Bacteria 1RHBF@1224,1SAUU@1236,COG0698@1,COG0698@2 NA|NA|NA G Ribose 5-phosphate isomerase KOPIJCMJ_01060 1112204.GPOL_c02910 2.3e-40 171.8 Gordoniaceae yccF Bacteria 2IKS5@201174,4GE90@85026,COG3304@1,COG3304@2 NA|NA|NA S Inner membrane component domain KOPIJCMJ_01061 398580.Dshi_3076 2.2e-09 68.9 Alphaproteobacteria greA GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006354,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0030312,GO:0031323,GO:0031326,GO:0032774,GO:0032784,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 ko:K03624 ko00000,ko03021 Bacteria 1RCXW@1224,2U5JU@28211,COG0782@1,COG0782@2 NA|NA|NA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides KOPIJCMJ_01062 1211815.CBYP010000071_gene1316 2.1e-21 110.2 Frankiales Bacteria 2AR9G@1,2GN9V@201174,31GJC@2,4EWX7@85013 NA|NA|NA S Domain of unknown function (DUF4192) KOPIJCMJ_01063 1306174.JODP01000013_gene7801 5.7e-215 753.4 Actinobacteria metY 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 iNJ661.Rv3340 Bacteria 2I2EB@201174,COG2873@1,COG2873@2 NA|NA|NA E O-acetylhomoserine KOPIJCMJ_01064 196162.Noca_2967 1.6e-27 129.0 Propionibacteriales Bacteria 2IR3G@201174,4DRRV@85009,COG0589@1,COG0589@2 NA|NA|NA T Universal stress protein family KOPIJCMJ_01065 469383.Cwoe_1650 7.6e-59 234.6 Rubrobacteria tcsS3 Bacteria 2GJ4J@201174,4CRNY@84995,COG1983@1,COG1983@2,COG4585@1,COG4585@2 NA|NA|NA T Histidine kinase-like ATPases KOPIJCMJ_01066 1211815.CBYP010000046_gene847 4.7e-64 251.1 Frankiales degU ko:K07684 ko02020,map02020 M00471 ko00000,ko00001,ko00002,ko02022 Bacteria 2GIVA@201174,4ESF0@85013,COG2197@1,COG2197@2 NA|NA|NA T Two component transcriptional regulator, LuxR family KOPIJCMJ_01068 40571.JOEA01000016_gene46 1e-30 139.4 Pseudonocardiales hinT GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019478,GO:0019752,GO:0043436,GO:0043530,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046144,GO:0046395,GO:0046416,GO:0046436,GO:0055130,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.1.1.226,2.1.1.227 ko:K02503,ko:K06442 ko00000,ko01000,ko03009,ko04147 Bacteria 2IHPT@201174,4E5MT@85010,COG0537@1,COG0537@2 NA|NA|NA FG HIT family hydrolase, diadenosine tetraphosphate hydrolase KOPIJCMJ_01069 67352.JODS01000019_gene2705 8.1e-65 253.8 Actinobacteria rsmE 1.13.12.16,2.1.1.193 ko:K00459,ko:K09761 ko00910,map00910 R00025 RC02541,RC02759 ko00000,ko00001,ko01000,ko03009 Bacteria 2GTKX@201174,COG1385@1,COG1385@2 NA|NA|NA J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit KOPIJCMJ_01070 47763.JNZA01000003_gene3958 9.9e-147 526.6 Actinobacteria dnaJ GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944 ko:K03686 ko00000,ko03029,ko03110 Bacteria 2GK69@201174,COG0484@1,COG0484@2 NA|NA|NA O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins KOPIJCMJ_01071 457425.XNR_4382 5.9e-15 86.3 Actinobacteria hrcA GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 ko:K03705 ko00000,ko03000 Bacteria 2GKF5@201174,COG1420@1,COG1420@2 NA|NA|NA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons KOPIJCMJ_01072 710696.Intca_0674 9.3e-45 186.8 Intrasporangiaceae ko:K03088 ko00000,ko03021 Bacteria 2IRNG@201174,4FH7C@85021,COG1595@1,COG1595@2 NA|NA|NA K Belongs to the sigma-70 factor family KOPIJCMJ_01073 1313172.YM304_40470 6.1e-10 71.6 Actinobacteria ko:K11748 ko00000,ko02000 2.A.37.1.2 Bacteria 2DDQ5@1,2HDNV@201174,2ZIVU@2 NA|NA|NA KOPIJCMJ_01074 882083.SacmaDRAFT_3092 9e-143 513.5 Pseudonocardiales aslB GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0019538,GO:0043170,GO:0044238,GO:0051604,GO:0071704,GO:1901564 ko:K06871 ko00000 Bacteria 2GMTV@201174,4E1AJ@85010,COG0641@1,COG0641@2 NA|NA|NA C Radical SAM superfamily KOPIJCMJ_01075 1380356.JNIK01000015_gene2367 8.8e-299 1032.7 Frankiales 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 Bacteria 2GJ8H@201174,4ETR9@85013,COG3119@1,COG3119@2 NA|NA|NA P Sulfatase KOPIJCMJ_01076 1033730.CAHG01000016_gene350 9.7e-82 311.2 Propionibacteriales ko:K03321 ko00000,ko02000 2.A.53.3 Bacteria 2GJCB@201174,4DT31@85009,COG0659@1,COG0659@2 NA|NA|NA P Sulfate permease family KOPIJCMJ_01077 1517681.HW45_14665 1e-58 233.0 Vibrionales hpt 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 Bacteria 1QJNX@1224,1THPU@1236,1XX3B@135623,COG0634@1,COG0634@2 NA|NA|NA F Phosphoribosyl transferase domain KOPIJCMJ_01081 1120949.KB903301_gene6329 2.5e-106 392.1 Micromonosporales Bacteria 2GP09@201174,4D8JX@85008,COG0111@1,COG0111@2 NA|NA|NA EH D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding KOPIJCMJ_01083 935866.JAER01000019_gene3959 1.9e-63 248.8 Propionibacteriales 3.5.1.88 ko:K01462 ko00000,ko01000 Bacteria 2HMJS@201174,4DNQP@85009,COG0242@1,COG0242@2 NA|NA|NA J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions KOPIJCMJ_01084 1504319.GM45_3080 4.5e-38 164.5 Actinobacteria ko:K03567 ko02026,map02026 ko00000,ko00001,ko03000 Bacteria 2IS2K@201174,COG2716@1,COG2716@2 NA|NA|NA E ACT domain KOPIJCMJ_01086 1906.SFRA_25950 1.2e-100 373.2 Actinobacteria ppx GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 R03409 RC00002 ko00000,ko00001,ko01000 Bacteria 2GJBN@201174,COG0248@1,COG0248@2 NA|NA|NA FP Ppx GppA phosphatase KOPIJCMJ_01087 1184609.KILIM_002_00280 1.2e-57 229.6 Dermatophilaceae ppx2 3.6.1.11,3.6.1.40 ko:K01524,ko:K09009 ko00230,map00230 R03409 RC00002 ko00000,ko00001,ko01000 Bacteria 2I8CS@201174,4F6XI@85018,COG1507@1,COG1507@2 NA|NA|NA S Protein of unknown function (DUF501) KOPIJCMJ_01088 1120950.KB892752_gene6171 4.3e-14 84.7 Propionibacteriales divIC ko:K05589,ko:K13052 ko00000,ko03036 Bacteria 2GQH7@201174,4DS5K@85009,COG2919@1,COG2919@2 NA|NA|NA D Septum formation initiator KOPIJCMJ_01089 469371.Tbis_3132 1.8e-176 625.5 Pseudonocardiales eno 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 Bacteria 2GJAY@201174,4DXDR@85010,COG0148@1,COG0148@2 NA|NA|NA G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis KOPIJCMJ_01090 1463934.JOCF01000059_gene3339 1.3e-59 236.5 Actinobacteria mazG GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0022607,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0035539,GO:0042454,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044464,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0047693,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.6.1.66 ko:K02428 ko00230,map00230 R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 Bacteria 2GNKC@201174,COG1694@1,COG3956@2 NA|NA|NA S PFAM MazG nucleotide pyrophosphohydrolase KOPIJCMJ_01092 1907.SGLAU_14165 0.0 1520.4 Actinobacteria mfd ko:K03723 ko03420,map03420 ko00000,ko00001,ko01000,ko03400 Bacteria 2GJ42@201174,COG1197@1,COG1197@2 NA|NA|NA L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site KOPIJCMJ_01093 1276756.AUEX01000003_gene705 9.8e-61 240.4 Comamonadaceae Bacteria 1MU2C@1224,2VH3V@28216,4A9PA@80864,COG5001@1,COG5001@2 NA|NA|NA T Diguanylate cyclase KOPIJCMJ_01094 1504319.GM45_5765 1.5e-91 342.4 unclassified Actinobacteria (class) clpP GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 ko00000,ko00001,ko01000,ko01002 Bacteria 2GKNK@201174,3UWGF@52018,COG0740@1,COG0740@2 NA|NA|NA O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins KOPIJCMJ_01095 1048339.KB913029_gene4876 1.7e-84 318.9 Frankiales clpP 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 ko00000,ko00001,ko01000,ko01002 Bacteria 2GK5C@201174,4ES45@85013,COG0740@1,COG0740@2 NA|NA|NA O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins KOPIJCMJ_01096 313589.JNB_05894 5.9e-103 381.3 Intrasporangiaceae tig GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944 ko:K03545 ko00000 Bacteria 2GJIG@201174,4FF93@85021,COG0544@1,COG0544@2 NA|NA|NA D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase KOPIJCMJ_01099 710696.Intca_0333 4.4e-27 128.3 Intrasporangiaceae Bacteria 2GUWM@201174,4FJA2@85021,COG1708@1,COG1708@2 NA|NA|NA L Nucleotidyltransferase domain KOPIJCMJ_01100 1121924.ATWH01000014_gene3488 5.3e-10 70.9 Microbacteriaceae Bacteria 2GYNE@201174,4FSSM@85023,COG2250@1,COG2250@2 NA|NA|NA S HEPN domain KOPIJCMJ_01101 1298863.AUEP01000019_gene3531 2e-23 115.2 Actinobacteria Bacteria 2AEBM@1,2HDPF@201174,31462@2 NA|NA|NA KOPIJCMJ_01102 1385518.N798_12125 1.6e-51 208.8 Intrasporangiaceae Bacteria 2AKGE@1,2I885@201174,30DHP@2,4FH35@85021 NA|NA|NA KOPIJCMJ_01103 1172188.KB911822_gene839 8.8e-56 223.0 Intrasporangiaceae Bacteria 298UU@1,2HY02@201174,2ZVYZ@2,4FIZB@85021 NA|NA|NA S Domain of unknown function (DU1801) KOPIJCMJ_01104 926564.KI911630_gene3158 8.1e-37 161.4 Promicromonosporaceae Bacteria 2DM4W@1,2IK0R@201174,31QNY@2,4F4T1@85017 NA|NA|NA S Winged helix DNA-binding domain KOPIJCMJ_01107 710696.Intca_2901 1.5e-38 165.2 Intrasporangiaceae higB ko:K07334 ko00000,ko02048 Bacteria 2HVCI@201174,4FJJ2@85021,COG3549@1,COG3549@2 NA|NA|NA S RelE-like toxin of type II toxin-antitoxin system HigB KOPIJCMJ_01108 367299.JOEE01000003_gene2916 5.4e-41 173.3 Intrasporangiaceae higA ko:K21498 ko00000,ko02048 Bacteria 2IR2S@201174,4FHGX@85021,COG3093@1,COG3093@2 NA|NA|NA K Helix-turn-helix XRE-family like proteins KOPIJCMJ_01109 996637.SGM_1410 5.5e-105 389.8 Actinobacteria Bacteria 2GQIV@201174,COG5635@1,COG5635@2 NA|NA|NA T Nacht domain KOPIJCMJ_01110 1048339.KB913029_gene4661 1.1e-232 812.4 Frankiales glnA GO:0001968,GO:0003674,GO:0003824,GO:0004356,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009405,GO:0009605,GO:0009607,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016020,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019222,GO:0019752,GO:0019899,GO:0020012,GO:0030162,GO:0030312,GO:0030682,GO:0031323,GO:0031325,GO:0032268,GO:0032270,GO:0035375,GO:0040007,GO:0043207,GO:0043436,GO:0044044,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046394,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0070613,GO:0071704,GO:0071944,GO:0075136,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1903317,GO:1903319 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 Bacteria 2GMN1@201174,4ES5H@85013,COG0174@1,COG0174@2 NA|NA|NA E TIGRFAM glutamine synthetase, type I KOPIJCMJ_01111 67257.JODR01000007_gene3840 1e-08 66.2 Actinobacteria Bacteria 2GKEJ@201174,COG1432@1,COG1432@2 NA|NA|NA L NYN domain KOPIJCMJ_01112 1268303.RHODMAR_0244 1.8e-20 106.3 Nocardiaceae copC ko:K07156 ko00000,ko02000 9.B.62.2 Bacteria 2GMKG@201174,4FYGB@85025,COG2372@1,COG2372@2 NA|NA|NA S CopC domain KOPIJCMJ_01113 330084.JNYZ01000035_gene9076 1.2e-108 401.0 Pseudonocardiales ko:K02351,ko:K07245 ko00000,ko02000 9.B.62.1 Bacteria 2GKIR@201174,4DXS0@85010,COG3336@1,COG3336@2 NA|NA|NA P Copper resistance KOPIJCMJ_01114 1033730.CAHG01000016_gene542 1.8e-29 137.1 Propionibacteriales Bacteria 28MY8@1,2GMYY@201174,2ZB54@2,4DNCX@85009 NA|NA|NA KOPIJCMJ_01115 365528.KB891218_gene1492 1e-153 550.1 Frankiales rarA ko:K07478 ko00000 Bacteria 2GKDP@201174,4ERXK@85013,COG2256@1,COG2256@2 NA|NA|NA L AAA ATPase, central domain protein KOPIJCMJ_01117 1048339.KB913029_gene3957 0.0 1090.5 Frankiales alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 2GIUG@201174,4ERRJ@85013,COG0013@1,COG0013@2 NA|NA|NA J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain KOPIJCMJ_01118 28444.JODQ01000017_gene6586 3.4e-42 177.9 Streptosporangiales yqgF GO:0000966,GO:0000967,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0140097,GO:1901360 ko:K07447 ko00000,ko01000 Bacteria 2IQB0@201174,4EJ6B@85012,COG0816@1,COG0816@2 NA|NA|NA L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA KOPIJCMJ_01120 196162.Noca_1067 9.6e-91 340.5 Propionibacteriales modC 2.10.1.1,3.6.3.29,3.6.3.55 ko:K02017,ko:K02018,ko:K03750,ko:K15497 ko00790,ko01100,ko02010,map00790,map01100,map02010 M00189,M00423 R09735,R10531 RC00002,RC03462 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.6.5,3.A.1.8 Bacteria 2H2JF@201174,4DPFC@85009,COG3842@1,COG3842@2 NA|NA|NA P TOBE domain KOPIJCMJ_01121 446471.Xcel_2809 8.4e-84 317.0 Promicromonosporaceae modB GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 3.6.3.29 ko:K02017,ko:K02018,ko:K15496 ko02010,map02010 M00189,M00423 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.6.5,3.A.1.8 iECO103_1326.ECO103_0752 Bacteria 2GJFB@201174,4F4A9@85017,COG4149@1,COG4149@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component KOPIJCMJ_01123 351607.Acel_0284 4.5e-222 777.3 Frankiales korA 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GKXV@201174,4ERWB@85013,COG0674@1,COG0674@2,COG1014@1,COG1014@2 NA|NA|NA C PFAM Pyruvate flavodoxin ferredoxin oxidoreductase KOPIJCMJ_01124 68260.JOAY01000024_gene1084 1.8e-150 538.9 Actinobacteria oorB 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GMI5@201174,COG1013@1,COG1013@2 NA|NA|NA C Ferredoxin oxidoreductase KOPIJCMJ_01125 1464048.JNZS01000019_gene2358 1.3e-48 200.3 Micromonosporales ko:K03294 ko00000 2.A.3.2 Bacteria 2GMFE@201174,4DD1H@85008,COG0589@1,COG0589@2 NA|NA|NA T Belongs to the universal stress protein A family KOPIJCMJ_01126 285514.JNWO01000023_gene102 1.5e-79 303.1 Actinobacteria rarD ko:K05786 ko00000,ko02000 2.A.7.7 Bacteria 2GKCP@201174,COG2962@1,COG2962@2 NA|NA|NA S RarD protein KOPIJCMJ_01127 1048339.KB913029_gene2590 2e-116 425.6 Frankiales hepS GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.5.1.30 ko:K00805 ko00900,ko01110,map00900,map01110 R09247 RC00279 ko00000,ko00001,ko01000,ko01006 Bacteria 2GMB4@201174,4ERU8@85013,COG0142@1,COG0142@2 NA|NA|NA H Belongs to the FPP GGPP synthase family KOPIJCMJ_01128 1380347.JNII01000005_gene3065 1.8e-195 688.7 Frankiales trpB 4.2.1.20 ko:K01696,ko:K06001 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 Bacteria 2GP7D@201174,4ES9G@85013,COG1350@1,COG1350@2 NA|NA|NA E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine KOPIJCMJ_01129 1123320.KB889574_gene5648 4.8e-152 544.7 Actinobacteria nuoN GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2GMGX@201174,COG1007@1,COG1007@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient KOPIJCMJ_01130 471852.Tcur_4406 5.2e-79 300.8 Streptosporangiales nuoM GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0048037,GO:0048038,GO:0048039,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1902600,GO:1990204 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 iSDY_1059.SDY_2473 Bacteria 2GKBN@201174,4EH1X@85012,COG1008@1,COG1008@2 NA|NA|NA C Proton-conducting membrane transporter KOPIJCMJ_01131 1304865.JAGF01000001_gene3337 2.2e-180 638.6 Actinobacteria 3.6.3.4 ko:K01533 R00086 RC00002 ko00000,ko01000 3.A.3.5 Bacteria 2GIRF@201174,COG2217@1,COG2217@2 NA|NA|NA P Heavy metal translocating P-type atpase KOPIJCMJ_01132 153948.NAL212_0227 1.1e-30 139.8 Nitrosomonadales Bacteria 1PE85@1224,2W92M@28216,373FB@32003,COG0500@1,COG2226@2 NA|NA|NA Q Mycolic acid cyclopropane synthetase KOPIJCMJ_01134 1033730.CAHG01000006_gene1155 4.9e-18 96.7 Propionibacteriales ko:K07213 ko04978,map04978 ko00000,ko00001 Bacteria 2GQK5@201174,4DSND@85009,COG2608@1,COG2608@2 NA|NA|NA P Heavy-metal-associated domain KOPIJCMJ_01136 1122138.AQUZ01000020_gene8292 8.2e-143 513.5 Propionibacteriales uvrB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 ko:K03702,ko:K08999 ko03420,map03420 ko00000,ko00001,ko03400 Bacteria 2GJ03@201174,4DN5W@85009,COG0556@1,COG0556@2 NA|NA|NA L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage KOPIJCMJ_01137 66373.JOFQ01000005_gene3880 7.3e-105 386.7 Actinobacteria rho GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006360,GO:0006363,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 ko:K03628 ko03018,map03018 ko00000,ko00001,ko03019,ko03021 Bacteria 2GIWY@201174,COG1158@1,COG1158@2 NA|NA|NA K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template KOPIJCMJ_01138 1449069.JMLO01000004_gene3655 1.7e-125 456.1 Nocardiaceae proP Bacteria 2I2EY@201174,4G9I9@85025,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily KOPIJCMJ_01139 471852.Tcur_3932 1.3e-28 131.7 Streptosporangiales rpmE ko:K02909 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IQ4I@201174,4EK8U@85012,COG0254@1,COG0254@2 NA|NA|NA J Binds the 23S rRNA KOPIJCMJ_01140 1449353.JQMQ01000005_gene2192 8.7e-137 493.4 Streptacidiphilus prfA ko:K02835 ko00000,ko03012 Bacteria 2GJWG@201174,2NGSW@228398,COG0216@1,COG0216@2 NA|NA|NA J PCRF KOPIJCMJ_01141 1120950.KB892745_gene2866 6.4e-67 261.2 Propionibacteriales prmC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464 2.1.1.297 ko:K02493 R10806 RC00003,RC03279 ko00000,ko01000,ko03012 Bacteria 2GMH1@201174,4DP23@85009,COG2890@1,COG2890@2 NA|NA|NA J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif KOPIJCMJ_01142 222534.KB893751_gene4143 1.2e-40 173.3 Frankiales ywlC GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 2.7.7.87 ko:K07566 R10463 RC00745 ko00000,ko01000,ko03009,ko03016 Bacteria 2GK2X@201174,4ESEK@85013,COG0009@1,COG0009@2 NA|NA|NA J Belongs to the SUA5 family KOPIJCMJ_01143 345341.KUTG_02431 3.1e-102 378.6 Pseudonocardiales Bacteria 2HNS8@201174,4EA2Q@85010,COG2152@1,COG2152@2 NA|NA|NA G beta-1,4-mannooligosaccharide phosphorylase KOPIJCMJ_01144 1121946.AUAX01000020_gene3125 1.3e-07 63.2 Actinobacteria Bacteria 2I755@201174,COG1105@1,COG1105@2 NA|NA|NA G Belongs to the carbohydrate kinase PfkB family KOPIJCMJ_01147 593907.Celgi_2506 8.4e-95 353.6 Actinobacteria Bacteria 2GMD7@201174,COG1305@1,COG1305@2 NA|NA|NA E transglutaminase KOPIJCMJ_01148 1385519.N801_09810 4.2e-164 584.3 Intrasporangiaceae Bacteria 2GS79@201174,4FF88@85021,COG3547@1,COG3547@2 NA|NA|NA L Transposase IS116/IS110/IS902 family KOPIJCMJ_01149 1184609.KILIM_005_00340 8.4e-153 547.0 Actinobacteria Bacteria 2GM8F@201174,COG3328@1,COG3328@2 NA|NA|NA L Transposase KOPIJCMJ_01150 525368.HMPREF0591_1854 8.8e-100 370.2 Mycobacteriaceae Bacteria 2374G@1762,2I9ZX@201174,COG4974@1,COG4974@2 NA|NA|NA L Belongs to the 'phage' integrase family KOPIJCMJ_01151 557599.MKAN_02490 2.7e-213 748.4 Mycobacteriaceae ko:K03733,ko:K04763 ko00000,ko03036 Bacteria 236NP@1762,2IBD6@201174,COG4974@1,COG4974@2 NA|NA|NA L Belongs to the 'phage' integrase family KOPIJCMJ_01153 1120944.JONS01000036_gene2549 1.1e-20 105.9 Actinobacteria Bacteria 2GJV7@201174,4D5Q7@85005,COG1609@1,COG1609@2 NA|NA|NA K Periplasmic binding protein domain KOPIJCMJ_01155 1123229.AUBC01000025_gene4510 1.8e-19 102.1 Bradyrhizobiaceae Bacteria 1RJ9E@1224,2AF64@1,2U9GE@28211,3154Z@2,3K5A6@41294 NA|NA|NA S Protein of unknown function (DUF2384) KOPIJCMJ_01157 1122611.KB903940_gene2058 2.3e-40 172.2 Actinobacteria Bacteria 2ICPM@201174,COG0589@1,COG0589@2 NA|NA|NA T universal stress protein KOPIJCMJ_01158 479433.Caci_6918 7.3e-112 412.5 Actinobacteria Bacteria 2GJN3@201174,COG2319@1,COG2319@2 NA|NA|NA F WD-40 repeat KOPIJCMJ_01159 68199.JNZO01000008_gene7675 4.8e-64 251.5 Bacteria Bacteria COG1073@1,COG1073@2 NA|NA|NA S thiolester hydrolase activity KOPIJCMJ_01161 1172188.KB911821_gene2084 3.5e-48 198.4 Actinobacteria Bacteria 29VND@1,2I845@201174,33797@2 NA|NA|NA KOPIJCMJ_01162 1123024.AUII01000001_gene3046 2.2e-17 95.9 Pseudonocardiales oatA GO:0000271,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016020,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509 ko:K19172 ko00000,ko02048 Bacteria 2GKI5@201174,4DZQE@85010,COG1835@1,COG1835@2,COG2755@1,COG2755@2 NA|NA|NA I Acyltransferase family KOPIJCMJ_01164 446469.Sked_28510 6.5e-120 437.6 Actinobacteria ackA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016053,GO:0016999,GO:0017000,GO:0017144,GO:0019413,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.7.2.1,2.7.2.15 ko:K00925,ko:K19697 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1034,iIT341.HP0903m,iNJ661.Rv0409 Bacteria 2GJAW@201174,COG0282@1,COG0282@2 NA|NA|NA C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction KOPIJCMJ_01165 312284.A20C1_11819 4.4e-29 134.0 Actinobacteria pta GO:0005575,GO:0005576 2.3.1.8 ko:K13788 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00230,R00921 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ5U@201174,COG0280@1,COG0280@2,COG0857@1,COG0857@2 NA|NA|NA C belongs to the CobB CobQ family KOPIJCMJ_01167 164757.Mjls_1687 1.4e-23 116.3 Mycobacteriaceae Bacteria 23A9W@1762,2DZHZ@1,2IN6I@201174,31ZDG@2 NA|NA|NA KOPIJCMJ_01168 471852.Tcur_0543 1.9e-26 127.1 Streptosporangiales Bacteria 2HCHA@201174,4EFUK@85012,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily KOPIJCMJ_01169 1068978.AMETH_3959 6.6e-108 397.1 Pseudonocardiales egtC 3.5.1.118 ko:K07008 ko00340,map00340 R11021 RC00064,RC00090 ko00000,ko00001,ko01000 Bacteria 2GXCD@201174,4DX4A@85010,COG0121@1,COG0121@2 NA|NA|NA S Glutamine amidotransferases class-II KOPIJCMJ_01170 1463857.JOFZ01000004_gene2858 1.8e-118 432.6 Actinobacteria bcsA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006629,GO:0006725,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009273,GO:0009698,GO:0009699,GO:0009714,GO:0009715,GO:0009987,GO:0016020,GO:0016043,GO:0019438,GO:0019748,GO:0022607,GO:0032991,GO:0034081,GO:0042180,GO:0042181,GO:0042546,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0071554,GO:0071704,GO:0071766,GO:0071770,GO:0071840,GO:0071944,GO:1901360,GO:1901362,GO:1901576 ko:K16167 ko00000,ko01008 Bacteria 2GV0U@201174,COG3424@1,COG3424@2 NA|NA|NA Q synthase KOPIJCMJ_01171 67281.JNZZ01000019_gene123 3.3e-49 201.4 Streptomyces griseus group ypbQ ko:K16168 ko00000,ko01008 Bacteria 2IG52@201174,41AR5@629295,COG1755@1,COG1755@2 NA|NA|NA S Isoprenylcysteine carboxyl methyltransferase (ICMT) family KOPIJCMJ_01172 105425.BBPL01000030_gene4521 2.2e-89 335.9 Streptacidiphilus srsC Bacteria 2GM2M@201174,2NGSA@228398,COG0644@1,COG0644@2 NA|NA|NA C FAD dependent oxidoreductase KOPIJCMJ_01173 28444.JODQ01000004_gene6201 2.1e-37 162.9 Streptosporangiales ubiA Bacteria 2GJT3@201174,4ENNX@85012,COG0382@1,COG0382@2 NA|NA|NA H UbiA prenyltransferase family KOPIJCMJ_01175 1246995.AFR_23530 1e-53 216.1 Micromonosporales Bacteria 2IM3K@201174,4DEGD@85008,COG0517@1,COG0517@2 NA|NA|NA S CBS domain KOPIJCMJ_01176 356851.JOAN01000011_gene5380 1.5e-67 263.5 Micromonosporales sod22 Bacteria 2GKCK@201174,4DAWY@85008,COG0025@1,COG0025@2 NA|NA|NA P Sodium/hydrogen exchanger family KOPIJCMJ_01177 512565.AMIS_58000 1.6e-49 202.6 Micromonosporales Bacteria 2HF5Y@201174,4DIXE@85008,COG5592@1,COG5592@2 NA|NA|NA S Hemerythrin HHE cation binding domain KOPIJCMJ_01178 47839.CCAU010000009_gene1334 3.9e-33 147.5 Mycobacteriaceae Bacteria 23A2K@1762,2IC9E@201174,COG2105@1,COG2105@2 NA|NA|NA S Gamma-glutamyl cyclotransferase, AIG2-like KOPIJCMJ_01179 134676.ACPL_1431 1.4e-20 106.3 Micromonosporales Bacteria 2BIEE@1,2I86Y@201174,32T9G@2,4DD6X@85008 NA|NA|NA KOPIJCMJ_01181 68260.JOAY01000028_gene4140 2.4e-15 89.0 Actinobacteria Bacteria 2EID2@1,2IG1H@201174,33C4E@2 NA|NA|NA S Protein of unknown function (DUF4245) KOPIJCMJ_01182 593907.Celgi_0687 1.9e-11 75.1 Cellulomonadaceae xseB GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494 3.1.11.6 ko:K03602 ko03430,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 2GR0U@201174,4F2SG@85016,COG1722@1,COG1722@2 NA|NA|NA L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides KOPIJCMJ_01183 321955.AAGP01000021_gene1877 6.4e-107 394.4 Brevibacteriaceae xseA GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 3.1.11.6 ko:K03601 ko03430,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 2GJAS@201174,4F8CF@85019,COG1570@1,COG1570@2 NA|NA|NA L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides KOPIJCMJ_01184 1380354.JIAN01000008_gene3433 3.2e-122 444.9 Cellulomonadaceae ispH 1.17.7.4,2.7.4.25 ko:K00945,ko:K02945,ko:K03527 ko00240,ko00900,ko01100,ko01110,ko01130,ko03010,map00240,map00900,map01100,map01110,map01130,map03010 M00052,M00096,M00178 R00158,R00512,R01665,R05884,R08210 RC00002,RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko03011 iIT341.HP0400,iLJ478.TM1444 Bacteria 2GIZ7@201174,4F107@85016,COG0761@1,COG0761@2 NA|NA|NA IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis KOPIJCMJ_01186 561175.KB894095_gene2362 1.5e-68 266.9 Streptosporangiales rmuC ko:K09760 ko00000 Bacteria 2GP4U@201174,4EHTZ@85012,COG1322@1,COG1322@2 NA|NA|NA S RmuC family KOPIJCMJ_01187 196162.Noca_1944 5.7e-58 231.1 Actinobacteria Bacteria 2ASZS@1,2IINR@201174,31IFG@2 NA|NA|NA KOPIJCMJ_01188 479433.Caci_8269 2.3e-153 548.5 Actinobacteria ychF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 ko:K06942 ko00000,ko03009 Bacteria 2GIXI@201174,COG0012@1,COG0012@2 NA|NA|NA J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner KOPIJCMJ_01189 196162.Noca_1100 2.2e-124 452.6 Propionibacteriales Bacteria 2GISN@201174,4DTGT@85009,COG0582@1,COG0582@2 NA|NA|NA L Belongs to the 'phage' integrase family KOPIJCMJ_01190 1077972.ARGLB_029_00020 1.1e-09 70.1 Bacteria Bacteria 2ECD9@1,31QH2@2 NA|NA|NA KOPIJCMJ_01191 1120950.KB892746_gene3386 6.7e-35 153.3 Actinobacteria Bacteria 29RZY@1,2IRH7@201174,30D49@2 NA|NA|NA KOPIJCMJ_01193 436229.JOEH01000009_gene4397 7.6e-81 307.4 Streptacidiphilus glpQ 3.1.4.46 ko:K01126 ko00564,map00564 R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 Bacteria 2GMMS@201174,2NI2R@228398,COG0584@1,COG0584@2 NA|NA|NA C Glycerophosphoryl diester phosphodiesterase family KOPIJCMJ_01194 172088.AUGA01000001_gene6522 8.4e-103 380.2 Bradyrhizobiaceae pheA GO:0003674,GO:0003824,GO:0004106,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 2.5.1.54,4.2.1.51,5.4.99.5 ko:K03856,ko:K04518,ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022,M00024,M00025 R00691,R01373,R01715,R01826 RC00360,RC00435,RC03116 ko00000,ko00001,ko00002,ko01000 iECNA114_1301.ECNA114_2667 Bacteria 1MU60@1224,2TSUT@28211,3JS53@41294,COG0077@1,COG0077@2 NA|NA|NA E Prephenate dehydratase KOPIJCMJ_01195 266940.Krad_0255 1.7e-41 176.8 Actinobacteria Bacteria 2GP42@201174,COG0561@1,COG0561@2 NA|NA|NA J hydrolase KOPIJCMJ_01196 253839.SSNG_03609 1e-171 609.8 Actinobacteria serS GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 2GIWP@201174,COG0172@1,COG0172@2 NA|NA|NA J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) KOPIJCMJ_01197 235985.BBPN01000034_gene854 4.6e-54 217.6 Streptacidiphilus bpa GO:0000502,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010604,GO:0016020,GO:0016043,GO:0019222,GO:0022607,GO:0022624,GO:0030162,GO:0030312,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0032268,GO:0032270,GO:0032991,GO:0042176,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0044877,GO:0045732,GO:0045862,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051259,GO:0051260,GO:0060255,GO:0061136,GO:0065003,GO:0065007,GO:0070628,GO:0071840,GO:0071944,GO:0080090,GO:1901800,GO:1902494,GO:1903050,GO:1903052,GO:1903362,GO:1903364,GO:1905368,GO:1905369 Bacteria 291ZT@1,2GR7R@201174,2NGN5@228398,2ZPJ4@2 NA|NA|NA S Protein of unknown function (DUF2587) KOPIJCMJ_01198 1313172.YM304_23820 5.1e-39 167.5 Actinobacteria ko:K07117 ko00000 Bacteria 2GQAV@201174,COG2940@1,COG2940@2 NA|NA|NA K SET domain KOPIJCMJ_01199 479431.Namu_4967 3.2e-83 315.5 Frankiales kch 3.6.1.22 ko:K03426,ko:K10716 ko00760,ko01100,ko04146,map00760,map01100,map04146 R00103,R03004,R11104 RC00002 ko00000,ko00001,ko01000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 Bacteria 2GKB8@201174,4ERFU@85013,COG1226@1,COG1226@2 NA|NA|NA P Ion channel KOPIJCMJ_01201 479433.Caci_0163 1.1e-183 649.8 Actinobacteria atuC 2.1.3.15,6.4.1.2,6.4.1.3,6.4.1.4,6.4.1.5 ko:K01966,ko:K01969,ko:K13778,ko:K18472 ko00061,ko00280,ko00281,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00281,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212 M00036,M00082,M00373,M00741 R00742,R01859,R03494,R04138,R04386 RC00040,RC00097,RC00253,RC00367,RC00609,RC00942 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIRU@201174,COG4799@1,COG4799@2 NA|NA|NA I Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta KOPIJCMJ_01203 1894.JOER01000032_gene6102 7.7e-231 806.6 Actinobacteria meaA 5.4.99.2,5.4.99.63 ko:K01847,ko:K01849,ko:K14447 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R00833,R09292 RC00395,RC02835 ko00000,ko00001,ko00002,ko01000 Bacteria 2I2N3@201174,COG2185@1,COG2185@2 NA|NA|NA I Methylmalonyl-CoA mutase KOPIJCMJ_01204 1454010.JEOE01000017_gene1266 8e-74 283.9 Cellulomonadaceae ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GN6S@201174,4F0I9@85016,COG0842@1,COG0842@2 NA|NA|NA V PFAM ABC-2 type transporter KOPIJCMJ_01205 1211815.CBYP010000045_gene812 2.6e-99 368.6 Frankiales ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GJBF@201174,4EUKR@85013,COG1131@1,COG1131@2 NA|NA|NA V AAA domain, putative AbiEii toxin, Type IV TA system KOPIJCMJ_01206 477641.MODMU_4528 1.8e-95 355.5 Frankiales nucS ko:K07503 ko00000,ko01000 Bacteria 2GIYB@201174,4ES1R@85013,COG1637@1,COG1637@2 NA|NA|NA L Cleaves both 3' and 5' ssDNA extremities of branched DNA structures KOPIJCMJ_01207 1380370.JIBA01000014_gene2048 2.9e-217 761.5 Intrasporangiaceae 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 Bacteria 2GJBM@201174,4FEPZ@85021,COG1250@1,COG1250@2 NA|NA|NA I Dehydrogenase KOPIJCMJ_01208 33876.JNXY01000008_gene8430 4.4e-74 284.6 Micromonosporales ko:K07018 ko00000 Bacteria 2GP8G@201174,4DCBM@85008,COG2945@1,COG2945@2 NA|NA|NA S hydrolase of the alpha beta KOPIJCMJ_01209 446470.Snas_1605 5.5e-23 113.2 Glycomycetales Bacteria 2E3EP@1,2GQST@201174,32YDP@2,4EZ3F@85014 NA|NA|NA S ATP- GTP-binding protein KOPIJCMJ_01210 1122611.KB903996_gene7554 1.5e-56 226.5 Streptosporangiales pcaD Bacteria 2GNFU@201174,4EFFN@85012,COG0596@1,COG0596@2 NA|NA|NA S Serine aminopeptidase, S33 KOPIJCMJ_01211 1341646.CBMO010000130_gene3119 5.2e-40 171.4 Mycobacteriaceae otsB GO:0000287,GO:0003674,GO:0003824,GO:0004805,GO:0005488,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0009058,GO:0009266,GO:0009311,GO:0009312,GO:0009409,GO:0009628,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0033554,GO:0034637,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0046351,GO:0046872,GO:0050896,GO:0051716,GO:0070413,GO:0070415,GO:0070417,GO:0071704,GO:1901576 2.4.1.15,2.4.1.347,3.1.3.12 ko:K00697,ko:K01087,ko:K16055 ko00500,ko01100,map00500,map01100 R02737,R02778 RC00005,RC00017,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 GT20 iE2348C_1286.E2348C_2018,iECED1_1282.ECED1_2163,iECIAI39_1322.ECIAI39_1155,iECS88_1305.ECS88_1952,iLF82_1304.LF82_1582,iNRG857_1313.NRG857_09495 Bacteria 233CH@1762,2I3PZ@201174,COG1877@1,COG1877@2 NA|NA|NA G Removes the phosphate from trehalose 6-phosphate to produce free trehalose KOPIJCMJ_01212 743718.Isova_2618 5e-143 514.6 Promicromonosporaceae otsA GO:0003674,GO:0003824,GO:0003825,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016311,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0016788,GO:0016791,GO:0030145,GO:0030312,GO:0033554,GO:0034637,GO:0035251,GO:0040007,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046527,GO:0046872,GO:0046914,GO:0047260,GO:0050896,GO:0051716,GO:0070413,GO:0071704,GO:0071944,GO:1901576 2.4.1.15,2.4.1.347,3.1.3.12 ko:K00697,ko:K16055 ko00500,ko01100,map00500,map01100 R02737,R02778 RC00005,RC00017,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 GT20 Bacteria 2GMX7@201174,4F40E@85017,COG0380@1,COG0380@2 NA|NA|NA G Glycosyltransferase family 20 KOPIJCMJ_01213 44060.JODL01000020_gene4906 1.1e-216 759.2 Actinobacteria 1.3.1.86 ko:K17829 ko00650,ko01120,ko01130,ko01200,map00650,map01120,map01130,map01200 R09738 RC00076 ko00000,ko00001,ko01000 Bacteria 2GKFF@201174,COG0604@1,COG0604@2 NA|NA|NA C reductase KOPIJCMJ_01214 656024.FsymDg_1521 3.4e-89 334.7 Frankiales clpX GO:0000166,GO:0000502,GO:0002020,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009376,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019899,GO:0019904,GO:0030163,GO:0030164,GO:0030312,GO:0030554,GO:0031333,GO:0031597,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0043335,GO:0044087,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0051704,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0097718,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 ko:K03544 ko04112,map04112 ko00000,ko00001,ko03110 Bacteria 2GJXQ@201174,4ERKD@85013,COG1219@1,COG1219@2 NA|NA|NA O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP KOPIJCMJ_01217 1268303.RHODMAR_2172 6.1e-20 104.0 Nocardiaceae 3.1.1.1 ko:K03928 ko00000,ko01000 Bacteria 2HJV3@201174,4G7FC@85025,COG1647@1,COG1647@2 NA|NA|NA S Serine aminopeptidase, S33 KOPIJCMJ_01218 1048339.KB913029_gene4866 7.8e-136 490.7 Frankiales folC 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJP2@201174,4ERQF@85013,COG0285@1,COG0285@2 NA|NA|NA H Mur ligase, middle domain protein KOPIJCMJ_01219 1120936.KB907209_gene1847 6.3e-11 73.6 Bacteria Bacteria 2EHND@1,33BE5@2 NA|NA|NA S Protein of unknown function (DUF4233) KOPIJCMJ_01220 1380356.JNIK01000001_gene2188 3.8e-48 197.6 Frankiales ndk GO:0003674,GO:0003824,GO:0004518,GO:0004550,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006464,GO:0006468,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016787,GO:0016788,GO:0018995,GO:0019205,GO:0019538,GO:0019637,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0034641,GO:0036211,GO:0042025,GO:0043170,GO:0043412,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044464,GO:0046483,GO:0046777,GO:0046939,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072527,GO:0090304,GO:0090305,GO:1901360,GO:1901564 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 iNJ661.Rv2445c Bacteria 2IFBU@201174,4ESUM@85013,COG0105@1,COG0105@2 NA|NA|NA F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate KOPIJCMJ_01221 543632.JOJL01000008_gene5922 1.1e-120 439.9 Micromonosporales ppk2 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008976,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0044237 2.7.4.1 ko:K22468 ko00190,ko03018,map00190,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 2GKRN@201174,4DBU4@85008,COG2326@1,COG2326@2 NA|NA|NA S Polyphosphate kinase 2 (PPK2) KOPIJCMJ_01222 471852.Tcur_1544 3.9e-300 1036.9 Streptosporangiales Bacteria 2GJY1@201174,4EFRZ@85012,COG1032@1,COG1032@2 NA|NA|NA C Elongator protein 3, MiaB family, Radical SAM KOPIJCMJ_01223 1380356.JNIK01000001_gene2193 6.2e-65 254.2 Frankiales Bacteria 2GIS7@201174,4ESGF@85013,COG5011@1,COG5011@2 NA|NA|NA S Uncharacterized protein conserved in bacteria (DUF2344) KOPIJCMJ_01224 561175.KB894104_gene1142 5.4e-213 748.0 Streptosporangiales rne GO:0006139,GO:0006364,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 3.1.26.12 ko:K08300,ko:K08301 ko03018,map03018 M00394 ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 Bacteria 2GMM5@201174,4EGIT@85012,COG1530@1,COG1530@2 NA|NA|NA J Ribonuclease E/G family KOPIJCMJ_01225 1048339.KB913029_gene4852 1.3e-32 145.6 Frankiales rplU GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02888 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IQ9A@201174,4ET3X@85013,COG0261@1,COG0261@2 NA|NA|NA J This protein binds to 23S rRNA in the presence of protein L20 KOPIJCMJ_01226 471856.Jden_1651 6.7e-35 152.9 Actinobacteria rpmA GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904 ko:K02899 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IQDI@201174,COG0211@1,COG0211@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL27 family KOPIJCMJ_01227 1123322.KB904724_gene1934 3.6e-179 634.8 Actinobacteria obg GO:0000287,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0032991,GO:0036211,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046777,GO:0046872,GO:0071704,GO:0071944,GO:1901564,GO:1990904 ko:K03979 ko00000,ko01000,ko03009 Bacteria 2GISB@201174,COG0536@1,COG0536@2 NA|NA|NA S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control KOPIJCMJ_01228 105425.BBPL01000002_gene6561 4.3e-124 451.4 Streptacidiphilus proB GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 Bacteria 2GM8U@201174,2NG7R@228398,COG0263@1,COG0263@2 NA|NA|NA E Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase KOPIJCMJ_01229 500153.JOEK01000011_gene1945 1.3e-155 556.2 Actinobacteria proA GO:0003674,GO:0003824,GO:0004350,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016620,GO:0016903,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 iLJ478.TM0293,iNJ661.Rv2427c,iYO844.BSU13130 Bacteria 2GISA@201174,COG0014@1,COG0014@2 NA|NA|NA E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate KOPIJCMJ_01231 1123024.AUII01000008_gene1827 3.9e-75 287.7 Pseudonocardiales nadD GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18,3.6.1.55 ko:K00969,ko:K03574 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 Bacteria 2GMFZ@201174,4E0CB@85010,COG1057@1,COG1057@2 NA|NA|NA H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) KOPIJCMJ_01232 351607.Acel_0763 4.2e-44 185.7 Frankiales Bacteria 2GNGN@201174,4EWPJ@85013,COG1316@1,COG1316@2 NA|NA|NA K LytR cell envelope-related transcriptional attenuator KOPIJCMJ_01233 1306174.JODP01000011_gene6740 3e-39 167.9 Actinobacteria rsfS GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113 2.7.7.18 ko:K00969,ko:K09710 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000,ko03009 Bacteria 2IKZ3@201174,COG0799@1,COG0799@2 NA|NA|NA S Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation KOPIJCMJ_01234 253839.SSNG_02327 7.5e-57 227.3 Actinobacteria gpmB GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0044237 3.1.3.73,3.1.3.85 ko:K02226,ko:K22306 ko00860,ko01100,map00860,map01100 M00122 R04594,R11173 RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJYU@201174,COG0406@1,COG0406@2 NA|NA|NA G Belongs to the phosphoglycerate mutase family KOPIJCMJ_01236 1380354.JIAN01000009_gene3895 1.3e-12 79.3 Actinobacteria Bacteria 2EGDD@1,2GR3X@201174,33A58@2 NA|NA|NA S Phospholipase_D-nuclease N-terminal KOPIJCMJ_01237 1504319.GM45_5885 0.0 1257.3 unclassified Actinobacteria (class) leuS 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 Bacteria 2GJI1@201174,3UWBT@52018,COG0495@1,COG0495@2 NA|NA|NA J Leucyl-tRNA synthetase, Domain 2 KOPIJCMJ_01238 1289387.AUKW01000018_gene2044 8.5e-63 247.3 Actinobacteria Bacteria 2GIUV@201174,COG1307@1,COG1307@2 NA|NA|NA S DegV family KOPIJCMJ_01239 1386089.N865_01635 1.8e-35 156.0 Intrasporangiaceae plsY 2.3.1.15 ko:K03977,ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004,ko03009 Bacteria 2IF8Y@201174,4FG1E@85021,COG0344@1,COG0344@2 NA|NA|NA I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP KOPIJCMJ_01240 1122138.AQUZ01000017_gene6611 6e-28 131.3 Propionibacteriales comEA ko:K02237 M00429 ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 Bacteria 2IQDC@201174,4DRFZ@85009,COG1555@1,COG1555@2 NA|NA|NA L Helix-hairpin-helix motif KOPIJCMJ_01241 994479.GL877878_gene2770 1.9e-94 354.0 Pseudonocardiales comEC ko:K02238 M00429 ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 Bacteria 2GJGR@201174,4DXGV@85010,COG0658@1,COG0658@2,COG2333@1,COG2333@2 NA|NA|NA S DNA internalization-related competence protein ComEC Rec2 KOPIJCMJ_01242 479433.Caci_7073 3.3e-41 176.0 Actinobacteria holA 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 2GNMZ@201174,COG1466@1,COG1466@2 NA|NA|NA L DNA polymerase III delta subunit KOPIJCMJ_01243 675635.Psed_2013 4.5e-23 113.6 Pseudonocardiales rpsT GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030234,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0042979,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050790,GO:0065003,GO:0065007,GO:0065009,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02968 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IQ73@201174,4E5HA@85010,COG0268@1,COG0268@2 NA|NA|NA J Binds directly to 16S ribosomal RNA KOPIJCMJ_01244 2074.JNYD01000002_gene5415 6.6e-35 156.0 Pseudonocardiales ko:K03556 ko00000,ko03000 Bacteria 2IBM2@201174,4E973@85010,COG2197@1,COG2197@2,COG2909@1,COG2909@2 NA|NA|NA KT helix_turn_helix, Lux Regulon KOPIJCMJ_01245 1246995.AFR_16520 5.2e-141 508.4 Micromonosporales 2.4.1.12 ko:K00694 ko00500,ko01100,ko02026,map00500,map01100,map02026 R02889 RC00005 ko00000,ko00001,ko01000,ko01003,ko02000 4.D.3.1.2,4.D.3.1.5,4.D.3.1.6 GT2 Bacteria 2GKFI@201174,4D8PJ@85008,COG1215@1,COG1215@2 NA|NA|NA M Glycosyltransferases, probably involved in cell wall biogenesis KOPIJCMJ_01246 1003195.SCAT_3111 5.4e-84 317.8 Actinobacteria gyrA GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0008094,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0034335,GO:0042623,GO:0061505,GO:0140097 5.99.1.3 ko:K02469 ko00000,ko01000,ko03032,ko03400 Bacteria 2GJ2Q@201174,COG0188@1,COG0188@2 NA|NA|NA L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner KOPIJCMJ_01247 1283287.KB822575_gene768 6.4e-21 107.8 Propionibacteriales GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 Bacteria 2GKZP@201174,4DR9G@85009,COG3266@1,COG3266@2 NA|NA|NA S Transmembrane domain of unknown function (DUF3566) KOPIJCMJ_01251 1203605.HMPREF1531_01896 3e-63 248.1 Propionibacteriales ppiA GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0030312,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0071704,GO:0071944,GO:0140096,GO:1901564 5.2.1.8 ko:K01802,ko:K03767,ko:K03768 ko01503,ko04217,map01503,map04217 ko00000,ko00001,ko01000,ko03110,ko04147 Bacteria 2IFUE@201174,4DQA4@85009,COG0652@1,COG0652@2 NA|NA|NA O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides KOPIJCMJ_01252 1122611.KB903952_gene5829 4.1e-40 171.8 Streptosporangiales gluP 3.4.21.105 ko:K19225 ko00000,ko01000,ko01002 Bacteria 2GJYG@201174,4EH62@85012,COG0705@1,COG0705@2 NA|NA|NA S Rhomboid family KOPIJCMJ_01253 2002.JOEQ01000029_gene8208 9.9e-15 85.9 Streptosporangiales crgA Bacteria 2E4NY@1,2HZN4@201174,32ZHR@2,4EKK3@85012 NA|NA|NA D Involved in cell division KOPIJCMJ_01254 1193181.BN10_150004 1e-42 180.3 Intrasporangiaceae Bacteria 2GJ9Y@201174,4FFV4@85021,COG3879@1,COG3879@2 NA|NA|NA S Bacterial protein of unknown function (DUF881) KOPIJCMJ_01255 1123320.KB889730_gene5990 6e-77 293.9 Actinobacteria trpG GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 2.6.1.85 ko:K01664,ko:K13950 ko00790,map00790 R01716 RC00010,RC01418 ko00000,ko00001,ko01000 Bacteria 2GJUX@201174,COG0512@1,COG0512@2 NA|NA|NA EH Glutamine amidotransferase of anthranilate synthase KOPIJCMJ_01256 1463926.JOCA01000003_gene5189 2.6e-123 448.7 Actinobacteria ybdL GO:0003674,GO:0003824,GO:0005488,GO:0008144,GO:0008483,GO:0010326,GO:0016740,GO:0016769,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.6.1.17,2.6.1.88 ko:K14267,ko:K14287 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04475,R08618 RC00006,RC00025 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 2GJ7R@201174,COG0436@1,COG0436@2 NA|NA|NA E Aminotransferase KOPIJCMJ_01257 1193181.BN10_800007 3.2e-72 278.5 Intrasporangiaceae ko:K07124 ko00000 Bacteria 2GKJE@201174,4FFCH@85021,COG0300@1,COG0300@2 NA|NA|NA S Belongs to the short-chain dehydrogenases reductases (SDR) family KOPIJCMJ_01258 1120936.KB907212_gene5233 1.9e-12 79.3 Streptosporangiales 2.3.1.43 ko:K00650 ko00564,ko04979,map00564,map04979 R02114 RC00037,RC00055 ko00000,ko00001,ko01000 Bacteria 2IAEU@201174,4EQDC@85012,COG1075@1,COG1075@2 NA|NA|NA S acetyltransferases and hydrolases with the alpha beta hydrolase fold KOPIJCMJ_01259 1003195.SCAT_3322 1.6e-70 272.3 Actinobacteria pyrE 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 iJN678.umpS Bacteria 2GKUQ@201174,COG0461@1,COG0461@2 NA|NA|NA F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) KOPIJCMJ_01260 1179773.BN6_83110 6.7e-71 273.9 Pseudonocardiales dedA ko:K03975 ko00000 Bacteria 2GKGR@201174,4DX3S@85010,COG0586@1,COG0586@2 NA|NA|NA S SNARE associated Golgi protein KOPIJCMJ_01261 465515.Mlut_02030 2.8e-71 275.0 Micrococcaceae spoU 2.1.1.185 ko:K03218,ko:K03437 ko00000,ko01000,ko03009,ko03016 Bacteria 1W7E6@1268,2GM1A@201174,COG0566@1,COG0566@2 NA|NA|NA J rRNA methyltransferase KOPIJCMJ_01263 1179773.BN6_01060 2.4e-55 221.9 Pseudonocardiales ftn 1.16.3.1,1.16.3.2 ko:K02217,ko:K22336 ko00860,map00860 R00078 RC02758 ko00000,ko00001,ko01000 Bacteria 2IG5S@201174,4E2T6@85010,COG1528@1,COG1528@2 NA|NA|NA P Iron-storage protein KOPIJCMJ_01265 1380370.JIBA01000015_gene330 9e-26 122.9 Actinobacteria Bacteria 2IRGU@201174,COG1846@1,COG1846@2 NA|NA|NA K transcriptional KOPIJCMJ_01267 710696.Intca_0352 6.5e-50 203.4 Intrasporangiaceae ko:K07341 ko00000,ko02048 Bacteria 2IR34@201174,4FHP3@85021,COG3654@1,COG3654@2 NA|NA|NA S Fic/DOC family KOPIJCMJ_01268 1386089.N865_20845 4.2e-21 106.7 Bacteria Bacteria 2EM5W@1,33EV5@2 NA|NA|NA KOPIJCMJ_01269 1193181.BN10_1280004 2.2e-47 195.3 Intrasporangiaceae Bacteria 2IFJT@201174,4FGZW@85021,COG3832@1,COG3832@2 NA|NA|NA S Polyketide cyclase / dehydrase and lipid transport KOPIJCMJ_01270 861360.AARI_35180 2.9e-115 422.2 Micrococcaceae Bacteria 1WB05@1268,2GJK7@201174,COG3464@1,COG3464@2 NA|NA|NA L 4.5 Transposon and IS KOPIJCMJ_01271 234267.Acid_3077 4.8e-251 874.4 Acidobacteria ko:K15314 ko01059,ko01130,map01059,map01130 M00824,M00825 R11435 ko00000,ko00001,ko00002,ko01008 Bacteria 3Y347@57723,COG0304@1,COG0304@2,COG3321@1,COG3321@2,COG4221@1,COG4221@2 NA|NA|NA Q Acyl transferase domain KOPIJCMJ_01275 58344.JOEL01000008_gene1598 6.3e-90 337.4 Actinobacteria trpH GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004534,GO:0004536,GO:0004540,GO:0005488,GO:0006139,GO:0006259,GO:0006521,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008409,GO:0009987,GO:0010565,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016796,GO:0016895,GO:0016896,GO:0019222,GO:0030145,GO:0031323,GO:0033238,GO:0034641,GO:0035312,GO:0042578,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0090357,GO:0090501,GO:0090503,GO:0097657,GO:0140097,GO:0140098,GO:1901360 3.1.3.97 ko:K07053 R00188,R11188 RC00078 ko00000,ko01000 Bacteria 2GIZ5@201174,COG0613@1,COG0613@2 NA|NA|NA S Protein of unknown function (DUF3097) KOPIJCMJ_01276 1123508.JH636440_gene2073 5.8e-09 67.8 Planctomycetes Bacteria 2J1MD@203682,COG2314@1,COG2314@2 NA|NA|NA S TM2 domain KOPIJCMJ_01277 1120950.KB892739_gene4000 4e-130 471.5 Propionibacteriales hemN GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 iNJ661.Rv2388c Bacteria 2GJXX@201174,4DN32@85009,COG0635@1,COG0635@2 NA|NA|NA H Involved in the biosynthesis of porphyrin-containing compound KOPIJCMJ_01280 1304865.JAGF01000001_gene735 2.9e-118 431.8 Cellulomonadaceae ddhD Bacteria 2GKW0@201174,4F0TD@85016,COG0673@1,COG0673@2 NA|NA|NA S PFAM oxidoreductase domain protein KOPIJCMJ_01281 1454010.JEOE01000011_gene2396 7.7e-129 468.0 Actinobacteria Bacteria 2IBWT@201174,COG4425@1,COG4425@2 NA|NA|NA S Alpha/beta-hydrolase family KOPIJCMJ_01282 1043493.BBLU01000007_gene25 5.2e-190 670.6 Actinobacteria ugp 2.7.7.9 ko:K00963 ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130 M00129,M00361,M00362,M00549 R00289 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 2I2G3@201174,COG4284@1,COG4284@2 NA|NA|NA G UTP-glucose-1-phosphate uridylyltransferase KOPIJCMJ_01283 1380354.JIAN01000008_gene3362 1.9e-29 136.7 Actinobacteria 3.2.1.91 ko:K19668 ko00500,ko01100,ko02020,map00500,map01100,map02020 R02886,R11308 RC00799 ko00000,ko00001,ko01000 GH6 Bacteria 2GN7G@201174,COG3291@1,COG3291@2,COG3420@1,COG3420@2 NA|NA|NA P PFAM PKD domain containing protein KOPIJCMJ_01284 397278.JOJN01000002_gene388 1.8e-19 102.1 Propionibacteriales lsr Bacteria 2C4MW@1,2IQ6A@201174,32RKK@2,4DRM6@85009 NA|NA|NA S Lsr2 KOPIJCMJ_01285 1050202.KB913024_gene1971 2e-50 207.2 Actinopolysporales sigB GO:0000988,GO:0000990,GO:0003674,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0043620,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141 ko:K03090 ko00000,ko03021 Bacteria 2GKSY@201174,407GP@622450,COG1191@1,COG1191@2 NA|NA|NA K Sigma-70 region 3 KOPIJCMJ_01289 1386089.N865_11320 1.9e-99 369.8 Intrasporangiaceae Bacteria 2GN56@201174,4FFV2@85021,COG1835@1,COG1835@2 NA|NA|NA I Acyltransferase family KOPIJCMJ_01290 585531.HMPREF0063_10523 3.9e-28 131.3 Propionibacteriales gltB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 Bacteria 2GN09@201174,4DP8G@85009,COG0067@1,COG0067@2,COG0069@1,COG0069@2 NA|NA|NA E GXGXG motif KOPIJCMJ_01291 479433.Caci_6448 2.9e-34 151.4 Actinobacteria Bacteria 2F0VE@1,2INWW@201174,33TX8@2 NA|NA|NA KOPIJCMJ_01292 446471.Xcel_0031 3.2e-111 408.7 Actinobacteria Bacteria 2GWBV@201174,COG1672@1,COG1672@2 NA|NA|NA S AAA ATPase domain KOPIJCMJ_01293 1122599.AUGR01000005_gene1973 2.5e-126 459.1 Oceanospirillales Bacteria 1MWUX@1224,1RQ8G@1236,1XK8Z@135619,COG0076@1,COG0076@2 NA|NA|NA E Glutamate decarboxylase and related PLP-dependent KOPIJCMJ_01294 479435.Kfla_0655 1.4e-35 155.6 Propionibacteriales Bacteria 2IKXW@201174,4DR3R@85009,COG3824@1,COG3824@2 NA|NA|NA S Zincin-like metallopeptidase KOPIJCMJ_01295 1121272.KB903289_gene4351 1.8e-95 355.9 Actinobacteria Bacteria 2IB3X@201174,COG5640@1,COG5640@2 NA|NA|NA O Trypsin-like serine protease KOPIJCMJ_01296 1137268.AZXF01000013_gene1613 6.2e-33 147.5 Streptosporangiales ybdK GO:0003674,GO:0003824,GO:0016874,GO:0016879 ko:K06048 ko00000,ko01000 Bacteria 2GKAA@201174,4EI4B@85012,COG2170@1,COG2170@2 NA|NA|NA S ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity KOPIJCMJ_01297 1304865.JAGF01000001_gene1186 6.4e-155 555.1 Actinobacteria Bacteria 2IAWA@201174,COG2199@1,COG2202@1,COG2202@2,COG3706@2 NA|NA|NA T diguanylate cyclase KOPIJCMJ_01298 1380356.JNIK01000013_gene4301 2.1e-50 204.9 Frankiales Bacteria 2GR1G@201174,4EWZ9@85013,COG3631@1,COG3631@2 NA|NA|NA S SnoaL-like polyketide cyclase KOPIJCMJ_01299 1380370.JIBA01000006_gene3355 3.3e-83 314.7 Intrasporangiaceae ko:K07118 ko00000 Bacteria 2GK2P@201174,4FH0H@85021,COG2910@1,COG2910@2 NA|NA|NA S NAD(P)H-binding KOPIJCMJ_01300 1380370.JIBA01000011_gene3042 3.5e-135 488.0 Intrasporangiaceae Bacteria 299PK@1,2ICYR@201174,2ZWRX@2,4FEZK@85021 NA|NA|NA S Rifampin ADP-ribosyl transferase KOPIJCMJ_01301 1380393.JHVP01000015_gene4172 2.1e-58 231.9 Frankiales 3.2.2.1 ko:K01239 ko00230,ko00760,ko01100,map00230,map00760,map01100 R01245,R01273,R01677,R01770,R02143 RC00033,RC00063,RC00122,RC00318,RC00485 ko00000,ko00001,ko01000 Bacteria 2IFKS@201174,4EVNQ@85013,COG0346@1,COG0346@2 NA|NA|NA E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily KOPIJCMJ_01302 1385520.N802_03220 2.4e-261 908.7 Intrasporangiaceae vpr GO:0005575,GO:0005576 ko:K14647 ko02024,map02024 ko00000,ko00001,ko01000,ko01002,ko03110 Bacteria 2GK3D@201174,4FE2Y@85021,COG1404@1,COG1404@2 NA|NA|NA O PA domain KOPIJCMJ_01303 1281779.H009_15174 6.1e-153 547.0 Rhizobiaceae yqjG 1.8.5.7,2.5.1.18 ko:K00799,ko:K07393 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 Bacteria 1MV50@1224,2TRDE@28211,4B85J@82115,COG0435@1,COG0435@2 NA|NA|NA O Glutathione S-transferase, C-terminal domain KOPIJCMJ_01304 1038858.AXBA01000014_gene2168 2.1e-23 114.8 Xanthobacteraceae 1.13.11.2 ko:K07104 ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220 M00569 R00816,R04089,R05295,R05404,R05406,R07795 RC00387,RC00643,RC01075,RC01364,RC01914 ko00000,ko00001,ko00002,ko01000 Bacteria 1RC4S@1224,2TTYI@28211,3EZFN@335928,COG2514@1,COG2514@2 NA|NA|NA S Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily KOPIJCMJ_01305 1304865.JAGF01000001_gene2578 5.7e-07 60.5 Actinobacteria Bacteria 2IF8Q@201174,COG1287@1,COG1287@2 NA|NA|NA S oligosaccharyl transferase activity KOPIJCMJ_01306 1304865.JAGF01000001_gene1494 2.3e-33 148.3 Actinobacteria Bacteria 2IKRD@201174,COG3795@1,COG3795@2 NA|NA|NA S PFAM YCII-related KOPIJCMJ_01307 287986.DV20_29020 6.4e-23 113.6 Pseudonocardiales Bacteria 2IKRD@201174,4E51J@85010,COG3795@1,COG3795@2 NA|NA|NA S YCII-related domain KOPIJCMJ_01308 477641.MODMU_1471 5.7e-127 461.1 Frankiales ko:K03088 ko00000,ko03021 Bacteria 2GJ36@201174,4ES50@85013,COG4941@1,COG4941@2 NA|NA|NA K TIGRFAM RNA polymerase sigma factor, sigma-70 family KOPIJCMJ_01310 357809.Cphy_2216 1.6e-22 113.6 Lachnoclostridium ko:K07452,ko:K09384 ko00000,ko01000,ko02048 Bacteria 1U8TV@1239,223CF@1506553,258B5@186801,COG0470@1,COG0470@2 NA|NA|NA L DNA polymerase III KOPIJCMJ_01312 1283283.ATXA01000001_gene544 8e-35 153.7 Frankiales Bacteria 2IN6K@201174,4ETDQ@85013,COG1714@1,COG1714@2 NA|NA|NA S RDD family KOPIJCMJ_01313 471852.Tcur_2987 1.8e-117 429.5 Streptosporangiales 1.11.1.19 ko:K15733 ko00000,ko01000 Bacteria 2GIUB@201174,4EICS@85012,COG2837@1,COG2837@2 NA|NA|NA P Dyp-type peroxidase family KOPIJCMJ_01314 749414.SBI_01457 4.3e-37 161.8 Actinobacteria ycgQ ko:K08986 ko00000 Bacteria 2GZEU@201174,COG3689@1,COG3689@2 NA|NA|NA S TIGRFAM TIGR03943 family protein KOPIJCMJ_01315 1463881.KL591026_gene2615 3.9e-63 248.1 Actinobacteria ycgR ko:K07089 ko00000 Bacteria 2GJQ0@201174,COG0701@1,COG0701@2 NA|NA|NA P permease KOPIJCMJ_01316 1463887.KL589971_gene4547 2.5e-15 88.2 Actinobacteria ycgR ko:K07089 ko00000 Bacteria 2GJQ0@201174,COG0701@1,COG0701@2 NA|NA|NA P permease KOPIJCMJ_01317 350058.Mvan_3810 1.7e-306 1058.5 Mycobacteriaceae pacL2 3.6.3.8 ko:K01537 ko00000,ko01000 3.A.3.2 Bacteria 232MQ@1762,2GJJC@201174,COG0474@1,COG0474@2 NA|NA|NA P ATPase, P-type (transporting), HAD superfamily, subfamily IC KOPIJCMJ_01318 1385520.N802_11095 6.2e-88 330.5 Actinobacteria Bacteria 2AAWD@1,2IG0D@201174,3109H@2 NA|NA|NA S Alkylmercury lyase KOPIJCMJ_01319 446471.Xcel_1838 5.3e-63 247.7 Actinobacteria flpA 4.1.99.16,4.2.3.22,4.2.3.75 ko:K10187,ko:K21562 ko00909,ko01100,ko01110,map00909,map01100,map01110 R07647,R07648,R08543,R09487 RC01832,RC02159,RC02160,RC02183,RC02425,RC02552 ko00000,ko00001,ko01000,ko03000 Bacteria 2IKTT@201174,COG0664@1,COG0664@2 NA|NA|NA K cyclic nucleotide-binding KOPIJCMJ_01320 1123377.AUIV01000044_gene1935 3.3e-58 231.5 Proteobacteria Bacteria 1RGVE@1224,31KIR@2,arCOG11509@1 NA|NA|NA KOPIJCMJ_01321 446471.Xcel_1836 6e-33 147.5 Actinobacteria 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 ko00000,ko00001,ko01000,ko01002 Bacteria 2GXS7@201174,COG0681@1,COG0681@2 NA|NA|NA U Peptidase S24-like KOPIJCMJ_01323 350058.Mvan_1143 1.2e-81 311.6 Mycobacteriaceae Bacteria 234MG@1762,2GMRR@201174,COG3012@1,COG3012@2 NA|NA|NA S SEC-C motif KOPIJCMJ_01324 931627.MycrhDRAFT_2049 1.6e-171 609.4 Mycobacteriaceae ko:K03294,ko:K03758 ko00000,ko02000 2.A.3.2 Bacteria 23D1J@1762,2H2J4@201174,COG0531@1,COG0531@2 NA|NA|NA E Amino acid permease KOPIJCMJ_01325 1449976.KALB_791 1.9e-39 170.2 Pseudonocardiales 3.1.1.85 ko:K02170,ko:K06889 ko00780,ko01100,map00780,map01100 M00572 R09725 RC00460,RC00461 ko00000,ko00001,ko00002,ko01000 Bacteria 2GMK3@201174,4E10C@85010,COG1073@1,COG1073@2 NA|NA|NA S Prolyl oligopeptidase family KOPIJCMJ_01326 1146883.BLASA_4759 1.9e-66 259.6 Frankiales Bacteria 2GKVT@201174,4EWMM@85013,COG0697@1,COG0697@2 NA|NA|NA EG EamA-like transporter family KOPIJCMJ_01327 1128421.JAGA01000002_gene560 3.9e-22 112.1 unclassified Bacteria 3.5.1.106 ko:K15357 ko00760,ko01120,map00760,map01120 M00622 R09126 RC00323,RC02431 ko00000,ko00001,ko00002,ko01000 Bacteria 2NQB7@2323,COG2267@1,COG2267@2 NA|NA|NA I Alpha/beta hydrolase family KOPIJCMJ_01328 675635.Psed_2022 3e-79 302.0 Pseudonocardiales Bacteria 2GKX1@201174,4E1RE@85010,COG1718@1,COG1718@2 NA|NA|NA DT Serine threonine protein kinase involved in cell cycle control KOPIJCMJ_01329 100226.SCO1348 2.5e-30 138.3 Actinobacteria Bacteria 2CP0Z@1,2IHXV@201174,32SI8@2 NA|NA|NA S Protein of unknown function (DUF3037) KOPIJCMJ_01332 1121927.GOHSU_25_00640 2.7e-99 368.2 Gordoniaceae pntB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008746,GO:0008750,GO:0009117,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016652,GO:0019362,GO:0019637,GO:0031224,GO:0031226,GO:0034641,GO:0036094,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050661,GO:0050662,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072524,GO:0097159,GO:1901265,GO:1901360,GO:1901363,GO:1901564 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 R00112 RC00001 ko00000,ko00001,ko01000 iSBO_1134.SBO_1534,iYL1228.KPN_01527 Bacteria 2GNKB@201174,4GBTV@85026,COG1282@1,COG1282@2 NA|NA|NA C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane KOPIJCMJ_01333 196162.Noca_4337 8.8e-114 416.8 Propionibacteriales purC GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6,6.3.4.13 ko:K01923,ko:K01945,ko:K03566 ko00230,ko01100,ko01110,ko01130,ko02026,map00230,map01100,map01110,map01130,map02026 M00048 R04144,R04591 RC00064,RC00090,RC00162,RC00166 ko00000,ko00001,ko00002,ko01000,ko03000 Bacteria 2GK3H@201174,4DP92@85009,COG0152@1,COG0152@2 NA|NA|NA F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL KOPIJCMJ_01334 105425.BBPL01000013_gene1809 4e-198 697.6 Streptacidiphilus purB 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKBR@201174,2NGEH@228398,COG0015@1,COG0015@2 NA|NA|NA F Adenylosuccinate lyase C-terminus KOPIJCMJ_01335 1048339.KB913029_gene1446 3.9e-152 544.7 Frankiales purD GO:0000166,GO:0003674,GO:0003824,GO:0004637,GO:0005488,GO:0005524,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.2.6,6.3.3.1,6.3.4.13,6.3.5.3 ko:K01945,ko:K01952,ko:K11788,ko:K13713 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144,R04208,R04463,R04591 RC00010,RC00064,RC00090,RC00162,RC00166,RC01100,RC01160 ko00000,ko00001,ko00002,ko01000 iECNA114_1301.ECNA114_3417,iECSF_1327.ECSF_3859,iJN746.PP_4823,iPC815.YPO3729,iSB619.SA_RS05245,iYO844.BSU06530 Bacteria 2I2F5@201174,4ERHW@85013,COG0151@1,COG0151@2 NA|NA|NA F Belongs to the GARS family KOPIJCMJ_01336 935866.JAER01000008_gene934 1.5e-178 632.5 Propionibacteriales 2.6.1.55 ko:K15372 ko00410,ko00430,ko01100,map00410,map00430,map01100 R00908,R01684 RC00006,RC00062 ko00000,ko00001,ko01000 Bacteria 2I2F3@201174,4DP1H@85009,COG0160@1,COG0160@2 NA|NA|NA E Aminotransferase class-III KOPIJCMJ_01337 1379270.AUXF01000001_gene2197 3.7e-119 434.9 Gemmatimonadetes namA GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 1.14.13.40,1.6.99.1 ko:K00354,ko:K09461 ko00627,ko01120,map00627,map01120 R00282,R03998,R03999 RC00001,RC00244 ko00000,ko00001,ko01000 Bacteria 1ZTAW@142182,COG1902@1,COG1902@2 NA|NA|NA C NADH:flavin oxidoreductase / NADH oxidase family KOPIJCMJ_01338 1499680.CCFE01000011_gene564 5.5e-69 268.5 Firmicutes Bacteria 1V0SJ@1239,COG5434@1,COG5434@2 NA|NA|NA M Parallel beta-helix repeats KOPIJCMJ_01339 1081644.IMCC13023_01920 2.3e-192 678.3 Microbacteriaceae purA GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 Bacteria 2GMP4@201174,4FKSZ@85023,COG0104@1,COG0104@2 NA|NA|NA F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP KOPIJCMJ_01340 446462.Amir_6917 2.9e-129 468.4 Pseudonocardiales fbaA GO:0003674,GO:0003824,GO:0004332,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016830,GO:0016832,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035375,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 iZ_1308.Z4263 Bacteria 2GM5P@201174,4DZK9@85010,COG0191@1,COG0191@2 NA|NA|NA G fructose-bisphosphate aldolase, class II, yeast E. coli subtype KOPIJCMJ_01341 1121928.AUHE01000001_gene1507 1.1e-75 290.8 Gordoniaceae glcD2 GO:0000166,GO:0003674,GO:0003824,GO:0004457,GO:0004458,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006089,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016053,GO:0016491,GO:0016614,GO:0016898,GO:0019249,GO:0019516,GO:0019752,GO:0022900,GO:0022904,GO:0030447,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046394,GO:0048037,GO:0050660,GO:0050662,GO:0051990,GO:0055114,GO:0071704,GO:0071949,GO:0072330,GO:0097159,GO:0099615,GO:1901265,GO:1901363,GO:1901576,GO:1901615,GO:1901617 1.1.2.4 ko:K00102 ko00620,map00620 R00197 RC00044 ko00000,ko00001,ko01000 Bacteria 2GKI9@201174,4GB5H@85026,COG0277@1,COG0277@2 NA|NA|NA C FAD linked oxidases, C-terminal domain KOPIJCMJ_01342 1041146.ATZB01000055_gene5331 2.5e-31 141.4 Rhizobiaceae eutE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0032787,GO:0042399,GO:0042400,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0046483,GO:0046700,GO:0071704,GO:0072329,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 3.5.1.125 ko:K06987,ko:K15784 ko00260,ko01100,map00260,map01100 R09801 RC00064,RC00300 ko00000,ko00001,ko01000 Bacteria 1MUAA@1224,2TSVB@28211,4B9IA@82115,COG3608@1,COG3608@2 NA|NA|NA S succinylglutamate desuccinylase aspartoacylase KOPIJCMJ_01343 68170.KL590469_gene1813 8.4e-23 113.6 Pseudonocardiales 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2GJP5@201174,4E3JM@85010,COG0377@1,COG0377@2 NA|NA|NA C NADH ubiquinone oxidoreductase, 20 Kd subunit KOPIJCMJ_01346 196162.Noca_2220 8.4e-29 134.0 Propionibacteriales Bacteria 2HIQE@201174,4DWST@85009,COG1261@1,COG1261@2 NA|NA|NA NO SAF KOPIJCMJ_01347 110319.CF8_2348 2.7e-39 169.1 Propionibacteriales Bacteria 2I57A@201174,4DWY4@85009,COG1192@1,COG1192@2 NA|NA|NA D Involved in chromosome partitioning KOPIJCMJ_01348 110319.CF8_2349 3.2e-110 405.6 Propionibacteriales ko:K02283 ko00000,ko02035,ko02044 Bacteria 2GKKJ@201174,4DWY1@85009,COG4962@1,COG4962@2 NA|NA|NA U PFAM type II secretion system protein E KOPIJCMJ_01349 1385519.N801_09660 2.3e-52 212.6 Intrasporangiaceae Bacteria 2GN6E@201174,4FHCH@85021,COG4965@1,COG4965@2 NA|NA|NA U Type II secretion system (T2SS), protein F KOPIJCMJ_01350 397278.JOJN01000013_gene2572 3e-50 205.7 Propionibacteriales ko:K12511 ko00000,ko02044 Bacteria 2HZTC@201174,4DRIG@85009,COG2064@1,COG2064@2 NA|NA|NA NU type II secretion system protein KOPIJCMJ_01352 526225.Gobs_0675 9e-21 106.7 Actinobacteria Bacteria 2I36X@201174,COG4961@1,COG4961@2 NA|NA|NA U overlaps another CDS with the same product name KOPIJCMJ_01354 110319.CF8_1721 3.6e-41 175.6 Propionibacteriales Bacteria 2DVVA@1,2IHH0@201174,32V07@2,4DRC3@85009 NA|NA|NA KOPIJCMJ_01355 196162.Noca_2227 4.5e-15 87.8 Propionibacteriales Bacteria 2GRCJ@201174,4DSH3@85009,COG4961@1,COG4961@2 NA|NA|NA U overlaps another CDS with the same product name KOPIJCMJ_01356 134676.ACPL_5887 3.5e-15 88.2 Micromonosporales Bacteria 2E4ST@1,2GSCH@201174,32ZM5@2,4DEKN@85008 NA|NA|NA S Putative Flp pilus-assembly TadE/G-like KOPIJCMJ_01357 1003195.SCAT_1131 2.3e-83 315.8 Actinobacteria Bacteria 2GJSF@201174,COG0500@1,COG2226@2 NA|NA|NA Q methyltransferase KOPIJCMJ_01358 40571.JOEA01000002_gene4983 2.8e-18 99.8 Pseudonocardiales Bacteria 2B1K4@1,2I2R4@201174,32S9C@2,4E7BQ@85010 NA|NA|NA S Protein of unknown function (DUF3068) KOPIJCMJ_01359 351607.Acel_1088 0.0 1079.3 Frankiales polA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 Bacteria 2GJY2@201174,4ES9K@85013,COG0258@1,COG0258@2,COG0749@1,COG0749@2 NA|NA|NA L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity KOPIJCMJ_01360 1043205.AFYF01000075_gene2080 8.1e-36 156.8 Intrasporangiaceae ydiI Bacteria 2IKTU@201174,4FGPR@85021,COG2050@1,COG2050@2 NA|NA|NA Q protein possibly involved in aromatic compounds catabolism KOPIJCMJ_01361 269800.Tfu_1187 1.5e-66 259.6 Actinobacteria ydfK ko:K07150 ko00000 Bacteria 2GM75@201174,COG1811@1,COG1811@2 NA|NA|NA S Na channel or pump KOPIJCMJ_01362 1306174.JODP01000013_gene7452 2.4e-30 137.9 Actinobacteria ko:K01996 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 2GKSQ@201174,COG0410@1,COG0410@2 NA|NA|NA E ABC transporter KOPIJCMJ_01363 269800.Tfu_2897 2.1e-49 202.6 Streptosporangiales tilS 2.4.2.8,6.3.4.19 ko:K00760,ko:K04075,ko:K15780 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 R00190,R01132,R01229,R02142,R08237,R08238,R08245,R09597 RC00063,RC00122,RC02633,RC02634 ko00000,ko00001,ko01000,ko03016 Bacteria 2GJR4@201174,4EHNI@85012,COG0037@1,COG0037@2 NA|NA|NA D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine KOPIJCMJ_01364 1184607.AUCHE_03_01750 3.2e-74 284.6 Dermatophilaceae hpt 2.4.2.8,6.3.4.19 ko:K00760,ko:K04075,ko:K15780 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 R00190,R01132,R01229,R02142,R08237,R08238,R08245,R09597 RC00063,RC00122,RC02633,RC02634 ko00000,ko00001,ko01000,ko03016 Bacteria 2GMDZ@201174,4F64W@85018,COG0634@1,COG0634@2 NA|NA|NA F Phosphoribosyl transferase domain KOPIJCMJ_01365 262316.MAP_1839 2.3e-11 77.4 Actinobacteria Bacteria 2DU8K@1,2H3ZU@201174,33PD1@2 NA|NA|NA KOPIJCMJ_01366 1463864.JOGO01000077_gene3331 4.9e-36 157.1 Actinobacteria groS GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 ko:K04078 ko00000,ko03029,ko03110 Bacteria 2IHRC@201174,COG0234@1,COG0234@2 NA|NA|NA O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter KOPIJCMJ_01367 1141663.OOC_10266 9.6e-21 107.5 Providencia yjjP GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0008150,GO:0015711,GO:0015740,GO:0015744,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071944 Bacteria 1NH2X@1224,1RN1Q@1236,3Z7GC@586,COG2966@1,COG2966@2 NA|NA|NA S Psort location CytoplasmicMembrane, score KOPIJCMJ_01368 944547.ABLL_0461 1.1e-12 80.1 Epsilonproteobacteria yjjB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006950,GO:0006970,GO:0008150,GO:0009628,GO:0010033,GO:0010243,GO:0015711,GO:0015740,GO:0015744,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0042221,GO:0042493,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071944,GO:1901652,GO:1901698,GO:1901700 Bacteria 1RAWK@1224,2YNRX@29547,42QRH@68525,COG3610@1,COG3610@2 NA|NA|NA S Threonine/Serine exporter, ThrE KOPIJCMJ_01370 391037.Sare_1005 1.1e-59 236.1 Micromonosporales bcp GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016020,GO:0016209,GO:0016491,GO:0016667,GO:0016671,GO:0016684,GO:0032843,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0070887,GO:0071944,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 ko:K03564 ko00000,ko01000 iPC815.YPO3064 Bacteria 2IHZ6@201174,4D9TD@85008,COG1225@1,COG1225@2 NA|NA|NA O alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen KOPIJCMJ_01372 710111.FraQA3DRAFT_5821 2e-42 178.7 Frankiales iscR 2.8.1.7 ko:K04487,ko:K13643 ko00730,ko01100,ko04122,map00730,map01100,map04122 R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03000,ko03016,ko03029 Bacteria 2INF3@201174,4ESZ6@85013,COG1959@1,COG1959@2 NA|NA|NA K transcriptional regulator, Rrf2 family KOPIJCMJ_01376 717774.Marme_3571 6.5e-17 95.1 Bacteria Bacteria COG1357@1,COG1357@2 NA|NA|NA S protein homooligomerization KOPIJCMJ_01377 1454010.JEOE01000008_gene1885 2.6e-154 552.0 Actinobacteria Bacteria 2GK3A@201174,COG1680@1,COG1680@2 NA|NA|NA V Beta-lactamase class C and other penicillin binding proteins KOPIJCMJ_01378 1380354.JIAN01000005_gene2775 5e-108 397.5 Actinobacteria MA20_35565 4.1.3.30 ko:K03417 ko00640,map00640 R00409 RC00286,RC00287 ko00000,ko00001,ko01000 Bacteria 2GMQ4@201174,COG2513@1,COG2513@2 NA|NA|NA G COG2513 PEP phosphonomutase and related enzymes KOPIJCMJ_01379 298655.KI912267_gene6624 7.6e-143 513.8 Frankiales yndJ Bacteria 28KUD@1,2IACK@201174,2ZAB6@2,4EUQM@85013 NA|NA|NA KOPIJCMJ_01380 1172188.KB911820_gene2380 1e-92 346.3 Intrasporangiaceae Bacteria 2GMZV@201174,4FGJN@85021,COG0262@1,COG0262@2 NA|NA|NA H Deaminase reductase KOPIJCMJ_01381 1121952.ATXT01000015_gene306 1.5e-65 256.9 Microbacteriaceae Bacteria 2AU69@1,2IFP7@201174,31JT7@2,4FRYV@85023 NA|NA|NA KOPIJCMJ_01383 926564.KI911673_gene6308 7.5e-30 137.5 Actinobacteria Bacteria 2HRC6@201174,COG1280@1,COG1280@2 NA|NA|NA E Sap, sulfolipid-1-addressing protein KOPIJCMJ_01385 367299.JOEE01000002_gene2522 2.1e-187 661.8 Intrasporangiaceae Bacteria 2GWBV@201174,4FE3R@85021,COG1672@1,COG1672@2 NA|NA|NA S AAA ATPase domain KOPIJCMJ_01386 1032480.MLP_35440 4.3e-56 224.2 Propionibacteriales Bacteria 2ISME@201174,4DV13@85009,COG4767@1,COG4767@2 NA|NA|NA V VanZ like family KOPIJCMJ_01387 1048339.KB913029_gene4006 9.3e-89 333.2 Frankiales rpe GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJZ9@201174,4ERMA@85013,COG0036@1,COG0036@2 NA|NA|NA G Belongs to the ribulose-phosphate 3-epimerase family KOPIJCMJ_01388 2045.KR76_14595 4e-110 405.2 Propionibacteriales sun GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.176,5.3.1.9 ko:K01810,ko:K03500 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko03009,ko04147 Bacteria 2GM21@201174,4DP4E@85009,COG0144@1,COG0144@2,COG0781@1,COG0781@2 NA|NA|NA JK Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family KOPIJCMJ_01389 1449353.JQMQ01000005_gene829 2e-121 442.2 Streptacidiphilus fmt GO:0003674,GO:0003824,GO:0004479,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006418,GO:0006431,GO:0006464,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019752,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.1.176,2.1.2.9 ko:K00604,ko:K03500 ko00670,ko00970,map00670,map00970 R03940 RC00026,RC00165 ko00000,ko00001,ko01000,ko03009 iECABU_c1320.ECABU_c37050,iECUMN_1333.ECUMN_3761,ic_1306.c4048 Bacteria 2GKH5@201174,2NH3A@228398,COG0223@1,COG0223@2 NA|NA|NA J Formyl transferase, C-terminal domain KOPIJCMJ_01390 1121017.AUFG01000004_gene3201 7.9e-70 270.0 Intrasporangiaceae def 3.5.1.88 ko:K01462 ko00000,ko01000 Bacteria 2GJ87@201174,4FG5A@85021,COG0242@1,COG0242@2 NA|NA|NA J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions KOPIJCMJ_01391 263358.VAB18032_15045 4.5e-134 485.3 Micromonosporales priA GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 ko:K04066 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 2GKES@201174,4DA4R@85008,COG1198@1,COG1198@2 NA|NA|NA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA KOPIJCMJ_01392 266940.Krad_2989 8.3e-79 300.1 Actinobacteria metK GO:0003674,GO:0003824,GO:0004478,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0016740,GO:0016765,GO:0019899,GO:0030312,GO:0035375,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ4U@201174,COG0192@1,COG0192@2 NA|NA|NA H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme KOPIJCMJ_01394 455632.SGR_1572 1.1e-20 105.5 Streptomyces griseus group argF GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0033554,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 iAF1260.b0273,iECDH10B_1368.ECDH10B_0261,iECS88_1305.ECS88_4841,iHN637.CLJU_RS12430,iJO1366.b0273,iJR904.b0273,iY75_1357.Y75_RS01410 Bacteria 2GJ6H@201174,419CU@629295,COG0078@1,COG0078@2 NA|NA|NA E Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain KOPIJCMJ_01395 1306174.JODP01000018_gene4493 2.2e-23 115.2 Actinobacteria wblB ko:K18955 ko00000,ko03000 Bacteria 2CC1Y@1,2IQS5@201174,32S23@2 NA|NA|NA K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA KOPIJCMJ_01396 223184.AS25_09540 2.1e-26 124.8 Micrococcaceae Bacteria 1W9TC@1268,2CAFG@1,2IQ98@201174,32RRB@2 NA|NA|NA S Protein of unknown function (DUF3039) KOPIJCMJ_01397 1463920.JOGB01000039_gene946 1.4e-14 85.5 Actinobacteria prmC 2.1.1.297 ko:K02493 R10806 RC00003,RC03279 ko00000,ko01000,ko03012 Bacteria 2GNC1@201174,COG2890@1,COG2890@2 NA|NA|NA J Belongs to the protein N5-glutamine methyltransferase family KOPIJCMJ_01398 1538295.JY96_04010 5.9e-42 176.8 unclassified Burkholderiales hrp1 Bacteria 1KKNW@119065,1N0H3@1224,2VQEB@28216,COG0517@1,COG0517@2 NA|NA|NA S CBS domain KOPIJCMJ_01400 1122611.KB903963_gene4836 1.1e-122 446.4 Streptosporangiales Bacteria 2GMHR@201174,4EGEB@85012,COG0604@1,COG0604@2 NA|NA|NA C Zinc-binding dehydrogenase KOPIJCMJ_01401 1123320.KB889698_gene9326 7.5e-99 367.1 Actinobacteria hbd 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 Bacteria 2GJBM@201174,COG1250@1,COG1250@2 NA|NA|NA I 3-hydroxyacyl-CoA dehydrogenase KOPIJCMJ_01402 1146883.BLASA_3913 5.2e-160 570.9 Frankiales murA GO:0008150,GO:0040007 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 R00660 RC00350 ko00000,ko00001,ko01000,ko01011 Bacteria 2GJPW@201174,4ERJ6@85013,COG0766@1,COG0766@2 NA|NA|NA M Belongs to the EPSP synthase family. MurA subfamily KOPIJCMJ_01403 585531.HMPREF0063_12237 1.1e-66 259.6 Propionibacteriales yvqK 2.5.1.17 ko:K00798 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 Bacteria 2GMHN@201174,4DNZ5@85009,COG2096@1,COG2096@2 NA|NA|NA S Cobalamin adenosyltransferase KOPIJCMJ_01404 1268303.RHODMAR_0120 1e-75 290.4 Nocardiaceae Bacteria 2GP1D@201174,4G9DV@85025,COG1215@1,COG1215@2 NA|NA|NA M Glycosyltransferase like family 2 KOPIJCMJ_01405 543632.JOJL01000008_gene5609 9.1e-85 320.5 Micromonosporales exoM Bacteria 2GKTW@201174,4DIHT@85008,COG1216@1,COG1216@2 NA|NA|NA S Glycosyltransferase like family 2 KOPIJCMJ_01406 1283287.KB822576_gene3718 3.2e-39 168.3 Propionibacteriales rpsA GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 ko:K02945 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GJAK@201174,4DPIM@85009,COG0539@1,COG0539@2 NA|NA|NA J ribosomal protein KOPIJCMJ_01407 479435.Kfla_3091 4.2e-32 146.0 Propionibacteriales ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GJV2@201174,4DQVU@85009,COG2244@1,COG2244@2 NA|NA|NA S polysaccharide biosynthetic process KOPIJCMJ_01408 1111729.ATYV01000023_gene1471 6.3e-50 204.1 Corynebacteriaceae coaE GO:0005575,GO:0005622,GO:0005623,GO:0009579,GO:0016020,GO:0034357,GO:0042651,GO:0044424,GO:0044436,GO:0044464 2.7.1.24 ko:K00859,ko:K02096,ko:K02286,ko:K02290,ko:K02630,ko:K05378,ko:K05379,ko:K05380 ko00196,ko00770,ko01100,map00196,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko00194,ko01000 Bacteria 22MZB@1653,2GN96@201174,COG0237@1,COG0237@2 NA|NA|NA F Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A KOPIJCMJ_01409 926550.CLDAP_11630 1.1e-09 69.7 Bacteria 3.1.3.3 ko:K07315 ko00000,ko01000,ko03021 Bacteria COG2452@1,COG2452@2,COG4936@1,COG4936@2 NA|NA|NA KT Sensory domain found in PocR KOPIJCMJ_01410 1304865.JAGF01000001_gene3099 1.5e-172 612.5 Actinobacteria 1.8.5.4 ko:K17218 ko00920,map00920 R10152 RC03155 ko00000,ko00001,ko01000 Bacteria 2GRTN@201174,COG0446@1,COG0446@2 NA|NA|NA P pyridine nucleotide-disulphide oxidoreductase KOPIJCMJ_01411 926550.CLDAP_11610 8e-25 120.9 Bacteria Bacteria COG2427@1,COG2427@2 NA|NA|NA S Protein of unknown function (DUF1641) KOPIJCMJ_01412 1043493.BBLU01000020_gene1080 4.9e-32 143.7 Actinobacteria dsrC 1.8.5.4 ko:K11179,ko:K17218 ko00920,ko04122,map00920,map04122 R10152 RC03155 ko00000,ko00001,ko01000,ko03016 Bacteria 2IQB2@201174,COG2920@1,COG2920@2 NA|NA|NA P PFAM DsrC family protein KOPIJCMJ_01413 369723.Strop_1612 8.7e-58 229.9 Micromonosporales perX Bacteria 2IFXH@201174,4DIG7@85008,COG2210@1,COG2210@2 NA|NA|NA S DsrE/DsrF/DrsH-like family KOPIJCMJ_01414 1144275.COCOR_03122 6.6e-25 120.2 Proteobacteria Bacteria 1NKMZ@1224,COG3832@1,COG3832@2,COG5646@1,COG5646@2 NA|NA|NA S Domain of unknown function (DU1801) KOPIJCMJ_01415 679197.HMPREF9336_04200 4.8e-58 232.3 Actinobacteria Bacteria 2GN56@201174,COG1835@1,COG1835@2 NA|NA|NA I Acyltransferase KOPIJCMJ_01416 479435.Kfla_5620 2.4e-11 76.3 Propionibacteriales Bacteria 2B5R0@1,2IPMA@201174,31YKI@2,4DR93@85009 NA|NA|NA KOPIJCMJ_01417 1120954.ATXE01000001_gene2216 3.3e-20 104.8 Propionibacteriales Bacteria 2IT3M@201174,4DVDP@85009,COG3877@1,COG3877@2 NA|NA|NA S Protein of unknown function (DUF2089) KOPIJCMJ_01418 477641.MODMU_4177 8.4e-106 390.2 Frankiales 1.13.11.8 ko:K04100,ko:K15777 ko00362,ko00624,ko00627,ko00965,ko01120,map00362,map00624,map00627,map00965,map01120 R01632,R03550,R04280,R08836,R09565 RC00233,RC00387,RC00535,RC02567,RC02694 br01602,ko00000,ko00001,ko01000 Bacteria 2GKTV@201174,4ESG8@85013,COG3384@1,COG3384@2 NA|NA|NA S Extradiol ring-cleavage dioxygenase class III protein subunit B KOPIJCMJ_01419 1240349.ANGC01000010_gene2821 1.8e-92 346.7 Nocardiaceae 2.3.1.20 ko:K00635 ko00561,ko01100,map00561,map01100 M00089 R02251 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 Bacteria 2IGNH@201174,4G6IZ@85025,COG1020@1,COG1020@2 NA|NA|NA I Protein of unknown function (DUF1298) KOPIJCMJ_01420 479435.Kfla_0631 2.2e-30 139.0 Propionibacteriales lytE ko:K21471 ko00000,ko01000,ko01002,ko01011 Bacteria 2IFNI@201174,4DS9B@85009,COG0791@1,COG0791@2,COG3409@1,COG3409@2 NA|NA|NA M NlpC/P60 family KOPIJCMJ_01421 1463820.JOGW01000004_gene4608 3.4e-21 107.5 Actinobacteria ko:K21600 ko00000,ko03000 Bacteria 2IQ7U@201174,COG1937@1,COG1937@2 NA|NA|NA S protein conserved in bacteria KOPIJCMJ_01422 1206101.AZXC01000007_gene2475 3.7e-64 251.5 Actinobacteria ideR ko:K03709 ko00000,ko03000 Bacteria 2GKMC@201174,COG1321@1,COG1321@2 NA|NA|NA K iron dependent repressor KOPIJCMJ_01423 1123320.KB889746_gene8006 2.4e-136 492.3 Actinobacteria phrB GO:0000003,GO:0000166,GO:0000719,GO:0001101,GO:0002252,GO:0002376,GO:0003006,GO:0003674,GO:0003824,GO:0003904,GO:0003913,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005773,GO:0006139,GO:0006259,GO:0006281,GO:0006290,GO:0006325,GO:0006338,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006873,GO:0006874,GO:0006875,GO:0006950,GO:0006952,GO:0006974,GO:0006996,GO:0007154,GO:0007165,GO:0007275,GO:0007623,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009314,GO:0009414,GO:0009415,GO:0009416,GO:0009605,GO:0009606,GO:0009607,GO:0009615,GO:0009628,GO:0009637,GO:0009638,GO:0009642,GO:0009645,GO:0009646,GO:0009648,GO:0009719,GO:0009725,GO:0009785,GO:0009791,GO:0009881,GO:0009882,GO:0009888,GO:0009893,GO:0009909,GO:0009911,GO:0009987,GO:0010033,GO:0010035,GO:0010073,GO:0010075,GO:0010118,GO:0010228,GO:0010244,GO:0010617,GO:0014070,GO:0016043,GO:0016604,GO:0016829,GO:0016830,GO:0017076,GO:0018298,GO:0019222,GO:0019538,GO:0019637,GO:0019725,GO:0022414,GO:0022603,GO:0023052,GO:0030003,GO:0030522,GO:0030554,GO:0031323,GO:0031325,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0033993,GO:0034641,GO:0035639,GO:0036094,GO:0036211,GO:0038023,GO:0040008,GO:0042221,GO:0042592,GO:0042726,GO:0042752,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0048037,GO:0048507,GO:0048509,GO:0048511,GO:0048518,GO:0048522,GO:0048571,GO:0048573,GO:0048574,GO:0048580,GO:0048582,GO:0048583,GO:0048608,GO:0048638,GO:0048731,GO:0048831,GO:0048856,GO:0048878,GO:0050660,GO:0050662,GO:0050789,GO:0050793,GO:0050794,GO:0050801,GO:0050896,GO:0051094,GO:0051186,GO:0051239,GO:0051240,GO:0051276,GO:0051480,GO:0051607,GO:0051704,GO:0051707,GO:0051716,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0055086,GO:0060089,GO:0061458,GO:0065007,GO:0065008,GO:0070013,GO:0071214,GO:0071478,GO:0071482,GO:0071483,GO:0071704,GO:0071840,GO:0071949,GO:0072387,GO:0072503,GO:0072507,GO:0090304,GO:0097159,GO:0097367,GO:0098542,GO:0098771,GO:0104004,GO:0140097,GO:1900618,GO:1901265,GO:1901360,GO:1901363,GO:1901371,GO:1901564,GO:1901700,GO:1902347,GO:1905421,GO:2000024,GO:2000026,GO:2000028,GO:2000241,GO:2000243,GO:2000377,GO:2000379 4.1.99.3 ko:K01669 ko00000,ko01000,ko03400 Bacteria 2GJXU@201174,COG0415@1,COG0415@2 NA|NA|NA L Belongs to the DNA photolyase family KOPIJCMJ_01424 1068980.ARVW01000001_gene8375 1.6e-52 213.0 Pseudonocardiales parA ko:K03496 ko00000,ko03036,ko04812 Bacteria 2H4UC@201174,4DZB6@85010,COG1192@1,COG1192@2 NA|NA|NA D involved in chromosome partitioning KOPIJCMJ_01427 287986.DV20_43550 2.9e-147 528.1 Pseudonocardiales Bacteria 2H0AR@201174,4E90A@85010,COG0627@1,COG0627@2 NA|NA|NA S Putative esterase KOPIJCMJ_01428 543632.JOJL01000027_gene2595 1.1e-39 171.0 Micromonosporales ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2I9MY@201174,4DCFI@85008,COG1668@1,COG1668@2 NA|NA|NA CP ABC-2 family transporter protein KOPIJCMJ_01429 469383.Cwoe_0732 5.3e-74 284.6 Actinobacteria ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2I2DK@201174,COG4152@1,COG4152@2 NA|NA|NA S ABC transporter KOPIJCMJ_01430 765420.OSCT_1250 1.3e-21 110.2 Chloroflexia ko:K08981 ko00000 Bacteria 2G70V@200795,375QN@32061,COG3428@1,COG3428@2 NA|NA|NA S PFAM membrane-flanked domain KOPIJCMJ_01431 1449347.JQLN01000005_gene4049 3.1e-55 221.9 Kitasatospora pdxH 1.4.3.5 ko:K00275 ko00750,ko01100,ko01120,map00750,map01100,map01120 M00124 R00277,R00278,R01710,R01711 RC00048,RC00116 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJCR@201174,2M25F@2063,COG0259@1,COG0259@2 NA|NA|NA H Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) KOPIJCMJ_01432 285535.JOEY01000002_gene4814 9.4e-174 616.3 Actinobacteria citA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GKST@201174,COG0372@1,COG0372@2 NA|NA|NA C Belongs to the citrate synthase family KOPIJCMJ_01433 644283.Micau_0514 8.6e-151 540.0 Micromonosporales serC GO:0001505,GO:0003674,GO:0003824,GO:0004760,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005886,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006807,GO:0008150,GO:0008152,GO:0008453,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019265,GO:0019752,GO:0040007,GO:0042133,GO:0042136,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0065007,GO:0065008,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 2GKYK@201174,4D8WE@85008,COG1932@1,COG1932@2 NA|NA|NA EH Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine KOPIJCMJ_01434 1150864.MILUP08_42574 8.6e-43 179.9 Micromonosporales Bacteria 2HR7I@201174,4DFE0@85008,COG2315@1,COG2315@2 NA|NA|NA S YjbR KOPIJCMJ_01435 1123320.KB889723_gene7524 2.9e-46 192.6 Actinobacteria Bacteria 2GNAZ@201174,COG3386@1,COG3386@2 NA|NA|NA G PFAM SMP-30 Gluconolaconase KOPIJCMJ_01436 656024.FsymDg_0268 4.8e-07 60.5 Frankiales Bacteria 2ETMT@1,2HU3T@201174,33M5J@2,4EWV2@85013 NA|NA|NA S Protein of unknown function (DUF2530) KOPIJCMJ_01437 1048339.KB913029_gene2148 2.2e-62 245.7 Frankiales Bacteria 28NWB@1,2GJ74@201174,2ZBU7@2,4ESJV@85013 NA|NA|NA S Protein of unknown function (DUF3027) KOPIJCMJ_01438 1206101.AZXC01000007_gene2428 6.7e-09 67.4 Actinobacteria Bacteria 2F261@1,2IFIE@201174,33V4D@2 NA|NA|NA KOPIJCMJ_01439 743718.Isova_2592 7.1e-41 173.3 Promicromonosporaceae cspB ko:K03704 ko00000,ko03000 Bacteria 2IKXN@201174,4F4QM@85017,COG1278@1,COG1278@2 NA|NA|NA K Cold shock protein domain KOPIJCMJ_01441 1003195.SCAT_2429 5.2e-107 395.6 Actinobacteria M1-1077 Bacteria 2GURQ@201174,COG2378@1,COG2378@2 NA|NA|NA K Helicase conserved C-terminal domain KOPIJCMJ_01442 471852.Tcur_0810 9.6e-252 875.9 Streptosporangiales ercc3 3.6.4.12 ko:K10843 ko03022,ko03420,map03022,map03420 M00290 ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 Bacteria 2GIR9@201174,4EHX6@85012,COG1061@1,COG1061@2 NA|NA|NA L ERCC3/RAD25/XPB C-terminal helicase KOPIJCMJ_01443 477641.MODMU_4618 3.3e-47 194.9 Frankiales bar 2.3.1.183 ko:K03823 ko00440,ko01130,map00440,map01130 R08871,R08938 RC00004,RC00064 ko00000,ko00001,ko01000 Bacteria 2IHSY@201174,4EVJN@85013,COG1247@1,COG1247@2 NA|NA|NA M Acetyltransferase (GNAT) domain KOPIJCMJ_01446 1077972.ARGLB_083_00470 7.1e-33 149.8 Actinobacteria Bacteria 2EIJM@1,2IREQ@201174,33CAY@2 NA|NA|NA KOPIJCMJ_01447 103733.JNYO01000031_gene1513 9e-64 250.0 Pseudonocardiales gltB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 Bacteria 2GN09@201174,4DX9H@85010,COG0067@1,COG0067@2,COG0069@1,COG0069@2,COG0070@1,COG0070@2 NA|NA|NA E glutamate synthase KOPIJCMJ_01448 405948.SACE_3997 2.3e-209 734.9 Pseudonocardiales gltD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 iJN678.gltD,iNJ661.Rv3858c,iSB619.SA_RS02450 Bacteria 2GJ0A@201174,4DYTC@85010,COG0493@1,COG0493@2 NA|NA|NA E NADH NADPH, small subunit KOPIJCMJ_01449 134676.ACPL_3028 1.7e-104 386.3 Micromonosporales ftsH2 ko:K03798,ko:K13525 ko04141,ko05134,map04141,map05134 M00400,M00403,M00742 ko00000,ko00001,ko00002,ko01000,ko01002,ko03019,ko03110,ko04131,ko04147 3.A.16.1 Bacteria 2I2U8@201174,4DBYF@85008,COG0465@1,COG0465@2 NA|NA|NA O Holliday junction DNA helicase ruvB N-terminus KOPIJCMJ_01451 67315.JOBD01000013_gene7146 2.5e-166 592.0 Actinobacteria pyk GO:0003674,GO:0003824,GO:0004743,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016043,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042802,GO:0042866,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 e_coli_core.b1854,iAF1260.b1854,iB21_1397.B21_01813,iBWG_1329.BWG_1668,iEC042_1314.EC042_2021,iECBD_1354.ECBD_1784,iECB_1328.ECB_01825,iECDH10B_1368.ECDH10B_1995,iECDH1ME8569_1439.ECDH1ME8569_1801,iECD_1391.ECD_01825,iECO103_1326.ECO103_2044,iECO111_1330.ECO111_2362,iECO26_1355.ECO26_2692,iECUMN_1333.ECUMN_2152,iETEC_1333.ETEC_1887,iEcDH1_1363.EcDH1_1786,iEcE24377_1341.EcE24377A_2084,iEcHS_1320.EcHS_A1947,iEcSMS35_1347.EcSMS35_1332,iEcolC_1368.EcolC_1778,iG2583_1286.G2583_2306,iJO1366.b1854,iJR904.b1854,iSBO_1134.SBO_1162,iSSON_1240.SSON_1294,iSbBS512_1146.SbBS512_E2130,iUMNK88_1353.UMNK88_2326,iY75_1357.Y75_RS09740 Bacteria 2GJY8@201174,COG0469@1,COG0469@2 NA|NA|NA G Belongs to the pyruvate kinase family KOPIJCMJ_01452 1449353.JQMQ01000005_gene847 8.2e-66 256.5 Streptacidiphilus bldD ko:K07110,ko:K21572 ko00000,ko02000,ko03000 8.A.46.1,8.A.46.3 Bacteria 2GVFR@201174,2NEHZ@228398,COG1395@1,COG1395@2 NA|NA|NA K Helix-turn-helix KOPIJCMJ_01453 1123320.KB889665_gene1430 7.1e-63 246.9 Actinobacteria pyrR GO:0003674,GO:0003700,GO:0003824,GO:0004845,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006220,GO:0006221,GO:0006355,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0031323,GO:0031326,GO:0034641,GO:0034654,GO:0043094,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046390,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0055086,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0080090,GO:0090407,GO:0140110,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141 2.4.2.9 ko:K02825 ko00240,ko01100,map00240,map01100 R00966 RC00063 ko00000,ko00001,ko01000,ko03000 iHN637.CLJU_RS05275 Bacteria 2GJNP@201174,COG2065@1,COG2065@2 NA|NA|NA F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant KOPIJCMJ_01454 1123320.KB889665_gene1431 3.1e-138 498.0 Actinobacteria pyrB GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 ko:K00608,ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 iYO844.BSU15490 Bacteria 2GKNA@201174,COG0540@1,COG0540@2 NA|NA|NA F Belongs to the ATCase OTCase family KOPIJCMJ_01455 33876.JNXY01000010_gene2613 9.7e-91 340.5 Micromonosporales ssuA ko:K02051 M00188 ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 iAF987.Gmet_0996 Bacteria 2GK7X@201174,4DBAN@85008,COG0715@1,COG0715@2 NA|NA|NA P ABC transporter, phosphonate, periplasmic substrate-binding protein KOPIJCMJ_01456 1206730.BAGA01000093_gene452 3.1e-22 111.3 Nocardiaceae Bacteria 2E7YB@1,2IRTP@201174,332CR@2,4G2XR@85025 NA|NA|NA KOPIJCMJ_01457 1048339.KB913029_gene3874 6.8e-90 337.8 Frankiales trmA GO:0000049,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016740,GO:0016741,GO:0019843,GO:0030488,GO:0030696,GO:0030697,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363 2.1.1.190,2.1.1.35 ko:K00557,ko:K03215 ko00000,ko01000,ko03009,ko03016 Bacteria 2GIR3@201174,4ERZK@85013,COG2265@1,COG2265@2 NA|NA|NA J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family KOPIJCMJ_01458 479432.Sros_6758 3.6e-227 794.7 Streptosporangiales Bacteria 2GK5V@201174,4EH63@85012,COG0531@1,COG0531@2 NA|NA|NA E Amino acid permease KOPIJCMJ_01459 1133850.SHJG_6974 8.1e-77 293.5 Actinobacteria ceoB ko:K03499 ko00000,ko02000 2.A.38.1,2.A.38.4 Bacteria 2GK4N@201174,COG0569@1,COG0569@2 NA|NA|NA P PFAM TrkA-N domain protein KOPIJCMJ_01460 1122611.KB903954_gene5626 4.9e-82 310.8 Streptosporangiales trkA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03499 ko00000,ko02000 2.A.38.1,2.A.38.4 Bacteria 2GKB9@201174,4EGQI@85012,COG0569@1,COG0569@2 NA|NA|NA P TrkA-N domain KOPIJCMJ_01461 1120950.KB892748_gene3215 2e-46 192.6 Propionibacteriales Bacteria 2AVV0@1,2GJKP@201174,31MNQ@2,4DQXN@85009 NA|NA|NA S Protein of unknown function (DUF3159) KOPIJCMJ_01462 1048339.KB913029_gene3870 5.3e-31 140.6 Frankiales 3.6.4.12 ko:K03655 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 2IHRX@201174,4ETC1@85013,COG1200@1,COG1200@2 NA|NA|NA KL Nucleic acid binding, OB-fold, tRNA KOPIJCMJ_01463 593907.Celgi_1460 1.3e-49 203.4 Cellulomonadaceae Bacteria 28J4D@1,2I2E9@201174,30NZ9@2,4F14W@85016 NA|NA|NA S Protein of unknown function (DUF3710) KOPIJCMJ_01464 1348663.KCH_54620 4.7e-60 237.3 Kitasatospora dut GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23,4.1.1.36,6.3.2.5 ko:K01520,ko:K13038 ko00240,ko00770,ko00983,ko01100,map00240,map00770,map00983,map01100 M00053,M00120 R02100,R03269,R04231,R11896 RC00002,RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000,ko03400 Bacteria 2IHYY@201174,2M2SY@2063,COG0756@1,COG0756@2 NA|NA|NA F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA KOPIJCMJ_01465 68260.JOAY01000013_gene2772 2.3e-51 208.8 Actinobacteria Bacteria 2GKY1@201174,COG2050@1,COG2050@2 NA|NA|NA Q PFAM thioesterase superfamily KOPIJCMJ_01466 935839.JAGJ01000003_gene1380 4.7e-18 97.8 Promicromonosporaceae Bacteria 2E4C2@1,2IFS5@201174,32Z7M@2,4F4VX@85017 NA|NA|NA S Protein of unknown function (DUF3093) KOPIJCMJ_01468 1184609.KILIM_083_00160 3.4e-38 164.1 Dermatophilaceae Bacteria 2ATJW@1,2IKN0@201174,31J3Z@2,4F70K@85018 NA|NA|NA S Domain of unknown function (DUF4193) KOPIJCMJ_01469 710111.FraQA3DRAFT_2974 1.6e-43 182.6 Frankiales Bacteria 2GP22@201174,4EVCG@85013,COG0663@1,COG0663@2 NA|NA|NA S Bacterial transferase hexapeptide (six repeats) KOPIJCMJ_01470 1348663.KCH_54540 2.2e-66 259.2 Kitasatospora suhB 3.1.3.25,4.99.1.1,4.99.1.9 ko:K01092,ko:K01772 ko00521,ko00562,ko00860,ko01100,ko01110,ko04070,map00521,map00562,map00860,map01100,map01110,map04070 M00121,M00131 R00310,R01185,R01186,R01187,R11329 RC00078,RC01012 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJQE@201174,2M1IQ@2063,COG0483@1,COG0483@2 NA|NA|NA G Inositol monophosphatase family KOPIJCMJ_01471 68223.JNZY01000006_gene4113 3.7e-100 371.7 Actinobacteria hemH GO:0003674,GO:0003824,GO:0004325,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0046148,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051540,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJTQ@201174,COG0276@1,COG0276@2 NA|NA|NA H Catalyzes the ferrous insertion into protoporphyrin IX KOPIJCMJ_01472 590998.Celf_2152 3.5e-49 202.6 Cellulomonadaceae GO:0008150,GO:0040007 Bacteria 28PUQ@1,2GNQM@201174,2ZCFK@2,4F1CN@85016 NA|NA|NA S Protein of unknown function (DUF3071) KOPIJCMJ_01473 477641.MODMU_3477 4.9e-74 285.0 Frankiales Bacteria 2GISU@201174,4ESFM@85013,COG1524@1,COG1524@2 NA|NA|NA S PFAM type I phosphodiesterase nucleotide pyrophosphatase KOPIJCMJ_01474 1120950.KB892748_gene3185 8.5e-54 216.9 Propionibacteriales Bacteria 29850@1,2GKR1@201174,2ZVAX@2,4DQC6@85009 NA|NA|NA KOPIJCMJ_01475 1123320.KB889707_gene7976 8e-235 820.5 Actinobacteria iAF987.Gmet_2142 Bacteria 2GKN1@201174,COG0454@1,COG0456@2,COG1042@1,COG1042@2 NA|NA|NA C CoA-binding domain protein KOPIJCMJ_01476 446466.Cfla_1693 5.4e-291 1006.9 Cellulomonadaceae gyrA GO:0005575,GO:0005622,GO:0005623,GO:0009330,GO:0032991,GO:0044424,GO:0044464 5.99.1.3 ko:K02469,ko:K02621 ko00000,ko01000,ko02048,ko03032,ko03036,ko03400 Bacteria 2GJ2Q@201174,4F1NX@85016,COG0188@1,COG0188@2 NA|NA|NA L SMART DNA gyrase topoisomerase IV subunit A KOPIJCMJ_01477 28042.GU90_11695 1.8e-31 143.3 Pseudonocardiales Bacteria 2GRSQ@201174,4DYIC@85010,COG4759@1,COG4759@2 NA|NA|NA O Sucrase/ferredoxin-like KOPIJCMJ_01478 1211815.CBYP010000069_gene1350 2e-23 115.9 Frankiales Bacteria 2GMEH@201174,4EUCD@85013,COG1028@1,COG1028@2 NA|NA|NA IQ KR domain KOPIJCMJ_01479 1449065.JMLL01000017_gene3865 3.7e-15 87.8 Bacteria ko:K14987 ko02020,map02020 M00524 ko00000,ko00001,ko00002,ko02022 Bacteria COG4566@1,COG4566@2 NA|NA|NA T phosphorelay signal transduction system KOPIJCMJ_01480 1123072.AUDH01000032_gene78 6.2e-86 324.3 Rhodospirillales ko:K07481 ko00000 Bacteria 1MVDK@1224,2JQR2@204441,2TS7B@28211,COG3039@1,COG3039@2 NA|NA|NA L Transposase KOPIJCMJ_01481 195105.CN97_14935 1.4e-133 482.6 Alphaproteobacteria 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 Bacteria 1MWV5@1224,2TRE1@28211,COG0329@1,COG0329@2 NA|NA|NA EM Belongs to the DapA family KOPIJCMJ_01482 195105.CN97_14930 1.1e-103 382.9 Alphaproteobacteria Bacteria 1MUWV@1224,2TU1X@28211,COG0684@1,COG0684@2 NA|NA|NA H Methyltransferase KOPIJCMJ_01483 68223.JNZY01000015_gene2340 3e-07 61.2 Actinobacteria Bacteria 2GKG1@201174,COG0558@1,COG0558@2 NA|NA|NA I Belongs to the CDP-alcohol phosphatidyltransferase class-I family KOPIJCMJ_01484 1348338.ADILRU_1958 4.6e-74 284.6 Microbacteriaceae Bacteria 2GN3C@201174,4FKEI@85023,COG0558@1,COG0558@2 NA|NA|NA I CDP-alcohol phosphatidyltransferase KOPIJCMJ_01485 1120959.ATXF01000010_gene75 5.4e-100 370.9 Microbacteriaceae GO:0003674,GO:0003824,GO:0016740,GO:0016757 ko:K07011 ko00000 Bacteria 2GK2D@201174,4FMHT@85023,COG1216@1,COG1216@2 NA|NA|NA S Glycosyl transferase family 2 KOPIJCMJ_01486 935839.JAGJ01000002_gene821 2e-78 298.9 Actinobacteria phnW 2.6.1.37,2.7.7.74,2.7.8.12 ko:K03430,ko:K07281,ko:K09809 ko00440,ko00562,ko01100,ko01120,map00440,map00562,map01100,map01120 R04152,R09669 RC00002,RC00008,RC00062 ko00000,ko00001,ko01000,ko01007 Bacteria 2GN1Y@201174,COG1213@1,COG1213@2 NA|NA|NA M transferase KOPIJCMJ_01487 909613.UO65_5851 4.1e-96 358.6 Actinobacteria Bacteria 2H6EP@201174,COG1887@1,COG1887@2 NA|NA|NA M Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC KOPIJCMJ_01488 110663.KI911558_gene1353 6.7e-10 70.9 Synechococcus ste14 Bacteria 1G67D@1117,1H0KJ@1129,COG2020@1,COG2020@2 NA|NA|NA O Isoprenylcysteine carboxyl methyltransferase (ICMT) family KOPIJCMJ_01489 1996.JOFO01000004_gene3448 3.3e-91 341.3 Streptosporangiales scoB 2.8.3.5 ko:K01029 ko00072,ko00280,ko00650,map00072,map00280,map00650 R00410 RC00014 ko00000,ko00001,ko01000 Bacteria 2GKV9@201174,4EI8M@85012,COG2057@1,COG2057@2 NA|NA|NA I Coenzyme A transferase KOPIJCMJ_01490 1348663.KCH_29210 1.2e-98 366.3 Kitasatospora 2.8.3.5 ko:K01028 ko00072,ko00280,ko00650,map00072,map00280,map00650 R00410 RC00014 ko00000,ko00001,ko01000 Bacteria 2GK61@201174,2M482@2063,COG1788@1,COG1788@2 NA|NA|NA I Coenzyme A transferase KOPIJCMJ_01491 266940.Krad_0030 9.5e-75 287.7 Actinobacteria Bacteria 2GJM3@201174,COG1316@1,COG1316@2 NA|NA|NA K cell envelope-related transcriptional attenuator KOPIJCMJ_01492 1306174.JODP01000001_gene4657 9.3e-61 242.3 Actinobacteria Bacteria 2GNDB@201174,COG4102@1,COG4102@2,COG5479@1,COG5479@2 NA|NA|NA M N-acetylmuramoyl-L-alanine amidase KOPIJCMJ_01493 1463857.JOFZ01000018_gene1431 1.8e-18 99.8 Actinobacteria Bacteria 2GIX4@201174,COG0318@1,COG0318@2 NA|NA|NA IQ COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases KOPIJCMJ_01494 1079986.JH164840_gene4710 2e-117 429.1 Actinobacteria manC 2.7.7.13,5.4.2.8 ko:K00966,ko:K16881 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114,M00361,M00362 R00885,R01818 RC00002,RC00408 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKTE@201174,COG1208@1,COG1208@2 NA|NA|NA JM Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B gamma epsilon subunits KOPIJCMJ_01495 1449355.JQNR01000005_gene2189 2.2e-67 262.7 Actinobacteria 3.2.2.21 ko:K01247 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 2GP69@201174,COG0122@1,COG0122@2 NA|NA|NA L 3-methyladenine DNA glycosylase KOPIJCMJ_01497 1122622.ATWJ01000015_gene620 4e-32 143.7 Intrasporangiaceae whiB2 ko:K18955 ko00000,ko03000 Bacteria 2CC1Y@1,2IQ4Q@201174,32RUK@2,4FHAS@85021 NA|NA|NA K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA KOPIJCMJ_01498 1463864.JOGO01000058_gene3814 7.7e-90 339.0 Actinobacteria Bacteria 2GIUN@201174,COG1216@1,COG1216@2 NA|NA|NA M PFAM Glycosyl transferase family 2 KOPIJCMJ_01499 1120950.KB892759_gene6287 2.2e-32 147.1 Propionibacteriales dedD ko:K02520,ko:K03749,ko:K06204,ko:K16291 ko02026,map02026 ko00000,ko00001,ko01002,ko01011,ko03000,ko03009,ko03012,ko03021,ko03029 Bacteria 2HC8A@201174,4DRQT@85009,COG3147@1,COG3147@2 NA|NA|NA S Non-essential cell division protein that could be required for efficient cell constriction KOPIJCMJ_01500 1380346.JNIH01000014_gene897 1.3e-39 169.1 Actinobacteria Bacteria 2C7XW@1,2IQ5R@201174,32RR4@2 NA|NA|NA S Protein of unknown function (DUF3499) KOPIJCMJ_01501 471852.Tcur_4063 2e-170 605.5 Streptosporangiales manB GO:0003674,GO:0003824,GO:0004615,GO:0005975,GO:0008150,GO:0008152,GO:0016853,GO:0016866,GO:0016868,GO:0044238,GO:0071704 5.4.2.2,5.4.2.8 ko:K01840,ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 iECS88_1305.ECS88_2145,iECUMN_1333.ECUMN_2384,iUTI89_1310.UTI89_C2321 Bacteria 2GJQA@201174,4EGWS@85012,COG1109@1,COG1109@2 NA|NA|NA G Phosphoglucomutase/phosphomannomutase, C-terminal domain KOPIJCMJ_01502 298654.FraEuI1c_6060 2.8e-13 80.9 Frankiales ycaR GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.7.1.130 ko:K00912,ko:K09791 ko00540,ko01100,map00540,map01100 M00060 R04657 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 Bacteria 2HUT6@201174,4ETHY@85013,COG2835@1,COG2835@2 NA|NA|NA S Trm112p-like protein KOPIJCMJ_01503 134676.ACPL_1062 1.7e-91 342.8 Micromonosporales cat Bacteria 2GKSG@201174,4DAPD@85008,COG0053@1,COG0053@2 NA|NA|NA P cation diffusion facilitator family transporter KOPIJCMJ_01506 357808.RoseRS_1515 5.5e-12 77.8 Chloroflexia Bacteria 2DRD4@1,2G9Z1@200795,33B9X@2,377FH@32061 NA|NA|NA KOPIJCMJ_01507 477641.MODMU_2166 6.6e-49 200.7 Frankiales Bacteria 2IIBU@201174,308PC@2,4EV3D@85013,arCOG14808@1 NA|NA|NA S Domain of unknown function (DUF4956) KOPIJCMJ_01508 1869.MB27_41620 4.7e-48 198.4 Micromonosporales ygiF GO:0003674,GO:0003824,GO:0005488,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0043167,GO:0043169,GO:0046872,GO:0050355 3.6.1.25 ko:K18446 ko00000,ko01000 Bacteria 2II2C@201174,4DCSN@85008,COG3025@1,COG3025@2 NA|NA|NA S VTC domain KOPIJCMJ_01509 1095767.CAHD01000028_gene1705 4.4e-64 252.7 Cellulomonadaceae Bacteria 2GKIT@201174,2Z8AD@2,4F0EE@85016,arCOG08054@1 NA|NA|NA S Carbohydrate-binding domain-containing protein Cthe_2159 KOPIJCMJ_01511 1184607.AUCHE_08_00700 2.5e-60 238.8 Dermatophilaceae Bacteria 2GKFS@201174,4F6SG@85018,COG0745@1,COG0745@2 NA|NA|NA K Transcriptional regulatory protein, C terminal KOPIJCMJ_01513 1081644.IMCC13023_04080 8.6e-196 690.3 Microbacteriaceae Bacteria 2I7FH@201174,4FRRZ@85023,COG0457@1,COG0457@2 NA|NA|NA S Tetratricopeptide repeat KOPIJCMJ_01514 1081644.IMCC13023_04070 6.1e-47 194.5 Actinobacteria Bacteria 2B8JV@1,2H60Z@201174,321V3@2 NA|NA|NA KOPIJCMJ_01518 525909.Afer_0153 9.4e-23 112.8 Actinobacteria ko:K07483 ko00000 Bacteria 2GRDS@201174,COG2963@1,COG2963@2 NA|NA|NA L PFAM Transposase IS3 KOPIJCMJ_01519 656024.FsymDg_0094 8.8e-48 197.2 Actinobacteria ko:K07483,ko:K07497 ko00000 Bacteria 2IDYA@201174,COG2801@1,COG2801@2,COG2963@1,COG2963@2 NA|NA|NA L PFAM Transposase IS3 IS911 KOPIJCMJ_01520 298653.Franean1_4649 9.7e-128 463.4 Frankiales Bacteria 2GS79@201174,4EUP5@85013,COG3547@1,COG3547@2 NA|NA|NA L PFAM transposase IS116 IS110 IS902 family protein KOPIJCMJ_01521 68260.JOAY01000096_gene5411 9.2e-10 68.9 Actinobacteria Bacteria 2GKDY@201174,COG2801@1,COG2801@2 NA|NA|NA L PFAM Integrase catalytic KOPIJCMJ_01522 1136417.AZWE01000012_gene2545 2.6e-07 62.4 Micromonosporales pspC ko:K03973 ko00000,ko02048,ko03000 Bacteria 2GIVS@201174,4DAQE@85008,COG1983@1,COG1983@2 NA|NA|NA KT PspC domain KOPIJCMJ_01524 397278.JOJN01000009_gene3672 3.2e-43 181.0 Propionibacteriales Bacteria 2IKPX@201174,4DRBT@85009,COG4898@1,COG4898@2 NA|NA|NA S Uncharacterized protein conserved in bacteria (DUF2200) KOPIJCMJ_01526 284031.JNXD01000003_gene3705 3.2e-18 99.0 Bacteria Bacteria 2DFEX@1,2ZRKU@2 NA|NA|NA KOPIJCMJ_01528 33876.JNXY01000002_gene363 5e-51 209.5 Actinobacteria Bacteria 2IR52@201174,COG1525@1,COG1525@2 NA|NA|NA L Lamin Tail Domain KOPIJCMJ_01530 1081644.IMCC13023_00390 6.8e-104 384.0 Microbacteriaceae ko:K07086 ko00000 Bacteria 2I8DP@201174,4FRC1@85023,COG3329@1,COG3329@2 NA|NA|NA S Na+-dependent bicarbonate transporter superfamily KOPIJCMJ_01531 1211815.CBYP010000046_gene881 9.3e-20 102.8 Actinobacteria ko:K04752 ko00000 Bacteria 2H6FT@201174,COG0347@1,COG0347@2 NA|NA|NA E Belongs to the P(II) protein family KOPIJCMJ_01532 446462.Amir_6924 2.2e-98 365.9 Pseudonocardiales nagA 3.5.1.25 ko:K01443 ko00520,ko01130,map00520,map01130 R02059 RC00166,RC00300 ko00000,ko00001,ko01000 Bacteria 2GK1E@201174,4DX8Z@85010,COG1820@1,COG1820@2 NA|NA|NA G Belongs to the metallo-dependent hydrolases superfamily. NagA family KOPIJCMJ_01533 263358.VAB18032_00585 2.7e-167 595.5 Micromonosporales yheS_2 ko:K06158,ko:K18230 ko02010,map02010 ko00000,ko00001,ko01504,ko02000,ko03012 3.A.1.120 Bacteria 2GK9S@201174,4DA8K@85008,COG0488@1,COG0488@2 NA|NA|NA S ATPases associated with a variety of cellular activities KOPIJCMJ_01534 1078020.KEK_20058 4.5e-109 401.4 Mycobacteriaceae ko:K02012 ko02010,map02010 M00190 ko00000,ko00001,ko00002,ko02000 3.A.1.10 Bacteria 236RG@1762,2HPZ8@201174,COG1840@1,COG1840@2 NA|NA|NA P Extracellular solute-binding protein KOPIJCMJ_01535 318424.EU78_14165 8.2e-115 421.0 Mycobacteriaceae sfuB ko:K02011 ko02010,map02010 M00190 ko00000,ko00001,ko00002,ko02000 3.A.1.10 Bacteria 2347P@1762,2GKPT@201174,COG1178@1,COG1178@2 NA|NA|NA P binding-protein-dependent transport systems inner membrane component KOPIJCMJ_01536 1449069.JMLO01000017_gene3295 1.4e-28 133.7 Nocardiaceae VP1530 ko:K07164 ko00000 Bacteria 2GN5K@201174,4FWY1@85025,COG1579@1,COG1579@2,COG5473@1,COG5473@2 NA|NA|NA J Zn-ribbon protein possibly nucleic acid-binding KOPIJCMJ_01537 1122138.AQUZ01000081_gene4871 2.6e-44 186.0 Propionibacteriales mutT 3.6.1.55 ko:K03574,ko:K08296 ko00000,ko01000,ko03400 Bacteria 2I2N2@201174,4DWX8@85009,COG1051@1,COG1051@2,COG2062@1,COG2062@2 NA|NA|NA FT Phosphoglycerate mutase family KOPIJCMJ_01538 1304865.JAGF01000001_gene2382 1e-114 420.6 Actinobacteria Bacteria 2GJZH@201174,COG5607@1,COG5607@2 NA|NA|NA S CHAD domain containing protein KOPIJCMJ_01539 1894.JOER01000041_gene1494 4.3e-284 983.8 Actinobacteria ppk 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 2GJ0B@201174,COG0855@1,COG0855@2 NA|NA|NA P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) KOPIJCMJ_01540 35754.JNYJ01000038_gene4955 2.8e-81 308.9 Micromonosporales mshD GO:0000302,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006950,GO:0006979,GO:0008080,GO:0008150,GO:0008152,GO:0009058,GO:0009268,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0010125,GO:0010126,GO:0010447,GO:0016137,GO:0016138,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0033554,GO:0034599,GO:0034614,GO:0035447,GO:0035690,GO:0040007,GO:0042221,GO:0042493,GO:0042542,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044249,GO:0044272,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051186,GO:0051188,GO:0051704,GO:0051716,GO:0070301,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071468,GO:0071704,GO:0097237,GO:0104004,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659,GO:1901700,GO:1901701 2.3.1.189,2.7.4.1 ko:K00937,ko:K15520 ko00190,ko03018,map00190,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 2GM35@201174,4D8MC@85008,COG0454@1,COG0456@2 NA|NA|NA K Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol KOPIJCMJ_01541 28444.JODQ01000002_gene4547 2.7e-89 335.1 Streptosporangiales Bacteria 2GJGU@201174,4EI8P@85012,COG0745@1,COG0745@2 NA|NA|NA KT Transcriptional regulatory protein, C terminal KOPIJCMJ_01542 471852.Tcur_0600 3.6e-37 161.4 Streptosporangiales thiX 1.8.1.8 ko:K02199,ko:K03671,ko:K03672 ko04621,ko05418,map04621,map05418 ko00000,ko00001,ko01000,ko03110 Bacteria 2IKMI@201174,4EK0E@85012,COG0526@1,COG0526@2 NA|NA|NA CO Thioredoxin KOPIJCMJ_01543 436229.JOEH01000023_gene761 2.4e-32 145.2 Streptacidiphilus Bacteria 2AN8T@1,2I81P@201174,2NNJW@228398,327DN@2 NA|NA|NA S Domain of unknown function (DUF4395) KOPIJCMJ_01544 561175.KB894093_gene2870 9.2e-18 98.6 Streptosporangiales ko:K14340 ko00000,ko01000,ko01003 Bacteria 2GN7C@201174,4EPB5@85012,COG5305@1,COG5305@2 NA|NA|NA S Dolichyl-phosphate-mannose-protein mannosyltransferase KOPIJCMJ_01545 269800.Tfu_2924 1.8e-33 148.7 Streptosporangiales Bacteria 2IHT6@201174,4EJN0@85012,COG2044@1,COG2044@2 NA|NA|NA S DsrE/DsrF-like family KOPIJCMJ_01547 1120950.KB892795_gene2292 1.3e-40 172.9 Propionibacteriales GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 2GKGF@201174,4DQW9@85009,COG4044@1,COG4044@2 NA|NA|NA S May play a role in the intracellular transport of hydrophobic ligands KOPIJCMJ_01548 390989.JOEG01000027_gene2201 2.7e-31 141.7 Micromonosporales ko:K03711 ko00000,ko03000 Bacteria 2IFHB@201174,4DEKA@85008,COG0735@1,COG0735@2 NA|NA|NA P Belongs to the Fur family KOPIJCMJ_01549 1120950.KB892795_gene2294 3.8e-79 302.0 Propionibacteriales 1.5.99.5,2.1.2.10 ko:K00605,ko:K06980,ko:K22086 ko00260,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200 M00532 R00609,R01221,R02300,R04125 RC00022,RC00069,RC00183,RC00190,RC00557,RC02834 ko00000,ko00001,ko00002,ko01000,ko03016 Bacteria 2I4ER@201174,4DX1V@85009,COG0404@1,COG0404@2 NA|NA|NA E Glycine cleavage T-protein C-terminal barrel domain KOPIJCMJ_01550 1172188.KB911820_gene2608 1.1e-61 243.4 Intrasporangiaceae Bacteria 2H8JM@201174,4FG88@85021,COG0491@1,COG0491@2 NA|NA|NA S Metallo-beta-lactamase superfamily KOPIJCMJ_01551 452652.KSE_43730 9.9e-40 169.9 Kitasatospora dtd GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106026,GO:0106074,GO:0140098,GO:0140101,GO:1901360 ko:K07560 ko00000,ko01000,ko03016 Bacteria 2IKVR@201174,2M30U@2063,COG1490@1,COG1490@2 NA|NA|NA J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality KOPIJCMJ_01552 1128421.JAGA01000002_gene21 2.8e-10 73.2 unclassified Bacteria Bacteria 2NRMR@2323,COG0457@1,COG0457@2 NA|NA|NA O heat shock protein binding KOPIJCMJ_01553 1122138.AQUZ01000081_gene4842 6e-93 347.4 Propionibacteriales 2.3.1.247 ko:K18013 ko00310,map00310 R10564 RC02728,RC03199 ko00000,ko00001,ko01000 Bacteria 2I9EQ@201174,4DP9Q@85009,COG3246@1,COG3246@2 NA|NA|NA S beta-keto acid cleavage enzyme KOPIJCMJ_01554 1155714.KB891993_gene5428 4.3e-79 301.6 Actinobacteria ansA 3.5.1.1 ko:K01424 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 R00485 RC00010,RC02798 ko00000,ko00001,ko01000 Bacteria 2GJA7@201174,COG4448@1,COG4448@2 NA|NA|NA E L-asparaginase II KOPIJCMJ_01556 351607.Acel_0067 4.3e-33 147.5 Frankiales clgR_2 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 Bacteria 2IKVI@201174,4ET27@85013,COG1396@1,COG1396@2 NA|NA|NA K transcriptional regulator, XRE family KOPIJCMJ_01557 1206733.BAGC01000061_gene3397 1.3e-15 89.0 Nocardiaceae Bacteria 2EHMU@1,2HM2W@201174,33BDI@2,4G3KX@85025 NA|NA|NA S Protein of unknown function (DUF2516) KOPIJCMJ_01558 356851.JOAN01000015_gene2702 7.1e-81 307.4 Micromonosporales 2.1.1.104 ko:K00588 ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110 M00039,M00350 R01942,R06578 RC00003,RC00392 ko00000,ko00001,ko00002,ko01000 Bacteria 2GK2F@201174,4D8DF@85008,COG4122@1,COG4122@2 NA|NA|NA S O-methyltransferase activity KOPIJCMJ_01559 1120950.KB892790_gene2083 4.9e-102 377.5 Propionibacteriales gpmA GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016020,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0031323,GO:0031329,GO:0032787,GO:0032991,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0060255,GO:0062012,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031 5.4.2.11 ko:K01834 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 Bacteria 2GK8F@201174,4DND2@85009,COG0588@1,COG0588@2 NA|NA|NA G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate KOPIJCMJ_01560 1169161.KB897713_gene6602 1e-43 183.3 Actinobacteria Bacteria 2AZ39@1,2GMCY@201174,31R9K@2 NA|NA|NA S Putative bacterial sensory transduction regulator KOPIJCMJ_01561 644283.Micau_5680 1.7e-139 502.7 Micromonosporales mshA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016740,GO:0016757,GO:0016758,GO:0044237,GO:0044249,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659 2.4.1.250 ko:K15521 ko00000,ko01000 Bacteria 2GJ57@201174,4D8PR@85008,COG0438@1,COG0438@2 NA|NA|NA M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway KOPIJCMJ_01562 1463855.JOHV01000011_gene4088 6.5e-61 240.7 Actinobacteria phoU ko:K02039 ko00000 Bacteria 2GKAD@201174,COG0704@1,COG0704@2 NA|NA|NA P Plays a role in the regulation of phosphate uptake KOPIJCMJ_01563 43759.JNWK01000017_gene7629 4.4e-81 308.5 Actinobacteria senX3 GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009405,GO:0009987,GO:0016020,GO:0016310,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044464,GO:0046777,GO:0051704,GO:0071704,GO:0071944,GO:1901564 2.7.13.3 ko:K07636,ko:K07768,ko:K11383 ko02020,map02020 M00434,M00443,M00505 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 2GJY7@201174,COG5002@1,COG5002@2 NA|NA|NA T Histidine kinase KOPIJCMJ_01564 1122247.C731_0827 6.8e-95 353.6 Mycobacteriaceae Bacteria 234EX@1762,2GKFS@201174,COG0745@1,COG0745@2 NA|NA|NA K COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain KOPIJCMJ_01565 452652.KSE_34500 4.2e-09 68.2 Kitasatospora Bacteria 2E56G@1,2GK9W@201174,2M3DR@2063,32ZZ6@2 NA|NA|NA KOPIJCMJ_01566 105425.BBPL01000018_gene61 0.0 1126.7 Streptacidiphilus clpC ko:K03696 ko01100,map01100 ko00000,ko03110 Bacteria 2GJ77@201174,2NHD1@228398,COG0542@1,COG0542@2 NA|NA|NA O Bacterial TniB protein KOPIJCMJ_01567 1122611.KB903943_gene1465 1.5e-06 60.5 Streptosporangiales Bacteria 2E5CN@1,2GM9T@201174,3304R@2,4EJKG@85012 NA|NA|NA KOPIJCMJ_01568 1150864.MILUP08_46690 3e-129 468.4 Micromonosporales disA 2.7.7.85 ko:K07067 ko00000,ko01000 Bacteria 2GJ41@201174,4D9EZ@85008,COG1623@1,COG1623@2 NA|NA|NA L Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process KOPIJCMJ_01569 570268.ANBB01000033_gene2073 1.6e-141 509.6 Streptosporangiales radA GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 ko:K04485 ko00000,ko03400 Bacteria 2GMQ0@201174,4EG9C@85012,COG1066@1,COG1066@2 NA|NA|NA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function KOPIJCMJ_01570 467200.ACFA01000404_gene2616 3.4e-106 391.7 Actinobacteria Bacteria 2GJ6E@201174,COG1082@1,COG1082@2 NA|NA|NA G PFAM Xylose isomerase domain protein TIM barrel KOPIJCMJ_01572 1169152.AXVD01000023_gene3257 4.9e-15 88.2 Nocardiaceae ydiN ko:K03762 ko00000,ko02000 2.A.1.6.4 Bacteria 2HHY4@201174,4G1MV@85025,COG0477@1,COG0477@2,COG0500@1,COG2226@2 NA|NA|NA Q Mycolic acid cyclopropane synthetase KOPIJCMJ_01574 1043493.BBLU01000002_gene1838 5.7e-31 141.4 Bacteria ko:K16129 ko01054,map01054 ko00000,ko00001,ko01008 Bacteria COG0500@1,COG2226@2 NA|NA|NA Q methyltransferase KOPIJCMJ_01576 1206732.BAGD01000097_gene4238 2.8e-32 145.6 Nocardiaceae Bacteria 2IMKC@201174,4G03M@85025,COG2021@1,COG2021@2 NA|NA|NA E Serine aminopeptidase, S33 KOPIJCMJ_01577 40571.JOEA01000029_gene5793 2e-22 113.6 Bacteria Bacteria 2E7BJ@1,331UW@2 NA|NA|NA KOPIJCMJ_01578 1397278.AYMV01000001_gene448 3.4e-42 178.7 Actinobacteria yycO Bacteria 2INZ0@201174,COG3863@1,COG3863@2 NA|NA|NA S Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family KOPIJCMJ_01581 590998.Celf_3040 3.5e-28 132.1 Bacteria Bacteria 2EFAB@1,33939@2 NA|NA|NA KOPIJCMJ_01582 590998.Celf_3045 6e-70 271.2 Bacteria 2.4.1.289 ko:K07011,ko:K16870 ko00000,ko01000,ko01003 Bacteria COG1216@1,COG1216@2 NA|NA|NA V Glycosyl transferase, family 2 KOPIJCMJ_01583 1380354.JIAN01000008_gene3362 2.6e-36 159.1 Actinobacteria 3.2.1.91 ko:K19668 ko00500,ko01100,ko02020,map00500,map01100,map02020 R02886,R11308 RC00799 ko00000,ko00001,ko01000 GH6 Bacteria 2GN7G@201174,COG3291@1,COG3291@2,COG3420@1,COG3420@2 NA|NA|NA P PFAM PKD domain containing protein KOPIJCMJ_01586 1193181.BN10_880001 7.2e-172 610.1 Intrasporangiaceae pntA GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008746,GO:0008750,GO:0009117,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016652,GO:0019362,GO:0019637,GO:0031224,GO:0031226,GO:0034641,GO:0036094,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0046483,GO:0046496,GO:0046983,GO:0048037,GO:0050661,GO:0050662,GO:0051186,GO:0051287,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072524,GO:0097159,GO:1901265,GO:1901360,GO:1901363,GO:1901564 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 R00112 RC00001 ko00000,ko00001,ko01000 iEcE24377_1341.EcE24377A_1810 Bacteria 2I2FZ@201174,4FEB2@85021,COG3288@1,COG3288@2 NA|NA|NA C NAD(P) transhydrogenase subunit alpha KOPIJCMJ_01587 1120948.KB903247_gene4611 2e-88 333.2 Pseudonocardiales 6.4.1.3,6.4.1.4 ko:K01965,ko:K01968 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00036,M00373,M00741 R01859,R04138 RC00097,RC00367,RC00609,RC00942 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIZP@201174,4DZTM@85010,COG4770@1,COG4770@2 NA|NA|NA I Acetyl propionyl-CoA carboxylase, alpha subunit KOPIJCMJ_01590 1713.JOFV01000020_gene1360 9.1e-13 79.7 Cellulomonadaceae 2.8.1.7 ko:K04085,ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 Bacteria 2GSF4@201174,4F2Z8@85016,COG0425@1,COG0425@2 NA|NA|NA O Sulfurtransferase TusA KOPIJCMJ_01591 1394178.AWOO02000084_gene1172 1e-90 340.5 Streptosporangiales 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 Bacteria 2GJ2B@201174,4EHSY@85012,COG1104@1,COG1104@2 NA|NA|NA E Beta-eliminating lyase KOPIJCMJ_01592 1504319.GM45_0705 5.6e-70 271.2 unclassified Actinobacteria (class) ctaC GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0040007,GO:0042773,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044238,GO:0044281,GO:0044403,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0051704,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 Bacteria 2GNXA@201174,3UWMS@52018,COG1622@1,COG1622@2 NA|NA|NA C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) KOPIJCMJ_01593 224914.BMEI0339 4e-11 73.6 Brucellaceae tolB GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0009719,GO:0009987,GO:0010033,GO:0010243,GO:0015031,GO:0015833,GO:0015893,GO:0017038,GO:0019534,GO:0019904,GO:0022857,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0032991,GO:0033036,GO:0042221,GO:0042493,GO:0042597,GO:0042886,GO:0042891,GO:0043213,GO:0044464,GO:0044877,GO:0045184,GO:0046677,GO:0046678,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0070887,GO:0071236,GO:0071237,GO:0071310,GO:0071417,GO:0071495,GO:0071702,GO:0071705,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1901998 ko:K03641 ko00000,ko02000 2.C.1.2 Bacteria 1J1M8@118882,1MV09@1224,2TR03@28211,COG0823@1,COG0823@2 NA|NA|NA U Involved in the TonB-independent uptake of proteins KOPIJCMJ_01595 351607.Acel_0144 1.6e-74 286.6 Frankiales Bacteria 2GJV7@201174,4ESVM@85013,COG1609@1,COG1609@2 NA|NA|NA K periplasmic binding protein LacI transcriptional regulator KOPIJCMJ_01596 710111.FraQA3DRAFT_4644 1.1e-20 106.3 Actinobacteria Bacteria 2GJYB@201174,COG5485@1,COG5485@2 NA|NA|NA S SnoaL-like polyketide cyclase KOPIJCMJ_01597 1306406.ASHX01000001_gene4395 4.5e-124 451.1 Actinobacteria yhhW_2 ko:K06911,ko:K06975 ko00000 Bacteria 2GM9P@201174,COG1741@1,COG1741@2,COG2388@1,COG2388@2 NA|NA|NA S Belongs to the pirin family KOPIJCMJ_01598 1172188.KB911825_gene3711 1.4e-38 166.0 Intrasporangiaceae Bacteria 2IMM4@201174,4FGQX@85021,COG3832@1,COG3832@2 NA|NA|NA S Polyketide cyclase / dehydrase and lipid transport KOPIJCMJ_01599 1128421.JAGA01000002_gene1272 8.7e-29 135.2 unclassified Bacteria 2.7.7.65 ko:K21088 ko02026,map02026 ko00000,ko00001,ko01000 Bacteria 2NP1A@2323,COG5001@1,COG5001@2 NA|NA|NA T Putative diguanylate phosphodiesterase KOPIJCMJ_01600 314278.NB231_10523 3e-156 558.1 Gammaproteobacteria fbp 3.1.3.11,4.1.2.13 ko:K01622 ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00003 R00762,R01068,R01070,R02568,R04780 RC00017,RC00438,RC00439 ko00000,ko00001,ko00002,ko01000 Bacteria 1MXM7@1224,1SKUG@1236,COG1980@1,COG1980@2 NA|NA|NA G Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) KOPIJCMJ_01601 1035308.AQYY01000002_gene263 1.8e-147 528.9 Clostridia ko:K19265 ko00000,ko01000 Bacteria 1TRS0@1239,247RJ@186801,COG0667@1,COG0667@2 NA|NA|NA C aldo keto reductase KOPIJCMJ_01602 68170.KL590486_gene9693 7.6e-45 187.6 Pseudonocardiales ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2IING@201174,4E5D6@85010,COG1277@1,COG1277@2 NA|NA|NA S ABC-2 family transporter protein KOPIJCMJ_01603 1227352.C173_04326 1.4e-61 243.4 Paenibacillaceae ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1TPBQ@1239,26VNN@186822,4HBXP@91061,COG1131@1,COG1131@2 NA|NA|NA V Bacitracin ABC transporter, ATP-binding protein KOPIJCMJ_01604 110319.CF8_1033 1.5e-18 99.0 Propionibacteriales cbiL ko:K02007,ko:K02009,ko:K16915 ko02010,map02010 M00245,M00246 ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 iAF987.Gmet_2441 Bacteria 2GRUA@201174,4DS6B@85009,COG0310@1,COG0310@2 NA|NA|NA P PDGLE domain KOPIJCMJ_01605 1957.JODX01000015_gene1376 3e-53 215.3 Actinobacteria cbiM ko:K02007,ko:K16915 ko02010,map02010 M00245,M00246 ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 Bacteria 2GK2U@201174,COG0310@1,COG0310@2 NA|NA|NA P Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import KOPIJCMJ_01607 935866.JAER01000040_gene512 1.2e-103 382.9 Propionibacteriales Bacteria 2GJU1@201174,4DN4M@85009,COG1028@1,COG1028@2 NA|NA|NA IQ KR domain KOPIJCMJ_01608 714083.JH370377_gene2640 1.4e-22 112.1 Microbacteriaceae Bacteria 2DNW5@1,2IQ5T@201174,32ZGI@2,4FQ68@85023 NA|NA|NA S Rho termination factor, N-terminal domain KOPIJCMJ_01612 67352.JODS01000002_gene1441 3.9e-36 157.5 Actinobacteria yjqA Bacteria 2IHVS@201174,3172B@2,arCOG12631@1 NA|NA|NA S Bacterial PH domain KOPIJCMJ_01613 593907.Celgi_0778 8.8e-58 230.3 Cellulomonadaceae Bacteria 2H8PB@201174,4F2A5@85016,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily KOPIJCMJ_01614 1304885.AUEY01000002_gene350 6.5e-16 89.4 Desulfobacterales 3.1.6.1 ko:K01130,ko:K01138 ko00140,ko00600,map00140,map00600 R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 Bacteria 1PFYE@1224,2MNWS@213118,2WQC7@28221,43A2J@68525,COG3119@1,COG3119@2 NA|NA|NA P Sulfatase KOPIJCMJ_01615 1155718.KB891889_gene6846 4.3e-204 717.6 Actinobacteria cimA 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GKYT@201174,COG0119@1,COG0119@2 NA|NA|NA E Belongs to the alpha-IPM synthase homocitrate synthase family KOPIJCMJ_01616 981369.JQMJ01000004_gene5700 6.8e-83 313.9 Streptacidiphilus fahA Bacteria 2GN2G@201174,2NF0A@228398,COG0179@1,COG0179@2 NA|NA|NA Q Domain of unknown function (DUF2437) KOPIJCMJ_01617 1504319.GM45_4290 2e-187 662.1 unclassified Actinobacteria (class) gltX GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 iNJ661.Rv2992c Bacteria 2GJJS@201174,3UW9W@52018,COG0008@1,COG0008@2 NA|NA|NA J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) KOPIJCMJ_01618 272844.PAB2253 2.7e-33 149.4 Thermococci pgk2 ko:K05715 R02664 RC00002,RC00017 ko00000,ko01000 Archaea 242Y8@183968,2XVZC@28890,COG2074@1,arCOG01967@2157 NA|NA|NA F 2-phosphoglycerate kinase KOPIJCMJ_01621 1134445.AJJM01000058_gene2331 1.1e-95 356.3 Actinobacteria ltbR Bacteria 2GKB0@201174,COG1414@1,COG1414@2 NA|NA|NA K transcriptional regulator KOPIJCMJ_01625 1173027.Mic7113_0392 2.8e-37 163.3 Cyanobacteria pslG ko:K21000 ko02025,map02025 ko00000,ko00001 GH39 Bacteria 1GANI@1117,COG3664@1,COG3664@2 NA|NA|NA G PFAM Glycosyl hydrolases family 39 KOPIJCMJ_01626 1211815.CBYP010000024_gene1543 1.6e-122 446.0 Actinobacteria rgpA ko:K12996 ko00000,ko01000,ko01003,ko01005 GT4 Bacteria 2IBM0@201174,COG0438@1,COG0438@2 NA|NA|NA M Glycosyltransferase KOPIJCMJ_01627 110319.CF8_3325 4.4e-35 156.4 Bacteria 2.1.1.107,2.1.1.294,2.7.1.181,2.7.11.1 ko:K02496,ko:K05802,ko:K08884,ko:K18827 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03194,R10657,R10658 RC00002,RC00003,RC00078,RC00871,RC03220 ko00000,ko00001,ko00002,ko01000,ko01001,ko01005,ko02000 1.A.23.1.1 Bacteria COG2959@1,COG2959@2 NA|NA|NA H enzyme of heme biosynthesis KOPIJCMJ_01628 263358.VAB18032_22820 2.7e-63 249.2 Micromonosporales wbbL_1 ko:K07011 ko00000 Bacteria 2HEV5@201174,4D9DN@85008,COG1216@1,COG1216@2 NA|NA|NA S Glycosyl transferase family group 2 KOPIJCMJ_01629 367299.JOEE01000003_gene3004 1.4e-72 280.8 Actinobacteria Bacteria 2IT2M@201174,COG1807@1,COG1807@2 NA|NA|NA M Dolichyl-phosphate-mannose-protein mannosyltransferase KOPIJCMJ_01630 1304865.JAGF01000001_gene119 3.4e-155 555.4 Actinobacteria yvnB 3.1.4.53 ko:K03651 ko00230,ko02025,map00230,map02025 R00191 RC00296 ko00000,ko00001,ko01000 Bacteria 2GN7G@201174,COG1409@1,COG1409@2,COG3291@1,COG3291@2 NA|NA|NA P PFAM PKD domain containing protein KOPIJCMJ_01631 1136417.AZWE01000070_gene1255 9.9e-76 290.8 Micromonosporales GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0015562,GO:0022857,GO:0042221,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0055085 Bacteria 2HB3P@201174,4DCV1@85008,COG2271@1,COG2271@2 NA|NA|NA G PFAM major facilitator superfamily MFS_1 KOPIJCMJ_01632 931627.MycrhDRAFT_2921 2.7e-241 841.6 Mycobacteriaceae fimV_2 ko:K19719 ko04151,ko04510,ko04512,ko04974,ko05165,map04151,map04510,map04512,map04974,map05165 ko00000,ko00001,ko00536 Bacteria 232WS@1762,2GJ7M@201174,COG0247@1,COG0247@2,COG3266@1,COG3266@2 NA|NA|NA C Fe-S oxidoreductase KOPIJCMJ_01634 1123320.KB889692_gene178 2e-110 406.0 Actinobacteria cpaF ko:K02283 ko00000,ko02035,ko02044 Bacteria 2GKKJ@201174,COG4962@1,COG4962@2 NA|NA|NA U Type ii secretion system protein e KOPIJCMJ_01635 1077972.ARGLB_008_01400 2.1e-20 106.7 Micrococcaceae cpaE GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 ko:K04562 ko00000,ko02035 Bacteria 1W9WT@1268,2GIVN@201174,COG0455@1,COG0455@2 NA|NA|NA D bacterial-type flagellum organization KOPIJCMJ_01636 570268.ANBB01000058_gene4298 3.8e-44 185.3 Streptosporangiales Bacteria 2GIT8@201174,4EG60@85012,COG3177@1,COG3177@2 NA|NA|NA S Filamentation induced by cAMP protein fic KOPIJCMJ_01637 1454010.JEOE01000013_gene2251 1.3e-88 332.8 Cellulomonadaceae acsA 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 2GJCG@201174,4F12N@85016,COG0365@1,COG0365@2 NA|NA|NA I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA KOPIJCMJ_01638 1005048.CFU_0400 1.6e-07 60.5 Oxalobacteraceae rpsJ GO:0001072,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006355,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0015935,GO:0019219,GO:0019222,GO:0019538,GO:0022626,GO:0022627,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043244,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0140110,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2001141 ko:K02946 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1RGWF@1224,2VSDQ@28216,474C4@75682,COG0051@1,COG0051@2 NA|NA|NA J Involved in the binding of tRNA to the ribosomes KOPIJCMJ_01639 1116232.AHBF01000113_gene4604 7.3e-195 686.8 Actinobacteria pgm GO:0000271,GO:0003674,GO:0003824,GO:0004614,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0005996,GO:0006006,GO:0006012,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0016868,GO:0019318,GO:0019320,GO:0019388,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0055114,GO:0071704,GO:1901575,GO:1901576 5.4.2.2 ko:K01835 ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00549 R00959,R01057,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 iAPECO1_1312.APECO1_1376,iECED1_1282.ECED1_0670,iECNA114_1301.ECNA114_0627,iECOK1_1307.ECOK1_0699,iECP_1309.ECP_0709,iECS88_1305.ECS88_0725,iJN678.pgm,iLF82_1304.LF82_1632,iNRG857_1313.NRG857_03110,iUMN146_1321.UM146_14115,iYL1228.KPN_00711 Bacteria 2H1PI@201174,COG0033@1,COG0033@2 NA|NA|NA G Phosphoglucomutase KOPIJCMJ_01640 313589.JNB_07719 5.8e-83 313.9 Intrasporangiaceae fmt2 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 Bacteria 2GKJH@201174,4FEFV@85021,COG1611@1,COG1611@2 NA|NA|NA S Belongs to the LOG family KOPIJCMJ_01641 1404245.CGLY_03165 7.4e-29 134.0 Corynebacteriaceae Bacteria 22JPX@1653,2GKFS@201174,COG0745@1,COG0745@2 NA|NA|NA T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain KOPIJCMJ_01642 649349.Lbys_1178 1.7e-36 159.1 Cytophagia mgsA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0008150,GO:0008152,GO:0008929,GO:0009058,GO:0009438,GO:0009987,GO:0016829,GO:0016835,GO:0016838,GO:0019242,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0071704,GO:1901576 4.2.3.3 ko:K01734 ko00640,ko01120,map00640,map01120 R01016 RC00424 ko00000,ko00001,ko01000 iECUMN_1333.ECUMN_1153,iYL1228.KPN_00992 Bacteria 47PW5@768503,4NQJ9@976,COG1803@1,COG1803@2 NA|NA|NA G MGS-like domain KOPIJCMJ_01643 67373.JOBF01000047_gene1741 1.2e-29 136.3 Actinobacteria lytR2 Bacteria 2GJJJ@201174,COG1316@1,COG1316@2 NA|NA|NA K cell envelope-related transcriptional attenuator KOPIJCMJ_01644 710685.MycrhN_3684 1.7e-33 149.4 Mycobacteriaceae Bacteria 232CS@1762,28JRZ@1,2H9EF@201174,2Z9HI@2 NA|NA|NA S Domain of unknown function (DUF4126) KOPIJCMJ_01645 653045.Strvi_0527 5.4e-21 107.1 Actinobacteria purS 6.3.2.6,6.3.5.3 ko:K01923,ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463,R04591 RC00010,RC00064,RC00162,RC01160 ko00000,ko00001,ko00002,ko01000 iYO844.BSU06460 Bacteria 2GQV4@201174,COG1828@1,COG1828@2 NA|NA|NA F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL KOPIJCMJ_01646 452652.KSE_38460 5.3e-98 364.0 Kitasatospora purQ GO:0003674,GO:0003824,GO:0004642,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 Bacteria 2GMJY@201174,2M20R@2063,COG0047@1,COG0047@2 NA|NA|NA F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL KOPIJCMJ_01647 68570.DC74_4016 0.0 1122.5 Actinobacteria purL GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKG6@201174,COG0046@1,COG0046@2 NA|NA|NA F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL KOPIJCMJ_01648 1120948.KB903217_gene1248 9.4e-48 196.8 Pseudonocardiales Bacteria 2II0D@201174,4E47X@85010,COG4430@1,COG4430@2 NA|NA|NA S Bacteriocin-protection, YdeI or OmpD-Associated KOPIJCMJ_01649 1122602.ATXP01000017_gene2260 4.8e-26 124.4 Micrococcaceae Bacteria 1W9SC@1268,2IQBF@201174,COG3255@1,COG3255@2 NA|NA|NA I Sterol carrier protein KOPIJCMJ_01651 526225.Gobs_1522 7.4e-200 703.4 Frankiales yjjK GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 Bacteria 2GKBQ@201174,4ERN5@85013,COG0488@1,COG0488@2 NA|NA|NA S ABC transporter KOPIJCMJ_01652 314230.DSM3645_19063 0.0 1179.9 Planctomycetes dld ko:K18930 ko00000 Bacteria 2IYAH@203682,COG0247@1,COG0247@2,COG0277@1,COG0277@2 NA|NA|NA C FAD linked oxidases, C-terminal domain KOPIJCMJ_01653 983917.RGE_19390 2.4e-114 419.5 unclassified Burkholderiales ko:K03281,ko:K07085 ko00000 2.A.49,2.A.81 Bacteria 1KNQF@119065,1MUVM@1224,2VN42@28216,COG0569@1,COG0569@2,COG2985@1,COG2985@2 NA|NA|NA P Predicted Permease Membrane Region KOPIJCMJ_01654 1137269.AZWL01000007_gene4285 1.3e-165 589.7 Actinobacteria 3.2.1.10,3.2.1.20,3.2.1.93 ko:K01182,ko:K01187,ko:K01226 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00028,R00801,R00802,R00837,R01718,R01791,R06087,R06088,R06113,R06199 RC00028,RC00049,RC00059,RC00077,RC00451 ko00000,ko00001,ko01000 GH13,GH31 Bacteria 2GKS4@201174,COG0366@1,COG0366@2 NA|NA|NA G alpha amylase, catalytic KOPIJCMJ_01655 1463885.KL578480_gene3542 5.3e-42 177.2 Actinobacteria glbO GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008144,GO:0008150,GO:0015669,GO:0015671,GO:0015893,GO:0016020,GO:0019825,GO:0020037,GO:0036094,GO:0042221,GO:0042493,GO:0044464,GO:0046906,GO:0048037,GO:0050896,GO:0051179,GO:0051234,GO:0071944,GO:0097159,GO:1901363 ko:K06886 ko00000 Bacteria 2IKPF@201174,COG2346@1,COG2346@2 NA|NA|NA O PFAM globin KOPIJCMJ_01656 1123320.KB889629_gene7846 1.9e-188 665.6 Actinobacteria Bacteria 2GIZA@201174,COG0702@1,COG0702@2 NA|NA|NA GM Nad-dependent epimerase dehydratase KOPIJCMJ_01657 1089455.MOPEL_132_00510 5e-59 235.0 Dermatophilaceae ko:K22044 ko00000,ko02000 1.A.23.3 Bacteria 2GMFK@201174,4F6NP@85018,COG0668@1,COG0668@2 NA|NA|NA M Mechanosensitive ion channel KOPIJCMJ_01658 1454010.JEOE01000011_gene2418 1.4e-218 766.1 Cellulomonadaceae malQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.4.1.18,2.4.1.25,3.2.1.196,5.4.99.15 ko:K00700,ko:K00705,ko:K02438,ko:K06044 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01824,R02110,R02111,R05196,R09995 RC00049 ko00000,ko00001,ko00002,ko01000,ko04147 CBM48,GH13,GH77 iJN678.malQ Bacteria 2GM5Z@201174,4F0RR@85016,COG1640@1,COG1640@2 NA|NA|NA G PFAM glycoside hydrolase family 77 KOPIJCMJ_01659 1120936.KB907209_gene1749 7.9e-189 667.2 Streptosporangiales 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 Bacteria 2GJJ4@201174,4EHVC@85012,COG0308@1,COG0308@2 NA|NA|NA E ERAP1-like C-terminal domain KOPIJCMJ_01660 471852.Tcur_2292 0.0 1636.7 Streptosporangiales metH GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0030312,GO:0032259,GO:0042084,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 Bacteria 2GM5Q@201174,4EFW6@85012,COG0646@1,COG0646@2,COG1410@1,COG1410@2 NA|NA|NA E B12 binding domain KOPIJCMJ_01661 1120936.KB907219_gene3210 1e-40 173.7 Streptosporangiales hisE Bacteria 2GJNG@201174,4EITJ@85012,COG0637@1,COG0637@2 NA|NA|NA S Haloacid dehalogenase-like hydrolase KOPIJCMJ_01662 1385519.N801_08145 2.1e-93 349.0 Intrasporangiaceae ko:K02003 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GJN6@201174,4FF61@85021,COG1136@1,COG1136@2 NA|NA|NA V ABC transporter, ATP-binding protein KOPIJCMJ_01663 1380393.JHVP01000004_gene618 9.5e-174 617.5 Frankiales ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 2H37M@201174,4ERZ6@85013,COG3127@1,COG3127@2 NA|NA|NA Q MacB-like periplasmic core domain KOPIJCMJ_01664 351607.Acel_1515 1.4e-264 918.7 Frankiales infB ko:K02519 ko00000,ko03012,ko03029 Bacteria 2GKPH@201174,4ERI2@85013,COG0532@1,COG0532@2 NA|NA|NA J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex KOPIJCMJ_01665 591158.SSMG_04921 1.4e-28 132.1 Actinobacteria ylxP ko:K09764 ko00000 Bacteria 2IQW4@201174,COG1550@1,COG1550@2 NA|NA|NA S protein conserved in bacteria KOPIJCMJ_01666 479433.Caci_7740 3.1e-49 201.4 Actinobacteria rbfA ko:K02834 ko00000,ko03009 Bacteria 2IKXP@201174,COG0858@1,COG0858@2 NA|NA|NA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA KOPIJCMJ_01667 1304865.JAGF01000001_gene3790 1.1e-79 303.5 Cellulomonadaceae truB GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 ko:K03177 ko00000,ko01000,ko03016 Bacteria 2GJZK@201174,4F0NH@85016,COG0130@1,COG0130@2 NA|NA|NA J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs KOPIJCMJ_01668 1283283.ATXA01000005_gene2038 5e-156 557.8 Frankiales pepP 3.4.11.9 ko:K01262 ko00000,ko01000,ko01002 Bacteria 2GM7D@201174,4ERTK@85013,COG0006@1,COG0006@2 NA|NA|NA E Creatinase/Prolidase N-terminal domain KOPIJCMJ_01669 219305.MCAG_04356 2.9e-75 288.9 Micromonosporales ribF GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008531,GO:0009058,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009124,GO:0009156,GO:0009161,GO:0009165,GO:0009231,GO:0009259,GO:0009260,GO:0009398,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0034654,GO:0042364,GO:0042726,GO:0042727,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046390,GO:0046444,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKQF@201174,4D8XR@85008,COG0196@1,COG0196@2 NA|NA|NA H Belongs to the ribF family KOPIJCMJ_01670 28444.JODQ01000001_gene2722 1.6e-34 151.8 Streptosporangiales rpsO GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006378,GO:0006396,GO:0006397,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016071,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031123,GO:0031124,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043631,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02956 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IQA0@201174,4EK2G@85012,COG0184@1,COG0184@2 NA|NA|NA J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome KOPIJCMJ_01674 1463845.JOIG01000002_gene2537 2.3e-50 205.7 Actinobacteria 3.1.3.3,3.1.3.73,5.4.2.11 ko:K01834,ko:K02226,ko:K22305 ko00010,ko00260,ko00680,ko00860,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003,M00122 R00582,R01518,R04594,R11173 RC00017,RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 Bacteria 2GK8N@201174,COG0406@1,COG0406@2 NA|NA|NA G phosphoglycerate mutase KOPIJCMJ_01675 253839.SSNG_01507 5.7e-44 184.1 Actinobacteria Bacteria 298YA@1,2GIYI@201174,2ZW25@2 NA|NA|NA S Protein of unknown function (DUF3090) KOPIJCMJ_01677 1120959.ATXF01000009_gene663 2.7e-52 211.5 Microbacteriaceae narG 1.7.5.1 ko:K00370 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000 5.A.3.1 Bacteria 2GKZU@201174,4FMZS@85023,COG5013@1,COG5013@2 NA|NA|NA C Molybdopterin oxidoreductase Fe4S4 domain KOPIJCMJ_01678 1123024.AUII01000046_gene3923 6.1e-246 856.7 Pseudonocardiales narH 1.7.5.1 ko:K00371 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000 5.A.3.1 Bacteria 2GJ8P@201174,4DYH1@85010,COG1140@1,COG1140@2 NA|NA|NA C Nitrate reductase beta subunit KOPIJCMJ_01679 1127134.NOCYR_4275 3.1e-45 188.7 Nocardiaceae narJ GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016530,GO:0022607,GO:0034622,GO:0042126,GO:0042128,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0051131,GO:0065003,GO:0071704,GO:0071840,GO:0071941,GO:0140104,GO:2001057 ko:K00373,ko:K17052 ko02020,map02020 ko00000,ko00001,ko02000 5.A.3.8 iE2348C_1286.E2348C_1350,iECABU_c1320.ECABU_c15020,iECIAI1_1343.ECIAI1_1469,iECO103_1326.ECO103_1331,iECO111_1330.ECO111_1557,iECW_1372.ECW_m1594,iEKO11_1354.EKO11_2354,iLF82_1304.LF82_1462,iNRG857_1313.NRG857_06280,iSSON_1240.SSON_1659,iWFL_1372.ECW_m1594,iYO844.BSU37260,ic_1306.c1687 Bacteria 2IAQV@201174,4FWCV@85025,COG2180@1,COG2180@2 NA|NA|NA C Nitrate reductase KOPIJCMJ_01680 1429046.RR21198_1930 3e-88 331.6 Nocardiaceae narI GO:0001666,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006950,GO:0008150,GO:0008152,GO:0008940,GO:0009055,GO:0009061,GO:0009325,GO:0009628,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016661,GO:0019645,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0036293,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044799,GO:0045333,GO:0046906,GO:0048037,GO:0050896,GO:0055114,GO:0070469,GO:0070470,GO:0070482,GO:0071944,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901363,GO:1902494,GO:1990204 1.7.5.1 ko:K00370,ko:K00374,ko:K02575 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00615,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 2.A.1.8,5.A.3.1 iEC042_1314.EC042_1594,iECABU_c1320.ECABU_c17020,iECUMN_1333.ECUMN_1718,iSF_1195.SF1230,ic_1306.c1897 Bacteria 2GJVI@201174,4FWVI@85025,COG2181@1,COG2181@2 NA|NA|NA C nitrate reductase, gamma subunit KOPIJCMJ_01681 398513.BBNG_01119 2.4e-26 124.8 Bifidobacteriales Bacteria 2IHSV@201174,4D0ZF@85004,COG1917@1,COG1917@2 NA|NA|NA S Cupin 2, conserved barrel domain protein KOPIJCMJ_01682 285535.JOEY01000026_gene9021 1.2e-59 236.5 Actinobacteria Bacteria 2GJ46@201174,COG2197@1,COG2197@2 NA|NA|NA T response regulator KOPIJCMJ_01683 285535.JOEY01000026_gene9022 1.6e-59 236.9 Actinobacteria Bacteria 2GJEG@201174,COG4585@1,COG4585@2 NA|NA|NA T Histidine kinase KOPIJCMJ_01685 2045.KR76_20720 1.6e-35 155.6 Propionibacteriales Bacteria 2IPEW@201174,4DS1Z@85009,COG1765@1,COG1765@2 NA|NA|NA O OsmC-like protein KOPIJCMJ_01686 436229.JOEH01000017_gene6907 1.7e-67 262.3 Streptacidiphilus 2.3.1.128 ko:K01163,ko:K03790 ko00000,ko01000,ko03009 Bacteria 2H4AD@201174,2NKG7@228398,COG1670@1,COG1670@2 NA|NA|NA J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins KOPIJCMJ_01688 1306174.JODP01000011_gene6779 6e-14 83.2 Actinobacteria Bacteria 2GJ46@201174,COG2197@1,COG2197@2 NA|NA|NA T response regulator KOPIJCMJ_01689 1246995.AFR_11420 1.4e-36 159.8 Bacteria Bacteria 2E1Q9@1,32X0K@2 NA|NA|NA KOPIJCMJ_01691 1449347.JQLN01000007_gene1838 3.1e-54 219.2 Kitasatospora 1.17.1.1 ko:K00523 ko00520,map00520 R03391,R03392 RC00230 ko00000,ko00001,ko01000 Bacteria 2HE37@201174,2M269@2063,COG1018@1,COG1018@2 NA|NA|NA C Ferric reductase like transmembrane component KOPIJCMJ_01693 315749.Bcer98_2749 5e-150 538.1 Bacillus ptsG GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.1.193,2.7.1.199,2.7.1.208,2.7.1.211 ko:K02755,ko:K02756,ko:K02757,ko:K02778,ko:K02803,ko:K02804,ko:K02809,ko:K02810,ko:K20107,ko:K20108,ko:K20116,ko:K20117,ko:K20118 ko00010,ko00500,ko00520,ko02060,ko05111,map00010,map00500,map00520,map02060,map05111 M00265,M00267,M00269,M00271,M00806,M00809 R00811,R02738,R04111,R05199 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.1,4.A.1.1.11,4.A.1.1.12,4.A.1.1.13,4.A.1.1.14,4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7,4.A.1.1.9,4.A.1.2.1,4.A.1.2.10,4.A.1.2.11,4.A.1.2.12,4.A.1.2.2,4.A.1.2.5,4.A.1.2.6,4.A.1.2.9 Bacteria 1TPJ8@1239,1ZC48@1386,4HA8X@91061,COG1263@1,COG1263@2,COG1264@1,COG1264@2,COG2190@1,COG2190@2 NA|NA|NA G phosphotransferase system KOPIJCMJ_01694 1280688.AUJB01000008_gene544 5.9e-48 198.0 Pseudobutyrivibrio ko:K02538 ko00000,ko03000 Bacteria 1TT5A@1239,24931@186801,3NGRF@46205,COG3711@1,COG3711@2 NA|NA|NA K CAT RNA binding domain KOPIJCMJ_01695 76636.JOEC01000002_gene2779 7.1e-15 85.9 Microbacteriaceae ko:K09946 ko00000 Bacteria 2GQUP@201174,4FQ8G@85023,COG3422@1,COG3422@2 NA|NA|NA S Domain of unknown function (DUF1508) KOPIJCMJ_01697 471852.Tcur_2117 5.5e-42 178.7 Streptosporangiales Bacteria 2GN1J@201174,4EJA0@85012,COG5650@1,COG5650@2 NA|NA|NA S Glycosyltransferase family 87 KOPIJCMJ_01698 211114.JOEF01000010_gene3310 1.4e-131 476.1 Pseudonocardiales carB GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 iAF1260.b0033,iBWG_1329.BWG_0031,iECDH10B_1368.ECDH10B_0034,iECDH1ME8569_1439.ECDH1ME8569_0031,iECUMN_1333.ECUMN_0034,iEcDH1_1363.EcDH1_3566,iJN746.PP_4723,iJO1366.b0033,iJR904.b0033,iPC815.YPO0482,iY75_1357.Y75_RS00170,iYL1228.KPN_00041 Bacteria 2GK5N@201174,4E0DG@85010,COG0458@1,COG0458@2 NA|NA|NA EF Belongs to the CarB family KOPIJCMJ_01699 367299.JOEE01000005_gene3472 4.1e-97 361.3 Intrasporangiaceae pyrK ko:K02823 ko00240,ko01100,map00240,map01100 ko00000,ko00001 Bacteria 2HQ24@201174,4FFS3@85021,COG0543@1,COG0543@2 NA|NA|NA C Dihydroorotate oxidase KOPIJCMJ_01700 477641.MODMU_3319 5.9e-119 434.1 Frankiales pyrD GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.98.1 ko:K00226,ko:K02823,ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01867,R01869 RC00051 ko00000,ko00001,ko00002,ko01000 iYO844.BSU15540 Bacteria 2GKC6@201174,4ERIP@85013,COG0167@1,COG0167@2 NA|NA|NA F Catalyzes the conversion of dihydroorotate to orotate KOPIJCMJ_01701 443218.AS9A_2735 2.6e-40 171.4 Mycobacteriaceae Bacteria 239ZN@1762,2IQ55@201174,COG0640@1,COG0640@2 NA|NA|NA K regulatory protein, arsR KOPIJCMJ_01702 991905.SL003B_1297 6.1e-145 520.8 unclassified Alphaproteobacteria phlC 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1MUZV@1224,2TRHF@28211,4BSJ0@82117,COG0183@1,COG0183@2 NA|NA|NA I acetyl-coa acetyltransferase KOPIJCMJ_01703 991905.SL003B_1298 1.5e-36 159.1 Proteobacteria ko:K07068 ko00000 Bacteria 1RJZS@1224,COG1545@1,COG1545@2 NA|NA|NA S Rubredoxin-like zinc ribbon domain (DUF35_N) KOPIJCMJ_01705 471855.Shel_11220 1.5e-66 260.0 Coriobacteriia pta 2.3.1.8 ko:K00625,ko:K13788 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00230,R00921 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ5U@201174,4CVRI@84998,COG0280@1,COG0280@2 NA|NA|NA C PFAM Phosphate acetyl butaryl transferase KOPIJCMJ_01706 367299.JOEE01000001_gene1505 3.2e-118 432.2 Intrasporangiaceae enhA_2 Bacteria 2GQ7D@201174,4FIVF@85021,COG1376@1,COG1376@2 NA|NA|NA S Putative peptidoglycan binding domain KOPIJCMJ_01707 446470.Snas_0470 1.8e-152 545.8 Glycomycetales bioA 2.6.1.105,2.6.1.62 ko:K00833,ko:K19563 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03231,R10699 RC00006,RC00062,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 iSB619.SA_RS12705 Bacteria 2I2DN@201174,4EY5T@85014,COG0161@1,COG0161@2 NA|NA|NA H Aminotransferase class-III KOPIJCMJ_01708 1223523.H340_07713 2.1e-100 373.6 Actinobacteria Bacteria 2ID4D@201174,COG2124@1,COG2124@2 NA|NA|NA Q Cytochrome P450 KOPIJCMJ_01709 479432.Sros_8310 4.6e-64 251.5 Streptosporangiales bioD GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004141,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017076,GO:0017144,GO:0018130,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.47,6.3.3.3 ko:K00652,ko:K01935 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03182,R03210,R10124 RC00004,RC00039,RC00868,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 2GIZ2@201174,4EIRW@85012,COG0132@1,COG0132@2 NA|NA|NA H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring KOPIJCMJ_01710 1136417.AZWE01000018_gene953 2.4e-144 518.5 Micromonosporales bioB GO:0003674,GO:0003824,GO:0004076,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0017144,GO:0018130,GO:0019752,GO:0030312,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0070283,GO:0071704,GO:0071944,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1589,iZ_1308.Z0994 Bacteria 2GIUE@201174,4D8R0@85008,COG0502@1,COG0502@2 NA|NA|NA H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism KOPIJCMJ_01711 1123024.AUII01000004_gene1673 1e-13 82.4 Pseudonocardiales GO:0002682,GO:0002684,GO:0008150,GO:0009605,GO:0009607,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0075136 Bacteria 2EH0W@1,2GSW1@201174,33ASY@2,4E7W5@85010 NA|NA|NA KOPIJCMJ_01712 1150398.JIBJ01000006_gene3690 1.1e-12 79.3 Actinobacteria Bacteria 2DQ6J@1,2GTCR@201174,334Z3@2 NA|NA|NA S Excalibur calcium-binding domain KOPIJCMJ_01713 1385518.N798_07485 1.3e-10 75.1 Intrasporangiaceae 3.2.1.4 ko:K01179,ko:K11904,ko:K20276 ko00500,ko01100,ko02024,ko03070,map00500,map01100,map02024,map03070 M00334 R06200,R11307,R11308 ko00000,ko00001,ko00002,ko01000,ko02044 3.A.23.1 GH5,GH9 Bacteria 2I7XV@201174,4FK2V@85021,COG4733@1,COG4733@2,COG4932@1,COG4932@2 NA|NA|NA M Fibronectin type III domain KOPIJCMJ_01714 644107.SL1157_0205 1.4e-22 112.8 Ruegeria tolA 4.2.1.1 ko:K01674,ko:K03646 ko00910,map00910 R00132,R10092 RC02807 ko00000,ko00001,ko01000,ko02000 2.C.1.2 Bacteria 1PZDQ@1224,2U2MW@28211,4NBE1@97050,COG3266@1,COG3266@2 NA|NA|NA S Cell division and transport-associated protein TolA KOPIJCMJ_01715 1173264.KI913949_gene3844 2e-29 135.6 Oscillatoriales panE 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2643 Bacteria 1G2H9@1117,1H7Y1@1150,COG1893@1,COG1893@2 NA|NA|NA H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid KOPIJCMJ_01716 479431.Namu_0492 3.7e-101 375.2 Actinobacteria eutG 1.1.1.1,4.3.3.7 ko:K00001,ko:K01714 ko00010,ko00071,ko00261,ko00300,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,ko01230,map00010,map00071,map00261,map00300,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220,map01230 M00016,M00525,M00526,M00527 R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310,R10147 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273,RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 Bacteria 2IDI8@201174,COG1454@1,COG1454@2 NA|NA|NA C Iron-containing alcohol dehydrogenase KOPIJCMJ_01717 479431.Namu_0491 1.3e-30 139.0 Frankiales lsrG 5.3.1.32 ko:K11530 ko02024,map02024 ko00000,ko00001,ko01000 Bacteria 2GSE1@201174,4EX0G@85013,COG1359@1,COG1359@2 NA|NA|NA C Antibiotic biosynthesis monooxygenase KOPIJCMJ_01718 1380354.JIAN01000005_gene1271 8.4e-175 620.9 Cellulomonadaceae 3.6.1.27 ko:K19302 ko00550,map00550 R05627 RC00002 ko00000,ko00001,ko01000,ko01011 Bacteria 2GMAV@201174,4F0KN@85016,COG0392@1,COG0392@2 NA|NA|NA S Lysylphosphatidylglycerol synthase TM region KOPIJCMJ_01719 1304865.JAGF01000001_gene1621 1.8e-309 1068.1 Cellulomonadaceae pfkA 2.7.1.11,2.7.1.90 ko:K00850,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 Bacteria 2GK6W@201174,4F0UZ@85016,COG0205@1,COG0205@2 NA|NA|NA H Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis KOPIJCMJ_01720 644283.Micau_3475 5.2e-25 121.3 Micromonosporales ppaX 3.1.3.18,3.6.1.1 ko:K01091,ko:K06019,ko:K16017 ko00190,ko00630,ko01051,ko01100,ko01110,ko01130,map00190,map00630,map01051,map01100,map01110,map01130 R01334,R06587 RC00017,RC00078 ko00000,ko00001,ko01000 Bacteria 2I9FC@201174,4DFT5@85008,COG0546@1,COG0546@2 NA|NA|NA S HAD-superfamily hydrolase, subfamily IA, variant 3 KOPIJCMJ_01722 1035308.AQYY01000001_gene2967 4.1e-25 120.6 Firmicutes Bacteria 1VCZF@1239,COG2329@1,COG2329@2 NA|NA|NA S Antibiotic biosynthesis monooxygenase KOPIJCMJ_01725 471852.Tcur_2640 1.1e-179 636.3 Streptosporangiales aroH 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJBX@201174,4EGEY@85012,COG3200@1,COG3200@2 NA|NA|NA E Class-II DAHP synthetase family KOPIJCMJ_01726 278957.ABEA03000041_gene2097 1.7e-168 599.0 Opitutae pfp 2.7.1.90 ko:K00895 ko00010,ko00030,ko00051,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map01100,map01110,map01120,map01130 R00764,R02073 RC00017 ko00000,ko00001,ko01000 Bacteria 3K75J@414999,46UQV@74201,COG0205@1,COG0205@2 NA|NA|NA H Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions KOPIJCMJ_01727 1236902.ANAS01000015_gene578 9e-191 673.3 Streptosporangiales glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 Bacteria 2GM13@201174,4EFI5@85012,COG0554@1,COG0554@2 NA|NA|NA C Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate KOPIJCMJ_01728 710696.Intca_1969 8.3e-86 323.6 Intrasporangiaceae plsC 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 2GJ6V@201174,4FEIG@85021,COG0204@1,COG0204@2 NA|NA|NA I 1-acyl-sn-glycerol-3-phosphate acyltransferase KOPIJCMJ_01729 1048339.KB913029_gene4594 6.2e-60 237.7 Frankiales yvaK 3.1.1.1 ko:K03928 ko00000,ko01000 Bacteria 2GM1Y@201174,4ETTX@85013,COG1647@1,COG1647@2 NA|NA|NA S Serine aminopeptidase, S33 KOPIJCMJ_01730 1896.JOAU01000001_gene4484 9e-12 77.4 Actinobacteria Bacteria 2EN8E@1,2GMI1@201174,33FW7@2 NA|NA|NA KOPIJCMJ_01732 1122138.AQUZ01000033_gene3595 1.6e-33 149.1 Propionibacteriales Bacteria 2IFH4@201174,4DRBM@85009,COG2867@1,COG2867@2 NA|NA|NA I Polyketide cyclase / dehydrase and lipid transport KOPIJCMJ_01733 1306174.JODP01000009_gene6550 2e-24 119.4 Actinobacteria Bacteria 2IBDE@201174,COG2197@1,COG2197@2 NA|NA|NA T Two component transcriptional regulator, luxr family KOPIJCMJ_01734 471852.Tcur_2117 1.7e-54 220.3 Streptosporangiales Bacteria 2GN1J@201174,4EJA0@85012,COG5650@1,COG5650@2 NA|NA|NA S Glycosyltransferase family 87 KOPIJCMJ_01735 561175.KB894094_gene1431 1.7e-133 482.6 Streptosporangiales pimB 2.4.1.346,3.2.1.8 ko:K01181,ko:K13668 R11703,R11704 ko00000,ko01000,ko01003 GT4 Bacteria 2GM6D@201174,4EHII@85012,COG0438@1,COG0438@2 NA|NA|NA M Glycosyl transferases group 1 KOPIJCMJ_01736 1048339.KB913029_gene4617 1.1e-11 75.5 Actinobacteria Bacteria 2EGHN@1,2GSZ1@201174,33A9R@2 NA|NA|NA KOPIJCMJ_01737 196162.Noca_3127 6.6e-21 106.3 Actinobacteria Bacteria 2ES7R@1,2IQ6C@201174,33JSG@2 NA|NA|NA KOPIJCMJ_01738 1193181.BN10_360026 3.9e-166 591.7 Intrasporangiaceae cho GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006289,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009380,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016787,GO:0016788,GO:0030312,GO:0031668,GO:0032991,GO:0033554,GO:0033683,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1902494,GO:1905347,GO:1905348,GO:1990391 2.7.7.7 ko:K02342,ko:K03763,ko:K05984 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 2GMC0@201174,4FEF6@85021,COG0322@1,COG0322@2,COG2176@1,COG2176@2 NA|NA|NA L Contains 3'-5'exonuclease domain KOPIJCMJ_01739 1504319.GM45_0755 2.3e-149 535.8 unclassified Actinobacteria (class) petD GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009512,GO:0009579,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0040007,GO:0044424,GO:0044425,GO:0044436,GO:0044459,GO:0044464,GO:0070069,GO:0071944 ko:K00412,ko:K02635,ko:K02637,ko:K03887,ko:K03891,ko:K15879 ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152,M00162 ko00000,ko00001,ko00002,ko00194,ko03029 Bacteria 2GJ1E@201174,3UWCW@52018,COG1290@1,COG1290@2 NA|NA|NA C Cytochrome b/b6/petB KOPIJCMJ_01742 263358.VAB18032_02725 1.4e-79 303.1 Micromonosporales panC GO:0000166,GO:0000287,GO:0001505,GO:0003674,GO:0003824,GO:0004592,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0019482,GO:0019752,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033317,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042133,GO:0042364,GO:0042398,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0065007,GO:0065008,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv3602c Bacteria 2GJEQ@201174,4D99B@85008,COG0414@1,COG0414@2 NA|NA|NA H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate KOPIJCMJ_01743 1123320.KB889585_gene1805 6.6e-98 364.0 Actinobacteria Bacteria 2I2F6@201174,COG5495@1,COG5495@2 NA|NA|NA S Oxidoreductase KOPIJCMJ_01745 1123320.KB889585_gene1795 3.6e-87 328.9 Actinobacteria ko:K08981 ko00000 Bacteria 2GJCD@201174,COG3428@1,COG3428@2 NA|NA|NA S PFAM membrane-flanked domain KOPIJCMJ_01746 1120950.KB892801_gene1727 1.2e-35 156.4 Propionibacteriales ko:K09167 ko00000 Bacteria 2IR88@201174,4DRVV@85009,COG3402@1,COG3402@2 NA|NA|NA S Bacterial PH domain KOPIJCMJ_01747 68260.JOAY01000029_gene3988 9.4e-81 307.4 Actinobacteria nuoD GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 ko:K00333,ko:K05579,ko:K13378 ko00190,ko01100,map00190,map01100 M00144,M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2GKEZ@201174,COG0649@1,COG0649@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient KOPIJCMJ_01748 1121926.AXWO01000013_gene2110 6.9e-07 60.1 Glycomycetales Bacteria 2E8UC@1,2GRUC@201174,3334W@2,4EYXG@85014 NA|NA|NA KOPIJCMJ_01749 1449346.JQMO01000003_gene3784 7.5e-14 84.0 Kitasatospora Bacteria 2DRQG@1,2IFEG@201174,2M38R@2063,33CMQ@2 NA|NA|NA S Protein of unknown function (DUF3180) KOPIJCMJ_01750 1348663.KCH_43430 7e-36 157.1 Kitasatospora folK 2.7.6.3,4.1.2.25 ko:K00950,ko:K13940 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503,R03504 RC00002,RC00017,RC00721,RC00943 ko00000,ko00001,ko00002,ko01000 Bacteria 2H3G6@201174,2M2ED@2063,COG0801@1,COG0801@2 NA|NA|NA H 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) KOPIJCMJ_01751 1343740.M271_27135 1.4e-34 152.5 Actinobacteria folB GO:0008150,GO:0040007 1.13.11.81,2.7.6.3,4.1.2.25,5.1.99.8 ko:K01633,ko:K13940 ko00790,ko01100,map00790,map01100 M00126,M00840 R03503,R03504,R11037,R11073 RC00002,RC00017,RC00721,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 Bacteria 2IHSW@201174,COG1539@1,COG1539@2 NA|NA|NA H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin KOPIJCMJ_01752 590998.Celf_0561 4.2e-89 334.7 Cellulomonadaceae folP 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJDQ@201174,4F0TG@85016,COG0294@1,COG0294@2 NA|NA|NA H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives KOPIJCMJ_01753 743718.Isova_2655 6.1e-82 310.5 Promicromonosporaceae folE GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006082,GO:0006139,GO:0006575,GO:0006725,GO:0006729,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008616,GO:0009058,GO:0009108,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0019752,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042455,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901657,GO:1901659 2.7.6.3,3.5.4.16 ko:K00950,ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R03503,R04639,R05046,R05048 RC00002,RC00017,RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 iIT341.HP0928 Bacteria 2GP2P@201174,4F3XW@85017,COG0302@1,COG0302@2 NA|NA|NA H GTP cyclohydrolase I KOPIJCMJ_01754 1463857.JOFZ01000009_gene6132 6.4e-84 317.4 Actinobacteria ftsH GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019222,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 ko:K03798 M00742 ko00000,ko00002,ko01000,ko01002,ko03110 Bacteria 2GJ4Q@201174,COG0465@1,COG0465@2 NA|NA|NA O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins KOPIJCMJ_01755 479432.Sros_5469 2.3e-16 92.4 Streptosporangiales Bacteria 2GMCG@201174,4EJ36@85012,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family KOPIJCMJ_01756 1123320.KB889676_gene2858 1.7e-209 736.1 Actinobacteria glnD 2.7.7.59 ko:K00990 ko02020,map02020 ko00000,ko00001,ko01000 Bacteria 2GMKT@201174,COG2844@1,COG2844@2 NA|NA|NA O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen KOPIJCMJ_01757 1449353.JQMQ01000005_gene2028 1.7e-46 191.8 Streptacidiphilus glnB ko:K04751 ko02020,map02020 ko00000,ko00001 Bacteria 2IKN1@201174,2NIJK@228398,COG0347@1,COG0347@2 NA|NA|NA E Nitrogen regulatory protein P-II KOPIJCMJ_01758 1306174.JODP01000016_gene7106 1.3e-159 569.7 Actinobacteria amt GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03320 ko00000,ko02000 1.A.11 iNJ661.Rv2920c Bacteria 2GIZK@201174,COG0004@1,COG0004@2 NA|NA|NA P Ammonium transporter KOPIJCMJ_01759 591167.Sfla_1718 1.1e-123 449.9 Actinobacteria ftsY GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 Bacteria 2GJQH@201174,COG0552@1,COG0552@2 NA|NA|NA U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) KOPIJCMJ_01760 1033730.CAHG01000013_gene1327 4.4e-17 93.2 Propionibacteriales smc GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 ko:K03529,ko:K19171 ko00000,ko02048,ko03036 Bacteria 2GK93@201174,4DN2T@85009,COG1196@1,COG1196@2 NA|NA|NA D Required for chromosome condensation and partitioning KOPIJCMJ_01761 710696.Intca_0155 8.2e-60 237.3 Intrasporangiaceae 3.5.1.104 ko:K22278 ko00000,ko01000 Bacteria 2HEQK@201174,4FHJZ@85021,COG0726@1,COG0726@2 NA|NA|NA G Polysaccharide deacetylase KOPIJCMJ_01762 935839.JAGJ01000007_gene3163 1.5e-106 392.5 Promicromonosporaceae gluA 3.6.3.21 ko:K02028,ko:K10008 ko02010,map02010 M00233,M00236 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3,3.A.1.3.9 Bacteria 2GIZW@201174,4F3U5@85017,COG1126@1,COG1126@2 NA|NA|NA E ATPases associated with a variety of cellular activities KOPIJCMJ_01763 1122933.JNIY01000003_gene1070 1.2e-117 429.5 Cellulomonadaceae gluB ko:K10005 ko02010,map02010 M00233 ko00000,ko00001,ko00002,ko02000 3.A.1.3.9 Bacteria 2GJH8@201174,4F1V2@85016,COG0834@1,COG0834@2 NA|NA|NA ET Bacterial periplasmic substrate-binding proteins KOPIJCMJ_01764 1122933.JNIY01000003_gene1069 3.3e-78 298.1 Cellulomonadaceae glnM GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015318,GO:0015711,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1903825,GO:1905039 ko:K10006,ko:K10040 ko02010,map02010 M00228,M00233 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.9 Bacteria 2GNUR@201174,4F2G2@85016,COG0765@1,COG0765@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component KOPIJCMJ_01765 1122933.JNIY01000003_gene1068 5.2e-76 291.2 Cellulomonadaceae gluD ko:K02029,ko:K10007 ko02010,map02010 M00233,M00236 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.9 Bacteria 2GNBH@201174,4F29Z@85016,COG0765@1,COG0765@2 NA|NA|NA E Binding-protein-dependent transport system inner membrane component KOPIJCMJ_01766 67275.JOAP01000018_gene1118 3.4e-18 100.1 Actinobacteria Bacteria 2IBN6@201174,COG1502@1,COG1502@2 NA|NA|NA I PLD-like domain KOPIJCMJ_01768 469383.Cwoe_3710 4.6e-84 318.2 Rubrobacteria Bacteria 2I2PK@201174,4CPE1@84995,COG1215@1,COG1215@2 NA|NA|NA M Glycosyl transferase family 2 KOPIJCMJ_01769 909613.UO65_4713 2.3e-27 129.8 Pseudonocardiales mprF ko:K07027 ko00000,ko02000 4.D.2 Bacteria 2IC25@201174,4E1XV@85010,COG0392@1,COG0392@2 NA|NA|NA S Lysylphosphatidylglycerol synthase TM region KOPIJCMJ_01770 1095767.CAHD01000163_gene3000 5.2e-48 198.0 Actinobacteria Bacteria 2INQ3@201174,COG4122@1,COG4122@2 NA|NA|NA S Methyltransferase domain KOPIJCMJ_01771 1121382.JQKG01000029_gene2690 1.3e-57 229.9 Bacteria 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 Bacteria COG1091@1,COG1091@2 NA|NA|NA M dTDP-4-dehydrorhamnose reductase activity KOPIJCMJ_01772 1172185.KB911513_gene4762 4.7e-48 197.6 Nocardiaceae ko:K21429 ko00000,ko01002 Bacteria 2GKWI@201174,4G7P5@85025,COG4894@1,COG4894@2 NA|NA|NA S LURP-one-related KOPIJCMJ_01773 196162.Noca_0300 1.6e-31 142.1 Propionibacteriales Bacteria 2IKJX@201174,32SQA@2,4DR6N@85009,COG5450@1 NA|NA|NA K Transcription regulator of the Arc MetJ class KOPIJCMJ_01774 263358.VAB18032_21750 1.1e-25 124.4 Actinobacteria Bacteria 2GRFR@201174,COG3409@1,COG3409@2 NA|NA|NA M PFAM Peptidoglycan-binding domain 1 protein KOPIJCMJ_01777 382245.ASA_0486 9e-51 206.8 Aeromonadales maa 2.3.1.79 ko:K00661 ko00000,ko01000 Bacteria 1RA2T@1224,1S3ZZ@1236,1Y4GY@135624,COG0110@1,COG0110@2 NA|NA|NA S Maltose acetyltransferase KOPIJCMJ_01779 105422.BBPM01000049_gene1445 1.2e-68 266.9 Streptacidiphilus apbE 2.7.1.180 ko:K03734 ko00000,ko01000 Bacteria 2H74Y@201174,2NGV9@228398,COG1477@1,COG1477@2 NA|NA|NA H ApbE family KOPIJCMJ_01780 106370.Francci3_2586 1.8e-42 179.5 Frankiales ko:K17247 ko00000 Bacteria 2GQH2@201174,4EW08@85013,COG4097@1,COG4097@2 NA|NA|NA P PFAM Ferric reductase domain protein transmembrane component domain KOPIJCMJ_01781 436229.JOEH01000022_gene682 5.9e-111 407.9 Streptacidiphilus nuoF2 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2GNN9@201174,2NGPM@228398,COG1894@1,COG1894@2 NA|NA|NA C NADH-ubiquinone oxidoreductase-F iron-sulfur binding region KOPIJCMJ_01782 235985.BBPN01000004_gene3111 5.5e-16 89.7 Streptacidiphilus ko:K05337 ko00000 Bacteria 2GSJ7@201174,2NJW1@228398,COG1141@1,COG1141@2 NA|NA|NA C 4Fe-4S single cluster domain KOPIJCMJ_01783 1048339.KB913029_gene2698 4.1e-93 347.8 Frankiales Bacteria 2GIZB@201174,4ERW3@85013,COG0745@1,COG0745@2 NA|NA|NA T response regulator KOPIJCMJ_01784 1003195.SCAT_5254 2.5e-105 389.4 Actinobacteria Bacteria 2GIV9@201174,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor KOPIJCMJ_01785 1121934.AUDX01000004_gene2657 4.8e-36 157.9 Microbacteriaceae Bacteria 2GX8K@201174,4FQPR@85023,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family KOPIJCMJ_01786 1304865.JAGF01000001_gene318 4.3e-172 611.3 Cellulomonadaceae Bacteria 2GIUM@201174,4F1U8@85016,COG0477@1,COG0477@2 NA|NA|NA EGP Transmembrane secretion effector KOPIJCMJ_01787 1348663.KCH_26840 8.9e-38 162.9 Kitasatospora zur GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010043,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0046872,GO:0046914,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 ko:K02076,ko:K03711,ko:K09823 ko02024,map02024 ko00000,ko00001,ko03000 Bacteria 2IKS3@201174,2M2R1@2063,COG0735@1,COG0735@2 NA|NA|NA P Ferric uptake regulator family KOPIJCMJ_01788 1146883.BLASA_1558 1.1e-57 230.3 Frankiales scbA ko:K09815 ko02010,map02010 M00242 ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 Bacteria 2GM1K@201174,4ET8X@85013,COG0803@1,COG0803@2 NA|NA|NA P Belongs to the bacterial solute-binding protein 9 family KOPIJCMJ_01789 935866.JAER01000041_gene3044 1.2e-58 233.4 Propionibacteriales mntB ko:K09817 ko02010,map02010 M00242 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.15.3,3.A.1.15.5 Bacteria 2GP3A@201174,4DPIC@85009,COG1121@1,COG1121@2 NA|NA|NA P ATPases associated with a variety of cellular activities KOPIJCMJ_01790 1237500.ANBA01000009_gene1397 2.5e-67 262.3 Streptosporangiales ko:K09816 ko02010,map02010 M00242 ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 Bacteria 2GJ7H@201174,4EI6R@85012,COG1108@1,COG1108@2 NA|NA|NA P ABC 3 transport family KOPIJCMJ_01791 219305.MCAG_01801 2e-48 199.1 Micromonosporales apl 3.1.3.1 ko:K01077 ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020 M00126 R02135,R04620 RC00017 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 Bacteria 2GN43@201174,4D91R@85008,COG0586@1,COG0586@2 NA|NA|NA S SNARE associated Golgi protein KOPIJCMJ_01792 266940.Krad_4341 1e-138 500.7 Actinobacteria mrcB 2.4.1.129,3.4.16.4 ko:K05365,ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 GT51 Bacteria 2GK21@201174,COG0744@1,COG0744@2 NA|NA|NA M penicillin-binding protein KOPIJCMJ_01793 1122239.AULS01000012_gene1055 1.5e-15 90.9 Microbacteriaceae Bacteria 2GKH8@201174,4FMIF@85023,COG1651@1,COG1651@2 NA|NA|NA O Thioredoxin KOPIJCMJ_01798 675635.Psed_5033 2.5e-144 518.8 Pseudonocardiales ko:K07015 ko00000 Bacteria 2GJTE@201174,4DYC7@85010,COG1215@1,COG1215@2,COG2246@1,COG2246@2 NA|NA|NA M GtrA-like protein KOPIJCMJ_01799 1380356.JNIK01000018_gene799 1e-93 349.7 Frankiales Bacteria 2GIZB@201174,4ERG0@85013,COG0745@1,COG0745@2 NA|NA|NA T Two component transcriptional regulator, winged helix family KOPIJCMJ_01800 1435356.Y013_11045 1.5e-95 357.1 Nocardiaceae phoR 2.7.13.3 ko:K02484,ko:K07768 ko02020,map02020 M00443 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 2I2DU@201174,4FTXC@85025,COG5002@1,COG5002@2 NA|NA|NA T His Kinase A (phosphoacceptor) domain KOPIJCMJ_01801 1394178.AWOO02000024_gene5655 2.1e-27 130.6 Streptosporangiales Bacteria 2HV9N@201174,4EINQ@85012,COG5555@1,COG5555@2 NA|NA|NA N Belongs to the peptidase S8 family KOPIJCMJ_01802 1121946.AUAX01000005_gene5163 8.1e-59 234.6 Micromonosporales Bacteria 2GIR7@201174,4D95J@85008,COG4129@1,COG4129@2 NA|NA|NA S Evidence 4 Homologs of previously reported genes of KOPIJCMJ_01803 479431.Namu_0355 9.7e-10 68.2 Actinobacteria Bacteria 2EGTM@1,2GWY1@201174,33AJR@2 NA|NA|NA KOPIJCMJ_01804 446465.Bfae_27530 7.6e-79 301.2 Dermabacteraceae yqhO GO:0003674,GO:0003824,GO:0016787 ko:K07001 ko00000 Bacteria 2IA6V@201174,4FC03@85020,COG1752@1,COG1752@2 NA|NA|NA S Patatin-like phospholipase KOPIJCMJ_01805 1304865.JAGF01000001_gene3499 2.2e-102 379.0 Actinobacteria corA ko:K03284 ko00000,ko02000 1.A.35.1,1.A.35.3 Bacteria 2IB0N@201174,COG0598@1,COG0598@2 NA|NA|NA P PFAM Mg2 transporter protein CorA family protein KOPIJCMJ_01806 1463903.JOIZ01000010_gene3653 1.1e-52 213.4 Actinobacteria Bacteria 2GJ2N@201174,COG0745@1,COG0745@2 NA|NA|NA T response regulator, receiver KOPIJCMJ_01807 219305.MCAG_00090 1.1e-46 194.5 Micromonosporales Bacteria 2GJKC@201174,4DHA1@85008,COG0642@1,COG2205@2 NA|NA|NA T Domain of unknown function (DUF4118) KOPIJCMJ_01808 219305.MCAG_00089 5.3e-201 707.6 Micromonosporales ydaO Bacteria 2GK5V@201174,4DI99@85008,COG0531@1,COG0531@2 NA|NA|NA E Amino acid permease KOPIJCMJ_01809 1150399.AQYK01000001_gene352 3.3e-54 218.4 Microbacteriaceae yfbT GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0030145,GO:0042578,GO:0043136,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050084,GO:0050286,GO:0050308,GO:0050897 3.1.3.23 ko:K19270 ko00000,ko01000 Bacteria 2GNX0@201174,4FPH8@85023,COG0637@1,COG0637@2 NA|NA|NA V Haloacid dehalogenase-like hydrolase KOPIJCMJ_01810 1172188.KB911822_gene720 8.1e-50 203.4 Intrasporangiaceae ko:K09763 ko00000 Bacteria 2IHUS@201174,4FH6W@85021,COG1547@1,COG1547@2 NA|NA|NA S Domain of unknown function (DUF309) KOPIJCMJ_01812 1227261.HMPREF0043_00810 3.9e-07 60.8 Actinobacteria Bacteria 2GITW@201174,4D39J@85005,COG1167@1,COG1167@2 NA|NA|NA EK Aminotransferase, class I II KOPIJCMJ_01814 1035308.AQYY01000001_gene3069 3.8e-124 451.8 Clostridia hemG 1.3.3.15,1.3.3.4 ko:K00231 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03222,R04178 RC00885 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQ6W@1239,24IHQ@186801,COG1232@1,COG1232@2 NA|NA|NA H Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX KOPIJCMJ_01815 446471.Xcel_3125 2.6e-136 491.9 Actinobacteria pqqE ko:K22227 ko00000 Bacteria 2GNSY@201174,COG0535@1,COG0535@2 NA|NA|NA C Radical SAM KOPIJCMJ_01816 266940.Krad_1273 2e-10 72.0 Actinobacteria Bacteria 2E3JG@1,2GU6T@201174,32YHV@2 NA|NA|NA KOPIJCMJ_01817 479435.Kfla_5917 5.5e-144 517.7 Propionibacteriales yjcD GO:0003674,GO:0005215,GO:0005345,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006863,GO:0008150,GO:0015205,GO:0015208,GO:0015851,GO:0015854,GO:0016020,GO:0022857,GO:0035344,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:0098657,GO:0098710,GO:0098739,GO:1903716,GO:1904823 ko:K06901 ko00000,ko02000 2.A.1.40 Bacteria 2GKYD@201174,4DNIA@85009,COG2252@1,COG2252@2 NA|NA|NA S Permease family KOPIJCMJ_01819 408672.NBCG_02347 5.8e-27 127.9 Propionibacteriales rpoC Bacteria 2GKXN@201174,4DQPK@85009,COG0739@1,COG0739@2 NA|NA|NA M PFAM NLP P60 protein KOPIJCMJ_01820 1123393.KB891317_gene2319 8.2e-68 263.5 Betaproteobacteria yiiE Bacteria 1R9WQ@1224,2VQBM@28216,COG3548@1,COG3548@2 NA|NA|NA S Protein of unknown function (DUF1211) KOPIJCMJ_01821 665577.JH993790_gene1709 4.3e-14 85.5 Actinobacteria Bacteria 2B5F3@1,2H0EX@201174,31Y9K@2 NA|NA|NA S Short C-terminal domain KOPIJCMJ_01822 1379270.AUXF01000001_gene2074 1.4e-41 176.8 Gemmatimonadetes Bacteria 1ZTNA@142182,2ZA6T@2,arCOG10456@1 NA|NA|NA KOPIJCMJ_01823 931626.Awo_c04330 1.9e-14 85.9 Eubacteriaceae Bacteria 1TTZ1@1239,25HYR@186801,25XUE@186806,COG1846@1,COG1846@2 NA|NA|NA K Transcriptional regulator KOPIJCMJ_01824 1386089.N865_17375 1.8e-82 313.2 Intrasporangiaceae ko:K06889 ko00000 Bacteria 2I0E5@201174,4FJN1@85021,COG1073@1,COG1073@2 NA|NA|NA S X-Pro dipeptidyl-peptidase (S15 family) KOPIJCMJ_01825 1254432.SCE1572_09945 3.6e-71 276.6 Myxococcales Bacteria 1QX82@1224,2X86M@28221,2Z3M6@29,43CYG@68525,COG5555@1,COG5555@2 NA|NA|NA N FG-GAP repeat KOPIJCMJ_01826 512565.AMIS_47840 1.6e-48 199.5 Bacteria 2.7.1.48 ko:K00876 ko00240,ko00983,ko01100,map00240,map00983,map01100 R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232 RC00002,RC00017 ko00000,ko00001,ko01000 Bacteria COG0572@1,COG0572@2 NA|NA|NA F uridine kinase KOPIJCMJ_01827 1192034.CAP_8770 4.7e-24 117.5 Myxococcales Bacteria 1NKMZ@1224,2WX3E@28221,2YXMJ@29,431JR@68525,COG5646@1,COG5646@2 NA|NA|NA S Domain of unknown function (DU1801) KOPIJCMJ_01828 234621.RER_10530 1.9e-46 193.0 Nocardiaceae Bacteria 2GIX7@201174,4G094@85025,COG5002@1,COG5002@2 NA|NA|NA T His Kinase A (phosphoacceptor) domain KOPIJCMJ_01829 1240349.ANGC01000011_gene329 4.8e-78 297.7 Nocardiaceae Bacteria 2GK5S@201174,4G8SS@85025,COG0745@1,COG0745@2 NA|NA|NA K Transcriptional regulatory protein, C terminal KOPIJCMJ_01831 223184.AS25_05575 2.5e-142 512.3 Micrococcaceae Bacteria 1W8P3@1268,2GMJ4@201174,COG2132@1,COG2132@2 NA|NA|NA Q Multicopper oxidase KOPIJCMJ_01835 1157943.KB892705_gene3044 4.7e-51 208.4 Bacteria cof Bacteria COG0561@1,COG0561@2 NA|NA|NA Q phosphatase activity KOPIJCMJ_01836 1171373.PACID_04150 3.3e-08 64.3 Propionibacteriales ko:K00375 ko00000,ko03000 Bacteria 2GITW@201174,4DPHM@85009,COG1167@1,COG1167@2 NA|NA|NA K helix_turn_helix gluconate operon transcriptional repressor KOPIJCMJ_01838 1150399.AQYK01000002_gene2758 1.5e-38 166.0 Microbacteriaceae yaeJ ko:K02835,ko:K15034 ko00000,ko03012 Bacteria 2I7Z4@201174,4FPEN@85023,COG0216@1,COG0216@2 NA|NA|NA J RF-1 domain KOPIJCMJ_01839 266940.Krad_1202 8.2e-08 64.3 Bacteria ko:K15383 ko00000,ko02000 9.A.58.2 Bacteria COG4095@1,COG4095@2 NA|NA|NA S Sugar efflux transporter for intercellular exchange KOPIJCMJ_01840 1033730.CAHG01000004_gene3 2.2e-59 235.3 Propionibacteriales adk 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GJ7T@201174,4DP2T@85009,COG0563@1,COG0563@2 NA|NA|NA F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism KOPIJCMJ_01841 1510531.JQJJ01000008_gene4215 3.4e-156 558.5 Bradyrhizobiaceae ybaL GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03455 ko00000 2.A.37 Bacteria 1MV34@1224,2TRC5@28211,3JVBN@41294,COG1226@1,COG1226@2,COG4651@1,COG4651@2 NA|NA|NA P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family KOPIJCMJ_01843 1429046.RR21198_0487 9.6e-74 284.3 Nocardiaceae gcd Bacteria 2GISM@201174,4FYBJ@85025,COG2133@1,COG2133@2 NA|NA|NA G Glucose / Sorbosone dehydrogenase KOPIJCMJ_01844 2045.KR76_01335 5.4e-56 224.2 Propionibacteriales ko:K03088 ko00000,ko03021 Bacteria 2GJUI@201174,4DR64@85009,COG1595@1,COG1595@2 NA|NA|NA K Sigma-70 region 2 KOPIJCMJ_01845 477641.MODMU_2499 2.6e-18 98.6 Frankiales Bacteria 2E61P@1,2II66@201174,330QX@2,4ETM0@85013 NA|NA|NA KOPIJCMJ_01846 110319.CF8_3504 8e-119 434.1 Propionibacteriales 3.4.21.62 ko:K01342 ko02024,map02024 ko00000,ko00001,ko01000,ko01002,ko03110 Bacteria 2GNIX@201174,4DPVM@85009,COG1404@1,COG1404@2 NA|NA|NA O peptidase S8 and S53, subtilisin, kexin, sedolisin KOPIJCMJ_01848 298653.Franean1_0312 4.5e-23 114.0 Frankiales rsbV GO:0003674,GO:0005488,GO:0005515,GO:0042802 ko:K04749 ko00000,ko03021 Bacteria 2IHQG@201174,4ESTZ@85013,COG1366@1,COG1366@2 NA|NA|NA T Belongs to the anti-sigma-factor antagonist family KOPIJCMJ_01849 397278.JOJN01000002_gene505 1.5e-227 796.2 Propionibacteriales yprA GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 ko:K06877 ko00000 Bacteria 2GJJ6@201174,4DNQG@85009,COG1205@1,COG1205@2 NA|NA|NA L Domain of unknown function (DUF1998) KOPIJCMJ_01851 28444.JODQ01000014_gene6780 1.2e-11 76.3 Streptosporangiales GO:0008150,GO:0010941,GO:0033668,GO:0035821,GO:0042981,GO:0043067,GO:0043069,GO:0044003,GO:0044068,GO:0044403,GO:0044419,GO:0044531,GO:0044532,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051701,GO:0051704,GO:0051817,GO:0052040,GO:0052041,GO:0052150,GO:0052248,GO:0052433,GO:0052490,GO:0060548,GO:0065007 Bacteria 2EGB2@1,2GWPQ@201174,33A2X@2,4EKNC@85012 NA|NA|NA KOPIJCMJ_01853 2002.JOEQ01000043_gene5988 5.7e-26 124.8 Streptosporangiales gspF ko:K12510,ko:K12511 ko00000,ko02044 Bacteria 2IQE9@201174,4EJVY@85012,COG2064@1,COG2064@2 NA|NA|NA NU Type II secretion system (T2SS), protein F KOPIJCMJ_01854 1449069.JMLO01000008_gene3545 8.6e-19 101.3 Nocardiaceae Bacteria 2IAVM@201174,4G8K9@85025,COG0596@1,COG0596@2 NA|NA|NA S Alpha/beta hydrolase family KOPIJCMJ_01856 1306174.JODP01000015_gene3952 1.8e-148 532.7 Actinobacteria Bacteria 2IBIG@201174,COG0477@1,COG0477@2 NA|NA|NA EGP Major facilitator superfamily KOPIJCMJ_01857 208439.AJAP_30840 1.2e-28 134.4 Pseudonocardiales Bacteria 2H2HE@201174,4E9WQ@85010,COG2199@1,COG3706@2 NA|NA|NA T diguanylate cyclase KOPIJCMJ_01858 1120949.KB903317_gene1657 6.1e-54 218.8 Micromonosporales ko:K14645 ko02024,map02024 ko00000,ko00001,ko01000,ko01002,ko03110 Bacteria 2GIRE@201174,4DAEM@85008,COG1404@1,COG1404@2 NA|NA|NA O Belongs to the peptidase S8 family KOPIJCMJ_01859 1033730.CAHG01000006_gene1155 6.4e-19 99.8 Propionibacteriales ko:K07213 ko04978,map04978 ko00000,ko00001 Bacteria 2GQK5@201174,4DSND@85009,COG2608@1,COG2608@2 NA|NA|NA P Heavy-metal-associated domain KOPIJCMJ_01860 1440053.JOEI01000024_gene1194 4e-99 368.6 Actinobacteria dinF GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03327 ko00000,ko02000 2.A.66.1 Bacteria 2GJE3@201174,COG0534@1,COG0534@2 NA|NA|NA V MATE efflux family protein KOPIJCMJ_01861 479433.Caci_0301 2.8e-21 107.5 Actinobacteria bldC Bacteria 2GQJ9@201174,COG2452@1,COG2452@2 NA|NA|NA L TIGRFAM DNA binding domain protein, excisionase family KOPIJCMJ_01862 1121272.KB903261_gene6014 2e-08 64.7 Micromonosporales Bacteria 2EGRW@1,2IQF3@201174,33AI2@2,4DFQ7@85008 NA|NA|NA S Protein of unknown function (DUF3073) KOPIJCMJ_01863 1288083.AUKR01000017_gene2494 1.1e-129 469.9 Actinobacteria purM GO:0003674,GO:0003824,GO:0004641,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.1,6.3.4.13 ko:K01933,ko:K11788 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144,R04208 RC00090,RC00166,RC01100 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1844,iECSF_1327.ECSF_2340 Bacteria 2GJNY@201174,COG0150@1,COG0150@2 NA|NA|NA F Phosphoribosylformylglycinamidine cyclo-ligase KOPIJCMJ_01864 479432.Sros_8991 3.1e-47 194.5 Streptosporangiales purF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009507,GO:0009536,GO:0040007,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 Bacteria 2GK6I@201174,4EGDA@85012,COG0034@1,COG0034@2 NA|NA|NA F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine KOPIJCMJ_01865 1146883.BLASA_2088 2.8e-136 492.3 Frankiales sucB 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GMUV@201174,4ERCG@85013,COG0508@1,COG0508@2 NA|NA|NA C TIGRFAM 2-oxoglutarate dehydrogenase, E2 component KOPIJCMJ_01866 1169154.KB897783_gene4646 2e-102 379.0 Actinobacteria GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006066,GO:0006629,GO:0006706,GO:0006707,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008395,GO:0009056,GO:0016020,GO:0016042,GO:0016125,GO:0016127,GO:0016491,GO:0016705,GO:0016709,GO:0020037,GO:0030312,GO:0031073,GO:0036199,GO:0044238,GO:0044281,GO:0044282,GO:0044464,GO:0046164,GO:0046906,GO:0048037,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1901615,GO:1901616,GO:1902652 ko:K07071 ko00000 Bacteria 2GJS0@201174,COG1090@1,COG1090@2 NA|NA|NA S epimerase KOPIJCMJ_01868 1464048.JNZS01000006_gene4063 3.4e-72 278.1 Micromonosporales lipB GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0033819,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0071944,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.3.1.181 ko:K03801 ko00785,ko01100,map00785,map01100 R07766,R07769 RC00039,RC00992,RC02867 ko00000,ko00001,ko01000 Bacteria 2GJIX@201174,4DADI@85008,COG0321@1,COG0321@2 NA|NA|NA H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate KOPIJCMJ_01869 1077974.GOEFS_009_00220 2.4e-135 488.4 Gordoniaceae lipA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 R07767,R07768 RC01978 ko00000,ko00001,ko01000 Bacteria 2GKD4@201174,4GBJ4@85026,COG0320@1,COG0320@2 NA|NA|NA H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives KOPIJCMJ_01870 1123319.AUBE01000003_gene975 1.6e-51 209.5 Actinobacteria GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 Bacteria 2AUFS@1,2GIXC@201174,31K3Y@2 NA|NA|NA S Domain of unknown function (DUF4191) KOPIJCMJ_01871 479433.Caci_6340 7.8e-93 347.4 Actinobacteria Bacteria 2GIRA@201174,COG4977@1,COG4977@2 NA|NA|NA K Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain KOPIJCMJ_01873 1121017.AUFG01000001_gene2901 5.5e-27 127.5 Intrasporangiaceae Bacteria 2IQMG@201174,4FHT2@85021,COG1714@1,COG1714@2 NA|NA|NA S PFAM RDD domain containing protein KOPIJCMJ_01874 1157943.KB892705_gene2163 1.5e-62 245.7 Mycobacteriaceae istB Bacteria 234SX@1762,2H714@201174,COG1484@1,COG1484@2 NA|NA|NA L IstB-like ATP binding protein KOPIJCMJ_01876 861360.AARI_08090 1.3e-46 193.0 Actinobacteria pin GO:0000150,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140097,GO:1901360 Bacteria 2HSUX@201174,COG1961@1,COG1961@2 NA|NA|NA L Site-specific recombinases, DNA invertase Pin homologs KOPIJCMJ_01877 557599.MKAN_09615 1.3e-93 350.5 Mycobacteriaceae Bacteria 235TY@1762,2GKU0@201174,COG1020@1,COG1020@2 NA|NA|NA Q Diacylglycerol O-acyltransferase KOPIJCMJ_01878 471852.Tcur_2109 3.9e-51 208.0 Streptosporangiales ruvC GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 ko:K01159 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 2GJI5@201174,4EIKP@85012,COG0817@1,COG0817@2 NA|NA|NA L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group KOPIJCMJ_01879 1120950.KB892708_gene4274 1.4e-51 209.5 Propionibacteriales ruvA GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 ko:K03550 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 2GN17@201174,4DQ7Y@85009,COG0632@1,COG0632@2 NA|NA|NA L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB KOPIJCMJ_01880 570268.ANBB01000054_gene4590 1.1e-139 503.1 Streptosporangiales ruvB GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 3.6.4.12 ko:K03551 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 2GJZF@201174,4EH70@85012,COG2255@1,COG2255@2 NA|NA|NA L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing KOPIJCMJ_01881 1504319.GM45_5165 3e-115 422.5 unclassified Actinobacteria (class) secD GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 Bacteria 2GJTT@201174,3UWKE@52018,COG0342@1,COG0342@2 NA|NA|NA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA KOPIJCMJ_01882 1123322.KB904647_gene1647 3.9e-93 348.6 Actinobacteria secF GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 ko:K03072,ko:K03074,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 Bacteria 2GJRS@201174,COG0341@1,COG0341@2 NA|NA|NA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA KOPIJCMJ_01883 351607.Acel_1338 1.7e-299 1035.0 Frankiales relA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009259,GO:0009260,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0015969,GO:0015970,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034035,GO:0034036,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042578,GO:0042594,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044419,GO:0044464,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051704,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 Bacteria 2GJYQ@201174,4EREV@85013,COG0317@1,COG0317@2 NA|NA|NA KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance KOPIJCMJ_01884 1894.JOER01000023_gene7347 8.7e-88 330.9 Actinobacteria Bacteria 2GJBD@201174,COG1196@1,COG1196@2 NA|NA|NA D Domain of Unknown Function (DUF349) KOPIJCMJ_01885 1504319.GM45_5185 3.1e-54 218.8 unclassified Actinobacteria (class) 5.2.1.8 ko:K01802,ko:K03768 ko00000,ko01000,ko03110 Bacteria 2GN8G@201174,3UWKX@52018,COG0652@1,COG0652@2 NA|NA|NA O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides KOPIJCMJ_01886 935866.JAER01000015_gene1674 7.2e-76 290.4 Propionibacteriales ycbL 3.1.2.6 ko:K01069 ko00620,map00620 R01736 RC00004,RC00137 ko00000,ko00001,ko01000 Bacteria 2GJU0@201174,4DNMS@85009,COG0491@1,COG0491@2 NA|NA|NA S Metallo-beta-lactamase superfamily KOPIJCMJ_01888 1463856.JOHY01000007_gene716 1.5e-67 262.7 Actinobacteria orn GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360 ko:K13288 ko03008,map03008 ko00000,ko00001,ko01000,ko03009,ko03019 Bacteria 2GJR7@201174,COG1949@1,COG1949@2 NA|NA|NA L 3'-to-5' exoribonuclease specific for small oligoribonucleotides KOPIJCMJ_01889 404589.Anae109_2437 7.9e-13 80.5 Myxococcales ko:K04767,ko:K07168,ko:K07182 ko00000 Bacteria 1N0EB@1224,2WRIB@28221,2YVSI@29,42W96@68525,COG0517@1,COG0517@2 NA|NA|NA S CBS domain KOPIJCMJ_01890 1125863.JAFN01000001_gene2799 8.3e-35 153.3 Deltaproteobacteria tesC GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0047617,GO:0055114,GO:0071704,GO:0072329,GO:1901575 ko:K07107,ko:K12500 ko00000,ko01000,ko01004 Bacteria 1REIH@1224,2WQAZ@28221,42UZ3@68525,COG0824@1,COG0824@2 NA|NA|NA S Thioesterase-like superfamily KOPIJCMJ_01891 2002.JOEQ01000005_gene3672 7.5e-185 654.1 Streptosporangiales Bacteria 2I3HX@201174,4EHKS@85012,COG0421@1,COG0421@2 NA|NA|NA E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine KOPIJCMJ_01892 1237500.ANBA01000033_gene4471 2.1e-144 519.2 Streptosporangiales ada 3.2.2.21 ko:K13529,ko:K15051 ko03410,map03410 ko00000,ko00001,ko01000,ko03000,ko03400 Bacteria 2GITG@201174,4EGE3@85012,COG0122@1,COG0122@2,COG2169@1,COG2169@2 NA|NA|NA FL AlkA N-terminal domain KOPIJCMJ_01893 1192759.AKIB01000096_gene1609 1.8e-38 166.0 Sphingomonadales ogt 1.17.99.6,2.1.1.63 ko:K00567,ko:K18979 ko00000,ko01000,ko03016,ko03400 Bacteria 1N2YQ@1224,2KD23@204457,2TRRN@28211,COG0350@1,COG0350@2 NA|NA|NA L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated KOPIJCMJ_01895 1121017.AUFG01000013_gene1927 6.9e-188 664.1 Intrasporangiaceae feoB ko:K04759 ko00000,ko02000 9.A.8.1 Bacteria 2GTV2@201174,4FIUH@85021,COG0370@1,COG0370@2 NA|NA|NA P Ferrous iron transport protein B C terminus KOPIJCMJ_01897 1278078.G419_04718 2.1e-36 159.1 Nocardiaceae Bacteria 2GJPU@201174,4FTWD@85025,COG1807@1,COG1807@2 NA|NA|NA M Dolichyl-phosphate-mannose-protein mannosyltransferase KOPIJCMJ_01899 1304865.JAGF01000001_gene1014 2.6e-46 192.2 Actinobacteria kcsA ko:K10716 ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 Bacteria 2GKNF@201174,COG1226@1,COG1226@2 NA|NA|NA P Ion transport 2 domain protein KOPIJCMJ_01902 1050202.KB913024_gene55 2.7e-116 425.6 Actinopolysporales Bacteria 2GKGM@201174,407NC@622450,COG2733@1,COG2733@2 NA|NA|NA S Protein of unknown function (DUF445) KOPIJCMJ_01903 1032480.MLP_00530 3.9e-107 395.2 Propionibacteriales pit ko:K03306 ko00000 2.A.20 Bacteria 2GJHK@201174,4DND5@85009,COG0306@1,COG0306@2 NA|NA|NA P Phosphate transporter family KOPIJCMJ_01904 101510.RHA1_ro03323 2.2e-90 338.6 Nocardiaceae Bacteria 2GMSB@201174,4FXCP@85025,COG2013@1,COG2013@2 NA|NA|NA T Mitochondrial biogenesis AIM24 KOPIJCMJ_01905 1120950.KB892759_gene6277 2.4e-77 296.2 Propionibacteriales Bacteria 2I2J0@201174,4DQBJ@85009,COG2385@1,COG2385@2 NA|NA|NA D PFAM Stage II sporulation D domain protein KOPIJCMJ_01906 1229780.BN381_100067 3.7e-60 238.4 unclassified Actinobacteria (class) hrtA 3.6.3.25 ko:K02003,ko:K06020,ko:K09810,ko:K09814 ko02010,map02010 M00255,M00257,M00258 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.125 Bacteria 2GNB3@201174,3UXF5@52018,COG1136@1,COG1136@2 NA|NA|NA V ATPases associated with a variety of cellular activities KOPIJCMJ_01907 1313172.YM304_38290 1.5e-38 167.2 Actinobacteria ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GMC4@201174,COG0577@1,COG0577@2 NA|NA|NA V ABC-type antimicrobial peptide transport system, permease component KOPIJCMJ_01908 1229780.BN381_100069 3.5e-32 146.0 Bacteria ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria COG0577@1,COG0577@2 NA|NA|NA V efflux transmembrane transporter activity KOPIJCMJ_01909 1120949.KB903328_gene8960 7.2e-09 68.6 Micromonosporales Bacteria 2DMZ3@1,2IQMH@201174,32UHB@2,4DFK7@85008 NA|NA|NA S Predicted membrane protein (DUF2157) KOPIJCMJ_01910 479432.Sros_8729 6.3e-148 530.8 Streptosporangiales nplT 3.2.1.1 ko:K01176 ko00500,ko01100,ko04973,map00500,map01100,map04973 R02108,R02112,R11262 ko00000,ko00001,ko01000 GH13 Bacteria 2GJUT@201174,4EIF5@85012,COG0366@1,COG0366@2 NA|NA|NA G Alpha amylase, catalytic domain KOPIJCMJ_01911 768671.ThimaDRAFT_1447 2.9e-79 302.8 Chromatiales ggt 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 Bacteria 1MUV6@1224,1SMH6@1236,1X0JB@135613,COG0405@1,COG0405@2 NA|NA|NA E Gamma-glutamyltranspeptidase KOPIJCMJ_01912 497321.C664_13322 2.8e-81 308.1 Rhodocyclales pfpI 3.5.1.124 ko:K05520 ko00000,ko01000,ko01002 Bacteria 1MY0C@1224,2KV2H@206389,2VM0T@28216,COG0693@1,COG0693@2 NA|NA|NA S DJ-1/PfpI family KOPIJCMJ_01913 103733.JNYO01000021_gene6755 5.8e-30 138.7 Actinobacteria Bacteria 2H3FK@201174,COG2199@1,COG3706@2,COG5001@1,COG5001@2 NA|NA|NA T diguanylate cyclase KOPIJCMJ_01914 420324.KI912044_gene3963 8.2e-28 131.0 Methylobacteriaceae ko:K06889 ko00000 Bacteria 1JTW5@119045,1NXZW@1224,2TSEE@28211,COG1073@1,COG1073@2 NA|NA|NA S Uncharacterised protein family (UPF0227) KOPIJCMJ_01915 1894.JOER01000022_gene3926 3.6e-96 359.0 Actinobacteria 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 Bacteria 2GKPZ@201174,COG0154@1,COG0154@2 NA|NA|NA J Belongs to the amidase family KOPIJCMJ_01916 935866.JAER01000027_gene4225 1.5e-41 176.0 Propionibacteriales Bacteria 2IME3@201174,4DWV7@85009,COG2716@1,COG2716@2 NA|NA|NA E ACT domain KOPIJCMJ_01918 526225.Gobs_4775 8.9e-64 250.8 Frankiales rsgA 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 Bacteria 2GMDX@201174,4EU3D@85013,COG1162@1,COG1162@2 NA|NA|NA S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit KOPIJCMJ_01919 1032480.MLP_14960 1.7e-67 262.3 Propionibacteriales def 3.5.1.88 ko:K01462 ko00000,ko01000 Bacteria 2GJ87@201174,4DQAV@85009,COG0242@1,COG0242@2 NA|NA|NA J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions KOPIJCMJ_01920 867903.ThesuDRAFT_01213 7.3e-126 457.6 Clostridiales incertae sedis fumC 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 Bacteria 1UHPH@1239,25F3I@186801,3WCCI@538999,COG0114@1,COG0114@2 NA|NA|NA C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate KOPIJCMJ_01922 67352.JODS01000001_gene448 2.1e-105 389.0 Actinobacteria yeaC ko:K03924 ko00000,ko01000 Bacteria 2GK07@201174,COG0714@1,COG0714@2 NA|NA|NA S associated with various cellular activities KOPIJCMJ_01923 994479.GL877879_gene5041 1.3e-67 262.7 Pseudonocardiales Bacteria 2GN4R@201174,4DZ99@85010,COG2030@1,COG2030@2 NA|NA|NA I MaoC like domain KOPIJCMJ_01924 1504319.GM45_1075 2.9e-43 181.4 unclassified Actinobacteria (class) mraZ GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0040007,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 ko:K03925 ko00000 Bacteria 2IHUB@201174,3UWSJ@52018,COG2001@1,COG2001@2 NA|NA|NA K MraZ protein, putative antitoxin-like KOPIJCMJ_01926 65497.JODV01000002_gene4329 2.2e-107 395.6 Pseudonocardiales rsmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 ko:K03438 ko00000,ko01000,ko03009 Bacteria 2GJGK@201174,4DZ61@85010,COG0275@1,COG0275@2 NA|NA|NA M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA KOPIJCMJ_01927 479435.Kfla_2879 3.4e-14 85.9 Propionibacteriales ftsL ko:K05589,ko:K12065 ko00000,ko02044,ko03036 3.A.7.11.1 Bacteria 2GW5Q@201174,4DS2Z@85009,COG2919@1,COG2919@2 NA|NA|NA D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic KOPIJCMJ_01928 1504319.GM45_1090 4.1e-139 501.9 unclassified Actinobacteria (class) ftsI GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008144,GO:0008150,GO:0008658,GO:0008955,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0031224,GO:0031226,GO:0031406,GO:0032153,GO:0033218,GO:0033293,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:1901363,GO:1901681 3.4.16.4 ko:K03587,ko:K08384,ko:K08724,ko:K12552,ko:K12556 ko00550,ko01100,ko01501,map00550,map01100,map01501 ko00000,ko00001,ko01000,ko01011,ko03036 iSSON_1240.SSON_0092 Bacteria 2GKHH@201174,3UWG5@52018,COG0768@1,COG0768@2 NA|NA|NA M Penicillin-binding Protein dimerisation domain KOPIJCMJ_01929 1120950.KB892707_gene4885 5.2e-143 514.6 Propionibacteriales murE GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.10,6.3.2.13 ko:K01928,ko:K15792 ko00300,ko00550,map00300,map00550 R02788,R04617 RC00064,RC00090,RC00141 ko00000,ko00001,ko01000,ko01011 iNJ661.Rv2158c Bacteria 2GIS2@201174,4DN64@85009,COG0769@1,COG0769@2 NA|NA|NA M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan KOPIJCMJ_01930 146922.JOFU01000006_gene2820 3.6e-135 488.4 Actinobacteria murF 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 Bacteria 2GK0Y@201174,COG0770@1,COG0770@2 NA|NA|NA M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein KOPIJCMJ_01931 1504319.GM45_1105 4.5e-117 427.9 unclassified Actinobacteria (class) mraY GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 iAF987.Gmet_0409,iEC042_1314.EC042_0088,iECABU_c1320.ECABU_c00920,iECED1_1282.ECED1_0088,iECH74115_1262.ECH74115_0095,iECSP_1301.ECSP_0090,iECs_1301.ECs0091,iG2583_1286.G2583_0091,iSDY_1059.SDY_0117,iZ_1308.Z0097,ic_1306.c0105 Bacteria 2GNEH@201174,3UWA7@52018,COG0472@1,COG0472@2 NA|NA|NA M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan KOPIJCMJ_01932 1048339.KB913029_gene4578 1.3e-148 533.1 Frankiales murD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 iNJ661.Rv2155c Bacteria 2GJZA@201174,4ERI0@85013,COG0771@1,COG0771@2 NA|NA|NA M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) KOPIJCMJ_01933 1120950.KB892707_gene4889 2.9e-91 342.4 Propionibacteriales ftsW GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008360,GO:0009987,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032153,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051179,GO:0051234,GO:0051301,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:1901264,GO:1901505 2.4.1.227 ko:K02563,ko:K03588 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011,ko02000,ko03036 2.A.103.1 GT28 Bacteria 2GKXP@201174,4DNHR@85009,COG0772@1,COG0772@2 NA|NA|NA D Belongs to the SEDS family KOPIJCMJ_01934 1288083.AUKR01000001_gene1241 6.3e-119 434.1 Actinobacteria murG 2.4.1.227,6.3.2.8 ko:K01924,ko:K02563 ko00471,ko00550,ko01100,ko01502,ko04112,map00471,map00550,map01100,map01502,map04112 R03193,R05032,R05662 RC00005,RC00049,RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 GT28 iLJ478.TM0232 Bacteria 2GJEM@201174,COG0707@1,COG0707@2 NA|NA|NA M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) KOPIJCMJ_01935 1048339.KB913029_gene4575 4.7e-138 498.0 Frankiales murC GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 Bacteria 2I2E7@201174,4ERUC@85013,COG0773@1,COG0773@2 NA|NA|NA M Belongs to the MurCDEF family KOPIJCMJ_01936 446462.Amir_5761 3.2e-24 119.0 Pseudonocardiales ftsQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944 6.3.2.4 ko:K01921,ko:K03589,ko:K06438 ko00473,ko00550,ko01100,ko01502,ko04112,map00473,map00550,map01100,map01502,map04112 R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011,ko03036 Bacteria 2H4A4@201174,4E3DB@85010,COG1589@1,COG1589@2 NA|NA|NA D Cell division protein FtsQ KOPIJCMJ_01937 68223.JNZY01000002_gene5187 1e-154 553.1 Actinobacteria ftsZ GO:0000166,GO:0000287,GO:0000910,GO:0000921,GO:0000935,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022402,GO:0022607,GO:0030428,GO:0031106,GO:0032153,GO:0032155,GO:0032185,GO:0032506,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0045787,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051258,GO:0051301,GO:0051726,GO:0065003,GO:0065007,GO:0070925,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:1901265,GO:1901363 ko:K03531 ko04112,map04112 ko00000,ko00001,ko02048,ko03036,ko04812 Bacteria 2GJWC@201174,COG0206@1,COG0206@2 NA|NA|NA D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity KOPIJCMJ_01938 882083.SacmaDRAFT_3694 1.9e-48 199.5 Pseudonocardiales yfiH GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016679,GO:0016682,GO:0030312,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0046983,GO:0055114,GO:0071944 ko:K05810 ko00000,ko01000 Bacteria 2GN1M@201174,4DZFD@85010,COG1496@1,COG1496@2 NA|NA|NA S Belongs to the multicopper oxidase YfiH RL5 family KOPIJCMJ_01939 58123.JOFJ01000001_gene3034 4.1e-66 258.1 Streptosporangiales yggS GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 ko:K06997 ko00000 Bacteria 2GMRJ@201174,4EGGM@85012,COG0325@1,COG0325@2 NA|NA|NA S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis KOPIJCMJ_01940 1122611.KB903978_gene3351 7.6e-41 173.7 Streptosporangiales sepF GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0007049,GO:0008150,GO:0009987,GO:0016043,GO:0022402,GO:0022607,GO:0032506,GO:0042802,GO:0044085,GO:0051301,GO:0071840,GO:0090529 ko:K09772 ko00000,ko03036 Bacteria 2GNVH@201174,4EIJC@85012,COG1799@1,COG1799@2 NA|NA|NA D Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA KOPIJCMJ_01941 1184609.KILIM_034_00410 1e-15 89.4 Dermatophilaceae yggT GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02221 ko00000,ko02044 Bacteria 2GQI1@201174,4F798@85018,COG0762@1,COG0762@2 NA|NA|NA S YGGT family KOPIJCMJ_01942 1452536.JARE01000050_gene1860 1.7e-09 69.3 Microbacteriaceae wag31 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008360,GO:0009273,GO:0009987,GO:0016020,GO:0022603,GO:0022604,GO:0030312,GO:0031647,GO:0040007,GO:0042546,GO:0044085,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0050821,GO:0051128,GO:0060187,GO:0065007,GO:0065008,GO:0071554,GO:0071840,GO:0071944 Bacteria 2GMSC@201174,4FNCA@85023,COG3599@1,COG3599@2 NA|NA|NA D DivIVA protein KOPIJCMJ_01943 935866.JAER01000007_gene424 1.7e-41 177.2 Propionibacteriales Bacteria 2AUNZ@1,2GP4I@201174,31KBW@2,4DRN6@85009 NA|NA|NA S Protein of unknown function (DUF2786) KOPIJCMJ_01944 1123322.KB904652_gene570 0.0 1502.3 Actinobacteria ileS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iG2583_1286.G2583_0027,iPC815.YPO0475 Bacteria 2GK9M@201174,COG0060@1,COG0060@2 NA|NA|NA J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) KOPIJCMJ_01945 471857.Svir_27290 1.9e-12 78.6 Pseudonocardiales MA20_25230 ko:K09131 ko00000 Bacteria 2GQSC@201174,4E6KR@85010,COG1872@1,COG1872@2 NA|NA|NA EGP Belongs to the UPF0235 family KOPIJCMJ_01946 1116232.AHBF01000005_gene1545 2.5e-35 155.2 Actinobacteria dksA ko:K06204 ko02026,map02026 ko00000,ko00001,ko03000,ko03009,ko03021 Bacteria 2GJBE@201174,COG1734@1,COG1734@2 NA|NA|NA T Transcriptional regulator, TraR DksA family KOPIJCMJ_01947 298653.Franean1_5087 3.2e-36 158.3 Frankiales lspA 3.4.23.36 ko:K03101 ko03060,map03060 ko00000,ko00001,ko01000,ko01002 Bacteria 2GKRX@201174,4ET0T@85013,COG0597@1,COG0597@2 NA|NA|NA MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins KOPIJCMJ_01948 1121017.AUFG01000014_gene2014 1.8e-114 419.1 Intrasporangiaceae rluD GO:0000027,GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022607,GO:0022613,GO:0022618,GO:0031118,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 5.4.99.23,5.4.99.28,5.4.99.29 ko:K06177,ko:K06180 ko00000,ko01000,ko03009,ko03016 iE2348C_1286.E2348C_2868,iECED1_1282.ECED1_3035,iECSF_1327.ECSF_2432 Bacteria 2GIY1@201174,4FFFW@85021,COG0564@1,COG0564@2 NA|NA|NA J Responsible for synthesis of pseudouridine from uracil KOPIJCMJ_01949 471852.Tcur_0033 4e-103 381.3 Streptosporangiales ydbC 1.1.1.65 ko:K05275 ko00750,ko01100,ko01120,map00750,map01100,map01120 R01708 RC00116 ko00000,ko00001,ko01000 Bacteria 2GJ6R@201174,4EICB@85012,COG0667@1,COG0667@2 NA|NA|NA C Aldo/keto reductase family KOPIJCMJ_01950 483219.LILAB_07875 3e-176 625.2 Myxococcales fhs GO:0000096,GO:0000097,GO:0000105,GO:0003674,GO:0003824,GO:0004329,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006144,GO:0006520,GO:0006547,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009108,GO:0009110,GO:0009112,GO:0009113,GO:0009256,GO:0009257,GO:0009396,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0016874,GO:0016879,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0052803,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.5.1.5,3.5.4.9,6.3.4.3 ko:K00288,ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00141,M00377 R00943,R01220,R01655 RC00026,RC00111,RC00202,RC00578 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1MUR8@1224,2WJF1@28221,2YZGJ@29,42MKE@68525,COG2759@1,COG2759@2 NA|NA|NA F Belongs to the formate--tetrahydrofolate ligase family KOPIJCMJ_01951 526225.Gobs_3245 7.3e-119 433.7 Frankiales dnaE 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 2GJ1P@201174,4ERD2@85013,COG0587@1,COG0587@2 NA|NA|NA L DNA polymerase III alpha subunit KOPIJCMJ_01952 1054860.KB913030_gene4805 1.8e-07 62.8 Bacteria Bacteria 2ECFJ@1,336DU@2 NA|NA|NA S Peptidase inhibitor family I36 KOPIJCMJ_01954 1184609.KILIM_005_00630 4.1e-142 511.1 Actinobacteria tniA ko:K07497 ko00000 Bacteria 2IPDN@201174,COG2801@1,COG2801@2 NA|NA|NA L Mu transposase, C-terminal KOPIJCMJ_01955 1184609.KILIM_005_00620 5.6e-116 424.1 Bacteria clpB ko:K03695 ko04213,map04213 ko00000,ko00001,ko03110 Bacteria COG0542@1,COG0542@2 NA|NA|NA O response to heat KOPIJCMJ_01956 266264.Rmet_3008 9.3e-87 327.4 Burkholderiaceae tniQ Bacteria 1K4K9@119060,1PE75@1224,2C5W7@1,2VM9N@28216,2Z8WC@2 NA|NA|NA S TniQ KOPIJCMJ_01957 1454004.AW11_02902 1e-84 319.7 Betaproteobacteria tniR Bacteria 1MXXT@1224,2VJ32@28216,COG1961@1,COG1961@2 NA|NA|NA L Resolvase, N terminal domain KOPIJCMJ_01960 1449346.JQMO01000003_gene5623 1.1e-59 237.7 Kitasatospora 2.7.13.3 ko:K07778 ko02020,map02020 M00479 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 2GKJJ@201174,2M2QI@2063,COG3463@1,COG3463@2 NA|NA|NA S Predicted membrane protein (DUF2079) KOPIJCMJ_01961 479431.Namu_3045 7.3e-196 690.3 Actinobacteria Bacteria 2GM4J@201174,COG4584@1,COG4584@2 NA|NA|NA L Transposase KOPIJCMJ_01962 246196.MSMEI_1676 3.9e-27 127.5 Mycobacteriaceae ko:K07483 ko00000 Bacteria 23988@1762,2IHPH@201174,COG2963@1,COG2963@2 NA|NA|NA L Transposase KOPIJCMJ_01963 1048339.KB913029_gene295 5.2e-55 220.7 Frankiales ko:K07497 ko00000 Bacteria 2GKDY@201174,4ESNN@85013,COG2801@1,COG2801@2 NA|NA|NA L PFAM Integrase catalytic region KOPIJCMJ_01964 1229780.BN381_600011 9.1e-230 802.7 Actinobacteria ltrA Bacteria 2GUJS@201174,COG3344@1,COG3344@2 NA|NA|NA L RNA-directed DNA polymerase (reverse transcriptase) KOPIJCMJ_01965 1048339.KB913029_gene295 4.5e-68 264.6 Frankiales ko:K07497 ko00000 Bacteria 2GKDY@201174,4ESNN@85013,COG2801@1,COG2801@2 NA|NA|NA L PFAM Integrase catalytic region KOPIJCMJ_01966 1184607.AUCHE_05_04270 0.0 1230.3 Actinobacteria nifJ GO:0003674,GO:0003824,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016491,GO:0016625,GO:0016903,GO:0043873,GO:0050896,GO:0055114 1.18.1.2,1.19.1.1,1.2.7.1,1.2.7.3,1.3.7.1 ko:K00176,ko:K00528,ko:K03737,ko:K20449 ko00010,ko00020,ko00620,ko00650,ko00720,ko00760,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map00760,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00307,M00620 R01196,R01197,R03164,R10159,R10866 RC00004,RC02422,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 iJN678.nifJ,iLF82_1304.LF82_2789,iNRG857_1313.NRG857_06920 Bacteria 2I995@201174,COG0674@1,COG0674@2,COG1013@1,COG1013@2,COG1014@1,COG1014@2,COG1149@1,COG1149@2 NA|NA|NA C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin KOPIJCMJ_01967 395965.Msil_2988 1.2e-84 320.1 Beijerinckiaceae 1.3.98.1 ko:K00226 ko00240,ko01100,map00240,map01100 M00051 R01867 RC00051 ko00000,ko00001,ko00002,ko01000 Bacteria 1MXER@1224,2V9AU@28211,3NBTI@45404,COG0167@1,COG0167@2 NA|NA|NA F Dihydroorotate dehydrogenase KOPIJCMJ_01968 196162.Noca_2569 1.9e-07 62.4 Propionibacteriales Bacteria 2EGIC@1,2I19N@201174,33AAH@2,4DSK8@85009 NA|NA|NA S Protein of unknown function (DUF3099) KOPIJCMJ_01969 935866.JAER01000002_gene1853 7.9e-26 122.5 Propionibacteriales ko:K09165 ko00000 Bacteria 2IQ6Z@201174,4DS6C@85009,COG3360@1,COG3360@2 NA|NA|NA S Dodecin KOPIJCMJ_01970 67281.JNZZ01000018_gene544 2.5e-104 386.0 Streptomyces griseus group tldD3 Bacteria 2GZPS@201174,419X8@629295,COG0312@1,COG0312@2 NA|NA|NA S Putative modulator of DNA gyrase KOPIJCMJ_01971 105420.BBPO01000035_gene472 7e-56 223.4 Streptacidiphilus tldD ko:K03568 ko00000,ko01002 Bacteria 2GJ4E@201174,2NHWB@228398,COG0312@1,COG0312@2 NA|NA|NA S Modulator of DNA gyrase KOPIJCMJ_01972 345341.KUTG_02431 2.1e-128 466.1 Pseudonocardiales Bacteria 2HNS8@201174,4EA2Q@85010,COG2152@1,COG2152@2 NA|NA|NA G beta-1,4-mannooligosaccharide phosphorylase KOPIJCMJ_01973 345341.KUTG_02430 6.9e-32 143.7 Actinobacteria Bacteria 2I5YD@201174,COG1331@1,COG1331@2 NA|NA|NA O Highly conserved protein containing a thioredoxin domain KOPIJCMJ_01974 710696.Intca_3045 6.7e-98 364.8 Intrasporangiaceae Bacteria 2GNPG@201174,4FJ4K@85021,COG0438@1,COG0438@2 NA|NA|NA M Glycosyl transferase KOPIJCMJ_01975 1121272.KB903290_gene4457 7.7e-09 65.5 Micromonosporales Bacteria 2EI4A@1,2GX45@201174,33BVN@2,4DGEI@85008 NA|NA|NA KOPIJCMJ_01977 390989.JOEG01000003_gene4476 7.8e-50 204.5 Micromonosporales Bacteria 2HSM4@201174,4DFKR@85008,COG1295@1,COG1295@2 NA|NA|NA S Virulence factor BrkB KOPIJCMJ_01979 2045.KR76_01350 2.1e-80 306.2 Propionibacteriales Bacteria 2GKCX@201174,4DPXK@85009,COG0457@1,COG0457@2,COG4995@1,COG4995@2 NA|NA|NA K CHAT domain KOPIJCMJ_01980 285535.JOEY01000001_gene5229 3.2e-59 235.0 Actinobacteria Bacteria 2GVM5@201174,COG1309@1,COG1309@2 NA|NA|NA K transcriptional regulator KOPIJCMJ_01981 477641.MODMU_4652 2.5e-14 84.3 Frankiales Bacteria 2E3M2@1,2GQQW@201174,32YJA@2,4ETF4@85013 NA|NA|NA S Protein of unknown function (DUF3107) KOPIJCMJ_01982 452652.KSE_48740 2.5e-60 238.8 Kitasatospora GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0071771 1.16.3.1,4.1.99.5 ko:K03594,ko:K14331 ko00860,map00860 R00078 RC02758 ko00000,ko00001,ko01000 Bacteria 2I2E1@201174,2M2BB@2063,COG1633@1,COG1633@2 NA|NA|NA S tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like KOPIJCMJ_01983 1439940.BAY1663_04768 9.1e-09 67.0 Proteobacteria Bacteria 1P17G@1224,2EQQB@1,33IA8@2 NA|NA|NA KOPIJCMJ_01985 110319.CF8_3589 9e-67 261.5 Propionibacteriales Bacteria 2ICM5@201174,4DQ8D@85009,COG4421@1,COG4421@2 NA|NA|NA G Protein of unknown function (DUF563) KOPIJCMJ_01986 479431.Namu_0418 1.9e-88 332.8 Frankiales Bacteria 2GIS3@201174,4EU7J@85013,COG0604@1,COG0604@2 NA|NA|NA C alcohol dehydrogenase KOPIJCMJ_01987 1385519.N801_00245 1.2e-63 250.0 Intrasporangiaceae Bacteria 2DBV7@1,2IGRZ@201174,2ZB9P@2,4FHPC@85021 NA|NA|NA S Domain of unknown function (DUF4386) KOPIJCMJ_01988 1304865.JAGF01000001_gene432 8e-18 96.3 Actinobacteria Bacteria 2DBV7@1,2IGRZ@201174,2ZB9P@2 NA|NA|NA S Domain of unknown function (DUF4386) KOPIJCMJ_01989 1172188.KB911822_gene696 3.1e-242 845.1 Intrasporangiaceae ko:K03556 ko00000,ko03000 Bacteria 2HEX2@201174,4FF31@85021,COG2909@1,COG2909@2 NA|NA|NA K helix_turn_helix, Lux Regulon KOPIJCMJ_01990 479431.Namu_0429 1.8e-99 369.4 Frankiales 1.8.1.9 ko:K00384 ko00450,map00450 R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 Bacteria 2GIXN@201174,4ESGA@85013,COG0492@1,COG0492@2 NA|NA|NA O Pyridine nucleotide-disulphide oxidoreductase KOPIJCMJ_01991 1032480.MLP_34390 2.1e-44 185.3 Propionibacteriales adk 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2I45A@201174,4DSTH@85009,COG0563@1,COG0563@2 NA|NA|NA F AAA domain KOPIJCMJ_01993 1171373.PACID_21720 3.8e-27 127.5 Actinobacteria Bacteria 2GXCS@201174,COG2361@1,COG2361@2 NA|NA|NA S Protein of unknown function DUF86 KOPIJCMJ_01994 1035308.AQYY01000001_gene2076 1.3e-44 186.0 Bacteria ko:K07075 ko00000 Bacteria COG1669@1,COG1669@2 NA|NA|NA S nucleotidyltransferase activity KOPIJCMJ_01995 1089455.MOPEL_010_00010 4.9e-185 654.1 Dermatophilaceae Bacteria 2H68X@201174,4F7DH@85018,COG3385@1,COG3385@2 NA|NA|NA L Transposase DDE domain group 1 KOPIJCMJ_01997 1321778.HMPREF1982_01855 1e-59 237.3 Clostridia 2.7.1.15,2.7.1.187,2.7.1.45 ko:K00852,ko:K00874,ko:K19978 ko00030,ko00525,ko01100,ko01120,ko01130,ko01200,map00030,map00525,map01100,map01120,map01130,map01200 M00061,M00308,M00631 R01051,R01541,R02750,R11184 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 1TRRQ@1239,24D41@186801,COG0524@1,COG0524@2 NA|NA|NA G pfkB family carbohydrate kinase KOPIJCMJ_01998 446470.Snas_3927 5.7e-19 101.3 Glycomycetales Bacteria 2GQRD@201174,4EZTI@85014,COG1309@1,COG1309@2 NA|NA|NA K Tetracyclin repressor, C-terminal all-alpha domain KOPIJCMJ_02000 1386089.N865_05300 2.3e-24 119.4 Actinobacteria Bacteria 2BFB8@1,2ISHF@201174,32949@2 NA|NA|NA KOPIJCMJ_02002 471853.Bcav_3697 1e-70 273.9 Actinobacteria Bacteria 2GIS3@201174,COG0604@1,COG0604@2 NA|NA|NA C alcohol dehydrogenase KOPIJCMJ_02003 1206737.BAGF01000151_gene6270 2.4e-72 279.3 Nocardiaceae Bacteria 2GIS3@201174,4FYN0@85025,COG0604@1,COG0604@2 NA|NA|NA C Zinc-binding dehydrogenase KOPIJCMJ_02004 1123023.JIAI01000029_gene4468 3.1e-64 252.3 Actinobacteria ko:K03321 ko00000,ko02000 2.A.53.3 Bacteria 2H1V9@201174,COG0659@1,COG0659@2 NA|NA|NA P Molybdate transporter of MFS superfamily KOPIJCMJ_02005 1043205.AFYF01000045_gene2925 2.7e-08 65.9 Intrasporangiaceae Bacteria 2ET1V@1,2GZYR@201174,33KK0@2,4FI7B@85021 NA|NA|NA S Protein of unknown function (DUF2975) KOPIJCMJ_02006 35754.JNYJ01000011_gene741 2.5e-22 111.3 Micromonosporales yozG ko:K07727 ko00000,ko03000 Bacteria 2GQZM@201174,4DEY7@85008,COG3655@1,COG3655@2 NA|NA|NA K Cro/C1-type HTH DNA-binding domain KOPIJCMJ_02007 1121019.AUMN01000003_gene1021 5.8e-52 210.3 Actinobacteria vapC ko:K07062 ko00000,ko01000,ko02048 Bacteria 2IS29@201174,COG1487@1,COG1487@2 NA|NA|NA S Toxic component of a toxin-antitoxin (TA) module. An RNase KOPIJCMJ_02008 1108045.GORHZ_171_00530 2e-22 111.3 Actinobacteria ko:K21495 ko00000,ko02048 Bacteria 2GSHN@201174,COG4691@1,COG4691@2 NA|NA|NA S Plasmid stability protein KOPIJCMJ_02009 1171373.PACID_01380 2.3e-32 144.8 Actinobacteria ko:K07075 ko00000 Bacteria 2IT4H@201174,COG1669@1,COG1669@2 NA|NA|NA S Nucleotidyltransferase domain KOPIJCMJ_02011 1206732.BAGD01000097_gene4238 5.9e-45 188.0 Nocardiaceae Bacteria 2IMKC@201174,4G03M@85025,COG2021@1,COG2021@2 NA|NA|NA E Serine aminopeptidase, S33 KOPIJCMJ_02012 1385520.N802_11490 1.4e-25 122.5 Intrasporangiaceae Bacteria 2E8MQ@1,2ISX4@201174,332Z5@2,4FHDD@85021 NA|NA|NA S Ribbon-helix-helix protein, copG family KOPIJCMJ_02013 1146883.BLASA_1416 5.7e-35 153.3 Actinobacteria mazF5 GO:0008150,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0065007 ko:K07171 ko00000,ko01000,ko02048 Bacteria 2IMGQ@201174,COG2337@1,COG2337@2 NA|NA|NA T Evidence 2b Function of strongly homologous gene KOPIJCMJ_02014 477641.MODMU_1575 1.2e-18 98.6 Actinobacteria GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007 Bacteria 2FDS3@1,2GUMT@201174,345T0@2 NA|NA|NA S Evidence 4 Homologs of previously reported genes of KOPIJCMJ_02015 1380386.JIAW01000031_gene3544 1.3e-19 102.1 Actinobacteria Bacteria 2HD6A@201174,COG2002@1,COG2002@2 NA|NA|NA K toxin-antitoxin pair type II binding KOPIJCMJ_02016 1121019.AUMN01000033_gene2670 3.7e-42 177.6 Actinobacteria Bacteria 2GPFR@201174,COG4374@1,COG4374@2 NA|NA|NA S PIN domain KOPIJCMJ_02017 1906.SFRA_16750 5.7e-57 226.9 Actinobacteria arsC 1.20.4.1 ko:K03741 ko00000,ko01000 Bacteria 2IHR3@201174,COG0394@1,COG0394@2 NA|NA|NA T Belongs to the low molecular weight phosphotyrosine protein phosphatase family KOPIJCMJ_02018 1177594.MIC448_940017 1.8e-18 98.6 Microbacteriaceae glpF 1.20.4.1 ko:K02440,ko:K03741,ko:K06188 ko00000,ko01000,ko02000 1.A.8,1.A.8.1,1.A.8.2 Bacteria 2GMG4@201174,4FNDY@85023,COG0580@1,COG0580@2 NA|NA|NA G Major intrinsic protein KOPIJCMJ_02020 479435.Kfla_3707 8.1e-70 270.8 Propionibacteriales cphB GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0042802,GO:0042803,GO:0043170,GO:0044238,GO:0046983,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.15.6 ko:K13282 R09722 RC00064,RC00141 ko00000,ko01000,ko01002 iJN678.slr2001 Bacteria 2I93U@201174,4DP1Z@85009,COG4242@1,COG4242@2 NA|NA|NA PQ Peptidase family S51 KOPIJCMJ_02021 43759.JNWK01000070_gene4557 2.7e-35 155.2 Actinobacteria sixA ko:K08296 ko00000,ko01000 Bacteria 2GJ0I@201174,COG2062@1,COG2062@2 NA|NA|NA T phosphohistidine phosphatase, SixA KOPIJCMJ_02022 313589.JNB_03230 2.5e-97 362.5 Intrasporangiaceae serB GO:0003674,GO:0003824,GO:0004647,GO:0004721,GO:0004722,GO:0005488,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016597,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0031406,GO:0036094,GO:0036211,GO:0040007,GO:0042578,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564 3.1.3.3 ko:K01079 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R00582 RC00017 ko00000,ko00001,ko00002,ko01000,ko01009 iNJ661.Rv3042c Bacteria 2GJDH@201174,4FFIF@85021,COG0560@1,COG0560@2,COG3830@1,COG3830@2 NA|NA|NA E phosphoserine phosphatase KOPIJCMJ_02023 1121924.ATWH01000005_gene2551 1.6e-25 121.7 Actinobacteria Bacteria 2BAGM@1,2H8NG@201174,323X7@2 NA|NA|NA KOPIJCMJ_02024 1137268.AZXF01000040_gene3328 6.9e-22 109.8 Bacteria ko:K06218 ko00000,ko02048 Bacteria COG2026@1,COG2026@2 NA|NA|NA DJ nuclease activity KOPIJCMJ_02025 710696.Intca_0789 2.3e-139 502.3 Intrasporangiaceae Bacteria 2GS79@201174,4FFP0@85021,COG3547@1,COG3547@2 NA|NA|NA L Transposase KOPIJCMJ_02028 457425.XNR_2969 2.2e-81 310.5 Actinobacteria Bacteria 2GNFI@201174,COG0583@1,COG0583@2 NA|NA|NA K DNA-binding transcription factor activity KOPIJCMJ_02029 101510.RHA1_ro11282 2e-120 439.1 Nocardiaceae Bacteria 2GKXH@201174,4G1SK@85025,COG2842@1,COG2842@2 NA|NA|NA S AAA domain KOPIJCMJ_02030 101510.RHA1_ro11283 1e-189 670.2 Nocardiaceae ko:K07497 ko00000 Bacteria 2HITH@201174,4FZG5@85025,COG2801@1,COG2801@2 NA|NA|NA L Transposition protein KOPIJCMJ_02031 101510.RHA1_ro11284 7.5e-63 247.3 Actinobacteria Bacteria 2BSDG@1,2I51E@201174,32MFF@2 NA|NA|NA S Evidence 4 Homologs of previously reported genes of KOPIJCMJ_02032 1123320.KB889730_gene6044 1.5e-189 669.1 Actinobacteria dnaB GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0030312,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 ko00000,ko00001,ko01000,ko03032 Bacteria 2GKXQ@201174,COG0305@1,COG0305@2 NA|NA|NA L Participates in initiation and elongation during chromosome replication KOPIJCMJ_02033 1463853.JOHW01000024_gene4633 6.6e-33 147.1 Actinobacteria ptpA 3.1.3.48 ko:K01104 ko00000,ko01000 Bacteria 2IM0Q@201174,COG0394@1,COG0394@2 NA|NA|NA T Belongs to the low molecular weight phosphotyrosine protein phosphatase family KOPIJCMJ_02034 1122237.AUGQ01000001_gene1157 2.9e-12 77.8 Microbacteriaceae Bacteria 28XBN@1,2GY64@201174,2ZJ9I@2,4FQM1@85023 NA|NA|NA KOPIJCMJ_02035 1194165.CAJF01000021_gene3051 2.3e-112 411.8 Microbacteriaceae yplQ ko:K11068 ko00000,ko02042 Bacteria 2GJGQ@201174,4FK4N@85023,COG1272@1,COG1272@2 NA|NA|NA S Haemolysin-III related KOPIJCMJ_02036 1194165.CAJF01000021_gene3050 5.5e-108 397.1 Microbacteriaceae uppS1 GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617 2.5.1.31,2.5.1.68 ko:K00806,ko:K12503 ko00900,ko01110,map00900,map01110 R06447,R08528 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 Bacteria 2GJCP@201174,4FKY2@85023,COG0020@1,COG0020@2 NA|NA|NA I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids KOPIJCMJ_02037 1120950.KB892823_gene569 4.6e-196 690.6 Propionibacteriales phoH ko:K07175 ko00000 Bacteria 2GK8U@201174,4DNRD@85009,COG1875@1,COG1875@2 NA|NA|NA T phosphate starvation-inducible protein PhoH KOPIJCMJ_02038 1122239.AULS01000021_gene2490 9.9e-18 97.4 Actinobacteria ko:K21471 ko00000,ko01000,ko01002,ko01011 Bacteria 2I5D4@201174,COG3206@1,COG3206@2 NA|NA|NA M NLP P60 protein KOPIJCMJ_02039 926550.CLDAP_40500 5.8e-62 244.6 Chloroflexi Bacteria 2G6KN@200795,COG2220@1,COG2220@2 NA|NA|NA S Belongs to the UPF0173 family KOPIJCMJ_02041 405948.SACE_2041 9.9e-255 885.9 Pseudonocardiales aspS GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 Bacteria 2GJHU@201174,4E0SI@85010,COG0173@1,COG0173@2 NA|NA|NA J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) KOPIJCMJ_02042 1033730.CAHG01000016_gene574 3.1e-163 581.6 Propionibacteriales hisS 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 2GIYJ@201174,4DP1N@85009,COG0124@1,COG0124@2 NA|NA|NA J Histidine--tRNA ligase KOPIJCMJ_02043 1121926.AXWO01000007_gene138 2.6e-14 84.0 Glycomycetales groS GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 ko:K04078 ko00000,ko03029,ko03110 Bacteria 2IHRC@201174,4EYVB@85014,COG0234@1,COG0234@2 NA|NA|NA O Chaperonin 10 Kd subunit KOPIJCMJ_02045 1380354.JIAN01000005_gene2705 0.0 1346.3 Cellulomonadaceae lysS GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iAF1260.b4129,iECDH1ME8569_1439.ECDH1ME8569_3989,iECW_1372.ECW_m4490,iEcDH1_1363.EcDH1_3862,iJN678.lysS,iJO1366.b4129,iWFL_1372.ECW_m4490 Bacteria 2GKE0@201174,4F1Q9@85016,COG1190@1,COG1190@2,COG2898@1,COG2898@2 NA|NA|NA J Uncharacterised conserved protein (DUF2156) KOPIJCMJ_02048 2045.KR76_02335 1.7e-25 124.8 Propionibacteriales Bacteria 2HQ5S@201174,4DS25@85009,COG4585@1,COG4585@2 NA|NA|NA T Histidine kinase-like ATPases KOPIJCMJ_02049 1123377.AUIV01000016_gene295 1.6e-56 227.6 Gammaproteobacteria Bacteria 1R7HC@1224,1T5UV@1236,COG2199@1,COG2202@1,COG2202@2,COG3706@2 NA|NA|NA T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) KOPIJCMJ_02050 1120949.KB903294_gene4303 3e-192 678.3 Micromonosporales ko:K03321 ko00000,ko02000 2.A.53.3 Bacteria 2GJCB@201174,4D9U7@85008,COG0659@1,COG0659@2 NA|NA|NA P Sulfate permease family KOPIJCMJ_02052 543632.JOJL01000050_gene7408 3.2e-31 144.4 Micromonosporales ko:K20276 ko02024,map02024 ko00000,ko00001 Bacteria 2H7QD@201174,4DJZF@85008,COG3170@1,COG3170@2,COG4733@1,COG4733@2 NA|NA|NA NU Fibronectin type III domain KOPIJCMJ_02053 710696.Intca_0817 2e-107 396.0 Intrasporangiaceae ko:K04088 M00742 ko00000,ko00002,ko01000 Bacteria 2GJ8Q@201174,4FESN@85021,COG0053@1,COG0053@2 NA|NA|NA P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family KOPIJCMJ_02054 543632.JOJL01000023_gene1726 3e-30 138.3 Micromonosporales Bacteria 2IJFQ@201174,32SB1@2,4DE0Y@85008,COG1145@1 NA|NA|NA C Ferredoxin KOPIJCMJ_02055 1121372.AULK01000001_gene1951 4.8e-98 364.4 Microbacteriaceae uppP 3.6.1.27 ko:K06153 ko00550,map00550 R05627 RC00002 ko00000,ko00001,ko01000,ko01011 Bacteria 2GJVG@201174,4FKPS@85023,COG1968@1,COG1968@2 NA|NA|NA V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin KOPIJCMJ_02056 397945.Aave_2022 2.2e-307 1061.6 Comamonadaceae treS GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016310,GO:0034637,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046835,GO:0071704,GO:0071944,GO:1901576 2.4.1.18,2.7.1.175,3.2.1.1,5.4.99.16 ko:K00700,ko:K05343,ko:K16146 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01557,R02108,R02110,R02112,R09945,R11262 RC00002,RC00078,RC01816 ko00000,ko00001,ko00002,ko01000,ko04147 CBM48,GH13 Bacteria 1MVKX@1224,2VHW5@28216,4ABG1@80864,COG0366@1,COG0366@2,COG3281@1,COG3281@2 NA|NA|NA G SMART alpha amylase catalytic sub domain KOPIJCMJ_02058 1095767.CAHD01000191_gene271 1.2e-168 600.1 Cellulomonadaceae malZ GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0004558,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009311,GO:0009313,GO:0009987,GO:0015926,GO:0016052,GO:0016787,GO:0016798,GO:0030978,GO:0030980,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044464,GO:0051691,GO:0051692,GO:0071704,GO:0090599,GO:1901575 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 GH31 iECH74115_1262.ECH74115_0480,iEcSMS35_1347.EcSMS35_0434,iSFV_1184.SFV_0368,iYL1228.KPN_00344 Bacteria 2GJUT@201174,4F26G@85016,COG0366@1,COG0366@2 NA|NA|NA G Alpha-amylase domain KOPIJCMJ_02059 479431.Namu_4684 5.3e-122 444.1 Actinobacteria malG GO:0003674,GO:0003824,GO:0005215,GO:0005363,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015154,GO:0015157,GO:0015399,GO:0015405,GO:0015422,GO:0015423,GO:0015766,GO:0015768,GO:0015772,GO:0015774,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033037,GO:0034219,GO:0042623,GO:0042626,GO:0042956,GO:0043190,GO:0043211,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990060,GO:1990351 ko:K10110,ko:K15772 ko02010,map02010 M00194,M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1.1,3.A.1.1.16,3.A.1.1.2,3.A.1.1.22 iLJ478.TM1202,iSSON_1240.SSON_4210,iYL1228.KPN_04421 Bacteria 2I2EZ@201174,COG3833@1,COG3833@2 NA|NA|NA P PFAM binding-protein-dependent transport systems inner membrane component KOPIJCMJ_02060 479431.Namu_4685 2.8e-208 731.5 Actinobacteria malF GO:0003674,GO:0003824,GO:0005215,GO:0005363,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006950,GO:0006974,GO:0008150,GO:0008643,GO:0009987,GO:0015144,GO:0015154,GO:0015157,GO:0015399,GO:0015405,GO:0015422,GO:0015423,GO:0015766,GO:0015768,GO:0015772,GO:0015774,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033037,GO:0033554,GO:0034219,GO:0042623,GO:0042626,GO:0042956,GO:0043190,GO:0043211,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990060,GO:1990351 ko:K02025,ko:K10109,ko:K10118,ko:K10233,ko:K15771 ko02010,map02010 M00194,M00196,M00201,M00207,M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.1,3.A.1.1.16,3.A.1.1.2,3.A.1.1.22,3.A.1.1.28,3.A.1.1.32,3.A.1.1.8 iZ_1308.Z5631 Bacteria 2GJGB@201174,COG1175@1,COG1175@2 NA|NA|NA G PFAM binding-protein-dependent transport systems inner membrane component KOPIJCMJ_02061 479431.Namu_4686 1.1e-125 456.8 Bacteria ko:K02027,ko:K15770 ko02010,map02010 M00207,M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.2 Bacteria COG2182@1,COG2182@2 NA|NA|NA G maltose binding KOPIJCMJ_02062 1001240.GY21_16135 1.2e-52 214.2 Microbacteriaceae ko:K02027,ko:K15770 ko02010,map02010 M00207,M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.2 Bacteria 2HSEH@201174,4FMZA@85023,COG2182@1,COG2182@2 NA|NA|NA G Bacterial extracellular solute-binding protein KOPIJCMJ_02063 1961.JOAK01000011_gene5882 1.4e-37 162.2 Actinobacteria glnB ko:K04751 ko02020,map02020 ko00000,ko00001 Bacteria 2IKN1@201174,COG0347@1,COG0347@2 NA|NA|NA K Belongs to the P(II) protein family KOPIJCMJ_02064 1120950.KB892769_gene5401 1.3e-142 513.1 Propionibacteriales amt GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03320 ko00000,ko02000 1.A.11 iNJ661.Rv2920c Bacteria 2GIZK@201174,4DNW9@85009,COG0004@1,COG0004@2 NA|NA|NA P Ammonium Transporter Family KOPIJCMJ_02069 882082.SaccyDRAFT_0237 7.1e-49 201.4 Pseudonocardiales Bacteria 2GMMI@201174,4E2DH@85010,COG0582@1,COG0582@2 NA|NA|NA L Arm DNA-binding domain KOPIJCMJ_02072 882086.SacxiDRAFT_2995 7.5e-21 107.1 Pseudonocardiales Bacteria 2CK3K@1,2IQJH@201174,32SBH@2,4E5Q5@85010 NA|NA|NA S PFAM Ion channel KOPIJCMJ_02073 1463909.KL585974_gene2013 1.8e-30 139.8 Actinobacteria 5.4.99.28,5.4.99.29 ko:K06177,ko:K07052 ko00000,ko01000,ko03009,ko03016 Bacteria 2GKRA@201174,COG1266@1,COG1266@2 NA|NA|NA S Abortive infection protein KOPIJCMJ_02074 1352941.M877_24670 5.5e-75 287.7 Actinobacteria cbiQ ko:K02006,ko:K02008 ko02010,map02010 M00245,M00246 ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 Bacteria 2GKQ7@201174,COG0619@1,COG0619@2 NA|NA|NA P Cobalt ABC transporter KOPIJCMJ_02075 253839.SSNG_02891 2.3e-103 382.1 Actinobacteria cbiO ko:K02006,ko:K02008 ko02010,map02010 M00245,M00246 ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 Bacteria 2GJ0M@201174,COG1122@1,COG1122@2 NA|NA|NA P part of an ABC transporter complex. Responsible for energy coupling to the transport system KOPIJCMJ_02076 1283283.ATXA01000018_gene4136 2.5e-15 87.8 Frankiales glmU GO:0000270,GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0005975,GO:0005976,GO:0006022,GO:0006023,GO:0006024,GO:0006629,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009252,GO:0009273,GO:0009987,GO:0016051,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0019134,GO:0022610,GO:0030203,GO:0030260,GO:0033692,GO:0034637,GO:0034645,GO:0035635,GO:0040007,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044650,GO:0046872,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0070569,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1903509 2.3.1.157,2.7.7.23 ko:K04042,ko:K11528,ko:K16203 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000,ko01002 3.A.1.5.2 iJN678.glmU,iLJ478.TM1629 Bacteria 2GJS1@201174,4ERCR@85013,COG1207@1,COG1207@2 NA|NA|NA M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain KOPIJCMJ_02077 479435.Kfla_5708 3.1e-130 471.9 Propionibacteriales glmU GO:0000270,GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0005975,GO:0005976,GO:0006022,GO:0006023,GO:0006024,GO:0006629,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009252,GO:0009273,GO:0009987,GO:0016051,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0019134,GO:0022610,GO:0030203,GO:0030260,GO:0033692,GO:0034637,GO:0034645,GO:0035635,GO:0040007,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044650,GO:0046872,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0070569,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1903509 2.3.1.157,2.7.7.23 ko:K04042,ko:K11528,ko:K16203 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000,ko01002 3.A.1.5.2 iJN678.glmU,iLJ478.TM1629 Bacteria 2GJS1@201174,4DNA1@85009,COG1207@1,COG1207@2 NA|NA|NA M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain KOPIJCMJ_02079 1123320.KB889688_gene428 3.9e-57 228.0 Actinobacteria icaR Bacteria 2GMBW@201174,COG1309@1,COG1309@2 NA|NA|NA K transcriptional regulator KOPIJCMJ_02080 593907.Celgi_0587 6.2e-52 210.7 Cellulomonadaceae pecS Bacteria 2GJ6W@201174,4F19N@85016,COG1846@1,COG1846@2 NA|NA|NA K PFAM regulatory protein MarR KOPIJCMJ_02082 1095767.CAHD01000095_gene1567 1.3e-50 205.7 Cellulomonadaceae pstB 3.6.3.27 ko:K02036 ko02010,map02010 M00222 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 Bacteria 2GJQ3@201174,4F1S5@85016,COG1117@1,COG1117@2 NA|NA|NA P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system KOPIJCMJ_02083 526226.Gbro_2863 2e-82 312.8 Gordoniaceae GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009436,GO:0009987,GO:0015977,GO:0016054,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0032787,GO:0043427,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046185,GO:0046395,GO:0046487,GO:0071704,GO:0072329,GO:1901575 4.1.3.4,4.1.3.46 ko:K01640,ko:K18314 ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146 M00036,M00088 R01360,R08090,R10674 RC00502,RC00503,RC01118,RC01205,RC01946 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKTP@201174,4GBZC@85026,COG0119@1,COG0119@2 NA|NA|NA E HMGL-like KOPIJCMJ_02084 1120950.KB892823_gene493 3e-45 188.3 Propionibacteriales glgC GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008878,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0070566,GO:0071704,GO:1901576 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2768 Bacteria 2I2EF@201174,4DPN8@85009,COG0448@1,COG0448@2 NA|NA|NA G Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans KOPIJCMJ_02085 644548.SCNU_00065 1.9e-33 150.2 Gordoniaceae Bacteria 2GMMI@201174,4GD92@85026,COG0582@1,COG0582@2 NA|NA|NA L Belongs to the 'phage' integrase family KOPIJCMJ_02087 1463864.JOGO01000020_gene3357 6.1e-77 293.9 Actinobacteria ugd 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJQB@201174,COG1004@1,COG1004@2 NA|NA|NA M Belongs to the UDP-glucose GDP-mannose dehydrogenase family KOPIJCMJ_02088 479435.Kfla_7020 3.3e-30 137.1 Propionibacteriales ino1 GO:0003674,GO:0003824,GO:0004512,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009405,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016853,GO:0016872,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659 5.5.1.4 ko:K01858 ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130 R07324 RC01804 ko00000,ko00001,ko01000 Bacteria 2GKHB@201174,4DNQF@85009,COG1260@1,COG1260@2 NA|NA|NA I Myo-inositol-1-phosphate synthase KOPIJCMJ_02089 1380346.JNIH01000032_gene1139 5.2e-62 245.4 Actinobacteria 2.7.4.9 ko:K00943,ko:K08217 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 br01600,ko00000,ko00001,ko00002,ko01000,ko01504,ko02000 2.A.1.21.1,2.A.1.21.22 Bacteria 2GK5A@201174,COG2270@1,COG2270@2 NA|NA|NA S Major facilitator Superfamily KOPIJCMJ_02090 266940.Krad_0077 1.2e-54 219.9 Actinobacteria fhaA GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363 ko:K02283 ko00000,ko02035,ko02044 Bacteria 2GNU2@201174,COG1716@1,COG1716@2 NA|NA|NA T (FHA) domain KOPIJCMJ_02091 561175.KB894093_gene3929 1.7e-34 152.5 Streptosporangiales fhaB GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944 Bacteria 2GKA7@201174,4EJS2@85012,COG1716@1,COG1716@2 NA|NA|NA T Inner membrane component of T3SS, cytoplasmic domain KOPIJCMJ_02092 1449346.JQMO01000003_gene4362 1.8e-77 297.0 Kitasatospora 3.1.3.16 ko:K20074 ko00000,ko01000,ko01009 Bacteria 2GJ3M@201174,2M11G@2063,COG0631@1,COG0631@2 NA|NA|NA T Protein phosphatase 2C KOPIJCMJ_02093 935866.JAER01000017_gene4377 3.7e-119 435.3 Propionibacteriales rodA GO:0002682,GO:0002684,GO:0008150,GO:0009605,GO:0009607,GO:0009987,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051301,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0075136 ko:K03588,ko:K05364,ko:K05837 ko00550,ko04112,map00550,map04112 R04519 RC00005,RC00049 ko00000,ko00001,ko01011,ko02000,ko03036 2.A.103.1 Bacteria 2GJTI@201174,4DPN4@85009,COG0772@1,COG0772@2 NA|NA|NA D Belongs to the SEDS family KOPIJCMJ_02094 1120950.KB892743_gene3151 4.8e-130 471.5 Propionibacteriales pbpA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 ko:K05364 ko00550,map00550 R04519 RC00005,RC00049 ko00000,ko00001,ko01011 Bacteria 2GJUQ@201174,4DP0A@85009,COG0768@1,COG0768@2 NA|NA|NA M Penicillin binding protein transpeptidase domain KOPIJCMJ_02095 1054860.KB913030_gene3290 1.4e-121 443.7 Actinobacteria 2.7.11.1 ko:K12132 ko00000,ko01000,ko01001 Bacteria 2GJ1J@201174,COG0515@1,COG0515@2,COG2815@1,COG2815@2 NA|NA|NA KLT serine threonine protein kinase KOPIJCMJ_02096 266940.Krad_0158 1.7e-88 332.8 Actinobacteria fpg 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 2GKAM@201174,COG0266@1,COG0266@2 NA|NA|NA L Belongs to the FPG family KOPIJCMJ_02097 1048339.KB913029_gene1638 9.3e-30 136.3 Actinobacteria Bacteria 2CQNK@1,2I83S@201174,323RQ@2 NA|NA|NA S Family of unknown function (DUF5318) KOPIJCMJ_02098 1504319.GM45_1640 7.7e-156 557.8 unclassified Actinobacteria (class) mrcB 2.4.1.129,3.4.16.4 ko:K05365,ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 GT51 Bacteria 2GK21@201174,3UX6W@52018,COG0744@1,COG0744@2 NA|NA|NA M Transglycosylase KOPIJCMJ_02099 1449347.JQLN01000005_gene4485 1.3e-114 420.2 Kitasatospora Bacteria 2GJYA@201174,2M0JK@2063,COG5650@1,COG5650@2 NA|NA|NA S Pfam:DUF2029 KOPIJCMJ_02100 397278.JOJN01000003_gene1778 1.3e-53 217.2 Propionibacteriales Bacteria 2GJJX@201174,4DNS3@85009,COG0787@1,COG0787@2 NA|NA|NA M Alanine racemase, N-terminal domain KOPIJCMJ_02101 1348663.KCH_39330 2.4e-127 462.2 Kitasatospora femA Bacteria 2GJUD@201174,2M0RF@2063,COG2348@1,COG2348@2 NA|NA|NA V FemAB family KOPIJCMJ_02102 1121927.GOHSU_53_00040 2e-35 154.8 Gordoniaceae rpsF GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0019843,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071944,GO:0097159,GO:1901363,GO:1990904 ko:K02990 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011,ko03029 Bacteria 2IQHD@201174,4GEI3@85026,COG0360@1,COG0360@2 NA|NA|NA J Binds together with S18 to 16S ribosomal RNA KOPIJCMJ_02103 471853.Bcav_4180 9.6e-49 199.9 Actinobacteria ssb GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0042221,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071944,GO:0097159,GO:1901363 ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 ko00000,ko00001,ko03029,ko03032,ko03400 Bacteria 2GMM3@201174,COG0629@1,COG0629@2 NA|NA|NA L single-stranded DNA-binding protein KOPIJCMJ_02104 479431.Namu_5367 1.5e-28 131.7 Frankiales rpsR GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02963,ko:K03111,ko:K15125 ko03010,ko03030,ko03430,ko03440,ko05133,map03010,map03030,map03430,map03440,map05133 M00178 br01610,ko00000,ko00001,ko00002,ko00536,ko03011,ko03029,ko03032,ko03400 Bacteria 2IQ92@201174,4ESZ0@85013,COG0238@1,COG0238@2 NA|NA|NA J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit KOPIJCMJ_02105 1122611.KB903955_gene5558 1.8e-43 182.2 Streptosporangiales rplI GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02939 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IKX7@201174,4EIIV@85012,COG0359@1,COG0359@2 NA|NA|NA J binds to the 23S rRNA KOPIJCMJ_02109 590998.Celf_3037 4.9e-75 288.1 Actinobacteria Bacteria 2IG08@201174,COG1216@1,COG1216@2 NA|NA|NA M Glycosyltransferase, group 2 family protein KOPIJCMJ_02110 1449069.JMLO01000017_gene3331 1.3e-84 320.9 Actinobacteria Bacteria 2C825@1,2IGR2@201174,32RK8@2 NA|NA|NA KOPIJCMJ_02112 1068980.ARVW01000001_gene6598 8.8e-54 217.2 Actinobacteria Bacteria 2GNFE@201174,COG0558@1,COG0558@2 NA|NA|NA I Belongs to the CDP-alcohol phosphatidyltransferase class-I family KOPIJCMJ_02113 590998.Celf_3031 9e-45 186.4 Actinobacteria tagD 2.7.7.39 ko:K00980 ko00564,map00564 R00856 RC00002 ko00000,ko00001,ko01000 Bacteria 2GKU1@201174,COG0615@1,COG0615@2 NA|NA|NA IM Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose KOPIJCMJ_02114 979556.MTES_0953 1.3e-53 217.2 Bacteria wcoF Bacteria COG0438@1,COG0438@2 NA|NA|NA M transferase activity, transferring glycosyl groups KOPIJCMJ_02115 1120936.KB907208_gene780 3.8e-74 285.8 Streptosporangiales rfbP Bacteria 2GK0M@201174,4EGMN@85012,COG2148@1,COG2148@2 NA|NA|NA M Bacterial sugar transferase KOPIJCMJ_02116 1463901.JOIY01000024_gene6226 9.1e-207 726.5 Actinobacteria serA 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GJGA@201174,COG0111@1,COG0111@2 NA|NA|NA E Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family KOPIJCMJ_02117 1032480.MLP_18030 2.5e-157 561.6 Propionibacteriales ilvC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0008677,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKXA@201174,4DNFA@85009,COG0059@1,COG0059@2 NA|NA|NA EH Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate KOPIJCMJ_02118 67352.JODS01000004_gene5852 1.7e-64 252.3 Actinobacteria ilvN GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0030312,GO:0032991,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 iECO103_1326.ilvN,iJN678.ilvN Bacteria 2GJCH@201174,COG0440@1,COG0440@2 NA|NA|NA E Acetolactate synthase KOPIJCMJ_02119 1122611.KB903963_gene4707 7.6e-27 125.9 Streptosporangiales ilvB 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKU4@201174,4EG2X@85012,COG0028@1,COG0028@2 NA|NA|NA EH Thiamine pyrophosphate enzyme, central domain KOPIJCMJ_02120 397278.JOJN01000001_gene2902 6.2e-103 380.6 Propionibacteriales flgG GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588 ko:K02390 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 2I3KN@201174,4DNCD@85009,COG4786@1,COG4786@2 NA|NA|NA N Flagellar basal body rod FlgEFG protein C-terminal KOPIJCMJ_02121 196162.Noca_0750 1.4e-14 85.5 Propionibacteriales flbD ko:K02385 ko00000,ko02035 Bacteria 2GRTC@201174,4DVPB@85009,COG1582@1,COG1582@2 NA|NA|NA N Flagellar protein (FlbD) KOPIJCMJ_02122 1283287.KB822581_gene1417 3.4e-98 364.8 Propionibacteriales motA ko:K02556 ko02020,ko02030,ko02040,map02020,map02030,map02040 ko00000,ko00001,ko02000,ko02035 1.A.30.1 Bacteria 2I92C@201174,4DP5S@85009,COG1291@1,COG1291@2 NA|NA|NA N MotA/TolQ/ExbB proton channel family KOPIJCMJ_02123 1298863.AUEP01000003_gene2824 2.4e-79 302.4 Propionibacteriales motB ko:K02557 ko02030,ko02040,map02030,map02040 ko00000,ko00001,ko02000,ko02035 1.A.30.1 Bacteria 2IG81@201174,4DTTH@85009,COG1360@1,COG1360@2 NA|NA|NA N Membrane MotB of proton-channel complex MotA/MotB KOPIJCMJ_02124 935866.JAER01000042_gene2752 8.2e-28 130.2 Propionibacteriales fliL ko:K02415 ko00000,ko02035 Bacteria 2ITFQ@201174,4DV67@85009,COG1580@1,COG1580@2 NA|NA|NA N Flagellar basal body-associated protein FliL KOPIJCMJ_02125 1283287.KB822581_gene1414 2.6e-87 328.9 Propionibacteriales fliM ko:K02416,ko:K02417 ko02030,ko02040,map02030,map02040 ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 Bacteria 2ICP2@201174,4DNNZ@85009,COG1868@1,COG1868@2 NA|NA|NA N Flagellar motor switch protein FliM KOPIJCMJ_02126 196162.Noca_0745 2.4e-35 156.0 Propionibacteriales fliN ko:K02417 ko02030,ko02040,map02030,map02040 ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 Bacteria 2IGHQ@201174,4DREH@85009,COG1886@1,COG1886@2 NA|NA|NA NU Type III flagellar switch regulator (C-ring) FliN C-term KOPIJCMJ_02127 196162.Noca_0744 2.8e-20 105.1 Propionibacteriales fliP ko:K02418,ko:K02419 ko02040,map02040 ko00000,ko00001,ko02035,ko02044 3.A.6.2 Bacteria 2GREW@201174,4DVDJ@85009,COG3190@1,COG3190@2 NA|NA|NA N Flagellar biosynthesis protein, FliO KOPIJCMJ_02128 1304865.JAGF01000001_gene3502 7.2e-68 263.8 Cellulomonadaceae Bacteria 2HD07@201174,4F18I@85016,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family KOPIJCMJ_02129 882083.SacmaDRAFT_2733 4.8e-35 155.6 Pseudonocardiales crtY 1.14.19.49,5.5.1.19 ko:K06443,ko:K14257 ko00253,ko00404,ko00906,ko01057,ko01100,ko01110,ko01130,map00253,map00404,map00906,map01057,map01100,map01110,map01130 M00097,M00790,M00823 R03824,R04801,R05341,R05456,R06962,R07856,R11106,R11478 RC00949,RC01004,RC01964 ko00000,ko00001,ko00002,ko01000 Bacteria 2GNH7@201174,4E8RQ@85010,COG0644@1,COG0644@2 NA|NA|NA C Lycopene cyclase protein KOPIJCMJ_02130 1035308.AQYY01000001_gene2432 9.1e-40 169.9 Clostridia Bacteria 1VQQ3@1239,255AM@186801,COG5646@1,COG5646@2 NA|NA|NA S Domain of unknown function (DU1801) KOPIJCMJ_02131 471853.Bcav_3980 5.6e-152 544.3 Actinobacteria Bacteria 2GJ8H@201174,COG3119@1,COG3119@2 NA|NA|NA P Pfam Sulfatase KOPIJCMJ_02132 103733.JNYO01000019_gene2036 3.5e-119 434.9 Pseudonocardiales Bacteria 2C1EG@1,2GK4W@201174,2Z7MZ@2,4DZP1@85010 NA|NA|NA KOPIJCMJ_02133 671143.DAMO_1527 3.2e-63 248.8 unclassified Bacteria yrbG ko:K07301 ko00000,ko02000 2.A.19.5 Bacteria 2NPPD@2323,COG0530@1,COG0530@2 NA|NA|NA P Sodium/calcium exchanger protein KOPIJCMJ_02134 1035308.AQYY01000001_gene1812 2.1e-87 329.7 Bacteria Bacteria COG4325@1,COG4325@2 NA|NA|NA KOPIJCMJ_02135 937777.Deipe_2178 1.3e-29 137.9 Bacteria 3.4.21.107 ko:K04771,ko:K08372 ko01503,ko02020,map01503,map02020 M00728 ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 Bacteria COG0265@1,COG0265@2 NA|NA|NA O serine-type endopeptidase activity KOPIJCMJ_02136 526222.Desal_3467 1.7e-67 263.1 Desulfovibrionales Bacteria 1RAKG@1224,2MAVS@213115,2WN6A@28221,42QYD@68525,COG2199@1,COG3706@2 NA|NA|NA T Diguanylate cyclase, GGDEF domain KOPIJCMJ_02137 710421.Mycch_1475 1.3e-96 359.4 Mycobacteriaceae ahpC 1.11.1.15 ko:K03386 ko04214,map04214 ko00000,ko00001,ko01000,ko04147 Bacteria 234SP@1762,2GM74@201174,COG0450@1,COG0450@2 NA|NA|NA O Alkyl hydroperoxide reductase KOPIJCMJ_02138 1120950.KB892775_gene1183 3.4e-127 461.8 Propionibacteriales arsB Bacteria 2GMQJ@201174,4DN5A@85009,COG1055@1,COG1055@2 NA|NA|NA P Bacterial Na+/H+ antiporter B (NhaB) KOPIJCMJ_02139 408672.NBCG_01925 8.3e-93 347.1 Propionibacteriales 3.2.1.83 ko:K20846 ko00000,ko01000 GH16 Bacteria 2GTJC@201174,4DQGW@85009,COG2273@1,COG2273@2 NA|NA|NA G Glycosyl hydrolases family 16 KOPIJCMJ_02140 590998.Celf_2836 3.5e-115 422.2 Cellulomonadaceae ydhC ko:K07552,ko:K18552 br01600,ko00000,ko01504,ko02000 2.A.1.2,2.A.1.2.3 Bacteria 2I2Q2@201174,4F0N0@85016,COG0477@1,COG0477@2 NA|NA|NA EGP TIGRFAM drug resistance transporter, Bcr CflA subfamily KOPIJCMJ_02141 1713.JOFV01000017_gene106 6.8e-41 173.3 Cellulomonadaceae ywzG Bacteria 2IQSE@201174,4F1CD@85016,COG1695@1,COG1695@2 NA|NA|NA K Transcriptional regulator PadR-like family KOPIJCMJ_02142 1240349.ANGC01000051_gene4101 8.3e-148 530.4 Nocardiaceae Bacteria 2CA5R@1,2GM6V@201174,2Z81H@2,4FVE9@85025 NA|NA|NA KOPIJCMJ_02143 1179773.BN6_18910 6.3e-31 140.6 Pseudonocardiales XK27_02315 Bacteria 2IMR2@201174,4E5VC@85010,COG5646@1,COG5646@2 NA|NA|NA S Domain of unknown function (DU1801) KOPIJCMJ_02144 2045.KR76_07085 2.6e-31 142.1 Propionibacteriales VY92_09940 ko:K09796 ko00000,ko03110 Bacteria 2IR3D@201174,4DS2B@85009,COG2847@1,COG2847@2 NA|NA|NA S Copper chaperone PCu(A)C KOPIJCMJ_02146 134676.ACPL_8199 0.0 1100.1 Micromonosporales katG GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 Bacteria 2GJFP@201174,4D8UR@85008,COG0376@1,COG0376@2 NA|NA|NA P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity KOPIJCMJ_02147 979556.MTES_0239 5.7e-116 423.7 Actinobacteria Bacteria 2BF9K@1,2ISER@201174,3292G@2 NA|NA|NA KOPIJCMJ_02149 1121385.AQXW01000004_gene3278 9.4e-15 86.3 Dermacoccaceae phhB 3.5.4.33,4.2.1.96 ko:K01724,ko:K11991 ko00790,map00790 R04734,R10223 RC00477,RC01208 ko00000,ko00001,ko01000,ko03016,ko04147 Bacteria 1ZW7J@145357,2IHZE@201174,COG2154@1,COG2154@2 NA|NA|NA H Pterin 4 alpha carbinolamine dehydratase KOPIJCMJ_02152 1463820.JOGW01000004_gene4606 7.7e-137 494.2 Actinobacteria cdr ko:K04085 ko04122,map04122 ko00000,ko00001,ko01000,ko03016 Bacteria 2H7WY@201174,COG0446@1,COG0446@2,COG0607@1,COG0607@2 NA|NA|NA P oxidoreductase KOPIJCMJ_02153 1122182.KB903816_gene1626 4.5e-26 123.2 Micromonosporales cspA ko:K03704 ko00000,ko03000 Bacteria 2GQRU@201174,4DEWR@85008,COG1278@1,COG1278@2 NA|NA|NA K Cold shock KOPIJCMJ_02155 1341646.CBMO010000035_gene4653 1.7e-139 503.1 Mycobacteriaceae sulP GO:0000103,GO:0000166,GO:0003333,GO:0003674,GO:0005215,GO:0005310,GO:0005326,GO:0005342,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006790,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0008152,GO:0008272,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015103,GO:0015116,GO:0015138,GO:0015141,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015238,GO:0015318,GO:0015556,GO:0015698,GO:0015711,GO:0015740,GO:0015741,GO:0015744,GO:0015800,GO:0015807,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0017076,GO:0019001,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0036094,GO:0042221,GO:0042493,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070778,GO:0071422,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0097159,GO:0098656,GO:0098660,GO:0098661,GO:1901265,GO:1901363,GO:1901682,GO:1902358,GO:1902475,GO:1903825,GO:1905039 ko:K03321 ko00000,ko02000 2.A.53.3 Bacteria 236K7@1762,2GJCB@201174,COG0659@1,COG0659@2 NA|NA|NA P Sulfate transporter KOPIJCMJ_02156 717773.Thicy_0930 1.3e-62 246.9 Bacteria Bacteria COG1887@1,COG1887@2 NA|NA|NA M Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC KOPIJCMJ_02158 862751.SACTE_5342 2.2e-227 795.0 Actinobacteria sir GO:0000096,GO:0000097,GO:0000103,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016002,GO:0016053,GO:0016491,GO:0016667,GO:0016673,GO:0019344,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050311,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.14.13.83,1.7.7.1,1.8.7.1 ko:K00366,ko:K00392,ko:K02229 ko00860,ko00910,ko00920,ko01100,ko01120,map00860,map00910,map00920,map01100,map01120 M00176,M00531 R00790,R00859,R03600,R05217 RC00065,RC00176,RC01979 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJRN@201174,COG0155@1,COG0155@2 NA|NA|NA C Belongs to the nitrite and sulfite reductase 4Fe-4S domain family KOPIJCMJ_02159 1121946.AUAX01000030_gene1321 1.2e-10 72.0 Micromonosporales Bacteria 2GQKE@201174,4DGEE@85008,COG3677@1,COG3677@2 NA|NA|NA L Transposase KOPIJCMJ_02160 593907.Celgi_1496 1.6e-81 309.3 Cellulomonadaceae cysH GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004604,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016667,GO:0016671,GO:0019344,GO:0019752,GO:0040007,GO:0043436,GO:0043866,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.8.4.10,1.8.4.8 ko:K00390 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R02021 RC00007,RC02862 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv2392 Bacteria 2GJ3Z@201174,4F0TA@85016,COG0175@1,COG0175@2 NA|NA|NA EH Belongs to the PAPS reductase family. CysH subfamily KOPIJCMJ_02161 1306406.ASHX01000002_gene4651 4.6e-142 510.8 Actinobacteria cysD 1.8.4.10,1.8.4.8,2.7.7.4 ko:K00390,ko:K00957 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R02021,R04929 RC00007,RC02809,RC02862,RC02889 ko00000,ko00001,ko00002,ko01000 Bacteria 2GN85@201174,COG0175@1,COG0175@2 NA|NA|NA EH sulfate adenylyltransferase KOPIJCMJ_02162 446462.Amir_1235 1.5e-148 532.7 Pseudonocardiales cysN 2.7.1.25,2.7.7.4 ko:K00955,ko:K00956 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00509,R00529,R04928,R04929 RC00002,RC00078,RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJDX@201174,4DYZW@85010,COG2895@1,COG2895@2 NA|NA|NA P Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily KOPIJCMJ_02163 1713.JOFV01000005_gene2127 3.5e-105 388.7 Cellulomonadaceae cysG GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009628,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.13.11.79,1.3.1.76,2.1.1.107,4.99.1.4 ko:K02302,ko:K02303,ko:K02304,ko:K04719 ko00740,ko00860,ko01100,ko01110,ko01120,map00740,map00860,map01100,map01110,map01120 M00121 R02864,R03194,R03947,R09083 RC00003,RC00435,RC00871,RC01012,RC01034,RC02413 ko00000,ko00001,ko00002,ko01000 iECIAI1_1343.ECIAI1_3507,iECSE_1348.ECSE_3630,iEcE24377_1341.EcE24377A_3838,iJN746.PP_3999,iPC815.YPO0158 Bacteria 2GK3B@201174,4F0HX@85016,COG0007@1,COG0007@2 NA|NA|NA H PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase KOPIJCMJ_02164 1463856.JOHY01000003_gene5078 6.8e-22 111.3 Actinobacteria Bacteria 2GS51@201174,COG2138@1,COG2138@2 NA|NA|NA P cobalamin (vitamin B12) biosynthesis CbiX protein KOPIJCMJ_02165 1123322.KB904735_gene1568 5.5e-100 371.3 Actinobacteria patB 4.4.1.8 ko:K14155 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 R00782,R01286,R02408,R04941 RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko01000,ko01007 Bacteria 2GJFQ@201174,COG1168@1,COG1168@2 NA|NA|NA E Aminotransferase, class I KOPIJCMJ_02166 1122622.ATWJ01000012_gene997 3.7e-18 96.7 Intrasporangiaceae Bacteria 2E460@1,2GQGS@201174,32Z20@2,4FHQE@85021 NA|NA|NA KOPIJCMJ_02167 1120936.KB907216_gene3853 8e-237 826.6 Streptosporangiales sucA GO:0000287,GO:0003674,GO:0003824,GO:0004591,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016624,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0019842,GO:0022900,GO:0030312,GO:0030976,GO:0032991,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0048037,GO:0050439,GO:0050662,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234 1.2.4.2,4.1.1.71 ko:K00164,ko:K01616 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1248c,iSSON_1240.SSON_0677,iYL1228.KPN_00732 Bacteria 2GIU6@201174,4EHHS@85012,COG0508@1,COG0508@2,COG0567@1,COG0567@2 NA|NA|NA C 2-oxoglutarate dehydrogenase C-terminal KOPIJCMJ_02168 1123023.JIAI01000055_gene2528 1.5e-68 266.5 Actinobacteria ko:K03496 ko00000,ko03036,ko04812 Bacteria 2IHZI@201174,COG1192@1,COG1192@2 NA|NA|NA D PFAM Cobyrinic acid a,c-diamide synthase KOPIJCMJ_02171 1274.HX89_14490 2.9e-59 236.9 Actinobacteria Bacteria 2EWQ2@1,2IT4U@201174,33Q1X@2 NA|NA|NA KOPIJCMJ_02173 1048339.KB913029_gene453 9.9e-37 161.0 Frankiales Bacteria 2IHBR@201174,4EW9H@85013,COG0741@1,COG0741@2,COG3103@1,COG4991@2 NA|NA|NA MT Transglycosylase SLT domain KOPIJCMJ_02174 263358.VAB18032_03310 7.9e-61 241.5 Micromonosporales Bacteria 2GKZ9@201174,4DGWY@85008,COG5555@1,COG5555@2 NA|NA|NA N Integrin alpha (beta-propellor repeats). KOPIJCMJ_02175 500153.JOEK01000009_gene5174 5.5e-55 221.5 Actinobacteria rfaF ko:K02843 ko00540,ko01100,map00540,map01100 M00080 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 GT9 Bacteria 2GMZG@201174,COG0859@1,COG0859@2 NA|NA|NA M PFAM glycosyl transferase family 9 KOPIJCMJ_02177 326424.FRAAL2165 1.1e-41 176.8 Frankiales 2.7.8.5 ko:K00995 ko00564,ko01100,map00564,map01100 R01801 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 Bacteria 2IDSP@201174,4ET6D@85013,COG0558@1,COG0558@2 NA|NA|NA I CDP-alcohol phosphatidyltransferase KOPIJCMJ_02178 1380347.JNII01000005_gene3165 8.8e-25 120.6 Frankiales ko:K09807 ko00000 Bacteria 2GM1U@201174,4ET95@85013,COG2968@1,COG2968@2 NA|NA|NA S Protein of unknown function (DUF541) KOPIJCMJ_02179 1048339.KB913029_gene4363 5.3e-100 370.9 Frankiales metF GO:0003674,GO:0003824,GO:0004489,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJTN@201174,4ERKZ@85013,COG0685@1,COG0685@2 NA|NA|NA E Methylenetetrahydrofolate reductase KOPIJCMJ_02180 1123320.KB889675_gene3878 2.9e-108 398.7 Actinobacteria idsA 2.5.1.1,2.5.1.10,2.5.1.29 ko:K13787 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00365 R01658,R02003,R02061 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 Bacteria 2GJEK@201174,COG0142@1,COG0142@2 NA|NA|NA H Belongs to the FPP GGPP synthase family KOPIJCMJ_02181 1504319.GM45_1000 1.8e-201 708.8 unclassified Actinobacteria (class) crtI 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 ko:K10027 ko00906,ko01100,ko01110,map00906,map01100,map01110 R04787,R04798,R04800,R09691,R09692 RC01214,RC02088,RC02605 ko00000,ko00001,ko01000 Bacteria 2GJAV@201174,3UXB3@52018,COG1233@1,COG1233@2 NA|NA|NA Q Flavin containing amine oxidoreductase KOPIJCMJ_02182 1121019.AUMN01000024_gene3573 2.1e-83 316.6 Micrococcaceae ko:K14337,ko:K14339 ko00000,ko01000,ko01003 Bacteria 1WCDZ@1268,2AMJ0@1,2I3ZG@201174,31CER@2 NA|NA|NA KOPIJCMJ_02183 1155718.KB891896_gene2107 4.6e-13 81.3 Actinobacteria Bacteria 2IKZ0@201174,COG2732@1,COG2732@2 NA|NA|NA K Barstar (barnase inhibitor) KOPIJCMJ_02184 29306.JOBE01000002_gene2854 2.8e-28 131.7 Actinobacteria 3.1.27.3 ko:K01167,ko:K15125 ko05133,map05133 ko00000,ko00001,ko00536,ko01000,ko03016,ko03019 Bacteria 2IHPV@201174,COG4290@1,COG4290@2 NA|NA|NA F Ribonuclease KOPIJCMJ_02185 1504319.GM45_0995 1.4e-90 339.7 unclassified Actinobacteria (class) crtB GO:0003674,GO:0003824,GO:0004337,GO:0004659,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016108,GO:0016109,GO:0016114,GO:0016116,GO:0016117,GO:0016740,GO:0016765,GO:0016767,GO:0042440,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046148,GO:0071704,GO:1901576 2.5.1.21,2.5.1.32,2.5.1.96,2.5.1.99 ko:K00801,ko:K02291,ko:K10208 ko00100,ko00906,ko00909,ko01062,ko01100,ko01110,ko01130,map00100,map00906,map00909,map01062,map01100,map01110,map01130 M00097 R00702,R02065,R02872,R04218,R06223,R07270,R07652,R09793,R10177 RC00362,RC00796,RC01101,RC02839,RC02869 ko00000,ko00001,ko00002,ko01000,ko01006 Bacteria 2HFT6@201174,3UXMW@52018,COG1562@1,COG1562@2 NA|NA|NA I Squalene/phytoene synthase KOPIJCMJ_02186 1246995.AFR_09710 1.2e-25 123.2 Micromonosporales Bacteria 2E9MI@1,2IMX9@201174,333U6@2,4DG5M@85008 NA|NA|NA S lycopene cyclase KOPIJCMJ_02187 134676.ACPL_1706 2e-29 135.6 Micromonosporales crtY Bacteria 2CPEY@1,2I84R@201174,32SIY@2,4DFG6@85008 NA|NA|NA S lycopene cyclase domain KOPIJCMJ_02191 710696.Intca_3499 6.1e-163 580.5 Intrasporangiaceae Bacteria 2GS79@201174,4FFP0@85021,COG3547@1,COG3547@2 NA|NA|NA L Transposase KOPIJCMJ_02192 1184609.KILIM_074_00180 1.3e-22 112.1 Actinobacteria Bacteria 2FF53@1,2H9GT@201174,34737@2 NA|NA|NA KOPIJCMJ_02193 710696.Intca_3496 3.3e-50 204.1 Intrasporangiaceae ko:K07171 ko00000,ko01000,ko02048 Bacteria 2HY4S@201174,4FJRX@85021,COG2337@1,COG2337@2 NA|NA|NA L PemK-like, MazF-like toxin of type II toxin-antitoxin system KOPIJCMJ_02194 1123504.JQKD01000081_gene367 4e-10 71.6 Comamonadaceae Bacteria 1NTVA@1224,2DBKS@1,2VPHF@28216,2Z9UX@2,4ABZ0@80864 NA|NA|NA KOPIJCMJ_02196 526225.Gobs_1409 2.6e-45 189.1 Actinobacteria apt 2.4.2.7 ko:K00759 ko00230,ko01100,map00230,map01100 R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko04147 Bacteria 2IHB6@201174,COG0503@1,COG0503@2 NA|NA|NA F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis KOPIJCMJ_02197 1184609.KILIM_042_00240 8.8e-22 110.5 Actinobacteria ko:K03088 ko00000,ko03021 Bacteria 2IRNG@201174,COG1595@1,COG1595@2 NA|NA|NA K belongs to the sigma-70 factor family, ECF subfamily KOPIJCMJ_02198 290340.AAur_1158 3.3e-29 136.0 Actinobacteria ko:K03088 ko00000,ko03021 Bacteria 2IKVM@201174,COG1595@1,COG1595@2 NA|NA|NA K belongs to the sigma-70 factor family, ECF subfamily KOPIJCMJ_02199 471853.Bcav_3589 1.1e-37 163.7 Bacteria MA20_05910 ko:K03668,ko:K09914 ko00000 Bacteria COG3187@1,COG3187@2 NA|NA|NA O response to heat KOPIJCMJ_02202 35754.JNYJ01000086_gene2338 9.7e-22 109.4 Micromonosporales Bacteria 2EH37@1,2GQTI@201174,33AV6@2,4DFMM@85008 NA|NA|NA KOPIJCMJ_02203 35754.JNYJ01000011_gene741 2.1e-22 111.3 Micromonosporales yozG ko:K07727 ko00000,ko03000 Bacteria 2GQZM@201174,4DEY7@85008,COG3655@1,COG3655@2 NA|NA|NA K Cro/C1-type HTH DNA-binding domain KOPIJCMJ_02204 1043205.AFYF01000045_gene2925 1.6e-08 66.6 Intrasporangiaceae Bacteria 2ET1V@1,2GZYR@201174,33KK0@2,4FI7B@85021 NA|NA|NA S Protein of unknown function (DUF2975) KOPIJCMJ_02205 644283.Micau_3475 1.9e-27 129.4 Micromonosporales ppaX 3.1.3.18,3.6.1.1 ko:K01091,ko:K06019,ko:K16017 ko00190,ko00630,ko01051,ko01100,ko01110,ko01130,map00190,map00630,map01051,map01100,map01110,map01130 R01334,R06587 RC00017,RC00078 ko00000,ko00001,ko01000 Bacteria 2I9FC@201174,4DFT5@85008,COG0546@1,COG0546@2 NA|NA|NA S HAD-superfamily hydrolase, subfamily IA, variant 3 KOPIJCMJ_02206 1120933.ATUY01000009_gene1413 3.1e-208 731.5 Actinobacteria malL 3.2.1.10 ko:K01182 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00801,R01718,R01791,R06199 RC00028,RC00059,RC00077,RC00451 ko00000,ko00001,ko01000 GH13 Bacteria 2GKS4@201174,4D32X@85005,COG0366@1,COG0366@2 NA|NA|NA G Alpha amylase, catalytic domain protein KOPIJCMJ_02209 235985.BBPN01000058_gene7572 2e-233 815.1 Streptacidiphilus pccB 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIRU@201174,2NGRN@228398,COG4799@1,COG4799@2 NA|NA|NA I Carboxyl transferase domain KOPIJCMJ_02210 1957.JODX01000002_gene4462 4.8e-46 191.8 Actinobacteria birA GO:0000166,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004077,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009305,GO:0009374,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0017053,GO:0017076,GO:0017144,GO:0018130,GO:0018271,GO:0019538,GO:0019752,GO:0019842,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032991,GO:0033218,GO:0033293,GO:0034641,GO:0035639,GO:0036094,GO:0036211,GO:0042364,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043565,GO:0043603,GO:0043604,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1990837 2.7.1.33,6.3.4.15 ko:K01947,ko:K03524 ko00770,ko00780,ko01100,map00770,map00780,map01100 M00120 R01074,R02971,R03018,R04391,R05145 RC00002,RC00017,RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko00002,ko01000,ko03000 Bacteria 2GN8Q@201174,COG0340@1,COG0340@2 NA|NA|NA H biotin lipoate A B protein ligase KOPIJCMJ_02211 500153.JOEK01000003_gene1233 4.5e-58 231.9 Actinobacteria cya 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 Bacteria 2GN02@201174,COG2114@1,COG2114@2 NA|NA|NA T PFAM Adenylyl cyclase class-3 4 guanylyl cyclase KOPIJCMJ_02212 1048339.KB913029_gene20 6.5e-39 167.2 Frankiales ko:K07015 ko00000 Bacteria 2IFFV@201174,4ET34@85013,COG2246@1,COG2246@2 NA|NA|NA S PFAM GtrA family protein KOPIJCMJ_02213 1050202.KB913024_gene29 5.1e-151 540.8 Actinopolysporales acdA GO:0000062,GO:0000166,GO:0003674,GO:0003824,GO:0003995,GO:0004085,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005759,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009605,GO:0009719,GO:0009725,GO:0009987,GO:0009991,GO:0010033,GO:0014070,GO:0016020,GO:0016042,GO:0016043,GO:0016054,GO:0016491,GO:0016627,GO:0017076,GO:0019395,GO:0019605,GO:0019626,GO:0019752,GO:0022607,GO:0030258,GO:0030554,GO:0031090,GO:0031667,GO:0031960,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033218,GO:0033539,GO:0033993,GO:0034440,GO:0036094,GO:0042221,GO:0042594,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046359,GO:0046395,GO:0046459,GO:0048037,GO:0048545,GO:0050660,GO:0050662,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051384,GO:0052890,GO:0055114,GO:0065003,GO:0070013,GO:0071704,GO:0071840,GO:0072329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901567,GO:1901575,GO:1901681 1.3.8.1 ko:K00248,ko:K18244 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 Bacteria 2GMEM@201174,407ZG@622450,COG1960@1,COG1960@2 NA|NA|NA I Acyl-CoA dehydrogenase, C-terminal domain KOPIJCMJ_02214 469383.Cwoe_5648 7.3e-58 231.1 Rubrobacteria 5.1.3.3 ko:K01785 ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130 M00632 R01602,R10619 RC00563 ko00000,ko00001,ko00002,ko01000 Bacteria 2HQKA@201174,4CS5Q@84995,COG2017@1,COG2017@2 NA|NA|NA G Aldose 1-epimerase KOPIJCMJ_02215 1048339.KB913029_gene1756 9.1e-37 160.6 Actinobacteria Bacteria 28IGY@1,2H6U5@201174,2Z8I9@2 NA|NA|NA KOPIJCMJ_02216 397278.JOJN01000018_gene3503 1.4e-135 489.6 Propionibacteriales 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 Bacteria 2GIRF@201174,4DN8M@85009,COG2217@1,COG2217@2 NA|NA|NA P Heavy-metal-associated domain KOPIJCMJ_02217 196162.Noca_0411 9.2e-14 84.0 Propionibacteriales Bacteria 2GMVK@201174,4DTD1@85009,COG4243@1,COG4243@2 NA|NA|NA S VKc KOPIJCMJ_02218 397278.JOJN01000010_gene2233 4.8e-08 65.5 Propionibacteriales Bacteria 2BXNT@1,2IIU0@201174,30VN0@2,4DQTR@85009 NA|NA|NA S Septum formation KOPIJCMJ_02219 446466.Cfla_3211 3.6e-53 214.9 Actinobacteria Bacteria 2CJUD@1,2IS5A@201174,2ZW9H@2 NA|NA|NA KOPIJCMJ_02220 1151122.AQYD01000007_gene568 1.6e-56 226.1 Microbacteriaceae phhB 3.5.4.33,4.2.1.96 ko:K01724,ko:K11991 ko00790,map00790 R04734,R10223 RC00477,RC01208 ko00000,ko00001,ko01000,ko03016,ko04147 Bacteria 2IHZE@201174,4FP56@85023,COG0596@1,COG0596@2,COG2154@1,COG2154@2 NA|NA|NA H Pterin 4 alpha carbinolamine dehydratase KOPIJCMJ_02221 590998.Celf_1077 1.4e-56 226.5 Cellulomonadaceae ko:K02081,ko:K03436 ko00000,ko03000 Bacteria 2GKWM@201174,4F32F@85016,COG1349@1,COG1349@2 NA|NA|NA K DeoR C terminal sensor domain KOPIJCMJ_02222 263358.VAB18032_19950 8.4e-92 343.6 Micromonosporales estA ko:K03930 ko00000,ko01000 CE1 Bacteria 2GJX4@201174,4D9HJ@85008,COG0627@1,COG0627@2 NA|NA|NA S Putative esterase KOPIJCMJ_02224 1265502.KB905943_gene2772 1.3e-266 925.6 Comamonadaceae fadH 1.3.1.34 ko:K00219 ko00000,ko01000 Bacteria 1MVE0@1224,2VIW3@28216,4ABSX@80864,COG0446@1,COG0446@2,COG1902@1,COG1902@2 NA|NA|NA C NADH flavin oxidoreductase NADH oxidase KOPIJCMJ_02225 298654.FraEuI1c_0532 2.2e-109 402.1 Actinobacteria rbsC-2 ko:K02057 M00221 ko00000,ko00002,ko02000 3.A.1.2 Bacteria 2GKMB@201174,COG1079@1,COG1079@2 NA|NA|NA S Belongs to the binding-protein-dependent transport system permease family KOPIJCMJ_02226 298654.FraEuI1c_0533 3e-97 362.1 Frankiales ko:K02057 M00221 ko00000,ko00002,ko02000 3.A.1.2 Bacteria 2GKAZ@201174,4EU1I@85013,COG4603@1,COG4603@2 NA|NA|NA S Belongs to the binding-protein-dependent transport system permease family KOPIJCMJ_02227 1123258.AQXZ01000014_gene4985 1.3e-66 259.6 Nocardiaceae mglA 3.6.3.17 ko:K02056 M00221 ko00000,ko00002,ko01000,ko02000 3.A.1.2 Bacteria 2H7KJ@201174,4G9EK@85025,COG3845@1,COG3845@2 NA|NA|NA S ATPases associated with a variety of cellular activities KOPIJCMJ_02228 1043205.AFYF01000057_gene2681 1e-119 436.4 Intrasporangiaceae sucD 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 Bacteria 2GK00@201174,4FFWQ@85021,COG0074@1,COG0074@2 NA|NA|NA C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit KOPIJCMJ_02229 649831.L083_1047 3.2e-140 505.0 Micromonosporales sucC 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKSB@201174,4DAKW@85008,COG0045@1,COG0045@2 NA|NA|NA C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit KOPIJCMJ_02230 710696.Intca_1058 1.9e-50 205.3 Intrasporangiaceae icmB 5.4.99.13,5.4.99.2,5.4.99.63 ko:K01849,ko:K11942,ko:K14447 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R00833,R09292 RC00395,RC02835 ko00000,ko00001,ko00002,ko01000 Bacteria 2IFJD@201174,4FGQ3@85021,COG2185@1,COG2185@2 NA|NA|NA I B12 binding domain KOPIJCMJ_02231 1123320.KB889574_gene5500 1.5e-272 945.7 Actinobacteria pcrA GO:0000018,GO:0000166,GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030312,GO:0030554,GO:0031323,GO:0031324,GO:0032392,GO:0032508,GO:0032552,GO:0032554,GO:0032558,GO:0032564,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0036094,GO:0040007,GO:0042623,GO:0043138,GO:0043140,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0045910,GO:0045934,GO:0046483,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 2GISS@201174,COG0210@1,COG0210@2 NA|NA|NA L DNA helicase KOPIJCMJ_02232 1504319.GM45_2400 3.2e-46 193.0 Actinobacteria ko:K01446 R04112 RC00064,RC00141 ko00000 Bacteria 2IG5X@201174,COG3409@1,COG3409@2 NA|NA|NA M Peptidoglycan-binding domain 1 protein KOPIJCMJ_02233 1146883.BLASA_4228 1.3e-75 289.7 Frankiales Bacteria 2GMVD@201174,4ESNR@85013,COG2120@1,COG2120@2 NA|NA|NA S Evidence 2b Function of strongly homologous gene KOPIJCMJ_02234 1304865.JAGF01000001_gene590 1e-22 112.8 Bacteria Bacteria 2E4PN@1,32ZIA@2 NA|NA|NA KOPIJCMJ_02235 1394178.AWOO02000003_gene2641 1e-76 293.1 Streptosporangiales degU ko:K07684 ko02020,map02020 M00471 ko00000,ko00001,ko00002,ko02022 Bacteria 2GIVA@201174,4EHIU@85012,COG2197@1,COG2197@2 NA|NA|NA T helix_turn_helix, Lux Regulon KOPIJCMJ_02236 58123.JOFJ01000019_gene3792 3.7e-67 262.3 Streptosporangiales tcsS3 Bacteria 2GJ4J@201174,4EG3Q@85012,COG1983@1,COG1983@2,COG4585@1,COG4585@2 NA|NA|NA KT PspC domain KOPIJCMJ_02237 1048339.KB913029_gene2814 4.4e-18 99.4 Frankiales Bacteria 2GIVS@201174,4EW85@85013,COG1983@1,COG1983@2 NA|NA|NA KT PFAM PspC domain protein KOPIJCMJ_02239 1121946.AUAX01000003_gene1480 3.9e-234 817.4 Micromonosporales guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 iJN746.PP_1032,iSF_1195.SF2553,iSFxv_1172.SFxv_2808,iS_1188.S2725,iYL1228.KPN_02833 Bacteria 2GM09@201174,4DAVN@85008,COG0519@1,COG0519@2 NA|NA|NA F Catalyzes the synthesis of GMP from XMP KOPIJCMJ_02240 345341.KUTG_05928 5.2e-198 697.6 Pseudonocardiales choD GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009405,GO:0016491,GO:0016614,GO:0016899,GO:0016995,GO:0044419,GO:0051704,GO:0055114 1.1.3.6 ko:K03333 ko00984,ko01120,map00984,map01120 R01459 RC00146 ko00000,ko00001,ko01000 Bacteria 2GJ3J@201174,4DYHW@85010,COG2303@1,COG2303@2 NA|NA|NA E Catalyzes the oxidation and isomerization of cholesterol to cholestenone (4-cholesten-3-one), which is an initial step in the cholesterol degradation process. Required for virulence KOPIJCMJ_02241 1184609.KILIM_065_00100 2e-145 522.7 Dermatophilaceae gabD2 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009013,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016620,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0071944,GO:0072350 1.2.1.16,1.2.1.20,1.2.1.79,1.2.99.10 ko:K00135,ko:K22445 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ95@201174,4F6MX@85018,COG1012@1,COG1012@2 NA|NA|NA C Aldehyde dehydrogenase family KOPIJCMJ_02242 105420.BBPO01000010_gene2316 1.5e-146 526.6 Streptacidiphilus glpD 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 R00848 RC00029 ko00000,ko00001,ko01000 Bacteria 2GJKN@201174,2NHAR@228398,COG0578@1,COG0578@2 NA|NA|NA C C-terminal domain of alpha-glycerophosphate oxidase KOPIJCMJ_02243 105422.BBPM01000018_gene2466 9.1e-74 283.1 Streptacidiphilus guaB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GKVS@201174,2NH90@228398,COG0516@1,COG0516@2 NA|NA|NA F IMP dehydrogenase / GMP reductase domain KOPIJCMJ_02245 1172180.KB911793_gene3537 8.1e-107 393.7 Actinobacteria Bacteria 2GKRN@201174,COG2326@1,COG2326@2 NA|NA|NA G polyphosphate kinase KOPIJCMJ_02246 926560.KE387023_gene3341 9.5e-85 320.9 Deinococcus-Thermus cyp132 1.14.15.24 ko:K22492 ko00906,map00906 R07558,R07559,R09747 RC00478,RC02629 ko00000,ko00001,ko00199,ko01000 Bacteria 1WIX6@1297,COG2124@1,COG2124@2 NA|NA|NA Q cytochrome P450 KOPIJCMJ_02247 1306174.JODP01000006_gene3393 1.3e-28 132.9 Actinobacteria Bacteria 2IHPB@201174,COG0517@1,COG0517@2 NA|NA|NA S Cbs domain KOPIJCMJ_02248 235985.BBPN01000033_gene11 1.9e-65 256.1 Streptacidiphilus Bacteria 2GKUU@201174,2NH2E@228398,COG3173@1,COG3173@2 NA|NA|NA S Phosphotransferase enzyme family KOPIJCMJ_02250 1463841.JOIR01000009_gene4116 6.6e-78 297.4 Actinobacteria hisN GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.1.3.15 ko:K05602 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013 RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKZZ@201174,COG0483@1,COG0483@2 NA|NA|NA G inositol monophosphatase KOPIJCMJ_02252 590998.Celf_2198 6.1e-127 461.1 Cellulomonadaceae argE Bacteria 2GM84@201174,4F0HV@85016,COG0624@1,COG0624@2 NA|NA|NA E Peptidase dimerisation domain KOPIJCMJ_02253 1254432.SCE1572_32985 3.2e-29 136.7 Proteobacteria Bacteria 1N5ID@1224,COG3591@1,COG3591@2 NA|NA|NA E Belongs to the peptidase S1B family KOPIJCMJ_02255 998088.B565_2809 7.1e-36 158.3 Aeromonadales Bacteria 1NEEG@1224,1RZMD@1236,1Y4XF@135624,COG4938@1,COG4938@2 NA|NA|NA D AAA ATPase domain KOPIJCMJ_02256 1051006.HMPREF1162_1975 2.1e-27 128.3 Actinobacteria nuoI 1.6.5.3 ko:K00338,ko:K03615,ko:K05580 ko00190,ko01100,map00190,map01100 M00144,M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2GPSS@201174,COG1143@1,COG1143@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient KOPIJCMJ_02257 411471.SUBVAR_05270 2.1e-48 199.1 Ruminococcaceae pgp GO:0003674,GO:0003824,GO:0004672,GO:0004713,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018108,GO:0018193,GO:0018212,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046777,GO:0071704,GO:0140096,GO:1901564 3.1.3.18 ko:K01091,ko:K07025 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 R01334 RC00017 ko00000,ko00001,ko01000 Bacteria 1V1FQ@1239,24G1U@186801,3WITI@541000,COG0546@1,COG0546@2 NA|NA|NA S Psort location Cytoplasmic, score KOPIJCMJ_02258 1041522.MCOL_V200460 2.2e-58 231.9 Mycobacteriaceae trpF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 ko:K09767 ko00000 Bacteria 232N6@1762,2IFIU@201174,COG1666@1,COG1666@2 NA|NA|NA S Belongs to the UPF0234 family KOPIJCMJ_02262 351607.Acel_0287 5.1e-20 102.8 Frankiales rpmG ko:K02913 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GQFG@201174,4ETBC@85013,COG0267@1,COG0267@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL33 family KOPIJCMJ_02263 1304865.JAGF01000001_gene1598 1.2e-83 316.6 Actinobacteria fnt ko:K06212,ko:K21993 ko00000,ko02000 1.A.16.1.1,1.A.16.1.3,1.A.16.2 Bacteria 2I8DX@201174,COG2116@1,COG2116@2 NA|NA|NA P Formate nitrite transporter KOPIJCMJ_02265 196162.Noca_0672 7.9e-103 380.6 Propionibacteriales murB GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008360,GO:0008762,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0022603,GO:0022604,GO:0030203,GO:0034645,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045229,GO:0048037,GO:0050660,GO:0050662,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0055114,GO:0065007,GO:0065008,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 iECED1_1282.ECED1_4683,iECUMN_1333.ECUMN_4498_AT6,iLF82_1304.LF82_1416,iNRG857_1313.NRG857_19845 Bacteria 2GIV2@201174,4DNF7@85009,COG0812@1,COG0812@2 NA|NA|NA M Cell wall formation KOPIJCMJ_02266 105420.BBPO01000022_gene5822 7e-183 646.7 Streptacidiphilus aspC Bacteria 2GJ7R@201174,2NHQV@228398,COG0436@1,COG0436@2 NA|NA|NA E Cys/Met metabolism PLP-dependent enzyme KOPIJCMJ_02268 390989.JOEG01000009_gene1179 1.1e-10 72.4 Micromonosporales secE GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K03073 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 Bacteria 2GQFP@201174,4DF5J@85008,COG0690@1,COG0690@2 NA|NA|NA U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation KOPIJCMJ_02269 1123320.KB889574_gene5588 1.7e-71 276.2 Actinobacteria nusG GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0030312,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 ko:K02601 ko00000,ko03009,ko03021 Bacteria 2GJFW@201174,COG0250@1,COG0250@2 NA|NA|NA K Participates in transcription elongation, termination and antitermination KOPIJCMJ_02270 1155718.KB891885_gene6434 1.3e-62 245.7 Actinobacteria rplK GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010467,GO:0015934,GO:0015968,GO:0016043,GO:0019538,GO:0019843,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0032984,GO:0032991,GO:0033554,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0042594,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0051716,GO:0065003,GO:0070925,GO:0071496,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02867 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IFCK@201174,COG0080@1,COG0080@2 NA|NA|NA J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors KOPIJCMJ_02271 1089455.MOPEL_098_00060 1e-101 376.3 Dermatophilaceae rplA GO:0000027,GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006417,GO:0006446,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0017148,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045947,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 ko:K02863 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GM51@201174,4F6JF@85018,COG0081@1,COG0081@2 NA|NA|NA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release KOPIJCMJ_02272 367299.JOEE01000001_gene2148 1.4e-60 239.6 Intrasporangiaceae rplJ GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0017148,GO:0019222,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 ko:K02864,ko:K02935 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GM0V@201174,4FEG8@85021,COG0244@1,COG0244@2 NA|NA|NA J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors KOPIJCMJ_02273 298655.KI912266_gene338 1.4e-39 169.1 Frankiales rplL GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 ko:K02935 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IKNW@201174,4ESPE@85013,COG0222@1,COG0222@2 NA|NA|NA J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation KOPIJCMJ_02275 33876.JNXY01000009_gene9050 3.1e-163 581.3 Micromonosporales mmsA 1.2.1.18,1.2.1.27 ko:K00140 ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200 M00013 R00705,R00706,R00922,R00935 RC00004,RC02723,RC02817 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJI2@201174,4D8Q2@85008,COG1012@1,COG1012@2 NA|NA|NA C Aldehyde dehydrogenase family KOPIJCMJ_02276 1454010.JEOE01000007_gene2007 2.1e-85 322.8 Cellulomonadaceae 2.8.1.7,4.4.1.16 ko:K03980,ko:K11717 ko00450,ko01100,map00450,map01100 R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000,ko01011,ko02000 2.A.66.4 Bacteria 2I44K@201174,4F1AQ@85016,COG3266@1,COG3266@2 NA|NA|NA S domain, Protein KOPIJCMJ_02278 1487953.JMKF01000043_gene2606 2.7e-25 122.1 Cyanobacteria ko:K03712 ko00000,ko03000 Bacteria 1G8VK@1117,COG1846@1,COG1846@2 NA|NA|NA K helix_turn_helix multiple antibiotic resistance protein KOPIJCMJ_02279 1449058.JQKT01000007_gene1901 2.3e-170 605.1 Microbacteriaceae lys1 Bacteria 2GMQ1@201174,4FKWT@85023,COG1748@1,COG1748@2 NA|NA|NA E Saccharopine dehydrogenase C-terminal domain KOPIJCMJ_02280 521045.Kole_0725 1.9e-53 216.9 Thermotogae hemN1 Bacteria 2GDT0@200918,COG0635@1,COG0635@2 NA|NA|NA C Elongator protein 3, MiaB family, Radical SAM KOPIJCMJ_02281 1380347.JNII01000005_gene3136 1.1e-179 636.3 Frankiales gabT 2.6.1.19,2.6.1.22 ko:K00823,ko:K07250 ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648,R04188 RC00006,RC00062,RC00160 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 2GIS9@201174,4ERVR@85013,COG0160@1,COG0160@2 NA|NA|NA E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family KOPIJCMJ_02282 105422.BBPM01000100_gene5239 1.2e-181 642.9 Streptacidiphilus 1.2.1.3,1.2.1.9 ko:K00128,ko:K00131 ko00010,ko00030,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130,map01200 M00135,M00308,M00633 R00264,R00631,R00710,R00904,R01058,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIWZ@201174,2NG4B@228398,COG1012@1,COG1012@2 NA|NA|NA C Aldehyde dehydrogenase family KOPIJCMJ_02283 1440053.JOEI01000018_gene518 1.3e-147 529.6 Actinobacteria tyrS GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0030312,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 Bacteria 2GJPR@201174,COG0162@1,COG0162@2 NA|NA|NA J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) KOPIJCMJ_02284 1120950.KB892768_gene5196 5.8e-184 650.6 Propionibacteriales argH GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0030312,GO:0040007,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 iJN678.argH Bacteria 2GJ2A@201174,4DPEP@85009,COG0165@1,COG0165@2 NA|NA|NA E argininosuccinate lyase KOPIJCMJ_02285 1155718.KB891898_gene1918 7.5e-177 626.7 Actinobacteria argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0071944,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 iNJ661.Rv1658 Bacteria 2GK96@201174,COG0137@1,COG0137@2 NA|NA|NA E Belongs to the argininosuccinate synthase family. Type KOPIJCMJ_02286 1288083.AUKR01000003_gene3698 1.5e-43 182.6 Actinobacteria argR GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 ko:K03402 ko00000,ko03000 Bacteria 2GKA5@201174,COG1438@1,COG1438@2 NA|NA|NA K Regulates arginine biosynthesis genes KOPIJCMJ_02287 644283.Micau_2374 5e-128 464.5 Micromonosporales argD GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0008150,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 2GKE9@201174,4DBFJ@85008,COG4992@1,COG4992@2 NA|NA|NA E acetylornithine aminotransferase KOPIJCMJ_02288 28042.GU90_13915 7.8e-110 403.7 Pseudonocardiales argB GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0030312,GO:0031406,GO:0034618,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS10565,iJN678.argB,iLJ478.TM1784 Bacteria 2GKDS@201174,4DXB3@85010,COG0548@1,COG0548@2 NA|NA|NA E Belongs to the acetylglutamate kinase family. ArgB subfamily KOPIJCMJ_02289 1449353.JQMQ01000005_gene936 1.9e-145 522.3 Streptacidiphilus argJ GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35,2.7.2.8 ko:K00620,ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282,R02649 RC00002,RC00004,RC00043,RC00064 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIW0@201174,2NEHP@228398,COG1364@1,COG1364@2 NA|NA|NA E ArgJ family KOPIJCMJ_02290 351607.Acel_1263 1.9e-112 412.5 Frankiales argC GO:0000166,GO:0003674,GO:0005488,GO:0008150,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0048037,GO:0050661,GO:0050662,GO:0070401,GO:0097159,GO:1901265,GO:1901363 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKQK@201174,4ES9C@85013,COG0002@1,COG0002@2 NA|NA|NA E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde KOPIJCMJ_02291 1032480.MLP_44030 3.7e-171 608.2 Propionibacteriales Bacteria 2H32P@201174,4DX0H@85009,COG0477@1,COG2814@2 NA|NA|NA P Fungal trichothecene efflux pump (TRI12) KOPIJCMJ_02292 1123024.AUII01000002_gene940 5.5e-15 87.4 Pseudonocardiales Bacteria 2I8IW@201174,4EF3K@85010,COG1846@1,COG1846@2 NA|NA|NA K helix_turn_helix multiple antibiotic resistance protein KOPIJCMJ_02293 1122963.AUHB01000006_gene2514 8.9e-35 154.1 Alphaproteobacteria Bacteria 1N4Z9@1224,2UE0R@28211,COG1028@1,COG1028@2 NA|NA|NA IQ KR domain KOPIJCMJ_02294 269800.Tfu_2060 5e-260 904.0 Streptosporangiales pheT GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0019538,GO:0019752,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 2GMFD@201174,4EGYI@85012,COG0072@1,COG0072@2,COG0073@1,COG0073@2 NA|NA|NA J Ferredoxin-fold anticodon binding domain KOPIJCMJ_02295 1123320.KB889667_gene2923 9.9e-168 596.3 Actinobacteria pheS GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 2GJGG@201174,COG0016@1,COG0016@2 NA|NA|NA J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily KOPIJCMJ_02296 1307761.L21SP2_0103 1.4e-114 420.2 Spirochaetes GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.2.1.1 ko:K01176 ko00500,ko01100,ko04973,map00500,map01100,map04973 R02108,R02112,R11262 ko00000,ko00001,ko01000 GH13 iLJ478.TM1840 Bacteria 2J6AH@203691,COG0366@1,COG0366@2 NA|NA|NA G PFAM Alpha amylase, catalytic domain KOPIJCMJ_02297 1298863.AUEP01000012_gene3726 4.2e-54 218.4 Propionibacteriales tsnR 2.1.1.185 ko:K03218,ko:K03437 ko00000,ko01000,ko03009,ko03016 Bacteria 2GJI6@201174,4DQ6Y@85009,COG0566@1,COG0566@2 NA|NA|NA J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family KOPIJCMJ_02298 1283299.AUKG01000001_gene3305 1.1e-77 297.4 Actinobacteria 4.6.1.1 ko:K01768,ko:K17763 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000,ko03021 Bacteria 2IIRA@201174,COG2200@1,COG2200@2,COG2203@1,COG2203@2 NA|NA|NA T PFAM EAL domain protein KOPIJCMJ_02299 266940.Krad_3167 3.8e-47 194.1 Actinobacteria rplT GO:0000027,GO:0000900,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0060255,GO:0065003,GO:0065007,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090079,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2000113,GO:2001141 ko:K02887 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IHTN@201174,COG0292@1,COG0292@2 NA|NA|NA J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit KOPIJCMJ_02300 1122130.AUHN01000006_gene2126 8.5e-14 82.4 Actinobacteria rpmI GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 ko:K02916 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GQZW@201174,COG0291@1,COG0291@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL35 family KOPIJCMJ_02301 1184607.AUCHE_01_00170 1.7e-64 252.3 Dermatophilaceae infC GO:0000049,GO:0001731,GO:0002181,GO:0002183,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006417,GO:0006446,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016020,GO:0016043,GO:0019222,GO:0019538,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032268,GO:0032270,GO:0032790,GO:0032984,GO:0032988,GO:0032991,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043254,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045727,GO:0045948,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065003,GO:0065007,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901193,GO:1901195,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:1904688,GO:1904690,GO:1990856,GO:1990904,GO:2000112,GO:2000765,GO:2000767 ko:K02520 ko00000,ko03012,ko03029 Bacteria 2GJGT@201174,4F6SW@85018,COG0290@1,COG0290@2 NA|NA|NA J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins KOPIJCMJ_02302 452652.KSE_15250 1.2e-37 162.5 Kitasatospora Bacteria 2AI3Y@1,2IHSQ@201174,2M2YX@2063,318HW@2 NA|NA|NA KOPIJCMJ_02303 1123052.AUDF01000011_gene1510 6.1e-15 88.2 Microbacteriaceae hisA GO:0000105,GO:0003674,GO:0003824,GO:0003949,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.4.19,3.6.1.31,5.3.1.16,5.3.1.24 ko:K01814,ko:K01817,ko:K11755 ko00340,ko00400,ko01100,ko01110,ko01130,ko01230,map00340,map00400,map01100,map01110,map01130,map01230 M00023,M00026 R03509,R04035,R04037,R04640 RC00002,RC00945,RC01055 ko00000,ko00001,ko00002,ko01000 Bacteria 2I4YY@201174,4FKW9@85023,COG0106@1,COG0106@2 NA|NA|NA E SseB protein N-terminal domain KOPIJCMJ_02305 351607.Acel_0628 5.9e-158 563.9 Frankiales argS GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 iAF987.Gmet_1434 Bacteria 2GKQ3@201174,4ERR2@85013,COG0018@1,COG0018@2 NA|NA|NA J Arginyl-tRNA synthetase KOPIJCMJ_02306 2074.JNYD01000014_gene7070 3.1e-16 92.8 Pseudonocardiales ko:K07058 ko00000 Bacteria 2GM6P@201174,4E0J5@85010,COG1295@1,COG1295@2 NA|NA|NA S Virulence factor BrkB KOPIJCMJ_02307 1211815.CBYP010000042_gene2347 8.4e-159 567.0 Frankiales lysA 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKAI@201174,4ERM5@85013,COG0019@1,COG0019@2 NA|NA|NA E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine KOPIJCMJ_02308 222534.KB893751_gene4136 3.9e-131 474.9 Frankiales hom GO:0003674,GO:0003824,GO:0004412,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1294,iSB619.SA_RS06610 Bacteria 2GIX9@201174,4ERJB@85013,COG0460@1,COG0460@2 NA|NA|NA E homoserine dehydrogenase KOPIJCMJ_02309 1463920.JOGB01000028_gene5208 5.6e-139 500.7 Actinobacteria thrC GO:0003674,GO:0003824,GO:0004795,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 iLJ478.TM0546,iSB619.SA_RS06615,iYO844.BSU32250 Bacteria 2GJ5F@201174,COG0498@1,COG0498@2 NA|NA|NA E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine KOPIJCMJ_02310 593907.Celgi_2478 6.3e-67 261.2 Cellulomonadaceae thrB GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.1.39 ko:K00872 ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 M00018 R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 iECSE_1348.ECSE_0003,iJN678.thrB,iLJ478.TM0545,iSB619.SA_RS06620 Bacteria 2GKIW@201174,4F0RU@85016,COG0083@1,COG0083@2 NA|NA|NA E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate KOPIJCMJ_02311 680646.RMDY18_13030 1e-06 61.2 Bacteria Bacteria 28NAX@1,2ZBEI@2 NA|NA|NA KOPIJCMJ_02312 1108045.GORHZ_055_00070 1e-57 230.3 Actinobacteria ko:K07052 ko00000 Bacteria 2GREE@201174,COG1266@1,COG1266@2 NA|NA|NA S CAAX protease self-immunity KOPIJCMJ_02314 1137268.AZXF01000015_gene716 1.4e-63 249.2 Streptosporangiales Bacteria 2GJGZ@201174,4EH75@85012,COG1051@1,COG1051@2 NA|NA|NA F Domain of unknown function (DUF4916) KOPIJCMJ_02315 105420.BBPO01000009_gene2256 7.9e-151 540.4 Streptacidiphilus Bacteria 2GKKW@201174,2NHP9@228398,COG0624@1,COG0624@2 NA|NA|NA E Peptidase family M28 KOPIJCMJ_02316 479433.Caci_4794 1.4e-93 349.7 Actinobacteria Bacteria 2GMNA@201174,COG0667@1,COG0667@2 NA|NA|NA C aldo keto reductase KOPIJCMJ_02317 350054.Mflv_2213 1.1e-25 122.5 Mycobacteriaceae corA ko:K03284 ko00000,ko02000 1.A.35.1,1.A.35.3 Bacteria 235WH@1762,2GKNZ@201174,COG0598@1,COG0598@2 NA|NA|NA P Mediates influx of magnesium ions KOPIJCMJ_02319 1385518.N798_12655 4.8e-51 207.2 Intrasporangiaceae flpF ko:K02283 ko00000,ko02035,ko02044 Bacteria 2GKKJ@201174,4FE8N@85021,COG4962@1,COG4962@2 NA|NA|NA U pilus assembly protein ATPase CpaF KOPIJCMJ_02320 1132441.KI519455_gene3866 2.6e-67 261.9 Micrococcaceae ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 ko00000,ko00001,ko00002,ko02000 3.A.1.1 Bacteria 1W80X@1268,2GJCM@201174,COG3842@1,COG3842@2 NA|NA|NA E ABC transporter KOPIJCMJ_02322 1380347.JNII01000008_gene4187 2.6e-97 362.1 Frankiales aglG ko:K02026,ko:K10234 ko02010,map02010 M00201,M00207 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.32,3.A.1.1.8 Bacteria 2GJNN@201174,4EUW8@85013,COG0395@1,COG0395@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component KOPIJCMJ_02323 1380347.JNII01000008_gene4188 2.9e-102 378.6 Frankiales aglF ko:K02025,ko:K10233,ko:K15771 ko02010,map02010 M00201,M00207,M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.2,3.A.1.1.32,3.A.1.1.8 Bacteria 2GKYS@201174,4EV1G@85013,COG1175@1,COG1175@2 NA|NA|NA G Binding-protein-dependent transport system inner membrane component KOPIJCMJ_02324 1380347.JNII01000008_gene4189 4e-91 342.0 Frankiales ko:K10232 ko02010,map02010 M00201 ko00000,ko00001,ko00002,ko02000 3.A.1.1.32,3.A.1.1.8 Bacteria 2GJXB@201174,4ETQK@85013,COG1653@1,COG1653@2 NA|NA|NA G Bacterial extracellular solute-binding protein KOPIJCMJ_02325 408672.NBCG_01400 5.9e-71 275.0 Propionibacteriales 3.2.1.26 ko:K01193 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00801,R00802,R02410,R03635,R03921,R06088 RC00028,RC00077 ko00000,ko00001,ko01000 GH32 Bacteria 2GJ9T@201174,4DS6H@85009,COG1621@1,COG1621@2 NA|NA|NA G Glycosyl hydrolases family 32 KOPIJCMJ_02327 1449353.JQMQ01000004_gene6292 4.3e-81 308.5 Streptacidiphilus Bacteria 2GIZ3@201174,2NKDE@228398,COG1814@1,COG1814@2 NA|NA|NA S VIT family KOPIJCMJ_02328 1210046.B277_10139 5.4e-175 620.5 Intrasporangiaceae aat3 2.6.1.2,2.6.1.66 ko:K00814,ko:K14260 ko00220,ko00250,ko00290,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00220,map00250,map00290,map00710,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00171 R00258,R01215 RC00006,RC00008,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 2GJ7R@201174,4FFAU@85021,COG0436@1,COG0436@2 NA|NA|NA E in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor KOPIJCMJ_02330 1122622.ATWJ01000008_gene2889 6.6e-207 727.2 Intrasporangiaceae ams 2.4.1.4,3.2.1.1,5.4.99.16 ko:K05341,ko:K05343 ko00500,ko01100,map00500,map01100 R01557,R01823,R02108,R02112,R11262 RC00028,RC01816 ko00000,ko00001,ko01000 GH13 Bacteria 2GKT9@201174,4FEVJ@85021,COG0366@1,COG0366@2 NA|NA|NA G Alpha amylase, catalytic domain KOPIJCMJ_02331 1463861.JNXE01000006_gene5743 7e-43 180.3 Actinobacteria furA ko:K03711,ko:K22297 ko00000,ko03000 Bacteria 2IFBR@201174,COG0735@1,COG0735@2 NA|NA|NA P Belongs to the Fur family KOPIJCMJ_02332 1150399.AQYK01000001_gene1604 1.9e-231 809.3 Microbacteriaceae ko:K06994 ko00000 Bacteria 2GJ5A@201174,4FK7G@85023,COG1033@1,COG1033@2,COG2409@1,COG2409@2 NA|NA|NA D MMPL family KOPIJCMJ_02333 1032480.MLP_32170 8.3e-07 60.5 Bacteria ko:K03668,ko:K09914 ko00000 Bacteria COG3187@1,COG3187@2 NA|NA|NA O response to heat KOPIJCMJ_02335 1068978.AMETH_4863 6.2e-36 157.1 Pseudonocardiales fruA 2.7.1.202 ko:K02768,ko:K02769,ko:K02770,ko:K02806 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273 R03232 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1 Bacteria 2IMPP@201174,4E3T9@85010,COG1762@1,COG1762@2 NA|NA|NA G Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 KOPIJCMJ_02336 287986.DV20_35975 1.6e-75 289.7 Pseudonocardiales fruK GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006000,GO:0006001,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008443,GO:0008662,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019318,GO:0019320,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046835,GO:0071704,GO:1901575 2.7.1.11,2.7.1.56 ko:K00882,ko:K16370 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00345 R00756,R02071,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 iAF1260.b2168,iAPECO1_1312.APECO1_4386,iB21_1397.B21_02056,iEC042_1314.EC042_2401,iEC55989_1330.EC55989_2421,iECABU_c1320.ECABU_c24990,iECBD_1354.ECBD_1490,iECB_1328.ECB_02097,iECDH10B_1368.ECDH10B_2325,iECDH1ME8569_1439.ECDH1ME8569_2104,iECD_1391.ECD_02097,iECED1_1282.ECED1_2616,iECH74115_1262.ECH74115_3304,iECIAI1_1343.ECIAI1_2248,iECIAI39_1322.ECIAI39_2308,iECNA114_1301.ECNA114_2259,iECO103_1326.ECO103_2643,iECO111_1330.ECO111_2886,iECO26_1355.ECO26_3080,iECOK1_1307.ECOK1_2400,iECP_1309.ECP_2208,iECS88_1305.ECS88_2316,iECSE_1348.ECSE_2436,iECSF_1327.ECSF_2049,iECSP_1301.ECSP_3046,iECUMN_1333.ECUMN_2504,iECW_1372.ECW_m2369,iECs_1301.ECs3060,iEKO11_1354.EKO11_1586,iETEC_1333.ETEC_2303,iEcDH1_1363.EcDH1_1490,iEcHS_1320.EcHS_A2305,iEcSMS35_1347.EcSMS35_2315,iEcolC_1368.EcolC_1480,iG2583_1286.G2583_2711,iJO1366.b2168,iJR904.b2168,iLF82_1304.LF82_0744,iNRG857_1313.NRG857_11005,iPC815.YPO1299,iSBO_1134.SBO_2156,iSDY_1059.SDY_2316,iSFV_1184.SFV_2243,iSF_1195.SF2253,iSFxv_1172.SFxv_2486,iS_1188.S2382,iUMN146_1321.UM146_05955,iUMNK88_1353.UMNK88_2713,iUTI89_1310.UTI89_C2443,iWFL_1372.ECW_m2369,iY75_1357.Y75_RS11345,iZ_1308.Z3426,ic_1306.c2703 Bacteria 2GK7E@201174,4E1A9@85010,COG1105@1,COG1105@2 NA|NA|NA H Belongs to the carbohydrate kinase PfkB family KOPIJCMJ_02337 28444.JODQ01000007_gene5740 1.7e-78 299.3 Streptosporangiales ko:K02081,ko:K03436 ko00000,ko03000 Bacteria 2GKWM@201174,4EHNG@85012,COG1349@1,COG1349@2 NA|NA|NA K DeoR C terminal sensor domain KOPIJCMJ_02338 1504319.GM45_0745 2.7e-56 225.7 unclassified Actinobacteria (class) ko:K02029,ko:K02030 M00236 ko00000,ko00002,ko02000 3.A.1.3 Bacteria 2HFUI@201174,3UXRH@52018,COG0834@1,COG0834@2 NA|NA|NA ET Bacterial periplasmic substrate-binding proteins KOPIJCMJ_02340 1160718.SU9_05021 7.1e-95 353.6 Actinobacteria prpE 6.2.1.1,6.2.1.17 ko:K01895,ko:K01908 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 2GP7N@201174,COG0365@1,COG0365@2 NA|NA|NA I PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A KOPIJCMJ_02341 648757.Rvan_0038 9.1e-75 287.0 Alphaproteobacteria 1.3.7.8 ko:K04113 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R02451 RC00002,RC01839 ko00000,ko00001,ko00002,ko01000 Bacteria 1NKED@1224,2U31W@28211,COG1775@1,COG1775@2 NA|NA|NA E benzoyl-CoA reductase KOPIJCMJ_02346 1095767.CAHD01000224_gene2103 1.4e-223 782.3 Cellulomonadaceae rnj GO:0003674,GO:0005488,GO:0005515,GO:0042802 ko:K12574 ko03018,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 2GIW7@201174,4F0MZ@85016,COG0595@1,COG0595@2 NA|NA|NA S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay KOPIJCMJ_02348 656024.FsymDg_1517 0.0 1082.0 Frankiales ko:K03727 ko00000,ko01000 Bacteria 2GJSV@201174,4ES27@85013,COG4581@1,COG4581@2 NA|NA|NA L DEAD DEAH box helicase KOPIJCMJ_02352 1435356.Y013_26415 0.0 1196.0 Nocardiaceae Bacteria 2HG4J@201174,4G07P@85025,COG1483@1,COG1483@2 NA|NA|NA S Protein of unknown function (DUF499) KOPIJCMJ_02353 479434.Sthe_2828 8.6e-12 77.0 Bacteria Bacteria 2ZF74@2,arCOG11351@1 NA|NA|NA KOPIJCMJ_02354 1229781.C272_01170 4.2e-298 1030.8 Actinobacteria rsmJ 2.1.1.242 ko:K15984 ko00000,ko01000,ko03009 Bacteria 2GN2Y@201174,COG1743@1,COG1743@2 NA|NA|NA L DNA methylAse KOPIJCMJ_02357 1122609.AUGT01000023_gene513 4.6e-126 457.6 Propionibacteriales phoH GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K06217 ko00000 Bacteria 2GK0W@201174,4DPI2@85009,COG1702@1,COG1702@2 NA|NA|NA T PhoH-like protein KOPIJCMJ_02358 570268.ANBB01000046_gene1392 8.7e-46 189.9 Streptosporangiales ybeY GO:0000469,GO:0000478,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006355,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016072,GO:0016151,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0019219,GO:0019222,GO:0019538,GO:0022613,GO:0030490,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043244,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141 2.6.99.2,3.5.4.5 ko:K01489,ko:K03474,ko:K03595,ko:K07042 ko00240,ko00750,ko00983,ko01100,map00240,map00750,map00983,map01100 M00124 R01878,R02485,R05838,R08221 RC00074,RC00514,RC01476 ko00000,ko00001,ko00002,ko01000,ko03009,ko03029 Bacteria 2GMUF@201174,4EIYX@85012,COG0319@1,COG0319@2 NA|NA|NA S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA KOPIJCMJ_02359 1120936.KB907220_gene1928 1.6e-119 436.4 Streptosporangiales corC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 2GIWR@201174,4EFYG@85012,COG1253@1,COG1253@2 NA|NA|NA S Transporter associated domain KOPIJCMJ_02360 1463856.JOHY01000067_gene7125 3.7e-115 421.4 Actinobacteria era GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043021,GO:0043024,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070181,GO:0070925,GO:0071826,GO:0071840,GO:0097159,GO:1901363 ko:K03595 ko00000,ko03009,ko03029 Bacteria 2GJJE@201174,COG1159@1,COG1159@2 NA|NA|NA M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism KOPIJCMJ_02361 526225.Gobs_3844 4.5e-141 508.1 Frankiales deaD 3.6.4.13 ko:K05592,ko:K11927 ko03018,map03018 ko00000,ko00001,ko01000,ko03009,ko03019 Bacteria 2GIUR@201174,4ES4U@85013,COG0513@1,COG0513@2 NA|NA|NA L DEAD DEAH box helicase domain protein KOPIJCMJ_02362 1386089.N865_12655 7.1e-82 311.2 Intrasporangiaceae Bacteria 2GN4Y@201174,4FF71@85021,COG0628@1,COG0628@2 NA|NA|NA S AI-2E family transporter KOPIJCMJ_02363 471853.Bcav_1766 2.9e-83 315.1 Actinobacteria recO GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 ko:K03584 ko03440,map03440 ko00000,ko00001,ko03400 Bacteria 2GK81@201174,COG1381@1,COG1381@2 NA|NA|NA L Involved in DNA repair and RecF pathway recombination KOPIJCMJ_02364 397278.JOJN01000001_gene3042 7.3e-28 130.6 Propionibacteriales Bacteria 2GWCE@201174,4DV6A@85009,COG2453@1,COG2453@2 NA|NA|NA T Dual specificity phosphatase, catalytic domain KOPIJCMJ_02365 58123.JOFJ01000001_gene3316 7.3e-118 430.3 Streptosporangiales uppS GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008834,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0050347,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617 2.5.1.31,2.5.1.86,2.5.1.88 ko:K00806,ko:K14215,ko:K21273 ko00900,ko01110,map00900,map01110 R06447,R09244,R09731 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 Bacteria 2GIXF@201174,4EG00@85012,COG0020@1,COG0020@2 NA|NA|NA I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids KOPIJCMJ_02367 1504319.GM45_0330 1.3e-225 788.9 unclassified Actinobacteria (class) glyQS GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009345,GO:0009987,GO:0010467,GO:0016070,GO:0016594,GO:0016597,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0042165,GO:0042802,GO:0042803,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046983,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.14 ko:K01880 ko00970,map00970 M00359,M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 iSB619.SA_RS07880 Bacteria 2GIT3@201174,3UW9K@52018,COG0423@1,COG0423@2 NA|NA|NA J Catalyzes the attachment of glycine to tRNA(Gly) KOPIJCMJ_02369 1048339.KB913029_gene4777 9.7e-128 463.4 Frankiales dus Bacteria 2GJ8I@201174,4ERGB@85013,COG0042@1,COG0042@2 NA|NA|NA J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines KOPIJCMJ_02370 1504822.CCNO01000011_gene176 5.1e-97 361.7 unclassified Bacteria malS 3.2.1.1 ko:K01176 ko00500,ko01100,ko04973,map00500,map01100,map04973 R02108,R02112,R11262 ko00000,ko00001,ko01000 GH13 Bacteria 2NPAG@2323,COG0366@1,COG0366@2 NA|NA|NA G PFAM Alpha amylase, catalytic KOPIJCMJ_02371 1160137.KB907307_gene3773 1.7e-160 572.8 Nocardiaceae aglA 3.2.1.10,3.2.1.20,3.2.1.93 ko:K01182,ko:K01187,ko:K01226 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00028,R00801,R00802,R00837,R01718,R01791,R06087,R06088,R06113,R06199 RC00028,RC00049,RC00059,RC00077,RC00451 ko00000,ko00001,ko01000 GH13,GH31 Bacteria 2GKS4@201174,4FUMW@85025,COG0366@1,COG0366@2 NA|NA|NA G Alpha-amylase domain KOPIJCMJ_02375 253839.SSNG_04680 7.3e-52 210.3 Actinobacteria Bacteria 2GJRV@201174,COG4420@1,COG4420@2 NA|NA|NA S membrane KOPIJCMJ_02376 351607.Acel_1818 8.9e-109 400.6 Frankiales mgtE Bacteria 2GMMK@201174,4ERJN@85013,COG2239@1,COG2239@2 NA|NA|NA P CBS domain KOPIJCMJ_02377 1283283.ATXA01000005_gene2174 3.3e-68 265.4 Frankiales Bacteria 2I198@201174,4ESMN@85013,COG0697@1,COG0697@2 NA|NA|NA EG EamA-like transporter family KOPIJCMJ_02378 1048339.KB913029_gene2897 2.2e-147 528.5 Frankiales mcl1 4.1.3.24,4.1.3.25,4.1.3.34,5.4.99.63 ko:K01644,ko:K08691,ko:K14447,ko:K18292 ko00630,ko00660,ko00680,ko00720,ko01100,ko01120,ko01200,ko02020,map00630,map00660,map00680,map00720,map01100,map01120,map01200,map02020 M00346,M00373,M00376 R00237,R00362,R00473,R00934,R09292 RC00067,RC00307,RC00308,RC00311,RC00407,RC00502,RC01118,RC01205,RC02835 ko00000,ko00001,ko00002,ko01000 Bacteria 2GK5J@201174,4ESAE@85013,COG0697@1,COG0697@2,COG2301@1,COG2301@2 NA|NA|NA G Belongs to the HpcH HpaI aldolase family KOPIJCMJ_02382 1288083.AUKR01000014_gene2876 5e-109 402.1 Actinobacteria Bacteria 2GKI5@201174,COG1835@1,COG1835@2 NA|NA|NA I Acyltransferase KOPIJCMJ_02383 469371.Tbis_2812 3.9e-134 484.6 Pseudonocardiales leuB GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044464,GO:0055114 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GK44@201174,4DXBP@85010,COG0473@1,COG0473@2 NA|NA|NA CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate KOPIJCMJ_02384 1123322.KB904660_gene1100 1.7e-141 509.2 Actinobacteria ilvE GO:0000082,GO:0000096,GO:0000097,GO:0000278,GO:0003674,GO:0003824,GO:0004084,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0006082,GO:0006464,GO:0006520,GO:0006551,GO:0006555,GO:0006573,GO:0006790,GO:0006807,GO:0007049,GO:0008144,GO:0008150,GO:0008152,GO:0008283,GO:0008483,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009067,GO:0009081,GO:0009082,GO:0009083,GO:0009086,GO:0009098,GO:0009099,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016769,GO:0017144,GO:0018065,GO:0018193,GO:0018205,GO:0018272,GO:0018352,GO:0019538,GO:0019752,GO:0019842,GO:0022402,GO:0030170,GO:0036094,GO:0036211,GO:0040007,GO:0043094,GO:0043102,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044770,GO:0044772,GO:0044843,GO:0046394,GO:0046395,GO:0048037,GO:0050662,GO:0070279,GO:0071265,GO:0071267,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901607,GO:1903047 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 2GKJ1@201174,COG0115@1,COG0115@2 NA|NA|NA E Branched-chain amino acid aminotransferase KOPIJCMJ_02386 1869.MB27_31595 1.9e-98 365.9 Micromonosporales f42a Bacteria 2GM0Z@201174,4DBBQ@85008,COG0330@1,COG0330@2 NA|NA|NA O prohibitin homologues KOPIJCMJ_02387 1435356.Y013_20760 3.3e-19 100.9 Nocardiaceae Bacteria 2GQV1@201174,4G3V1@85025,COG4877@1,COG4877@2 NA|NA|NA KOPIJCMJ_02390 1077972.ARGLB_029_00020 4.8e-11 75.1 Bacteria Bacteria 2ECD9@1,31QH2@2 NA|NA|NA KOPIJCMJ_02391 935866.JAER01000004_gene3859 1.6e-37 161.8 Propionibacteriales Bacteria 2E5NA@1,2IQ91@201174,330D3@2,4DRUP@85009 NA|NA|NA S Domain of unknown function (DUF4287) KOPIJCMJ_02392 765911.Thivi_2384 4.9e-23 115.2 Chromatiales MA20_05910 ko:K03668,ko:K09914 ko00000 Bacteria 1NGG1@1224,1S7JT@1236,1WYQQ@135613,COG3187@1,COG3187@2 NA|NA|NA O META domain KOPIJCMJ_02393 67267.JNXT01000003_gene4090 1.8e-09 68.6 Actinobacteria Bacteria 2B1UQ@1,2GTR9@201174,31UAQ@2 NA|NA|NA KOPIJCMJ_02394 1280390.CBQR020000100_gene2320 3.2e-90 338.6 Paenibacillaceae Bacteria 1TSWF@1239,274FR@186822,4HANV@91061,COG0604@1,COG0604@2 NA|NA|NA C Zinc-binding dehydrogenase KOPIJCMJ_02395 543632.JOJL01000004_gene4174 3.7e-34 152.1 Micromonosporales Bacteria 2EJNG@1,2H04Y@201174,33DDC@2,4DM96@85008 NA|NA|NA S Domain of unknown function (DUF4386) KOPIJCMJ_02396 1172188.KB911822_gene695 2.9e-15 87.8 Intrasporangiaceae Bacteria 2DNVA@1,2GRAT@201174,32ZBE@2,4FJSY@85021 NA|NA|NA KOPIJCMJ_02397 42256.RradSPS_0358 1.7e-205 723.0 Rubrobacteria ko:K03556 ko00000,ko03000 Bacteria 2HENR@201174,4CPC9@84995,COG2909@1,COG2909@2 NA|NA|NA K helix_turn_helix, Lux Regulon KOPIJCMJ_02398 469371.Tbis_3586 1.8e-16 92.4 Actinobacteria Bacteria 2B9QR@1,2H7N9@201174,3233A@2 NA|NA|NA KOPIJCMJ_02399 211114.JOEF01000049_gene5388 2e-10 72.4 Pseudonocardiales Bacteria 2B67R@1,2HS99@201174,31Z4Y@2,4ECXR@85010 NA|NA|NA KOPIJCMJ_02400 356851.JOAN01000015_gene2407 1.8e-15 89.4 Micromonosporales Bacteria 2EBG5@1,2GRUT@201174,335GQ@2,4DFPV@85008 NA|NA|NA KOPIJCMJ_02401 479431.Namu_3385 2.2e-74 285.8 Frankiales ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GMJD@201174,4EV32@85013,COG1277@1,COG1277@2 NA|NA|NA S ABC-2 family transporter protein KOPIJCMJ_02402 526225.Gobs_2016 2.1e-118 432.2 Frankiales ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GJDP@201174,4EUYH@85013,COG1131@1,COG1131@2 NA|NA|NA V PFAM ABC transporter related KOPIJCMJ_02403 649831.L083_5013 1.1e-17 95.1 Actinobacteria Bacteria 2GJ46@201174,COG2197@1,COG2197@2 NA|NA|NA T response regulator KOPIJCMJ_02404 467200.ACFA01000086_gene1346 1.4e-222 779.2 Actinobacteria acsA 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 2GNE8@201174,COG0365@1,COG0365@2 NA|NA|NA I synthetase KOPIJCMJ_02405 1123065.ATWL01000009_gene974 4.8e-50 204.1 Actinobacteria 3.6.1.55 ko:K03574 ko00000,ko01000,ko03400 Bacteria 2IKKB@201174,COG1051@1,COG1051@2 NA|NA|NA F Nudix hydrolase KOPIJCMJ_02407 103733.JNYO01000008_gene5422 3.2e-46 192.6 Pseudonocardiales Bacteria 2GKAY@201174,4E36B@85010,COG5012@1,COG5012@2 NA|NA|NA S cobalamin binding protein KOPIJCMJ_02408 479435.Kfla_5843 1.2e-76 292.7 Propionibacteriales nth 4.2.99.18 ko:K07457,ko:K10773 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 2GNE5@201174,4DQDJ@85009,COG0177@1,COG0177@2 NA|NA|NA L HhH-GPD superfamily base excision DNA repair protein KOPIJCMJ_02410 1121106.JQKB01000013_gene5441 1.2e-07 63.9 Alphaproteobacteria Bacteria 1QW7K@1224,2U79M@28211,COG2197@1,COG2197@2 NA|NA|NA K helix_turn_helix, Lux Regulon KOPIJCMJ_02411 1280946.HY29_18285 1.6e-36 160.2 Alphaproteobacteria Bacteria 1NPD3@1224,2UX3E@28211,COG2850@1,COG2850@2 NA|NA|NA S Cupin superfamily protein KOPIJCMJ_02412 1231391.AMZF01000003_gene3115 2.6e-50 205.7 Alcaligenaceae Bacteria 1N3A2@1224,2W95G@28216,3T7RQ@506,COG1028@1,COG1028@2 NA|NA|NA IQ KR domain KOPIJCMJ_02413 1352941.M877_37700 1e-30 141.4 Actinobacteria sagD ko:K09136 ko00000,ko03009 Bacteria 2GKBS@201174,COG1944@1,COG1944@2 NA|NA|NA S YcaO cyclodehydratase, ATP-ad Mg2+-binding KOPIJCMJ_02415 1278073.MYSTI_04797 4.8e-63 248.8 Deltaproteobacteria hemN GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 Bacteria 1MU76@1224,2WIM5@28221,42NGU@68525,COG0635@1,COG0635@2 NA|NA|NA H Involved in the biosynthesis of porphyrin-containing compound KOPIJCMJ_02416 318586.Pden_4195 8e-32 144.4 Alphaproteobacteria sagB Bacteria 1PUI1@1224,2U13C@28211,COG0778@1,COG0778@2 NA|NA|NA C Nitroreductase family KOPIJCMJ_02419 1380386.JIAW01000001_gene4637 2.5e-105 389.0 Mycobacteriaceae tdt Bacteria 2357X@1762,2GKPA@201174,COG1275@1,COG1275@2 NA|NA|NA P C4-dicarboxylate transporter malic acid transport protein KOPIJCMJ_02420 1120936.KB907215_gene4139 1.1e-89 337.0 Streptosporangiales pstS GO:0002682,GO:0002683,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009607,GO:0009987,GO:0009991,GO:0015698,GO:0016020,GO:0016036,GO:0030312,GO:0031347,GO:0031348,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0035821,GO:0040007,GO:0042594,GO:0043207,GO:0044003,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044413,GO:0044414,GO:0044419,GO:0044464,GO:0045088,GO:0045824,GO:0048519,GO:0048583,GO:0048585,GO:0050776,GO:0050777,GO:0050789,GO:0050896,GO:0051179,GO:0051234,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051817,GO:0051832,GO:0051833,GO:0052031,GO:0052037,GO:0052167,GO:0052170,GO:0052173,GO:0052200,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0065007,GO:0071496,GO:0071944,GO:0075136,GO:0080134 ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 ko00000,ko00001,ko00002,ko02000 3.A.1.7 Bacteria 2GJXD@201174,4EGMU@85012,COG0226@1,COG0226@2 NA|NA|NA P Part of the ABC transporter complex PstSACB involved in phosphate import KOPIJCMJ_02421 1957.JODX01000009_gene2682 7.5e-95 354.0 Actinobacteria pstC GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0009314,GO:0009628,GO:0010921,GO:0015698,GO:0016020,GO:0016021,GO:0019220,GO:0019222,GO:0031224,GO:0031226,GO:0031323,GO:0034220,GO:0035303,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0055085,GO:0065007,GO:0065009,GO:0071944,GO:0098656,GO:0098660,GO:0098661 ko:K02037,ko:K02038 ko02010,map02010 M00222 ko00000,ko00001,ko00002,ko02000 3.A.1.7 iAF987.Gmet_2702,ic_1306.c4652 Bacteria 2GJDA@201174,COG0573@1,COG0573@2 NA|NA|NA P probably responsible for the translocation of the substrate across the membrane KOPIJCMJ_02422 1172179.AUKV01000029_gene7734 1.9e-91 342.8 Actinobacteria pstA GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0010921,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0019220,GO:0019222,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0031323,GO:0033554,GO:0034220,GO:0035303,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0051716,GO:0055085,GO:0065007,GO:0065009,GO:0071944,GO:0098656,GO:0098660,GO:0098661 ko:K02037,ko:K02038 ko02010,map02010 M00222 ko00000,ko00001,ko00002,ko02000 3.A.1.7 iJN746.PP_2658,iPC815.YPO4115,iYL1228.KPN_04131,iZ_1308.Z5217 Bacteria 2I2F2@201174,COG0581@1,COG0581@2 NA|NA|NA P phosphate transport system permease KOPIJCMJ_02423 208439.AJAP_40425 2.5e-51 208.4 Pseudonocardiales pstB 3.6.3.27 ko:K02036 ko02010,map02010 M00222 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 Bacteria 2GJQ3@201174,4DY3N@85010,COG1117@1,COG1117@2 NA|NA|NA P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system KOPIJCMJ_02424 1156844.KB891814_gene6810 3.7e-42 178.3 Actinobacteria alkD Bacteria 2GNQD@201174,COG4912@1,COG4912@2 NA|NA|NA L DNA alkylation repair KOPIJCMJ_02425 1148.1652140 1.1e-174 619.8 Synechocystis gadB 4.1.1.15 ko:K01580 ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940 M00027 R00261,R00489,R01682,R02466 RC00299 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv3432c Bacteria 1G47D@1117,1H682@1142,COG0076@1,COG0076@2 NA|NA|NA E Pyridoxal-dependent decarboxylase conserved domain KOPIJCMJ_02426 1298863.AUEP01000001_gene1023 1.9e-99 369.0 Propionibacteriales Bacteria 2I8NG@201174,30Y0T@2,4DW1P@85009,arCOG10607@1 NA|NA|NA KOPIJCMJ_02427 1121920.AUAU01000018_gene1775 2e-16 92.4 Acidobacteria Bacteria 3Y4HW@57723,COG2318@1,COG2318@2 NA|NA|NA S Mycothiol maleylpyruvate isomerase N-terminal domain KOPIJCMJ_02428 404589.Anae109_3092 6.6e-17 95.9 Proteobacteria Bacteria 1N29G@1224,COG3568@1,COG3568@2 NA|NA|NA S Endonuclease/Exonuclease/phosphatase family KOPIJCMJ_02430 452652.KSE_07440 1.2e-25 124.4 Actinobacteria 2.1.1.107 ko:K02303,ko:K22010 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121,M00839 R03194 RC00003,RC00871 ko00000,ko00001,ko00002,ko01000,ko02022 Bacteria 2GKG3@201174,COG2203@1,COG2203@2,COG2208@1,COG2208@2,COG3707@1,COG3707@2 NA|NA|NA KT phosphatase KOPIJCMJ_02432 1123020.AUIE01000023_gene5023 9.2e-10 69.3 Bacteria Bacteria COG0236@1,COG0236@2 NA|NA|NA IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis KOPIJCMJ_02433 1121272.KB903290_gene4656 2.4e-60 238.8 Micromonosporales aceF 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GN5J@201174,4DIEJ@85008,COG0508@1,COG0508@2 NA|NA|NA C e3 binding domain KOPIJCMJ_02435 33898.JRHJ01000076_gene172 2.7e-46 191.4 Actinobacteria ko:K04750 ko00000 Bacteria 2IKY5@201174,COG2764@1,COG2764@2 NA|NA|NA S glyoxalase bleomycin resistance protein dioxygenase KOPIJCMJ_02436 314345.SPV1_05173 2.9e-95 355.9 Proteobacteria Bacteria 1NV1F@1224,COG2199@1,COG2199@2 NA|NA|NA T ggdef domain KOPIJCMJ_02437 43354.JOIJ01000011_gene2664 1.3e-120 440.7 Pseudonocardiales Bacteria 2GKI5@201174,4DYJ7@85010,COG1835@1,COG1835@2 NA|NA|NA I PFAM Acyltransferase KOPIJCMJ_02438 1121385.AQXW01000004_gene2438 7.4e-61 240.4 Dermacoccaceae acd Bacteria 1ZVGY@145357,2GJIB@201174,COG1960@1,COG1960@2 NA|NA|NA C Acyl-CoA dehydrogenase N terminal KOPIJCMJ_02439 1896.JOAU01000002_gene4042 3.1e-75 288.5 Actinobacteria mtnU ko:K11206 ko00000,ko01000 Bacteria 2GMQA@201174,COG0388@1,COG0388@2 NA|NA|NA E Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase KOPIJCMJ_02440 1172179.AUKV01000016_gene2208 5.1e-189 667.5 Actinobacteria Bacteria 2I7MG@201174,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily KOPIJCMJ_02441 1122609.AUGT01000009_gene3024 1.1e-18 99.0 Propionibacteriales Bacteria 2IR0P@201174,4DS21@85009,COG0695@1,COG0695@2 NA|NA|NA O Glutaredoxin-like domain (DUF836) KOPIJCMJ_02442 1122182.KB903813_gene2267 1.5e-118 433.3 Micromonosporales 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 Bacteria 2GIUC@201174,4DBR0@85008,COG0318@1,COG0318@2 NA|NA|NA IQ AMP-binding enzyme C-terminal domain KOPIJCMJ_02443 44060.JODL01000048_gene1559 2.3e-72 279.3 Actinobacteria serB1 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K21830 ko00000 Bacteria 2GJW9@201174,COG0560@1,COG0560@2 NA|NA|NA E HAD-superfamily subfamily IB hydrolase, TIGR01490 KOPIJCMJ_02444 1246995.AFR_08775 1.1e-64 253.4 Micromonosporales ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2ID14@201174,4DCGZ@85008,COG1277@1,COG1277@2 NA|NA|NA S ABC-2 family transporter protein KOPIJCMJ_02445 1122182.KB903837_gene3906 4.3e-95 354.8 Micromonosporales ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GKEH@201174,4D8QU@85008,COG1131@1,COG1131@2 NA|NA|NA V AAA domain, putative AbiEii toxin, Type IV TA system KOPIJCMJ_02446 28042.GU90_05920 1.3e-109 402.9 Pseudonocardiales GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 2GJKH@201174,4E0YI@85010,COG0204@1,COG0204@2 NA|NA|NA I Acyltransferase KOPIJCMJ_02447 1120950.KB892801_gene1769 1.9e-109 402.5 Propionibacteriales galE2 GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv0501 Bacteria 2GNT1@201174,4DPEE@85009,COG0451@1,COG0451@2 NA|NA|NA GM GDP-mannose 4,6 dehydratase KOPIJCMJ_02448 471852.Tcur_4450 4.5e-18 96.7 Streptosporangiales xis Bacteria 2GQGV@201174,4EKJX@85012,COG3311@1,COG3311@2 NA|NA|NA K Helix-turn-helix domain KOPIJCMJ_02449 28444.JODQ01000014_gene6728 3.6e-131 474.9 Streptosporangiales acuC ko:K04768 ko00000 iYO844.BSU29710 Bacteria 2GJUH@201174,4EGFY@85012,COG0123@1,COG0123@2 NA|NA|NA BQ Histone deacetylase domain KOPIJCMJ_02450 1385519.N801_08350 3.7e-102 379.0 Intrasporangiaceae trkH ko:K03498 ko00000,ko02000 2.A.38.1,2.A.38.4 Bacteria 2GKKS@201174,4FG5M@85021,COG0168@1,COG0168@2 NA|NA|NA P Cation transport protein KOPIJCMJ_02451 35754.JNYJ01000053_gene6709 5.5e-41 174.5 Micromonosporales trkA ko:K03499 ko00000,ko02000 2.A.38.1,2.A.38.4 Bacteria 2IA09@201174,4DCSC@85008,COG0569@1,COG0569@2 NA|NA|NA P TrkA-C domain KOPIJCMJ_02452 1306174.JODP01000006_gene3453 1.4e-70 273.1 Actinobacteria proC GO:0000287,GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0030145,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ7D@201174,COG0345@1,COG0345@2 NA|NA|NA E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline KOPIJCMJ_02453 1048339.KB913029_gene2309 1.2e-41 177.2 Frankiales ko:K00318 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 R10507 RC00083 ko00000,ko00001,ko01000 Bacteria 2GJTK@201174,4ERCN@85013,COG0506@1,COG0506@2 NA|NA|NA E Proline dehydrogenase KOPIJCMJ_02454 931627.MycrhDRAFT_6074 2.4e-64 252.7 Mycobacteriaceae Bacteria 23CKA@1762,2GKPS@201174,COG4850@1,COG4850@2 NA|NA|NA S Uncharacterized conserved protein (DUF2183) KOPIJCMJ_02456 1385519.N801_00635 1.2e-82 313.5 Intrasporangiaceae Bacteria 2GIS3@201174,4FGCG@85021,COG0604@1,COG0604@2 NA|NA|NA C Zinc-binding dehydrogenase KOPIJCMJ_02458 479433.Caci_7815 8.4e-181 639.8 Actinobacteria moeB GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008146,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0016782,GO:0019344,GO:0019752,GO:0020012,GO:0030312,GO:0030682,GO:0042783,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071704,GO:0071944,GO:0075136,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.80,2.8.1.11,3.1.2.6 ko:K01069,ko:K21029,ko:K21147 ko00620,ko04122,map00620,map04122 R01736,R07459,R07461 RC00004,RC00043,RC00137 ko00000,ko00001,ko01000 Bacteria 2GJB6@201174,COG0476@1,COG0476@2,COG0607@1,COG0607@2 NA|NA|NA H The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are KOPIJCMJ_02459 479432.Sros_8912 8.9e-25 119.4 Streptosporangiales 2.7.7.80,2.8.1.11 ko:K03636,ko:K21147 ko04122,map04122 R07459,R07461 RC00043 ko00000,ko00001,ko01000 Bacteria 2IQBT@201174,4EKIY@85012,COG1977@1,COG1977@2 NA|NA|NA H ThiS family KOPIJCMJ_02460 1123320.KB889748_gene4519 7.9e-156 557.0 Actinobacteria thrC1 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 Bacteria 2GNM0@201174,COG0498@1,COG0498@2 NA|NA|NA E Threonine synthase KOPIJCMJ_02461 313589.JNB_13298 1.6e-95 356.3 Intrasporangiaceae 3.2.1.26 ko:K01193 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00801,R00802,R02410,R03635,R03921,R06088 RC00028,RC00077 ko00000,ko00001,ko01000 GH32 Bacteria 2H3S0@201174,4FEDK@85021,COG1621@1,COG1621@2 NA|NA|NA G Glycosyl hydrolase family 32 KOPIJCMJ_02462 593907.Celgi_0422 1.8e-31 141.7 Cellulomonadaceae Bacteria 2CUM0@1,2IQG7@201174,32SVJ@2,4F1EW@85016 NA|NA|NA S Protein of unknown function (DUF3263) KOPIJCMJ_02463 1048339.KB913029_gene2124 1.2e-82 313.5 Frankiales gpgS 2.4.1.266,2.4.1.268 ko:K13693,ko:K21349 ko00000,ko01000,ko01003 GT81 Bacteria 2GMKV@201174,4ES7J@85013,COG1215@1,COG1215@2 NA|NA|NA M Glycosyltransferase like family 2 KOPIJCMJ_02464 136273.GY22_15155 4.2e-26 124.4 Micrococcaceae Bacteria 1W9Y1@1268,2CR5C@1,2IT0H@201174,32SNF@2 NA|NA|NA KOPIJCMJ_02465 1121946.AUAX01000005_gene5154 2.8e-69 268.1 Micromonosporales groL GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 Bacteria 2GKC9@201174,4D901@85008,COG0459@1,COG0459@2 NA|NA|NA O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions KOPIJCMJ_02466 1078020.KEK_03787 6.7e-23 114.8 Mycobacteriaceae Bacteria 233RT@1762,2IAWJ@201174,COG2345@1,COG2345@2 NA|NA|NA K Transcriptional regulator KOPIJCMJ_02467 751945.Theos_1037 1.6e-170 605.9 Deinococcus-Thermus ko:K02575 ko00910,map00910 M00615 ko00000,ko00001,ko00002,ko02000 2.A.1.8 Bacteria 1WJJV@1297,COG2223@1,COG2223@2 NA|NA|NA P Major Facilitator Superfamily KOPIJCMJ_02468 1123386.AUIW01000006_gene1638 2.4e-147 528.9 Deinococcus-Thermus narK ko:K02575 ko00910,map00910 M00615 ko00000,ko00001,ko00002,ko02000 2.A.1.8 Bacteria 1WJ7D@1297,COG2223@1,COG2223@2 NA|NA|NA P Major Facilitator Superfamily KOPIJCMJ_02469 390989.JOEG01000004_gene3799 4e-82 312.0 Micromonosporales mog 2.10.1.1,2.8.1.12,4.6.1.17 ko:K03635,ko:K03637,ko:K03750 ko00790,ko01100,ko04122,map00790,map01100,map04122 R09395,R09735,R11372 RC02507,RC03425,RC03462 ko00000,ko00001,ko01000 Bacteria 2GP1B@201174,4DBSX@85008,COG0303@1,COG0303@2,COG0521@1,COG0521@2 NA|NA|NA H Probable molybdopterin binding domain KOPIJCMJ_02470 66373.JOFQ01000008_gene441 6.9e-42 177.9 Actinobacteria mobA 2.7.7.77 ko:K03752 ko00790,ko01100,map00790,map01100 R11581 ko00000,ko00001,ko01000 Bacteria 2GJVE@201174,COG0746@1,COG0746@2 NA|NA|NA H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor KOPIJCMJ_02471 1380393.JHVP01000002_gene1835 1.7e-44 185.7 Frankiales moaC 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 R11372 RC03425 ko00000,ko00001,ko01000 Bacteria 2IHR6@201174,4ESM0@85013,COG0315@1,COG0315@2 NA|NA|NA H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) KOPIJCMJ_02472 208444.JNYY01000006_gene6922 1e-67 263.8 Pseudonocardiales moaE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.7.7.80,2.8.1.11,2.8.1.12,4.6.1.17 ko:K03635,ko:K03637,ko:K21147 ko00790,ko01100,ko04122,map00790,map01100,map04122 R07459,R07461,R09395,R11372 RC00043,RC02507,RC03425 ko00000,ko00001,ko01000 Bacteria 2II28@201174,4DZNU@85010,COG0314@1,COG0314@2,COG0521@1,COG0521@2 NA|NA|NA H TIGRFAM molybdenum cofactor synthesis KOPIJCMJ_02473 1120936.KB907219_gene3177 2.8e-117 428.7 Streptosporangiales moaA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0030312,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0071944,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.22,4.6.1.17 ko:K03639,ko:K20967 ko00790,ko01100,ko04122,map00790,map01100,map04122 R09394,R11372 RC03420,RC03425 ko00000,ko00001,ko01000 Bacteria 2GN0V@201174,4EGC1@85012,COG2896@1,COG2896@2 NA|NA|NA H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate KOPIJCMJ_02474 1121952.ATXT01000015_gene350 3.3e-08 64.3 Microbacteriaceae moaD 2.8.1.12 ko:K03636,ko:K21142 ko00790,ko01100,ko04122,map00790,map01100,map04122 R09395 RC02507 ko00000,ko00001,ko01000 Bacteria 2HSWM@201174,4FQNM@85023,COG1977@1,COG1977@2 NA|NA|NA H ThiS family KOPIJCMJ_02475 570268.ANBB01000035_gene2253 2.3e-168 599.0 Streptosporangiales ptsI 2.7.3.9 ko:K08483 ko02060,map02060 ko00000,ko00001,ko01000,ko02000 8.A.7 Bacteria 2GIZZ@201174,4EGVU@85012,COG1080@1,COG1080@2 NA|NA|NA G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) KOPIJCMJ_02476 1292373.H640_07474 2.5e-16 91.3 Actinobacteria ptsH ko:K03488,ko:K11189 ko00000,ko02000,ko03000 4.A.2.1 Bacteria 2GQX6@201174,COG1925@1,COG1925@2 NA|NA|NA G phosphocarrier protein hpr KOPIJCMJ_02477 44060.JODL01000022_gene5029 2.9e-33 148.3 Actinobacteria crr 2.7.1.193,2.7.1.199 ko:K02777,ko:K02802,ko:K20116,ko:K20117,ko:K20118 ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111 M00265,M00266,M00267,M00268,M00270,M00272,M00303,M00806,M00809 R02738,R02780,R04111,R04394,R05132,R05199,R08559 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.1,4.A.1.1.13,4.A.1.1.14,4.A.1.1.2,4.A.1.1.9 Bacteria 2GK6B@201174,COG2190@1,COG2190@2 NA|NA|NA G Pts system KOPIJCMJ_02478 471852.Tcur_4029 6.1e-19 99.8 Streptosporangiales 2.7.1.193 ko:K02803 ko00520,ko02060,map00520,map02060 M00267 R05199 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7 Bacteria 2IQIB@201174,4EKNU@85012,COG1264@1,COG1264@2 NA|NA|NA G phosphotransferase system, EIIB KOPIJCMJ_02479 1449058.JQKT01000009_gene122 1.5e-75 290.0 Bacteria 5.5.1.24 ko:K09834 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00112 R07502,R07503,R10623,R10624 RC01911 ko00000,ko00001,ko00002,ko01000 Bacteria 2Z7HP@2,arCOG12964@1 NA|NA|NA S Tocopherol cyclase KOPIJCMJ_02480 351607.Acel_2022 1.9e-103 382.9 Frankiales pntAA 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 R00112 RC00001 ko00000,ko00001,ko01000 Bacteria 2I2FZ@201174,4ERQN@85013,COG3288@1,COG3288@2 NA|NA|NA C PFAM alanine dehydrogenase PNT domain protein KOPIJCMJ_02481 1120960.ATXG01000003_gene2102 3.4e-25 120.9 Microbacteriaceae pntAB 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 R00112 RC00001 ko00000,ko00001,ko01000 Bacteria 2IKR9@201174,4FPHA@85023,COG3288@1,COG3288@2 NA|NA|NA C 4TM region of pyridine nucleotide transhydrogenase, mitoch KOPIJCMJ_02482 479433.Caci_8567 3.7e-140 505.0 Actinobacteria pntB 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 R00112 RC00001 ko00000,ko00001,ko01000 Bacteria 2GNKB@201174,COG1282@1,COG1282@2 NA|NA|NA C the transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane KOPIJCMJ_02483 2045.KR76_24730 5e-51 207.2 Propionibacteriales tadA 3.5.4.1,3.5.4.33,3.8.1.5,6.3.4.19 ko:K01485,ko:K01563,ko:K04075,ko:K11991 ko00240,ko00330,ko00361,ko00625,ko01100,ko01120,map00240,map00330,map00361,map00625,map01100,map01120 R00974,R01411,R02922,R05284,R05367,R05368,R05369,R05370,R07669,R07670,R09597,R10223 RC00074,RC00477,RC00514,RC00809,RC01317,RC01340,RC01341,RC02013,RC02633,RC02634 ko00000,ko00001,ko01000,ko03016 Bacteria 2IM3Z@201174,4DQP2@85009,COG0590@1,COG0590@2 NA|NA|NA FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) KOPIJCMJ_02484 266940.Krad_0471 1.7e-71 275.8 Actinobacteria upp GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.9 ko:K00761 ko00240,ko01100,map00240,map01100 R00966 RC00063 ko00000,ko00001,ko01000 Bacteria 2GPJE@201174,COG0035@1,COG0035@2 NA|NA|NA F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate KOPIJCMJ_02485 1192034.CAP_7082 4e-43 182.2 Myxococcales ykfA 3.4.17.13 ko:K01297 ko00000,ko01000,ko01002,ko01011 Bacteria 1MWIY@1224,2WJ3S@28221,2YV3I@29,42Q52@68525,COG1619@1,COG1619@2 NA|NA|NA V LD-carboxypeptidase KOPIJCMJ_02487 1896.JOAU01000009_gene6381 7.3e-47 193.4 Actinobacteria osmC ko:K04063 ko00000 Bacteria 2IFFB@201174,COG1764@1,COG1764@2 NA|NA|NA O PFAM OsmC family protein KOPIJCMJ_02488 436229.JOEH01000017_gene6930 0.0 1198.7 Streptacidiphilus clpB GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 ko:K03694,ko:K03695 ko04213,map04213 ko00000,ko00001,ko03110 Bacteria 2GJ73@201174,2NGRH@228398,COG0542@1,COG0542@2 NA|NA|NA O C-terminal, D2-small domain, of ClpB protein KOPIJCMJ_02489 31964.CMS2809 6.6e-27 126.7 Microbacteriaceae hspR ko:K13640 ko00000,ko03000 Bacteria 2IQJ4@201174,4FP4F@85023,COG0789@1,COG0789@2 NA|NA|NA K helix_turn_helix, mercury resistance KOPIJCMJ_02490 1122611.KB903952_gene6087 6.6e-109 401.0 Streptosporangiales dnaJ GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0010468,GO:0016020,GO:0019222,GO:0030312,GO:0040007,GO:0043388,GO:0044093,GO:0044464,GO:0050789,GO:0051098,GO:0051099,GO:0051101,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:2000677,GO:2000679 ko:K03686,ko:K05516 ko00000,ko03029,ko03036,ko03110 Bacteria 2GJKK@201174,4EHSG@85012,COG0484@1,COG0484@2 NA|NA|NA O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins KOPIJCMJ_02491 351607.Acel_2116 9.4e-41 173.7 Frankiales grpE GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0007154,GO:0008150,GO:0009266,GO:0009267,GO:0009408,GO:0009605,GO:0009628,GO:0009986,GO:0009987,GO:0009991,GO:0016043,GO:0017076,GO:0019904,GO:0022607,GO:0030234,GO:0030246,GO:0030247,GO:0030312,GO:0030554,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0033554,GO:0036094,GO:0040007,GO:0042594,GO:0042802,GO:0042803,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0050790,GO:0050896,GO:0051082,GO:0051716,GO:0060589,GO:0060590,GO:0065003,GO:0065007,GO:0065009,GO:0071496,GO:0071840,GO:0071944,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065 ko:K02652,ko:K03687 ko00000,ko02035,ko02044,ko03029,ko03110 3.A.15.2 Bacteria 2GP4F@201174,4ESWP@85013,COG0576@1,COG0576@2 NA|NA|NA O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ KOPIJCMJ_02492 1123322.KB904702_gene229 1.3e-198 699.5 Actinobacteria dnaK ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 Bacteria 2GJTY@201174,COG0443@1,COG0443@2 NA|NA|NA O Heat shock 70 kDa protein KOPIJCMJ_02493 350054.Mflv_4283 2.2e-96 359.4 Mycobacteriaceae ko:K07497 ko00000 Bacteria 2371V@1762,2H9CR@201174,COG3328@1,COG3328@2 NA|NA|NA L Transposase, Mutator family KOPIJCMJ_02494 1033730.CAHG01000006_gene1163 5.4e-65 254.2 Propionibacteriales Bacteria 2GMV5@201174,4DQDH@85009,COG1432@1,COG1432@2 NA|NA|NA S NYN domain KOPIJCMJ_02495 479435.Kfla_3543 2.4e-59 236.1 Actinobacteria ko:K04763 ko00000,ko03036 Bacteria 2GNXS@201174,COG4974@1,COG4974@2 NA|NA|NA L Belongs to the 'phage' integrase family KOPIJCMJ_02496 1122239.AULS01000014_gene2302 7e-12 76.6 Microbacteriaceae higA ko:K18831,ko:K21498 ko00000,ko02048,ko03000 Bacteria 2GNHW@201174,4FPAD@85023,COG3093@1,COG3093@2 NA|NA|NA K Pfam:DUF955 KOPIJCMJ_02497 1449353.JQMQ01000005_gene1989 2.7e-85 322.0 Streptacidiphilus potA 3.6.3.31 ko:K11072 ko02010,map02010 M00299 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.11.1 Bacteria 2GJCM@201174,2NG9M@228398,COG3842@1,COG3842@2 NA|NA|NA E TOBE domain KOPIJCMJ_02498 1504319.GM45_4535 6.2e-99 367.5 unclassified Actinobacteria (class) potH ko:K11071 ko02010,map02010 M00299 ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 Bacteria 2GJ5G@201174,3UWG9@52018,COG1176@1,COG1176@2 NA|NA|NA P COG1176 ABC-type spermidine putrescine transport system, permease component I KOPIJCMJ_02499 1504319.GM45_4540 3e-95 355.1 unclassified Actinobacteria (class) potC ko:K11070 ko02010,map02010 M00299 ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 Bacteria 2GJ6Q@201174,3UWPB@52018,COG1177@1,COG1177@2 NA|NA|NA P COG1177 ABC-type spermidine putrescine transport system, permease component II KOPIJCMJ_02500 670487.Ocepr_1979 3.1e-17 95.9 Deinococcus-Thermus rlmN GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 ko:K06941 ko00000,ko01000,ko03009 Bacteria 1WICE@1297,COG0820@1,COG0820@2 NA|NA|NA J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs KOPIJCMJ_02501 570268.ANBB01000037_gene2671 5e-57 229.2 Streptosporangiales Bacteria 2GIV0@201174,4EM8V@85012,COG0515@1,COG0515@2 NA|NA|NA KLT SMART serine threonine protein kinase KOPIJCMJ_02502 1157637.KB892115_gene4645 1.1e-158 566.6 Actinobacteria Bacteria 2GJQ9@201174,COG0665@1,COG0665@2 NA|NA|NA E FAD dependent oxidoreductase KOPIJCMJ_02504 471852.Tcur_4438 8.1e-163 580.5 Streptosporangiales hemD GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 ko:K02302,ko:K02303,ko:K13542 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03165,R03194,R03947 RC00003,RC00871,RC01012,RC01034,RC01861 ko00000,ko00001,ko00002,ko01000 Bacteria 2GMJZ@201174,4EFW8@85012,COG0007@1,COG0007@2,COG1587@1,COG1587@2 NA|NA|NA H Uroporphyrinogen-III synthase HemD KOPIJCMJ_02505 996637.SGM_1352 3.2e-74 285.4 Actinobacteria hemC GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 Bacteria 2GMWI@201174,COG0181@1,COG0181@2 NA|NA|NA H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps KOPIJCMJ_02506 1211815.CBYP010000047_gene1633 1.1e-96 360.5 Frankiales hemA GO:0005575,GO:0005623,GO:0008150,GO:0009288,GO:0040007,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040 1.2.1.70 ko:K02407,ko:K02492 ko00860,ko01100,ko01110,ko01120,ko02040,map00860,map01100,map01110,map01120,map02040 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000,ko02035 iSB619.SA_RS08420 Bacteria 2GJRA@201174,4ERHS@85013,COG0373@1,COG0373@2 NA|NA|NA H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) KOPIJCMJ_02507 1894.JOER01000011_gene2071 4.1e-81 307.8 Actinobacteria Bacteria 2GK4B@201174,COG2197@1,COG2197@2 NA|NA|NA T response regulator KOPIJCMJ_02508 1380390.JIAT01000017_gene5376 2.5e-64 252.7 Rubrobacteria iolTA ko:K02058,ko:K10439 ko02010,ko02030,map02010,map02030 M00212,M00221 ko00000,ko00001,ko00002,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 Bacteria 2GKIJ@201174,4CQ39@84995,COG1879@1,COG1879@2 NA|NA|NA G Periplasmic binding protein domain KOPIJCMJ_02509 1122939.ATUD01000006_gene1730 6e-90 337.8 Rubrobacteria iolTB ko:K02057,ko:K03466 M00221 ko00000,ko00002,ko02000,ko03036 3.A.1.2,3.A.12 Bacteria 2GM9E@201174,4CPYC@84995,COG1172@1,COG1172@2 NA|NA|NA G Branched-chain amino acid transport system / permease component KOPIJCMJ_02510 67257.JODR01000002_gene1060 3.6e-95 354.8 Actinobacteria 3.6.3.17 ko:K02056 M00221 ko00000,ko00002,ko01000,ko02000 3.A.1.2 Bacteria 2GJDV@201174,COG1129@1,COG1129@2 NA|NA|NA G ABC transporter KOPIJCMJ_02511 591159.ACEZ01000134_gene2353 1.2e-145 523.5 Actinobacteria cydC ko:K06148,ko:K16012,ko:K16013,ko:K16014 ko02010,map02010 ko00000,ko00001,ko02000 3.A.1,3.A.1.129 Bacteria 2I2DP@201174,COG4987@1,COG4987@2,COG4988@1,COG4988@2 NA|NA|NA V ABC transporter CydDC cysteine exporter (CydDC-E) family permease ATP-binding protein CydD KOPIJCMJ_02512 1134445.AJJM01000001_gene2720 4.9e-129 468.4 Actinobacteria cydC ko:K06148,ko:K16012,ko:K16013,ko:K16014 ko02010,map02010 ko00000,ko00001,ko02000 3.A.1,3.A.1.129 Bacteria 2I2DP@201174,COG4987@1,COG4987@2,COG4988@1,COG4988@2 NA|NA|NA V ABC transporter CydDC cysteine exporter (CydDC-E) family permease ATP-binding protein CydD KOPIJCMJ_02513 1123320.KB889730_gene6071 1.2e-121 443.7 Actinobacteria Bacteria 2GIWI@201174,COG3850@1,COG3850@2 NA|NA|NA T Histidine kinase KOPIJCMJ_02514 35754.JNYJ01000014_gene4724 2.1e-119 435.6 Micromonosporales cydB GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0016682,GO:0019646,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0070069,GO:0071944,GO:0097159,GO:1901363 1.10.3.14 ko:K00426 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 iECABU_c1320.ECABU_c10120,iLF82_1304.LF82_0101,iNRG857_1313.NRG857_04455,iPC815.YPO1118,ic_1306.c1120 Bacteria 2GMFV@201174,4DATV@85008,COG1294@1,COG1294@2 NA|NA|NA C cytochrome d ubiquinol oxidase, subunit KOPIJCMJ_02515 469371.Tbis_2750 3.9e-169 601.3 Pseudonocardiales cydA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0016682,GO:0019646,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0070069,GO:0071944,GO:0097159,GO:1901363 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 iPC815.YPO1117,iSBO_1134.SBO_2253,iSFxv_1172.SFxv_0621,iS_1188.S0577,iSbBS512_1146.SbBS512_E2337 Bacteria 2GJE4@201174,4DZRD@85010,COG1271@1,COG1271@2 NA|NA|NA C Cytochrome bd-type quinol oxidase, subunit 1 KOPIJCMJ_02516 1035308.AQYY01000001_gene3303 2.7e-45 188.7 Clostridia 1.1.1.65 ko:K05275 ko00750,ko01100,ko01120,map00750,map01100,map01120 R01708 RC00116 ko00000,ko00001,ko01000 Bacteria 1TPIY@1239,25B3Z@186801,COG0667@1,COG0667@2 NA|NA|NA C aldo keto reductase KOPIJCMJ_02517 1184609.KILIM_003_01140 1e-37 162.5 Actinobacteria Bacteria 2IRSY@201174,COG3657@1,COG3657@2 NA|NA|NA S addiction module killer protein KOPIJCMJ_02519 593907.Celgi_0953 7.7e-24 116.7 Cellulomonadaceae ko:K07979 ko00000,ko03000 Bacteria 2IQEW@201174,4F2NR@85016,COG1725@1,COG1725@2 NA|NA|NA K Helix-turn-helix domain KOPIJCMJ_02520 743718.Isova_2573 5.6e-25 121.7 Promicromonosporaceae Bacteria 2ERYQ@1,2GXQP@201174,33JHV@2,4F4YJ@85017 NA|NA|NA KOPIJCMJ_02522 1172188.KB911822_gene923 2.4e-27 127.9 Intrasporangiaceae Bacteria 2ISFT@201174,4FHVU@85021,COG2315@1,COG2315@2 NA|NA|NA S YjbR KOPIJCMJ_02527 1123320.KB889596_gene8626 1.5e-17 96.3 Actinobacteria ko:K03088 ko00000,ko03021 Bacteria 2IKVM@201174,COG1595@1,COG1595@2 NA|NA|NA K belongs to the sigma-70 factor family, ECF subfamily KOPIJCMJ_02528 1121019.AUMN01000004_gene1337 1.2e-07 63.5 Micrococcaceae Bacteria 1WAGS@1268,2DRTH@1,2GY6H@201174,33CZB@2 NA|NA|NA KOPIJCMJ_02529 1449976.KALB_8405 1.3e-40 172.9 Pseudonocardiales Bacteria 2GNA1@201174,4DXC5@85010,COG1695@1,COG1695@2 NA|NA|NA K Transcriptional regulator KOPIJCMJ_02530 1394178.AWOO02000006_gene3480 5.7e-14 85.5 Streptosporangiales Bacteria 2HY5T@201174,4EPNA@85012,COG3266@1,COG3266@2 NA|NA|NA S domain, Protein KOPIJCMJ_02532 1463934.JOCF01000098_gene4313 1.7e-16 92.0 Actinobacteria Bacteria 28U93@1,2GXR6@201174,2ZGEN@2 NA|NA|NA KOPIJCMJ_02534 1429046.RR21198_1046 1.8e-07 63.5 Actinobacteria Bacteria 2GYB1@201174,COG1396@1,COG1396@2 NA|NA|NA K Helix-turn-helix XRE-family like proteins KOPIJCMJ_02535 1048339.KB913029_gene158 3.6e-39 169.1 Frankiales Bacteria 2IHBR@201174,4EW9H@85013,COG0741@1,COG0741@2,COG3103@1,COG4991@2 NA|NA|NA MT Transglycosylase SLT domain KOPIJCMJ_02537 356851.JOAN01000015_gene2410 1.6e-113 416.4 Micromonosporales ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GIRW@201174,4D8P2@85008,COG0577@1,COG0577@2 NA|NA|NA V COG0577 ABC-type antimicrobial peptide transport system, permease component KOPIJCMJ_02538 1214101.BN159_2089 2.7e-70 271.9 Actinobacteria ko:K02003 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GK3I@201174,COG1136@1,COG1136@2 NA|NA|NA V ABC transporter KOPIJCMJ_02539 1121926.AXWO01000009_gene2795 6.4e-40 171.0 Actinobacteria Bacteria 2I9HW@201174,COG3409@1,COG3409@2 NA|NA|NA M Putative peptidoglycan binding domain KOPIJCMJ_02540 570268.ANBB01000085_gene3174 4.1e-35 154.5 Streptosporangiales alx ko:K05794 ko00000 Bacteria 2GIWU@201174,4EGZN@85012,COG0861@1,COG0861@2 NA|NA|NA P Integral membrane protein TerC family KOPIJCMJ_02541 1120705.FG95_02957 7.2e-27 127.9 Proteobacteria Bacteria 1P5TP@1224,2DDXM@1,2ZJQE@2 NA|NA|NA S Psort location Cytoplasmic, score 8.96 KOPIJCMJ_02542 196164.23493346 3.6e-07 61.6 Bacteria Bacteria 2E4RD@1,33NSC@2 NA|NA|NA KOPIJCMJ_02543 546267.NEIPOLOT_02541 2.6e-45 189.5 Betaproteobacteria Bacteria 1NJPV@1224,2E4RD@1,2W2WZ@28216,32ZJX@2 NA|NA|NA S Psort location Cytoplasmic, score 8.96 KOPIJCMJ_02544 1210045.ALNP01000036_gene2343 5.6e-08 63.5 Actinobacteria thyX 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 R06613 RC00022,RC00332 ko00000,ko00001,ko01000 Bacteria 2HCNJ@201174,COG1351@1,COG1351@2 NA|NA|NA F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant KOPIJCMJ_02545 1193181.BN10_1320023 7.5e-57 227.3 Actinobacteria 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 R00578 RC00010 ko00000,ko00001,ko01000,ko01002 Bacteria 2IAKK@201174,COG1478@1,COG1478@2 NA|NA|NA S F420-0:Gamma-glutamyl ligase KOPIJCMJ_02546 68570.DC74_5827 1.2e-107 396.4 Actinobacteria dapA 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ34@201174,COG0329@1,COG0329@2 NA|NA|NA E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) KOPIJCMJ_02547 2002.JOEQ01000043_gene5973 1.3e-41 176.8 Streptosporangiales MA20_36340 Bacteria 2GN6D@201174,4EFJ2@85012,COG0494@1,COG0494@2 NA|NA|NA L NUDIX hydrolase KOPIJCMJ_02548 1184607.AUCHE_04_00900 3.3e-48 198.0 Dermatophilaceae Bacteria 2IHNE@201174,4F6ZV@85018,COG0251@1,COG0251@2 NA|NA|NA J Endoribonuclease L-PSP KOPIJCMJ_02549 1169154.KB897777_gene3606 3e-17 93.6 Actinobacteria Bacteria 2E3JZ@1,2GQIX@201174,32YI8@2 NA|NA|NA KOPIJCMJ_02550 105420.BBPO01000071_gene4051 3.4e-78 298.1 Streptacidiphilus glxR GO:0000166,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010675,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030312,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0032993,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000874,GO:2001141 ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 ko00000,ko00001,ko03000 Bacteria 2GMPN@201174,2NFJS@228398,COG0664@1,COG0664@2 NA|NA|NA T helix_turn_helix, cAMP Regulatory protein KOPIJCMJ_02551 351607.Acel_1994 2.2e-26 125.6 Frankiales Bacteria 2AZUF@1,2HU1W@201174,31S3S@2,4EWGK@85013 NA|NA|NA KOPIJCMJ_02552 1120950.KB892762_gene5486 4.2e-90 337.8 Propionibacteriales nth GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0030312,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 4.2.99.18 ko:K10773 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 2GJ01@201174,4DNJN@85009,COG0177@1,COG0177@2 NA|NA|NA L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate KOPIJCMJ_02553 1120950.KB892762_gene5484 3.3e-62 245.0 Propionibacteriales Bacteria 2GKG9@201174,4DQJF@85009,COG0494@1,COG0494@2 NA|NA|NA L NUDIX domain KOPIJCMJ_02554 1122182.KB903835_gene4527 5.4e-47 195.3 Micromonosporales cvpA GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009268,GO:0009405,GO:0009628,GO:0010447,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051704,GO:0071944 Bacteria 2GJ92@201174,4DA7U@85008,COG0265@1,COG0265@2 NA|NA|NA O Peptidase s1 and s6 chymotrypsin hap KOPIJCMJ_02555 1123320.KB889692_gene167 1.5e-100 372.9 Actinobacteria Bacteria 2I2IM@201174,COG2267@1,COG2267@2 NA|NA|NA I Alpha beta hydrolase KOPIJCMJ_02556 1380356.JNIK01000011_gene1918 4e-13 81.6 Frankiales Bacteria 2DPPE@1,2IN30@201174,332VJ@2,4ETAT@85013 NA|NA|NA S Putative Actinobacterial Holin-X, holin superfamily III KOPIJCMJ_02557 1123320.KB889692_gene169 1.3e-105 390.2 Actinobacteria nhaA ko:K03313 ko00000,ko02000 2.A.33.1 Bacteria 2GKIK@201174,COG3004@1,COG3004@2 NA|NA|NA P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons KOPIJCMJ_02559 1095767.CAHD01000130_gene1332 8e-80 303.9 Cellulomonadaceae truA GO:0000049,GO:0001522,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 5.4.99.12 ko:K06173 ko00000,ko01000,ko03016 Bacteria 2GJ6C@201174,4F0W6@85016,COG0101@1,COG0101@2 NA|NA|NA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs KOPIJCMJ_02560 471853.Bcav_3112 4.2e-53 214.5 Actinobacteria rplQ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 ko:K02879 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IHV2@201174,COG0203@1,COG0203@2 NA|NA|NA J ribosomal protein L17 KOPIJCMJ_02561 471852.Tcur_4290 5.8e-151 540.4 Streptosporangiales rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 Bacteria 2GJJ5@201174,4EGUV@85012,COG0202@1,COG0202@2 NA|NA|NA K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates KOPIJCMJ_02562 1123320.KB889574_gene5545 1.5e-96 359.0 Actinobacteria rpsD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0016020,GO:0019222,GO:0019843,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 ko:K02986 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GIRX@201174,COG0522@1,COG0522@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit KOPIJCMJ_02563 1306174.JODP01000006_gene3594 3.9e-61 240.7 Actinobacteria rpsK GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02948 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IFFC@201174,COG0100@1,COG0100@2 NA|NA|NA J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome KOPIJCMJ_02564 469371.Tbis_0590 1.1e-52 212.6 Pseudonocardiales rpsM GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02952 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IHPN@201174,4E3FF@85010,COG0099@1,COG0099@2 NA|NA|NA J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits KOPIJCMJ_02565 1284679.HMPREF1626_05675 1.4e-13 80.9 Actinobacteria rpmJ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02919 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GWMH@201174,4D6P0@85005,COG0257@1,COG0257@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL36 family KOPIJCMJ_02566 269800.Tfu_2622 1.2e-32 145.2 Streptosporangiales infA GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009986,GO:0016020,GO:0030246,GO:0030247,GO:0030312,GO:0040007,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071944,GO:2001065 ko:K02518 ko00000,ko03012 Bacteria 2IQ4B@201174,4EK2Q@85012,COG0361@1,COG0361@2 NA|NA|NA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex KOPIJCMJ_02567 530564.Psta_3683 4.4e-135 488.0 Planctomycetes Bacteria 2IX7A@203682,COG0464@1,COG0464@2 NA|NA|NA O growth KOPIJCMJ_02568 530564.Psta_3683 8.3e-134 483.8 Planctomycetes Bacteria 2IX7A@203682,COG0464@1,COG0464@2 NA|NA|NA O growth KOPIJCMJ_02569 1120950.KB892746_gene3632 3.7e-79 301.6 Propionibacteriales map GO:0000096,GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006464,GO:0006508,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009066,GO:0009987,GO:0010467,GO:0016020,GO:0016151,GO:0016485,GO:0016787,GO:0019538,GO:0019752,GO:0030145,GO:0035551,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044464,GO:0046872,GO:0046914,GO:0050897,GO:0051604,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901605 3.4.11.18 ko:K01265 ko00000,ko01000,ko01002 Bacteria 2GKKB@201174,4DNQ9@85009,COG0024@1,COG0024@2 NA|NA|NA J Methionine aminopeptidase KOPIJCMJ_02570 1120941.AUBL01000002_gene2052 1.3e-59 236.1 Actinobacteria adk 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GJ7T@201174,4D4SK@85005,COG0563@1,COG0563@2 NA|NA|NA F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism KOPIJCMJ_02571 1504319.GM45_2550 3.4e-159 568.2 unclassified Actinobacteria (class) secY GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5 Bacteria 2GJ26@201174,3UWEW@52018,COG0201@1,COG0201@2 NA|NA|NA U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently KOPIJCMJ_02572 1095767.CAHD01000130_gene1318 1.2e-52 212.6 Cellulomonadaceae rplO GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02876 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2II6M@201174,4F16W@85016,COG0200@1,COG0200@2 NA|NA|NA J Binds to the 23S rRNA KOPIJCMJ_02573 1121933.AUHH01000003_gene1376 1.2e-14 85.1 Propionibacteriales rpmD GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02907 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GQV0@201174,4DSCE@85009,COG1841@1,COG1841@2 NA|NA|NA J Ribosomal protein L30 KOPIJCMJ_02574 1169154.KB897780_gene2355 1.1e-61 242.7 Actinobacteria rpsE GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990145,GO:1990904 ko:K02988 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GJW8@201174,COG0098@1,COG0098@2 NA|NA|NA J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body KOPIJCMJ_02575 67352.JODS01000014_gene5359 2.7e-150 538.1 Actinobacteria uvrA GO:0000018,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045910,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0071944,GO:0080090 ko:K03701 ko03420,map03420 ko00000,ko00001,ko03400 Bacteria 2GJUV@201174,COG0178@1,COG0178@2 NA|NA|NA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate KOPIJCMJ_02576 369723.Strop_1655 3.2e-14 85.5 Micromonosporales Bacteria 2I2JE@201174,4DMR8@85008,COG0723@1,COG0723@2 NA|NA|NA C Rieske [2Fe-2S] domain KOPIJCMJ_02577 105422.BBPM01000004_gene5337 4.1e-225 787.7 Streptacidiphilus uvrC GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016787,GO:0016788,GO:0030312,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1902494,GO:1905347,GO:1905348,GO:1990391 ko:K03703 ko03420,map03420 ko00000,ko00001,ko03400 Bacteria 2GIS4@201174,2NEJF@228398,COG0322@1,COG0322@2 NA|NA|NA L GIY-YIG type nucleases (URI domain) KOPIJCMJ_02578 100226.SCO1952 5.2e-95 354.4 Actinobacteria rapZ GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363 ko:K06958 ko00000,ko03019 Bacteria 2GMWB@201174,COG1660@1,COG1660@2 NA|NA|NA S Displays ATPase and GTPase activities KOPIJCMJ_02579 1380346.JNIH01000005_gene3152 6.8e-91 340.9 Actinobacteria ybhK Bacteria 2GJBW@201174,COG0391@1,COG0391@2 NA|NA|NA S Required for morphogenesis under gluconeogenic growth conditions KOPIJCMJ_02580 1123322.KB904653_gene803 2.2e-139 501.9 Actinobacteria whiA GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0043937,GO:0044464,GO:0050789,GO:0050793,GO:0065007,GO:0071944 ko:K09762 ko00000 Bacteria 2GJZU@201174,COG1481@1,COG1481@2 NA|NA|NA K May be required for sporulation KOPIJCMJ_02581 446471.Xcel_1549 2.9e-136 491.9 Promicromonosporaceae pgk GO:0003674,GO:0003824,GO:0004618,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.2.3,5.3.1.1 ko:K00927,ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01015,R01512 RC00002,RC00043,RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GJC6@201174,4F49B@85017,COG0126@1,COG0126@2 NA|NA|NA G Phosphoglycerate kinase KOPIJCMJ_02582 500153.JOEK01000014_gene5647 9.2e-104 383.3 Actinobacteria tpiA GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 2.7.2.3,5.3.1.1 ko:K00927,ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01015,R01512 RC00002,RC00043,RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GJXZ@201174,COG0149@1,COG0149@2 NA|NA|NA G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) KOPIJCMJ_02583 1298863.AUEP01000005_gene2451 9.3e-17 92.4 Propionibacteriales secG GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 Bacteria 2GR31@201174,4DS3V@85009,COG1314@1,COG1314@2 NA|NA|NA U Preprotein translocase SecG subunit KOPIJCMJ_02584 100226.SCO1943 1.1e-42 179.1 Actinobacteria rbpA Bacteria 2CNY9@1,2IKKZ@201174,31GEE@2 NA|NA|NA K Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters KOPIJCMJ_02585 452652.KSE_55490 7.6e-254 883.2 Kitasatospora tkt 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ1K@201174,2M2DG@2063,COG0021@1,COG0021@2 NA|NA|NA G Transketolase, thiamine diphosphate binding domain KOPIJCMJ_02586 710696.Intca_1695 4.7e-88 331.3 Intrasporangiaceae ctaB GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 Bacteria 2GJMY@201174,4FEY1@85021,COG0109@1,COG0109@2 NA|NA|NA O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group KOPIJCMJ_02587 219305.MCAG_00019 5.9e-74 285.0 Micromonosporales 2.7.13.3 ko:K02484,ko:K07653 ko02020,map02020 M00460 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 2I3U8@201174,4D9HY@85008,COG5002@1,COG5002@2 NA|NA|NA T His Kinase A (phosphoacceptor) domain KOPIJCMJ_02588 512565.AMIS_40330 5.6e-81 307.4 Micromonosporales Bacteria 2GMVN@201174,4D8W6@85008,COG0745@1,COG0745@2 NA|NA|NA T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain KOPIJCMJ_02590 1121385.AQXW01000004_gene1221 1.1e-66 260.4 Dermacoccaceae ctaA ko:K02259 ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714 M00154 R07412 RC00769 ko00000,ko00001,ko00002,ko03029 3.D.4.4 Bacteria 1ZVU4@145357,2GJQX@201174,COG1612@1,COG1612@2 NA|NA|NA O Cytochrome oxidase assembly protein KOPIJCMJ_02591 1394178.AWOO02000020_gene7495 2.9e-49 202.2 Streptosporangiales ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GN6S@201174,4EI28@85012,COG0842@1,COG0842@2 NA|NA|NA V ABC-2 family transporter protein KOPIJCMJ_02592 1137269.AZWL01000008_gene4672 1.1e-92 346.7 Actinobacteria drrA_2 ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GJBF@201174,COG1131@1,COG1131@2 NA|NA|NA V ABC transporter KOPIJCMJ_02593 479435.Kfla_3277 1.4e-58 233.0 Propionibacteriales sufR Bacteria 2GN8W@201174,4DQCB@85009,COG2345@1,COG2345@2 NA|NA|NA K Transcriptional regulator KOPIJCMJ_02595 1101188.KI912157_gene288 4.3e-15 87.4 Actinobacteria Bacteria 2BH0A@1,2GUIE@201174,32B0E@2 NA|NA|NA KOPIJCMJ_02597 861360.AARI_pI00280 5e-14 85.5 Actinobacteria Bacteria 2D2AG@1,2IARE@201174,32TCD@2 NA|NA|NA KOPIJCMJ_02598 67281.JNZZ01000009_gene810 5e-69 268.9 Streptomyces griseus group Bacteria 28IPW@1,2HQJM@201174,2Z8PQ@2,41CVI@629295 NA|NA|NA KOPIJCMJ_02599 1449353.JQMQ01000005_gene5752 1.4e-121 443.4 Actinobacteria Bacteria 2I37H@201174,COG3451@1,COG3451@2 NA|NA|NA U type IV secretory pathway VirB4 KOPIJCMJ_02600 1464048.JNZS01000015_gene3724 5.2e-118 431.8 Micromonosporales Bacteria 2GNQ7@201174,4D94E@85008,COG3505@1,COG3505@2 NA|NA|NA U Type IV secretory pathway, VirD4 components KOPIJCMJ_02601 591158.SSMG_08390 2e-08 66.2 Actinobacteria Bacteria 2E3KC@1,2GQQS@201174,32YIM@2 NA|NA|NA S Domain of unknown function (DUF4913) KOPIJCMJ_02603 1038860.AXAP01000018_gene3103 1.8e-40 172.2 Bradyrhizobiaceae Bacteria 1RGXV@1224,2U9EH@28211,3JY58@41294,COG5579@1,COG5579@2 NA|NA|NA S Protein of unknown function (DUF1810) KOPIJCMJ_02604 1122130.AUHN01000005_gene2450 2.7e-23 116.3 Bacteria 3.2.1.14 ko:K01183 ko00520,ko01100,map00520,map01100 R01206,R02334 RC00467 ko00000,ko00001,ko01000 GH18 Bacteria COG2374@1,COG2374@2,COG4733@1,COG4733@2 NA|NA|NA S cellulase activity KOPIJCMJ_02605 1200352.A606_06160 1.8e-79 302.0 Corynebacteriaceae pdxS GO:0003674,GO:0005488,GO:0005515,GO:0042802 4.3.3.6 ko:K06215 ko00750,map00750 R07456 RC00010,RC01783,RC03043 ko00000,ko00001,ko01000 Bacteria 22K6Q@1653,2GK1T@201174,COG0214@1,COG0214@2 NA|NA|NA H Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively KOPIJCMJ_02606 1463887.KL589984_gene3407 5.7e-69 267.3 Actinobacteria pdxT GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0071496,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600 4.3.3.6 ko:K08681 ko00750,map00750 R07456 RC00010,RC01783,RC03043 ko00000,ko00001,ko01000 iHN637.CLJU_RS19495 Bacteria 2GNYG@201174,COG0311@1,COG0311@2 NA|NA|NA H Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS KOPIJCMJ_02607 269800.Tfu_2096 3.7e-110 404.4 Streptosporangiales yebC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 Bacteria 2GJ4G@201174,4EGE0@85012,COG0217@1,COG0217@2 NA|NA|NA K Transcriptional regulator KOPIJCMJ_02609 227882.SAV_5 2.1e-19 103.2 Actinobacteria Bacteria 2ARC3@1,2IAHR@201174,31GN3@2 NA|NA|NA KOPIJCMJ_02610 644548.SCNU_00065 1.8e-39 170.2 Gordoniaceae Bacteria 2GMMI@201174,4GD92@85026,COG0582@1,COG0582@2 NA|NA|NA L Belongs to the 'phage' integrase family KOPIJCMJ_02611 1348663.KCH_66760 2.1e-77 296.6 Kitasatospora accD GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009059,GO:0009273,GO:0009987,GO:0016020,GO:0016053,GO:0019752,GO:0032787,GO:0034645,GO:0042546,GO:0043170,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070589,GO:0071554,GO:0071704,GO:0071766,GO:0071767,GO:0071768,GO:0071840,GO:0071944,GO:0072330,GO:1901576 2.1.3.15,6.4.1.2 ko:K01962,ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 Bacteria 2GNP7@201174,2M0IK@2063,COG0777@1,COG0777@2,COG0825@1,COG0825@2 NA|NA|NA I Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit KOPIJCMJ_02613 465515.Mlut_00450 8.2e-86 324.3 Micrococcaceae GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 ko:K07485 ko00000 Bacteria 1WAN7@1268,2GJK7@201174,COG3464@1,COG3464@2 NA|NA|NA L PFAM Transposase KOPIJCMJ_02616 1194972.MVAC_16585 2.1e-16 92.8 Mycobacteriaceae 3.4.25.1 ko:K03433 ko03050,map03050 M00342,M00343 ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 Bacteria 234TK@1762,2HIHG@201174,COG0638@1,COG0638@2 NA|NA|NA O 20S proteasome KOPIJCMJ_02618 1120948.KB903217_gene1344 1.4e-19 103.6 Actinobacteria Bacteria 2IPMP@201174,COG3064@1,COG3064@2,COG4733@1,COG4733@2 NA|NA|NA M calcium- and calmodulin-responsive adenylate cyclase activity KOPIJCMJ_02619 1283283.ATXA01000008_gene3123 2.8e-45 188.7 Frankiales Bacteria 2CA7I@1,2IFD8@201174,2ZTHS@2,4EV1F@85013 NA|NA|NA KOPIJCMJ_02620 1380370.JIBA01000012_gene3816 6e-67 261.2 Intrasporangiaceae ko:K04088,ko:K14393 M00742 ko00000,ko00002,ko01000,ko02000 2.A.21.7 Bacteria 2IE4A@201174,4FIM4@85021,COG0330@1,COG0330@2 NA|NA|NA O SPFH domain / Band 7 family KOPIJCMJ_02621 2002.JOEQ01000025_gene232 8e-07 60.1 Streptosporangiales ko:K06975 ko00000 Bacteria 2GQNP@201174,4EKDK@85012,COG2388@1,COG2388@2 NA|NA|NA S GCN5-related N-acetyl-transferase KOPIJCMJ_02623 1386089.N865_21145 9.9e-68 263.8 Actinobacteria GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016874,GO:0016879,GO:0016881,GO:0018169,GO:0018410,GO:0019538,GO:0031668,GO:0033554,GO:0036211,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0070739,GO:0071496,GO:0071704,GO:0140096,GO:1901564 ko:K03281,ko:K03455,ko:K03499,ko:K05571,ko:K05844,ko:K07402,ko:K11105 ko00000,ko01000,ko02000,ko03009 2.A.36.6,2.A.37,2.A.38.1,2.A.38.4,2.A.49,2.A.63.1,2.A.63.2 Bacteria 2I2I2@201174,COG0569@1,COG0569@2 NA|NA|NA P Ion transport protein KOPIJCMJ_02624 1380390.JIAT01000011_gene2324 3.2e-22 112.8 Rubrobacteria Bacteria 2GK0H@201174,4CTG0@84995,COG0628@1,COG0628@2 NA|NA|NA S AI-2E family transporter KOPIJCMJ_02625 1298863.AUEP01000012_gene3662 2.7e-36 158.7 Propionibacteriales ko:K21429 ko00000,ko01002 Bacteria 2GKWI@201174,4DUPV@85009,COG4894@1,COG4894@2 NA|NA|NA S LURP-one-related KOPIJCMJ_02626 1386089.N865_21420 2.2e-29 135.2 Intrasporangiaceae Bacteria 2AY0M@1,2I859@201174,32Z2S@2,4FH02@85021 NA|NA|NA S Phospholipase_D-nuclease N-terminal KOPIJCMJ_02627 1229780.BN381_800004 1.5e-06 60.5 Actinobacteria ko:K11748 ko00000,ko02000 2.A.37.1.2 Bacteria 2DDQ5@1,2HDNV@201174,2ZIVU@2 NA|NA|NA KOPIJCMJ_02628 1122182.KB903814_gene3437 1.3e-29 137.1 Micromonosporales kipA Bacteria 2GITH@201174,4DBQR@85008,COG1984@1,COG1984@2 NA|NA|NA E Allophanate hydrolase subunit 2 KOPIJCMJ_02629 1151126.AQYI01000006_gene2850 2.8e-34 152.1 Microbacteriaceae ybgK Bacteria 2GITH@201174,4FMAJ@85023,COG1984@1,COG1984@2,COG2049@1,COG2049@2 NA|NA|NA E Allophanate hydrolase subunit 2 KOPIJCMJ_02630 44060.JODL01000024_gene339 1.1e-40 173.7 Actinobacteria lamB ko:K07160 ko00000 Bacteria 2GJA1@201174,COG1540@1,COG1540@2 NA|NA|NA S Belongs to the UPF0271 (lamB) family KOPIJCMJ_02631 216594.MMAR_1906 6.7e-19 99.8 Mycobacteriaceae Bacteria 23AN3@1762,2IQKN@201174,COG5552@1,COG5552@2 NA|NA|NA S Uncharacterized conserved protein (DUF2277) KOPIJCMJ_02632 1123251.ATWM01000003_gene1274 9.4e-91 341.7 Intrasporangiaceae 2.7.8.12 ko:K09809 ko00000,ko01000 Bacteria 2GM0T@201174,4FISM@85021,COG1887@1,COG1887@2 NA|NA|NA M CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase KOPIJCMJ_02634 479433.Caci_1405 9.8e-38 162.5 Actinobacteria prfB GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02836 ko00000,ko03012 Bacteria 2GJ0F@201174,COG1186@1,COG1186@2 NA|NA|NA J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA KOPIJCMJ_02635 1123320.KB889677_gene2736 6.1e-99 367.1 Actinobacteria ftsE GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019897,GO:0019898,GO:0030145,GO:0030554,GO:0031234,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363 ko:K09811,ko:K09812 ko02010,map02010 M00256 ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 Bacteria 2GJE1@201174,COG2884@1,COG2884@2 NA|NA|NA D cell division ATP-binding protein FtsE KOPIJCMJ_02636 1048339.KB913029_gene5048 5.2e-82 311.2 Frankiales ftsX GO:0000910,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0007154,GO:0007165,GO:0007166,GO:0008150,GO:0008356,GO:0009274,GO:0009276,GO:0009966,GO:0009987,GO:0010033,GO:0010646,GO:0016020,GO:0016021,GO:0016043,GO:0019221,GO:0022402,GO:0022603,GO:0022607,GO:0023051,GO:0023052,GO:0030312,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0032153,GO:0032506,GO:0034097,GO:0040007,GO:0042173,GO:0042221,GO:0043937,GO:0043938,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051301,GO:0051716,GO:0065007,GO:0070098,GO:0070297,GO:0070887,GO:0071310,GO:0071345,GO:0071840,GO:0071944,GO:0090529,GO:1902531 ko:K09811,ko:K09812 ko02010,map02010 M00256 ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 Bacteria 2GJMA@201174,4ESQ7@85013,COG2177@1,COG2177@2 NA|NA|NA D Part of the ABC transporter FtsEX involved in cellular division KOPIJCMJ_02637 768706.Desor_5488 2e-31 143.7 Peptococcaceae ko:K21471,ko:K21472 ko00000,ko01000,ko01002,ko01011 Bacteria 1VAC5@1239,25E3G@186801,267BP@186807,COG0739@1,COG0739@2,COG3883@1,COG3883@2 NA|NA|NA M PFAM Peptidase family M23 KOPIJCMJ_02638 330084.JNYZ01000010_gene6967 2.6e-56 224.9 Pseudonocardiales smpB GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0070930,GO:0071704,GO:0097159,GO:1901363,GO:1901564 ko:K03664 ko00000 Bacteria 2GJX1@201174,4E2R0@85010,COG0691@1,COG0691@2 NA|NA|NA O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA KOPIJCMJ_02640 479431.Namu_5044 5.2e-26 124.4 Frankiales Bacteria 2HF67@201174,4EWG3@85013,COG0477@1,COG2814@2 NA|NA|NA EGP Transmembrane secretion effector KOPIJCMJ_02641 1298863.AUEP01000003_gene2817 5e-78 297.7 Propionibacteriales fliR ko:K02421,ko:K03228,ko:K13820 ko02040,ko03070,map02040,map03070 M00332,M00542,M00660 ko00000,ko00001,ko00002,ko02035,ko02044 3.A.6.1,3.A.6.2,3.A.6.3 Bacteria 2IDEX@201174,4DPR0@85009,COG1684@1,COG1684@2 NA|NA|NA NU Bacterial export proteins, family 1 KOPIJCMJ_02642 397278.JOJN01000001_gene2924 4.7e-31 140.2 Propionibacteriales fliQ ko:K02420 ko02040,map02040 ko00000,ko00001,ko02035,ko02044 3.A.6.2 Bacteria 2IQ8H@201174,4DRPB@85009,COG1987@1,COG1987@2 NA|NA|NA NU Bacterial export proteins, family 3 KOPIJCMJ_02643 935866.JAER01000042_gene2756 4.9e-74 285.0 Propionibacteriales fliP ko:K02419,ko:K03226 ko02040,ko03070,map02040,map03070 M00332,M00542,M00660 ko00000,ko00001,ko00002,ko02035,ko02044 3.A.6.1,3.A.6.2,3.A.6.3 Bacteria 2GP63@201174,4DPT8@85009,COG1338@1,COG1338@2 NA|NA|NA NU FliP family KOPIJCMJ_02645 446471.Xcel_1961 1.4e-36 160.6 Bacteria Bacteria 2EA5X@1,334AT@2 NA|NA|NA KOPIJCMJ_02646 446471.Xcel_1962 5.1e-57 227.6 Actinobacteria Bacteria 28PII@1,2GTGX@201174,32WVR@2 NA|NA|NA S Protein of unknown function (DUF4255) KOPIJCMJ_02648 1146883.BLASA_3175 3.1e-46 191.8 Actinobacteria Bacteria 2GTXG@201174,COG2197@1,COG2197@2 NA|NA|NA K helix_turn_helix, Lux Regulon KOPIJCMJ_02649 1283287.KB822582_gene2945 2e-54 219.2 Actinobacteria Bacteria 2I7QR@201174,COG4803@1,COG4803@2 NA|NA|NA S Protein of unknown function (DUF1269) KOPIJCMJ_02650 298653.Franean1_6932 4.7e-125 454.9 Frankiales gntK GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0009987,GO:0030312,GO:0044464,GO:0044764,GO:0046812,GO:0051704,GO:0071944 2.3.1.82,2.7.1.12 ko:K00663,ko:K00851,ko:K07028 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 R01737 RC00002,RC00017 ko00000,ko00001,ko01000,ko01504 Bacteria 2GM3U@201174,4EUNB@85013,COG0645@1,COG0645@2,COG2187@1,COG2187@2 NA|NA|NA S AAA domain KOPIJCMJ_02652 1380370.JIBA01000011_gene3047 9.1e-151 539.7 Intrasporangiaceae ko:K04763 ko00000,ko03036 Bacteria 2ID5W@201174,4FFEX@85021,COG4974@1,COG4974@2 NA|NA|NA L Belongs to the 'phage' integrase family KOPIJCMJ_02656 1003195.SCAT_3486 1.4e-90 339.3 Actinobacteria nuoC GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0050136,GO:0055114 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2GIRH@201174,COG0852@1,COG0852@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient KOPIJCMJ_02657 1504319.GM45_4125 2.3e-85 321.6 unclassified Actinobacteria (class) nuoB 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2GJXR@201174,3UWJQ@52018,COG0377@1,COG0377@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient KOPIJCMJ_02658 436229.JOEH01000024_gene946 1.3e-50 205.7 Streptacidiphilus nuoA GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044464,GO:0050136,GO:0055114,GO:0071944,GO:0098796,GO:1902494 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2IKWT@201174,2NJ30@228398,COG0838@1,COG0838@2 NA|NA|NA C NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 KOPIJCMJ_02659 1120950.KB892779_gene972 3.3e-138 498.4 Propionibacteriales 1.3.99.38 ko:K21401 ko00000,ko01000 Bacteria 2GKGH@201174,4DPE1@85009,COG0644@1,COG0644@2 NA|NA|NA C FAD binding domain KOPIJCMJ_02660 479431.Namu_3208 0.0 1110.5 Actinobacteria pflB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006566,GO:0006567,GO:0006629,GO:0006631,GO:0006807,GO:0008150,GO:0008152,GO:0008861,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009987,GO:0016020,GO:0016054,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0016999,GO:0017144,GO:0019541,GO:0019752,GO:0032787,GO:0042737,GO:0043436,GO:0043875,GO:0044237,GO:0044238,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046459,GO:0070689,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.3.1.54 ko:K00656 ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120 R00212,R06987 RC00004,RC01181,RC02742,RC02833 ko00000,ko00001,ko01000 iECH74115_1262.ECH74115_1064,iECIAI39_1322.ECIAI39_2245,iECSP_1301.ECSP_1007,iECs_1301.ECs0986,iEcSMS35_1347.EcSMS35_2218,iEcSMS35_1347.EcSMS35_3410,iG2583_1286.G2583_1138,iSDY_1059.SDY_2358,iZ_1308.Z1248 Bacteria 2GTTT@201174,COG1882@1,COG1882@2 NA|NA|NA C formate acetyltransferase KOPIJCMJ_02661 1463887.KL589953_gene93 2.6e-66 258.8 Actinobacteria pflA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0018307,GO:0019538,GO:0033554,GO:0036211,GO:0043170,GO:0043364,GO:0043365,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0055114,GO:0070283,GO:0071704,GO:1901564 1.97.1.4 ko:K04069 R04710 ko00000,ko01000 iECOK1_1307.ECOK1_0925,iEcE24377_1341.EcE24377A_0980,iEcSMS35_1347.EcSMS35_2219,iYL1228.KPN_00930 Bacteria 2GN2B@201174,COG1180@1,COG1180@2 NA|NA|NA C Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine KOPIJCMJ_02662 452652.KSE_34280 2.3e-13 82.8 Kitasatospora Bacteria 2HRC6@201174,2M45I@2063,COG1280@1,COG1280@2 NA|NA|NA E Sap, sulfolipid-1-addressing protein KOPIJCMJ_02663 1137269.AZWL01000015_gene734 2.8e-94 351.7 Actinobacteria ubiE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008425,GO:0008757,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016741,GO:0030580,GO:0032259,GO:0042180,GO:0042181,GO:0043333,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 iAF1260.b3833,iBWG_1329.BWG_3511,iE2348C_1286.E2348C_4147,iEC042_1314.EC042_4213,iEC55989_1330.EC55989_4310,iECDH10B_1368.ECDH10B_4024,iECDH1ME8569_1439.ECDH1ME8569_3712,iECH74115_1262.ECH74115_5274,iECIAI1_1343.ECIAI1_4028,iECIAI39_1322.ECIAI39_3162,iECO103_1326.ECO103_4330,iECO111_1330.ECO111_4661,iECO26_1355.ECO26_4752,iECSE_1348.ECSE_4121,iECSP_1301.ECSP_4888,iECUMN_1333.ECUMN_4359,iECW_1372.ECW_m4135,iECs_1301.ECs4763,iEKO11_1354.EKO11_4524,iETEC_1333.ETEC_4110,iEcDH1_1363.EcDH1_4146,iEcE24377_1341.EcE24377A_4354,iEcHS_1320.EcHS_A4057,iEcSMS35_1347.EcSMS35_4216,iEcolC_1368.EcolC_4175,iG2583_1286.G2583_4633,iJO1366.b3833,iJR904.b3833,iSBO_1134.SBO_3847,iSDY_1059.SDY_3910,iSFV_1184.SFV_3665,iSF_1195.SF3911,iSFxv_1172.SFxv_4263,iSSON_1240.SSON_4008,iS_1188.S3843,iSbBS512_1146.SbBS512_E4305,iUMNK88_1353.UMNK88_4663,iWFL_1372.ECW_m4135,iY75_1357.Y75_RS17910,iZ_1308.Z5355 Bacteria 2GKFZ@201174,COG0500@1,COG2226@2 NA|NA|NA H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) KOPIJCMJ_02664 479435.Kfla_6301 1.6e-113 416.4 Propionibacteriales menF 2.6.1.85,4.1.3.27,5.4.4.2 ko:K01657,ko:K02552,ko:K13950 ko00130,ko00400,ko00405,ko00790,ko01053,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00130,map00400,map00405,map00790,map01053,map01100,map01110,map01130,map01230,map02024,map02025 M00023,M00116 R00985,R00986,R01716,R01717 RC00010,RC00588,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKE8@201174,4DPGF@85009,COG1169@1,COG1169@2 NA|NA|NA HQ Isochorismate synthase KOPIJCMJ_02665 1356852.N008_18865 2.9e-14 84.7 Cytophagia Bacteria 47RW1@768503,4NUPH@976,COG0607@1,COG0607@2 NA|NA|NA P Rhodanese Homology Domain KOPIJCMJ_02666 1380393.JHVP01000002_gene1924 1.8e-30 139.0 Frankiales menD GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 2.2.1.9 ko:K02551 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R08165 RC02186 ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS05085 Bacteria 2GMEB@201174,4ES4N@85013,COG1165@1,COG1165@2 NA|NA|NA H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) KOPIJCMJ_02670 1137269.AZWL01000042_gene1229 4e-37 162.2 Actinobacteria Bacteria 2DVVA@1,2IHH0@201174,32V07@2 NA|NA|NA KOPIJCMJ_02671 1121372.AULK01000004_gene1325 1.2e-21 111.3 Microbacteriaceae Bacteria 2GU7G@201174,4FMTP@85023,COG1403@1,COG1403@2 NA|NA|NA V Domain of unknown function (DUF222) KOPIJCMJ_02672 219305.MCAG_00437 5.8e-201 707.2 Micromonosporales pgi GO:0003674,GO:0003824,GO:0004347,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GJG0@201174,4DBW4@85008,COG0166@1,COG0166@2 NA|NA|NA G Belongs to the GPI family KOPIJCMJ_02673 446468.Ndas_1544 1.8e-141 509.2 Streptosporangiales cysS GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010125,GO:0010126,GO:0010467,GO:0016020,GO:0016070,GO:0016137,GO:0016138,GO:0016874,GO:0016875,GO:0016879,GO:0016880,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035446,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.1.1.16,6.3.1.13 ko:K01883,ko:K15526 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iNJ661.Rv2130c Bacteria 2GJZR@201174,4EH1Y@85012,COG0215@1,COG0215@2 NA|NA|NA J Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins KOPIJCMJ_02674 591157.SSLG_01071 2.1e-31 142.9 Actinobacteria surf1 ko:K14998 ko00000,ko03029 3.D.4.8 Bacteria 2GR90@201174,COG3346@1,COG3346@2 NA|NA|NA S SURF1-like protein KOPIJCMJ_02675 1035308.AQYY01000002_gene664 2.6e-32 145.6 Bacteria Bacteria COG5274@1,COG5274@2 NA|NA|NA C heme binding KOPIJCMJ_02676 1120950.KB892747_gene3703 1.1e-66 260.0 Propionibacteriales 3.1.3.10 ko:K07025,ko:K20866 ko00010,ko01120,map00010,map01120 R00947 RC00078 ko00000,ko00001,ko01000 Bacteria 2HZ7F@201174,4DQFA@85009,COG1011@1,COG1011@2 NA|NA|NA S HAD-superfamily hydrolase, subfamily IA, variant 1 KOPIJCMJ_02677 479431.Namu_2200 1.9e-240 838.6 Frankiales proS GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 2GJ9G@201174,4ERXH@85013,COG0442@1,COG0442@2 NA|NA|NA J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS KOPIJCMJ_02678 66377.JOBH01000024_gene3357 4.9e-79 301.2 Actinobacteria ko:K06976 ko00000 Bacteria 2GMD2@201174,COG3393@1,COG3393@2 NA|NA|NA S acetyltransferase KOPIJCMJ_02679 1123256.KB907927_gene1736 6e-87 327.8 Xanthomonadales adhA 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 Bacteria 1MUTT@1224,1RPQC@1236,1X31K@135614,COG1064@1,COG1064@2 NA|NA|NA S Alcohol dehydrogenase GroES-like domain KOPIJCMJ_02681 1306174.JODP01000021_gene193 2.9e-101 375.6 Actinobacteria ko:K06946 ko00000 Bacteria 2IES1@201174,COG3596@1,COG3596@2,COG3597@1,COG3597@2 NA|NA|NA D Domain of unknown function (DUF697) KOPIJCMJ_02682 40571.JOEA01000017_gene507 4.9e-178 630.6 Pseudonocardiales ispG GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009055,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0022900,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS06430,iJN678.gcpE Bacteria 2GK2S@201174,4DZX0@85010,COG0821@1,COG0821@2 NA|NA|NA I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate KOPIJCMJ_02683 1123052.AUDF01000012_gene812 1.1e-25 124.0 Microbacteriaceae ko:K07090 ko00000 Bacteria 2I5VT@201174,4FNYV@85023,COG0730@1,COG0730@2 NA|NA|NA S Sulfite exporter TauE/SafE KOPIJCMJ_02684 1074488.AGBX01000005_gene2701 3.7e-100 372.1 Dermabacteraceae rseP ko:K11749 ko02024,ko04112,map02024,map04112 ko00000,ko00001,ko01000,ko01002 Bacteria 2GJJT@201174,4FC68@85020,COG0750@1,COG0750@2 NA|NA|NA M Domain present in PSD-95, Dlg, and ZO-1/2. KOPIJCMJ_02685 1394178.AWOO02000089_gene1086 2e-110 405.6 Streptosporangiales dxr GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0050897,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 iAPECO1_1312.APECO1_1814,iECOK1_1307.ECOK1_0174,iECS88_1305.ECS88_0183,iHN637.CLJU_RS06420,iNJ661.Rv2870c,iUMN146_1321.UM146_23670,iUTI89_1310.UTI89_C0188 Bacteria 2GIRV@201174,4EGGZ@85012,COG0743@1,COG0743@2 NA|NA|NA I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) KOPIJCMJ_02687 345341.KUTG_04253 5e-138 497.7 Pseudonocardiales glgA GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901576 2.4.1.342 ko:K16148 ko00500,ko01100,map00500,map01100 R02421,R11530 RC00005,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 GT4 Bacteria 2I2EE@201174,4E0K3@85010,COG0297@1,COG0297@2 NA|NA|NA G Glycosyl transferase 4-like domain KOPIJCMJ_02688 397278.JOJN01000007_gene3359 6.3e-117 427.9 Propionibacteriales Bacteria 2GWA2@201174,2Z9VM@2,4DQ3R@85009,COG1524@1 NA|NA|NA S mannose-ethanolamine phosphotransferase activity KOPIJCMJ_02689 1146883.BLASA_0887 1e-55 223.4 Actinobacteria Bacteria 2GISN@201174,COG0582@1,COG0582@2 NA|NA|NA L Belongs to the 'phage' integrase family KOPIJCMJ_02690 1120950.KB892811_gene7249 8.8e-09 66.2 Propionibacteriales Bacteria 2GITW@201174,4DPHM@85009,COG1167@1,COG1167@2 NA|NA|NA K helix_turn_helix gluconate operon transcriptional repressor KOPIJCMJ_02691 479431.Namu_4120 9.8e-107 393.3 Frankiales ppk2 2.7.4.1 ko:K22468 ko00190,ko03018,map00190,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 2GKRN@201174,4EU1X@85013,COG2326@1,COG2326@2 NA|NA|NA S Polyphosphate kinase 2 (PPK2) KOPIJCMJ_02694 1123504.JQKD01000087_gene844 1.4e-17 95.1 Comamonadaceae Bacteria 1RJ6B@1224,2C06D@1,2VSUU@28216,32R6C@2,4AEU1@80864 NA|NA|NA KOPIJCMJ_02695 159087.Daro_2227 3.6e-29 135.2 Betaproteobacteria Bacteria 1RD6N@1224,29QVI@1,2VR3I@28216,30BVQ@2 NA|NA|NA KOPIJCMJ_02696 159087.Daro_2229 5.2e-71 274.2 Rhodocyclales Bacteria 1REA8@1224,2A0ES@1,2KZJ5@206389,2VQQB@28216,30NII@2 NA|NA|NA KOPIJCMJ_02697 1869.MB27_37345 3.5e-09 67.4 Micromonosporales moaD 2.8.1.12 ko:K03636,ko:K21142 ko00790,ko01100,ko04122,map00790,map01100,map04122 R09395 RC02507 ko00000,ko00001,ko01000 Bacteria 2IQIT@201174,4DFX3@85008,COG1977@1,COG1977@2 NA|NA|NA H ThiS family KOPIJCMJ_02698 1193181.BN10_1080031 2.6e-117 428.7 Intrasporangiaceae moaA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0030312,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0071944,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.22,4.6.1.17 ko:K03639,ko:K20967 ko00790,ko01100,ko04122,map00790,map01100,map04122 R09394,R11372 RC03420,RC03425 ko00000,ko00001,ko01000 Bacteria 2GN0V@201174,4FFGU@85021,COG2896@1,COG2896@2 NA|NA|NA H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate KOPIJCMJ_02699 1120934.KB894410_gene6919 1.3e-67 263.5 Pseudonocardiales moaE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.7.7.80,2.8.1.11,2.8.1.12,4.6.1.17 ko:K03635,ko:K03637,ko:K21147 ko00790,ko01100,ko04122,map00790,map01100,map04122 R07459,R07461,R09395,R11372 RC00043,RC02507,RC03425 ko00000,ko00001,ko01000 Bacteria 2II28@201174,4DZNU@85010,COG0314@1,COG0314@2,COG0521@1,COG0521@2 NA|NA|NA H TIGRFAM molybdenum cofactor synthesis KOPIJCMJ_02700 1121946.AUAX01000006_gene3402 1.9e-43 182.2 Micromonosporales moaC 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 R11372 RC03425 ko00000,ko00001,ko01000 Bacteria 2IHR6@201174,4DDCJ@85008,COG0315@1,COG0315@2,COG0521@1,COG0521@2 NA|NA|NA H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) KOPIJCMJ_02701 465541.ATCJ01000005_gene4299 1.7e-44 186.4 Actinobacteria mobA 2.7.7.77 ko:K03752 ko00790,ko01100,map00790,map01100 R11581 ko00000,ko00001,ko01000 Bacteria 2GJVE@201174,COG0746@1,COG0746@2 NA|NA|NA H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor KOPIJCMJ_02702 390989.JOEG01000004_gene3799 1.9e-84 319.7 Micromonosporales mog 2.10.1.1,2.8.1.12,4.6.1.17 ko:K03635,ko:K03637,ko:K03750 ko00790,ko01100,ko04122,map00790,map01100,map04122 R09395,R09735,R11372 RC02507,RC03425,RC03462 ko00000,ko00001,ko01000 Bacteria 2GP1B@201174,4DBSX@85008,COG0303@1,COG0303@2,COG0521@1,COG0521@2 NA|NA|NA H Probable molybdopterin binding domain KOPIJCMJ_02703 590998.Celf_1257 6.5e-172 610.5 Cellulomonadaceae narU ko:K02575 ko00910,map00910 M00615 ko00000,ko00001,ko00002,ko02000 2.A.1.8 iNJ661.Rv0267 Bacteria 2GJ1I@201174,4F0H3@85016,COG2223@1,COG2223@2 NA|NA|NA P PFAM major facilitator superfamily MFS_1 KOPIJCMJ_02704 471853.Bcav_2801 7.7e-294 1016.1 Actinobacteria nasC ko:K00372 ko00910,ko01120,map00910,map01120 M00531 R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 Bacteria 2HC9H@201174,COG3383@1,COG3383@2 NA|NA|NA C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family KOPIJCMJ_02705 935839.JAGJ01000004_gene1928 7.9e-126 457.6 Promicromonosporaceae nasC 1.7.1.15 ko:K00360,ko:K00362 ko00910,ko01120,map00910,map01120 M00530,M00531 R00787,R00798 RC00176,RC02812 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ3U@201174,4F3YI@85017,COG1251@1,COG1251@2 NA|NA|NA C BFD-like [2Fe-2S] binding domain KOPIJCMJ_02706 1385518.N798_06760 0.0 1274.6 Intrasporangiaceae nirB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006091,GO:0008150,GO:0008152,GO:0008942,GO:0009061,GO:0009344,GO:0009987,GO:0015980,GO:0016491,GO:0016661,GO:0020037,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044464,GO:0045333,GO:0046857,GO:0046906,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0051536,GO:0051540,GO:0055114,GO:0097159,GO:0098809,GO:1901265,GO:1901363 1.7.1.15 ko:K00362 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 iECIAI39_1322.ECIAI39_3849 Bacteria 2GJ3U@201174,4FF81@85021,COG1251@1,COG1251@2 NA|NA|NA C Belongs to the nitrite and sulfite reductase 4Fe-4S domain family KOPIJCMJ_02707 1385519.N801_03455 8.5e-31 139.8 Intrasporangiaceae nirD GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006091,GO:0008150,GO:0008152,GO:0008942,GO:0009061,GO:0009344,GO:0009987,GO:0015980,GO:0016491,GO:0016661,GO:0032991,GO:0044237,GO:0044424,GO:0044464,GO:0045333,GO:0046857,GO:0055114,GO:0098809 1.7.1.15 ko:K00362,ko:K00363,ko:K05710 ko00360,ko00910,ko01120,ko01220,map00360,map00910,map01120,map01220 M00530,M00545 R00787,R06782,R06783 RC00098,RC00176 br01602,ko00000,ko00001,ko00002,ko01000 iEC55989_1330.EC55989_3772 Bacteria 2IQM4@201174,4FHUA@85021,COG2146@1,COG2146@2 NA|NA|NA P Rieske-like [2Fe-2S] domain KOPIJCMJ_02708 1380354.JIAN01000005_gene1238 1.4e-75 289.7 Cellulomonadaceae cysG GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009628,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.13.11.79,1.3.1.76,2.1.1.107,2.1.1.131,3.7.1.12,4.99.1.4 ko:K02302,ko:K02303,ko:K02304,ko:K04719,ko:K13541 ko00740,ko00860,ko01100,ko01110,ko01120,map00740,map00860,map01100,map01110,map01120 M00121 R02864,R03194,R03947,R05180,R05809,R07772,R09083 RC00003,RC00435,RC00871,RC01012,RC01034,RC01293,RC01545,RC02097,RC02413,RC03471 ko00000,ko00001,ko00002,ko01000 iECIAI1_1343.ECIAI1_3507,iECSE_1348.ECSE_3630,iEcE24377_1341.EcE24377A_3838,iJN746.PP_3999,iPC815.YPO0158 Bacteria 2GK3B@201174,4F260@85016,COG0007@1,COG0007@2,COG1648@1,COG1648@2 NA|NA|NA H PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase KOPIJCMJ_02709 1713.JOFV01000003_gene1528 1.9e-129 469.2 Cellulomonadaceae hemD 2.1.1.107,4.2.1.75 ko:K01719,ko:K13542 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165,R03194 RC00003,RC00871,RC01861 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKMM@201174,4F0R3@85016,COG0745@1,COG0745@2,COG1587@1,COG1587@2 NA|NA|NA HK PFAM Uroporphyrinogen III synthase HEM4 KOPIJCMJ_02711 1125971.ASJB01000074_gene74 1.3e-35 156.4 Pseudonocardiales Bacteria 2IKXB@201174,4E3FU@85010,COG4226@1,COG4226@2 NA|NA|NA S protein encoded in hypervariable junctions of pilus gene clusters KOPIJCMJ_02712 680198.SCAB_86811 8e-08 63.2 Actinobacteria Bacteria 2GJZC@201174,COG3595@1,COG3595@2 NA|NA|NA S Putative adhesin KOPIJCMJ_02713 208439.AJAP_13005 3.1e-101 375.2 Pseudonocardiales ko:K01990,ko:K18232 ko02010,map02010 M00254,M00634 ko00000,ko00001,ko00002,ko01504,ko02000 3.A.1,3.A.1.105.2 Bacteria 2GIY8@201174,4DXJX@85010,COG1131@1,COG1131@2 NA|NA|NA V Part of the ABC transporter complex DrrAB involved in daunorubicin and doxorubicin resistance. Responsible for energy coupling to the transport system. Binds ATP or GTP KOPIJCMJ_02714 298654.FraEuI1c_2160 2e-69 269.2 Frankiales ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GIVW@201174,4ERFD@85013,COG0842@1,COG0842@2 NA|NA|NA V PFAM ABC-2 type transporter KOPIJCMJ_02715 28444.JODQ01000006_gene351 3.5e-17 95.1 Streptosporangiales ko:K03088 ko00000,ko03021 Bacteria 2IRNG@201174,4EJSS@85012,COG1595@1,COG1595@2 NA|NA|NA K Sigma-70, region 4 KOPIJCMJ_02718 235985.BBPN01000004_gene3182 9.4e-30 136.0 Streptacidiphilus lolD ko:K02003 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GM25@201174,2NFXP@228398,COG1136@1,COG1136@2 NA|NA|NA V ATPases associated with a variety of cellular activities KOPIJCMJ_02721 1229203.KI301992_gene148 8.9e-88 330.1 unclassified Actinobacteria (class) hemL GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016853,GO:0016866,GO:0016869,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042286,GO:0042440,GO:0042802,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 iSB619.SA_RS08395,iUMNK88_1353.UMNK88_158 Bacteria 2GJSH@201174,3UW7J@52018,COG0001@1,COG0001@2 NA|NA|NA H Glutamate-1-semialdehyde aminotransferase KOPIJCMJ_02722 105420.BBPO01000037_gene311 2.5e-75 288.5 Streptacidiphilus GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 3.1.3.3,3.1.3.73 ko:K02226,ko:K22305 ko00260,ko00680,ko00860,ko01100,ko01120,ko01130,map00260,map00680,map00860,map01100,map01120,map01130 M00122 R00582,R04594,R11173 RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 2GMXF@201174,2NFB7@228398,COG0406@1,COG0406@2 NA|NA|NA G Phosphoglycerate mutase family KOPIJCMJ_02723 269800.Tfu_2704 1.1e-43 183.3 Streptosporangiales resA ko:K02199 ko00000,ko03110 Bacteria 2GP7J@201174,4EJ9T@85012,COG0526@1,COG0526@2 NA|NA|NA CO Thioredoxin-like KOPIJCMJ_02724 1236902.ANAS01000019_gene4144 2.5e-73 282.3 Streptosporangiales ccdA ko:K06196 ko00000,ko02000 5.A.1.2 Bacteria 2GJW3@201174,4EHWN@85012,COG0785@1,COG0785@2 NA|NA|NA O Cytochrome C biogenesis protein transmembrane region KOPIJCMJ_02725 1120950.KB892801_gene1786 4.2e-127 461.8 Propionibacteriales resB ko:K07399 ko00000 Bacteria 2GMGH@201174,4DN12@85009,COG1333@1,COG1333@2 NA|NA|NA O ResB-like family KOPIJCMJ_02726 1048339.KB913029_gene2342 2.2e-79 302.8 Frankiales ccsA GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008152,GO:0015886,GO:0016020,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0055114,GO:0071702,GO:0071705,GO:0071944,GO:1901678 Bacteria 2GJR1@201174,4ESE9@85013,COG0755@1,COG0755@2 NA|NA|NA O Cytochrome c-type biogenesis protein KOPIJCMJ_02728 1120950.KB892801_gene1792 6.1e-12 77.4 Propionibacteriales Bacteria 2EGDD@1,2HKYH@201174,33A58@2,4DSSA@85009 NA|NA|NA S Phospholipase_D-nuclease N-terminal KOPIJCMJ_02729 158189.SpiBuddy_1062 2.8e-50 204.9 Spirochaetes btuE 1.11.1.9 ko:K00432 ko00480,ko00590,ko04918,map00480,map00590,map04918 R00274,R07034,R07035 RC00011,RC00982 ko00000,ko00001,ko01000 Bacteria 2J843@203691,COG0386@1,COG0386@2 NA|NA|NA C Belongs to the glutathione peroxidase family KOPIJCMJ_02730 1184609.KILIM_039_00360 6.1e-83 314.3 Dermatophilaceae menA GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006775,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009233,GO:0009234,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0032194,GO:0042180,GO:0042181,GO:0042362,GO:0042371,GO:0042373,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046428,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663 2.5.1.74 ko:K02548 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R05617,R06858,R10757 RC02935,RC02936,RC03264 ko00000,ko00001,ko00002,ko01000,ko01006 iECH74115_1262.ECH74115_5387,iG2583_1286.G2583_4737 Bacteria 2GJBS@201174,4F6JM@85018,COG1575@1,COG1575@2 NA|NA|NA H Belongs to the MenA family. Type 1 subfamily KOPIJCMJ_02731 1273125.Rrhod_1412 6.8e-53 214.9 Nocardiaceae menE 6.2.1.26 ko:K01911 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R04030 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 Bacteria 2GN9C@201174,4FUUX@85025,COG0318@1,COG0318@2 NA|NA|NA IQ AMP-binding enzyme C-terminal domain KOPIJCMJ_02732 644548.SCNU_19462 8.7e-129 466.8 Gordoniaceae ybhS ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GJ7Y@201174,4GCQ2@85026,COG0842@1,COG0842@2 NA|NA|NA U ABC-2 family transporter protein KOPIJCMJ_02733 1454010.JEOE01000004_gene138 2.5e-83 315.5 Cellulomonadaceae ybhF GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015562,GO:0015893,GO:0016020,GO:0022857,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944 ko:K01990,ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2IH64@201174,4F2FJ@85016,COG1131@1,COG1131@2 NA|NA|NA V ATPases associated with a variety of cellular activities KOPIJCMJ_02734 1095767.CAHD01000200_gene2345 3.9e-82 311.6 Cellulomonadaceae ybhF GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015562,GO:0015893,GO:0016020,GO:0022857,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944 ko:K01990,ko:K01992,ko:K13926 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2ICIF@201174,4F24V@85016,COG1131@1,COG1131@2 NA|NA|NA V ABC transporter KOPIJCMJ_02735 590998.Celf_1669 2.5e-38 165.6 Cellulomonadaceae pabB 2.6.1.85,2.7.1.48,4.1.3.27 ko:K00876,ko:K01657,ko:K13950 ko00240,ko00400,ko00405,ko00790,ko00983,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00240,map00400,map00405,map00790,map00983,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R00985,R00986,R01548,R01549,R01716,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232 RC00002,RC00010,RC00017,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 Bacteria 2HQC8@201174,4F1E0@85016,COG0572@1,COG0572@2 NA|NA|NA F uridine kinase KOPIJCMJ_02736 68194.JNXR01000005_gene4786 8.7e-10 69.3 Actinobacteria Bacteria 2GME7@201174,COG5032@1,COG5032@2 NA|NA|NA BDLTU Phosphatidylinositol KOPIJCMJ_02737 345341.KUTG_00976 1.4e-88 334.0 Pseudonocardiales Bacteria 2GIZF@201174,4DYN9@85010,COG5001@1,COG5001@2 NA|NA|NA T Diguanylate cyclase KOPIJCMJ_02738 1463858.JOHR01000014_gene5354 3.4e-125 455.3 Actinobacteria rnd 3.1.13.5 ko:K03684 ko00000,ko01000,ko03016 Bacteria 2GKNM@201174,COG0349@1,COG0349@2 NA|NA|NA J 3-5 exonuclease KOPIJCMJ_02739 1137271.AZUM01000001_gene1482 2.3e-25 122.5 Pseudonocardiales Bacteria 2GIXT@201174,4DXKI@85010,COG2197@1,COG2197@2 NA|NA|NA K response regulator KOPIJCMJ_02740 1298863.AUEP01000018_gene3870 2.2e-54 218.8 Propionibacteriales Bacteria 2AIF4@1,2GK8R@201174,318WM@2,4DQE6@85009 NA|NA|NA S Protein of unknown function (DUF3000) KOPIJCMJ_02741 1385519.N801_01520 1.7e-47 196.4 Intrasporangiaceae Bacteria 2GM50@201174,4FGFA@85021,COG0697@1,COG0697@2 NA|NA|NA EG EamA-like transporter family KOPIJCMJ_02743 1304865.JAGF01000001_gene2261 5e-180 637.1 Actinobacteria bglH 3.2.1.86 ko:K01223 ko00010,ko00500,map00010,map00500 R00839,R05133,R05134 RC00049,RC00171,RC00714 ko00000,ko00001,ko01000 GT1 Bacteria 2GJAF@201174,COG2723@1,COG2723@2 NA|NA|NA G Belongs to the glycosyl hydrolase 1 family KOPIJCMJ_02744 1178540.BA70_17750 1.4e-49 203.4 Bacillus ko:K02538,ko:K03488 ko00000,ko03000 Bacteria 1TQJJ@1239,1ZMHP@1386,4HBB3@91061,COG3711@1,COG3711@2 NA|NA|NA K CAT RNA binding domain KOPIJCMJ_02745 1122130.AUHN01000009_gene584 3e-140 505.8 Actinobacteria bglF ko:K02755,ko:K02756,ko:K02757 ko02060,map02060 M00271 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.2.11,4.A.1.2.2,4.A.1.2.5,4.A.1.2.6 Bacteria 2GK6B@201174,COG1263@1,COG1263@2,COG1264@1,COG1264@2,COG2190@1,COG2190@2 NA|NA|NA G Pts system KOPIJCMJ_02746 998088.B565_0889 3.8e-26 124.8 Gammaproteobacteria Bacteria 1RB8R@1224,1S1A6@1236,COG1051@1,COG1051@2 NA|NA|NA F COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes KOPIJCMJ_02747 1500257.JQNM01000020_gene2569 3.2e-43 181.4 Rhizobiaceae Bacteria 1N7IY@1224,2U993@28211,4BFSP@82115,COG3865@1,COG3865@2 NA|NA|NA S 3-demethylubiquinone-9 3-methyltransferase KOPIJCMJ_02748 1504319.GM45_4930 3.2e-87 327.8 unclassified Actinobacteria (class) sigA ko:K03086 ko00000,ko03021 Bacteria 2GK3Z@201174,3UWCE@52018,COG0568@1,COG0568@2 NA|NA|NA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released KOPIJCMJ_02749 1123320.KB889688_gene406 1.6e-251 875.2 Actinobacteria sdhA GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0043436,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071704,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0072350,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 iE2348C_1286.E2348C_0603,iJN746.PP_4191,iPC815.YPO1111 Bacteria 2GJ45@201174,COG1053@1,COG1053@2 NA|NA|NA C succinate dehydrogenase KOPIJCMJ_02750 1122138.AQUZ01000008_gene3765 1.8e-208 731.9 Propionibacteriales Bacteria 2GJK7@201174,4DTG9@85009,COG3464@1,COG3464@2 NA|NA|NA L Transposase KOPIJCMJ_02751 1217658.F987_02722 8.4e-16 91.7 Moraxellaceae Bacteria 1QVSC@1224,1SRBM@1236,3NR5W@468,COG3979@1,COG3979@2 NA|NA|NA S chitinase KOPIJCMJ_02752 710111.FraQA3DRAFT_3461 7e-25 120.6 Actinobacteria ko:K03088 ko00000,ko03021 Bacteria 2IKVM@201174,COG1595@1,COG1595@2 NA|NA|NA K belongs to the sigma-70 factor family, ECF subfamily KOPIJCMJ_02754 1123052.AUDF01000002_gene687 1.1e-21 110.2 Microbacteriaceae Bacteria 2B212@1,2HTBX@201174,31UHT@2,4FSXA@85023 NA|NA|NA KOPIJCMJ_02755 1380370.JIBA01000011_gene3047 1.2e-150 539.3 Intrasporangiaceae ko:K04763 ko00000,ko03036 Bacteria 2ID5W@201174,4FFEX@85021,COG4974@1,COG4974@2 NA|NA|NA L Belongs to the 'phage' integrase family KOPIJCMJ_02756 1385520.N802_11490 1.2e-28 132.1 Intrasporangiaceae Bacteria 2E8MQ@1,2ISX4@201174,332Z5@2,4FHDD@85021 NA|NA|NA S Ribbon-helix-helix protein, copG family KOPIJCMJ_02757 1348338.ADILRU_1152 2.6e-25 120.9 Microbacteriaceae Bacteria 2C7CU@1,2IRTH@201174,33J7G@2,4FSJC@85023 NA|NA|NA KOPIJCMJ_02759 1298863.AUEP01000020_gene3640 1e-37 162.5 Actinobacteria 2.3.1.128 ko:K03790 ko00000,ko01000,ko03009 Bacteria 2IQZC@201174,COG2329@1,COG2329@2 NA|NA|NA S Antibiotic biosynthesis monooxygenase KOPIJCMJ_02760 1223523.H340_07753 5.8e-61 240.7 Actinobacteria Bacteria 2GMX2@201174,COG3382@1,COG3382@2 NA|NA|NA S B3 4 domain KOPIJCMJ_02762 446466.Cfla_3439 4.1e-99 367.9 Cellulomonadaceae hemB GO:0000287,GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 iECABU_c1320.ECABU_c04500,iEcSMS35_1347.EcSMS35_0398,iJN746.PP_2913,ic_1306.c0477 Bacteria 2GJJ0@201174,4F0TK@85016,COG0113@1,COG0113@2 NA|NA|NA H Belongs to the ALAD family KOPIJCMJ_02763 1122611.KB904029_gene5405 3.8e-50 204.5 Streptosporangiales scpB ko:K06024 ko00000,ko03036 Bacteria 2GISY@201174,4EG7D@85012,COG1386@1,COG1386@2 NA|NA|NA K Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves KOPIJCMJ_02764 1184607.AUCHE_05_03990 2.2e-83 315.5 Dermatophilaceae rluB GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.19,5.4.99.22 ko:K06178,ko:K06183 ko00000,ko01000,ko03009 Bacteria 2GJ4N@201174,4F65G@85018,COG1187@1,COG1187@2 NA|NA|NA J RNA pseudouridylate synthase KOPIJCMJ_02765 1463881.KL591011_gene2890 7.2e-35 153.3 Actinobacteria aroH GO:0003674,GO:0003824,GO:0004106,GO:0006082,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016866,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044281,GO:0046417,GO:0071704 2.7.4.25,5.4.99.5 ko:K00945,ko:K06208 ko00240,ko00400,ko01100,ko01110,ko01130,ko01230,map00240,map00400,map01100,map01110,map01130,map01230 M00024,M00025,M00052 R00158,R00512,R01665,R01715 RC00002,RC03116 ko00000,ko00001,ko00002,ko01000 Bacteria 2IHWT@201174,COG4401@1,COG4401@2 NA|NA|NA E Chorismate mutase KOPIJCMJ_02766 1210046.B277_08400 4.7e-82 311.6 Intrasporangiaceae tyrA 1.3.1.12,1.3.1.43 ko:K00210,ko:K00220,ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025,M00040 R00732,R01728 RC00125 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKB4@201174,4FF8J@85021,COG0287@1,COG0287@2 NA|NA|NA E Prephenate dehydrogenase KOPIJCMJ_02767 1229203.KI301992_gene1081 1e-56 226.9 unclassified Actinobacteria (class) cmk GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 ko:K00945,ko:K03977 ko00240,ko01100,map00240,map01100 M00052 R00158,R00512,R01665 RC00002 ko00000,ko00001,ko00002,ko01000,ko03009 Bacteria 2H3SI@201174,3UWT7@52018,COG0283@1,COG0283@2 NA|NA|NA F Cytidylate kinase KOPIJCMJ_02768 1463856.JOHY01000043_gene7260 3.9e-183 647.9 Actinobacteria der GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 1.1.1.399,1.1.1.95 ko:K00058,ko:K03977 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko03009,ko04147 Bacteria 2GJ8J@201174,COG1160@1,COG1160@2 NA|NA|NA F GTPase that plays an essential role in the late steps of ribosome biogenesis KOPIJCMJ_02769 1043493.BBLU01000021_gene657 3.1e-54 218.0 Actinobacteria ko:K06929 ko00000 Bacteria 2IJYY@201174,COG1832@1,COG1832@2 NA|NA|NA S PFAM CoA-binding domain protein KOPIJCMJ_02771 1122175.ATXU01000013_gene512 2.1e-132 478.4 Microbacteriaceae Bacteria 2HSEE@201174,4FMYZ@85023,COG0582@1,COG0582@2 NA|NA|NA L viral genome integration into host DNA KOPIJCMJ_02772 1123320.KB889585_gene1745 4.8e-81 308.5 Actinobacteria rsmC ko:K00612 ko00000,ko01000 Bacteria 2GJPP@201174,COG2890@1,COG2890@2 NA|NA|NA J methyltransferase KOPIJCMJ_02773 2002.JOEQ01000018_gene7693 2.2e-268 931.8 Streptosporangiales hppA 3.6.1.1 ko:K15987 ko00190,map00190 ko00000,ko00001,ko01000 3.A.10.1 Bacteria 2GN8B@201174,4EGGE@85012,COG3808@1,COG3808@2 NA|NA|NA C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force KOPIJCMJ_02774 47716.JOFH01000021_gene4179 4e-15 87.8 Actinobacteria 2.7.11.1 ko:K04757 ko00000,ko01000,ko01001,ko03021 Bacteria 2IHNR@201174,COG2172@1,COG2172@2 NA|NA|NA T anti-sigma regulatory factor KOPIJCMJ_02775 106370.Francci3_4302 9.3e-21 106.3 Frankiales rsbV GO:0003674,GO:0005488,GO:0005515,GO:0042802 ko:K04749 ko00000,ko03021 Bacteria 2IHQG@201174,4ESTZ@85013,COG1366@1,COG1366@2 NA|NA|NA T Belongs to the anti-sigma-factor antagonist family KOPIJCMJ_02776 1463887.KL590002_gene4201 4.4e-20 104.8 Actinobacteria Bacteria 2IIEK@201174,COG1670@1,COG1670@2 NA|NA|NA J Acetyltransferase (GNAT) domain KOPIJCMJ_02777 1157632.AQWQ01000003_gene1787 3.3e-176 624.8 Actinobacteria cca 2.7.7.19,2.7.7.72 ko:K00970,ko:K00974 ko03013,ko03018,map03013,map03018 R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016,ko03019 Bacteria 2GMT1@201174,COG0617@1,COG0617@2 NA|NA|NA J tRNA nucleotidyltransferase poly(A) polymerase KOPIJCMJ_02778 675635.Psed_6673 8.7e-49 200.7 Pseudonocardiales Bacteria 2I2DG@201174,4E30H@85010,COG1051@1,COG1051@2 NA|NA|NA F Belongs to the Nudix hydrolase family KOPIJCMJ_02779 1048339.KB913029_gene1652 7.5e-55 222.2 Frankiales Bacteria 2GN00@201174,4ESX8@85013,COG3170@1,COG3170@2 NA|NA|NA NU Tfp pilus assembly protein FimV KOPIJCMJ_02780 1120950.KB892740_gene2537 6.2e-108 398.3 Propionibacteriales murJ ko:K03980 ko00000,ko01011,ko02000 2.A.66.4 Bacteria 2GKN0@201174,4DNJI@85009,COG0728@1,COG0728@2 NA|NA|NA KLT MviN-like protein KOPIJCMJ_02782 1120950.KB892740_gene2536 2.3e-55 223.4 Propionibacteriales Bacteria 2GM4A@201174,4DN49@85009,COG0515@1,COG0515@2 NA|NA|NA KLT serine threonine protein kinase KOPIJCMJ_02783 1184609.KILIM_019_00760 1.3e-128 466.1 Dermatophilaceae trxB GO:0000166,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.9,4.3.1.9 ko:K00384,ko:K22345 ko00030,ko00450,map00030,map00450 R01544,R02016,R03596,R09372 RC00013,RC00544,RC02518,RC02873 ko00000,ko00001,ko01000 iPC815.YPO1374 Bacteria 2GKD2@201174,4F6I4@85018,COG0492@1,COG0492@2 NA|NA|NA O Pyridine nucleotide-disulphide oxidoreductase KOPIJCMJ_02784 67315.JOBD01000019_gene7672 2.1e-38 164.9 Actinobacteria trxA GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.8.1.8 ko:K03671,ko:K03672 ko04621,ko05418,map04621,map05418 ko00000,ko00001,ko01000,ko03110 Bacteria 2IQ9T@201174,COG3118@1,COG3118@2 NA|NA|NA O belongs to the thioredoxin family KOPIJCMJ_02785 1048339.KB913029_gene1659 6.4e-90 337.8 Frankiales cwlM GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 3.2.1.17,3.5.1.28 ko:K01185,ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 Bacteria 2GPA9@201174,4ERBQ@85013,COG0860@1,COG0860@2,COG3409@1,COG3409@2 NA|NA|NA M Cell wall hydrolase autolysin KOPIJCMJ_02786 1032480.MLP_35050 8.1e-15 89.4 Propionibacteriales Bacteria 2IBN6@201174,4DP5E@85009,COG1502@1,COG1502@2 NA|NA|NA I PLD-like domain KOPIJCMJ_02788 1454010.JEOE01000029_gene3028 5.9e-151 540.8 Cellulomonadaceae avtA ko:K05825 ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210 R01939 RC00006 ko00000,ko00001,ko01000 Bacteria 2GITW@201174,4F2B4@85016,COG1167@1,COG1167@2 NA|NA|NA EK Aminotransferase class I and II KOPIJCMJ_02789 471852.Tcur_4976 8.6e-96 357.1 Streptosporangiales ddl 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 Bacteria 2GRWM@201174,4EFUD@85012,COG1181@1,COG1181@2 NA|NA|NA M Belongs to the D-alanine--D-alanine ligase family KOPIJCMJ_02790 443218.AS9A_0015 1.1e-06 60.8 Actinobacteria Bacteria 291QM@1,2H0PF@201174,2ZPAP@2 NA|NA|NA KOPIJCMJ_02791 1121385.AQXW01000004_gene2687 8.8e-89 333.6 Dermacoccaceae parB GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005694,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0060187,GO:0071944 ko:K03497 ko00000,ko03000,ko03036,ko04812 Bacteria 1ZVBH@145357,2GNRN@201174,COG1475@1,COG1475@2 NA|NA|NA K Belongs to the ParB family KOPIJCMJ_02792 110319.CF8_2111 7e-101 374.0 Propionibacteriales cphA 6.3.2.13,6.3.2.29,6.3.2.30 ko:K01928,ko:K03802 ko00300,ko00550,map00300,map00550 R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 Bacteria 2GN0U@201174,4DP39@85009,COG0189@1,COG0189@2,COG0769@1,COG0769@2 NA|NA|NA HJM RimK-like ATP-grasp domain KOPIJCMJ_02793 1298863.AUEP01000005_gene2400 1.6e-105 390.2 Propionibacteriales murE 6.3.2.13,6.3.2.29,6.3.2.30 ko:K01928,ko:K03802 ko00300,ko00550,map00300,map00550 R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 Bacteria 2GME3@201174,4DPYG@85009,COG0769@1,COG0769@2 NA|NA|NA M Mur ligase middle domain KOPIJCMJ_02795 1123322.KB904673_gene2958 3.2e-42 178.3 Actinobacteria nuoH 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 iNJ661.Rv3152 Bacteria 2GIVY@201174,COG1005@1,COG1005@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone KOPIJCMJ_02796 1504319.GM45_4160 3.5e-68 264.6 unclassified Actinobacteria (class) nuoI GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.6.5.3 ko:K00337,ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 iNJ661.Rv3153 Bacteria 2GJNU@201174,3UWSS@52018,COG1143@1,COG1143@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient KOPIJCMJ_02797 1194972.MVAC_02599 1.1e-65 256.9 Mycobacteriaceae nuoJ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 233A9@1762,2GKRS@201174,COG0839@1,COG0839@2 NA|NA|NA C Belongs to the complex I subunit 6 family KOPIJCMJ_02798 1120936.KB907213_gene4917 2.1e-32 144.8 Streptosporangiales nuoK GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3 ko:K00340,ko:K05576 ko00190,ko01100,map00190,map01100 M00144,M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2IKV7@201174,4EJPX@85012,COG0713@1,COG0713@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient KOPIJCMJ_02799 247156.NFA_26570 3.1e-225 788.1 Nocardiaceae nuoL GO:0008150,GO:0009605,GO:0009607,GO:0043207,GO:0044403,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0075136 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2GIT4@201174,4FWHS@85025,COG1009@1,COG1009@2 NA|NA|NA CP NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus KOPIJCMJ_02802 1048339.KB913029_gene3420 1.7e-49 202.2 Frankiales mce 5.1.99.1 ko:K05606 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R02765,R09979 RC00780,RC02739 ko00000,ko00001,ko00002,ko01000 Bacteria 2IIPR@201174,4ESUP@85013,COG0346@1,COG0346@2 NA|NA|NA E PFAM Glyoxalase bleomycin resistance protein dioxygenase KOPIJCMJ_02803 345341.KUTG_06459 2.4e-167 595.1 Pseudonocardiales fadA4 GO:0003674,GO:0003824,GO:0003988,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044403,GO:0044419,GO:0044464,GO:0046395,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:0075136,GO:1901575 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GJAC@201174,4DYM7@85010,COG0183@1,COG0183@2 NA|NA|NA I Belongs to the thiolase family KOPIJCMJ_02804 1894.JOER01000007_gene6468 5.8e-108 397.5 Actinobacteria ko:K07588 ko00000,ko01000 Bacteria 2GME8@201174,COG1703@1,COG1703@2 NA|NA|NA E LAO AO transport system ATPase KOPIJCMJ_02805 1289387.AUKW01000008_gene4681 7.3e-215 753.4 Actinobacteria icmA 5.4.99.2 ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 Bacteria 2GM65@201174,COG1884@1,COG1884@2 NA|NA|NA I Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly KOPIJCMJ_02806 1306174.JODP01000018_gene4385 2.5e-71 275.8 Actinobacteria trxA2 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 ko:K03671,ko:K05838 ko04621,ko05418,map04621,map05418 ko00000,ko00001,ko03110 Bacteria 2GJ7B@201174,COG3118@1,COG3118@2 NA|NA|NA O Thioredoxin KOPIJCMJ_02807 1123320.KB889709_gene8400 0.0 1079.3 Actinobacteria glgB GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901576 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 ko00000,ko00001,ko00002,ko01000,ko04147 CBM48,GH13 Bacteria 2GJ5C@201174,COG0296@1,COG0296@2 NA|NA|NA G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position KOPIJCMJ_02808 471852.Tcur_3583 3.8e-210 738.0 Streptosporangiales glgE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.4.99.16 ko:K16147 ko00500,ko01100,map00500,map01100 R09994 ko00000,ko00001,ko01000 GH13 Bacteria 2GJKR@201174,4EG8Q@85012,COG0366@1,COG0366@2 NA|NA|NA G Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB KOPIJCMJ_02809 1123320.KB889709_gene8414 8.8e-266 922.9 Actinobacteria glgX 3.2.1.196,3.2.1.68 ko:K01214,ko:K02438 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02111,R09995,R11261 ko00000,ko00001,ko00002,ko01000 CBM48,GH13 Bacteria 2GJ00@201174,COG1523@1,COG1523@2 NA|NA|NA G Belongs to the glycosyl hydrolase 13 family KOPIJCMJ_02810 269800.Tfu_0590 5.4e-75 287.7 Streptosporangiales echA17 GO:0003674,GO:0003824,GO:0004300,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJW5@201174,4EH13@85012,COG1024@1,COG1024@2 NA|NA|NA I Enoyl-CoA hydratase/isomerase KOPIJCMJ_02811 1171373.PACID_16570 2.2e-49 202.2 Propionibacteriales pgsA GO:0003674,GO:0003824,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 Bacteria 2GM3F@201174,4DQ8M@85009,COG0558@1,COG0558@2 NA|NA|NA I Belongs to the CDP-alcohol phosphatidyltransferase class-I family KOPIJCMJ_02812 58123.JOFJ01000007_gene696 1e-281 976.1 Streptosporangiales mpg 1.6.5.5,2.7.7.13,5.4.2.10,5.4.2.2,5.4.2.8 ko:K00344,ko:K00966,ko:K01840,ko:K03431,ko:K15778,ko:K16881 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114,M00361,M00362 R00885,R00959,R01057,R01818,R02060,R08639 RC00002,RC00408 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_3178 Bacteria 2GKTE@201174,4EFSZ@85012,COG1109@1,COG1109@2,COG1208@1,COG1208@2 NA|NA|NA GJM Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III KOPIJCMJ_02813 479433.Caci_3123 1.2e-27 130.6 Actinobacteria GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 Bacteria 2GMS5@201174,COG3879@1,COG3879@2 NA|NA|NA S protein conserved in bacteria KOPIJCMJ_02814 1306174.JODP01000002_gene5961 1.7e-35 155.2 Actinobacteria sbp Bacteria 2IKJW@201174,COG3856@1,COG3856@2 NA|NA|NA S conserved protein (small basic protein) KOPIJCMJ_02815 1385518.N798_07750 1.5e-37 163.3 Intrasporangiaceae GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 Bacteria 2GJ3C@201174,4FEXI@85021,COG3879@1,COG3879@2 NA|NA|NA S Bacterial protein of unknown function (DUF881) KOPIJCMJ_02816 222534.KB893671_gene3398 2.2e-37 161.8 Frankiales gcvH ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 iNJ661.Rv1826 Bacteria 2IKN2@201174,4ESYX@85013,COG0509@1,COG0509@2 NA|NA|NA E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein KOPIJCMJ_02817 570268.ANBB01000003_gene540 1.8e-36 159.1 Streptosporangiales Bacteria 2GK99@201174,4EJ30@85012,COG1716@1,COG1716@2 NA|NA|NA T Inner membrane component of T3SS, cytoplasmic domain KOPIJCMJ_02818 1120950.KB892707_gene5034 8.9e-64 250.4 Propionibacteriales merR1 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 Bacteria 2HBV6@201174,4DQDI@85009,COG0789@1,COG0789@2 NA|NA|NA K helix_turn_helix, mercury resistance KOPIJCMJ_02819 1449346.JQMO01000003_gene3002 2e-40 172.2 Kitasatospora GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 ko:K03617,ko:K08999 ko00000 Bacteria 2GN26@201174,2M26I@2063,COG1259@1,COG1259@2 NA|NA|NA S Bifunctional nuclease KOPIJCMJ_02820 1095767.CAHD01000209_gene127 5e-67 260.8 Cellulomonadaceae merR2 Bacteria 2GM67@201174,4F16V@85016,COG0789@1,COG0789@2 NA|NA|NA K helix_turn_helix, mercury resistance KOPIJCMJ_02821 471852.Tcur_2429 0.0 1225.7 Streptosporangiales gcvP GO:0003674,GO:0003824,GO:0004375,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016638,GO:0016642,GO:0030312,GO:0040007,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944 1.4.4.2 ko:K00281,ko:K00282 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 iECIAI39_1322.ECIAI39_3318 Bacteria 2GJ11@201174,4EI8D@85012,COG0403@1,COG0403@2,COG1003@1,COG1003@2 NA|NA|NA E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor KOPIJCMJ_02822 44060.JODL01000004_gene2457 3.6e-38 164.9 Actinobacteria Bacteria 2IFC7@201174,COG5083@1,COG5083@2 NA|NA|NA S phosphatidylinositol transporter activity KOPIJCMJ_02823 711393.AYRX01000031_gene269 1e-38 166.4 Actinobacteria Bacteria 2IFBJ@201174,COG2050@1,COG2050@2 NA|NA|NA Q Domain of unknown function (DUF4442) KOPIJCMJ_02824 479433.Caci_2340 1.1e-287 995.7 Actinobacteria fusA2 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0030312,GO:0044237,GO:0044464,GO:0071944 ko:K02355 ko00000,ko03012,ko03029 Bacteria 2GKRU@201174,COG0480@1,COG0480@2 NA|NA|NA J elongation factor G KOPIJCMJ_02825 1089455.MOPEL_021_00590 2e-43 182.6 Dermatophilaceae pgsA1 GO:0003674,GO:0003824,GO:0003881,GO:0003882,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.7.8.11,2.7.8.5 ko:K00995,ko:K00999 ko00562,ko00564,ko01100,ko04070,map00562,map00564,map01100,map04070 R01801,R01802 RC00002,RC00017,RC00078,RC02795 ko00000,ko00001,ko01000 Bacteria 2GYKW@201174,4F6UB@85018,COG0558@1,COG0558@2 NA|NA|NA I CDP-alcohol phosphatidyltransferase KOPIJCMJ_02826 566461.SSFG_05851 5.2e-82 311.2 Actinobacteria htrB GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.3.1.241,2.3.1.265 ko:K02517,ko:K22311 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 Bacteria 2GM7B@201174,COG1560@1,COG1560@2 NA|NA|NA M Lipid A biosynthesis KOPIJCMJ_02827 1169161.KB897725_gene1738 1.7e-117 429.5 Actinobacteria pimA GO:0000026,GO:0000030,GO:0000287,GO:0003674,GO:0003824,GO:0004376,GO:0004377,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006644,GO:0006650,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0043167,GO:0043169,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046486,GO:0046488,GO:0046872,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.4.1.345 ko:K08256 R11702 ko00000,ko01000,ko01003 GT4 Bacteria 2GKQ8@201174,COG0438@1,COG0438@2 NA|NA|NA M PFAM Glycosyl transferase, group 1 KOPIJCMJ_02828 1157637.KB892156_gene4020 3.6e-38 164.9 Actinobacteria ko:K03744 ko00000 Bacteria 2GK54@201174,COG1704@1,COG1704@2 NA|NA|NA L nUDIX hydrolase KOPIJCMJ_02829 1120936.KB907223_gene2469 3.4e-58 232.3 Streptosporangiales yerB Bacteria 2GP8D@201174,4EGFU@85012,COG1470@1,COG1470@2 NA|NA|NA S Protein of unknown function (DUF3048) C-terminal domain KOPIJCMJ_02833 93220.LV28_08510 4.5e-210 737.6 Burkholderiaceae recQ GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008270,GO:0009295,GO:0009378,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017116,GO:0017117,GO:0030894,GO:0032392,GO:0032508,GO:0032991,GO:0032993,GO:0033202,GO:0033554,GO:0034641,GO:0042623,GO:0043138,GO:0043140,GO:0043142,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1904949 3.6.4.12 ko:K03654 ko03018,map03018 ko00000,ko00001,ko01000,ko03400 Bacteria 1K353@119060,1MVGG@1224,2VH8W@28216,COG0514@1,COG0514@2 NA|NA|NA L ATP-dependent DNA helicase RecQ KOPIJCMJ_02834 1146883.BLASA_3489 2.2e-134 486.1 Actinobacteria Bacteria 2H3MV@201174,COG0210@1,COG0210@2,COG1112@1,COG1112@2 NA|NA|NA L Type III restriction enzyme res subunit KOPIJCMJ_02835 219305.MCAG_03346 3.2e-24 117.9 Micromonosporales Bacteria 2IMGG@201174,4DF47@85008,COG1846@1,COG1846@2 NA|NA|NA K MarR family KOPIJCMJ_02836 446471.Xcel_1049 1.1e-88 333.2 Promicromonosporaceae nagB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 3.1.1.31,3.5.99.6 ko:K01057,ko:K02564 ko00030,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00520,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R00765,R02035 RC00163,RC00537 ko00000,ko00001,ko00002,ko01000 Bacteria 2GK7F@201174,4F46T@85017,COG0363@1,COG0363@2 NA|NA|NA G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion KOPIJCMJ_02837 1122130.AUHN01000010_gene181 2.6e-68 265.0 Actinobacteria ko:K02315 ko00000,ko03032 Bacteria 2H05C@201174,COG1484@1,COG1484@2 NA|NA|NA L DNA replication protein KOPIJCMJ_02838 861360.AARI_35960 3.5e-148 531.6 Micrococcaceae Bacteria 1W8U7@1268,2GJK7@201174,COG3464@1,COG3464@2 NA|NA|NA L 4.5 Transposon and IS KOPIJCMJ_02839 1112204.GPOL_c26570 2.2e-13 80.9 Actinobacteria 2.1.1.72 ko:K00571,ko:K07316 ko00000,ko01000,ko02048 Bacteria 2I8FH@201174,COG2189@1,COG2189@2 NA|NA|NA L DNA methylase KOPIJCMJ_02840 1120959.ATXF01000009_gene857 6.2e-42 176.4 Microbacteriaceae ko:K07483,ko:K07497 ko00000 Bacteria 2IMG6@201174,4FPFA@85023,COG2963@1,COG2963@2 NA|NA|NA L Transposase KOPIJCMJ_02842 436229.JOEH01000019_gene6552 2.8e-35 154.8 Streptacidiphilus hemE GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_0016 Bacteria 2GMY6@201174,2NH8A@228398,COG0407@1,COG0407@2 NA|NA|NA H Uroporphyrinogen decarboxylase (URO-D) KOPIJCMJ_02843 1380346.JNIH01000057_gene20 7.1e-119 434.5 Actinobacteria hemG 1.3.3.15,1.3.3.4 ko:K00231 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03222,R04178 RC00885 ko00000,ko00001,ko00002,ko01000 Bacteria 2GMMA@201174,COG1232@1,COG1232@2 NA|NA|NA H Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX KOPIJCMJ_02844 585531.HMPREF0063_10544 3e-85 321.6 Propionibacteriales hemH GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 Bacteria 2GK24@201174,4DP69@85009,COG3253@1,COG3253@2 NA|NA|NA S Chlorite dismutase KOPIJCMJ_02845 640132.Srot_1648 1.7e-57 228.8 Actinobacteria msrB 1.8.4.12 ko:K07305 ko00000,ko01000 Bacteria 2IHV0@201174,COG0229@1,COG0229@2 NA|NA|NA O peptide-methionine (R)-S-oxide reductase KOPIJCMJ_02846 1048339.KB913029_gene3893 1.6e-138 499.2 Frankiales Bacteria 2GM0A@201174,4ES0F@85013,COG3285@1,COG3285@2 NA|NA|NA L DNA polymerase LigD KOPIJCMJ_02848 1136417.AZWE01000018_gene977 1.7e-77 296.6 Micromonosporales ligC Bacteria 2I2EA@201174,4DA61@85008,COG1793@1,COG1793@2 NA|NA|NA L DNA ligase KOPIJCMJ_02849 479431.Namu_3543 1.2e-29 136.7 Frankiales ribG 1.1.1.193,3.5.4.26 ko:K00082,ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 Bacteria 2GN2P@201174,4ET37@85013,COG1985@1,COG1985@2 NA|NA|NA H PFAM bifunctional deaminase-reductase domain protein KOPIJCMJ_02850 1449346.JQMO01000002_gene2006 1e-118 433.3 Kitasatospora ko:K06916 ko00000,ko03036 Bacteria 2GNQA@201174,2M1G2@2063,COG1485@1,COG1485@2 NA|NA|NA S AFG1-like ATPase KOPIJCMJ_02851 55952.BU52_14505 1.4e-14 86.3 Actinobacteria Bacteria 2EA6A@1,2II4E@201174,334B4@2 NA|NA|NA S Domain of unknown function (DUF4439) KOPIJCMJ_02852 1449355.JQNR01000005_gene4681 2e-08 65.9 Actinobacteria Bacteria 2EUHF@1,2ISV6@201174,33MZK@2 NA|NA|NA KOPIJCMJ_02853 1245475.ANAE01000075_gene2816 6.1e-40 170.6 Streptosporangiales rimP GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576 ko:K09748 ko00000,ko03009 Bacteria 2I9BT@201174,4EJF1@85012,COG0779@1,COG0779@2 NA|NA|NA S Required for maturation of 30S ribosomal subunits KOPIJCMJ_02854 44060.JODL01000009_gene1920 1.2e-132 479.6 Actinobacteria nusA GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0040007,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 ko:K02600 ko00000,ko03009,ko03021 Bacteria 2GJDJ@201174,COG0195@1,COG0195@2 NA|NA|NA K Participates in both transcription termination and antitermination KOPIJCMJ_02857 1240349.ANGC01000004_gene1728 3.6e-108 398.3 Nocardiaceae alx ko:K05794 ko00000 Bacteria 2GIWU@201174,4FUZ0@85025,COG0861@1,COG0861@2 NA|NA|NA P Integral membrane protein TerC family KOPIJCMJ_02858 1397693.KK211187_gene1704 1e-200 706.4 Bacillales incertae sedis cdr2 Bacteria 1TPWW@1239,3WENZ@539002,4HA11@91061,COG0446@1,COG0446@2,COG0607@1,COG0607@2 NA|NA|NA P Belongs to the sulfur carrier protein TusA family KOPIJCMJ_02859 861299.J421_2256 1.3e-84 319.7 Gemmatimonadetes arsM 2.1.1.137 ko:K07755 ko00000,ko01000 Bacteria 1ZSM8@142182,COG0500@1,COG2226@2 NA|NA|NA Q Hypothetical methyltransferase KOPIJCMJ_02860 446465.Bfae_31180 5.1e-28 130.6 Dermabacteraceae ko:K03892 ko00000,ko03000 Bacteria 2IQDH@201174,4FD6A@85020,COG0640@1,COG0640@2 NA|NA|NA K helix_turn_helix, Arsenical Resistance Operon Repressor KOPIJCMJ_02861 446471.Xcel_3344 2.1e-53 216.1 Promicromonosporaceae 1.20.4.1 ko:K03741,ko:K03892 ko00000,ko01000,ko03000 Bacteria 2IHR3@201174,4F4G0@85017,COG0394@1,COG0394@2,COG0640@1,COG0640@2 NA|NA|NA T Low molecular weight phosphatase family KOPIJCMJ_02862 526225.Gobs_1145 4.7e-48 197.6 Frankiales MA20_23315 Bacteria 2IIUB@201174,4ESS1@85013,COG1765@1,COG1765@2 NA|NA|NA O PFAM OsmC family protein KOPIJCMJ_02863 1463909.KL585957_gene2958 0.0 1080.5 Actinobacteria bgl2 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 GH3 Bacteria 2GJ5H@201174,COG1472@1,COG1472@2 NA|NA|NA G hydrolase, family 3 KOPIJCMJ_02867 479431.Namu_1888 2.5e-17 94.7 Frankiales acyP GO:0003674,GO:0003824,GO:0003998,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016787,GO:0016817,GO:0016818,GO:0050896 3.6.1.7 ko:K01512 ko00620,ko00627,ko01120,map00620,map00627,map01120 R00317,R01421,R01515 RC00043 ko00000,ko00001,ko01000 iSB619.SA_RS07020,iSBO_1134.SBO_2263,iSF_1195.SF0969,iSFxv_1172.SFxv_1053,iS_1188.S1036 Bacteria 2IQ4M@201174,4ETFK@85013,COG1254@1,COG1254@2 NA|NA|NA C Belongs to the acylphosphatase family KOPIJCMJ_02868 1449069.JMLO01000001_gene1725 5.5e-81 307.8 Nocardiaceae fpg GO:0000702,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0008152,GO:0008534,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034039,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 2GJNT@201174,4FV1G@85025,COG0266@1,COG0266@2 NA|NA|NA L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates KOPIJCMJ_02869 561175.KB894094_gene1867 4.8e-75 287.7 Streptosporangiales rnc GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 Bacteria 2GKER@201174,4EGGX@85012,COG0571@1,COG0571@2 NA|NA|NA K Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism KOPIJCMJ_02870 227882.SAV_2666 5.5e-17 92.8 Actinobacteria rpmF GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904 ko:K02911 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011,ko03029 Bacteria 2GQP3@201174,COG0333@1,COG0333@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL32 family KOPIJCMJ_02871 110319.CF8_2880 6.2e-51 207.2 Propionibacteriales yceD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 ko:K07040 ko00000 Bacteria 2GJTS@201174,4DQUU@85009,COG1399@1,COG1399@2 NA|NA|NA S Uncharacterized ACR, COG1399 KOPIJCMJ_02872 1463921.JODF01000032_gene2667 1.8e-16 92.8 Actinobacteria Bacteria 2GNBF@201174,COG0711@1,COG0711@2 NA|NA|NA C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) KOPIJCMJ_02873 882086.SacxiDRAFT_1033 1.1e-59 236.1 Pseudonocardiales coaD GO:0003674,GO:0003824,GO:0004595,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016043,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0022607,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034214,GO:0034641,GO:0034654,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0055086,GO:0065003,GO:0070566,GO:0071704,GO:0071840,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 2GN1S@201174,4E33S@85010,COG0669@1,COG0669@2 NA|NA|NA H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate KOPIJCMJ_02874 1033730.CAHG01000016_gene241 4.3e-42 177.9 Propionibacteriales rsmD GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052913,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.171 ko:K08316 R07234 RC00003 ko00000,ko01000,ko03009 Bacteria 2GQ3G@201174,4DQZ1@85009,COG0742@1,COG0742@2 NA|NA|NA L Conserved hypothetical protein 95 KOPIJCMJ_02875 1123322.KB904683_gene4838 3.9e-224 784.6 Actinobacteria recG GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 ko:K03655 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 2GKA3@201174,COG1200@1,COG1200@2 NA|NA|NA L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) KOPIJCMJ_02876 1123320.KB889676_gene2888 1.1e-109 404.1 Actinobacteria dak3 2.7.1.28,2.7.1.29,4.6.1.15 ko:K00863,ko:K07030 ko00051,ko00561,ko00680,ko01100,ko01120,ko01200,ko04622,map00051,map00561,map00680,map01100,map01120,map01200,map04622 M00344 R01011,R01059 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKII@201174,COG1461@1,COG1461@2 NA|NA|NA S Dihydroxyacetone kinase KOPIJCMJ_02877 446471.Xcel_2281 4.9e-27 126.3 Promicromonosporaceae rpmB GO:0003674,GO:0003735,GO:0005198 ko:K02902 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GQNU@201174,4F4SP@85017,COG0227@1,COG0227@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL28 family KOPIJCMJ_02878 1463887.KL589967_gene6542 3.3e-90 338.6 Actinobacteria thiL GO:0008150,GO:0040007 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv2977c,iYO844.BSU05900 Bacteria 2GP6E@201174,COG0611@1,COG0611@2 NA|NA|NA H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 KOPIJCMJ_02879 471857.Svir_09180 4.8e-24 116.7 Pseudonocardiales Bacteria 2IQ4Z@201174,4E5C4@85010,COG1522@1,COG1522@2 NA|NA|NA K AsnC family KOPIJCMJ_02880 1120950.KB892741_gene2701 2.7e-18 98.6 Propionibacteriales Bacteria 2CQFE@1,2GRVK@201174,32SM3@2,4DS6W@85009 NA|NA|NA S Protein of unknown function (DUF3515) KOPIJCMJ_02881 1229780.BN381_60056 8.1e-31 140.6 Actinobacteria rimJ2 Bacteria 2IS6V@201174,COG1670@1,COG1670@2 NA|NA|NA J Acetyltransferase (GNAT) domain KOPIJCMJ_02882 1120950.KB892707_gene4586 3.7e-212 744.6 Propionibacteriales 3.4.19.1 ko:K01303 ko00000,ko01000,ko01002 Bacteria 2GJW4@201174,4DTZJ@85009,COG1506@1,COG1506@2 NA|NA|NA E Dienelactone hydrolase family KOPIJCMJ_02883 1048339.KB913029_gene3486 1.4e-121 443.0 Frankiales ddl GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008716,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0016874,GO:0016879,GO:0016881,GO:0044424,GO:0044444,GO:0044464,GO:0050896 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 iAF1260.b0381,iB21_1397.B21_00332,iBWG_1329.BWG_0265,iE2348C_1286.E2348C_0317,iEC042_1314.EC042_0413,iEC55989_1330.EC55989_0386,iECBD_1354.ECBD_3283,iECB_1328.ECB_00328,iECDH10B_1368.ECDH10B_0338,iECDH1ME8569_1439.ECDH1ME8569_0367,iECD_1391.ECD_00328,iECH74115_1262.ECH74115_0453,iECIAI1_1343.ECIAI1_0377,iECIAI39_1322.ECIAI39_0301,iECO103_1326.ECO103_0356,iECO111_1330.ECO111_0411,iECO26_1355.ECO26_0414,iECSE_1348.ECSE_0401,iECSP_1301.ECSP_0441,iECs_1301.ECs0431,iETEC_1333.ETEC_0434,iEcDH1_1363.EcDH1_3227,iEcE24377_1341.EcE24377A_0406,iEcHS_1320.EcHS_A0447,iEcSMS35_1347.EcSMS35_0410,iEcolC_1368.EcolC_3251,iJO1366.b0381,iJR904.b0381,iSF_1195.SF0232,iSFxv_1172.SFxv_0245,iS_1188.S0254,iUMNK88_1353.UMNK88_429,iY75_1357.Y75_RS01965,iZ_1308.Z0477 Bacteria 2GITC@201174,4ERWT@85013,COG1181@1,COG1181@2 NA|NA|NA M Belongs to the D-alanine--D-alanine ligase family KOPIJCMJ_02884 1120950.KB892741_gene2699 1e-103 383.6 Propionibacteriales metB 2.5.1.48,4.4.1.8 ko:K01739,ko:K01760 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04941,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00382,RC00420,RC00488,RC00710,RC01245,RC02303,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 Bacteria 2GMD8@201174,4DPBS@85009,COG0626@1,COG0626@2 NA|NA|NA E Cys/Met metabolism PLP-dependent enzyme KOPIJCMJ_02885 397278.JOJN01000003_gene1964 2.1e-46 192.6 Propionibacteriales Bacteria 2I655@201174,4DSYQ@85009,COG3064@1,COG3064@2 NA|NA|NA M Membrane KOPIJCMJ_02886 1288079.AUKN01000001_gene4099 1.2e-116 426.4 Actinobacteria gpsA 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 R00842,R00844 RC00029 ko00000,ko00001,ko01000 Bacteria 2GJSD@201174,COG0240@1,COG0240@2 NA|NA|NA I Glycerol-3-phosphate dehydrogenase KOPIJCMJ_02887 1123320.KB889676_gene2895 4.1e-64 251.5 Actinobacteria plsC2 Bacteria 2GKVA@201174,COG0204@1,COG0204@2 NA|NA|NA I Acyltransferase KOPIJCMJ_02889 1380354.JIAN01000008_gene3362 5.1e-64 252.3 Actinobacteria 3.2.1.91 ko:K19668 ko00500,ko01100,ko02020,map00500,map01100,map02020 R02886,R11308 RC00799 ko00000,ko00001,ko01000 GH6 Bacteria 2GN7G@201174,COG3291@1,COG3291@2,COG3420@1,COG3420@2 NA|NA|NA P PFAM PKD domain containing protein KOPIJCMJ_02890 31964.CMS2390 9.4e-72 277.3 Microbacteriaceae gumI 2.4.1.251 ko:K13658 R09734 RC00005,RC00049 ko00000,ko01000,ko01003 Bacteria 2IAJJ@201174,4FMGW@85023,COG0438@1,COG0438@2 NA|NA|NA M Glycosyl transferases group 1 KOPIJCMJ_02891 1110697.NCAST_19_00740 7.1e-09 65.5 Nocardiaceae 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 Bacteria 2GIRF@201174,4FVQ3@85025,COG2217@1,COG2217@2 NA|NA|NA P Heavy-metal-associated domain KOPIJCMJ_02892 1366050.N234_19840 1.8e-38 165.6 Burkholderiaceae ypeA ko:K03826 ko00000,ko01000 Bacteria 1K7QV@119060,1RA6D@1224,2VSN2@28216,COG0454@1,COG0456@2 NA|NA|NA K PFAM GCN5-related N-acetyltransferase KOPIJCMJ_02893 591167.Sfla_5812 9.3e-37 160.2 Actinobacteria 3.6.1.13 ko:K01515 ko00230,map00230 R01054 RC00002 ko00000,ko00001,ko01000 Bacteria 2GRXY@201174,COG0494@1,COG0494@2 NA|NA|NA L NUDIX domain KOPIJCMJ_02895 1095767.CAHD01000239_gene1882 5.6e-62 244.6 Actinobacteria ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 28JAE@1,2IFSW@201174,2Z957@2 NA|NA|NA KOPIJCMJ_02896 593907.Celgi_2332 7.4e-106 390.6 Cellulomonadaceae ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GJDP@201174,4F0GT@85016,COG1131@1,COG1131@2 NA|NA|NA V PFAM ABC transporter related KOPIJCMJ_02897 397278.JOJN01000003_gene2085 5e-178 630.6 Propionibacteriales desA3 1.14.19.3 ko:K00508 ko00591,ko01100,map00591,map01100 R07063 RC00917 ko00000,ko00001,ko01000,ko01004 Bacteria 2GJKF@201174,4DNPH@85009,COG3239@1,COG3239@2 NA|NA|NA I Fatty acid desaturase KOPIJCMJ_02898 1386089.N865_18720 4.1e-137 494.6 Intrasporangiaceae Bacteria 2GJSW@201174,4FEMH@85021,COG1018@1,COG1018@2 NA|NA|NA C Stearoyl-CoA 9-desaturase KOPIJCMJ_02899 1380347.JNII01000011_gene840 7.1e-106 391.0 Frankiales Bacteria 2GR38@201174,4ESI5@85013,COG2508@1,COG2508@2 NA|NA|NA QT transcriptional regulator, PucR family KOPIJCMJ_02900 479431.Namu_5174 6.4e-166 591.3 Frankiales ko:K06994 ko00000 Bacteria 2GJ5A@201174,4ESAG@85013,COG2409@1,COG2409@2 NA|NA|NA S MMPL family KOPIJCMJ_02901 1122933.JNIY01000003_gene727 1.2e-63 250.8 Cellulomonadaceae ko:K03281 ko00000 2.A.49 Bacteria 2GJHP@201174,4F2KU@85016,COG0038@1,COG0038@2 NA|NA|NA P Voltage gated chloride channel KOPIJCMJ_02902 1499967.BAYZ01000019_gene6314 4.2e-24 117.9 unclassified Bacteria sixA 3.6.1.55 ko:K03574,ko:K08296 ko00000,ko01000,ko03400 Bacteria 2NRKX@2323,COG2062@1,COG2062@2 NA|NA|NA T Histidine phosphatase superfamily (branch 1) KOPIJCMJ_02903 1255043.TVNIR_2461 7.1e-14 83.6 Chromatiales ko:K11312 ko00000 Bacteria 1QUHG@1224,1T1Z6@1236,1WZ1B@135613,COG0662@1,COG0662@2 NA|NA|NA G PFAM Cupin 2, conserved barrel KOPIJCMJ_02904 1120949.KB903335_gene9688 1.9e-32 145.6 Actinobacteria Bacteria 2H6QZ@201174,COG4803@1,COG4803@2 NA|NA|NA S membrane protein of uknown function UCP014873 KOPIJCMJ_02906 1032480.MLP_42530 2.6e-34 152.5 Actinobacteria Bacteria 2I6ZG@201174,COG0639@1,COG0639@2 NA|NA|NA T Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP KOPIJCMJ_02907 1211815.CBYP010000005_gene232 1.1e-16 94.4 Actinobacteria Bacteria 2GVAC@201174,COG1277@1,COG1277@2 NA|NA|NA S ABC-type transport system involved in multi-copper enzyme maturation permease component KOPIJCMJ_02908 1380393.JHVP01000007_gene4343 2e-86 325.9 Actinobacteria ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GN8P@201174,COG1131@1,COG1131@2 NA|NA|NA V ABC transporter KOPIJCMJ_02909 685727.REQ_07710 7.9e-30 137.5 Nocardiaceae Bacteria 2I2JW@201174,4G9F0@85025,COG0500@1,COG2226@2 NA|NA|NA Q Thiopurine S-methyltransferase (TPMT) KOPIJCMJ_02910 469371.Tbis_3425 4e-47 194.1 Pseudonocardiales panD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0016485,GO:0016540,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0051604,GO:0071704,GO:1901564 4.1.1.11 ko:K01579 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R00489 RC00299 ko00000,ko00001,ko00002,ko01000 iECP_1309.ECP_0139,iYL1228.KPN_00139 Bacteria 2IHTC@201174,4E2JG@85010,COG0853@1,COG0853@2 NA|NA|NA H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine KOPIJCMJ_02911 1137268.AZXF01000026_gene2413 1.7e-26 126.3 Streptosporangiales ko:K06950 ko00000 Bacteria 2IAVS@201174,4EJTM@85012,COG1418@1,COG1418@2 NA|NA|NA S PFAM metal-dependent phosphohydrolase, HD sub domain KOPIJCMJ_02912 760011.Spico_1472 2.3e-112 412.1 Spirochaetes metAA GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0008899,GO:0009001,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016750,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.46 ko:K00651 ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230 M00017 R01777 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS11970,iLJ478.TM0881 Bacteria 2J60Z@203691,COG1897@1,COG1897@2 NA|NA|NA E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine KOPIJCMJ_02913 350054.Mflv_0939 5.7e-11 73.2 Mycobacteriaceae Bacteria 23B65@1762,2EK1R@1,2GWKM@201174,33DS7@2 NA|NA|NA S Phospholipase_D-nuclease N-terminal KOPIJCMJ_02914 478741.JAFS01000001_gene1899 1.3e-54 219.9 unclassified Verrucomicrobia fabI GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0034641,GO:0042364,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.10,1.3.1.9 ko:K00208 ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212 M00083,M00572 R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 iECUMN_1333.ECUMN_1592 Bacteria 37G8S@326457,46UJB@74201,COG0623@1,COG0623@2 NA|NA|NA I Enoyl-(Acyl carrier protein) reductase KOPIJCMJ_02915 1304865.JAGF01000001_gene688 1.7e-156 558.9 Actinobacteria Bacteria 28IW2@1,2IA78@201174,2Z8UC@2 NA|NA|NA KOPIJCMJ_02916 1304865.JAGF01000001_gene687 0.0 1289.2 Cellulomonadaceae hppA 3.6.1.1 ko:K15987 ko00190,map00190 ko00000,ko00001,ko01000 3.A.10.1 Bacteria 2GN8B@201174,4F0E3@85016,COG3808@1,COG3808@2 NA|NA|NA C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force KOPIJCMJ_02917 471852.Tcur_3681 1.1e-99 369.8 Streptosporangiales atrC 3.6.3.21 ko:K02028 M00236 ko00000,ko00002,ko01000,ko02000 3.A.1.3 Bacteria 2GIZW@201174,4EHV2@85012,COG1126@1,COG1126@2 NA|NA|NA E ATPases associated with a variety of cellular activities KOPIJCMJ_02918 263358.VAB18032_26240 3.4e-103 381.7 Micromonosporales ko:K02029,ko:K10009 ko02010,map02010 M00234,M00236 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.10,3.A.1.3.14 Bacteria 2GJJ9@201174,4DAHV@85008,COG0765@1,COG0765@2 NA|NA|NA E ABC-type amino acid transport system, permease component KOPIJCMJ_02919 263358.VAB18032_26245 2.7e-86 325.5 Micromonosporales pknD ko:K02030 M00236 ko00000,ko00002,ko02000 3.A.1.3 Bacteria 2GJQW@201174,4DCDW@85008,COG0834@1,COG0834@2 NA|NA|NA ET ABC-type amino acid transport signal transduction systems, periplasmic component domain KOPIJCMJ_02920 1463856.JOHY01000004_gene6505 1.3e-20 107.1 Actinobacteria 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 2GJ6V@201174,COG0204@1,COG0204@2 NA|NA|NA I Acyltransferase KOPIJCMJ_02921 525904.Tter_2417 1.7e-10 72.0 Bacteria ko:K09932 ko00000 Bacteria COG3224@1,COG3224@2 NA|NA|NA KOPIJCMJ_02922 134676.ACPL_4177 3.6e-59 236.1 Actinobacteria Bacteria 2ID0G@201174,COG2199@1,COG3706@2 NA|NA|NA T GGDEF domain KOPIJCMJ_02923 1128421.JAGA01000001_gene2274 2.3e-106 392.1 unclassified Bacteria scrK 2.7.1.2,2.7.1.4 ko:K00845,ko:K00847 ko00010,ko00051,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00051,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R00760,R00867,R01600,R01786,R03920 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 2NQJS@2323,COG1940@1,COG1940@2 NA|NA|NA GK ROK family KOPIJCMJ_02924 1032480.MLP_00540 3.7e-14 85.1 Propionibacteriales hvsT ko:K03321 ko00000,ko02000 2.A.53.3 Bacteria 2GJCB@201174,4DP1B@85009,COG0659@1,COG0659@2,COG4530@1,COG4530@2 NA|NA|NA P Sulfate permease family KOPIJCMJ_02926 1121933.AUHH01000010_gene2519 2.7e-173 614.8 Actinobacteria Bacteria 2IC5F@201174,COG4974@1,COG4974@2 NA|NA|NA L Belongs to the 'phage' integrase family KOPIJCMJ_02928 526226.Gbro_2584 2e-234 818.5 Gordoniaceae ko:K03733,ko:K04763 ko00000,ko03036 Bacteria 2IBD6@201174,4GFSJ@85026,COG4974@1,COG4974@2 NA|NA|NA L PFAM integrase family protein KOPIJCMJ_02929 526226.Gbro_2585 5.7e-138 497.3 Gordoniaceae Bacteria 2I9ZX@201174,4GFWP@85026,COG4974@1,COG4974@2 NA|NA|NA L integrase domain protein SAM domain protein KOPIJCMJ_02930 110319.CF8_4229 2.8e-132 478.4 Actinobacteria ko:K07497 ko00000 Bacteria 2GKDY@201174,COG2801@1,COG2801@2 NA|NA|NA L PFAM Integrase catalytic KOPIJCMJ_02931 1121928.AUHE01000033_gene430 1e-199 702.6 Gordoniaceae insI1 GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004803,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0030983,GO:0032135,GO:0032196,GO:0032991,GO:0032993,GO:0034641,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 ko:K07482 ko00000 Bacteria 2GMZX@201174,4GASI@85026,COG2826@1,COG2826@2 NA|NA|NA L Transposase and inactivated derivatives IS30 family KOPIJCMJ_02932 1169161.KB897713_gene6745 4.1e-17 94.0 Actinobacteria Bacteria 2BUP0@1,2HB4B@201174,32PZX@2 NA|NA|NA KOPIJCMJ_02933 1169161.KB897713_gene6746 1.7e-22 113.2 Actinobacteria Bacteria 2APF8@1,2GVSP@201174,31VJ9@2 NA|NA|NA KOPIJCMJ_02936 1227487.C474_12461 2.8e-165 589.0 Halobacteria treZ 2.4.1.18,3.2.1.141 ko:K00700,ko:K01236 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110,R09995,R11256 RC00049 ko00000,ko00001,ko00002,ko01000,ko04147 CBM48,GH13 Archaea 23ZEB@183963,2Y0XG@28890,COG0296@1,arCOG02951@2157 NA|NA|NA G Alpha amylase, catalytic domain KOPIJCMJ_02937 446466.Cfla_0883 8.1e-22 110.5 Cellulomonadaceae ctc GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02897 ko03010,map03010 M00178 ko00000,ko00001,ko00002,ko03011 Bacteria 2GJPJ@201174,4F160@85016,COG1825@1,COG1825@2 NA|NA|NA J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance KOPIJCMJ_02938 1120950.KB892752_gene6143 6.6e-62 243.8 Propionibacteriales pth GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016787,GO:0016788,GO:0040007,GO:0044464,GO:0052689,GO:0071944,GO:0140098,GO:0140101 3.1.1.29 ko:K01056 ko00000,ko01000,ko03012 Bacteria 2GKCV@201174,4DPFB@85009,COG0193@1,COG0193@2 NA|NA|NA J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis KOPIJCMJ_02939 350058.Mvan_3479 6.1e-42 177.9 Mycobacteriaceae cysQ GO:0000103,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008441,GO:0008934,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016020,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019637,GO:0019693,GO:0030145,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042132,GO:0042578,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050308,GO:0050427,GO:0050897,GO:0052745,GO:0052834,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564 3.1.3.7 ko:K01082 ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130 R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03016 Bacteria 232H4@1762,2GMW7@201174,COG1218@1,COG1218@2 NA|NA|NA P Inositol monophosphatase KOPIJCMJ_02942 1184609.KILIM_042_00100 1.4e-155 555.8 Actinobacteria nifJ 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2I995@201174,COG0674@1,COG0674@2,COG1013@1,COG1013@2,COG1014@1,COG1014@2,COG1144@1,COG1144@2,COG1145@1,COG1145@2 NA|NA|NA C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin KOPIJCMJ_02944 1305732.JAGG01000001_gene778 3.5e-16 91.3 Microbacteriaceae yidH ko:K00389 ko00000 Bacteria 2GQU9@201174,4FQ80@85023,COG2149@1,COG2149@2 NA|NA|NA S Domain of unknown function (DUF202) KOPIJCMJ_02945 1380354.JIAN01000009_gene3760 6.4e-76 292.7 Actinobacteria Bacteria 2I8YV@201174,COG1652@1,COG1652@2 NA|NA|NA NU PFAM Peptidoglycan-binding LysM KOPIJCMJ_02946 1380356.JNIK01000001_gene2282 2.5e-21 108.6 Frankiales Bacteria 2E4ST@1,2GSCH@201174,32ZM5@2,4ETEF@85013 NA|NA|NA KOPIJCMJ_02947 1463853.JOHW01000040_gene6696 8.1e-22 110.2 Actinobacteria Bacteria 2GRCJ@201174,COG4961@1,COG4961@2 NA|NA|NA U PFAM TadE family protein KOPIJCMJ_02948 1380354.JIAN01000009_gene3757 5.9e-19 100.5 Bacteria Bacteria COG4961@1,COG4961@2 NA|NA|NA U PFAM TadE family protein KOPIJCMJ_02950 1380354.JIAN01000009_gene3755 1e-50 207.2 Actinobacteria ko:K12510 ko00000,ko02044 Bacteria 2I2Z3@201174,COG4965@1,COG4965@2 NA|NA|NA U type II secretion system KOPIJCMJ_02951 1380354.JIAN01000009_gene3754 6.5e-50 204.5 Actinobacteria Bacteria 2GN6E@201174,COG4965@1,COG4965@2 NA|NA|NA U type II secretion system KOPIJCMJ_02952 1380354.JIAN01000009_gene3753 6.2e-133 480.7 Cellulomonadaceae ko:K02283 ko00000,ko02035,ko02044 Bacteria 2GKKJ@201174,4F10A@85016,COG4962@1,COG4962@2 NA|NA|NA U Type II/IV secretion system protein KOPIJCMJ_02953 1449353.JQMQ01000005_gene5167 2.3e-25 122.9 Streptacidiphilus Bacteria 2HT5K@201174,2NF4C@228398,COG0455@1,COG0455@2 NA|NA|NA D bacterial-type flagellum organization KOPIJCMJ_02954 1137268.AZXF01000033_gene3440 7.6e-26 124.4 Streptosporangiales Bacteria 2I6YM@201174,4ER8Y@85012,COG1261@1,COG1261@2 NA|NA|NA NO Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly KOPIJCMJ_02955 1048339.KB913029_gene479 1.9e-27 129.8 Actinobacteria Bacteria 2F8QI@1,2H6TB@201174,3412U@2 NA|NA|NA KOPIJCMJ_02957 1246445.ANAY01000013_gene117 3.8e-38 165.6 Streptosporangiales ykrP ko:K13663 ko00000,ko01000 Bacteria 2GJXP@201174,4EHTM@85012,COG3594@1,COG3594@2 NA|NA|NA G Acyltransferase family KOPIJCMJ_02958 203119.Cthe_0110 6.1e-79 301.2 Ruminococcaceae hprK GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 ko:K06023 ko00000,ko01000 Bacteria 1TP5Z@1239,24999@186801,3WGB3@541000,COG1493@1,COG1493@2 NA|NA|NA H Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion KOPIJCMJ_02959 1150399.AQYK01000001_gene1558 5.5e-42 177.9 Microbacteriaceae iphP 3.1.3.48,3.1.4.53 ko:K01104,ko:K03651 ko00230,ko02025,map00230,map02025 R00191 RC00296 ko00000,ko00001,ko01000 Bacteria 2GK28@201174,4FN9A@85023,COG2365@1,COG2365@2 NA|NA|NA T Tyrosine phosphatase family KOPIJCMJ_02960 1291050.JAGE01000001_gene2582 2e-68 266.2 Ruminococcaceae hprK GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 ko:K06023 ko00000,ko01000 Bacteria 1TP5Z@1239,24999@186801,3WGB3@541000,COG1493@1,COG1493@2 NA|NA|NA H Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion KOPIJCMJ_02961 1193181.BN10_1190010 4.9e-62 245.4 Intrasporangiaceae pepA ko:K08372 ko02020,map02020 ko00000,ko00001,ko01000,ko01002 Bacteria 2GJJ3@201174,4FJ5Z@85021,COG0265@1,COG0265@2 NA|NA|NA O Domain present in PSD-95, Dlg, and ZO-1/2. KOPIJCMJ_02962 1229780.BN381_210036 9.7e-77 293.5 Actinobacteria Bacteria 2GJSF@201174,COG0500@1,COG2226@2 NA|NA|NA Q methyltransferase KOPIJCMJ_02963 2002.JOEQ01000004_gene2898 5.6e-160 571.2 Streptosporangiales ko:K07114 ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 Bacteria 2GNSN@201174,4EH2B@85012,COG1840@1,COG1840@2,COG2304@1,COG2304@2 NA|NA|NA P von Willebrand factor type A domain KOPIJCMJ_02964 35754.JNYJ01000005_gene5499 3.8e-09 68.9 Micromonosporales Bacteria 2FIZ9@1,2INWA@201174,34AQ2@2,4DIXT@85008 NA|NA|NA KOPIJCMJ_02965 909613.UO65_3424 3.7e-58 231.5 Pseudonocardiales ko:K09019 ko00240,ko01100,map00240,map01100 R09289 RC00087 ko00000,ko00001,ko01000 Bacteria 2HC1J@201174,4DZB0@85010,COG0778@1,COG0778@2 NA|NA|NA C Nitroreductase family KOPIJCMJ_02966 1003195.SCAT_1757 1.5e-227 796.2 Actinobacteria pepN 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 Bacteria 2GJJ4@201174,COG0308@1,COG0308@2 NA|NA|NA E aminopeptidase N KOPIJCMJ_02967 590998.Celf_3362 4.2e-42 178.3 Cellulomonadaceae litS ko:K03088 ko00000,ko03021 Bacteria 2IKQ7@201174,4F2I1@85016,COG1595@1,COG1595@2 NA|NA|NA K TIGRFAM RNA polymerase sigma factor, sigma-70 family KOPIJCMJ_02968 590998.Celf_3363 5.3e-35 154.8 Cellulomonadaceae Bacteria 2IM7X@201174,4F2HP@85016,COG5343@1,COG5343@2 NA|NA|NA S Anti-sigma-K factor rskA KOPIJCMJ_02969 1385520.N802_03820 1.1e-52 213.4 Intrasporangiaceae ko:K19519 ko00000,ko04516 Bacteria 2IHKV@201174,4FGQK@85021,COG2335@1,COG2335@2 NA|NA|NA M Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. KOPIJCMJ_02970 1121899.Q764_09130 2.4e-22 111.3 Flavobacterium Bacteria 1I3HF@117743,2NX4C@237,4NSVZ@976,COG2314@1,COG2314@2 NA|NA|NA S Pfam TM2 domain KOPIJCMJ_02972 446471.Xcel_1960 1.3e-09 68.9 Actinobacteria ko:K06907 ko00000 Bacteria 2GMJA@201174,COG3497@1,COG3497@2 NA|NA|NA S tail sheath protein KOPIJCMJ_02973 446471.Xcel_1959 9e-56 223.0 Actinobacteria Bacteria 2DB76@1,2GKK0@201174,2Z7JZ@2 NA|NA|NA S T4-like virus tail tube protein gp19 KOPIJCMJ_02974 446471.Xcel_1958 7e-180 637.5 Actinobacteria ko:K06907 ko00000 Bacteria 2IG6A@201174,COG3497@1,COG3497@2 NA|NA|NA S Phage tail sheath protein subtilisin-like domain KOPIJCMJ_02975 379066.GAU_3439 2e-36 159.1 Bacteria Bacteria 2DMQT@1,32T2H@2 NA|NA|NA S T4-like virus tail tube protein gp19 KOPIJCMJ_02977 446471.Xcel_1955 2e-73 282.3 Actinobacteria Bacteria 2IAAU@201174,COG1652@1,COG1652@2 NA|NA|NA S PFAM Peptidoglycan-binding KOPIJCMJ_02978 446471.Xcel_1954 7.5e-137 493.8 Bacteria ko:K06905 ko00000 Bacteria COG3500@1,COG3500@2 NA|NA|NA KOPIJCMJ_02979 446471.Xcel_1953 2.2e-39 169.5 Actinobacteria Bacteria 2GP13@201174,COG3501@1,COG3501@2 NA|NA|NA S Rhs element Vgr protein KOPIJCMJ_02981 446471.Xcel_1951 6.4e-45 186.8 Actinobacteria ko:K06903 ko00000 Bacteria 2IFJ6@201174,COG3628@1,COG3628@2 NA|NA|NA S GPW gp25 family protein KOPIJCMJ_02982 446471.Xcel_1950 1.4e-217 762.7 Actinobacteria Bacteria 2GM5C@201174,COG3299@1,COG3299@2 NA|NA|NA S Baseplate J-like protein KOPIJCMJ_02983 446471.Xcel_1949 1.5e-148 533.5 Actinobacteria Bacteria 2I52J@201174,COG3391@1,COG3391@2 NA|NA|NA S Phage tail protein (Tail_P2_I) KOPIJCMJ_02984 446471.Xcel_1948 9.4e-65 255.4 Actinobacteria ko:K02040,ko:K20276,ko:K21449 ko02010,ko02020,ko02024,ko05152,map02010,map02020,map02024,map05152 M00222 ko00000,ko00001,ko00002,ko02000 1.B.40.2,3.A.1.7 Bacteria 2IRA0@201174,COG4223@1,COG4223@2 NA|NA|NA M COG3209 Rhs family protein KOPIJCMJ_02985 446471.Xcel_1947 6.7e-116 424.9 Actinobacteria Bacteria 28Q0Z@1,2IAZ4@201174,2ZCJM@2 NA|NA|NA KOPIJCMJ_02986 446471.Xcel_1946 1.3e-135 490.3 Actinobacteria Bacteria 2ERBG@1,2GPQE@201174,33IX4@2 NA|NA|NA KOPIJCMJ_02989 446471.Xcel_1943 5.3e-101 375.6 Actinobacteria Bacteria 2I8CR@201174,COG0464@1,COG0464@2 NA|NA|NA O PFAM AAA ATPase central domain protein KOPIJCMJ_02992 1120950.KB892707_gene4856 1.3e-13 82.0 Propionibacteriales ltaA 4.1.2.48 ko:K01620 ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 R00751,R06171 RC00312,RC00372 ko00000,ko00001,ko01000 Bacteria 2GMNV@201174,4DPQR@85009,COG2008@1,COG2008@2 NA|NA|NA E Beta-eliminating lyase KOPIJCMJ_02993 479433.Caci_6006 1.8e-68 266.2 Actinobacteria ydeD Bacteria 2I8X5@201174,COG0697@1,COG0697@2 NA|NA|NA EG of the drug metabolite transporter (DMT) superfamily KOPIJCMJ_02994 397278.JOJN01000001_gene2592 1.5e-132 480.3 Propionibacteriales pknL 2.7.11.1 ko:K12132 ko00000,ko01000,ko01001 Bacteria 2GJ1J@201174,4DPC3@85009,COG0515@1,COG0515@2,COG2815@1,COG2815@2 NA|NA|NA KLT serine threonine protein kinase KOPIJCMJ_02996 1122609.AUGT01000002_gene3995 1.5e-175 622.5 Propionibacteriales pyrC GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ0T@201174,4DMZJ@85009,COG0044@1,COG0044@2 NA|NA|NA F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily KOPIJCMJ_02997 443255.SCLAV_0714 2.4e-29 135.6 Actinobacteria Bacteria 2GM9I@201174,COG0505@1,COG0505@2 NA|NA|NA EF Belongs to the CarA family KOPIJCMJ_02998 1155718.KB891896_gene2090 2.2e-157 562.0 Actinobacteria carA GO:0000050,GO:0003674,GO:0003824,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0032991,GO:0034641,GO:0034654,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01955,ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 iAPECO1_1312.APECO1_1950,iUTI89_1310.UTI89_C0036,iYO844.BSU15510,ic_1306.c0040 Bacteria 2GKFA@201174,COG0505@1,COG0505@2 NA|NA|NA F Belongs to the CarA family KOPIJCMJ_02999 1996.JOFO01000043_gene6393 7.7e-23 114.8 Actinobacteria Bacteria 2GN14@201174,COG2267@1,COG2267@2 NA|NA|NA I Alpha/beta hydrolase family KOPIJCMJ_03003 1089455.MOPEL_080_00430 4.4e-178 630.9 Dermatophilaceae Bacteria 2GIZP@201174,4F7M0@85018,COG4770@1,COG4770@2,COG4799@1,COG4799@2 NA|NA|NA I Acetyl-CoA carboxylase, central region KOPIJCMJ_03004 234267.Acid_3076 9.8e-26 124.0 Acidobacteria 2.7.8.7 ko:K00997,ko:K06133 ko00770,map00770 R01625 RC00002 ko00000,ko00001,ko01000 Bacteria 3Y8HB@57723,COG2091@1,COG2091@2 NA|NA|NA H 4'-phosphopantetheinyl transferase superfamily KOPIJCMJ_03005 889378.Spiaf_2269 8e-149 533.9 Bacteria amyA GO:0003674,GO:0003824,GO:0004553,GO:0004556,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016160,GO:0016787,GO:0016798,GO:0044424,GO:0044464 3.2.1.1 ko:K01176 ko00500,ko01100,ko04973,map00500,map01100,map04973 R02108,R02112,R11262 ko00000,ko00001,ko01000 GH13 iECH74115_1262.ECH74115_2702,iECSP_1301.ECSP_2532,iECs_1301.ECs2666,iG2583_1286.G2583_2378,iSF_1195.SF1970 Bacteria COG0366@1,COG0366@2 NA|NA|NA G hydrolase activity, hydrolyzing O-glycosyl compounds KOPIJCMJ_03006 284031.JNXD01000007_gene3230 5.4e-70 271.2 Actinobacteria Bacteria 2GJBJ@201174,COG1609@1,COG1609@2 NA|NA|NA K lacI family KOPIJCMJ_03007 749414.SBI_08696 1.4e-69 269.6 Actinobacteria 3.2.1.10,3.2.1.20,3.2.1.93 ko:K01182,ko:K01187,ko:K01226 ko00052,ko00500,ko01100,map00052,map00500,map01100 R00028,R00801,R00802,R00837,R01718,R01791,R06087,R06088,R06113,R06199 RC00028,RC00049,RC00059,RC00077,RC00451 ko00000,ko00001,ko01000 GH13,GH31 Bacteria 2GKS4@201174,COG0366@1,COG0366@2 NA|NA|NA G alpha amylase, catalytic KOPIJCMJ_03008 35754.JNYJ01000043_gene4398 3.9e-20 106.3 Micromonosporales Bacteria 2GKG3@201174,4DDUZ@85008,COG2208@1,COG2208@2 NA|NA|NA KT Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) KOPIJCMJ_03010 28444.JODQ01000001_gene1881 1.2e-150 539.7 Streptosporangiales chrA ko:K07240 ko00000,ko02000 2.A.51.1 Bacteria 2IB69@201174,4EK6V@85012,COG2059@1,COG2059@2 NA|NA|NA P Chromate transporter KOPIJCMJ_03011 1032480.MLP_13020 3.6e-43 181.4 Propionibacteriales Bacteria 2GNA1@201174,4DRXP@85009,COG1695@1,COG1695@2 NA|NA|NA K Transcriptional regulator PadR-like family KOPIJCMJ_03012 1125971.ASJB01000080_gene7628 6.2e-65 254.2 Pseudonocardiales lolD ko:K02003 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GM25@201174,4DXIQ@85010,COG1136@1,COG1136@2 NA|NA|NA V ABC-type antimicrobial peptide transport system, ATPase component KOPIJCMJ_03013 1033730.CAHG01000016_gene217 4.4e-32 146.0 Propionibacteriales Bacteria 2HZH5@201174,4DSSV@85009,COG0577@1,COG0577@2 NA|NA|NA V efflux transmembrane transporter activity KOPIJCMJ_03014 1449069.JMLO01000001_gene1935 9.2e-105 386.3 Nocardiaceae Bacteria 2GMUG@201174,4FZ08@85025,COG2197@1,COG2197@2 NA|NA|NA T cheY-homologous receiver domain KOPIJCMJ_03015 1449069.JMLO01000001_gene1936 1.6e-165 589.0 Nocardiaceae Bacteria 2GS7K@201174,4G082@85025,COG4585@1,COG4585@2 NA|NA|NA T Histidine kinase KOPIJCMJ_03016 469383.Cwoe_0678 2.4e-57 228.4 Rubrobacteria Bacteria 2ICAF@201174,313GU@2,4CQYQ@84995,arCOG06733@1 NA|NA|NA KOPIJCMJ_03017 1306174.JODP01000001_gene4819 5.2e-20 105.9 Bacteria Bacteria COG5555@1,COG5555@2 NA|NA|NA KOPIJCMJ_03018 105420.BBPO01000020_gene5614 4.4e-217 760.8 Streptacidiphilus 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 Bacteria 2IA3D@201174,2NI27@228398,COG3119@1,COG3119@2 NA|NA|NA P Sulfatase KOPIJCMJ_03019 479431.Namu_5044 4e-26 125.6 Frankiales Bacteria 2HF67@201174,4EWG3@85013,COG0477@1,COG2814@2 NA|NA|NA EGP Transmembrane secretion effector KOPIJCMJ_03020 397278.JOJN01000017_gene2520 4.3e-22 111.3 Propionibacteriales Bacteria 2EBIV@1,2IHZS@201174,335JA@2,4DRF2@85009 NA|NA|NA KOPIJCMJ_03021 1122994.AUFR01000024_gene25 4.9e-146 524.6 Propionibacteriales yuaG ko:K07192 ko04910,map04910 ko00000,ko00001,ko03036,ko04131,ko04147 Bacteria 2GK9I@201174,4DNKB@85009,COG2268@1,COG2268@2 NA|NA|NA S Flotillin KOPIJCMJ_03022 2045.KR76_08315 7e-37 161.4 Propionibacteriales ko:K13573 ko00000,ko03051 Bacteria 2IMC4@201174,4DRG9@85009,COG2378@1,COG2378@2 NA|NA|NA K WYL domain KOPIJCMJ_03023 2045.KR76_08310 3.1e-26 125.9 Propionibacteriales Bacteria 2FJ4K@1,2GVYD@201174,34AUV@2,4DS69@85009 NA|NA|NA S WYL domain KOPIJCMJ_03024 33876.JNXY01000028_gene3328 6.2e-07 62.4 Micromonosporales Bacteria 2BNCX@1,2H4ZP@201174,32H0K@2,4DIXP@85008 NA|NA|NA KOPIJCMJ_03026 1394178.AWOO02000082_gene2172 1.8e-18 101.7 Streptosporangiales Bacteria 2GJAR@201174,4EG63@85012,COG2909@1,COG2909@2 NA|NA|NA K AAA ATPase domain KOPIJCMJ_03027 1246995.AFR_19415 6.2e-33 146.7 Micromonosporales ko:K10947 ko00000,ko03000 Bacteria 2IQ51@201174,4DFEK@85008,COG1695@1,COG1695@2 NA|NA|NA K Transcriptional regulator PadR-like family KOPIJCMJ_03028 356851.JOAN01000007_gene4066 3.5e-41 175.6 Micromonosporales 1.3.1.84,4.2.1.116,6.2.1.36 ko:K14469 ko00720,ko01120,ko01200,map00720,map01120,map01200 M00376 R00919,R03045,R09286 RC00004,RC00014,RC00095,RC00834 ko00000,ko00001,ko00002,ko01000 Bacteria 2I8SZ@201174,4DFFZ@85008,COG0604@1,COG0604@2 NA|NA|NA C alcohol dehydrogenase KOPIJCMJ_03029 1035308.AQYY01000001_gene3456 2.6e-58 232.6 Clostridia Bacteria 1UZ78@1239,24BM7@186801,COG3965@1,COG3965@2 NA|NA|NA P cation diffusion facilitator family transporter KOPIJCMJ_03030 1298863.AUEP01000001_gene1052 5.8e-97 361.3 Propionibacteriales ko:K06158 ko00000,ko03012 Bacteria 2GK9S@201174,4DPTY@85009,COG0488@1,COG0488@2 NA|NA|NA S ATPases associated with a variety of cellular activities KOPIJCMJ_03032 378806.STAUR_7361 8.5e-77 293.9 Proteobacteria Bacteria 1NHID@1224,2E4RD@1,302H1@2 NA|NA|NA KOPIJCMJ_03033 649831.L083_3893 2.4e-106 392.9 Micromonosporales gba 3.2.1.45 ko:K01201 ko00511,ko00600,ko01100,ko04142,map00511,map00600,map01100,map04142 R01498 RC00059,RC00451 ko00000,ko00001,ko01000 GH30 Bacteria 2GMWN@201174,4D9UI@85008,COG5520@1,COG5520@2 NA|NA|NA G Glycosyl hydrolase family 30 beta sandwich domain KOPIJCMJ_03035 309807.SRU_2721 9.4e-12 76.6 Bacteroidetes Bacteria 4NHVF@976,COG1680@1,COG1680@2 NA|NA|NA V COG1680 Beta-lactamase class C and other penicillin binding KOPIJCMJ_03036 1032480.MLP_51570 6.1e-101 374.0 Propionibacteriales ko:K07243 ko00000,ko02000 2.A.108.1,2.A.108.2 Bacteria 2GJ22@201174,4DPYF@85009,COG0672@1,COG0672@2 NA|NA|NA P Iron permease FTR1 family KOPIJCMJ_03037 633149.Bresu_2234 7.2e-65 254.2 Caulobacterales MA20_05625 Bacteria 1MU9Y@1224,2KF3K@204458,2TUH0@28211,COG0647@1,COG0647@2 NA|NA|NA G Hydrolase KOPIJCMJ_03038 44060.JODL01000002_gene2206 1.2e-211 742.7 Actinobacteria purH GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 iHN637.CLJU_RS04230,iJN678.purH Bacteria 2GJWU@201174,COG0138@1,COG0138@2 NA|NA|NA F Bifunctional purine biosynthesis protein PurH KOPIJCMJ_03039 43354.JOIJ01000010_gene2460 3.3e-64 251.5 Pseudonocardiales purN GO:0000287,GO:0003674,GO:0005488,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019752,GO:0034641,GO:0042558,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0046483,GO:0046653,GO:0046872,GO:0051186,GO:0071704,GO:1901360,GO:1901564 2.1.2.2,2.1.2.3,3.5.4.10 ko:K00602,ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04325,R04326,R04560 RC00026,RC00197,RC00263,RC00456,RC01128 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2H8QB@201174,4DY8H@85010,COG0299@1,COG0299@2 NA|NA|NA F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate KOPIJCMJ_03040 1120917.AQXM01000038_gene1996 1.9e-16 93.6 Micrococcaceae Bacteria 1W7EP@1268,2I39E@201174,COG3266@1,COG3266@2 NA|NA|NA S domain, Protein KOPIJCMJ_03041 926569.ANT_00100 6.7e-55 220.7 Chloroflexi sdpI Bacteria 2G714@200795,COG5658@1,COG5658@2 NA|NA|NA S SdpI/YhfL protein family KOPIJCMJ_03043 1193181.BN10_900020 3e-11 73.9 Intrasporangiaceae fieF Bacteria 2GJ8Q@201174,4FE8E@85021,COG0053@1,COG0053@2 NA|NA|NA P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family KOPIJCMJ_03044 1122138.AQUZ01000033_gene3629 1.6e-83 316.6 Propionibacteriales lppS GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016787,GO:0017171,GO:0018104,GO:0019538,GO:0030203,GO:0030312,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044464,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 Bacteria 2GJBA@201174,4DN7Y@85009,COG1376@1,COG1376@2 NA|NA|NA S L,D-transpeptidase catalytic domain KOPIJCMJ_03045 1232410.KI421412_gene16 3.6e-269 934.5 Desulfuromonadales 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 Bacteria 1N38V@1224,2WKAZ@28221,42MWC@68525,43SUV@69541,COG0574@1,COG0574@2 NA|NA|NA G Pyruvate phosphate dikinase, PEP/pyruvate binding domain KOPIJCMJ_03046 1095769.CAHF01000025_gene693 1.6e-204 718.8 Oxalobacteraceae gdhA GO:0003674,GO:0003824,GO:0004353,GO:0004354,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.3,1.4.1.4 ko:K00261,ko:K00262 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1MUMF@1224,2VIZ7@28216,472NR@75682,COG0334@1,COG0334@2 NA|NA|NA E Glutamate/Leucine/Phenylalanine/Valine dehydrogenase KOPIJCMJ_03048 710696.Intca_1164 3.4e-65 255.4 Bacteria Bacteria COG0583@1,COG0583@2 NA|NA|NA K DNA-binding transcription factor activity KOPIJCMJ_03049 710696.Intca_1165 6.4e-112 410.6 Intrasporangiaceae psuG GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0019200,GO:0044237,GO:0044238,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046835,GO:0071704 4.2.1.70 ko:K16329 ko00240,map00240 R01055 RC00432,RC00433 ko00000,ko00001,ko01000 Bacteria 2GK19@201174,4FEJH@85021,COG2313@1,COG2313@2 NA|NA|NA Q Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway KOPIJCMJ_03050 1120959.ATXF01000011_gene239 2.4e-11 76.3 Microbacteriaceae 3.1.3.48 ko:K01104 ko00000,ko01000 Bacteria 2GMPR@201174,4FPK5@85023,COG0394@1,COG0394@2 NA|NA|NA T Low molecular weight phosphatase family KOPIJCMJ_03051 500153.JOEK01000002_gene442 4e-23 114.4 Actinobacteria rshA 2.7.11.1 ko:K04757 ko00000,ko01000,ko01001,ko03021 Bacteria 2IFG9@201174,COG2172@1,COG2172@2 NA|NA|NA T anti-sigma regulatory factor KOPIJCMJ_03052 222534.KB893670_gene3630 8.7e-90 337.4 Frankiales sigB GO:0000988,GO:0000990,GO:0003674,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0043620,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141 ko:K03090 ko00000,ko03021 Bacteria 2GKSY@201174,4ES7X@85013,COG1191@1,COG1191@2 NA|NA|NA K RNA polymerase KOPIJCMJ_03054 1123320.KB889737_gene5367 3.8e-71 275.4 Actinobacteria Bacteria 2GJ3K@201174,COG1597@1,COG1597@2 NA|NA|NA I Diacylglycerol kinase KOPIJCMJ_03055 1283283.ATXA01000002_gene2799 5.9e-36 156.4 Frankiales whiB GO:0000302,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0015035,GO:0015036,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042221,GO:0042493,GO:0045892,GO:0045934,GO:0047134,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0060255,GO:0065007,GO:0071731,GO:0080090,GO:0097159,GO:0097366,GO:1901363,GO:1901698,GO:1901700,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 ko:K18955 ko00000,ko03000 Bacteria 2DMIE@1,2IQCG@201174,32RSG@2,4ET35@85013 NA|NA|NA K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA KOPIJCMJ_03056 28444.JODQ01000015_gene1617 2.3e-100 372.9 Streptosporangiales pdtaS GO:0000155,GO:0000160,GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005524,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0017076,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 2.7.13.3 ko:K00936 M00839 ko00000,ko00002,ko01000,ko01001,ko02022 Bacteria 2GKMP@201174,4EG9F@85012,COG3920@1,COG3920@2 NA|NA|NA T Histidine kinase KOPIJCMJ_03057 1123320.KB889733_gene6240 4e-102 378.3 Actinobacteria 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 Bacteria 2GP4W@201174,COG0449@1,COG0449@2 NA|NA|NA M PFAM Sugar isomerase (SIS) KOPIJCMJ_03058 68194.JNXR01000016_gene7360 9.4e-20 103.2 Actinobacteria Bacteria 2IKZP@201174,COG5496@1,COG5496@2 NA|NA|NA S Thioesterase KOPIJCMJ_03059 351607.Acel_0550 1.1e-158 566.2 Frankiales pilT ko:K02669 ko00000,ko02035,ko02044 3.A.15.2 Bacteria 2HPWY@201174,4EUA1@85013,COG2805@1,COG2805@2 NA|NA|NA NU Type II/IV secretion system protein KOPIJCMJ_03060 1385518.N798_03110 2e-23 115.5 Intrasporangiaceae Bacteria 2DRYE@1,2IS24@201174,33DPC@2,4FHPE@85021 NA|NA|NA KOPIJCMJ_03061 1192034.CAP_5004 4.7e-23 114.4 Myxococcales Bacteria 1NBEP@1224,2E4IQ@1,2WW82@28221,2YVWC@29,32ZDS@2,431T4@68525 NA|NA|NA KOPIJCMJ_03062 351607.Acel_0539 6.4e-18 96.7 Frankiales rsrA GO:0000988,GO:0000989,GO:0003674,GO:0005488,GO:0006950,GO:0006979,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009593,GO:0009628,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032502,GO:0042221,GO:0043167,GO:0043169,GO:0043934,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051606,GO:0051775,GO:0051776,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141 Bacteria 2IM2X@201174,4ETFE@85013,COG5662@1,COG5662@2 NA|NA|NA K anti-sigma factor KOPIJCMJ_03063 446471.Xcel_2492 3.3e-81 308.1 Promicromonosporaceae sigH GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141 ko:K03088 ko00000,ko03021 Bacteria 2GJ02@201174,4F3JN@85017,COG1595@1,COG1595@2 NA|NA|NA K Sigma-70, region 4 KOPIJCMJ_03066 1380346.JNIH01000001_gene4275 5.8e-41 174.5 Actinobacteria ko:K07020 ko00000 Bacteria 2GKKE@201174,COG3571@1,COG3571@2 NA|NA|NA S Hydrolase of the alpha beta-hydrolase KOPIJCMJ_03067 469371.Tbis_2926 1.8e-66 259.2 Pseudonocardiales Bacteria 2GKY8@201174,4E13E@85010,COG2135@1,COG2135@2 NA|NA|NA S Belongs to the SOS response-associated peptidase family KOPIJCMJ_03068 1429046.RR21198_0802 2.9e-142 511.9 Nocardiaceae aroA GO:0003674,GO:0003824,GO:0003866,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:0071944,GO:1901576 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJKX@201174,4FU48@85025,COG0128@1,COG0128@2 NA|NA|NA E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate KOPIJCMJ_03069 1385518.N798_08960 9.8e-106 390.2 Intrasporangiaceae rsgA 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 Bacteria 2GJ37@201174,4FEQ3@85021,COG1162@1,COG1162@2 NA|NA|NA S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit KOPIJCMJ_03072 1229780.BN381_830001 9.8e-205 719.5 Actinobacteria Bacteria 2H68X@201174,COG3385@1,COG3385@2 NA|NA|NA L Transposase KOPIJCMJ_03073 1504319.GM45_6205 6e-285 986.5 unclassified Actinobacteria (class) gyrB GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 5.99.1.3 ko:K02470 ko00000,ko01000,ko03032,ko03400 Bacteria 2GKGP@201174,3UW89@52018,COG0187@1,COG0187@2 NA|NA|NA L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner KOPIJCMJ_03074 426716.JOAJ01000009_gene5889 2.4e-29 135.6 Nocardiaceae Bacteria 2GNQ4@201174,4FUXM@85025,COG5512@1,COG5512@2 NA|NA|NA S Belongs to the UPF0232 family KOPIJCMJ_03075 436229.JOEH01000010_gene5297 1.6e-112 412.9 Streptacidiphilus recF GO:0000731,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0018130,GO:0019438,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901576 ko:K03629,ko:K07459 ko03440,map03440 ko00000,ko00001,ko03400 Bacteria 2GJCS@201174,2NGB8@228398,COG1195@1,COG1195@2 NA|NA|NA L AAA domain KOPIJCMJ_03076 1123322.KB904669_gene3635 1.4e-113 416.4 Actinobacteria dnaN GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 2GJK3@201174,COG0592@1,COG0592@2 NA|NA|NA L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria KOPIJCMJ_03077 1504319.GM45_6225 4.2e-171 607.8 unclassified Actinobacteria (class) dnaA GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006172,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009133,GO:0009135,GO:0009136,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009179,GO:0009180,GO:0009185,GO:0009188,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016311,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046031,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990837 ko:K02313 ko02020,ko04112,map02020,map04112 ko00000,ko00001,ko03032,ko03036 Bacteria 2GJKI@201174,3UW7I@52018,COG0593@1,COG0593@2 NA|NA|NA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids KOPIJCMJ_03078 1463820.JOGW01000006_gene6872 3.5e-11 73.2 Actinobacteria rpmH GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02914 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GQFY@201174,COG0230@1,COG0230@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL34 family KOPIJCMJ_03079 888439.HMPREF9240_01622 6.9e-24 116.7 Actinobacteria yidD ko:K08998 ko00000 Bacteria 2GQZG@201174,4D6B8@85005,COG0759@1,COG0759@2 NA|NA|NA S Could be involved in insertion of integral membrane proteins into the membrane KOPIJCMJ_03080 1504319.GM45_6245 3e-88 332.0 unclassified Actinobacteria (class) yidC ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 Bacteria 2GJBU@201174,3UWKK@52018,COG0706@1,COG0706@2 NA|NA|NA U 60Kd inner membrane protein KOPIJCMJ_03081 1157637.KB892093_gene6652 7.8e-50 203.4 Actinobacteria jag ko:K06346,ko:K09749 ko00000 Bacteria 2GPZK@201174,COG1847@1,COG1847@2 NA|NA|NA S R3H domain protein KOPIJCMJ_03082 585531.HMPREF0063_10409 1.3e-50 206.5 Propionibacteriales rsmG GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 ko:K03501 ko00000,ko01000,ko03009,ko03036 Bacteria 2GM9Z@201174,4DQN8@85009,COG0357@1,COG0357@2 NA|NA|NA M Specifically methylates the N7 position of a guanine in 16S rRNA KOPIJCMJ_03083 1449353.JQMQ01000005_gene485 2.6e-11 74.7 Actinobacteria Bacteria 2BNAP@1,2GTB3@201174,32GYA@2 NA|NA|NA KOPIJCMJ_03084 743721.Psesu_0725 9.4e-157 559.7 Xanthomonadales gapA GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0042866,GO:0043436,GO:0043891,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 iAPECO1_1312.APECO1_847,iPC815.YPO2157,iUTI89_1310.UTI89_C1975,ic_1306.c2184 Bacteria 1MU93@1224,1RMBM@1236,1X34S@135614,COG0057@1,COG0057@2 NA|NA|NA G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family KOPIJCMJ_03085 66377.JOBH01000004_gene3779 6.5e-48 198.0 Actinobacteria Bacteria 2A4ZY@1,2GMC5@201174,30TN1@2 NA|NA|NA KOPIJCMJ_03086 187303.BN69_3335 1e-55 224.2 Alphaproteobacteria GO:0003674,GO:0003824,GO:0006629,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0044237,GO:0044238,GO:0044255,GO:0071704 ko:K07019 ko00000 Bacteria 1MWV1@1224,2TSMR@28211,COG0429@1,COG0429@2 NA|NA|NA S alpha/beta hydrolase fold KOPIJCMJ_03087 1123487.KB892846_gene459 1.8e-108 399.1 Proteobacteria supH Bacteria 1Q5HK@1224,COG0561@1,COG0561@2 NA|NA|NA C Hydrolase KOPIJCMJ_03088 105420.BBPO01000052_gene1853 1.2e-29 136.7 Streptacidiphilus Bacteria 2H3AT@201174,2NGQ3@228398,COG3247@1,COG3247@2 NA|NA|NA S Short repeat of unknown function (DUF308) KOPIJCMJ_03089 223184.AS25_06030 8.4e-33 146.7 Micrococcaceae Bacteria 1W9QW@1268,2IFHE@201174,COG5010@1,COG5010@2 NA|NA|NA U COG0457 FOG TPR repeat KOPIJCMJ_03090 110319.CF8_2787 2.4e-85 322.0 Propionibacteriales dapB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0055114,GO:0070402,GO:0070404,GO:0071704,GO:0071944,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 iJN678.dapB,iNJ661.Rv2773c,iYO844.BSU22490 Bacteria 2GM2T@201174,4DNG2@85009,COG0289@1,COG0289@2 NA|NA|NA E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate KOPIJCMJ_03091 1123320.KB889675_gene4004 1.3e-142 513.1 Actinobacteria pepR GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 2GJZ3@201174,COG0612@1,COG0612@2 NA|NA|NA S Belongs to the peptidase M16 family KOPIJCMJ_03092 266940.Krad_1466 6.5e-26 123.6 Actinobacteria pnp GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 Bacteria 2GIT2@201174,COG1185@1,COG1185@2 NA|NA|NA J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction KOPIJCMJ_03094 110319.CF8_1908 1.8e-73 283.5 Propionibacteriales mltG ko:K07082 ko00000 Bacteria 2GKGQ@201174,4DN3K@85009,COG1559@1,COG1559@2 NA|NA|NA S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation KOPIJCMJ_03095 1210045.ALNP01000016_gene1959 6e-64 251.1 Actinobacteria aroE GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv2552c Bacteria 2GPQQ@201174,COG0169@1,COG0169@2 NA|NA|NA E Shikimate dehydrogenase KOPIJCMJ_03096 861299.J421_3061 1.1e-08 68.6 Gemmatimonadetes Bacteria 1ZSPN@142182,COG0457@1,COG0457@2 NA|NA|NA S Domain of unknown function (DUF4388) KOPIJCMJ_03097 351607.Acel_1322 3.3e-223 781.2 Frankiales pulE ko:K02652 ko00000,ko02035,ko02044 3.A.15.2 Bacteria 2I8C2@201174,4ES0V@85013,COG2804@1,COG2804@2 NA|NA|NA NU General secretory system II, protein E domain protein KOPIJCMJ_03098 590998.Celf_2006 1.3e-151 543.1 Actinobacteria pilT ko:K02669 ko00000,ko02035,ko02044 3.A.15.2 Bacteria 2I9GT@201174,COG2805@1,COG2805@2 NA|NA|NA NU twitching motility protein KOPIJCMJ_03099 351607.Acel_1320 2.6e-153 548.5 Frankiales pilC ko:K02653 ko00000,ko02035,ko02044 3.A.15.2 Bacteria 2GQW0@201174,4ERP7@85013,COG1459@1,COG1459@2 NA|NA|NA NU Type II secretion system (T2SS), protein F KOPIJCMJ_03100 935866.JAER01000009_gene774 1.5e-170 606.3 Propionibacteriales fadD3 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 Bacteria 2GIXQ@201174,4DPPW@85009,COG1022@1,COG1022@2 NA|NA|NA I AMP-binding enzyme KOPIJCMJ_03101 1122611.KB903944_gene1165 2e-08 65.9 Streptosporangiales Bacteria 2C5NN@1,2GV7Y@201174,2ZJPF@2,4EKGV@85012 NA|NA|NA KOPIJCMJ_03102 1095767.CAHD01000205_gene850 9.5e-18 96.7 Bacteria pilA ko:K02650 ko02020,map02020 ko00000,ko00001,ko02035,ko02044 3.A.15.2 Bacteria COG2165@1,COG2165@2 NA|NA|NA NU general secretion pathway protein KOPIJCMJ_03103 1048339.KB913029_gene1850 4.2e-38 166.0 Actinobacteria pilV GO:0003674,GO:0005198,GO:0005575,GO:0005623,GO:0008150,GO:0009289,GO:0009405,GO:0009987,GO:0016043,GO:0030030,GO:0042995,GO:0044419,GO:0044464,GO:0051704,GO:0071840 ko:K02457,ko:K02458,ko:K10926,ko:K10930,ko:K10931 ko03070,ko05110,ko05111,map03070,map05110,map05111 M00331 ko00000,ko00001,ko00002,ko02044 3.A.15 Bacteria 2IHD8@201174,COG2165@1,COG2165@2 NA|NA|NA NU general secretion pathway protein KOPIJCMJ_03104 1304865.JAGF01000001_gene3205 7.6e-12 77.8 Actinobacteria Bacteria 2FCR1@1,2H815@201174,344U8@2 NA|NA|NA KOPIJCMJ_03105 593907.Celgi_1807 1.2e-91 344.4 Actinobacteria Bacteria 2ID24@201174,COG4726@1,COG4726@2 NA|NA|NA NU pilus assembly protein PilW KOPIJCMJ_03106 593907.Celgi_1803 3.5e-71 275.0 Cellulomonadaceae hofD 3.4.23.43 ko:K02654 M00331 ko00000,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15.2 Bacteria 2GJ7K@201174,4F1IU@85016,COG1989@1,COG1989@2 NA|NA|NA NOU Type IV leader peptidase family KOPIJCMJ_03107 1306174.JODP01000013_gene7517 1.3e-68 266.9 Actinobacteria pilM ko:K02662 ko00000,ko02035,ko02044 Bacteria 2IBNF@201174,COG4972@1,COG4972@2 NA|NA|NA NU pilus assembly protein PilM KOPIJCMJ_03108 593907.Celgi_1801 6.1e-17 94.7 Actinobacteria pilN ko:K02663 ko00000,ko02035,ko02044 Bacteria 2IS0C@201174,COG3166@1,COG3166@2 NA|NA|NA NU PFAM Fimbrial assembly family protein KOPIJCMJ_03109 266940.Krad_3017 5.1e-08 65.1 Bacteria mshJ ko:K02664,ko:K02665,ko:K12280 ko00000,ko02035,ko02044 Bacteria COG3167@1,COG3167@2 NA|NA|NA NU carbon utilization KOPIJCMJ_03111 1184609.KILIM_066_00310 1.6e-81 308.9 Dermatophilaceae Bacteria 2GY1D@201174,4F7U4@85018,COG0454@1,COG0456@2 NA|NA|NA K Acetyltransferase (GNAT) family KOPIJCMJ_03112 196162.Noca_1250 1.8e-12 79.0 Propionibacteriales pccA 2.1.3.1,6.4.1.3 ko:K01965,ko:K17490 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R00353,R01859 RC00040,RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 Bacteria 2GPU3@201174,4DVQ9@85009,COG4770@1,COG4770@2 NA|NA|NA I Biotin-lipoyl like KOPIJCMJ_03113 479435.Kfla_3207 8.2e-90 337.0 Propionibacteriales recB 3.6.4.12 ko:K03657,ko:K07465 ko03420,ko03430,map03420,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 2GJC5@201174,4DP6M@85009,COG2887@1,COG2887@2 NA|NA|NA L Protein of unknown function (DUF2800) KOPIJCMJ_03114 1120950.KB892708_gene4422 8.8e-63 247.7 Propionibacteriales Bacteria 2GJBZ@201174,4DNGY@85009,COG1994@1,COG1994@2 NA|NA|NA S Belongs to the peptidase M50B family KOPIJCMJ_03115 1137269.AZWL01000002_gene6306 2.5e-112 412.1 Actinobacteria trmI GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016426,GO:0016429,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.219,2.1.1.220 ko:K07442 ko00000,ko01000,ko03016 Bacteria 2GJPD@201174,COG2519@1,COG2519@2 NA|NA|NA J Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA KOPIJCMJ_03116 1123320.KB889667_gene2958 1.5e-241 842.0 Actinobacteria arc GO:0000302,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0010499,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0019941,GO:0022623,GO:0022624,GO:0030163,GO:0030312,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042802,GO:0043170,GO:0043335,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044877,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070628,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097366,GO:0140030,GO:0140035,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1902494,GO:1905368,GO:1905369 ko:K13527 ko03050,map03050 M00342 ko00000,ko00001,ko00002,ko03051 Bacteria 2GMR1@201174,COG1222@1,COG1222@2 NA|NA|NA O AAA ATPase forming ring-shaped complexes KOPIJCMJ_03117 1146883.BLASA_1226 1e-75 290.0 Bacteria Bacteria COG0457@1,COG0457@2,COG3012@1,COG3012@2 NA|NA|NA S peptidyl-tyrosine sulfation KOPIJCMJ_03118 1146883.BLASA_1225 9.1e-150 536.6 Frankiales ko:K07484 ko00000 Bacteria 2I9XB@201174,4ESZK@85013,COG4974@1,COG4974@2 NA|NA|NA L Evidence 4 Homologs of previously reported genes of KOPIJCMJ_03119 1122239.AULS01000004_gene1469 8.2e-24 115.9 Microbacteriaceae Bacteria 2GWBV@201174,4FMA0@85023,COG1672@1,COG1672@2 NA|NA|NA S AAA ATPase domain KOPIJCMJ_03120 1132441.KI519454_gene683 7.7e-141 507.3 Micrococcaceae glnP ko:K02029,ko:K02030 M00236 ko00000,ko00002,ko02000 3.A.1.3 Bacteria 1W836@1268,2GJJ9@201174,COG0765@1,COG0765@2,COG0834@1,COG0834@2 NA|NA|NA P Bacterial extracellular solute-binding proteins, family 3 KOPIJCMJ_03121 1001240.GY21_10825 3e-91 341.7 Microbacteriaceae glnQ 3.6.3.21 ko:K02028,ko:K10038 ko02010,map02010 M00227,M00236 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3,3.A.1.3.2 Bacteria 2GIZW@201174,4FKHI@85023,COG1126@1,COG1126@2 NA|NA|NA E ATPases associated with a variety of cellular activities KOPIJCMJ_03122 1121385.AQXW01000002_gene17 1.4e-37 164.5 Bacteria Bacteria COG5555@1,COG5555@2 NA|NA|NA KOPIJCMJ_03123 446466.Cfla_2117 3.1e-96 359.8 Actinobacteria yteR_10 Bacteria 2I8PZ@201174,COG1409@1,COG1409@2,COG4225@1,COG4225@2 NA|NA|NA G Glycosyl Hydrolase Family 88 KOPIJCMJ_03124 1122933.JNIY01000003_gene63 8e-48 196.8 Actinobacteria ko:K21429 ko00000,ko01002 Bacteria 2GKWI@201174,COG4894@1,COG4894@2 NA|NA|NA S LURP-one-related KOPIJCMJ_03125 675635.Psed_4822 1.5e-88 333.6 Pseudonocardiales Bacteria 2GM17@201174,4DYVE@85010,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor KOPIJCMJ_03126 1205910.B005_2789 1.4e-79 302.8 Streptosporangiales Bacteria 2GIZB@201174,4ENVQ@85012,COG0745@1,COG0745@2 NA|NA|NA T Transcriptional regulatory protein, C terminal KOPIJCMJ_03127 1380390.JIAT01000011_gene2386 4.4e-14 84.7 Rubrobacteria Bacteria 2FDZX@1,2IN56@201174,34604@2,4CT9G@84995 NA|NA|NA KOPIJCMJ_03128 983917.RGE_30170 1.7e-25 122.9 Bacteria ko:K03830 ko00000,ko01000 Bacteria COG1246@1,COG1246@2 NA|NA|NA E Belongs to the acetyltransferase family. ArgA subfamily KOPIJCMJ_03129 367299.JOEE01000003_gene2888 1.6e-11 75.9 Intrasporangiaceae Bacteria 2HNF3@201174,4FHWW@85021,COG5652@1,COG5652@2 NA|NA|NA S VanZ like family KOPIJCMJ_03132 477641.MODMU_3312 3.8e-128 464.9 Frankiales coaBC GO:0003674,GO:0003824,GO:0004633,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016020,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJGJ@201174,4ERES@85013,COG0452@1,COG0452@2 NA|NA|NA H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine KOPIJCMJ_03133 1306174.JODP01000013_gene7494 1.9e-32 144.8 Actinobacteria rpoZ GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 Bacteria 2IQHU@201174,COG1758@1,COG1758@2 NA|NA|NA K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits KOPIJCMJ_03134 221359.RS9916_33432 1.5e-55 222.6 Synechococcus gmk GO:0003674,GO:0003824,GO:0004385,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8,4.1.1.23 ko:K00942,ko:K01591 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00050,M00051 R00332,R00965,R02090 RC00002,RC00409 ko00000,ko00001,ko00002,ko01000 iAPECO1_1312.APECO1_2813,iIT341.HP0321,iPC815.YPO0040,iSBO_1134.SBO_3729,iSFV_1184.SFV_3881,iSFxv_1172.SFxv_4016,iUTI89_1310.UTI89_C4193 Bacteria 1G515@1117,1GZ3I@1129,COG0194@1,COG0194@2 NA|NA|NA F Essential for recycling GMP and indirectly, cGMP KOPIJCMJ_03135 1150398.JIBJ01000004_gene2893 5.3e-14 84.0 Micrococcaceae mihF 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 1W9UW@1268,2IKPU@201174,COG0099@1,COG0099@2 NA|NA|NA J integration host factor KOPIJCMJ_03136 367299.JOEE01000005_gene3489 1.4e-69 269.6 Intrasporangiaceae ribD GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0008703,GO:0008835,GO:0009058,GO:0009110,GO:0009231,GO:0009451,GO:0009987,GO:0016020,GO:0016070,GO:0016491,GO:0016614,GO:0016616,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0034641,GO:0036094,GO:0040007,GO:0042364,GO:0042726,GO:0042727,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.1.1.193,3.5.4.26 ko:K01498,ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1624,iB21_1397.B21_00366,iECBD_1354.ECBD_3247,iECB_1328.ECB_00362,iECD_1391.ECD_00362,iECED1_1282.ECED1_0437,iECNA114_1301.ECNA114_0391,iECSF_1327.ECSF_0374,iEcolC_1368.EcolC_3219,iJN746.PP_0514,iLF82_1304.LF82_1880,iLJ478.TM1828,iNRG857_1313.NRG857_01945,iYL1228.KPN_00366,ic_1306.c0524 Bacteria 2GKAX@201174,4FEKV@85021,COG0117@1,COG0117@2,COG1985@1,COG1985@2 NA|NA|NA H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate KOPIJCMJ_03137 1449355.JQNR01000005_gene5307 4.2e-64 251.1 Actinobacteria ribE GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.9,3.5.4.25,4.1.99.12 ko:K00793,ko:K02858,ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00066,R00425,R07281 RC00293,RC00958,RC00960,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS08950 Bacteria 2GKC5@201174,COG0307@1,COG0307@2 NA|NA|NA H riboflavin synthase, alpha KOPIJCMJ_03138 1123320.KB889596_gene8708 2.5e-152 545.4 Actinobacteria ribBA 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 Bacteria 2GIWJ@201174,COG0108@1,COG0108@2,COG0807@1,COG0807@2 NA|NA|NA H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate KOPIJCMJ_03139 1115803.HMPREF1129_0933 6.9e-50 203.8 Actinobacteria ribH 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 Bacteria 2II1Z@201174,4D5BA@85005,COG0054@1,COG0054@2 NA|NA|NA H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin KOPIJCMJ_03140 1121946.AUAX01000008_gene7170 6.2e-28 129.8 Micromonosporales hisE GO:0000105,GO:0000287,GO:0003674,GO:0003824,GO:0004635,GO:0004636,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0043167,GO:0043169,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052803,GO:0071704,GO:0071944,GO:0075136,GO:0075139,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.4.19,3.6.1.31,5.3.1.16 ko:K01523,ko:K01814,ko:K11755 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035,R04037,R04640 RC00002,RC00945,RC01055 ko00000,ko00001,ko00002,ko01000 iECNA114_1301.ECNA114_0880,iECW_1372.ECW_m2186,iEKO11_1354.EKO11_1768,iSB619.SA_RS14110,iUMN146_1321.UM146_06665,iWFL_1372.ECW_m2186,iYO844.BSU34860 Bacteria 2IQ4D@201174,4DF5K@85008,COG0140@1,COG0140@2 NA|NA|NA E Phosphoribosyl-ATP KOPIJCMJ_03141 1120950.KB892707_gene4712 1e-92 346.7 Propionibacteriales hisG GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 Bacteria 2GNAX@201174,4DNZB@85009,COG0040@1,COG0040@2 NA|NA|NA E ATP phosphoribosyltransferase KOPIJCMJ_03142 543632.JOJL01000005_gene4762 2.8e-23 114.8 Actinobacteria Bacteria 2I2Z1@201174,COG0745@1,COG0745@2 NA|NA|NA T Response regulator receiver KOPIJCMJ_03143 543632.JOJL01000005_gene4760 1.8e-110 407.1 Actinobacteria Bacteria 2I2TP@201174,COG5002@1,COG5002@2 NA|NA|NA T Histidine kinase KOPIJCMJ_03145 1169154.KB897784_gene4300 2.2e-51 209.5 Actinobacteria Bacteria 2GKX5@201174,COG0457@1,COG0457@2 NA|NA|NA A Belongs to the DEAD box helicase family KOPIJCMJ_03146 452652.KSE_57300 2.2e-79 302.8 Kitasatospora yutF GO:0000121,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009395,GO:0009987,GO:0016042,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0030145,GO:0042578,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0046434,GO:0046475,GO:0046486,GO:0046503,GO:0046872,GO:0046914,GO:0046983,GO:0050897,GO:0071704,GO:1901575 3.1.3.41 ko:K01101 ko00627,ko01120,map00627,map01120 R03024 RC00151 ko00000,ko00001,ko01000 Bacteria 2GK7V@201174,2M1NB@2063,COG0647@1,COG0647@2 NA|NA|NA G Haloacid dehalogenase-like hydrolase KOPIJCMJ_03149 479433.Caci_5431 4.7e-87 327.8 Actinobacteria tlyA GO:0000154,GO:0001510,GO:0001897,GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019835,GO:0019836,GO:0022613,GO:0031167,GO:0031640,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035821,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044003,GO:0044004,GO:0044085,GO:0044179,GO:0044237,GO:0044238,GO:0044260,GO:0044364,GO:0044403,GO:0044419,GO:0044764,GO:0046483,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.226,2.1.1.227 ko:K06442 ko00000,ko01000,ko03009 Bacteria 2GJVT@201174,COG1189@1,COG1189@2 NA|NA|NA J Ribosomal RNA methyltransferase RrmJ FtsJ KOPIJCMJ_03150 1048339.KB913029_gene4067 4.8e-96 357.8 Frankiales nadK GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0006082,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006793,GO:0006796,GO:0006797,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 R00104 RC00002,RC00078 ko00000,ko00001,ko01000 Bacteria 2GKM2@201174,4ERHI@85013,COG0061@1,COG0061@2 NA|NA|NA G Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP KOPIJCMJ_03151 66875.JODY01000020_gene275 6.2e-132 478.0 Actinobacteria recN GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0030312,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:1901360 ko:K03631,ko:K13582 ko04112,map04112 ko00000,ko00001,ko03400 Bacteria 2GIVG@201174,COG0497@1,COG0497@2 NA|NA|NA L May be involved in recombinational repair of damaged DNA KOPIJCMJ_03152 455632.SGR_872 2.3e-10 71.6 Actinobacteria ko:K03088 ko00000,ko03021 Bacteria 2IRNG@201174,COG1595@1,COG1595@2 NA|NA|NA K belongs to the sigma-70 factor family, ECF subfamily KOPIJCMJ_03154 1172179.AUKV01000005_gene5828 3e-24 118.2 Actinobacteria ko:K03088 ko00000,ko03021 Bacteria 2IKVM@201174,COG1595@1,COG1595@2 NA|NA|NA K belongs to the sigma-70 factor family, ECF subfamily KOPIJCMJ_03158 644548.SCNU_00065 2e-30 140.2 Gordoniaceae Bacteria 2GMMI@201174,4GD92@85026,COG0582@1,COG0582@2 NA|NA|NA L Belongs to the 'phage' integrase family KOPIJCMJ_03160 195250.CM001776_gene2666 1.3e-21 110.9 Synechococcus tir 3.4.11.19 ko:K01266,ko:K07052 ko00000,ko01000,ko01002 Bacteria 1G6D9@1117,1H119@1129,COG1266@1,COG1266@2 NA|NA|NA S CAAX protease self-immunity KOPIJCMJ_03161 1385518.N798_04100 1.4e-14 86.7 Intrasporangiaceae Bacteria 2GTTI@201174,4FGNQ@85021,COG3976@1,COG3976@2 NA|NA|NA S FMN_bind KOPIJCMJ_03162 1380390.JIAT01000011_gene2397 4.1e-110 405.2 Rubrobacteria Bacteria 2GKWX@201174,4CRXT@84995,COG4097@1,COG4097@2 NA|NA|NA P FAD-binding domain KOPIJCMJ_03163 1214242.B446_25490 3.6e-74 285.8 Actinobacteria treS 2.4.1.18,2.7.1.175,3.2.1.1,5.4.99.16 ko:K00700,ko:K05343,ko:K16146 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01557,R02108,R02110,R02112,R09945,R11262 RC00002,RC00078,RC01816 ko00000,ko00001,ko00002,ko01000,ko04147 CBM48,GH13 Bacteria 2GKAP@201174,COG3281@1,COG3281@2 NA|NA|NA G protein, probably involved in trehalose biosynthesis KOPIJCMJ_03164 1463864.JOGO01000009_gene433 1.6e-51 209.1 Actinobacteria Bacteria 299E4@1,2GM90@201174,2ZWGX@2 NA|NA|NA S Protein of unknown function (DUF3145) KOPIJCMJ_03165 1283283.ATXA01000038_gene2291 1.3e-63 250.4 Actinobacteria Bacteria 2IAG8@201174,COG3386@1,COG3386@2 NA|NA|NA G PFAM SMP-30 Gluconolaconase KOPIJCMJ_03167 1150864.MILUP08_40902 9.6e-27 127.9 Micromonosporales ko:K18566 ko00332,ko01130,map00332,map01130 R10745,R10746 RC00004,RC00096 ko00000,ko00001,ko01000 Bacteria 2I9GA@201174,4DD5V@85008,COG0454@1,COG0456@2 NA|NA|NA K Acetyltransferase (GNAT) family KOPIJCMJ_03168 477641.MODMU_1853 1.9e-284 984.9 Frankiales aceE 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GJRE@201174,4ESAA@85013,COG2609@1,COG2609@2 NA|NA|NA C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) KOPIJCMJ_03169 479435.Kfla_2948 2.4e-58 232.3 Propionibacteriales Bacteria 2B34Q@1,2I2K1@201174,2ZK49@2,4DX2H@85009 NA|NA|NA KOPIJCMJ_03172 1120950.KB892745_gene2878 1.4e-85 323.2 Propionibacteriales atpG GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 iLJ478.TM1611,iSSON_1240.SSON_3886,iYL1228.KPN_04138 Bacteria 2GJ7Q@201174,4DN4I@85009,COG0224@1,COG0224@2 NA|NA|NA C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex KOPIJCMJ_03173 469371.Tbis_0898 2.4e-234 818.1 Pseudonocardiales atpA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 iIT341.HP1134,iSB619.SA_RS10975,iSbBS512_1146.SbBS512_E4187 Bacteria 2GJRJ@201174,4E0X3@85010,COG0056@1,COG0056@2 NA|NA|NA C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit KOPIJCMJ_03174 1343740.M271_17085 5.7e-48 198.0 Actinobacteria atpH ko:K02109,ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 Bacteria 2GMJ5@201174,COG0712@1,COG0712@2 NA|NA|NA C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation KOPIJCMJ_03175 1122175.ATXU01000001_gene931 5.5e-34 151.0 Microbacteriaceae atpF ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 Bacteria 2GJS4@201174,4FNEE@85023,COG0711@1,COG0711@2 NA|NA|NA C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) KOPIJCMJ_03176 1504319.GM45_6080 1.5e-27 128.3 unclassified Actinobacteria (class) atpE GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 Bacteria 2HGDC@201174,3UWZI@52018,COG0636@1,COG0636@2 NA|NA|NA C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation KOPIJCMJ_03177 1504319.GM45_6075 1.7e-68 266.2 unclassified Actinobacteria (class) atpB ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 Bacteria 2H3PR@201174,3UWN7@52018,COG0356@1,COG0356@2 NA|NA|NA C it plays a direct role in the translocation of protons across the membrane KOPIJCMJ_03178 1504319.GM45_6070 7.2e-14 83.2 Bacteria Bacteria 2972E@1,2ZUAS@2 NA|NA|NA KOPIJCMJ_03179 1713.JOFV01000002_gene496 1.1e-10 73.2 Cellulomonadaceae atpI ko:K02116 ko00000,ko00194 3.A.2.1 Bacteria 2BJAR@1,2GR4T@201174,32DKN@2,4F1BV@85016 NA|NA|NA KOPIJCMJ_03180 1504319.GM45_6060 3.4e-91 342.0 unclassified Actinobacteria (class) tagO GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0034645,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0045229,GO:0046872,GO:0046914,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:1901576 2.7.8.33,2.7.8.35 ko:K02851 R08856 RC00002 ko00000,ko01000,ko01003,ko01005 Bacteria 2GIT7@201174,3UWGE@52018,COG0472@1,COG0472@2 NA|NA|NA M Glycosyl transferase family 4 KOPIJCMJ_03181 1123251.ATWM01000003_gene1217 1.7e-18 98.2 Intrasporangiaceae glyA 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 Bacteria 2GK7U@201174,4FEQF@85021,COG0112@1,COG0112@2 NA|NA|NA E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism KOPIJCMJ_03183 979556.MTES_2076 1e-73 283.9 Actinobacteria ko:K02529 ko00000,ko03000 Bacteria 2GKFC@201174,COG1609@1,COG1609@2 NA|NA|NA K transcriptional regulator KOPIJCMJ_03185 326424.FRAAL6133 4.8e-234 817.0 Frankiales typA GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840 ko:K06207 ko00000 Bacteria 2GJUJ@201174,4ES8A@85013,COG1217@1,COG1217@2 NA|NA|NA T GTP-binding protein TypA KOPIJCMJ_03186 1122182.KB903813_gene2505 5.2e-80 305.4 Micromonosporales ko:K02035,ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 2GIUH@201174,4DBF2@85008,COG4166@1,COG4166@2 NA|NA|NA E extracellular solute-binding protein KOPIJCMJ_03187 1385520.N802_16405 5.5e-87 327.8 Intrasporangiaceae ko:K02033,ko:K13890,ko:K15581 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00348,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.11,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 2GJ2C@201174,4FEQC@85021,COG0601@1,COG0601@2 NA|NA|NA U ABC transporter (Permease) KOPIJCMJ_03188 1123320.KB889719_gene7333 4.6e-73 281.6 Actinobacteria oppC ko:K02034,ko:K15582 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 2GJ9E@201174,COG1173@1,COG1173@2 NA|NA|NA EP PFAM binding-protein-dependent transport systems inner membrane component KOPIJCMJ_03189 1463820.JOGW01000003_gene7196 5.7e-114 417.5 Actinobacteria dppD ko:K02031,ko:K02032,ko:K15583 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 2GIXV@201174,COG0444@1,COG0444@2 NA|NA|NA EP Belongs to the ABC transporter superfamily KOPIJCMJ_03190 66377.JOBH01000017_gene2936 1e-121 443.4 Actinobacteria ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 2H4BW@201174,COG4608@1,COG4608@2 NA|NA|NA E Belongs to the ABC transporter superfamily KOPIJCMJ_03191 1048339.KB913029_gene2175 4e-27 129.0 Frankiales bldKE ko:K02032,ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 2H4BW@201174,4EUB4@85013,COG4608@1,COG4608@2 NA|NA|NA P Oligopeptide/dipeptide transporter, C-terminal region KOPIJCMJ_03192 1449353.JQMQ01000005_gene2404 1.1e-97 363.2 Streptacidiphilus mshB 3.5.1.103 ko:K15525 ko00000,ko01000 Bacteria 2GKUM@201174,2NET5@228398,COG2120@1,COG2120@2 NA|NA|NA S GlcNAc-PI de-N-acetylase KOPIJCMJ_03193 68223.JNZY01000001_gene5613 6.6e-75 287.3 Actinobacteria ppgK 2.7.1.2,2.7.1.63 ko:K00845,ko:K00886 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786,R02187,R02189 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJA0@201174,COG1940@1,COG1940@2 NA|NA|NA GK polyphosphate glucokinase KOPIJCMJ_03194 266940.Krad_1135 2.7e-197 695.3 Actinobacteria ftsH ko:K03798 M00742 ko00000,ko00002,ko01000,ko01002,ko03110 Bacteria 2I9X7@201174,COG0465@1,COG0465@2 NA|NA|NA O Belongs to the AAA ATPase family KOPIJCMJ_03195 1386089.N865_11735 1.3e-144 519.2 Intrasporangiaceae gltA 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ7E@201174,4FEQ1@85021,COG0372@1,COG0372@2 NA|NA|NA C Belongs to the citrate synthase family KOPIJCMJ_03196 44454.NF84_07330 1.4e-278 966.5 Mycobacteriaceae fas 2.3.1.179 ko:K09458,ko:K11533 ko00061,ko00780,ko01100,ko01212,ko04931,map00061,map00780,map01100,map01212,map04931 M00082,M00083,M00572 R01624,R01626,R04355,R04428,R04429,R04533,R04534,R04535,R04536,R04537,R04543,R04544,R04566,R04568,R04724,R04726,R04952,R04953,R04954,R04955,R04957,R04958,R04960,R04961,R04963,R04964,R04965,R04966,R04968,R04969,R07762,R07763,R07764,R07765,R10115,R10119,R10700 RC00004,RC00029,RC00039,RC00052,RC00076,RC00117,RC00831,RC01095,RC02727,RC02728,RC02729,RC02857,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 234D6@1762,2GIY4@201174,COG0304@1,COG0304@2,COG0331@1,COG0331@2,COG2030@1,COG2030@2,COG4981@1,COG4981@2 NA|NA|NA IQ synthase KOPIJCMJ_03197 1078020.KEK_17748 6e-25 120.6 Mycobacteriaceae acpS GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008897,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016780,GO:0018070,GO:0018193,GO:0018209,GO:0018215,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576 2.7.8.7,3.2.1.52 ko:K00997,ko:K01207 ko00520,ko00531,ko00770,ko01100,ko01501,map00520,map00531,map00770,map01100,map01501 M00628 R00022,R01625,R05963,R07809,R07810,R10831 RC00002,RC00049 ko00000,ko00001,ko00002,ko01000 Bacteria 238KS@1762,2IQF6@201174,COG0736@1,COG0736@2 NA|NA|NA I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein KOPIJCMJ_03198 585531.HMPREF0063_11333 1.5e-43 183.0 Propionibacteriales Bacteria 2IDJT@201174,4DSNS@85009,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family KOPIJCMJ_03199 33898.JRHJ01000025_gene6653 2.2e-26 126.7 Actinobacteria Bacteria 2GXEC@201174,COG0739@1,COG0739@2 NA|NA|NA M peptidase KOPIJCMJ_03201 1112204.GPOL_c41030 6.2e-109 401.4 Gordoniaceae Bacteria 2GKU0@201174,4GD5R@85026,COG1020@1,COG1020@2 NA|NA|NA Q Protein of unknown function (DUF1298) KOPIJCMJ_03202 1123321.KB905830_gene755 8.5e-133 480.7 Actinobacteria pmt 2.4.1.109 ko:K00728 ko00514,ko00515,ko01100,map00514,map00515,map01100 R04072,R07620,R11399 RC00005,RC00059,RC00397 ko00000,ko00001,ko01000,ko01003 GT39 Bacteria 2I2H1@201174,COG1928@1,COG1928@2 NA|NA|NA O PFAM glycosyl transferase family 39 KOPIJCMJ_03203 105422.BBPM01000063_gene497 1.1e-87 330.1 Streptacidiphilus rsmI GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.198 ko:K07056 ko00000,ko01000,ko03009 Bacteria 2GJ9Q@201174,2NEIU@228398,COG0313@1,COG0313@2 NA|NA|NA H Tetrapyrrole (Corrin/Porphyrin) Methylases KOPIJCMJ_03204 351607.Acel_0175 9.3e-207 726.5 Frankiales metG GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 2GK4S@201174,4ES23@85013,COG0143@1,COG0143@2 NA|NA|NA J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation KOPIJCMJ_03205 1122609.AUGT01000017_gene965 3.2e-81 308.5 Propionibacteriales tatD ko:K03424 ko00000,ko01000 Bacteria 2GMJJ@201174,4DPJ5@85009,COG0084@1,COG0084@2 NA|NA|NA L TatD related DNase KOPIJCMJ_03206 67257.JODR01000011_gene5452 5.9e-88 330.9 Actinobacteria ksgA GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 ko:K02528 R10716 RC00003,RC03257 ko00000,ko01000,ko03009 Bacteria 2GKBT@201174,COG0030@1,COG0030@2 NA|NA|NA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits KOPIJCMJ_03207 1032480.MLP_27790 7.1e-88 331.3 Propionibacteriales Bacteria 2GP0C@201174,4DS7R@85009,COG1409@1,COG1409@2 NA|NA|NA S Calcineurin-like phosphoesterase KOPIJCMJ_03208 446471.Xcel_2724 7.4e-76 290.8 Promicromonosporaceae ispE GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006629,GO:0006720,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0050515,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901576 2.1.1.182,2.7.1.148 ko:K00919,ko:K02528,ko:K16924 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096,M00582 R05634,R10716 RC00002,RC00003,RC01439,RC03257 ko00000,ko00001,ko00002,ko01000,ko02000,ko03009 3.A.1.29 iEC55989_1330.EC55989_1304,iLJ478.TM1383,iYO844.BSU00460 Bacteria 2GKXD@201174,4F3UP@85017,COG1947@1,COG1947@2 NA|NA|NA I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol KOPIJCMJ_03209 1304865.JAGF01000001_gene92 2.7e-59 236.5 Actinobacteria manA 5.3.1.8 ko:K01809 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01819 RC00376 ko00000,ko00001,ko00002,ko01000 Bacteria 2I8X4@201174,COG1482@1,COG1482@2 NA|NA|NA G mannose-6-phosphate isomerase KOPIJCMJ_03212 35754.JNYJ01000028_gene6039 6e-07 62.4 Micromonosporales int ko:K06400 ko00000 Bacteria 2I8HV@201174,4DM0R@85008,COG1961@1,COG1961@2 NA|NA|NA L Recombinase zinc beta ribbon domain KOPIJCMJ_03215 686340.Metal_2787 3.3e-133 481.9 Proteobacteria cpgS ko:K05716 R03298 RC00900 ko00000,ko01000 Bacteria 1MV4C@1224,COG2403@1,COG2403@2 NA|NA|NA S cyclic 2,3-diphosphoglycerate synthetase activity KOPIJCMJ_03216 593907.Celgi_2417 1.8e-164 585.5 Cellulomonadaceae pfkA 2.7.1.11,2.7.1.90 ko:K00850,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 iJN678.pfkA Bacteria 2GK6W@201174,4F0UZ@85016,COG0205@1,COG0205@2 NA|NA|NA H Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis KOPIJCMJ_03217 1150399.AQYK01000002_gene3209 4.5e-185 655.2 Microbacteriaceae Bacteria 2GN7G@201174,4FKX3@85023,COG3291@1,COG3291@2 NA|NA|NA G Repeats in polycystic kidney disease 1 (PKD1) and other proteins KOPIJCMJ_03218 1035308.AQYY01000002_gene896 1.2e-20 105.9 Bacteria Bacteria 2DNVN@1,32ZD5@2 NA|NA|NA S Lsr2 KOPIJCMJ_03219 1380370.JIBA01000015_gene318 2.6e-60 239.6 Intrasporangiaceae Bacteria 2GK3A@201174,4FFEB@85021,COG1680@1,COG1680@2 NA|NA|NA V Beta-lactamase KOPIJCMJ_03220 1504672.669787050 2.2e-11 75.9 Comamonadaceae Bacteria 1R95F@1224,28J0Q@1,2VJZ5@28216,2Z8XV@2,4A9RS@80864 NA|NA|NA KOPIJCMJ_03222 411483.FAEPRAA2165_03445 9.4e-75 287.0 Ruminococcaceae ko:K05833 M00247 ko00000,ko00002,ko02000 Bacteria 1TPAN@1239,247WW@186801,3WHK4@541000,COG1101@1,COG1101@2 NA|NA|NA S Psort location CytoplasmicMembrane, score KOPIJCMJ_03223 574087.Acear_1446 1.2e-73 283.5 Halanaerobiales WQ51_06230 ko:K01989,ko:K05832,ko:K05833 M00247 ko00000,ko00002,ko02000 Bacteria 1TPDJ@1239,249P1@186801,3WA9B@53433,COG4120@1,COG4120@2 NA|NA|NA S PFAM Branched-chain amino acid transport system permease component KOPIJCMJ_03224 1120947.ATUX01000005_gene1328 5.4e-72 278.1 Actinobacteria ko:K01989,ko:K05832 M00247 ko00000,ko00002,ko02000 Bacteria 2GKNV@201174,4D55W@85005,COG2984@1,COG2984@2 NA|NA|NA S ABC transporter substrate binding protein KOPIJCMJ_03225 298653.Franean1_0560 1.5e-26 124.8 Frankiales cspC ko:K03704 ko00000,ko03000 Bacteria 2GQRU@201174,4ETAA@85013,COG1278@1,COG1278@2 NA|NA|NA K Cold shock protein KOPIJCMJ_03226 675635.Psed_4066 3.8e-39 167.9 Pseudonocardiales recQ1 Bacteria 2GJ4Y@201174,4E5FD@85010,COG1061@1,COG1061@2,COG3886@1,COG3886@2 NA|NA|NA L Type III restriction enzyme, res subunit KOPIJCMJ_03227 1121017.AUFG01000001_gene2963 5.2e-217 760.4 Intrasporangiaceae ctaD GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 Bacteria 2GJHX@201174,4FF4D@85021,COG0843@1,COG0843@2 NA|NA|NA C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B KOPIJCMJ_03228 351607.Acel_0958 2.8e-24 118.2 Frankiales ctaF GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 2D9MJ@1,2IFFM@201174,32TTI@2,4ETA5@85013 NA|NA|NA C Belongs to the cytochrome c oxidase bacterial subunit CtaF family KOPIJCMJ_03230 469371.Tbis_1298 5.1e-92 344.7 Pseudonocardiales trpD 2.4.2.18,4.1.3.27 ko:K00766,ko:K13497 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R00985,R00986,R01073 RC00010,RC00440,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 Bacteria 2GM4G@201174,4DYFX@85010,COG0547@1,COG0547@2 NA|NA|NA E Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) KOPIJCMJ_03231 196162.Noca_3132 6.1e-46 190.3 Propionibacteriales GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 Bacteria 2II71@201174,4DQR3@85009,COG0784@1,COG0784@2 NA|NA|NA T cheY-homologous receiver domain KOPIJCMJ_03232 1214101.BN159_6284 3.2e-70 271.6 Actinobacteria ctaE GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 iJN678.ctaE Bacteria 2GKK8@201174,COG1845@1,COG1845@2 NA|NA|NA C cytochrome c oxidase, subunit III KOPIJCMJ_03233 1504319.GM45_0765 1.2e-71 276.6 unclassified Actinobacteria (class) qcrC GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K00406,ko:K03889 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00151,M00156 ko00000,ko00001,ko00002 3.D.4.3 Bacteria 2GKUB@201174,3UWHN@52018,COG2010@1,COG2010@2 NA|NA|NA C Cytochrome C oxidase, cbb3-type, subunit III KOPIJCMJ_03234 1504319.GM45_0760 6e-103 380.9 unclassified Actinobacteria (class) qcrA GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K03890,ko:K15878 ko00190,ko01100,map00190,map01100 M00151 ko00000,ko00001,ko00002 iAF987.Gmet_0538 Bacteria 2GIX6@201174,3UWCF@52018,COG0723@1,COG0723@2 NA|NA|NA C Rieske [2Fe-2S] domain KOPIJCMJ_03236 196162.Noca_1249 3.6e-15 87.4 Propionibacteriales 2.1.3.1 ko:K17489 ko00640,map00640 R00353 RC00040 ko00000,ko00001,ko01000 Bacteria 2EJZC@1,2GYHI@201174,33DPX@2,4DW75@85009 NA|NA|NA KOPIJCMJ_03237 196162.Noca_1248 1.1e-236 825.9 Propionibacteriales mmdA 2.1.3.1,2.1.3.15,6.4.1.2,6.4.1.3,6.4.1.4 ko:K01966,ko:K01969,ko:K17489,ko:K18472 ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212 M00036,M00082,M00373,M00741 R00353,R00742,R01859,R04138,R04386 RC00040,RC00097,RC00253,RC00367,RC00609,RC00942 ko00000,ko00001,ko00002,ko01000 iLJ478.TM0716 Bacteria 2GIRU@201174,4DU79@85009,COG4799@1,COG4799@2 NA|NA|NA I Malonate decarboxylase gamma subunit (MdcE) KOPIJCMJ_03238 196162.Noca_1247 2.7e-139 501.9 Propionibacteriales oadA 2.1.3.1,4.1.1.3,6.4.1.1 ko:K01571,ko:K01960,ko:K03416 ko00020,ko00620,ko00640,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00640,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00217,R00344,R00353,R00930 RC00040,RC00097,RC00367 ko00000,ko00001,ko00002,ko01000,ko02000 3.B.1.1.1 iLJ478.TM0128 Bacteria 2IASR@201174,4DWP1@85009,COG5016@1,COG5016@2 NA|NA|NA C Conserved carboxylase domain KOPIJCMJ_03239 1386089.N865_07800 1.2e-131 476.1 Intrasporangiaceae argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 iSBO_1134.SBO_3210,iSbBS512_1146.SbBS512_E3599 Bacteria 2GK96@201174,4FEU3@85021,COG0137@1,COG0137@2 NA|NA|NA E Belongs to the argininosuccinate synthase family. Type 2 subfamily KOPIJCMJ_03240 1123258.AQXZ01000019_gene3032 6.3e-105 387.9 Nocardiaceae Bacteria 2I5AX@201174,4FX6Y@85025,COG0477@1,COG2814@2 NA|NA|NA EGP Major Facilitator Superfamily KOPIJCMJ_03241 446466.Cfla_1316 2.4e-20 106.3 Actinobacteria Bacteria 2ERYQ@1,2GXQP@201174,33JHV@2 NA|NA|NA KOPIJCMJ_03242 1304876.AZVC01000001_gene1260 2.8e-27 128.3 Micrococcaceae Bacteria 1WA7S@1268,2IQEW@201174,COG1725@1,COG1725@2 NA|NA|NA K helix_turn_helix gluconate operon transcriptional repressor KOPIJCMJ_03243 1463901.JOIY01000037_gene7073 7.1e-52 211.1 Actinobacteria Bacteria 2H9P8@201174,COG0697@1,COG0697@2 NA|NA|NA EG spore germination KOPIJCMJ_03244 1108045.GORHZ_141_00770 2.6e-13 80.9 Actinobacteria Bacteria 2EMYX@1,2GZ6D@201174,33FM2@2 NA|NA|NA KOPIJCMJ_03245 1278078.G419_24269 9.9e-63 246.5 Nocardiaceae Bacteria 2GNR0@201174,4FXM7@85025,COG2119@1,COG2119@2 NA|NA|NA S Uncharacterized protein family UPF0016 KOPIJCMJ_03246 1996.JOFO01000054_gene1185 2.4e-55 222.6 Streptosporangiales ko:K07052 ko00000 Bacteria 2GMJ1@201174,4EG7A@85012,COG1266@1,COG1266@2 NA|NA|NA S CAAX protease self-immunity KOPIJCMJ_03247 985054.JQEZ01000003_gene1066 4.5e-31 142.9 Alphaproteobacteria 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUMZ@1224,2TUKX@28211,COG0457@1,COG0457@2,COG5616@1,COG5616@2 NA|NA|NA T Adenylate cyclase KOPIJCMJ_03248 298655.KI912266_gene5611 1.5e-71 276.6 Frankiales ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GN8P@201174,4EV93@85013,COG1131@1,COG1131@2 NA|NA|NA V ABC transporter KOPIJCMJ_03249 471853.Bcav_0362 7.2e-19 101.3 Actinobacteria ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2IRIX@201174,COG1277@1,COG1277@2 NA|NA|NA S ABC-type transport system involved in multi-copper enzyme maturation permease component KOPIJCMJ_03250 1133850.SHJG_5771 5.3e-15 88.2 Actinobacteria Bacteria 2GKW3@201174,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family KOPIJCMJ_03251 292564.Cyagr_1692 4.9e-135 487.6 Cyanobacteria arsB GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015104,GO:0015105,GO:0015291,GO:0015297,GO:0015318,GO:0015698,GO:0015699,GO:0015700,GO:0016020,GO:0022804,GO:0022857,GO:0034220,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656 1.20.4.1 ko:K03325,ko:K03741 ko00000,ko01000,ko02000 2.A.59 iYO844.BSU25790 Bacteria 1G05E@1117,COG0798@1,COG0798@2 NA|NA|NA P PFAM Sodium Bile acid symporter family KOPIJCMJ_03252 1209989.TepiRe1_2456 1.8e-21 108.2 Thermoanaerobacterales Bacteria 1VEYC@1239,24QMF@186801,42H6Q@68295,COG0526@1,COG0526@2 NA|NA|NA CO redox-active disulfide protein 2 KOPIJCMJ_03253 479431.Namu_2554 7.9e-20 102.8 Actinobacteria Bacteria 2GUBI@201174,COG0526@1,COG0526@2 NA|NA|NA CO redox-active disulfide protein 2 KOPIJCMJ_03254 479431.Namu_2555 1.6e-146 525.8 Bacteria ko:K07089 ko00000 Bacteria COG0701@1,COG0701@2 NA|NA|NA S Predicted permease KOPIJCMJ_03255 1304865.JAGF01000001_gene3289 5.2e-20 103.6 Actinobacteria arsR ko:K03892 ko00000,ko03000 Bacteria 2GQU5@201174,COG0640@1,COG0640@2 NA|NA|NA K PFAM regulatory protein, ArsR KOPIJCMJ_03256 1035308.AQYY01000002_gene103 2.9e-24 118.6 Peptococcaceae cdr2 Bacteria 1TPWW@1239,2484C@186801,2606T@186807,COG0446@1,COG0446@2 NA|NA|NA P pyridine nucleotide-disulphide oxidoreductase dimerisation KOPIJCMJ_03257 983917.RGE_15140 5.1e-28 130.2 unclassified Burkholderiales Bacteria 1KJWK@119065,1RFE1@1224,2VHIU@28216,COG2267@1,COG2267@2 NA|NA|NA I Alpha beta hydrolase KOPIJCMJ_03258 196367.JNFG01000009_gene6349 1.6e-113 416.0 Burkholderiaceae yngG GO:0003674,GO:0003824,GO:0004419,GO:0005488,GO:0016829,GO:0016830,GO:0016833,GO:0043167,GO:0043169,GO:0046872 4.1.3.4 ko:K01640 ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146 M00036,M00088 R01360,R08090 RC00502,RC00503,RC01118,RC01946 ko00000,ko00001,ko00002,ko01000 Bacteria 1K3ZG@119060,1MUMX@1224,2VIUW@28216,COG0119@1,COG0119@2 NA|NA|NA E HMGL-like KOPIJCMJ_03259 471852.Tcur_2836 5.9e-254 883.2 Streptosporangiales pyrG GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1276,iECO103_1326.ECO103_3323,iHN637.CLJU_RS01075,iNJ661.Rv1699,iPC815.YPO3377 Bacteria 2GJ13@201174,4EFKB@85012,COG0504@1,COG0504@2 NA|NA|NA F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates KOPIJCMJ_03260 351607.Acel_1242 2.4e-40 172.2 Frankiales nudF 3.6.1.13 ko:K01515 ko00230,map00230 R01054 RC00002 ko00000,ko00001,ko01000 Bacteria 2GNW6@201174,4ESWK@85013,COG0494@1,COG0494@2 NA|NA|NA L PFAM NUDIX hydrolase KOPIJCMJ_03261 219305.MCAG_04961 5.5e-158 563.9 Micromonosporales ald 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 R00396 RC00008 ko00000,ko00001,ko01000 Bacteria 2GJ6G@201174,4DA3S@85008,COG0686@1,COG0686@2 NA|NA|NA C Belongs to the AlaDH PNT family KOPIJCMJ_03262 1120950.KB892767_gene5149 4.2e-103 381.3 Propionibacteriales xerD GO:0008150,GO:0040007 ko:K03733,ko:K04763 ko00000,ko03036 Bacteria 2GNDP@201174,4DNSC@85009,COG4974@1,COG4974@2 NA|NA|NA L tyrosine recombinase KOPIJCMJ_03263 351607.Acel_1240 1.7e-104 386.0 Frankiales soj GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009295,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044464,GO:0071944 ko:K03496 ko00000,ko03036,ko04812 Bacteria 2GJX3@201174,4ERYA@85013,COG1192@1,COG1192@2 NA|NA|NA D PFAM Cobyrinic acid a,c-diamide synthase KOPIJCMJ_03264 1283287.KB822585_gene2646 7.8e-80 303.9 Propionibacteriales scpA ko:K05896 ko00000,ko03036 Bacteria 2GN1U@201174,4DMYR@85009,COG1354@1,COG1354@2 NA|NA|NA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves KOPIJCMJ_03265 420662.Mpe_A1551 1.3e-20 106.3 unclassified Burkholderiales nadB GO:0000166,GO:0001716,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008734,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0015922,GO:0016491,GO:0016638,GO:0016641,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044318,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605 1.3.5.4,1.4.3.16 ko:K00244,ko:K00278 ko00020,ko00190,ko00250,ko00620,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00250,map00620,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00115,M00150,M00173 R00357,R00481,R02164 RC00006,RC00045,RC02566 ko00000,ko00001,ko00002,ko01000 iAF1260.b2574,iBWG_1329.BWG_2338,iECDH10B_1368.ECDH10B_2742,iECDH1ME8569_1439.ECDH1ME8569_2501,iETEC_1333.ETEC_2787,iEcDH1_1363.EcDH1_1094,iJN678.nadB,iJO1366.b2574,iJR904.b2574,iLF82_1304.LF82_1433,iNRG857_1313.NRG857_12785,iSbBS512_1146.nadB,iY75_1357.Y75_RS13445,iYL1228.KPN_02899 Bacteria 1KJXZ@119065,1RBQW@1224,2VHA7@28216,COG0029@1,COG0029@2 NA|NA|NA H Catalyzes the oxidation of L-aspartate to iminoaspartate KOPIJCMJ_03266 1122149.BACN01000019_gene712 1.7e-07 63.2 Lactobacillaceae greA ko:K03624,ko:K04760 ko00000,ko03021 Bacteria 1V1G3@1239,3F6ZK@33958,4HW8H@91061,COG0782@1,COG0782@2 NA|NA|NA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides KOPIJCMJ_03267 644283.Micau_2658 2.6e-129 468.8 Micromonosporales Bacteria 2GRBZ@201174,4DH16@85008,COG3835@1,COG3835@2 NA|NA|NA KT PucR C-terminal helix-turn-helix domain KOPIJCMJ_03268 548479.HMPREF0573_10529 2.6e-08 65.5 Actinobacteria 3.6.3.17 ko:K10441 ko02010,map02010 M00212 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 Bacteria 2GJDV@201174,4D5BM@85005,COG1129@1,COG1129@2 NA|NA|NA G ATPases associated with a variety of cellular activities KOPIJCMJ_03269 710696.Intca_1166 3.3e-15 87.8 Actinobacteria 2.7.1.15 ko:K00852 ko00030,map00030 R01051,R02750 RC00002,RC00017 ko00000,ko00001,ko01000 Bacteria 2GP1C@201174,COG0524@1,COG0524@2 NA|NA|NA G Belongs to the carbohydrate kinase PfkB family KOPIJCMJ_03271 1484479.DI14_14505 7.2e-78 297.4 Bacilli Bacteria 1UFDJ@1239,4HDIH@91061,COG0561@1,COG0561@2 NA|NA|NA G hydrolase # 2702 queries scanned # Total time (seconds): 103.267491817 # Rate: 26.17 q/s