# emapper version: emapper-2.0.1 emapper DB: 2.0 # command: ./emapper.py -m diamond --seed_ortholog_evalue 0.00001 --data_dir /home/bayegy/Databases/emapper/data_dir2.0.1/ --cpu 45 --temp_dir /media/bayegy/disk0/binning_test/Bin_all/emapper//bin.T11.62/_tmp -i /media/bayegy/disk0/binning_test/Bin_all/Bin_prokka//bin.T11.62/bin.T11.62.faa -o /media/bayegy/disk0/binning_test/Bin_all/emapper//bin.T11.62/bin.T11.62 --usemem --override # time: Wed Nov 3 19:08:25 2021 #query_name seed_eggNOG_ortholog seed_ortholog_evalue seed_ortholog_score best_tax_level Preferred_name GOs EC KEGG_ko KEGG_Pathway KEGG_Module KEGG_Reaction KEGG_rclass BRITE KEGG_TC CAZy BiGG_Reaction taxonomic scope eggNOG OGs best eggNOG OG COG Functional cat. eggNOG free text desc. OLIIENHM_00001 931627.MycrhDRAFT_1866 1.5e-187 662.1 Mycobacteriaceae hypD ko:K04654 ko00000 iAF987.Gmet_0117 Bacteria 232GI@1762,2GMHA@201174,COG0409@1,COG0409@2 NA|NA|NA O formation protein HypD OLIIENHM_00002 1440774.Y900_003905 2.9e-35 154.1 Mycobacteriaceae hypC ko:K04653 ko00000 Bacteria 239ZW@1762,2IMSQ@201174,COG0298@1,COG0298@2 NA|NA|NA O Hydrogenase assembly chaperone hypC hupF OLIIENHM_00003 1440774.Y900_003910 8.9e-55 219.9 Mycobacteriaceae hypF GO:0003674,GO:0003824,GO:0005488,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0010467,GO:0016740,GO:0016741,GO:0016743,GO:0019538,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046914,GO:0046944,GO:0051604,GO:0071704,GO:1901564 ko:K04653,ko:K04656 ko00000 iAF987.Gmet_0119 Bacteria 233TX@1762,2GJYF@201174,COG0068@1,COG0068@2 NA|NA|NA O Belongs to the carbamoyltransferase HypF family OLIIENHM_00004 101510.RHA1_ro06823 2.2e-76 291.6 Nocardiaceae sigA GO:0000988,GO:0000990,GO:0001101,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009405,GO:0009415,GO:0009628,GO:0009889,GO:0010035,GO:0010468,GO:0010556,GO:0016020,GO:0016987,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0040007,GO:0042221,GO:0043254,GO:0044087,GO:0044419,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051704,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901700,GO:1903506,GO:2000112,GO:2000142,GO:2001141 ko:K03086,ko:K03087 ko02026,ko05111,map02026,map05111 ko00000,ko00001,ko03021 Bacteria 2GK3Z@201174,4FUYC@85025,COG0568@1,COG0568@2 NA|NA|NA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth OLIIENHM_00006 1288494.EBAPG3_12090 1.8e-23 116.7 Nitrosomonadales Bacteria 1PWB7@1224,2BTJW@1,2WBVY@28216,32NSK@2,373WE@32003 NA|NA|NA OLIIENHM_00007 1150599.MPHLEI_07909 5.6e-38 163.7 Mycobacteriaceae Bacteria 239WM@1762,2GQK6@201174,COG3502@1,COG3502@2 NA|NA|NA S Protein of unknown function (DUF952) OLIIENHM_00008 1440774.Y900_002485 1.9e-23 114.4 Mycobacteriaceae Bacteria 23BD0@1762,2E39Y@1,2GQJA@201174,32Y9G@2 NA|NA|NA OLIIENHM_00009 931627.MycrhDRAFT_6926 6.2e-137 493.8 Mycobacteriaceae ko:K07058 ko00000 Bacteria 233VD@1762,2GM6P@201174,COG1295@1,COG1295@2 NA|NA|NA S ribonuclease BN OLIIENHM_00010 1172186.KB911467_gene2061 2.9e-35 154.1 Mycobacteriaceae Bacteria 23FJE@1762,2CAFG@1,2I800@201174,32ZDZ@2 NA|NA|NA S Protein of unknown function (DUF3039) OLIIENHM_00011 1440774.Y900_002500 5.1e-45 187.2 Mycobacteriaceae Bacteria 23ACG@1762,2EGIC@1,2IFEW@201174,33AAH@2 NA|NA|NA S Protein of unknown function (DUF3099) OLIIENHM_00012 1440774.Y900_002505 5.7e-164 583.6 Mycobacteriaceae sigA GO:0000988,GO:0000990,GO:0001666,GO:0002791,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009410,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010565,GO:0010604,GO:0010628,GO:0016020,GO:0016987,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032879,GO:0032880,GO:0036293,GO:0040007,GO:0042221,GO:0043175,GO:0043254,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050708,GO:0050789,GO:0050794,GO:0050896,GO:0051046,GO:0051049,GO:0051128,GO:0051171,GO:0051173,GO:0051223,GO:0051252,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0070063,GO:0070201,GO:0070482,GO:0071944,GO:0080090,GO:0090087,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:1903530,GO:2000112,GO:2000142,GO:2001141 ko:K03086,ko:K03087 ko02026,ko05111,map02026,map05111 ko00000,ko00001,ko03021 Bacteria 234HS@1762,2GK3Z@201174,COG0568@1,COG0568@2 NA|NA|NA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released OLIIENHM_00013 1440774.Y900_002510 4e-106 391.0 Mycobacteriaceae ideR GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005506,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006355,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0009058,GO:0009237,GO:0009712,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0016151,GO:0018958,GO:0019184,GO:0019219,GO:0019222,GO:0019290,GO:0019540,GO:0019748,GO:0030145,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0034641,GO:0040007,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0044550,GO:0045892,GO:0045934,GO:0046870,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0050897,GO:0051171,GO:0051172,GO:0051186,GO:0051188,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 ko:K03709 ko00000,ko03000 Bacteria 234HW@1762,2GKMC@201174,COG1321@1,COG1321@2 NA|NA|NA K repressor OLIIENHM_00014 1440774.Y900_002515 3.9e-137 494.6 Mycobacteriaceae Bacteria 235FN@1762,2AR9G@1,2GN9V@201174,31GJC@2 NA|NA|NA S Domain of unknown function (DUF4192) OLIIENHM_00015 931627.MycrhDRAFT_2113 2.6e-212 745.0 Mycobacteriaceae sulP GO:0003333,GO:0003674,GO:0005215,GO:0005310,GO:0005326,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0008272,GO:0008509,GO:0008514,GO:0015075,GO:0015103,GO:0015116,GO:0015138,GO:0015141,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015238,GO:0015318,GO:0015556,GO:0015698,GO:0015711,GO:0015740,GO:0015741,GO:0015744,GO:0015800,GO:0015807,GO:0015810,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070778,GO:0071422,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0098656,GO:0098660,GO:0098661,GO:1901682,GO:1902358,GO:1902475,GO:1903825,GO:1905039 ko:K03321 ko00000,ko02000 2.A.53.3 iSbBS512_1146.SbBS512_E1370 Bacteria 234TY@1762,2GJCB@201174,COG0659@1,COG0659@2 NA|NA|NA P Transporter OLIIENHM_00016 1440774.Y900_012415 6.3e-42 176.8 Mycobacteriaceae arsR9 ko:K03892 ko00000,ko03000 Bacteria 239WV@1762,2IKK2@201174,COG0640@1,COG0640@2 NA|NA|NA K transcriptional OLIIENHM_00017 931627.MycrhDRAFT_6934 4.9e-147 527.3 Mycobacteriaceae Bacteria 2342X@1762,2GK8I@201174,COG2047@1,COG2047@2 NA|NA|NA S PAC2 family OLIIENHM_00018 1440774.Y900_002540 3.9e-98 364.4 Mycobacteriaceae phzF Bacteria 234F4@1762,2GMX1@201174,COG0384@1,COG0384@2 NA|NA|NA S Phenazine biosynthesis protein, PhzF family OLIIENHM_00019 216594.MMAR_1994 6.8e-78 296.6 Mycobacteriaceae nrdR GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 ko:K07738 ko00000,ko03000 Bacteria 232W6@1762,2IHU9@201174,COG1327@1,COG1327@2 NA|NA|NA K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes OLIIENHM_00020 1440774.Y900_002550 2.3e-41 175.3 Mycobacteriaceae Bacteria 23A09@1762,2GWI9@201174,COG1388@1,COG1388@2 NA|NA|NA M LysM domain OLIIENHM_00021 258533.BN977_05699 2.6e-94 351.7 Mycobacteriaceae lexA GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0033554,GO:0042221,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045934,GO:0046677,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 3.4.21.88 ko:K01356 M00729 ko00000,ko00002,ko01000,ko01002,ko03400 Bacteria 232J3@1762,2GMBN@201174,COG1974@1,COG1974@2 NA|NA|NA K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair OLIIENHM_00022 1440774.Y900_002560 9.5e-201 706.8 Mycobacteriaceae Bacteria 235PA@1762,2GN2D@201174,COG5479@1,COG5479@2 NA|NA|NA M protein potentially involved in peptidoglycan biosynthesis OLIIENHM_00023 547163.BN979_03137 4.9e-202 710.3 Mycobacteriaceae fadE20 1.3.8.7,1.3.8.8 ko:K00249,ko:K00255 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 Bacteria 232WT@1762,2GM3V@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_00024 931627.MycrhDRAFT_6946 3e-217 761.1 Mycobacteriaceae hflX GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 ko:K03665 ko00000,ko03009 Bacteria 232QH@1762,2GK55@201174,COG2262@1,COG2262@2 NA|NA|NA S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis OLIIENHM_00025 1440774.Y900_002585 9.6e-118 429.9 Mycobacteriaceae dapF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 iIT341.HP0566,iLJ478.TM1522 Bacteria 23364@1762,2GKUD@201174,COG0253@1,COG0253@2 NA|NA|NA E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan OLIIENHM_00026 1440774.Y900_002590 1.2e-126 459.5 Mycobacteriaceae miaA GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006417,GO:0006725,GO:0006807,GO:0006950,GO:0008033,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009451,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016070,GO:0016740,GO:0016765,GO:0019222,GO:0031323,GO:0031326,GO:0032268,GO:0033554,GO:0034248,GO:0034470,GO:0034605,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0043555,GO:0044237,GO:0044238,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0051716,GO:0052381,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1990497,GO:2000112,GO:2000765 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 Bacteria 234WG@1762,2GKFT@201174,COG0324@1,COG0324@2 NA|NA|NA J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) OLIIENHM_00027 931627.MycrhDRAFT_6949 1.2e-78 299.7 Mycobacteriaceae 2.8.4.3 ko:K06168 R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 Bacteria 234QC@1762,2GN3T@201174,COG3885@1,COG3885@2 NA|NA|NA S ferrous iron binding OLIIENHM_00028 164757.Mjls_2147 1.4e-111 409.5 Mycobacteriaceae Bacteria 233PQ@1762,2GRXH@201174,COG0697@1,COG0697@2 NA|NA|NA EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily OLIIENHM_00029 1440774.Y900_002605 2.7e-164 585.1 Mycobacteriaceae Bacteria 2355Q@1762,2GJBD@201174,COG1196@1,COG1196@2 NA|NA|NA D Domain of Unknown Function (DUF349) OLIIENHM_00030 1440774.Y900_002610 2.2e-73 282.0 Mycobacteriaceae Bacteria 238UP@1762,2F4G5@1,2IRZ3@201174,33X67@2 NA|NA|NA OLIIENHM_00031 350058.Mvan_2429 3.2e-241 840.9 Mycobacteriaceae miaB 2.8.4.3 ko:K06168 R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 Bacteria 234KG@1762,2GJEV@201174,COG0621@1,COG0621@2 NA|NA|NA J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine OLIIENHM_00032 1209984.BN978_05034 7.9e-122 443.4 Mycobacteriaceae gluB ko:K10005 ko02010,map02010 M00233 ko00000,ko00001,ko00002,ko02000 3.A.1.3.9 Bacteria 2344R@1762,2GJH8@201174,COG0834@1,COG0834@2 NA|NA|NA ET extracellular solute-binding OLIIENHM_00033 931627.MycrhDRAFT_6495 7.3e-111 406.8 Mycobacteriaceae gluA 3.6.3.21 ko:K02028,ko:K10008 ko02010,map02010 M00233,M00236 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3,3.A.1.3.9 Bacteria 233Q1@1762,2GIZW@201174,COG1126@1,COG1126@2 NA|NA|NA E ABC transporter, ATP-binding protein OLIIENHM_00034 1440774.Y900_002625 1.4e-220 772.3 Mycobacteriaceae gluC GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015318,GO:0015711,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1903825,GO:1905039 ko:K10005,ko:K10006,ko:K10040 ko02010,map02010 M00228,M00233 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.9 Bacteria 2344R@1762,2GJH8@201174,COG0765@1,COG0765@2,COG0834@1,COG0834@2 NA|NA|NA ET extracellular solute-binding OLIIENHM_00035 1440774.Y900_002630 2e-115 422.2 Mycobacteriaceae gluD ko:K02029,ko:K10007 ko02010,map02010 M00233,M00236 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.9 Bacteria 2355N@1762,2GNBH@201174,COG0765@1,COG0765@2 NA|NA|NA P ABC transporter OLIIENHM_00036 1440774.Y900_002680 1.1e-61 243.0 Mycobacteriaceae recX GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03565 ko00000,ko03400 Bacteria 238YB@1762,2GMRF@201174,COG2137@1,COG2137@2 NA|NA|NA S regulatory protein RecX OLIIENHM_00037 1440774.Y900_002685 7.9e-183 646.4 Mycobacteriaceae recA GO:0000150,GO:0000166,GO:0000287,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009650,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0031668,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042148,GO:0042221,GO:0042623,GO:0043142,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 ko:K03553 ko03440,map03440 M00729 ko00000,ko00001,ko00002,ko03400 Bacteria 232KV@1762,2GJ4P@201174,COG0468@1,COG0468@2 NA|NA|NA L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage OLIIENHM_00038 1078020.KEK_16708 1e-24 118.6 Mycobacteriaceae Bacteria 23B6X@1762,2EFU9@1,2GQJW@201174,339KE@2 NA|NA|NA S Protein of unknown function (DUF3046) OLIIENHM_00039 1078020.KEK_16713 4.8e-165 587.4 Mycobacteriaceae Bacteria 234HR@1762,2I8EN@201174,COG1819@1,COG1819@2 NA|NA|NA CG glycosyl transferase OLIIENHM_00040 1440774.Y900_002700 7.6e-55 219.9 Mycobacteriaceae ephG GO:0003674,GO:0003824,GO:0004301,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016801,GO:0016803,GO:0018904,GO:0033963,GO:0044237,GO:0044281,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0097176,GO:1901360 3.3.2.8 ko:K10533 ko00903,map00903 R05784,R09387 RC01473,RC02519 ko00000,ko00001,ko01000 Bacteria 23946@1762,2IN4A@201174,COG4308@1,COG4308@2 NA|NA|NA Q Limonene-1,2-epoxide hydrolase OLIIENHM_00041 931627.MycrhDRAFT_6450 1.1e-104 386.3 Mycobacteriaceae Bacteria 233DV@1762,2FK8T@1,2H0B8@201174,34BWG@2 NA|NA|NA OLIIENHM_00042 700508.D174_11790 8.8e-118 429.9 Mycobacteriaceae pspA GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044464,GO:0071944 ko:K03969 ko00000 Bacteria 232R0@1762,2GJGD@201174,COG1842@1,COG1842@2 NA|NA|NA KT phage shock protein a (IM30), suppresses OLIIENHM_00045 931627.MycrhDRAFT_5839 1e-65 256.1 Mycobacteriaceae 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 Bacteria 238M8@1762,2IFZV@201174,COG3832@1,COG3832@2 NA|NA|NA S polyketide cyclase dehydrase OLIIENHM_00046 710685.MycrhN_3480 3.8e-114 418.3 Mycobacteriaceae 3.4.16.4 ko:K01286 ko00000,ko01000 Bacteria 2362T@1762,2GIX5@201174,COG1680@1,COG1680@2 NA|NA|NA V beta-lactamase OLIIENHM_00047 1440774.Y900_025625 4.2e-36 157.5 Mycobacteriaceae Bacteria 23A1V@1762,2ISYE@201174,COG3832@1,COG3832@2 NA|NA|NA S polyketide cyclase OLIIENHM_00048 931627.MycrhDRAFT_5843 1.2e-49 203.0 Mycobacteriaceae aroQ GO:0003674,GO:0003824,GO:0004106,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005623,GO:0006082,GO:0006520,GO:0006558,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0042597,GO:0042802,GO:0042803,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046417,GO:0046983,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 4.2.1.51,5.4.99.5 ko:K04093,ko:K04518 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715 RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 Bacteria 2397C@1762,2IEAG@201174,COG1605@1,COG1605@2 NA|NA|NA M Catalyzes the Claisen rearrangement of chorismate to prephenate OLIIENHM_00049 931627.MycrhDRAFT_5845 4.7e-130 471.1 Mycobacteriaceae pepA ko:K08372 ko02020,map02020 ko00000,ko00001,ko01000,ko01002 Bacteria 2356N@1762,2GJJ3@201174,COG0265@1,COG0265@2 NA|NA|NA M serine protease OLIIENHM_00050 931627.MycrhDRAFT_5849 6.1e-49 200.7 Mycobacteriaceae lppJ GO:0005575,GO:0005576 Bacteria 239I2@1762,29IV3@1,2IRSB@201174,305SF@2 NA|NA|NA OLIIENHM_00051 931627.MycrhDRAFT_5850 5.3e-48 196.8 Mycobacteriaceae fdxA GO:0001666,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0009605,GO:0009607,GO:0009628,GO:0036293,GO:0043207,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0070482,GO:0075136 ko:K05524 ko00000 Bacteria 23A6Z@1762,2IKVN@201174,COG1146@1,COG1146@2 NA|NA|NA C ferredoxin OLIIENHM_00052 557599.MKAN_00045 7.2e-43 179.9 Mycobacteriaceae 3.1.1.24,4.1.1.44 ko:K01607,ko:K04756,ko:K14727 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00568 R02991,R03470 RC00825,RC00938 ko00000,ko00001,ko00002,ko01000 Bacteria 239WZ@1762,2IRPW@201174,COG0599@1,COG0599@2 NA|NA|NA O Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity OLIIENHM_00053 1440774.Y900_025685 5.3e-96 357.5 Mycobacteriaceae lppS Bacteria 232SN@1762,2GP9J@201174,COG1376@1,COG1376@2 NA|NA|NA S ErfK YbiS YcfS YnhG family protein OLIIENHM_00054 931627.MycrhDRAFT_5855 9.5e-63 246.5 Mycobacteriaceae Bacteria 238Q2@1762,2IG0K@201174,COG2353@1,COG2353@2 NA|NA|NA S Belongs to the UPF0312 family OLIIENHM_00055 1440774.Y900_025740 1.9e-32 146.0 Mycobacteriaceae Bacteria 235T7@1762,2IDE5@201174,COG0515@1,COG0515@2 NA|NA|NA KLT serine threonine protein kinase OLIIENHM_00056 931627.MycrhDRAFT_5866 8.7e-89 333.6 Mycobacteriaceae ko:K22010 M00839 ko00000,ko00002,ko02022 Bacteria 237DW@1762,2I8U9@201174,COG3707@1,COG3707@2 NA|NA|NA K ANTAR OLIIENHM_00057 1440774.Y900_025755 1.4e-26 125.6 Mycobacteriaceae Bacteria 23B38@1762,2GPF4@201174,COG1366@1,COG1366@2 NA|NA|NA T STAS domain OLIIENHM_00058 1123023.JIAI01000010_gene8689 7.9e-36 157.9 Pseudonocardiales Bacteria 2GK8P@201174,4DY1K@85010,COG0642@1,COG0745@1,COG0745@2,COG2205@2,COG2208@1,COG2208@2 NA|NA|NA T PhoQ Sensor OLIIENHM_00059 931627.MycrhDRAFT_5869 4.4e-58 230.7 Mycobacteriaceae Bacteria 239A0@1762,2ASSI@1,2IHP2@201174,31I7P@2 NA|NA|NA OLIIENHM_00060 1370125.AUWT01000003_gene4317 6.5e-191 673.3 Mycobacteriaceae Bacteria 232ZV@1762,2GKGT@201174,COG2070@1,COG2070@2 NA|NA|NA S 2-nitropropane dioxygenase OLIIENHM_00061 318424.EU78_13625 3.3e-32 144.4 Mycobacteriaceae Bacteria 23A2X@1762,2IQI4@201174,COG1917@1,COG1917@2 NA|NA|NA S Cupin domain OLIIENHM_00062 1184609.KILIM_022_00220 2.1e-187 661.8 Dermatophilaceae hmp GO:0000041,GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0004155,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006826,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008289,GO:0008941,GO:0009056,GO:0009987,GO:0015669,GO:0015671,GO:0015893,GO:0016491,GO:0016645,GO:0016646,GO:0016667,GO:0016671,GO:0016705,GO:0016708,GO:0017144,GO:0019725,GO:0019825,GO:0020037,GO:0030001,GO:0030003,GO:0031406,GO:0032843,GO:0033293,GO:0033554,GO:0034641,GO:0036094,GO:0042133,GO:0042135,GO:0042221,GO:0042493,GO:0042592,GO:0042737,GO:0043167,GO:0043168,GO:0043177,GO:0044237,GO:0044248,GO:0044270,GO:0044424,GO:0044464,GO:0046209,GO:0046210,GO:0046906,GO:0046916,GO:0048037,GO:0048878,GO:0050660,GO:0050662,GO:0050801,GO:0050896,GO:0051179,GO:0051213,GO:0051234,GO:0051409,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0071500,GO:0071949,GO:0072593,GO:0097159,GO:0098771,GO:1901265,GO:1901363,GO:2001057 1.14.12.17 ko:K05916,ko:K06886 ko05132,map05132 ko00000,ko00001,ko01000 iECP_1309.ECP_2554 Bacteria 2GKXT@201174,4F67A@85018,COG1017@1,COG1017@2,COG1018@1,COG1018@2 NA|NA|NA C Globin OLIIENHM_00063 710685.MycrhN_0166 1.7e-41 175.3 Mycobacteriaceae yeaO Bacteria 23A9X@1762,2IQC0@201174,COG3189@1,COG3189@2 NA|NA|NA S Protein of unknown function, DUF488 OLIIENHM_00064 1440774.Y900_027860 6.7e-71 275.0 Mycobacteriaceae Bacteria 237ZC@1762,2GK45@201174,COG3391@1,COG3391@2 NA|NA|NA S TIGRFAM 40-residue YVTN family beta-propeller repeat OLIIENHM_00065 1121927.GOHSU_48_00050 4.2e-11 73.6 Gordoniaceae ko:K03321 ko00000,ko02000 2.A.53.3 Bacteria 2GJCB@201174,4GB1N@85026,COG0659@1,COG0659@2 NA|NA|NA P Sulfate permease family OLIIENHM_00066 525368.HMPREF0591_0181 2e-215 755.0 Mycobacteriaceae Bacteria 237AM@1762,2GNUD@201174,COG4584@1,COG4584@2 NA|NA|NA L DNA-dependent DNA replication OLIIENHM_00067 1078020.KEK_06725 8.5e-86 323.2 Mycobacteriaceae Bacteria 236ZS@1762,2H714@201174,COG1484@1,COG1484@2 NA|NA|NA L IstB-like ATP binding protein OLIIENHM_00068 525368.HMPREF0591_1896 1.1e-14 84.7 Mycobacteriaceae Bacteria 236ZS@1762,2H714@201174,COG1484@1,COG1484@2 NA|NA|NA L IstB-like ATP binding protein OLIIENHM_00069 1268303.RHODMAR_0464 6e-25 120.2 Nocardiaceae ko:K03321 ko00000,ko02000 2.A.53.3 Bacteria 2GJCB@201174,4FVK9@85025,COG0659@1,COG0659@2 NA|NA|NA P Sulfate permease family OLIIENHM_00070 1121035.AUCH01000002_gene1645 1.1e-95 357.5 Betaproteobacteria Bacteria 1N58G@1224,2VYA2@28216,COG0471@1,COG0471@2 NA|NA|NA P Sodium:sulfate symporter transmembrane region OLIIENHM_00071 1121035.AUCH01000002_gene1644 1e-49 204.1 Betaproteobacteria Bacteria 1PEQ1@1224,2W4ER@28216,COG2984@1,COG2984@2 NA|NA|NA S ABC transporter substrate binding protein OLIIENHM_00072 1298864.AUEQ01000011_gene235 3.6e-55 220.7 Mycobacteriaceae Bacteria 239CS@1762,2IHTG@201174,COG0346@1,COG0346@2 NA|NA|NA E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily OLIIENHM_00073 1440774.Y900_023170 2.6e-49 201.4 Mycobacteriaceae Z012_09115 ko:K15977 ko00000 Bacteria 239XU@1762,2IIEU@201174,COG2259@1,COG2259@2 NA|NA|NA S membrane OLIIENHM_00074 1380386.JIAW01000001_gene4503 4.1e-280 970.3 Mycobacteriaceae acd 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 Bacteria 233JI@1762,2GJIB@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_00075 258533.BN977_06202 4.8e-202 710.7 Mycobacteriaceae Bacteria 236JQ@1762,2GJ1D@201174,COG0531@1,COG0531@2 NA|NA|NA E Amino acid permease OLIIENHM_00076 931627.MycrhDRAFT_1757 2.7e-208 731.5 Mycobacteriaceae nia Bacteria 2335B@1762,2GMG2@201174,COG2041@1,COG2041@2 NA|NA|NA S Oxidoreductase OLIIENHM_00077 258533.BN977_03115 1.1e-08 66.6 Mycobacteriaceae Bacteria 23A4W@1762,2AWI9@1,2IPHA@201174,31NEU@2 NA|NA|NA OLIIENHM_00078 931627.MycrhDRAFT_2198 6e-93 347.1 Mycobacteriaceae ddpX 3.4.13.22 ko:K08641 ko01502,ko02020,map01502,map02020 M00651 ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504 Bacteria 2377B@1762,2GNX8@201174,COG3786@1,COG3786@2 NA|NA|NA S PFAM L,D-transpeptidase catalytic domain OLIIENHM_00079 1229780.BN381_310092 1.8e-110 405.6 Bacteria 2.7.4.1 ko:K22468 ko00190,ko03018,map00190,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria COG2326@1,COG2326@2 NA|NA|NA S polyphosphate kinase activity OLIIENHM_00080 479431.Namu_3507 4.9e-47 194.5 Actinobacteria ko:K07220 ko00000 Bacteria 2IIE4@201174,COG1392@1,COG1392@2 NA|NA|NA P Protein of unknown function DUF47 OLIIENHM_00081 1123258.AQXZ01000016_gene2438 9e-91 340.5 Nocardiaceae ko:K03306 ko00000 2.A.20 Bacteria 2GJHK@201174,4FW14@85025,COG0306@1,COG0306@2 NA|NA|NA P Phosphate transporter family OLIIENHM_00082 1121926.AXWO01000003_gene773 5.8e-18 98.6 Glycomycetales XK27_10720 Bacteria 2GKR5@201174,4EY92@85014,COG2339@1,COG2339@2 NA|NA|NA S Protease prsW family OLIIENHM_00083 1440774.Y900_025640 9.7e-162 576.2 Mycobacteriaceae Bacteria 234E3@1762,2DB7W@1,2GP9W@201174,2Z7P1@2 NA|NA|NA S Domain of unknown function (DUF4331) OLIIENHM_00085 710687.KI912270_gene6482 1.7e-38 165.6 Bacteria Bacteria COG3409@1,COG3409@2 NA|NA|NA M Peptidoglycan-binding domain 1 protein OLIIENHM_00086 232348.ADXL01000034_gene1401 1.1e-60 240.0 Synechococcus Bacteria 1G7KV@1117,1H0AY@1129,COG0500@1,COG2226@2 NA|NA|NA Q Methyltransferase domain OLIIENHM_00087 1298864.AUEQ01000011_gene268 9.3e-185 653.3 Mycobacteriaceae mhpA 1.14.13.127 ko:K05712 ko00360,ko01120,ko01220,map00360,map01120,map01220 M00545 R06786,R06787 RC00236 ko00000,ko00001,ko00002,ko01000 Bacteria 233W1@1762,2GK88@201174,COG0654@1,COG0654@2 NA|NA|NA CH FAD binding domain OLIIENHM_00088 350058.Mvan_4907 9.3e-135 486.5 Mycobacteriaceae 3.7.1.2 ko:K16171 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R01364 RC00326,RC00446 ko00000,ko00001,ko00002,ko01000 Bacteria 2334T@1762,2GM9G@201174,COG0179@1,COG0179@2 NA|NA|NA Q fumarylacetoacetate (FAA) hydrolase OLIIENHM_00089 44454.NF84_08070 5.5e-166 590.5 Mycobacteriaceae bphC_1 Bacteria 235DQ@1762,2GN2E@201174,COG0346@1,COG0346@2 NA|NA|NA E Glyoxalase bleomycin resistance protein dioxygenase OLIIENHM_00090 37919.EP51_20085 3.6e-74 285.0 Nocardiaceae Bacteria 2GJ7Z@201174,4FWDA@85025,COG1024@1,COG1024@2 NA|NA|NA I Belongs to the enoyl-CoA hydratase isomerase family OLIIENHM_00091 1449048.JQKU01000006_gene5160 6e-144 517.3 Mycobacteriaceae Bacteria 237K9@1762,2I5JQ@201174,COG1960@1,COG1960@2 NA|NA|NA I PFAM Acyl-CoA oxidase dehydrogenase, type 1 OLIIENHM_00092 419947.MRA_0064 1.1e-130 473.0 Mycobacteriaceae celA 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 R06200,R11307,R11308 ko00000,ko00001,ko01000 GH5,GH9 Bacteria 233YT@1762,2GK39@201174,COG5297@1,COG5297@2 NA|NA|NA G Belongs to the glycosyl hydrolase family 6 OLIIENHM_00093 931627.MycrhDRAFT_2082 5.1e-74 285.0 Mycobacteriaceae Bacteria 232GB@1762,2GMIX@201174,COG2339@1,COG2339@2 NA|NA|NA S peptidase activity OLIIENHM_00094 1440774.Y900_012540 2e-185 655.6 Mycobacteriaceae ko:K08677 ko00000,ko01002 Bacteria 23C7Q@1762,2GMZ8@201174,COG4934@1,COG4934@2 NA|NA|NA O Peptidase S53 OLIIENHM_00095 931627.MycrhDRAFT_2156 3.6e-64 251.5 Mycobacteriaceae Bacteria 23CU8@1762,2B754@1,2H3NG@201174,3206M@2 NA|NA|NA OLIIENHM_00096 1265310.CCBD010000070_gene233 9.7e-128 463.0 Mycobacteriaceae 1.1.1.105 ko:K07124,ko:K15734 ko00830,map00830 R02124 RC00649 ko00000,ko00001,ko01000 Bacteria 23C93@1762,2IAR1@201174,COG0300@1,COG0300@2 NA|NA|NA S KR domain OLIIENHM_00097 164757.Mjls_4427 4e-168 597.8 Mycobacteriaceae clcA ko:K03281 ko00000 2.A.49 Bacteria 2351T@1762,2GPPN@201174,COG0038@1,COG0038@2 NA|NA|NA P Chloride channel OLIIENHM_00098 931627.MycrhDRAFT_2049 2.3e-177 628.6 Mycobacteriaceae ko:K03294,ko:K03758 ko00000,ko02000 2.A.3.2 Bacteria 23D1J@1762,2H2J4@201174,COG0531@1,COG0531@2 NA|NA|NA E Amino acid permease OLIIENHM_00099 931627.MycrhDRAFT_4920 3.9e-228 797.3 Mycobacteriaceae 1.14.13.22 ko:K03379 ko00930,ko01120,ko01220,map00930,map01120,map01220 R02231,R06622 RC00662,RC01550 ko00000,ko00001,ko01000 Bacteria 232CF@1762,2GMD5@201174,COG2072@1,COG2072@2 NA|NA|NA P flavoprotein involved in K transport OLIIENHM_00100 931627.MycrhDRAFT_5164 1.6e-38 167.2 Mycobacteriaceae Bacteria 23CSQ@1762,2B6RK@1,2H2H1@201174,31ZQJ@2 NA|NA|NA OLIIENHM_00101 1380386.JIAW01000002_gene5790 7.3e-167 593.6 Mycobacteriaceae nhaP Bacteria 2382N@1762,2I37Q@201174,COG0025@1,COG0025@2 NA|NA|NA P antiporters are ubiquitous membrane proteins that are involved in homeostasis of H( ) and na( ) throughout the biological kingdom OLIIENHM_00102 1370121.AUWS01000073_gene951 6.8e-55 220.3 Mycobacteriaceae Bacteria 236X4@1762,2IHUG@201174,COG1876@1,COG1876@2 NA|NA|NA M Peptidase M15B and M15C, D,D-carboxypeptidase VanY OLIIENHM_00103 318424.EU78_04395 1.9e-121 441.8 Mycobacteriaceae yjbH Bacteria 2359N@1762,2H7YD@201174,COG2761@1,COG2761@2 NA|NA|NA Q DSBA-like thioredoxin domain OLIIENHM_00104 1194972.MVAC_23445 1.2e-224 785.8 Actinobacteria ulaA 2.7.1.194 ko:K02822,ko:K03475 ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060 M00283,M00550 R07671 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.7.1 Bacteria 2GMYV@201174,COG3037@1,COG3037@2 NA|NA|NA G sugar-specific permease SgaT UlaA OLIIENHM_00105 1194972.MVAC_23450 3.8e-94 351.3 Actinobacteria ulaC 2.7.1.194,2.7.1.197,2.7.1.202 ko:K02768,ko:K02769,ko:K02770,ko:K02798,ko:K02821,ko:K02822 ko00051,ko00053,ko01100,ko01120,ko02060,map00051,map00053,map01100,map01120,map02060 M00273,M00274,M00283,M00550 R02704,R03232,R07671 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1,4.A.2.1.12,4.A.2.1.2,4.A.2.1.24,4.A.2.1.5,4.A.7.1 Bacteria 2I8CH@201174,COG1762@1,COG1762@2,COG3414@1,COG3414@2 NA|NA|NA G phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 OLIIENHM_00106 1341646.CBMO010000093_gene5738 3.7e-161 574.3 Mycobacteriaceae Bacteria 2335G@1762,2GKPX@201174,COG2141@1,COG2141@2 NA|NA|NA C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases OLIIENHM_00107 710686.Mycsm_01482 1.8e-154 552.4 Mycobacteriaceae cax GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015085,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015368,GO:0015369,GO:0015491,GO:0015672,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051139,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:0099516,GO:1902600 ko:K07300 ko00000,ko02000 2.A.19 iJN678.slr1336 Bacteria 234QT@1762,2IA57@201174,COG0387@1,COG0387@2 NA|NA|NA P Sodium/calcium exchanger protein OLIIENHM_00108 1078020.KEK_10998 3.6e-85 321.2 Mycobacteriaceae Bacteria 234HC@1762,2GJ38@201174,COG2356@1,COG2356@2 NA|NA|NA L Protein of unknown function (DUF1524) OLIIENHM_00109 28072.Nos7524_2967 1.5e-23 117.5 Nostocales phy 3.1.3.1,3.1.3.8 ko:K01077,ko:K01083,ko:K01113,ko:K07093 ko00562,ko00730,ko00790,ko01100,ko02020,map00562,map00730,map00790,map01100,map02020 M00126 R02135,R03371,R04620 RC00017,RC00078 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 Bacteria 1G00S@1117,1HIY4@1161,COG4222@1,COG4222@2,COG4247@1,COG4247@2 NA|NA|NA I 3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase) OLIIENHM_00110 164757.Mjls_2701 2.6e-163 582.4 Mycobacteriaceae Bacteria 233HH@1762,2GKYI@201174,COG4409@1,COG4409@2 NA|NA|NA G Domain of unknown function (DUF4185) OLIIENHM_00111 557599.MKAN_13950 5.1e-34 150.6 Mycobacteriaceae MA20_19855 Bacteria 2397K@1762,2IHRM@201174,COG3631@1,COG3631@2 NA|NA|NA S SnoaL-like domain OLIIENHM_00112 1078020.KEK_05737 6.8e-51 206.8 Mycobacteriaceae Bacteria 238UK@1762,2ARRN@1,2IG68@201174,31H2R@2 NA|NA|NA S Domain of unknown function (DUF5078) OLIIENHM_00113 710686.Mycsm_03151 0.0 1286.9 Mycobacteriaceae ko:K06994 ko00000 Bacteria 232PC@1762,2GKX6@201174,COG2409@1,COG2409@2 NA|NA|NA S transport protein OLIIENHM_00114 875328.JDM601_2080 1.8e-32 145.2 Mycobacteriaceae GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 Bacteria 23AK0@1762,2A2PD@1,2IQCY@201174,30R22@2 NA|NA|NA S Protein of unknown function (DUF732) OLIIENHM_00115 931627.MycrhDRAFT_4201 5.5e-106 390.6 Mycobacteriaceae Bacteria 232S4@1762,2GMQE@201174,COG1028@1,COG1028@2 NA|NA|NA IQ KR domain OLIIENHM_00117 164757.Mjls_5453 1.1e-124 453.4 Mycobacteriaceae idsA 2.5.1.1,2.5.1.10,2.5.1.29 ko:K13787 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00365 R01658,R02003,R02061 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 Bacteria 2368H@1762,2GJEK@201174,COG0142@1,COG0142@2 NA|NA|NA H Belongs to the FPP GGPP synthase family OLIIENHM_00118 931627.MycrhDRAFT_4199 5.8e-227 793.5 Mycobacteriaceae crtI 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 ko:K10027 ko00906,ko01100,ko01110,map00906,map01100,map01110 R04787,R04798,R04800,R09691,R09692 RC01214,RC02088,RC02605 ko00000,ko00001,ko01000 Bacteria 232ZW@1762,2GJAV@201174,COG1233@1,COG1233@2 NA|NA|NA Q phytoene OLIIENHM_00119 931627.MycrhDRAFT_4198 2.6e-129 468.4 Mycobacteriaceae crtB GO:0003674,GO:0003824,GO:0004337,GO:0004659,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016108,GO:0016109,GO:0016114,GO:0016116,GO:0016117,GO:0016740,GO:0016765,GO:0016767,GO:0042440,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046148,GO:0071704,GO:1901576 2.5.1.21,2.5.1.32,2.5.1.96,2.5.1.99 ko:K00801,ko:K02291,ko:K10208 ko00100,ko00906,ko00909,ko01062,ko01100,ko01110,ko01130,map00100,map00906,map00909,map01062,map01100,map01110,map01130 M00097 R00702,R02065,R02872,R04218,R06223,R07270,R07652,R09793,R10177 RC00362,RC00796,RC01101,RC02839,RC02869 ko00000,ko00001,ko00002,ko01000,ko01006 Bacteria 232EI@1762,2GJN2@201174,COG1562@1,COG1562@2 NA|NA|NA I Phytoene synthase OLIIENHM_00120 931627.MycrhDRAFT_4197 3.5e-34 151.0 Mycobacteriaceae crtYc Bacteria 23FJP@1762,2IQR4@201174,33310@2,arCOG05416@1 NA|NA|NA S lycopene cyclase domain OLIIENHM_00121 1370125.AUWT01000053_gene3039 1.6e-43 181.8 Mycobacteriaceae crtYd Bacteria 23A2U@1762,2E9MI@1,2IMX9@201174,333U6@2 NA|NA|NA S lycopene cyclase OLIIENHM_00122 1440774.Y900_022765 7.7e-116 423.3 Mycobacteriaceae crtT Bacteria 234FT@1762,2HFM8@201174,COG0500@1,COG2226@2 NA|NA|NA Q Methyltransferase OLIIENHM_00123 931627.MycrhDRAFT_4194 1.1e-220 772.7 Mycobacteriaceae crtU ko:K09879 ko00906,map00906 R07541,R07560,R07857,R07858 RC01901,RC01965 ko00000,ko00001 Bacteria 234PK@1762,2GITE@201174,COG3349@1,COG3349@2 NA|NA|NA Q amine oxidase OLIIENHM_00124 1440774.Y900_022775 1e-147 529.6 Mycobacteriaceae crtV ko:K09879 ko00906,map00906 R07541,R07560,R07857,R07858 RC01901,RC01965 ko00000,ko00001 Bacteria 232D0@1762,2I2DT@201174,COG4638@1,COG4638@2 NA|NA|NA P Rieske 2Fe-2S OLIIENHM_00125 350058.Mvan_3771 9.5e-184 649.4 Mycobacteriaceae dapB_3 1.4.1.12,1.4.1.26 ko:K21672 ko00310,ko00330,ko00472,map00310,map00330,map00472 R02825,R04200,R04201,R04687,R04688 RC00249,RC00790 ko00000,ko00001,ko01000 Bacteria 23455@1762,2I8GH@201174,COG3804@1,COG3804@2 NA|NA|NA S dihydrodipicolinate reductase OLIIENHM_00126 931627.MycrhDRAFT_4191 9.5e-77 294.3 Mycobacteriaceae Bacteria 232QM@1762,2GNTE@201174,COG0443@1,COG0443@2 NA|NA|NA O Molecular chaperone OLIIENHM_00127 1440774.Y900_022800 4.7e-122 444.5 Mycobacteriaceae crtF 2.1.1.210,2.1.1.281,2.1.1.79 ko:K00574,ko:K09846,ko:K21192,ko:K21457 ko00906,ko01059,ko01100,ko01130,map00906,map01059,map01100,map01130 M00829 R07521,R07524,R07527,R07529,R07533,R07535,R11371 RC00003,RC00332,RC02082 ko00000,ko00001,ko00002,ko01000 Bacteria 232ES@1762,2GKD3@201174,COG2230@1,COG2230@2 NA|NA|NA M SAM dependent carboxyl methyltransferase OLIIENHM_00128 1440774.Y900_022805 2e-22 111.3 Mycobacteriaceae Bacteria 23BFQ@1762,2DRVI@1,2GXN0@201174,33D91@2 NA|NA|NA OLIIENHM_00129 1299327.I546_3560 1e-53 216.9 Mycobacteriaceae Bacteria 236UA@1762,291KP@1,2I8UB@201174,2ZP70@2 NA|NA|NA OLIIENHM_00130 318424.EU78_26430 1.9e-161 575.5 Mycobacteriaceae MA20_17025 Bacteria 233C1@1762,2GKC7@201174,COG1063@1,COG1063@2 NA|NA|NA E Dehydrogenase OLIIENHM_00131 931627.MycrhDRAFT_4184 9.5e-99 366.3 Mycobacteriaceae Bacteria 232XG@1762,2GJ7I@201174,COG0491@1,COG0491@2 NA|NA|NA S Metallo-beta-lactamase superfamily OLIIENHM_00132 931627.MycrhDRAFT_4183 1.1e-192 679.1 Mycobacteriaceae adhE2 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.1.1.306 ko:K00153 R09129,R10301 RC00069,RC01715 ko00000,ko01000 Bacteria 235BD@1762,2GM8C@201174,COG1062@1,COG1062@2 NA|NA|NA C alcohol dehydrogenase OLIIENHM_00133 1313172.YM304_41460 1.6e-102 379.4 Actinobacteria yedI GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K09781 ko00000 Bacteria 2GM9S@201174,COG2354@1,COG2354@2 NA|NA|NA S protein conserved in bacteria OLIIENHM_00134 1122247.C731_2728 5.9e-117 427.2 Mycobacteriaceae bla Bacteria 233K7@1762,2GNVX@201174,COG1680@1,COG1680@2 NA|NA|NA V beta-lactamase OLIIENHM_00135 931627.MycrhDRAFT_4179 8.5e-90 336.3 Mycobacteriaceae Bacteria 23393@1762,299E4@1,2GM90@201174,2ZWGX@2 NA|NA|NA S Protein of unknown function (DUF3145) OLIIENHM_00136 1209984.BN978_03062 4.6e-185 654.1 Mycobacteriaceae Bacteria 2355T@1762,2I2FE@201174,COG2267@1,COG2267@2 NA|NA|NA I Secretory lipase OLIIENHM_00137 419947.MRA_2114 3.8e-159 568.2 Mycobacteriaceae GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 Bacteria 232ST@1762,2GP2N@201174,COG1403@1,COG1403@2 NA|NA|NA V HNH endonuclease OLIIENHM_00138 1440774.Y900_022850 7.4e-134 483.4 Mycobacteriaceae dagK GO:0003674,GO:0003824,GO:0004143,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.1.107 ko:K07029 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 R02240 RC00002,RC00017 ko00000,ko00001,ko01000 Bacteria 234RE@1762,2GK3P@201174,COG1597@1,COG1597@2 NA|NA|NA I Diacylglycerol kinase OLIIENHM_00139 931627.MycrhDRAFT_4173 3.1e-239 834.3 Mycobacteriaceae eapA 2.5.1.26 ko:K00803,ko:K11472 ko00565,ko00630,ko01100,ko01110,ko01120,ko01130,ko04146,map00565,map00630,map01100,map01110,map01120,map01130,map04146 R00475,R04311 RC00020,RC00042,RC02886 ko00000,ko00001,ko01000 Bacteria 232UQ@1762,2GIS6@201174,COG0277@1,COG0277@2 NA|NA|NA C FAD linked OLIIENHM_00140 1440774.Y900_022860 2.8e-73 281.6 Mycobacteriaceae GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141 Bacteria 233AD@1762,2IM3P@201174,COG1309@1,COG1309@2 NA|NA|NA K Transcriptional regulator OLIIENHM_00141 1440774.Y900_022865 1.7e-218 765.4 Mycobacteriaceae glpD GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 R00848 RC00029 ko00000,ko00001,ko01000 Bacteria 234IA@1762,2GJKN@201174,COG0578@1,COG0578@2 NA|NA|NA C Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family OLIIENHM_00142 931627.MycrhDRAFT_4168 3e-249 867.5 Mycobacteriaceae accD6 GO:0003674,GO:0003824,GO:0003989,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009056,GO:0009058,GO:0009062,GO:0009317,GO:0009987,GO:0016042,GO:0016053,GO:0016054,GO:0016421,GO:0016874,GO:0016885,GO:0019367,GO:0019752,GO:0030312,GO:0030497,GO:0032787,GO:0032991,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0071704,GO:0071944,GO:0072329,GO:0072330,GO:1901575,GO:1901576,GO:1902494 2.1.3.15,6.4.1.2,6.4.1.3 ko:K18472 ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00741 R00742,R01859,R04386 RC00040,RC00097,RC00253,RC00367,RC00609 ko00000,ko00001,ko00002,ko01000 Bacteria 232Y6@1762,2I16G@201174,COG4799@1,COG4799@2 NA|NA|NA I propionyl-CoA carboxylase OLIIENHM_00143 1120797.KB908256_gene2022 4.3e-204 717.2 Mycobacteriaceae fabF 2.3.1.179 ko:K09458,ko:K11609 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 232XH@1762,2GIY4@201174,COG0304@1,COG0304@2 NA|NA|NA IQ Belongs to the beta-ketoacyl-ACP synthases family OLIIENHM_00144 1150599.MPHLEI_00340 8.2e-211 739.6 Mycobacteriaceae kasA GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019367,GO:0019752,GO:0030312,GO:0030497,GO:0032787,GO:0040007,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:0072330,GO:1901576 2.3.1.179 ko:K09458,ko:K11609 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 2345I@1762,2GIY4@201174,COG0304@1,COG0304@2 NA|NA|NA IQ Belongs to the beta-ketoacyl-ACP synthases family OLIIENHM_00145 1440774.Y900_022885 1.7e-42 178.3 Mycobacteriaceae acpP GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006633,GO:0006637,GO:0006643,GO:0006644,GO:0006664,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009150,GO:0009245,GO:0009247,GO:0009259,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016053,GO:0019637,GO:0019693,GO:0019752,GO:0019842,GO:0030312,GO:0031177,GO:0032787,GO:0033218,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046483,GO:0046493,GO:0048037,GO:0051186,GO:0051192,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072341,GO:0072521,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901360,GO:1901564,GO:1901576,GO:1903509 ko:K02078 ko00000,ko00001 Bacteria 239ZG@1762,2IQ43@201174,COG0236@1,COG0236@2 NA|NA|NA IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis OLIIENHM_00146 1370121.AUWS01000076_gene645 3.7e-128 464.5 Mycobacteriaceae fabD GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005835,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.180,2.3.1.39 ko:K00645,ko:K00648 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082,M00083 R01626,R10707,R11671 RC00004,RC00039,RC02727,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 232EA@1762,2GME0@201174,COG0331@1,COG0331@2 NA|NA|NA I malonyltransferase activity OLIIENHM_00147 1440774.Y900_022895 1.2e-185 656.0 Mycobacteriaceae GO:0008150,GO:0040007 Bacteria 233CX@1762,2I2QR@201174,COG3835@1,COG3835@2 NA|NA|NA KT Regulator of polyketide synthase expression OLIIENHM_00148 1440774.Y900_022900 0.0 1684.1 Mycobacteriaceae aceE GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0004739,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016624,GO:0016903,GO:0030312,GO:0032991,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0046872,GO:0055114,GO:0071944,GO:1902494,GO:1990204 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2353T@1762,2GJRE@201174,COG2609@1,COG2609@2 NA|NA|NA C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) OLIIENHM_00149 931627.MycrhDRAFT_4161 6e-42 177.6 Mycobacteriaceae GO:0005575,GO:0005576 Bacteria 236P0@1762,2AP8W@1,2IBG8@201174,31EAV@2 NA|NA|NA OLIIENHM_00150 931627.MycrhDRAFT_4160 1.1e-63 249.2 Mycobacteriaceae Bacteria 238SN@1762,2B57P@1,2IFRB@201174,31Y1M@2 NA|NA|NA S Protein of unknown function (DUF3052) OLIIENHM_00151 164757.Mjls_3370 7.7e-74 283.1 Mycobacteriaceae ahpE GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0020012,GO:0030682,GO:0042221,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0051920,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0070887,GO:0075136,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 ko:K03386 ko04214,map04214 ko00000,ko00001,ko01000,ko04147 Bacteria 238SJ@1762,2GKME@201174,COG1225@1,COG1225@2 NA|NA|NA O Peroxiredoxin OLIIENHM_00155 710696.Intca_0674 1.1e-16 93.6 Intrasporangiaceae ko:K03088 ko00000,ko03021 Bacteria 2IRNG@201174,4FH7C@85021,COG1595@1,COG1595@2 NA|NA|NA K Belongs to the sigma-70 factor family OLIIENHM_00156 367299.JOEE01000004_gene1254 1.1e-20 107.5 Intrasporangiaceae Bacteria 2CD8B@1,2II9F@201174,30VJG@2,4FI3H@85021 NA|NA|NA OLIIENHM_00157 644548.SCNU_00065 2.2e-25 123.2 Gordoniaceae Bacteria 2GMMI@201174,4GD92@85026,COG0582@1,COG0582@2 NA|NA|NA L Belongs to the 'phage' integrase family OLIIENHM_00158 754252.PFREUD_01970 1e-161 576.6 Propionibacteriales Bacteria 2GN3K@201174,4DPZD@85009,COG3177@1,COG3177@2 NA|NA|NA S Fic/DOC family OLIIENHM_00160 931627.MycrhDRAFT_2610 5e-118 430.6 Mycobacteriaceae bioC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0040007,GO:0044424,GO:0044464 2.1.1.197 ko:K02169 ko00780,ko01100,map00780,map01100 M00572 R09543 RC00003,RC00460 ko00000,ko00001,ko00002,ko01000 Bacteria 232I6@1762,2I2MK@201174,COG0500@1,COG0500@2 NA|NA|NA Q Methyltransferase OLIIENHM_00161 1078020.KEK_04937 4.4e-240 837.0 Mycobacteriaceae 1.2.1.3,1.2.1.8 ko:K00128,ko:K00130 ko00010,ko00053,ko00071,ko00260,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00260,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135,M00555 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02565,R02566,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 Bacteria 232IS@1762,2GIWZ@201174,COG1012@1,COG1012@2 NA|NA|NA C Belongs to the aldehyde dehydrogenase family OLIIENHM_00162 1440774.Y900_014770 4e-59 234.2 Mycobacteriaceae 4.2.1.55 ko:K17865 ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200 M00373 R03027 RC00831 ko00000,ko00001,ko00002,ko01000 Bacteria 238N5@1762,2IHRG@201174,COG2030@1,COG2030@2 NA|NA|NA I dehydratase OLIIENHM_00164 931627.MycrhDRAFT_2605 4e-72 277.7 Mycobacteriaceae yxaF ko:K16137,ko:K18939 M00715 ko00000,ko00002,ko03000 Bacteria 2350Q@1762,2GKIE@201174,COG1309@1,COG1309@2 NA|NA|NA K tetR family OLIIENHM_00165 931627.MycrhDRAFT_2603 1.8e-100 372.5 Mycobacteriaceae Bacteria 235S0@1762,28XSP@1,2I9U9@201174,2ZJP4@2 NA|NA|NA S PFAM thioesterase superfamily OLIIENHM_00166 931627.MycrhDRAFT_2602 1.1e-177 629.4 Mycobacteriaceae MA20_40060 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 Bacteria 232U4@1762,2GJ7S@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_00167 931627.MycrhDRAFT_2601 9.1e-118 430.3 Mycobacteriaceae MA20_40065 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 Bacteria 23451@1762,2GUCE@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_00168 931627.MycrhDRAFT_2600 4.3e-117 427.6 Mycobacteriaceae echA1 4.2.1.149,4.2.1.17 ko:K01692,ko:K08299 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093,R10675 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 Bacteria 232DF@1762,2GKJ6@201174,COG1024@1,COG1024@2 NA|NA|NA I Belongs to the enoyl-CoA hydratase isomerase family OLIIENHM_00169 47839.CCAU010000002_gene2414 0.0 2068.1 Mycobacteriaceae eccCa ko:K03466 ko00000,ko03036 3.A.12 Bacteria 233Y8@1762,2GJBR@201174,COG1674@1,COG1674@2 NA|NA|NA D FtsK/SpoIIIE family OLIIENHM_00170 47839.CCAU010000002_gene2413 5.7e-187 660.6 Mycobacteriaceae eccB GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 Bacteria 23351@1762,2GP1Z@201174,COG3266@1,COG3266@2 NA|NA|NA S secretion protein EccB OLIIENHM_00171 931627.MycrhDRAFT_2125 2.2e-32 144.8 Mycobacteriaceae Bacteria 23AA4@1762,2AVE0@1,2IMQH@201174,31M5V@2 NA|NA|NA S Protein of unknown function (DUF2710) OLIIENHM_00172 1370120.AUWR01000076_gene2674 7.2e-142 510.0 Mycobacteriaceae Bacteria 234RA@1762,2GJ6T@201174,COG2141@1,COG2141@2 NA|NA|NA C F420-dependent oxidoreductase, Rv1855c family OLIIENHM_00173 1078020.KEK_21884 5.9e-10 69.3 Mycobacteriaceae Bacteria 23BAX@1762,2B1DU@1,2GT0Y@201174,31TUF@2 NA|NA|NA OLIIENHM_00174 1440774.Y900_012440 1.7e-146 525.4 Mycobacteriaceae gltD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 iJN678.gltD,iNJ661.Rv3858c,iSB619.SA_RS02450 Bacteria 232J4@1762,2GJ0A@201174,COG0493@1,COG0493@2 NA|NA|NA C glutamate synthase OLIIENHM_00176 1172186.KB911466_gene1453 1.1e-133 483.0 Mycobacteriaceae Bacteria 234DT@1762,2GJD2@201174,COG3662@1,COG3662@2 NA|NA|NA S protein conserved in bacteria OLIIENHM_00177 1440774.Y900_018590 2.4e-54 219.5 Mycobacteriaceae Bacteria 2332R@1762,2HH8B@201174,COG3391@1,COG3391@2 NA|NA|NA S amine dehydrogenase activity OLIIENHM_00178 1440774.Y900_018600 1.1e-28 132.5 Mycobacteriaceae Bacteria 23BBR@1762,2B2EH@1,2GUPY@201174,31UZ5@2 NA|NA|NA OLIIENHM_00179 1440774.Y900_018605 6.3e-16 89.7 Mycobacteriaceae Bacteria 23B67@1762,293KS@1,2GRFJ@201174,2ZR2R@2 NA|NA|NA S Belongs to the UPF0337 (CsbD) family OLIIENHM_00180 931627.MycrhDRAFT_3636 4.8e-280 969.9 Mycobacteriaceae fadD14 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0051087 ko:K00666 ko00000,ko01000,ko01004 Bacteria 2338P@1762,2GIUC@201174,COG0318@1,COG0318@2 NA|NA|NA IQ PFAM AMP-dependent synthetase and ligase OLIIENHM_00181 710685.MycrhN_3492 2.3e-207 728.0 Mycobacteriaceae ltp1 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0003988,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005777,GO:0005782,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0031907,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0032787,GO:0034440,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0055114,GO:0070013,GO:0071704,GO:0072329,GO:0097159,GO:1901363,GO:1901575 2.3.1.16 ko:K00632 ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212 M00087,M00113 R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000 Bacteria 232JR@1762,2GIY0@201174,COG0183@1,COG0183@2 NA|NA|NA I Belongs to the thiolase family OLIIENHM_00182 931627.MycrhDRAFT_3638 5.4e-179 633.6 Mycobacteriaceae 1.4.1.12,1.4.1.26 ko:K21672 ko00310,ko00330,ko00472,map00310,map00330,map00472 R02825,R04200,R04201,R04687,R04688 RC00249,RC00790 ko00000,ko00001,ko01000 Bacteria 2341J@1762,2GMU5@201174,COG3804@1,COG3804@2 NA|NA|NA S dihydrodipicolinate reductase OLIIENHM_00183 1440774.Y900_018635 1.3e-60 239.2 Mycobacteriaceae Bacteria 23981@1762,2FAVW@1,2II2J@201174,34330@2 NA|NA|NA S Polyketide cyclase / dehydrase and lipid transport OLIIENHM_00184 1299327.I546_2962 7.5e-58 229.9 Mycobacteriaceae 3.5.1.118 ko:K07008 ko00340,map00340 R11021 RC00064,RC00090 ko00000,ko00001,ko01000 Bacteria 234VY@1762,2GJSY@201174,COG0121@1,COG0121@2 NA|NA|NA S glutamine amidotransferase OLIIENHM_00185 216594.MMAR_4405 2.1e-44 185.3 Mycobacteriaceae 3.5.1.118 ko:K07008 ko00340,map00340 R11021 RC00064,RC00090 ko00000,ko00001,ko01000 Bacteria 234VY@1762,2GJSY@201174,COG0121@1,COG0121@2 NA|NA|NA S glutamine amidotransferase OLIIENHM_00186 36809.MAB_0825 1.6e-128 466.5 Mycobacteriaceae ko:K09684 ko00000,ko03000 Bacteria 235YR@1762,2GNDH@201174,COG2508@1,COG2508@2 NA|NA|NA QT Purine catabolism regulatory protein-like family OLIIENHM_00188 318424.EU78_08475 8.3e-207 726.5 Mycobacteriaceae ko:K22187 ko00040,map00040 R11768 RC00080 ko00000,ko00001,ko01000 Bacteria 236DA@1762,2GMNB@201174,COG1012@1,COG1012@2 NA|NA|NA C Belongs to the aldehyde dehydrogenase family OLIIENHM_00189 1440774.Y900_015085 1.2e-203 715.7 Mycobacteriaceae gcdH GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 1.3.8.6 ko:K00252 ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130 M00032 R02487,R02488,R10074 RC00052,RC00156 ko00000,ko00001,ko00002,ko01000 Bacteria 2336I@1762,2GIX8@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_00190 931627.MycrhDRAFT_2821 2.8e-201 708.0 Mycobacteriaceae gabD 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 Bacteria 235T4@1762,2GIWZ@201174,COG1012@1,COG1012@2 NA|NA|NA C Catalyzes the NADP( )-dependent oxidation of succinate semialdehyde to succinate. It is believed to be the main source of succinate semialdehyde dehydrogenase activity in Mycobacterium OLIIENHM_00191 1341646.CBMO010000115_gene2201 3.7e-115 421.4 Mycobacteriaceae rssA GO:0003674,GO:0003824,GO:0016787 ko:K07001 ko00000 Bacteria 2337P@1762,2GNBM@201174,COG1752@1,COG1752@2 NA|NA|NA S Esterase of the alpha-beta hydrolase superfamily OLIIENHM_00192 1440774.Y900_018660 1.4e-32 146.0 Mycobacteriaceae lpqV Bacteria 23AY6@1762,2AWM4@1,2IPKZ@201174,31NHV@2 NA|NA|NA S Putative lipoprotein LpqV OLIIENHM_00193 1440774.Y900_018675 1.4e-258 898.7 Mycobacteriaceae Bacteria 233TZ@1762,2GKB5@201174,COG4425@1,COG4425@2 NA|NA|NA S membrane OLIIENHM_00194 931627.MycrhDRAFT_3714 5.2e-123 447.2 Mycobacteriaceae echA8 GO:0003674,GO:0003824,GO:0004300,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0030312,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 Bacteria 23616@1762,2GJW5@201174,COG1024@1,COG1024@2 NA|NA|NA I Belongs to the enoyl-CoA hydratase isomerase family OLIIENHM_00195 1078020.KEK_02971 1.8e-139 502.3 Mycobacteriaceae echA9 3.1.2.4,4.2.1.17 ko:K01692,ko:K05605 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01200,map01212 M00013,M00032,M00087 R03026,R03045,R03158,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05064,R05595,R06411,R06412,R06942,R08093 RC00004,RC00014,RC00137,RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 Bacteria 23602@1762,2GMET@201174,COG1024@1,COG1024@2 NA|NA|NA I Enoyl-CoA hydratase OLIIENHM_00196 931627.MycrhDRAFT_3716 1.6e-117 429.1 Mycobacteriaceae Bacteria 235D1@1762,2GNCK@201174,COG4760@1,COG4760@2 NA|NA|NA S membrane OLIIENHM_00197 557599.MKAN_07420 8.1e-93 347.1 Mycobacteriaceae Bacteria 233BV@1762,2GN40@201174,COG2852@1,COG2852@2 NA|NA|NA S Protein conserved in bacteria OLIIENHM_00198 1370120.AUWR01000012_gene1152 4.6e-118 430.6 Mycobacteriaceae fadA3 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0003988,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005777,GO:0005782,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0031907,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0032787,GO:0034440,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0055114,GO:0070013,GO:0071704,GO:0072329,GO:0097159,GO:1901363,GO:1901575 2.3.1.16,2.3.1.9 ko:K00626,ko:K00632 ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00087,M00088,M00095,M00113,M00373,M00374,M00375 R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 23617@1762,2GJAC@201174,COG0183@1,COG0183@2 NA|NA|NA I Belongs to the thiolase family OLIIENHM_00199 1440774.Y900_006520 6e-90 337.4 Mycobacteriaceae birA GO:0000166,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004077,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009305,GO:0009374,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0017053,GO:0017076,GO:0017144,GO:0018130,GO:0018271,GO:0019538,GO:0019752,GO:0019842,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032991,GO:0033218,GO:0033293,GO:0034641,GO:0035639,GO:0036094,GO:0036211,GO:0042364,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043565,GO:0043603,GO:0043604,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1990837 2.7.1.33,6.3.4.15 ko:K01947,ko:K03524 ko00770,ko00780,ko01100,map00770,map00780,map01100 M00120 R01074,R02971,R03018,R04391,R05145 RC00002,RC00017,RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko00002,ko01000,ko03000 Bacteria 232YE@1762,2GN8Q@201174,COG0340@1,COG0340@2 NA|NA|NA H biotin lipoate A B protein ligase OLIIENHM_00201 1150599.MPHLEI_02373 2.9e-96 358.2 Mycobacteriaceae Bacteria 232PR@1762,2GIX4@201174,COG0318@1,COG0318@2 NA|NA|NA IQ COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases OLIIENHM_00202 931627.MycrhDRAFT_1009 1.1e-219 769.2 Mycobacteriaceae lytR2 Bacteria 233RI@1762,2GJM3@201174,COG1316@1,COG1316@2 NA|NA|NA K cell envelope-related transcriptional attenuator OLIIENHM_00203 350058.Mvan_1727 7.1e-97 360.5 Mycobacteriaceae rmlD GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008831,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019305,GO:0019438,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 Bacteria 2364N@1762,2GNY8@201174,COG1091@1,COG1091@2 NA|NA|NA M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose OLIIENHM_00204 1440774.Y900_006500 1.2e-139 502.7 Mycobacteriaceae wbbL GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0045226,GO:0046379,GO:0071704,GO:0071944,GO:1901576 2.4.1.289 ko:K07011,ko:K16870 ko00000,ko01000,ko01003 iNJ661.Rv3265c Bacteria 232RP@1762,2GIUN@201174,COG1216@1,COG1216@2 NA|NA|NA S PFAM Glycosyl transferase family 2 OLIIENHM_00205 931627.MycrhDRAFT_1012 2.3e-153 548.5 Mycobacteriaceae manC 2.7.7.13,5.4.2.8 ko:K00966,ko:K16881 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114,M00361,M00362 R00885,R01818 RC00002,RC00408 ko00000,ko00001,ko00002,ko01000 Bacteria 235M9@1762,2GKTE@201174,COG1208@1,COG1208@2 NA|NA|NA JM Nucleotidyl transferase OLIIENHM_00206 525368.HMPREF0591_4051 2.1e-65 255.4 Mycobacteriaceae nudJ ko:K12152 ko00000,ko01000 Bacteria 2380C@1762,2GU6D@201174,COG0494@1,COG0494@2 NA|NA|NA L Nudix hydrolase OLIIENHM_00207 1440774.Y900_006485 8.5e-198 696.4 Mycobacteriaceae fbiB GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0044237,GO:0044249,GO:0044464,GO:0051186,GO:0051188,GO:0071944 6.3.2.31,6.3.2.34 ko:K12234 ko00680,ko01120,map00680,map01120 M00378 R09399,R09400 RC00064,RC00090,RC00141 ko00000,ko00001,ko00002,ko01000 Bacteria 23441@1762,2GMJ8@201174,COG0778@1,COG0778@2,COG1478@1,COG1478@2 NA|NA|NA H Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives OLIIENHM_00208 1440774.Y900_006480 2.7e-159 568.2 Mycobacteriaceae cofD GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016773,GO:0043743,GO:0044237,GO:0044249,GO:0051186,GO:0051188 2.7.8.28 ko:K11212 ko00680,ko01120,map00680,map01120 M00378 R09398 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 232HR@1762,2GJZ2@201174,COG0391@1,COG0391@2 NA|NA|NA H Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP OLIIENHM_00209 931627.MycrhDRAFT_1016 4.2e-40 170.6 Mycobacteriaceae whiB2 ko:K18955 ko00000,ko03000 Bacteria 239E8@1762,2CC1Y@1,2IQ4Q@201174,32RUK@2 NA|NA|NA K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA OLIIENHM_00210 710421.Mycch_1344 3.2e-68 264.6 Mycobacteriaceae MA20_43655 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 Bacteria 238JQ@1762,2IS6W@201174,COG3824@1,COG3824@2 NA|NA|NA S Zincin-like metallopeptidase OLIIENHM_00211 1440774.Y900_006465 9.6e-43 179.5 Mycobacteriaceae Bacteria 238WZ@1762,2C7XW@1,2IQ5R@201174,32RR4@2 NA|NA|NA S Protein of unknown function (DUF3499) OLIIENHM_00212 1341646.CBMO010000054_gene3647 1.6e-207 728.8 Mycobacteriaceae manB GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 5.4.2.2,5.4.2.8 ko:K01840,ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 iECS88_1305.ECS88_2145,iECUMN_1333.ECUMN_2384,iUTI89_1310.UTI89_C2321 Bacteria 234C9@1762,2GJQA@201174,COG1109@1,COG1109@2 NA|NA|NA G the resulting product is then converted to GDP-mannose by ManC which is then used in the synthesis of mannose-containing glycoconjugates that are important for mediating entry into host cells OLIIENHM_00213 931627.MycrhDRAFT_1020 1.2e-130 473.0 Mycobacteriaceae 5.3.1.8,5.3.1.9 ko:K15916 ko00010,ko00030,ko00051,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R01819,R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000 Bacteria 235Q0@1762,2GMG0@201174,COG1737@1,COG1737@2 NA|NA|NA K Transcriptional regulator OLIIENHM_00214 1440774.Y900_006450 3.4e-185 654.4 Mycobacteriaceae manA GO:0000032,GO:0000271,GO:0003674,GO:0003824,GO:0004476,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005996,GO:0006013,GO:0006056,GO:0006057,GO:0006139,GO:0006464,GO:0006486,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009226,GO:0009242,GO:0009298,GO:0009987,GO:0016051,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019309,GO:0019318,GO:0019320,GO:0019438,GO:0019538,GO:0019673,GO:0031506,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0036211,GO:0042546,GO:0043170,GO:0043412,GO:0043413,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046377,GO:0046483,GO:0055086,GO:0070085,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 1.14.13.81,5.3.1.8,5.4.2.8 ko:K01809,ko:K01840,ko:K04035 ko00051,ko00520,ko00860,ko01100,ko01110,ko01130,map00051,map00520,map00860,map01100,map01110,map01130 M00114 R01818,R01819,R06265,R06266,R06267,R10068 RC00376,RC00408,RC00741,RC01491,RC01492,RC03042 ko00000,ko00001,ko00002,ko01000 iAPECO1_1312.APECO1_696,iECOK1_1307.ECOK1_1731,iECS88_1305.ECS88_1659,iSFV_1184.SFV_1629,iSF_1195.SF1636,iSFxv_1172.SFxv_1833,iS_1188.S1767,iUMN146_1321.UM146_09090,iUTI89_1310.UTI89_C1801 Bacteria 233WK@1762,2GJXC@201174,COG1482@1,COG1482@2 NA|NA|NA G mannose-6-phosphate isomerase OLIIENHM_00215 931627.MycrhDRAFT_1024 6e-216 756.9 Mycobacteriaceae ko:K03294 ko00000 2.A.3.2 Bacteria 23292@1762,2GJ75@201174,COG0531@1,COG0531@2 NA|NA|NA E amino acid OLIIENHM_00216 164757.Mjls_1371 3.5e-76 291.2 Mycobacteriaceae Bacteria 234N0@1762,2GMDA@201174,COG1309@1,COG1309@2 NA|NA|NA K Transcriptional regulator OLIIENHM_00217 931627.MycrhDRAFT_3887 2.8e-32 144.4 Mycobacteriaceae Bacteria 234E2@1762,2GMZQ@201174,COG3173@1,COG3173@2 NA|NA|NA S Phosphotransferase OLIIENHM_00218 1440774.Y900_026880 2.1e-48 199.1 Mycobacteriaceae Bacteria 239D8@1762,2I15N@201174,COG1714@1,COG1714@2 NA|NA|NA S Pfam RDD OLIIENHM_00219 1265310.CCBD010000055_gene1404 2.3e-28 132.1 Mycobacteriaceae doxX ko:K15977 ko00000 Bacteria 236BH@1762,2HD6Y@201174,COG2259@1,COG2259@2 NA|NA|NA S DoxX OLIIENHM_00220 1440774.Y900_026865 2.2e-101 375.2 Mycobacteriaceae Bacteria 2342J@1762,2GQ0Z@201174,COG4122@1,COG4122@2 NA|NA|NA S Methyltransferase domain OLIIENHM_00221 931627.MycrhDRAFT_3876 4.3e-165 587.4 Mycobacteriaceae Bacteria 234R4@1762,2GKU7@201174,COG3387@1,COG3387@2 NA|NA|NA G PFAM Glycoside hydrolase 15-related OLIIENHM_00222 931627.MycrhDRAFT_3875 1.5e-111 409.1 Mycobacteriaceae Bacteria 232FS@1762,2H38T@201174,COG0500@1,COG2226@2 NA|NA|NA Q Methyltransferase OLIIENHM_00223 931627.MycrhDRAFT_3874 1.6e-190 672.2 Mycobacteriaceae gt4G Bacteria 2329J@1762,2GMXE@201174,COG0438@1,COG0438@2 NA|NA|NA M PFAM Glycosyl transferase, group 1 OLIIENHM_00224 931627.MycrhDRAFT_3873 1.6e-76 292.7 Mycobacteriaceae blaB3 Bacteria 232Z3@1762,2GMHY@201174,COG0491@1,COG0491@2 NA|NA|NA S Metallo-beta-lactamase superfamily OLIIENHM_00225 931627.MycrhDRAFT_3872 0.0 1355.5 Mycobacteriaceae gabT 2.6.1.19,2.6.1.22 ko:K00823,ko:K07250 ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648,R04188 RC00006,RC00062,RC00160 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 234TQ@1762,2GKVH@201174,COG0160@1,COG0160@2,COG2334@1,COG2334@2 NA|NA|NA E Aminotransferase OLIIENHM_00226 1440774.Y900_026835 1.8e-77 295.4 Mycobacteriaceae pncA GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008936,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0018130,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0030145,GO:0034641,GO:0034654,GO:0043094,GO:0043167,GO:0043169,GO:0043173,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.11.1,3.5.1.19 ko:K08281,ko:K12132 ko00760,ko01100,map00760,map01100 R01268 RC00100 ko00000,ko00001,ko01000,ko01001 iE2348C_1286.E2348C_1895,iECs_1301.ECs2475,iZ_1308.Z2802 Bacteria 238SY@1762,2IFQW@201174,COG1335@1,COG1335@2 NA|NA|NA Q Isochorismatase family OLIIENHM_00227 1440774.Y900_026815 1.3e-119 436.0 Mycobacteriaceae potC ko:K11070 ko02010,map02010 M00299 ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 Bacteria 232G4@1762,2GJ6Q@201174,COG1177@1,COG1177@2 NA|NA|NA E inner membrane component OLIIENHM_00228 1440774.Y900_026810 7.6e-139 500.0 Mycobacteriaceae potH ko:K11071 ko02010,map02010 M00299 ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 Bacteria 233PW@1762,2GJ5G@201174,COG1176@1,COG1176@2 NA|NA|NA P ABC-type spermidine putrescine transport system, permease component I OLIIENHM_00229 931627.MycrhDRAFT_3860 1.2e-171 609.4 Mycobacteriaceae ko:K11069 ko02010,map02010 M00299 ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 Bacteria 232YQ@1762,2GKVG@201174,COG0687@1,COG0687@2 NA|NA|NA E Extracellular solute-binding protein OLIIENHM_00230 931627.MycrhDRAFT_3859 1.1e-187 662.5 Mycobacteriaceae potA 3.6.3.31 ko:K11072 ko02010,map02010 M00299 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.11.1 Bacteria 2329P@1762,2GJCM@201174,COG3842@1,COG3842@2 NA|NA|NA E Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system OLIIENHM_00231 1440774.Y900_026785 1.6e-111 409.1 Mycobacteriaceae Bacteria 232U5@1762,2GNVA@201174,COG1028@1,COG1028@2 NA|NA|NA IQ Belongs to the short-chain dehydrogenases reductases (SDR) family OLIIENHM_00232 931627.MycrhDRAFT_3855 4e-129 467.6 Mycobacteriaceae ko:K02066 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 2329K@1762,2GXR8@201174,COG0767@1,COG0767@2 NA|NA|NA Q ABC-type transport system involved in resistance to organic solvents, permease component OLIIENHM_00233 710685.MycrhN_4033 9.2e-121 439.9 Mycobacteriaceae ko:K02066 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 233I4@1762,2GJ27@201174,COG0767@1,COG0767@2 NA|NA|NA Q ABC-type transport system involved in resistance to organic solvents, permease component OLIIENHM_00234 1440774.Y900_026770 3.1e-159 568.2 Mycobacteriaceae ko:K02067 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 235TJ@1762,2GNXB@201174,COG1463@1,COG1463@2 NA|NA|NA Q Virulence factor Mce family protein OLIIENHM_00235 1041522.MCOL_V210210 2.9e-129 468.4 Mycobacteriaceae ko:K02067 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 233RH@1762,2GKHV@201174,COG1463@1,COG1463@2 NA|NA|NA Q Virulence factor Mce family protein OLIIENHM_00236 931627.MycrhDRAFT_3851 1.1e-139 503.1 Mycobacteriaceae ko:K02067 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 232P6@1762,2GMU6@201174,COG1463@1,COG1463@2 NA|NA|NA Q Virulence factor Mce family protein OLIIENHM_00237 1440774.Y900_026755 8.7e-191 673.3 Mycobacteriaceae Bacteria 233HQ@1762,2GNXN@201174,COG1463@1,COG1463@2 NA|NA|NA Q Virulence factor Mce family protein OLIIENHM_00238 931627.MycrhDRAFT_3849 1.1e-130 473.4 Mycobacteriaceae ko:K02067 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 234N1@1762,2GJVB@201174,COG1463@1,COG1463@2 NA|NA|NA Q Virulence factor Mce family protein OLIIENHM_00239 931627.MycrhDRAFT_3848 2.2e-200 705.3 Mycobacteriaceae ko:K02067 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 232GJ@1762,2GNEP@201174,COG1463@1,COG1463@2 NA|NA|NA Q Virulence factor Mce family protein OLIIENHM_00240 931627.MycrhDRAFT_3847 1.9e-62 245.4 Mycobacteriaceae Bacteria 238T4@1762,2AU6A@1,2IJTM@201174,31JT8@2 NA|NA|NA OLIIENHM_00241 1440774.Y900_026735 3e-218 764.6 Mycobacteriaceae ksdD 1.3.99.4 ko:K05898 ko00984,ko01100,ko01120,map00984,map01100,map01120 R09884 RC00991 ko00000,ko00001,ko01000 Bacteria 234AA@1762,2GM5I@201174,COG1053@1,COG1053@2 NA|NA|NA C Succinate dehydrogenase fumarate reductase flavoprotein subunit OLIIENHM_00242 1440774.Y900_026530 1.5e-255 889.0 Mycobacteriaceae GO:0000287,GO:0003674,GO:0003824,GO:0004016,GO:0004383,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006171,GO:0006182,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0007186,GO:0007187,GO:0007188,GO:0007189,GO:0008074,GO:0008150,GO:0008152,GO:0008179,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009975,GO:0009987,GO:0010033,GO:0014070,GO:0016020,GO:0016021,GO:0016829,GO:0016849,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019899,GO:0019932,GO:0019933,GO:0019935,GO:0023052,GO:0030145,GO:0030425,GO:0031224,GO:0031226,GO:0031683,GO:0032991,GO:0033993,GO:0034641,GO:0034654,GO:0035556,GO:0035690,GO:0036477,GO:0042221,GO:0042493,GO:0042995,GO:0043005,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044444,GO:0044445,GO:0044459,GO:0044463,GO:0044464,GO:0044877,GO:0045121,GO:0046058,GO:0046068,GO:0046390,GO:0046483,GO:0046677,GO:0046872,GO:0046914,GO:0046982,GO:0046983,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052652,GO:0055086,GO:0061478,GO:0065007,GO:0070887,GO:0071236,GO:0071310,GO:0071396,GO:0071407,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097305,GO:0097306,GO:0097447,GO:0097458,GO:0098589,GO:0098805,GO:0098857,GO:0120025,GO:0120038,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901654,GO:1901655,GO:1901700,GO:1901701,GO:1904321,GO:1904322 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 Bacteria 232IH@1762,2GIVE@201174,COG2114@1,COG2114@2,COG5000@1,COG5000@2 NA|NA|NA T Guanylate cyclase OLIIENHM_00243 931627.MycrhDRAFT_3811 4.3e-160 571.2 Mycobacteriaceae Bacteria 2346J@1762,2GZI1@201174,COG0664@1,COG0664@2,COG0668@1,COG0668@2 NA|NA|NA MT mechanosensitive OLIIENHM_00244 1440774.Y900_026505 1.8e-177 629.0 Mycobacteriaceae Bacteria 232MW@1762,2H8UD@201174,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily OLIIENHM_00245 1440774.Y900_026500 1.8e-89 335.9 Mycobacteriaceae Bacteria 232AJ@1762,2I158@201174,COG2050@1,COG2050@2 NA|NA|NA Q Thioesterase-like superfamily OLIIENHM_00246 525368.HMPREF0591_4739 8e-80 303.5 Mycobacteriaceae GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 ko:K07100 ko00000 Bacteria 236TQ@1762,2GJUU@201174,COG1073@1,COG1073@2,COG1926@1,COG1926@2 NA|NA|NA S phosphoribosyl transferase OLIIENHM_00247 1370121.AUWS01000008_gene5645 1.9e-97 362.5 Mycobacteriaceae sseB 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 Bacteria 232MU@1762,2GMDR@201174,COG2897@1,COG2897@2 NA|NA|NA P sulfurtransferase OLIIENHM_00248 931627.MycrhDRAFT_3797 4.2e-16 90.5 Mycobacteriaceae Bacteria 23BJW@1762,29GPM@1,2GRKU@201174,303MC@2 NA|NA|NA OLIIENHM_00251 350058.Mvan_5243 6.7e-108 397.9 Mycobacteriaceae Bacteria 2378H@1762,2DC1N@1,2I9JK@201174,2ZCGR@2 NA|NA|NA OLIIENHM_00252 710421.Mycch_4351 3.5e-99 368.2 Mycobacteriaceae lpqC ko:K03932 ko00000 CE1 Bacteria 235MS@1762,2GNV6@201174,COG3509@1,COG3509@2 NA|NA|NA Q esterase OLIIENHM_00253 1370120.AUWR01000012_gene1219 1.1e-66 260.0 Mycobacteriaceae ko:K03603,ko:K05799 ko00000,ko03000 Bacteria 238VK@1762,2I90D@201174,COG2186@1,COG2186@2 NA|NA|NA K FCD OLIIENHM_00254 522306.CAP2UW1_2237 1.5e-24 120.2 Betaproteobacteria Bacteria 1R75P@1224,2VU4P@28216,COG1075@1,COG1075@2 NA|NA|NA S PGAP1-like protein OLIIENHM_00256 710685.MycrhN_4073 6.4e-68 265.8 Mycobacteriaceae 3.1.3.3 ko:K07315,ko:K20971 ko02025,map02025 ko00000,ko00001,ko01000,ko01001,ko02022,ko03021 Bacteria 23FCK@1762,2I43Y@201174,COG2208@1,COG2208@2,COG4251@1,COG4251@2 NA|NA|NA T GAF domain OLIIENHM_00257 1440774.Y900_017255 2e-240 839.3 Bacteria ko:K15125 ko05133,map05133 ko00000,ko00001,ko00536 Bacteria COG3210@1,COG3210@2,COG3420@1,COG3420@2 NA|NA|NA P alginic acid biosynthetic process OLIIENHM_00258 258533.BN977_03814 4.9e-68 264.2 Mycobacteriaceae fkbB 5.2.1.8 ko:K01802 ko00000,ko01000 Bacteria 238U7@1762,2GJK2@201174,COG0545@1,COG0545@2 NA|NA|NA O Peptidyl-prolyl cis-trans OLIIENHM_00259 1157943.KB892705_gene3263 2.9e-116 425.2 Mycobacteriaceae phnS ko:K11081,ko:K11083 ko02010,map02010 M00302 ko00000,ko00001,ko00002,ko02000 3.A.1.11.5 Bacteria 235W4@1762,2I33Y@201174,COG1840@1,COG1840@2 NA|NA|NA P Bacterial extracellular solute-binding protein OLIIENHM_00260 931627.MycrhDRAFT_3949 8.2e-86 323.6 Mycobacteriaceae Bacteria 234HJ@1762,2HMKZ@201174,COG2050@1,COG2050@2 NA|NA|NA Q Thioesterase-like superfamily OLIIENHM_00261 1194972.MVAC_24061 1.1e-209 736.1 Mycobacteriaceae 1.13.11.75 ko:K00464,ko:K11159 R09601 RC00912 ko00000,ko01000 Bacteria 234VQ@1762,2GK7D@201174,COG3670@1,COG3670@2 NA|NA|NA Q Retinal pigment epithelial membrane protein OLIIENHM_00262 1209984.BN978_02715 8.7e-108 396.7 Mycobacteriaceae scnB 3.5.5.8 ko:K20760,ko:K20761 ko00000,ko01000 Bacteria 234TE@1762,2DYBW@1,2H72K@201174,32V56@2 NA|NA|NA S Nitrile hydratase beta subunit OLIIENHM_00263 337191.KTR9_4745 3.4e-116 424.5 Gordoniaceae scnC 3.5.5.8,4.2.1.84 ko:K01721,ko:K20762 ko00364,ko00380,ko00627,ko00643,ko01120,map00364,map00380,map00627,map00643,map01120 R02828,R04020,R05379,R05596,R07780,R07854 RC00483,RC00792,RC01345,RC01432 ko00000,ko00001,ko01000 Bacteria 2BZ0R@1,2GU1J@201174,2Z7U0@2,4GDIK@85026 NA|NA|NA S Nitrile hydratase, alpha chain OLIIENHM_00264 1123258.AQXZ01000019_gene2954 2.5e-38 164.9 Nocardiaceae Bacteria 2EEJS@1,2IM2I@201174,338DQ@2,4G1XY@85025 NA|NA|NA OLIIENHM_00265 1440774.Y900_021440 3.7e-141 508.1 Mycobacteriaceae ko:K07241 ko00000,ko02000 2.A.52.1 Bacteria 23576@1762,2GJZB@201174,COG2042@1,COG3376@2 NA|NA|NA S rRNA processing OLIIENHM_00266 350058.Mvan_5243 4.5e-112 411.4 Mycobacteriaceae Bacteria 2378H@1762,2DC1N@1,2I9JK@201174,2ZCGR@2 NA|NA|NA OLIIENHM_00267 1299327.I546_3457 1.6e-129 469.2 Mycobacteriaceae Bacteria 23835@1762,28MHV@1,2IA17@201174,2ZAUP@2 NA|NA|NA S Tocopherol cyclase OLIIENHM_00268 164757.Mjls_3855 8.5e-241 839.7 Mycobacteriaceae fadD31 ko:K00666,ko:K12423,ko:K12426,ko:K12428 ko00000,ko01000,ko01004 Bacteria 233BE@1762,2I2RH@201174,COG0318@1,COG0318@2 NA|NA|NA IQ Fatty-acid--CoA ligase OLIIENHM_00269 1440774.Y900_026110 1.9e-104 385.6 Mycobacteriaceae ko:K10805 ko01040,map01040 ko00000,ko00001,ko01000,ko01004 Bacteria 234XS@1762,2HJWS@201174,COG1946@1,COG1946@2 NA|NA|NA I Acyl-CoA thioesterase OLIIENHM_00270 1440774.Y900_026105 9.7e-30 136.0 Mycobacteriaceae Bacteria 23DPJ@1762,2ATJW@1,2H5EG@201174,321E7@2 NA|NA|NA S Domain of unknown function (DUF4193) OLIIENHM_00271 931627.MycrhDRAFT_5937 7.2e-54 216.9 Mycobacteriaceae rpfI ko:K21471,ko:K21473 ko00000,ko01000,ko01002,ko01011 Bacteria 236IG@1762,2I068@201174,COG0791@1,COG0791@2 NA|NA|NA M COG0791 Cell wall-associated hydrolases (invasion-associated proteins) OLIIENHM_00272 1440774.Y900_026075 1.9e-240 838.2 Mycobacteriaceae 2.6.1.55 ko:K15372 ko00410,ko00430,ko01100,map00410,map00430,map01100 R00908,R01684 RC00006,RC00062 ko00000,ko00001,ko01000 Bacteria 2356J@1762,2I2F3@201174,COG0160@1,COG0160@2 NA|NA|NA E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family OLIIENHM_00273 1440774.Y900_026070 2.1e-14 85.1 Mycobacteriaceae Bacteria 23B0T@1762,2AXE4@1,2IQR7@201174,31PDG@2 NA|NA|NA OLIIENHM_00274 1440774.Y900_026050 1.8e-114 419.1 Mycobacteriaceae Bacteria 23DCV@1762,2GKC7@201174,COG1063@1,COG1063@2 NA|NA|NA E Alcohol dehydrogenase GroES-like domain OLIIENHM_00275 710685.MycrhN_3760 2.2e-210 738.4 Mycobacteriaceae GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.1.99.1 ko:K00108 ko00260,ko01100,map00260,map01100 M00555 R01025 RC00087 ko00000,ko00001,ko00002,ko01000 Bacteria 233HY@1762,2GJAU@201174,COG2303@1,COG2303@2 NA|NA|NA E Belongs to the GMC oxidoreductase family OLIIENHM_00277 1209984.BN978_04989 2.3e-141 508.4 Mycobacteriaceae citE_2 4.1.3.25,4.1.3.34 ko:K01644,ko:K18292 ko00660,ko01100,ko02020,map00660,map01100,map02020 R00237,R00362 RC00067,RC00502,RC01118,RC01205 ko00000,ko00001,ko01000 Bacteria 23556@1762,2GK5J@201174,COG2301@1,COG2301@2 NA|NA|NA G Belongs to the HpcH HpaI aldolase family OLIIENHM_00278 1440774.Y900_026040 3.2e-109 401.7 Mycobacteriaceae Bacteria 23FCY@1762,2HEUW@201174,COG1511@1,COG1511@2 NA|NA|NA S domain protein OLIIENHM_00279 931627.MycrhDRAFT_5926 3.9e-136 491.1 Mycobacteriaceae ko:K07140 ko00000 Bacteria 2367T@1762,2GND9@201174,COG3217@1,COG3217@2 NA|NA|NA S MOSC domain OLIIENHM_00280 1380386.JIAW01000005_gene1501 7e-101 374.0 Mycobacteriaceae menC 4.2.1.113,5.1.1.20,5.1.1.3 ko:K01776,ko:K02549,ko:K19802 ko00130,ko00471,ko01100,ko01110,map00130,map00471,map01100,map01110 M00116 R00260,R04031,R10938 RC00302,RC01053,RC03309 ko00000,ko00001,ko00002,ko01000,ko01011 iSB619.SA_RS09080 Bacteria 235ZT@1762,2GJJR@201174,COG4948@1,COG4948@2 NA|NA|NA M Belongs to the mandelate racemase muconate lactonizing enzyme family OLIIENHM_00281 1440774.Y900_026020 4.1e-132 477.6 Mycobacteriaceae 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 Bacteria 235HA@1762,2GM4R@201174,COG0685@1,COG0685@2 NA|NA|NA E methylenetetrahydrofolate reductase (NAD(P)H) activity OLIIENHM_00282 1172186.KB911464_gene4846 7.6e-59 233.4 Mycobacteriaceae furA GO:0003674,GO:0003700,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009889,GO:0010035,GO:0010038,GO:0010039,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042221,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141 ko:K22297 ko00000,ko03000 Bacteria 238ME@1762,2IFBR@201174,COG0735@1,COG0735@2 NA|NA|NA P Belongs to the Fur family OLIIENHM_00283 1380386.JIAW01000001_gene4650 7.6e-65 253.4 Mycobacteriaceae Bacteria 233FP@1762,2I8YR@201174,COG1853@1,COG1853@2 NA|NA|NA S COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family OLIIENHM_00284 1440774.Y900_014925 1.1e-250 872.5 Mycobacteriaceae fadD21 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070566,GO:0071704,GO:0071944,GO:0072330,GO:1901576 ko:K12423,ko:K12428 ko00000,ko01004 Bacteria 2343A@1762,2I2RH@201174,COG0318@1,COG0318@2 NA|NA|NA IQ Activates fatty acids by binding to coenzyme A OLIIENHM_00285 931627.MycrhDRAFT_2629 2.6e-80 305.1 Mycobacteriaceae Bacteria 234FM@1762,2F6DN@1,2GKWZ@201174,33YWV@2 NA|NA|NA S Sap, sulfolipid-1-addressing protein OLIIENHM_00286 1440774.Y900_014915 3.8e-141 508.1 Mycobacteriaceae GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 Bacteria 232NF@1762,2GJ85@201174,COG5651@1,COG5651@2 NA|NA|NA N domain protein OLIIENHM_00287 931627.MycrhDRAFT_2627 0.0 1395.9 Mycobacteriaceae mmpL10 GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 ko:K06994 ko00000 Bacteria 232DR@1762,2GIRQ@201174,COG2409@1,COG2409@2 NA|NA|NA S transport protein OLIIENHM_00288 1440774.Y900_014905 5.2e-238 830.1 Mycobacteriaceae pvdL GO:0003674,GO:0003824,GO:0005975,GO:0005984,GO:0005991,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009311,GO:0009987,GO:0016409,GO:0016740,GO:0016746,GO:0016747,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044262,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 Bacteria 232PE@1762,2GSQU@201174,COG1020@1,COG1020@2 NA|NA|NA Q COG1020 Non-ribosomal peptide synthetase modules and related proteins OLIIENHM_00289 1440774.Y900_014900 0.0 5856.6 Mycobacteriaceae pltC ko:K12436,ko:K16128,ko:K16394,ko:K16397 ko01052,ko01054,map01052,map01054 ko00000,ko00001,ko01004,ko01008 Bacteria 232E7@1762,2H477@201174,COG3321@1,COG3321@2 NA|NA|NA Q polyketide synthase OLIIENHM_00290 262316.MAP_3694c 8.1e-308 1062.4 Mycobacteriaceae acd Bacteria 232B2@1762,2GJIB@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_00291 1449048.JQKU01000005_gene4689 1e-112 412.9 Mycobacteriaceae desA3 1.14.19.3 ko:K00508 ko00591,ko01100,map00591,map01100 R07063 RC00917 ko00000,ko00001,ko01000,ko01004 Bacteria 238AX@1762,2HPN1@201174,COG3239@1,COG3239@2 NA|NA|NA I Fatty acid desaturase OLIIENHM_00292 931627.MycrhDRAFT_3216 4e-116 424.5 Mycobacteriaceae Bacteria 235TR@1762,2GJ78@201174,COG2267@1,COG2267@2 NA|NA|NA I Alpha beta hydrolase OLIIENHM_00293 557599.MKAN_15515 5.8e-180 637.5 Mycobacteriaceae ko:K00666 ko00000,ko01000,ko01004 Bacteria 23D29@1762,2H3KM@201174,COG0318@1,COG0318@2 NA|NA|NA IQ AMP-binding enzyme OLIIENHM_00294 36809.MAB_4670c 4.6e-22 110.5 Mycobacteriaceae ko:K02078 ko00000,ko00001 Bacteria 23EBD@1762,2BA37@1,2H85E@201174,323H0@2 NA|NA|NA Q Phosphopantetheine attachment site OLIIENHM_00295 557599.MKAN_15525 4.9e-143 514.2 Bacteria devC ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria COG0577@1,COG0577@2 NA|NA|NA V efflux transmembrane transporter activity OLIIENHM_00296 1440774.Y900_027490 3.1e-98 364.8 Actinobacteria Bacteria 2IB3E@201174,COG1305@1,COG1305@2 NA|NA|NA E Transglutaminase-like superfamily OLIIENHM_00297 557599.MKAN_15550 8.5e-86 323.6 Mycobacteriaceae hrtA ko:K02003,ko:K09814 ko02010,map02010 M00257,M00258 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1 Bacteria 233TP@1762,2GJN6@201174,COG1136@1,COG1136@2 NA|NA|NA V ABC transporter OLIIENHM_00298 557599.MKAN_15555 2e-144 518.8 Bacteria devC ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria COG0577@1,COG0577@2 NA|NA|NA V efflux transmembrane transporter activity OLIIENHM_00299 557599.MKAN_15530 1.6e-144 519.2 Mycobacteriaceae nifS 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 Bacteria 23D8S@1762,2GKUT@201174,COG1104@1,COG1104@2 NA|NA|NA E Aminotransferase class-V OLIIENHM_00300 36809.MAB_4674c 1.2e-43 182.6 Mycobacteriaceae ko:K04488,ko:K15790 ko00000 Bacteria 23DWQ@1762,2H0PK@201174,COG0822@1,COG0822@2 NA|NA|NA C NifU-like N terminal domain OLIIENHM_00301 36809.MAB_4675c 1.7e-175 622.1 Actinobacteria luxE 6.2.1.19 ko:K06046 ko02020,ko02024,map02020,map02024 ko00000,ko00001,ko01000 Bacteria 2I8ZH@201174,COG1541@1,COG1541@2 NA|NA|NA H Acyl-protein synthetase, LuxE OLIIENHM_00302 1440774.Y900_014750 2.6e-11 77.0 Mycobacteriaceae Bacteria 236FI@1762,2A5HF@1,2I8Z4@201174,30U7N@2 NA|NA|NA OLIIENHM_00303 931627.MycrhDRAFT_0373 8.4e-31 140.2 Mycobacteriaceae Bacteria 239AT@1762,2AN8T@1,2IHRU@201174,31D6V@2 NA|NA|NA S Domain of unknown function (DUF4395) OLIIENHM_00304 931627.MycrhDRAFT_6866 2.5e-71 275.4 Mycobacteriaceae GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 Bacteria 2368R@1762,2IHDZ@201174,COG5660@1,COG5660@2 NA|NA|NA S Putative zinc-finger OLIIENHM_00305 1440774.Y900_003135 1.9e-41 176.0 Mycobacteriaceae Bacteria 239V7@1762,2EA7C@1,2IJPP@201174,334C0@2 NA|NA|NA S Domain of unknown function (DUF5134) OLIIENHM_00306 1440774.Y900_003140 3.2e-206 724.9 Mycobacteriaceae GO:0008150,GO:0040007 ko:K02351,ko:K07245 ko00000,ko02000 9.B.62.1 Bacteria 233IV@1762,2GKIR@201174,COG3336@1,COG3336@2 NA|NA|NA P CytoChrome c oxidase Caa3 assembly factor OLIIENHM_00307 931627.MycrhDRAFT_6859 1.1e-11 75.5 Mycobacteriaceae copZ ko:K07213 ko04978,map04978 ko00000,ko00001 Bacteria 23B7Q@1762,2GSGA@201174,COG2608@1,COG2608@2 NA|NA|NA P heavy metal OLIIENHM_00308 931627.MycrhDRAFT_6858 0.0 1080.5 Mycobacteriaceae ctpA GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 3.6.3.54 ko:K12949,ko:K17686 ko01524,ko04016,map01524,map04016 R00086 RC00002 ko00000,ko00001,ko01000 3.A.3,3.A.3.5 Bacteria 232VV@1762,2GIRF@201174,COG2217@1,COG2217@2 NA|NA|NA P ATPase, P-type (transporting), HAD superfamily, subfamily IC OLIIENHM_00309 1122138.AQUZ01000023_gene7938 2.5e-33 149.4 Propionibacteriales Bacteria 2GMFE@201174,4DRMT@85009,COG0589@1,COG0589@2 NA|NA|NA T Universal stress protein family OLIIENHM_00310 931627.MycrhDRAFT_4802 1.4e-96 359.8 Mycobacteriaceae ppiB 5.2.1.8 ko:K01802,ko:K03768 ko00000,ko01000,ko03110 Bacteria 234XQ@1762,2GVSC@201174,COG0652@1,COG0652@2 NA|NA|NA O Peptidyl-prolyl cis-trans isomerase OLIIENHM_00311 1440774.Y900_001650 6.3e-109 400.6 Mycobacteriaceae ppiB GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0031224,GO:0031226,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0140096,GO:1901564 5.2.1.8 ko:K01802,ko:K03768 ko00000,ko01000,ko03110 Bacteria 233PA@1762,2GN8G@201174,COG0652@1,COG0652@2 NA|NA|NA O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides OLIIENHM_00312 710421.Mycch_2318 2.3e-103 381.7 Mycobacteriaceae ycbL 3.1.2.6 ko:K01069 ko00620,map00620 R01736 RC00004,RC00137 ko00000,ko00001,ko01000 Bacteria 233GV@1762,2GJU0@201174,COG0491@1,COG0491@2 NA|NA|NA S Zn-dependent OLIIENHM_00313 1440774.Y900_001640 2.6e-209 734.6 Mycobacteriaceae hisS GO:0003674,GO:0003824,GO:0004812,GO:0004821,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006427,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iE2348C_1286.E2348C_2797,iECNA114_1301.ECNA114_2592,iECSF_1327.ECSF_2358 Bacteria 23473@1762,2GIYJ@201174,COG0124@1,COG0124@2 NA|NA|NA J histidyl-tRNA synthetase OLIIENHM_00314 931627.MycrhDRAFT_4808 2.8e-28 131.7 Mycobacteriaceae Bacteria 239M4@1762,2A1AM@1,2IKF6@201174,30PH9@2 NA|NA|NA OLIIENHM_00315 1370120.AUWR01000056_gene2975 2.1e-30 139.0 Mycobacteriaceae GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 Bacteria 239Z1@1762,2AVKT@1,2IN1C@201174,31MDJ@2 NA|NA|NA OLIIENHM_00316 1440774.Y900_001540 2.2e-125 455.3 Mycobacteriaceae ypfJ GO:0005575,GO:0005576 ko:K07054 ko00000 Bacteria 233JU@1762,2H3UT@201174,COG2321@1,COG2321@2 NA|NA|NA S Putative neutral zinc metallopeptidase OLIIENHM_00317 487521.OCU_32720 6.2e-297 1026.2 Mycobacteriaceae aspS GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 Bacteria 234BZ@1762,2GJHU@201174,COG0173@1,COG0173@2 NA|NA|NA J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) OLIIENHM_00318 1440774.Y900_001495 2.8e-137 495.4 Mycobacteriaceae Bacteria 233AS@1762,2GN0Y@201174,COG1020@1,COG1020@2 NA|NA|NA Q D-alanine [D-alanyl carrier protein] ligase activity OLIIENHM_00319 931627.MycrhDRAFT_4860 2.5e-56 225.3 Mycobacteriaceae Bacteria 239QU@1762,2BG05@1,2IJGD@201174,31JIR@2 NA|NA|NA S Mycobacterium membrane protein OLIIENHM_00320 931627.MycrhDRAFT_4861 0.0 1437.2 Mycobacteriaceae ko:K06994 ko00000 Bacteria 232PC@1762,2GKX6@201174,COG2409@1,COG2409@2 NA|NA|NA S transport protein OLIIENHM_00322 1160137.KB907307_gene752 1.2e-53 217.6 Nocardiaceae Bacteria 2HFNF@201174,4G76C@85025,COG5479@1,COG5479@2 NA|NA|NA M LGFP repeat OLIIENHM_00324 1068978.AMETH_3304 1.8e-72 278.9 Pseudonocardiales Bacteria 2HYI1@201174,4EAN7@85010,COG1309@1,COG1309@2 NA|NA|NA K WHG domain OLIIENHM_00325 1174684.EBMC1_03764 1.1e-37 162.5 Sphingomonadales Bacteria 1N4F0@1224,2DRRT@1,2K7DV@204457,2UECN@28211,32URI@2 NA|NA|NA OLIIENHM_00326 164757.Mjls_4415 4.4e-83 314.3 Mycobacteriaceae 2.5.1.105 ko:K04088,ko:K06897 ko00790,map00790 M00742 R10339 RC00121 ko00000,ko00001,ko00002,ko01000 Bacteria 236Y9@1762,2GQJJ@201174,COG0053@1,COG0053@2 NA|NA|NA P Cation efflux family OLIIENHM_00327 710421.Mycch_1475 4.1e-114 417.5 Mycobacteriaceae ahpC 1.11.1.15 ko:K03386 ko04214,map04214 ko00000,ko00001,ko01000,ko04147 Bacteria 234SP@1762,2GM74@201174,COG0450@1,COG0450@2 NA|NA|NA O Alkyl hydroperoxide reductase OLIIENHM_00328 1123517.JOMR01000001_gene86 4.1e-44 184.5 Thiotrichales ftnA GO:0003674,GO:0003824,GO:0004322,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0008152,GO:0008199,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016491,GO:0016722,GO:0016724,GO:0019725,GO:0030003,GO:0033554,GO:0042221,GO:0042592,GO:0042802,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071241,GO:0071248,GO:0071281,GO:0097577,GO:0098771 1.16.3.2 ko:K02217,ko:K02255 ko00000,ko01000 Bacteria 1R9ZC@1224,1RYVB@1236,4617E@72273,COG1528@1,COG1528@2 NA|NA|NA P Iron-storage protein OLIIENHM_00329 246196.MSMEI_5271 2.4e-181 641.7 Mycobacteriaceae efeN ko:K16301 ko00000,ko01000,ko02000 2.A.108.2.3 Bacteria 232Z9@1762,2GIUB@201174,COG2837@1,COG2837@2 NA|NA|NA P Dyp-type peroxidase family OLIIENHM_00330 1370125.AUWT01000050_gene2085 2.2e-162 578.6 Mycobacteriaceae ycdO GO:0000041,GO:0006810,GO:0006811,GO:0006812,GO:0006826,GO:0008150,GO:0015684,GO:0030001,GO:0051179,GO:0051234,GO:0070838,GO:0072511 ko:K07224 ko00000,ko02000 2.A.108.2.3 Bacteria 235KZ@1762,2GJPY@201174,COG2822@1,COG2822@2,COG4454@1,COG4454@2 NA|NA|NA P periplasmic lipoprotein involved in iron transport OLIIENHM_00331 931627.MycrhDRAFT_0723 1.9e-113 415.6 Mycobacteriaceae efeU ko:K07243 ko00000,ko02000 2.A.108.1,2.A.108.2 Bacteria 235WY@1762,2GJ22@201174,COG0672@1,COG0672@2 NA|NA|NA P Iron permease FTR1 OLIIENHM_00332 1323361.JPOC01000092_gene1001 1.4e-48 199.9 Nocardiaceae Bacteria 2E6J0@1,2HEIF@201174,33163@2,4FUHF@85025 NA|NA|NA S Protein of unknown function (DUF2470) OLIIENHM_00333 931627.MycrhDRAFT_3188 8.3e-45 186.8 Mycobacteriaceae Bacteria 23A3V@1762,2BVHN@1,2INJM@201174,34748@2 NA|NA|NA S F420H(2)-dependent quinone reductase OLIIENHM_00335 1347342.BN863_22460 1.2e-20 106.7 Bacteria lidJ ko:K03611 ko00000,ko03110 5.A.2.1 Bacteria COG1495@1,COG1495@2 NA|NA|NA O protein disulfide oxidoreductase activity OLIIENHM_00336 1123258.AQXZ01000019_gene2670 1.2e-117 429.9 Nocardiaceae phaC2 ko:K03821 ko00650,map00650 R04254 RC00004 ko00000,ko00001,ko01000 Bacteria 2GP7I@201174,4G10I@85025,COG3243@1,COG3243@2 NA|NA|NA I synthetase OLIIENHM_00337 1265310.CCBD010000065_gene909 2.1e-70 272.3 Mycobacteriaceae ko:K01446 R04112 RC00064,RC00141 ko00000 Bacteria 236UN@1762,2GJ19@201174,COG3876@1,COG3876@2 NA|NA|NA S N-acetylmuramoyl-L-alanine amidase OLIIENHM_00338 882086.SacxiDRAFT_3821 4.4e-106 391.3 Pseudonocardiales 1.6.5.5 ko:K00344 ko00000,ko01000 Bacteria 2GK40@201174,4E1Z5@85010,COG0604@1,COG0604@2 NA|NA|NA C Zinc-binding dehydrogenase OLIIENHM_00339 931627.MycrhDRAFT_3480 1.3e-59 236.1 Mycobacteriaceae Bacteria 233G7@1762,2GMS2@201174,COG2318@1,COG2318@2 NA|NA|NA S Protein of unknown function (DUF664) OLIIENHM_00340 1440774.Y900_016465 5.3e-145 520.4 Mycobacteriaceae ppk2 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008976,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0044237 2.7.4.1 ko:K22468 ko00190,ko03018,map00190,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 2334P@1762,2GKRN@201174,COG2326@1,COG2326@2 NA|NA|NA S polyphosphate kinase OLIIENHM_00343 208444.JNYY01000033_gene5849 1.8e-61 243.4 Pseudonocardiales cya 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 Bacteria 2GN02@201174,4E1TB@85010,COG2114@1,COG2114@2 NA|NA|NA T Adenylate cyclase regulatory domain OLIIENHM_00344 875328.JDM601_3584 1.1e-43 182.6 Mycobacteriaceae Bacteria 239JV@1762,2AHT8@1,2IMSB@201174,3185S@2 NA|NA|NA OLIIENHM_00345 875328.JDM601_3585 2.5e-234 818.1 Mycobacteriaceae kch Bacteria 237N6@1762,2HX5T@201174,COG0569@1,COG0569@2,COG1226@1,COG1226@2 NA|NA|NA P TrkA-N domain OLIIENHM_00346 350058.Mvan_3505 2.9e-241 842.8 Mycobacteriaceae engXCA 3.2.1.14,3.2.1.4 ko:K01179,ko:K01183,ko:K20628 ko00500,ko00520,ko01100,map00500,map00520,map01100 R01206,R02334,R06200,R11307,R11308 RC00467 ko00000,ko00001,ko01000 GH18,GH5,GH9 Bacteria 2384A@1762,2GJTU@201174,COG2730@1,COG2730@2,COG3469@1,COG3469@2 NA|NA|NA G Belongs to the glycosyl hydrolase 18 family OLIIENHM_00347 1209984.BN978_02752 3.3e-132 478.4 Mycobacteriaceae Bacteria 237GS@1762,2GP6W@201174,COG1835@1,COG1835@2 NA|NA|NA I Acyltransferase family OLIIENHM_00348 931627.MycrhDRAFT_5164 4.7e-12 79.3 Mycobacteriaceae Bacteria 23CSQ@1762,2B6RK@1,2H2H1@201174,31ZQJ@2 NA|NA|NA OLIIENHM_00349 525368.HMPREF0591_2754 5.7e-182 643.7 Mycobacteriaceae yagA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 ko:K07497 ko00000 Bacteria 233GJ@1762,2GJ3V@201174,COG2801@1,COG2801@2 NA|NA|NA L Integrase core domain OLIIENHM_00350 318424.EU78_01780 4.4e-53 214.2 Bacteria Bacteria COG4639@1,COG4639@2 NA|NA|NA Q AAA domain OLIIENHM_00351 318424.EU78_01775 9.7e-89 333.6 Mycobacteriaceae Bacteria 23ACX@1762,2DDWH@1,2IP6U@201174,2ZJKR@2 NA|NA|NA OLIIENHM_00352 47839.CCAU010000019_gene3315 2.1e-38 164.9 Mycobacteriaceae istB Bacteria 234SX@1762,2H714@201174,COG1484@1,COG1484@2 NA|NA|NA L IstB-like ATP binding protein OLIIENHM_00353 1440774.Y900_006920 6.6e-151 540.0 Mycobacteriaceae sdhA GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0043436,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071704,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0072350,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 iE2348C_1286.E2348C_0603,iJN746.PP_4191,iPC815.YPO1111 Bacteria 2363U@1762,2GJ45@201174,COG1053@1,COG1053@2 NA|NA|NA C Succinate dehydrogenase flavoprotein subunit OLIIENHM_00354 1440774.Y900_006925 4.1e-131 474.2 Mycobacteriaceae sdhB GO:0000104,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0022904,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0048037,GO:0051536,GO:0051537,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072350,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.3.5.1,1.3.5.4 ko:K00240 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 e_coli_core.b0724,iAF1260.b0724,iBWG_1329.BWG_0583,iEC042_1314.EC042_0742,iECDH10B_1368.ECDH10B_0791,iECDH1ME8569_1439.ECDH1ME8569_0683,iECUMN_1333.ECUMN_0802,iEcDH1_1363.EcDH1_2911,iJO1366.b0724,iJR904.b0724,iY75_1357.Y75_RS03765 Bacteria 234MV@1762,2GP9C@201174,COG0479@1,COG0479@2 NA|NA|NA C succinate dehydrogenase OLIIENHM_00355 216594.MMAR_1007 4.3e-54 217.6 Mycobacteriaceae Bacteria 239CU@1762,2IA6R@201174,COG1510@1,COG1510@2 NA|NA|NA K regulation of RNA biosynthetic process OLIIENHM_00356 419947.MRA_0687 8.5e-59 233.0 Mycobacteriaceae mmpS5 GO:0005575,GO:0005576 Bacteria 238V8@1762,2BG05@1,2IG7K@201174,329W4@2 NA|NA|NA S membrane OLIIENHM_00357 419947.MRA_0686 0.0 1296.2 Mycobacteriaceae mmpL5 GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944 ko:K06994 ko00000 Bacteria 232PC@1762,2GKX6@201174,COG1033@1,COG1033@2,COG2409@1,COG2409@2 NA|NA|NA S transport protein OLIIENHM_00358 1440774.Y900_007005 6.8e-241 839.7 Mycobacteriaceae prr_1 1.2.1.8 ko:K00130 ko00260,ko01100,map00260,map01100 M00555 R02565,R02566 RC00080 ko00000,ko00001,ko00002,ko01000 Bacteria 232XE@1762,2GIWZ@201174,COG1012@1,COG1012@2 NA|NA|NA C Belongs to the aldehyde dehydrogenase family OLIIENHM_00359 1440774.Y900_007010 3.2e-70 271.2 Mycobacteriaceae asnC ko:K03718 ko00000,ko03000 Bacteria 234U6@1762,2GP1P@201174,COG1522@1,COG1522@2 NA|NA|NA K AsnC family OLIIENHM_00360 931627.MycrhDRAFT_0887 4.2e-248 863.6 Mycobacteriaceae bioA Bacteria 232N3@1762,2GKF6@201174,COG0161@1,COG0161@2 NA|NA|NA E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family OLIIENHM_00361 710686.Mycsm_01194 6.7e-131 473.8 Mycobacteriaceae 4.3.3.2 ko:K01757 ko00901,ko01100,ko01110,map00901,map01100,map01110 R03738 RC01072,RC01568 ko00000,ko00001,ko01000 Bacteria 233IT@1762,2GIW1@201174,COG3386@1,COG3386@2 NA|NA|NA G Strictosidine synthase OLIIENHM_00362 931627.MycrhDRAFT_0885 3e-162 578.2 Mycobacteriaceae dac 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 ko00000,ko00001,ko01000,ko01002,ko01011 Bacteria 232K6@1762,2GK3M@201174,COG1686@1,COG1686@2 NA|NA|NA M Belongs to the peptidase S11 family OLIIENHM_00363 931627.MycrhDRAFT_3918 3.6e-175 621.3 Mycobacteriaceae Bacteria 232NV@1762,2GU7G@201174,COG1403@1,COG1403@2 NA|NA|NA V Domain of unknown function (DUF222) OLIIENHM_00364 1172186.KB911478_gene798 3.2e-86 325.1 Mycobacteriaceae yhjD ko:K07058 ko00000 Bacteria 232D6@1762,2GN79@201174,COG1295@1,COG1295@2 NA|NA|NA S PFAM ribonuclease OLIIENHM_00365 1370120.AUWR01000027_gene2482 6.3e-145 520.4 Mycobacteriaceae trpS GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 2330H@1762,2GJ9A@201174,COG0180@1,COG0180@2 NA|NA|NA J Tryptophanyl-tRNA synthetase OLIIENHM_00366 1440774.Y900_008225 9.3e-30 135.6 Mycobacteriaceae mspA GO:0005575,GO:0005618,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 Bacteria 2332W@1762,2AKDY@1,2GMCE@201174,31B57@2 NA|NA|NA S PFAM MspA OLIIENHM_00367 258533.BN977_01455 7.3e-168 596.7 Mycobacteriaceae dapC Bacteria 2334K@1762,2GJMI@201174,COG0436@1,COG0436@2 NA|NA|NA E Aminotransferase OLIIENHM_00368 262316.MAP_2607c 6.2e-54 216.5 Mycobacteriaceae fdxA ko:K05524 ko00000 Bacteria 239CP@1762,2IKVN@201174,COG1146@1,COG1146@2 NA|NA|NA C ferredoxin OLIIENHM_00369 1122611.KB903974_gene2937 3.5e-31 141.4 Streptosporangiales Bacteria 2GMPH@201174,4EJKB@85012,COG1853@1,COG1853@2 NA|NA|NA S Flavin reductase like domain OLIIENHM_00370 350058.Mvan_5089 1.1e-19 102.1 Mycobacteriaceae pstB 3.6.3.27 ko:K02036 ko02010,map02010 M00222 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 Bacteria 236W9@1762,2GJQ3@201174,COG1117@1,COG1117@2 NA|NA|NA P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system OLIIENHM_00371 1123023.JIAI01000001_gene7612 6.4e-150 537.3 Pseudonocardiales ytfL GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03699 ko00000,ko02042 Bacteria 2GKN5@201174,4E0JB@85010,COG1253@1,COG1253@2 NA|NA|NA S Transporter associated domain OLIIENHM_00372 931627.MycrhDRAFT_0385 1.8e-27 127.9 Mycobacteriaceae phoU GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0022611,GO:0031323,GO:0031324,GO:0032502,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042221,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046677,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 ko:K02039 ko00000 Bacteria 2348H@1762,2GKAD@201174,COG0704@1,COG0704@2 NA|NA|NA P Plays a role in the regulation of phosphate uptake OLIIENHM_00374 1440774.Y900_002535 8.7e-150 536.6 Mycobacteriaceae GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 232W5@1762,2GJ78@201174,COG2267@1,COG2267@2 NA|NA|NA I Alpha beta hydrolase OLIIENHM_00375 1173264.KI913949_gene3111 1.1e-129 470.3 Oscillatoriales pap Bacteria 1G34U@1117,1H708@1150,COG2326@1,COG2326@2 NA|NA|NA S PFAM Polyphosphate kinase 2 (PPK2) OLIIENHM_00376 1157943.KB892706_gene4234 2.6e-11 74.7 Mycobacteriaceae Bacteria 23B63@1762,2AY2R@1,2GQSE@201174,31Q4I@2 NA|NA|NA OLIIENHM_00377 1120797.KB908278_gene2824 1.1e-49 203.0 Mycobacteriaceae ko:K21472 ko00000,ko01000,ko01002,ko01011 Bacteria 235NC@1762,2IE8I@201174,COG0741@1,COG0741@2 NA|NA|NA M lytic transglycosylase activity OLIIENHM_00379 1440774.Y900_008175 2.2e-104 386.0 Mycobacteriaceae Bacteria 2334Z@1762,2EA6G@1,2GNTV@201174,334B8@2 NA|NA|NA OLIIENHM_00380 931627.MycrhDRAFT_0653 8.9e-55 219.5 Mycobacteriaceae rimJ 2.3.1.128 ko:K03790 ko00000,ko01000,ko03009 Bacteria 233XK@1762,2HAFI@201174,COG1670@1,COG1670@2 NA|NA|NA J acetyltransferase OLIIENHM_00381 931627.MycrhDRAFT_0652 2.1e-187 661.8 Mycobacteriaceae moeA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0018315,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0032324,GO:0034641,GO:0036211,GO:0042040,GO:0042278,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0061599,GO:0070566,GO:0071704,GO:0071944,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 R09735 RC03462 ko00000,ko00001,ko01000 Bacteria 23429@1762,2GJC3@201174,COG0303@1,COG0303@2 NA|NA|NA H Molybdenum cofactor synthesis OLIIENHM_00382 1440774.Y900_008190 3.2e-148 531.2 Mycobacteriaceae galU 2.7.7.9 ko:K00963 ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130 M00129,M00361,M00362,M00549 R00289 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 235MM@1762,2I2EW@201174,COG1210@1,COG1210@2 NA|NA|NA M UDP-glucose pyrophosphorylase OLIIENHM_00383 1298864.AUEQ01000023_gene1394 2.5e-59 235.3 Mycobacteriaceae fthC 6.3.3.2 ko:K01934 ko00670,ko01100,map00670,map01100 R02301 RC00183 ko00000,ko00001,ko01000 Bacteria 238KT@1762,2IKWR@201174,COG0212@1,COG0212@2 NA|NA|NA H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family OLIIENHM_00384 1209984.BN978_05759 2.8e-27 127.9 Mycobacteriaceae fmdB Bacteria 23AJP@1762,2IQHE@201174,COG2331@1,COG2331@2 NA|NA|NA S regulatory protein, FmdB family OLIIENHM_00385 931627.MycrhDRAFT_0647 5.8e-67 260.8 Mycobacteriaceae cpaB ko:K02279 ko00000,ko02035,ko02044 Bacteria 238MI@1762,2GQJH@201174,COG3745@1,COG3745@2 NA|NA|NA U Flagellar basal body P-ring biosynthesis protein OLIIENHM_00386 710687.KI912270_gene659 9.9e-44 183.0 Mycobacteriaceae mscL GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066 ko:K03282 ko00000,ko02000 1.A.22.1 Bacteria 2391B@1762,2IQDN@201174,COG1970@1,COG1970@2 NA|NA|NA M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell OLIIENHM_00387 1440774.Y900_008225 9.3e-30 135.6 Mycobacteriaceae mspA GO:0005575,GO:0005618,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 Bacteria 2332W@1762,2AKDY@1,2GMCE@201174,31B57@2 NA|NA|NA S PFAM MspA OLIIENHM_00388 931627.MycrhDRAFT_0183 3.7e-93 347.8 Mycobacteriaceae cah GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0008270,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043169,GO:0046872,GO:0046914 4.2.1.1 ko:K01673 ko00910,map00910 R00132,R10092 RC02807 ko00000,ko00001,ko01000 Bacteria 232FK@1762,2GT5H@201174,COG0288@1,COG0288@2 NA|NA|NA P reversible hydration of carbon dioxide OLIIENHM_00389 931627.MycrhDRAFT_0184 5.3e-102 377.5 Mycobacteriaceae Bacteria 23F4P@1762,2E5CN@1,2GM9T@201174,3304R@2 NA|NA|NA OLIIENHM_00390 1440774.Y900_010610 1.5e-179 635.6 Mycobacteriaceae disA 2.7.7.85 ko:K07067 ko00000,ko01000 Bacteria 235JS@1762,2GJ41@201174,COG1623@1,COG1623@2 NA|NA|NA L Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process OLIIENHM_00391 931627.MycrhDRAFT_0186 3.9e-176 624.4 Mycobacteriaceae radA GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 ko:K04485 ko00000,ko03400 Bacteria 232KD@1762,2GMQ0@201174,COG1066@1,COG1066@2 NA|NA|NA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function OLIIENHM_00392 1440774.Y900_010600 7.9e-51 206.8 Mycobacteriaceae lpqE GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 Bacteria 236BV@1762,2IFHN@201174,COG2847@1,COG2847@2 NA|NA|NA S Copper chaperone PCu(A)C OLIIENHM_00393 246196.MSMEI_5917 5.6e-83 313.5 Mycobacteriaceae carD GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0040007,GO:0042594,GO:0044419,GO:0050896,GO:0051704,GO:0051716,GO:0071496 ko:K07736 ko00000,ko03000 Bacteria 234B7@1762,2GKSU@201174,COG1329@1,COG1329@2 NA|NA|NA K transcription factor CarD OLIIENHM_00394 1440774.Y900_010590 7.1e-89 333.6 Mycobacteriaceae ispD GO:0000166,GO:0000287,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016114,GO:0016740,GO:0016772,GO:0016779,GO:0019103,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044464,GO:0046490,GO:0046872,GO:0046914,GO:0050518,GO:0051483,GO:0051484,GO:0070567,GO:0071704,GO:0071944,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.405,2.7.7.40,2.7.7.60,4.6.1.12 ko:K00991,ko:K12506,ko:K21681 ko00040,ko00900,ko01100,ko01110,ko01130,map00040,map00900,map01100,map01110,map01130 M00096 R01525,R02921,R05633,R05637 RC00002,RC00089,RC01440 ko00000,ko00001,ko00002,ko01000 Bacteria 233H1@1762,2GNHP@201174,COG1211@1,COG1211@2 NA|NA|NA I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) OLIIENHM_00395 931627.MycrhDRAFT_0190 2.2e-71 275.0 Mycobacteriaceae ispF GO:0003674,GO:0003824,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008685,GO:0009058,GO:0009987,GO:0016114,GO:0016829,GO:0016849,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0051483,GO:0071704,GO:1901576 2.1.1.228,2.7.7.60,4.6.1.12 ko:K00554,ko:K01770,ko:K12506 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R00597,R05633,R05637 RC00002,RC00003,RC00334,RC01440 ko00000,ko00001,ko00002,ko01000,ko03016 iNJ661.Rv3581c Bacteria 238S8@1762,2II8H@201174,COG0245@1,COG0245@2 NA|NA|NA I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) OLIIENHM_00396 931627.MycrhDRAFT_0191 3.9e-246 857.1 Mycobacteriaceae cysS GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 235IP@1762,2GJF2@201174,COG0215@1,COG0215@2 NA|NA|NA J Belongs to the class-I aminoacyl-tRNA synthetase family OLIIENHM_00397 931627.MycrhDRAFT_0192 4.9e-144 517.3 Mycobacteriaceae rlmB GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.185 ko:K03218 ko00000,ko01000,ko03009 Bacteria 234QS@1762,2GJMR@201174,COG0566@1,COG0566@2 NA|NA|NA J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family OLIIENHM_00398 931627.MycrhDRAFT_0195 2.3e-130 471.9 Mycobacteriaceae Bacteria 234N4@1762,2GMFQ@201174,COG2220@1,COG2220@2 NA|NA|NA S Zn-dependent hydrolases of the beta-lactamase fold OLIIENHM_00399 1440774.Y900_010560 2.3e-99 368.6 Mycobacteriaceae lamB ko:K07160 ko00000 Bacteria 236Y1@1762,2GJA1@201174,COG1540@1,COG1540@2 NA|NA|NA S Belongs to the UPF0271 (lamB) family OLIIENHM_00400 1157943.KB892705_gene3914 4.1e-100 371.3 Mycobacteriaceae znuB ko:K02075,ko:K09816 ko02010,map02010 M00242,M00244 ko00000,ko00001,ko00002,ko02000 3.A.1.15,3.A.1.15.3,3.A.1.15.5 Bacteria 2353C@1762,2GJ7H@201174,COG1108@1,COG1108@2 NA|NA|NA P ABC 3 transport family OLIIENHM_00401 1341646.CBMO010000130_gene3122 1.3e-89 336.3 Mycobacteriaceae znuC ko:K02074,ko:K09817 ko02010,map02010 M00242,M00244 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.15,3.A.1.15.3,3.A.1.15.5 Bacteria 235D4@1762,2GP3A@201174,COG1121@1,COG1121@2 NA|NA|NA P ABC transporter OLIIENHM_00402 262316.MAP_3776c 7.4e-90 337.0 Mycobacteriaceae ko:K02077,ko:K09815 ko02010,map02010 M00242,M00244 ko00000,ko00001,ko00002,ko02000 3.A.1.15,3.A.1.15.3,3.A.1.15.5 Bacteria 233DR@1762,2GM1K@201174,COG0803@1,COG0803@2 NA|NA|NA P periplasmic solute binding protein OLIIENHM_00403 931627.MycrhDRAFT_0202 1.8e-100 372.1 Mycobacteriaceae kstR GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042802,GO:0042803,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141 ko:K22107 ko00000,ko03000 Bacteria 233VJ@1762,2GMPD@201174,COG1309@1,COG1309@2 NA|NA|NA K Transcriptional regulator OLIIENHM_00404 1440774.Y900_010525 3.1e-298 1030.8 Mycobacteriaceae fadE34 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 2333N@1762,2GKVN@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_00405 216594.MMAR_5066 2.9e-34 151.0 Mycobacteriaceae hmp GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0006066,GO:0006629,GO:0006643,GO:0006664,GO:0006706,GO:0006707,GO:0006950,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008610,GO:0009056,GO:0009058,GO:0009247,GO:0009273,GO:0009405,GO:0009628,GO:0009987,GO:0016042,GO:0016125,GO:0016127,GO:0016491,GO:0016705,GO:0016709,GO:0036094,GO:0036200,GO:0036293,GO:0042546,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044282,GO:0044419,GO:0046164,GO:0046467,GO:0047086,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051409,GO:0051536,GO:0051537,GO:0051540,GO:0051704,GO:0055114,GO:0070482,GO:0071554,GO:0071704,GO:0071766,GO:0071840,GO:0071949,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1901576,GO:1901615,GO:1901616,GO:1902652,GO:1903509 1.14.13.142 ko:K02613,ko:K15983 ko00360,ko00984,ko01100,ko01120,map00360,map00984,map01100,map01120 R09838,R09860 RC02690,RC02691 ko00000,ko00001,ko01000 Bacteria 233A1@1762,2GKGS@201174,COG1018@1,COG1018@2 NA|NA|NA C COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 OLIIENHM_00406 931627.MycrhDRAFT_0205 2.9e-194 684.5 Mycobacteriaceae hsaA GO:0000166,GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006066,GO:0006629,GO:0006694,GO:0006706,GO:0006707,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008610,GO:0009056,GO:0009058,GO:0016020,GO:0016042,GO:0016125,GO:0016127,GO:0016491,GO:0016705,GO:0016712,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044110,GO:0044116,GO:0044117,GO:0044238,GO:0044281,GO:0044282,GO:0044403,GO:0044419,GO:0044464,GO:0046164,GO:0048037,GO:0050660,GO:0050662,GO:0051704,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:1901265,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901575,GO:1901576,GO:1901615,GO:1901616,GO:1902652 1.14.14.12 ko:K16047 ko00984,ko01100,ko01120,map00984,map01100,map01120 R09819 RC00236 ko00000,ko00001,ko01000 Bacteria 234WE@1762,2GMKM@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_00407 1150599.MPHLEI_13116 1.9e-148 531.9 Mycobacteriaceae hsaD GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016787,GO:0016822,GO:0016823,GO:0030312,GO:0034820,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944 3.7.1.17 ko:K16050 ko00984,ko01100,ko01120,ko01220,map00984,map01100,map01120,map01220 R09883 RC02018,RC02740 ko00000,ko00001,ko01000 Bacteria 232DY@1762,2H6J4@201174,COG2267@1,COG2267@2 NA|NA|NA I Alpha beta hydrolase OLIIENHM_00408 419947.MRA_3607 1.9e-156 558.5 Mycobacteriaceae hsaC GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006066,GO:0006629,GO:0006706,GO:0006707,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0009056,GO:0009405,GO:0010033,GO:0014070,GO:0016042,GO:0016125,GO:0016127,GO:0016491,GO:0016701,GO:0016702,GO:0033993,GO:0036314,GO:0042221,GO:0043167,GO:0043169,GO:0044238,GO:0044281,GO:0044282,GO:0044419,GO:0046164,GO:0046872,GO:0046914,GO:0047071,GO:0050896,GO:0051213,GO:0051704,GO:0055114,GO:0070723,GO:0071704,GO:0097305,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616,GO:1901700,GO:1902652 1.13.11.25 ko:K16049 ko00984,ko01100,ko01120,ko01220,map00984,map01100,map01120,map01220 R04597 RC01610 ko00000,ko00001,ko01000 Bacteria 232N5@1762,2GM8H@201174,COG0346@1,COG0346@2 NA|NA|NA E Glyoxalase bleomycin resistance protein dioxygenase OLIIENHM_00409 216594.MMAR_5062 3.8e-91 340.9 Mycobacteriaceae hsaB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006066,GO:0006629,GO:0006694,GO:0006706,GO:0006707,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008610,GO:0009056,GO:0009058,GO:0016042,GO:0016125,GO:0016127,GO:0016491,GO:0016645,GO:0016646,GO:0036094,GO:0042602,GO:0043167,GO:0043168,GO:0044238,GO:0044281,GO:0044282,GO:0046164,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901575,GO:1901576,GO:1901615,GO:1901616,GO:1902652 ko:K16048 ko00984,ko01100,map00984,map01100 R09819 RC00236 ko00000,ko00001,ko01000 Bacteria 235SP@1762,2GPJS@201174,COG1853@1,COG1853@2 NA|NA|NA S COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family OLIIENHM_00410 1209984.BN978_03005 2.4e-104 385.2 Mycobacteriaceae ytpA GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0008150,GO:0008152,GO:0016020,GO:0016298,GO:0016787,GO:0016788,GO:0044238,GO:0071704 3.1.1.5 ko:K01048 ko00564,map00564 ko00000,ko00001,ko01000 Bacteria 2348X@1762,2GK6S@201174,COG2267@1,COG2267@2 NA|NA|NA I Serine aminopeptidase, S33 OLIIENHM_00411 931627.MycrhDRAFT_0210 2.3e-180 638.3 Mycobacteriaceae aspB Bacteria 233AF@1762,2GJ7R@201174,COG0436@1,COG0436@2 NA|NA|NA E Aminotransferase OLIIENHM_00412 931627.MycrhDRAFT_0211 2.5e-105 388.7 Mycobacteriaceae fadE33 Bacteria 234NN@1762,2GKVN@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_00413 1449048.JQKU01000006_gene5007 2.6e-37 161.0 Mycobacteriaceae sufE ko:K02426,ko:K07125 ko00000 Bacteria 239IY@1762,2IMBF@201174,COG2166@1,COG2166@2 NA|NA|NA S Fe-S metabolism associated OLIIENHM_00414 931627.MycrhDRAFT_6660 2.2e-42 179.1 Mycobacteriaceae 3.6.1.27 ko:K19302 ko00550,map00550 R05627 RC00002 ko00000,ko00001,ko01000,ko01011 Bacteria 23CBG@1762,2GZP5@201174,COG0671@1,COG0671@2 NA|NA|NA I PAP2 superfamily OLIIENHM_00415 680646.RMDY18_15470 8e-79 301.2 Micrococcaceae Bacteria 1WC72@1268,2EJ0Q@1,2GUPE@201174,33CRW@2 NA|NA|NA OLIIENHM_00416 1440774.Y900_008740 1.3e-254 885.6 Mycobacteriaceae ndvA ko:K06147 ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 2357B@1762,2GITR@201174,COG1132@1,COG1132@2 NA|NA|NA V ABC transporter OLIIENHM_00417 1440774.Y900_008745 1.1e-272 945.7 Mycobacteriaceae ko:K06147 ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 232Q7@1762,2GITR@201174,COG1132@1,COG1132@2 NA|NA|NA V ABC transporter OLIIENHM_00418 710685.MycrhN_2665 3.4e-121 441.0 Mycobacteriaceae Bacteria 232GG@1762,2GNFH@201174,COG0745@1,COG0745@2 NA|NA|NA K transcriptional OLIIENHM_00419 1440774.Y900_008755 1.3e-203 715.7 Mycobacteriaceae Bacteria 2329F@1762,2H2N3@201174,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor OLIIENHM_00420 1385520.N802_12955 4.9e-29 135.2 Intrasporangiaceae rplD GO:0000027,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003700,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0005886,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008428,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030234,GO:0030312,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032069,GO:0032074,GO:0032268,GO:0032269,GO:0032991,GO:0032993,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0042788,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060698,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0065003,GO:0065007,GO:0065009,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:0098772,GO:0140110,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990904,GO:2000112,GO:2000113,GO:2001141 ko:K02879,ko:K02926,ko:K16193 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2GRQK@201174,4FHXP@85021,COG0088@1,COG0088@2,COG0203@1,COG0203@2,COG5263@1,COG5263@2 NA|NA|NA J repeat protein OLIIENHM_00421 931627.MycrhDRAFT_4911 1e-263 915.6 Mycobacteriaceae carB GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 iAF1260.b0033,iBWG_1329.BWG_0031,iECDH10B_1368.ECDH10B_0034,iECDH1ME8569_1439.ECDH1ME8569_0031,iECUMN_1333.ECUMN_0034,iEcDH1_1363.EcDH1_3566,iJN746.PP_4723,iJO1366.b0033,iJR904.b0033,iPC815.YPO0482,iY75_1357.Y75_RS00170,iYL1228.KPN_00041 Bacteria 233XC@1762,2GK5N@201174,COG0458@1,COG0458@2 NA|NA|NA F Carbamoyl-phosphate synthetase ammonia chain OLIIENHM_00422 931627.MycrhDRAFT_4912 1.6e-112 412.5 Mycobacteriaceae pyrF GO:0003674,GO:0003824,GO:0004590,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.10,4.1.1.23 ko:K01591,ko:K13421 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00051 R00965,R01870,R08231 RC00063,RC00409,RC00611 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS17585 Bacteria 233BU@1762,2GKWK@201174,COG0284@1,COG0284@2 NA|NA|NA F Belongs to the OMP decarboxylase family. Type 2 subfamily OLIIENHM_00423 710687.KI912270_gene1420 7.3e-44 183.0 Mycobacteriaceae mihF 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 239WW@1762,2IKPU@201174,COG0099@1,COG0099@2 NA|NA|NA J integration host factor OLIIENHM_00424 1440774.Y900_001150 6.3e-79 300.4 Mycobacteriaceae gmk GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004017,GO:0004385,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019002,GO:0019003,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0042278,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046872,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:0097159,GO:0097367,GO:1901068,GO:1901135,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901576,GO:1901657 2.7.4.23,2.7.4.8 ko:K00942,ko:K05774 ko00030,ko00230,ko01100,map00030,map00230,map01100 M00050 R00332,R02090,R06836 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 233EZ@1762,2I4FH@201174,COG3709@1,COG3709@2 NA|NA|NA F Essential for recycling GMP and indirectly, cGMP OLIIENHM_00425 931627.MycrhDRAFT_4917 8.3e-45 186.0 Mycobacteriaceae rpoZ GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 Bacteria 23A0K@1762,2IQHU@201174,COG1758@1,COG1758@2 NA|NA|NA K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits OLIIENHM_00426 931627.MycrhDRAFT_4918 3.8e-192 677.6 Mycobacteriaceae coaBC GO:0003674,GO:0003824,GO:0004633,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016020,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 Bacteria 232PQ@1762,2GJGJ@201174,COG0452@1,COG0452@2 NA|NA|NA H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine OLIIENHM_00427 1150599.MPHLEI_20579 1.3e-200 705.7 Mycobacteriaceae metK GO:0003674,GO:0003824,GO:0004478,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0016740,GO:0016765,GO:0019899,GO:0030312,GO:0035375,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 Bacteria 233PG@1762,2GJ4U@201174,COG0192@1,COG0192@2 NA|NA|NA H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme OLIIENHM_00428 931627.MycrhDRAFT_4922 4.2e-33 147.5 Mycobacteriaceae Bacteria 23DJH@1762,2A2SI@1,2H4RQ@201174,320WH@2 NA|NA|NA S Haemophore, haem-binding OLIIENHM_00429 1440774.Y900_001115 2.9e-139 501.5 Mycobacteriaceae lipI ko:K01066 ko00000,ko01000 Bacteria 233P8@1762,2GJYR@201174,COG0657@1,COG0657@2 NA|NA|NA I PFAM Alpha beta hydrolase OLIIENHM_00430 1440774.Y900_001110 1.8e-73 282.3 Mycobacteriaceae Bacteria 235QS@1762,2I157@201174,COG3714@1,COG3714@2 NA|NA|NA S membrane OLIIENHM_00431 1268303.RHODMAR_2285 3.2e-65 255.0 Nocardiaceae Bacteria 2IFH7@201174,4FV2X@85025,COG2304@1,COG2304@2 NA|NA|NA S von Willebrand factor (vWF) type A domain OLIIENHM_00432 931627.MycrhDRAFT_4925 0.0 1085.9 Mycobacteriaceae priA GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 ko:K04066 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 234I5@1762,2GKES@201174,COG1198@1,COG1198@2 NA|NA|NA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA OLIIENHM_00433 931627.MycrhDRAFT_4926 6.3e-204 717.2 Mycobacteriaceae yciQ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 233E7@1762,2GNW7@201174,COG4907@1,COG4907@2 NA|NA|NA S Predicted membrane protein (DUF2207) OLIIENHM_00434 931627.MycrhDRAFT_4927 5.6e-68 263.8 Mycobacteriaceae lemA ko:K03744 ko00000 Bacteria 233IX@1762,2GPS4@201174,COG1704@1,COG1704@2 NA|NA|NA S LemA family OLIIENHM_00435 1440774.Y900_001095 2e-137 495.4 Mycobacteriaceae fmt GO:0003674,GO:0003824,GO:0004479,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006418,GO:0006431,GO:0006464,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019752,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.1.176,2.1.2.9 ko:K00604,ko:K03500 ko00670,ko00970,map00670,map00970 R03940 RC00026,RC00165 ko00000,ko00001,ko01000,ko03009 iECABU_c1320.ECABU_c37050,iECUMN_1333.ECUMN_3761,ic_1306.c4048 Bacteria 2349H@1762,2GKH5@201174,COG0223@1,COG0223@2 NA|NA|NA J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus OLIIENHM_00436 931627.MycrhDRAFT_4929 8.3e-198 696.4 Mycobacteriaceae sun GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.176 ko:K03500 ko00000,ko01000,ko03009 Bacteria 235CW@1762,2GM21@201174,COG0144@1,COG0144@2,COG0781@1,COG0781@2 NA|NA|NA JK Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family OLIIENHM_00437 1440774.Y900_001085 6.9e-108 396.7 Mycobacteriaceae rpe GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 Bacteria 233YW@1762,2GJZ9@201174,COG0036@1,COG0036@2 NA|NA|NA G Belongs to the ribulose-phosphate 3-epimerase family OLIIENHM_00438 1440774.Y900_001080 1.7e-142 512.3 Mycobacteriaceae ribD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0016020,GO:0016070,GO:0034641,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 Bacteria 234R1@1762,2GKAX@201174,COG0117@1,COG0117@2,COG1985@1,COG1985@2 NA|NA|NA H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate OLIIENHM_00439 1341646.CBMO010000044_gene4839 2.9e-134 485.0 Mycobacteriaceae ytrE ko:K02003,ko:K09810,ko:K10038 ko02010,map02010 M00227,M00255,M00258 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.125,3.A.1.3.2 Bacteria 233TP@1762,2GJN6@201174,COG1136@1,COG1136@2 NA|NA|NA V ABC transporter OLIIENHM_00440 1209984.BN978_06986 4.2e-128 464.5 Mycobacteriaceae GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009405,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0051704,GO:0071944 ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 234N9@1762,2HNFQ@201174,COG0577@1,COG0577@2 NA|NA|NA V FtsX-like permease family OLIIENHM_00441 931627.MycrhDRAFT_4934 7e-220 770.0 Mycobacteriaceae GO:0003674,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008144,GO:0008150,GO:0009405,GO:0015562,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0051704,GO:0055085,GO:0071944 Bacteria 232N2@1762,2GQFQ@201174,COG0477@1,COG0477@2 NA|NA|NA EGP Major facilitator superfamily OLIIENHM_00442 1440774.Y900_001005 1.4e-82 312.8 Mycobacteriaceae lprG GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008289,GO:0009405,GO:0016020,GO:0030312,GO:0031982,GO:0035091,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043230,GO:0044419,GO:0044421,GO:0044464,GO:0051704,GO:0051861,GO:0071944,GO:0097367,GO:0097691,GO:1903561 ko:K14954 ko05152,map05152 ko00000,ko00001 Bacteria 234TG@1762,2DQVM@1,2I9JA@201174,338Y0@2 NA|NA|NA S (P55) transport triacylglycerides (TAG) across the inner cell membrane into the periplasm and probably ultimately to the outer membrane OLIIENHM_00443 1283299.AUKG01000002_gene4742 5e-36 157.5 Rubrobacteria MA20_27725 Bacteria 2GNNG@201174,4CQUQ@84995,COG0454@1,COG0456@2 NA|NA|NA K Acetyltransferase (GNAT) domain OLIIENHM_00444 931627.MycrhDRAFT_4936 3e-86 324.7 Mycobacteriaceae ribE GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.9,3.5.4.25,4.1.99.12 ko:K00793,ko:K02858,ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00066,R00425,R07281 RC00293,RC00958,RC00960,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS08950 Bacteria 2344A@1762,2GKC5@201174,COG0307@1,COG0307@2 NA|NA|NA H riboflavin synthase alpha OLIIENHM_00445 710421.Mycch_1263 7.8e-27 127.5 Mycobacteriaceae pilY1 3.2.1.4 ko:K01179,ko:K02674 ko00500,ko01100,map00500,map01100 R06200,R11307,R11308 ko00000,ko00001,ko01000,ko02035,ko02044 GH5,GH9 Bacteria 236JM@1762,2IAZN@201174,COG2304@1,COG2304@2,COG3291@1,COG3291@2 NA|NA|NA S Pkd domain containing protein OLIIENHM_00446 931627.MycrhDRAFT_4943 1.1e-226 792.3 Mycobacteriaceae ribBA GO:0005575,GO:0005576,GO:0008150,GO:0040007 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1415 Bacteria 2349C@1762,2GIWJ@201174,COG0108@1,COG0108@2,COG0807@1,COG0807@2 NA|NA|NA H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate OLIIENHM_00447 1120797.KB908255_gene541 5.7e-64 250.4 Mycobacteriaceae ribH GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0040007,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 Bacteria 238JR@1762,2II1Z@201174,COG0054@1,COG0054@2 NA|NA|NA H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin OLIIENHM_00448 47839.CCAU010000009_gene1427 3.6e-36 157.9 Mycobacteriaceae GO:0005575,GO:0005623,GO:0005886,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016020,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 Bacteria 239AM@1762,2E71H@1,2IR72@201174,331K6@2 NA|NA|NA S Bacterial PH domain OLIIENHM_00449 1440774.Y900_000945 0.0 1119.8 Mycobacteriaceae uvrC GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016787,GO:0016788,GO:0030312,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1902494,GO:1905347,GO:1905348,GO:1990391 ko:K03703 ko03420,map03420 ko00000,ko00001,ko03400 Bacteria 2330D@1762,2GIS4@201174,COG0322@1,COG0322@2 NA|NA|NA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision OLIIENHM_00450 1440774.Y900_000940 2.2e-136 491.9 Mycobacteriaceae rapZ GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363 ko:K06958 ko00000,ko03019 Bacteria 233GD@1762,2GMWB@201174,COG1660@1,COG1660@2 NA|NA|NA S Displays ATPase and GTPase activities OLIIENHM_00451 1440774.Y900_000935 6.4e-158 563.5 Mycobacteriaceae ybhK Bacteria 2356E@1762,2GJBW@201174,COG0391@1,COG0391@2 NA|NA|NA S Required for morphogenesis under gluconeogenic growth conditions OLIIENHM_00452 710686.Mycsm_02857 1.2e-164 585.9 Mycobacteriaceae whiA GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0043937,GO:0044464,GO:0050789,GO:0050793,GO:0065007,GO:0071944 ko:K09762 ko00000 Bacteria 234JZ@1762,2GJZU@201174,COG1481@1,COG1481@2 NA|NA|NA K May be required for sporulation OLIIENHM_00453 710687.KI912270_gene1016 9.7e-134 483.0 Mycobacteriaceae Bacteria 237Q2@1762,2GJD2@201174,COG3662@1,COG3662@2 NA|NA|NA S Uncharacterized protein conserved in bacteria (DUF2236) OLIIENHM_00454 710686.Mycsm_02862 4.5e-167 594.0 Mycobacteriaceae gap GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 Bacteria 235EV@1762,2GJK4@201174,COG0057@1,COG0057@2 NA|NA|NA G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family OLIIENHM_00455 1440774.Y900_000910 7.4e-193 679.9 Mycobacteriaceae pgk GO:0003674,GO:0003824,GO:0004618,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.2.3,5.3.1.1 ko:K00927,ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01015,R01512 RC00002,RC00043,RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2348G@1762,2GJC6@201174,COG0126@1,COG0126@2 NA|NA|NA F Belongs to the phosphoglycerate kinase family OLIIENHM_00456 1265310.CCBD010000031_gene1660 6e-127 460.3 Mycobacteriaceae tpiA GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 2.7.2.3,5.3.1.1 ko:K00927,ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01015,R01512 RC00002,RC00043,RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 234GN@1762,2GJXZ@201174,COG0149@1,COG0149@2 NA|NA|NA G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) OLIIENHM_00457 1370121.AUWS01000043_gene1152 9.3e-28 129.0 Mycobacteriaceae secG GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 Bacteria 23AM3@1762,2GR31@201174,COG1314@1,COG1314@2 NA|NA|NA U translocase subunit secG OLIIENHM_00458 1313172.YM304_34140 7.6e-180 637.1 Actinobacteria nfdA_2 Bacteria 2IBQ5@201174,COG1574@1,COG1574@2 NA|NA|NA S Amidohydrolase family OLIIENHM_00459 931627.MycrhDRAFT_4958 1.1e-176 626.3 Mycobacteriaceae Bacteria 232NV@1762,2GU7G@201174,COG1403@1,COG1403@2 NA|NA|NA V Domain of unknown function (DUF222) OLIIENHM_00460 931627.MycrhDRAFT_4959 0.0 1476.8 Mycobacteriaceae ppc GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008964,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0072350 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 iJN678.ppc,iSFV_1184.SFV_4025 Bacteria 236F4@1762,2GKDB@201174,COG2352@1,COG2352@2 NA|NA|NA H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle OLIIENHM_00462 1440774.Y900_000870 1.1e-95 356.3 Mycobacteriaceae pgl GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009051,GO:0009117,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0017057,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0052689,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:1901135,GO:1901360,GO:1901564 3.1.1.31 ko:K01057,ko:K02003 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008,M00258 R02035 RC00537 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1 Bacteria 232FR@1762,2GMQ2@201174,COG0363@1,COG0363@2 NA|NA|NA G 6-phosphogluconolactonase OLIIENHM_00463 931627.MycrhDRAFT_4965 2.2e-136 491.9 Mycobacteriaceae opcA Bacteria 235CT@1762,2GJ1H@201174,COG3429@1,COG3429@2 NA|NA|NA G OpcA protein OLIIENHM_00464 1440774.Y900_000860 3.3e-270 937.2 Mycobacteriaceae zwf GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 iIT341.HP1101 Bacteria 233S5@1762,2GISI@201174,COG0364@1,COG0364@2 NA|NA|NA G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone OLIIENHM_00465 931627.MycrhDRAFT_4967 3.7e-170 604.4 Mycobacteriaceae tal GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 2.2.1.2 ko:K00616 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01827 RC00439,RC00604 ko00000,ko00001,ko00002,ko01000 Bacteria 236CP@1762,2GMF9@201174,COG0176@1,COG0176@2 NA|NA|NA F Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway OLIIENHM_00466 931627.MycrhDRAFT_4968 0.0 1241.1 Mycobacteriaceae tkt GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 Bacteria 234JR@1762,2GJ1K@201174,COG0021@1,COG0021@2 NA|NA|NA G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate OLIIENHM_00467 1440774.Y900_000845 4.4e-140 504.2 Mycobacteriaceae ctaB GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 Bacteria 233AE@1762,2GJMY@201174,COG0109@1,COG0109@2 NA|NA|NA O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group OLIIENHM_00468 1440774.Y900_000840 3.6e-153 547.7 Mycobacteriaceae qor 1.6.5.5 ko:K00344 ko00000,ko01000 Bacteria 2361R@1762,2GKHW@201174,COG0604@1,COG0604@2 NA|NA|NA C NADPH quinone reductase OLIIENHM_00469 931627.MycrhDRAFT_4974 3.6e-126 458.0 Mycobacteriaceae 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 Bacteria 23303@1762,2HI2Z@201174,COG0189@1,COG0189@2 NA|NA|NA HJ ligase activity OLIIENHM_00470 931627.MycrhDRAFT_4975 2.6e-122 445.3 Mycobacteriaceae ctaA ko:K02259 ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714 M00154 R07412 RC00769 ko00000,ko00001,ko00002,ko03029 3.D.4.4 Bacteria 232GU@1762,2GJQX@201174,COG1612@1,COG1612@2 NA|NA|NA O cytochrome oxidase assembly OLIIENHM_00471 1440774.Y900_000825 2.2e-113 415.2 Mycobacteriaceae ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 232VU@1762,2GN6S@201174,COG0842@1,COG0842@2 NA|NA|NA V ABC transporter OLIIENHM_00472 931627.MycrhDRAFT_4979 1.6e-147 528.9 Mycobacteriaceae drrA_2 ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 234CH@1762,2GJBF@201174,COG1131@1,COG1131@2 NA|NA|NA V ABC transporter OLIIENHM_00473 1440774.Y900_000815 2.1e-251 874.8 Mycobacteriaceae GO:0008150,GO:0040007 ko:K14339 ko00000,ko01000,ko01003 Bacteria 232EF@1762,2BVCQ@1,2I46E@201174,32QSS@2 NA|NA|NA S transferase activity, transferring glycosyl groups OLIIENHM_00474 1440774.Y900_000810 9.1e-93 346.7 Mycobacteriaceae sufR Bacteria 2346M@1762,2GN8W@201174,COG2345@1,COG2345@2 NA|NA|NA K regulatory protein OLIIENHM_00476 931627.MycrhDRAFT_3578 3.7e-184 651.0 Mycobacteriaceae acdA 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 Bacteria 233KI@1762,2GIX8@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_00477 931627.MycrhDRAFT_3577 1.2e-123 449.5 Mycobacteriaceae mmsB 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 R05066 RC00099 ko00000,ko00001,ko01000 Bacteria 233BJ@1762,2GNB0@201174,COG2084@1,COG2084@2 NA|NA|NA I Belongs to the 3-hydroxyisobutyrate dehydrogenase family OLIIENHM_00478 1370121.AUWS01000019_gene6767 1.2e-75 289.3 Mycobacteriaceae Bacteria 2357I@1762,2GKZA@201174,COG1846@1,COG1846@2 NA|NA|NA K transcriptional OLIIENHM_00479 1440774.Y900_018305 2.3e-109 401.7 Mycobacteriaceae map GO:0000096,GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006464,GO:0006508,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009066,GO:0009987,GO:0010467,GO:0016020,GO:0016151,GO:0016485,GO:0016787,GO:0019538,GO:0019752,GO:0030145,GO:0035551,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044464,GO:0046872,GO:0046914,GO:0050897,GO:0051604,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901605 3.4.11.18 ko:K01265 ko00000,ko01000,ko01002 Bacteria 232U8@1762,2GKKB@201174,COG0024@1,COG0024@2 NA|NA|NA E Methionine aminopeptidase OLIIENHM_00480 1440774.Y900_018300 4.2e-79 300.8 Mycobacteriaceae adk GO:0000166,GO:0003674,GO:0003824,GO:0004017,GO:0004550,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006144,GO:0006163,GO:0006164,GO:0006165,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009141,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0030554,GO:0032261,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043094,GO:0043101,GO:0043167,GO:0043168,GO:0043173,GO:0044209,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046033,GO:0046390,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 234F8@1762,2GJ7T@201174,COG0563@1,COG0563@2 NA|NA|NA F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism OLIIENHM_00481 1440774.Y900_018295 4.4e-223 780.4 Mycobacteriaceae secY GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5 Bacteria 232W8@1762,2GJ26@201174,COG0201@1,COG0201@2 NA|NA|NA U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently OLIIENHM_00482 47839.CCAU010000004_gene1013 7.1e-84 317.4 Mycobacteriaceae Bacteria 233WR@1762,2GKDZ@201174,COG3315@1,COG3315@2 NA|NA|NA Q Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity OLIIENHM_00483 1440774.Y900_018275 3e-114 418.3 Mycobacteriaceae GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 233WR@1762,2GKDZ@201174,COG3315@1,COG3315@2 NA|NA|NA Q Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity OLIIENHM_00484 931627.MycrhDRAFT_3564 2.6e-239 834.7 Mycobacteriaceae sppA ko:K04773 ko00000,ko01000,ko01002 Bacteria 2358Q@1762,2HQDG@201174,COG0616@1,COG0616@2 NA|NA|NA OU signal peptide peptidase SppA, 67K type OLIIENHM_00485 1122247.C731_1094 2.9e-62 244.6 Mycobacteriaceae rplO GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02876 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 238NI@1762,2II6M@201174,COG0200@1,COG0200@2 NA|NA|NA J Binds to the 23S rRNA OLIIENHM_00486 875328.JDM601_3314 9.6e-21 105.5 Mycobacteriaceae rpmD GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02907 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 23B7P@1762,2GQV0@201174,COG1841@1,COG1841@2 NA|NA|NA J Ribosomal protein L30 OLIIENHM_00487 931627.MycrhDRAFT_3560 2.7e-94 351.7 Mycobacteriaceae rpsE GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990145,GO:1990904 ko:K02988 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 233YI@1762,2GJW8@201174,COG0098@1,COG0098@2 NA|NA|NA J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body OLIIENHM_00488 931627.MycrhDRAFT_3559 4.7e-51 207.2 Mycobacteriaceae rplR GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02881 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 23980@1762,2IKTX@201174,COG0256@1,COG0256@2 NA|NA|NA J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance OLIIENHM_00489 931627.MycrhDRAFT_3558 1.1e-87 329.3 Mycobacteriaceae rplF GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02933 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 232VW@1762,2GK35@201174,COG0097@1,COG0097@2 NA|NA|NA J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center OLIIENHM_00490 1194972.MVAC_07824 1.3e-64 252.3 Mycobacteriaceae rpsH GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 ko:K02994 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 238JP@1762,2IHQZ@201174,COG0096@1,COG0096@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit OLIIENHM_00491 931627.MycrhDRAFT_3556 2.2e-27 127.5 Mycobacteriaceae rpsN GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02954 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 23AM9@1762,2IQ8R@201174,COG0199@1,COG0199@2 NA|NA|NA J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site OLIIENHM_00492 1440774.Y900_018220 7.1e-98 363.2 Mycobacteriaceae rplE GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02931 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 23503@1762,2GJW7@201174,COG0094@1,COG0094@2 NA|NA|NA J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits OLIIENHM_00493 1299327.I546_0490 1.5e-47 195.3 Mycobacteriaceae rplX GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02895 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 23A30@1762,2IKP2@201174,COG0198@1,COG0198@2 NA|NA|NA J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit OLIIENHM_00494 318424.EU78_05625 6.6e-60 236.5 Mycobacteriaceae rplN GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02874 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 239C5@1762,2IHNX@201174,COG0093@1,COG0093@2 NA|NA|NA J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome OLIIENHM_00495 931627.MycrhDRAFT_3552 3e-135 488.0 Mycobacteriaceae pkn1 GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016667,GO:0016670,GO:0018158,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0055114,GO:0071704,GO:0120147,GO:1901564 Bacteria 234GV@1762,2GK9Q@201174,COG1262@1,COG1262@2 NA|NA|NA S Sulfatase-modifying factor enzyme 1 OLIIENHM_00496 258533.BN977_04574 0.0 1346.3 Mycobacteriaceae atsA GO:0000323,GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0004065,GO:0004098,GO:0005488,GO:0005509,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005764,GO:0005766,GO:0005773,GO:0005775,GO:0005783,GO:0005788,GO:0006629,GO:0006643,GO:0006664,GO:0006665,GO:0006687,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0008150,GO:0008152,GO:0008484,GO:0009987,GO:0012505,GO:0016192,GO:0016787,GO:0016788,GO:0030141,GO:0031410,GO:0031974,GO:0031982,GO:0031983,GO:0032940,GO:0034774,GO:0035578,GO:0036230,GO:0042119,GO:0042582,GO:0043167,GO:0043169,GO:0043202,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043299,GO:0043312,GO:0044237,GO:0044238,GO:0044255,GO:0044422,GO:0044424,GO:0044432,GO:0044433,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0046872,GO:0046903,GO:0050896,GO:0051179,GO:0051234,GO:0060205,GO:0070013,GO:0071704,GO:0097708,GO:0099503,GO:1901135,GO:1901564,GO:1903509 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 Bacteria 234H7@1762,2GJ8H@201174,COG3119@1,COG3119@2 NA|NA|NA P Arylsulfatase OLIIENHM_00497 1172186.KB911467_gene1915 7.7e-61 240.0 Mycobacteriaceae mpt63 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 Bacteria 239K8@1762,29WEB@1,2IBXV@201174,30I03@2 NA|NA|NA S Domain of unknown function (DUF1942) OLIIENHM_00498 350058.Mvan_5244 6.4e-178 630.9 Mycobacteriaceae Bacteria 232YB@1762,2DQQ8@1,2IBH6@201174,33823@2 NA|NA|NA OLIIENHM_00499 258533.BN977_04573 3.8e-211 741.1 Mycobacteriaceae Bacteria 235Q9@1762,2GP51@201174,COG1807@1,COG1807@2 NA|NA|NA M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family OLIIENHM_00500 258533.BN977_04572 1.6e-205 722.2 Mycobacteriaceae AtCs1C4 2.4.1.336 ko:K19003,ko:K20327 ko00561,ko01100,ko02024,map00561,map01100,map02024 R02689 RC00005,RC00059 ko00000,ko00001,ko01000,ko01003 GT2 Bacteria 233YH@1762,2GNN5@201174,COG1215@1,COG1215@2 NA|NA|NA M Glycosyl transferase family group 2 OLIIENHM_00501 1150599.MPHLEI_04977 3.2e-129 468.8 Mycobacteriaceae Bacteria 23428@1762,2EYSJ@1,2IC9W@201174,33RZU@2 NA|NA|NA OLIIENHM_00502 258533.BN977_04570 2.6e-171 609.0 Mycobacteriaceae Bacteria 232YB@1762,2DQQ8@1,2IBH6@201174,33823@2 NA|NA|NA OLIIENHM_00504 246196.MSMEI_0461 2.1e-48 199.1 Mycobacteriaceae Bacteria 232UG@1762,2IE0X@201174,COG2197@1,COG2197@2 NA|NA|NA K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain OLIIENHM_00505 700508.D174_10785 5.3e-26 124.0 Mycobacteriaceae rsbW 2.7.11.1 ko:K04757 ko00000,ko01000,ko01001,ko03021 Bacteria 23B26@1762,2GQFJ@201174,COG2172@1,COG2172@2 NA|NA|NA T Histidine kinase-like ATPase domain OLIIENHM_00506 700508.D174_10785 2.5e-28 131.7 Mycobacteriaceae rsbW 2.7.11.1 ko:K04757 ko00000,ko01000,ko01001,ko03021 Bacteria 23B26@1762,2GQFJ@201174,COG2172@1,COG2172@2 NA|NA|NA T Histidine kinase-like ATPase domain OLIIENHM_00507 700508.D174_10790 2.8e-15 87.4 Mycobacteriaceae ko:K04749 ko00000,ko03021 Bacteria 23AHV@1762,2I19W@201174,COG1366@1,COG1366@2 NA|NA|NA T Belongs to the anti-sigma-factor antagonist family OLIIENHM_00509 1440774.Y900_001460 0.0 1820.1 Mycobacteriaceae MA20_16195 GO:0003674,GO:0005198,GO:0005575,GO:0005623,GO:0008150,GO:0009987,GO:0016043,GO:0030115,GO:0030312,GO:0044464,GO:0045229,GO:0071840,GO:0071944 Bacteria 234V1@1762,2H94S@201174,COG1305@1,COG1305@2,COG4196@1,COG4196@2 NA|NA|NA E transglutaminase OLIIENHM_00510 216594.MMAR_4816 7.2e-23 113.2 Mycobacteriaceae Bacteria 23BGE@1762,28SY0@1,2GV00@201174,2ZF7G@2 NA|NA|NA OLIIENHM_00511 1172186.KB911472_gene5309 1.8e-225 788.5 Mycobacteriaceae ansP ko:K03293,ko:K11738 ko00000,ko02000 2.A.3.1,2.A.3.1.8 Bacteria 234JB@1762,2GJ0X@201174,COG1113@1,COG1113@2 NA|NA|NA E permease OLIIENHM_00512 931627.MycrhDRAFT_5830 4.7e-115 421.0 Mycobacteriaceae 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 Bacteria 234GR@1762,2GNWB@201174,COG0412@1,COG0412@2 NA|NA|NA Q dienelactone hydrolase OLIIENHM_00513 557599.MKAN_28795 7.8e-49 200.7 Mycobacteriaceae Bacteria 23F8X@1762,28MQW@1,2I50D@201174,32WFA@2 NA|NA|NA OLIIENHM_00514 547163.BN979_04326 0.0 1422.5 Mycobacteriaceae 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 Bacteria 237JD@1762,2GJ8H@201174,COG3119@1,COG3119@2 NA|NA|NA P Sulfatase OLIIENHM_00515 931627.MycrhDRAFT_6074 9.9e-158 563.1 Mycobacteriaceae Bacteria 23CKA@1762,2GKPS@201174,COG4850@1,COG4850@2 NA|NA|NA S Uncharacterized conserved protein (DUF2183) OLIIENHM_00516 931627.MycrhDRAFT_6073 7.7e-106 390.6 Mycobacteriaceae Bacteria 237U9@1762,2B0NY@1,2ICKX@201174,31T0Q@2 NA|NA|NA OLIIENHM_00517 1440774.Y900_001435 2.1e-130 471.9 Mycobacteriaceae trpH GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004534,GO:0004536,GO:0004540,GO:0005488,GO:0006139,GO:0006259,GO:0006521,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008409,GO:0009987,GO:0010565,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016796,GO:0016895,GO:0016896,GO:0019222,GO:0030145,GO:0031323,GO:0033238,GO:0034641,GO:0035312,GO:0042578,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0090357,GO:0090501,GO:0090503,GO:0097657,GO:0140097,GO:0140098,GO:1901360 3.1.3.97 ko:K07053 R00188,R11188 RC00078 ko00000,ko01000 Bacteria 236JW@1762,2GIZ5@201174,COG0613@1,COG0613@2 NA|NA|NA S Protein of unknown function (DUF3097) OLIIENHM_00518 1121374.KB891576_gene539 7.3e-18 98.6 Gammaproteobacteria Bacteria 1NA6X@1224,1SIJT@1236,COG0477@1,COG2814@2 NA|NA|NA EGP Major Facilitator Superfamily OLIIENHM_00520 585531.HMPREF0063_10136 6.6e-165 587.0 Propionibacteriales 2.3.1.16,2.3.1.9 ko:K00626,ko:K00632 ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00087,M00088,M00095,M00113,M00373,M00374,M00375 R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GJAC@201174,4DNMI@85009,COG0183@1,COG0183@2 NA|NA|NA I Belongs to the thiolase family OLIIENHM_00521 101510.RHA1_ro02468 3.3e-104 385.2 Nocardiaceae Bacteria 2GISM@201174,4FYBJ@85025,COG2133@1,COG2133@2 NA|NA|NA G Glucose / Sorbosone dehydrogenase OLIIENHM_00522 317025.Tcr_0338 7.5e-124 450.7 Thiotrichales Bacteria 1P3SQ@1224,1RRMI@1236,462ZC@72273,COG1680@1,COG1680@2 NA|NA|NA V Beta-lactamase OLIIENHM_00523 931627.MycrhDRAFT_1721 3.2e-17 94.7 Actinobacteria Bacteria 2AXYQ@1,2IJFV@201174,31JIC@2 NA|NA|NA OLIIENHM_00524 232348.ADXL01000066_gene2669 1.1e-170 606.7 Cyanobacteria Bacteria 1G40U@1117,COG1574@1,COG1574@2 NA|NA|NA S Amidohydrolase family OLIIENHM_00527 1298608.JCM18900_11591 1.4e-06 60.1 Moraxellaceae Bacteria 1P7YZ@1224,1SUFY@1236,2AAAZ@1,30ZKM@2,3NQH5@468 NA|NA|NA OLIIENHM_00528 1313172.YM304_13900 1.1e-111 409.8 Actinobacteria Bacteria 2GMRE@201174,COG2141@1,COG2141@2 NA|NA|NA C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases OLIIENHM_00529 1123508.JH636452_gene6902 3.7e-34 150.6 Planctomycetes Bacteria 2J097@203682,COG2343@1,COG2343@2 NA|NA|NA S Domain of unknown function (DUF427) OLIIENHM_00530 443218.AS9A_4470 2.2e-291 1008.1 Actinobacteria hcr GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050662,GO:0051536,GO:0051537,GO:0051540,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.14.19.3 ko:K00508,ko:K11933 ko00591,ko01100,map00591,map01100 R07063 RC00917 ko00000,ko00001,ko01000,ko01004 Bacteria 2I2SJ@201174,COG1018@1,COG1018@2,COG3239@1,COG3239@2 NA|NA|NA C Fatty acid desaturase OLIIENHM_00531 443218.AS9A_4469 9.1e-112 410.2 Mycobacteriaceae GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006089,GO:0006355,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009438,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019172,GO:0019219,GO:0019222,GO:0019243,GO:0019249,GO:0019752,GO:0031323,GO:0031326,GO:0032787,GO:0040007,GO:0042180,GO:0042182,GO:0043436,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044403,GO:0044419,GO:0046185,GO:0046394,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0051596,GO:0051704,GO:0060255,GO:0061727,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901575,GO:1901576,GO:1901615,GO:1901617,GO:1903506,GO:2000112,GO:2001141 Bacteria 23F3Y@1762,2IAKG@201174,COG2207@1,COG2207@2 NA|NA|NA K Arabinose-binding domain of AraC transcription regulator, N-term OLIIENHM_00532 1280954.HPO_10155 7.5e-112 410.6 Hyphomonadaceae Bacteria 1MVIX@1224,2TUXG@28211,43Z17@69657,COG1902@1,COG1902@2 NA|NA|NA C NADH flavin oxidoreductase NADH oxidase family protein OLIIENHM_00533 258533.BN977_03885 0.0 1095.5 Mycobacteriaceae parE 5.99.1.3 ko:K02470,ko:K02622 ko00000,ko01000,ko02048,ko03032,ko03036,ko03400 Bacteria 237G1@1762,2HNHN@201174,COG0187@1,COG0187@2 NA|NA|NA L DNA Topoisomerase OLIIENHM_00534 1440774.Y900_008910 6.9e-111 406.8 Mycobacteriaceae citA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 23359@1762,2GKST@201174,COG0372@1,COG0372@2 NA|NA|NA C Belongs to the citrate synthase family OLIIENHM_00535 931627.MycrhDRAFT_0522 1.5e-212 745.7 Mycobacteriaceae fprB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0044424,GO:0044464,GO:0055114,GO:0071944 1.18.1.2,1.19.1.1 ko:K00528 R10159 ko00000,ko01000 Bacteria 2355D@1762,2GJ4A@201174,COG0493@1,COG0493@2 NA|NA|NA C ferredoxin OLIIENHM_00536 1078020.KEK_11663 6.3e-169 600.1 Mycobacteriaceae Bacteria 23319@1762,2GMBI@201174,COG3396@1,COG3396@2 NA|NA|NA S P-aminobenzoate N-oxygenase AurF OLIIENHM_00537 1440774.Y900_008940 9.6e-187 659.4 Mycobacteriaceae serC GO:0001505,GO:0003674,GO:0003824,GO:0004760,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005886,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006807,GO:0008150,GO:0008152,GO:0008453,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019265,GO:0019752,GO:0040007,GO:0042133,GO:0042136,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0065007,GO:0065008,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 232BR@1762,2GKYK@201174,COG1932@1,COG1932@2 NA|NA|NA E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine OLIIENHM_00538 1440774.Y900_008945 3.4e-90 338.2 Mycobacteriaceae GO:0008150,GO:0040007 Bacteria 235CY@1762,28PUQ@1,2GNQM@201174,2ZCFK@2 NA|NA|NA S Protein of unknown function (DUF3071) OLIIENHM_00539 1380386.JIAW01000003_gene558 2.5e-29 134.8 Mycobacteriaceae Bacteria 23ANG@1762,2EVP5@1,2IQ93@201174,33P34@2 NA|NA|NA S Protein of unknown function (DUF2537) OLIIENHM_00540 931627.MycrhDRAFT_0517 7.4e-120 436.8 Mycobacteriaceae spoU2 2.1.1.185 ko:K03218,ko:K03437 ko00000,ko01000,ko03009,ko03016 Bacteria 233P1@1762,2GJ12@201174,COG0566@1,COG0566@2 NA|NA|NA J rRNA methyltransferase OLIIENHM_00541 931627.MycrhDRAFT_0515 2.2e-23 114.8 Mycobacteriaceae Bacteria 23AVF@1762,2CGTN@1,2ISJQ@201174,33IM2@2 NA|NA|NA S Protein of unknown function (DUF2530) OLIIENHM_00542 1150599.MPHLEI_21484 3.4e-58 231.1 Mycobacteriaceae Bacteria 238K2@1762,2INRZ@201174,COG3832@1,COG3832@2 NA|NA|NA S Activator of Hsp90 ATPase 1 family protein OLIIENHM_00543 931627.MycrhDRAFT_0513 5e-115 421.0 Mycobacteriaceae Bacteria 233ZT@1762,28NWB@1,2GJ74@201174,2ZBU7@2 NA|NA|NA S Protein of unknown function (DUF3027) OLIIENHM_00544 1440774.Y900_008980 2e-219 768.5 Mycobacteriaceae GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 232X4@1762,2GKRT@201174,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily OLIIENHM_00545 1440774.Y900_008985 1.9e-54 218.8 Mycobacteriaceae GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 Bacteria 238PE@1762,2EMAJ@1,2IJ38@201174,33EZJ@2 NA|NA|NA S Protein of unknown function (DUF2771) OLIIENHM_00546 710421.Mycch_4418 1.4e-63 248.8 Mycobacteriaceae cspB ko:K03704 ko00000,ko03000 Bacteria 238MD@1762,2IKXN@201174,COG1278@1,COG1278@2 NA|NA|NA K Cold-shock' OLIIENHM_00547 1150599.MPHLEI_21514 7.1e-55 219.9 Mycobacteriaceae yccF Bacteria 2398D@1762,2IKS5@201174,COG3304@1,COG3304@2 NA|NA|NA S membrane OLIIENHM_00548 931627.MycrhDRAFT_0507 5e-153 547.4 Mycobacteriaceae moaA GO:0003674,GO:0003824,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.22,4.6.1.17 ko:K03639,ko:K20967 ko00790,ko01100,ko04122,map00790,map01100,map04122 R09394,R11372 RC03420,RC03425 ko00000,ko00001,ko01000 Bacteria 232UP@1762,2GN0V@201174,COG2896@1,COG2896@2 NA|NA|NA H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate OLIIENHM_00549 931627.MycrhDRAFT_0506 1.2e-21 109.0 Mycobacteriaceae moaD 2.8.1.12 ko:K03636,ko:K21142 ko00790,ko01100,ko04122,map00790,map01100,map04122 R09395 RC02507 ko00000,ko00001,ko01000 Bacteria 23B79@1762,2IQIT@201174,COG1977@1,COG1977@2 NA|NA|NA H Molybdopterin converting factor, small subunit OLIIENHM_00550 700508.D174_23225 1.9e-62 246.5 Mycobacteriaceae ygaU GO:0003674,GO:0005488,GO:0005575,GO:0005576,GO:0008150,GO:0009892,GO:0010035,GO:0010038,GO:0010468,GO:0010605,GO:0010629,GO:0019222,GO:0030955,GO:0031420,GO:0035864,GO:0040008,GO:0040009,GO:0040010,GO:0042221,GO:0043167,GO:0043169,GO:0045927,GO:0046872,GO:0048518,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007 ko:K21687 ko00000 GH23 Bacteria 232DU@1762,2GK68@201174,COG1652@1,COG1652@2 NA|NA|NA S Transglycosylase-like domain OLIIENHM_00551 1440774.Y900_009025 1.1e-55 222.6 Mycobacteriaceae moaE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.7.7.80,2.8.1.11,2.8.1.12 ko:K03635,ko:K21147 ko00790,ko01100,ko04122,map00790,map01100,map04122 R07459,R07461,R09395 RC00043,RC02507 ko00000,ko00001,ko01000 Bacteria 2396E@1762,2IQ9F@201174,COG0314@1,COG0314@2 NA|NA|NA H Molybdopterin converting factor, large subunit OLIIENHM_00552 1440774.Y900_009030 2.4e-62 245.0 Mycobacteriaceae mog 2.8.1.12,4.6.1.17 ko:K03635,ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 R09395,R11372 RC02507,RC03425 ko00000,ko00001,ko01000 Bacteria 239CN@1762,2II28@201174,COG0521@1,COG0521@2 NA|NA|NA H Molybdenum cofactor synthesis OLIIENHM_00553 710686.Mycsm_05472 1.2e-52 212.6 Mycobacteriaceae moaC 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 R11372 RC03425 ko00000,ko00001,ko01000 Bacteria 238JH@1762,2IHR6@201174,COG0315@1,COG0315@2 NA|NA|NA H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) OLIIENHM_00554 1440774.Y900_009040 1.6e-17 94.7 Mycobacteriaceae Bacteria 23B7F@1762,2C7NN@1,2GR44@201174,33FDU@2 NA|NA|NA OLIIENHM_00555 1440774.Y900_009045 2.3e-301 1041.2 Mycobacteriaceae M1-1077 Bacteria 235V8@1762,2GURQ@201174,COG2378@1,COG2378@2 NA|NA|NA K Helicase conserved C-terminal domain OLIIENHM_00556 931627.MycrhDRAFT_0499 7e-303 1045.8 Mycobacteriaceae ercc3 3.6.4.12 ko:K10843 ko03022,ko03420,map03022,map03420 M00290 ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 Bacteria 2343U@1762,2GIR9@201174,COG1061@1,COG1061@2 NA|NA|NA L Type III restriction enzyme res subunit OLIIENHM_00557 1341646.CBMO010000020_gene6142 1.4e-103 382.9 Mycobacteriaceae Bacteria 2365F@1762,2GK13@201174,COG0583@1,COG0583@2 NA|NA|NA K Bacterial regulatory helix-turn-helix protein, lysR family OLIIENHM_00558 710687.KI912270_gene887 8.2e-33 146.4 Mycobacteriaceae gnd GO:0003674,GO:0003824,GO:0004616,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006081,GO:0006082,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019362,GO:0019520,GO:0019521,GO:0019637,GO:0019682,GO:0019693,GO:0019752,GO:0032787,GO:0034641,GO:0042802,GO:0042803,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046176,GO:0046177,GO:0046395,GO:0046483,GO:0046496,GO:0046983,GO:0051156,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072329,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 1.1.1.343,1.1.1.44 ko:K00033 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200 M00004,M00006 R01528,R10221 RC00001,RC00539 ko00000,ko00001,ko00002,ko01000 iECS88_1305.ECS88_2128,iECW_1372.ECW_m2189,iEKO11_1354.EKO11_1765,iPC815.YPO1541,iWFL_1372.ECW_m2189 Bacteria 234KD@1762,2GJ2J@201174,COG0362@1,COG0362@2 NA|NA|NA G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH OLIIENHM_00559 446468.Ndas_4956 7.4e-78 298.1 Streptosporangiales slpD Bacteria 2GJYS@201174,4EFG6@85012,COG0596@1,COG0596@2 NA|NA|NA S TAP-like protein OLIIENHM_00560 931627.MycrhDRAFT_6770 2.4e-235 821.2 Mycobacteriaceae guaC GO:0003674,GO:0003824,GO:0003920,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0015949,GO:0015950,GO:0015951,GO:0016020,GO:0016491,GO:0016651,GO:0016657,GO:0019637,GO:0019693,GO:0034641,GO:0042802,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.1.1.205,1.7.1.7 ko:K00088,ko:K00364 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R01134,R08240 RC00143,RC00457,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 iEC042_1314.EC042_0103,iECIAI39_1322.ECIAI39_0105,iECUMN_1333.ECUMN_0102 Bacteria 234UT@1762,2GNDC@201174,COG0516@1,COG0516@2,COG0517@1,COG0517@2 NA|NA|NA F IMP dehydrogenase GMP reductase OLIIENHM_00561 1380386.JIAW01000005_gene1666 6e-175 620.5 Mycobacteriaceae tlyC ko:K03699 ko00000,ko02042 Bacteria 232YI@1762,2GKN5@201174,COG1253@1,COG1253@2 NA|NA|NA S Hemolysins and related proteins containing CBS domains OLIIENHM_00562 1380386.JIAW01000005_gene1667 4.5e-138 497.7 Mycobacteriaceae ytfL ko:K03699 ko00000,ko02042 Bacteria 2342G@1762,2GJ8X@201174,COG1253@1,COG1253@2 NA|NA|NA S COG1253 Hemolysins and related proteins containing CBS domains OLIIENHM_00563 931627.MycrhDRAFT_6773 2.9e-109 401.7 Mycobacteriaceae Bacteria 23381@1762,2BYH3@1,2GMTF@201174,2Z7SZ@2 NA|NA|NA S 3-methyladenine DNA glycosylase OLIIENHM_00564 1440774.Y900_025135 0.0 1207.6 Mycobacteriaceae glcB GO:0000287,GO:0001968,GO:0003674,GO:0003824,GO:0004474,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006081,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009060,GO:0009117,GO:0009150,GO:0009259,GO:0009436,GO:0009986,GO:0009987,GO:0015936,GO:0015980,GO:0016020,GO:0016054,GO:0016740,GO:0016746,GO:0016999,GO:0017144,GO:0019637,GO:0019693,GO:0019752,GO:0022610,GO:0030112,GO:0030312,GO:0030313,GO:0031975,GO:0032787,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0042603,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043236,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044403,GO:0044406,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046185,GO:0046395,GO:0046483,GO:0046487,GO:0046810,GO:0046872,GO:0046912,GO:0046983,GO:0048037,GO:0050662,GO:0050840,GO:0051186,GO:0051704,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:0072350,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901575 2.3.3.9 ko:K01638 ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200 M00012 R00472 RC00004,RC00308,RC02747 ko00000,ko00001,ko00002,ko01000 iJN746.PP_0356 Bacteria 234CM@1762,2HNC6@201174,COG2225@1,COG2225@2 NA|NA|NA C Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA OLIIENHM_00565 1440774.Y900_025130 3.6e-191 674.9 Mycobacteriaceae GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K07114 ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 Bacteria 232G3@1762,2GUB3@201174,COG2304@1,COG2304@2 NA|NA|NA S von willebrand factor type a OLIIENHM_00566 1440774.Y900_025125 2.7e-117 428.3 Mycobacteriaceae Bacteria 235W8@1762,2I8WB@201174,COG0596@1,COG0596@2 NA|NA|NA S Alpha beta hydrolase OLIIENHM_00567 875328.JDM601_1926 1.3e-168 599.0 Mycobacteriaceae gcvP GO:0003674,GO:0003824,GO:0004375,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016638,GO:0016642,GO:0030312,GO:0040007,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944 1.4.4.2 ko:K00281,ko:K00282 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 iECIAI39_1322.ECIAI39_3318 Bacteria 233DG@1762,2GJ11@201174,COG0403@1,COG0403@2,COG1003@1,COG1003@2 NA|NA|NA E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor OLIIENHM_00572 525368.HMPREF0591_5483 2.7e-302 1043.9 Mycobacteriaceae yjjK GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 Bacteria 234XU@1762,2GKBQ@201174,COG0488@1,COG0488@2 NA|NA|NA S ABC transporter OLIIENHM_00573 1440774.Y900_021645 2.5e-48 198.4 Mycobacteriaceae ssb1 ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 ko00000,ko00001,ko03029,ko03032,ko03400 Bacteria 2398G@1762,2GQIQ@201174,COG0629@1,COG0629@2 NA|NA|NA L Single-stranded DNA-binding protein OLIIENHM_00574 1440774.Y900_021630 2.4e-286 991.1 Mycobacteriaceae copD ko:K02351,ko:K07245 ko00000,ko02000 9.B.62.1 Bacteria 233IV@1762,2GKIR@201174,COG3336@1,COG3336@2 NA|NA|NA P CytoChrome c oxidase Caa3 assembly factor OLIIENHM_00575 931627.MycrhDRAFT_3885 4.6e-41 174.9 Mycobacteriaceae Bacteria 233C7@1762,2E9A0@1,2HSBR@201174,333I1@2 NA|NA|NA S Domain of unknown function (DUF4333) OLIIENHM_00576 1440774.Y900_021625 0.0 1261.1 Mycobacteriaceae plsB GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.3.1.15 ko:K00631 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 232HX@1762,2GMQF@201174,COG2937@1,COG2937@2 NA|NA|NA I Belongs to the GPAT DAPAT family OLIIENHM_00577 931627.MycrhDRAFT_4439 4.7e-230 803.9 Mycobacteriaceae plsC GO:0003674,GO:0003824,GO:0003841,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0042171,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071617,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.3.1.51,3.1.3.3 ko:K00655,ko:K07003,ko:K15781 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 233PB@1762,2GJVX@201174,COG0204@1,COG0204@2,COG0560@1,COG0560@2 NA|NA|NA EI HAD-superfamily subfamily IB hydrolase, TIGR01490 OLIIENHM_00578 1440774.Y900_021615 7.5e-219 766.5 Mycobacteriaceae GO:0000302,GO:0001666,GO:0003674,GO:0003824,GO:0004144,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0006638,GO:0006639,GO:0006641,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019432,GO:0030312,GO:0036293,GO:0040007,GO:0042221,GO:0042493,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0044464,GO:0045017,GO:0046460,GO:0046463,GO:0046486,GO:0047196,GO:0050896,GO:0051704,GO:0070482,GO:0071704,GO:0071731,GO:0071944,GO:0097366,GO:1901576,GO:1901698,GO:1901700 2.3.1.20 ko:K00635 ko00561,ko01100,map00561,map01100 M00089 R02251 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 Bacteria 234ZI@1762,2GKU0@201174,COG1020@1,COG1020@2 NA|NA|NA I Belongs to the long-chain O-acyltransferase family OLIIENHM_00579 931627.MycrhDRAFT_4447 5.7e-169 600.5 Mycobacteriaceae lipQ Bacteria 235B4@1762,2GTEV@201174,COG0657@1,COG0657@2 NA|NA|NA I Prolyl oligopeptidase family OLIIENHM_00582 1133849.O3I_029870 5.5e-228 797.3 Nocardiaceae Bacteria 2GKI5@201174,4FWUN@85025,COG1835@1,COG1835@2 NA|NA|NA I Acyltransferase family OLIIENHM_00583 1440774.Y900_021350 5e-107 394.0 Mycobacteriaceae echA14 GO:0003674,GO:0003824,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 Bacteria 233FJ@1762,2H2G7@201174,COG1024@1,COG1024@2 NA|NA|NA I Belongs to the enoyl-CoA hydratase isomerase family OLIIENHM_00584 931627.MycrhDRAFT_4460 1.2e-164 586.3 Mycobacteriaceae Bacteria 232HK@1762,2I9AH@201174,COG1403@1,COG1403@2 NA|NA|NA V endonuclease OLIIENHM_00585 350058.Mvan_1940 1.4e-156 560.1 Mycobacteriaceae Bacteria 234AQ@1762,2IAH7@201174,COG5361@1,COG5361@2 NA|NA|NA S Conserved Protein OLIIENHM_00586 1440774.Y900_021315 1.4e-193 682.2 Mycobacteriaceae yngJ GO:0000062,GO:0000166,GO:0003674,GO:0003824,GO:0003995,GO:0004085,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005759,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009605,GO:0009719,GO:0009725,GO:0009987,GO:0009991,GO:0010033,GO:0014070,GO:0016020,GO:0016042,GO:0016043,GO:0016054,GO:0016491,GO:0016627,GO:0017076,GO:0019395,GO:0019605,GO:0019626,GO:0019752,GO:0022607,GO:0030258,GO:0030554,GO:0031090,GO:0031667,GO:0031960,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033218,GO:0033539,GO:0033993,GO:0034440,GO:0036094,GO:0042221,GO:0042594,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046359,GO:0046395,GO:0046459,GO:0048037,GO:0048545,GO:0050660,GO:0050662,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051384,GO:0052890,GO:0055114,GO:0065003,GO:0070013,GO:0071704,GO:0071840,GO:0072329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901567,GO:1901575,GO:1901681 1.3.8.1,1.3.99.12 ko:K00248,ko:K11410,ko:K18244 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 Bacteria 235E8@1762,2GMEM@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_00587 1440774.Y900_021310 1.2e-277 962.2 Mycobacteriaceae accA1 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 6.3.4.14,6.4.1.2,6.4.1.3,6.4.1.4 ko:K01968,ko:K11263 ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212 M00036,M00082,M00741 R00742,R01859,R04138,R04385 RC00040,RC00097,RC00253,RC00367,RC00609,RC00942 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv2501c Bacteria 234ZH@1762,2GIZP@201174,COG4770@1,COG4770@2 NA|NA|NA I carboxylase OLIIENHM_00588 931627.MycrhDRAFT_4470 2e-182 645.2 Mycobacteriaceae mccB 2.1.3.15,6.4.1.3,6.4.1.4 ko:K01969,ko:K15052 ko00280,ko00720,ko01100,ko01200,map00280,map00720,map01100,map01200 M00036,M00376 R01859,R04138 RC00097,RC00367,RC00609,RC00942 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_3290 Bacteria 233KH@1762,2GIRU@201174,COG4799@1,COG4799@2 NA|NA|NA I Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) OLIIENHM_00589 1408452.JAGZ01000002_gene4741 3.6e-24 117.1 Mycobacteriaceae xseB GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494 3.1.11.6 ko:K03602 ko03430,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 23B6F@1762,2GR0U@201174,COG1722@1,COG1722@2 NA|NA|NA L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides OLIIENHM_00590 1440774.Y900_018930 1.3e-168 599.4 Mycobacteriaceae xseA GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 3.1.11.6 ko:K03601 ko03430,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 23458@1762,2GJAS@201174,COG1570@1,COG1570@2 NA|NA|NA L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides OLIIENHM_00591 1440774.Y900_018935 7.1e-64 250.4 Mycobacteriaceae GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 Bacteria 235IG@1762,2EATU@1,2IKQC@201174,334VK@2 NA|NA|NA OLIIENHM_00592 547163.BN979_05245 4.9e-158 563.9 Mycobacteriaceae ispH 1.17.7.4,2.7.4.25 ko:K00945,ko:K02945,ko:K03527 ko00240,ko00900,ko01100,ko01110,ko01130,ko03010,map00240,map00900,map01100,map01110,map01130,map03010 M00052,M00096,M00178 R00158,R00512,R01665,R05884,R08210 RC00002,RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko03011 iIT341.HP0400,iLJ478.TM1444 Bacteria 233KG@1762,2GIZ7@201174,COG0761@1,COG0761@2 NA|NA|NA IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis OLIIENHM_00593 246196.MSMEI_5086 8.3e-53 214.5 Mycobacteriaceae Bacteria 232E6@1762,2FH0D@1,2I8QN@201174,348VF@2 NA|NA|NA OLIIENHM_00594 931627.MycrhDRAFT_5425 8.3e-175 619.8 Mycobacteriaceae ychF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 ko:K06942 ko00000,ko03009 Bacteria 23386@1762,2GIXI@201174,COG0012@1,COG0012@2 NA|NA|NA J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner OLIIENHM_00595 211165.AJLN01000145_gene1237 4.3e-59 234.2 Stigonemataceae dps ko:K04047 ko00000,ko03036 Bacteria 1G586@1117,1JI8D@1189,COG0783@1,COG0783@2 NA|NA|NA P Ferritin-like domain OLIIENHM_00596 710686.Mycsm_06442 1e-51 209.5 Mycobacteriaceae GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.8.1.8 ko:K03671,ko:K03672 ko04621,ko05418,map04621,map05418 ko00000,ko00001,ko01000,ko03110 Bacteria 239GK@1762,2IHQV@201174,COG3118@1,COG3118@2 NA|NA|NA O TIGRFAM Thioredoxin OLIIENHM_00597 1379270.AUXF01000001_gene2522 7.6e-142 511.5 Bacteria cphA 6.3.2.13,6.3.2.29,6.3.2.30 ko:K01928,ko:K03802 ko00300,ko00550,map00300,map00550 R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 Bacteria COG0189@1,COG0189@2,COG0769@1,COG0769@2 NA|NA|NA M UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity OLIIENHM_00598 931627.MycrhDRAFT_5403 6.6e-116 423.7 Mycobacteriaceae bpoB Bacteria 2339R@1762,2I4EY@201174,COG0596@1,COG0596@2 NA|NA|NA S Alpha beta hydrolase OLIIENHM_00599 318424.EU78_20745 7.2e-36 157.1 Mycobacteriaceae ko:K18481 M00670 ko00000,ko00002,ko02000 3.A.1.27.4,3.A.1.27.5 Bacteria 236KI@1762,2E5BU@1,2IFCH@201174,3303V@2 NA|NA|NA OLIIENHM_00600 1440774.Y900_019050 9e-33 146.7 Mycobacteriaceae GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 ko:K18481 M00670 ko00000,ko00002,ko02000 3.A.1.27.4,3.A.1.27.5 Bacteria 238VW@1762,2IG0F@201174,COG0443@1,COG0443@2 NA|NA|NA O Heat shock 70 kDa protein OLIIENHM_00601 931627.MycrhDRAFT_5399 1.6e-136 492.3 Mycobacteriaceae ephC Bacteria 232WQ@1762,2HMX1@201174,COG0596@1,COG0596@2 NA|NA|NA S Alpha beta hydrolase OLIIENHM_00602 164757.Mjls_4315 9.9e-90 336.7 Mycobacteriaceae ko:K07124 ko00000 Bacteria 23F9W@1762,2I9IM@201174,COG0300@1,COG0300@2 NA|NA|NA I Belongs to the short-chain dehydrogenases reductases (SDR) family OLIIENHM_00603 931627.MycrhDRAFT_5397 4.3e-119 434.9 Mycobacteriaceae Bacteria 232NC@1762,2GMM6@201174,COG1020@1,COG1020@2 NA|NA|NA Q D-alanine [D-alanyl carrier protein] ligase activity OLIIENHM_00605 931627.MycrhDRAFT_5394 6.1e-273 946.4 Mycobacteriaceae Bacteria 232MH@1762,2CB1C@1,2GM87@201174,2Z7M2@2 NA|NA|NA S Transmembrane protein of unknown function (DUF3556) OLIIENHM_00606 931627.MycrhDRAFT_5393 3.5e-192 677.6 Mycobacteriaceae fadA6_3 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0003988,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005777,GO:0005782,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0031907,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0032787,GO:0034440,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0055114,GO:0070013,GO:0071704,GO:0072329,GO:0097159,GO:1901363,GO:1901575 2.3.1.16,2.3.1.9 ko:K00626,ko:K00632 ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00087,M00088,M00095,M00113,M00373,M00374,M00375 R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2339D@1762,2GJAC@201174,COG0183@1,COG0183@2 NA|NA|NA I Belongs to the thiolase family OLIIENHM_00607 314265.R2601_02548 1.6e-10 73.6 Alphaproteobacteria Bacteria 1NQIG@1224,2EZS5@1,2UNXU@28211,33SWY@2 NA|NA|NA OLIIENHM_00609 1209984.BN978_01318 1.2e-81 309.3 Mycobacteriaceae Bacteria 237WN@1762,2GKXH@201174,COG2842@1,COG2842@2 NA|NA|NA S Bacterial TniB protein OLIIENHM_00610 1209984.BN978_01318 2.6e-74 285.0 Mycobacteriaceae Bacteria 237WN@1762,2GKXH@201174,COG2842@1,COG2842@2 NA|NA|NA S Bacterial TniB protein OLIIENHM_00611 1209984.BN978_01317 0.0 1147.9 Mycobacteriaceae ko:K07497 ko00000 Bacteria 233XH@1762,2HITH@201174,COG2801@1,COG2801@2,COG3415@1,COG3415@2 NA|NA|NA L Integrase core domain OLIIENHM_00612 1209984.BN978_01316 2.3e-88 332.0 Mycobacteriaceae Bacteria 239NE@1762,2DPKK@1,2IH34@201174,332IR@2 NA|NA|NA S TnsA endonuclease N terminal protein OLIIENHM_00613 1299327.I546_6515 4.9e-283 979.9 Mycobacteriaceae ctaD GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0034220,GO:0040007,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 Bacteria 233K8@1762,2GJHX@201174,COG0843@1,COG0843@2 NA|NA|NA C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B OLIIENHM_00614 710685.MycrhN_0177 1.7e-57 228.8 Mycobacteriaceae osmC ko:K04063 ko00000 Bacteria 239N1@1762,2IFFB@201174,COG1764@1,COG1764@2 NA|NA|NA O OsmC-like protein OLIIENHM_00615 557599.MKAN_17330 2.3e-49 201.8 Mycobacteriaceae Bacteria 239KN@1762,2IIJ3@201174,COG5592@1,COG5592@2 NA|NA|NA S Hemerythrin HHE cation binding OLIIENHM_00616 487521.OCU_19680 5.4e-36 156.8 Mycobacteriaceae Bacteria 238P3@1762,2GS7C@201174,COG4309@1,COG4309@2 NA|NA|NA S Uncharacterized conserved protein (DUF2249) OLIIENHM_00617 1440774.Y900_014855 2.1e-72 278.9 Mycobacteriaceae aftD GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 ko:K16648 ko00000,ko01000,ko01003 Bacteria 23374@1762,2GMA5@201174,COG4981@1,COG4981@2 NA|NA|NA I capsule organization OLIIENHM_00618 1440774.Y900_014850 5.5e-154 550.4 Mycobacteriaceae php ko:K07048 ko00000 Bacteria 2360H@1762,2GMZ6@201174,COG1735@1,COG1735@2 NA|NA|NA S Phosphotriesterase OLIIENHM_00619 1440774.Y900_014845 9.6e-219 766.1 Mycobacteriaceae MA20_40105 6.2.1.7 ko:K15868 ko00121,map00121 ko00000,ko00001,ko01000 Bacteria 23426@1762,2GJAA@201174,COG0318@1,COG0318@2 NA|NA|NA IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II OLIIENHM_00620 931627.MycrhDRAFT_2614 2.2e-184 651.7 Mycobacteriaceae Bacteria 2337I@1762,2GP6W@201174,COG1835@1,COG1835@2 NA|NA|NA I Acyltransferase OLIIENHM_00621 931627.MycrhDRAFT_2613 1.1e-172 612.8 Mycobacteriaceae porA Bacteria 23299@1762,2B1K4@1,2I8GP@201174,31U1J@2 NA|NA|NA S Protein of unknown function (DUF3068) OLIIENHM_00622 931627.MycrhDRAFT_2612 8.1e-185 653.7 Mycobacteriaceae Bacteria 233XX@1762,28HIC@1,2GNK5@201174,2Z7TU@2 NA|NA|NA OLIIENHM_00623 931627.MycrhDRAFT_2611 3.7e-181 641.0 Mycobacteriaceae Bacteria 2340E@1762,2GK8D@201174,COG0438@1,COG0438@2 NA|NA|NA M glycosyl transferase OLIIENHM_00625 1440774.Y900_006320 1.3e-85 322.8 Mycobacteriaceae hpf GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113 ko:K05808 ko00000,ko03009 Bacteria 233GS@1762,2GMYF@201174,COG1544@1,COG1544@2 NA|NA|NA J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase OLIIENHM_00626 557599.MKAN_21310 1.2e-77 296.2 Mycobacteriaceae ctsW ko:K02242 M00429 ko00000,ko00002,ko02044 Bacteria 23771@1762,2I9PA@201174,COG1040@1,COG1040@2 NA|NA|NA S phosphoribosyltransferase OLIIENHM_00627 1408452.JAGZ01000002_gene4222 3.5e-86 325.5 Mycobacteriaceae 2.7.13.3 ko:K02480 ko00000,ko01000,ko01001,ko02022 Bacteria 2348E@1762,2IAG1@201174,COG4585@1,COG4585@2 NA|NA|NA T Histidine kinase OLIIENHM_00628 557599.MKAN_02415 1.3e-71 276.2 Mycobacteriaceae ko:K07684 ko02020,map02020 M00471 ko00000,ko00001,ko00002,ko02022 Bacteria 23963@1762,2IHKN@201174,COG2197@1,COG2197@2 NA|NA|NA K helix_turn_helix, Lux Regulon OLIIENHM_00629 710687.KI912270_gene6250 1e-157 563.5 Mycobacteriaceae ampC2 Bacteria 236ZJ@1762,2GNNF@201174,COG1680@1,COG1680@2 NA|NA|NA V Beta-lactamase OLIIENHM_00630 1440774.Y900_006390 3.3e-258 897.5 Mycobacteriaceae lpqB GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 Bacteria 232ZF@1762,2GJ5Y@201174,COG5401@1,COG5401@2 NA|NA|NA S Lipoprotein lpqB OLIIENHM_00631 1440774.Y900_006395 4.3e-268 930.2 Mycobacteriaceae mtrB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 2.7.13.3 ko:K02484,ko:K07653,ko:K07654 ko02020,map02020 M00460,M00461 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 233YC@1762,2GJ2D@201174,COG5002@1,COG5002@2 NA|NA|NA T Histidine kinase OLIIENHM_00632 246196.MSMEI_1835 4.5e-91 340.5 Mycobacteriaceae Bacteria 232GP@1762,2GJE6@201174,COG0745@1,COG0745@2 NA|NA|NA K response regulator OLIIENHM_00633 931627.MycrhDRAFT_2278 1.9e-100 372.1 Mycobacteriaceae trxB GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.9,4.3.1.9 ko:K00384,ko:K03671,ko:K22345 ko00030,ko00450,ko04621,ko05418,map00030,map00450,map04621,map05418 R01544,R02016,R03596,R09372 RC00013,RC00544,RC02518,RC02873 ko00000,ko00001,ko01000,ko03110 iNJ661.Rv3913,iPC815.YPO1374 Bacteria 234E1@1762,2GKD2@201174,COG0492@1,COG0492@2 NA|NA|NA C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family OLIIENHM_00634 164757.Mjls_5779 3.2e-42 177.6 Mycobacteriaceae trxA GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009055,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0015037,GO:0015038,GO:0016020,GO:0016209,GO:0016491,GO:0016651,GO:0016657,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0022900,GO:0030312,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071944,GO:0080007,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.8.1.8,1.8.1.9 ko:K00384,ko:K03671,ko:K03672 ko00450,ko04621,ko05418,map00450,map04621,map05418 R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000,ko03110 Bacteria 239Y7@1762,2IQ9T@201174,COG3118@1,COG3118@2 NA|NA|NA O belongs to the thioredoxin family OLIIENHM_00635 1440774.Y900_013300 1.8e-194 685.3 Mycobacteriaceae cwlM GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 3.2.1.17,3.5.1.28 ko:K01185,ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 Bacteria 236G9@1762,2GPA9@201174,COG0860@1,COG0860@2,COG3409@1,COG3409@2 NA|NA|NA M N-acetylmuramoyl-L-alanine amidase OLIIENHM_00636 1440774.Y900_013305 1.2e-104 386.3 Mycobacteriaceae Bacteria 234JU@1762,2GNNB@201174,COG3153@1,COG3153@2 NA|NA|NA S acetyltransferase OLIIENHM_00637 1440774.Y900_013310 1.2e-140 506.1 Mycobacteriaceae parB GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005694,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0060187,GO:0071944 ko:K03497 ko00000,ko03000,ko03036,ko04812 Bacteria 234XF@1762,2GNRN@201174,COG1475@1,COG1475@2 NA|NA|NA K Belongs to the ParB family OLIIENHM_00638 931627.MycrhDRAFT_2283 2.8e-144 518.1 Mycobacteriaceae parA ko:K03496 ko00000,ko03036,ko04812 Bacteria 233AJ@1762,2GMU7@201174,COG1192@1,COG1192@2 NA|NA|NA D chromosome partitioning OLIIENHM_00639 931627.MycrhDRAFT_2284 1.3e-80 306.2 Mycobacteriaceae rsmG GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 ko:K03501 ko00000,ko01000,ko03009,ko03036 Bacteria 234TV@1762,2GM9Z@201174,COG0357@1,COG0357@2 NA|NA|NA J Specifically methylates the N7 position of a guanine in 16S rRNA OLIIENHM_00640 1449048.JQKU01000005_gene4594 2.6e-73 281.6 Mycobacteriaceae jag ko:K06346,ko:K09749 ko00000 Bacteria 235EK@1762,2GPZK@201174,COG1847@1,COG1847@2 NA|NA|NA S RNA-binding protein OLIIENHM_00641 318424.EU78_00255 9.6e-152 543.1 Mycobacteriaceae yidC GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 Bacteria 232HE@1762,2GJBU@201174,COG0706@1,COG0706@2 NA|NA|NA U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins (By similarity) OLIIENHM_00642 164757.Mjls_5787 2.3e-31 141.4 Mycobacteriaceae yidD ko:K08998 ko00000 Bacteria 23AKH@1762,2GQZG@201174,COG0759@1,COG0759@2 NA|NA|NA S Could be involved in insertion of integral membrane proteins into the membrane OLIIENHM_00643 931627.MycrhDRAFT_2288 7.4e-34 151.0 Mycobacteriaceae rnpA GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031123,GO:0031404,GO:0031974,GO:0031981,GO:0032991,GO:0033204,GO:0034414,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042301,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043168,GO:0043170,GO:0043199,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043628,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901681,GO:1902494,GO:1902555,GO:1905267,GO:1905348,GO:1990904 3.1.26.5 ko:K03536,ko:K08998 ko00000,ko01000,ko03016 Bacteria 23AQQ@1762,2GR42@201174,COG0594@1,COG0594@2 NA|NA|NA J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme OLIIENHM_00644 1440774.Y900_013340 4e-239 833.9 Mycobacteriaceae dnaA GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006172,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009133,GO:0009135,GO:0009136,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009179,GO:0009180,GO:0009185,GO:0009188,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016311,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046031,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990837 ko:K02313 ko02020,ko04112,map02020,map04112 ko00000,ko00001,ko03032,ko03036 Bacteria 232TF@1762,2GJKI@201174,COG0593@1,COG0593@2 NA|NA|NA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids OLIIENHM_00645 1146883.BLASA_1083 5.7e-174 617.5 Frankiales Bacteria 2GZ8H@201174,4EWKX@85013,COG4584@1,COG4584@2 NA|NA|NA L Evidence 2b Function of strongly homologous gene OLIIENHM_00646 1032480.MLP_52140 4.1e-112 411.0 Propionibacteriales Bacteria 2H714@201174,4DS5V@85009,COG1484@1,COG1484@2 NA|NA|NA L IstB-like ATP binding protein OLIIENHM_00647 1194972.MVAC_08104 1.6e-51 208.4 Mycobacteriaceae tuf GO:0001666,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0008150,GO:0009628,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0019899,GO:0030312,GO:0035375,GO:0036293,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070482,GO:0071944 ko:K02358 ko00000,ko03012,ko03029,ko04147 Bacteria 233XN@1762,2GK4T@201174,COG0050@1,COG0050@2 NA|NA|NA J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis OLIIENHM_00649 1440774.Y900_018010 5.4e-83 314.3 Mycobacteriaceae Bacteria 233WD@1762,2EZZU@1,2GNV4@201174,33T3V@2 NA|NA|NA OLIIENHM_00650 1440774.Y900_018015 2.3e-124 451.8 Mycobacteriaceae Bacteria 23589@1762,2GRE4@201174,COG1028@1,COG1028@2 NA|NA|NA IQ Belongs to the short-chain dehydrogenases reductases (SDR) family OLIIENHM_00651 931627.MycrhDRAFT_1728 2.2e-130 471.9 Mycobacteriaceae mhpC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006082,GO:0006725,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016787,GO:0016822,GO:0016823,GO:0018771,GO:0019439,GO:0019622,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046164,GO:0046395,GO:0046435,GO:0052823,GO:0071704,GO:0072329,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616 3.7.1.14,3.7.1.17,3.7.1.8 ko:K05714,ko:K10222,ko:K16050 ko00360,ko00621,ko00984,ko01100,ko01120,ko01220,map00360,map00621,map00984,map01100,map01120,map01220 M00543,M00545 R02603,R02606,R05359,R05360,R05361,R06789,R09883 RC00475,RC00476,RC00752,RC00753,RC00757,RC01337,RC02018,RC02740 br01602,ko00000,ko00001,ko00002,ko01000 iECDH10B_1368.ECDH10B_1361 Bacteria 23F6Y@1762,2I2NR@201174,COG0596@1,COG0596@2 NA|NA|NA S Serine aminopeptidase, S33 OLIIENHM_00652 931627.MycrhDRAFT_1729 1.9e-249 868.2 Mycobacteriaceae 1.14.13.127 ko:K05712 ko00360,ko01120,ko01220,map00360,map01120,map01220 M00545 R06786,R06787 RC00236 ko00000,ko00001,ko00002,ko01000 Bacteria 234C7@1762,2GK88@201174,COG0654@1,COG0654@2 NA|NA|NA CH Catalyzes the insertion of one atom of molecular oxygen into position 2 of the phenyl ring of 3-(3- hydroxyphenyl)propionate (3-HPP) and hydroxycinnamic acid (3HCI) OLIIENHM_00653 318424.EU78_02290 5.7e-91 340.5 Mycobacteriaceae Bacteria 2357T@1762,2GKU3@201174,COG1309@1,COG1309@2 NA|NA|NA K tetR family OLIIENHM_00654 318424.EU78_02295 4.3e-101 374.4 Mycobacteriaceae 4.1.1.77,4.2.1.80 ko:K01617,ko:K02554 ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220 M00545,M00569 R02601,R02602,R04781,R05374 RC00750,RC00751,RC01213,RC02672 br01602,ko00000,ko00001,ko00002,ko01000 Bacteria 233KJ@1762,2GPBI@201174,COG3971@1,COG3971@2 NA|NA|NA Q hydratase OLIIENHM_00655 931627.MycrhDRAFT_1732 6.4e-139 500.4 Mycobacteriaceae mhpF 1.2.1.10 ko:K04073 ko00360,ko00362,ko00620,ko00621,ko00622,ko00650,ko01100,ko01120,ko01220,map00360,map00362,map00620,map00621,map00622,map00650,map01100,map01120,map01220 M00545,M00569 R00228,R01172 RC00004,RC00184,RC01195 br01602,ko00000,ko00001,ko00002,ko01000 Bacteria 2331S@1762,2GKBZ@201174,COG4569@1,COG4569@2 NA|NA|NA Q Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds OLIIENHM_00656 931627.MycrhDRAFT_1733 3.4e-159 567.8 Mycobacteriaceae mhpE GO:0003674,GO:0003824,GO:0008701,GO:0016829,GO:0016830,GO:0016833 4.1.3.39 ko:K01666 ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220 M00545,M00569 R00750 RC00307,RC00371 br01602,ko00000,ko00001,ko00002,ko01000 iECIAI39_1322.ECIAI39_0326,iEcSMS35_1347.EcSMS35_0383,iYL1228.KPN_02117 Bacteria 234AH@1762,2GJBI@201174,COG0119@1,COG0119@2 NA|NA|NA E Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds OLIIENHM_00657 468556.AQYG01000044_gene3742 9.3e-39 167.2 Gordoniaceae ygiM GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944 ko:K07184 ko00000 Bacteria 2GVYT@201174,4GFH0@85026,COG3103@1,COG4991@2 NA|NA|NA T sh3 domain protein OLIIENHM_00658 47839.CCAU010000007_gene2187 1.3e-33 149.4 Mycobacteriaceae GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044212,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 Bacteria 239YU@1762,2IFEY@201174,COG1846@1,COG1846@2 NA|NA|NA K Transcriptional regulator OLIIENHM_00659 47839.CCAU010000004_gene566 8.8e-37 160.6 Mycobacteriaceae Bacteria 235TC@1762,2BIE3@1,2I99P@201174,32CKE@2 NA|NA|NA OLIIENHM_00660 931627.MycrhDRAFT_2378 6.6e-149 533.9 Mycobacteriaceae Bacteria 232K2@1762,2GXK6@201174,COG0654@1,COG0654@2 NA|NA|NA CH COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases OLIIENHM_00661 931627.MycrhDRAFT_4262 3.2e-22 112.1 Mycobacteriaceae GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 Bacteria 232CV@1762,2GMGW@201174,COG1512@1,COG1512@2 NA|NA|NA M TPM domain OLIIENHM_00662 931627.MycrhDRAFT_1813 8.4e-62 243.0 Mycobacteriaceae cadI GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0050896 4.4.1.5 ko:K01759 ko00620,map00620 R02530 RC00004,RC00740 ko00000,ko00001,ko01000 Bacteria 238NS@1762,2IFUM@201174,COG0346@1,COG0346@2 NA|NA|NA E Glyoxalase bleomycin resistance protein dioxygenase OLIIENHM_00663 931627.MycrhDRAFT_1814 2.6e-45 188.0 Mycobacteriaceae ko:K03892 ko00000,ko03000 Bacteria 23A3S@1762,2IKP4@201174,COG0640@1,COG0640@2 NA|NA|NA K arsR family OLIIENHM_00664 419947.MRA_2671 3.2e-38 164.5 Mycobacteriaceae ko:K03892 ko00000,ko03000 Bacteria 23A4J@1762,2IQDH@201174,COG0640@1,COG0640@2 NA|NA|NA K Transcriptional regulator OLIIENHM_00665 931627.MycrhDRAFT_2509 2.8e-168 598.2 Mycobacteriaceae fadE2 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 Bacteria 233QZ@1762,2GKQI@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_00666 1380386.JIAW01000001_gene4916 3.2e-83 315.1 Mycobacteriaceae iphP 3.1.3.48 ko:K01104 ko00000,ko01000 Bacteria 235K2@1762,2GK28@201174,COG2365@1,COG2365@2 NA|NA|NA T COG2365 Protein tyrosine serine phosphatase OLIIENHM_00667 931627.MycrhDRAFT_2507 1.6e-53 215.7 Mycobacteriaceae yqgC ko:K09793 ko00000 Bacteria 2397M@1762,2IQDE@201174,COG2839@1,COG2839@2 NA|NA|NA S Protein of unknown function (DUF456) OLIIENHM_00668 1996.JOFO01000082_gene5908 1.9e-19 102.8 Actinobacteria argO GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015174,GO:0015181,GO:0015318,GO:0015711,GO:0015802,GO:0015807,GO:0015809,GO:0015849,GO:0015893,GO:0016020,GO:0022857,GO:0034220,GO:0042221,GO:0042493,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902023,GO:1903825,GO:1903826,GO:1905039,GO:1990822 ko:K06895 ko00000,ko02000 2.A.75.1 Bacteria 2I2KP@201174,COG1279@1,COG1279@2 NA|NA|NA S LysE type translocator OLIIENHM_00669 1370125.AUWT01000070_gene1602 3.7e-73 281.2 Mycobacteriaceae ko:K09967 ko00000 Bacteria 2342Q@1762,2GKI6@201174,COG3665@1,COG3665@2 NA|NA|NA S Domain of unknown function (DUF1989) OLIIENHM_00670 318424.EU78_00715 6.5e-115 420.6 Mycobacteriaceae 1.6.5.5 ko:K00344 ko00000,ko01000 Bacteria 233JD@1762,2GK7Y@201174,COG0604@1,COG0604@2 NA|NA|NA C alcohol dehydrogenase OLIIENHM_00671 1380386.JIAW01000001_gene4921 9.8e-139 499.6 Mycobacteriaceae Bacteria 236AX@1762,2GJ1F@201174,COG1028@1,COG1028@2 NA|NA|NA IQ Belongs to the short-chain dehydrogenases reductases (SDR) family OLIIENHM_00672 1440774.Y900_014185 1.7e-123 449.1 Mycobacteriaceae GO:0002682,GO:0002684,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136 Bacteria 234GY@1762,2GM4W@201174,COG3315@1,COG3315@2 NA|NA|NA Q Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity OLIIENHM_00673 1440774.Y900_014180 1.4e-50 206.1 Mycobacteriaceae luxT Bacteria 233P3@1762,2GNW0@201174,COG1309@1,COG1309@2 NA|NA|NA K tetR family OLIIENHM_00675 931627.MycrhDRAFT_2499 2.1e-66 258.8 Mycobacteriaceae Bacteria 238WW@1762,2IIZR@201174,COG1309@1,COG1309@2 NA|NA|NA K Transcriptional regulator OLIIENHM_00676 1440774.Y900_014165 9.7e-220 770.0 Mycobacteriaceae yccS_1 Bacteria 236YX@1762,2GN9U@201174,COG1289@1,COG1289@2 NA|NA|NA S Fusaric acid resistance protein-like OLIIENHM_00677 1440774.Y900_014155 2.6e-228 798.1 Mycobacteriaceae ptsI 2.7.3.9 ko:K08483 ko02060,map02060 ko00000,ko00001,ko01000,ko02000 8.A.7 Bacteria 232JE@1762,2GIZZ@201174,COG1080@1,COG1080@2 NA|NA|NA G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) OLIIENHM_00678 931627.MycrhDRAFT_2495 3e-102 378.3 Mycobacteriaceae fruR ko:K02081,ko:K03436 ko00000,ko03000 Bacteria 233RA@1762,2GKWM@201174,COG1349@1,COG1349@2 NA|NA|NA K DeoR C terminal sensor domain OLIIENHM_00679 931627.MycrhDRAFT_2494 5.2e-120 437.6 Mycobacteriaceae fruK GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006000,GO:0006001,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008443,GO:0008662,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019318,GO:0019320,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046835,GO:0071704,GO:1901575 2.7.1.11,2.7.1.56 ko:K00882,ko:K16370 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00345 R00756,R02071,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 iAF1260.b2168,iAPECO1_1312.APECO1_4386,iB21_1397.B21_02056,iEC042_1314.EC042_2401,iEC55989_1330.EC55989_2421,iECABU_c1320.ECABU_c24990,iECBD_1354.ECBD_1490,iECB_1328.ECB_02097,iECDH10B_1368.ECDH10B_2325,iECDH1ME8569_1439.ECDH1ME8569_2104,iECD_1391.ECD_02097,iECED1_1282.ECED1_2616,iECH74115_1262.ECH74115_3304,iECIAI1_1343.ECIAI1_2248,iECIAI39_1322.ECIAI39_2308,iECNA114_1301.ECNA114_2259,iECO103_1326.ECO103_2643,iECO111_1330.ECO111_2886,iECO26_1355.ECO26_3080,iECOK1_1307.ECOK1_2400,iECP_1309.ECP_2208,iECS88_1305.ECS88_2316,iECSE_1348.ECSE_2436,iECSF_1327.ECSF_2049,iECSP_1301.ECSP_3046,iECUMN_1333.ECUMN_2504,iECW_1372.ECW_m2369,iECs_1301.ECs3060,iEKO11_1354.EKO11_1586,iETEC_1333.ETEC_2303,iEcDH1_1363.EcDH1_1490,iEcHS_1320.EcHS_A2305,iEcSMS35_1347.EcSMS35_2315,iEcolC_1368.EcolC_1480,iG2583_1286.G2583_2711,iJO1366.b2168,iJR904.b2168,iLF82_1304.LF82_0744,iNRG857_1313.NRG857_11005,iPC815.YPO1299,iSBO_1134.SBO_2156,iSDY_1059.SDY_2316,iSFV_1184.SFV_2243,iSF_1195.SF2253,iSFxv_1172.SFxv_2486,iS_1188.S2382,iUMN146_1321.UM146_05955,iUMNK88_1353.UMNK88_2713,iUTI89_1310.UTI89_C2443,iWFL_1372.ECW_m2369,iY75_1357.Y75_RS11345,iZ_1308.Z3426,ic_1306.c2703 Bacteria 2356P@1762,2GK7E@201174,COG1105@1,COG1105@2 NA|NA|NA G Belongs to the carbohydrate kinase PfkB family OLIIENHM_00680 931627.MycrhDRAFT_2493 2.1e-269 934.9 Mycobacteriaceae fruA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090582 2.7.1.202,2.7.1.56 ko:K00882,ko:K02768,ko:K02769,ko:K02770,ko:K02806,ko:K11202 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273,M00306 R02071,R03232 RC00002,RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1 iEcSMS35_1347.EcSMS35_2314,iJN746.PP_0795,iSbBS512_1146.SbBS512_E0796 Bacteria 233QV@1762,2GJU4@201174,COG1299@1,COG1299@2,COG1445@1,COG1445@2,COG1762@1,COG1762@2 NA|NA|NA G PTS system, fructose subfamily, IIC OLIIENHM_00681 350054.Mflv_0753 1.1e-29 135.6 Mycobacteriaceae ptsH ko:K11189 ko00000,ko02000 4.A.2.1 Bacteria 23AKT@1762,2GQX6@201174,COG1925@1,COG1925@2 NA|NA|NA G HPr family OLIIENHM_00682 1449048.JQKU01000008_gene987 2.3e-194 684.9 Mycobacteriaceae fccB 1.8.5.4 ko:K17218 ko00920,map00920 R10152 RC03155 ko00000,ko00001,ko01000 Bacteria 233P7@1762,2GRTN@201174,COG0446@1,COG0446@2 NA|NA|NA S Pyridine nucleotide-disulphide oxidoreductase OLIIENHM_00683 1440774.Y900_014130 2.1e-215 755.0 Mycobacteriaceae blh Bacteria 236XH@1762,2GN50@201174,COG0491@1,COG0491@2,COG0607@1,COG0607@2 NA|NA|NA P PFAM beta-lactamase domain protein OLIIENHM_00684 1206744.BAGL01000124_gene6479 9.7e-29 132.5 Nocardiaceae ko:K21600 ko00000,ko03000 Bacteria 2IQ7U@201174,4G32F@85025,COG1937@1,COG1937@2 NA|NA|NA S Metal-sensitive transcriptional repressor OLIIENHM_00685 931627.MycrhDRAFT_2071 2.8e-119 434.9 Mycobacteriaceae yidA Bacteria 2349R@1762,2GP42@201174,COG0561@1,COG0561@2 NA|NA|NA S hydrolase OLIIENHM_00686 1209984.BN978_02435 3.5e-92 344.7 Mycobacteriaceae Bacteria 233J0@1762,2GKM6@201174,COG0204@1,COG0204@2 NA|NA|NA I Acyltransferase OLIIENHM_00687 258533.BN977_02652 7.5e-106 390.2 Mycobacteriaceae plsC 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 234ME@1762,2GKM6@201174,COG0204@1,COG0204@2 NA|NA|NA I Acyltransferase OLIIENHM_00688 1440774.Y900_012230 3.3e-278 963.8 Mycobacteriaceae 1.14.18.2 ko:K08080,ko:K14952 ko00520,ko05152,map00520,map05152 R01115,R01803 RC00157 ko00000,ko00001,ko01000 Bacteria 234RR@1762,2GP4N@201174,COG2146@1,COG2146@2,COG2220@1,COG2220@2 NA|NA|NA P Rieske 2Fe-2S OLIIENHM_00689 1440774.Y900_012235 4.6e-47 193.7 Mycobacteriaceae Bacteria 23A24@1762,2IKXK@201174,32XGI@2,arCOG09609@1 NA|NA|NA OLIIENHM_00690 931627.MycrhDRAFT_2077 1.4e-131 475.7 Mycobacteriaceae Bacteria 237IQ@1762,2DBB6@1,2I8EW@201174,2Z85M@2 NA|NA|NA OLIIENHM_00691 931627.MycrhDRAFT_2078 1.4e-208 732.3 Mycobacteriaceae serS GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 234J4@1762,2GIWP@201174,COG0172@1,COG0172@2 NA|NA|NA J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) OLIIENHM_00692 164757.Mjls_5411 4.9e-143 514.2 Mycobacteriaceae GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 Bacteria 235KX@1762,2BXNT@1,2H72W@201174,30VN0@2 NA|NA|NA S Septum formation OLIIENHM_00693 1078020.KEK_06695 3.7e-49 200.7 Mycobacteriaceae Bacteria 23A0S@1762,2IKXW@201174,COG3824@1,COG3824@2 NA|NA|NA S Zincin-like metallopeptidase OLIIENHM_00694 931627.MycrhDRAFT_0285 2.8e-170 605.5 Mycobacteriaceae Bacteria 232GB@1762,2GMIX@201174,COG2339@1,COG2339@2 NA|NA|NA S peptidase activity OLIIENHM_00695 1440774.Y900_012280 1.7e-218 765.4 Mycobacteriaceae ko:K08677 ko00000,ko01002 Bacteria 236KB@1762,2GMZ8@201174,COG4934@1,COG4934@2 NA|NA|NA O Peptidase S53 OLIIENHM_00696 1440774.Y900_017925 0.0 2109.7 Mycobacteriaceae rpoC GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 Bacteria 232M3@1762,2GKWF@201174,COG0086@1,COG0086@2 NA|NA|NA K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates OLIIENHM_00698 1128421.JAGA01000003_gene3110 1.1e-39 170.6 Bacteria 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 Bacteria COG1004@1,COG1004@2 NA|NA|NA M Belongs to the UDP-glucose GDP-mannose dehydrogenase family OLIIENHM_00699 298654.FraEuI1c_0160 1.5e-90 340.1 Bacteria nfrB GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.4.1.336 ko:K02359,ko:K11740,ko:K19003 ko00561,ko01100,ko04320,map00561,map01100,map04320 R02689 RC00005,RC00059 ko00000,ko00001,ko01000,ko01003 GT2 Bacteria COG1215@1,COG1215@2 NA|NA|NA M transferase activity, transferring glycosyl groups OLIIENHM_00700 298654.FraEuI1c_0161 8.2e-42 178.3 Bacteria algG 5.1.3.37 ko:K01795 ko00051,map00051 R08693 RC00509 ko00000,ko00001,ko01000 Bacteria COG3420@1,COG3420@2 NA|NA|NA P alginic acid biosynthetic process OLIIENHM_00701 1192034.CAP_8589 2.4e-43 182.6 Bacteria 4.2.2.3 ko:K01729 ko00051,map00051 R03706 ko00000,ko00001,ko01000 Bacteria COG3291@1,COG3291@2 NA|NA|NA S metallopeptidase activity OLIIENHM_00702 350058.Mvan_1261 3.9e-114 417.5 Mycobacteriaceae nfo GO:0000726,GO:0003674,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0008833,GO:0009987,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.21.2 ko:K01151 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 234Y8@1762,2GJJQ@201174,COG0648@1,COG0648@2 NA|NA|NA L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin OLIIENHM_00703 1440774.Y900_017945 3.4e-39 167.5 Mycobacteriaceae ko:K06995 ko00000 Bacteria 23AJY@1762,2IHPC@201174,COG3450@1,COG3450@2 NA|NA|NA S Protein of unknown function (DUF861) OLIIENHM_00704 1229780.BN381_290147 4.9e-24 118.2 Bacteria Bacteria 295J3@1,2ZSWK@2 NA|NA|NA OLIIENHM_00706 1157943.KB892705_gene2437 1.1e-301 1042.0 Mycobacteriaceae glpD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 R00848 RC00029 ko00000,ko00001,ko01000 Bacteria 232A2@1762,2GJKN@201174,COG0578@1,COG0578@2 NA|NA|NA C Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family OLIIENHM_00707 931627.MycrhDRAFT_0918 6e-234 816.6 Mycobacteriaceae lpdA GO:0000166,GO:0003674,GO:0003824,GO:0003955,GO:0005488,GO:0008150,GO:0008152,GO:0009405,GO:0016491,GO:0016651,GO:0016655,GO:0036094,GO:0043167,GO:0043168,GO:0044419,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0051704,GO:0055114,GO:0070401,GO:0097159,GO:1901265,GO:1901363 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2351U@1762,2GMP7@201174,COG1249@1,COG1249@2 NA|NA|NA C Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase OLIIENHM_00708 1209984.BN978_00590 2.6e-80 304.7 Mycobacteriaceae ykqA Bacteria 234AU@1762,2GJM9@201174,COG3703@1,COG3703@2 NA|NA|NA P AIG2-like family OLIIENHM_00709 931627.MycrhDRAFT_0916 2.6e-148 531.6 Mycobacteriaceae galE 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 Bacteria 23FA5@1762,2GMCW@201174,COG1087@1,COG1087@2 NA|NA|NA M Belongs to the NAD(P)-dependent epimerase dehydratase family OLIIENHM_00710 931627.MycrhDRAFT_0915 4.1e-196 690.6 Mycobacteriaceae amiA ko:K01436 ko00000,ko01000,ko01002 Bacteria 232S9@1762,2GK05@201174,COG1473@1,COG1473@2 NA|NA|NA S amidohydrolase OLIIENHM_00711 1440774.Y900_006835 3.9e-110 404.4 Mycobacteriaceae punA GO:0003674,GO:0003824,GO:0004731,GO:0006139,GO:0006152,GO:0006161,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009116,GO:0009120,GO:0009164,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0019439,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042453,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046121,GO:0046122,GO:0046124,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658 2.4.2.1 ko:K03783 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244 RC00033,RC00063,RC00122 ko00000,ko00001,ko01000 Bacteria 232K8@1762,2GKEI@201174,COG0005@1,COG0005@2 NA|NA|NA F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate OLIIENHM_00712 1380386.JIAW01000019_gene2290 2e-93 348.6 Mycobacteriaceae upp GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.9 ko:K00761 ko00240,ko01100,map00240,map01100 R00966 RC00063 ko00000,ko00001,ko01000 Bacteria 2365T@1762,2GPJE@201174,COG0035@1,COG0035@2 NA|NA|NA F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate OLIIENHM_00713 1440774.Y900_006865 1.2e-164 586.3 Mycobacteriaceae Bacteria 233T4@1762,28NCS@1,2GM5N@201174,2ZBFQ@2 NA|NA|NA OLIIENHM_00715 1440774.Y900_006895 5.2e-177 627.1 Mycobacteriaceae add GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659 3.5.4.4 ko:K01488 ko00230,ko01100,ko05340,map00230,map01100,map05340 R01560,R02556 RC00477 ko00000,ko00001,ko01000 iNJ661.Rv3313c Bacteria 235WI@1762,2GJ6I@201174,COG1816@1,COG1816@2 NA|NA|NA F adenosine deaminase OLIIENHM_00716 931627.MycrhDRAFT_0898 3e-58 231.1 Mycobacteriaceae sdhC ko:K00241,ko:K00247 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00149,M00150,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 Bacteria 23A0P@1762,2IKU7@201174,COG2009@1,COG2009@2 NA|NA|NA C succinate dehydrogenase OLIIENHM_00717 1440774.Y900_006915 7.4e-66 256.5 Mycobacteriaceae sdhD ko:K00242,ko:K00246 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00149,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002 Bacteria 2350H@1762,2GNKE@201174,COG2142@1,COG2142@2 NA|NA|NA C succinate dehydrogenase OLIIENHM_00718 557599.MKAN_15940 7.5e-154 550.1 Mycobacteriaceae desA3_2 1.14.19.3 ko:K00508 ko00591,ko01100,map00591,map01100 R07063 RC00917 ko00000,ko00001,ko01000,ko01004 Bacteria 232R3@1762,2GJKF@201174,COG3239@1,COG3239@2 NA|NA|NA I fatty acid desaturase OLIIENHM_00719 1265310.CCBD010000069_gene452 1.9e-165 588.6 Mycobacteriaceae Bacteria 2340S@1762,2GNFX@201174,COG1063@1,COG1063@2 NA|NA|NA E alcohol dehydrogenase OLIIENHM_00720 931627.MycrhDRAFT_2477 2.8e-58 231.5 Mycobacteriaceae 6.6.1.1 ko:K03404 ko00860,ko01100,ko01110,map00860,map01100,map01110 R03877 RC01012 ko00000,ko00001,ko01000 Bacteria 2396X@1762,2IIH1@201174,COG1240@1,COG1240@2 NA|NA|NA H Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX OLIIENHM_00721 931627.MycrhDRAFT_2478 1.9e-67 262.3 Mycobacteriaceae Bacteria 235JK@1762,2IKGF@201174,COG1309@1,COG1309@2 NA|NA|NA K Transcriptional regulator OLIIENHM_00722 1440774.Y900_014055 1.3e-190 672.5 Mycobacteriaceae cyp138 GO:0003674,GO:0003824,GO:0006629,GO:0008150,GO:0008152,GO:0008202,GO:0016125,GO:0016491,GO:0044238,GO:0055114,GO:0071704,GO:1901360,GO:1901615 1.14.14.1 ko:K00493 ko00071,ko00380,ko00627,ko01120,map00071,map00380,map00627,map01120 R03629,R04121,R05259 RC00046,RC01311 ko00000,ko00001,ko01000 Bacteria 2340R@1762,2GK4Z@201174,COG2124@1,COG2124@2 NA|NA|NA Q cytochrome P450 OLIIENHM_00723 875328.JDM601_1565 1.3e-61 243.0 Mycobacteriaceae GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016020,GO:0016740,GO:0016741,GO:0030312,GO:0032259,GO:0044424,GO:0044464,GO:0071944 Bacteria 235DX@1762,2I9JS@201174,COG0500@1,COG0500@2 NA|NA|NA Q Methyltransferase domain OLIIENHM_00725 318424.EU78_09275 5.4e-184 650.2 Mycobacteriaceae nrdE GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005971,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0015949,GO:0016020,GO:0016491,GO:0016725,GO:0016728,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0051063,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0071944,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 iAPECO1_1312.APECO1_3846,iYO844.BSU17380 Bacteria 232JS@1762,2GKX9@201174,COG0209@1,COG0209@2 NA|NA|NA F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides OLIIENHM_00726 710421.Mycch_4026 3.6e-61 241.1 Mycobacteriaceae Bacteria 238UG@1762,2IA3E@201174,COG3945@1,COG3945@2 NA|NA|NA S F420H(2)-dependent quinone reductase OLIIENHM_00727 318424.EU78_09280 2.3e-44 184.9 Mycobacteriaceae Bacteria 239AE@1762,2AMYP@1,2IHWN@201174,31CVU@2 NA|NA|NA OLIIENHM_00728 1370121.AUWS01000003_gene3341 1.3e-96 359.4 Mycobacteriaceae Bacteria 232AF@1762,2GMPE@201174,COG0583@1,COG0583@2 NA|NA|NA K Transcriptional regulator OLIIENHM_00729 103733.JNYO01000001_gene243 3.8e-91 342.0 Pseudonocardiales Bacteria 2I491@201174,4EFBH@85010,COG1233@1,COG1233@2 NA|NA|NA Q Flavin containing amine oxidoreductase OLIIENHM_00730 448385.sce7657 1.1e-17 96.3 Myxococcales Bacteria 1QACE@1224,2EC48@1,2WZA8@28221,2Z1PE@29,32SY8@2,434ZF@68525 NA|NA|NA OLIIENHM_00731 710686.Mycsm_02171 7e-182 643.3 Mycobacteriaceae 1.3.99.38 ko:K21401 ko00000,ko01000 Bacteria 232US@1762,2GKGH@201174,COG0644@1,COG0644@2 NA|NA|NA C geranylgeranyl reductase OLIIENHM_00732 1440774.Y900_004335 2.3e-99 368.6 Mycobacteriaceae Bacteria 233S6@1762,2GN0W@201174,COG1309@1,COG1309@2 NA|NA|NA K Transcriptional regulator OLIIENHM_00733 258533.BN977_05351 4.1e-173 614.0 Mycobacteriaceae nrdF GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0018130,GO:0019438,GO:0019637,GO:0030145,GO:0032991,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0090304,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990204 1.17.4.1 ko:K00526 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 iECNA114_1301.ECNA114_2708,iECSF_1327.ECSF_2473,iSFV_1184.SFV_2827,iSF_1195.SF2704,iSFxv_1172.SFxv_2966,iS_1188.S2890 Bacteria 234XW@1762,2GK46@201174,COG0208@1,COG0208@2 NA|NA|NA F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides OLIIENHM_00734 258533.BN977_05366 2.3e-35 154.8 Mycobacteriaceae Bacteria 23A88@1762,2E7QJ@1,2GR2A@201174,33260@2 NA|NA|NA S Protein of unknown function (DUF3349) OLIIENHM_00735 246196.MSMEI_1007 2.1e-167 595.1 Mycobacteriaceae adhC GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.1.1.1 ko:K13953,ko:K13979 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 Bacteria 232RS@1762,2GNVQ@201174,COG1064@1,COG1064@2 NA|NA|NA S alcohol dehydrogenase OLIIENHM_00736 1380386.JIAW01000032_gene3457 7.1e-118 430.3 Mycobacteriaceae Bacteria 237HC@1762,2GP05@201174,COG4221@1,COG4221@2 NA|NA|NA S KR domain OLIIENHM_00737 931627.MycrhDRAFT_1797 5.2e-132 477.6 Mycobacteriaceae fecB ko:K02016 ko02010,map02010 M00240 ko00000,ko00001,ko00002,ko02000 3.A.1.14 Bacteria 232T3@1762,2HU5V@201174,COG0614@1,COG0614@2 NA|NA|NA P Periplasmic binding protein OLIIENHM_00738 931627.MycrhDRAFT_4913 5.2e-301 1039.6 Mycobacteriaceae ctaD 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 Bacteria 233K8@1762,2GJHX@201174,COG0843@1,COG0843@2 NA|NA|NA C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B OLIIENHM_00739 1123023.JIAI01000028_gene4506 8e-141 507.3 Pseudonocardiales 3.1.2.6 ko:K01069 ko00620,map00620 R01736 RC00004,RC00137 ko00000,ko00001,ko01000 Bacteria 2GN50@201174,4DYE1@85010,COG0491@1,COG0491@2,COG0607@1,COG0607@2 NA|NA|NA P Zn-dependent hydrolase, glyoxylase OLIIENHM_00740 1078020.KEK_21620 4.2e-35 153.7 Mycobacteriaceae acyP GO:0003674,GO:0003824,GO:0003998,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016787,GO:0016817,GO:0016818,GO:0050896 3.6.1.7 ko:K01512 ko00620,ko00627,ko01120,map00620,map00627,map01120 R00317,R01421,R01515 RC00043 ko00000,ko00001,ko01000 iSB619.SA_RS07020,iSBO_1134.SBO_2263,iSF_1195.SF0969,iSFxv_1172.SFxv_1053,iS_1188.S1036 Bacteria 23AJ6@1762,2IQ4M@201174,COG1254@1,COG1254@2 NA|NA|NA C acylphosphatase OLIIENHM_00741 1440774.Y900_003620 7.4e-55 219.9 Mycobacteriaceae attW GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 239C1@1762,2IIK7@201174,COG1765@1,COG1765@2 NA|NA|NA O redox protein, regulator of disulfide bond formation OLIIENHM_00742 1440774.Y900_003625 2e-136 491.9 Mycobacteriaceae fpg GO:0000702,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0008152,GO:0008534,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034039,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 23633@1762,2GJNT@201174,COG0266@1,COG0266@2 NA|NA|NA L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates OLIIENHM_00743 875328.JDM601_2657 4.9e-91 340.9 Mycobacteriaceae rnc GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 Bacteria 232ZI@1762,2GKER@201174,COG0571@1,COG0571@2 NA|NA|NA J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism OLIIENHM_00744 1440774.Y900_003635 1.7e-66 258.8 Mycobacteriaceae yceD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 ko:K07040 ko00000 Bacteria 232I7@1762,2GJTS@201174,COG1399@1,COG1399@2 NA|NA|NA S Uncharacterized ACR, COG1399 OLIIENHM_00745 710685.MycrhN_5870 6.4e-38 164.5 Mycobacteriaceae GO:0008150,GO:0040007 Bacteria 234IY@1762,2I2NA@201174,COG3599@1,COG3599@2 NA|NA|NA D Cell division initiation protein OLIIENHM_00746 931627.MycrhDRAFT_1933 4.7e-74 283.9 Mycobacteriaceae coaD 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 2364S@1762,2GN1S@201174,COG0669@1,COG0669@2 NA|NA|NA F Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate OLIIENHM_00747 1440774.Y900_003650 7.9e-65 253.4 Mycobacteriaceae rsmD GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052913,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.171 ko:K08316 R07234 RC00003 ko00000,ko01000,ko03009 Bacteria 239DU@1762,2GQ3G@201174,COG0742@1,COG0742@2 NA|NA|NA L Methyltransferase OLIIENHM_00748 1440774.Y900_003660 5.8e-80 303.9 Mycobacteriaceae Bacteria 232SR@1762,2GMVK@201174,COG4243@1,COG4243@2 NA|NA|NA S Vitamin K epoxide reductase OLIIENHM_00749 1440774.Y900_003665 1.8e-91 342.4 Mycobacteriaceae pknE_1 Bacteria 233JE@1762,2GKH8@201174,COG1651@1,COG1651@2 NA|NA|NA O Thioredoxin OLIIENHM_00750 931627.MycrhDRAFT_1915 5.8e-141 507.3 Mycobacteriaceae lipN ko:K01066 ko00000,ko01000 Bacteria 234WY@1762,2GKX2@201174,COG0657@1,COG0657@2 NA|NA|NA I Alpha beta hydrolase OLIIENHM_00751 931627.MycrhDRAFT_1914 2.9e-103 381.7 Mycobacteriaceae dkgA GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 1.1.1.346 ko:K06221 R08878 RC00089 ko00000,ko01000 Bacteria 232WI@1762,2GJQ7@201174,COG0656@1,COG0656@2 NA|NA|NA S aldo keto reductase OLIIENHM_00752 1194972.MVAC_14043 1.1e-33 151.4 Mycobacteriaceae Bacteria 2372B@1762,2AR2R@1,2IF5W@201174,31GBU@2 NA|NA|NA OLIIENHM_00753 931627.MycrhDRAFT_1911 4.6e-86 324.3 Mycobacteriaceae ko:K09952 ko00000,ko01000,ko02048 Bacteria 232UH@1762,2I2MY@201174,COG3513@1,COG3513@2 NA|NA|NA L Protein of unknown function (DUF1524) OLIIENHM_00754 1440774.Y900_003700 7.1e-89 333.6 Mycobacteriaceae recG GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 ko:K03655 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 233IH@1762,2GKA3@201174,COG1200@1,COG1200@2 NA|NA|NA L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) OLIIENHM_00755 1440774.Y900_023220 1.7e-35 155.2 Mycobacteriaceae Bacteria 23A6I@1762,2E6TR@1,2IQF8@201174,331DK@2 NA|NA|NA OLIIENHM_00756 931627.MycrhDRAFT_4087 1.3e-238 832.4 Mycobacteriaceae ephD GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944 Bacteria 2358I@1762,2I45Y@201174,COG1028@1,COG1028@2,COG2267@1,COG2267@2 NA|NA|NA IQ Alpha beta hydrolase OLIIENHM_00757 479431.Namu_0482 1e-218 766.1 Actinobacteria ko:K03281,ko:K07085 ko00000 2.A.49,2.A.81 Bacteria 2GKDW@201174,COG0569@1,COG0569@2,COG2985@1,COG2985@2 NA|NA|NA P TrkA C-terminal domain protein OLIIENHM_00758 931627.MycrhDRAFT_4086 6.2e-221 773.5 Mycobacteriaceae pepA GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 Bacteria 233WJ@1762,2GJRB@201174,COG0260@1,COG0260@2 NA|NA|NA E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides OLIIENHM_00759 1440774.Y900_023235 2.8e-178 631.3 Mycobacteriaceae gcvT GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 Bacteria 235CE@1762,2GJ47@201174,COG0404@1,COG0404@2 NA|NA|NA E The glycine cleavage system catalyzes the degradation of glycine OLIIENHM_00760 1440774.Y900_023240 2.8e-186 657.9 Mycobacteriaceae ilvE GO:0000082,GO:0000096,GO:0000097,GO:0000278,GO:0003674,GO:0003824,GO:0004084,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0006082,GO:0006464,GO:0006520,GO:0006551,GO:0006555,GO:0006573,GO:0006790,GO:0006807,GO:0007049,GO:0008144,GO:0008150,GO:0008152,GO:0008283,GO:0008483,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009067,GO:0009081,GO:0009082,GO:0009083,GO:0009086,GO:0009098,GO:0009099,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016769,GO:0017144,GO:0018065,GO:0018193,GO:0018205,GO:0018272,GO:0018352,GO:0019538,GO:0019752,GO:0019842,GO:0022402,GO:0030170,GO:0036094,GO:0036211,GO:0040007,GO:0043094,GO:0043102,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044770,GO:0044772,GO:0044843,GO:0046394,GO:0046395,GO:0048037,GO:0050662,GO:0070279,GO:0071265,GO:0071267,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901607,GO:1903047 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 233K5@1762,2GKJ1@201174,COG0115@1,COG0115@2 NA|NA|NA E Branched-chain amino acid aminotransferase OLIIENHM_00761 931627.MycrhDRAFT_4081 9.7e-130 470.3 Mycobacteriaceae ydaM GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016740,GO:0016772,GO:0016779,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042802,GO:0043900,GO:0043902,GO:0044093,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051090,GO:0051091,GO:0051171,GO:0051252,GO:0052621,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:1900190,GO:1900192,GO:1900231,GO:1900233,GO:1903506,GO:2000112,GO:2001141 2.7.7.65 ko:K21088 ko02026,map02026 ko00000,ko00001,ko01000 Bacteria 235JY@1762,2IB0W@201174,COG2199@1,COG3706@2 NA|NA|NA T Diguanylate cyclase with PAS PAC sensor OLIIENHM_00762 164757.Mjls_3317 8.4e-70 270.4 Mycobacteriaceae cobS GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008818,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.8.26 ko:K02233 ko00860,ko01100,map00860,map01100 M00122 R05223,R11174 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 Bacteria 233T2@1762,2GKM4@201174,COG0368@1,COG0368@2 NA|NA|NA H Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate OLIIENHM_00763 1440774.Y900_023255 3.5e-138 498.0 Mycobacteriaceae cobT 2.4.2.21 ko:K00768 ko00860,ko01100,map00860,map01100 M00122 R04148 RC00033,RC00063 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv2207 Bacteria 234ZG@1762,2GJ16@201174,COG2038@1,COG2038@2 NA|NA|NA F Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) OLIIENHM_00764 1265310.CCBD010000050_gene2042 1.2e-54 219.5 Mycobacteriaceae cobU 2.4.2.21,2.7.1.156,2.7.7.62 ko:K00768,ko:K02231 ko00860,ko01100,map00860,map01100 M00122 R04148,R05221,R05222,R06558 RC00002,RC00033,RC00063,RC00428 ko00000,ko00001,ko00002,ko01000 Bacteria 23984@1762,2GM8Q@201174,COG2087@1,COG2087@2 NA|NA|NA H cobinamide kinase OLIIENHM_00765 547163.BN979_06193 1.2e-52 213.4 Mycobacteriaceae GO:0008150,GO:0009605,GO:0009607,GO:0020012,GO:0030682,GO:0042783,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0075136 Bacteria 234BB@1762,2AN86@1,2HWWU@201174,31D67@2 NA|NA|NA S Protein of unknown function (DUF3043) OLIIENHM_00766 931627.MycrhDRAFT_4076 4.4e-120 438.0 Mycobacteriaceae glxK GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 2.7.1.165 ko:K00865 ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130 R08572 RC00002,RC00428 ko00000,ko00001,ko01000 Bacteria 2357H@1762,2GKHX@201174,COG1929@1,COG1929@2 NA|NA|NA G Belongs to the glycerate kinase type-1 family OLIIENHM_00767 1209984.BN978_00430 7.4e-175 620.2 Mycobacteriaceae aroA GO:0003674,GO:0003824,GO:0003866,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:0071944,GO:1901576 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 Bacteria 233CZ@1762,2GJKX@201174,COG0128@1,COG0128@2 NA|NA|NA E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate OLIIENHM_00768 1440774.Y900_006275 2.7e-139 501.5 Mycobacteriaceae rsgA 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 Bacteria 232BN@1762,2GJ37@201174,COG1162@1,COG1162@2 NA|NA|NA S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit OLIIENHM_00769 1440774.Y900_006280 1.5e-126 459.1 Mycobacteriaceae dkgA GO:0003674,GO:0003824,GO:0004033,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0008106,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0042180,GO:0042182,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0051596,GO:0055114,GO:0071704,GO:1901575 1.1.1.346 ko:K06221 R08878 RC00089 ko00000,ko01000 iECH74115_1262.ECH74115_4323,iECSP_1301.ECSP_3988 Bacteria 23525@1762,2GJQ7@201174,COG0656@1,COG0656@2 NA|NA|NA S Aldo keto OLIIENHM_00770 1150599.MPHLEI_02168 1.1e-172 612.8 Mycobacteriaceae desA3 GO:0001676,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016020,GO:0016053,GO:0016213,GO:0016215,GO:0016491,GO:0016705,GO:0016717,GO:0019752,GO:0032787,GO:0042759,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:0072330,GO:1901576 1.14.19.3 ko:K00508 ko00591,ko01100,map00591,map01100 R07063 RC00917 ko00000,ko00001,ko01000,ko01004 Bacteria 235HN@1762,2GJKF@201174,COG3239@1,COG3239@2 NA|NA|NA I fatty acid desaturase OLIIENHM_00771 931627.MycrhDRAFT_1085 4.8e-151 540.8 Mycobacteriaceae GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0070402,GO:0097159,GO:1901265,GO:1901363 Bacteria 235AP@1762,2GJSW@201174,COG1018@1,COG1018@2 NA|NA|NA C Oxidoreductase FAD-binding domain OLIIENHM_00772 1440774.Y900_006295 3.3e-62 244.6 Mycobacteriaceae Bacteria 238SP@1762,2DRWJ@1,2IFAY@201174,32URV@2 NA|NA|NA OLIIENHM_00773 931627.MycrhDRAFT_1083 1.3e-127 462.6 Mycobacteriaceae ppk2 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005525,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006183,GO:0006464,GO:0006468,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009889,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0030808,GO:0031323,GO:0031326,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0036211,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044403,GO:0044419,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046777,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051704,GO:0055086,GO:0062012,GO:0065007,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0080090,GO:0090407,GO:0097159,GO:0097367,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.4.1 ko:K22468 ko00190,ko03018,map00190,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 2334P@1762,2GKRN@201174,COG2326@1,COG2326@2 NA|NA|NA S polyphosphate kinase OLIIENHM_00774 931627.MycrhDRAFT_1082 3.6e-207 727.6 Mycobacteriaceae tgs3 GO:0000302,GO:0001666,GO:0003674,GO:0003824,GO:0004144,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0006638,GO:0006639,GO:0006641,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019432,GO:0030312,GO:0036293,GO:0040007,GO:0042221,GO:0042493,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0044464,GO:0045017,GO:0046460,GO:0046463,GO:0046486,GO:0047196,GO:0050896,GO:0051704,GO:0070482,GO:0071704,GO:0071731,GO:0071944,GO:0097366,GO:1901576,GO:1901698,GO:1901700 2.3.1.20 ko:K00635 ko00561,ko01100,map00561,map01100 M00089 R02251 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 Bacteria 232IC@1762,2HEFF@201174,COG1020@1,COG1020@2 NA|NA|NA I Belongs to the long-chain O-acyltransferase family OLIIENHM_00775 1440774.Y900_006310 6.9e-33 147.1 Mycobacteriaceae Bacteria 23A78@1762,2DPN9@1,2IRKR@201174,332RH@2 NA|NA|NA OLIIENHM_00776 931627.MycrhDRAFT_1080 5.5e-165 587.4 Mycobacteriaceae secA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030312,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 Bacteria 2345N@1762,2GIRT@201174,COG0653@1,COG0653@2 NA|NA|NA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane OLIIENHM_00777 931627.MycrhDRAFT_5306 8.3e-93 346.7 Mycobacteriaceae safC GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 Bacteria 232T5@1762,2GPEV@201174,COG4122@1,COG4122@2 NA|NA|NA S O-Methyltransferase OLIIENHM_00778 1172186.KB911462_gene356 3.7e-204 718.0 Mycobacteriaceae yfbS GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 237UM@1762,2HQSV@201174,COG0471@1,COG0471@2 NA|NA|NA P Sodium:sulfate symporter transmembrane region OLIIENHM_00779 931627.MycrhDRAFT_5312 1.3e-78 299.3 Mycobacteriaceae Bacteria 232CS@1762,28JRZ@1,2H9EF@201174,2Z9HI@2 NA|NA|NA S Domain of unknown function (DUF4126) OLIIENHM_00780 246196.MSMEI_4953 5.5e-204 716.8 Mycobacteriaceae glgC GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008878,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0070566,GO:0071704,GO:1901576 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2768 Bacteria 23450@1762,2I2EF@201174,COG0448@1,COG0448@2 NA|NA|NA H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans OLIIENHM_00781 931627.MycrhDRAFT_5317 1.9e-182 645.2 Mycobacteriaceae glgA GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901576 2.4.1.342 ko:K16148 ko00500,ko01100,map00500,map01100 R02421,R11530 RC00005,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 GT4 Bacteria 232KZ@1762,2I2EE@201174,COG0297@1,COG0297@2 NA|NA|NA G Glycogen synthase OLIIENHM_00782 1370120.AUWR01000051_gene1710 2.5e-22 110.5 Mycobacteriaceae Bacteria 23B6B@1762,2E39N@1,2GQFF@201174,32Y97@2 NA|NA|NA S Protein of unknown function (DUF3117) OLIIENHM_00783 1440774.Y900_019440 1.4e-68 265.8 Mycobacteriaceae tag 3.2.2.20 ko:K01246 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 235TK@1762,2IFH0@201174,COG2818@1,COG2818@2 NA|NA|NA L DNA-3-methyladenine glycosylase I OLIIENHM_00784 1440774.Y900_019435 3.6e-31 141.0 Mycobacteriaceae Bacteria 239WS@1762,2HI12@201174,COG3599@1,COG3599@2 NA|NA|NA D regulation of cell shape OLIIENHM_00785 1150599.MPHLEI_15086 5.2e-138 497.3 Mycobacteriaceae gpgS GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006011,GO:0006139,GO:0006725,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0009225,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0034641,GO:0040007,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046872,GO:0046983,GO:0055086,GO:0071704,GO:1901135,GO:1901360 2.4.1.266 ko:K13693 ko00000,ko01000,ko01003 GT81 Bacteria 232KP@1762,2I2NK@201174,COG0463@1,COG0463@2 NA|NA|NA M glucosyl-3-phosphoglycerate synthase OLIIENHM_00786 1440774.Y900_019425 3.9e-143 514.2 Mycobacteriaceae folP2 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 Bacteria 234IV@1762,2GJNI@201174,COG0294@1,COG0294@2 NA|NA|NA H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives OLIIENHM_00787 1440774.Y900_019420 7.3e-261 906.4 Mycobacteriaceae fadD6 ko:K00666 ko00000,ko01000,ko01004 Bacteria 2364I@1762,2GKZ6@201174,COG0318@1,COG0318@2 NA|NA|NA IQ Activates fatty acids by binding to coenzyme A OLIIENHM_00788 931627.MycrhDRAFT_5324 2.6e-82 311.6 Mycobacteriaceae yvdD GO:0003674,GO:0003824,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009308,GO:0009690,GO:0009691,GO:0009987,GO:0010817,GO:0016787,GO:0016798,GO:0016799,GO:0034754,GO:0042445,GO:0042446,GO:0044237,GO:0044249,GO:0046483,GO:0065007,GO:0065008,GO:0071704,GO:1901564 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 Bacteria 235UE@1762,2GMM1@201174,COG1611@1,COG1611@2 NA|NA|NA S Cytokinin riboside 5'-monophosphate phosphoribohydrolase OLIIENHM_00789 1440774.Y900_019410 1.8e-208 732.6 Mycobacteriaceae Bacteria 232BK@1762,2GM03@201174,COG2909@1,COG2909@2 NA|NA|NA K luxR family OLIIENHM_00790 1440774.Y900_019405 8.2e-162 576.6 Mycobacteriaceae dapE GO:0008150,GO:0040007 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 Bacteria 232AH@1762,2GK09@201174,COG0624@1,COG0624@2 NA|NA|NA E succinyl-diaminopimelate desuccinylase OLIIENHM_00791 931627.MycrhDRAFT_5327 1.1e-151 542.7 Mycobacteriaceae dapD GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008666,GO:0016020,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016749,GO:0030312,GO:0031402,GO:0031420,GO:0040007,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0048037,GO:0050662,GO:0071944 2.3.1.117 ko:K00674 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04365 RC00004,RC01136 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1201c Bacteria 23387@1762,2GIZ9@201174,COG2171@1,COG2171@2 NA|NA|NA E Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA OLIIENHM_00792 1440774.Y900_019390 8.3e-49 199.5 Mycobacteriaceae Bacteria 23A96@1762,2GMTB@201174,COG0346@1,COG0346@2 NA|NA|NA E lactoylglutathione lyase activity OLIIENHM_00793 1440774.Y900_019385 3e-217 761.1 Mycobacteriaceae fadD36 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0051087 ko:K12429,ko:K18660,ko:K18661 ko00280,map00280 R03383 RC00004,RC00137 ko00000,ko00001,ko01000,ko01004 Bacteria 232P7@1762,2GIUC@201174,COG0318@1,COG0318@2 NA|NA|NA IQ Activates fatty acids by binding to coenzyme A OLIIENHM_00794 931627.MycrhDRAFT_5331 1.8e-63 248.8 Mycobacteriaceae Bacteria 239EI@1762,2BFCU@1,2IESH@201174,32965@2 NA|NA|NA OLIIENHM_00796 931627.MycrhDRAFT_0422 1.4e-180 639.0 Mycobacteriaceae dcaA ko:K06446 ko00930,ko01100,ko01120,map00930,map01100,map01120 R06943 RC00052 ko00000,ko00001,ko01000 Bacteria 234NK@1762,2GIX8@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_00798 710687.KI912270_gene3775 3.3e-148 531.2 Mycobacteriaceae Bacteria 2380S@1762,2EP1Y@1,2IC2I@201174,33GNT@2 NA|NA|NA OLIIENHM_00799 1299327.I546_6896 1.1e-78 299.3 Mycobacteriaceae Bacteria 238HC@1762,2IQFY@201174,COG3311@1,COG3311@2 NA|NA|NA K Helix-turn-helix domain OLIIENHM_00800 931627.MycrhDRAFT_0411 1.4e-91 342.4 Mycobacteriaceae Bacteria 239MB@1762,2INYY@201174,COG1569@1,COG1569@2 NA|NA|NA S PIN domain OLIIENHM_00802 1370125.AUWT01000029_gene737 2.3e-84 318.5 Mycobacteriaceae Bacteria 2341Y@1762,2AQS6@1,2I9R6@201174,31G00@2 NA|NA|NA OLIIENHM_00803 710687.KI912270_gene3778 2.2e-210 738.0 Mycobacteriaceae Bacteria 23B9Y@1762,2IAJ1@201174,COG2856@1,COG2856@2 NA|NA|NA E IrrE N-terminal-like domain OLIIENHM_00804 710687.KI912270_gene3779 5.1e-76 290.4 Mycobacteriaceae ko:K18828 ko00000,ko01000,ko02048,ko03016 Bacteria 23AGT@1762,2ID5E@201174,COG1487@1,COG1487@2 NA|NA|NA S Domain of unknown function (DUF4411) OLIIENHM_00805 1077974.GOEFS_085_00020 0.0 1192.6 Gordoniaceae hsdM 2.1.1.72 ko:K03427 ko00000,ko01000,ko02048 Bacteria 2GKAQ@201174,4GCU6@85026,COG0286@1,COG0286@2 NA|NA|NA V HsdM N-terminal domain OLIIENHM_00806 1077974.GOEFS_083_00010 2.9e-120 438.7 Gordoniaceae hsdS 3.1.21.3 ko:K01154 ko00000,ko01000,ko02048 Bacteria 2ICQT@201174,4GFJA@85026,COG0732@1,COG0732@2 NA|NA|NA V Type I restriction modification DNA specificity domain OLIIENHM_00807 710687.KI912270_gene3782 0.0 1928.7 Mycobacteriaceae hsdR 3.1.21.3 ko:K01153 ko00000,ko01000,ko02048 Bacteria 2364X@1762,2HI69@201174,COG0610@1,COG0610@2 NA|NA|NA L Type I restriction enzyme R protein N terminus (HSDR_N) OLIIENHM_00808 1077974.GOEFS_083_00040 9.5e-19 99.0 Actinobacteria Bacteria 2DDN3@1,2GT82@201174,2ZIMQ@2 NA|NA|NA K Helix-turn-helix XRE-family like proteins OLIIENHM_00809 710687.KI912270_gene3783 7.6e-68 263.1 Mycobacteriaceae 3.6.1.55 ko:K03574 ko00000,ko01000,ko03400 Bacteria 23F33@1762,2IFGP@201174,COG1051@1,COG1051@2 NA|NA|NA F may be an ADP-ribose pyrophosphatase - involved DNA replication, recombination, and repair OLIIENHM_00810 931627.MycrhDRAFT_0402 1.1e-125 456.1 Mycobacteriaceae korSA ko:K03710 ko00000,ko03000 Bacteria 23846@1762,2GKW8@201174,COG2188@1,COG2188@2 NA|NA|NA K UTRA OLIIENHM_00811 931627.MycrhDRAFT_0401 6.6e-64 250.0 Mycobacteriaceae Bacteria 238R8@1762,2DPM0@1,2INHW@201174,332KG@2 NA|NA|NA OLIIENHM_00812 710687.KI912270_gene3786 9.4e-111 406.4 Mycobacteriaceae ko:K03466 ko00000,ko03036 3.A.12 Bacteria 2357D@1762,2GJA3@201174,COG1674@1,COG1674@2 NA|NA|NA D ATP binding P-loop motif. it is found in the FtsK cell division protein from E. coli and the stage III sporulation protein E SpoIIIE, which has roles in regulation of prespore specific gene expression in B. subtilis. a mutation in FtsK causes a temperature sensitive block in cell division and it is involved in peptidoglycan synthesis or modification. the SpoIIIE protein is implicated in intercellular chromosomal DNA transfer OLIIENHM_00813 710687.KI912270_gene3787 3.3e-39 167.5 Mycobacteriaceae Bacteria 23BPT@1762,2B32N@1,2GW1P@201174,31VQA@2 NA|NA|NA OLIIENHM_00814 710687.KI912270_gene3788 5.7e-33 146.4 Mycobacteriaceae Bacteria 23AUF@1762,2BFS0@1,2IR2F@201174,329KT@2 NA|NA|NA OLIIENHM_00815 362242.MUL_0529 2.7e-208 731.1 Mycobacteriaceae Bacteria 236P7@1762,2HD2H@201174,COG4974@1,COG4974@2 NA|NA|NA L Belongs to the 'phage' integrase family OLIIENHM_00820 931627.MycrhDRAFT_0391 5.5e-25 120.9 Mycobacteriaceae Bacteria 239VM@1762,2ATDQ@1,2IIHW@201174,31IX0@2 NA|NA|NA OLIIENHM_00821 931627.MycrhDRAFT_0388 5e-171 607.1 Mycobacteriaceae desA1 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0030312,GO:0040007,GO:0043207,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071944,GO:0075136 1.14.19.11,1.14.19.2,1.14.19.26 ko:K03921 ko00061,ko01040,ko01212,map00061,map01040,map01212 R03370,R08161,R11108,R11109 RC00917 ko00000,ko00001,ko01000,ko01004 Bacteria 232ZP@1762,2GKGZ@201174,COG0208@1,COG0208@2 NA|NA|NA F desaturase OLIIENHM_00822 1440774.Y900_009495 3.7e-183 647.5 Mycobacteriaceae dus GO:0008150,GO:0010565,GO:0019216,GO:0019217,GO:0019222,GO:0031323,GO:0050789,GO:0050794,GO:0062012,GO:0065007,GO:0080090 Bacteria 232V6@1762,2GJ8I@201174,COG0042@1,COG0042@2 NA|NA|NA J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines OLIIENHM_00823 931627.MycrhDRAFT_0386 1.1e-206 726.5 Mycobacteriaceae Bacteria 2353X@1762,2GJM3@201174,COG1316@1,COG1316@2 NA|NA|NA K cell envelope-related transcriptional attenuator OLIIENHM_00826 931627.MycrhDRAFT_4640 3.5e-111 407.9 Mycobacteriaceae ppgK GO:0003674,GO:0003824,GO:0004340,GO:0004396,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0040007,GO:0044237,GO:0044238,GO:0044262,GO:0046835,GO:0047330,GO:0051156,GO:0071704,GO:1901135 2.7.1.2,2.7.1.63 ko:K00845,ko:K00886 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786,R02187,R02189 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 233KN@1762,2GJA0@201174,COG1940@1,COG1940@2 NA|NA|NA G catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor OLIIENHM_00827 931627.MycrhDRAFT_4641 2.8e-91 342.0 Mycobacteriaceae suhB GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0042578,GO:0043167,GO:0043169,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0046872,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 Bacteria 23395@1762,2GJQE@201174,COG0483@1,COG0483@2 NA|NA|NA G Inositol monophosphatase OLIIENHM_00828 931627.MycrhDRAFT_4642 1.5e-83 315.8 Mycobacteriaceae Bacteria 234Y7@1762,2E1BJ@1,2I9PK@201174,32WRF@2 NA|NA|NA S LytR cell envelope-related transcriptional attenuator OLIIENHM_00829 1209984.BN978_05125 2.2e-45 188.0 Mycobacteriaceae Bacteria 239ZY@1762,2ATJW@1,2IKN0@201174,31J3Z@2 NA|NA|NA S Domain of unknown function (DUF4193) OLIIENHM_00830 931627.MycrhDRAFT_4644 1.8e-70 271.9 Mycobacteriaceae Bacteria 238V0@1762,2E4C2@1,2I89W@201174,32TEI@2 NA|NA|NA S Protein of unknown function (DUF3093) OLIIENHM_00831 1440774.Y900_002435 1.2e-71 275.8 Mycobacteriaceae dut GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23,4.1.1.36,6.3.2.5 ko:K01520,ko:K13038 ko00240,ko00770,ko00983,ko01100,map00240,map00770,map00983,map01100 M00053,M00120 R02100,R03269,R04231,R11896 RC00002,RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000,ko03400 Bacteria 238NQ@1762,2IHYY@201174,COG0756@1,COG0756@2 NA|NA|NA F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA OLIIENHM_00832 1440774.Y900_002430 7.6e-85 320.5 Mycobacteriaceae Bacteria 23663@1762,28J4D@1,2I2E9@201174,30NZ9@2 NA|NA|NA S Protein of unknown function (DUF3710) OLIIENHM_00833 1265310.CCBD010000022_gene4307 1.3e-75 289.7 Mycobacteriaceae 1.1.1.122,1.1.1.65 ko:K00064,ko:K05275 ko00051,ko00053,ko00750,ko01100,ko01110,ko01120,map00051,map00053,map00750,map01100,map01110,map01120 M00114 R01708,R07675,R08926 RC00066,RC00116,RC00161 ko00000,ko00001,ko00002,ko01000 Bacteria 23422@1762,2I46H@201174,COG0667@1,COG0667@2 NA|NA|NA C Aldo Keto reductase OLIIENHM_00834 1440774.Y900_002420 2.8e-50 204.5 Mycobacteriaceae 3.6.4.12 ko:K03655 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 2398K@1762,2IHRX@201174,COG1200@1,COG1200@2 NA|NA|NA KL nucleic acid binding, OB-fold, tRNA helicase-type OLIIENHM_00835 931627.MycrhDRAFT_4649 2.6e-86 325.1 Mycobacteriaceae Bacteria 233HX@1762,2AVV0@1,2GJKP@201174,31MNQ@2 NA|NA|NA S Protein of unknown function (DUF3159) OLIIENHM_00836 1408452.JAGZ01000001_gene4019 3.2e-97 361.3 Mycobacteriaceae trkA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03499 ko00000,ko02000 2.A.38.1,2.A.38.4 Bacteria 235FZ@1762,2GKB9@201174,COG0569@1,COG0569@2 NA|NA|NA P Trk system potassium uptake protein OLIIENHM_00837 1440774.Y900_002400 2e-99 368.6 Mycobacteriaceae ceoB ko:K03499 ko00000,ko02000 2.A.38.1,2.A.38.4 Bacteria 232T6@1762,2GK4N@201174,COG0569@1,COG0569@2 NA|NA|NA P PFAM TrkA-N domain OLIIENHM_00838 931627.MycrhDRAFT_4653 2.5e-305 1054.3 Mycobacteriaceae Bacteria 23331@1762,2GK5V@201174,COG0531@1,COG0531@2 NA|NA|NA E amino acid OLIIENHM_00839 931627.MycrhDRAFT_4654 1.5e-158 565.8 Mycobacteriaceae sun GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0031974,GO:0031981,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0046483,GO:0070013,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:1901360 2.1.1.176 ko:K03500 ko00000,ko01000,ko03009 Bacteria 234AG@1762,2I46G@201174,COG0144@1,COG0144@2 NA|NA|NA J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family OLIIENHM_00840 1440774.Y900_002385 3.4e-186 657.9 Mycobacteriaceae nhaA ko:K03313 ko00000,ko02000 2.A.33.1 Bacteria 235FW@1762,2GKIK@201174,COG3004@1,COG3004@2 NA|NA|NA P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons OLIIENHM_00841 1440774.Y900_002380 0.0 1109.0 Mycobacteriaceae dxs GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008614,GO:0008615,GO:0008654,GO:0008661,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009240,GO:0009987,GO:0016740,GO:0016744,GO:0017144,GO:0018130,GO:0019288,GO:0019438,GO:0019637,GO:0019682,GO:0019752,GO:0019842,GO:0030145,GO:0030975,GO:0030976,GO:0032787,GO:0034641,GO:0036094,GO:0040007,GO:0042180,GO:0042181,GO:0042364,GO:0042723,GO:0042724,GO:0042816,GO:0042819,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:1901135,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663,GO:1901681 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 iEcSMS35_1347.EcSMS35_0456,iIT341.HP0354,iJN746.PP_0527 Bacteria 233VB@1762,2GMFA@201174,COG1154@1,COG1154@2 NA|NA|NA F Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) OLIIENHM_00842 931627.MycrhDRAFT_4657 1.3e-179 636.0 Mycobacteriaceae rnd 3.1.13.5 ko:K03684 ko00000,ko01000,ko03016 Bacteria 23366@1762,2GKNM@201174,COG0349@1,COG0349@2 NA|NA|NA J 3'-5' exonuclease OLIIENHM_00843 246196.MSMEI_2710 2.5e-90 338.2 Mycobacteriaceae Bacteria 2333J@1762,2AIF4@1,2GK8R@201174,318WM@2 NA|NA|NA S Protein of unknown function (DUF3000) OLIIENHM_00844 931627.MycrhDRAFT_4659 8.8e-166 589.7 Mycobacteriaceae hemE GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_0016 Bacteria 234D7@1762,2GMY6@201174,COG0407@1,COG0407@2 NA|NA|NA H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III OLIIENHM_00845 1440774.Y900_002355 6.9e-163 580.5 Mycobacteriaceae hemG 1.3.3.15,1.3.3.4 ko:K00231 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03222,R04178 RC00885 ko00000,ko00001,ko00002,ko01000 Bacteria 235U6@1762,2GMMA@201174,COG1232@1,COG1232@2 NA|NA|NA H Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX OLIIENHM_00846 931627.MycrhDRAFT_4661 3.7e-120 437.6 Mycobacteriaceae hemH GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 Bacteria 232YY@1762,2GK24@201174,COG3253@1,COG3253@2 NA|NA|NA S chlorite dismutase OLIIENHM_00847 1440774.Y900_002340 1e-182 647.1 Mycobacteriaceae Bacteria 23FCH@1762,2I2FR@201174,COG2199@1,COG2199@2 NA|NA|NA T PFAM Diguanylate phosphodiesterase, EAL domain OLIIENHM_00848 1440774.Y900_002340 7.3e-229 800.4 Mycobacteriaceae Bacteria 23FCH@1762,2I2FR@201174,COG2199@1,COG2199@2 NA|NA|NA T PFAM Diguanylate phosphodiesterase, EAL domain OLIIENHM_00849 1440774.Y900_002330 3.4e-68 264.2 Mycobacteriaceae msrB 1.8.4.12 ko:K07305 ko00000,ko01000 Bacteria 238KK@1762,2IHV0@201174,COG0229@1,COG0229@2 NA|NA|NA O Peptide-methionine (R)-S-oxide reductase OLIIENHM_00851 1440774.Y900_002325 2.3e-195 688.3 Mycobacteriaceae aftC GO:0008150,GO:0040007 2.4.2.47 ko:K16647 ko00000,ko01000,ko01003 Bacteria 232E9@1762,2F13Q@1,2I955@201174,33U55@2 NA|NA|NA S capsule organization OLIIENHM_00852 1440774.Y900_002320 1.1e-241 842.4 Mycobacteriaceae Bacteria 2353P@1762,2HCC5@201174,COG0596@1,COG0596@2 NA|NA|NA S Alpha beta hydrolase OLIIENHM_00853 1440774.Y900_002315 4.3e-69 268.1 Mycobacteriaceae ribD 1.1.1.193,3.5.4.26 ko:K00082,ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 Bacteria 233W3@1762,2GN2P@201174,COG1985@1,COG1985@2 NA|NA|NA H Riboflavin biosynthesis OLIIENHM_00854 710421.Mycch_2187 2.3e-161 575.1 Mycobacteriaceae ko:K06916 ko00000,ko03036 Bacteria 232K5@1762,2GNQA@201174,COG1485@1,COG1485@2 NA|NA|NA S AFG1-like ATPase OLIIENHM_00855 318424.EU78_11295 3.6e-49 201.4 Mycobacteriaceae trmD GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008080,GO:0008150,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0044424,GO:0044464,GO:0048583,GO:0050789,GO:0065007,GO:0080134,GO:1902882 2.1.1.228 ko:K00554 R00597 RC00003,RC00334 ko00000,ko01000,ko03016 Bacteria 238YQ@1762,2IMS5@201174,COG0454@1,COG0456@2 NA|NA|NA K acetyltransferase OLIIENHM_00857 931627.MycrhDRAFT_4685 1.1e-293 1015.4 Mycobacteriaceae fadD11_1 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 Bacteria 235IH@1762,2GIXQ@201174,COG1022@1,COG1022@2 NA|NA|NA I synthetase OLIIENHM_00858 710685.MycrhN_0494 4.5e-87 327.8 Mycobacteriaceae Bacteria 236ZI@1762,2I4PQ@201174,COG0204@1,COG0204@2 NA|NA|NA I Acyltransferase OLIIENHM_00859 931627.MycrhDRAFT_4686 1.3e-34 152.9 Mycobacteriaceae Bacteria 23AYE@1762,2AYE2@1,2IS3I@201174,31QH0@2 NA|NA|NA OLIIENHM_00860 931627.MycrhDRAFT_2084 1.7e-08 65.5 Mycobacteriaceae Bacteria 23BBG@1762,2BIUC@1,2GRW1@201174,32CFI@2 NA|NA|NA OLIIENHM_00864 1440774.Y900_026915 7.9e-216 756.5 Mycobacteriaceae lipT ko:K03929 ko00000,ko01000 CE10 Bacteria 233BC@1762,2GJCN@201174,COG2272@1,COG2272@2 NA|NA|NA I Belongs to the type-B carboxylesterase lipase family OLIIENHM_00865 1440774.Y900_026920 3.8e-72 278.1 Mycobacteriaceae lppI Bacteria 237R6@1762,2B0HC@1,2GN01@201174,31SUV@2 NA|NA|NA OLIIENHM_00866 1440774.Y900_026940 1.2e-17 95.1 Mycobacteriaceae Bacteria 23A5K@1762,2E5E7@1,2IN6X@201174,33065@2 NA|NA|NA OLIIENHM_00867 419947.MRA_2065 1.5e-55 221.9 Mycobacteriaceae rbpA GO:0001000,GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0008270,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042221,GO:0043167,GO:0043169,GO:0043175,GO:0045893,GO:0045935,GO:0046677,GO:0046872,GO:0046914,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070063,GO:0080090,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 Bacteria 23969@1762,2CNY9@1,2IMK6@201174,32SI2@2 NA|NA|NA K Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters OLIIENHM_00868 1157943.KB892705_gene962 1.4e-115 422.5 Mycobacteriaceae ppm1 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 R01009 RC00005 ko00000,ko00001,ko01000,ko01003 GT2 Bacteria 234JK@1762,2IPT1@201174,COG0463@1,COG0463@2 NA|NA|NA M PFAM Glycosyl transferase family 2 OLIIENHM_00869 1440774.Y900_026955 1.2e-147 529.6 Mycobacteriaceae lnt GO:0000030,GO:0003674,GO:0003824,GO:0004582,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0030312,GO:0035821,GO:0043207,GO:0044003,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052564,GO:0052572,GO:0070085,GO:0071704,GO:0071944,GO:0075136,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509 ko:K03820 ko00000,ko01000 GT2 iNJ661.Rv2051c Bacteria 234K4@1762,2GJ9F@201174,COG0815@1,COG0815@2 NA|NA|NA M Transfers the fatty acyl group on membrane lipoproteins OLIIENHM_00870 931627.MycrhDRAFT_3902 1.1e-59 236.1 Mycobacteriaceae lnt GO:0000030,GO:0003674,GO:0003824,GO:0004582,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0030312,GO:0035821,GO:0043207,GO:0044003,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052564,GO:0052572,GO:0070085,GO:0071704,GO:0071944,GO:0075136,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509 ko:K03820 ko00000,ko01000 GT2 iNJ661.Rv2051c Bacteria 234K4@1762,2GJ9F@201174,COG0815@1,COG0815@2 NA|NA|NA M Transfers the fatty acyl group on membrane lipoproteins OLIIENHM_00871 1440774.Y900_026960 2.4e-231 808.1 Mycobacteriaceae ytcJ Bacteria 2352V@1762,2GJVW@201174,COG1574@1,COG1574@2 NA|NA|NA S amidohydrolase OLIIENHM_00872 931627.MycrhDRAFT_3904 2.4e-33 148.7 Mycobacteriaceae fxsA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016021,GO:0031224,GO:0044425,GO:0044464,GO:0071944 2.3.3.13 ko:K01649,ko:K07006,ko:K07113 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2397J@1762,2IICY@201174,COG3030@1,COG3030@2,COG3871@1,COG3871@2 NA|NA|NA S Pyridoxamine 5-phosphate OLIIENHM_00873 931627.MycrhDRAFT_3905 1.3e-50 205.7 Mycobacteriaceae ko:K07006 ko00000 Bacteria 239BQ@1762,2IQDD@201174,COG3871@1,COG3871@2 NA|NA|NA S Pyridoxamine 5-phosphate OLIIENHM_00874 1440774.Y900_026980 0.0 2075.8 Mycobacteriaceae cobN 6.6.1.2 ko:K02230 ko00860,ko01100,map00860,map01100 R05227 RC02000 ko00000,ko00001,ko01000 iNJ661.Rv2062c Bacteria 23329@1762,2GK0U@201174,COG1429@1,COG1429@2 NA|NA|NA H cobaltochelatase, CobN subunit OLIIENHM_00875 1209984.BN978_06059 4.8e-17 94.4 Mycobacteriaceae Bacteria 23AZN@1762,2BHED@1,2IQIM@201174,32BGE@2 NA|NA|NA OLIIENHM_00876 1299327.I546_4628 2.3e-136 492.3 Mycobacteriaceae Bacteria 233PH@1762,2I9E2@201174,COG1721@1,COG1721@2 NA|NA|NA S Protein of unknown function DUF58 OLIIENHM_00877 931627.MycrhDRAFT_3912 3.5e-87 327.8 Mycobacteriaceae moxR3 ko:K03924 ko00000,ko01000 Bacteria 233MI@1762,2GK07@201174,COG0714@1,COG0714@2 NA|NA|NA S associated with various cellular activities OLIIENHM_00878 1348338.ADILRU_1152 2.6e-25 120.9 Microbacteriaceae Bacteria 2C7CU@1,2IRTH@201174,33J7G@2,4FSJC@85023 NA|NA|NA OLIIENHM_00880 1298863.AUEP01000020_gene3640 1e-37 162.5 Actinobacteria 2.3.1.128 ko:K03790 ko00000,ko01000,ko03009 Bacteria 2IQZC@201174,COG2329@1,COG2329@2 NA|NA|NA S Antibiotic biosynthesis monooxygenase OLIIENHM_00881 1223523.H340_07753 7.2e-71 273.9 Actinobacteria Bacteria 2GMX2@201174,COG3382@1,COG3382@2 NA|NA|NA S B3 4 domain OLIIENHM_00882 1121019.AUMN01000020_gene1650 4.5e-53 214.5 Micrococcaceae Bacteria 1WCG3@1268,2I3S1@201174,COG1476@1,COG1476@2 NA|NA|NA K Helix-turn-helix XRE-family like proteins OLIIENHM_00883 290340.AAur_3965 1.2e-78 300.1 Micrococcaceae rhtA GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015175,GO:0015179,GO:0015195,GO:0015238,GO:0015318,GO:0015562,GO:0015565,GO:0015711,GO:0015804,GO:0015807,GO:0015826,GO:0015849,GO:0015893,GO:0016020,GO:0022857,GO:0034220,GO:0034639,GO:0042221,GO:0042493,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903825,GO:1905039 ko:K11939 ko00000,ko02000 2.A.7.3.6 Bacteria 1W96S@1268,2GJKB@201174,COG5006@1,COG5006@2 NA|NA|NA S EamA-like transporter family OLIIENHM_00884 1385519.N801_09810 4.2e-164 584.3 Intrasporangiaceae Bacteria 2GS79@201174,4FF88@85021,COG3547@1,COG3547@2 NA|NA|NA L Transposase IS116/IS110/IS902 family OLIIENHM_00885 1150599.MPHLEI_11415 1.3e-65 255.8 Mycobacteriaceae lmrA ko:K06147 ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 235Z4@1762,2GITR@201174,COG1132@1,COG1132@2 NA|NA|NA V ABC transporter OLIIENHM_00886 478741.JAFS01000001_gene2221 1.4e-08 66.2 unclassified Verrucomicrobia Bacteria 37GZJ@326457,46Z0R@74201,COG5652@1,COG5652@2 NA|NA|NA S VanZ like family OLIIENHM_00887 350054.Mflv_2248 1.1e-13 82.0 Mycobacteriaceae Bacteria 23B78@1762,2APXI@1,2GR7N@201174,31F28@2 NA|NA|NA OLIIENHM_00888 1440774.Y900_019800 6.6e-127 460.7 Mycobacteriaceae cyaA 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 Bacteria 23294@1762,2GN02@201174,COG2114@1,COG2114@2 NA|NA|NA T Adenylate cyclase OLIIENHM_00889 931627.MycrhDRAFT_5190 1e-201 709.5 Mycobacteriaceae amiB2 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 Bacteria 2369H@1762,2GKPZ@201174,COG0154@1,COG0154@2 NA|NA|NA J Belongs to the amidase family OLIIENHM_00890 1440774.Y900_019785 2.2e-59 235.0 Mycobacteriaceae hit-1 ko:K02503 ko00000,ko04147 Bacteria 238N8@1762,2IHPT@201174,COG0537@1,COG0537@2 NA|NA|NA FG Hit family OLIIENHM_00891 258533.BN977_00338 9.2e-51 206.5 Mycobacteriaceae GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0030312,GO:0031406,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0070967,GO:0071944,GO:0097159,GO:0097367,GO:1901363 Bacteria 23F8S@1762,2I3P5@201174,COG3945@1,COG3945@2 NA|NA|NA S F420H(2)-dependent quinone reductase OLIIENHM_00892 931627.MycrhDRAFT_5194 8.3e-111 406.8 Mycobacteriaceae ung GO:0003674,GO:0003824,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033958,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360 3.2.2.27 ko:K21929 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 233MM@1762,2GK1I@201174,COG1573@1,COG1573@2 NA|NA|NA L Uracil-DNA glycosylase OLIIENHM_00893 931627.MycrhDRAFT_5195 7.3e-172 610.1 Mycobacteriaceae GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0015562,GO:0022857,GO:0042221,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0055085 Bacteria 2329X@1762,2HB3P@201174,COG2271@1,COG2271@2 NA|NA|NA G Major facilitator superfamily OLIIENHM_00894 419947.MRA_1451 6.2e-31 140.6 Mycobacteriaceae Bacteria 239IX@1762,2IIFF@201174,COG4276@1,COG4276@2 NA|NA|NA S Pfam Polyketide cyclase dehydrase and lipid transport OLIIENHM_00895 931627.MycrhDRAFT_5196 9.5e-221 772.7 Mycobacteriaceae 1.1.2.4,1.1.3.15 ko:K00102,ko:K00104 ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130 R00197,R00475 RC00042,RC00044 ko00000,ko00001,ko01000 Bacteria 232YC@1762,2GJ2T@201174,COG0277@1,COG0277@2 NA|NA|NA C FAD linked OLIIENHM_00896 1150599.MPHLEI_14876 3.4e-179 634.4 Mycobacteriaceae cyp130 GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0020037,GO:0030312,GO:0044464,GO:0046906,GO:0048037,GO:0071944,GO:0097159,GO:1901363 ko:K21119 ko00000,ko00199 Bacteria 232T9@1762,2GJ8V@201174,COG2124@1,COG2124@2 NA|NA|NA Q cytochrome p450 OLIIENHM_00897 931627.MycrhDRAFT_5255 1.5e-63 249.2 Mycobacteriaceae GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141 Bacteria 23681@1762,2GNAJ@201174,COG1309@1,COG1309@2 NA|NA|NA K Transcriptional regulator OLIIENHM_00898 1440774.Y900_019705 3.7e-170 604.4 Mycobacteriaceae Bacteria 236K0@1762,2GP6W@201174,COG1835@1,COG1835@2 NA|NA|NA I Acyltransferase OLIIENHM_00899 931627.MycrhDRAFT_5257 3.8e-248 864.0 Mycobacteriaceae deaD GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003724,GO:0003725,GO:0003727,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006417,GO:0006725,GO:0006807,GO:0006950,GO:0006996,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009987,GO:0010468,GO:0010501,GO:0010556,GO:0010557,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019439,GO:0022607,GO:0022613,GO:0022618,GO:0030312,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031330,GO:0032268,GO:0032270,GO:0033554,GO:0033592,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034655,GO:0042254,GO:0042255,GO:0042273,GO:0042623,GO:0043170,GO:0043487,GO:0043488,GO:0043489,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045934,GO:0046483,GO:0046700,GO:0048255,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051247,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0061013,GO:0065003,GO:0065007,GO:0065008,GO:0070035,GO:0070417,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097617,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902369,GO:1902373,GO:1903311,GO:1903312,GO:2000112 3.6.4.13 ko:K05592 ko03018,map03018 ko00000,ko00001,ko01000,ko03009,ko03019 Bacteria 233HA@1762,2GIUR@201174,COG0513@1,COG0513@2 NA|NA|NA JKL DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation OLIIENHM_00900 1194972.MVAC_16410 1.3e-52 212.2 Mycobacteriaceae lprE GO:0005575,GO:0005576 Bacteria 238MV@1762,2AS1M@1,2IFV5@201174,31HE2@2 NA|NA|NA S LppP/LprE lipoprotein OLIIENHM_00901 931627.MycrhDRAFT_3059 0.0 1374.8 Mycobacteriaceae mrpA GO:0003674,GO:0005215,GO:0005451,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015491,GO:0015672,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0098655,GO:0098660,GO:0098662,GO:0099516,GO:1902600 1.6.5.3 ko:K00341,ko:K05559,ko:K05565,ko:K05566 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000,ko02000 2.A.63.1,2.A.63.2,3.D.1 iSB619.SA_RS04630 Bacteria 232FV@1762,2GIT4@201174,COG1009@1,COG1009@2,COG2111@1,COG2111@2 NA|NA|NA CP Na H antiporter OLIIENHM_00902 931627.MycrhDRAFT_3058 1.6e-50 205.7 Mycobacteriaceae phaC 1.6.5.3 ko:K00340,ko:K05560,ko:K05567 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000,ko02000 2.A.63.1,2.A.63.2,3.D.1 Bacteria 238TJ@1762,2ISBC@201174,COG1006@1,COG1006@2 NA|NA|NA P Multisubunit Na H antiporter, MnhC subunit OLIIENHM_00903 1440774.Y900_016325 1.4e-236 825.5 Mycobacteriaceae mrpD GO:0003674,GO:0005215,GO:0005451,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015491,GO:0015672,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0098655,GO:0098660,GO:0098662,GO:0099516,GO:1902600 ko:K05568 ko00000,ko02000 2.A.63.1,2.A.63.2 iSB619.SA_RS04615 Bacteria 235AZ@1762,2HAC7@201174,COG0651@1,COG0651@2 NA|NA|NA CP Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit OLIIENHM_00904 1440774.Y900_016320 6.2e-54 217.2 Mycobacteriaceae mrpE ko:K05569 ko00000,ko02000 2.A.63.1,2.A.63.2 Bacteria 238SX@1762,2IQD6@201174,COG1863@1,COG1863@2 NA|NA|NA P antiporter OLIIENHM_00905 1209984.BN978_01486 5.4e-27 126.7 Mycobacteriaceae mrpF ko:K05570 ko00000,ko02000 2.A.63.1,2.A.63.2 Bacteria 23AMB@1762,2GRIE@201174,COG2212@1,COG2212@2 NA|NA|NA P PFAM multiple resistance and pH regulation protein F OLIIENHM_00906 350058.Mvan_0739 3e-35 154.5 Mycobacteriaceae mrpG ko:K05571 ko00000,ko02000 2.A.63.1,2.A.63.2 Bacteria 239YJ@1762,2IQXD@201174,COG1320@1,COG1320@2 NA|NA|NA P monovalent cation proton antiporter, MnhG PhaG subunit OLIIENHM_00907 931627.MycrhDRAFT_5260 1.5e-178 632.5 Mycobacteriaceae glcD2 GO:0000166,GO:0003674,GO:0003824,GO:0004457,GO:0004458,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006089,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016053,GO:0016491,GO:0016614,GO:0016898,GO:0019249,GO:0019516,GO:0019752,GO:0022900,GO:0022904,GO:0030447,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046394,GO:0048037,GO:0050660,GO:0050662,GO:0051990,GO:0055114,GO:0071704,GO:0071949,GO:0072330,GO:0097159,GO:0099615,GO:1901265,GO:1901363,GO:1901576,GO:1901615,GO:1901617 1.1.2.4 ko:K00102 ko00620,map00620 R00197 RC00044 ko00000,ko00001,ko01000 Bacteria 23433@1762,2GKI9@201174,COG0277@1,COG0277@2 NA|NA|NA C FAD linked OLIIENHM_00908 931627.MycrhDRAFT_5272 5.7e-211 740.3 Mycobacteriaceae GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 2367F@1762,2GIUM@201174,COG0477@1,COG0477@2 NA|NA|NA EGP Major facilitator superfamily OLIIENHM_00909 931627.MycrhDRAFT_5273 3.7e-122 444.9 Mycobacteriaceae ko:K03265 ko03015,map03015 ko00000,ko00001,ko03012,ko03019 Bacteria 233MF@1762,2GNN3@201174,COG1503@1,COG1503@2 NA|NA|NA J translation release factor activity OLIIENHM_00910 1440774.Y900_019615 4.3e-93 347.8 Mycobacteriaceae Bacteria 234J9@1762,2H5Y7@201174,COG1540@1,COG1540@2 NA|NA|NA S 5-oxoprolinase (ATP-hydrolyzing) activity OLIIENHM_00914 931627.MycrhDRAFT_2998 2e-56 225.3 Mycobacteriaceae Bacteria 239DX@1762,2IHQU@201174,COG1846@1,COG1846@2 NA|NA|NA K transcriptional OLIIENHM_00915 931627.MycrhDRAFT_3000 5.9e-152 543.9 Mycobacteriaceae Bacteria 233VP@1762,2GQVV@201174,COG4637@1,COG4637@2 NA|NA|NA S AAA domain, putative AbiEii toxin, Type IV TA system OLIIENHM_00916 931627.MycrhDRAFT_3002 2e-34 152.1 Mycobacteriaceae Bacteria 23A41@1762,2AVAB@1,2IMHU@201174,31M1H@2 NA|NA|NA OLIIENHM_00917 1108045.GORHZ_143_00040 1.9e-24 118.6 Actinobacteria Bacteria 2B1PX@1,2GTHR@201174,31U5I@2 NA|NA|NA S Domain of unknown function (DUF202) OLIIENHM_00918 1440774.Y900_000530 1.4e-46 192.2 Mycobacteriaceae yidH ko:K00389 ko00000 Bacteria 23BCV@1762,2GQU9@201174,COG2149@1,COG2149@2 NA|NA|NA S Domain of unknown function (DUF202) OLIIENHM_00919 931627.MycrhDRAFT_3003 1e-61 242.7 Mycobacteriaceae Bacteria 239DI@1762,2IN3Q@201174,COG0607@1,COG0607@2 NA|NA|NA P sulfurtransferase OLIIENHM_00920 246196.MSMEI_0753 2.6e-201 708.0 Mycobacteriaceae metZ GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.48,4.4.1.1,4.4.1.8 ko:K01739,ko:K01758,ko:K01760,ko:K10764 ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017,M00338 R00782,R00999,R01001,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04941,R04944,R04945,R04946,R09366 RC00020,RC00056,RC00069,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000,ko04147 iNJ661.Rv0391 Bacteria 232GW@1762,2GJ5S@201174,COG0626@1,COG0626@2 NA|NA|NA E Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide OLIIENHM_00921 1440774.Y900_015945 8e-22 110.2 Mycobacteriaceae Bacteria 23A4S@1762,2C0TI@1,2IIHH@201174,307V6@2 NA|NA|NA OLIIENHM_00922 1172186.KB911470_gene2957 4.9e-89 334.3 Mycobacteriaceae Bacteria 232PY@1762,2GSDS@201174,COG2852@1,COG2852@2 NA|NA|NA S Protein conserved in bacteria OLIIENHM_00924 931627.MycrhDRAFT_0211 5e-23 113.2 Mycobacteriaceae fadE33 Bacteria 234NN@1762,2GKVN@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_00925 931627.MycrhDRAFT_0212 2.1e-137 495.4 Mycobacteriaceae fadE32 Bacteria 232H1@1762,2GKUW@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_00926 1440774.Y900_010465 1.5e-190 672.2 Mycobacteriaceae fadE31 1.3.8.4 ko:K00253 ko00280,ko01100,map00280,map01100 M00036 R04095 RC00246 ko00000,ko00001,ko00002,ko01000 Bacteria 2362J@1762,2GJA9@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_00927 931627.MycrhDRAFT_0214 1.7e-250 871.7 Mycobacteriaceae fadD3 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0051087 6.2.1.41 ko:K18687 ko00984,ko01100,ko01120,map00984,map01100,map01120 R10769 RC00004,RC00014 ko00000,ko00001,ko01000 Bacteria 232NN@1762,2GIUC@201174,COG0318@1,COG0318@2 NA|NA|NA IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II OLIIENHM_00928 931627.MycrhDRAFT_0215 7.9e-200 703.0 Mycobacteriaceae fadE30 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 Bacteria 233GH@1762,2GM1Q@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_00929 1440774.Y900_010450 6.9e-123 446.8 Mycobacteriaceae Bacteria 235T0@1762,2GN3D@201174,COG1028@1,COG1028@2 NA|NA|NA IQ Dehydrogenase OLIIENHM_00930 1078020.KEK_07657 6.8e-91 340.1 Mycobacteriaceae kstR2 GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0010565,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042802,GO:0042803,GO:0046983,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0062012,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:2000112,GO:2001141 ko:K22108 ko00000,ko03000 Bacteria 234WZ@1762,2HK4X@201174,COG1309@1,COG1309@2 NA|NA|NA K transcriptional OLIIENHM_00931 1078020.KEK_07652 1.1e-185 656.0 Mycobacteriaceae fadA6 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0003988,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005777,GO:0005782,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0031907,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0032787,GO:0034440,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0055114,GO:0070013,GO:0071704,GO:0072329,GO:0097159,GO:1901363,GO:1901575 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2339D@1762,2GJAC@201174,COG0183@1,COG0183@2 NA|NA|NA I Belongs to the thiolase family OLIIENHM_00932 931627.MycrhDRAFT_0222 9.6e-52 209.5 Mycobacteriaceae Bacteria 23AE5@1762,2DMMA@1,2IM8C@201174,32SDH@2 NA|NA|NA OLIIENHM_00933 1299327.I546_6204 5.4e-171 607.1 Mycobacteriaceae fabK GO:0000166,GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0003938,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0007623,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0012505,GO:0016192,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030141,GO:0031410,GO:0031974,GO:0031982,GO:0031983,GO:0032940,GO:0034404,GO:0034641,GO:0034654,GO:0034774,GO:0036094,GO:0036230,GO:0042119,GO:0042278,GO:0042451,GO:0042455,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043299,GO:0043312,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046903,GO:0048511,GO:0050896,GO:0051179,GO:0051234,GO:0055086,GO:0055114,GO:0060205,GO:0070013,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097708,GO:0099503,GO:0101002,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659,GO:1904813 1.13.12.16,1.3.1.9 ko:K00459,ko:K02371 ko00061,ko00910,ko01100,ko01212,map00061,map00910,map01100,map01212 M00083 R00025,R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765 RC00052,RC00076,RC02541,RC02759 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 2340X@1762,2GKA6@201174,COG2070@1,COG2070@2 NA|NA|NA S 2-nitropropane dioxygenase OLIIENHM_00934 350054.Mflv_1488 1.6e-116 425.6 Mycobacteriaceae gctB GO:0008150,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051704 2.8.3.12 ko:K01040 ko00643,ko00650,ko01120,map00643,map00650,map01120 R04000,R05509 RC00012,RC00131,RC00137 ko00000,ko00001,ko01000 Bacteria 232ZB@1762,2GMA1@201174,COG2057@1,COG2057@2 NA|NA|NA I COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit OLIIENHM_00935 318424.EU78_23930 4.5e-139 500.7 Mycobacteriaceae gctA GO:0008150,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051704 2.8.3.12 ko:K01039 ko00643,ko00650,ko01120,map00643,map00650,map01120 R04000,R05509 RC00012,RC00131,RC00137 ko00000,ko00001,ko01000 Bacteria 234C3@1762,2GK61@201174,COG1788@1,COG1788@2 NA|NA|NA I Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit OLIIENHM_00936 710685.MycrhN_2279 5.8e-127 460.3 Mycobacteriaceae echA20 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 Bacteria 232PT@1762,2GN54@201174,COG1024@1,COG1024@2 NA|NA|NA I Enoyl-CoA hydratase OLIIENHM_00937 1341646.CBMO010000128_gene3297 1.4e-101 375.9 Mycobacteriaceae Bacteria 2348R@1762,2GMG3@201174,COG1028@1,COG1028@2 NA|NA|NA IQ Dehydrogenase OLIIENHM_00938 557599.MKAN_11925 1.7e-141 508.8 Mycobacteriaceae Bacteria 2335C@1762,2GJ1F@201174,COG1028@1,COG1028@2 NA|NA|NA IQ Belongs to the short-chain dehydrogenases reductases (SDR) family OLIIENHM_00939 931627.MycrhDRAFT_0230 7.6e-66 257.3 Mycobacteriaceae ddn GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0030312,GO:0031406,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0070967,GO:0071944,GO:0097159,GO:0097367,GO:1901363 Bacteria 239MD@1762,2IIRE@201174,COG0748@1,COG0748@2 NA|NA|NA P F420H(2)-dependent quinone reductase OLIIENHM_00940 1440774.Y900_010375 1.1e-204 719.2 Mycobacteriaceae fadA5 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0003988,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005777,GO:0005782,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0031907,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0032787,GO:0034440,GO:0042579,GO:0042802,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0055114,GO:0070013,GO:0071704,GO:0072329,GO:0097159,GO:1901363,GO:1901575 2.3.1.16,2.3.1.9 ko:K00626,ko:K00632 ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00087,M00088,M00095,M00113,M00373,M00374,M00375 R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 233JC@1762,2GJAC@201174,COG0183@1,COG0183@2 NA|NA|NA I Belongs to the thiolase family OLIIENHM_00941 931627.MycrhDRAFT_0233 2.7e-198 698.0 Mycobacteriaceae 1.14.13.141 ko:K15981 ko00984,ko01120,map00984,map01120 R09859,R11357 RC01216,RC03368 ko00000,ko00001,ko00199,ko01000 Bacteria 232MA@1762,2GKCG@201174,COG2124@1,COG2124@2 NA|NA|NA Q cytochrome p450 OLIIENHM_00942 1298864.AUEQ01000021_gene3553 2.6e-138 498.4 Mycobacteriaceae fadE28 GO:0000166,GO:0003674,GO:0005488,GO:0006066,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0006706,GO:0006707,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0009056,GO:0009062,GO:0009268,GO:0009405,GO:0009628,GO:0009987,GO:0016042,GO:0016054,GO:0016125,GO:0016127,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044110,GO:0044116,GO:0044117,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044403,GO:0044419,GO:0046164,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051704,GO:0055114,GO:0071704,GO:0071949,GO:0072329,GO:0097159,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1901615,GO:1901616,GO:1902652 Bacteria 234IU@1762,2H5SA@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_00943 164757.Mjls_5060 7.9e-200 703.0 Mycobacteriaceae fadE29 GO:0000166,GO:0003674,GO:0005488,GO:0006066,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0006706,GO:0006707,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016125,GO:0016127,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044110,GO:0044116,GO:0044117,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044403,GO:0044419,GO:0046164,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0051704,GO:0055114,GO:0071704,GO:0071949,GO:0072329,GO:0097159,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1901615,GO:1901616,GO:1902652 Bacteria 233ND@1762,2GIXS@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_00944 318424.EU78_23880 3e-152 544.7 Mycobacteriaceae ko:K07068 ko00000 Bacteria 232IZ@1762,2GM2A@201174,COG1545@1,COG1545@2 NA|NA|NA S nucleic-acid-binding protein containing a Zn-ribbon OLIIENHM_00945 1209984.BN978_01745 1.7e-61 241.9 Mycobacteriaceae ko:K07068 ko00000 Bacteria 239K4@1762,2IHT0@201174,COG2030@1,COG2030@2 NA|NA|NA I dehydratase OLIIENHM_00946 710686.Mycsm_05802 2e-203 714.9 Mycobacteriaceae ltp2 Bacteria 236ZY@1762,2GKFR@201174,COG0183@1,COG0183@2 NA|NA|NA I lipid-transfer protein OLIIENHM_00947 931627.MycrhDRAFT_0242 4.4e-131 474.2 Mycobacteriaceae hsd4B Bacteria 234WA@1762,2GJJI@201174,COG2030@1,COG2030@2 NA|NA|NA I dehydratase OLIIENHM_00948 1380386.JIAW01000003_gene855 1.2e-294 1018.5 Mycobacteriaceae kstD GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006066,GO:0006629,GO:0006694,GO:0006706,GO:0006707,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008610,GO:0009056,GO:0009058,GO:0016020,GO:0016042,GO:0016125,GO:0016127,GO:0016229,GO:0016491,GO:0016627,GO:0033765,GO:0044238,GO:0044281,GO:0044282,GO:0044464,GO:0046164,GO:0047571,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576,GO:1901615,GO:1901616,GO:1902652 1.3.99.4 ko:K05898 ko00984,ko01100,ko01120,map00984,map01100,map01120 R09884 RC00991 ko00000,ko00001,ko01000 Bacteria 232MY@1762,2GIXG@201174,COG1053@1,COG1053@2 NA|NA|NA C Succinate dehydrogenase fumarate reductase flavoprotein subunit OLIIENHM_00949 931627.MycrhDRAFT_0244 1.2e-127 462.6 Mycobacteriaceae mhpD 4.2.1.80 ko:K02554 ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220 M00545,M00569 R02601,R04781 RC00750,RC01213 br01602,ko00000,ko00001,ko00002,ko01000 Bacteria 233KJ@1762,2GPBI@201174,COG3971@1,COG3971@2 NA|NA|NA Q hydratase OLIIENHM_00950 710685.MycrhN_2295 6.9e-151 540.0 Mycobacteriaceae mhpF GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0008774,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.10 ko:K04073 ko00360,ko00362,ko00620,ko00621,ko00622,ko00650,ko01100,ko01120,ko01220,map00360,map00362,map00620,map00621,map00622,map00650,map01100,map01120,map01220 M00545,M00569 R00228,R01172 RC00004,RC00184,RC01195 br01602,ko00000,ko00001,ko00002,ko01000 iNJ661.Rv3535c Bacteria 2331S@1762,2GKBZ@201174,COG4569@1,COG4569@2 NA|NA|NA Q Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds OLIIENHM_00951 262316.MAP_0533 4.9e-177 627.1 Mycobacteriaceae hsaF GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 4.1.3.39 ko:K01666 ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220 M00545,M00569 R00750 RC00307,RC00371 br01602,ko00000,ko00001,ko00002,ko01000 Bacteria 234AH@1762,2GJBI@201174,COG0119@1,COG0119@2 NA|NA|NA E Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds OLIIENHM_00952 1370121.AUWS01000051_gene1576 3.4e-187 661.0 Mycobacteriaceae Bacteria 233B0@1762,2HES3@201174,COG5361@1,COG5361@2 NA|NA|NA S Conserved Protein OLIIENHM_00953 710421.Mycch_4594 1.1e-115 422.9 Mycobacteriaceae Bacteria 2345M@1762,2GMAG@201174,COG1028@1,COG1028@2 NA|NA|NA IQ Dehydrogenase OLIIENHM_00954 710421.Mycch_4593 2e-187 661.8 Mycobacteriaceae Bacteria 2329E@1762,2DBBP@1,2I46S@201174,2Z88Z@2 NA|NA|NA S Sulfotransferase domain OLIIENHM_00955 931627.MycrhDRAFT_0252 4.9e-57 227.3 Mycobacteriaceae Bacteria 239B8@1762,28XG2@1,2IFHV@201174,2ZJDK@2 NA|NA|NA OLIIENHM_00956 350054.Mflv_1533 1.2e-205 722.2 Mycobacteriaceae kshA GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0005506,GO:0006066,GO:0006629,GO:0006694,GO:0006706,GO:0006707,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008610,GO:0009056,GO:0009058,GO:0009405,GO:0009987,GO:0010033,GO:0014070,GO:0016042,GO:0016043,GO:0016125,GO:0016127,GO:0016491,GO:0016705,GO:0016709,GO:0022607,GO:0033993,GO:0036200,GO:0036314,GO:0042221,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044238,GO:0044281,GO:0044282,GO:0044419,GO:0046164,GO:0046872,GO:0046914,GO:0047086,GO:0048037,GO:0050292,GO:0050896,GO:0051259,GO:0051260,GO:0051536,GO:0051537,GO:0051540,GO:0051704,GO:0055114,GO:0065003,GO:0070206,GO:0070207,GO:0070723,GO:0071704,GO:0071840,GO:0097305,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576,GO:1901615,GO:1901616,GO:1901700,GO:1902652 1.14.13.142 ko:K15982 ko00984,ko01100,ko01120,map00984,map01100,map01120 R09860 RC02691 ko00000,ko00001,ko01000 Bacteria 2346Z@1762,2GKMV@201174,COG4638@1,COG4638@2 NA|NA|NA P Rieske 2Fe-2S OLIIENHM_00957 1440774.Y900_010270 3.1e-71 274.6 Mycobacteriaceae yrdA GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0008270,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043168,GO:0043169,GO:0043199,GO:0046872,GO:0046914,GO:0050897,GO:0071890,GO:1901681 Bacteria 233UA@1762,2GP22@201174,COG0663@1,COG0663@2 NA|NA|NA S Bacterial transferase hexapeptide (six repeats) OLIIENHM_00958 1380386.JIAW01000003_gene837 6.5e-202 709.9 Mycobacteriaceae ltp3 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 23553@1762,2GJ0W@201174,COG0183@1,COG0183@2 NA|NA|NA I Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation OLIIENHM_00959 710686.Mycsm_05755 2e-173 615.1 Mycobacteriaceae ltp4 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 232DP@1762,2GNCM@201174,COG0183@1,COG0183@2 NA|NA|NA I lipid-transfer protein OLIIENHM_00960 710686.Mycsm_05754 2e-143 515.4 Mycobacteriaceae ko:K07068 ko00000 Bacteria 2342N@1762,2GJHW@201174,COG1545@1,COG1545@2 NA|NA|NA S Nucleic-acid-binding protein containing a Zn-ribbon OLIIENHM_00961 1078020.KEK_14243 1.6e-183 648.7 Mycobacteriaceae mer GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 Bacteria 232GM@1762,2GIY3@201174,COG2141@1,COG2141@2 NA|NA|NA C F420-dependent oxidoreductase OLIIENHM_00962 1440774.Y900_010230 1.7e-112 412.1 Mycobacteriaceae Bacteria 2349M@1762,2GJWN@201174,COG4689@1,COG4689@2 NA|NA|NA Q Acetoacetate decarboxylase OLIIENHM_00963 1440774.Y900_010225 1.3e-194 685.6 Mycobacteriaceae cyp142 GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006066,GO:0006629,GO:0006706,GO:0006707,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008395,GO:0009056,GO:0016042,GO:0016125,GO:0016127,GO:0016491,GO:0016705,GO:0016709,GO:0020037,GO:0030312,GO:0031073,GO:0036199,GO:0044238,GO:0044281,GO:0044282,GO:0044464,GO:0046164,GO:0046906,GO:0048037,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1901615,GO:1901616,GO:1902652 1.14.13.221 ko:K16046 ko00984,ko01120,map00984,map01120 R09859,R11361 RC01216,RC03368 ko00000,ko00001,ko00199,ko01000 Bacteria 233UJ@1762,2GJ8V@201174,COG2124@1,COG2124@2 NA|NA|NA Q cytochrome p450 OLIIENHM_00964 164757.Mjls_5010 8.1e-132 476.5 Mycobacteriaceae echA19 GO:0003674,GO:0003824,GO:0004300,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 Bacteria 2337N@1762,2GKJ6@201174,COG1024@1,COG1024@2 NA|NA|NA I Enoyl-CoA hydratase OLIIENHM_00965 487521.OCU_05580 1.8e-266 924.9 Mycobacteriaceae fadD19 GO:0001676,GO:0003674,GO:0003824,GO:0004467,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009273,GO:0009605,GO:0009607,GO:0009987,GO:0015645,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0019752,GO:0030312,GO:0032787,GO:0042546,GO:0042579,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044085,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051087,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071554,GO:0071704,GO:0071766,GO:0071840,GO:0071944,GO:0075136,GO:1901576 6.2.1.42 ko:K00666,ko:K18688 ko00000,ko01000,ko01004 Bacteria 233WW@1762,2GJA2@201174,COG0318@1,COG0318@2 NA|NA|NA IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II OLIIENHM_00966 1440774.Y900_010205 2.3e-172 611.7 Mycobacteriaceae 1.13.12.16 ko:K00459 ko00910,map00910 R00025 RC02541,RC02759 ko00000,ko00001,ko01000 Bacteria 232ZV@1762,2GKGT@201174,COG2070@1,COG2070@2 NA|NA|NA S 2-nitropropane dioxygenase OLIIENHM_00967 1440774.Y900_010195 8.8e-223 779.6 Mycobacteriaceae ilvX GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016020,GO:0016053,GO:0019752,GO:0030312,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 Bacteria 2361X@1762,2GN3X@201174,COG0028@1,COG0028@2 NA|NA|NA EH Thiamine pyrophosphate enzyme, C-terminal TPP binding domain OLIIENHM_00968 1370121.AUWS01000032_gene492 3.4e-54 218.4 Mycobacteriaceae 3.1.1.74 ko:K08095 ko00000,ko01000 Bacteria 2332I@1762,2A1QU@1,2HZKA@201174,30PZC@2 NA|NA|NA M cutinase OLIIENHM_00969 1440774.Y900_010175 9.9e-227 792.7 Mycobacteriaceae fadD17 GO:0001676,GO:0003674,GO:0003824,GO:0004467,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009273,GO:0009987,GO:0015645,GO:0016020,GO:0016053,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0019752,GO:0032787,GO:0042546,GO:0042759,GO:0043436,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071554,GO:0071704,GO:0071766,GO:0071840,GO:0071944,GO:0072330,GO:1901576 ko:K00666 ko00000,ko01000,ko01004 Bacteria 232CU@1762,2GKZ6@201174,COG0318@1,COG0318@2 NA|NA|NA IQ Activates fatty acids by binding to coenzyme A OLIIENHM_00970 1440774.Y900_010170 1.5e-163 582.4 Mycobacteriaceae fadE27 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 Bacteria 233CJ@1762,2GITF@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_00971 1440774.Y900_010165 5.4e-188 663.7 Mycobacteriaceae fadE26 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 Bacteria 23301@1762,2GIXS@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_00972 931627.MycrhDRAFT_0271 2.5e-23 114.0 Mycobacteriaceae fdxD ko:K05337 ko00000 Bacteria 23BC6@1762,2GRN3@201174,COG1141@1,COG1141@2 NA|NA|NA C Ferredoxin OLIIENHM_00973 931627.MycrhDRAFT_0272 1.9e-132 478.8 Mycobacteriaceae Bacteria 2342W@1762,2GN6U@201174,COG1028@1,COG1028@2 NA|NA|NA IQ Belongs to the short-chain dehydrogenases reductases (SDR) family OLIIENHM_00974 1440774.Y900_010150 1.5e-240 838.6 Mycobacteriaceae otsA GO:0003674,GO:0003824,GO:0003825,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016311,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0016788,GO:0016791,GO:0030145,GO:0030312,GO:0033554,GO:0034637,GO:0035251,GO:0040007,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046527,GO:0046872,GO:0046914,GO:0047260,GO:0050896,GO:0051716,GO:0070413,GO:0071704,GO:0071944,GO:1901576 2.4.1.15,2.4.1.347,3.1.3.12 ko:K00697,ko:K16055 ko00500,ko01100,map00500,map01100 R02737,R02778 RC00005,RC00017,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 GT20 Bacteria 2332Q@1762,2GMX7@201174,COG0380@1,COG0380@2 NA|NA|NA G Probably involved in the osmoprotection via the biosynthesis of trehalose and in the production of glycogen and alpha-glucan via the TreS-Pep2 branch involved in the biosynthesis of maltose-1-phosphate (M1P). Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Probably also able to use ADP-Glc, CDP-Glc, GDP-Glc and TDP-Glc as glucosyl donors OLIIENHM_00975 931627.MycrhDRAFT_0274 2.3e-17 94.0 Mycobacteriaceae Bacteria 23BCE@1762,2FG3C@1,2GRSF@201174,347ZY@2 NA|NA|NA OLIIENHM_00976 931627.MycrhDRAFT_0275 3.7e-14 84.7 Mycobacteriaceae Bacteria 23E81@1762,2BQD2@1,2H8U9@201174,32J8A@2 NA|NA|NA OLIIENHM_00977 1440774.Y900_010130 4.6e-11 74.3 Mycobacteriaceae Bacteria 23BBQ@1762,2AU36@1,2GV9U@201174,31VAF@2 NA|NA|NA OLIIENHM_00978 1078020.KEK_14098 2.7e-122 444.9 Mycobacteriaceae Bacteria 235B5@1762,2GMG3@201174,COG1028@1,COG1028@2 NA|NA|NA IQ Dehydrogenase OLIIENHM_00979 1440774.Y900_010085 1e-68 266.2 Mycobacteriaceae Bacteria 238NG@1762,2IKUM@201174,COG2343@1,COG2343@2 NA|NA|NA S Domain of unknown function (DUF427) OLIIENHM_00980 1440774.Y900_010080 5.7e-207 726.9 Mycobacteriaceae amt_1 ko:K03320 ko00000,ko02000 1.A.11 Bacteria 234YA@1762,2GIZK@201174,COG0004@1,COG0004@2 NA|NA|NA U Ammonium Transporter OLIIENHM_00981 1440774.Y900_020280 3.9e-91 340.9 Mycobacteriaceae fadA4 GO:0003674,GO:0003824,GO:0003988,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044403,GO:0044419,GO:0044464,GO:0046395,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:0075136,GO:1901575 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 232VA@1762,2GJAC@201174,COG0183@1,COG0183@2 NA|NA|NA I Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation OLIIENHM_00982 931627.MycrhDRAFT_6844 2e-107 395.6 Mycobacteriaceae trxA2 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 ko:K03671,ko:K05838 ko04621,ko05418,map04621,map05418 ko00000,ko00001,ko03110 Bacteria 232NJ@1762,2GJ7B@201174,COG3118@1,COG3118@2 NA|NA|NA O Thioredoxin OLIIENHM_00983 487521.OCU_44140 2.3e-181 641.7 Mycobacteriaceae Bacteria 234RM@1762,2HAHI@201174,COG1403@1,COG1403@2 NA|NA|NA V PFAM HNH endonuclease OLIIENHM_00984 1440774.Y900_020295 0.0 1340.5 Mycobacteriaceae glgB GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0040007,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0055114,GO:0071704,GO:0071944,GO:1901576 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 ko00000,ko00001,ko00002,ko01000,ko04147 CBM48,GH13 Bacteria 234A0@1762,2GJ5C@201174,COG0296@1,COG0296@2 NA|NA|NA G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position OLIIENHM_00985 931627.MycrhDRAFT_6842 0.0 1201.8 Mycobacteriaceae glgE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.4.99.16 ko:K16147 ko00500,ko01100,map00500,map01100 R09994 ko00000,ko00001,ko01000 GH13 Bacteria 2332K@1762,2GJKR@201174,COG0366@1,COG0366@2 NA|NA|NA G Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB OLIIENHM_00986 931627.MycrhDRAFT_6841 0.0 1372.8 Mycobacteriaceae glgP GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.4.1.1,2.4.1.8 ko:K00688,ko:K00691 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 R01555,R02111 RC00049 ko00000,ko00001,ko01000 GH65,GT35 Bacteria 23392@1762,2GIVZ@201174,COG0058@1,COG0058@2 NA|NA|NA G phosphorylase OLIIENHM_00987 931627.MycrhDRAFT_6840 6.8e-86 323.9 Mycobacteriaceae Bacteria 232QQ@1762,2A16Y@1,2I9MX@201174,30PD1@2 NA|NA|NA S MspA protein OLIIENHM_00988 931627.MycrhDRAFT_6839 6.3e-199 700.3 Mycobacteriaceae lpqM Bacteria 232SM@1762,2HBKZ@201174,COG2321@1,COG2321@2 NA|NA|NA S neutral zinc metallopeptidase OLIIENHM_00989 931627.MycrhDRAFT_6838 8.2e-290 1002.7 Mycobacteriaceae dinG GO:0003674,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008026,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0042575,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0045004,GO:0045005,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7,3.6.4.12 ko:K02342,ko:K03722 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 235N7@1762,2GKT8@201174,COG1199@1,COG1199@2 NA|NA|NA KL helicase OLIIENHM_00990 1440774.Y900_020330 1.3e-182 646.0 Mycobacteriaceae pncB GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0030312,GO:0034355,GO:0034641,GO:0034654,GO:0043094,GO:0043173,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.21 ko:K00763 ko00760,ko01100,map00760,map01100 R01724 RC00033 ko00000,ko00001,ko01000 Bacteria 232CP@1762,2GJAT@201174,COG1488@1,COG1488@2 NA|NA|NA H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP OLIIENHM_00991 1440774.Y900_020335 5.7e-41 173.3 Mycobacteriaceae clpS GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0050896,GO:0051087 ko:K06891 ko00000 Bacteria 23A0D@1762,2IQ3Z@201174,COG2127@1,COG2127@2 NA|NA|NA S Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation OLIIENHM_00992 931627.MycrhDRAFT_6835 4.7e-73 280.8 Mycobacteriaceae Bacteria 235A4@1762,2E4AX@1,2GW4T@201174,32Z6K@2 NA|NA|NA S Domain of unknown function (DUF2017) OLIIENHM_00993 1209984.BN978_04407 9.7e-128 463.4 Mycobacteriaceae dmpA Bacteria 2353J@1762,2GJKQ@201174,COG3191@1,COG3191@2 NA|NA|NA EQ peptidase S58, DmpA OLIIENHM_00994 1440774.Y900_020350 4.8e-85 320.9 Mycobacteriaceae SEN0012 Bacteria 2358W@1762,2HCGE@201174,COG0705@1,COG0705@2 NA|NA|NA S membrane OLIIENHM_00995 931627.MycrhDRAFT_6829 1.7e-124 452.2 Mycobacteriaceae murI GO:0000270,GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008657,GO:0008881,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0010911,GO:0016020,GO:0016853,GO:0016854,GO:0016855,GO:0030203,GO:0030234,GO:0032780,GO:0034645,GO:0036361,GO:0042030,GO:0042546,GO:0042802,GO:0043086,GO:0043170,GO:0043462,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0047661,GO:0050790,GO:0051336,GO:0051346,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0072586,GO:0098772,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:2000371,GO:2000372 3.6.1.66,5.1.1.3 ko:K01776,ko:K02428 ko00230,ko00471,ko01100,map00230,map00471,map01100 R00260,R00426,R00720,R01855,R02100,R02720,R03531 RC00002,RC00302 ko00000,ko00001,ko01000,ko01011 iYO844.BSU28390 Bacteria 234GH@1762,2GN4I@201174,COG0796@1,COG0796@2 NA|NA|NA M Provides the (R)-glutamate required for cell wall biosynthesis OLIIENHM_00996 1440774.Y900_020360 4.3e-130 470.7 Mycobacteriaceae yhfI GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267 Bacteria 234VF@1762,2GMEX@201174,COG1234@1,COG1234@2 NA|NA|NA S Metal-dependent hydrolases of the beta-lactamase superfamily III OLIIENHM_00997 1440774.Y900_020365 1.5e-130 472.2 Mycobacteriaceae rph GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 ko:K00989 ko00000,ko01000,ko03016 Bacteria 2342B@1762,2I466@201174,COG2123@1,COG2123@2 NA|NA|NA J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates OLIIENHM_00998 262316.MAP_2420c 8.5e-76 290.0 Mycobacteriaceae rdgB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66,5.1.1.3 ko:K01776,ko:K02428 ko00230,ko00471,ko01100,map00230,map00471,map01100 R00260,R00426,R00720,R01855,R02100,R02720,R03531 RC00002,RC00302 ko00000,ko00001,ko01000,ko01011 Bacteria 234MD@1762,2GM2B@201174,COG0127@1,COG0127@2 NA|NA|NA F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions OLIIENHM_00999 931627.MycrhDRAFT_6820 5.6e-45 186.8 Mycobacteriaceae GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 Bacteria 23A2H@1762,2E65S@1,2IMEQ@201174,330UF@2 NA|NA|NA S membrane OLIIENHM_01000 931627.MycrhDRAFT_6819 1.1e-37 162.5 Mycobacteriaceae lprD ko:K02005,ko:K02022 ko00000 Bacteria 23A14@1762,2ISAW@201174,COG1566@1,COG1566@2 NA|NA|NA V Glucitol operon activator OLIIENHM_01001 350054.Mflv_2364 1.3e-80 306.2 Mycobacteriaceae Bacteria 236FR@1762,2HX4P@201174,COG3780@1,COG3780@2 NA|NA|NA L endonuclease activity OLIIENHM_01003 931627.MycrhDRAFT_1719 2.3e-60 238.4 Mycobacteriaceae Bacteria 2396S@1762,2II8B@201174,COG2340@1,COG2340@2 NA|NA|NA S Cysteine-rich secretory protein family OLIIENHM_01004 700508.D174_13815 1.5e-37 161.8 Mycobacteriaceae ko:K02067 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 232I5@1762,2GJVB@201174,COG1463@1,COG1463@2 NA|NA|NA Q Virulence factor Mce family protein OLIIENHM_01005 700508.D174_13820 1.7e-207 728.8 Mycobacteriaceae mce3F ko:K02067 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 232GJ@1762,2GNEP@201174,COG1463@1,COG1463@2 NA|NA|NA Q Virulence factor Mce family protein OLIIENHM_01006 710685.MycrhN_5986 2.3e-39 169.5 Mycobacteriaceae Bacteria 2334C@1762,2GNT2@201174,COG0515@1,COG0515@2 NA|NA|NA KLT serine threonine protein kinase OLIIENHM_01008 285514.JNWO01000015_gene9229 5.2e-19 101.3 Actinobacteria Bacteria 2IEYS@201174,COG1309@1,COG1309@2 NA|NA|NA K Bacterial transcriptional repressor C-terminal OLIIENHM_01009 1448389.BAVQ01000090_gene2088 9.3e-133 480.3 Actinobacteria Bacteria 2GJJB@201174,COG1680@1,COG1680@2 NA|NA|NA V COG1680 Beta-lactamase class C and other penicillin binding proteins OLIIENHM_01011 419947.MRA_0766 1e-29 137.1 Mycobacteriaceae Bacteria 235RJ@1762,2AG2I@1,2GM9W@201174,3166W@2 NA|NA|NA OLIIENHM_01012 1298864.AUEQ01000016_gene3775 3.6e-59 234.2 Mycobacteriaceae hit ko:K02503 ko00000,ko04147 Bacteria 238VC@1762,2IKWU@201174,COG0537@1,COG0537@2 NA|NA|NA FG diadenosine tetraphosphate (Ap4A) hydrolase and other hit family hydrolases OLIIENHM_01013 931627.MycrhDRAFT_0297 3.9e-94 351.3 Mycobacteriaceae Bacteria 232C6@1762,2GM3R@201174,COG1028@1,COG1028@2 NA|NA|NA IQ short-chain OLIIENHM_01014 1380386.JIAW01000003_gene774 2e-60 238.4 Mycobacteriaceae 5.3.3.1 ko:K01822 ko00140,ko00984,ko01100,ko01120,map00140,map00984,map01100,map01120 M00107,M00110 R01837,R02216,R02499,R02840,R03327,R04163,R04678,R04849,R09955 RC00146,RC00762 ko00000,ko00001,ko00002,ko01000 Bacteria 238N9@1762,2IG5P@201174,COG3631@1,COG3631@2 NA|NA|NA S nuclear transport factor 2 OLIIENHM_01015 246196.MSMEI_5707 1.2e-181 642.5 Mycobacteriaceae adhB GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.1.1.1,1.1.1.284 ko:K00001,ko:K00121 ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204 R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273 ko00000,ko00001,ko01000 Bacteria 233X9@1762,2GM8C@201174,COG1062@1,COG1062@2 NA|NA|NA C alcohol dehydrogenase OLIIENHM_01016 1380386.JIAW01000003_gene771 2.9e-83 314.7 Mycobacteriaceae Bacteria 232M0@1762,28NTV@1,2GS03@201174,2ZBSB@2 NA|NA|NA OLIIENHM_01017 1150599.MPHLEI_17220 2.3e-25 120.9 Mycobacteriaceae cyp51 1.14.13.70 ko:K05337,ko:K05917 ko00100,ko01100,ko01110,ko01130,map00100,map01100,map01110,map01130 M00101 R05640,R05731 RC01442 ko00000,ko00001,ko00002,ko00199,ko01000 Bacteria 23AMF@1762,2GS47@201174,COG1141@1,COG1141@2 NA|NA|NA C ferredoxin OLIIENHM_01018 710421.Mycch_4522 9.5e-221 772.7 Mycobacteriaceae cyp51 GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0008150,GO:0008152,GO:0008202,GO:0008398,GO:0016125,GO:0016491,GO:0016705,GO:0016709,GO:0020037,GO:0032451,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046906,GO:0048037,GO:0055114,GO:0070988,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901615 1.14.13.70 ko:K05917 ko00100,ko01100,ko01110,ko01130,map00100,map01100,map01110,map01130 M00101 R05640,R05731 RC01442 ko00000,ko00001,ko00002,ko00199,ko01000 Bacteria 232PI@1762,2GK4Z@201174,COG2124@1,COG2124@2 NA|NA|NA Q cytochrome p450 OLIIENHM_01019 1078020.KEK_13998 7.6e-125 453.4 Mycobacteriaceae MA20_43565 Bacteria 2352S@1762,2I8VU@201174,COG4221@1,COG4221@2 NA|NA|NA S Dehydrogenase OLIIENHM_01020 246196.MSMEI_5702 7.8e-174 616.7 Mycobacteriaceae cyp123A3 GO:0003674,GO:0003824,GO:0004497,GO:0005575,GO:0005623,GO:0005886,GO:0006066,GO:0006629,GO:0006706,GO:0006707,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008395,GO:0009056,GO:0016020,GO:0016042,GO:0016125,GO:0016127,GO:0016491,GO:0016705,GO:0016709,GO:0036199,GO:0044238,GO:0044281,GO:0044282,GO:0044464,GO:0046164,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616,GO:1902652 Bacteria 233DK@1762,2GJ8V@201174,COG2124@1,COG2124@2 NA|NA|NA C cytochrome p450 OLIIENHM_01021 931627.MycrhDRAFT_0306 3e-70 271.6 Mycobacteriaceae GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141 ko:K22107 ko00000,ko03000 Bacteria 2355F@1762,2GK2V@201174,COG1309@1,COG1309@2 NA|NA|NA K Transcriptional regulator OLIIENHM_01022 1440774.Y900_020110 1.6e-127 462.2 Mycobacteriaceae thrC GO:0003674,GO:0003824,GO:0004795,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 iLJ478.TM0546,iSB619.SA_RS06615,iYO844.BSU32250 Bacteria 232U9@1762,2GJ5F@201174,COG0498@1,COG0498@2 NA|NA|NA E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine OLIIENHM_01023 931627.MycrhDRAFT_6005 1.1e-114 419.9 Mycobacteriaceae thrB GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.1.39 ko:K00872 ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 M00018 R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 iECSE_1348.ECSE_0003,iJN678.thrB,iLJ478.TM0545,iSB619.SA_RS06620 Bacteria 233R1@1762,2GKIW@201174,COG0083@1,COG0083@2 NA|NA|NA E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate OLIIENHM_01024 931627.MycrhDRAFT_6006 1.4e-224 785.8 Mycobacteriaceae rho GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006360,GO:0006363,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 ko:K03628 ko03018,map03018 ko00000,ko00001,ko03019,ko03021 Bacteria 2333A@1762,2GIWY@201174,COG1158@1,COG1158@2 NA|NA|NA K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template OLIIENHM_01025 164757.Mjls_3875 2.2e-57 228.8 Mycobacteriaceae Bacteria 237EJ@1762,2AEJC@1,2GMTI@201174,314EV@2 NA|NA|NA S Mycothiol maleylpyruvate isomerase N-terminal domain OLIIENHM_01026 1265502.KB905962_gene373 3.8e-09 67.0 Comamonadaceae metX GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 R01776 RC00004,RC00041 ko00000,ko00001,ko01000 Bacteria 1MVJV@1224,2VHU9@28216,4AAW1@80864,COG2021@1,COG2021@2 NA|NA|NA E Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine OLIIENHM_01029 710111.FraQA3DRAFT_0164 1.2e-26 127.9 Actinobacteria Bacteria 2GKI5@201174,COG1835@1,COG1835@2 NA|NA|NA I Acyltransferase OLIIENHM_01030 931627.MycrhDRAFT_4265 9.8e-52 209.5 Mycobacteriaceae zur GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010043,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0046872,GO:0046914,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 ko:K02076,ko:K03711,ko:K09823 ko02024,map02024 ko00000,ko00001,ko03000 Bacteria 239H4@1762,2IKS3@201174,COG0735@1,COG0735@2 NA|NA|NA P Belongs to the Fur family OLIIENHM_01031 931627.MycrhDRAFT_4266 4.4e-35 154.1 Mycobacteriaceae Bacteria 239HP@1762,2CA90@1,2IJI6@201174,336GT@2 NA|NA|NA OLIIENHM_01032 931627.MycrhDRAFT_4267 2.5e-148 531.6 Mycobacteriaceae uppS GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008834,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0050347,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617 2.5.1.31,2.5.1.86,2.5.1.88 ko:K00806,ko:K14215,ko:K21273 ko00900,ko01110,map00900,map01110 R06447,R09244,R09731 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 Bacteria 233W9@1762,2GIXF@201174,COG0020@1,COG0020@2 NA|NA|NA H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids OLIIENHM_01033 931627.MycrhDRAFT_4268 1.3e-135 489.2 Mycobacteriaceae recO GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 ko:K03584 ko03440,map03440 ko00000,ko00001,ko03400 Bacteria 233NJ@1762,2GK81@201174,COG1381@1,COG1381@2 NA|NA|NA L Involved in DNA repair and RecF pathway recombination OLIIENHM_01034 1380386.JIAW01000002_gene6021 9.1e-143 513.1 Mycobacteriaceae era GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043021,GO:0043024,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070181,GO:0070925,GO:0071826,GO:0071840,GO:0097159,GO:1901363 ko:K03595 ko00000,ko03009,ko03029 Bacteria 234C1@1762,2GJJE@201174,COG1159@1,COG1159@2 NA|NA|NA S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism OLIIENHM_01035 931627.MycrhDRAFT_4275 7.2e-186 656.8 Mycobacteriaceae corC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 235HK@1762,2GIWR@201174,COG1253@1,COG1253@2 NA|NA|NA S CBS domain OLIIENHM_01036 1150599.MPHLEI_22629 7.8e-86 323.2 Mycobacteriaceae ybeY GO:0000469,GO:0000478,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006355,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016072,GO:0016151,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0019219,GO:0019222,GO:0019538,GO:0022613,GO:0030490,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043244,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141 2.6.99.2,3.5.4.5 ko:K01489,ko:K03474,ko:K03595,ko:K07042 ko00240,ko00750,ko00983,ko01100,map00240,map00750,map00983,map01100 M00124 R01878,R02485,R05838,R08221 RC00074,RC00514,RC01476 ko00000,ko00001,ko00002,ko01000,ko03009,ko03029 Bacteria 233SU@1762,2GMUF@201174,COG0319@1,COG0319@2 NA|NA|NA J Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA OLIIENHM_01037 1440774.Y900_022380 2.2e-158 565.1 Mycobacteriaceae phoH GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K06217 ko00000 Bacteria 234YD@1762,2GK0W@201174,COG1702@1,COG1702@2 NA|NA|NA T Phosphate starvation-inducible protein PhoH OLIIENHM_01038 931627.MycrhDRAFT_4281 3e-88 331.6 Mycobacteriaceae rsmE GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070042,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.193 ko:K09761 ko00000,ko01000,ko03009 Bacteria 233VW@1762,2GTKX@201174,COG1385@1,COG1385@2 NA|NA|NA J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit OLIIENHM_01039 931627.MycrhDRAFT_4282 3.6e-157 561.2 Mycobacteriaceae dnaJ GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944 ko:K03686 ko00000,ko03029,ko03110 Bacteria 235XE@1762,2GK69@201174,COG0484@1,COG0484@2 NA|NA|NA O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins OLIIENHM_01040 1440774.Y900_022365 8.1e-164 583.2 Mycobacteriaceae hrcA GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 ko:K03705 ko00000,ko03000 Bacteria 234A9@1762,2GKF5@201174,COG1420@1,COG1420@2 NA|NA|NA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons OLIIENHM_01041 419947.MRA_2398 7.6e-49 199.5 Mycobacteriaceae Bacteria 23A0C@1762,2IKJX@201174,32SQA@2,COG5450@1 NA|NA|NA K Transcription regulator of the Arc MetJ class OLIIENHM_01043 1440774.Y900_022355 4.8e-156 557.8 Mycobacteriaceae Bacteria 233BM@1762,2GIV9@201174,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor OLIIENHM_01044 1440774.Y900_022350 3.5e-119 434.5 Mycobacteriaceae Bacteria 235AN@1762,2GIZB@201174,COG0745@1,COG0745@2 NA|NA|NA KT transcriptional OLIIENHM_01045 258533.BN977_04429 1.4e-178 632.9 Mycobacteriaceae can GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008270,GO:0015976,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914 4.2.1.1 ko:K01673,ko:K03321 ko00910,map00910 R00132,R10092 RC02807 ko00000,ko00001,ko01000,ko02000 2.A.53.3 iAF987.Gmet_3517,iNJ661.Rv3273,iSBO_1134.SBO_0115,iSbBS512_1146.SbBS512_E0119 Bacteria 234TY@1762,2GJCB@201174,COG0288@1,COG0288@2,COG0659@1,COG0659@2 NA|NA|NA P Transporter OLIIENHM_01047 931627.MycrhDRAFT_4285 4.2e-169 600.9 Mycobacteriaceae hemN GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 iNJ661.Rv2388c Bacteria 233HD@1762,2GJXX@201174,COG0635@1,COG0635@2 NA|NA|NA H Involved in the biosynthesis of porphyrin-containing compound OLIIENHM_01048 931627.MycrhDRAFT_4286 9.1e-282 975.7 Mycobacteriaceae sir GO:0000096,GO:0000097,GO:0000103,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016002,GO:0016053,GO:0016491,GO:0016667,GO:0016673,GO:0019344,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050311,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.7.7.1,1.8.7.1 ko:K00366,ko:K00392 ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120 M00176,M00531 R00790,R00859,R03600 RC00065,RC00176 ko00000,ko00001,ko00002,ko01000 Bacteria 233I7@1762,2GJRN@201174,COG0155@1,COG0155@2 NA|NA|NA C Belongs to the nitrite and sulfite reductase 4Fe-4S domain family OLIIENHM_01049 1440774.Y900_022325 3.9e-101 374.4 Mycobacteriaceae cysH GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004604,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016667,GO:0016671,GO:0019344,GO:0019752,GO:0040007,GO:0043436,GO:0043866,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.8.4.10,1.8.4.8 ko:K00390 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R02021 RC00007,RC02862 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv2392 Bacteria 2345B@1762,2GJ3Z@201174,COG0175@1,COG0175@2 NA|NA|NA EH Belongs to the PAPS reductase family. CysH subfamily OLIIENHM_01050 1440774.Y900_022320 9.7e-76 290.0 Mycobacteriaceae cbiX 4.99.1.3 ko:K03795 ko00860,ko01100,ko01120,map00860,map01100,map01120 R05807 RC01012 ko00000,ko00001,ko01000 Bacteria 235WA@1762,2GS51@201174,COG2138@1,COG2138@2 NA|NA|NA S CbiX OLIIENHM_01051 1380386.JIAW01000002_gene5594 1.3e-80 306.6 Mycobacteriaceae bla 3.5.2.6 ko:K01467,ko:K17836,ko:K18767,ko:K18768 ko00311,ko01130,ko01501,ko02020,map00311,map01130,map01501,map02020 M00627,M00628 R06363 RC01499 br01600,ko00000,ko00001,ko00002,ko01000,ko01504 Bacteria 2343X@1762,2GN1D@201174,COG2367@1,COG2367@2 NA|NA|NA V beta-lactamase OLIIENHM_01053 1440774.Y900_022315 7.2e-173 613.2 Mycobacteriaceae cysA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008144,GO:0008150,GO:0008272,GO:0008509,GO:0015075,GO:0015103,GO:0015116,GO:0015318,GO:0015399,GO:0015405,GO:0015419,GO:0015698,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043225,GO:0043492,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0072348,GO:0097159,GO:0097367,GO:0098656,GO:0098660,GO:0098661,GO:0099133,GO:1901265,GO:1901363,GO:1901682,GO:1902358 3.6.3.25,3.6.3.29 ko:K02017,ko:K02045,ko:K10112,ko:K16787 ko00920,ko02010,map00920,map02010 M00185,M00189,M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00582,M00602,M00605,M00606 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.1,3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35,3.A.1.6.1,3.A.1.6.3,3.A.1.8 iE2348C_1286.E2348C_2607,iSSON_1240.SSON_2511 Bacteria 233B6@1762,2I3KJ@201174,COG1118@1,COG1118@2 NA|NA|NA P Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system OLIIENHM_01054 931627.MycrhDRAFT_4290 1.6e-119 435.6 Mycobacteriaceae cysW GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02046,ko:K02047 ko00920,ko02010,map00920,map02010 M00185 ko00000,ko00001,ko00002,ko02000 3.A.1.6.1,3.A.1.6.3 iPC815.YPO3013 Bacteria 232KG@1762,2GMTK@201174,COG4208@1,COG4208@2 NA|NA|NA P sulfate ABC transporter OLIIENHM_01055 1209984.BN978_07535 2e-112 412.1 Mycobacteriaceae cysT GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008272,GO:0015698,GO:0016020,GO:0044464,GO:0051179,GO:0051234,GO:0071944,GO:0072348 ko:K02018,ko:K02046 ko00920,ko02010,map00920,map02010 M00185,M00189 ko00000,ko00001,ko00002,ko02000 3.A.1.6.1,3.A.1.6.3,3.A.1.8 iAPECO1_1312.APECO1_4122,iE2348C_1286.E2348C_2609,iECNA114_1301.ECNA114_2500,iECOK1_1307.ECOK1_2740,iECP_1309.ECP_2447,iECS88_1305.ECS88_2613,iECSF_1327.ECSF_2287,iJN746.PP_5170,iLF82_1304.LF82_0425,iNRG857_1313.NRG857_12150,iSDY_1059.SDY_2620,iUMN146_1321.UM146_04505,iUTI89_1310.UTI89_C2757,iYL1228.KPN_02772 Bacteria 2361N@1762,2GP6P@201174,COG0555@1,COG0555@2 NA|NA|NA O sulfate ABC transporter OLIIENHM_01056 1440774.Y900_022300 1.2e-159 569.3 Mycobacteriaceae sbpA GO:0005575,GO:0005623,GO:0042597,GO:0044464 ko:K02048 ko00920,ko02010,map00920,map02010 M00185 ko00000,ko00001,ko00002,ko02000 3.A.1.6.1,3.A.1.6.3 iJN678.sbpA Bacteria 234I9@1762,2GJIK@201174,COG1613@1,COG1613@2 NA|NA|NA P sulfate ABC transporter OLIIENHM_01057 1172186.KB911468_gene916 3.4e-12 77.0 Mycobacteriaceae Bacteria 23B94@1762,2AUGB@1,2GQVX@201174,31K4H@2 NA|NA|NA OLIIENHM_01058 1440774.Y900_022280 0.0 1243.0 Mycobacteriaceae GO:0003674,GO:0003824,GO:0004553,GO:0004555,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005993,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0015927,GO:0016020,GO:0016052,GO:0016787,GO:0016798,GO:0042301,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044464,GO:0046352,GO:0071704,GO:0071944,GO:1901575 Bacteria 232Y7@1762,2GJAD@201174,COG3387@1,COG3387@2 NA|NA|NA G hydrolase OLIIENHM_01059 931627.MycrhDRAFT_4299 2e-49 202.6 Mycobacteriaceae lppR_1 Bacteria 238E0@1762,2AEV2@1,2IC11@201174,31E9X@2 NA|NA|NA S PknH-like extracellular domain OLIIENHM_01060 1440774.Y900_022255 2.9e-296 1023.8 Mycobacteriaceae lepA GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 ko:K03596 ko05134,map05134 ko00000,ko00001 Bacteria 232JQ@1762,2GJAB@201174,COG0481@1,COG0481@2 NA|NA|NA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner OLIIENHM_01063 931627.MycrhDRAFT_4401 6.3e-106 390.2 Mycobacteriaceae clpP GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 ko00000,ko00001,ko01000,ko01002 Bacteria 235S2@1762,2GKNK@201174,COG0740@1,COG0740@2 NA|NA|NA O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins OLIIENHM_01064 1440774.Y900_021825 2.1e-100 371.7 Mycobacteriaceae clpP GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 ko00000,ko00001,ko01000,ko01002 Bacteria 234GC@1762,2GK5C@201174,COG0740@1,COG0740@2 NA|NA|NA OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins OLIIENHM_01065 931627.MycrhDRAFT_4403 4e-203 714.1 Mycobacteriaceae tig GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944 ko:K03545 ko00000 Bacteria 232VK@1762,2GJIG@201174,COG0544@1,COG0544@2 NA|NA|NA D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase OLIIENHM_01068 931627.MycrhDRAFT_0396 9.9e-38 163.3 Mycobacteriaceae Bacteria 237QU@1762,2I9VU@201174,COG2203@1,COG2203@2 NA|NA|NA T PFAM GAF domain OLIIENHM_01069 1440774.Y900_009465 4.1e-169 601.3 Mycobacteriaceae wcaJ ko:K03606,ko:K20997 ko02025,ko05111,map02025,map05111 ko00000,ko00001 Bacteria 2330E@1762,2GK0M@201174,COG1086@1,COG1086@2,COG2148@1,COG2148@2 NA|NA|NA GM sugar transferase OLIIENHM_01070 1440774.Y900_021760 7.8e-195 686.4 Mycobacteriaceae estC Bacteria 232ZY@1762,2GJJB@201174,COG1680@1,COG1680@2 NA|NA|NA V beta-lactamase OLIIENHM_01071 258533.BN977_00762 3.3e-91 341.7 Mycobacteriaceae Bacteria 23346@1762,28PSZ@1,2GMRM@201174,2ZCEC@2 NA|NA|NA OLIIENHM_01072 931627.MycrhDRAFT_4417 1.5e-125 455.7 Mycobacteriaceae nei1 GO:0000702,GO:0000703,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0003906,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006289,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0008152,GO:0008534,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034599,GO:0034641,GO:0042221,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0070887,GO:0071704,GO:0090304,GO:0097159,GO:0097506,GO:0140097,GO:1901360,GO:1901363 3.2.2.23,4.2.99.18 ko:K05522,ko:K10563 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 2344N@1762,2GKUI@201174,COG0266@1,COG0266@2 NA|NA|NA L Belongs to the FPG family OLIIENHM_01073 318424.EU78_18250 5.3e-78 297.0 Mycobacteriaceae rpiB GO:0003674,GO:0003824,GO:0004751,GO:0005575,GO:0005576,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 5.3.1.6 ko:K01808 ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv2465c Bacteria 233S0@1762,2GKJG@201174,COG0698@1,COG0698@2 NA|NA|NA G Ribose 5-phosphate isomerase OLIIENHM_01074 557599.MKAN_05475 5.7e-93 347.1 Mycobacteriaceae yjbH GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 Bacteria 235YY@1762,2GJNX@201174,COG2761@1,COG2761@2 NA|NA|NA Q DSBA-like thioredoxin domain OLIIENHM_01075 1440774.Y900_021705 0.0 1406.3 Mycobacteriaceae pepN 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 Bacteria 2339W@1762,2GJJ4@201174,COG0308@1,COG0308@2 NA|NA|NA E aminopeptidase N OLIIENHM_01076 1440774.Y900_021695 5.6e-51 207.2 Mycobacteriaceae GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 238JZ@1762,2IRMT@201174,COG1512@1,COG1512@2 NA|NA|NA S Domain of unknown function (DUF5130) OLIIENHM_01077 931627.MycrhDRAFT_4428 2.5e-96 358.2 Mycobacteriaceae Bacteria 234ZS@1762,2GN1W@201174,COG1403@1,COG1403@2 NA|NA|NA L endonuclease OLIIENHM_01078 350058.Mvan_4066 4.1e-58 230.7 Mycobacteriaceae glbO GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008144,GO:0008150,GO:0015669,GO:0015671,GO:0015893,GO:0016020,GO:0019825,GO:0020037,GO:0036094,GO:0042221,GO:0042493,GO:0044464,GO:0046906,GO:0048037,GO:0050896,GO:0051179,GO:0051234,GO:0071944,GO:0097159,GO:1901363 ko:K06886 ko00000 Bacteria 2399D@1762,2IKPF@201174,COG2346@1,COG2346@2 NA|NA|NA S truncated OLIIENHM_01079 931627.MycrhDRAFT_4432 1.4e-76 292.7 Mycobacteriaceae Bacteria 233ZX@1762,2DQ1M@1,2GJD1@201174,32UNB@2 NA|NA|NA OLIIENHM_01080 931627.MycrhDRAFT_4433 6.8e-61 240.0 Mycobacteriaceae ko:K07107 ko00000,ko01000 Bacteria 239E1@1762,2IFAK@201174,COG0824@1,COG0824@2 NA|NA|NA S thioesterase OLIIENHM_01081 931627.MycrhDRAFT_4434 0.0 1680.2 Mycobacteriaceae gdhB GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016638,GO:0016639,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 R00243 RC00006,RC02799 ko00000,ko00001,ko01000 Bacteria 234YS@1762,2GK0C@201174,COG2902@1,COG2902@2 NA|NA|NA E Dehydrogenase OLIIENHM_01082 1385518.N798_16970 4.7e-21 107.8 Intrasporangiaceae Bacteria 2GS2W@201174,4FGK2@85021,COG3832@1,COG3832@2 NA|NA|NA S Protein of unknown function (DUF2505) OLIIENHM_01083 1380370.JIBA01000014_gene2099 6.5e-18 97.4 Intrasporangiaceae Bacteria 2GS2W@201174,4FGK2@85021,COG3832@1,COG3832@2 NA|NA|NA S Protein of unknown function (DUF2505) OLIIENHM_01085 479433.Caci_7582 6.8e-75 287.7 Actinobacteria ko:K07001 ko00000 Bacteria 2IB0F@201174,COG1752@1,COG1752@2 NA|NA|NA S esterase of the alpha-beta hydrolase superfamily OLIIENHM_01086 1120950.KB892764_gene5614 3.8e-156 558.1 Propionibacteriales tgs3 GO:0000302,GO:0001666,GO:0003674,GO:0003824,GO:0004144,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0006638,GO:0006639,GO:0006641,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019432,GO:0030312,GO:0036293,GO:0040007,GO:0042221,GO:0042493,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0044464,GO:0045017,GO:0046460,GO:0046463,GO:0046486,GO:0047196,GO:0050896,GO:0051704,GO:0070482,GO:0071704,GO:0071731,GO:0071944,GO:0097366,GO:1901576,GO:1901698,GO:1901700 2.3.1.20 ko:K00635 ko00561,ko01100,map00561,map01100 M00089 R02251 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 Bacteria 2HEFF@201174,4DN7F@85009,COG1020@1,COG1020@2 NA|NA|NA Q Belongs to the long-chain O-acyltransferase family OLIIENHM_01090 419947.MRA_1321 8.5e-135 486.9 Mycobacteriaceae ko:K07485 ko00000 Bacteria 23814@1762,2GJK7@201174,COG3464@1,COG3464@2 NA|NA|NA L Transposase OLIIENHM_01091 298655.KI912266_gene787 4.8e-147 527.7 Frankiales Bacteria 2GNQB@201174,4ETFP@85013,COG3547@1,COG3547@2 NA|NA|NA L transposase IS116 IS110 IS902 family protein OLIIENHM_01092 365528.KB891230_gene1835 4.8e-34 151.4 Actinobacteria Bacteria 2DMWY@1,2ISFN@201174,32U6G@2 NA|NA|NA OLIIENHM_01093 35754.JNYJ01000033_gene2610 9.2e-29 132.9 Micromonosporales Bacteria 2IQI4@201174,4DFMR@85008,COG1917@1,COG1917@2 NA|NA|NA S conserved protein, contains double-stranded beta-helix domain OLIIENHM_01094 33876.JNXY01000009_gene8951 3.5e-22 110.9 Micromonosporales hcaC ko:K05710 ko00360,ko01120,ko01220,map00360,map01120,map01220 M00545 R06782,R06783 RC00098 br01602,ko00000,ko00001,ko00002 Bacteria 2IQK7@201174,4DEJP@85008,COG2146@1,COG2146@2 NA|NA|NA P Rieske-like [2Fe-2S] domain OLIIENHM_01095 1385519.N801_18595 4.1e-37 161.0 Intrasporangiaceae Bacteria 2IK6G@201174,4FH99@85021,COG3945@1,COG3945@2 NA|NA|NA S Hemerythrin HHE cation binding domain OLIIENHM_01096 1184609.KILIM_125_00030 6.3e-21 106.7 Dermatophilaceae Bacteria 2GS7C@201174,4F77B@85018,COG4309@1,COG4309@2 NA|NA|NA S Uncharacterized conserved protein (DUF2249) OLIIENHM_01097 479431.Namu_3634 5.7e-52 211.1 Frankiales Bacteria 2IAWJ@201174,4ESV7@85013,COG2345@1,COG2345@2 NA|NA|NA K IclR helix-turn-helix domain OLIIENHM_01098 1304865.JAGF01000001_gene2511 1.2e-83 317.0 Cellulomonadaceae 1.7.2.1 ko:K00368 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 Bacteria 2HG56@201174,4F1NM@85016,COG4243@1,COG4243@2 NA|NA|NA S Vitamin k epoxide reductase OLIIENHM_01099 1463926.JOCA01000013_gene1592 5.3e-236 824.3 Actinobacteria nirK 1.7.2.1 ko:K00368 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 Bacteria 2GPUP@201174,COG2132@1,COG2132@2 NA|NA|NA Q Multicopper oxidase OLIIENHM_01101 164757.Mjls_1148 3.8e-83 314.3 Mycobacteriaceae Bacteria 234MY@1762,2GNZF@201174,COG5516@1,COG5516@2 NA|NA|NA S Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding OLIIENHM_01102 1440774.Y900_007625 3e-45 189.1 Mycobacteriaceae Bacteria 236A4@1762,2GMTE@201174,COG0443@1,COG0443@2 NA|NA|NA O Type VII secretion-associated protein, Rv3446c family, C-terminal domain OLIIENHM_01103 1440774.Y900_007585 2.4e-72 278.1 Mycobacteriaceae rplM GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0070180,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 ko:K02871 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 238TI@1762,2IFG1@201174,COG0102@1,COG0102@2 NA|NA|NA J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly OLIIENHM_01104 350058.Mvan_1470 9.1e-68 263.1 Mycobacteriaceae rpsI GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02996 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 238NY@1762,2GNDY@201174,COG0103@1,COG0103@2 NA|NA|NA J Belongs to the universal ribosomal protein uS9 family OLIIENHM_01105 710686.Mycsm_01093 1.6e-23 115.9 Mycobacteriaceae Bacteria 23BRS@1762,2B22A@1,2GU2P@201174,31UJ5@2 NA|NA|NA OLIIENHM_01106 931627.MycrhDRAFT_0780 7.9e-199 699.9 Mycobacteriaceae glmM GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006464,GO:0006468,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008966,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019538,GO:0034641,GO:0034654,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046777,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 R02060 RC00408 ko00000,ko00001,ko01000 iAF987.Gmet_1886,iLJ478.TM0184,iSB619.SA_RS11275,iSBO_1134.SBO_3206 Bacteria 232IQ@1762,2GN87@201174,COG1109@1,COG1109@2 NA|NA|NA G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate OLIIENHM_01107 931627.MycrhDRAFT_0781 5.1e-08 63.5 Mycobacteriaceae Bacteria 23BBJ@1762,2BI3A@1,2GR4H@201174,32C8E@2 NA|NA|NA OLIIENHM_01109 1440774.Y900_007555 2.1e-167 595.1 Mycobacteriaceae Bacteria 23592@1762,2GIY3@201174,COG2141@1,COG2141@2 NA|NA|NA C F420-dependent oxidoreductase OLIIENHM_01110 1440774.Y900_007550 7.6e-99 367.1 Mycobacteriaceae 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 Bacteria 2349U@1762,2GKWS@201174,COG0412@1,COG0412@2 NA|NA|NA Q Dienelactone hydrolase OLIIENHM_01111 931627.MycrhDRAFT_0785 0.0 1114.4 Mycobacteriaceae glmS GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016020,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 iNJ661.Rv3436c,iSB619.SA_RS11245,iYO844.BSU01780 Bacteria 234Q7@1762,2GKH0@201174,COG0449@1,COG0449@2 NA|NA|NA M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source OLIIENHM_01112 1150599.MPHLEI_09309 1.7e-196 692.2 Mycobacteriaceae nnrD GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0052855,GO:0052856,GO:0052857 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 ko00000,ko01000 Bacteria 233M2@1762,2GJHB@201174,COG0062@1,COG0062@2,COG0063@1,COG0063@2 NA|NA|NA G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration OLIIENHM_01113 1440774.Y900_007525 2.5e-245 854.4 Mycobacteriaceae gadB 4.1.1.15 ko:K01580 ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940 M00027 R00261,R00489,R01682,R02466 RC00299 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv3432c Bacteria 236S2@1762,2GKIH@201174,COG0076@1,COG0076@2 NA|NA|NA E Belongs to the group II decarboxylase family OLIIENHM_01114 931627.MycrhDRAFT_0793 1.4e-164 585.9 Mycobacteriaceae alr GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0006022,GO:0006023,GO:0006024,GO:0006082,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008784,GO:0009058,GO:0009059,GO:0009078,GO:0009079,GO:0009252,GO:0009273,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0019842,GO:0030170,GO:0030203,GO:0030632,GO:0034645,GO:0036094,GO:0036361,GO:0040007,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044281,GO:0044283,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0047661,GO:0048037,GO:0050662,GO:0070279,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 R00401 RC00285 ko00000,ko00001,ko01000,ko01011 iEC55989_1330.EC55989_1285,iECIAI39_1322.ECIAI39_1880,iECO103_1326.ECO103_1292,iECO26_1355.ECO26_1703,iECSE_1348.ECSE_1238,iECUMN_1333.ECUMN_1479,iECW_1372.ECW_m1275,iEKO11_1354.EKO11_2666,iEcE24377_1341.EcE24377A_1335,iPC815.YPO0321,iSBO_1134.SBO_4064,iSbBS512_1146.SbBS512_E4542,iWFL_1372.ECW_m1275,iYL1228.KPN_02308,iYL1228.KPN_04440 Bacteria 234FJ@1762,2GM2Y@201174,COG0787@1,COG0787@2 NA|NA|NA E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids OLIIENHM_01115 1440774.Y900_007485 3.7e-159 567.8 Mycobacteriaceae Bacteria 23694@1762,2GMCK@201174,COG2267@1,COG2267@2 NA|NA|NA I Alpha beta hydrolase OLIIENHM_01116 710687.KI912270_gene2734 4e-57 227.6 Mycobacteriaceae ydiB GO:0002949,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.7.1.221,5.1.1.1 ko:K01775,ko:K06925,ko:K07102 ko00473,ko00520,ko01100,ko01502,map00473,map00520,map01100,map01502 R00401,R08968,R11024 RC00002,RC00078,RC00285 ko00000,ko00001,ko01000,ko01011,ko03016 Bacteria 238N0@1762,2IKV2@201174,COG0802@1,COG0802@2 NA|NA|NA S tRNA threonylcarbamoyladenosine modification OLIIENHM_01117 262316.MAP_4261 8.2e-74 283.5 Mycobacteriaceae yeaZ GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0071944,GO:0090304,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 ko:K01409,ko:K14742 R10648 RC00070,RC00416 ko00000,ko01000,ko03016 Bacteria 233E2@1762,2GMTM@201174,COG1214@1,COG1214@2 NA|NA|NA O Peptidase M22, glycoprotease OLIIENHM_01118 1440774.Y900_007470 4.2e-64 250.8 Mycobacteriaceae rimI GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008999,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0017189,GO:0018193,GO:0018194,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564 2.3.1.128,2.3.1.234 ko:K01409,ko:K03789,ko:K14742 R10648 RC00070,RC00416 ko00000,ko01000,ko03009,ko03016 Bacteria 238NF@1762,2IM9R@201174,COG0454@1,COG0456@2 NA|NA|NA K This enzyme acetylates the N-terminal alanine of ribosomal protein S18 OLIIENHM_01119 1209984.BN978_00772 8.6e-166 589.7 Mycobacteriaceae tsaD GO:0000287,GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140030,GO:0140032,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 ko:K01409,ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 R10648 RC00070,RC00416 ko00000,ko00001,ko00002,ko01000,ko02044,ko03016 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 Bacteria 234FK@1762,2GJ98@201174,COG0533@1,COG0533@2 NA|NA|NA J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction OLIIENHM_01120 258533.BN977_04712 2.1e-50 205.3 Mycobacteriaceae Bacteria 239FN@1762,2IIIU@201174,COG5517@1,COG5517@2 NA|NA|NA Q SnoaL-like domain OLIIENHM_01121 1150599.MPHLEI_09354 4.7e-48 196.8 Mycobacteriaceae groS GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0019899,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0035375,GO:0035966,GO:0040007,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046872,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141 ko:K04078 ko00000,ko03029,ko03110 Bacteria 23A39@1762,2IKTH@201174,COG0234@1,COG0234@2 NA|NA|NA O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter OLIIENHM_01122 931627.MycrhDRAFT_0801 2.4e-263 914.4 Mycobacteriaceae groL GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006457,GO:0006458,GO:0006725,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009295,GO:0009408,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016465,GO:0030312,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042026,GO:0042262,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043388,GO:0043590,GO:0044093,GO:0044183,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0050896,GO:0051082,GO:0051098,GO:0051099,GO:0051101,GO:0051716,GO:0061077,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090143,GO:0090304,GO:0097159,GO:0101031,GO:1901360,GO:1901363,GO:1990220,GO:2000677,GO:2000679 ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 Bacteria 232B0@1762,2GKC9@201174,COG0459@1,COG0459@2 NA|NA|NA O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions OLIIENHM_01125 164757.Mjls_0396 4e-21 108.2 Mycobacteriaceae rsbW 2.7.11.1 ko:K04757 ko00000,ko01000,ko01001,ko03021 Bacteria 23B26@1762,2GQFJ@201174,COG2172@1,COG2172@2 NA|NA|NA T Histidine kinase-like ATPase domain OLIIENHM_01126 931627.MycrhDRAFT_0819 3.7e-76 291.2 Mycobacteriaceae ko:K21472 ko00000,ko01000,ko01002,ko01011 Bacteria 234IQ@1762,2GNCG@201174,COG0741@1,COG0741@2 NA|NA|NA M lytic transglycosylase activity OLIIENHM_01128 710685.MycrhN_0825 8.2e-39 166.4 Mycobacteriaceae Bacteria 23AAH@1762,2E4PN@1,2HS2U@201174,32ZIA@2 NA|NA|NA OLIIENHM_01129 710421.Mycch_1109 3.1e-44 184.1 Mycobacteriaceae whiB3 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0008152,GO:0009273,GO:0009405,GO:0009987,GO:0010565,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0019216,GO:0019217,GO:0019222,GO:0019725,GO:0030312,GO:0031323,GO:0042546,GO:0042592,GO:0043254,GO:0044085,GO:0044087,GO:0044419,GO:0044464,GO:0045454,GO:0048037,GO:0048583,GO:0050789,GO:0050794,GO:0051128,GO:0051536,GO:0051539,GO:0051540,GO:0051704,GO:0055114,GO:0062012,GO:0065007,GO:0065008,GO:0071554,GO:0071766,GO:0071840,GO:0071944,GO:0080090,GO:0080134,GO:0090034,GO:0097159,GO:1901363,GO:1902882 ko:K18955 ko00000,ko03000 Bacteria 23A5M@1762,2CC1Y@1,2IQS5@201174,32S23@2 NA|NA|NA K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA OLIIENHM_01130 931627.MycrhDRAFT_0824 3.2e-75 288.5 Mycobacteriaceae Bacteria 233QX@1762,2F0NR@1,2GUJF@201174,33TR6@2 NA|NA|NA OLIIENHM_01131 1440774.Y900_007390 3.1e-55 221.1 Mycobacteriaceae sigD GO:0000988,GO:0000990,GO:0002791,GO:0003674,GO:0006355,GO:0006950,GO:0008150,GO:0009266,GO:0009405,GO:0009408,GO:0009628,GO:0009889,GO:0010468,GO:0010556,GO:0010565,GO:0016987,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032879,GO:0032880,GO:0043254,GO:0044087,GO:0044419,GO:0050708,GO:0050789,GO:0050794,GO:0050896,GO:0051046,GO:0051049,GO:0051128,GO:0051171,GO:0051223,GO:0051252,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0070201,GO:0080090,GO:0090087,GO:0140110,GO:1903506,GO:1903530,GO:2000112,GO:2000142,GO:2001141 ko:K03088 ko00000,ko03021 Bacteria 2336F@1762,2GM8T@201174,COG1595@1,COG1595@2 NA|NA|NA K Belongs to the sigma-70 factor family. ECF subfamily OLIIENHM_01132 1440774.Y900_007385 3e-67 262.7 Mycobacteriaceae rsdA GO:0005575,GO:0005576 ko:K21471 ko00000,ko01000,ko01002,ko01011 Bacteria 235DN@1762,2DVAJ@1,2GS36@201174,33V1E@2 NA|NA|NA S Anti-sigma-D factor RsdA to sigma factor binding region OLIIENHM_01133 1440774.Y900_007380 7e-71 273.1 Mycobacteriaceae Bacteria 238RU@1762,2DHRC@1,2II2K@201174,32U9K@2 NA|NA|NA S Family of unknown function (DUF5319) OLIIENHM_01134 1463857.JOFZ01000004_gene2858 3.7e-86 325.1 Actinobacteria bcsA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006629,GO:0006725,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009273,GO:0009698,GO:0009699,GO:0009714,GO:0009715,GO:0009987,GO:0016020,GO:0016043,GO:0019438,GO:0019748,GO:0022607,GO:0032991,GO:0034081,GO:0042180,GO:0042181,GO:0042546,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0071554,GO:0071704,GO:0071766,GO:0071770,GO:0071840,GO:0071944,GO:1901360,GO:1901362,GO:1901576 ko:K16167 ko00000,ko01008 Bacteria 2GV0U@201174,COG3424@1,COG3424@2 NA|NA|NA Q synthase OLIIENHM_01135 1440053.JOEI01000011_gene4769 9.2e-63 246.5 Actinobacteria ypbQ ko:K16168 ko00000,ko01008 Bacteria 2IG52@201174,COG1755@1,COG1755@2 NA|NA|NA S Isoprenylcysteine carboxyl methyltransferase OLIIENHM_01137 931627.MycrhDRAFT_0979 5.6e-61 240.4 Mycobacteriaceae accBC 6.3.4.14,6.4.1.2,6.4.1.3 ko:K11263 ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00741 R00742,R01859,R04385 RC00040,RC00097,RC00253,RC00367,RC00609 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv3285 Bacteria 233EW@1762,2GIZP@201174,COG4770@1,COG4770@2 NA|NA|NA I carboxylase OLIIENHM_01139 1440774.Y900_006690 4.1e-118 431.0 Mycobacteriaceae sigB GO:0000988,GO:0000990,GO:0003674,GO:0005488,GO:0005515,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006629,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0006995,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009267,GO:0009409,GO:0009605,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0032774,GO:0033554,GO:0034059,GO:0034641,GO:0034645,GO:0034654,GO:0036293,GO:0042221,GO:0042594,GO:0043170,GO:0043175,GO:0043254,GO:0043562,GO:0043620,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0070417,GO:0070482,GO:0071496,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2000142,GO:2001141 ko:K03090 ko00000,ko03021 Bacteria 234DY@1762,2GKSY@201174,COG1191@1,COG1191@2 NA|NA|NA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released OLIIENHM_01140 931627.MycrhDRAFT_0968 4.6e-52 210.7 Mycobacteriaceae rsbW GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036094,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 2.7.11.1 ko:K04757 ko00000,ko01000,ko01001,ko03021 Bacteria 238PJ@1762,2IFG9@201174,COG2172@1,COG2172@2 NA|NA|NA T Anti-sigma regulatory factor (Ser Thr protein kinase) OLIIENHM_01141 164757.Mjls_1307 3.4e-118 431.8 Mycobacteriaceae Bacteria 232G7@1762,2I2EE@201174,COG0297@1,COG0297@2 NA|NA|NA G PFAM Glycosyl transferase, group 1 OLIIENHM_01142 1440774.Y900_006705 5.6e-187 660.6 Mycobacteriaceae yhfW GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0044424,GO:0044464,GO:0055114 ko:K09471 ko00330,ko01100,map00330,map01100 M00136 R07415 RC00062 ko00000,ko00001,ko00002,ko01000 Bacteria 2347V@1762,2GJB4@201174,COG0665@1,COG0665@2,COG0723@1,COG0723@2 NA|NA|NA CE FAD dependent oxidoreductase OLIIENHM_01145 350058.Mvan_4744 1.7e-10 72.0 Mycobacteriaceae Bacteria 23BGN@1762,2B4VS@1,2GU2K@201174,31ETQ@2 NA|NA|NA OLIIENHM_01146 931627.MycrhDRAFT_0963 5.6e-73 280.8 Mycobacteriaceae Bacteria 23C19@1762,2C8AX@1,2GX2A@201174,2ZES5@2 NA|NA|NA S PknH-like extracellular domain OLIIENHM_01147 931627.MycrhDRAFT_0933 1.4e-177 629.0 Mycobacteriaceae MA20_04980 Bacteria 235ZB@1762,2GK79@201174,COG0596@1,COG0596@2 NA|NA|NA K Alpha beta hydrolase OLIIENHM_01148 216594.MMAR_2932 7e-30 136.0 Mycobacteriaceae ko:K05337 ko00000 Bacteria 23ANZ@1762,2GR5R@201174,COG1141@1,COG1141@2 NA|NA|NA C 4Fe-4S single cluster domain of Ferredoxin I OLIIENHM_01149 931627.MycrhDRAFT_0929 8e-239 832.8 Mycobacteriaceae 1.18.1.3,1.7.1.15 ko:K00362,ko:K00529 ko00071,ko00360,ko00910,ko01120,ko01220,map00071,map00360,map00910,map01120,map01220 M00530,M00545 R00787,R02000,R06782,R06783 RC00098,RC00176 br01602,ko00000,ko00001,ko00002,ko01000 Bacteria 2330A@1762,2GJKT@201174,COG0446@1,COG0446@2 NA|NA|NA S Reductase C-terminal OLIIENHM_01150 557599.MKAN_01285 1.4e-170 605.9 Mycobacteriaceae cyp147G1 Bacteria 233V5@1762,2GJ8V@201174,COG2124@1,COG2124@2 NA|NA|NA C cytochrome p450 OLIIENHM_01151 931627.MycrhDRAFT_0928 1.4e-210 738.8 Mycobacteriaceae cyp147G1 Bacteria 233V5@1762,2GJ8V@201174,COG2124@1,COG2124@2 NA|NA|NA C cytochrome p450 OLIIENHM_01152 1440774.Y900_006775 0.0 2429.1 Mycobacteriaceae lhr GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 ko:K03724 ko00000,ko01000,ko03400 Bacteria 232D2@1762,2GJG3@201174,COG1201@1,COG1201@2 NA|NA|NA L dead DEAH box helicase OLIIENHM_01153 164757.Mjls_3655 1.3e-09 71.2 Mycobacteriaceae Bacteria 236FI@1762,2A5HF@1,2I8Z4@201174,30U7N@2 NA|NA|NA OLIIENHM_01154 935567.JAES01000019_gene1051 6.7e-130 470.3 Xanthomonadales Bacteria 1QV1N@1224,1T49N@1236,1XD92@135614,COG3170@1,COG3170@2 NA|NA|NA NU Protein of unknown function (DUF1631) OLIIENHM_01155 1440774.Y900_014640 1e-123 449.5 Mycobacteriaceae 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 Bacteria 232B9@1762,2GIX8@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_01156 931627.MycrhDRAFT_2579 6e-248 863.2 Mycobacteriaceae fadD4 6.2.1.3 ko:K00666,ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 Bacteria 23466@1762,2GJAA@201174,COG0318@1,COG0318@2 NA|NA|NA IQ Activates fatty acids by binding to coenzyme A OLIIENHM_01157 36809.MAB_4502c 7.1e-32 142.9 Mycobacteriaceae pckG GO:0000003,GO:0001655,GO:0001822,GO:0001889,GO:0003006,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004457,GO:0004611,GO:0004613,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006066,GO:0006071,GO:0006082,GO:0006089,GO:0006090,GO:0006091,GO:0006094,GO:0006109,GO:0006111,GO:0006113,GO:0006139,GO:0006163,GO:0006464,GO:0006629,GO:0006631,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007028,GO:0007154,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007296,GO:0007610,GO:0008150,GO:0008152,GO:0008906,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009166,GO:0009167,GO:0009179,GO:0009185,GO:0009199,GO:0009205,GO:0009259,GO:0009267,GO:0009410,GO:0009605,GO:0009607,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009889,GO:0009966,GO:0009967,GO:0009987,GO:0009991,GO:0010033,GO:0010106,GO:0010243,GO:0010646,GO:0010647,GO:0010675,GO:0010906,GO:0014070,GO:0014074,GO:0015036,GO:0015980,GO:0016020,GO:0016042,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016054,GO:0016301,GO:0016310,GO:0016491,GO:0016614,GO:0016651,GO:0016667,GO:0016668,GO:0016740,GO:0016772,GO:0016773,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017001,GO:0017144,GO:0018130,GO:0018991,GO:0019098,GO:0019222,GO:0019249,GO:0019318,GO:0019319,GO:0019320,GO:0019362,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019516,GO:0019538,GO:0019541,GO:0019543,GO:0019563,GO:0019626,GO:0019637,GO:0019659,GO:0019660,GO:0019661,GO:0019666,GO:0019674,GO:0019693,GO:0019725,GO:0019751,GO:0019752,GO:0019953,GO:0022412,GO:0022414,GO:0023051,GO:0023056,GO:0030003,GO:0030145,GO:0030154,GO:0030312,GO:0030703,GO:0030855,GO:0031323,GO:0031667,GO:0031668,GO:0031669,GO:0031960,GO:0031974,GO:0032501,GO:0032502,GO:0032504,GO:0032787,GO:0032868,GO:0032869,GO:0032870,GO:0033554,GO:0033993,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035690,GO:0036211,GO:0042221,GO:0042493,GO:0042592,GO:0042594,GO:0042737,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043255,GO:0043412,GO:0043434,GO:0043436,GO:0043687,GO:0043900,GO:0043903,GO:0043949,GO:0043950,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044267,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045471,GO:0046031,GO:0046034,GO:0046164,GO:0046174,GO:0046364,GO:0046365,GO:0046394,GO:0046395,GO:0046434,GO:0046459,GO:0046483,GO:0046496,GO:0046677,GO:0046683,GO:0046700,GO:0046872,GO:0046914,GO:0046916,GO:0047134,GO:0048468,GO:0048477,GO:0048513,GO:0048518,GO:0048522,GO:0048545,GO:0048562,GO:0048568,GO:0048583,GO:0048584,GO:0048598,GO:0048609,GO:0048646,GO:0048731,GO:0048732,GO:0048856,GO:0048869,GO:0048878,GO:0050789,GO:0050792,GO:0050794,GO:0050801,GO:0050896,GO:0051186,GO:0051384,GO:0051591,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055086,GO:0055114,GO:0060429,GO:0061005,GO:0061008,GO:0062012,GO:0065007,GO:0065008,GO:0070013,GO:0070365,GO:0070887,GO:0071236,GO:0071310,GO:0071361,GO:0071375,GO:0071383,GO:0071384,GO:0071385,GO:0071396,GO:0071407,GO:0071417,GO:0071466,GO:0071495,GO:0071496,GO:0071548,GO:0071549,GO:0071704,GO:0071840,GO:0071944,GO:0072001,GO:0072071,GO:0072329,GO:0072330,GO:0072521,GO:0072524,GO:0075136,GO:0080090,GO:0097159,GO:0097237,GO:0097305,GO:0097306,GO:0097327,GO:0098771,GO:1901135,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901575,GO:1901576,GO:1901615,GO:1901616,GO:1901617,GO:1901652,GO:1901653,GO:1901654,GO:1901655,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902533 4.1.1.32,4.1.1.49 ko:K01596,ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964 M00003,M00170 R00341,R00431,R00726 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2638 Bacteria 233QW@1762,2GJH3@201174,COG1274@1,COG1274@2 NA|NA|NA C Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle OLIIENHM_01158 318424.EU78_07655 7.7e-112 409.8 Mycobacteriaceae ahcY GO:0000096,GO:0000098,GO:0000166,GO:0003674,GO:0003824,GO:0004013,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009087,GO:0009116,GO:0009119,GO:0009987,GO:0016020,GO:0016054,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0019899,GO:0022610,GO:0030260,GO:0030312,GO:0033353,GO:0034641,GO:0035375,GO:0035635,GO:0036094,GO:0040007,GO:0042278,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0044650,GO:0046085,GO:0046128,GO:0046395,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0048037,GO:0050662,GO:0051186,GO:0051287,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0055086,GO:0070403,GO:0071704,GO:0071944,GO:0072521,GO:0097159,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901657 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 Bacteria 233A0@1762,2GK2Q@201174,COG0499@1,COG0499@2 NA|NA|NA H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine OLIIENHM_01159 1122247.C731_1333 8.3e-79 300.1 Mycobacteriaceae tmk GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004798,GO:0005488,GO:0005515,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009129,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009161,GO:0009165,GO:0009173,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009218,GO:0009219,GO:0009221,GO:0009259,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046044,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046872,GO:0046940,GO:0046983,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.1.1.45,2.7.4.9,4.1.1.19 ko:K00560,ko:K00943,ko:K01585 ko00240,ko00330,ko00670,ko01100,ko01523,map00240,map00330,map00670,map01100,map01523 M00053,M00133 R00566,R02094,R02098,R02101 RC00002,RC00219,RC00299,RC00332 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS00680,iNJ661.Rv3247c Bacteria 235DY@1762,2HNUW@201174,COG0125@1,COG0125@2 NA|NA|NA F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis OLIIENHM_01160 1380386.JIAW01000017_gene3164 1.7e-279 968.4 Mycobacteriaceae recC GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0004518,GO:0004519,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.11.5 ko:K03583 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 233WA@1762,2GNVB@201174,COG1330@1,COG1330@2 NA|NA|NA L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity OLIIENHM_01161 1380386.JIAW01000017_gene3163 0.0 1600.9 Mycobacteriaceae recB GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 3.1.11.5,3.6.4.12 ko:K03582,ko:K16898 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 232R7@1762,2GNKH@201174,COG1074@1,COG1074@2 NA|NA|NA L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA OLIIENHM_01162 1440774.Y900_013850 1.4e-229 802.4 Mycobacteriaceae recD GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 3.1.11.5 ko:K03581 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 233JH@1762,2GIX1@201174,COG0507@1,COG0507@2 NA|NA|NA L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD OLIIENHM_01163 931627.MycrhDRAFT_3307 4.1e-10 72.4 Mycobacteriaceae GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.1.1.3 ko:K01046 ko00561,ko01100,map00561,map01100 M00098 R02250,R02687 RC00020,RC00037,RC00041,RC00094 ko00000,ko00001,ko00002,ko01000 Bacteria 236D7@1762,2IA49@201174,COG5651@1,COG5651@2 NA|NA|NA N PPE family OLIIENHM_01164 47839.CCAU010000002_gene2661 3e-71 274.6 Mycobacteriaceae ysnB ko:K07095 ko00000 Bacteria 238Q6@1762,2IFVB@201174,COG0622@1,COG0622@2 NA|NA|NA S Phosphoesterase OLIIENHM_01165 931627.MycrhDRAFT_2437 1.2e-30 139.0 Mycobacteriaceae Bacteria 23AS3@1762,2C1WU@1,2ISDK@201174,347YG@2 NA|NA|NA OLIIENHM_01166 1440774.Y900_013885 2e-163 582.0 Mycobacteriaceae mct GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0015977,GO:0016853,GO:0016866,GO:0016867,GO:0043427,GO:0071704 5.4.1.3 ko:K14470 ko00720,ko01120,ko01200,map00720,map01120,map01200 M00376 R09283 RC02480 ko00000,ko00001,ko00002,ko01000 Bacteria 233F3@1762,2GNF4@201174,COG1804@1,COG1804@2 NA|NA|NA C dehydratase OLIIENHM_01167 1440774.Y900_013890 3.3e-88 331.6 Mycobacteriaceae tesB ko:K10805 ko01040,map01040 ko00000,ko00001,ko01000,ko01004 Bacteria 235BE@1762,2IA9S@201174,COG1946@1,COG1946@2 NA|NA|NA I Acyl-CoA thioesterase OLIIENHM_01168 931627.MycrhDRAFT_2441 3.8e-52 210.7 Mycobacteriaceae fadE1 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 Bacteria 232CR@1762,2GKQI@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_01169 1157943.KB892705_gene2256 0.0 1384.8 Mycobacteriaceae acnA GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005506,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008198,GO:0009060,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0030312,GO:0030350,GO:0032787,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046459,GO:0046872,GO:0046914,GO:0047456,GO:0048037,GO:0050896,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 234YF@1762,2GJD5@201174,COG1048@1,COG1048@2 NA|NA|NA C aconitate hydratase OLIIENHM_01170 1078020.KEK_01745 3.9e-16 90.1 Mycobacteriaceae Bacteria 23B7N@1762,2E4I7@1,2IQBB@201174,32ZDA@2 NA|NA|NA S transcriptional regulator OLIIENHM_01171 1440774.Y900_000750 9.4e-284 982.2 Mycobacteriaceae yheS_1 ko:K06158 ko00000,ko03012 Bacteria 235J4@1762,2GKQ4@201174,COG0488@1,COG0488@2 NA|NA|NA S ABC transporter OLIIENHM_01172 931627.MycrhDRAFT_4991 2.6e-125 454.9 Mycobacteriaceae echA12 GO:0003674,GO:0003824,GO:0004300,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 Bacteria 23552@1762,2GJ7Z@201174,COG1024@1,COG1024@2 NA|NA|NA I Belongs to the enoyl-CoA hydratase isomerase family OLIIENHM_01173 350058.Mvan_2740 1.3e-47 195.7 Mycobacteriaceae trxA GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.8.1.8,1.8.1.9 ko:K00384,ko:K03671,ko:K03672 ko00450,ko04621,ko05418,map00450,map04621,map05418 R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000,ko03110 Bacteria 2397W@1762,2IKP1@201174,COG0526@1,COG0526@2 NA|NA|NA O belongs to the thioredoxin family OLIIENHM_01174 1440774.Y900_000770 1.9e-70 272.3 Mycobacteriaceae Bacteria 238TQ@1762,2A84P@1,2IN6P@201174,30X5E@2 NA|NA|NA OLIIENHM_01175 710686.Mycsm_04138 6.1e-56 224.2 Mycobacteriaceae Bacteria 238FK@1762,2ADI3@1,2IDJ7@201174,3138B@2 NA|NA|NA OLIIENHM_01176 931627.MycrhDRAFT_5340 0.0 1489.6 Mycobacteriaceae fbiC GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044464,GO:0044689,GO:0050896,GO:0051186,GO:0051188,GO:0051409,GO:0071944 2.5.1.77 ko:K11779 ko00680,ko01120,map00680,map01120 M00378 R09396 RC01381,RC03002,RC03007 ko00000,ko00001,ko00002,ko01000 Bacteria 236ER@1762,2GK83@201174,COG1060@1,COG1060@2 NA|NA|NA H catalyzes radical-mediated transfer of hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) OLIIENHM_01177 419947.MRA_1183 1.1e-12 80.9 Bacteria 3.1.1.3 ko:K01046 ko00561,ko01100,map00561,map01100 M00098 R02250,R02687 RC00020,RC00037,RC00041,RC00094 ko00000,ko00001,ko00002,ko01000 Bacteria COG0657@1,COG0657@2 NA|NA|NA I acetylesterase activity OLIIENHM_01178 1341646.CBMO010000106_gene4128 8e-34 149.8 Mycobacteriaceae Bacteria 23AQP@1762,2AY9H@1,2IQAH@201174,31QBU@2 NA|NA|NA OLIIENHM_01179 1440774.Y900_019315 6.8e-116 423.7 Mycobacteriaceae mshB GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0010125,GO:0010126,GO:0016020,GO:0016137,GO:0016138,GO:0016787,GO:0016810,GO:0016811,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659 3.5.1.103 ko:K15525 ko00000,ko01000 Bacteria 234M9@1762,2GKUM@201174,COG2120@1,COG2120@2 NA|NA|NA S Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway OLIIENHM_01180 931627.MycrhDRAFT_5348 1.6e-45 190.3 Mycobacteriaceae Bacteria 23DE7@1762,2B68H@1,2H1QH@201174,31Z5S@2 NA|NA|NA OLIIENHM_01181 931627.MycrhDRAFT_5349 7.8e-250 869.8 Mycobacteriaceae lpqW GO:0005575,GO:0005576,GO:0005623,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0030288,GO:0030313,GO:0031975,GO:0040007,GO:0042597,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 Bacteria 2363A@1762,2GJ9N@201174,COG0747@1,COG0747@2 NA|NA|NA E Monoacyl phosphatidylinositol tetramannoside-binding protein OLIIENHM_01182 164757.Mjls_4269 0.0 1152.9 Mycobacteriaceae typA GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840 ko:K06207 ko00000 Bacteria 233P2@1762,2GJUJ@201174,COG1217@1,COG1217@2 NA|NA|NA T GTP-binding protein TypA OLIIENHM_01183 931627.MycrhDRAFT_5355 1.9e-44 185.3 Mycobacteriaceae mutT2 3.6.1.55 ko:K03574,ko:K13669 ko00000,ko01000,ko01003,ko03400 GT87 Bacteria 239XM@1762,2IQEA@201174,COG1051@1,COG1051@2 NA|NA|NA F Belongs to the Nudix hydrolase family OLIIENHM_01184 710685.MycrhN_3632 6.4e-34 149.8 Mycobacteriaceae phhB 3.5.4.33,4.2.1.96 ko:K01724,ko:K11991 ko00790,map00790 R04734,R10223 RC00477,RC01208 ko00000,ko00001,ko01000,ko03016,ko04147 Bacteria 23A0X@1762,2IKXR@201174,COG2154@1,COG2154@2 NA|NA|NA H dehydratase OLIIENHM_01185 931627.MycrhDRAFT_5358 7e-183 646.7 Mycobacteriaceae pimE GO:0000026,GO:0000030,GO:0003674,GO:0003824,GO:0004376,GO:0004377,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0070085,GO:0071704,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.7.53,3.6.1.13,3.6.1.55 ko:K01515,ko:K03574,ko:K13669,ko:K19710 ko00230,map00230 R00126,R01054,R01618 RC00002,RC02753,RC02795 ko00000,ko00001,ko01000,ko01003,ko03400 GT87 Bacteria 23417@1762,2I2P7@201174,COG1051@1,COG1051@2 NA|NA|NA F GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity OLIIENHM_01186 1440774.Y900_019250 1.9e-32 146.0 Mycobacteriaceae Bacteria 23CIV@1762,2DA1D@1,2H3II@201174,32GUB@2 NA|NA|NA OLIIENHM_01187 931627.MycrhDRAFT_5360 1.6e-100 372.9 Mycobacteriaceae Bacteria 234BQ@1762,2CDJB@1,2H6GE@201174,33SXJ@2 NA|NA|NA OLIIENHM_01188 931627.MycrhDRAFT_5361 2.3e-153 548.9 Mycobacteriaceae atfA1 2.3.1.20 ko:K00635 ko00561,ko01100,map00561,map01100 M00089 R02251 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 Bacteria 23298@1762,2GPHZ@201174,COG1020@1,COG1020@2 NA|NA|NA I Belongs to the long-chain O-acyltransferase family OLIIENHM_01189 710686.Mycsm_04939 1.1e-15 88.2 Mycobacteriaceae Bacteria 23B6W@1762,2C7N6@1,2GQSQ@201174,2ZFXQ@2 NA|NA|NA OLIIENHM_01190 1440774.Y900_019230 4.2e-80 304.3 Mycobacteriaceae nth 4.2.99.18 ko:K07457,ko:K10773 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 232IW@1762,2GNE5@201174,COG0177@1,COG0177@2 NA|NA|NA L HhH-GPD family OLIIENHM_01191 350058.Mvan_1838 3.1e-47 196.1 Mycobacteriaceae Bacteria 237ZD@1762,2IDSD@201174,COG5651@1,COG5651@2 NA|NA|NA N pfam pe-ppe OLIIENHM_01192 931627.MycrhDRAFT_5365 1.9e-172 612.1 Mycobacteriaceae 2.7.13.3,3.1.3.3 ko:K02478,ko:K07315,ko:K07704 ko02020,map02020 M00492 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko03021 Bacteria 234XX@1762,2GJD4@201174,COG3275@1,COG3275@2 NA|NA|NA T Histidine kinase OLIIENHM_01193 1440774.Y900_019215 9.5e-109 399.8 Mycobacteriaceae lytT GO:0000156,GO:0000160,GO:0003674,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0023052,GO:0035556,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007 ko:K02477,ko:K07705 ko02020,map02020 M00492 ko00000,ko00001,ko00002,ko02022 Bacteria 235T3@1762,2GKK5@201174,COG3279@1,COG3279@2 NA|NA|NA KT response regulator OLIIENHM_01194 931627.MycrhDRAFT_5367 5.6e-41 173.7 Mycobacteriaceae Bacteria 239WX@1762,2E3NY@1,2II83@201174,32YM2@2 NA|NA|NA OLIIENHM_01195 1223545.GS4_32_00380 2.8e-225 788.1 Gordoniaceae Bacteria 2GM3H@201174,4GCT8@85026,COG4147@1,COG4147@2 NA|NA|NA S Sodium:solute symporter family OLIIENHM_01196 1440774.Y900_019200 2.1e-47 194.9 Mycobacteriaceae Bacteria 23A89@1762,2IQ5D@201174,COG3162@1,COG3162@2 NA|NA|NA S Protein of unknown function, DUF485 OLIIENHM_01197 931627.MycrhDRAFT_5370 2.6e-193 681.8 Mycobacteriaceae actP ko:K14393 ko00000,ko02000 2.A.21.7 Bacteria 2353Z@1762,2GJ56@201174,COG4147@1,COG4147@2 NA|NA|NA S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family OLIIENHM_01199 875328.JDM601_0820 8e-12 75.5 Mycobacteriaceae arfB GO:0008150,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0051704 ko:K16192 ko00000 Bacteria 23BY3@1762,2AYBF@1,2GZRG@201174,31QE3@2 NA|NA|NA OLIIENHM_01200 547163.BN979_04793 1.4e-69 270.0 Mycobacteriaceae ompA GO:0003674,GO:0005215,GO:0005488,GO:0005539,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0009268,GO:0009279,GO:0009628,GO:0010447,GO:0015267,GO:0015288,GO:0015696,GO:0016020,GO:0016021,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0030312,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0034220,GO:0040007,GO:0042834,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044403,GO:0044419,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044462,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051704,GO:0055085,GO:0071705,GO:0071944,GO:0072488,GO:0097367,GO:0098655 ko:K03286,ko:K16191 ko00000,ko02000 1.B.6,1.B.6.1.3 Bacteria 237JV@1762,2HXT6@201174,COG2885@1,COG2885@2 NA|NA|NA M Belongs to the ompA family OLIIENHM_01201 1122247.C731_3619 8.2e-55 219.5 Mycobacteriaceae fkb 5.2.1.8 ko:K01802,ko:K03772 ko00000,ko01000,ko03110 Bacteria 239F5@1762,2IHQC@201174,COG0545@1,COG0545@2 NA|NA|NA O Peptidyl-prolyl cis-trans isomerase OLIIENHM_01202 246196.MSMEI_5517 6e-211 740.3 Mycobacteriaceae GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 Bacteria 2335H@1762,2GMUC@201174,COG1233@1,COG1233@2 NA|NA|NA Q NAD(P)-binding Rossmann-like domain OLIIENHM_01203 246196.MSMEI_5522 3.4e-228 797.3 Mycobacteriaceae gltA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2350N@1762,2GJ7E@201174,COG0372@1,COG0372@2 NA|NA|NA C Belongs to the citrate synthase family OLIIENHM_01204 931627.MycrhDRAFT_0535 2.9e-53 215.3 Mycobacteriaceae tcmR Bacteria 23A9C@1762,2HWK3@201174,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family OLIIENHM_01205 1209984.BN978_04108 8.2e-174 616.7 Mycobacteriaceae entS_1 Bacteria 234Y0@1762,2GKFJ@201174,COG0477@1,COG0477@2 NA|NA|NA EGP Transmembrane secretion effector OLIIENHM_01206 931627.MycrhDRAFT_0532 5e-92 344.0 Mycobacteriaceae pdxH 1.4.3.5 ko:K00275 ko00750,ko01100,ko01120,map00750,map01100,map01120 M00124 R00277,R00278,R01710,R01711 RC00048,RC00116 ko00000,ko00001,ko00002,ko01000 Bacteria 233CG@1762,2GJCR@201174,COG0259@1,COG0259@2 NA|NA|NA H Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) OLIIENHM_01207 1440774.Y900_001175 7e-166 590.1 Mycobacteriaceae carA GO:0000050,GO:0003674,GO:0003824,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0032991,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01955,ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 iAPECO1_1312.APECO1_1950,iNJ661.Rv1383,iUTI89_1310.UTI89_C0036,iYO844.BSU15510,ic_1306.c0040 Bacteria 235VE@1762,2GKFA@201174,COG0505@1,COG0505@2 NA|NA|NA F Belongs to the CarA family OLIIENHM_01208 1440774.Y900_001180 3e-61 241.5 Mycobacteriaceae Bacteria 238QP@1762,2GM9I@201174,COG0505@1,COG0505@2 NA|NA|NA EF Belongs to the CarA family OLIIENHM_01209 931627.MycrhDRAFT_4908 9.4e-210 736.1 Mycobacteriaceae pyrC GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 Bacteria 2345J@1762,2GJ0T@201174,COG0044@1,COG0044@2 NA|NA|NA F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily OLIIENHM_01210 1440774.Y900_001190 5.3e-154 550.4 Mycobacteriaceae pyrB GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 ko:K00608,ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 iYO844.BSU15490 Bacteria 234NF@1762,2GKNA@201174,COG0540@1,COG0540@2 NA|NA|NA F Belongs to the ATCase OTCase family OLIIENHM_01211 1440774.Y900_001195 3.3e-90 337.8 Mycobacteriaceae pyrR GO:0003674,GO:0003700,GO:0003824,GO:0004845,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006220,GO:0006221,GO:0006355,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0031323,GO:0031326,GO:0034641,GO:0034654,GO:0043094,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046390,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0055086,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0080090,GO:0090407,GO:0140110,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141 2.4.2.9 ko:K02825 ko00240,ko01100,map00240,map01100 R00966 RC00063 ko00000,ko00001,ko01000,ko03000 iHN637.CLJU_RS05275 Bacteria 23445@1762,2GJNP@201174,COG2065@1,COG2065@2 NA|NA|NA F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant OLIIENHM_01212 1440774.Y900_001200 1.1e-193 682.6 Mycobacteriaceae GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 232D3@1762,2H2SY@201174,COG1680@1,COG1680@2 NA|NA|NA V beta-lactamase OLIIENHM_01213 931627.MycrhDRAFT_1531 8.6e-32 143.7 Mycobacteriaceae Bacteria 23851@1762,2B2ZI@1,2IF4C@201174,31VKP@2 NA|NA|NA OLIIENHM_01214 931627.MycrhDRAFT_4903 2.7e-63 249.6 Mycobacteriaceae nusB GO:0008150,GO:0040007 ko:K03625 ko00000,ko03009,ko03021 Bacteria 238TZ@1762,2IM3D@201174,COG0781@1,COG0781@2 NA|NA|NA K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons OLIIENHM_01215 557599.MKAN_26480 1.3e-94 352.4 Mycobacteriaceae efp GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02356 ko00000,ko03012 Bacteria 233EF@1762,2GJMS@201174,COG0231@1,COG0231@2 NA|NA|NA J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase OLIIENHM_01216 931627.MycrhDRAFT_4901 6.2e-154 550.4 Mycobacteriaceae pepQ GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0016787,GO:0019538,GO:0030145,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.11.9,3.4.13.9 ko:K01262,ko:K01271 ko00000,ko01000,ko01002 Bacteria 2346V@1762,2GM7D@201174,COG0006@1,COG0006@2 NA|NA|NA E Creatinase/Prolidase N-terminal domain OLIIENHM_01217 1440774.Y900_001275 2.3e-46 192.2 Mycobacteriaceae Bacteria 2346N@1762,28VVH@1,2IAUS@201174,2ZHX1@2 NA|NA|NA OLIIENHM_01218 931627.MycrhDRAFT_4897 1.5e-63 248.8 Mycobacteriaceae aroQ GO:0003674,GO:0003824,GO:0003855,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:1901576 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 iIT341.HP1038 Bacteria 238KX@1762,2IMBY@201174,COG0757@1,COG0757@2 NA|NA|NA E Catalyzes a trans-dehydration via an enolate intermediate OLIIENHM_01219 1440774.Y900_001290 3.5e-165 587.8 Mycobacteriaceae aroB GO:0003674,GO:0003824,GO:0003856,GO:0005488,GO:0005507,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.71,4.2.3.4 ko:K01735,ko:K13829 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412,R03083 RC00002,RC00078,RC00847 ko00000,ko00001,ko00002,ko01000 Bacteria 2347Q@1762,2GIUZ@201174,COG0337@1,COG0337@2 NA|NA|NA E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) OLIIENHM_01220 1440774.Y900_001295 9e-79 300.1 Mycobacteriaceae aroK GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0019438,GO:0019632,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71,4.2.3.4 ko:K00891,ko:K13829 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412,R03083 RC00002,RC00078,RC00847 ko00000,ko00001,ko00002,ko01000 Bacteria 232EV@1762,2GRFW@201174,COG0703@1,COG0703@2 NA|NA|NA F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate OLIIENHM_01221 710686.Mycsm_02796 7.6e-179 633.3 Mycobacteriaceae aroC GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016491,GO:0016651,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_0976,iNJ661.Rv2540c Bacteria 233E4@1762,2GJJN@201174,COG0082@1,COG0082@2 NA|NA|NA E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system OLIIENHM_01222 1440774.Y900_001345 6.3e-33 147.1 Mycobacteriaceae pppA 3.4.23.43 ko:K02278,ko:K02654 M00331 ko00000,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15.2 Bacteria 23AMX@1762,2HS5K@201174,COG1989@1,COG1989@2 NA|NA|NA NOU peptidase OLIIENHM_01223 931627.MycrhDRAFT_4892 4.9e-108 397.5 Mycobacteriaceae aroE GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv2552c Bacteria 232UW@1762,2GPQQ@201174,COG0169@1,COG0169@2 NA|NA|NA E shikimate 5-dehydrogenase OLIIENHM_01224 931627.MycrhDRAFT_4891 5e-128 464.5 Mycobacteriaceae mltG ko:K07082 ko00000 Bacteria 2349Q@1762,2GKGQ@201174,COG1559@1,COG1559@2 NA|NA|NA S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation OLIIENHM_01225 931627.MycrhDRAFT_4890 1e-60 239.6 Mycobacteriaceae yqgF GO:0000966,GO:0000967,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0140097,GO:1901360 ko:K07447 ko00000,ko01000 Bacteria 239EX@1762,2IQB0@201174,COG0816@1,COG0816@2 NA|NA|NA J Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA OLIIENHM_01226 1440774.Y900_001365 0.0 1530.8 Mycobacteriaceae alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 233PU@1762,2GIUG@201174,COG0013@1,COG0013@2 NA|NA|NA J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain OLIIENHM_01227 525368.HMPREF0591_5797 1.1e-44 185.7 Mycobacteriaceae GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 Bacteria 2398U@1762,2IHWS@201174,COG0432@1,COG0432@2 NA|NA|NA S Uncharacterised protein family UPF0047 OLIIENHM_01228 931627.MycrhDRAFT_4883 1.3e-201 709.1 Mycobacteriaceae rarA ko:K07478 ko00000 Bacteria 232EZ@1762,2GKDP@201174,COG2256@1,COG2256@2 NA|NA|NA L aaa ATPase OLIIENHM_01230 1440774.Y900_001415 1e-103 383.3 Mycobacteriaceae Bacteria 233TC@1762,2H0K9@201174,COG2141@1,COG2141@2 NA|NA|NA C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases OLIIENHM_01232 1440774.Y900_013375 2.6e-69 268.9 Mycobacteriaceae GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 Bacteria 233QT@1762,2GKZP@201174,COG3266@1,COG3266@2 NA|NA|NA S Transmembrane domain of unknown function (DUF3566) OLIIENHM_01233 216594.MMAR_0006 0.0 1511.1 Mycobacteriaceae gyrA GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 5.99.1.3 ko:K02469 ko00000,ko01000,ko03032,ko03400 Bacteria 233TD@1762,2GJ2Q@201174,COG0188@1,COG0188@2 NA|NA|NA L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner OLIIENHM_01234 710421.Mycch_0006 0.0 1164.4 Mycobacteriaceae gyrB GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0034335,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360 5.99.1.3 ko:K02470 ko00000,ko01000,ko03032,ko03400 Bacteria 235GQ@1762,2GKGP@201174,COG0187@1,COG0187@2 NA|NA|NA L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner OLIIENHM_01235 1193181.BN10_1010013 2.7e-24 118.6 Intrasporangiaceae 2.7.7.80,2.8.1.11 ko:K21147 ko04122,map04122 R07459,R07461 RC00043 ko00000,ko00001,ko01000 Bacteria 2GR81@201174,4FHT9@85021,COG0607@1,COG0607@2 NA|NA|NA P Rhodanese Homology Domain OLIIENHM_01236 931627.MycrhDRAFT_2294 6.4e-66 256.9 Mycobacteriaceae Bacteria 232VD@1762,2GNQ4@201174,COG5512@1,COG5512@2 NA|NA|NA S Belongs to the UPF0232 family OLIIENHM_01237 931627.MycrhDRAFT_2293 6.8e-180 636.7 Mycobacteriaceae recF GO:0000731,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0018130,GO:0019438,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901576 ko:K03629,ko:K07459 ko03440,map03440 ko00000,ko00001,ko03400 Bacteria 233RS@1762,2GJCS@201174,COG1195@1,COG1195@2 NA|NA|NA L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP OLIIENHM_01238 1440774.Y900_013350 1.2e-144 519.2 Mycobacteriaceae gnd 1.1.1.343,1.1.1.44 ko:K00033 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200 M00004,M00006 R01528,R10221 RC00001,RC00539 ko00000,ko00001,ko00002,ko01000 Bacteria 232XI@1762,2I2DH@201174,COG1023@1,COG1023@2 NA|NA|NA G 6-phosphogluconate dehydrogenase OLIIENHM_01239 931627.MycrhDRAFT_2291 9e-175 619.8 Mycobacteriaceae dnaN GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 235PH@1762,2GJK3@201174,COG0592@1,COG0592@2 NA|NA|NA L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria OLIIENHM_01240 1121405.dsmv_0789 4.7e-117 427.9 Desulfobacterales degT 2.6.1.98 ko:K13017 ko00520,map00520 R10141 RC00006,RC00781 ko00000,ko00001,ko01000,ko01005,ko01007 Bacteria 1MUPN@1224,2MHV3@213118,2WJ1Q@28221,42M4C@68525,COG0399@1,COG0399@2 NA|NA|NA E Belongs to the DegT DnrJ EryC1 family OLIIENHM_01241 1410632.JHWW01000002_gene2165 5.5e-45 187.6 unclassified Lachnospiraceae wbpD Bacteria 1TT21@1239,24CCH@186801,27MA8@186928,COG0110@1,COG0110@2 NA|NA|NA S Hexapeptide repeat of succinyl-transferase OLIIENHM_01242 656519.Halsa_0331 2.9e-73 282.3 Clostridia mviM ko:K03810 ko00000 Bacteria 1V0J1@1239,24IDB@186801,COG0673@1,COG0673@2 NA|NA|NA S Oxidoreductase family, NAD-binding Rossmann fold OLIIENHM_01243 1265310.CCBD010000080_gene5030 3.5e-169 601.7 Mycobacteriaceae Bacteria 2333U@1762,2IBZD@201174,COG0463@1,COG0463@2,COG4122@1,COG4122@2 NA|NA|NA M Glycosyl transferase family 2 OLIIENHM_01244 931627.MycrhDRAFT_5037 0.0 2255.7 Mycobacteriaceae dnaE GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 232SQ@1762,2GJ1P@201174,COG0587@1,COG0587@2 NA|NA|NA L DNA polymerase OLIIENHM_01245 1380386.JIAW01000011_gene3280 7.8e-64 250.4 Mycobacteriaceae Bacteria 237XC@1762,2GIW8@201174,COG4291@1,COG4291@2 NA|NA|NA S membrane OLIIENHM_01246 1209984.BN978_07114 1.1e-66 259.2 Mycobacteriaceae GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0030312,GO:0031406,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0070967,GO:0071944,GO:0097159,GO:0097367,GO:1901363 2.7.1.83 ko:K16328 ko00240,map00240 R03315 RC00002,RC00017 ko00000,ko00001,ko01000 Bacteria 238P5@1762,2I3KG@201174,COG1846@1,COG1846@2 NA|NA|NA K nitroreductase OLIIENHM_01247 1440774.Y900_000445 1.7e-203 715.3 Mycobacteriaceae ilvA GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009987,GO:0016020,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901605 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1559 Bacteria 233IP@1762,2GJAG@201174,COG1171@1,COG1171@2 NA|NA|NA E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA OLIIENHM_01248 931627.MycrhDRAFT_5050 2.2e-11 74.3 Mycobacteriaceae treZ GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009251,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016052,GO:0016787,GO:0016798,GO:0030978,GO:0030980,GO:0033942,GO:0034637,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0071704,GO:1901575,GO:1901576 3.2.1.141 ko:K01236 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11256 RC00049 ko00000,ko00001,ko00002,ko01000 CBM48,GH13 Bacteria 234GA@1762,2GMIS@201174,COG0296@1,COG0296@2 NA|NA|NA G 4-alpha-D-((1- 4)-alpha-D-glucano)trehalose trehalohydrolase OLIIENHM_01250 931627.MycrhDRAFT_3184 3.8e-301 1040.4 Mycobacteriaceae 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 Bacteria 232VV@1762,2GIRF@201174,COG2217@1,COG2217@2 NA|NA|NA P ATPase, P-type (transporting), HAD superfamily, subfamily IC OLIIENHM_01251 710685.MycrhN_1097 1.9e-10 71.6 Mycobacteriaceae Bacteria 23B6G@1762,2B01S@1,2GQIR@201174,31SBZ@2 NA|NA|NA OLIIENHM_01252 931627.MycrhDRAFT_3179 1.3e-43 183.0 Mycobacteriaceae Bacteria 238XV@1762,2F3K6@1,2ISTR@201174,33WDH@2 NA|NA|NA OLIIENHM_01253 350058.Mvan_0849 5.4e-21 107.5 Mycobacteriaceae Bacteria 23B87@1762,2AY3F@1,2GQTR@201174,31Q5A@2 NA|NA|NA OLIIENHM_01254 1440774.Y900_016795 9e-37 159.8 Mycobacteriaceae Bacteria 239WG@1762,2ASBH@1,2IG7W@201174,31HQR@2 NA|NA|NA OLIIENHM_01255 700508.D174_05495 3.7e-150 537.7 Mycobacteriaceae hemB GO:0000287,GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 iECABU_c1320.ECABU_c04500,iEcSMS35_1347.EcSMS35_0398,iJN746.PP_2913,ic_1306.c0477 Bacteria 234Q5@1762,2GJJ0@201174,COG0113@1,COG0113@2 NA|NA|NA H Belongs to the ALAD family OLIIENHM_01256 931627.MycrhDRAFT_3175 5.8e-273 946.4 Mycobacteriaceae hemD GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 ko:K02302,ko:K02303,ko:K13542 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03165,R03194,R03947 RC00003,RC00871,RC01012,RC01034,RC01861 ko00000,ko00001,ko00002,ko01000 Bacteria 2342U@1762,2GMJZ@201174,COG0007@1,COG0007@2,COG1587@1,COG1587@2 NA|NA|NA H Uroporphyrinogen-III synthase OLIIENHM_01257 1440774.Y900_016780 6e-150 537.0 Mycobacteriaceae hemC GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv0510 Bacteria 232HH@1762,2GMWI@201174,COG0181@1,COG0181@2 NA|NA|NA H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps OLIIENHM_01258 931627.MycrhDRAFT_3173 2.2e-193 681.8 Mycobacteriaceae hemA GO:0005575,GO:0005623,GO:0008150,GO:0009288,GO:0040007,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040 1.2.1.70 ko:K02407,ko:K02492 ko00860,ko01100,ko01110,ko01120,ko02040,map00860,map01100,map01110,map01120,map02040 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000,ko02035 iSB619.SA_RS08420 Bacteria 233ZZ@1762,2GJRA@201174,COG0373@1,COG0373@2 NA|NA|NA H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) OLIIENHM_01259 931627.MycrhDRAFT_3172 4.5e-31 140.2 Mycobacteriaceae GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 23AJ9@1762,2IR0P@201174,COG0695@1,COG0695@2 NA|NA|NA O Glutaredoxin-like domain (DUF836) OLIIENHM_01260 931627.MycrhDRAFT_3171 3.6e-123 448.0 Mycobacteriaceae serB1 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K21830 ko00000 Bacteria 233YR@1762,2GJW9@201174,COG0560@1,COG0560@2 NA|NA|NA E Hydrolase OLIIENHM_01261 1440774.Y900_016760 5.6e-78 297.0 Mycobacteriaceae GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 Bacteria 236YK@1762,2GMVC@201174,COG2030@1,COG2030@2 NA|NA|NA I Belongs to the UPF0336 family OLIIENHM_01262 931627.MycrhDRAFT_3169 4.4e-146 524.2 Mycobacteriaceae GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 2328Z@1762,2GJKH@201174,COG0204@1,COG0204@2 NA|NA|NA I Acyltransferase OLIIENHM_01263 931627.MycrhDRAFT_3168 2.4e-166 591.7 Mycobacteriaceae galE2 GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv0501 Bacteria 232CQ@1762,2GNT1@201174,COG0451@1,COG0451@2 NA|NA|NA GM epimerase dehydratase OLIIENHM_01264 318424.EU78_03605 5.5e-32 143.3 Mycobacteriaceae xis Bacteria 23B8R@1762,2GQGV@201174,COG3311@1,COG3311@2 NA|NA|NA K DNA binding domain, excisionase family OLIIENHM_01265 931627.MycrhDRAFT_3165 6.3e-101 374.0 Mycobacteriaceae proC GO:0000287,GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0030145,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 Bacteria 234Y2@1762,2GJ7D@201174,COG0345@1,COG0345@2 NA|NA|NA E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline OLIIENHM_01266 1440774.Y900_016735 1.1e-99 369.8 Mycobacteriaceae Bacteria 232TU@1762,2I2SA@201174,COG2050@1,COG2050@2 NA|NA|NA Q Thioesterase-like superfamily OLIIENHM_01267 931627.MycrhDRAFT_3163 9.9e-144 516.2 Mycobacteriaceae Bacteria 232Z0@1762,2GJ6E@201174,COG1082@1,COG1082@2 NA|NA|NA G TIM barrel OLIIENHM_01268 1440774.Y900_016725 3.9e-58 232.3 Mycobacteriaceae GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944 Bacteria 234TC@1762,2DY9N@1,2GKWP@201174,348T2@2 NA|NA|NA OLIIENHM_01269 931627.MycrhDRAFT_3161 2e-134 485.3 Mycobacteriaceae ppx GO:0003674,GO:0003824,GO:0006793,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0044237 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 R03409 RC00002 ko00000,ko00001,ko01000 Bacteria 23517@1762,2GMME@201174,COG0248@1,COG0248@2 NA|NA|NA FP Ppx GppA phosphatase OLIIENHM_01270 1440774.Y900_016715 1.1e-135 489.2 Mycobacteriaceae Bacteria 2345K@1762,28IRH@1,2GJW6@201174,2Z8QX@2 NA|NA|NA OLIIENHM_01271 931627.MycrhDRAFT_3158 8e-155 553.5 Mycobacteriaceae ko:K16703 ko00000,ko01000,ko01003 GT4 Bacteria 237VW@1762,2HEYD@201174,COG0438@1,COG0438@2 NA|NA|NA M PFAM Glycosyl transferase, group 1 OLIIENHM_01272 350054.Mflv_1500 7.9e-152 543.5 Mycobacteriaceae Bacteria 23847@1762,2GNIU@201174,COG0438@1,COG0438@2 NA|NA|NA M PFAM Glycosyl transferase, group 1 OLIIENHM_01273 350054.Mflv_1499 3.8e-104 385.6 Mycobacteriaceae Bacteria 2372W@1762,2DKW5@1,2IMFS@201174,30J7Z@2 NA|NA|NA OLIIENHM_01275 487521.OCU_13040 1.7e-272 945.3 Mycobacteriaceae ko:K07497 ko00000 Bacteria 233XH@1762,2HITH@201174,COG2801@1,COG2801@2,COG3415@1,COG3415@2 NA|NA|NA L Integrase core domain OLIIENHM_01276 1209984.BN978_01318 9.7e-123 446.8 Mycobacteriaceae Bacteria 237WN@1762,2GKXH@201174,COG2842@1,COG2842@2 NA|NA|NA S Bacterial TniB protein OLIIENHM_01277 710687.KI912270_gene4412 1.7e-157 563.5 Mycobacteriaceae Bacteria 2363S@1762,2GNFI@201174,COG0583@1,COG0583@2 NA|NA|NA K TniQ OLIIENHM_01278 258533.BN977_02879 4.1e-111 409.1 Mycobacteriaceae Bacteria 2363S@1762,2GNFI@201174,COG0583@1,COG0583@2 NA|NA|NA K TniQ OLIIENHM_01279 350054.Mflv_0885 7.9e-13 79.0 Mycobacteriaceae Bacteria 23BCK@1762,2B045@1,2GQMT@201174,31SEI@2 NA|NA|NA K Helix-turn-helix domain OLIIENHM_01280 1157943.KB892705_gene2071 1.5e-78 299.3 Mycobacteriaceae Bacteria 2341Y@1762,2AQS6@1,2I9R6@201174,31G00@2 NA|NA|NA OLIIENHM_01281 1298864.AUEQ01000009_gene3004 1.2e-125 456.1 Mycobacteriaceae Bacteria 23EVB@1762,2GK6P@201174,COG4221@1,COG4221@2 NA|NA|NA S Fungal family of unknown function (DUF1776) OLIIENHM_01282 1380386.JIAW01000001_gene4742 2.4e-39 168.3 Mycobacteriaceae Bacteria 23BRH@1762,2EQWK@1,2GTKH@201174,30WT7@2 NA|NA|NA S Domain of unknown function (DUF4345) OLIIENHM_01283 1356852.N008_17120 6.8e-08 64.7 Cytophagia crtA 1.14.15.9 ko:K09847 ko00906,ko01100,map00906,map01100 R07525,R07526,R07537,R07538 RC02084 ko00000,ko00001,ko01000 Bacteria 29UQ5@1,30G1W@2,47Q8T@768503,4NKX5@976 NA|NA|NA Q spheroidene monooxygenase OLIIENHM_01284 321955.AAGP01000042_gene2648 8.6e-63 246.5 Actinobacteria MA20_27405 Bacteria 2IJ48@201174,COG2050@1,COG2050@2 NA|NA|NA Q protein possibly involved in aromatic compounds catabolism OLIIENHM_01285 931627.MycrhDRAFT_5278 1.3e-122 446.0 Mycobacteriaceae Bacteria 2356G@1762,2I0NW@201174,COG2267@1,COG2267@2 NA|NA|NA I Serine aminopeptidase, S33 OLIIENHM_01286 1298864.AUEQ01000015_gene1529 1.2e-128 466.1 Mycobacteriaceae 3.1.1.24 ko:K01055 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00568 R02991 RC00825 ko00000,ko00001,ko00002,ko01000 Bacteria 23FFH@1762,2I3WE@201174,COG0596@1,COG0596@2 NA|NA|NA S Serine aminopeptidase, S33 OLIIENHM_01287 1123258.AQXZ01000015_gene4557 3.5e-83 315.1 Nocardiaceae Bacteria 2GPAJ@201174,4G6SJ@85025,COG4221@1,COG4221@2 NA|NA|NA S 3-beta hydroxysteroid dehydrogenase/isomerase family OLIIENHM_01288 1172186.KB911463_gene3670 1.7e-179 635.6 Mycobacteriaceae Bacteria 2329C@1762,2GK8E@201174,COG1902@1,COG1902@2 NA|NA|NA C NADH:flavin oxidoreductase / NADH oxidase family OLIIENHM_01289 1298864.AUEQ01000009_gene3002 3.9e-90 337.8 Mycobacteriaceae Bacteria 23F62@1762,2I3EJ@201174,COG1028@1,COG1028@2 NA|NA|NA IQ to the short-chain dehydrogenases reductases (SDR) family OLIIENHM_01290 931627.MycrhDRAFT_1462 7.1e-70 270.4 Mycobacteriaceae Bacteria 237I7@1762,2H5HE@201174,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family OLIIENHM_01291 1209984.BN978_01105 9.3e-139 499.6 Mycobacteriaceae ko:K07497 ko00000 Bacteria 236HP@1762,2HBU8@201174,COG2801@1,COG2801@2 NA|NA|NA L PFAM Integrase, catalytic region OLIIENHM_01292 1112204.GPOL_c07110 2e-40 171.4 Gordoniaceae ko:K07483,ko:K07497 ko00000 Bacteria 2IMG6@201174,4GENJ@85026,COG2963@1,COG2963@2 NA|NA|NA L Transposase OLIIENHM_01294 585530.HMPREF0183_0114 2.9e-30 139.0 Actinobacteria Bacteria 2C799@1,2IBYU@201174,341VT@2 NA|NA|NA OLIIENHM_01296 1120797.KB908256_gene2163 2e-122 445.7 Mycobacteriaceae 4.1.1.52 ko:K22213 ko00000,ko01000 Bacteria 235H7@1762,2GP75@201174,COG2159@1,COG2159@2 NA|NA|NA S Amidohydrolase OLIIENHM_01297 1123258.AQXZ01000017_gene4368 3.2e-76 292.0 Nocardiaceae Bacteria 2GMQG@201174,4G069@85025,COG1733@1,COG1733@2 NA|NA|NA K HxlR-like helix-turn-helix OLIIENHM_01298 1123023.JIAI01000002_gene5444 1.7e-95 355.9 Actinobacteria 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 R03026 RC00831 ko00000,ko00001,ko01000 Bacteria 2IBBD@201174,COG1024@1,COG1024@2 NA|NA|NA I Belongs to the enoyl-CoA hydratase isomerase family OLIIENHM_01299 710421.Mycch_1881 2.4e-84 318.5 Mycobacteriaceae cbiM ko:K02007 ko02010,map02010 M00245,M00246 ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 Bacteria 2333S@1762,2IEFC@201174,COG0310@1,COG0310@2 NA|NA|NA P Cobalt uptake substrate-specific transmembrane region OLIIENHM_01301 547163.BN979_03688 8.9e-10 69.7 Mycobacteriaceae Bacteria 239NE@1762,2DPKK@1,2IH34@201174,332IR@2 NA|NA|NA S TnsA endonuclease N terminal protein OLIIENHM_01302 262316.MAP_2726c 3.1e-54 217.6 Mycobacteriaceae fdxA ko:K05524 ko00000 Bacteria 23A6Z@1762,2IKVN@201174,COG1146@1,COG1146@2 NA|NA|NA C ferredoxin OLIIENHM_01303 487521.OCU_33280 3.6e-73 281.6 Mycobacteriaceae Bacteria 233RT@1762,2IAWJ@201174,COG2345@1,COG2345@2 NA|NA|NA K Transcriptional regulator OLIIENHM_01304 1299327.I546_4077 5.4e-42 177.2 Mycobacteriaceae Bacteria 23FJX@1762,2E3RQ@1,2I876@201174,32SHZ@2 NA|NA|NA OLIIENHM_01305 44454.NF84_15855 3e-120 438.3 Mycobacteriaceae 1.13.12.16,1.3.1.9 ko:K00459,ko:K02371 ko00061,ko00910,ko01100,ko01212,map00061,map00910,map01100,map01212 M00083 R00025,R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765 RC00052,RC00076,RC02541,RC02759 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 235GN@1762,2GKA6@201174,COG2070@1,COG2070@2 NA|NA|NA S 2-nitropropane dioxygenase OLIIENHM_01306 350054.Mflv_3489 0.0 1167.5 Mycobacteriaceae nirK 1.7.2.1 ko:K00368 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 Bacteria 23857@1762,2GPUP@201174,COG2132@1,COG2132@2,COG4454@1,COG4454@2 NA|NA|NA PQ Multicopper oxidase OLIIENHM_01307 1240349.ANGC01000018_gene870 9e-121 440.3 Actinobacteria 1.7.2.1 ko:K00368 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 Bacteria 2HG56@201174,COG4243@1,COG4243@2 NA|NA|NA Q Vitamin k epoxide reductase OLIIENHM_01308 487521.OCU_19670 3.5e-86 324.7 Mycobacteriaceae Bacteria 2390F@1762,2IAWJ@201174,COG2345@1,COG2345@2 NA|NA|NA K IclR helix-turn-helix domain OLIIENHM_01309 1122247.C731_0886 2.3e-63 248.1 Mycobacteriaceae menB GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0008150,GO:0008152,GO:0008935,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016020,GO:0016043,GO:0016829,GO:0016830,GO:0016833,GO:0022607,GO:0034214,GO:0042180,GO:0042181,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0071890,GO:0071944,GO:1901576,GO:1901661,GO:1901663 4.1.3.36 ko:K01661 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R07263 RC01923 ko00000,ko00001,ko00002,ko01000 Bacteria 232FW@1762,2GK5G@201174,COG0447@1,COG0447@2 NA|NA|NA H Belongs to the enoyl-CoA hydratase isomerase family. MenB subfamily OLIIENHM_01310 1370121.AUWS01000023_gene2094 8e-124 450.3 Mycobacteriaceae Bacteria 236TP@1762,2IC8H@201174,COG0627@1,COG0627@2 NA|NA|NA S Putative esterase OLIIENHM_01311 1265310.CCBD010000084_gene4428 2.1e-139 502.3 Mycobacteriaceae Bacteria 235U9@1762,2GR38@201174,COG2508@1,COG2508@2 NA|NA|NA QT PucR C-terminal helix-turn-helix domain OLIIENHM_01312 1146883.BLASA_5030 1.5e-139 502.7 Frankiales Bacteria 2GJSW@201174,4ES0Y@85013,COG1018@1,COG1018@2 NA|NA|NA C Oxidoreductase FAD-binding OLIIENHM_01313 1440774.Y900_019555 2.2e-77 295.0 Mycobacteriaceae Bacteria 23454@1762,2CAW2@1,2IB15@201174,32RS7@2 NA|NA|NA OLIIENHM_01314 931627.MycrhDRAFT_5292 4e-222 777.3 Mycobacteriaceae lpqY GO:0006810,GO:0008150,GO:0008643,GO:0009405,GO:0015766,GO:0015771,GO:0015772,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051179,GO:0051234,GO:0051704,GO:0071702 ko:K02027 M00207 ko00000,ko00002,ko02000 3.A.1.1 Bacteria 232JN@1762,2GM4E@201174,COG1653@1,COG1653@2 NA|NA|NA G Extracellular solute-binding protein OLIIENHM_01315 246196.MSMEI_4933 4.3e-137 494.2 Mycobacteriaceae thuF GO:0008150,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051704 ko:K02025,ko:K10118,ko:K10228,ko:K10237,ko:K15771 ko02010,map02010 M00196,M00200,M00204,M00207,M00491 ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.17,3.A.1.1.2,3.A.1.1.28,3.A.1.1.5 iNJ661.Rv1236 Bacteria 234RG@1762,2GM6N@201174,COG1175@1,COG1175@2 NA|NA|NA P ABC transporter OLIIENHM_01316 931627.MycrhDRAFT_5290 7e-134 483.4 Mycobacteriaceae sugB GO:0008150,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051704 ko:K02026 M00207 ko00000,ko00002,ko02000 3.A.1.1 Bacteria 2346G@1762,2GKEE@201174,COG0395@1,COG0395@2 NA|NA|NA P inner membrane component OLIIENHM_01317 931627.MycrhDRAFT_5289 1.4e-169 602.4 Mycobacteriaceae sugC GO:0006810,GO:0008150,GO:0008643,GO:0009405,GO:0015766,GO:0015771,GO:0015772,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051179,GO:0051234,GO:0051704,GO:0071702 ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 ko00000,ko00001,ko00002,ko02000 3.A.1.1 Bacteria 233NH@1762,2GJCM@201174,COG3842@1,COG3842@2 NA|NA|NA P Belongs to the ABC transporter superfamily OLIIENHM_01318 1440774.Y900_019580 7.1e-66 256.9 Mycobacteriaceae Bacteria 232C5@1762,2F14D@1,2GMUZ@201174,33U5Q@2 NA|NA|NA S Suppressor of fused protein (SUFU) OLIIENHM_01319 1440774.Y900_019585 4.6e-149 534.3 Mycobacteriaceae corA ko:K03284 ko00000,ko02000 1.A.35.1,1.A.35.3 Bacteria 235WH@1762,2GKNZ@201174,COG0598@1,COG0598@2 NA|NA|NA P Mediates influx of magnesium ions OLIIENHM_01320 1440774.Y900_019590 8.2e-184 649.8 Mycobacteriaceae maeB GO:0003674,GO:0003824,GO:0004470,GO:0004473,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114 1.1.1.38,1.1.1.40 ko:K00027,ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020 M00169,M00172 R00214,R00216 RC00105 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1637,iHN637.CLJU_RS18940 Bacteria 233Y2@1762,2GJAJ@201174,COG0281@1,COG0281@2 NA|NA|NA C malic enzyme OLIIENHM_01321 1440774.Y900_019595 1e-84 320.1 Mycobacteriaceae proWY ko:K05845 ko02010,map02010 M00209 ko00000,ko00001,ko00002,ko02000 3.A.1.12 Bacteria 234U9@1762,2HNID@201174,COG1732@1,COG1732@2 NA|NA|NA M ABC-type glycine betaine transport system OLIIENHM_01322 1298864.AUEQ01000008_gene2518 1.6e-122 445.7 Mycobacteriaceae GO:0000166,GO:0003674,GO:0003824,GO:0004303,GO:0005488,GO:0005496,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006694,GO:0006703,GO:0008150,GO:0008152,GO:0008202,GO:0008210,GO:0008289,GO:0008610,GO:0009058,GO:0009987,GO:0010817,GO:0016229,GO:0016491,GO:0016614,GO:0016616,GO:0033764,GO:0034754,GO:0036094,GO:0042445,GO:0042446,GO:0042562,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0065007,GO:0065008,GO:0070401,GO:0071704,GO:0097159,GO:0099130,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903924 1.1.1.401 ko:K21883 ko00051,ko01120,map00051,map01120 R11339 RC00089 ko00000,ko00001,ko01000 Bacteria 232YA@1762,2GN3I@201174,COG4221@1,COG4221@2 NA|NA|NA S Belongs to the short-chain dehydrogenases reductases (SDR) family OLIIENHM_01323 931627.MycrhDRAFT_5283 5.2e-28 130.6 Mycobacteriaceae Bacteria 23AS1@1762,2BHKI@1,2IQ7B@201174,32BP4@2 NA|NA|NA S Protein of unknown function (DUF732) OLIIENHM_01324 350058.Mvan_4477 0.0 1377.8 Mycobacteriaceae sucA GO:0000287,GO:0003674,GO:0003824,GO:0004591,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016624,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0019842,GO:0022900,GO:0030312,GO:0030976,GO:0032991,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0048037,GO:0050439,GO:0050662,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234 1.2.4.2,4.1.1.71 ko:K00164,ko:K01616 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1248c,iSSON_1240.SSON_0677,iYL1228.KPN_00732 Bacteria 23538@1762,2GIU6@201174,COG0508@1,COG0508@2,COG0567@1,COG0567@2 NA|NA|NA C Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha- ketoglutarate, KG), leading to the formation of an enamine- thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2- oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha-ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy-3-oxoadipate (HOA), which spontaneously decarboxylates to form 5-hydroxylevulinate (HLA). And is also a component of the 2-oxoglutarate dehydrogenase (ODH) complex, that catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The KG decarboxylase and KG dehydrogenase reactions provide two alternative, tightly regulated, pathways connecting the oxidative and reductive branches of the TCA cycle OLIIENHM_01325 931627.MycrhDRAFT_0982 4.5e-150 537.3 Mycobacteriaceae sseA GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 Bacteria 232Z5@1762,2GIYU@201174,COG2897@1,COG2897@2 NA|NA|NA P sulfurtransferase OLIIENHM_01326 1440774.Y900_006640 3e-79 301.6 Mycobacteriaceae maf GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0030312,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0047429,GO:0071944 1.1.1.25,2.1.1.190 ko:K00014,ko:K03215,ko:K06287 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000,ko03009 Bacteria 238X8@1762,2GNI0@201174,COG0424@1,COG0424@2 NA|NA|NA D Maf-like protein OLIIENHM_01327 1078020.KEK_22759 5.9e-29 133.3 Mycobacteriaceae iNJ661.Rv3281 Bacteria 23BA7@1762,2B02F@1,2GQJK@201174,31SCM@2 NA|NA|NA S Acyl-CoA carboxylase epsilon subunit OLIIENHM_01328 1440774.Y900_006630 9.3e-292 1008.8 Mycobacteriaceae pccB GO:0003674,GO:0003824,GO:0003989,GO:0004658,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009317,GO:0009987,GO:0015977,GO:0016020,GO:0016042,GO:0016054,GO:0016421,GO:0016874,GO:0016885,GO:0019752,GO:0030312,GO:0032787,GO:0032991,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:0071944,GO:0072329,GO:1901575,GO:1902494 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 Bacteria 2345P@1762,2GIRU@201174,COG4799@1,COG4799@2 NA|NA|NA I Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) OLIIENHM_01329 367299.JOEE01000003_gene2921 1.4e-126 459.9 Intrasporangiaceae cad 4.1.1.18,4.1.1.19 ko:K01582,ko:K01583,ko:K01585 ko00310,ko00330,ko00960,ko01100,ko01110,map00310,map00330,map00960,map01100,map01110 M00133 R00462,R00566 RC00299 ko00000,ko00001,ko00002,ko01000 iJN678.cad Bacteria 2GJ31@201174,4FJ0J@85021,COG1982@1,COG1982@2 NA|NA|NA E Orn/Lys/Arg decarboxylase, C-terminal domain OLIIENHM_01330 258533.BN977_04932 2e-67 261.9 Mycobacteriaceae Bacteria 23467@1762,2GK6Y@201174,COG3428@1,COG3428@2 NA|NA|NA S Bacterial PH domain OLIIENHM_01331 1078020.KEK_22739 3e-89 334.7 Mycobacteriaceae ko:K07015 ko00000 Bacteria 233H7@1762,2IFFV@201174,COG2246@1,COG2246@2 NA|NA|NA S membrane OLIIENHM_01332 1440774.Y900_006535 1.3e-178 632.5 Mycobacteriaceae purK GO:0000166,GO:0003674,GO:0003824,GO:0004638,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016829,GO:0016830,GO:0016831,GO:0016874,GO:0016879,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034028,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.4.18 ko:K01589 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07404 RC01927 ko00000,ko00001,ko00002,ko01000 iECUMN_1333.ECUMN_0562,iYL1228.KPN_00477 Bacteria 236I9@1762,2GJCU@201174,COG0026@1,COG0026@2 NA|NA|NA F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) OLIIENHM_01333 1078020.KEK_22729 1.4e-68 265.8 Mycobacteriaceae purE GO:0008150,GO:0040007 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 iJN678.purE,iNJ661.Rv3275c Bacteria 23697@1762,2IFFD@201174,COG0041@1,COG0041@2 NA|NA|NA F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) OLIIENHM_01334 164757.Mjls_1336 4.6e-200 703.7 Mycobacteriaceae fadE25 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 Bacteria 2344D@1762,2GIX8@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_01335 1440774.Y900_009600 5.6e-42 176.8 Mycobacteriaceae gcvT 1.5.99.5,2.1.2.10 ko:K00605,ko:K06980,ko:K22086 ko00260,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200 M00532 R00609,R01221,R02300,R04125 RC00022,RC00069,RC00183,RC00190,RC00557,RC02834 ko00000,ko00001,ko00002,ko01000,ko03016 Bacteria 233N2@1762,2I4ER@201174,COG0404@1,COG0404@2 NA|NA|NA E Belongs to the GcvT family OLIIENHM_01336 1041522.MCOL_V226577 7.8e-14 82.4 Mycobacteriaceae Bacteria 23B7A@1762,2EGRW@1,2IQF3@201174,33AI2@2 NA|NA|NA S Protein of unknown function (DUF3073) OLIIENHM_01337 1440774.Y900_009610 2.5e-184 651.4 Mycobacteriaceae purM GO:0003674,GO:0003824,GO:0004641,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.1,6.3.4.13 ko:K01933,ko:K11788 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144,R04208 RC00090,RC00166,RC01100 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1844,iECSF_1327.ECSF_2340 Bacteria 232WN@1762,2GJNY@201174,COG0150@1,COG0150@2 NA|NA|NA F Phosphoribosylformylglycinamidine cyclo-ligase OLIIENHM_01338 1440774.Y900_009615 4e-89 334.3 Mycobacteriaceae Bacteria 2371P@1762,2IJG5@201174,COG5587@1,COG5587@2 NA|NA|NA S Conserved hypothetical protein (DUF2461) OLIIENHM_01339 1341646.CBMO010000123_gene2111 1.7e-80 307.0 Mycobacteriaceae Bacteria 2370G@1762,2GJVW@201174,COG1574@1,COG1574@2 NA|NA|NA S amidohydrolase OLIIENHM_01340 1440774.Y900_009620 3e-32 144.8 Mycobacteriaceae Bacteria 23ATB@1762,2IRV4@201174,COG1917@1,COG1917@2 NA|NA|NA S Cupin 2, conserved barrel domain protein OLIIENHM_01341 1440774.Y900_009625 4.4e-199 700.7 Mycobacteriaceae Bacteria 23531@1762,2GIZA@201174,COG0702@1,COG0702@2 NA|NA|NA GM epimerase dehydratase OLIIENHM_01342 931627.MycrhDRAFT_0360 6.3e-258 896.3 Mycobacteriaceae purF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009507,GO:0009536,GO:0040007,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 Bacteria 234ZM@1762,2GK6I@201174,COG0034@1,COG0034@2 NA|NA|NA F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine OLIIENHM_01343 350058.Mvan_5115 7.7e-38 163.3 Mycobacteriaceae Bacteria 23A0H@1762,2IQBF@201174,COG3255@1,COG3255@2 NA|NA|NA I Sterol carrier protein OLIIENHM_01344 710687.KI912270_gene3829 1.2e-24 119.8 Mycobacteriaceae ko:K07052 ko00000 Bacteria 238PG@1762,2IFZG@201174,COG1266@1,COG1266@2 NA|NA|NA S infection protein OLIIENHM_01345 1078020.KEK_18338 1e-166 592.8 Mycobacteriaceae nusA GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0040007,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 ko:K02600 ko00000,ko03009,ko03021 Bacteria 2357R@1762,2GJDJ@201174,COG0195@1,COG0195@2 NA|NA|NA K Participates in both transcription termination and antitermination OLIIENHM_01346 1408452.JAGZ01000003_gene4993 4.2e-55 221.1 Mycobacteriaceae rimP GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576 ko:K09748 ko00000,ko03009 Bacteria 238JC@1762,2I9BT@201174,COG0779@1,COG0779@2 NA|NA|NA S Required for maturation of 30S ribosomal subunits OLIIENHM_01347 931627.MycrhDRAFT_7003 1e-32 146.7 Mycobacteriaceae Bacteria 238T8@1762,2DYRJ@1,2IKA5@201174,34ATC@2 NA|NA|NA OLIIENHM_01348 931627.MycrhDRAFT_7004 4.9e-55 220.7 Mycobacteriaceae Bacteria 239BC@1762,2DSVA@1,2I867@201174,33HJF@2 NA|NA|NA S Domain of unknown function (DUF4439) OLIIENHM_01349 1078020.KEK_18358 4.7e-289 1000.0 Mycobacteriaceae proS GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 2349Z@1762,2GJ9G@201174,COG0442@1,COG0442@2 NA|NA|NA J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS OLIIENHM_01350 479431.Namu_3404 1.5e-146 526.6 Frankiales Bacteria 2GJVW@201174,4EWII@85013,COG1574@1,COG1574@2 NA|NA|NA S Amidohydrolase family OLIIENHM_01351 710685.MycrhN_5680 1.6e-213 748.8 Mycobacteriaceae Bacteria 236IU@1762,2HEV1@201174,COG0477@1,COG0477@2 NA|NA|NA EGP Pfam Major Facilitator Superfamily OLIIENHM_01352 1440774.Y900_003035 1.6e-240 838.6 Mycobacteriaceae efpA GO:0008150,GO:0040007 Bacteria 2349W@1762,2HNBE@201174,COG0477@1,COG0477@2 NA|NA|NA EGP Major facilitator Superfamily OLIIENHM_01353 931627.MycrhDRAFT_6879 1.3e-184 652.5 Mycobacteriaceae cysG GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009628,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.13.11.79,1.3.1.76,2.1.1.107,2.1.1.131,3.7.1.12,4.99.1.4 ko:K02302,ko:K02303,ko:K02304,ko:K04719,ko:K13541 ko00740,ko00860,ko01100,ko01110,ko01120,map00740,map00860,map01100,map01110,map01120 M00121 R02864,R03194,R03947,R05180,R05809,R07772,R09083 RC00003,RC00435,RC00871,RC01012,RC01034,RC01293,RC01545,RC02097,RC02413,RC03471 ko00000,ko00001,ko00002,ko01000 iECIAI1_1343.ECIAI1_3507,iECSE_1348.ECSE_3630,iEcE24377_1341.EcE24377A_3838,iJN746.PP_3999,iPC815.YPO0158 Bacteria 234BY@1762,2GK3B@201174,COG0007@1,COG0007@2,COG1648@1,COG1648@2 NA|NA|NA H uroporphyrin-III c-methyltransferase OLIIENHM_01354 1440774.Y900_003045 1.5e-181 642.5 Mycobacteriaceae cobB GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 6.3.5.11,6.3.5.9 ko:K02224 ko00860,ko01100,ko01120,map00860,map01100,map01120 R05224,R05815 RC00010,RC01301 ko00000,ko00001,ko01000 Bacteria 23398@1762,2GJ3R@201174,COG1797@1,COG1797@2 NA|NA|NA H Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L-glutamine or ammonia as the nitrogen source OLIIENHM_01355 262316.MAP_2918c 7.5e-93 346.7 Mycobacteriaceae cobO 2.5.1.17 ko:K19221 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv2849c Bacteria 2331D@1762,2GNJQ@201174,COG2109@1,COG2109@2 NA|NA|NA H ATP corrinoid adenosyltransferase OLIIENHM_01356 931627.MycrhDRAFT_6876 8.5e-249 866.3 Mycobacteriaceae bchI 6.6.1.1 ko:K03404,ko:K03405,ko:K13580 ko00860,ko01100,ko01110,map00860,map01100,map01110 R03877 RC01012 ko00000,ko00001,ko01000 Bacteria 233TG@1762,2GN3S@201174,COG1239@1,COG1239@2,COG1240@1,COG1240@2 NA|NA|NA H von Willebrand factor, type A OLIIENHM_01357 258533.BN977_05590 4.9e-65 253.8 Mycobacteriaceae elaA GO:0003674,GO:0003824,GO:0006464,GO:0006473,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 ko:K02348 ko00000 Bacteria 234AD@1762,2IFAM@201174,COG2153@1,COG2153@2 NA|NA|NA S Acetyltransferase (GNAT) domain OLIIENHM_01358 931627.MycrhDRAFT_6874 2.5e-238 831.2 Mycobacteriaceae mqo GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0008924,GO:0009898,GO:0016020,GO:0016491,GO:0016614,GO:0016615,GO:0016901,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071944,GO:0097159,GO:0098552,GO:0098562,GO:1901265,GO:1901363 1.1.5.4 ko:K00116 ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00009,M00011 R00360,R00361,R01257 RC00031 ko00000,ko00001,ko00002,ko01000 iE2348C_1286.E2348C_2355,iEC55989_1330.EC55989_2465,iJN746.PP_1251,iSB619.SA_RS12375 Bacteria 235TS@1762,2GJZ8@201174,COG0579@1,COG0579@2 NA|NA|NA C malate quinone oxidoreductase OLIIENHM_01359 931627.MycrhDRAFT_6873 3.8e-139 501.1 Mycobacteriaceae Bacteria 232U1@1762,2GIVB@201174,COG2267@1,COG2267@2 NA|NA|NA I Serine aminopeptidase, S33 OLIIENHM_01360 1150599.MPHLEI_24019 6.6e-102 377.1 Mycobacteriaceae cbiO ko:K02006,ko:K02008 ko02010,map02010 M00245,M00246 ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 Bacteria 233WF@1762,2GJ0M@201174,COG1122@1,COG1122@2 NA|NA|NA P ABC transporter OLIIENHM_01361 350054.Mflv_4056 3.6e-100 371.3 Mycobacteriaceae cbiQ ko:K02006,ko:K02008 ko02010,map02010 M00245,M00246 ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 Bacteria 233CB@1762,2GKQ7@201174,COG0619@1,COG0619@2 NA|NA|NA P Cobalt ABC transporter OLIIENHM_01362 350058.Mvan_2292 4.4e-32 144.1 Mycobacteriaceae cbiL ko:K02007,ko:K02009,ko:K16915 ko02010,map02010 M00245,M00246 ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 iAF987.Gmet_2441 Bacteria 23AGQ@1762,2IS99@201174,COG0310@1,COG0310@2 NA|NA|NA P PDGLE domain OLIIENHM_01363 710421.Mycch_2028 1.7e-83 315.8 Mycobacteriaceae cbiM ko:K02007,ko:K16915 ko02010,map02010 M00245,M00246 ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 Bacteria 236KJ@1762,2GK2U@201174,COG0310@1,COG0310@2 NA|NA|NA P PFAM cobalamin (vitamin B12) biosynthesis CbiM OLIIENHM_01364 1440774.Y900_003125 1.5e-39 168.7 Mycobacteriaceae ko:K21903 ko00000,ko03000 Bacteria 23A55@1762,2GR57@201174,COG0640@1,COG0640@2 NA|NA|NA K regulatory protein, arsR OLIIENHM_01365 1440774.Y900_003185 9.8e-92 343.2 Mycobacteriaceae ko:K05799 ko00000,ko03000 Bacteria 236EZ@1762,2HQFA@201174,COG2186@1,COG2186@2 NA|NA|NA K GntR family OLIIENHM_01366 547163.BN979_03266 1.7e-121 442.2 Mycobacteriaceae Bacteria 233Z3@1762,2GJGM@201174,COG1028@1,COG1028@2 NA|NA|NA IQ Dehydrogenase OLIIENHM_01367 1440774.Y900_003195 5.7e-226 790.0 Mycobacteriaceae aldC 1.2.1.3,1.2.1.39,1.2.1.8 ko:K00128,ko:K00130,ko:K00146 ko00010,ko00053,ko00071,ko00260,ko00280,ko00310,ko00330,ko00340,ko00360,ko00380,ko00410,ko00561,ko00620,ko00625,ko00643,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00260,map00280,map00310,map00330,map00340,map00360,map00380,map00410,map00561,map00620,map00625,map00643,map00903,map00981,map01100,map01110,map01120,map01130 M00135,M00555 R00264,R00631,R00710,R00904,R01752,R01986,R02536,R02549,R02565,R02566,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 Bacteria 232XE@1762,2GIWZ@201174,COG1012@1,COG1012@2 NA|NA|NA C Belongs to the aldehyde dehydrogenase family OLIIENHM_01368 1440774.Y900_003200 6.2e-105 387.1 Mycobacteriaceae puuD 4.1.3.27 ko:K01658,ko:K07010 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000,ko01002 Bacteria 234UX@1762,2GIV6@201174,COG2071@1,COG2071@2 NA|NA|NA S glutamine amidotransferase OLIIENHM_01369 931627.MycrhDRAFT_6602 1.7e-222 778.5 Mycobacteriaceae glnA4 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 Bacteria 233C3@1762,2GM3K@201174,COG0174@1,COG0174@2 NA|NA|NA E glutamine synthetase OLIIENHM_01370 931627.MycrhDRAFT_6601 9.8e-251 872.5 Mycobacteriaceae eat ko:K16238 ko00000,ko02000 2.A.3.5 Bacteria 236MF@1762,2GM7U@201174,COG0833@1,COG0833@2 NA|NA|NA E amino acid OLIIENHM_01371 1440774.Y900_003225 2.6e-84 318.2 Mycobacteriaceae Bacteria 2338G@1762,2I95T@201174,COG0596@1,COG0596@2 NA|NA|NA S Alpha beta hydrolase OLIIENHM_01372 931627.MycrhDRAFT_6592 1e-79 303.1 Mycobacteriaceae Bacteria 232V9@1762,29D1E@1,2I2BA@201174,2ZZZG@2 NA|NA|NA OLIIENHM_01373 1440774.Y900_003235 6.4e-207 726.9 Mycobacteriaceae cobQ GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.5.10 ko:K02232 ko00860,ko01100,map00860,map01100 M00122 R05225 RC00010,RC01302 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS15780,iJN678.cbiP,iYL1228.KPN_03184 Bacteria 232PX@1762,2GJ1W@201174,COG1492@1,COG1492@2 NA|NA|NA H Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation OLIIENHM_01374 931627.MycrhDRAFT_6590 6.1e-149 533.5 Mycobacteriaceae map GO:0000096,GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0006082,GO:0006464,GO:0006508,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009066,GO:0009987,GO:0010467,GO:0016151,GO:0016485,GO:0016787,GO:0019538,GO:0019752,GO:0030145,GO:0035551,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0046872,GO:0046914,GO:0050897,GO:0051604,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0140096,GO:1901564,GO:1901605 3.4.11.18 ko:K01265 ko00000,ko01000,ko01002 Bacteria 234IJ@1762,2GKIZ@201174,COG0024@1,COG0024@2 NA|NA|NA E Methionine aminopeptidase OLIIENHM_01375 931627.MycrhDRAFT_6589 1.1e-83 316.2 Mycobacteriaceae Bacteria 234CX@1762,2GXVR@201174,COG4758@1,COG4758@2 NA|NA|NA S Domain of unknown function (DUF1707) OLIIENHM_01376 1440774.Y900_003250 4e-31 141.0 Mycobacteriaceae Bacteria 23ABC@1762,2IKSY@201174,COG2146@1,COG2146@2 NA|NA|NA P PFAM Rieske 2Fe-2S OLIIENHM_01377 1440774.Y900_003265 1.3e-270 938.7 Mycobacteriaceae pbp2B 3.4.16.4 ko:K01286 ko00000,ko01000 Bacteria 232NZ@1762,2GJAM@201174,COG0768@1,COG0768@2 NA|NA|NA M penicillin-binding protein OLIIENHM_01378 931627.MycrhDRAFT_6584 1.7e-130 472.2 Mycobacteriaceae ko:K06976 ko00000 Bacteria 233XD@1762,2GMD2@201174,COG3393@1,COG3393@2 NA|NA|NA S acetyltransferase OLIIENHM_01379 931627.MycrhDRAFT_6583 1.9e-198 698.4 Mycobacteriaceae ispG GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009055,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0022900,GO:0030312,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044464,GO:0046429,GO:0046490,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0052592,GO:0055114,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS06430,iJN678.gcpE Bacteria 2329G@1762,2GK2S@201174,COG0821@1,COG0821@2 NA|NA|NA I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate OLIIENHM_01380 1380386.JIAW01000002_gene5522 8.7e-181 639.8 Mycobacteriaceae rseP GO:0008150,GO:0040007 ko:K11749 ko02024,ko04112,map02024,map04112 ko00000,ko00001,ko01000,ko01002 Bacteria 2337E@1762,2GJJT@201174,COG0750@1,COG0750@2 NA|NA|NA M peptidase OLIIENHM_01381 1440774.Y900_003290 7.8e-179 633.3 Mycobacteriaceae dxr GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0050897,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 iAPECO1_1312.APECO1_1814,iECOK1_1307.ECOK1_0174,iECS88_1305.ECS88_0183,iHN637.CLJU_RS06420,iNJ661.Rv2870c,iUMN146_1321.UM146_23670,iUTI89_1310.UTI89_C0188 Bacteria 2332G@1762,2GIRV@201174,COG0743@1,COG0743@2 NA|NA|NA I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) OLIIENHM_01382 710686.Mycsm_02422 5.3e-66 257.7 Mycobacteriaceae mpt83 GO:0005575,GO:0005576,GO:0005615,GO:0005623,GO:0005886,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043207,GO:0044403,GO:0044419,GO:0044421,GO:0044464,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071944,GO:0075136 ko:K03286 ko00000,ko02000 1.B.6 Bacteria 233Z4@1762,2GJC2@201174,COG2335@1,COG2335@2 NA|NA|NA M Fasciclin OLIIENHM_01383 318424.EU78_10260 1e-62 246.5 Mycobacteriaceae mpt70 ko:K03286 ko00000,ko02000 1.B.6 Bacteria 23369@1762,2GJC2@201174,COG2335@1,COG2335@2 NA|NA|NA M Fasciclin OLIIENHM_01386 1440774.Y900_013400 4.2e-86 323.9 Mycobacteriaceae ppiA GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0030312,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0071704,GO:0071944,GO:0140096,GO:1901564 5.2.1.8 ko:K01802,ko:K03767,ko:K03768 ko01503,ko04217,map01503,map04217 ko00000,ko00001,ko01000,ko03110,ko04147 Bacteria 234W3@1762,2IFUE@201174,COG0652@1,COG0652@2 NA|NA|NA O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides OLIIENHM_01387 525368.HMPREF0591_2971 2.1e-46 191.8 Mycobacteriaceae Bacteria 239BR@1762,2ESQF@1,2GRJ0@201174,33K8W@2 NA|NA|NA S Bacterial PH domain OLIIENHM_01388 1440774.Y900_013410 1.8e-41 174.9 Mycobacteriaceae crgA Bacteria 23A12@1762,2B592@1,2HZN5@201174,31Y35@2 NA|NA|NA D cell division OLIIENHM_01389 1440774.Y900_013415 9.6e-100 369.8 Mycobacteriaceae Bacteria 233AR@1762,2GJ9Y@201174,COG3879@1,COG3879@2 NA|NA|NA S Bacterial protein of unknown function (DUF881) OLIIENHM_01390 1440774.Y900_013420 9.6e-105 386.3 Mycobacteriaceae trpG GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 2.6.1.85 ko:K01664,ko:K13950 ko00790,map00790 R01716 RC00010,RC01418 ko00000,ko00001,ko01000 Bacteria 234HI@1762,2GJUX@201174,COG0512@1,COG0512@2 NA|NA|NA EH Anthranilate synthase OLIIENHM_01391 258533.BN977_02797 1.1e-270 939.1 Mycobacteriaceae pknB GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.11.1 ko:K12132 ko00000,ko01000,ko01001 Bacteria 233BZ@1762,2GJ1J@201174,COG0515@1,COG0515@2,COG2815@1,COG2815@2 NA|NA|NA KLT serine threonine protein kinase OLIIENHM_01392 1440774.Y900_013430 5.8e-188 663.7 Mycobacteriaceae Bacteria 232EX@1762,2GMPZ@201174,COG0515@1,COG0515@2 NA|NA|NA KLT serine threonine protein kinase OLIIENHM_01393 931627.MycrhDRAFT_2309 7.7e-237 826.2 Mycobacteriaceae pbpA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 ko:K05364 ko00550,map00550 R04519 RC00005,RC00049 ko00000,ko00001,ko01011 Bacteria 235TI@1762,2GJUQ@201174,COG0768@1,COG0768@2 NA|NA|NA M penicillin-binding protein OLIIENHM_01394 1440774.Y900_013440 8e-215 753.1 Mycobacteriaceae rodA GO:0002682,GO:0002684,GO:0008150,GO:0009605,GO:0009607,GO:0009987,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051301,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0075136 ko:K03588,ko:K05364,ko:K05837 ko00550,ko04112,map00550,map04112 R04519 RC00005,RC00049 ko00000,ko00001,ko01011,ko02000,ko03036 2.A.103.1 Bacteria 232FE@1762,2GJTI@201174,COG0772@1,COG0772@2 NA|NA|NA D Belongs to the SEDS family OLIIENHM_01395 1440774.Y900_013445 1.3e-175 622.9 Mycobacteriaceae pstP GO:0000287,GO:0001932,GO:0001933,GO:0003674,GO:0003824,GO:0004647,GO:0004721,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006469,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009892,GO:0009987,GO:0010563,GO:0010605,GO:0016020,GO:0016021,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019220,GO:0019222,GO:0019538,GO:0030145,GO:0030312,GO:0031224,GO:0031226,GO:0031323,GO:0031324,GO:0031399,GO:0031400,GO:0032268,GO:0032269,GO:0033673,GO:0036211,GO:0042325,GO:0042326,GO:0042578,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043392,GO:0043412,GO:0043549,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0045859,GO:0045936,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051098,GO:0051100,GO:0051101,GO:0051171,GO:0051172,GO:0051174,GO:0051246,GO:0051248,GO:0051338,GO:0051348,GO:0060255,GO:0065007,GO:0065009,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 3.1.3.16 ko:K20074 ko00000,ko01000,ko01009 Bacteria 2341C@1762,2GJ3M@201174,COG0631@1,COG0631@2 NA|NA|NA T PFAM Protein phosphatase 2C OLIIENHM_01396 1440774.Y900_013450 9.9e-69 266.2 Mycobacteriaceae fhaB GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944 Bacteria 232PU@1762,2GKA7@201174,COG1716@1,COG1716@2 NA|NA|NA T FHA domain-containing protein OLIIENHM_01397 1078020.KEK_10878 1.8e-33 147.9 Mycobacteriaceae fhaA GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363 ko:K02283 ko00000,ko02035,ko02044 Bacteria 234GB@1762,2GNU2@201174,COG1716@1,COG1716@2 NA|NA|NA T Fha domain OLIIENHM_01399 931627.MycrhDRAFT_5183 1.8e-240 838.6 Mycobacteriaceae ycfI GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 ko:K06147 ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 2349E@1762,2GITR@201174,COG1132@1,COG1132@2 NA|NA|NA V ABC transporter OLIIENHM_01400 931627.MycrhDRAFT_5182 3.9e-72 277.7 Mycobacteriaceae yabO GO:0008150,GO:0040007 Bacteria 232TW@1762,2H7A9@201174,COG1188@1,COG1188@2 NA|NA|NA J Protein of unknown function (DUF3558) OLIIENHM_01401 1440774.Y900_019840 5.8e-76 290.4 Mycobacteriaceae yabO Bacteria 233JT@1762,2IA90@201174,COG1188@1,COG1188@2 NA|NA|NA J Protein of unknown function (DUF3558) OLIIENHM_01402 525368.HMPREF0591_5216 1.5e-59 235.7 Mycobacteriaceae sixA ko:K08296 ko00000,ko01000 Bacteria 239P1@1762,2GJ0I@201174,COG2062@1,COG2062@2 NA|NA|NA T Phosphohistidine phosphatase SixA OLIIENHM_01403 1440774.Y900_019850 1.1e-156 559.7 Mycobacteriaceae sbcD ko:K03547 ko00000,ko03400 Bacteria 233AC@1762,2HH9X@201174,COG0420@1,COG0420@2 NA|NA|NA L DNA repair exonuclease OLIIENHM_01404 1440774.Y900_019855 1.6e-216 759.6 Mycobacteriaceae GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 ko:K03546 ko00000,ko03400 Bacteria 234HZ@1762,2HU66@201174,COG0419@1,COG0419@2 NA|NA|NA L AAA domain OLIIENHM_01405 1440774.Y900_019865 3.3e-189 667.9 Mycobacteriaceae 2.3.1.20 ko:K00635 ko00561,ko01100,map00561,map01100 M00089 R02251 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 Bacteria 235TY@1762,2GKU0@201174,COG1020@1,COG1020@2 NA|NA|NA Q Diacylglycerol O-acyltransferase OLIIENHM_01406 1440774.Y900_019870 1.8e-144 519.2 Mycobacteriaceae Bacteria 236MV@1762,2HPWG@201174,COG0596@1,COG0596@2 NA|NA|NA S Alpha beta hydrolase OLIIENHM_01407 931627.MycrhDRAFT_5175 4.3e-252 877.1 Mycobacteriaceae oppA GO:0003674,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0017038,GO:0022857,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0033036,GO:0033218,GO:0042277,GO:0042597,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043295,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0048037,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072341,GO:1900750,GO:1901681,GO:1904680 ko:K02035 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 233EQ@1762,2GJ9N@201174,COG0747@1,COG0747@2 NA|NA|NA E extracellular solute-binding OLIIENHM_01408 931627.MycrhDRAFT_5174 7.9e-279 966.1 Mycobacteriaceae oppD GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 ko:K02031,ko:K02032 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 23340@1762,2H3HY@201174,COG1123@1,COG4172@2 NA|NA|NA P Belongs to the ABC transporter superfamily OLIIENHM_01409 1440774.Y900_019885 2.9e-133 481.5 Mycobacteriaceae oppC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02031,ko:K02032,ko:K02034 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 235CB@1762,2GJ9E@201174,COG1173@1,COG1173@2 NA|NA|NA EP transport OLIIENHM_01410 931627.MycrhDRAFT_5172 4.5e-156 557.4 Mycobacteriaceae oppB GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 ko:K02033 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 232X5@1762,2GJ2C@201174,COG0601@1,COG0601@2 NA|NA|NA EP transport OLIIENHM_01412 1150599.MPHLEI_06227 2.4e-81 308.1 Mycobacteriaceae cah GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008270,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0040007,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0071944 4.2.1.1 ko:K01673 ko00910,map00910 R00132,R10092 RC02807 ko00000,ko00001,ko01000 Bacteria 2358R@1762,2GM1M@201174,COG0288@1,COG0288@2 NA|NA|NA P reversible hydration of carbon dioxide OLIIENHM_01413 931627.MycrhDRAFT_5169 2.2e-160 571.6 Mycobacteriaceae cysD GO:0000103,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009336,GO:0009605,GO:0009987,GO:0009991,GO:0010134,GO:0010438,GO:0019419,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0033554,GO:0034599,GO:0040007,GO:0042221,GO:0042594,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0061695,GO:0070887,GO:0071496,GO:1902494,GO:1902503,GO:1990234 1.8.4.10,1.8.4.8,2.7.7.4 ko:K00390,ko:K00957 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R02021,R04929 RC00007,RC02809,RC02862,RC02889 ko00000,ko00001,ko00002,ko01000 Bacteria 232AT@1762,2GN85@201174,COG0175@1,COG0175@2 NA|NA|NA H Sulfate adenylyltransferase subunit 2 OLIIENHM_01414 1440774.Y900_019900 0.0 1092.8 Mycobacteriaceae cysC GO:0000103,GO:0003674,GO:0003824,GO:0004020,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006790,GO:0006793,GO:0006796,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009336,GO:0009605,GO:0009987,GO:0009991,GO:0010134,GO:0010438,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019419,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0033554,GO:0034599,GO:0040007,GO:0042221,GO:0042594,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0061695,GO:0070887,GO:0071496,GO:0071944,GO:1902494,GO:1902503,GO:1990234 2.7.1.25,2.7.7.4 ko:K00860,ko:K00955,ko:K00956 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00509,R00529,R04928,R04929 RC00002,RC00078,RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 Bacteria 232JD@1762,2GJDX@201174,COG0529@1,COG0529@2,COG2895@1,COG2895@2 NA|NA|NA P Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily OLIIENHM_01415 1041522.MCOL_V206340 5.1e-104 384.0 Mycobacteriaceae cysQ 3.1.3.7 ko:K01082 ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130 R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03016 Bacteria 233VA@1762,2GMW7@201174,COG1218@1,COG1218@2 NA|NA|NA P PFAM inositol monophosphatase OLIIENHM_01416 931627.MycrhDRAFT_5164 6.2e-49 201.8 Mycobacteriaceae Bacteria 23CSQ@1762,2B6RK@1,2H2H1@201174,31ZQJ@2 NA|NA|NA OLIIENHM_01417 931627.MycrhDRAFT_5164 3.9e-19 102.8 Mycobacteriaceae Bacteria 23CSQ@1762,2B6RK@1,2H2H1@201174,31ZQJ@2 NA|NA|NA OLIIENHM_01418 931627.MycrhDRAFT_5163 4.8e-19 102.4 Mycobacteriaceae Bacteria 23CXK@1762,2B79P@1,2H3YV@201174,320CJ@2 NA|NA|NA OLIIENHM_01419 1298864.AUEQ01000008_gene2605 3.3e-67 261.2 Mycobacteriaceae iscR 2.8.1.7 ko:K04487,ko:K13643 ko00730,ko01100,ko04122,map00730,map01100,map04122 R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03000,ko03016,ko03029 Bacteria 238N2@1762,2INF3@201174,COG1959@1,COG1959@2 NA|NA|NA K Transcriptional regulator OLIIENHM_01420 1440774.Y900_019935 1.8e-164 585.5 Mycobacteriaceae tdt Bacteria 2357X@1762,2GKPA@201174,COG1275@1,COG1275@2 NA|NA|NA P C4-dicarboxylate transporter malic acid transport protein OLIIENHM_01421 1078020.KEK_06518 3e-130 471.5 Mycobacteriaceae Bacteria 233F9@1762,2HVKH@201174,COG2141@1,COG2141@2 NA|NA|NA C Luciferase-like monooxygenase OLIIENHM_01422 931627.MycrhDRAFT_5157 8.4e-194 682.9 Mycobacteriaceae 1.13.12.4 ko:K00467 ko00620,map00620 R00319 RC01312 ko00000,ko00001,ko01000 Bacteria 2342A@1762,2GJA5@201174,COG1304@1,COG1304@2 NA|NA|NA C COG1304 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases OLIIENHM_01423 931627.MycrhDRAFT_5156 1.4e-90 339.3 Mycobacteriaceae ko:K07005 ko00000 Bacteria 232UM@1762,2GJ76@201174,COG3467@1,COG3467@2 NA|NA|NA S Pyridoxamine 5'-phosphate oxidase OLIIENHM_01426 350058.Mvan_1146 5.9e-145 520.4 Mycobacteriaceae Bacteria 237MW@1762,2H3MV@201174,COG1061@1,COG1061@2,COG1112@1,COG1112@2 NA|NA|NA KL DNA helicase OLIIENHM_01427 1440774.Y900_017515 4.2e-22 110.9 Mycobacteriaceae Bacteria 239YS@1762,2FC6U@1,2IPAS@201174,344AN@2 NA|NA|NA OLIIENHM_01428 931627.MycrhDRAFT_3418 3e-187 661.4 Mycobacteriaceae deaD 3.6.4.13 ko:K05592,ko:K11927 ko03018,map03018 ko00000,ko00001,ko01000,ko03009,ko03019 Bacteria 2351D@1762,2GIUR@201174,COG0513@1,COG0513@2 NA|NA|NA L DEAD DEAH box helicase OLIIENHM_01429 931627.MycrhDRAFT_3426 1.2e-148 533.1 Mycobacteriaceae lppS Bacteria 23D9P@1762,2GJBA@201174,COG1376@1,COG1376@2 NA|NA|NA S L,D-transpeptidase catalytic domain OLIIENHM_01431 1122247.C731_4702 6.6e-107 394.0 Mycobacteriaceae apaH 3.1.3.16 ko:K01090,ko:K07313 ko00000,ko01000 Bacteria 236X8@1762,2GMB5@201174,COG0639@1,COG0639@2 NA|NA|NA T Calcineurin-like phosphoesterase OLIIENHM_01432 525368.HMPREF0591_6434 1.8e-169 602.4 Mycobacteriaceae agcS ko:K03310 ko00000 2.A.25 Bacteria 236HG@1762,2GIU2@201174,COG1115@1,COG1115@2 NA|NA|NA E amino acid carrier protein OLIIENHM_01433 525368.HMPREF0591_2162 9.7e-137 493.0 Mycobacteriaceae dhmA GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 3.8.1.5 ko:K01563 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 R05284,R05367,R05368,R05369,R05370,R07669,R07670 RC01317,RC01340,RC01341,RC02013 ko00000,ko00001,ko01000 Bacteria 23F6M@1762,2GKJB@201174,COG0596@1,COG0596@2 NA|NA|NA S Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons OLIIENHM_01434 1120797.KB908273_gene2333 1.1e-43 182.6 Mycobacteriaceae Bacteria 23A9M@1762,2DQ16@1,2IMJY@201174,334AZ@2 NA|NA|NA S SpoIIAA-like OLIIENHM_01435 1380386.JIAW01000023_gene6625 1.1e-19 103.2 Mycobacteriaceae Bacteria 23BS0@1762,28Q5A@1,2GQGX@201174,31SAX@2 NA|NA|NA OLIIENHM_01436 1111729.ATYV01000011_gene385 1.4e-34 152.1 Corynebacteriaceae rpsN GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02954 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 22NID@1653,2IKN9@201174,COG0199@1,COG0199@2 NA|NA|NA J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site OLIIENHM_01437 1150599.MPHLEI_17342 7.8e-21 105.5 Mycobacteriaceae rpmG GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046677,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02913 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 23BAB@1762,2GQFV@201174,COG0267@1,COG0267@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL33 family OLIIENHM_01438 487521.OCU_47760 2.4e-31 141.0 Mycobacteriaceae rpmB GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02902 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 23AS9@1762,2IQAT@201174,COG0227@1,COG0227@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL28 family OLIIENHM_01439 1380386.JIAW01000023_gene6620 1.8e-143 515.8 Mycobacteriaceae Bacteria 2337F@1762,2GKDR@201174,COG0523@1,COG0523@2 NA|NA|NA S cobalamin synthesis CobW domain protein OLIIENHM_01440 262316.MAP_3771 1.9e-30 138.3 Mycobacteriaceae rpmE2 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0033554,GO:0034224,GO:0034641,GO:0034645,GO:0042594,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0120127,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02909 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 23AMH@1762,2IQ4I@201174,COG0254@1,COG0254@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL31 family OLIIENHM_01441 1172188.KB911831_gene4001 2.7e-12 77.8 Intrasporangiaceae Bacteria 29UUF@1,2HY1U@201174,30G6Y@2,4FJDS@85021 NA|NA|NA OLIIENHM_01442 931627.MycrhDRAFT_3432 6.3e-96 357.1 Mycobacteriaceae echA3 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 Bacteria 232DT@1762,2I8WN@201174,COG1024@1,COG1024@2 NA|NA|NA I Enoyl-CoA hydratase OLIIENHM_01443 164757.Mjls_5754 1.2e-59 238.4 Mycobacteriaceae pilY1 ko:K02674 ko00000,ko02035,ko02044 Bacteria 236JM@1762,2IAZN@201174,COG2304@1,COG2304@2 NA|NA|NA S Pkd domain containing protein OLIIENHM_01444 1440774.Y900_017680 9.3e-119 433.0 Mycobacteriaceae pksB GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006090,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019184,GO:0019752,GO:0031974,GO:0032787,GO:0034641,GO:0042398,GO:0043043,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0051186,GO:0051188,GO:0070013,GO:0071704,GO:1901564,GO:1901566,GO:1901576 3.1.2.6 ko:K01069 ko00620,map00620 R01736 RC00004,RC00137 ko00000,ko00001,ko01000 Bacteria 2344Z@1762,2GNS6@201174,COG0491@1,COG0491@2 NA|NA|NA S Metallo-beta-lactamase superfamily OLIIENHM_01448 1440774.Y900_017740 2.5e-82 312.4 Mycobacteriaceae Bacteria 2375C@1762,2GKXC@201174,COG3021@1,COG3021@2 NA|NA|NA S Endonuclease Exonuclease phosphatase OLIIENHM_01449 931627.MycrhDRAFT_3450 2.7e-51 208.4 Mycobacteriaceae 3.1.3.48 ko:K01104 ko00000,ko01000 Bacteria 239QN@1762,2GMPR@201174,COG0394@1,COG0394@2 NA|NA|NA T Low molecular weight phosphotyrosine protein phosphatase OLIIENHM_01452 1150599.MPHLEI_10479 1.2e-24 118.2 Mycobacteriaceae rpmG ko:K02913 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 23B7J@1762,2GQFG@201174,COG0267@1,COG0267@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL33 family OLIIENHM_01453 1440774.Y900_017700 2.3e-57 228.4 Mycobacteriaceae GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0019171,GO:0040007,GO:0044464,GO:0071944 Bacteria 238US@1762,2GMVC@201174,COG2030@1,COG2030@2 NA|NA|NA I Belongs to the UPF0336 family OLIIENHM_01454 318424.EU78_05165 2e-66 258.5 Mycobacteriaceae hadB Bacteria 238KF@1762,2IFCJ@201174,COG2030@1,COG2030@2 NA|NA|NA I Functions as a heterodimer along with HadA or HadC in fatty acid biosynthesis OLIIENHM_01455 1440774.Y900_017710 7.3e-73 280.0 Mycobacteriaceae GO:0001676,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019171,GO:0019752,GO:0030497,GO:0032787,GO:0042759,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:0072330,GO:1901576 Bacteria 234YP@1762,2GMVC@201174,COG2030@1,COG2030@2 NA|NA|NA I Belongs to the UPF0336 family OLIIENHM_01457 1440774.Y900_017720 2.6e-36 158.3 Mycobacteriaceae secE GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K03073 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 Bacteria 23AFD@1762,2GQFP@201174,COG0690@1,COG0690@2 NA|NA|NA U Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation OLIIENHM_01458 1209984.BN978_06834 1.3e-126 459.1 Mycobacteriaceae yebC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 Bacteria 234A2@1762,2GJ4G@201174,COG0217@1,COG0217@2 NA|NA|NA K transcriptional regulatory protein OLIIENHM_01459 350058.Mvan_2572 3.2e-13 81.3 Mycobacteriaceae Bacteria 23AQ8@1762,2AB0D@1,2IRCN@201174,32BPI@2 NA|NA|NA OLIIENHM_01460 931627.MycrhDRAFT_4780 9.7e-88 329.7 Mycobacteriaceae ruvC GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 ko:K01159 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 2330I@1762,2GJI5@201174,COG0817@1,COG0817@2 NA|NA|NA L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group OLIIENHM_01461 258533.BN977_06035 2.6e-82 311.6 Mycobacteriaceae ruvA GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 ko:K03550 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 236D6@1762,2GN17@201174,COG0632@1,COG0632@2 NA|NA|NA L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB OLIIENHM_01462 1440774.Y900_001745 9.2e-179 632.9 Mycobacteriaceae ruvB GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 3.6.4.12 ko:K03551 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 233UV@1762,2GJZF@201174,COG2255@1,COG2255@2 NA|NA|NA L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing OLIIENHM_01463 47839.CCAU010000008_gene2112 3.9e-39 167.5 Mycobacteriaceae ko:K08987 ko00000 Bacteria 23A3Y@1762,2IRV5@201174,COG3759@1,COG3759@2 NA|NA|NA S Protein of unknown function (DUF1304) OLIIENHM_01464 1440774.Y900_001725 6e-61 240.7 Mycobacteriaceae Bacteria 238JW@1762,2CAD5@1,2IAVC@201174,32Z7A@2 NA|NA|NA OLIIENHM_01465 1150599.MPHLEI_20129 4e-238 830.5 Mycobacteriaceae prr1 1.2.1.8 ko:K00130 ko00260,ko01100,map00260,map01100 M00555 R02565,R02566 RC00080 ko00000,ko00001,ko00002,ko01000 Bacteria 232XE@1762,2GIWZ@201174,COG1012@1,COG1012@2 NA|NA|NA C Belongs to the aldehyde dehydrogenase family OLIIENHM_01466 931627.MycrhDRAFT_4792 1.4e-221 775.4 Mycobacteriaceae gabT GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.6.1.19,2.6.1.22 ko:K00823,ko:K07250 ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648,R04188 RC00006,RC00062,RC00160 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 232MK@1762,2GIS9@201174,COG0160@1,COG0160@2 NA|NA|NA E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family OLIIENHM_01467 1440774.Y900_001705 4.4e-79 301.2 Mycobacteriaceae Bacteria 2349B@1762,2GKG5@201174,COG0778@1,COG0778@2 NA|NA|NA C nitroreductase OLIIENHM_01468 1440774.Y900_001700 9.1e-40 169.5 Mycobacteriaceae yajC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 Bacteria 239XH@1762,2HI0T@201174,COG1862@1,COG1862@2 NA|NA|NA U Preprotein translocase OLIIENHM_01469 931627.MycrhDRAFT_1457 4.3e-86 323.9 Mycobacteriaceae menB GO:0003674,GO:0003824,GO:0005488,GO:0006732,GO:0008150,GO:0008152,GO:0008935,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0042180,GO:0042181,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:0071890,GO:1901576,GO:1901661,GO:1901663 4.1.3.36 ko:K01661 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R07263 RC01923 ko00000,ko00001,ko00002,ko01000 Bacteria 232FW@1762,2GK5G@201174,COG0447@1,COG0447@2 NA|NA|NA H Belongs to the enoyl-CoA hydratase isomerase family. MenB subfamily OLIIENHM_01470 1043205.AFYF01000006_gene1475 6.1e-59 234.2 Intrasporangiaceae Bacteria 2HJGE@201174,4FGMX@85021,COG0300@1,COG0300@2 NA|NA|NA S Enoyl-(Acyl carrier protein) reductase OLIIENHM_01471 551275.KB899546_gene2299 2.5e-48 199.5 Bacteria Bacteria COG0683@1,COG0683@2 NA|NA|NA E ABC-type branched-chain amino acid transport systems, periplasmic component OLIIENHM_01472 931627.MycrhDRAFT_4679 5.6e-151 540.8 Mycobacteriaceae Bacteria 236IQ@1762,2I9JX@201174,COG3174@1,COG3174@2 NA|NA|NA S Domain of unknown function (DUF4010) OLIIENHM_01473 557599.MKAN_22315 1.3e-29 135.2 Mycobacteriaceae bnzC Bacteria 232J6@1762,2GM8H@201174,COG0346@1,COG0346@2 NA|NA|NA E PFAM Glyoxalase bleomycin resistance protein dioxygenase OLIIENHM_01475 350058.Mvan_1080 1.2e-268 932.2 Actinobacteria 6.1.3.1 ko:K22319 ko00000,ko01000 Bacteria 2GJR0@201174,COG0318@1,COG0318@2 NA|NA|NA IQ synthetase OLIIENHM_01476 350058.Mvan_1079 2.7e-133 481.5 Mycobacteriaceae Bacteria 23ABM@1762,2HEN1@201174,COG0596@1,COG0596@2 NA|NA|NA S Serine aminopeptidase, S33 OLIIENHM_01477 526218.Sterm_0333 5.3e-146 524.6 Bacteria Bacteria COG1520@1,COG1520@2 NA|NA|NA S amino acid activation for nonribosomal peptide biosynthetic process OLIIENHM_01478 525368.HMPREF0591_4316 1.7e-95 355.9 Mycobacteriaceae Bacteria 233G6@1762,2DMG6@1,2GMQI@201174,32RB5@2 NA|NA|NA S MDMPI C-terminal domain OLIIENHM_01479 1440774.Y900_005440 1.1e-90 339.7 Mycobacteriaceae Bacteria 233AP@1762,2GM50@201174,COG0697@1,COG0697@2 NA|NA|NA EG EamA-like transporter family OLIIENHM_01480 931627.MycrhDRAFT_1401 1.3e-72 279.3 Mycobacteriaceae smpB GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0070930,GO:0071704,GO:0097159,GO:1901363,GO:1901564 ko:K03664 ko00000 Bacteria 2339Z@1762,2GJX1@201174,COG0691@1,COG0691@2 NA|NA|NA J Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene OLIIENHM_01481 1440774.Y900_005450 5.8e-134 483.8 Mycobacteriaceae ftsX GO:0000910,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0007154,GO:0007165,GO:0007166,GO:0008150,GO:0008356,GO:0009274,GO:0009276,GO:0009966,GO:0009987,GO:0010033,GO:0010646,GO:0016020,GO:0016021,GO:0016043,GO:0019221,GO:0022402,GO:0022603,GO:0022607,GO:0023051,GO:0023052,GO:0030312,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0032153,GO:0032506,GO:0034097,GO:0040007,GO:0042173,GO:0042221,GO:0043937,GO:0043938,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051301,GO:0051716,GO:0065007,GO:0070098,GO:0070297,GO:0070887,GO:0071310,GO:0071345,GO:0071840,GO:0071944,GO:0090529,GO:1902531 ko:K09811,ko:K09812 ko02010,map02010 M00256 ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 Bacteria 234IC@1762,2GJMA@201174,COG2177@1,COG2177@2 NA|NA|NA D Part of the ABC transporter FtsEX involved in cellular division OLIIENHM_01482 1370120.AUWR01000036_gene2043 1.8e-114 418.7 Mycobacteriaceae ftsE GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019897,GO:0019898,GO:0030145,GO:0030554,GO:0031234,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363 ko:K09811,ko:K09812 ko02010,map02010 M00256 ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 Bacteria 233M6@1762,2GJE1@201174,COG2884@1,COG2884@2 NA|NA|NA D cell division ATP-binding protein FtsE OLIIENHM_01483 1370125.AUWT01000004_gene3405 4.2e-19 101.3 Mycobacteriaceae Bacteria 239GG@1762,2ATJE@1,2IIUQ@201174,31J3G@2 NA|NA|NA OLIIENHM_01484 931627.MycrhDRAFT_1397 8.4e-131 473.4 Mycobacteriaceae mscS ko:K22044 ko00000,ko02000 1.A.23.3 Bacteria 233ER@1762,2GMFK@201174,COG0668@1,COG0668@2 NA|NA|NA M mechanosensitive ion channel OLIIENHM_01485 710686.Mycsm_01571 1e-188 666.0 Mycobacteriaceae prfB GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944 2.1.1.80,3.1.1.61 ko:K02835,ko:K02836,ko:K02839,ko:K13924 ko02020,ko02030,map02020,map02030 M00506 ko00000,ko00001,ko00002,ko01000,ko02022,ko02035,ko03012 Bacteria 234K9@1762,2I7Z5@201174,COG0216@1,COG0216@2 NA|NA|NA J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA OLIIENHM_01486 710685.MycrhN_0222 2.1e-191 675.2 Mycobacteriaceae fprA GO:0000166,GO:0003674,GO:0003824,GO:0004324,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0008860,GO:0016491,GO:0016730,GO:0016731,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0055114,GO:0070401,GO:0071944,GO:0097159,GO:1901265,GO:1901363 1.18.1.2,1.19.1.1 ko:K00528 R10159 ko00000,ko01000 Bacteria 235GB@1762,2GJ4A@201174,COG0493@1,COG0493@2 NA|NA|NA E oxidoreductase OLIIENHM_01487 931627.MycrhDRAFT_1390 7.8e-41 172.9 Mycobacteriaceae Bacteria 23A85@1762,2B18P@1,2IM8S@201174,31TP4@2 NA|NA|NA OLIIENHM_01488 931627.MycrhDRAFT_1389 5.4e-115 420.6 Mycobacteriaceae hisN GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008934,GO:0009058,GO:0009987,GO:0010125,GO:0010126,GO:0016020,GO:0016053,GO:0016137,GO:0016138,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042578,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0052745,GO:0052803,GO:0052834,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901657,GO:1901659 3.1.3.15 ko:K05602 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013 RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 234QJ@1762,2GKZZ@201174,COG0483@1,COG0483@2 NA|NA|NA G Inositol monophosphatase OLIIENHM_01489 1440774.Y900_005510 4.3e-213 747.3 Mycobacteriaceae fadE24 Bacteria 234QF@1762,2GJH2@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_01490 1440774.Y900_005515 2.6e-201 708.0 Mycobacteriaceae fadE23 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 Bacteria 232QR@1762,2GNBW@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_01491 1172186.KB911469_gene2611 5.7e-153 547.0 Mycobacteriaceae fbpB 2.3.1.122,2.3.1.20 ko:K18851 ko00561,ko01100,map00561,map01100 M00089 R02251 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 Bacteria 232KQ@1762,2GJX4@201174,COG0627@1,COG0627@2 NA|NA|NA S fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan, and through the synthesis of alpha,alpha-trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) to another TMM, leading to the formation of TDM OLIIENHM_01492 1440774.Y900_005600 7e-185 653.3 Mycobacteriaceae hmgA GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114 1.13.11.5 ko:K00451 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R02519 RC00737 ko00000,ko00001,ko00002,ko01000 Bacteria 235XH@1762,2GKZV@201174,COG3508@1,COG3508@2 NA|NA|NA Q Homogentisate 1,2-dioxygenase OLIIENHM_01493 1440774.Y900_005605 1.9e-193 681.8 Mycobacteriaceae Bacteria 234ND@1762,2GNCI@201174,COG1073@1,COG1073@2 NA|NA|NA S Alpha beta hydrolase OLIIENHM_01494 164757.Mjls_1559 5.4e-196 690.3 Mycobacteriaceae 2.8.3.16 ko:K07749 ko00000,ko01000 Bacteria 235M1@1762,2GIU7@201174,COG1804@1,COG1804@2 NA|NA|NA C acyl-CoA transferases carnitine dehydratase OLIIENHM_01495 1440774.Y900_005615 2.3e-130 471.9 Mycobacteriaceae mvaB 4.1.3.4 ko:K01640 ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146 M00036,M00088 R01360,R08090 RC00502,RC00503,RC01118,RC01946 ko00000,ko00001,ko00002,ko01000 Bacteria 235HR@1762,2GKTP@201174,COG0119@1,COG0119@2 NA|NA|NA E Isopropylmalate homocitrate citramalate OLIIENHM_01496 931627.MycrhDRAFT_1363 1.6e-227 795.0 Mycobacteriaceae MA20_16360 1.3.8.1,1.3.8.7 ko:K00248,ko:K00249 ko00071,ko00280,ko00410,ko00640,ko00650,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map00650,map01100,map01110,map01120,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01178,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00120,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 Bacteria 2357V@1762,2GJX5@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_01497 931627.MycrhDRAFT_1362 7.1e-130 470.3 Mycobacteriaceae MA20_16375 Bacteria 233GC@1762,2HU7E@201174,COG3173@1,COG3173@2 NA|NA|NA S Aminoglycoside phosphotransferase OLIIENHM_01498 557599.MKAN_22240 4.9e-36 157.1 Mycobacteriaceae Bacteria 23AJ7@1762,2IQRM@201174,COG3173@1,COG3173@2 NA|NA|NA S Aminoglycoside phosphotransferase OLIIENHM_01499 1440774.Y900_005655 5.6e-44 184.1 Mycobacteriaceae Bacteria 23EWW@1762,2IFEK@201174,COG2353@1,COG2353@2 NA|NA|NA S Belongs to the UPF0312 family OLIIENHM_01500 1122247.C731_1431 2.3e-55 221.5 Mycobacteriaceae GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 Bacteria 239F2@1762,2II71@201174,COG0784@1,COG0784@2 NA|NA|NA T response regulator OLIIENHM_01501 931627.MycrhDRAFT_1357 3.9e-49 200.7 Mycobacteriaceae nuoA GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044464,GO:0050136,GO:0055114,GO:0071944,GO:0098796,GO:1902494 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 239AP@1762,2IKWT@201174,COG0838@1,COG0838@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient OLIIENHM_01502 258533.BN977_05143 2.7e-94 351.3 Mycobacteriaceae nuoB 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 23482@1762,2GJXR@201174,COG0377@1,COG0377@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient OLIIENHM_01503 931627.MycrhDRAFT_1355 7.1e-111 406.8 Mycobacteriaceae nuoC GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0050136,GO:0055114 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 233V0@1762,2GIRH@201174,COG0852@1,COG0852@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient OLIIENHM_01504 931627.MycrhDRAFT_1354 9.3e-234 815.8 Mycobacteriaceae nuoD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 232DN@1762,2GKEZ@201174,COG0649@1,COG0649@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient OLIIENHM_01505 931627.MycrhDRAFT_4563 5e-40 170.6 Mycobacteriaceae ko:K18481 M00670 ko00000,ko00002,ko02000 3.A.1.27.4,3.A.1.27.5 Bacteria 23644@1762,2E5BU@1,2GQEF@201174,343EN@2 NA|NA|NA OLIIENHM_01506 931627.MycrhDRAFT_4627 1e-300 1038.9 Mycobacteriaceae acsA 6.2.1.1,6.2.1.16 ko:K01895,ko:K01907 ko00010,ko00280,ko00620,ko00640,ko00650,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00280,map00620,map00640,map00650,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354,R01357 RC00004,RC00012,RC00014,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 235UW@1762,2GM20@201174,COG0365@1,COG0365@2 NA|NA|NA I TIGRFAM Acetoacetyl-CoA synthase OLIIENHM_01507 931627.MycrhDRAFT_4634 4.4e-101 374.4 Mycobacteriaceae ko:K07124 ko00000 Bacteria 2358U@1762,2I2R6@201174,COG0300@1,COG0300@2 NA|NA|NA S Belongs to the short-chain dehydrogenases reductases (SDR) family OLIIENHM_01508 1440774.Y900_020460 6.9e-14 83.2 Mycobacteriaceae Bacteria 23ECR@1762,2B8SA@1,2H7H3@201174,322ZK@2 NA|NA|NA OLIIENHM_01509 1157943.KB892705_gene3518 1.5e-24 119.4 Mycobacteriaceae Bacteria 23AU6@1762,2ATIH@1,2IG7X@201174,31H41@2 NA|NA|NA OLIIENHM_01510 931627.MycrhDRAFT_6809 7.4e-23 114.0 Mycobacteriaceae Bacteria 238X6@1762,2ASCD@1,2IH3B@201174,31HRN@2 NA|NA|NA OLIIENHM_01511 931627.MycrhDRAFT_6813 0.0 1221.5 Mycobacteriaceae ko:K07027 ko00000,ko02000 4.D.2 Bacteria 234XJ@1762,2GMAV@201174,COG0392@1,COG0392@2 NA|NA|NA T integral membrane protein OLIIENHM_01512 471852.Tcur_0776 3.5e-63 248.4 Actinobacteria Bacteria 2GNM4@201174,COG1028@1,COG1028@2 NA|NA|NA IQ Short-chain dehydrogenase reductase sdr OLIIENHM_01513 596153.Alide_2444 7.6e-20 105.1 Comamonadaceae 3.1.4.17 ko:K01120 ko00230,map00230 R00191,R01234 RC00296 ko00000,ko00001,ko01000 Bacteria 1MV37@1224,2VJ21@28216,4AABZ@80864,COG2203@1,COG2203@2,COG2206@1,COG2206@2 NA|NA|NA T GAF domain OLIIENHM_01514 1223521.BBJX01000005_gene2111 1.4e-13 80.9 Comamonadaceae argA GO:0003674,GO:0003824,GO:0003991,GO:0004042,GO:0004358,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016407,GO:0016410,GO:0016597,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.7.2.8 ko:K00619,ko:K00930,ko:K14682 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02649 RC00002,RC00004,RC00043,RC00064 ko00000,ko00001,ko00002,ko01000 iECP_1309.ECP_2830,iLF82_1304.LF82_0116,iNRG857_1313.NRG857_13920,iYL1228.KPN_03226 Bacteria 1MUUP@1224,2VGZC@28216,4AACM@80864,COG0548@1,COG0548@2,COG1246@1,COG1246@2 NA|NA|NA E Belongs to the acetyltransferase family. ArgA subfamily OLIIENHM_01515 710421.Mycch_0430 4.9e-70 270.8 Mycobacteriaceae Bacteria 233FQ@1762,2GNQY@201174,COG4833@1,COG4833@2 NA|NA|NA G hydrolase, family 76 OLIIENHM_01516 1341646.CBMO010000153_gene6420 4.7e-54 218.0 Mycobacteriaceae Bacteria 23CGI@1762,2FK6M@1,2H37E@201174,3200A@2 NA|NA|NA S Probable lipoprotein LpqN OLIIENHM_01517 931627.MycrhDRAFT_2984 6.8e-21 106.7 Mycobacteriaceae Bacteria 23EIS@1762,2BSSZ@1,2HDGB@201174,32MWC@2 NA|NA|NA OLIIENHM_01518 216594.MMAR_0668 9e-84 316.6 Mycobacteriaceae dedA ko:K03975 ko00000 Bacteria 233VH@1762,2GKGR@201174,COG0586@1,COG0586@2 NA|NA|NA S membrane-associated protein OLIIENHM_01519 710421.Mycch_0434 1.4e-176 625.5 Mycobacteriaceae fbaA GO:0003674,GO:0003824,GO:0004332,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016830,GO:0016832,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035375,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 iZ_1308.Z4263 Bacteria 233VE@1762,2GM5P@201174,COG0191@1,COG0191@2 NA|NA|NA G fructose-bisphosphate aldolase OLIIENHM_01520 1440774.Y900_015855 6.6e-59 234.2 Mycobacteriaceae dacC 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 ko00000,ko00001,ko01000,ko01002,ko01011 Bacteria 233FV@1762,2GMGK@201174,COG3115@1,COG3115@2 NA|NA|NA D cell septum assembly OLIIENHM_01521 1440774.Y900_015860 7.3e-63 246.5 Mycobacteriaceae Bacteria 238M1@1762,2DMMI@1,2IKP6@201174,32SFN@2 NA|NA|NA S Protein of unknown function (DUF3151) OLIIENHM_01522 1440774.Y900_015870 3.5e-107 394.8 Mycobacteriaceae czcD ko:K16264 ko00000,ko02000 2.A.4.1 Bacteria 232X1@1762,2GMRZ@201174,COG1230@1,COG1230@2 NA|NA|NA P cation diffusion facilitator family transporter OLIIENHM_01523 1440774.Y900_015875 4.3e-117 427.6 Mycobacteriaceae Bacteria 233KC@1762,2GM8E@201174,COG1994@1,COG1994@2 NA|NA|NA S Peptidase M50 OLIIENHM_01524 350058.Mvan_0675 1.3e-185 656.0 Mycobacteriaceae cyp137 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0008150,GO:0008152,GO:0008202,GO:0016020,GO:0016125,GO:0016491,GO:0044238,GO:0044464,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901615 1.14.14.1 ko:K00493 ko00071,ko00380,ko00627,ko01120,map00071,map00380,map00627,map01120 R03629,R04121,R05259 RC00046,RC01311 ko00000,ko00001,ko01000 Bacteria 2331U@1762,2GK4Z@201174,COG2124@1,COG2124@2 NA|NA|NA C cytochrome p450 OLIIENHM_01526 164757.Mjls_0503 3.6e-58 231.5 Mycobacteriaceae Bacteria 237G6@1762,2IFXY@201174,COG1597@1,COG1597@2 NA|NA|NA I lipid kinase activity OLIIENHM_01527 1120797.KB908264_gene3736 0.0 1426.0 Mycobacteriaceae yaaO 4.1.1.19 ko:K01584,ko:K01585 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 Bacteria 2361F@1762,2GJ31@201174,COG1982@1,COG1982@2 NA|NA|NA E Orn Lys Arg decarboxylase OLIIENHM_01528 710685.MycrhN_0719 1.4e-108 399.4 Mycobacteriaceae uspA4 GO:0008150,GO:0040007 Bacteria 2345H@1762,2I8XM@201174,COG0589@1,COG0589@2 NA|NA|NA T Universal stress protein OLIIENHM_01529 216594.MMAR_2407 1e-201 709.5 Mycobacteriaceae ko:K03294 ko00000 2.A.3.2 Bacteria 23292@1762,2GJ75@201174,COG0531@1,COG0531@2 NA|NA|NA E amino acid OLIIENHM_01530 931627.MycrhDRAFT_3519 5.4e-164 583.9 Mycobacteriaceae GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005758,GO:0005829,GO:0006323,GO:0006915,GO:0006919,GO:0006950,GO:0006996,GO:0007005,GO:0007154,GO:0007165,GO:0007275,GO:0007399,GO:0008150,GO:0008152,GO:0008219,GO:0009893,GO:0009987,GO:0010257,GO:0010604,GO:0010941,GO:0010942,GO:0010950,GO:0010952,GO:0012501,GO:0016020,GO:0016043,GO:0016174,GO:0016491,GO:0016651,GO:0019222,GO:0019866,GO:0022008,GO:0022607,GO:0023052,GO:0030154,GO:0030162,GO:0030182,GO:0030261,GO:0031090,GO:0031323,GO:0031325,GO:0031966,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0032268,GO:0032270,GO:0032501,GO:0032502,GO:0032981,GO:0033108,GO:0033554,GO:0034622,GO:0034976,GO:0035556,GO:0042981,GO:0043065,GO:0043067,GO:0043068,GO:0043085,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043280,GO:0043281,GO:0043933,GO:0044085,GO:0044093,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045862,GO:0048471,GO:0048518,GO:0048522,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0050664,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051276,GO:0051336,GO:0051345,GO:0051716,GO:0052547,GO:0052548,GO:0055114,GO:0060255,GO:0065003,GO:0065007,GO:0065009,GO:0070013,GO:0070059,GO:0071103,GO:0071840,GO:0080090,GO:0097190,GO:0097193,GO:2000116,GO:2001056 1.18.1.3,1.7.1.15 ko:K00362,ko:K00529 ko00071,ko00360,ko00910,ko01120,ko01220,map00071,map00360,map00910,map01120,map01220 M00530,M00545 R00787,R02000,R06782,R06783 RC00098,RC00176 br01602,ko00000,ko00001,ko00002,ko01000 Bacteria 2339N@1762,2GJKT@201174,COG0446@1,COG0446@2 NA|NA|NA S Pyridine nucleotide-disulphide oxidoreductase OLIIENHM_01531 931627.MycrhDRAFT_3522 1.6e-71 275.8 Mycobacteriaceae mftR GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141 Bacteria 234FY@1762,2HFWX@201174,COG1309@1,COG1309@2 NA|NA|NA K Transcriptional regulator OLIIENHM_01533 710685.MycrhN_0709 2e-32 144.8 Mycobacteriaceae mftB ko:K06139 ko00000 Bacteria 23A01@1762,2GQQT@201174,COG0535@1,COG0535@2 NA|NA|NA S Mycofactocin system OLIIENHM_01534 1440774.Y900_018065 1.5e-195 688.7 Mycobacteriaceae pqqE GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 235P4@1762,2GNSY@201174,COG0535@1,COG0535@2 NA|NA|NA C Radical SAM OLIIENHM_01535 931627.MycrhDRAFT_3526 4.8e-192 677.2 Mycobacteriaceae lldD1 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.1.2.3,1.1.3.15 ko:K00101,ko:K00104 ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130 R00196,R00475 RC00042,RC00044 ko00000,ko00001,ko01000 iNJ661.Rv0694 Bacteria 233AN@1762,2GJA5@201174,COG1304@1,COG1304@2 NA|NA|NA C Dehydrogenase OLIIENHM_01536 262316.MAP_4155 1.1e-82 313.2 Mycobacteriaceae mftE 3.5.2.10 ko:K01470 ko00330,map00330 R01884 RC00615 ko00000,ko00001,ko01000 Bacteria 2359K@1762,2HCRK@201174,COG1402@1,COG1402@2 NA|NA|NA S creatinine amidohydrolase family protein OLIIENHM_01537 164757.Mjls_2504 8.8e-159 566.2 Mycobacteriaceae pafA GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170 6.3.1.19 ko:K13571 M00342 R11207 RC00090,RC00096 ko00000,ko00002,ko01000,ko03051 Bacteria 234QA@1762,2GMC6@201174,COG0638@1,COG0638@2 NA|NA|NA F Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine OLIIENHM_01538 1440774.Y900_000145 7.4e-114 417.2 Mycobacteriaceae pafB GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 ko:K13572,ko:K13573 ko00000,ko03051 Bacteria 233H6@1762,2GM46@201174,COG2378@1,COG2378@2 NA|NA|NA K Transcriptional regulator OLIIENHM_01539 1299327.I546_6671 5.3e-133 480.7 Mycobacteriaceae pafC GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 ko:K13573 ko00000,ko03051 Bacteria 233Q7@1762,2GMAU@201174,COG2378@1,COG2378@2 NA|NA|NA K WYL domain OLIIENHM_01540 931627.MycrhDRAFT_3930 8.6e-22 109.4 Mycobacteriaceae tatA GO:0008150,GO:0040007 ko:K03116 ko03060,ko03070,map03060,map03070 M00336 ko00000,ko00001,ko00002,ko02044 2.A.64 Bacteria 23ANU@1762,2GQQX@201174,COG1826@1,COG1826@2 NA|NA|NA U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system OLIIENHM_01541 1440774.Y900_000130 6.6e-127 460.3 Mycobacteriaceae tatC GO:0003674,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0040007,GO:0042886,GO:0042887,GO:0043953,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 ko:K03118 ko03060,ko03070,map03060,map03070 M00336 ko00000,ko00001,ko00002,ko02044 2.A.64 Bacteria 232NU@1762,2GJK8@201174,COG0805@1,COG0805@2 NA|NA|NA U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides OLIIENHM_01543 1385517.N800_05725 5.2e-28 132.1 Xanthomonadales yqiK ko:K07192 ko04910,map04910 ko00000,ko00001,ko03036,ko04131,ko04147 Bacteria 1P50K@1224,1RRHJ@1236,1X4V7@135614,COG2268@1,COG2268@2 NA|NA|NA S protein conserved in bacteria OLIIENHM_01544 1150599.MPHLEI_11784 2.2e-37 161.4 Mycobacteriaceae yggT GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02221 ko00000,ko02044 Bacteria 23A4Q@1762,2GQI1@201174,COG0762@1,COG0762@2 NA|NA|NA S integral membrane protein OLIIENHM_01545 1370120.AUWR01000008_gene298 4.5e-47 194.9 Mycobacteriaceae wag31 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008360,GO:0009273,GO:0009987,GO:0016020,GO:0022603,GO:0022604,GO:0030312,GO:0031647,GO:0040007,GO:0042546,GO:0044085,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0050821,GO:0051128,GO:0060187,GO:0065007,GO:0065008,GO:0071554,GO:0071840,GO:0071944 Bacteria 233SW@1762,2GMSC@201174,COG3599@1,COG3599@2 NA|NA|NA D PFAM DivIVA OLIIENHM_01546 1078020.KEK_21128 1.6e-10 73.2 Mycobacteriaceae ko:K14201 ko05150,map05150 ko00000,ko00001 Bacteria 23B62@1762,2E42E@1,2GUHQ@201174,32YYX@2 NA|NA|NA OLIIENHM_01547 931627.MycrhDRAFT_4015 3.1e-211 741.1 Mycobacteriaceae ko:K07071 ko00000 Bacteria 23524@1762,2GJS0@201174,COG1090@1,COG1090@2,COG4276@1,COG4276@2 NA|NA|NA S epimerase OLIIENHM_01548 318424.EU78_08315 1.2e-147 529.6 Mycobacteriaceae asrA ko:K16950 ko00920,ko01120,map00920,map01120 R00858,R10146 RC00065 ko00000,ko00001 Bacteria 23FB8@1762,2GMEQ@201174,COG1143@1,COG1143@2 NA|NA|NA C 4Fe-4S dicluster domain OLIIENHM_01549 557599.MKAN_04235 1.4e-116 426.0 Mycobacteriaceae asrB ko:K02823 ko00240,ko01100,map00240,map01100 ko00000,ko00001 Bacteria 235D0@1762,2HXFY@201174,COG0543@1,COG0543@2 NA|NA|NA C Oxidoreductase OLIIENHM_01550 164757.Mjls_3428 1.4e-107 396.0 Mycobacteriaceae hoxY Bacteria 233M7@1762,2GSPN@201174,COG1941@1,COG1941@2 NA|NA|NA C NADH ubiquinone oxidoreductase, 20 OLIIENHM_01551 216594.MMAR_3497 3e-184 651.4 Mycobacteriaceae hoxH 1.12.1.2 ko:K00436 R00700 ko00000,ko01000 Bacteria 2341Z@1762,2GQ33@201174,COG3259@1,COG3259@2 NA|NA|NA C Nickel-dependent hydrogenase OLIIENHM_01552 164757.Mjls_3426 1.9e-28 132.5 Mycobacteriaceae hoxW ko:K03605 ko00000,ko01000,ko01002 Bacteria 23APC@1762,2IJ3P@201174,COG0680@1,COG0680@2 NA|NA|NA C Hydrogenase maturation protease OLIIENHM_01553 1440774.Y900_023575 7.3e-87 327.0 Mycobacteriaceae guaA1 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 Bacteria 234I4@1762,2GNA6@201174,COG0518@1,COG0518@2 NA|NA|NA F glutamine amidotransferase OLIIENHM_01554 1157943.KB892705_gene865 2.1e-29 135.2 Mycobacteriaceae Bacteria 23AGS@1762,2CNK3@1,2IRH1@201174,32SH9@2 NA|NA|NA S Protein of Unknown function (DUF2784) OLIIENHM_01555 1440774.Y900_023610 1.9e-141 508.8 Mycobacteriaceae terC ko:K05794 ko00000 Bacteria 2339F@1762,2GIWU@201174,COG0861@1,COG0861@2 NA|NA|NA P membrane protein TerC OLIIENHM_01557 1440774.Y900_023650 5.4e-68 264.2 Mycobacteriaceae Bacteria 234CR@1762,2GNR1@201174,COG0515@1,COG0515@2 NA|NA|NA KLT PknH-like extracellular domain OLIIENHM_01558 931627.MycrhDRAFT_3979 2.7e-220 771.2 Mycobacteriaceae dapE2 Bacteria 232BP@1762,2GKKW@201174,COG0624@1,COG0624@2 NA|NA|NA E deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases OLIIENHM_01559 931627.MycrhDRAFT_3978 4.5e-86 323.9 Mycobacteriaceae ybhB GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0042802,GO:0044424,GO:0044464,GO:0071944 ko:K06910 ko00000 Bacteria 2351A@1762,2GMIG@201174,COG1881@1,COG1881@2 NA|NA|NA S Phospholipid-binding protein OLIIENHM_01560 875328.JDM601_1559 1.6e-226 792.0 Mycobacteriaceae Bacteria 23361@1762,2GJEA@201174,COG2072@1,COG2072@2 NA|NA|NA P flavoprotein involved in K transport OLIIENHM_01561 875328.JDM601_1756 3.9e-161 574.3 Mycobacteriaceae pyrD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.3.1.14,1.3.5.2,1.3.98.1 ko:K00226,ko:K00254,ko:K02823,ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01867,R01868,R01869 RC00051 ko00000,ko00001,ko00002,ko01000 Bacteria 2354Y@1762,2GKC6@201174,COG0167@1,COG0167@2 NA|NA|NA F Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor OLIIENHM_01562 931627.MycrhDRAFT_3975 8.5e-32 142.5 Mycobacteriaceae Bacteria 23ANA@1762,2EGVE@1,2GRZT@201174,33AMN@2 NA|NA|NA OLIIENHM_01563 1440774.Y900_023685 7.2e-109 400.6 Mycobacteriaceae lppL Bacteria 232TG@1762,2GMR0@201174,COG3391@1,COG3391@2 NA|NA|NA S amine dehydrogenase activity OLIIENHM_01564 1440774.Y900_023690 2.1e-30 138.3 Mycobacteriaceae Bacteria 23A3Q@1762,2B14F@1,2INBS@201174,31TI9@2 NA|NA|NA OLIIENHM_01565 1440774.Y900_023695 1.5e-120 439.1 Mycobacteriaceae uppP GO:0006950,GO:0008150,GO:0050896,GO:0051409 3.6.1.27 ko:K06153 ko00550,map00550 R05627 RC00002 ko00000,ko00001,ko01000,ko01011 Bacteria 234C2@1762,2GJVG@201174,COG1968@1,COG1968@2 NA|NA|NA V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin OLIIENHM_01566 1440774.Y900_023700 8.7e-98 363.2 Mycobacteriaceae 3.1.3.3,3.1.3.73,5.4.2.11 ko:K01834,ko:K02226,ko:K22305 ko00010,ko00260,ko00680,ko00860,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003,M00122 R00582,R01518,R04594,R11173 RC00017,RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 Bacteria 2343T@1762,2GK8N@201174,COG0406@1,COG0406@2 NA|NA|NA G Phosphoglycerate mutase OLIIENHM_01567 1440774.Y900_023705 1.1e-91 342.8 Mycobacteriaceae Bacteria 233Y5@1762,298YA@1,2GIYI@201174,2ZW25@2 NA|NA|NA S Protein of unknown function (DUF3090) OLIIENHM_01568 931627.MycrhDRAFT_3969 1.5e-112 412.5 Mycobacteriaceae Bacteria 2340Q@1762,2GME7@201174,COG5032@1,COG5032@2 NA|NA|NA BDLTU Phosphatidylinositol OLIIENHM_01569 883126.HMPREF9710_05134 5.1e-22 110.9 Bacteria ko:K03668,ko:K09914 ko00000 Bacteria COG3187@1,COG3187@2 NA|NA|NA O response to heat OLIIENHM_01570 931627.MycrhDRAFT_3968 2.1e-124 451.8 Mycobacteriaceae cysQ GO:0000103,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008441,GO:0008934,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016020,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019637,GO:0019693,GO:0030145,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042132,GO:0042578,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050308,GO:0050427,GO:0050897,GO:0052745,GO:0052834,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564 3.1.3.7 ko:K01082 ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130 R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03016 Bacteria 232H4@1762,2GMW7@201174,COG1218@1,COG1218@2 NA|NA|NA P Inositol monophosphatase OLIIENHM_01571 931627.MycrhDRAFT_3967 4.4e-209 733.8 Mycobacteriaceae cysS GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010125,GO:0010126,GO:0010467,GO:0016020,GO:0016070,GO:0016137,GO:0016138,GO:0016874,GO:0016875,GO:0016879,GO:0016880,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035446,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.1.1.16,6.3.1.13 ko:K01883,ko:K15526 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iNJ661.Rv2130c Bacteria 2368Z@1762,2GJZR@201174,COG0215@1,COG0215@2 NA|NA|NA F Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins OLIIENHM_01572 710686.Mycsm_03806 2e-176 625.5 Mycobacteriaceae Bacteria 233IZ@1762,2GRDZ@201174,COG5361@1,COG5361@2 NA|NA|NA S Protein of unknown function (DUF1254) OLIIENHM_01573 710685.MycrhN_4705 1.2e-157 562.8 Mycobacteriaceae fadE18_2 Bacteria 233SX@1762,2GKVN@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_01574 1440774.Y900_023730 8e-200 703.0 Mycobacteriaceae pimC 1.3.1.62 ko:K04118 ko00362,ko01120,map00362,map01120 R05311 RC00052 ko00000,ko00001,ko01000 Bacteria 235UT@1762,2GM1Q@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_01575 931627.MycrhDRAFT_3963 8.9e-151 539.7 Mycobacteriaceae ko:K07159 ko00000 Bacteria 2348N@1762,2I2H9@201174,COG2047@1,COG2047@2 NA|NA|NA S PAC2 family OLIIENHM_01576 487521.OCU_23690 0.0 1445.6 Mycobacteriaceae metH GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 iECO103_1326.ECO103_4764,iECUMN_1333.ECUMN_4545 Bacteria 2331T@1762,2GM5Q@201174,COG0646@1,COG0646@2,COG1410@1,COG1410@2 NA|NA|NA E Methionine synthase OLIIENHM_01577 1449058.JQKT01000007_gene1307 1.6e-238 832.0 Microbacteriaceae lnt ko:K03820 ko00000,ko01000 GT2 Bacteria 2GJ9F@201174,4FMQQ@85023,COG0815@1,COG0815@2 NA|NA|NA M Transfers the fatty acyl group on membrane lipoproteins OLIIENHM_01578 1449058.JQKT01000007_gene1306 1.8e-149 535.4 Microbacteriaceae ko:K02351,ko:K07245 ko00000,ko02000 9.B.62.1 Bacteria 2GKIR@201174,4FR3B@85023,COG3336@1,COG3336@2 NA|NA|NA S Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) OLIIENHM_01579 1449058.JQKT01000007_gene1305 3.6e-262 910.6 Microbacteriaceae resB ko:K07399 ko00000 Bacteria 2GMGH@201174,4FM4B@85023,COG1333@1,COG1333@2 NA|NA|NA O ResB-like family OLIIENHM_01580 1449058.JQKT01000007_gene1304 1e-38 165.6 Microbacteriaceae ko:K06196 ko00000,ko02000 5.A.1.2 Bacteria 2GJW3@201174,4FMCU@85023,COG0785@1,COG0785@2 NA|NA|NA O Cytochrome C biogenesis protein transmembrane region OLIIENHM_01581 1341646.CBMO010000142_gene2387 1.4e-54 219.5 Mycobacteriaceae Bacteria 236NM@1762,2IKKK@201174,COG5403@1,COG5403@2 NA|NA|NA S Bacterial protein of unknown function (DUF937) OLIIENHM_01582 1440774.Y900_022040 3.2e-191 674.5 Mycobacteriaceae LYS1 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 2341A@1762,2GNGH@201174,COG3268@1,COG3268@2 NA|NA|NA S Saccharopine dehydrogenase OLIIENHM_01583 931627.MycrhDRAFT_4352 5.3e-49 200.7 Mycobacteriaceae ko:K21687,ko:K21689,ko:K21691 ko00000 GH23 Bacteria 239PQ@1762,2IBJ3@201174,COG1388@1,COG1388@2 NA|NA|NA M Transglycosylase-like domain OLIIENHM_01584 1151061.CAJY01000026_gene3654 7.6e-44 183.0 Actinobacteria ko:K21687,ko:K21691 ko00000 GH23 Bacteria 2IMTI@201174,COG1388@1,COG1388@2 NA|NA|NA M Transglycosylase-like domain OLIIENHM_01585 557599.MKAN_05390 3e-56 224.9 Mycobacteriaceae mobA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.7.77 ko:K03752 ko00790,ko01100,map00790,map01100 R11581 ko00000,ko00001,ko01000 Bacteria 234SA@1762,2IACX@201174,COG0746@1,COG0746@2 NA|NA|NA H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor OLIIENHM_01586 1440774.Y900_022010 1.2e-181 642.5 Mycobacteriaceae korB GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016625,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0030312,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046872,GO:0047553,GO:0055114,GO:0071704,GO:0071944,GO:0072350 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 234M1@1762,2GMI5@201174,COG1013@1,COG1013@2 NA|NA|NA C ferredoxin oxidoreductase OLIIENHM_01587 1440774.Y900_022005 1.2e-309 1068.5 Mycobacteriaceae korA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0030312,GO:0044464,GO:0050896,GO:0055114,GO:0071944 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 235IC@1762,2GKXV@201174,COG0674@1,COG0674@2,COG1014@1,COG1014@2 NA|NA|NA C ferredoxin oxidoreductase OLIIENHM_01588 1194972.MVAC_26442 0.0 1313.1 Mycobacteriaceae glnN 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 Bacteria 23305@1762,2GMA9@201174,COG3968@1,COG3968@2 NA|NA|NA S glutamine synthetase OLIIENHM_01589 1150599.MPHLEI_23234 0.0 1232.2 Mycobacteriaceae fdhF GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 R00519 RC02796 ko00000,ko00001,ko01000 iNJ661.Rv2900c Bacteria 234GD@1762,2GJWZ@201174,COG0243@1,COG0243@2 NA|NA|NA C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family OLIIENHM_01590 931627.MycrhDRAFT_4396 5.2e-113 414.1 Mycobacteriaceae fdhD ko:K02379 ko00000 Bacteria 233U2@1762,2GKWC@201174,COG1526@1,COG1526@2 NA|NA|NA C Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH OLIIENHM_01591 350058.Mvan_4036 1.3e-105 389.0 Mycobacteriaceae clpX GO:0000166,GO:0000502,GO:0002020,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009376,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019899,GO:0019904,GO:0030163,GO:0030164,GO:0030312,GO:0030554,GO:0031333,GO:0031597,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0043335,GO:0044087,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0051704,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0097718,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 ko:K03544 ko04112,map04112 ko00000,ko00001,ko03110 Bacteria 2341X@1762,2GJXQ@201174,COG1219@1,COG1219@2 NA|NA|NA O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP OLIIENHM_01592 1120959.ATXF01000005_gene1176 0.0 1097.0 Microbacteriaceae purL GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKG6@201174,4FK8H@85023,COG0046@1,COG0046@2 NA|NA|NA F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL OLIIENHM_01593 1120948.KB903217_gene1248 9.4e-48 196.8 Pseudonocardiales Bacteria 2II0D@201174,4E47X@85010,COG4430@1,COG4430@2 NA|NA|NA S Bacteriocin-protection, YdeI or OmpD-Associated OLIIENHM_01594 710687.KI912270_gene5122 5e-09 66.6 Mycobacteriaceae GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:2000112,GO:2000113 Bacteria 23ADN@1762,2IMGJ@201174,COG1487@1,COG1487@2 NA|NA|NA S Toxic component of a toxin-antitoxin (TA) module. An RNase OLIIENHM_01595 1121933.AUHH01000026_gene3456 5.4e-12 76.6 Propionibacteriales Bacteria 2EI9R@1,2GWXW@201174,33C13@2,4DVZH@85009 NA|NA|NA OLIIENHM_01596 931627.MycrhDRAFT_1136 1.6e-201 708.8 Mycobacteriaceae Bacteria 234HA@1762,2GJQ6@201174,COG0661@1,COG0661@2 NA|NA|NA S ATP-binding protein OLIIENHM_01597 487521.OCU_39900 9.5e-86 323.6 Mycobacteriaceae 2.7.7.80 ko:K21029 ko04122,map04122 R07459 RC00043 ko00000,ko00001,ko01000 Bacteria 232CT@1762,2GMJI@201174,COG0476@1,COG0476@2 NA|NA|NA H UBA ThiF-type NAD FAD binding protein OLIIENHM_01598 931627.MycrhDRAFT_1138 9.2e-200 703.0 Mycobacteriaceae Bacteria 234E9@1762,2GJ9K@201174,COG5282@1,COG5282@2 NA|NA|NA S hydrolase OLIIENHM_01599 1440774.Y900_006040 5.1e-147 527.3 Mycobacteriaceae lon ko:K07177 ko02024,map02024 ko00000,ko00001,ko01002 Bacteria 23501@1762,2GJDD@201174,COG3480@1,COG3480@2 NA|NA|NA T Belongs to the peptidase S16 family OLIIENHM_01600 1440774.Y900_006035 0.0 1593.9 Mycobacteriaceae GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K09118 ko00000 Bacteria 232F3@1762,2GMP3@201174,COG1615@1,COG1615@2 NA|NA|NA S UPF0182 protein OLIIENHM_01602 710686.Mycsm_03984 3e-129 468.4 Mycobacteriaceae Bacteria 235VP@1762,2GIZ3@201174,COG1814@1,COG1814@2 NA|NA|NA S VIT family OLIIENHM_01603 350058.Mvan_4029 4.3e-88 330.9 Mycobacteriaceae yjbH Bacteria 237V9@1762,2HWM3@201174,COG2761@1,COG2761@2 NA|NA|NA Q dithiol-disulfide isomerase involved in polyketide biosynthesis OLIIENHM_01605 931627.MycrhDRAFT_2003 3.1e-270 937.9 Mycobacteriaceae Bacteria 23FE6@1762,2I9HI@201174,COG3866@1,COG3866@2,COG4932@1,COG4932@2 NA|NA|NA GM domain protein OLIIENHM_01606 1449048.JQKU01000009_gene715 1.1e-180 641.0 Mycobacteriaceae 3.1.3.64 ko:K21302 ko00562,ko01100,ko05152,map00562,map01100,map05152 ko00000,ko00001,ko01000 Bacteria 23EUT@1762,2GQGM@201174,COG3511@1,COG3511@2 NA|NA|NA M Phosphoesterase family OLIIENHM_01607 931627.MycrhDRAFT_2935 7.2e-118 430.3 Mycobacteriaceae Bacteria 232H9@1762,2GM6W@201174,COG1028@1,COG1028@2 NA|NA|NA IQ NAD-dependent epimerase OLIIENHM_01608 931627.MycrhDRAFT_2934 3.3e-24 118.2 Bacteria ko:K02030,ko:K14475 ko05143,map05143 M00236 ko00000,ko00001,ko00002,ko02000 3.A.1.3 Bacteria COG5513@1,COG5513@2 NA|NA|NA G serine-type aminopeptidase activity OLIIENHM_01609 931627.MycrhDRAFT_2932 5.9e-52 210.7 Mycobacteriaceae lpqJ Bacteria 238NB@1762,2B7Q4@1,2IEHY@201174,320VZ@2 NA|NA|NA OLIIENHM_01610 1440774.Y900_015535 2.5e-135 488.4 Mycobacteriaceae 1.14.14.5 ko:K04091 ko00920,map00920 R07210,R10206 RC01779,RC02556 ko00000,ko00001,ko01000 Bacteria 232XZ@1762,2GJ6T@201174,COG2141@1,COG2141@2 NA|NA|NA C F420-dependent OLIIENHM_01611 931627.MycrhDRAFT_2929 3.7e-23 115.2 Mycobacteriaceae Bacteria 239T0@1762,2AXNC@1,2IIBI@201174,31PNQ@2 NA|NA|NA OLIIENHM_01612 1150599.MPHLEI_10605 1.2e-203 716.1 Mycobacteriaceae iniC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 Bacteria 233X6@1762,2GK6T@201174,COG0699@1,COG0699@2 NA|NA|NA S Isoniazid inducible protein IniC OLIIENHM_01613 1440774.Y900_015510 8.7e-262 909.4 Mycobacteriaceae iniA GO:0003674,GO:0005215,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0015562,GO:0016020,GO:0022857,GO:0030312,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 Bacteria 233R2@1762,2GNGP@201174,COG0699@1,COG0699@2 NA|NA|NA S Dynamin family OLIIENHM_01614 1440774.Y900_015505 8e-81 307.4 Mycobacteriaceae iniB Bacteria 236FX@1762,2DNCF@1,2GP5B@201174,32WSK@2 NA|NA|NA OLIIENHM_01615 931627.MycrhDRAFT_2924 1.9e-14 85.9 Mycobacteriaceae Bacteria 23AMS@1762,2BXHV@1,2IQUF@201174,32SK8@2 NA|NA|NA OLIIENHM_01616 1440774.Y900_015495 2.9e-183 648.7 Mycobacteriaceae Bacteria 232QM@1762,2GNTE@201174,COG0443@1,COG0443@2 NA|NA|NA O Molecular chaperone OLIIENHM_01617 1440774.Y900_015490 1.2e-242 846.3 Mycobacteriaceae gerE ko:K21405 ko00000,ko03000 Bacteria 234EM@1762,2I2NT@201174,COG2771@1,COG2771@2 NA|NA|NA K Transcriptional regulator OLIIENHM_01618 710686.Mycsm_00354 0.0 1231.5 Mycobacteriaceae fimV_2 ko:K19719 ko04151,ko04510,ko04512,ko04974,ko05165,map04151,map04510,map04512,map04974,map05165 ko00000,ko00001,ko00536 Bacteria 232WS@1762,2GJ7M@201174,COG0247@1,COG0247@2,COG3266@1,COG3266@2 NA|NA|NA C Fe-S oxidoreductase OLIIENHM_01619 1440774.Y900_015480 2e-36 158.7 Mycobacteriaceae Bacteria 23AQR@1762,2AU6A@1,2IT5Q@201174,31R5P@2 NA|NA|NA OLIIENHM_01620 258533.BN977_04073 1e-224 785.8 Mycobacteriaceae alaA GO:0003674,GO:0003824,GO:0004021,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006090,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009078,GO:0009079,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016769,GO:0019272,GO:0019752,GO:0019842,GO:0030170,GO:0030632,GO:0032787,GO:0033554,GO:0036094,GO:0040007,GO:0042221,GO:0042851,GO:0042852,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0046677,GO:0047635,GO:0048037,GO:0050662,GO:0050896,GO:0051716,GO:0070279,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.2,2.6.1.66 ko:K00814,ko:K14260 ko00220,ko00250,ko00290,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00220,map00250,map00290,map00710,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00171 R00258,R01215 RC00006,RC00008,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 iNJ661.Rv0337c Bacteria 234XK@1762,2GJ7R@201174,COG0436@1,COG0436@2 NA|NA|NA E Aminotransferase OLIIENHM_01621 1440774.Y900_015470 1.9e-175 622.1 Mycobacteriaceae yibF Bacteria 2346T@1762,2GKJ4@201174,COG5438@1,COG5438@2 NA|NA|NA S YibE F family protein OLIIENHM_01622 1448389.BAVQ01000036_gene873 6.2e-133 480.3 Actinobacteria rfbA GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005976,GO:0005996,GO:0006006,GO:0006139,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008879,GO:0009058,GO:0009059,GO:0009117,GO:0009141,GO:0009147,GO:0009200,GO:0009211,GO:0009219,GO:0009225,GO:0009226,GO:0009262,GO:0009394,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019299,GO:0019300,GO:0019305,GO:0019318,GO:0019319,GO:0019438,GO:0019637,GO:0019692,GO:0030312,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045226,GO:0046075,GO:0046364,GO:0046379,GO:0046383,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv0334,iSDY_1059.SDY_2206,iSF_1195.SF2102,iSFxv_1172.SFxv_2338,iS_1188.S2225,iUMNK88_1353.UMNK88_4598,iYL1228.KPN_04289 Bacteria 2GP20@201174,COG1209@1,COG1209@2 NA|NA|NA M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis OLIIENHM_01623 1440774.Y900_015460 4.2e-46 190.7 Mycobacteriaceae Bacteria 239W4@1762,2EQV0@1,2IM90@201174,33IET@2 NA|NA|NA S SnoaL-like domain OLIIENHM_01624 1440774.Y900_015455 1.8e-115 422.2 Mycobacteriaceae Bacteria 233HZ@1762,2GJ1X@201174,COG3550@1,COG3550@2 NA|NA|NA S MDMPI C-terminal domain OLIIENHM_01625 350058.Mvan_4537 1.5e-28 132.1 Mycobacteriaceae 1.13.12.16,1.3.1.9 ko:K00459,ko:K02371 ko00061,ko00910,ko01100,ko01212,map00061,map00910,map01100,map01212 M00083 R00025,R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765 RC00052,RC00076,RC02541,RC02759 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 235GN@1762,2GKA6@201174,COG2070@1,COG2070@2 NA|NA|NA S 2-nitropropane dioxygenase OLIIENHM_01626 710687.KI912270_gene2277 9.9e-60 236.5 Mycobacteriaceae GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141 Bacteria 236S0@1762,2GJHD@201174,COG1309@1,COG1309@2 NA|NA|NA K Transcriptional regulator OLIIENHM_01627 1209984.BN978_03081 3.2e-45 188.0 Mycobacteriaceae Bacteria 238MH@1762,2BG05@1,2IGFG@201174,329UM@2 NA|NA|NA S Mycobacterium membrane protein OLIIENHM_01628 1440774.Y900_012810 0.0 1323.1 Mycobacteriaceae ko:K06994 ko00000 Bacteria 232PC@1762,2GKX6@201174,COG2409@1,COG2409@2 NA|NA|NA S transport protein OLIIENHM_01629 1150599.MPHLEI_09554 1.5e-35 156.4 Mycobacteriaceae arpA_2 Bacteria 236AQ@1762,2I8MS@201174,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family OLIIENHM_01630 931627.MycrhDRAFT_6557 6e-210 736.9 Mycobacteriaceae amiC GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 Bacteria 233B4@1762,2GKPZ@201174,COG0154@1,COG0154@2 NA|NA|NA J Belongs to the amidase family OLIIENHM_01631 525368.HMPREF0591_6208 7.9e-122 443.4 Mycobacteriaceae tsf GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0030312,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02357 ko00000,ko03012,ko03029 Bacteria 232E0@1762,2GK4M@201174,COG0264@1,COG0264@2 NA|NA|NA J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome OLIIENHM_01632 246196.MSMEI_2460 3.2e-134 484.6 Mycobacteriaceae rpsB GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02967 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 232CZ@1762,2GMYC@201174,COG0052@1,COG0052@2 NA|NA|NA J Belongs to the universal ribosomal protein uS2 family OLIIENHM_01633 258533.BN977_05534 1.1e-60 239.6 Mycobacteriaceae Bacteria 239DY@1762,2IQ64@201174,COG0739@1,COG0739@2 NA|NA|NA M peptidase OLIIENHM_01634 1440774.Y900_003400 4.2e-140 504.2 Mycobacteriaceae xerC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03733,ko:K04763 ko00000,ko03036 Bacteria 235IF@1762,2GNDP@201174,COG4974@1,COG4974@2 NA|NA|NA D Belongs to the 'phage' integrase family. XerC subfamily OLIIENHM_01635 246196.MSMEI_3413 4.3e-59 234.6 Mycobacteriaceae Bacteria 238UK@1762,2ARRN@1,2IG68@201174,31H2R@2 NA|NA|NA S Domain of unknown function (DUF5078) OLIIENHM_01636 1440774.Y900_003410 3.6e-57 227.6 Mycobacteriaceae mmpS4_1 Bacteria 239CA@1762,2BG05@1,2II7M@201174,31IP3@2 NA|NA|NA S Mycobacterium membrane protein OLIIENHM_01637 1440774.Y900_003415 0.0 1494.2 Mycobacteriaceae mmpL5_5 ko:K06994 ko00000 Bacteria 233SM@1762,2GKX6@201174,COG2409@1,COG2409@2 NA|NA|NA S transport protein OLIIENHM_01638 1440774.Y900_003425 8.3e-146 523.5 Mycobacteriaceae dprA 5.99.1.2 ko:K03168,ko:K04096 ko00000,ko01000,ko03032,ko03400 Bacteria 235JM@1762,2GKDA@201174,COG0758@1,COG0758@2 NA|NA|NA LU DNA protecting protein DprA OLIIENHM_01639 1440774.Y900_003430 8e-229 799.7 Mycobacteriaceae comM GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 ko:K07391 ko00000 Bacteria 235HY@1762,2GJIQ@201174,COG0606@1,COG0606@2 NA|NA|NA O chelatase subunit ChlI OLIIENHM_01640 931627.MycrhDRAFT_6545 2.1e-45 188.3 Mycobacteriaceae yraN ko:K07460 ko00000 Bacteria 239W7@1762,2IQ3X@201174,COG0792@1,COG0792@2 NA|NA|NA L Belongs to the UPF0102 family OLIIENHM_01641 1440774.Y900_003485 6.7e-50 203.0 Mycobacteriaceae GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 23978@1762,2AFXT@1,2IKPZ@201174,3161G@2 NA|NA|NA S Protein of unknown function (DUF2469) OLIIENHM_01642 710686.Mycsm_02313 2.6e-105 388.3 Mycobacteriaceae rnhB GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 ko:K03470 ko03030,map03030 ko00000,ko00001,ko01000,ko03032 Bacteria 23391@1762,2GJFN@201174,COG0164@1,COG0164@2 NA|NA|NA L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids OLIIENHM_01643 931627.MycrhDRAFT_6535 4.8e-127 460.7 Mycobacteriaceae lepB GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 ko00000,ko00001,ko01000,ko01002 Bacteria 2342C@1762,2GIYN@201174,COG0681@1,COG0681@2 NA|NA|NA U Belongs to the peptidase S26 family OLIIENHM_01644 931627.MycrhDRAFT_6534 1.3e-54 218.8 Mycobacteriaceae rplS GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02884 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 239BS@1762,2IHRT@201174,COG0335@1,COG0335@2 NA|NA|NA J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site OLIIENHM_01645 1440774.Y900_003505 7.2e-100 370.5 Mycobacteriaceae lppW GO:0005575,GO:0005576 Bacteria 233HV@1762,2GKPU@201174,COG2367@1,COG2367@2 NA|NA|NA V Beta-lactamase OLIIENHM_01646 1380386.JIAW01000008_gene6170 9.1e-111 406.4 Mycobacteriaceae trmD GO:0000287,GO:0001510,GO:0002939,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050518,GO:0052906,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228,4.6.1.12 ko:K00554,ko:K01770 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R00597,R05637 RC00002,RC00003,RC00334,RC01440 ko00000,ko00001,ko00002,ko01000,ko03016 Bacteria 232MC@1762,2GJ1G@201174,COG0336@1,COG0336@2 NA|NA|NA J Belongs to the RNA methyltransferase TrmD family OLIIENHM_01647 931627.MycrhDRAFT_6526 1.5e-65 255.8 Mycobacteriaceae rimM GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 ko:K02860 ko00000,ko03009 Bacteria 238SB@1762,2GK4I@201174,COG0806@1,COG0806@2 NA|NA|NA J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes OLIIENHM_01648 1078020.KEK_18713 3.7e-35 153.7 Mycobacteriaceae CP_0960 GO:0008150,GO:0040007 ko:K06960 ko00000 Bacteria 23AP5@1762,2IQ4C@201174,COG1837@1,COG1837@2 NA|NA|NA S Belongs to the UPF0109 family OLIIENHM_01649 1440774.Y900_003530 4e-63 247.7 Mycobacteriaceae rpsP GO:0000028,GO:0000217,GO:0000400,GO:0003674,GO:0003676,GO:0003677,GO:0003735,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006259,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016787,GO:0016788,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02959 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011,ko03029 Bacteria 238NH@1762,2IKU0@201174,COG0228@1,COG0228@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bS16 family OLIIENHM_01650 700508.D174_11055 2.2e-59 235.0 Mycobacteriaceae Bacteria 238N6@1762,2IFNT@201174,COG5517@1,COG5517@2 NA|NA|NA Q SnoaL-like domain OLIIENHM_01651 1440774.Y900_003545 4e-119 434.5 Mycobacteriaceae dacB 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 ko00000,ko00001,ko01000,ko01002,ko01011 Bacteria 236CG@1762,2GK3M@201174,COG1686@1,COG1686@2 NA|NA|NA M Belongs to the peptidase S11 family OLIIENHM_01652 931627.MycrhDRAFT_6519 8.5e-58 230.3 Mycobacteriaceae Bacteria 239YM@1762,29WEB@1,2IKZZ@201174,31M8B@2 NA|NA|NA S Domain of unknown function (DUF1942) OLIIENHM_01653 931627.MycrhDRAFT_6516 5.9e-93 347.4 Mycobacteriaceae dac 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 ko00000,ko00001,ko01000,ko01002,ko01011 Bacteria 233YF@1762,2GK3M@201174,COG1686@1,COG1686@2 NA|NA|NA M Belongs to the peptidase S11 family OLIIENHM_01654 931627.MycrhDRAFT_6515 5.7e-160 570.5 Mycobacteriaceae 3.5.2.7 ko:K01468 ko00340,ko01100,map00340,map01100 M00045 R02288 RC00683 ko00000,ko00001,ko00002,ko01000 Bacteria 2348S@1762,2GKRZ@201174,COG1228@1,COG1228@2 NA|NA|NA Q amidohydrolase OLIIENHM_01655 931627.MycrhDRAFT_6514 2.3e-255 887.9 Mycobacteriaceae ffh GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006605,GO:0006612,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0030312,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0040007,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046907,GO:0048500,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0071944,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1990904 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 Bacteria 232TC@1762,2GK4R@201174,COG0541@1,COG0541@2 NA|NA|NA U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY OLIIENHM_01656 1440774.Y900_003570 0.0 1235.7 Mycobacteriaceae glnD GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008773,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0030312,GO:0044464,GO:0070566,GO:0070569,GO:0071944,GO:0140096 2.7.7.59 ko:K00990 ko02020,map02020 ko00000,ko00001,ko01000 Bacteria 232M8@1762,2GMKT@201174,COG2844@1,COG2844@2 NA|NA|NA O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen OLIIENHM_01657 1370125.AUWT01000067_gene3758 1.9e-50 204.9 Mycobacteriaceae glnB GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0008150,GO:0016020,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043531,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363 ko:K04751 ko02020,map02020 ko00000,ko00001 Bacteria 2397Y@1762,2IKN1@201174,COG0347@1,COG0347@2 NA|NA|NA K nitrogen regulatory protein P-II OLIIENHM_01658 258533.BN977_05493 1.3e-209 735.7 Mycobacteriaceae amt ko:K03320 ko00000,ko02000 1.A.11 iNJ661.Rv2920c Bacteria 234YA@1762,2GIZK@201174,COG0004@1,COG0004@2 NA|NA|NA U Ammonium Transporter OLIIENHM_01659 931627.MycrhDRAFT_6510 9.2e-184 649.8 Mycobacteriaceae ftsY GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 Bacteria 23680@1762,2GJQH@201174,COG0552@1,COG0552@2 NA|NA|NA U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) OLIIENHM_01660 1440774.Y900_003590 2.9e-134 485.0 Mycobacteriaceae fni GO:0003674,GO:0003824,GO:0004452,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016853,GO:0016860,GO:0016863,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0071704,GO:1901576 5.3.3.2 ko:K01823 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00095,M00096,M00364,M00365,M00366,M00367 R01123 RC00455 ko00000,ko00001,ko00002,ko01000 Bacteria 2360G@1762,2GIWD@201174,COG1304@1,COG1304@2 NA|NA|NA C Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) OLIIENHM_01661 419947.MRA_2114 6.1e-152 544.3 Mycobacteriaceae GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 Bacteria 232ST@1762,2GP2N@201174,COG1403@1,COG1403@2 NA|NA|NA V HNH endonuclease OLIIENHM_01662 931627.MycrhDRAFT_2923 5.4e-09 68.6 Mycobacteriaceae Bacteria 232QM@1762,2GNTE@201174,COG0443@1,COG0443@2 NA|NA|NA O Molecular chaperone OLIIENHM_01664 1172186.KB911466_gene1578 1.9e-101 376.7 Mycobacteriaceae ko:K03088 ko00000,ko03021 Bacteria 23459@1762,2GRZW@201174,COG1595@1,COG1595@2 NA|NA|NA K Sigma-70 region 2 OLIIENHM_01665 1440774.Y900_003610 0.0 1409.4 Mycobacteriaceae smc GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 ko:K03529,ko:K19171 ko00000,ko02048,ko03036 Bacteria 2361G@1762,2GK93@201174,COG1196@1,COG1196@2 NA|NA|NA D Required for chromosome condensation and partitioning OLIIENHM_01666 1078020.KEK_12418 2.4e-10 71.6 Mycobacteriaceae Bacteria 234YC@1762,2AMYC@1,2I99N@201174,31CVF@2 NA|NA|NA OLIIENHM_01667 710685.MycrhN_4073 8.9e-74 284.3 Mycobacteriaceae 3.1.3.3 ko:K07315,ko:K20971 ko02025,map02025 ko00000,ko00001,ko01000,ko01001,ko02022,ko03021 Bacteria 23FCK@1762,2I43Y@201174,COG2208@1,COG2208@2,COG4251@1,COG4251@2 NA|NA|NA T GAF domain OLIIENHM_01669 710686.Mycsm_00699 3.6e-77 294.3 Mycobacteriaceae trpF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 ko:K09767 ko00000 Bacteria 232N6@1762,2IFIU@201174,COG1666@1,COG1666@2 NA|NA|NA S Belongs to the UPF0234 family OLIIENHM_01670 1440774.Y900_017235 2.9e-218 764.6 Mycobacteriaceae ko:K10215 ko00627,ko01120,map00627,map01120 R07836,R07837 RC02100,RC03121 ko00000,ko00001,ko01000 Bacteria 232R1@1762,2GJEA@201174,COG2072@1,COG2072@2 NA|NA|NA P Flavoprotein involved in K transport OLIIENHM_01671 1440774.Y900_017230 2.3e-166 591.7 Mycobacteriaceae gpsA 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 R00842,R00844 RC00029 ko00000,ko00001,ko01000 Bacteria 232KM@1762,2GJSD@201174,COG0240@1,COG0240@2 NA|NA|NA I Glycerol-3-phosphate dehydrogenase OLIIENHM_01672 931627.MycrhDRAFT_3263 6e-49 200.7 Mycobacteriaceae Bacteria 23ABK@1762,2AVWI@1,2INA0@201174,31MQD@2 NA|NA|NA OLIIENHM_01674 1209984.BN978_01210 3.6e-128 464.5 Mycobacteriaceae htpX GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K03799 M00743 ko00000,ko00002,ko01000,ko01002 Bacteria 232WY@1762,2GMJF@201174,COG0501@1,COG0501@2 NA|NA|NA O Belongs to the peptidase M48B family OLIIENHM_01675 931627.MycrhDRAFT_3259 1.4e-152 545.8 Mycobacteriaceae hepS GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.5.1.30 ko:K00805 ko00900,ko01110,map00900,map01110 R09247 RC00279 ko00000,ko00001,ko01000,ko01006 Bacteria 2357W@1762,2GMB4@201174,COG0142@1,COG0142@2 NA|NA|NA H Belongs to the FPP GGPP synthase family OLIIENHM_01676 1440774.Y900_017210 1.8e-191 675.2 Mycobacteriaceae menJ GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016491,GO:0016627,GO:0030312,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663 1.3.99.38 ko:K21401 ko00000,ko01000 Bacteria 2337K@1762,2GKGH@201174,COG0644@1,COG0644@2 NA|NA|NA C geranylgeranyl reductase OLIIENHM_01677 1370120.AUWR01000040_gene106 3.1e-103 381.3 Mycobacteriaceae ubiE GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008425,GO:0008757,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0030580,GO:0032259,GO:0040007,GO:0042180,GO:0042181,GO:0043333,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 iAF1260.b3833,iBWG_1329.BWG_3511,iE2348C_1286.E2348C_4147,iEC042_1314.EC042_4213,iEC55989_1330.EC55989_4310,iECDH10B_1368.ECDH10B_4024,iECDH1ME8569_1439.ECDH1ME8569_3712,iECH74115_1262.ECH74115_5274,iECIAI1_1343.ECIAI1_4028,iECIAI39_1322.ECIAI39_3162,iECO103_1326.ECO103_4330,iECO111_1330.ECO111_4661,iECO26_1355.ECO26_4752,iECSE_1348.ECSE_4121,iECSP_1301.ECSP_4888,iECUMN_1333.ECUMN_4359,iECW_1372.ECW_m4135,iECs_1301.ECs4763,iEKO11_1354.EKO11_4524,iETEC_1333.ETEC_4110,iEcDH1_1363.EcDH1_4146,iEcE24377_1341.EcE24377A_4354,iEcHS_1320.EcHS_A4057,iEcSMS35_1347.EcSMS35_4216,iEcolC_1368.EcolC_4175,iG2583_1286.G2583_4633,iJO1366.b3833,iJR904.b3833,iSBO_1134.SBO_3847,iSDY_1059.SDY_3910,iSFV_1184.SFV_3665,iSF_1195.SF3911,iSFxv_1172.SFxv_4263,iSSON_1240.SSON_4008,iS_1188.S3843,iSbBS512_1146.SbBS512_E4305,iUMNK88_1353.UMNK88_4663,iWFL_1372.ECW_m4135,iY75_1357.Y75_RS17910,iZ_1308.Z5355 Bacteria 233Y7@1762,2GKFZ@201174,COG0500@1,COG2226@2 NA|NA|NA H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) OLIIENHM_01679 931627.MycrhDRAFT_3251 1.5e-57 229.2 Mycobacteriaceae Bacteria 238RG@1762,2EDS1@1,2IQ90@201174,337MI@2 NA|NA|NA OLIIENHM_01680 1440774.Y900_017170 5.4e-255 886.7 Mycobacteriaceae menD GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 2.2.1.9 ko:K02551 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R08165 RC02186 ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS05085 Bacteria 233II@1762,2GMEB@201174,COG1165@1,COG1165@2 NA|NA|NA H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) OLIIENHM_01681 1440774.Y900_017165 2.8e-108 398.3 Mycobacteriaceae bpoC Bacteria 233NN@1762,2I39T@201174,COG2267@1,COG2267@2 NA|NA|NA I Alpha beta hydrolase OLIIENHM_01682 1370121.AUWS01000071_gene81 8.8e-68 263.1 Mycobacteriaceae tpx GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009405,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0015036,GO:0016209,GO:0016491,GO:0016667,GO:0016671,GO:0016684,GO:0019725,GO:0020012,GO:0030312,GO:0030682,GO:0032843,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0051920,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071944,GO:0075136,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 ko:K11065 ko00000,ko01000 Bacteria 233ZP@1762,2II20@201174,COG2077@1,COG2077@2 NA|NA|NA O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides OLIIENHM_01683 931627.MycrhDRAFT_3244 1.5e-132 479.2 Mycobacteriaceae menC GO:0008150,GO:0040007 4.2.1.113,5.1.1.20,5.1.1.3 ko:K01776,ko:K02549,ko:K19802 ko00130,ko00471,ko01100,ko01110,map00130,map00471,map01100,map01110 M00116 R00260,R04031,R10938 RC00302,RC01053,RC03309 ko00000,ko00001,ko00002,ko01000,ko01011 iNJ661.Rv0553,iSB619.SA_RS09080 Bacteria 232UR@1762,2GJJR@201174,COG4948@1,COG4948@2 NA|NA|NA H Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) OLIIENHM_01684 931627.MycrhDRAFT_3243 2.3e-239 834.7 Mycobacteriaceae MA20_16355 6.2.1.3 ko:K00666,ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 Bacteria 232ME@1762,2GIUC@201174,COG0318@1,COG0318@2 NA|NA|NA IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II OLIIENHM_01685 931627.MycrhDRAFT_3242 1.9e-201 708.8 Mycobacteriaceae Bacteria 233QJ@1762,2I6YG@201174,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily OLIIENHM_01686 931627.MycrhDRAFT_3228 6e-275 953.0 Mycobacteriaceae fadD8 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0051087 ko:K00666 ko00000,ko01000,ko01004 Bacteria 234S3@1762,2GIUC@201174,COG0318@1,COG0318@2 NA|NA|NA IQ Activates fatty acids by binding to coenzyme A OLIIENHM_01687 931627.MycrhDRAFT_3226 1.4e-68 266.2 Mycobacteriaceae ko:K07025 ko00000 Bacteria 2362P@1762,2GN5U@201174,COG1011@1,COG1011@2 NA|NA|NA S haloacid dehalogenase OLIIENHM_01688 931627.MycrhDRAFT_3223 3.6e-91 341.7 Mycobacteriaceae Bacteria 234UA@1762,2GJTD@201174,COG0300@1,COG0300@2 NA|NA|NA S Belongs to the short-chain dehydrogenases reductases (SDR) family OLIIENHM_01689 350058.Mvan_0942 6e-56 223.4 Mycobacteriaceae gloA 4.4.1.5 ko:K01759 ko00620,map00620 R02530 RC00004,RC00740 ko00000,ko00001,ko01000 Bacteria 239BK@1762,2IHZH@201174,COG0346@1,COG0346@2 NA|NA|NA E Glyoxalase bleomycin resistance protein dioxygenase OLIIENHM_01690 1440774.Y900_017070 1.7e-30 138.7 Mycobacteriaceae Bacteria 23AR4@1762,2E7QJ@1,2GR2A@201174,33260@2 NA|NA|NA S Protein of unknown function (DUF3349) OLIIENHM_01691 1298864.AUEQ01000024_gene1448 3.7e-26 124.0 Mycobacteriaceae Bacteria 23AJS@1762,2EGF0@1,2IS8P@201174,33I9S@2 NA|NA|NA OLIIENHM_01692 1341646.CBMO010000038_gene4713 8.5e-168 596.7 Mycobacteriaceae pit ko:K03306 ko00000 2.A.20 Bacteria 234S8@1762,2GJHK@201174,COG0306@1,COG0306@2 NA|NA|NA P phosphate transporter OLIIENHM_01693 1440774.Y900_017050 1.8e-145 522.3 Mycobacteriaceae menE GO:0003674,GO:0003824,GO:0008150,GO:0008756,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0040007 6.2.1.26 ko:K01911 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R04030 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 Bacteria 233RU@1762,2GN9C@201174,COG0318@1,COG0318@2 NA|NA|NA IQ O-succinylbenzoic acid--CoA ligase OLIIENHM_01694 1440774.Y900_016995 1.3e-112 412.5 Mycobacteriaceae Bacteria 233KW@1762,2GK5S@201174,COG0745@1,COG0745@2 NA|NA|NA T PFAM response regulator receiver OLIIENHM_01695 710687.KI912270_gene3266 4.2e-128 464.5 Mycobacteriaceae Bacteria 235G6@1762,2I3JI@201174,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor OLIIENHM_01696 1205680.CAKO01000002_gene2468 4.4e-57 228.4 Rhodospirillales Bacteria 1RCD1@1224,2JT0X@204441,2U1XT@28211,COG0523@1,COG0523@2 NA|NA|NA S Cobalamin synthesis protein cobW C-terminal domain OLIIENHM_01697 1313172.YM304_15150 1.1e-162 580.1 Actinobacteria Bacteria 2GJVW@201174,COG1574@1,COG1574@2 NA|NA|NA E amidohydrolase OLIIENHM_01698 1440774.Y900_016980 2.6e-176 624.8 Mycobacteriaceae MA20_16415 Bacteria 233FN@1762,2GKGT@201174,COG2070@1,COG2070@2 NA|NA|NA S 2-nitropropane dioxygenase OLIIENHM_01699 1440774.Y900_016960 5.7e-125 453.8 Mycobacteriaceae mtnP 2.4.2.28 ko:K00772 ko00270,ko01100,map00270,map01100 M00034 R01402 RC00063,RC02819 ko00000,ko00001,ko00002,ko01000 Bacteria 235B3@1762,2GKGG@201174,COG0005@1,COG0005@2 NA|NA|NA F Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates OLIIENHM_01700 1380386.JIAW01000015_gene6394 2.1e-48 199.1 Mycobacteriaceae Bacteria 23763@1762,2IIVD@201174,COG4291@1,COG4291@2 NA|NA|NA S Protein of unknown function (DUF1345) OLIIENHM_01701 1440774.Y900_016945 6.4e-130 470.3 Mycobacteriaceae menA GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006775,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009233,GO:0009234,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0032194,GO:0042180,GO:0042181,GO:0042362,GO:0042371,GO:0042373,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046428,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663 2.5.1.74 ko:K02548 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R05617,R06858,R10757 RC02935,RC02936,RC03264 ko00000,ko00001,ko00002,ko01000,ko01006 iECH74115_1262.ECH74115_5387,iG2583_1286.G2583_4737 Bacteria 232II@1762,2GJBS@201174,COG1575@1,COG1575@2 NA|NA|NA H Belongs to the MenA family. Type 1 subfamily OLIIENHM_01702 529884.Rhola_00006650 4.7e-48 197.2 Actinobacteria 4.2.99.21 ko:K04782 ko01053,ko01110,ko01130,map01053,map01110,map01130 R06602 RC01549,RC02148 ko00000,ko00001,ko01000 Bacteria 2IIB2@201174,COG0251@1,COG0251@2 NA|NA|NA J endoribonuclease L-PSP OLIIENHM_01703 1440774.Y900_016940 1.5e-24 118.6 Mycobacteriaceae Bacteria 23AND@1762,2CG79@1,2IQGE@201174,348SE@2 NA|NA|NA S Protein of unknown function (DUF4229) OLIIENHM_01704 931627.MycrhDRAFT_3196 6e-10 69.3 Mycobacteriaceae Bacteria 23B8Q@1762,2B11T@1,2GSB8@201174,31TF7@2 NA|NA|NA OLIIENHM_01705 164757.Mjls_0688 1.5e-151 542.3 Mycobacteriaceae ccsA GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008152,GO:0015886,GO:0016020,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0055114,GO:0071702,GO:0071705,GO:0071944,GO:1901678 Bacteria 23588@1762,2GJR1@201174,COG0755@1,COG0755@2 NA|NA|NA O Cytochrome C assembly protein OLIIENHM_01706 931627.MycrhDRAFT_3193 6.7e-231 806.6 Mycobacteriaceae resB ko:K07399 ko00000 Bacteria 232SF@1762,2GMGH@201174,COG1333@1,COG1333@2 NA|NA|NA O ResB protein required for cytochrome c biosynthesis OLIIENHM_01707 931627.MycrhDRAFT_3192 4.1e-104 384.4 Mycobacteriaceae ccdA ko:K06196 ko00000,ko02000 5.A.1.2 Bacteria 232I3@1762,2GJW3@201174,COG0785@1,COG0785@2 NA|NA|NA O cytochrome c biogenesis protein OLIIENHM_01708 1440774.Y900_016910 1.8e-91 342.0 Mycobacteriaceae resA ko:K02199 ko00000,ko03110 Bacteria 2341I@1762,2GP7J@201174,COG0526@1,COG0526@2 NA|NA|NA CO Alkyl hydroperoxide reductase OLIIENHM_01709 931627.MycrhDRAFT_3190 4.8e-100 370.5 Mycobacteriaceae GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 3.1.3.3,3.1.3.73 ko:K02226,ko:K22305 ko00260,ko00680,ko00860,ko01100,ko01120,ko01130,map00260,map00680,map00860,map01100,map01120,map01130 M00122 R00582,R04594,R11173 RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 235XW@1762,2GMXF@201174,COG0406@1,COG0406@2 NA|NA|NA G phosphoglycerate mutase OLIIENHM_01710 931627.MycrhDRAFT_3189 8.8e-208 729.6 Mycobacteriaceae hemL GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016853,GO:0016866,GO:0016869,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042286,GO:0042440,GO:0042802,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 iSB619.SA_RS08395,iUMNK88_1353.UMNK88_158 Bacteria 2333M@1762,2GJSH@201174,COG0001@1,COG0001@2 NA|NA|NA H Aminotransferase OLIIENHM_01711 1440774.Y900_016895 1.7e-22 111.7 Bacteria feoA ko:K04758 ko00000,ko02000 Bacteria COG1918@1,COG1918@2 NA|NA|NA P iron ion homeostasis OLIIENHM_01714 1440774.Y900_013645 1.8e-241 842.0 Mycobacteriaceae kup ko:K03549 ko00000,ko02000 2.A.72 Bacteria 234KX@1762,2GMPQ@201174,COG3158@1,COG3158@2 NA|NA|NA P Transport of potassium into the cell OLIIENHM_01715 1440774.Y900_013625 1e-46 193.0 Mycobacteriaceae Bacteria 239XD@1762,2AUG8@1,2IMAY@201174,30TI5@2 NA|NA|NA OLIIENHM_01716 547163.BN979_05422 8.4e-106 390.2 Mycobacteriaceae gluP 3.4.21.105 ko:K19225 ko00000,ko01000,ko01002 Bacteria 235N2@1762,2GJYG@201174,COG0705@1,COG0705@2,COG3063@1,COG3063@2 NA|NA|NA NU Rhomboid family OLIIENHM_01717 931627.MycrhDRAFT_2367 3.5e-33 147.9 Mycobacteriaceae Bacteria 23B77@1762,29SDW@1,2GWFE@201174,30DIM@2 NA|NA|NA S STAS domain OLIIENHM_01718 931627.MycrhDRAFT_2366 9.2e-86 323.2 Mycobacteriaceae Bacteria 235A0@1762,2HU76@201174,COG0500@1,COG2226@2 NA|NA|NA Q methyltransferase OLIIENHM_01719 1440774.Y900_013605 7.6e-49 199.9 Mycobacteriaceae 4.4.1.5 ko:K01759,ko:K08234 ko00620,map00620 R02530 RC00004,RC00740 ko00000,ko00001,ko01000 Bacteria 238XA@1762,2IIYW@201174,COG0346@1,COG0346@2 NA|NA|NA E Glyoxalase bleomycin resistance protein dioxygenase OLIIENHM_01720 1440774.Y900_013595 5e-55 220.7 Mycobacteriaceae Bacteria 238KG@1762,2IJGW@201174,COG4044@1,COG4044@2 NA|NA|NA S May play a role in the intracellular transport of hydrophobic ligands OLIIENHM_01721 1440774.Y900_013590 2.2e-192 678.3 Mycobacteriaceae lipE Bacteria 235DV@1762,2GJJB@201174,COG1680@1,COG1680@2 NA|NA|NA V beta-lactamase OLIIENHM_01722 47839.CCAU010000002_gene2406 5.5e-25 120.2 Mycobacteriaceae Bacteria 23A5Q@1762,2AUU9@1,2IKTE@201174,31KHD@2 NA|NA|NA S Protein of unknown function (DUF2694) OLIIENHM_01723 1440774.Y900_013575 1.2e-28 132.5 Mycobacteriaceae Bacteria 23A43@1762,2AVCJ@1,2IMMI@201174,31M40@2 NA|NA|NA S Excreted virulence factor EspC, type VII ESX diderm OLIIENHM_01724 931627.MycrhDRAFT_2359 1e-73 284.3 Mycobacteriaceae Bacteria 234NI@1762,2ATF1@1,2IAF1@201174,31IYH@2 NA|NA|NA S Domain of unknown function (DUF4226) OLIIENHM_01725 1440774.Y900_013565 1.1e-14 86.3 Mycobacteriaceae Bacteria 23AN4@1762,2BA8J@1,2IR1P@201174,323NN@2 NA|NA|NA S Domain of unknown function (DUF4226) OLIIENHM_01726 931627.MycrhDRAFT_2357 3.1e-70 271.9 Mycobacteriaceae ko:K21471 ko00000,ko01000,ko01002,ko01011 Bacteria 233PC@1762,2GIWB@201174,COG0791@1,COG0791@2 NA|NA|NA M NlpC/P60 family OLIIENHM_01727 1440774.Y900_013555 9.7e-87 326.6 Mycobacteriaceae exsI Bacteria 233FD@1762,2GMSM@201174,COG1396@1,COG1396@2 NA|NA|NA K Helix-turn-helix OLIIENHM_01728 931627.MycrhDRAFT_2355 6.1e-54 216.9 Mycobacteriaceae whiB5 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 ko:K18956 ko00000,ko03000 Bacteria 238RJ@1762,2AU18@1,2IJK9@201174,31JMD@2 NA|NA|NA K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA OLIIENHM_01729 1440774.Y900_013535 1.2e-08 65.9 Mycobacteriaceae Bacteria 23E4M@1762,2BSE9@1,2H9KE@201174,32MG8@2 NA|NA|NA OLIIENHM_01730 1078020.KEK_00140 4.2e-131 474.6 Mycobacteriaceae Bacteria 232BS@1762,2I8YI@201174,COG3173@1,COG3173@2 NA|NA|NA S Aminoglycoside phosphotransferase OLIIENHM_01731 931627.MycrhDRAFT_2347 3.4e-138 497.7 Mycobacteriaceae ko:K14250 ko00253,ko01057,ko01130,map00253,map01057,map01130 M00778 R09188,R09325,R09326,R09350 RC02459,RC02512,RC02517 ko00000,ko00001,ko00002 Bacteria 237KJ@1762,2ICNS@201174,COG1878@1,COG1878@2 NA|NA|NA S Putative cyclase OLIIENHM_01732 350058.Mvan_4726 2.9e-111 409.1 Mycobacteriaceae Bacteria 233V6@1762,2GNAQ@201174,COG5651@1,COG5651@2 NA|NA|NA N PFAM PE-PPE, C-terminal OLIIENHM_01733 1440774.Y900_013505 6.4e-26 123.2 Mycobacteriaceae Bacteria 23DYD@1762,2B8SA@1,2H6AF@201174,32229@2 NA|NA|NA OLIIENHM_01734 65393.PCC7424_0224 5e-94 350.9 Cyanothece Bacteria 1GM77@1117,3KJP1@43988,COG1028@1,COG1028@2 NA|NA|NA IQ KR domain OLIIENHM_01735 459495.SPLC1_S100020 2.9e-105 388.3 Oscillatoriales Bacteria 1GDYH@1117,1HFPG@1150,COG1028@1,COG1028@2 NA|NA|NA IQ Enoyl-(Acyl carrier protein) reductase OLIIENHM_01736 68170.KL590520_gene7986 1.6e-42 180.3 Pseudonocardiales 1.14.13.127 ko:K05712 ko00360,ko01120,ko01220,map00360,map01120,map01220 M00545 R06786,R06787 RC00236 ko00000,ko00001,ko00002,ko01000 Bacteria 2IBV0@201174,4EBIE@85010,COG0654@1,COG0654@2 NA|NA|NA CH FAD binding domain OLIIENHM_01737 1123229.AUBC01000013_gene2547 5e-41 174.9 Alphaproteobacteria 5.2.1.1 ko:K01799 ko00650,ko00760,ko01120,map00650,map00760,map01120 M00622 R01087 RC00448 ko00000,ko00001,ko00002,ko01000 Bacteria 1Q31P@1224,2U921@28211,COG3473@1,COG3473@2 NA|NA|NA Q Maleate cis-trans isomerase OLIIENHM_01738 543728.Vapar_0800 6.7e-83 314.7 Comamonadaceae Bacteria 1NQHH@1224,2W1RY@28216,4AHCP@80864,COG2079@1,COG2079@2 NA|NA|NA S MmgE/PrpD family OLIIENHM_01739 66429.JOFL01000001_gene4376 1.5e-96 359.4 Actinobacteria hemB GO:0000287,GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 iECABU_c1320.ECABU_c04500,iEcSMS35_1347.EcSMS35_0398,iJN746.PP_2913,ic_1306.c0477 Bacteria 2GJJ0@201174,COG0113@1,COG0113@2 NA|NA|NA H Belongs to the ALAD family OLIIENHM_01741 710687.KI912270_gene4412 1.3e-85 323.6 Mycobacteriaceae Bacteria 2363S@1762,2GNFI@201174,COG0583@1,COG0583@2 NA|NA|NA K TniQ OLIIENHM_01742 1123517.JOMR01000001_gene86 1.9e-49 202.2 Thiotrichales ftnA GO:0003674,GO:0003824,GO:0004322,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0008152,GO:0008199,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016491,GO:0016722,GO:0016724,GO:0019725,GO:0030003,GO:0033554,GO:0042221,GO:0042592,GO:0042802,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071241,GO:0071248,GO:0071281,GO:0097577,GO:0098771 1.16.3.2 ko:K02217,ko:K02255 ko00000,ko01000 Bacteria 1R9ZC@1224,1RYVB@1236,4617E@72273,COG1528@1,COG1528@2 NA|NA|NA P Iron-storage protein OLIIENHM_01743 1136417.AZWE01000058_gene298 6.5e-10 70.1 Micromonosporales feoA ko:K04758 ko00000,ko02000 Bacteria 2HV5M@201174,4DKGU@85008,COG1918@1,COG1918@2 NA|NA|NA P FeoA OLIIENHM_01744 47839.CCAU010000007_gene2138 2.5e-179 635.6 Mycobacteriaceae feoB ko:K04759 ko00000,ko02000 9.A.8.1 Bacteria 235FD@1762,2GTV2@201174,COG0370@1,COG0370@2 NA|NA|NA P Ferrous iron transport protein B C terminus OLIIENHM_01746 426117.M446_6397 2.6e-48 198.7 Methylobacteriaceae uidR Bacteria 1JXM7@119045,1MVQV@1224,2TRPA@28211,COG1309@1,COG1309@2 NA|NA|NA K PFAM regulatory protein TetR OLIIENHM_01747 234267.Acid_6736 7.3e-145 520.8 Bacteria pcpB Bacteria COG0654@1,COG0654@2 NA|NA|NA CH COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases OLIIENHM_01748 1299327.I546_1323 1.3e-62 246.1 Mycobacteriaceae 2.1.1.67 ko:K00569 ko00983,map00983 R08236,R08239,R08246 RC00003,RC00980,RC02277 ko00000,ko00001,ko01000 Bacteria 23F6D@1762,2GX4K@201174,COG0500@1,COG0500@2 NA|NA|NA Q Tellurite resistance protein TehB OLIIENHM_01749 318424.EU78_27145 3.2e-102 378.3 Mycobacteriaceae Bacteria 2344M@1762,2I1UA@201174,COG0204@1,COG0204@2 NA|NA|NA I Glycerol acyltransferase OLIIENHM_01750 318424.EU78_27150 1.6e-87 329.3 Mycobacteriaceae Bacteria 236BX@1762,2IBZK@201174,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family OLIIENHM_01751 318424.EU78_04470 3.8e-150 537.7 Mycobacteriaceae 1.1.1.1,1.1.1.14 ko:K00001,ko:K00008 ko00010,ko00040,ko00051,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00040,map00051,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 M00014 R00623,R00754,R00875,R01896,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00085,RC00087,RC00088,RC00099,RC00102,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko00002,ko01000 Bacteria 2384Z@1762,2GNS1@201174,COG1063@1,COG1063@2 NA|NA|NA E alcohol dehydrogenase OLIIENHM_01752 1174684.EBMC1_03764 1.8e-35 155.2 Sphingomonadales Bacteria 1N4F0@1224,2DRRT@1,2K7DV@204457,2UECN@28211,32URI@2 NA|NA|NA OLIIENHM_01753 1209984.BN978_01475 7.5e-35 153.7 Mycobacteriaceae 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 23A4I@1762,2GR9E@201174,COG1008@1,COG1008@2 NA|NA|NA C 2TM domain OLIIENHM_01754 1370125.AUWT01000074_gene2668 2.5e-209 734.9 Mycobacteriaceae Bacteria 234KQ@1762,2GIUM@201174,COG0477@1,COG0477@2 NA|NA|NA EGP Major facilitator superfamily OLIIENHM_01755 318424.EU78_20400 2.9e-76 291.6 Mycobacteriaceae Bacteria 23928@1762,2IMN5@201174,COG1309@1,COG1309@2 NA|NA|NA K WHG domain OLIIENHM_01756 1370121.AUWS01000011_gene6186 2.3e-36 158.7 Mycobacteriaceae Bacteria 239FD@1762,2GSTR@201174,COG3871@1,COG3871@2 NA|NA|NA S Pyridoxamine 5'-phosphate oxidase OLIIENHM_01757 931627.MycrhDRAFT_3221 3.4e-28 131.0 Mycobacteriaceae Bacteria 23AR4@1762,2E7QJ@1,2GR2A@201174,33260@2 NA|NA|NA S Protein of unknown function (DUF3349) OLIIENHM_01758 931627.MycrhDRAFT_3220 3.5e-37 160.6 Mycobacteriaceae Bacteria 23AJS@1762,2EGF0@1,2IS8P@201174,33I9S@2 NA|NA|NA OLIIENHM_01759 1440774.Y900_017060 2.7e-190 671.4 Mycobacteriaceae pit ko:K03306 ko00000 2.A.20 Bacteria 234S8@1762,2GJHK@201174,COG0306@1,COG0306@2 NA|NA|NA P phosphate transporter OLIIENHM_01760 1440774.Y900_004055 1.6e-95 355.9 Mycobacteriaceae plsC 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 234EG@1762,2GJBQ@201174,COG0204@1,COG0204@2 NA|NA|NA I Acyltransferase OLIIENHM_01761 931627.MycrhDRAFT_1827 5e-116 424.1 Mycobacteriaceae Bacteria 232SA@1762,2GKKH@201174,COG3176@1,COG3176@2 NA|NA|NA S Acetyltransferase (GNAT) domain OLIIENHM_01762 931627.MycrhDRAFT_6767 1.6e-29 135.2 Mycobacteriaceae blaI GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042221,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 Bacteria 238MF@1762,2IIIT@201174,COG3682@1,COG3682@2 NA|NA|NA K Transcriptional regulator OLIIENHM_01764 1172186.KB911463_gene3648 3.2e-32 144.4 Mycobacteriaceae rho 3.1.26.12 ko:K03110,ko:K03628,ko:K03642,ko:K03646,ko:K07184,ko:K08300 ko02024,ko03018,ko03060,ko03070,map02024,map03018,map03060,map03070 M00335,M00394 ko00000,ko00001,ko00002,ko01000,ko02000,ko02044,ko03009,ko03019,ko03021 2.C.1.2,3.A.5.1,3.A.5.2,3.A.5.7 Bacteria 23FBN@1762,2I5M1@201174,COG3064@1,COG3064@2,COG3103@1,COG3103@2 NA|NA|NA MT Membrane OLIIENHM_01765 1123258.AQXZ01000019_gene2778 4.4e-106 391.0 Actinobacteria Bacteria 2DM8B@1,2H4GE@201174,325JJ@2 NA|NA|NA S Protein of unknown function (DUF2804) OLIIENHM_01766 419947.MRA_1183 7.7e-16 91.7 Bacteria 3.1.1.3 ko:K01046 ko00561,ko01100,map00561,map01100 M00098 R02250,R02687 RC00020,RC00037,RC00041,RC00094 ko00000,ko00001,ko00002,ko01000 Bacteria COG0657@1,COG0657@2 NA|NA|NA I acetylesterase activity OLIIENHM_01767 1265310.CCBD010000068_gene587 5e-81 307.8 Mycobacteriaceae Bacteria 23A5A@1762,2ADT6@1,2IP77@201174,313IT@2 NA|NA|NA OLIIENHM_01768 1078020.KEK_12418 9.3e-08 63.2 Mycobacteriaceae Bacteria 234YC@1762,2AMYC@1,2I99N@201174,31CVF@2 NA|NA|NA OLIIENHM_01769 1451261.AS96_12320 4.7e-116 425.2 Microbacteriaceae Bacteria 2GJVW@201174,4FM0R@85023,COG1574@1,COG1574@2 NA|NA|NA S Amidohydrolase family OLIIENHM_01770 497321.C664_13674 7e-33 146.7 Rhodocyclales Bacteria 1N02U@1224,2CNK3@1,2KX0T@206389,2VUNW@28216,32SH9@2 NA|NA|NA S Protein of Unknown function (DUF2784) OLIIENHM_01771 221360.RS9917_05220 5.1e-224 783.9 Synechococcus ipdC 4.1.1.74 ko:K04103 ko00380,ko01100,map00380,map01100 R01974 RC00506 ko00000,ko00001,ko01000 Bacteria 1G1A5@1117,1H019@1129,COG3961@1,COG3961@2 NA|NA|NA GH Belongs to the TPP enzyme family OLIIENHM_01772 1108045.GORHZ_164_00400 0.0 1381.3 Gordoniaceae cdr ko:K04085 ko04122,map04122 ko00000,ko00001,ko01000,ko03016 Bacteria 2H7WY@201174,4GCJ9@85026,COG0446@1,COG0446@2,COG0607@1,COG0607@2,COG2210@1,COG2210@2 NA|NA|NA P Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain OLIIENHM_01773 931627.MycrhDRAFT_3306 1.1e-17 99.8 Mycobacteriaceae Bacteria 23D1P@1762,2BNA7@1,2H3TI@201174,32GXR@2 NA|NA|NA OLIIENHM_01774 350058.Mvan_1070 9.5e-34 149.8 Mycobacteriaceae Bacteria 2393T@1762,2ADMH@1,2II86@201174,313C7@2 NA|NA|NA OLIIENHM_01776 1123258.AQXZ01000019_gene3031 6.4e-13 79.3 Nocardiaceae Bacteria 2EIY8@1,2HXVY@201174,31WER@2,4G8FM@85025 NA|NA|NA OLIIENHM_01777 1209984.BN978_07090 2.6e-189 668.3 Mycobacteriaceae ndh 1.6.99.3 ko:K03885 ko00190,map00190 ko00000,ko00001,ko01000 Bacteria 23533@1762,2GJFE@201174,COG1252@1,COG1252@2 NA|NA|NA C Pyridine nucleotide-disulphide oxidoreductase OLIIENHM_01778 1440774.Y900_010130 1.2e-14 86.3 Mycobacteriaceae Bacteria 23BBQ@1762,2AU36@1,2GV9U@201174,31VAF@2 NA|NA|NA OLIIENHM_01780 525368.HMPREF0591_5966 0.0 1234.9 Mycobacteriaceae ctpF GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.8 ko:K01537,ko:K12953 ko00000,ko01000 3.A.3,3.A.3.2 Bacteria 232MQ@1762,2GJJC@201174,COG0474@1,COG0474@2 NA|NA|NA P ATPase, P-type (transporting), HAD superfamily, subfamily IC OLIIENHM_01781 557599.MKAN_02890 7.8e-72 277.3 Actinobacteria uspA Bacteria 2INFQ@201174,COG0589@1,COG0589@2 NA|NA|NA T Universal stress protein OLIIENHM_01782 557599.MKAN_02885 3.9e-240 837.4 Mycobacteriaceae MA20_07375 Bacteria 234RP@1762,2I8V5@201174,COG1226@1,COG1226@2,COG4651@1,COG4651@2 NA|NA|NA P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family OLIIENHM_01783 472759.Nhal_3098 1.8e-77 296.6 Gammaproteobacteria ko:K03294 ko00000 2.A.3.2 Bacteria 1MXNJ@1224,1RMKV@1236,COG0531@1,COG0531@2 NA|NA|NA E Amino Acid OLIIENHM_01784 931627.MycrhDRAFT_0004 2.4e-168 599.4 Mycobacteriaceae Bacteria 2343H@1762,2I5V8@201174,COG1506@1,COG1506@2 NA|NA|NA E peptidase S15 OLIIENHM_01785 1137271.AZUM01000007_gene3354 1.2e-53 216.5 Actinobacteria ko:K03281 ko00000 2.A.49 Bacteria 2IP0V@201174,COG0589@1,COG0589@2 NA|NA|NA T Belongs to the universal stress protein A family OLIIENHM_01786 557599.MKAN_18555 3e-87 328.6 Mycobacteriaceae Bacteria 233J9@1762,2ICPM@201174,COG0589@1,COG0589@2 NA|NA|NA T Universal stress protein OLIIENHM_01787 710687.KI912270_gene5441 2.5e-152 545.0 Mycobacteriaceae Bacteria 23D63@1762,2I90H@201174,COG4307@1,COG4307@2 NA|NA|NA S Putative zinc-binding metallo-peptidase OLIIENHM_01788 47839.CCAU010000016_gene4371 3.5e-191 674.5 Mycobacteriaceae cyp135B1 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0008150,GO:0008152,GO:0008202,GO:0016125,GO:0016491,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071704,GO:1901360,GO:1901615 1.14.14.1 ko:K00493 ko00071,ko00380,ko00627,ko01120,map00071,map00380,map00627,map01120 R03629,R04121,R05259 RC00046,RC01311 ko00000,ko00001,ko01000 Bacteria 233IE@1762,2GK4Z@201174,COG2124@1,COG2124@2 NA|NA|NA C cytochrome p450 OLIIENHM_01789 318424.EU78_25440 1.7e-66 259.2 Mycobacteriaceae Bacteria 2399Z@1762,2IFH7@201174,COG2304@1,COG2304@2 NA|NA|NA S von Willebrand factor (vWF) type A domain OLIIENHM_01790 1440774.Y900_008670 6.4e-93 347.4 Mycobacteriaceae ko:K07058 ko00000 Bacteria 2371H@1762,2GKV0@201174,COG1295@1,COG1295@2 NA|NA|NA S ribonuclease BN OLIIENHM_01791 1120948.KB903217_gene1506 1.4e-13 81.6 Bacteria ko:K05337 ko00000 Bacteria COG1141@1,COG1141@2 NA|NA|NA C electron transfer activity OLIIENHM_01792 110319.CF8_1832 3.6e-169 601.3 Propionibacteriales Bacteria 2GKCG@201174,4DP4U@85009,COG2124@1,COG2124@2 NA|NA|NA Q Cytochrome P450 OLIIENHM_01793 110319.CF8_1831 1.1e-33 150.2 Actinobacteria Bacteria 2GMDA@201174,COG1309@1,COG1309@2 NA|NA|NA K transcriptional regulator OLIIENHM_01794 1122951.ATUE01000005_gene2179 1e-88 334.0 Bacteria Bacteria 2F107@1,33RPE@2 NA|NA|NA OLIIENHM_01795 1206726.BAFV01000018_gene1079 1.8e-20 106.3 Nocardiaceae Bacteria 2APEJ@1,2HHZN@201174,31EH7@2,4G1WT@85025 NA|NA|NA OLIIENHM_01797 1440774.Y900_014415 2.6e-132 478.4 Mycobacteriaceae ldh 1.1.1.27,1.1.1.37 ko:K00016,ko:K00024 ko00010,ko00020,ko00270,ko00620,ko00630,ko00640,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04922,map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200,map04922 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R00703,R01000,R03104,R07136 RC00031,RC00044 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 237AP@1762,2GN5S@201174,COG0039@1,COG0039@2 NA|NA|NA C Belongs to the LDH MDH superfamily OLIIENHM_01798 1408452.JAGZ01000011_gene375 1.7e-78 299.3 Actinobacteria dnrD ko:K01420,ko:K21563 ko00000,ko03000 Bacteria 2GQ2Y@201174,COG0664@1,COG0664@2 NA|NA|NA K Crp-like helix-turn-helix domain OLIIENHM_01799 1192124.LIG30_1364 1.6e-214 752.3 Burkholderiaceae hcp GO:0000302,GO:0001505,GO:0003674,GO:0003824,GO:0004601,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016661,GO:0016684,GO:0017144,GO:0034641,GO:0042133,GO:0042135,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0044237,GO:0044248,GO:0044270,GO:0046209,GO:0046210,GO:0046677,GO:0050418,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1990748,GO:2001057 1.7.99.1 ko:K05601 ko00910,map00910 R00143 RC02797 ko00000,ko00001,ko01000 Bacteria 1K2Y7@119060,1N88B@1224,2VNCJ@28216,COG0369@1,COG1151@2 NA|NA|NA C Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O OLIIENHM_01800 469371.Tbis_0140 2.1e-87 329.3 Pseudonocardiales benC GO:0003674,GO:0003824,GO:0004497,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009507,GO:0009536,GO:0009987,GO:0015049,GO:0015050,GO:0015947,GO:0016491,GO:0016705,GO:0016709,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043446,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071704,GO:1902494 1.14.13.25 ko:K02823,ko:K05784,ko:K11311,ko:K16161 ko00240,ko00362,ko00364,ko00622,ko00627,ko00680,ko01100,ko01120,ko01200,ko01220,map00240,map00362,map00364,map00622,map00627,map00680,map01100,map01120,map01200,map01220 M00174,M00551,M00637 R00823,R00825,R01142,R05290,R05291,R05428,R05621,R05622,R05665,R08100,R08101,R08108,R08109,R08110 RC00173,RC00192,RC00270,RC01378,RC01450,RC01910 br01602,ko00000,ko00001,ko00002,ko01000 Bacteria 2I3N3@201174,4DYIS@85010,COG0543@1,COG0543@2,COG1018@1,COG1018@2 NA|NA|NA C Oxidoreductase FAD-binding domain OLIIENHM_01801 441620.Mpop_0711 3.1e-07 62.0 Methylobacteriaceae Bacteria 1JV85@119045,1NVU2@1224,2DMDI@1,2US9B@28211,32Q2W@2 NA|NA|NA OLIIENHM_01802 1151118.KB895786_gene2296 1.7e-16 92.4 Actinobacteria Bacteria 2ER8S@1,2H0KQ@201174,33IUC@2 NA|NA|NA OLIIENHM_01804 452652.KSE_72570 7.7e-101 374.4 Kitasatospora pqrB ko:K08167 M00713,M00714 ko00000,ko00002,ko01504,ko02000 2.A.1.3 Bacteria 2GIUM@201174,2M06T@2063,COG0477@1,COG0477@2 NA|NA|NA EGP Major Facilitator Superfamily OLIIENHM_01805 44454.NF84_22565 1.2e-73 283.1 Mycobacteriaceae ycgQ ko:K08986 ko00000 Bacteria 235B2@1762,2GNFK@201174,COG3689@1,COG3689@2 NA|NA|NA S Domain of unknown function (DUF1980) OLIIENHM_01806 1157943.KB892705_gene3907 6.6e-115 420.6 Mycobacteriaceae ycgR ko:K07089 ko00000 Bacteria 236C3@1762,2GJQ0@201174,COG0701@1,COG0701@2 NA|NA|NA S Predicted permease OLIIENHM_01807 350058.Mvan_4048 8.2e-165 587.0 Mycobacteriaceae Bacteria 2349Y@1762,2GK5U@201174,COG0277@1,COG0277@2 NA|NA|NA C oxidoreductase OLIIENHM_01808 931627.MycrhDRAFT_2155 1.2e-112 412.9 Mycobacteriaceae 2.7.1.72 ko:K04343 M00766 R02225 RC00002,RC00078 br01600,ko00000,ko00002,ko01000,ko01504 Bacteria 234XA@1762,2GNSH@201174,COG3570@1,COG3570@2 NA|NA|NA V aminoglycoside hydroxyurea antibiotic resistance kinase OLIIENHM_01809 44454.NF84_08880 1e-43 183.3 Mycobacteriaceae ko:K18481 M00670 ko00000,ko00002,ko02000 3.A.1.27.4,3.A.1.27.5 Bacteria 236KI@1762,2E5BU@1,2IFCH@201174,3303V@2 NA|NA|NA OLIIENHM_01810 710686.Mycsm_05002 7.2e-46 190.7 Mycobacteriaceae ko:K18481 M00670 ko00000,ko00002,ko02000 3.A.1.27.4,3.A.1.27.5 Bacteria 238VW@1762,2IG0F@201174,COG0443@1,COG0443@2 NA|NA|NA O Heat shock 70 kDa protein OLIIENHM_01811 350054.Mflv_4522 4.4e-107 394.8 Mycobacteriaceae ko:K02030 M00236 ko00000,ko00002,ko02000 3.A.1.3 Bacteria 2378A@1762,2H3I1@201174,COG0834@1,COG0834@2 NA|NA|NA P ABC transporter substrate-binding protein OLIIENHM_01812 931627.MycrhDRAFT_6778 2.8e-33 147.9 Mycobacteriaceae Bacteria 23DWJ@1762,2B0SN@1,2H69S@201174,3221X@2 NA|NA|NA OLIIENHM_01813 1298864.AUEQ01000008_gene2262 4.5e-39 167.2 Mycobacteriaceae Bacteria 238K1@1762,2IHEB@201174,COG5479@1,COG5479@2 NA|NA|NA M LGFP repeat OLIIENHM_01814 931627.MycrhDRAFT_1333 3.3e-121 442.2 Mycobacteriaceae hpx Bacteria 233ZC@1762,2GJSU@201174,COG2267@1,COG2267@2 NA|NA|NA I Alpha beta hydrolase OLIIENHM_01815 1440774.Y900_005770 1.3e-190 672.5 Mycobacteriaceae aofH GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.4.3.4 ko:K00274 ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034 M00135 R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354 RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713 ko00000,ko00001,ko00002,ko01000 Bacteria 236BJ@1762,2GK23@201174,COG1231@1,COG1231@2 NA|NA|NA E (mono)amine oxidase OLIIENHM_01816 931627.MycrhDRAFT_1337 2.1e-153 548.5 Mycobacteriaceae Bacteria 234QW@1762,2GNE9@201174,COG2141@1,COG2141@2 NA|NA|NA C F420-dependent oxidoreductase OLIIENHM_01817 1078020.KEK_10598 9.3e-46 190.3 Actinobacteria Bacteria 2INRS@201174,COG3548@1,COG3548@2 NA|NA|NA S Protein of unknown function (DUF1211) OLIIENHM_01818 1440774.Y900_005760 2.3e-196 691.4 Mycobacteriaceae Bacteria 233DJ@1762,2BYTM@1,2GJ6K@201174,2Z7KC@2 NA|NA|NA OLIIENHM_01819 1440774.Y900_005755 1.2e-181 642.5 Mycobacteriaceae Bacteria 233HC@1762,2GSTN@201174,COG3173@1,COG3173@2 NA|NA|NA S Aminoglycoside phosphotransferase OLIIENHM_01820 1122247.C731_1412 2.5e-72 278.5 Mycobacteriaceae Bacteria 2367I@1762,2GNK4@201174,COG1309@1,COG1309@2 NA|NA|NA K tetR family OLIIENHM_01821 1440774.Y900_005745 2.6e-112 411.8 Mycobacteriaceae 1.1.1.100,1.1.1.401 ko:K00059,ko:K07124,ko:K21883 ko00051,ko00061,ko00333,ko00780,ko01040,ko01100,ko01120,ko01130,ko01212,map00051,map00061,map00333,map00780,map01040,map01100,map01120,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11339,R11671 RC00029,RC00089,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 236JZ@1762,2IEPP@201174,COG0300@1,COG0300@2 NA|NA|NA S Belongs to the short-chain dehydrogenases reductases (SDR) family OLIIENHM_01822 463191.SSEG_04922 2.5e-46 192.2 Actinobacteria Bacteria 2ICN9@201174,COG1309@1,COG1309@2 NA|NA|NA K Transcriptional regulator OLIIENHM_01823 262316.MAP_1317c 1.1e-56 226.5 Mycobacteriaceae Bacteria 237S5@1762,2H3AT@201174,COG3247@1,COG3247@2 NA|NA|NA S Short repeat of unknown function (DUF308) OLIIENHM_01824 1120797.KB908261_gene76 6e-178 630.6 Mycobacteriaceae Bacteria 235RE@1762,2GKEK@201174,COG4320@1,COG4320@2 NA|NA|NA S Uncharacterized protein conserved in bacteria (DUF2252) OLIIENHM_01825 1370121.AUWS01000064_gene435 1.5e-27 128.6 Actinobacteria Bacteria 2E7QZ@1,2GR1A@201174,3326A@2 NA|NA|NA S Stress responsive A/B Barrel Domain OLIIENHM_01826 1440774.Y900_005735 7.9e-100 370.2 Mycobacteriaceae Bacteria 232KU@1762,2GN69@201174,COG1024@1,COG1024@2 NA|NA|NA I Enoyl-CoA hydratase OLIIENHM_01827 931627.MycrhDRAFT_1344 9.9e-206 723.0 Mycobacteriaceae nuoN GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2358Z@1762,2GMGX@201174,COG1007@1,COG1007@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient OLIIENHM_01828 931627.MycrhDRAFT_1345 5.8e-230 803.5 Mycobacteriaceae nuoM GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0048037,GO:0048038,GO:0048039,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1902600,GO:1990204 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 iSDY_1059.SDY_2473 Bacteria 232NQ@1762,2GKBN@201174,COG1008@1,COG1008@2 NA|NA|NA C oxidoreductase, chain M OLIIENHM_01829 931627.MycrhDRAFT_1346 1.9e-280 971.5 Mycobacteriaceae nuoL GO:0008150,GO:0009605,GO:0009607,GO:0043207,GO:0044403,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0075136 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 232IE@1762,2GIT4@201174,COG1009@1,COG1009@2 NA|NA|NA CP oxidoreductase chain L OLIIENHM_01830 931627.MycrhDRAFT_1347 4e-39 167.2 Mycobacteriaceae nuoK GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3 ko:K00340,ko:K05576 ko00190,ko01100,map00190,map01100 M00144,M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 239X0@1762,2IKV7@201174,COG0713@1,COG0713@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient OLIIENHM_01831 1440774.Y900_005710 7.4e-89 333.6 Mycobacteriaceae nuoJ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 233A9@1762,2GKRS@201174,COG0839@1,COG0839@2 NA|NA|NA C Belongs to the complex I subunit 6 family OLIIENHM_01832 318424.EU78_08545 2.1e-20 104.4 Mycobacteriaceae nuoI 1.6.5.3 ko:K00337,ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2347T@1762,2GJNU@201174,COG1143@1,COG1143@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient OLIIENHM_01834 931627.MycrhDRAFT_0619 3e-97 361.7 Mycobacteriaceae Bacteria 234FV@1762,2GM7Q@201174,COG0739@1,COG0739@2 NA|NA|NA M peptidase OLIIENHM_01835 1440774.Y900_008365 1.5e-39 169.1 Mycobacteriaceae Bacteria 239KX@1762,2ANS5@1,2IBE7@201174,31DS3@2 NA|NA|NA OLIIENHM_01836 931627.MycrhDRAFT_0617 0.0 1308.5 Mycobacteriaceae pcrA GO:0000018,GO:0000166,GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030312,GO:0030554,GO:0031323,GO:0031324,GO:0032392,GO:0032508,GO:0032552,GO:0032554,GO:0032558,GO:0032564,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0036094,GO:0040007,GO:0042623,GO:0043138,GO:0043140,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0045910,GO:0045934,GO:0046483,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 235EQ@1762,2GISS@201174,COG0210@1,COG0210@2 NA|NA|NA L ATP-dependent DNA helicase OLIIENHM_01837 1440774.Y900_008375 2.6e-31 141.0 Mycobacteriaceae tyrA GO:0000166,GO:0003674,GO:0003824,GO:0004106,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0071944,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 1.3.1.12,5.4.99.5 ko:K00210,ko:K04092,ko:K04093,ko:K14187 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00024,M00025 R01715,R01728 RC00125,RC03116 ko00000,ko00001,ko00002,ko01000 iECUMN_1333.ECUMN_2925 Bacteria 23AJ3@1762,2IQ8K@201174,COG1605@1,COG1605@2 NA|NA|NA E chorismate mutase OLIIENHM_01838 931627.MycrhDRAFT_0613 4.2e-235 820.5 Mycobacteriaceae gabD4 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 Bacteria 233TQ@1762,2GIWZ@201174,COG1012@1,COG1012@2 NA|NA|NA C Belongs to the aldehyde dehydrogenase family OLIIENHM_01839 1440774.Y900_008400 6.6e-285 986.1 Mycobacteriaceae pgi GO:0003674,GO:0003824,GO:0004347,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 233EI@1762,2GJG0@201174,COG0166@1,COG0166@2 NA|NA|NA G Belongs to the GPI family OLIIENHM_01841 44454.NF84_04645 3.5e-108 397.9 Mycobacteriaceae Bacteria 233BP@1762,2I461@201174,COG4221@1,COG4221@2 NA|NA|NA S Belongs to the short-chain dehydrogenases reductases (SDR) family OLIIENHM_01842 1150599.MPHLEI_20869 3e-132 478.0 Mycobacteriaceae fpg 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 233H2@1762,2GKAM@201174,COG0266@1,COG0266@2 NA|NA|NA L Belongs to the FPG family OLIIENHM_01843 1440774.Y900_008415 1.8e-50 205.3 Mycobacteriaceae yvlD ko:K08972 ko00000 Bacteria 2397Q@1762,2IHP5@201174,COG1950@1,COG1950@2 NA|NA|NA S membrane OLIIENHM_01844 1172186.KB911462_gene414 1.3e-115 422.5 Mycobacteriaceae cobF 2.1.1.130,2.1.1.151,2.1.1.152 ko:K02228,ko:K03394 ko00860,ko01100,map00860,map01100 R03948,R05219,R05808 RC00003,RC00923,RC01035,RC01662,RC02890 ko00000,ko00001,ko01000 Bacteria 232JI@1762,2GJFA@201174,COG2243@1,COG2243@2 NA|NA|NA H synthase OLIIENHM_01845 931627.MycrhDRAFT_0607 1.1e-164 586.3 Mycobacteriaceae Bacteria 23FA0@1762,2I5AX@201174,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily OLIIENHM_01846 931627.MycrhDRAFT_0606 4.5e-308 1063.5 Mycobacteriaceae cadA Bacteria 235KJ@1762,2GIRF@201174,COG2217@1,COG2217@2 NA|NA|NA P heavy metal translocating P-type ATPase OLIIENHM_01847 931627.MycrhDRAFT_0605 7.1e-46 190.3 Mycobacteriaceae Bacteria 2378K@1762,2DBEB@1,2IRDQ@201174,32TXC@2 NA|NA|NA OLIIENHM_01848 1440774.Y900_008440 3.4e-147 527.7 Mycobacteriaceae GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 234PV@1762,2H0K9@201174,COG2141@1,COG2141@2 NA|NA|NA C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases OLIIENHM_01849 931627.MycrhDRAFT_0601 0.0 1100.5 Mycobacteriaceae prpE 6.2.1.1,6.2.1.17 ko:K01895,ko:K01908 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 23529@1762,2GP7N@201174,COG0365@1,COG0365@2 NA|NA|NA I PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A OLIIENHM_01850 1440774.Y900_011630 8.1e-154 551.2 Mycobacteriaceae Bacteria 2343H@1762,2I5V8@201174,COG1506@1,COG1506@2 NA|NA|NA E peptidase S15 OLIIENHM_01851 931627.MycrhDRAFT_0597 0.0 1218.4 Mycobacteriaceae ligD GO:0000166,GO:0000287,GO:0000726,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0003896,GO:0003899,GO:0003909,GO:0003910,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0004652,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006269,GO:0006281,GO:0006302,GO:0006303,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016874,GO:0016886,GO:0016895,GO:0017076,GO:0018130,GO:0019438,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0033554,GO:0034061,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0070566,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0097747,GO:0140097,GO:0140098,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 ko:K01971,ko:K10747 ko03030,ko03410,ko03420,ko03430,ko03450,map03030,map03410,map03420,map03430,map03450 R00381,R00382,R10822,R10823 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 Bacteria 232ZK@1762,2GJPX@201174,COG1793@1,COG1793@2,COG3285@1,COG3285@2 NA|NA|NA L DNA ligase OLIIENHM_01852 931627.MycrhDRAFT_0595 7e-127 460.3 Mycobacteriaceae ku GO:0000726,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006303,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050790,GO:0050896,GO:0051340,GO:0051351,GO:0051716,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 ko:K10979 ko03450,map03450 ko00000,ko00001,ko03400 Bacteria 232DX@1762,2GJMU@201174,COG1273@1,COG1273@2 NA|NA|NA L With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD OLIIENHM_01853 931627.MycrhDRAFT_0594 5.3e-123 447.2 Mycobacteriaceae Bacteria 232EM@1762,2GJU1@201174,COG1028@1,COG1028@2 NA|NA|NA IQ Dehydrogenase OLIIENHM_01854 931627.MycrhDRAFT_0593 6.5e-172 610.1 Mycobacteriaceae 1.4.1.12,1.4.1.26 ko:K21672 ko00310,ko00330,ko00472,map00310,map00330,map00472 R02825,R04200,R04201,R04687,R04688 RC00249,RC00790 ko00000,ko00001,ko01000 Bacteria 232FQ@1762,2GKE3@201174,COG3804@1,COG3804@2 NA|NA|NA S dihydrodipicolinate reductase OLIIENHM_01855 710685.MycrhN_3270 1.5e-12 79.0 Mycobacteriaceae Bacteria 23BP2@1762,2DIAR@1,2GQHR@201174,302JT@2 NA|NA|NA OLIIENHM_01857 931627.MycrhDRAFT_0590 3.4e-169 601.3 Mycobacteriaceae mntH GO:0000041,GO:0003674,GO:0005215,GO:0005384,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0006826,GO:0006828,GO:0006829,GO:0008150,GO:0008324,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0015075,GO:0015077,GO:0015078,GO:0015086,GO:0015291,GO:0015292,GO:0015293,GO:0015318,GO:0015672,GO:0015684,GO:0015691,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0034220,GO:0034755,GO:0042221,GO:0044425,GO:0044464,GO:0046873,GO:0046915,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0070574,GO:0070838,GO:0070887,GO:0071241,GO:0071248,GO:0071281,GO:0071421,GO:0071577,GO:0071578,GO:0071944,GO:0072511,GO:0098655,GO:0098657,GO:0098659,GO:0098660,GO:0098662,GO:0098739,GO:0099587,GO:1902600 ko:K03322 ko00000,ko02000 2.A.55.2.6,2.A.55.3 iSF_1195.SF2457,iYO844.BSU04360 Bacteria 234PN@1762,2GJSM@201174,COG1914@1,COG1914@2 NA|NA|NA P H( )-stimulated, divalent metal cation uptake system OLIIENHM_01858 710685.MycrhN_3265 1.2e-66 260.0 Mycobacteriaceae 2.1.1.79 ko:K00574,ko:K09701 ko00000,ko01000 Bacteria 236MS@1762,2HBH1@201174,COG3496@1,COG3496@2 NA|NA|NA S Protein of unknown function (DUF1365) OLIIENHM_01859 1440774.Y900_008565 1.2e-78 299.3 Mycobacteriaceae sigK GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0010468,GO:0010565,GO:0016020,GO:0019216,GO:0019217,GO:0019222,GO:0030312,GO:0031323,GO:0044464,GO:0050789,GO:0050794,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090 ko:K03088 ko00000,ko03021 Bacteria 2371F@1762,2GP9D@201174,COG1595@1,COG1595@2 NA|NA|NA K Belongs to the sigma-70 factor family. ECF subfamily OLIIENHM_01860 1440774.Y900_008570 1.1e-85 323.2 Mycobacteriaceae rskA GO:0000988,GO:0000989,GO:0003674,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006417,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0010608,GO:0016020,GO:0016989,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0032268,GO:0034248,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141 Bacteria 235HJ@1762,2I8NI@201174,COG5343@1,COG5343@2 NA|NA|NA S An anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK. ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, Rip1), while cytoplasmic proteases finish degrading the regulatory protein, liberating the sigma factor OLIIENHM_01861 1440774.Y900_008575 2.4e-126 458.8 Mycobacteriaceae ko:K06048 ko00000,ko01000 Bacteria 234UU@1762,2GKAA@201174,COG2170@1,COG2170@2 NA|NA|NA S ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity OLIIENHM_01862 1440774.Y900_008580 7.5e-104 383.6 Mycobacteriaceae Bacteria 232F4@1762,2GMUE@201174,COG2141@1,COG2141@2 NA|NA|NA C Luciferase-like monooxygenase OLIIENHM_01864 931627.MycrhDRAFT_3614 7.1e-267 926.4 Mycobacteriaceae Bacteria 232SE@1762,2GMAT@201174,COG3250@1,COG3250@2 NA|NA|NA G Belongs to the glycosyl hydrolase 2 family OLIIENHM_01865 1435356.Y013_16795 1.1e-87 330.9 Nocardiaceae Bacteria 2GKU0@201174,4FXE2@85025,COG1020@1,COG1020@2 NA|NA|NA Q Protein of unknown function (DUF1298) OLIIENHM_01866 931627.MycrhDRAFT_0577 3.7e-208 730.7 Mycobacteriaceae 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 233H4@1762,2GIY0@201174,COG0183@1,COG0183@2 NA|NA|NA I Belongs to the thiolase family OLIIENHM_01867 1440774.Y900_008615 1e-271 942.2 Mycobacteriaceae ko:K11159 ko00000 Bacteria 235AD@1762,2GK7D@201174,COG3670@1,COG3670@2 NA|NA|NA Q dioxygenase OLIIENHM_01868 931627.MycrhDRAFT_0575 3.1e-106 391.7 Mycobacteriaceae Bacteria 2368M@1762,2GNVK@201174,COG1733@1,COG1733@2 NA|NA|NA K Transcriptional regulator OLIIENHM_01869 931627.MycrhDRAFT_0574 4e-60 238.0 Mycobacteriaceae Bacteria 238X0@1762,2AV2M@1,2IFK7@201174,31KSH@2 NA|NA|NA S Probable lipoprotein LpqN OLIIENHM_01870 931627.MycrhDRAFT_0571 1.3e-43 182.6 Mycobacteriaceae Bacteria 2399E@1762,2AKTG@1,2II8C@201174,31BKH@2 NA|NA|NA OLIIENHM_01871 931627.MycrhDRAFT_0567 3.2e-197 694.9 Mycobacteriaceae ko:K10716 ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 Bacteria 236EQ@1762,2GJS6@201174,COG1226@1,COG1226@2 NA|NA|NA P Ion channel OLIIENHM_01872 931627.MycrhDRAFT_0566 5.4e-140 503.8 Mycobacteriaceae ko:K07045 ko00000 Bacteria 235B7@1762,2GMQY@201174,COG2159@1,COG2159@2 NA|NA|NA S PFAM amidohydrolase OLIIENHM_01873 931627.MycrhDRAFT_0561 2.7e-63 248.1 Mycobacteriaceae GO:0008150,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0065007 Bacteria 238QK@1762,2IFGF@201174,COG3427@1,COG3427@2 NA|NA|NA S Polyketide cyclase / dehydrase and lipid transport OLIIENHM_01875 258533.BN977_01941 4.2e-115 421.0 Mycobacteriaceae ctpE GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 ko:K12952 ko00000,ko01000 3.A.3.23 Bacteria 2361Q@1762,2GJJC@201174,COG0474@1,COG0474@2 NA|NA|NA P ATPase, P-type (transporting), HAD superfamily, subfamily IC OLIIENHM_01876 931627.MycrhDRAFT_4229 9.3e-181 639.8 Mycobacteriaceae uspC ko:K02027 M00207 ko00000,ko00002,ko02000 3.A.1.1 iNJ661.Rv2318 Bacteria 2347X@1762,2GNJW@201174,COG1653@1,COG1653@2 NA|NA|NA G Bacterial extracellular solute-binding protein OLIIENHM_01877 1440774.Y900_022535 1.8e-118 432.2 Mycobacteriaceae uspB ko:K02026 M00207 ko00000,ko00002,ko02000 3.A.1.1 Bacteria 23425@1762,2GP5D@201174,COG0395@1,COG0395@2 NA|NA|NA P ABC transporter OLIIENHM_01878 931627.MycrhDRAFT_6425 2.8e-59 236.1 Mycobacteriaceae Bacteria 23BNW@1762,2GUMG@201174,COG5651@1,COG5651@2 NA|NA|NA N PE-PPE domain OLIIENHM_01879 1440774.Y900_022545 6.6e-247 859.8 Mycobacteriaceae tldD ko:K03568 ko00000,ko01002 Bacteria 23535@1762,2GJ4E@201174,COG0312@1,COG0312@2 NA|NA|NA S Modulator of DNA gyrase OLIIENHM_01880 1440774.Y900_022550 4e-211 740.7 Mycobacteriaceae tldD3 Bacteria 2329M@1762,2GZPS@201174,COG0312@1,COG0312@2 NA|NA|NA S Putative modulator of DNA gyrase OLIIENHM_01881 419947.MRA_2118 2.3e-27 127.9 Mycobacteriaceae Bacteria 23BKG@1762,2DSMH@1,2GR8G@201174,33GPM@2 NA|NA|NA OLIIENHM_01882 1380386.JIAW01000004_gene26 3.3e-58 231.1 Mycobacteriaceae GO:0005575,GO:0005576 ko:K07064 ko00000 Bacteria 239HU@1762,2IJ89@201174,COG1848@1,COG1848@2 NA|NA|NA S Toxic component of a toxin-antitoxin (TA) module. An RNase OLIIENHM_01884 216594.MMAR_3607 1e-146 526.6 Mycobacteriaceae ko:K07497 ko00000 Bacteria 23B3P@1762,2GTYQ@201174,COG0582@1,COG0582@2 NA|NA|NA L DNA integration. this sequence contains a DNA breaking-rejoining catalytic core found in phage integrase genes OLIIENHM_01887 35754.JNYJ01000036_gene3607 3.3e-88 332.0 Bacteria Bacteria COG1637@1,COG1637@2 NA|NA|NA L Cleaves both 3' and 5' ssDNA extremities of branched DNA structures OLIIENHM_01888 350054.Mflv_3199 0.0 1119.8 Mycobacteriaceae ko:K03724 ko00000,ko01000,ko03400 Bacteria 236WA@1762,2GK56@201174,COG1201@1,COG1201@2 NA|NA|NA L helicase superfamily c-terminal domain OLIIENHM_01889 1122247.C731_4982 2.9e-219 767.7 Mycobacteriaceae Bacteria 2354P@1762,2HM4W@201174,COG1474@1,COG1474@2 NA|NA|NA LO P-loop Domain of unknown function (DUF2791) OLIIENHM_01890 1209984.BN978_01100 1.1e-180 639.8 Mycobacteriaceae Bacteria 236VU@1762,2GK2R@201174,COG1524@1,COG1524@2 NA|NA|NA S PglZ domain OLIIENHM_01891 865937.Gilli_3252 8.2e-12 75.9 Flavobacteriia Bacteria 1I507@117743,2DI4K@1,3020V@2,4NV1J@976 NA|NA|NA S Protein of unknown function (DUF2892) OLIIENHM_01892 262316.MAP_0586c 1.6e-107 396.0 Mycobacteriaceae ko:K03194 ko03070,map03070 M00333 ko00000,ko00001,ko00002,ko02044 Bacteria 2359I@1762,2IBCH@201174,COG0741@1,COG0741@2 NA|NA|NA M transglycosylase OLIIENHM_01893 1440774.Y900_015570 1e-78 300.1 Mycobacteriaceae Bacteria 23CKH@1762,2B6DF@1,2H1XM@201174,31ZB9@2 NA|NA|NA S Sap, sulfolipid-1-addressing protein OLIIENHM_01894 1134474.O59_004100 1.8e-62 245.7 Cellvibrio ycaK 1.6.5.2 ko:K00355 ko00130,ko01110,ko05200,ko05225,ko05418,map00130,map01110,map05200,map05225,map05418 R02964,R03643,R03816 RC00819 ko00000,ko00001,ko01000 Bacteria 1FI5T@10,1RA5X@1224,1S3UT@1236,COG2249@1,COG2249@2 NA|NA|NA S Flavodoxin-like fold OLIIENHM_01895 1440774.Y900_015585 0.0 1103.2 Mycobacteriaceae dnaK GO:0000302,GO:0000303,GO:0000305,GO:0001968,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016020,GO:0016310,GO:0019222,GO:0019538,GO:0019899,GO:0030112,GO:0030162,GO:0030312,GO:0030313,GO:0031323,GO:0031325,GO:0031975,GO:0031982,GO:0032268,GO:0032270,GO:0033554,GO:0034599,GO:0034614,GO:0035375,GO:0036211,GO:0040007,GO:0042221,GO:0042603,GO:0043170,GO:0043226,GO:0043227,GO:0043230,GO:0043388,GO:0043412,GO:0044044,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046677,GO:0046688,GO:0046777,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051098,GO:0051099,GO:0051101,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0070613,GO:0070887,GO:0071450,GO:0071451,GO:0071704,GO:0071944,GO:0080090,GO:0097691,GO:1901564,GO:1901700,GO:1901701,GO:1903317,GO:1903319,GO:1903561,GO:2000677,GO:2000679 ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 Bacteria 2339Q@1762,2GJTY@201174,COG0443@1,COG0443@2 NA|NA|NA O Heat shock 70 kDa protein OLIIENHM_01896 1440774.Y900_015590 3.6e-68 264.6 Mycobacteriaceae grpE GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0007154,GO:0008150,GO:0009266,GO:0009267,GO:0009408,GO:0009605,GO:0009628,GO:0009986,GO:0009987,GO:0009991,GO:0016043,GO:0017076,GO:0019904,GO:0022607,GO:0030234,GO:0030246,GO:0030247,GO:0030312,GO:0030554,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0033554,GO:0036094,GO:0040007,GO:0042594,GO:0042802,GO:0042803,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0050790,GO:0050896,GO:0051082,GO:0051716,GO:0060589,GO:0060590,GO:0065003,GO:0065007,GO:0065009,GO:0071496,GO:0071840,GO:0071944,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065 ko:K02652,ko:K03687 ko00000,ko02035,ko02044,ko03029,ko03110 3.A.15.2 Bacteria 234P7@1762,2GP4F@201174,COG0576@1,COG0576@2 NA|NA|NA O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ OLIIENHM_01897 258533.BN977_04101 3e-162 578.2 Mycobacteriaceae dnaJ GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0010468,GO:0016020,GO:0019222,GO:0030312,GO:0040007,GO:0043388,GO:0044093,GO:0044464,GO:0050789,GO:0051098,GO:0051099,GO:0051101,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:2000677,GO:2000679 ko:K03686,ko:K05516 ko00000,ko03029,ko03036,ko03110 Bacteria 233BG@1762,2GJKK@201174,COG0484@1,COG0484@2 NA|NA|NA O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins OLIIENHM_01898 931627.MycrhDRAFT_2949 2.2e-47 194.9 Mycobacteriaceae hspR GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 ko:K13640 ko00000,ko03000 Bacteria 239CZ@1762,2IQJ4@201174,COG0789@1,COG0789@2 NA|NA|NA K transcriptional OLIIENHM_01899 1440774.Y900_015605 4.2e-132 477.6 Mycobacteriaceae 5.1.3.3 ko:K01785 ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130 M00632 R01602,R10619 RC00563 ko00000,ko00001,ko00002,ko01000 Bacteria 232CA@1762,2HMIG@201174,COG2017@1,COG2017@2 NA|NA|NA G Aldose 1-epimerase OLIIENHM_01900 1440774.Y900_015610 1.8e-26 124.8 Mycobacteriaceae Bacteria 23ANP@1762,2GR2W@201174,COG0236@1,COG0236@2 NA|NA|NA IQ acyl carrier protein OLIIENHM_01901 1440774.Y900_015615 1.3e-168 599.4 Mycobacteriaceae 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2377I@1762,2GN5J@201174,COG0508@1,COG0508@2 NA|NA|NA C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex OLIIENHM_01902 1440774.Y900_015620 2.6e-117 428.3 Mycobacteriaceae pdhA 1.2.4.1,1.2.4.4 ko:K00162,ko:K11381 ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00036,M00307 R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 233TJ@1762,2GKFE@201174,COG0022@1,COG0022@2 NA|NA|NA C Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase OLIIENHM_01903 350054.Mflv_4531 2.9e-40 171.0 Mycobacteriaceae Bacteria 239A9@1762,2ATP3@1,2IJ0T@201174,31J7P@2 NA|NA|NA OLIIENHM_01904 931627.MycrhDRAFT_4559 2.2e-40 171.8 Mycobacteriaceae Bacteria 23ADB@1762,2AVKT@1,2IM7D@201174,31KTJ@2 NA|NA|NA OLIIENHM_01905 931627.MycrhDRAFT_4528 2.7e-40 172.2 Mycobacteriaceae ko:K18481 M00670 ko00000,ko00002,ko02000 3.A.1.27.4,3.A.1.27.5 Bacteria 23644@1762,2E5BU@1,2GQEF@201174,343EN@2 NA|NA|NA OLIIENHM_01906 931627.MycrhDRAFT_4527 8e-45 187.2 Mycobacteriaceae dnaK GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K04043,ko:K18481 ko03018,ko04212,ko05152,map03018,map04212,map05152 M00670 ko00000,ko00001,ko00002,ko02000,ko03019,ko03029,ko03110,ko04147 1.A.33.1,3.A.1.27.4,3.A.1.27.5 Bacteria 238WM@1762,2IG0F@201174,COG0443@1,COG0443@2 NA|NA|NA O Heat shock 70 kDa protein OLIIENHM_01907 931627.MycrhDRAFT_4521 2.1e-140 505.4 Mycobacteriaceae GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 Bacteria 2337X@1762,2I8P3@201174,COG0778@1,COG0778@2 NA|NA|NA C nitroreductase OLIIENHM_01908 931627.MycrhDRAFT_4520 0.0 2100.9 Mycobacteriaceae pgmB GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005975,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008801,GO:0009292,GO:0009294,GO:0009987,GO:0016020,GO:0016787,GO:0016853,GO:0016866,GO:0016868,GO:0030312,GO:0033554,GO:0042221,GO:0043167,GO:0043169,GO:0044238,GO:0044464,GO:0044764,GO:0046677,GO:0046872,GO:0050896,GO:0051704,GO:0051716,GO:0071704,GO:0071944 2.4.1.216,2.4.1.64,2.4.1.8,3.1.3.12,3.2.1.28,5.4.2.6 ko:K00691,ko:K01087,ko:K01194,ko:K01838,ko:K03731,ko:K05342 ko00500,ko01100,map00500,map01100 R00010,R01555,R02727,R02728,R02778,R11310 RC00017,RC00049,RC00408 ko00000,ko00001,ko00537,ko01000 GH37,GH65 Bacteria 23F8Z@1762,2GKEV@201174,COG0637@1,COG0637@2,COG1554@1,COG1554@2,COG1877@1,COG1877@2 NA|NA|NA G hydrolase, family 65, central catalytic OLIIENHM_01909 931627.MycrhDRAFT_4519 6.7e-119 433.7 Mycobacteriaceae Bacteria 2343K@1762,2GMFE@201174,COG0589@1,COG0589@2 NA|NA|NA T Universal stress protein OLIIENHM_01910 931627.MycrhDRAFT_4518 2.5e-215 755.0 Mycobacteriaceae devS 2.7.13.3 ko:K07682,ko:K20487 ko02020,ko02024,map02020,map02024 M00482,M00816 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 23337@1762,2GIWI@201174,COG3850@1,COG3850@2 NA|NA|NA T Histidine kinase OLIIENHM_01911 1440774.Y900_021125 1.1e-102 379.4 Mycobacteriaceae devR GO:0001666,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005576,GO:0005615,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006950,GO:0008150,GO:0009405,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010565,GO:0010604,GO:0010628,GO:0016020,GO:0018995,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0022611,GO:0030312,GO:0030430,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032502,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0033655,GO:0036293,GO:0043656,GO:0043657,GO:0044174,GO:0044215,GO:0044216,GO:0044217,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0070482,GO:0071944,GO:0072493,GO:0080090,GO:0080134,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1902882,GO:1903506,GO:1903508,GO:2000112,GO:2001141 ko:K02479,ko:K07695 ko02020,map02020 M00482 ko00000,ko00001,ko00002,ko02022 Bacteria 232FX@1762,2GK4B@201174,COG2197@1,COG2197@2 NA|NA|NA K Regulator OLIIENHM_01912 931627.MycrhDRAFT_4516 6.5e-79 300.8 Mycobacteriaceae GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 Bacteria 235YW@1762,2I918@201174,COG0589@1,COG0589@2 NA|NA|NA T Belongs to the universal stress protein A family OLIIENHM_01913 931627.MycrhDRAFT_4515 1.2e-132 479.6 Mycobacteriaceae pfkB GO:0000287,GO:0003674,GO:0003824,GO:0003872,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008443,GO:0009024,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019200,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046835,GO:0046872,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0055086,GO:0061615,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.1.11,2.7.1.56 ko:K00882,ko:K16370 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00345 R00756,R02071,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 iAPECO1_1312.APECO1_793,iUTI89_1310.UTI89_C1916 Bacteria 2376H@1762,2GK7E@201174,COG1105@1,COG1105@2 NA|NA|NA H belongs to the carbohydrate kinase PfkB family OLIIENHM_01914 931627.MycrhDRAFT_4514 0.0 1172.1 Mycobacteriaceae GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 ko:K07100 ko00000 Bacteria 236TQ@1762,2GJUU@201174,COG1926@1,COG1926@2,COG2312@1,COG2312@2 NA|NA|NA S phosphoribosyl transferase OLIIENHM_01915 931627.MycrhDRAFT_4512 1.6e-90 339.0 Mycobacteriaceae Bacteria 237CR@1762,2IBWM@201174,COG3832@1,COG3832@2 NA|NA|NA J glyoxalase III activity OLIIENHM_01917 931627.MycrhDRAFT_4510 1.2e-173 616.3 Mycobacteriaceae gntK GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0009987,GO:0030312,GO:0044464,GO:0044764,GO:0046812,GO:0051704,GO:0071944 2.3.1.82,2.7.1.12 ko:K00663,ko:K00851,ko:K07028 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 R01737 RC00002,RC00017 ko00000,ko00001,ko01000,ko01504 Bacteria 23637@1762,2GM3U@201174,COG0645@1,COG0645@2,COG2187@1,COG2187@2 NA|NA|NA S AAA domain OLIIENHM_01918 931627.MycrhDRAFT_4509 0.0 1192.9 Mycobacteriaceae ppsA 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 Bacteria 2337W@1762,2GMN4@201174,COG0574@1,COG0574@2,COG1080@1,COG1080@2 NA|NA|NA H Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate OLIIENHM_01919 931627.MycrhDRAFT_4504 4.9e-107 394.0 Mycobacteriaceae Bacteria 23463@1762,2HUW8@201174,COG3757@1,COG3757@2 NA|NA|NA M Domain of unknown function (DUF1906) OLIIENHM_01921 1150599.MPHLEI_03378 3.4e-60 237.7 Mycobacteriaceae sucC GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 Bacteria 235AR@1762,2GKSB@201174,COG0045@1,COG0045@2 NA|NA|NA F Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit OLIIENHM_01922 1150599.MPHLEI_03373 1.5e-150 538.9 Mycobacteriaceae sucD GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 Bacteria 2333B@1762,2GK00@201174,COG0074@1,COG0074@2 NA|NA|NA C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit OLIIENHM_01923 525368.HMPREF0591_4771 1.5e-214 752.3 Mycobacteriaceae 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 232YG@1762,2I3PP@201174,COG0183@1,COG0183@2 NA|NA|NA I Acetyl-CoA acetyltransferase OLIIENHM_01924 547163.BN979_04952 1.3e-148 532.3 Mycobacteriaceae rutA_3 Bacteria 2355P@1762,2GMMJ@201174,COG2141@1,COG2141@2 NA|NA|NA C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases OLIIENHM_01925 931627.MycrhDRAFT_0625 2e-53 216.1 Mycobacteriaceae GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 Bacteria 237XP@1762,2EGIB@1,2GJVM@201174,33AAF@2 NA|NA|NA S Family of unknown function (DUF5336) OLIIENHM_01926 931627.MycrhDRAFT_0626 2e-139 502.7 Mycobacteriaceae GO:0008150,GO:0040007 Bacteria 234CB@1762,2EKVE@1,2HI2V@201174,33EIZ@2 NA|NA|NA OLIIENHM_01927 710685.MycrhN_5938 8.3e-38 162.5 Mycobacteriaceae Bacteria 23AN7@1762,2DJKR@1,2IQH2@201174,32UDA@2 NA|NA|NA OLIIENHM_01928 1408452.JAGZ01000004_gene1798 4.8e-93 347.4 Mycobacteriaceae purN GO:0000287,GO:0003674,GO:0005488,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019752,GO:0034641,GO:0042558,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0046483,GO:0046653,GO:0046872,GO:0051186,GO:0071704,GO:1901360,GO:1901564 2.1.2.2,2.1.2.3,3.5.4.10 ko:K00602,ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04325,R04326,R04560 RC00026,RC00197,RC00263,RC00456,RC01128 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 235YC@1762,2H8QB@201174,COG0299@1,COG0299@2 NA|NA|NA F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate OLIIENHM_01929 931627.MycrhDRAFT_0629 2.9e-261 907.5 Mycobacteriaceae purH GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 iHN637.CLJU_RS04230,iJN678.purH Bacteria 232Y0@1762,2GJWU@201174,COG0138@1,COG0138@2 NA|NA|NA F bifunctional purine biosynthesis protein PurH OLIIENHM_01930 931627.MycrhDRAFT_0630 5.1e-230 803.5 Mycobacteriaceae chlI 6.6.1.1 ko:K03405 ko00860,ko01100,ko01110,map00860,map01100,map01110 R03877 RC01012 ko00000,ko00001,ko01000 iNJ661.Rv0958 Bacteria 2342M@1762,2GMRS@201174,COG1239@1,COG1239@2 NA|NA|NA H magnesium chelatase OLIIENHM_01931 1440774.Y900_008300 0.0 1152.1 Mycobacteriaceae GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K07114 ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 Bacteria 236BE@1762,2H14W@201174,COG4867@1,COG4867@2 NA|NA|NA S von Willebrand factor, type A OLIIENHM_01932 931627.MycrhDRAFT_0632 2.7e-07 63.5 Mycobacteriaceae Bacteria 23BWH@1762,2ASQW@1,2GY3G@201174,31WYF@2 NA|NA|NA OLIIENHM_01933 931627.MycrhDRAFT_0633 4.8e-73 280.8 Mycobacteriaceae GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 232FC@1762,2I8FE@201174,COG4758@1,COG4758@2 NA|NA|NA S Domain of unknown function (DUF1707) OLIIENHM_01934 1265310.CCBD010000082_gene4968 1.4e-96 359.4 Mycobacteriaceae echA7 4.2.1.17,4.2.1.18 ko:K01692,ko:K13766 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00036,M00087 R02085,R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115,RC02416 ko00000,ko00001,ko00002,ko01000 Bacteria 2353I@1762,2GJ0N@201174,COG1024@1,COG1024@2 NA|NA|NA I Enoyl-CoA hydratase OLIIENHM_01935 1380386.JIAW01000028_gene6978 8.5e-186 656.4 Mycobacteriaceae fadE12 GO:0003674,GO:0003824,GO:0003995,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016627,GO:0044464,GO:0055114,GO:0071944 1.3.8.7 ko:K00249,ko:K00257 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04547,R04592,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246,RC01942 ko00000,ko00001,ko00002,ko01000 Bacteria 232NI@1762,2GNFB@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_01936 931627.MycrhDRAFT_0636 8.6e-210 736.9 Mycobacteriaceae accA2 6.4.1.1,6.4.1.3,6.4.1.4 ko:K01959,ko:K01965,ko:K01968 ko00020,ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01120,ko01130,ko01200,ko01230,map00020,map00280,map00620,map00630,map00640,map00720,map01100,map01120,map01130,map01200,map01230 M00036,M00173,M00373,M00620,M00741 R00344,R01859,R04138 RC00040,RC00097,RC00367,RC00609,RC00942 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv0973c Bacteria 23453@1762,2GIZP@201174,COG4770@1,COG4770@2 NA|NA|NA I carboxylase OLIIENHM_01939 1469613.JT55_08235 5.1e-46 190.3 Rhodovulum Bacteria 1RHM3@1224,2AFS6@1,2U9EY@28211,315U5@2,3FE57@34008 NA|NA|NA OLIIENHM_01940 1120797.KB908267_gene3278 2.3e-126 458.8 Mycobacteriaceae Bacteria 235WF@1762,2HN5V@201174,COG2242@1,COG2242@2 NA|NA|NA H Methyltransferase type 12 OLIIENHM_01941 1440774.Y900_023060 1.5e-70 272.7 Bacteria Bacteria COG2813@1,COG2813@2 NA|NA|NA J rRNA (guanine-N2-)-methyltransferase activity OLIIENHM_01942 1440774.Y900_023050 9.8e-160 569.7 Mycobacteriaceae rnhA GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006401,GO:0006725,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016891,GO:0016893,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0032296,GO:0033013,GO:0033014,GO:0034641,GO:0034655,GO:0042364,GO:0042578,GO:0043170,GO:0043755,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046700,GO:0051186,GO:0051188,GO:0071667,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576 3.1.26.4,3.1.3.3,3.1.3.73,3.1.3.85,5.4.2.12 ko:K02226,ko:K03469,ko:K06864,ko:K15634,ko:K22305,ko:K22306,ko:K22316 ko00010,ko00260,ko00680,ko00860,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03030,map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01130,map01200,map01230,map03030 M00001,M00002,M00003,M00122 R00582,R01518,R04594,R11173 RC00017,RC00536 ko00000,ko00001,ko00002,ko01000,ko03032 Bacteria 234GG@1762,2GJ9R@201174,COG0328@1,COG0328@2,COG0406@1,COG0406@2 NA|NA|NA GL Ribonuclease OLIIENHM_01943 1440774.Y900_023045 9.3e-77 293.5 Mycobacteriaceae GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 ko:K07164 ko00000 Bacteria 2346B@1762,2GP84@201174,COG1579@1,COG1579@2 NA|NA|NA S Zn-ribbon protein, possibly nucleic acid-binding OLIIENHM_01944 1440774.Y900_023040 2.2e-162 578.6 Mycobacteriaceae yqfO GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.5.4.16 ko:K22391 ko00790,ko01100,map00790,map01100 M00126 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 Bacteria 233QH@1762,2GKHZ@201174,COG0327@1,COG0327@2 NA|NA|NA S Belongs to the GTP cyclohydrolase I type 2 NIF3 family OLIIENHM_01945 1449048.JQKU01000027_gene5380 2.3e-134 485.3 Mycobacteriaceae cobB GO:0008150,GO:0040007 2.6.1.9,4.1.1.81,6.3.5.11,6.3.5.9 ko:K00817,ko:K02224,ko:K04720 ko00340,ko00350,ko00360,ko00400,ko00401,ko00860,ko00960,ko01100,ko01110,ko01120,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00860,map00960,map01100,map01110,map01120,map01130,map01230 M00026 R00694,R00734,R03243,R05224,R05815,R06530 RC00006,RC00010,RC00517,RC00888,RC01301 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 234PG@1762,2I2ND@201174,COG0079@1,COG0079@2 NA|NA|NA E Aminotransferase OLIIENHM_01946 246196.MSMEI_4207 1e-84 319.7 Mycobacteriaceae pgp GO:0003674,GO:0003824,GO:0004672,GO:0004713,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018108,GO:0018193,GO:0018212,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046777,GO:0071704,GO:0140096,GO:1901564 3.1.3.18 ko:K01091,ko:K07025 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 R01334 RC00017 ko00000,ko00001,ko01000 Bacteria 2335N@1762,2HFGX@201174,COG0546@1,COG0546@2 NA|NA|NA S IA, variant 1 OLIIENHM_01947 547163.BN979_06143 1.5e-67 262.3 Mycobacteriaceae ptpA 3.1.3.48 ko:K01104 ko00000,ko01000 Bacteria 238P9@1762,2IM0Q@201174,COG0394@1,COG0394@2 NA|NA|NA T Low molecular weight phosphotyrosine protein phosphatase OLIIENHM_01948 1440774.Y900_023025 2.1e-106 392.1 Mycobacteriaceae surf1 GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944 ko:K14998 ko00000,ko03029 3.D.4.8 Bacteria 235F0@1762,2GR90@201174,COG3346@1,COG3346@2 NA|NA|NA S SURF1-like protein OLIIENHM_01949 1440774.Y900_023020 3.1e-116 424.9 Mycobacteriaceae cobD GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 6.3.1.10 ko:K02227 ko00860,ko01100,map00860,map01100 M00122 R06529,R07302 RC00090,RC00096 ko00000,ko00001,ko00002,ko01000 Bacteria 234BF@1762,2GMB8@201174,COG1270@1,COG1270@2 NA|NA|NA H Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group OLIIENHM_01951 66429.JOFL01000006_gene1809 5.7e-12 82.0 Actinobacteria Bacteria 2GK45@201174,COG3391@1,COG3391@2 NA|NA|NA M 40-residue YVTN family beta-propeller repeat OLIIENHM_01952 1194972.MVAC_23856 2.5e-130 471.5 Mycobacteriaceae pdxS GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0040007,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 4.3.3.6 ko:K06215 ko00750,map00750 R07456 RC00010,RC01783,RC03043 ko00000,ko00001,ko01000 Bacteria 234FS@1762,2GK1T@201174,COG0214@1,COG0214@2 NA|NA|NA H Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively OLIIENHM_01953 1380386.JIAW01000004_gene41 9.5e-123 446.4 Mycobacteriaceae tesB ko:K10805 ko01040,map01040 ko00000,ko00001,ko01000,ko01004 iNJ661.Rv2605c Bacteria 235P8@1762,2GJ1B@201174,COG1946@1,COG1946@2 NA|NA|NA I Acyl-CoA thioesterase OLIIENHM_01954 1440774.Y900_001810 3.3e-85 321.2 Mycobacteriaceae pdxT GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0071496,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600 4.3.3.6 ko:K08681 ko00750,map00750 R07456 RC00010,RC01783,RC03043 ko00000,ko00001,ko01000 iHN637.CLJU_RS19495 Bacteria 232VX@1762,2GNYG@201174,COG0311@1,COG0311@2 NA|NA|NA H Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS OLIIENHM_01955 931627.MycrhDRAFT_4329 7.2e-71 273.9 Mycobacteriaceae proA GO:0003674,GO:0003824,GO:0004350,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016620,GO:0016903,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 iLJ478.TM0293,iNJ661.Rv2427c,iYO844.BSU13130 Bacteria 232ZC@1762,2GISA@201174,COG0014@1,COG0014@2 NA|NA|NA E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate OLIIENHM_01956 1440774.Y900_022115 1.1e-90 340.1 Mycobacteriaceae rbsK 2.7.1.15 ko:K00852 ko00030,map00030 R01051,R02750 RC00002,RC00017 ko00000,ko00001,ko01000 Bacteria 232HD@1762,2I04R@201174,COG0524@1,COG0524@2 NA|NA|NA H Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway OLIIENHM_01957 931627.MycrhDRAFT_2170 7.7e-143 513.5 Mycobacteriaceae fbpB 2.3.1.122,2.3.1.20 ko:K18851 ko00561,ko01100,map00561,map01100 M00089 R02251 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 Bacteria 232KQ@1762,2GJX4@201174,COG0627@1,COG0627@2 NA|NA|NA S fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan, and through the synthesis of alpha,alpha-trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) to another TMM, leading to the formation of TDM OLIIENHM_01958 931627.MycrhDRAFT_4333 0.0 1180.6 Mycobacteriaceae nadE GO:0003674,GO:0003824,GO:0003952,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016880,GO:0016884,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.5.1 ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 Bacteria 233EB@1762,2H2H9@201174,COG0171@1,COG0171@2,COG0388@1,COG0388@2 NA|NA|NA H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source OLIIENHM_01959 931627.MycrhDRAFT_4334 1.8e-66 258.8 Mycobacteriaceae yaaI GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006208,GO:0006212,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0017144,GO:0019860,GO:0034641,GO:0042737,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 Bacteria 238N4@1762,2I8U4@201174,COG1335@1,COG1335@2 NA|NA|NA Q isochorismatase OLIIENHM_01960 1440774.Y900_022095 5.8e-128 463.8 Mycobacteriaceae cobB ko:K12410 ko00000,ko01000 Bacteria 233T7@1762,2GJI3@201174,COG0846@1,COG0846@2 NA|NA|NA K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form OLIIENHM_01961 710685.MycrhN_4217 1.5e-44 186.4 Mycobacteriaceae Bacteria 239N4@1762,2EMVN@1,2IBIK@201174,33FHW@2 NA|NA|NA OLIIENHM_01962 931627.MycrhDRAFT_4339 3.4e-168 597.8 Mycobacteriaceae proB GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 Bacteria 232Y1@1762,2GM8U@201174,COG0263@1,COG0263@2 NA|NA|NA E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate OLIIENHM_01963 1440774.Y900_022085 2.6e-245 854.4 Mycobacteriaceae obg GO:0000287,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0032991,GO:0036211,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046777,GO:0046872,GO:0071704,GO:0071944,GO:1901564,GO:1990904 ko:K03979 ko00000,ko01000,ko03009 Bacteria 232JP@1762,2GISB@201174,COG0536@1,COG0536@2 NA|NA|NA S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control OLIIENHM_01964 1440774.Y900_022080 6e-39 166.4 Mycobacteriaceae rpmA GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904 ko:K02899 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 23AQ6@1762,2IQDI@201174,COG0211@1,COG0211@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL27 family OLIIENHM_01965 1048339.KB913029_gene4852 1.3e-32 145.6 Frankiales rplU GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02888 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IQ9A@201174,4ET3X@85013,COG0261@1,COG0261@2 NA|NA|NA J This protein binds to 23S rRNA in the presence of protein L20 OLIIENHM_01966 1120933.ATUY01000009_gene1371 8.9e-27 127.1 Actinobacteria rne GO:0006139,GO:0006364,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 3.1.26.12 ko:K08300,ko:K08301 ko03018,map03018 M00394 ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 Bacteria 2GMM5@201174,4D3JY@85005,COG1530@1,COG1530@2 NA|NA|NA J S1 RNA binding domain protein OLIIENHM_01968 1196835.A458_06205 1.3e-48 198.7 Pseudomonas stutzeri group Bacteria 1NAWV@1224,1S86J@1236,1Z468@136846,2E3RU@1,32YPG@2 NA|NA|NA OLIIENHM_01970 1120797.KB908262_gene3067 1.5e-24 120.6 Mycobacteriaceae Bacteria 23FAB@1762,2I5G7@201174,COG0699@1,COG0699@2 NA|NA|NA S ATPase. Has a role at an early stage in the morphogenesis of the spore coat OLIIENHM_01971 931627.MycrhDRAFT_2574 1.2e-87 329.7 Mycobacteriaceae trmB GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0040007,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.297,2.1.1.33,2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02493,ko:K02527,ko:K03439 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763,R10806 RC00003,RC00009,RC00077,RC00247,RC03279 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005,ko03012,ko03016 GT30 Bacteria 234QK@1762,2GJ8R@201174,COG0220@1,COG0220@2 NA|NA|NA J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA OLIIENHM_01972 931627.MycrhDRAFT_2573 6.3e-104 383.6 Mycobacteriaceae ko:K06860 ko00000 Bacteria 234E5@1762,2GMV5@201174,COG1432@1,COG1432@2 NA|NA|NA S NYN domain OLIIENHM_01973 710686.Mycsm_00138 0.0 1256.9 Mycobacteriaceae mmpL3 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006869,GO:0008150,GO:0009273,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0040007,GO:0042546,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071554,GO:0071702,GO:0071766,GO:0071840,GO:0071944,GO:1901264 ko:K06994,ko:K20470 ko00000,ko02000 2.A.6.5.6 Bacteria 232RG@1762,2GJ5A@201174,COG2409@1,COG2409@2 NA|NA|NA S lipid transport OLIIENHM_01974 1440774.Y900_014585 2e-150 538.9 Mycobacteriaceae GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 ko:K20469 ko00000,ko02000 2.A.86.1.7 Bacteria 232X7@1762,2GK0H@201174,COG0628@1,COG0628@2 NA|NA|NA S AI-2E family transporter OLIIENHM_01975 931627.MycrhDRAFT_2570 5.8e-166 590.5 Mycobacteriaceae ko:K07027,ko:K20468 ko00000,ko02000 4.D.2,4.D.2.4.1 Bacteria 232A8@1762,2HMHF@201174,COG0392@1,COG0392@2 NA|NA|NA S integral membrane protein OLIIENHM_01976 1341646.CBMO010000019_gene6201 2.1e-40 171.8 Mycobacteriaceae Bacteria 23A0E@1762,2E6D0@1,2GQP8@201174,3310N@2 NA|NA|NA S Protein of unknown function (DUF3054) OLIIENHM_01977 1440774.Y900_014555 2.4e-38 164.9 Mycobacteriaceae Bacteria 239D4@1762,2APGR@1,2IHY8@201174,31EJJ@2 NA|NA|NA S Haemophore, haem-binding OLIIENHM_01978 931627.MycrhDRAFT_2564 0.0 1399.8 Mycobacteriaceae mmpL11 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 ko:K06994,ko:K20466 ko00000,ko02000 2.A.6.5.5 Bacteria 232WK@1762,2GJ5A@201174,COG2409@1,COG2409@2 NA|NA|NA S biological_process OLIIENHM_01979 1440774.Y900_014540 3.6e-56 224.6 Mycobacteriaceae Bacteria 238RR@1762,2E42V@1,2IG4T@201174,32YZ9@2 NA|NA|NA OLIIENHM_01980 1440774.Y900_014535 7.9e-49 199.9 Mycobacteriaceae yccU GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.5.1.49 ko:K01740,ko:K06929 ko00270,ko01100,map00270,map01100 R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 Bacteria 23964@1762,2IHSP@201174,COG1832@1,COG1832@2 NA|NA|NA S CoA-binding OLIIENHM_01981 931627.MycrhDRAFT_2561 2.3e-74 285.4 Mycobacteriaceae Bacteria 233XM@1762,2A2U6@1,2GP6X@201174,30R82@2 NA|NA|NA OLIIENHM_01982 931627.MycrhDRAFT_2560 4.9e-57 227.6 Mycobacteriaceae Bacteria 236HW@1762,2BKG3@1,2ICG8@201174,32EWX@2 NA|NA|NA OLIIENHM_01983 931627.MycrhDRAFT_2559 0.0 1090.9 Mycobacteriaceae pepO 3.4.24.11,3.4.24.71 ko:K01389,ko:K01415,ko:K07386 ko04614,ko04640,ko04974,ko05010,map04614,map04640,map04974,map05010 ko00000,ko00001,ko01000,ko01002,ko04090,ko04147 Bacteria 2331P@1762,2GNJY@201174,COG3590@1,COG3590@2 NA|NA|NA O peptidase OLIIENHM_01984 931627.MycrhDRAFT_2555 2.8e-130 471.9 Mycobacteriaceae lppS Bacteria 234BN@1762,2I22H@201174,COG1376@1,COG1376@2 NA|NA|NA S ErfK YbiS YcfS YnhG family protein OLIIENHM_01985 931627.MycrhDRAFT_2554 1.7e-147 529.3 Mycobacteriaceae Bacteria 2334R@1762,2H012@201174,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily OLIIENHM_01986 931627.MycrhDRAFT_2553 2.2e-38 164.9 Mycobacteriaceae csoR GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010038,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0042221,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0046688,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 ko:K21600 ko00000,ko03000 Bacteria 23A0Q@1762,2IQAC@201174,COG1937@1,COG1937@2 NA|NA|NA S Metal-sensitive transcriptional repressor OLIIENHM_01987 931627.MycrhDRAFT_2552 1.1e-48 199.9 Mycobacteriaceae Bacteria 238SU@1762,2IKUE@201174,COG3544@1,COG3544@2 NA|NA|NA S Domain of unknown function (DUF4142) OLIIENHM_01988 1440774.Y900_014480 2.1e-294 1017.7 Mycobacteriaceae ilvD GO:0003674,GO:0003824,GO:0004160,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 Bacteria 233VR@1762,2GJIJ@201174,COG0129@1,COG0129@2 NA|NA|NA E Belongs to the ILVD EDD family OLIIENHM_01989 1298864.AUEQ01000018_gene3999 8.9e-25 119.8 Mycobacteriaceae Bacteria 23A2V@1762,2IRP5@201174,COG4226@1,COG4226@2 NA|NA|NA S HicB family OLIIENHM_01990 931627.MycrhDRAFT_2550 6.5e-57 228.8 Mycobacteriaceae Bacteria 234XE@1762,2GKHF@201174,COG5651@1,COG5651@2 NA|NA|NA N PPE family OLIIENHM_01991 1440774.Y900_014455 0.0 1176.0 Mycobacteriaceae Bacteria 233RN@1762,2GNYQ@201174,COG0243@1,COG0243@2 NA|NA|NA C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family OLIIENHM_01992 1078020.KEK_05207 7.1e-68 263.8 Mycobacteriaceae 2.1.1.104 ko:K00588 ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110 M00039,M00350 R01942,R06578 RC00003,RC00392 ko00000,ko00001,ko00002,ko01000 Bacteria 234P5@1762,2GP7A@201174,COG4122@1,COG4122@2 NA|NA|NA S O-methyltransferase OLIIENHM_01993 1440774.Y900_014445 1.2e-61 242.7 Mycobacteriaceae Bacteria 238SR@1762,2DPFG@1,2IG6V@201174,331UX@2 NA|NA|NA OLIIENHM_01994 931627.MycrhDRAFT_2544 1.9e-101 375.6 Mycobacteriaceae Bacteria 234HU@1762,2AUNZ@1,2GP4I@201174,31KBW@2 NA|NA|NA S Protein of unknown function (DUF2786) OLIIENHM_01995 931627.MycrhDRAFT_2543 2.3e-134 485.3 Mycobacteriaceae ko:K06889 ko00000 Bacteria 233SR@1762,2GKYQ@201174,COG1073@1,COG1073@2 NA|NA|NA S COG1073 Hydrolases of the alpha beta superfamily OLIIENHM_01996 931627.MycrhDRAFT_2542 6e-117 427.2 Mycobacteriaceae ytpA GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0010941,GO:0010942,GO:0016020,GO:0016042,GO:0016298,GO:0016787,GO:0016788,GO:0030312,GO:0031341,GO:0031343,GO:0031640,GO:0035821,GO:0042981,GO:0043065,GO:0043067,GO:0043068,GO:0043900,GO:0043902,GO:0043903,GO:0044003,GO:0044004,GO:0044068,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044364,GO:0044403,GO:0044419,GO:0044464,GO:0044531,GO:0044532,GO:0044533,GO:0046486,GO:0046503,GO:0047372,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051701,GO:0051704,GO:0051709,GO:0051712,GO:0051817,GO:0051818,GO:0051883,GO:0052040,GO:0052042,GO:0052150,GO:0052151,GO:0052248,GO:0052330,GO:0052433,GO:0052501,GO:0052689,GO:0065007,GO:0071704,GO:0071944,GO:1901575 3.1.1.5 ko:K01048 ko00564,map00564 ko00000,ko00001,ko01000 Bacteria 232BV@1762,2GPA8@201174,COG2267@1,COG2267@2 NA|NA|NA I hydrolase OLIIENHM_01997 1440774.Y900_014385 1.7e-28 131.7 Mycobacteriaceae Bacteria 23AJC@1762,2IQGD@201174,COG2261@1,COG2261@2 NA|NA|NA S transglycosylase OLIIENHM_01998 931627.MycrhDRAFT_2534 1.1e-155 556.2 Mycobacteriaceae lprO Bacteria 233B5@1762,2F81I@1,2I90N@201174,340F0@2 NA|NA|NA S Phosphodiester glycosidase OLIIENHM_01999 931627.MycrhDRAFT_2531 6.5e-56 224.2 Mycobacteriaceae ko:K18481 M00670 ko00000,ko00002,ko02000 3.A.1.27.4,3.A.1.27.5 Bacteria 232I0@1762,2BKHN@1,2ICGR@201174,32EYT@2 NA|NA|NA OLIIENHM_02000 1440774.Y900_014365 3.1e-53 214.9 Mycobacteriaceae ko:K18481 M00670 ko00000,ko00002,ko02000 3.A.1.27.4,3.A.1.27.5 Bacteria 2332J@1762,2AKBR@1,2GM4N@201174,31B2M@2 NA|NA|NA OLIIENHM_02001 1440774.Y900_014360 1e-90 340.5 Mycobacteriaceae 2.7.11.1 ko:K12132,ko:K18481 M00670 ko00000,ko00002,ko01000,ko01001,ko02000 3.A.1.27.4,3.A.1.27.5 Bacteria 234GF@1762,2GNVJ@201174,COG1714@1,COG1714@2 NA|NA|NA S membrane protein domain OLIIENHM_02002 1440774.Y900_014355 1.2e-48 199.9 Mycobacteriaceae ko:K18481 M00670 ko00000,ko00002,ko02000 3.A.1.27.4,3.A.1.27.5 Bacteria 232XK@1762,2ANQH@1,2IBBH@201174,31DQ3@2 NA|NA|NA OLIIENHM_02003 931627.MycrhDRAFT_2527 2.1e-203 715.3 Mycobacteriaceae mce1F ko:K02067 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 232GJ@1762,2GNEP@201174,COG1463@1,COG1463@2 NA|NA|NA Q Virulence factor Mce family protein OLIIENHM_02004 1440774.Y900_014345 1.4e-156 559.3 Mycobacteriaceae ko:K02067 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 233HJ@1762,2GJVB@201174,COG1463@1,COG1463@2 NA|NA|NA Q Virulence factor Mce family protein OLIIENHM_02005 931627.MycrhDRAFT_2525 6.8e-210 736.9 Mycobacteriaceae ko:K02067 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 234NQ@1762,2GNXN@201174,COG1463@1,COG1463@2 NA|NA|NA Q Virulence factor Mce family protein OLIIENHM_02006 931627.MycrhDRAFT_2524 1.4e-137 496.5 Mycobacteriaceae ko:K02067 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 233E5@1762,2GMU6@201174,COG1463@1,COG1463@2 NA|NA|NA Q Virulence factor Mce family protein OLIIENHM_02007 1440774.Y900_014330 2.3e-142 511.9 Mycobacteriaceae mce1B ko:K02067 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 2356V@1762,2GKHV@201174,COG1463@1,COG1463@2 NA|NA|NA Q Virulence factor Mce family protein OLIIENHM_02008 931627.MycrhDRAFT_2522 1.5e-156 559.3 Mycobacteriaceae mce2A ko:K02067 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 233R8@1762,2GNXB@201174,COG1463@1,COG1463@2 NA|NA|NA Q Virulence factor Mce family protein OLIIENHM_02009 164757.Mjls_0107 7e-113 413.7 Mycobacteriaceae ko:K02066 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 233I4@1762,2GJ27@201174,COG0767@1,COG0767@2 NA|NA|NA Q ABC-type transport system involved in resistance to organic solvents, permease component OLIIENHM_02010 350054.Mflv_0713 1.1e-104 386.3 Mycobacteriaceae ko:K02066 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 2329K@1762,2GXR8@201174,COG0767@1,COG0767@2 NA|NA|NA Q ABC-type transport system involved in resistance to organic solvents, permease component OLIIENHM_02011 47839.CCAU010000002_gene2737 8.5e-237 826.2 Mycobacteriaceae fadD5 6.2.1.3 ko:K00666,ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 Bacteria 232ME@1762,2GIUC@201174,COG0318@1,COG0318@2 NA|NA|NA IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II OLIIENHM_02012 1440774.Y900_014300 1.5e-55 222.2 Mycobacteriaceae Bacteria 238W0@1762,2IFB6@201174,COG2867@1,COG2867@2 NA|NA|NA I Cyclase dehydrase OLIIENHM_02013 1440774.Y900_014295 7.1e-105 386.7 Mycobacteriaceae Bacteria 233S7@1762,2GKE2@201174,COG1309@1,COG1309@2 NA|NA|NA K Transcriptional regulator OLIIENHM_02014 931627.MycrhDRAFT_2514 5.7e-10 68.9 Mycobacteriaceae Bacteria 23BTP@1762,2GWRM@201174,COG2340@1,COG2340@2 NA|NA|NA S Cysteine-rich secretory protein family OLIIENHM_02015 1440774.Y900_014280 1.6e-61 242.3 Mycobacteriaceae ybgC ko:K07107 ko00000,ko01000 Bacteria 23AFC@1762,2IMK1@201174,COG0824@1,COG0824@2 NA|NA|NA S Thioesterase OLIIENHM_02016 1150599.MPHLEI_25776 2e-213 748.4 Mycobacteriaceae pntB 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 R00112 RC00001 ko00000,ko00001,ko01000 Bacteria 236BI@1762,2GNKB@201174,COG1282@1,COG1282@2 NA|NA|NA C the transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane OLIIENHM_02017 1150599.MPHLEI_25771 4.6e-44 183.7 Mycobacteriaceae pntAb 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 R00112 RC00001 ko00000,ko00001,ko01000 Bacteria 239Y2@1762,2IKR9@201174,COG3288@1,COG3288@2 NA|NA|NA C NADP transhydrogenase OLIIENHM_02018 525368.HMPREF0591_3188 2.2e-164 585.1 Mycobacteriaceae pntAA 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 R00112 RC00001 ko00000,ko00001,ko01000 Bacteria 234XC@1762,2I2FZ@201174,COG3288@1,COG3288@2 NA|NA|NA C NAD(P) transhydrogenase, alpha subunit OLIIENHM_02020 931627.MycrhDRAFT_5437 7.4e-104 383.6 Mycobacteriaceae Bacteria 2332V@1762,2GN2J@201174,COG0451@1,COG0451@2 NA|NA|NA M epimerase dehydratase OLIIENHM_02021 931627.MycrhDRAFT_5438 1.4e-115 422.5 Mycobacteriaceae Bacteria 233N6@1762,2GNM4@201174,COG1028@1,COG1028@2 NA|NA|NA IQ Short-chain dehydrogenase reductase sdr OLIIENHM_02022 931627.MycrhDRAFT_5439 4.3e-140 504.6 Mycobacteriaceae ydiK GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 Bacteria 2337A@1762,2HT12@201174,COG0628@1,COG0628@2 NA|NA|NA S AI-2E family transporter OLIIENHM_02023 1370125.AUWT01000006_gene3217 4.5e-114 417.5 Mycobacteriaceae 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 Bacteria 233EC@1762,2GK7H@201174,COG0412@1,COG0412@2 NA|NA|NA Q dienelactone hydrolase OLIIENHM_02024 931627.MycrhDRAFT_5444 1.1e-66 259.6 Mycobacteriaceae Bacteria 2335K@1762,2E5JR@1,2I8NX@201174,330AZ@2 NA|NA|NA S Protein of unknown function (DUF4245) OLIIENHM_02025 246196.MSMEI_5101 1.3e-168 599.0 Mycobacteriaceae glpX GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0030388,GO:0042132,GO:0042578,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0050308,GO:0071704,GO:1901135,GO:1901576 3.1.3.11,3.1.3.37 ko:K02446,ko:K11532 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00165,M00167 R00762,R01845,R04780 RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 233Z7@1762,2GMQU@201174,COG1494@1,COG1494@2 NA|NA|NA G fructose-1,6-bisphosphatase OLIIENHM_02026 931627.MycrhDRAFT_5446 2.2e-233 814.7 Mycobacteriaceae fumC GO:0003674,GO:0003824,GO:0004333,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0071944,GO:0072350 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 Bacteria 2330K@1762,2GKWY@201174,COG0114@1,COG0114@2 NA|NA|NA C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate OLIIENHM_02027 1440774.Y900_018830 1.6e-142 512.7 Mycobacteriaceae Bacteria 23EXK@1762,2I37Q@201174,COG0025@1,COG0025@2 NA|NA|NA P Sodium/hydrogen exchanger family OLIIENHM_02028 875328.JDM601_1044 2.1e-117 428.7 Mycobacteriaceae 3.5.1.104 ko:K22278 ko00000,ko01000 Bacteria 2347B@1762,2HEQK@201174,COG0726@1,COG0726@2 NA|NA|NA G polysaccharide deacetylase OLIIENHM_02029 1370121.AUWS01000006_gene5092 4.7e-233 813.5 Mycobacteriaceae phoH ko:K07175 ko00000 Bacteria 234V9@1762,2GK8U@201174,COG1875@1,COG1875@2 NA|NA|NA T ATPase related to phosphate starvation-inducible protein PhoH OLIIENHM_02030 931627.MycrhDRAFT_3742 3.2e-118 431.4 Mycobacteriaceae desA2 GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0071944 1.14.19.11,1.14.19.2,1.14.19.26 ko:K03921,ko:K03922 ko00061,ko01040,ko01212,map00061,map01040,map01212 R03370,R08161,R11108,R11109 RC00917 ko00000,ko00001,ko01000,ko01004 Bacteria 232UI@1762,2GMRX@201174,COG0208@1,COG0208@2 NA|NA|NA F PFAM Fatty acid desaturase OLIIENHM_02032 931627.MycrhDRAFT_2241 1.7e-60 238.8 Mycobacteriaceae rplI GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02939 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 238KE@1762,2IKX7@201174,COG0359@1,COG0359@2 NA|NA|NA J binds to the 23S rRNA OLIIENHM_02033 710686.Mycsm_06467 2.1e-36 157.9 Mycobacteriaceae rpsR GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02963,ko:K03111,ko:K15125 ko03010,ko03030,ko03430,ko03440,ko05133,map03010,map03030,map03430,map03440,map05133 M00178 br01610,ko00000,ko00001,ko00002,ko00536,ko03011,ko03029,ko03032,ko03400 Bacteria 239YE@1762,2IQ92@201174,COG0238@1,COG0238@2 NA|NA|NA J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit OLIIENHM_02034 350058.Mvan_6033 4.9e-69 267.3 Mycobacteriaceae ssb GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0042221,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071944,GO:0097159,GO:1901363 ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 ko00000,ko00001,ko03029,ko03032,ko03400 Bacteria 232AP@1762,2GMM3@201174,COG0629@1,COG0629@2 NA|NA|NA L Single-stranded DNA-binding protein OLIIENHM_02035 1440774.Y900_013125 4.7e-45 186.8 Mycobacteriaceae rpsF GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0019843,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071944,GO:0097159,GO:1901363,GO:1990904 ko:K02990 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011,ko03029 Bacteria 23A21@1762,2IQHD@201174,COG0360@1,COG0360@2 NA|NA|NA J Binds together with S18 to 16S ribosomal RNA OLIIENHM_02036 931627.MycrhDRAFT_2245 3e-92 344.7 Mycobacteriaceae Bacteria 232C9@1762,2H6FV@201174,COG0693@1,COG0693@2 NA|NA|NA S DJ-1 PfpI family OLIIENHM_02037 1440774.Y900_013135 2.7e-241 841.3 Mycobacteriaceae Bacteria 233JA@1762,2GJYA@201174,COG5650@1,COG5650@2 NA|NA|NA S integral membrane protein OLIIENHM_02038 1150599.MPHLEI_25181 7.1e-296 1023.1 Mycobacteriaceae mrcB GO:0001666,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006950,GO:0008144,GO:0008150,GO:0008658,GO:0009628,GO:0009987,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0033218,GO:0033293,GO:0033554,GO:0036094,GO:0036293,GO:0036294,GO:0042221,GO:0042597,GO:0043167,GO:0043168,GO:0043177,GO:0044464,GO:0050896,GO:0051716,GO:0070482,GO:0070887,GO:0071453,GO:0071456,GO:0097159,GO:1901363,GO:1901681 2.4.1.129,3.4.16.4 ko:K05365,ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 GT51 Bacteria 233EY@1762,2GK21@201174,COG0744@1,COG0744@2 NA|NA|NA M penicillin-binding protein OLIIENHM_02039 525368.HMPREF0591_2923 3.7e-63 247.7 Mycobacteriaceae Bacteria 238NM@1762,2CQNK@1,2IIJ7@201174,32SMG@2 NA|NA|NA S Family of unknown function (DUF5318) OLIIENHM_02040 931627.MycrhDRAFT_2249 1.8e-116 425.6 Mycobacteriaceae GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 Bacteria 23378@1762,2FB62@1,2GM8N@201174,343CC@2 NA|NA|NA S Domain of unknown function (DUF1707) OLIIENHM_02041 1440774.Y900_013155 7.2e-87 326.6 Mycobacteriaceae laaE Bacteria 235Z0@1762,2GMJM@201174,COG1695@1,COG1695@2 NA|NA|NA K Transcriptional regulator OLIIENHM_02043 1396141.BATP01000043_gene1929 8e-54 219.9 Verrucomicrobiae Bacteria 2IVD0@203494,46ZJW@74201,COG5337@1,COG5337@2 NA|NA|NA M CotH kinase protein OLIIENHM_02045 1403819.BATR01000181_gene6070 8.8e-129 466.8 Verrucomicrobiae feoB ko:K04759 ko00000,ko02000 9.A.8.1 Bacteria 2ITUZ@203494,46SH4@74201,COG0370@1,COG0370@2 NA|NA|NA P Ferrous iron transport protein B C terminus OLIIENHM_02046 525368.HMPREF0591_4110 2.2e-188 665.2 Mycobacteriaceae pdtaS GO:0000155,GO:0000160,GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005524,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0017076,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 2.7.13.3 ko:K00936 M00839 ko00000,ko00002,ko01000,ko01001,ko02022 Bacteria 235I0@1762,2GKMP@201174,COG3920@1,COG3920@2 NA|NA|NA T Histidine kinase OLIIENHM_02047 246196.MSMEI_1876 1.5e-13 82.0 Mycobacteriaceae yngHB 2.1.3.1,6.4.1.1 ko:K01958,ko:K02160,ko:K17490 ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko01230,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212,map01230 M00082,M00173,M00376 R00344,R00353,R00742 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 Bacteria 23AN9@1762,2GQHZ@201174,COG1038@1,COG1038@2 NA|NA|NA C Biotin-lipoyl like OLIIENHM_02048 164757.Mjls_1714 1.1e-37 164.5 Mycobacteriaceae Bacteria 237ZD@1762,2IDSD@201174,COG5651@1,COG5651@2 NA|NA|NA N pfam pe-ppe OLIIENHM_02049 1440774.Y900_006235 8.5e-28 129.4 Mycobacteriaceae rsrA GO:0000988,GO:0000989,GO:0003674,GO:0005488,GO:0006950,GO:0006979,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009593,GO:0009628,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032502,GO:0042221,GO:0043167,GO:0043169,GO:0043934,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051606,GO:0051775,GO:0051776,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141 Bacteria 23A1R@1762,2IM2X@201174,COG5662@1,COG5662@2 NA|NA|NA K anti-sigma factor OLIIENHM_02050 700508.D174_08610 8.9e-97 359.8 Mycobacteriaceae sigH GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0043254,GO:0044087,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141 ko:K03088 ko00000,ko03021 Bacteria 232XC@1762,2GJ02@201174,COG1595@1,COG1595@2 NA|NA|NA K Belongs to the sigma-70 factor family. ECF subfamily OLIIENHM_02053 710421.Mycch_1389 2.7e-141 508.1 Mycobacteriaceae Bacteria 23320@1762,2GIRG@201174,COG1028@1,COG1028@2 NA|NA|NA IQ Dehydrogenase OLIIENHM_02054 931627.MycrhDRAFT_1094 1.9e-241 841.6 Mycobacteriaceae 1.2.99.10 ko:K22445 ko00000,ko01000 Bacteria 2338K@1762,2GJ95@201174,COG1012@1,COG1012@2 NA|NA|NA C Belongs to the aldehyde dehydrogenase family OLIIENHM_02055 931627.MycrhDRAFT_1093 1.2e-83 317.0 Mycobacteriaceae yedK Bacteria 233ZW@1762,2GKY8@201174,COG2135@1,COG2135@2 NA|NA|NA S Belongs to the SOS response-associated peptidase family OLIIENHM_02056 931627.MycrhDRAFT_5050 4.1e-285 986.9 Mycobacteriaceae treZ GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009251,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016052,GO:0016787,GO:0016798,GO:0030978,GO:0030980,GO:0033942,GO:0034637,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0071704,GO:1901575,GO:1901576 3.2.1.141 ko:K01236 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11256 RC00049 ko00000,ko00001,ko00002,ko01000 CBM48,GH13 Bacteria 234GA@1762,2GMIS@201174,COG0296@1,COG0296@2 NA|NA|NA G 4-alpha-D-((1- 4)-alpha-D-glucano)trehalose trehalohydrolase OLIIENHM_02057 931627.MycrhDRAFT_5051 7.4e-303 1046.2 Mycobacteriaceae treY GO:0000272,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009251,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0030978,GO:0030980,GO:0034637,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0047470,GO:0071704,GO:1901575,GO:1901576 2.4.1.25,5.4.99.15 ko:K00705,ko:K06044 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01824,R05196,R09995 RC00049 ko00000,ko00001,ko00002,ko01000 GH13,GH77 Bacteria 2353R@1762,2GJTB@201174,COG3280@1,COG3280@2 NA|NA|NA G synthase OLIIENHM_02058 1440774.Y900_000430 0.0 1211.8 Mycobacteriaceae glgX 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 ko00000,ko00001,ko00002,ko01000 CBM48,GH13 Bacteria 232WU@1762,2GJ00@201174,COG1523@1,COG1523@2 NA|NA|NA G Belongs to the glycosyl hydrolase 13 family OLIIENHM_02059 1440774.Y900_000425 0.0 1112.1 Mycobacteriaceae wbpC Bacteria 2348B@1762,2GKI5@201174,COG1835@1,COG1835@2 NA|NA|NA I Acyltransferase family OLIIENHM_02060 557599.MKAN_27770 9.3e-210 736.1 Mycobacteriaceae bioA GO:0003674,GO:0003824,GO:0004015,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.6.1.62 ko:K00833 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03231 RC00006,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 iIT341.HP0976,iUTI89_1310.UTI89_C0772,iZ_1308.Z0993 Bacteria 236I6@1762,2I2DN@201174,COG0161@1,COG0161@2 NA|NA|NA H Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor OLIIENHM_02061 1440774.Y900_000415 3.9e-159 567.8 Mycobacteriaceae bioF GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0030312,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0071944,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.29,2.3.1.47 ko:K00639,ko:K00652 ko00260,ko00780,ko01100,map00260,map00780,map01100 M00123,M00573,M00577 R00371,R03210,R10124 RC00004,RC00039,RC00394,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 iJN678.bioF,iNJ661.Rv1569 Bacteria 234M7@1762,2GISV@201174,COG0156@1,COG0156@2 NA|NA|NA E Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide OLIIENHM_02062 931627.MycrhDRAFT_5056 6.5e-77 293.9 Mycobacteriaceae bioD GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004141,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017076,GO:0017144,GO:0018130,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.47,6.3.3.3 ko:K00652,ko:K01935 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03182,R03210,R10124 RC00004,RC00039,RC00868,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 233TF@1762,2GIZ2@201174,COG0132@1,COG0132@2 NA|NA|NA H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring OLIIENHM_02063 1440774.Y900_000405 2.8e-54 218.4 Mycobacteriaceae Bacteria 238VZ@1762,2IFPP@201174,COG1514@1,COG1514@2 NA|NA|NA J 2'-5' RNA ligase superfamily OLIIENHM_02064 1150599.MPHLEI_01731 1.4e-171 609.0 Mycobacteriaceae bioB GO:0003674,GO:0003824,GO:0004076,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0017144,GO:0018130,GO:0019752,GO:0030312,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0070283,GO:0071704,GO:0071944,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1589,iZ_1308.Z0994 Bacteria 2347D@1762,2GIUE@201174,COG0502@1,COG0502@2 NA|NA|NA H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism OLIIENHM_02065 1440774.Y900_000390 5.3e-28 129.8 Mycobacteriaceae GO:0002682,GO:0002684,GO:0008150,GO:0009605,GO:0009607,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0075136 Bacteria 23AVP@1762,2EH0W@1,2GSW1@201174,33ASY@2 NA|NA|NA OLIIENHM_02066 710685.MycrhN_5233 2.2e-52 212.2 Mycobacteriaceae GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 Bacteria 238JF@1762,2BBTC@1,2IFGT@201174,325BP@2 NA|NA|NA S Protein of unknown function (DUF2567) OLIIENHM_02067 931627.MycrhDRAFT_5063 3.4e-199 701.0 Mycobacteriaceae 3.1.1.3 ko:K01046 ko00561,ko01100,map00561,map01100 M00098 R02250,R02687 RC00020,RC00037,RC00041,RC00094 ko00000,ko00001,ko00002,ko01000 Bacteria 234S7@1762,2GJE5@201174,COG1073@1,COG1073@2 NA|NA|NA S Secretory lipase OLIIENHM_02068 1440774.Y900_000375 1.6e-105 389.0 Mycobacteriaceae 3.6.1.55 ko:K03574 ko00000,ko01000,ko03400 Bacteria 2353S@1762,2GNMT@201174,COG1051@1,COG1051@2 NA|NA|NA F Nudix hydrolase OLIIENHM_02069 1440774.Y900_000370 2.8e-172 611.3 Mycobacteriaceae nadA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0030312,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS12020 Bacteria 234ZJ@1762,2GM59@201174,COG0379@1,COG0379@2 NA|NA|NA H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate OLIIENHM_02070 931627.MycrhDRAFT_5066 8.8e-226 789.6 Mycobacteriaceae nadB GO:0008150,GO:0040007 1.3.5.4,1.4.3.16 ko:K00244,ko:K00278 ko00020,ko00190,ko00250,ko00620,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00250,map00620,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00115,M00150,M00173 R00357,R00481,R02164 RC00006,RC00045,RC02566 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1595 Bacteria 233KE@1762,2I2IJ@201174,COG0029@1,COG0029@2 NA|NA|NA H Catalyzes the oxidation of L-aspartate to iminoaspartate OLIIENHM_02071 1440774.Y900_000360 4.1e-129 467.6 Mycobacteriaceae nadC GO:0003674,GO:0003824,GO:0004514,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016020,GO:0016054,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0030312,GO:0034213,GO:0034641,GO:0034654,GO:0042737,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0072526,GO:0090407,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 Bacteria 2336Y@1762,2I2IP@201174,COG0157@1,COG0157@2 NA|NA|NA H Belongs to the NadC ModD family OLIIENHM_02072 931627.MycrhDRAFT_6614 7.1e-50 203.4 Mycobacteriaceae Bacteria 2396D@1762,2C2H7@1,2II6T@201174,329F9@2 NA|NA|NA S deazaflavin-dependent nitroreductase family protein OLIIENHM_02073 931627.MycrhDRAFT_6615 1.9e-83 315.5 Mycobacteriaceae rhtB ko:K05834 ko00000,ko02000 2.A.76.1.1 Bacteria 2345A@1762,2GMDP@201174,COG1280@1,COG1280@2 NA|NA|NA E Lysine exporter protein LysE YggA OLIIENHM_02074 931627.MycrhDRAFT_6616 2.5e-210 738.0 Mycobacteriaceae hisD GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23,1.1.1.308 ko:K00013,ko:K15509 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1599 Bacteria 2329D@1762,2GKKA@201174,COG0141@1,COG0141@2 NA|NA|NA E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine OLIIENHM_02075 931627.MycrhDRAFT_6617 5.5e-161 573.9 Mycobacteriaceae hisC GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 232JG@1762,2GJ9W@201174,COG0079@1,COG0079@2 NA|NA|NA E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily OLIIENHM_02076 931627.MycrhDRAFT_6618 8.3e-98 363.2 Mycobacteriaceae hisB GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0004424,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042578,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23,2.6.1.9,3.1.3.15,4.2.1.19 ko:K00013,ko:K00817,ko:K01089,ko:K01693 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R01158,R01163,R03012,R03013,R03243,R03457 RC00006,RC00017,RC00099,RC00242,RC00463,RC00888,RC00932 ko00000,ko00001,ko00002,ko01000,ko01007 iECO111_1330.ECO111_2746,iECS88_1305.ECS88_2121,iJN746.PP_0289,iLJ478.TM1039,iSB619.SA_RS14130,iUMNK88_1353.UMNK88_2570 Bacteria 235T5@1762,2GKMD@201174,COG0131@1,COG0131@2 NA|NA|NA E imidazoleglycerol-phosphate dehydratase OLIIENHM_02077 1440774.Y900_000330 2.4e-99 368.2 Mycobacteriaceae hisH GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 Bacteria 235WE@1762,2GIYS@201174,COG0118@1,COG0118@2 NA|NA|NA E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR OLIIENHM_02078 931627.MycrhDRAFT_6620 1.7e-114 418.7 Mycobacteriaceae hisA GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16,5.3.1.24 ko:K01814,ko:K01817 ko00340,ko00400,ko01100,ko01110,ko01130,ko01230,map00340,map00400,map01100,map01110,map01130,map01230 M00023,M00026 R03509,R04640 RC00945 ko00000,ko00001,ko00002,ko01000 Bacteria 2348M@1762,2GJ4V@201174,COG0106@1,COG0106@2 NA|NA|NA E Involved in both the histidine and tryptophan biosynthetic pathways OLIIENHM_02079 931627.MycrhDRAFT_6621 2.8e-111 408.3 Mycobacteriaceae impA GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006020,GO:0006021,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009058,GO:0009987,GO:0016020,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0034637,GO:0042578,GO:0043647,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044282,GO:0044283,GO:0044464,GO:0046164,GO:0046165,GO:0046173,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:0071944,GO:1901575,GO:1901576,GO:1901615,GO:1901616,GO:1901617 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 Bacteria 235HT@1762,2GJUM@201174,COG0483@1,COG0483@2 NA|NA|NA G Inositol monophosphatase OLIIENHM_02080 1440774.Y900_000315 2.5e-125 454.9 Mycobacteriaceae hisF GO:0000107,GO:0003674,GO:0003824,GO:0008150,GO:0016740,GO:0016757,GO:0016763,GO:0040007 4.1.3.27 ko:K01657,ko:K02500 ko00340,ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00340,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023,M00026 R00985,R00986,R04558 RC00010,RC01190,RC01943,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 Bacteria 233I0@1762,2GIRP@201174,COG0107@1,COG0107@2 NA|NA|NA E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit OLIIENHM_02081 1341646.CBMO010000087_gene5508 5.3e-51 206.8 Mycobacteriaceae hisI GO:0008150,GO:0040007 3.5.4.19,3.6.1.31 ko:K01496,ko:K11755 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035,R04037 RC00002,RC01055 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1606 Bacteria 2397F@1762,2IKKU@201174,COG0139@1,COG0139@2 NA|NA|NA E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP OLIIENHM_02082 164757.Mjls_3070 3.8e-68 264.2 Mycobacteriaceae bcpB 1.11.1.15 ko:K03564 ko00000,ko01000 Bacteria 238QQ@1762,2IFB1@201174,COG1225@1,COG1225@2 NA|NA|NA O Peroxiredoxin OLIIENHM_02083 931627.MycrhDRAFT_6629 6.6e-255 886.3 Mycobacteriaceae trpE 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 Bacteria 233GR@1762,2GKJT@201174,COG0147@1,COG0147@2 NA|NA|NA E Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia OLIIENHM_02084 1440774.Y900_000280 1.9e-50 205.7 Mycobacteriaceae Bacteria 2363P@1762,2EGC7@1,2IJD8@201174,33A40@2 NA|NA|NA S Trp region conserved OLIIENHM_02085 1440774.Y900_000275 2.7e-122 444.9 Mycobacteriaceae trpC GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004425,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046391,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.48 ko:K01609 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508 RC00944 ko00000,ko00001,ko00002,ko01000 Bacteria 232KE@1762,2GIVV@201174,COG0134@1,COG0134@2 NA|NA|NA E Belongs to the TrpC family OLIIENHM_02086 164757.Mjls_3066 6.8e-213 746.5 Mycobacteriaceae trpB GO:0000162,GO:0003674,GO:0003824,GO:0004834,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 Bacteria 232HW@1762,2GM7Z@201174,COG0133@1,COG0133@2 NA|NA|NA E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine OLIIENHM_02087 931627.MycrhDRAFT_6633 1.6e-119 435.6 Mycobacteriaceae trpA GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 Bacteria 232DM@1762,2GN6T@201174,COG0159@1,COG0159@2 NA|NA|NA E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate OLIIENHM_02088 1440774.Y900_000260 8.5e-160 570.5 Mycobacteriaceae lgt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008961,GO:0009058,GO:0009059,GO:0009249,GO:0009898,GO:0009987,GO:0010467,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0040007,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051604,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0140096,GO:1901564,GO:1901566,GO:1901576 2.1.1.199 ko:K03438,ko:K08930,ko:K13292 ko02020,map02020 ko00000,ko00001,ko00194,ko01000,ko03009 Bacteria 2359B@1762,2GKSS@201174,COG0682@1,COG0682@2,COG3064@1,COG3064@2 NA|NA|NA M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins OLIIENHM_02089 350054.Mflv_3595 1.1e-34 152.9 Mycobacteriaceae Bacteria 23ABN@1762,2IQB3@201174,COG2314@1,COG2314@2 NA|NA|NA S membrane OLIIENHM_02090 931627.MycrhDRAFT_6637 5.6e-47 193.7 Mycobacteriaceae Bacteria 239YB@1762,2EGD2@1,2I847@201174,33A4V@2 NA|NA|NA S Protein of unknown function (DUF2752) OLIIENHM_02091 1440774.Y900_023815 2.1e-226 791.6 Mycobacteriaceae pyk GO:0003674,GO:0003824,GO:0004743,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016043,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042802,GO:0042866,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 e_coli_core.b1854,iAF1260.b1854,iB21_1397.B21_01813,iBWG_1329.BWG_1668,iEC042_1314.EC042_2021,iECBD_1354.ECBD_1784,iECB_1328.ECB_01825,iECDH10B_1368.ECDH10B_1995,iECDH1ME8569_1439.ECDH1ME8569_1801,iECD_1391.ECD_01825,iECO103_1326.ECO103_2044,iECO111_1330.ECO111_2362,iECO26_1355.ECO26_2692,iECUMN_1333.ECUMN_2152,iETEC_1333.ETEC_1887,iEcDH1_1363.EcDH1_1786,iEcE24377_1341.EcE24377A_2084,iEcHS_1320.EcHS_A1947,iEcSMS35_1347.EcSMS35_1332,iEcolC_1368.EcolC_1778,iG2583_1286.G2583_2306,iJO1366.b1854,iJR904.b1854,iSBO_1134.SBO_1162,iSSON_1240.SSON_1294,iSbBS512_1146.SbBS512_E2130,iUMNK88_1353.UMNK88_2326,iY75_1357.Y75_RS09740 Bacteria 2329W@1762,2GJY8@201174,COG0469@1,COG0469@2 NA|NA|NA G Belongs to the pyruvate kinase family OLIIENHM_02092 1380386.JIAW01000011_gene3334 7.2e-129 466.8 Mycobacteriaceae tesB1 ko:K10805 ko01040,map01040 ko00000,ko00001,ko01000,ko01004 Bacteria 23591@1762,2GJ1B@201174,COG1946@1,COG1946@2 NA|NA|NA I Acyl-CoA thioesterase OLIIENHM_02093 931627.MycrhDRAFT_6643 8.3e-43 180.3 Mycobacteriaceae Bacteria 239ME@1762,2DPNA@1,2I2PY@201174,332RJ@2 NA|NA|NA OLIIENHM_02094 1440774.Y900_023855 1.2e-68 266.2 Mycobacteriaceae Bacteria 237S5@1762,2H3AT@201174,COG3247@1,COG3247@2 NA|NA|NA S Short repeat of unknown function (DUF308) OLIIENHM_02095 1380386.JIAW01000011_gene3342 3.1e-130 471.5 Mycobacteriaceae pknD ko:K02030 M00236 ko00000,ko00002,ko02000 3.A.1.3 Bacteria 233DT@1762,2GJQW@201174,COG0834@1,COG0834@2 NA|NA|NA ET ABC transporter substrate-binding protein OLIIENHM_02096 164757.Mjls_3049 4.1e-135 487.6 Mycobacteriaceae yecS ko:K02029,ko:K10009 ko02010,map02010 M00234,M00236 ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.10,3.A.1.3.14 Bacteria 23510@1762,2GJJ9@201174,COG0765@1,COG0765@2 NA|NA|NA P ABC transporter OLIIENHM_02097 931627.MycrhDRAFT_6651 2.9e-121 441.4 Mycobacteriaceae atrC 3.6.3.21 ko:K02028 M00236 ko00000,ko00002,ko01000,ko02000 3.A.1.3 Bacteria 235UU@1762,2GIZW@201174,COG1126@1,COG1126@2 NA|NA|NA E ABC transporter, ATP-binding protein OLIIENHM_02098 931627.MycrhDRAFT_6655 7.3e-178 630.2 Mycobacteriaceae cya GO:0000287,GO:0003674,GO:0003824,GO:0004016,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006171,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009975,GO:0009987,GO:0016020,GO:0016829,GO:0016849,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0023052,GO:0030145,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046058,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052652,GO:0055086,GO:0065007,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.6.1.1,4.6.1.2 ko:K01768,ko:K01769 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 Bacteria 232RR@1762,2HSA4@201174,COG2114@1,COG2114@2 NA|NA|NA T Belongs to the adenylyl cyclase class-4 guanylyl cyclase family OLIIENHM_02099 1068978.AMETH_2309 4.2e-38 164.5 Pseudonocardiales Bacteria 2IFZV@201174,4E6C5@85010,COG3832@1,COG3832@2 NA|NA|NA S PFAM Polyketide cyclase dehydrase OLIIENHM_02103 931627.MycrhDRAFT_6670 9.6e-88 329.7 Mycobacteriaceae pdtaR GO:0000160,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016020,GO:0023052,GO:0030312,GO:0035556,GO:0040007,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071944 ko:K22010 M00839 ko00000,ko00002,ko02022 Bacteria 235QN@1762,2GK7T@201174,COG3707@1,COG3707@2 NA|NA|NA T response regulator OLIIENHM_02104 931627.MycrhDRAFT_6671 9e-183 646.4 Mycobacteriaceae braC ko:K01999 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 235DF@1762,2GM00@201174,COG0683@1,COG0683@2 NA|NA|NA E Amino acid amide ABC transporter substrate-binding protein, HAAT family OLIIENHM_02105 931627.MycrhDRAFT_6671 5.4e-159 567.4 Mycobacteriaceae braC ko:K01999 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 235DF@1762,2GM00@201174,COG0683@1,COG0683@2 NA|NA|NA E Amino acid amide ABC transporter substrate-binding protein, HAAT family OLIIENHM_02106 931627.MycrhDRAFT_6672 7.8e-167 593.2 Mycobacteriaceae livH ko:K01997 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 232H0@1762,2GMAY@201174,COG0559@1,COG0559@2 NA|NA|NA E Belongs to the binding-protein-dependent transport system permease family OLIIENHM_02107 1440774.Y900_023935 1.7e-186 658.7 Mycobacteriaceae livM ko:K01998 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 2347E@1762,2GJB3@201174,COG4177@1,COG4177@2 NA|NA|NA E Belongs to the binding-protein-dependent transport system permease family OLIIENHM_02108 931627.MycrhDRAFT_6674 3.4e-136 491.1 Mycobacteriaceae livG ko:K01995,ko:K01996 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 23515@1762,2GMEE@201174,COG0411@1,COG0411@2 NA|NA|NA E amino acid OLIIENHM_02109 931627.MycrhDRAFT_6675 2.5e-114 418.3 Mycobacteriaceae livF ko:K01995,ko:K01996 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 232CN@1762,2GKSQ@201174,COG0410@1,COG0410@2 NA|NA|NA E amino acid OLIIENHM_02110 931627.MycrhDRAFT_6678 3e-23 114.0 Mycobacteriaceae MA20_25230 ko:K09131 ko00000 Bacteria 23B8W@1762,2GRF6@201174,COG1872@1,COG1872@2 NA|NA|NA S Belongs to the UPF0235 family OLIIENHM_02111 404380.Gbem_0567 6.3e-98 364.4 Deltaproteobacteria glgA GO:0000271,GO:0003674,GO:0003824,GO:0004373,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046527,GO:0055114,GO:0071704,GO:1901576 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 GT5 Bacteria 1MUGM@1224,2WITI@28221,42MT8@68525,COG0297@1,COG0297@2 NA|NA|NA G Synthesizes alpha-1,4-glucan chains using ADP-glucose OLIIENHM_02112 1440774.Y900_018810 3.9e-241 840.5 Mycobacteriaceae glyA 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 Bacteria 233GB@1762,2GK7U@201174,COG0112@1,COG0112@2 NA|NA|NA E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism OLIIENHM_02113 931627.MycrhDRAFT_3740 2.7e-195 688.0 Mycobacteriaceae Bacteria 233W8@1762,2GJQT@201174,COG4805@1,COG4805@2 NA|NA|NA S Protein conserved in bacteria OLIIENHM_02114 931627.MycrhDRAFT_3739 9e-162 576.2 Mycobacteriaceae coaA GO:0003674,GO:0003824,GO:0004594,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.33 ko:K00867 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 2358T@1762,2I4EX@201174,COG0572@1,COG0572@2 NA|NA|NA F Pantothenic acid kinase OLIIENHM_02115 318424.EU78_19610 4e-29 133.7 Mycobacteriaceae atpE GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0015988,GO:0015991,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 iNJ661.Rv1305 Bacteria 23AQH@1762,2IQZQ@201174,COG0636@1,COG0636@2 NA|NA|NA C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation OLIIENHM_02116 931627.MycrhDRAFT_3736 1.6e-19 102.4 Mycobacteriaceae Bacteria 239YF@1762,2CAC8@1,2IKNE@201174,32RR5@2 NA|NA|NA OLIIENHM_02117 931627.MycrhDRAFT_3735 1.8e-174 619.0 Mycobacteriaceae Bacteria 23438@1762,28XJV@1,2I3N6@201174,2ZJGZ@2 NA|NA|NA OLIIENHM_02118 931627.MycrhDRAFT_3734 1e-126 459.5 Mycobacteriaceae uppS1 GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617 2.5.1.31,2.5.1.68 ko:K00806,ko:K12503 ko00900,ko01110,map00900,map01110 R06447,R08528 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 Bacteria 233DA@1762,2GJCP@201174,COG0020@1,COG0020@2 NA|NA|NA H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids OLIIENHM_02119 909613.UO65_5657 1.9e-54 219.2 Actinobacteria Bacteria 28PWR@1,2H37T@201174,2ZCGZ@2 NA|NA|NA OLIIENHM_02121 931627.MycrhDRAFT_2490 1.3e-107 396.0 Mycobacteriaceae aqpZ ko:K02440,ko:K06188 ko00000,ko02000 1.A.8,1.A.8.1,1.A.8.2 Bacteria 234FI@1762,2GKK3@201174,COG0580@1,COG0580@2 NA|NA|NA G Belongs to the MIP aquaporin (TC 1.A.8) family OLIIENHM_02122 931627.MycrhDRAFT_2488 1.1e-129 469.5 Mycobacteriaceae 3.2.2.21 ko:K01247 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 233XS@1762,2GP69@201174,COG0122@1,COG0122@2 NA|NA|NA L DNA glycosylase OLIIENHM_02123 931627.MycrhDRAFT_2486 5.2e-100 370.5 Mycobacteriaceae Bacteria 236JP@1762,2GJQ9@201174,COG0665@1,COG0665@2 NA|NA|NA E FAD dependent oxidoreductase OLIIENHM_02124 1440774.Y900_014890 1.6e-45 188.7 Mycobacteriaceae GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K06889 ko00000 Bacteria 234F7@1762,2I8SP@201174,COG1073@1,COG1073@2 NA|NA|NA S alpha beta OLIIENHM_02125 931627.MycrhDRAFT_2621 1.1e-210 739.2 Mycobacteriaceae fadI GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0003988,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005777,GO:0005782,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0031907,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0032787,GO:0034440,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0055114,GO:0070013,GO:0071704,GO:0072329,GO:0097159,GO:1901363,GO:1901575 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 234WP@1762,2GJI8@201174,COG0183@1,COG0183@2 NA|NA|NA I Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation OLIIENHM_02126 931627.MycrhDRAFT_2620 4.5e-207 727.2 Mycobacteriaceae Bacteria 234SN@1762,2GJCZ@201174,COG1028@1,COG1028@2 NA|NA|NA IQ Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis OLIIENHM_02127 1440774.Y900_014875 5.9e-120 437.2 Mycobacteriaceae Bacteria 2338H@1762,2GNQQ@201174,COG2030@1,COG2030@2 NA|NA|NA I dehydratase OLIIENHM_02128 1440774.Y900_014870 7.4e-88 330.1 Mycobacteriaceae Bacteria 232B4@1762,2GNVS@201174,COG1309@1,COG1309@2 NA|NA|NA K Transcriptional regulator OLIIENHM_02129 1440774.Y900_014865 9.2e-159 566.6 Mycobacteriaceae lpqI 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 Bacteria 234FC@1762,2GM43@201174,COG1472@1,COG1472@2 NA|NA|NA G hydrolase, family 3 OLIIENHM_02130 931627.MycrhDRAFT_2616 1.8e-20 104.4 Mycobacteriaceae Bacteria 23BBD@1762,2A0FU@1,2GR27@201174,30NJN@2 NA|NA|NA S Protein of unknown function (DUF2613) OLIIENHM_02134 350058.Mvan_0761 3.3e-114 418.3 Mycobacteriaceae Bacteria 236SW@1762,2IA1W@201174,COG5651@1,COG5651@2 NA|NA|NA N PE-PPE domain OLIIENHM_02135 710686.Mycsm_00483 2.4e-266 924.5 Mycobacteriaceae sdrA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 23336@1762,2GIU5@201174,COG1061@1,COG1061@2 NA|NA|NA L Type III restriction enzyme, res subunit OLIIENHM_02136 931627.MycrhDRAFT_3070 5.8e-122 443.7 Mycobacteriaceae 3.6.1.1 ko:K01507 ko00190,map00190 ko00000,ko00001,ko01000 Bacteria 23357@1762,2GJG6@201174,COG0647@1,COG0647@2 NA|NA|NA G Hydrolase OLIIENHM_02137 1440774.Y900_016385 6.7e-130 470.3 Mycobacteriaceae Bacteria 233HK@1762,2GIYQ@201174,COG1028@1,COG1028@2 NA|NA|NA IQ Belongs to the short-chain dehydrogenases reductases (SDR) family OLIIENHM_02138 1150599.MPHLEI_05977 2.6e-153 548.5 Mycobacteriaceae moeA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0018315,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0032324,GO:0034641,GO:0036211,GO:0042040,GO:0042278,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0061599,GO:0070566,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 R09735 RC03462 ko00000,ko00001,ko01000 Bacteria 232SK@1762,2GJC3@201174,COG0303@1,COG0303@2 NA|NA|NA H Molybdopterin OLIIENHM_02139 1440774.Y900_016375 3.6e-99 367.9 Mycobacteriaceae psd 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 Bacteria 232X2@1762,2GMMF@201174,COG0688@1,COG0688@2 NA|NA|NA I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) OLIIENHM_02140 258533.BN977_04256 8.9e-108 396.7 Mycobacteriaceae pssA GO:0003674,GO:0003824,GO:0003882,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 Bacteria 2340T@1762,2I3MV@201174,COG1183@1,COG1183@2 NA|NA|NA I Belongs to the CDP-alcohol phosphatidyltransferase class-I family OLIIENHM_02141 931627.MycrhDRAFT_3065 0.0 1169.8 Mycobacteriaceae ko:K13525 ko04141,ko05134,map04141,map05134 M00400,M00403 ko00000,ko00001,ko00002,ko03019,ko04131,ko04147 3.A.16.1 Bacteria 233JY@1762,2GJNW@201174,COG0464@1,COG0464@2,COG1222@1,COG1222@2 NA|NA|NA O Belongs to the AAA ATPase family OLIIENHM_02142 1440774.Y900_016300 7.4e-83 313.5 Mycobacteriaceae lonD 3.4.21.53 ko:K01338,ko:K07157 ko04112,map04112 ko00000,ko00001,ko01000,ko01002 Bacteria 2361E@1762,2GNWA@201174,COG2802@1,COG2802@2 NA|NA|NA S ATP-dependent protease OLIIENHM_02143 931627.MycrhDRAFT_3050 1.6e-22 112.1 Mycobacteriaceae Bacteria 23BHS@1762,2AY6Y@1,2GRUG@201174,31Q90@2 NA|NA|NA OLIIENHM_02144 931627.MycrhDRAFT_3049 8.8e-196 689.5 Mycobacteriaceae ybdK GO:0003674,GO:0003824,GO:0016874,GO:0016879 ko:K06048 ko00000,ko01000 Bacteria 235G7@1762,2GKAA@201174,COG2170@1,COG2170@2 NA|NA|NA H ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity OLIIENHM_02145 1440774.Y900_016285 1.2e-81 309.7 Mycobacteriaceae sodC GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0005575,GO:0005576,GO:0005615,GO:0005618,GO:0005623,GO:0005886,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0010035,GO:0016020,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0019725,GO:0020012,GO:0030312,GO:0030682,GO:0033194,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0042592,GO:0043207,GO:0044237,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044421,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052059,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052385,GO:0052550,GO:0052551,GO:0052564,GO:0052565,GO:0052567,GO:0052572,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071450,GO:0071451,GO:0071944,GO:0072593,GO:0075136,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748 1.15.1.1 ko:K04565 ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020 ko00000,ko00001,ko01000 Bacteria 234MQ@1762,2GMTU@201174,COG2032@1,COG2032@2 NA|NA|NA P Destroys radicals which are normally produced within the cells and which are toxic to biological systems OLIIENHM_02146 931627.MycrhDRAFT_3047 1.9e-45 188.7 Mycobacteriaceae Bacteria 2397D@1762,2DP6P@1,2IIM6@201174,330SA@2 NA|NA|NA S LytR cell envelope-related transcriptional attenuator OLIIENHM_02147 931627.MycrhDRAFT_3046 1.2e-43 182.2 Mycobacteriaceae Bacteria 23A1A@1762,2CUM0@1,2IQG7@201174,32SVJ@2 NA|NA|NA S Protein of unknown function (DUF3263) OLIIENHM_02148 931627.MycrhDRAFT_3045 1.2e-95 355.9 Mycobacteriaceae def GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0035601,GO:0036211,GO:0040007,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0098732,GO:1901564 3.5.1.88 ko:K01462 ko00000,ko01000 Bacteria 235G2@1762,2GJ87@201174,COG0242@1,COG0242@2 NA|NA|NA J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions OLIIENHM_02149 1122247.C731_0608 2.1e-127 461.8 Mycobacteriaceae xthA 3.1.11.2,6.5.1.1 ko:K01142,ko:K01971 ko03410,ko03450,map03410,map03450 R00381 RC00005 ko00000,ko00001,ko01000,ko03400 Bacteria 234X4@1762,2GKEW@201174,COG0708@1,COG0708@2 NA|NA|NA L exodeoxyribonuclease III OLIIENHM_02150 557599.MKAN_17100 4.3e-157 560.8 Mycobacteriaceae yfmJ ko:K07119 ko00000 Bacteria 232K1@1762,2GKR8@201174,COG2130@1,COG2130@2 NA|NA|NA S NADP-dependent oxidoreductase OLIIENHM_02151 931627.MycrhDRAFT_3036 1e-113 416.4 Mycobacteriaceae thiD GO:0008150,GO:0040007 2.5.1.3,2.7.1.35,2.7.1.49,2.7.4.7,4.1.99.17 ko:K00868,ko:K00941,ko:K03147,ko:K21219 ko00730,ko00750,ko01100,map00730,map00750,map01100 M00127 R00174,R01909,R02493,R03223,R03471,R03472,R04509,R10712 RC00002,RC00017,RC00224,RC03251,RC03252,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS03115 Bacteria 2330C@1762,2GKZM@201174,COG0351@1,COG0351@2 NA|NA|NA H Phosphomethylpyrimidine kinase OLIIENHM_02152 1150599.MPHLEI_05857 2.4e-81 308.5 Mycobacteriaceae ko:K07020 ko00000 Bacteria 234V8@1762,2GKKE@201174,COG3571@1,COG3571@2 NA|NA|NA S hydrolase of the alpha beta-hydrolase fold OLIIENHM_02153 710685.MycrhN_1249 1e-239 835.9 Mycobacteriaceae Bacteria 232CF@1762,2GMD5@201174,COG2072@1,COG2072@2 NA|NA|NA P flavoprotein involved in K transport OLIIENHM_02154 1298864.AUEQ01000019_gene3691 2.7e-20 104.4 Mycobacteriaceae Bacteria 23APM@1762,2GQJG@201174,COG4270@1,COG4270@2 NA|NA|NA S Membrane OLIIENHM_02155 1449353.JQMQ01000005_gene3589 7.1e-143 513.8 Streptacidiphilus ko:K03294 ko00000 2.A.3.2 Bacteria 2GJ75@201174,2NHJD@228398,COG0531@1,COG0531@2 NA|NA|NA E Amino acid permease OLIIENHM_02156 1440774.Y900_016185 1.3e-186 659.4 Mycobacteriaceae lpqL GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 235II@1762,2HEN8@201174,COG2234@1,COG2234@2 NA|NA|NA S Peptidase, M28 OLIIENHM_02157 931627.MycrhDRAFT_3022 5e-90 337.4 Mycobacteriaceae thiE GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 iJN678.thiE,iNJ661.Rv0414c Bacteria 233DH@1762,2GKCN@201174,COG0352@1,COG0352@2 NA|NA|NA H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) OLIIENHM_02158 1440774.Y900_016145 5.3e-72 277.3 Mycobacteriaceae mutT3 3.6.1.13,3.6.1.55 ko:K01515,ko:K03574 ko00230,map00230 R01054 RC00002 ko00000,ko00001,ko01000,ko03400 Bacteria 238P2@1762,2II4D@201174,COG0494@1,COG0494@2 NA|NA|NA L Belongs to the NUDIX hydrolase family OLIIENHM_02159 931627.MycrhDRAFT_3020 1.2e-188 666.0 Mycobacteriaceae 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 Bacteria 236RM@1762,2GJ1Q@201174,COG5278@1,COG5278@2 NA|NA|NA T phosphoserine phosphatase activity OLIIENHM_02160 1440774.Y900_016135 1.5e-127 462.6 Mycobacteriaceae glnH ko:K02030 M00236 ko00000,ko00002,ko02000 3.A.1.3 Bacteria 233SS@1762,2GJH8@201174,COG0834@1,COG0834@2 NA|NA|NA ET ABC transporter substrate-binding protein OLIIENHM_02161 1440774.Y900_016130 0.0 1251.9 Mycobacteriaceae Bacteria 232DK@1762,2GJ24@201174,COG0515@1,COG0515@2 NA|NA|NA KLT serine threonine protein kinase OLIIENHM_02162 1440774.Y900_016095 4.4e-163 580.9 Mycobacteriaceae ackA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016053,GO:0016999,GO:0017000,GO:0017144,GO:0019413,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.7.2.1,2.7.2.15 ko:K00925,ko:K19697 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1034,iIT341.HP0903m,iNJ661.Rv0409 Bacteria 232T2@1762,2GJAW@201174,COG0282@1,COG0282@2 NA|NA|NA F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction OLIIENHM_02163 1440774.Y900_016090 0.0 1096.3 Mycobacteriaceae pta GO:0005575,GO:0005576 2.3.1.8 ko:K13788 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00230,R00921 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 Bacteria 234RB@1762,2GJ5U@201174,COG0280@1,COG0280@2,COG0857@1,COG0857@2 NA|NA|NA C belongs to the CobB CobQ family OLIIENHM_02164 164757.Mjls_0522 2.3e-171 608.2 Mycobacteriaceae fgd GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016491,GO:0016614,GO:0019725,GO:0030312,GO:0031406,GO:0036094,GO:0042592,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043177,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0046983,GO:0048037,GO:0050662,GO:0050789,GO:0050794,GO:0055114,GO:0065007,GO:0065008,GO:0070967,GO:0071944,GO:0097159,GO:0097367,GO:1901363 1.1.98.2 ko:K15510 ko00000,ko01000 Bacteria 234JH@1762,2GM94@201174,COG2141@1,COG2141@2 NA|NA|NA C Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone. Appears to have a role in resistance to oxidative stress, via its consumption of G6P that serves as a source of reducing power to combat oxidative stress in mycobacteria OLIIENHM_02165 350058.Mvan_0697 2.6e-92 345.1 Mycobacteriaceae Bacteria 232EN@1762,2H8JM@201174,COG0491@1,COG0491@2 NA|NA|NA S beta-lactamase OLIIENHM_02166 931627.MycrhDRAFT_3007 1.2e-125 456.1 Mycobacteriaceae Bacteria 235ND@1762,2GP17@201174,COG4221@1,COG4221@2 NA|NA|NA S Belongs to the short-chain dehydrogenases reductases (SDR) family OLIIENHM_02168 479431.Namu_1167 1.7e-34 151.4 Frankiales infA GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009986,GO:0016020,GO:0030246,GO:0030247,GO:0030312,GO:0040007,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071944,GO:2001065 ko:K02518 ko00000,ko03012 Bacteria 2IQ4B@201174,4ET4N@85013,COG0361@1,COG0361@2 NA|NA|NA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex OLIIENHM_02169 1299327.I546_0423 3.3e-59 234.2 Mycobacteriaceae rpsM GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02952 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2399I@1762,2IHPN@201174,COG0099@1,COG0099@2 NA|NA|NA J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits OLIIENHM_02170 1150599.MPHLEI_05267 4.8e-67 260.4 Mycobacteriaceae rpsK GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02948 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 238NX@1762,2IFFC@201174,COG0100@1,COG0100@2 NA|NA|NA J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome OLIIENHM_02171 258533.BN977_04644 1.3e-100 372.5 Mycobacteriaceae rpsD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0016020,GO:0019222,GO:0019843,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 ko:K02986 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 23388@1762,2GIRX@201174,COG0522@1,COG0522@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit OLIIENHM_02173 1209984.BN978_06116 1.2e-101 375.9 Mycobacteriaceae uvrA GO:0000018,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045910,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0071944,GO:0080090 ko:K03701 ko03420,map03420 ko00000,ko00001,ko03400 Bacteria 235Z8@1762,2GJUV@201174,COG0178@1,COG0178@2 NA|NA|NA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate OLIIENHM_02174 1078020.KEK_02010 2e-41 175.6 Mycobacteriaceae VY92_09940 ko:K09796 ko00000,ko03110 Bacteria 23A7J@1762,2IR3D@201174,COG2847@1,COG2847@2 NA|NA|NA S Copper chaperone PCu(A)C OLIIENHM_02175 1078020.KEK_02005 3.5e-134 485.0 Mycobacteriaceae 1.11.1.19 ko:K15733 ko00000,ko01000 Bacteria 232Z9@1762,2GIUB@201174,COG2837@1,COG2837@2 NA|NA|NA P Dyp-type peroxidase family OLIIENHM_02176 547163.BN979_06421 4.6e-18 97.4 Mycobacteriaceae rsmP ko:K03969 ko00000 Bacteria 23B6N@1762,2GRMV@201174,COG1842@1,COG1842@2 NA|NA|NA KT COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription OLIIENHM_02177 1440774.Y900_024210 1.9e-166 592.4 Mycobacteriaceae Bacteria 233NB@1762,2GP6Q@201174,COG0627@1,COG0627@2 NA|NA|NA S esterase OLIIENHM_02178 1440774.Y900_024215 0.0 1720.3 Mycobacteriaceae lysS GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006518,GO:0006520,GO:0006629,GO:0006644,GO:0006650,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009059,GO:0009405,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019637,GO:0019752,GO:0030312,GO:0030322,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0042221,GO:0042391,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046471,GO:0046483,GO:0046486,GO:0046677,GO:0046872,GO:0050896,GO:0051704,GO:0065007,GO:0065008,GO:0071704,GO:0071944,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iAF1260.b4129,iECDH1ME8569_1439.ECDH1ME8569_3989,iECW_1372.ECW_m4490,iEcDH1_1363.EcDH1_3862,iJN678.lysS,iJO1366.b4129,iWFL_1372.ECW_m4490 Bacteria 235PM@1762,2GKE0@201174,COG1190@1,COG1190@2,COG2898@1,COG2898@2 NA|NA|NA J Catalyzes the production of L-lysyl-tRNA(Lys)transfer and the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), one of the components of the bacterial membrane with a positive net charge. LPG synthesis contributes to the resistance to cationic antimicrobial peptides (CAMPs) and likely protects M.tuberculosis against the CAMPs produced by competiting microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with positively charged L-lysine results in repulsion of the peptides OLIIENHM_02179 1120797.KB908256_gene2265 2.7e-39 167.9 Mycobacteriaceae Bacteria 239YY@1762,2AI3Y@1,2IHSQ@201174,318HW@2 NA|NA|NA OLIIENHM_02180 710686.Mycsm_03071 1.8e-95 355.5 Mycobacteriaceae infC GO:0000049,GO:0001731,GO:0002181,GO:0002183,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006417,GO:0006446,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016020,GO:0016043,GO:0019222,GO:0019538,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032268,GO:0032270,GO:0032790,GO:0032984,GO:0032988,GO:0032991,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043254,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045727,GO:0045948,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065003,GO:0065007,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901193,GO:1901195,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:1904688,GO:1904690,GO:1990856,GO:1990904,GO:2000112,GO:2000765,GO:2000767 ko:K02520 ko00000,ko03012,ko03029 Bacteria 232MI@1762,2GJGT@201174,COG0290@1,COG0290@2 NA|NA|NA J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins OLIIENHM_02181 47839.CCAU010000009_gene1641 3.6e-25 120.2 Mycobacteriaceae rpmI GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 ko:K02916 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 23B83@1762,2GQZW@201174,COG0291@1,COG0291@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL35 family OLIIENHM_02182 1370120.AUWR01000047_gene2160 1.3e-58 232.3 Mycobacteriaceae rplT GO:0000027,GO:0000900,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0060255,GO:0065003,GO:0065007,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090079,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2000113,GO:2001141 ko:K02887 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 238K0@1762,2IHTN@201174,COG0292@1,COG0292@2 NA|NA|NA J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit OLIIENHM_02183 1440774.Y900_024240 4.1e-91 341.3 Mycobacteriaceae tsnR 2.1.1.185 ko:K03218,ko:K03437 ko00000,ko01000,ko03009,ko03016 Bacteria 234FP@1762,2GJI6@201174,COG0566@1,COG0566@2 NA|NA|NA J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family OLIIENHM_02184 1440774.Y900_024255 7e-114 417.2 Mycobacteriaceae 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1647 Bacteria 232TS@1762,2I900@201174,COG2114@1,COG2114@2 NA|NA|NA T Guanylate cyclase OLIIENHM_02185 931627.MycrhDRAFT_6732 3e-242 844.3 Mycobacteriaceae glt Bacteria 23619@1762,2GME2@201174,COG0069@1,COG0069@2 NA|NA|NA E Belongs to the glutamate synthase family OLIIENHM_02186 1440774.Y900_024270 3.5e-175 620.9 Mycobacteriaceae pheS GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 2346W@1762,2GJGG@201174,COG0016@1,COG0016@2 NA|NA|NA J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily OLIIENHM_02187 931627.MycrhDRAFT_6734 0.0 1374.8 Mycobacteriaceae pheT GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0019538,GO:0019752,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 2347H@1762,2GMFD@201174,COG0072@1,COG0072@2,COG0073@1,COG0073@2 NA|NA|NA J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily OLIIENHM_02188 931627.MycrhDRAFT_3918 2.9e-114 418.3 Mycobacteriaceae Bacteria 232NV@1762,2GU7G@201174,COG1403@1,COG1403@2 NA|NA|NA V Domain of unknown function (DUF222) OLIIENHM_02189 1265310.CCBD010000051_gene2136 4e-151 541.2 Mycobacteriaceae murG GO:0008150,GO:0040007 2.4.1.227,6.3.2.8 ko:K01924,ko:K02563 ko00471,ko00550,ko01100,ko01502,ko04112,map00471,map00550,map01100,map01502,map04112 R03193,R05032,R05662 RC00005,RC00049,RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 GT28 iLJ478.TM0232 Bacteria 2368B@1762,2GJEM@201174,COG0707@1,COG0707@2 NA|NA|NA M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) OLIIENHM_02190 931627.MycrhDRAFT_4026 2.7e-200 704.9 Mycobacteriaceae ftsW GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008360,GO:0009987,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032153,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051179,GO:0051234,GO:0051301,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:1901264,GO:1901505 2.4.1.227 ko:K02563,ko:K03588 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011,ko02000,ko03036 2.A.103.1 GT28 Bacteria 232V1@1762,2GKXP@201174,COG0772@1,COG0772@2 NA|NA|NA D Belongs to the SEDS family OLIIENHM_02191 1440774.Y900_023505 4.6e-200 704.1 Mycobacteriaceae murD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 iNJ661.Rv2155c Bacteria 2329B@1762,2GJZA@201174,COG0771@1,COG0771@2 NA|NA|NA M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) OLIIENHM_02192 1440774.Y900_023500 1e-177 629.4 Mycobacteriaceae mraY GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 iAF987.Gmet_0409,iEC042_1314.EC042_0088,iECABU_c1320.ECABU_c00920,iECED1_1282.ECED1_0088,iECH74115_1262.ECH74115_0095,iECSP_1301.ECSP_0090,iECs_1301.ECs0091,iG2583_1286.G2583_0091,iSDY_1059.SDY_0117,iZ_1308.Z0097,ic_1306.c0105 Bacteria 233TM@1762,2GNEH@201174,COG0472@1,COG0472@2 NA|NA|NA M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan OLIIENHM_02193 931627.MycrhDRAFT_4029 3.6e-213 747.7 Mycobacteriaceae murF GO:0008150,GO:0040007 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 Bacteria 235VV@1762,2GK0Y@201174,COG0770@1,COG0770@2 NA|NA|NA M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein OLIIENHM_02194 1440774.Y900_023490 2.8e-221 774.6 Mycobacteriaceae murE GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.10,6.3.2.13 ko:K01928,ko:K15792 ko00300,ko00550,map00300,map00550 R02788,R04617 RC00064,RC00090,RC00141 ko00000,ko00001,ko01000,ko01011 iNJ661.Rv2158c Bacteria 233ZF@1762,2GIS2@201174,COG0769@1,COG0769@2 NA|NA|NA M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan OLIIENHM_02195 931627.MycrhDRAFT_4031 3.2e-294 1017.3 Mycobacteriaceae ftsI GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008144,GO:0008150,GO:0008658,GO:0008955,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0031224,GO:0031226,GO:0031406,GO:0032153,GO:0033218,GO:0033293,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:1901363,GO:1901681 3.4.16.4 ko:K03587,ko:K08384,ko:K08724,ko:K12552,ko:K12556 ko00550,ko01100,ko01501,map00550,map01100,map01501 ko00000,ko00001,ko01000,ko01011,ko03036 iSSON_1240.SSON_0092 Bacteria 234IB@1762,2GKHH@201174,COG0768@1,COG0768@2 NA|NA|NA M Cell division protein FtsI OLIIENHM_02196 931627.MycrhDRAFT_4032 1.4e-68 266.9 Mycobacteriaceae ftsL ko:K05589,ko:K12065 ko00000,ko02044,ko03036 3.A.7.11.1 Bacteria 2338R@1762,2I3SE@201174,COG2919@1,COG2919@2 NA|NA|NA D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic OLIIENHM_02197 1370120.AUWR01000008_gene314 2.3e-131 475.3 Mycobacteriaceae rsmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 ko:K03438 ko00000,ko01000,ko03009 Bacteria 2331F@1762,2GJGK@201174,COG0275@1,COG0275@2 NA|NA|NA J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA OLIIENHM_02198 1440774.Y900_023470 3.7e-70 270.8 Mycobacteriaceae mraZ GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0040007,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 ko:K03925 ko00000 Bacteria 236FE@1762,2IHUB@201174,COG2001@1,COG2001@2 NA|NA|NA K Belongs to the MraZ family OLIIENHM_02199 931627.MycrhDRAFT_4035 5.5e-52 210.3 Mycobacteriaceae Bacteria 239D9@1762,2E49S@1,2IHN1@201174,32Z5G@2 NA|NA|NA S Protein of unknown function (DUF3040) OLIIENHM_02200 931627.MycrhDRAFT_4036 2.9e-81 308.1 Mycobacteriaceae Bacteria 232GF@1762,2GM3A@201174,COG0454@1,COG0456@2 NA|NA|NA K Acetyltransferase (GNAT) family OLIIENHM_02201 931627.MycrhDRAFT_4037 1.9e-78 298.9 Mycobacteriaceae lppM GO:0002682,GO:0002683,GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0009605,GO:0009607,GO:0030312,GO:0031347,GO:0031348,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044413,GO:0044414,GO:0044419,GO:0044464,GO:0045088,GO:0045824,GO:0048519,GO:0048583,GO:0048585,GO:0050776,GO:0050777,GO:0050789,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0051832,GO:0051833,GO:0052031,GO:0052037,GO:0052167,GO:0052170,GO:0052173,GO:0052200,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136,GO:0080134 Bacteria 23354@1762,2E8DR@1,2GM9C@201174,332S7@2 NA|NA|NA OLIIENHM_02202 1380386.JIAW01000009_gene5278 1.1e-150 539.7 Mycobacteriaceae crtE 2.5.1.1,2.5.1.10,2.5.1.29 ko:K13787 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00365 R01658,R02003,R02061 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 Bacteria 233T5@1762,2GJEK@201174,COG0142@1,COG0142@2 NA|NA|NA H Belongs to the FPP GGPP synthase family OLIIENHM_02203 931627.MycrhDRAFT_4039 2.3e-220 771.5 Mycobacteriaceae mptA GO:0000030,GO:0003674,GO:0003824,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0070085,GO:0071704,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509 ko:K14337,ko:K14339 ko00000,ko01000,ko01003 Bacteria 235SR@1762,2DBIT@1,2GN9J@201174,2Z9GU@2 NA|NA|NA S Carotene biosynthesis associated membrane protein OLIIENHM_02204 1440774.Y900_023435 2.2e-56 224.9 Mycobacteriaceae GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010565,GO:0016310,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050789,GO:0050794,GO:0062012,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:1901363,GO:1901564 Bacteria 2396C@1762,2E0H9@1,2IHPW@201174,32W34@2 NA|NA|NA S transcriptional regulator OLIIENHM_02205 1440774.Y900_023430 1.3e-147 529.6 Mycobacteriaceae Bacteria 2338E@1762,2GJ1J@201174,COG0515@1,COG0515@2 NA|NA|NA KLT serine threonine protein kinase OLIIENHM_02206 1356852.N008_12690 9.2e-38 164.5 Cytophagia Bacteria 28PTG@1,2ZCEQ@2,47W24@768503,4NWVQ@976 NA|NA|NA OLIIENHM_02207 1078020.KEK_06262 6.4e-135 486.9 Mycobacteriaceae aroG GO:0003674,GO:0003824,GO:0003849,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016020,GO:0016043,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0022607,GO:0030145,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0051259,GO:0051260,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:1901576 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv2178c Bacteria 233JQ@1762,2GJBX@201174,COG3200@1,COG3200@2 NA|NA|NA E Belongs to the class-II DAHP synthase family OLIIENHM_02208 1440774.Y900_011875 1e-109 402.9 Mycobacteriaceae Bacteria 232SB@1762,2GIZB@201174,COG0745@1,COG0745@2 NA|NA|NA KT transcriptional OLIIENHM_02209 931627.MycrhDRAFT_2010 1.7e-30 139.0 Mycobacteriaceae Bacteria 239HT@1762,2IQJ3@201174,COG4828@1,COG4828@2 NA|NA|NA S Protein of unknown function (DUF1622) OLIIENHM_02210 1440774.Y900_011890 7.3e-162 577.0 Mycobacteriaceae Bacteria 236SG@1762,2IA2X@201174,COG2966@1,COG2966@2 NA|NA|NA S Putative threonine/serine exporter OLIIENHM_02211 1440774.Y900_011895 2.8e-161 574.7 Mycobacteriaceae Bacteria 23419@1762,2GJT0@201174,COG3173@1,COG3173@2 NA|NA|NA S Aminoglycoside phosphotransferase OLIIENHM_02212 931627.MycrhDRAFT_2013 4.7e-200 703.7 Mycobacteriaceae 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 Bacteria 2368K@1762,2GKQI@201174,COG1960@1,COG1960@2 NA|NA|NA I Acyl-CoA dehydrogenase, C-terminal domain OLIIENHM_02213 931627.MycrhDRAFT_2014 1.6e-113 415.6 Mycobacteriaceae Bacteria 236CE@1762,2GJU1@201174,COG1028@1,COG1028@2 NA|NA|NA IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) OLIIENHM_02214 1299327.I546_2024 1.3e-52 213.0 Mycobacteriaceae GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 Bacteria 23543@1762,2EP2R@1,2IDXG@201174,33GPJ@2 NA|NA|NA OLIIENHM_02215 1157943.KB892706_gene4123 2.7e-108 398.3 Mycobacteriaceae Bacteria 2346E@1762,2GJE6@201174,COG0745@1,COG0745@2 NA|NA|NA T PFAM response regulator receiver OLIIENHM_02216 710421.Mycch_2227 1.3e-149 536.2 Mycobacteriaceae Bacteria 235XS@1762,2GIX7@201174,COG5002@1,COG5002@2 NA|NA|NA T Histidine kinase OLIIENHM_02217 1440774.Y900_013980 2.8e-61 241.9 Mycobacteriaceae Bacteria 2351B@1762,2IKUE@201174,COG3544@1,COG3544@2 NA|NA|NA S Domain of unknown function (DUF305) OLIIENHM_02219 710687.KI912270_gene4586 1.1e-150 539.7 Mycobacteriaceae 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 Bacteria 236CT@1762,2GK6J@201174,COG0031@1,COG0031@2 NA|NA|NA E PFAM Pyridoxal-5'-phosphate-dependent enzyme, beta subunit OLIIENHM_02220 1157943.KB892706_gene4129 2.6e-164 585.1 Mycobacteriaceae yceL ko:K08162 ko00000,ko02000 2.A.1.2.21 Bacteria 2331I@1762,2GK86@201174,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily OLIIENHM_02221 1380347.JNII01000006_gene1845 5.5e-31 141.4 Frankiales ycnI Bacteria 2GN9H@201174,4ESXU@85013,COG4549@1,COG4549@2 NA|NA|NA S nuclear export factor GLE1 OLIIENHM_02222 318424.EU78_27850 3.2e-26 124.8 Mycobacteriaceae 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 Bacteria 23FDB@1762,2I5XI@201174,COG1622@1,COG1622@2 NA|NA|NA C oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor OLIIENHM_02223 318424.EU78_27845 5.1e-174 617.5 Mycobacteriaceae fedB Bacteria 23F70@1762,2I3TS@201174,2Z93M@2,arCOG02771@1 NA|NA|NA OLIIENHM_02224 216594.MMAR_2403 1.7e-178 632.1 Mycobacteriaceae ko:K06987 ko00000 Bacteria 23CR9@1762,2H23I@201174,COG3608@1,COG3608@2 NA|NA|NA S Succinylglutamate desuccinylase / Aspartoacylase family OLIIENHM_02226 216594.MMAR_2405 0.0 1202.6 Actinobacteria cphE4 3.4.15.6 ko:K13282 R09722 RC00064,RC00141 ko00000,ko01000,ko01002 Bacteria 2I93U@201174,COG4242@1,COG4242@2 NA|NA|NA PQ Belongs to the peptidase S51 family OLIIENHM_02227 216594.MMAR_2406 0.0 1618.6 Mycobacteriaceae cphA 6.3.2.13,6.3.2.29,6.3.2.30 ko:K01928,ko:K03802 ko00300,ko00550,map00300,map00550 R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 Bacteria 2356T@1762,2GN0U@201174,COG0189@1,COG0189@2,COG0769@1,COG0769@2 NA|NA|NA HJK acetyltransferase OLIIENHM_02228 216594.MMAR_2407 1.4e-235 822.0 Mycobacteriaceae ko:K03294 ko00000 2.A.3.2 Bacteria 23292@1762,2GJ75@201174,COG0531@1,COG0531@2 NA|NA|NA E amino acid OLIIENHM_02229 931627.MycrhDRAFT_3517 4.6e-109 401.0 Mycobacteriaceae GO:0003674,GO:0003824,GO:0016403,GO:0016787,GO:0016810,GO:0016813 2.6.1.13 ko:K00819 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 R00667 RC00006,RC00062 ko00000,ko00001,ko01000,ko01007 Bacteria 235HW@1762,2GNTN@201174,COG1834@1,COG1834@2 NA|NA|NA E PFAM amidinotransferase OLIIENHM_02230 262316.MAP_2096 1.2e-63 249.2 Mycobacteriaceae ko:K03718,ko:K03719 ko00000,ko03000,ko03036 Bacteria 238JI@1762,2GN6I@201174,COG1522@1,COG1522@2 NA|NA|NA K transcriptional OLIIENHM_02233 1440774.Y900_011955 2.4e-158 565.1 Mycobacteriaceae pat 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 232W7@1762,2GJXS@201174,COG0079@1,COG0079@2 NA|NA|NA E May catalyze the transamination reaction in phenylalanine biosynthesis OLIIENHM_02234 931627.MycrhDRAFT_2020 1.3e-152 545.8 Mycobacteriaceae cysK GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 Bacteria 236GV@1762,2GIXE@201174,COG0031@1,COG0031@2 NA|NA|NA E Belongs to the cysteine synthase cystathionine beta- synthase family OLIIENHM_02235 875328.JDM601_1668 1.8e-91 342.0 Mycobacteriaceae cysE GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009001,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 iJN746.PP_0840 Bacteria 235BW@1762,2IHW5@201174,COG1045@1,COG1045@2 NA|NA|NA E Serine acetyltransferase OLIIENHM_02236 1440774.Y900_011980 2.6e-125 454.9 Mycobacteriaceae Ech1 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 Bacteria 233I6@1762,2GJG7@201174,COG1024@1,COG1024@2 NA|NA|NA I Enoyl-CoA hydratase OLIIENHM_02238 44454.NF84_02205 9.4e-11 71.6 Mycobacteriaceae Bacteria 23988@1762,2IHPH@201174,COG2963@1,COG2963@2 NA|NA|NA L Transposase OLIIENHM_02239 44454.NF84_02205 3.9e-21 106.7 Mycobacteriaceae Bacteria 23988@1762,2IHPH@201174,COG2963@1,COG2963@2 NA|NA|NA L Transposase OLIIENHM_02240 1380386.JIAW01000002_gene5803 1.8e-163 583.2 Mycobacteriaceae Bacteria 23FCH@1762,2I2FR@201174,COG2199@1,COG2199@2 NA|NA|NA T PFAM Diguanylate phosphodiesterase, EAL domain OLIIENHM_02242 1440774.Y900_011995 6.4e-61 240.4 Mycobacteriaceae Bacteria 2350K@1762,2GP6A@201174,COG1846@1,COG1846@2 NA|NA|NA K MarR family transcriptional regulator OLIIENHM_02243 931627.MycrhDRAFT_2026 1.3e-102 379.8 Mycobacteriaceae qor 1.6.5.5 ko:K00344 ko00000,ko01000 Bacteria 232JU@1762,2GN47@201174,COG0604@1,COG0604@2 NA|NA|NA C NAD(P)H quinone oxidoreductase OLIIENHM_02244 931627.MycrhDRAFT_2027 1.8e-159 568.9 Mycobacteriaceae csd GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 Bacteria 232AN@1762,2GKAF@201174,COG0520@1,COG0520@2 NA|NA|NA E cysteine desulfurase family protein OLIIENHM_02245 1440774.Y900_012010 4.2e-270 937.2 Mycobacteriaceae Bacteria 236CH@1762,2HKW0@201174,COG5617@1,COG5617@2 NA|NA|NA S Psort location CytoplasmicMembrane, score OLIIENHM_02246 1440774.Y900_012015 1.4e-69 269.2 Mycobacteriaceae bpa GO:0000502,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010604,GO:0016020,GO:0016043,GO:0019222,GO:0022607,GO:0022624,GO:0030162,GO:0030312,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0032268,GO:0032270,GO:0032991,GO:0042176,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0044877,GO:0045732,GO:0045862,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051259,GO:0051260,GO:0060255,GO:0061136,GO:0065003,GO:0065007,GO:0070628,GO:0071840,GO:0071944,GO:0080090,GO:1901800,GO:1902494,GO:1903050,GO:1903052,GO:1903362,GO:1903364,GO:1905368,GO:1905369 Bacteria 234VH@1762,291ZT@1,2GR7R@201174,2ZPJ4@2 NA|NA|NA S Interacts with the core proteasome alpha-subunit (PrcA) through its C-terminal hydrophobic-tyrosine-X motif (HbYX motif). Interaction of Bpa with the proteasome stimulates proteosomal peptidase and casein degradation activity, which suggests Bpa could play a role in the removal of non-native or damaged proteins by influencing the conformation of the proteasome complex upon interaction OLIIENHM_02247 875328.JDM601_4081 2.4e-131 474.9 Mycobacteriaceae rfbE 3.6.3.38 ko:K01990,ko:K09689,ko:K09691 ko02010,map02010 M00249,M00250,M00254 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.101,3.A.1.103 Bacteria 234Z4@1762,2GIVF@201174,COG1134@1,COG1134@2 NA|NA|NA GM ABC transporter OLIIENHM_02248 931627.MycrhDRAFT_2031 8.5e-141 506.5 Mycobacteriaceae glfT1 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0008378,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016740,GO:0016757,GO:0016758,GO:0034645,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0045229,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:1901576 2.4.1.287 ko:K16649 ko00000,ko01000,ko01003 GT2 Bacteria 235MP@1762,2GMQQ@201174,COG1216@1,COG1216@2 NA|NA|NA S PFAM Glycosyl transferase family 2 OLIIENHM_02249 1440774.Y900_012030 2.3e-137 495.0 Mycobacteriaceae rfbD ko:K01992,ko:K09690 ko02010,map02010 M00250,M00254 ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.103 Bacteria 235KW@1762,2I0Y8@201174,COG1682@1,COG1682@2 NA|NA|NA GM transporter OLIIENHM_02250 1440774.Y900_012035 1.7e-54 218.8 Mycobacteriaceae ko:K07005 ko00000 Bacteria 2397R@1762,2IQ9Y@201174,COG3467@1,COG3467@2 NA|NA|NA S Pyridoxamine 5-phosphate OLIIENHM_02251 1440774.Y900_012040 3.4e-64 251.5 Mycobacteriaceae Bacteria 236SB@1762,2GMYQ@201174,COG4339@1,COG4339@2 NA|NA|NA S protein conserved in bacteria OLIIENHM_02252 710686.Mycsm_06176 1.9e-47 195.3 Mycobacteriaceae Bacteria 239RC@1762,2IGKV@201174,COG2246@1,COG2246@2 NA|NA|NA S capsule polysaccharide biosynthetic process OLIIENHM_02253 1370121.AUWS01000037_gene4613 1.5e-234 818.5 Mycobacteriaceae dprE1 GO:0000271,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010383,GO:0016020,GO:0016051,GO:0031221,GO:0033692,GO:0034637,GO:0034645,GO:0035884,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0070589,GO:0070592,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901576 1.1.98.3 ko:K16653 ko00000,ko01000 Bacteria 232N4@1762,2HXIH@201174,COG0277@1,COG0277@2 NA|NA|NA C FAD linked oxidase OLIIENHM_02254 1209984.BN978_02463 3.4e-127 461.1 Mycobacteriaceae Bacteria 232QA@1762,2I2RJ@201174,COG1028@1,COG1028@2 NA|NA|NA IQ Dehydrogenase OLIIENHM_02255 931627.MycrhDRAFT_2044 5.1e-257 893.6 Mycobacteriaceae aftA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0008194,GO:0008378,GO:0009058,GO:0009059,GO:0009273,GO:0009987,GO:0016020,GO:0016043,GO:0016740,GO:0016757,GO:0016758,GO:0022607,GO:0030312,GO:0034645,GO:0035250,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0045229,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071766,GO:0071769,GO:0071840,GO:0071944,GO:1901576 2.4.2.46 ko:K13686 ko00000,ko01000,ko01003 GT85 Bacteria 235DP@1762,28MYD@1,2GMV7@201174,2ZB59@2 NA|NA|NA M Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor decaprenyl-phospho-arabinose (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases OLIIENHM_02256 931627.MycrhDRAFT_2045 0.0 1706.8 Mycobacteriaceae embC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0052636,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 ko:K11387 ko00000,ko01000,ko01003 Bacteria 232R9@1762,2GKH9@201174,COG1807@1,COG1807@2 NA|NA|NA M Cell wall arabinan synthesis protein OLIIENHM_02258 1440774.Y900_012070 0.0 1637.5 Mycobacteriaceae embA GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016763,GO:0031224,GO:0031226,GO:0040007,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0052636,GO:0071944 ko:K11385 ko00000,ko01000,ko01003 Bacteria 2340K@1762,2GK7Z@201174,COG1807@1,COG1807@2 NA|NA|NA M Cell wall arabinan synthesis protein OLIIENHM_02259 931627.MycrhDRAFT_2047 0.0 1761.9 Mycobacteriaceae embB GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 ko:K11386 ko00000,ko01000,ko01003 Bacteria 2336H@1762,2GKH9@201174,COG1807@1,COG1807@2 NA|NA|NA M Cell wall arabinan synthesis protein OLIIENHM_02260 1440774.Y900_008060 1.1e-149 536.6 Mycobacteriaceae Bacteria 232NV@1762,2GU7G@201174,COG1403@1,COG1403@2 NA|NA|NA V Domain of unknown function (DUF222) OLIIENHM_02261 1108045.GORHZ_164_00470 2.4e-268 931.4 Gordoniaceae crr GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006109,GO:0006793,GO:0006796,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0009401,GO:0009892,GO:0009898,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0019222,GO:0019897,GO:0019898,GO:0031234,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045912,GO:0048519,GO:0050789,GO:0051179,GO:0051234,GO:0065007,GO:0071702,GO:0071944,GO:0080090,GO:0098552,GO:0098562 ko:K02755,ko:K02756,ko:K02757,ko:K02777 ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111 M00265,M00266,M00268,M00270,M00271,M00272,M00303,M00806 R02738,R02780,R04111,R04394,R05132,R08559 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.1,4.A.1.2.11,4.A.1.2.2,4.A.1.2.5,4.A.1.2.6 e_coli_core.b2417,iAF1260.b2417,iAPECO1_1312.APECO1_4128,iB21_1397.B21_02278,iBWG_1329.BWG_2179,iE2348C_1286.E2348C_2603,iEC042_1314.EC042_2626,iEC55989_1330.EC55989_2707,iECABU_c1320.ECABU_c27380,iECBD_1354.ECBD_1264,iECB_1328.ECB_02317,iECDH10B_1368.ECDH10B_2582,iECDH1ME8569_1439.ECDH1ME8569_2351,iECD_1391.ECD_02317,iECED1_1282.ECED1_2861,iECH74115_1262.ECH74115_3648,iECIAI1_1343.ECIAI1_2475,iECIAI39_1322.ECIAI39_2563,iECNA114_1301.ECNA114_2494,iECO103_1326.ECO103_2936,iECO111_1330.ECO111_3147,iECO26_1355.ECO26_3470,iECOK1_1307.ECOK1_2734,iECS88_1305.ECS88_2607,iECSE_1348.ECSE_2708,iECSF_1327.ECSF_2281,iECSP_1301.ECSP_3365,iECUMN_1333.ECUMN_2739,iECW_1372.ECW_m2646,iEKO11_1354.EKO11_1311,iETEC_1333.ETEC_2530,iEcDH1_1363.EcDH1_1244,iEcE24377_1341.EcE24377A_2704,iEcHS_1320.EcHS_A2552,iEcSMS35_1347.EcSMS35_2572,iEcolC_1368.EcolC_1261,iG2583_1286.G2583_2949,iJO1366.b2417,iJR904.b2417,iLF82_1304.LF82_0357,iNRG857_1313.NRG857_12120,iSFV_1184.SFV_2469,iSF_1195.SF2472,iSFxv_1172.SFxv_2721,iSSON_1240.SSON_2506,iS_1188.S2618,iUMN146_1321.UM146_04535,iUMNK88_1353.UMNK88_3019,iUTI89_1310.UTI89_C2751,iWFL_1372.ECW_m2646,iY75_1357.Y75_RS12665,ic_1306.c2952 Bacteria 2GK6B@201174,4GDQJ@85026,COG1263@1,COG1263@2,COG1264@1,COG1264@2,COG2190@1,COG2190@2 NA|NA|NA G phosphotransferase system, EIIB OLIIENHM_02262 1440774.Y900_012095 4.8e-128 464.5 Mycobacteriaceae Bacteria 2334C@1762,2GNT2@201174,COG0515@1,COG0515@2 NA|NA|NA KLT serine threonine protein kinase OLIIENHM_02263 1341646.CBMO010000011_gene948 4.1e-96 357.8 Mycobacteriaceae Bacteria 2365R@1762,2I3U4@201174,COG1846@1,COG1846@2 NA|NA|NA K Transcriptional regulator OLIIENHM_02264 1157943.KB892705_gene89 5.3e-75 287.3 Mycobacteriaceae Bacteria 233PS@1762,2IB85@201174,COG2128@1,COG2128@2 NA|NA|NA S Carboxymuconolactone decarboxylase OLIIENHM_02265 1157943.KB892705_gene87 4.5e-109 401.0 Mycobacteriaceae ko:K07124 ko00000 Bacteria 237T2@1762,2GKJE@201174,COG0300@1,COG0300@2 NA|NA|NA S Belongs to the short-chain dehydrogenases reductases (SDR) family OLIIENHM_02266 1157943.KB892705_gene86 3.5e-143 515.0 Mycobacteriaceae 2.3.1.20 ko:K00635 ko00561,ko01100,map00561,map01100 M00089 R02251 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 Bacteria 23579@1762,2GKGU@201174,COG1020@1,COG1020@2 NA|NA|NA I Belongs to the long-chain O-acyltransferase family OLIIENHM_02267 1157943.KB892705_gene85 5.1e-181 640.6 Mycobacteriaceae papA5 GO:0003674,GO:0003824,GO:0006629,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0009058,GO:0009273,GO:0009987,GO:0016043,GO:0016740,GO:0016746,GO:0016747,GO:0022607,GO:0042546,GO:0044085,GO:0044238,GO:0071554,GO:0071704,GO:0071766,GO:0071770,GO:0071840,GO:1901576 Bacteria 235YS@1762,2IA81@201174,COG1020@1,COG1020@2 NA|NA|NA Q Catalyzes diesterification of phthiocerol and phthiodiolone with mycocerosic acids, the final step in the phthiocerol and phthiodiolone dimycocerosate esters (PDIM) synthesis. Can directly transfer the mycocerosate bound to the mycocerosic acid synthase (mas) onto the substrate alcohols OLIIENHM_02268 1157943.KB892705_gene84 1e-105 389.8 Mycobacteriaceae drrC GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0008150,GO:0009605,GO:0009607,GO:0030312,GO:0040007,GO:0043207,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071944,GO:0075136 ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 234EC@1762,2I5GM@201174,COG0842@1,COG0842@2 NA|NA|NA V Transport permease protein OLIIENHM_02269 1157943.KB892705_gene83 1.5e-128 465.7 Mycobacteriaceae drrB GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006810,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009273,GO:0009987,GO:0016020,GO:0016043,GO:0022607,GO:0042221,GO:0042546,GO:0044085,GO:0044238,GO:0044464,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071554,GO:0071704,GO:0071766,GO:0071770,GO:0071840,GO:0071944,GO:1901576 ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 235EB@1762,2IKB4@201174,COG0842@1,COG0842@2 NA|NA|NA V Transporter OLIIENHM_02270 1157943.KB892705_gene82 1.1e-138 499.6 Mycobacteriaceae drrA GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008144,GO:0008150,GO:0010876,GO:0016020,GO:0017076,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0033036,GO:0035639,GO:0036094,GO:0040007,GO:0042221,GO:0043167,GO:0043168,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0051704,GO:0055085,GO:0071702,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363 ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 233G9@1762,2GIY8@201174,COG1131@1,COG1131@2 NA|NA|NA V ABC transporter OLIIENHM_02271 1157943.KB892705_gene81 0.0 2192.5 Mycobacteriaceae ppsE GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009273,GO:0009987,GO:0016020,GO:0016043,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0030312,GO:0032787,GO:0032991,GO:0034081,GO:0042546,GO:0043436,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071554,GO:0071704,GO:0071766,GO:0071770,GO:0071840,GO:0071944,GO:0072330,GO:1901576 ko:K12444,ko:K15328 ko00000,ko01004,ko01008 Bacteria 234TD@1762,2GISR@201174,COG1020@1,COG1020@2,COG3321@1,COG3321@2 NA|NA|NA Q synthase OLIIENHM_02272 1157943.KB892705_gene80 0.0 2220.7 Mycobacteriaceae ppsA GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006725,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009273,GO:0009987,GO:0016043,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0018958,GO:0019438,GO:0019751,GO:0019752,GO:0022607,GO:0032787,GO:0032991,GO:0034081,GO:0034311,GO:0034312,GO:0042546,GO:0042844,GO:0042845,GO:0043436,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046173,GO:0046189,GO:0046394,GO:0071554,GO:0071704,GO:0071766,GO:0071770,GO:0071840,GO:0072330,GO:0097040,GO:0097041,GO:1901360,GO:1901362,GO:1901576,GO:1901615,GO:1901617 ko:K12440,ko:K12441 ko00000,ko01004 Bacteria 232E7@1762,2H477@201174,COG3321@1,COG3321@2 NA|NA|NA Q polyketide synthase OLIIENHM_02273 557599.MKAN_24045 3.7e-201 708.0 Mycobacteriaceae fadD26 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006066,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009273,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016043,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0016874,GO:0016877,GO:0016878,GO:0019751,GO:0019752,GO:0022607,GO:0032787,GO:0034311,GO:0034312,GO:0040007,GO:0042546,GO:0042844,GO:0042845,GO:0043207,GO:0043436,GO:0044085,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044403,GO:0044419,GO:0044464,GO:0046165,GO:0046173,GO:0046394,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0070566,GO:0071554,GO:0071704,GO:0071766,GO:0071770,GO:0071840,GO:0071944,GO:0072330,GO:0075136,GO:0097040,GO:1901576,GO:1901615,GO:1901617 2.7.7.95,6.2.1.51 ko:K00666,ko:K12426,ko:K12427,ko:K12428,ko:K21059 R11537,R11538,R11922,R11923,R11924,R11925 RC00043 ko00000,ko01000,ko01004 Bacteria 2343A@1762,2I2RH@201174,COG0318@1,COG0318@2 NA|NA|NA IQ Activates fatty acids by binding to coenzyme A OLIIENHM_02274 1157943.KB892705_gene78 2.5e-100 371.7 Mycobacteriaceae tesA GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009273,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016043,GO:0022607,GO:0035821,GO:0042546,GO:0043207,GO:0044003,GO:0044085,GO:0044238,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0071554,GO:0071704,GO:0071766,GO:0071770,GO:0071840,GO:0071944,GO:0075136,GO:1901576 iNJ661.Rv2928 Bacteria 2370H@1762,2GMY8@201174,COG3208@1,COG3208@2 NA|NA|NA Q thioesterase OLIIENHM_02275 1440774.Y900_012140 1.5e-270 938.3 Mycobacteriaceae pccB 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 Bacteria 234EU@1762,2GJMT@201174,COG4799@1,COG4799@2 NA|NA|NA I Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) OLIIENHM_02276 1440774.Y900_012145 0.0 2750.3 Mycobacteriaceae pks13 ko:K12437,ko:K13614,ko:K13615,ko:K15679 ko00000,ko01004,ko01008 Bacteria 232CX@1762,2HEN2@201174,COG0236@1,COG0236@2,COG3319@1,COG3319@2,COG3321@1,COG3321@2 NA|NA|NA Q synthase OLIIENHM_02277 931627.MycrhDRAFT_2058 0.0 1107.8 Mycobacteriaceae fadD32 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009273,GO:0009987,GO:0016020,GO:0016043,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0016874,GO:0019752,GO:0022607,GO:0030312,GO:0032787,GO:0040007,GO:0042546,GO:0043436,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070566,GO:0071554,GO:0071704,GO:0071766,GO:0071769,GO:0071840,GO:0071944,GO:0072330,GO:1901576 ko:K12428 ko00000,ko01004 iNJ661.Rv3801c Bacteria 232A6@1762,2I2RH@201174,COG0318@1,COG0318@2 NA|NA|NA IQ Activates fatty acids by binding to coenzyme A OLIIENHM_02278 350058.Mvan_5642 4.5e-130 471.1 Mycobacteriaceae elrF Bacteria 232Q8@1762,2GKXK@201174,COG4223@1,COG4223@2 NA|NA|NA S cutinase OLIIENHM_02279 1440774.Y900_012160 6e-27 127.5 Mycobacteriaceae Bacteria 23AZ1@1762,2AXUC@1,2IRAE@201174,31PVG@2 NA|NA|NA OLIIENHM_02280 931627.MycrhDRAFT_2061 3e-122 444.9 Mycobacteriaceae fbpB 2.3.1.122,2.3.1.20 ko:K18851 ko00561,ko01100,map00561,map01100 M00089 R02251 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 Bacteria 233CW@1762,2GJX4@201174,COG0627@1,COG0627@2 NA|NA|NA S esterase OLIIENHM_02281 931627.MycrhDRAFT_2064 3.7e-268 930.6 Mycobacteriaceae aftB GO:0008150,GO:0040007 ko:K13687 ko00000,ko01000,ko01003 GT89 Bacteria 233IY@1762,2GNPY@201174,COG1807@1,COG1807@2 NA|NA|NA M capsule polysaccharide biosynthetic process OLIIENHM_02282 164757.Mjls_5398 1.1e-132 479.6 Mycobacteriaceae ubiA GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016763,GO:0031224,GO:0031226,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0046467,GO:0046872,GO:0052636,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.4.2.45 ko:K14136 R10095 RC00005 ko00000,ko01000,ko01006 Bacteria 234D3@1762,2GJ6P@201174,COG0382@1,COG0382@2 NA|NA|NA H Catalyzes the formation of decaprenylphosphoryl-5-phosphoribose from phosphoribose diphosphate and decaprenyl phosphate OLIIENHM_02283 931627.MycrhDRAFT_2066 1.2e-57 229.6 Mycobacteriaceae 3.6.1.27 ko:K19302 ko00550,map00550 R05627 RC00002 ko00000,ko00001,ko01000,ko01011 Bacteria 238N3@1762,2IIA1@201174,COG0671@1,COG0671@2 NA|NA|NA I Membrane-associated phospholipid phosphatase OLIIENHM_02284 1122247.C731_4116 7.7e-301 1039.3 Mycobacteriaceae glfT GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005976,GO:0006139,GO:0006629,GO:0006725,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0008194,GO:0008378,GO:0008610,GO:0008653,GO:0008921,GO:0009058,GO:0009059,GO:0009103,GO:0009225,GO:0009273,GO:0009987,GO:0010383,GO:0016020,GO:0016043,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0022607,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0035250,GO:0035496,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045229,GO:0046483,GO:0052573,GO:0055086,GO:0070589,GO:0070592,GO:0071554,GO:0071555,GO:0071704,GO:0071766,GO:0071769,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901576,GO:1903509 2.4.1.288 ko:K16650 ko00000,ko01000,ko01003 GT2 iNJ661.Rv3808c Bacteria 2337D@1762,2GM9N@201174,COG1216@1,COG1216@2 NA|NA|NA S transferase OLIIENHM_02285 164757.Mjls_5401 1.3e-208 732.3 Mycobacteriaceae glf GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008767,GO:0009273,GO:0009987,GO:0016020,GO:0016853,GO:0016866,GO:0030312,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0071554,GO:0071766,GO:0071840,GO:0071944,GO:0097159,GO:1901265,GO:1901363 5.4.99.9 ko:K01854 ko00052,ko00520,map00052,map00520 R00505,R09009 RC00317,RC02396 ko00000,ko00001,ko01000 iNJ661.Rv3809c Bacteria 232IV@1762,2GK2Z@201174,COG0562@1,COG0562@2 NA|NA|NA M UDP-galactopyranose mutase OLIIENHM_02286 931627.MycrhDRAFT_2069 6.8e-43 181.4 Mycobacteriaceae ompC Bacteria 23F7Q@1762,2I4HC@201174,COG5263@1,COG5263@2 NA|NA|NA S GLTT repeat (6 copies) OLIIENHM_02287 1440774.Y900_012210 1.7e-237 828.6 Mycobacteriaceae lytC Bacteria 232E8@1762,2GNDB@201174,COG5479@1,COG5479@2 NA|NA|NA M N-acetylmuramoyl-L-alanine amidase OLIIENHM_02288 47839.CCAU010000002_gene2346 5.6e-253 880.2 Mycobacteriaceae cbbX Bacteria 233R6@1762,2GJWA@201174,COG0464@1,COG0464@2 NA|NA|NA O Type VII secretion OLIIENHM_02289 47839.CCAU010000002_gene2347 5.3e-140 504.6 Mycobacteriaceae GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 2357A@1762,2BMYI@1,2I99R@201174,32GIB@2 NA|NA|NA S Putative type VII ESX secretion system translocon, EccE OLIIENHM_02290 1265310.CCBD010000073_gene327 8.3e-157 560.5 Mycobacteriaceae mycP GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K14645,ko:K14743 ko02024,map02024 ko00000,ko00001,ko01000,ko01002,ko03110 Bacteria 234HB@1762,2GIRE@201174,COG1404@1,COG1404@2 NA|NA|NA O Peptidase S8 OLIIENHM_02291 47839.CCAU010000002_gene2350 1.1e-145 523.5 Mycobacteriaceae eccD2 GO:0008150,GO:0009605,GO:0009607,GO:0020012,GO:0030682,GO:0042783,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0075136 Bacteria 236GT@1762,2B6TY@1,2I9UZ@201174,31ZT9@2 NA|NA|NA S WXG100 protein secretion system (Wss), protein YukD OLIIENHM_02292 1265310.CCBD010000073_gene324 3.2e-138 498.0 Mycobacteriaceae Bacteria 23612@1762,2I9AJ@201174,COG0455@1,COG0455@2 NA|NA|NA D bacterial-type flagellum organization OLIIENHM_02293 1265310.CCBD010000073_gene323 1.7e-71 276.2 Mycobacteriaceae Bacteria 2385A@1762,2A2YZ@1,2IDFZ@201174,30RDF@2 NA|NA|NA S EspG family OLIIENHM_02294 1265310.CCBD010000073_gene322 2.1e-21 108.2 Mycobacteriaceae esxC Bacteria 23B2D@1762,2IT6A@201174,329MM@2,COG4842@1 NA|NA|NA S Belongs to the WXG100 family OLIIENHM_02295 875328.JDM601_0054 1.4e-15 89.0 Mycobacteriaceae esxD Bacteria 239WI@1762,2A33T@1,2INXK@201174,30RIW@2 NA|NA|NA S Proteins of 100 residues with WXG OLIIENHM_02296 1265310.CCBD010000070_gene279 1.7e-46 193.7 Mycobacteriaceae PPE69 Bacteria 235PZ@1762,2H3B3@201174,COG5651@1,COG5651@2 NA|NA|NA N PPE family OLIIENHM_02297 1265310.CCBD010000070_gene280 1.7e-10 72.0 Mycobacteriaceae PE36 Bacteria 23AKV@1762,2AY4M@1,2IRPB@201174,31Q6I@2 NA|NA|NA S PE family OLIIENHM_02298 1032480.MLP_10710 2.5e-88 332.4 Propionibacteriales ko:K02012 ko02010,map02010 M00190 ko00000,ko00001,ko00002,ko02000 3.A.1.10 Bacteria 2HZ71@201174,4DQ1H@85009,COG1840@1,COG1840@2 NA|NA|NA P Bacterial extracellular solute-binding protein OLIIENHM_02299 1906.SFRA_07875 6.2e-115 421.4 Actinobacteria sfuB ko:K02011 ko02010,map02010 M00190 ko00000,ko00001,ko00002,ko02000 3.A.1.10 Bacteria 2GKPT@201174,COG1178@1,COG1178@2 NA|NA|NA P Binding-protein-dependent transport systems inner membrane component OLIIENHM_02300 58123.JOFJ01000026_gene2710 7.8e-85 320.9 Streptosporangiales fbpC 3.6.3.30 ko:K02010 ko02010,map02010 M00190 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10 Bacteria 2GJCM@201174,4EGCX@85012,COG3842@1,COG3842@2 NA|NA|NA E TOBE domain OLIIENHM_02301 931627.MycrhDRAFT_2636 1.9e-33 148.3 Mycobacteriaceae Bacteria 23A5F@1762,2DP0M@1,2GQYW@201174,3301T@2 NA|NA|NA OLIIENHM_02302 318424.EU78_01565 3.4e-141 507.7 Mycobacteriaceae Bacteria 233C0@1762,2CEY7@1,2GKI0@201174,2Z8CG@2 NA|NA|NA S membrane OLIIENHM_02304 710687.KI912270_gene2901 3.1e-79 301.2 Mycobacteriaceae fadE8 ko:K09456 ko00000 Bacteria 232AI@1762,2GJHM@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_02305 1440774.Y900_017955 1.1e-153 549.3 Mycobacteriaceae echA4 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 Bacteria 233AK@1762,2GN3P@201174,COG1024@1,COG1024@2 NA|NA|NA I Enoyl-CoA hydratase OLIIENHM_02306 164757.Mjls_1005 5.7e-92 344.0 Mycobacteriaceae paaX ko:K02616 ko00000,ko03000 Bacteria 2343W@1762,2HHB2@201174,COG3327@1,COG3327@2 NA|NA|NA K protein C-terminal domain OLIIENHM_02307 1370125.AUWT01000007_gene5289 9.6e-114 416.4 Mycobacteriaceae echA5 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 Bacteria 232R8@1762,2GJ63@201174,COG1024@1,COG1024@2 NA|NA|NA I Belongs to the enoyl-CoA hydratase isomerase family OLIIENHM_02308 1370125.AUWT01000007_gene5283 1.8e-148 532.3 Mycobacteriaceae Bacteria 2333U@1762,2IBZD@201174,COG0463@1,COG0463@2 NA|NA|NA M Glycosyl transferase family 2 OLIIENHM_02309 1120746.CCNL01000014_gene2169 1.1e-110 406.8 Bacteria Bacteria COG0463@1,COG0463@2 NA|NA|NA M Glycosyl transferase, family 2 OLIIENHM_02310 258533.BN977_04522 8e-10 70.1 Mycobacteriaceae Bacteria 239AU@1762,295VX@1,2IHSG@201174,2ZT6X@2 NA|NA|NA S Protein of unknown function (DUF3060) OLIIENHM_02311 1440774.Y900_017980 5.1e-89 334.0 Mycobacteriaceae Bacteria 233SD@1762,2I31S@201174,COG1309@1,COG1309@2 NA|NA|NA K tetR family OLIIENHM_02312 710685.MycrhN_0730 8.7e-60 236.1 Mycobacteriaceae rpsL GO:0000372,GO:0000375,GO:0000376,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008380,GO:0009058,GO:0009059,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010604,GO:0010628,GO:0015935,GO:0016070,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0031323,GO:0031325,GO:0032991,GO:0033120,GO:0034336,GO:0034337,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043484,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990145,GO:1990904 ko:K02950 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 238PZ@1762,2IHUF@201174,COG0048@1,COG0048@2 NA|NA|NA J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit OLIIENHM_02313 1172186.KB911466_gene1487 1.5e-80 305.4 Mycobacteriaceae rpsG GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0016020,GO:0016043,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 ko:K02992 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 23327@1762,2GMVW@201174,COG0049@1,COG0049@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA OLIIENHM_02314 525368.HMPREF0591_3782 0.0 1146.3 Mycobacteriaceae fusA GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0030312,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02355 ko00000,ko03012,ko03029 Bacteria 234DS@1762,2GKB3@201174,COG0480@1,COG0480@2 NA|NA|NA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome OLIIENHM_02316 1440774.Y900_013960 4.4e-125 454.5 Mycobacteriaceae 1.17.1.1 ko:K00523 ko00520,map00520 R03391,R03392 RC00230 ko00000,ko00001,ko01000 Bacteria 233WZ@1762,2GJSW@201174,COG1018@1,COG1018@2 NA|NA|NA C Oxidoreductase FAD-binding domain OLIIENHM_02317 1440774.Y900_013955 1.3e-96 359.4 Mycobacteriaceae desT ko:K22105 ko00000,ko03000 Bacteria 233BH@1762,2II2F@201174,COG1309@1,COG1309@2 NA|NA|NA K tetR family OLIIENHM_02318 1440774.Y900_013945 1.3e-80 306.2 Mycobacteriaceae ribG 1.1.1.193,3.5.4.26 ko:K00082,ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 Bacteria 23EYT@1762,2IK6T@201174,COG1985@1,COG1985@2 NA|NA|NA H RibD C-terminal domain OLIIENHM_02319 1440774.Y900_013935 0.0 1291.2 Mycobacteriaceae glgX 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 ko00000,ko00001,ko00002,ko01000 CBM48,GH13 Bacteria 23324@1762,2GJ00@201174,COG1523@1,COG1523@2 NA|NA|NA G Belongs to the glycosyl hydrolase 13 family OLIIENHM_02320 1380386.JIAW01000005_gene1582 1.3e-271 942.2 Mycobacteriaceae 1.14.13.84 ko:K14520 ko00363,ko01100,ko01120,map00363,map01100,map01120 R06892 RC01644 ko00000,ko00001,ko01000 Bacteria 2336S@1762,2GJEA@201174,COG2072@1,COG2072@2 NA|NA|NA P Flavoprotein involved in K transport OLIIENHM_02321 246196.MSMEI_4251 2.2e-140 505.4 Mycobacteriaceae ko:K03791 ko00000 GH19 Bacteria 2356F@1762,2GNJB@201174,COG0739@1,COG0739@2 NA|NA|NA M Domain of unknown function (DUF4185) OLIIENHM_02322 1440774.Y900_013925 1.9e-88 332.0 Mycobacteriaceae Bacteria 2354F@1762,2I9Y3@201174,COG0454@1,COG0456@2 NA|NA|NA K acetyltransferase OLIIENHM_02323 1440774.Y900_013910 5.4e-19 100.5 Mycobacteriaceae Bacteria 236QK@1762,2GJSM@201174,COG1914@1,COG1914@2 NA|NA|NA P Natural resistance-associated macrophage protein OLIIENHM_02324 1440774.Y900_003785 2.8e-36 157.5 Mycobacteriaceae ko:K07005 ko00000 Bacteria 23F78@1762,2I3IN@201174,COG0748@1,COG0748@2 NA|NA|NA P Pyridoxamine 5'-phosphate oxidase OLIIENHM_02327 1440774.Y900_003800 8.7e-236 822.8 Mycobacteriaceae gltX GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 iNJ661.Rv2992c Bacteria 23470@1762,2GJJS@201174,COG0008@1,COG0008@2 NA|NA|NA J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) OLIIENHM_02328 931627.MycrhDRAFT_1889 1.1e-133 482.6 Mycobacteriaceae Bacteria 234SJ@1762,2GN2G@201174,COG0179@1,COG0179@2 NA|NA|NA Q 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase OLIIENHM_02329 1440774.Y900_003810 1.5e-150 539.3 Mycobacteriaceae GO:0005575,GO:0005576 Bacteria 234IH@1762,2H9HJ@201174,COG2271@1,COG2271@2 NA|NA|NA G Major facilitator superfamily OLIIENHM_02330 1341646.CBMO010000072_gene1365 7e-160 570.1 Mycobacteriaceae leuB GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044464,GO:0055114 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2335X@1762,2GK44@201174,COG0473@1,COG0473@2 NA|NA|NA CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate OLIIENHM_02331 1440774.Y900_003820 2.1e-251 874.8 Mycobacteriaceae serA GO:0003674,GO:0003824,GO:0004617,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2333T@1762,2GJGA@201174,COG0111@1,COG0111@2 NA|NA|NA E D-isomer specific 2-hydroxyacid dehydrogenase OLIIENHM_02332 262316.MAP_3034 1.1e-216 759.2 Mycobacteriaceae Bacteria 232KJ@1762,2GJ80@201174,COG1233@1,COG1233@2 NA|NA|NA Q Dehydrogenase OLIIENHM_02334 557599.MKAN_28275 1.8e-35 156.8 Mycobacteriaceae Bacteria 238UF@1762,2IH3W@201174,COG1196@1,COG1196@2 NA|NA|NA D coiled-coil structural protein OLIIENHM_02336 710421.Mycch_1841 3.5e-180 637.5 Mycobacteriaceae ilvC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0008677,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 Bacteria 233H8@1762,2GKXA@201174,COG0059@1,COG0059@2 NA|NA|NA EH Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate OLIIENHM_02337 931627.MycrhDRAFT_1881 1.3e-74 285.8 Mycobacteriaceae ilvN GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0030312,GO:0032991,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 iECO103_1326.ilvN,iJN678.ilvN Bacteria 235KD@1762,2GJCH@201174,COG0440@1,COG0440@2 NA|NA|NA E acetolactate synthase, small OLIIENHM_02338 1209984.BN978_04685 4.4e-301 1040.0 Mycobacteriaceae ilvB GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030312,GO:0030976,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv3003c Bacteria 234DZ@1762,2GKU4@201174,COG0028@1,COG0028@2 NA|NA|NA H Acetolactate synthase, large subunit OLIIENHM_02339 258533.BN977_05424 5.3e-27 127.1 Mycobacteriaceae cfp6 GO:0005575,GO:0005576 Bacteria 23A3R@1762,2EKMU@1,2GR8C@201174,33EBJ@2 NA|NA|NA S Bacterial PH domain OLIIENHM_02340 1440774.Y900_003850 9.9e-102 376.7 Mycobacteriaceae mhqP ko:K15977 ko00000 Bacteria 234A7@1762,2GJCF@201174,COG2259@1,COG2259@2 NA|NA|NA S membrane OLIIENHM_02341 931627.MycrhDRAFT_1877 5e-167 594.0 Mycobacteriaceae lppZ Bacteria 232AQ@1762,2IGAB@201174,COG2133@1,COG2133@2 NA|NA|NA G Glucose / Sorbosone dehydrogenase OLIIENHM_02342 557599.MKAN_15220 1.3e-168 599.4 Mycobacteriaceae ko:K21200 ko00000,ko00199 Bacteria 232NY@1762,2HZR8@201174,COG2124@1,COG2124@2 NA|NA|NA Q cytochrome p450 OLIIENHM_02343 1440774.Y900_003925 7.4e-123 446.8 Mycobacteriaceae Bacteria 2364Z@1762,2EX3P@1,2HIGI@201174,33QEP@2 NA|NA|NA OLIIENHM_02344 1370121.AUWS01000022_gene6269 3.5e-170 604.4 Mycobacteriaceae Bacteria 236E8@1762,2GMGG@201174,COG3391@1,COG3391@2 NA|NA|NA S amine dehydrogenase activity OLIIENHM_02345 1440774.Y900_003935 2.7e-128 464.9 Mycobacteriaceae ko:K05710 ko00360,ko01120,ko01220,map00360,map01120,map01220 M00545 R06782,R06783 RC00098 br01602,ko00000,ko00001,ko00002 Bacteria 235NT@1762,2GKHD@201174,COG0694@1,COG0694@2,COG2146@1,COG2146@2 NA|NA|NA OP COG0694 Thioredoxin-like proteins and domains OLIIENHM_02346 1440774.Y900_003940 2e-148 532.3 Mycobacteriaceae Bacteria 23532@1762,2GNKM@201174,COG0457@1,COG0457@2 NA|NA|NA S Tetratricopeptide repeat OLIIENHM_02347 1440774.Y900_003945 9.7e-24 115.9 Mycobacteriaceae Bacteria 23BAA@1762,28RVZ@1,2GQTU@201174,2ZE88@2 NA|NA|NA OLIIENHM_02348 710687.KI912270_gene4337 1.3e-116 426.0 Mycobacteriaceae hybD ko:K03605 ko00000,ko01000,ko01002 Bacteria 235GT@1762,2I0M8@201174,COG0680@1,COG0680@2 NA|NA|NA C Hydrogenase maturation protease OLIIENHM_02349 1440774.Y900_003955 4.9e-293 1013.1 Mycobacteriaceae hupL 1.12.99.6 ko:K06281 ko00633,ko01120,map00633,map01120 R08034 RC00250 ko00000,ko00001,ko01000 Bacteria 236A3@1762,2GKQY@201174,COG0374@1,COG0374@2 NA|NA|NA C Ni,Fe-hydrogenase I large subunit OLIIENHM_02350 1440774.Y900_003960 5.8e-172 610.1 Mycobacteriaceae hybA 1.12.99.6 ko:K06282 ko00633,ko01120,map00633,map01120 R08034 RC00250 ko00000,ko00001,ko01000 Bacteria 232BY@1762,2GKF2@201174,COG1740@1,COG1740@2 NA|NA|NA C NADH ubiquinone oxidoreductase, 20 OLIIENHM_02351 1440774.Y900_003975 2.1e-182 645.2 Mycobacteriaceae 2.7.13.3 ko:K02480 ko00000,ko01000,ko01001,ko02022 Bacteria 234US@1762,2GJKG@201174,COG2203@1,COG2203@2,COG4585@1,COG4585@2 NA|NA|NA T Histidine kinase OLIIENHM_02352 931627.MycrhDRAFT_1850 1.8e-100 372.1 Mycobacteriaceae Bacteria 232WG@1762,2GKBX@201174,COG2197@1,COG2197@2 NA|NA|NA T response regulator OLIIENHM_02353 1440774.Y900_003985 4.6e-33 147.9 Mycobacteriaceae Bacteria 2337M@1762,2GMIQ@201174,COG0637@1,COG0637@2 NA|NA|NA S haloacid dehalogenase OLIIENHM_02354 931627.MycrhDRAFT_1848 1.8e-257 894.8 Mycobacteriaceae gatB GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 Bacteria 233NV@1762,2GJJH@201174,COG0064@1,COG0064@2 NA|NA|NA J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) OLIIENHM_02355 1120797.KB908267_gene3289 1.2e-70 273.1 Mycobacteriaceae 3.1.1.74 ko:K08095 ko00000,ko01000 Bacteria 23658@1762,2A1QU@1,2HZKA@201174,30PZC@2 NA|NA|NA M Cutinase OLIIENHM_02356 1440774.Y900_003995 1.6e-180 638.6 Mycobacteriaceae pfkA GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 2.7.1.11,2.7.1.90 ko:K00850,ko:K02351,ko:K07245,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko02000,ko03019 9.B.62.1 Bacteria 23405@1762,2GK6W@201174,COG0205@1,COG0205@2 NA|NA|NA F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis OLIIENHM_02357 1440774.Y900_008035 1.6e-153 548.9 Mycobacteriaceae 3.5.1.24 ko:K01442 ko00120,ko00121,ko01100,map00120,map00121,map01100 R02797,R03975,R03977,R04486,R04487,R05835 RC00090,RC00096 ko00000,ko00001,ko01000 Bacteria 236BW@1762,2GK9Z@201174,COG3049@1,COG3049@2 NA|NA|NA M Choloylglycine hydrolase OLIIENHM_02358 931627.MycrhDRAFT_1843 1.1e-249 869.0 Mycobacteriaceae gatA GO:0008150,GO:0040007 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 Bacteria 233DZ@1762,2GJK5@201174,COG0154@1,COG0154@2 NA|NA|NA J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) OLIIENHM_02359 1440774.Y900_004005 1.6e-35 155.2 Mycobacteriaceae gatC GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 Bacteria 239Z5@1762,2IQJN@201174,COG0721@1,COG0721@2 NA|NA|NA J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) OLIIENHM_02360 710686.Mycsm_02228 4.6e-96 357.5 Mycobacteriaceae 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 Bacteria 232V0@1762,2GNRE@201174,COG0317@1,COG0317@2 NA|NA|NA KT Amino acid-binding OLIIENHM_02361 1440774.Y900_004015 0.0 1154.0 Mycobacteriaceae ligA GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016874,GO:0016886,GO:0030312,GO:0033554,GO:0034641,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 Bacteria 232MT@1762,2GJUY@201174,COG0272@1,COG0272@2 NA|NA|NA L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA OLIIENHM_02362 216594.MMAR_2571 1.7e-245 855.1 Mycobacteriaceae gabD2 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009013,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016620,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0071944,GO:0072350 1.2.1.16,1.2.1.20,1.2.1.79,1.2.99.10 ko:K00135,ko:K22445 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 Bacteria 2338K@1762,2GJ95@201174,COG1012@1,COG1012@2 NA|NA|NA C Belongs to the aldehyde dehydrogenase family OLIIENHM_02363 318424.EU78_09565 5.7e-130 470.7 Mycobacteriaceae 2.1.1.14 ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R04405,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 Bacteria 235IR@1762,2GMPS@201174,COG0620@1,COG0620@2 NA|NA|NA E Methionine synthase OLIIENHM_02364 246196.MSMEI_2298 1.2e-167 595.9 Mycobacteriaceae mnmA 2.8.1.13 ko:K00566 ko04122,map04122 R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 Bacteria 235TN@1762,2GIUQ@201174,COG0482@1,COG0482@2 NA|NA|NA J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 OLIIENHM_02365 1440774.Y900_004050 3.4e-174 617.8 Mycobacteriaceae iscS GO:0003674,GO:0003824,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0016783,GO:0022607,GO:0031071,GO:0031163,GO:0040007,GO:0044085,GO:0044237,GO:0051186,GO:0071840 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 Bacteria 233F0@1762,2GKUT@201174,COG1104@1,COG1104@2 NA|NA|NA E Cysteine desulfurase OLIIENHM_02366 931627.MycrhDRAFT_1826 7.3e-143 513.5 Mycobacteriaceae etfA GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 ko:K03522 ko00000,ko04147 Bacteria 233G5@1762,2GJWH@201174,COG2025@1,COG2025@2 NA|NA|NA C Electron transfer flavoprotein OLIIENHM_02367 931627.MycrhDRAFT_1825 1e-126 459.5 Mycobacteriaceae etfB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016020,GO:0016491,GO:0016627,GO:0016628,GO:0022900,GO:0030312,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071944,GO:0071949,GO:0097159,GO:1901265,GO:1901363 1.3.1.108 ko:K03521,ko:K22431 ko00000,ko01000 iAF987.Gmet_2067,iHN637.CLJU_RS19405 Bacteria 23400@1762,2GKV6@201174,COG2086@1,COG2086@2 NA|NA|NA C Electron transfer flavoprotein OLIIENHM_02368 931627.MycrhDRAFT_1824 1.1e-109 402.9 Mycobacteriaceae GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016020,GO:0016740,GO:0016741,GO:0032259,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.1.1.222,2.1.1.64 ko:K00568 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04988,R05614,R08769,R08781 RC00003,RC00392,RC01895 ko00000,ko00001,ko00002,ko01000 Bacteria 232UJ@1762,2GMMX@201174,COG2227@1,COG2227@2 NA|NA|NA H Methyltransferase OLIIENHM_02369 1440774.Y900_004080 1.9e-273 948.0 Mycobacteriaceae GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 2.4.1.18 ko:K03406,ko:K16149 ko00500,ko01100,ko01110,ko02020,ko02030,map00500,map01100,map01110,map02020,map02030 M00565 R02110 ko00000,ko00001,ko00002,ko01000,ko02035 GH57 Bacteria 2333G@1762,2GKTI@201174,COG1543@1,COG1543@2 NA|NA|NA G Belongs to the glycosyl hydrolase 57 family OLIIENHM_02373 1123240.ATVO01000003_gene5 6.3e-18 97.8 Alphaproteobacteria Bacteria 1R6FG@1224,2U4WA@28211,COG1309@1,COG1309@2 NA|NA|NA K transcriptional regulator OLIIENHM_02374 1380386.JIAW01000001_gene4532 4.7e-124 450.7 Mycobacteriaceae Bacteria 234BS@1762,2GNUM@201174,COG1028@1,COG1028@2 NA|NA|NA IQ Belongs to the short-chain dehydrogenases reductases (SDR) family OLIIENHM_02375 1440774.Y900_004100 1.1e-178 632.9 Mycobacteriaceae Bacteria 2356B@1762,2I0E3@201174,COG1520@1,COG1520@2 NA|NA|NA S Pyrrolo-quinoline quinone OLIIENHM_02376 931627.MycrhDRAFT_1809 1.8e-66 259.2 Mycobacteriaceae Bacteria 235I9@1762,28KR0@1,2GSFZ@201174,2ZA8P@2 NA|NA|NA S Protein of unknown function (DUF3298) OLIIENHM_02377 1440774.Y900_004110 8.4e-152 543.5 Mycobacteriaceae GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0032259,GO:0034641,GO:0036260,GO:0036261,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071164,GO:0071704,GO:0090304,GO:0140098,GO:1901360 Bacteria 2334Y@1762,2I46J@201174,COG2263@1,COG2263@2 NA|NA|NA J DNA repair OLIIENHM_02378 1440774.Y900_004115 8.3e-171 606.3 Mycobacteriaceae Bacteria 234KM@1762,2HNEY@201174,COG0500@1,COG2226@2 NA|NA|NA Q methyltransferase OLIIENHM_02379 931627.MycrhDRAFT_1806 9.1e-90 336.7 Mycobacteriaceae echA17 GO:0003674,GO:0003824,GO:0004300,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 Bacteria 232SP@1762,2GJW5@201174,COG1024@1,COG1024@2 NA|NA|NA I Enoyl-CoA hydratase OLIIENHM_02380 1440774.Y900_004125 2e-112 412.1 Mycobacteriaceae MA20_36340 Bacteria 232VR@1762,2GN6D@201174,COG0494@1,COG0494@2 NA|NA|NA L Nudix hydrolase OLIIENHM_02381 1440774.Y900_004130 3.5e-133 481.1 Mycobacteriaceae modF GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 3.6.3.21,3.6.3.34 ko:K02013,ko:K02028,ko:K05776 ko02010,map02010 M00189,M00236,M00240 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14,3.A.1.3 Bacteria 235YF@1762,2GIXX@201174,COG1119@1,COG1119@2 NA|NA|NA P ABC transporter OLIIENHM_02382 931627.MycrhDRAFT_1799 6.6e-175 620.2 Mycobacteriaceae serB GO:0003674,GO:0003824,GO:0004647,GO:0004721,GO:0004722,GO:0005488,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016597,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0031406,GO:0036094,GO:0036211,GO:0040007,GO:0042578,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564 3.1.3.3 ko:K01079 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R00582 RC00017 ko00000,ko00001,ko00002,ko01000,ko01009 iNJ661.Rv3042c Bacteria 233NI@1762,2GJDH@201174,COG0560@1,COG0560@2,COG3830@1,COG3830@2 NA|NA|NA ET phosphoserine phosphatase OLIIENHM_02383 1440774.Y900_023545 4.1e-90 337.8 Mycobacteriaceae sepF GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0022402,GO:0022607,GO:0032506,GO:0042802,GO:0044085,GO:0044464,GO:0051301,GO:0071840,GO:0071944,GO:0090529 ko:K09772 ko00000,ko03036 Bacteria 233PZ@1762,2GNVH@201174,COG1799@1,COG1799@2 NA|NA|NA D Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA OLIIENHM_02384 931627.MycrhDRAFT_4020 1.8e-91 342.4 Mycobacteriaceae yggS GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 ko:K06997 ko00000 Bacteria 234PP@1762,2GMRJ@201174,COG0325@1,COG0325@2 NA|NA|NA S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis OLIIENHM_02385 931627.MycrhDRAFT_4021 2.2e-96 358.6 Mycobacteriaceae yfiH GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016679,GO:0016682,GO:0030312,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0046983,GO:0055114,GO:0071944 ko:K05810 ko00000,ko01000 Bacteria 23328@1762,2GN1M@201174,COG1496@1,COG1496@2 NA|NA|NA S Belongs to the multicopper oxidase YfiH RL5 family OLIIENHM_02386 931627.MycrhDRAFT_4022 6.9e-183 646.7 Mycobacteriaceae ftsZ GO:0000166,GO:0000287,GO:0000910,GO:0000921,GO:0000935,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022402,GO:0022607,GO:0030428,GO:0031106,GO:0032153,GO:0032155,GO:0032185,GO:0032506,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0045787,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051258,GO:0051301,GO:0051726,GO:0065003,GO:0065007,GO:0070925,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:1901265,GO:1901363 ko:K03531 ko04112,map04112 ko00000,ko00001,ko02048,ko03036,ko04812 Bacteria 233UN@1762,2GJWC@201174,COG0206@1,COG0206@2 NA|NA|NA D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity OLIIENHM_02387 1440774.Y900_023525 6.1e-108 397.5 Mycobacteriaceae ftsQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944 6.3.2.4 ko:K01921,ko:K03589,ko:K06438 ko00473,ko00550,ko01100,ko01502,ko04112,map00473,map00550,map01100,map01502,map04112 R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011,ko03036 Bacteria 233TS@1762,2H4A4@201174,COG1589@1,COG1589@2 NA|NA|NA D cell division protein FtsQ OLIIENHM_02388 1440774.Y900_023520 3e-173 614.8 Mycobacteriaceae murC GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 Bacteria 2334S@1762,2I2E7@201174,COG0773@1,COG0773@2 NA|NA|NA M Belongs to the MurCDEF family OLIIENHM_02389 1440774.Y900_013910 2.1e-177 628.6 Mycobacteriaceae Bacteria 236QK@1762,2GJSM@201174,COG1914@1,COG1914@2 NA|NA|NA P Natural resistance-associated macrophage protein OLIIENHM_02390 710421.Mycch_1186 1.8e-53 216.5 Mycobacteriaceae Bacteria 238RA@1762,2IGMU@201174,COG2239@1,COG2239@2 NA|NA|NA P Magnesium transporter OLIIENHM_02391 1150599.MPHLEI_03983 3.4e-138 498.0 Mycobacteriaceae sadh 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 Bacteria 237XV@1762,2GKNW@201174,COG1064@1,COG1064@2 NA|NA|NA S alcohol dehydrogenase OLIIENHM_02392 929712.KI912613_gene2770 1.7e-22 113.2 Rubrobacteria Bacteria 2GJPB@201174,4CSJZ@84995,COG4292@1,COG4292@2 NA|NA|NA S Bacterial low temperature requirement A protein (LtrA) OLIIENHM_02393 929712.KI912613_gene2770 4.2e-19 101.3 Rubrobacteria Bacteria 2GJPB@201174,4CSJZ@84995,COG4292@1,COG4292@2 NA|NA|NA S Bacterial low temperature requirement A protein (LtrA) OLIIENHM_02394 450851.PHZ_c3173 1.1e-20 107.8 Bacteria Bacteria 2FAMN@1,342VG@2 NA|NA|NA OLIIENHM_02395 710685.MycrhN_3449 6.4e-11 74.7 Mycobacteriaceae Bacteria 239KT@1762,2ATKT@1,2IIX0@201174,31J52@2 NA|NA|NA OLIIENHM_02396 164757.Mjls_0855 4.2e-64 252.3 Mycobacteriaceae Bacteria 2375N@1762,2ICUA@201174,COG0846@1,COG0846@2 NA|NA|NA K SIR2-like domain OLIIENHM_02397 350054.Mflv_0665 5.4e-162 577.0 Mycobacteriaceae ko:K07497 ko00000 Bacteria 237V0@1762,2GKDY@201174,COG2801@1,COG2801@2 NA|NA|NA L Transposase OLIIENHM_02398 216594.MMAR_1456 9.6e-39 166.0 Mycobacteriaceae GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K07483 ko00000 Bacteria 23AZB@1762,2IQ8F@201174,COG2963@1,COG2963@2 NA|NA|NA L Transposition of ISMyma03 OLIIENHM_02399 1298864.AUEQ01000006_gene4911 4.8e-60 238.0 Mycobacteriaceae 3.6.1.55 ko:K03574 ko00000,ko01000,ko03400 Bacteria 23690@1762,2GNMT@201174,COG1051@1,COG1051@2 NA|NA|NA F PFAM NUDIX hydrolase OLIIENHM_02400 164757.Mjls_0849 5.8e-184 650.6 Mycobacteriaceae Bacteria 237N7@1762,2HX5X@201174,COG1397@1,COG1397@2 NA|NA|NA O ADP-ribosylation crystallin J1 OLIIENHM_02401 246196.MSMEI_1230 5.6e-71 274.2 Mycobacteriaceae Bacteria 23996@1762,2BVJ9@1,2IITD@201174,32QX8@2 NA|NA|NA S Ankyrin repeats (many copies) OLIIENHM_02408 931627.MycrhDRAFT_2137 6.3e-56 226.5 Bacteria mxaE Bacteria COG2911@1,COG2911@2,COG3391@1,COG3391@2 NA|NA|NA S protein secretion OLIIENHM_02409 1078020.KEK_14503 1.7e-19 103.6 Mycobacteriaceae Bacteria 237TY@1762,2B6V4@1,2IE7X@201174,31ZUQ@2 NA|NA|NA OLIIENHM_02410 1370121.AUWS01000044_gene1308 4.5e-138 498.4 Mycobacteriaceae 2.3.1.43 ko:K00650 ko00564,ko04979,map00564,map04979 R02114 RC00037,RC00055 ko00000,ko00001,ko01000 Bacteria 232ZE@1762,2I1Z0@201174,COG1075@1,COG1075@2 NA|NA|NA S acetyltransferases and hydrolases with the alpha beta hydrolase fold OLIIENHM_02412 262316.MAP_0859c 3.6e-68 264.6 Mycobacteriaceae Bacteria 23DYC@1762,2IRS9@201174,COG4186@1,COG4186@2 NA|NA|NA S Calcineurin-like phosphoesterase superfamily domain OLIIENHM_02413 262316.MAP_0855 3.8e-42 178.7 Bacteria ko:K04485 ko00000,ko03400 Bacteria COG1066@1,COG1066@2 NA|NA|NA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function OLIIENHM_02414 216594.MMAR_3606 1.7e-11 75.5 Mycobacteriaceae Bacteria 23BG0@1762,2EID6@1,2GW81@201174,33C4J@2 NA|NA|NA S Helix-turn-helix domain OLIIENHM_02415 710686.Mycsm_06112 2.9e-27 127.5 Actinobacteria Bacteria 2GR6P@201174,COG1396@1,COG1396@2 NA|NA|NA K Helix-turn-helix OLIIENHM_02417 1440774.Y900_027735 0.0 1689.9 Mycobacteriaceae Bacteria 234J5@1762,2GJRK@201174,COG0507@1,COG0507@2 NA|NA|NA L PFAM TrwC relaxase OLIIENHM_02418 525368.HMPREF0591_1280 2.3e-07 62.0 Mycobacteriaceae Bacteria 23AE7@1762,2BF4B@1,2IS6F@201174,328WI@2 NA|NA|NA OLIIENHM_02419 1209984.BN978_01076 1.5e-35 155.6 Mycobacteriaceae Bacteria 23971@1762,2BJYG@1,2IHNM@201174,32EB6@2 NA|NA|NA OLIIENHM_02421 1209984.BN978_01097 0.0 1903.6 Mycobacteriaceae Bacteria 23735@1762,2GMY7@201174,COG0515@1,COG0515@2 NA|NA|NA KLT Nuclease-related domain OLIIENHM_02422 1209984.BN978_01098 0.0 1803.1 Mycobacteriaceae Bacteria 238GD@1762,2GN30@201174,COG1002@1,COG1002@2 NA|NA|NA V Type II restriction enzyme, methylase subunits OLIIENHM_02423 1209984.BN978_01099 0.0 1853.2 Mycobacteriaceae Bacteria 23FIH@1762,2GMTG@201174,COG1483@1,COG1483@2 NA|NA|NA S ATPase (AAA superfamily OLIIENHM_02426 1440774.Y900_019550 3.2e-12 77.0 Mycobacteriaceae Bacteria 239WD@1762,2EGCD@1,2HHAC@201174,33A46@2 NA|NA|NA S Domain of unknown function (DUF4190) OLIIENHM_02427 931627.MycrhDRAFT_5296 1.9e-151 542.0 Mycobacteriaceae mcl1 4.1.3.24,4.1.3.25,4.1.3.34,5.4.99.63 ko:K01644,ko:K08691,ko:K14447,ko:K18292 ko00630,ko00660,ko00680,ko00720,ko01100,ko01120,ko01200,ko02020,map00630,map00660,map00680,map00720,map01100,map01120,map01200,map02020 M00346,M00373,M00376 R00237,R00362,R00473,R00934,R09292 RC00067,RC00307,RC00308,RC00311,RC00407,RC00502,RC01118,RC01205,RC02835 ko00000,ko00001,ko00002,ko01000 Bacteria 2332Y@1762,2GK5J@201174,COG2301@1,COG2301@2 NA|NA|NA G Belongs to the HpcH HpaI aldolase family OLIIENHM_02428 1440774.Y900_019535 4.5e-172 610.9 Mycobacteriaceae mgtE Bacteria 233X8@1762,2GMMK@201174,COG2239@1,COG2239@2 NA|NA|NA P CBS domain OLIIENHM_02429 931627.MycrhDRAFT_5298 2.5e-68 265.0 Mycobacteriaceae Bacteria 238KA@1762,2GJRV@201174,COG4420@1,COG4420@2 NA|NA|NA S membrane OLIIENHM_02430 931627.MycrhDRAFT_5299 2.6e-115 422.5 Mycobacteriaceae Bacteria 23544@1762,2GX49@201174,COG2951@1,COG2951@2 NA|NA|NA M Transglycosylase SLT domain OLIIENHM_02431 931627.MycrhDRAFT_5300 7.2e-182 643.3 Mycobacteriaceae mrp GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0040007,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 ko:K03593 ko00000,ko03029,ko03036 Bacteria 233VZ@1762,2GJUZ@201174,COG0489@1,COG0489@2 NA|NA|NA D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP OLIIENHM_02432 258533.BN977_01407 5.6e-46 190.3 Mycobacteriaceae tatB GO:0008150,GO:0040007 ko:K03116,ko:K03117 ko03060,ko03070,map03060,map03070 M00336 ko00000,ko00001,ko00002,ko02044 2.A.64 Bacteria 2398J@1762,2IR0U@201174,COG1826@1,COG1826@2 NA|NA|NA U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation OLIIENHM_02433 1440774.Y900_019505 6.1e-221 773.5 Mycobacteriaceae htrA GO:0000785,GO:0001101,GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005783,GO:0005789,GO:0005829,GO:0005856,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006915,GO:0006950,GO:0006974,GO:0006979,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008219,GO:0008233,GO:0008236,GO:0008630,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009893,GO:0009894,GO:0009898,GO:0009966,GO:0009967,GO:0009968,GO:0009987,GO:0010033,GO:0010467,GO:0010506,GO:0010604,GO:0010638,GO:0010646,GO:0010647,GO:0010648,GO:0010821,GO:0010822,GO:0010941,GO:0010942,GO:0010950,GO:0010952,GO:0012501,GO:0012505,GO:0016020,GO:0016021,GO:0016043,GO:0016485,GO:0016540,GO:0016787,GO:0017171,GO:0019222,GO:0019538,GO:0022607,GO:0023051,GO:0023052,GO:0023056,GO:0023057,GO:0030162,GO:0030163,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031329,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0031984,GO:0032268,GO:0032270,GO:0032526,GO:0032991,GO:0033043,GO:0033554,GO:0033993,GO:0034097,GO:0034599,GO:0034605,GO:0035456,GO:0035458,GO:0035556,GO:0035631,GO:0042175,GO:0042221,GO:0042802,GO:0042981,GO:0043065,GO:0043066,GO:0043067,GO:0043068,GO:0043069,GO:0043085,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043235,GO:0043280,GO:0043281,GO:0043933,GO:0044085,GO:0044093,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044427,GO:0044429,GO:0044432,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0045786,GO:0045862,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048585,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051082,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051259,GO:0051260,GO:0051336,GO:0051345,GO:0051604,GO:0051716,GO:0051726,GO:0052547,GO:0052548,GO:0060255,GO:0060548,GO:0065003,GO:0065007,GO:0065009,GO:0070011,GO:0070013,GO:0070206,GO:0070207,GO:0070848,GO:0070887,GO:0071229,GO:0071300,GO:0071310,GO:0071345,GO:0071363,GO:0071396,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0080134,GO:0080135,GO:0097190,GO:0097193,GO:0097194,GO:0098552,GO:0098562,GO:0098796,GO:0098797,GO:0098802,GO:0098827,GO:0140096,GO:1900407,GO:1900408,GO:1901214,GO:1901215,GO:1901564,GO:1901565,GO:1901575,GO:1901700,GO:1901701,GO:1902175,GO:1902176,GO:1902494,GO:1902531,GO:1902532,GO:1902882,GO:1902883,GO:1903146,GO:1903201,GO:1903202,GO:1905286,GO:1905368,GO:1905369,GO:1905370,GO:2000116,GO:2001056,GO:2001233,GO:2001234,GO:2001235,GO:2001236,GO:2001238,GO:2001239,GO:2001241,GO:2001242,GO:2001243,GO:2001267,GO:2001269 ko:K08372 ko02020,map02020 ko00000,ko00001,ko01000,ko01002 Bacteria 234JY@1762,2GJ96@201174,COG0265@1,COG0265@2 NA|NA|NA O serine protease OLIIENHM_02434 931627.MycrhDRAFT_5304 1.3e-42 179.1 Mycobacteriaceae cseE 2.1.1.63 ko:K00567 ko00000,ko01000,ko03400 Bacteria 23975@1762,2GRQ4@201174,COG5662@1,COG5662@2 NA|NA|NA K nucleic acid-templated transcription OLIIENHM_02435 487521.OCU_12690 5.6e-60 236.9 Mycobacteriaceae sigE GO:0000302,GO:0000988,GO:0000990,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009405,GO:0009408,GO:0009410,GO:0009605,GO:0009607,GO:0009628,GO:0009636,GO:0009889,GO:0010035,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0040007,GO:0042221,GO:0042493,GO:0042542,GO:0043207,GO:0043254,GO:0044087,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0075136,GO:0080090,GO:0090034,GO:0097159,GO:0140110,GO:1901363,GO:1901700,GO:1903506,GO:2000112,GO:2000142,GO:2001141 ko:K03088 ko00000,ko03021 Bacteria 2343I@1762,2GK4C@201174,COG1595@1,COG1595@2 NA|NA|NA K Belongs to the sigma-70 factor family. ECF subfamily OLIIENHM_02436 216594.MMAR_2984 4.1e-41 174.1 Mycobacteriaceae Bacteria 235ER@1762,2HE48@201174,COG1309@1,COG1309@2 NA|NA|NA K tetR family OLIIENHM_02437 931627.MycrhDRAFT_2824 3e-291 1007.3 Mycobacteriaceae 3.1.6.6 ko:K01133 ko00000,ko01000 Bacteria 2352H@1762,2IA3D@201174,COG3119@1,COG3119@2 NA|NA|NA P sulfatase OLIIENHM_02438 710685.MycrhN_0806 6e-47 193.7 Mycobacteriaceae Bacteria 23A7C@1762,2IMWI@201174,COG3832@1,COG3832@2 NA|NA|NA S cyclase dehydrase OLIIENHM_02439 1440774.Y900_015235 9.1e-266 922.5 Mycobacteriaceae fadD2 ko:K00666 ko00000,ko01000,ko01004 Bacteria 233AM@1762,2GKDF@201174,COG0318@1,COG0318@2 NA|NA|NA IQ Activates fatty acids by binding to coenzyme A OLIIENHM_02440 1440774.Y900_015245 0.0 1193.3 Mycobacteriaceae fadE6 Bacteria 23585@1762,2GKVN@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_02441 931627.MycrhDRAFT_2858 1.1e-184 652.9 Mycobacteriaceae Bacteria 234T9@1762,2GIS1@201174,COG2271@1,COG2271@2 NA|NA|NA G Major Facilitator Superfamily OLIIENHM_02442 931627.MycrhDRAFT_2859 6.7e-136 490.3 Mycobacteriaceae serA3 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 23363@1762,2I2IC@201174,COG1052@1,COG1052@2 NA|NA|NA CH D-isomer specific 2-hydroxyacid dehydrogenase OLIIENHM_02443 1440774.Y900_015270 1.5e-76 292.7 Mycobacteriaceae Bacteria 235X8@1762,2I8E9@201174,COG1309@1,COG1309@2 NA|NA|NA K Transcriptional regulator OLIIENHM_02444 700508.D174_03775 1.9e-116 425.6 Mycobacteriaceae Bacteria 233PR@1762,2GNTU@201174,COG3662@1,COG3662@2 NA|NA|NA S protein conserved in bacteria OLIIENHM_02445 1440774.Y900_015285 7.9e-123 446.8 Mycobacteriaceae GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 232W9@1762,2GKDZ@201174,COG3315@1,COG3315@2 NA|NA|NA Q Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity OLIIENHM_02446 931627.MycrhDRAFT_2865 8.7e-170 603.2 Mycobacteriaceae ko:K06889 ko00000 Bacteria 2331G@1762,2GVYQ@201174,COG1073@1,COG1073@2 NA|NA|NA S alpha beta OLIIENHM_02447 931627.MycrhDRAFT_2869 1.6e-45 189.5 Mycobacteriaceae 3.6.1.27 ko:K19302 ko00550,map00550 R05627 RC00002 ko00000,ko00001,ko01000,ko01011 Bacteria 238R7@1762,2HU0K@201174,COG0671@1,COG0671@2 NA|NA|NA I Membrane-associated phospholipid phosphatase OLIIENHM_02448 931627.MycrhDRAFT_2876 1.5e-34 153.7 Mycobacteriaceae GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 233Q3@1762,2BK8T@1,2I9BA@201174,32ENV@2 NA|NA|NA OLIIENHM_02449 1440774.Y900_015320 9.1e-54 218.4 Mycobacteriaceae GO:0002682,GO:0002684,GO:0008150,GO:0009605,GO:0009607,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0075136 Bacteria 235X7@1762,2A1TI@1,2IDQ1@201174,30Q2E@2 NA|NA|NA OLIIENHM_02450 931627.MycrhDRAFT_2879 8.9e-84 316.6 Mycobacteriaceae ddpX 3.4.13.22 ko:K08641 ko01502,ko02020,map01502,map02020 M00651 ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504 Bacteria 235TP@1762,2GNX8@201174,COG3786@1,COG3786@2 NA|NA|NA S protein conserved in bacteria OLIIENHM_02451 1440774.Y900_015335 3.6e-66 257.7 Mycobacteriaceae Bacteria 235E3@1762,2IN5V@201174,COG5517@1,COG5517@2 NA|NA|NA Q SnoaL-like domain OLIIENHM_02452 931627.MycrhDRAFT_2884 7.6e-185 653.3 Mycobacteriaceae Bacteria 2332X@1762,28KAT@1,2GNVW@201174,2Z9XX@2 NA|NA|NA OLIIENHM_02453 1440774.Y900_015360 1.8e-48 198.7 Mycobacteriaceae Bacteria 239KR@1762,2F93U@1,2INFK@201174,341FE@2 NA|NA|NA OLIIENHM_02455 1440774.Y900_015385 3.9e-106 391.3 Mycobacteriaceae Bacteria 23390@1762,2GJQP@201174,COG2273@1,COG2273@2 NA|NA|NA G family 16 OLIIENHM_02457 267747.PPA1515 2.6e-43 182.2 Actinobacteria lidJ ko:K03611 ko00000,ko03110 5.A.2.1 Bacteria 2IIE7@201174,COG1495@1,COG1495@2 NA|NA|NA O Disulfide bond formation protein DsbB OLIIENHM_02459 1370120.AUWR01000058_gene2445 1.7e-100 372.1 Mycobacteriaceae dcd GO:0003674,GO:0003824,GO:0004170,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006244,GO:0006253,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008829,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009166,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009223,GO:0009262,GO:0009264,GO:0009314,GO:0009394,GO:0009628,GO:0009987,GO:0015949,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0033973,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046065,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0050896,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.5.4.13 ko:K01494 ko00240,ko01100,map00240,map01100 M00053 R00568,R02325 RC00074 ko00000,ko00001,ko00002,ko01000 iPC815.YPO1525 Bacteria 235VU@1762,2GKQQ@201174,COG0717@1,COG0717@2 NA|NA|NA F Belongs to the dCTP deaminase family OLIIENHM_02462 1463920.JOGB01000021_gene2132 1e-190 673.3 Actinobacteria fadE4 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 Bacteria 2GQPU@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_02463 1223543.GP2_040_00240 3.1e-24 119.4 Gordoniaceae Bacteria 2B6V4@1,2IE7X@201174,31ZUQ@2,4GF86@85026 NA|NA|NA OLIIENHM_02464 547163.BN979_01095 5.8e-144 517.3 Mycobacteriaceae nadR Bacteria 238EN@1762,2GXG6@201174,COG3172@1,COG3172@2 NA|NA|NA H AAA domain OLIIENHM_02465 1370121.AUWS01000024_gene2457 1.6e-77 295.8 Mycobacteriaceae pnuC ko:K03811 ko00000,ko02000 4.B.1.1 Bacteria 23AY8@1762,2GMBT@201174,COG3201@1,COG3201@2 NA|NA|NA H Nicotinamide mononucleotide transporter OLIIENHM_02466 216594.MMAR_1406 6.1e-21 107.5 Mycobacteriaceae Bacteria 23E8E@1762,2BB49@1,2H9HB@201174,324KM@2 NA|NA|NA OLIIENHM_02467 1370120.AUWR01000012_gene1242 5.1e-39 166.8 Mycobacteriaceae Bacteria 23AS6@1762,2BBK3@1,2IRBT@201174,3253X@2 NA|NA|NA OLIIENHM_02468 1157943.KB892705_gene1987 1.4e-14 85.5 Mycobacteriaceae Bacteria 23AGY@1762,2AWF4@1,2IPCB@201174,31NBB@2 NA|NA|NA OLIIENHM_02469 164757.Mjls_1485 3.4e-56 224.2 Mycobacteriaceae Bacteria 23ABB@1762,2DNU1@1,2INE9@201174,32Z4S@2 NA|NA|NA S SpoIIAA-like OLIIENHM_02470 350058.Mvan_1104 1.2e-35 156.0 Mycobacteriaceae Bacteria 23BAU@1762,29P7V@1,2GV7N@201174,30A5X@2 NA|NA|NA OLIIENHM_02472 246196.MSMEI_1235 4.3e-112 411.8 Mycobacteriaceae Bacteria 237N7@1762,2HX5X@201174,COG1397@1,COG1397@2 NA|NA|NA O ADP-ribosylation crystallin J1 OLIIENHM_02474 1122933.JNIY01000003_gene186 1e-15 89.7 Actinobacteria Bacteria 2B3ZZ@1,2GXQG@201174,31WQ4@2 NA|NA|NA OLIIENHM_02476 526224.Bmur_1640 3.1e-12 77.8 Bacteria Bacteria COG4859@1,COG4859@2 NA|NA|NA S Psort location Cytoplasmic, score OLIIENHM_02477 1265310.CCBD010000070_gene238 2.3e-61 241.9 Mycobacteriaceae Bacteria 23A53@1762,2C8CM@1,2GPP7@201174,32RKV@2 NA|NA|NA S Domain of unknown function (DUF4262) OLIIENHM_02478 1121924.ATWH01000001_gene4348 6.1e-11 72.8 Actinobacteria GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0008150,GO:0040008,GO:0045926,GO:0045927,GO:0048518,GO:0048519,GO:0050789,GO:0065007,GO:0097159,GO:1901363 Bacteria 2GZCR@201174,COG0864@1,COG0864@2 NA|NA|NA K Transcriptional regulator OLIIENHM_02479 419947.MRA_2006 2e-42 178.3 Actinobacteria GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005576,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045926,GO:0045927,GO:0046483,GO:0046700,GO:0048518,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:1901361,GO:1901575 ko:K07171 ko00000,ko01000,ko02048 Bacteria 2IQQ9@201174,COG2337@1,COG2337@2 NA|NA|NA L Toxic component of a toxin-antitoxin (TA) module OLIIENHM_02480 1440774.Y900_017520 6.7e-139 500.7 Mycobacteriaceae iNJ661.Rv1200 Bacteria 232GC@1762,2GIYR@201174,COG0477@1,COG0477@2 NA|NA|NA EGP Major facilitator superfamily OLIIENHM_02481 247634.GPB2148_2038 5.4e-182 644.0 Gammaproteobacteria Bacteria 1MUQH@1224,1RPJY@1236,COG2072@1,COG2072@2 NA|NA|NA P flavoprotein involved in K transport OLIIENHM_02482 1123279.ATUS01000001_gene2685 2.5e-171 609.4 unclassified Gammaproteobacteria GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016999,GO:0017000,GO:0017144,GO:0044237,GO:0044249 2.7.9.2 ko:K01007,ko:K21787 ko00333,ko00620,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00333,map00620,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00374,M00837,M00838 R00199,R11662,R11673 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 Bacteria 1J69A@118884,1Q33X@1224,1RNSN@1236,COG0574@1,COG0574@2,COG3848@1,COG3848@2 NA|NA|NA GT Pyruvate phosphate dikinase, PEP/pyruvate binding domain OLIIENHM_02483 710687.KI912270_gene4239 0.0 1447.2 Mycobacteriaceae Bacteria 23457@1762,2GJSV@201174,COG4581@1,COG4581@2 NA|NA|NA L DEAD DEAH box helicase OLIIENHM_02484 1123319.AUBE01000017_gene4680 8.9e-28 132.5 Actinobacteria 4.2.1.2 ko:K01679,ko:K03591,ko:K03749,ko:K18491 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04550,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04550,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000,ko03000,ko03036 Bacteria 2GNX9@201174,COG3087@1,COG3087@2 NA|NA|NA D Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides OLIIENHM_02485 1078020.KEK_03111 1.7e-122 445.7 Mycobacteriaceae ephF Bacteria 23FD9@1762,2I5XH@201174,COG2267@1,COG2267@2 NA|NA|NA I Alpha beta hydrolase OLIIENHM_02486 1194972.MVAC_21443 5.8e-44 183.7 Mycobacteriaceae VPA0983 Bacteria 23ABA@1762,2DRCR@1,2IPBV@201174,33B8F@2 NA|NA|NA S Domain of unknown function (DUF4174) OLIIENHM_02487 644283.Micau_5784 8.4e-27 127.5 Bacteria Bacteria COG3757@1,COG3757@2 NA|NA|NA M lysozyme activity OLIIENHM_02488 318424.EU78_21475 5.6e-96 357.1 Mycobacteriaceae Bacteria 237CA@1762,2ASZF@1,2IGMT@201174,31IF5@2 NA|NA|NA OLIIENHM_02489 1234664.AMRO01000077_gene3432 4.5e-100 371.7 Geobacillus ybbC 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 Bacteria 1VRMG@1239,1WFX8@129337,4HA8F@91061,COG3876@1,COG3876@2 NA|NA|NA S Protein of unknown function (DUF1343) OLIIENHM_02490 1283283.ATXA01000005_gene2192 7.2e-36 156.8 Frankiales Bacteria 2IGMY@201174,4EW99@85013,COG1487@1,COG1487@2 NA|NA|NA S PIN domain OLIIENHM_02491 1370125.AUWT01000033_gene1275 2.8e-20 106.7 Mycobacteriaceae Bacteria 238DT@1762,2CCYR@1,2IAZY@201174,32RG3@2 NA|NA|NA OLIIENHM_02493 2074.JNYD01000001_gene5910 3.6e-07 62.8 Pseudonocardiales 2.1.1.197 ko:K02169 ko00780,ko01100,map00780,map01100 M00572 R09543 RC00003,RC00460 ko00000,ko00001,ko00002,ko01000 Bacteria 2I3QF@201174,4E20K@85010,COG4106@1,COG4106@2 NA|NA|NA S O-methyltransferase OLIIENHM_02494 1440774.Y900_023365 1.7e-58 232.6 Mycobacteriaceae 3.1.1.74 ko:K08095 ko00000,ko01000 Bacteria 23658@1762,2A1QU@1,2HZKA@201174,30PZC@2 NA|NA|NA M Cutinase OLIIENHM_02495 368407.Memar_2442 1.4e-14 85.9 Archaea Archaea arCOG04910@1,arCOG04910@2157 NA|NA|NA S SpoIIAA-like OLIIENHM_02496 1048339.KB913029_gene3734 0.0 1385.2 Frankiales recQ1 Bacteria 2GJ4Y@201174,4ERX5@85013,COG1061@1,COG1061@2,COG3886@1,COG3886@2 NA|NA|NA L Domain of unknown function (DUF3427) OLIIENHM_02497 1299327.I546_6816 9.8e-166 589.7 Mycobacteriaceae Bacteria 233G1@1762,2GN3K@201174,COG3177@1,COG3177@2 NA|NA|NA S Fic/DOC family OLIIENHM_02498 875328.JDM601_0628 1.7e-35 156.8 Mycobacteriaceae Bacteria 234YC@1762,2AMYC@1,2I99N@201174,31CVF@2 NA|NA|NA OLIIENHM_02499 246196.MSMEI_1230 8.6e-80 303.5 Mycobacteriaceae Bacteria 23996@1762,2BVJ9@1,2IITD@201174,32QX8@2 NA|NA|NA S Ankyrin repeats (many copies) OLIIENHM_02500 164757.Mjls_0849 1e-146 526.6 Mycobacteriaceae Bacteria 237N7@1762,2HX5X@201174,COG1397@1,COG1397@2 NA|NA|NA O ADP-ribosylation crystallin J1 OLIIENHM_02501 931627.MycrhDRAFT_4475 5.7e-45 188.0 Mycobacteriaceae Bacteria 236QH@1762,2ANP2@1,2IB9D@201174,31DNG@2 NA|NA|NA S Membrane OLIIENHM_02502 1440774.Y900_021280 5.3e-160 570.9 Mycobacteriaceae MA20_25070 ko:K06902 ko04138,map04138 ko00000,ko00001,ko02000,ko04131 2.A.1.24,9.A.15.1 Bacteria 23401@1762,2GJCW@201174,COG2270@1,COG2270@2 NA|NA|NA S Major facilitator superfamily OLIIENHM_02503 1370120.AUWR01000008_gene677 4.3e-120 437.6 Mycobacteriaceae cmrA ko:K07124 ko00000 Bacteria 2331C@1762,2GKJE@201174,COG0300@1,COG0300@2 NA|NA|NA P Dehydrogenase OLIIENHM_02504 931627.MycrhDRAFT_5853 2.4e-84 318.5 Mycobacteriaceae Bacteria 234PY@1762,2HR3N@201174,COG3000@1,COG3000@2 NA|NA|NA I Fatty acid hydroxylase OLIIENHM_02505 931627.MycrhDRAFT_5854 3.3e-95 354.8 Mycobacteriaceae mce2R GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0043207,GO:0043565,GO:0044403,GO:0044419,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0075136,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 ko:K03603,ko:K05799 ko00000,ko03000 Bacteria 236Z8@1762,2I90D@201174,COG2186@1,COG2186@2 NA|NA|NA K GntR family OLIIENHM_02506 1440774.Y900_021270 3.5e-243 847.4 Mycobacteriaceae yjgR ko:K06915 ko00000 Bacteria 236SN@1762,2GM12@201174,COG0433@1,COG0433@2 NA|NA|NA S Bacterial protein of unknown function (DUF853) OLIIENHM_02507 1440774.Y900_021265 9.4e-88 329.7 Mycobacteriaceae orn GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360 ko:K13288 ko03008,map03008 ko00000,ko00001,ko01000,ko03009,ko03019 Bacteria 23440@1762,2GJR7@201174,COG1949@1,COG1949@2 NA|NA|NA A 3'-to-5' exoribonuclease specific for small oligoribonucleotides OLIIENHM_02509 1437425.CSEC_0930 9.9e-46 191.0 Bacteria Bacteria COG1506@1,COG1506@2 NA|NA|NA E serine-type peptidase activity OLIIENHM_02510 1123511.KB905880_gene2437 1.6e-24 120.2 Bacteria Bacteria COG2324@1,COG2324@2 NA|NA|NA S Carotenoid biosynthesis protein OLIIENHM_02511 1440774.Y900_021240 3.5e-174 617.8 Mycobacteriaceae lppS GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0009273,GO:0009987,GO:0016787,GO:0017171,GO:0019538,GO:0030203,GO:0030312,GO:0042546,GO:0043170,GO:0044085,GO:0044238,GO:0044464,GO:0070008,GO:0070011,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0140096,GO:1901135,GO:1901564 Bacteria 232Z1@1762,2GJBA@201174,COG1376@1,COG1376@2 NA|NA|NA S ErfK YbiS YcfS YnhG family protein OLIIENHM_02513 1440774.Y900_021210 1.5e-19 101.7 Mycobacteriaceae Bacteria 23BC4@1762,2EUTX@1,2GRIM@201174,33N9F@2 NA|NA|NA S Protein of unknown function (DUF3618) OLIIENHM_02514 262316.MAP_2329 1.3e-73 282.3 Mycobacteriaceae bcp GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016020,GO:0016209,GO:0016491,GO:0016667,GO:0016671,GO:0016684,GO:0032843,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0070887,GO:0071944,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 ko:K03564 ko00000,ko01000 iPC815.YPO3064 Bacteria 235NM@1762,2IHZ6@201174,COG1225@1,COG1225@2 NA|NA|NA O Peroxiredoxin OLIIENHM_02515 931627.MycrhDRAFT_6079 3.8e-46 191.4 Mycobacteriaceae Bacteria 239Y8@1762,2I4F1@201174,COG3103@1,COG4991@2 NA|NA|NA T sh3 domain protein OLIIENHM_02516 1440774.Y900_021200 1.1e-210 739.2 Mycobacteriaceae argE Bacteria 236VV@1762,2GM84@201174,COG0624@1,COG0624@2 NA|NA|NA E COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases OLIIENHM_02517 931627.MycrhDRAFT_4502 1.8e-60 238.4 Mycobacteriaceae acpS GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008897,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016780,GO:0018070,GO:0018193,GO:0018209,GO:0018215,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576 2.7.8.7,3.2.1.52 ko:K00997,ko:K01207 ko00520,ko00531,ko00770,ko01100,ko01501,map00520,map00531,map00770,map01100,map01501 M00628 R00022,R01625,R05963,R07809,R07810,R10831 RC00002,RC00049 ko00000,ko00001,ko00002,ko01000 Bacteria 238KS@1762,2IQF6@201174,COG0736@1,COG0736@2 NA|NA|NA I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein OLIIENHM_02518 1440774.Y900_021180 0.0 4209.1 Mycobacteriaceae fas 2.3.1.179 ko:K09458,ko:K11533 ko00061,ko00780,ko01100,ko01212,ko04931,map00061,map00780,map01100,map01212,map04931 M00082,M00083,M00572 R01624,R01626,R04355,R04428,R04429,R04533,R04534,R04535,R04536,R04537,R04543,R04544,R04566,R04568,R04724,R04726,R04952,R04953,R04954,R04955,R04957,R04958,R04960,R04961,R04963,R04964,R04965,R04966,R04968,R04969,R07762,R07763,R07764,R07765,R10115,R10119,R10700 RC00004,RC00029,RC00039,RC00052,RC00076,RC00117,RC00831,RC01095,RC02727,RC02728,RC02729,RC02857,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 234D6@1762,2GIY4@201174,COG0304@1,COG0304@2,COG0331@1,COG0331@2,COG2030@1,COG2030@2,COG4981@1,COG4981@2 NA|NA|NA IQ synthase OLIIENHM_02519 1287116.X734_27620 2.2e-12 78.2 Phyllobacteriaceae MA20_24470 Bacteria 1MXG4@1224,28JXP@1,2TSXI@28211,2Z9N4@2,43HHP@69277 NA|NA|NA S Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family OLIIENHM_02520 1237149.C900_00788 1.3e-31 142.9 Cytophagia Bacteria 47QAB@768503,4NPF9@976,COG0251@1,COG0251@2 NA|NA|NA J translation initiation inhibitor, yjgF family OLIIENHM_02521 1173024.KI912148_gene3745 6.8e-37 161.0 Bacteria nadD 2.7.6.3,2.7.7.18 ko:K00950,ko:K00969,ko:K06950 ko00760,ko00790,ko01100,map00760,map00790,map01100 M00115,M00126,M00841 R00137,R03005,R03503 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria COG1713@1,COG1713@2 NA|NA|NA H HD superfamily hydrolase involved in NAD metabolism OLIIENHM_02522 1449069.JMLO01000028_gene4437 2.3e-48 198.4 Nocardiaceae Bacteria 2DJ5J@1,2II98@201174,32UCF@2,4G1WE@85025 NA|NA|NA OLIIENHM_02523 1440774.Y900_014055 4.8e-169 600.9 Mycobacteriaceae cyp138 GO:0003674,GO:0003824,GO:0006629,GO:0008150,GO:0008152,GO:0008202,GO:0016125,GO:0016491,GO:0044238,GO:0055114,GO:0071704,GO:1901360,GO:1901615 1.14.14.1 ko:K00493 ko00071,ko00380,ko00627,ko01120,map00071,map00380,map00627,map01120 R03629,R04121,R05259 RC00046,RC01311 ko00000,ko00001,ko01000 Bacteria 2340R@1762,2GK4Z@201174,COG2124@1,COG2124@2 NA|NA|NA Q cytochrome P450 OLIIENHM_02524 1209984.BN978_00251 2.2e-31 141.7 Mycobacteriaceae Bacteria 23A1Z@1762,2EGC2@1,2IQUS@201174,33A3V@2 NA|NA|NA S Domain of unknown function (DUF4345) OLIIENHM_02525 1440774.Y900_019055 1.1e-116 426.4 Mycobacteriaceae ephC Bacteria 232WQ@1762,2HMX1@201174,COG0596@1,COG0596@2 NA|NA|NA S Alpha beta hydrolase OLIIENHM_02526 1265310.CCBD010000072_gene341 5.1e-34 150.2 Mycobacteriaceae Bacteria 23AQD@1762,2IQK3@201174,COG4430@1,COG4430@2 NA|NA|NA S Bacteriocin-protection, YdeI or OmpD-Associated OLIIENHM_02527 931627.MycrhDRAFT_1461 2.1e-106 392.1 Mycobacteriaceae Bacteria 23EVB@1762,2GK6P@201174,COG4221@1,COG4221@2 NA|NA|NA S Fungal family of unknown function (DUF1776) OLIIENHM_02528 1206726.BAFV01000123_gene6249 1.8e-84 318.9 Nocardiaceae echA3 Bacteria 2I9VC@201174,4FWJ5@85025,COG1024@1,COG1024@2 NA|NA|NA I Enoyl-CoA hydratase/isomerase OLIIENHM_02530 419947.MRA_2623A 4.9e-11 73.6 Actinobacteria ko:K06284 ko00000,ko03000 Bacteria 2HANT@201174,COG2002@1,COG2002@2 NA|NA|NA K toxin-antitoxin pair type II binding OLIIENHM_02531 419947.MRA_2624 4.6e-22 110.9 Actinobacteria vapC Bacteria 2IIF6@201174,COG1848@1,COG1848@2 NA|NA|NA S Toxic component of a toxin-antitoxin (TA) module. An RNase OLIIENHM_02532 1166018.FAES_2391 4.7e-25 122.5 Cytophagia 3.1.1.81 ko:K13075 ko02024,map02024 R08970 RC00713 ko00000,ko00001,ko01000 Bacteria 47PJC@768503,4NJZR@976,COG0491@1,COG0491@2 NA|NA|NA S Metallo-beta-lactamase superfamily OLIIENHM_02533 557599.MKAN_00795 1.4e-35 156.0 Mycobacteriaceae Bacteria 239KJ@1762,2AU5M@1,2IJSM@201174,31JSH@2 NA|NA|NA OLIIENHM_02534 1440774.Y900_001665 2.7e-09 68.2 Mycobacteriaceae Bacteria 23BJH@1762,2BI5S@1,2GRDK@201174,32CB1@2 NA|NA|NA OLIIENHM_02535 931627.MycrhDRAFT_5873 1.5e-26 125.6 Mycobacteriaceae Bacteria 23AT4@1762,2B9EU@1,2IQV5@201174,322SQ@2 NA|NA|NA OLIIENHM_02536 1440774.Y900_025780 4.7e-170 604.0 Mycobacteriaceae 1.4.1.12,1.4.1.26 ko:K21672 ko00310,ko00330,ko00472,map00310,map00330,map00472 R02825,R04200,R04201,R04687,R04688 RC00249,RC00790 ko00000,ko00001,ko01000 Bacteria 232FQ@1762,2GKE3@201174,COG3804@1,COG3804@2 NA|NA|NA S dihydrodipicolinate reductase OLIIENHM_02537 931627.MycrhDRAFT_5875 2.9e-107 394.8 Mycobacteriaceae fabG3 1.1.1.53 ko:K00038 ko00140,ko01100,map00140,map01100 R04831,R04834,R04844,R04847 RC00139,RC01219,RC01220 ko00000,ko00001,ko01000 Bacteria 235SV@1762,2I3PD@201174,COG4221@1,COG4221@2 NA|NA|NA S Dehydrogenase OLIIENHM_02538 1440774.Y900_025790 3.5e-109 401.4 Mycobacteriaceae 2.3.1.51,3.1.3.3 ko:K15781 ko00000,ko01000 Bacteria 232VF@1762,2HZ32@201174,COG0560@1,COG0560@2 NA|NA|NA E HAD-superfamily subfamily IB hydrolase, TIGR01490 OLIIENHM_02539 1440774.Y900_025800 3e-90 338.6 Mycobacteriaceae Bacteria 233PQ@1762,2GRXH@201174,COG0697@1,COG0697@2 NA|NA|NA EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily OLIIENHM_02540 931627.MycrhDRAFT_5879 0.0 1342.4 Mycobacteriaceae csxA 3.2.1.165 ko:K15855 ko00520,ko01100,map00520,map01100 R01966 RC00049 ko00000,ko00001,ko01000 Bacteria 23622@1762,2GM69@201174,COG3250@1,COG3250@2 NA|NA|NA G Belongs to the glycosyl hydrolase 2 family OLIIENHM_02541 931627.MycrhDRAFT_5880 3.8e-90 337.8 Mycobacteriaceae gyrA GO:0005575,GO:0005622,GO:0005623,GO:0009330,GO:0032991,GO:0044424,GO:0044464 5.99.1.3 ko:K02469 ko00000,ko01000,ko03032,ko03400 Bacteria 234K8@1762,2GP6T@201174,COG0188@1,COG0188@2 NA|NA|NA L Type IIA topoisomerase (DNA gyrase topo II, topoisomerase IV), A subunit OLIIENHM_02542 1150599.MPHLEI_24826 1.7e-184 652.1 Mycobacteriaceae Bacteria 23F1S@1762,2DB8Y@1,2GNYD@201174,2Z7TF@2 NA|NA|NA S Uncharacterized protein conserved in bacteria (DUF2236) OLIIENHM_02543 1380386.JIAW01000005_gene1539 1.4e-173 615.9 Mycobacteriaceae cinA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.5.1.42 ko:K03742 ko00760,map00760 R02322 RC00100 ko00000,ko00001,ko01000 Bacteria 232Q5@1762,2IQ8T@201174,COG1058@1,COG1058@2,COG1546@1,COG1546@2 NA|NA|NA S Belongs to the CinA family OLIIENHM_02544 1194972.MVAC_13843 2.3e-97 362.1 Mycobacteriaceae ddpX 3.4.13.22 ko:K08641 ko01502,ko02020,map01502,map02020 M00651 ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504 Bacteria 2329Z@1762,2GK5P@201174,COG2173@1,COG2173@2 NA|NA|NA M Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide OLIIENHM_02545 931627.MycrhDRAFT_5899 6.8e-184 649.8 Mycobacteriaceae speB 3.5.3.11 ko:K01480 ko00330,ko01100,map00330,map01100 M00133 R01157 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 Bacteria 234A3@1762,2GJA6@201174,COG0010@1,COG0010@2 NA|NA|NA E Belongs to the arginase family OLIIENHM_02546 1440774.Y900_025910 7.3e-86 324.3 Mycobacteriaceae 2.7.7.65 ko:K18967 ko00000,ko01000,ko02000 9.B.34.1.1 Bacteria 233EX@1762,2GIYH@201174,COG2199@1,COG2199@2 NA|NA|NA T Diguanylate cyclase OLIIENHM_02547 931627.MycrhDRAFT_5902 7.1e-75 287.0 Mycobacteriaceae Bacteria 23F5D@1762,2I2JZ@201174,COG2227@1,COG2227@2 NA|NA|NA H Tellurite resistance protein TehB OLIIENHM_02548 1150599.MPHLEI_12666 2.5e-98 365.2 Mycobacteriaceae yaaA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0033194,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:1901700 ko:K09861 ko00000 Bacteria 234U3@1762,2GJPM@201174,COG3022@1,COG3022@2 NA|NA|NA S Belongs to the UPF0246 family OLIIENHM_02549 258533.BN977_01876 3.1e-69 268.5 Mycobacteriaceae modA ko:K02020 ko02010,map02010 M00189 ko00000,ko00001,ko00002,ko02000 3.A.1.8 Bacteria 234BP@1762,2GMPF@201174,COG0725@1,COG0725@2 NA|NA|NA P ABC transporter, periplasmic molybdate-binding protein OLIIENHM_02550 1440774.Y900_025950 1.6e-31 142.1 Mycobacteriaceae ko:K02012 ko02010,map02010 M00190 ko00000,ko00001,ko00002,ko02000 3.A.1.10 Bacteria 23F6U@1762,2GUQY@201174,COG1840@1,COG1840@2 NA|NA|NA P ABC-type Fe3 transport system, periplasmic component OLIIENHM_02551 931627.MycrhDRAFT_5911 5.6e-42 177.2 Mycobacteriaceae Bacteria 23A2B@1762,2IP5E@201174,COG1366@1,COG1366@2 NA|NA|NA T Belongs to the anti-sigma-factor antagonist family OLIIENHM_02552 216594.MMAR_5288 4.3e-98 364.4 Mycobacteriaceae Bacteria 232ID@1762,2I8G3@201174,COG1028@1,COG1028@2 NA|NA|NA IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) OLIIENHM_02553 931627.MycrhDRAFT_4010 4.1e-183 647.5 Mycobacteriaceae Bacteria 235UZ@1762,2H3T3@201174,COG2015@1,COG2015@2 NA|NA|NA Q Metallo-beta-lactamase superfamily OLIIENHM_02554 931627.MycrhDRAFT_4009 1.7e-192 678.7 Mycobacteriaceae Bacteria 232HI@1762,2DB85@1,2GTBY@201174,2Z7Q2@2 NA|NA|NA S Sulfotransferase family OLIIENHM_02555 247156.NFA_33970 2.8e-124 451.8 Nocardiaceae Bacteria 2HVI2@201174,4FZYP@85025,COG1063@1,COG1063@2 NA|NA|NA E Alcohol dehydrogenase GroES-like domain OLIIENHM_02556 1229780.BN381_100087 5.3e-192 677.2 unclassified Actinobacteria (class) 1.4.3.4 ko:K00274 ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034 M00135 R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354 RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713 ko00000,ko00001,ko00002,ko01000 Bacteria 2GK23@201174,3UWIX@52018,COG1231@1,COG1231@2 NA|NA|NA C Flavin containing amine oxidoreductase OLIIENHM_02557 1440774.Y900_025990 1.7e-64 252.3 Mycobacteriaceae mpt53 GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0019725,GO:0042592,GO:0045454,GO:0050789,GO:0050794,GO:0055114,GO:0065007,GO:0065008 ko:K02199 ko00000,ko03110 Bacteria 238K9@1762,2IR6C@201174,COG0526@1,COG0526@2 NA|NA|NA CO Soluble secreted antigen Mpt53 OLIIENHM_02558 931627.MycrhDRAFT_5918 3.8e-95 354.8 Mycobacteriaceae Bacteria 23442@1762,2I8T6@201174,COG0785@1,COG0785@2 NA|NA|NA O PFAM Cytochrome C OLIIENHM_02559 1440774.Y900_026000 1.7e-23 115.2 Mycobacteriaceae Bacteria 23B66@1762,29G5H@1,2GQS6@201174,30339@2 NA|NA|NA OLIIENHM_02560 1370125.AUWT01000003_gene4296 3e-283 980.7 Mycobacteriaceae katG GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006282,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009605,GO:0009607,GO:0009636,GO:0009893,GO:0009987,GO:0010035,GO:0010604,GO:0016020,GO:0016209,GO:0016491,GO:0016675,GO:0016677,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0019219,GO:0019222,GO:0020012,GO:0020037,GO:0030312,GO:0030682,GO:0031323,GO:0031325,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0036094,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0043167,GO:0043168,GO:0043207,GO:0044237,GO:0044248,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045739,GO:0045935,GO:0046677,GO:0046906,GO:0048037,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051171,GO:0051173,GO:0051186,GO:0051187,GO:0051287,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052059,GO:0052173,GO:0052200,GO:0052385,GO:0052550,GO:0052564,GO:0052567,GO:0052572,GO:0055114,GO:0060255,GO:0065007,GO:0070301,GO:0070402,GO:0070404,GO:0070887,GO:0071236,GO:0071944,GO:0072593,GO:0075136,GO:0080090,GO:0080134,GO:0080135,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1901700,GO:1901701,GO:1990748,GO:2001020,GO:2001022 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 Bacteria 232CH@1762,2GJFP@201174,COG0376@1,COG0376@2 NA|NA|NA P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity OLIIENHM_02561 525368.HMPREF0591_4880 7e-61 240.7 Mycobacteriaceae Bacteria 235U5@1762,2I2PM@201174,COG1071@1,COG1071@2 NA|NA|NA C Alpha/beta hydrolase OLIIENHM_02562 1440774.Y900_026285 1.2e-114 419.5 Mycobacteriaceae Bacteria 234WF@1762,2I2DY@201174,COG4221@1,COG4221@2 NA|NA|NA S Belongs to the short-chain dehydrogenases reductases (SDR) family OLIIENHM_02564 1209984.BN978_01079 1.1e-07 62.0 Mycobacteriaceae Bacteria 2395J@1762,2AR8F@1,2IFEB@201174,31GI6@2 NA|NA|NA OLIIENHM_02565 246196.MSMEI_1232 3.7e-61 241.5 Mycobacteriaceae 3.6.1.55 ko:K03574 ko00000,ko01000,ko03400 Bacteria 23690@1762,2GNMT@201174,COG1051@1,COG1051@2 NA|NA|NA F PFAM NUDIX hydrolase OLIIENHM_02568 262316.MAP_0071 0.0 1198.3 Mycobacteriaceae dnaB GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0030312,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 ko00000,ko00001,ko01000,ko03032 Bacteria 234JE@1762,2GKXQ@201174,COG0305@1,COG0305@2 NA|NA|NA L Participates in initiation and elongation during chromosome replication OLIIENHM_02569 1408452.JAGZ01000003_gene5234 1e-189 669.5 Mycobacteriaceae yqeC 6.3.2.10,6.3.2.13 ko:K01928,ko:K15792 ko00300,ko00550,map00300,map00550 R02788,R04617 RC00064,RC00090,RC00141 ko00000,ko00001,ko01000,ko01011 Bacteria 23468@1762,2I2TV@201174,COG0769@1,COG0769@2 NA|NA|NA M UDP-N-acetylmuramyl tripeptide synthase OLIIENHM_02570 1440774.Y900_011545 6.5e-112 410.2 Mycobacteriaceae cobQ ko:K07009 ko00000 iSB619.SA_RS09800 Bacteria 232CW@1762,2GKPV@201174,COG3442@1,COG3442@2 NA|NA|NA S glutamine amidotransferase OLIIENHM_02571 258533.BN977_04066 1.6e-26 127.1 Mycobacteriaceae Bacteria 23716@1762,29ED4@1,2IDQV@201174,301B3@2 NA|NA|NA OLIIENHM_02572 931627.MycrhDRAFT_0017 2.8e-108 397.9 Mycobacteriaceae recR GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 ko:K06187 ko03440,map03440 ko00000,ko00001,ko03400 Bacteria 233DY@1762,2GJY0@201174,COG0353@1,COG0353@2 NA|NA|NA L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO OLIIENHM_02573 234621.RER_03900 2e-22 112.1 Nocardiaceae ybaB GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K09747 ko00000 Bacteria 2IRC4@201174,4G22H@85025,COG0718@1,COG0718@2 NA|NA|NA S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection OLIIENHM_02574 931627.MycrhDRAFT_0015 1.7e-105 389.0 Mycobacteriaceae GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008745,GO:0016787,GO:0016810,GO:0016811,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0061783 3.5.1.28 ko:K01448,ko:K03727 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 Bacteria 2330T@1762,2GPA9@201174,COG0860@1,COG0860@2 NA|NA|NA M N-acetylmuramoyl-L-alanine amidase OLIIENHM_02575 1209984.BN978_02677 1e-59 236.1 Mycobacteriaceae Bacteria 238TV@1762,2HJ9Q@201174,COG3832@1,COG3832@2 NA|NA|NA S polyketide cyclase OLIIENHM_02576 164757.Mjls_5275 7.1e-205 719.9 Mycobacteriaceae 1.3.1.72 ko:K09828 ko00100,ko01100,ko01110,map00100,map01100,map01110 M00101 R01457,R03689,R05703,R07488,R07493,R07498,R07499,R07507,R11096 RC00522,RC01887,RC02419 ko00000,ko00001,ko00002,ko01000 Bacteria 2338V@1762,2GKQR@201174,COG0277@1,COG0277@2 NA|NA|NA C FAD linked oxidase OLIIENHM_02577 1440774.Y900_011585 3.7e-206 724.2 Mycobacteriaceae cfa GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 2.1.1.79 ko:K00574 ko00000,ko01000 Bacteria 2343Q@1762,2GJ94@201174,COG2230@1,COG2230@2 NA|NA|NA M Cyclopropane-fatty-acyl-phospholipid synthase OLIIENHM_02578 931627.MycrhDRAFT_0009 2.5e-259 901.4 Mycobacteriaceae dnaX GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0042575,GO:0042802,GO:0043170,GO:0043846,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050790,GO:0061695,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 235J1@1762,2GJKA@201174,COG2812@1,COG2812@2 NA|NA|NA L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity OLIIENHM_02579 1440774.Y900_011600 1.1e-208 732.6 Mycobacteriaceae aspT Bacteria 23341@1762,2GKVK@201174,COG1167@1,COG1167@2 NA|NA|NA EK COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs OLIIENHM_02581 1440774.Y900_011610 1.6e-26 126.7 Mycobacteriaceae GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 Bacteria 2338J@1762,2AKY4@1,2GNRJ@201174,31BRQ@2 NA|NA|NA OLIIENHM_02582 931627.MycrhDRAFT_0004 7.4e-174 617.8 Mycobacteriaceae Bacteria 2343H@1762,2I5V8@201174,COG1506@1,COG1506@2 NA|NA|NA E peptidase S15 OLIIENHM_02583 931627.MycrhDRAFT_0003 6.2e-93 348.6 Mycobacteriaceae Bacteria 238S0@1762,2IFCE@201174,COG0657@1,COG0657@2 NA|NA|NA I acetylesterase activity OLIIENHM_02584 216594.MMAR_5265 4.4e-162 577.4 Mycobacteriaceae ligD Bacteria 235KA@1762,2GM0A@201174,COG3285@1,COG3285@2 NA|NA|NA L DNA primase OLIIENHM_02585 710685.MycrhN_2046 2.3e-150 538.5 Mycobacteriaceae ligC GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576 Bacteria 232QS@1762,2I2EA@201174,COG1793@1,COG1793@2 NA|NA|NA L DNA ligase OLIIENHM_02586 931627.MycrhDRAFT_1952 4.1e-132 477.6 Mycobacteriaceae gluQ 6.1.1.17 ko:K01885,ko:K01894 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 Bacteria 2354X@1762,2GKMT@201174,COG0008@1,COG0008@2 NA|NA|NA J Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon OLIIENHM_02587 700508.D174_00040 1.9e-204 718.4 Mycobacteriaceae lys1 Bacteria 233EG@1762,2GMQ1@201174,COG1748@1,COG1748@2 NA|NA|NA E Saccharopine dehydrogenase OLIIENHM_02588 1440774.Y900_011705 3.4e-177 627.9 Mycobacteriaceae Bacteria 233TU@1762,2GJ8V@201174,COG2124@1,COG2124@2 NA|NA|NA Q cytochrome P450 OLIIENHM_02589 216594.MMAR_3539 3.6e-68 265.0 Mycobacteriaceae rna GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0019439,GO:0030288,GO:0030313,GO:0031975,GO:0034641,GO:0034655,GO:0042597,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 3.1.27.1,3.1.27.6 ko:K01166,ko:K01169 ko00000,ko01000,ko03016 Bacteria 238XG@1762,2IHID@201174,COG3719@1,COG3719@2 NA|NA|NA J Belongs to the RNase T2 family OLIIENHM_02590 216594.MMAR_3538 2.6e-230 805.1 Mycobacteriaceae Bacteria 238DM@1762,2APN5@1,2ICDZ@201174,31ERK@2 NA|NA|NA OLIIENHM_02591 216594.MMAR_3537 3.6e-188 664.5 Mycobacteriaceae Bacteria 2374R@1762,29WPY@1,2HZKM@201174,30IAW@2 NA|NA|NA OLIIENHM_02592 931627.MycrhDRAFT_1961 1.4e-199 702.2 Mycobacteriaceae tgt 2.4.2.29 ko:K00773 R03789,R10209 RC00063 ko00000,ko01000,ko03016 Bacteria 234BK@1762,2GMWY@201174,COG0343@1,COG0343@2 NA|NA|NA J Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) OLIIENHM_02593 931627.MycrhDRAFT_1963 2.1e-40 172.2 Mycobacteriaceae ko:K14953 ko05152,map05152 ko00000,ko00001 Bacteria 238MM@1762,28UBJ@1,2IGFZ@201174,2ZGGY@2 NA|NA|NA S 19 kDa lipoprotein antigen OLIIENHM_02594 1440774.Y900_011725 4.6e-186 657.5 Mycobacteriaceae atfA1 2.3.1.20 ko:K00635 ko00561,ko01100,map00561,map01100 M00089 R02251 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 Bacteria 23298@1762,2GPHZ@201174,COG1020@1,COG1020@2 NA|NA|NA I Belongs to the long-chain O-acyltransferase family OLIIENHM_02595 1209984.BN978_06415 2.5e-09 68.9 Mycobacteriaceae Bacteria 239ZK@1762,2AVDN@1,2IMPK@201174,31M5A@2 NA|NA|NA OLIIENHM_02596 1440774.Y900_011730 1.6e-14 85.5 Mycobacteriaceae Bacteria 23BQN@1762,2B2X9@1,2GVPU@201174,31VHW@2 NA|NA|NA OLIIENHM_02597 1231057.AMGD01000011_gene1477 5.8e-57 229.6 Planococcaceae Bacteria 1TQK0@1239,26DPW@186818,4H9YF@91061,COG1948@1,COG4880@2 NA|NA|NA L Secreted protein containing C-terminal beta-propeller domain distantly related to WD-40 repeats OLIIENHM_02599 36809.MAB_0268 9e-62 243.0 Mycobacteriaceae tadA 3.5.4.1,3.5.4.33,3.8.1.5,6.3.4.19 ko:K01485,ko:K01563,ko:K04075,ko:K11991 ko00240,ko00330,ko00361,ko00625,ko01100,ko01120,map00240,map00330,map00361,map00625,map01100,map01120 R00974,R01411,R02922,R05284,R05367,R05368,R05369,R05370,R07669,R07670,R09597,R10223 RC00074,RC00477,RC00514,RC00809,RC01317,RC01340,RC01341,RC02013,RC02633,RC02634 ko00000,ko00001,ko01000,ko03016 Bacteria 238U6@1762,2IM3Z@201174,COG0590@1,COG0590@2 NA|NA|NA FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) OLIIENHM_02600 1440774.Y900_011765 1.6e-54 218.8 Mycobacteriaceae Bacteria 234N6@1762,2BM8T@1,2IG06@201174,32FSI@2 NA|NA|NA S tRNA adenosine OLIIENHM_02601 931627.MycrhDRAFT_1984 5.8e-135 487.3 Mycobacteriaceae tyrA GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009095,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019438,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.3.1.12,1.3.1.43 ko:K00210,ko:K00220,ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025,M00040 R00732,R01728 RC00125 ko00000,ko00001,ko00002,ko01000 Bacteria 232XJ@1762,2GKB4@201174,COG0287@1,COG0287@2 NA|NA|NA E prephenate dehydrogenase OLIIENHM_02602 1440774.Y900_011775 1.1e-77 296.2 Mycobacteriaceae ko:K09957 ko00000 Bacteria 233IC@1762,2GUNF@201174,COG3554@1,COG3554@2 NA|NA|NA S Putative glycolipid-binding OLIIENHM_02603 1440774.Y900_011780 1.3e-105 389.4 Mycobacteriaceae proZ ko:K05846 ko02010,map02010 M00209 ko00000,ko00001,ko00002,ko02000 3.A.1.12 Bacteria 235HV@1762,2GYTC@201174,COG1174@1,COG1174@2 NA|NA|NA P inner membrane component OLIIENHM_02604 931627.MycrhDRAFT_1987 2.6e-64 251.5 Mycobacteriaceae proW ko:K05846 ko02010,map02010 M00209 ko00000,ko00001,ko00002,ko02000 3.A.1.12 Bacteria 234Z6@1762,2GMU0@201174,COG1174@1,COG1174@2 NA|NA|NA P PFAM binding-protein-dependent transport systems inner membrane component OLIIENHM_02606 1440774.Y900_009090 0.0 1258.4 Mycobacteriaceae fadB 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 Bacteria 233C6@1762,2GJ50@201174,COG1024@1,COG1024@2,COG1250@1,COG1250@2 NA|NA|NA I 3-hydroxyacyl-CoA dehydrogenase OLIIENHM_02607 931627.MycrhDRAFT_0491 2.8e-200 704.5 Mycobacteriaceae fadA GO:0003674,GO:0003824,GO:0003988,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0030312,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 234JV@1762,2GJAC@201174,COG0183@1,COG0183@2 NA|NA|NA I Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation OLIIENHM_02609 931627.MycrhDRAFT_0489 9.7e-174 616.3 Mycobacteriaceae ybdL GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0008144,GO:0008483,GO:0010326,GO:0016740,GO:0016769,GO:0019842,GO:0030170,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0071944,GO:0097159,GO:1901363 2.6.1.17,2.6.1.88 ko:K14267,ko:K14287 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04475,R08618 RC00006,RC00025 ko00000,ko00001,ko00002,ko01000,ko01007 iNJ661.Rv0858c Bacteria 2329R@1762,2GJ7R@201174,COG0436@1,COG0436@2 NA|NA|NA E Aminotransferase OLIIENHM_02610 1370120.AUWR01000092_gene2069 6.7e-59 233.4 Mycobacteriaceae Bacteria 238WD@1762,2IGKH@201174,COG3832@1,COG3832@2 NA|NA|NA S cyclase dehydrase OLIIENHM_02611 1440774.Y900_009175 5.2e-174 617.1 Mycobacteriaceae 1.5.98.2 ko:K00320 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00567 R04464 RC01607 ko00000,ko00001,ko00002,ko01000 Bacteria 233WP@1762,2GJRF@201174,COG2141@1,COG2141@2 NA|NA|NA C F420-dependent oxidoreductase, MSMEG_2249 family OLIIENHM_02612 1150599.MPHLEI_08954 5e-61 240.7 Mycobacteriaceae 1.17.1.9 ko:K00122 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 R00519 RC02796 ko00000,ko00001,ko01000 Bacteria 233RN@1762,2GNYQ@201174,COG0243@1,COG0243@2 NA|NA|NA C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family OLIIENHM_02613 710421.Mycch_1745 4.4e-220 770.8 Mycobacteriaceae 1.17.1.9 ko:K00122 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 R00519 RC02796 ko00000,ko00001,ko01000 Bacteria 233RN@1762,2GNYQ@201174,COG0243@1,COG0243@2 NA|NA|NA C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family OLIIENHM_02614 875328.JDM601_3408 4.7e-200 703.7 Mycobacteriaceae 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 Bacteria 2336D@1762,2GIX8@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_02615 1150599.MPHLEI_09609 7e-183 646.7 Mycobacteriaceae thlA 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 232EP@1762,2GJAC@201174,COG0183@1,COG0183@2 NA|NA|NA I Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation OLIIENHM_02616 1078020.KEK_19049 7.6e-72 276.6 Mycobacteriaceae Bacteria 23414@1762,2GIX2@201174,COG1028@1,COG1028@2 NA|NA|NA IQ reductase OLIIENHM_02618 931627.MycrhDRAFT_1820 1.3e-131 475.7 Mycobacteriaceae GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 Bacteria 234EJ@1762,2GNUB@201174,COG0110@1,COG0110@2 NA|NA|NA S acetyltransferase OLIIENHM_02619 1150599.MPHLEI_05277 2e-44 184.9 Mycobacteriaceae rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 Bacteria 2350J@1762,2GJJ5@201174,COG0202@1,COG0202@2 NA|NA|NA K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates OLIIENHM_02620 1440774.Y900_007685 1.3e-67 262.7 Mycobacteriaceae rplQ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 ko:K02879 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 234G4@1762,2IHV2@201174,COG0203@1,COG0203@2 NA|NA|NA J ribosomal protein L17 OLIIENHM_02621 1440774.Y900_007680 1.4e-109 402.5 Mycobacteriaceae truA GO:0000049,GO:0001522,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0030312,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363 5.4.99.12 ko:K06173 ko00000,ko01000,ko03016 Bacteria 233K6@1762,2GJ6C@201174,COG0101@1,COG0101@2 NA|NA|NA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs OLIIENHM_02622 525368.HMPREF0591_0978 3e-68 265.0 Mycobacteriaceae cut2 GO:0005575,GO:0005576,GO:0008150,GO:0009605,GO:0009607,GO:0020012,GO:0030682,GO:0042783,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0075136 3.1.1.74 ko:K08095 ko00000,ko01000 Bacteria 234H5@1762,2DVMQ@1,2GMIZ@201174,33WEM@2 NA|NA|NA M Catalyzes the hydrolysis of cutin, a polyester that forms the structure of plant cuticle OLIIENHM_02623 931627.MycrhDRAFT_0754 4.3e-70 271.2 Mycobacteriaceae 3.1.1.74 ko:K08095 ko00000,ko01000 Bacteria 235IA@1762,2A1QU@1,2HZKA@201174,30PZC@2 NA|NA|NA M Catalyzes the hydrolysis of cutin, a polyester that forms the structure of plant cuticle OLIIENHM_02624 931627.MycrhDRAFT_0755 1e-76 293.1 Mycobacteriaceae 3.1.1.74 ko:K08095 ko00000,ko01000 Bacteria 232C3@1762,2A1QU@1,2HZKA@201174,30PZC@2 NA|NA|NA M Catalyzes the hydrolysis of cutin, a polyester that forms the structure of plant cuticle OLIIENHM_02625 1440774.Y900_007655 1.8e-50 206.5 Mycobacteriaceae ydeD Bacteria 2331W@1762,2GKVT@201174,COG0697@1,COG0697@2 NA|NA|NA EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily OLIIENHM_02627 1380386.JIAW01000004_gene163 3.6e-69 267.7 Mycobacteriaceae nrdI GO:0000166,GO:0003674,GO:0005488,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010181,GO:0019538,GO:0032553,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564 ko:K03647 ko00000 Bacteria 235Y6@1762,2IM4D@201174,COG1780@1,COG1780@2 NA|NA|NA F Probably involved in ribonucleotide reductase function OLIIENHM_02628 1077974.GOEFS_132_00770 6.9e-32 142.9 Gordoniaceae nrdH ko:K06191 ko00000 Bacteria 2IRCP@201174,4GEUW@85026,COG0695@1,COG0695@2 NA|NA|NA O Glutaredoxin OLIIENHM_02629 1440774.Y900_004425 6.5e-122 443.7 Mycobacteriaceae Bacteria 233Z9@1762,2I45Y@201174,COG1028@1,COG1028@2 NA|NA|NA IQ Belongs to the short-chain dehydrogenases reductases (SDR) family OLIIENHM_02631 1440774.Y900_004430 2.6e-79 301.6 Mycobacteriaceae ko:K21961 ko00000,ko03000 Bacteria 234HT@1762,2GND5@201174,COG1309@1,COG1309@2 NA|NA|NA K tetR family OLIIENHM_02632 1440774.Y900_004435 1.2e-232 812.4 Mycobacteriaceae Bacteria 233PJ@1762,2GK4Z@201174,COG2124@1,COG2124@2 NA|NA|NA Q cytochrome p450 OLIIENHM_02633 1449048.JQKU01000007_gene30 5.9e-34 149.8 Mycobacteriaceae ko:K21600 ko00000,ko03000 Bacteria 23AVI@1762,2IQ7U@201174,COG1937@1,COG1937@2 NA|NA|NA S Metal-sensitive transcriptional repressor OLIIENHM_02634 350054.Mflv_0983 4.4e-107 394.4 Mycobacteriaceae ko:K07090 ko00000 Bacteria 234VT@1762,2I5VT@201174,COG0730@1,COG0730@2 NA|NA|NA S membrane transporter protein OLIIENHM_02635 164757.Mjls_5692 8.3e-73 280.0 Mycobacteriaceae ko:K07112 ko00000 Bacteria 2335A@1762,2IB6H@201174,COG0607@1,COG0607@2 NA|NA|NA P PFAM Rhodanese domain protein OLIIENHM_02636 1440774.Y900_021895 1.1e-46 192.6 Mycobacteriaceae 1.8.1.8,1.8.1.9 ko:K00384,ko:K03671,ko:K03672,ko:K05838 ko00450,ko04621,ko05418,map00450,map04621,map05418 R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000,ko03110 Bacteria 23A4A@1762,2I2FB@201174,COG3118@1,COG3118@2 NA|NA|NA O Belongs to the thioredoxin family OLIIENHM_02637 1268303.RHODMAR_4728 9.4e-11 71.6 Nocardiaceae Bacteria 2EGTM@1,2GWY1@201174,33AJR@2,4G53W@85025 NA|NA|NA OLIIENHM_02638 164757.Mjls_1786 6.2e-135 487.3 Mycobacteriaceae Bacteria 23419@1762,2GJT0@201174,COG3173@1,COG3173@2 NA|NA|NA S Aminoglycoside phosphotransferase OLIIENHM_02639 1440774.Y900_003895 1.2e-68 266.5 Mycobacteriaceae hypE ko:K04655 ko00000 Bacteria 232GN@1762,2GJ7N@201174,COG0309@1,COG0309@2 NA|NA|NA O hydrogenase expression formation protein HypE OLIIENHM_02640 1440774.Y900_003175 3.8e-72 277.7 Mycobacteriaceae sigC ko:K03088 ko00000,ko03021 Bacteria 234RZ@1762,2IHWH@201174,COG1595@1,COG1595@2 NA|NA|NA K Belongs to the sigma-70 factor family. ECF subfamily OLIIENHM_02641 710687.KI912270_gene217 2.2e-186 658.7 Mycobacteriaceae cysJ Bacteria 234XN@1762,2GMHE@201174,COG3182@1,COG3182@2 NA|NA|NA S PepSY-associated TM helix OLIIENHM_02642 1440774.Y900_023995 3e-135 488.4 Mycobacteriaceae Bacteria 235SS@1762,2GKR5@201174,COG2339@1,COG2339@2 NA|NA|NA S Protease prsW family OLIIENHM_02643 931627.MycrhDRAFT_6682 0.0 1524.2 Mycobacteriaceae polA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 Bacteria 2338A@1762,2GJY2@201174,COG0258@1,COG0258@2,COG0749@1,COG0749@2 NA|NA|NA L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity OLIIENHM_02644 710686.Mycsm_03025 3.3e-37 160.6 Mycobacteriaceae ko:K07068 ko00000 Bacteria 238SF@1762,2IFQP@201174,COG1545@1,COG1545@2 NA|NA|NA S nucleic-acid-binding protein containing a Zn-ribbon OLIIENHM_02645 419947.MRA_1637 1.9e-212 745.0 Mycobacteriaceae Bacteria 2333E@1762,2GIY0@201174,COG0183@1,COG0183@2 NA|NA|NA I lipid-transfer protein OLIIENHM_02646 1440774.Y900_010675 4e-229 800.4 Mycobacteriaceae clpC GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0008150,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0040007,GO:0042802,GO:0042803,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0071944 ko:K03696 ko01100,map01100 ko00000,ko03110 Bacteria 232CB@1762,2GJ77@201174,COG0542@1,COG0542@2 NA|NA|NA O with chaperone activity, ATP-binding subunit OLIIENHM_02647 931627.MycrhDRAFT_0177 1.9e-188 665.2 Mycobacteriaceae lpqF Bacteria 232YD@1762,2GNRZ@201174,COG2367@1,COG2367@2 NA|NA|NA V Beta-lactamase class A OLIIENHM_02648 1194972.MVAC_11737 3.2e-45 187.6 Mycobacteriaceae mhuD GO:0003674,GO:0003824,GO:0004392,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006725,GO:0006778,GO:0006787,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016020,GO:0016491,GO:0016705,GO:0019439,GO:0020037,GO:0030312,GO:0033013,GO:0033015,GO:0034641,GO:0042167,GO:0042168,GO:0042440,GO:0044237,GO:0044248,GO:0044270,GO:0044464,GO:0046149,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051186,GO:0051187,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575 1.14.99.57 ko:K21481 ko00000,ko01000 Bacteria 239WA@1762,2IM1Q@201174,COG2329@1,COG2329@2 NA|NA|NA S Antibiotic biosynthesis monooxygenase OLIIENHM_02649 1440774.Y900_010640 1.6e-108 399.1 Mycobacteriaceae Bacteria 23558@1762,2GMBV@201174,COG2267@1,COG2267@2 NA|NA|NA I Alpha beta hydrolase OLIIENHM_02650 1150599.MPHLEI_13266 7.9e-128 463.4 Mycobacteriaceae mutY GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:1901360 ko:K03575 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 23408@1762,2GJD9@201174,COG1194@1,COG1194@2 NA|NA|NA L adenine glycosylase OLIIENHM_02652 1440774.Y900_011790 8.4e-162 576.6 Mycobacteriaceae proV ko:K05847 ko02010,map02010 M00209 ko00000,ko00001,ko00002,ko02000 3.A.1.12 iNJ661.Rv3758c Bacteria 2332P@1762,2GJHI@201174,COG1125@1,COG1125@2 NA|NA|NA E ABC transporter OLIIENHM_02653 931627.MycrhDRAFT_1989 1.1e-132 479.6 Mycobacteriaceae proX ko:K05845 ko02010,map02010 M00209 ko00000,ko00001,ko00002,ko02000 3.A.1.12 Bacteria 234X3@1762,2GJWY@201174,COG1732@1,COG1732@2 NA|NA|NA M Glycine betaine OLIIENHM_02654 931627.MycrhDRAFT_1990 5e-28 130.6 Mycobacteriaceae Bacteria 23ANM@1762,2GQTQ@201174,COG5416@1,COG5416@2 NA|NA|NA S membrane OLIIENHM_02655 931627.MycrhDRAFT_1993 9.5e-72 276.6 Mycobacteriaceae gpm 5.4.2.12 ko:K15634 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 Bacteria 2350Z@1762,2GM22@201174,COG0406@1,COG0406@2 NA|NA|NA G phosphoglycerate mutase OLIIENHM_02656 1440774.Y900_011825 1.4e-115 422.5 Mycobacteriaceae Bacteria 233HB@1762,2GJU1@201174,COG1028@1,COG1028@2 NA|NA|NA IQ Dehydrogenase OLIIENHM_02657 1440774.Y900_011845 0.0 1084.7 Mycobacteriaceae Bacteria 233GX@1762,2GK38@201174,COG2015@1,COG2015@2 NA|NA|NA Q alkyl sulfatase OLIIENHM_02658 931627.MycrhDRAFT_2007 1.4e-126 459.5 Mycobacteriaceae Bacteria 235P5@1762,2GIV9@201174,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor OLIIENHM_02659 710686.Mycsm_04079 1.7e-143 515.4 Mycobacteriaceae glyQS GO:0000959,GO:0003674,GO:0003824,GO:0004081,GO:0004551,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008796,GO:0009058,GO:0009059,GO:0009117,GO:0009165,GO:0009987,GO:0010467,GO:0015959,GO:0015960,GO:0015965,GO:0015966,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016875,GO:0018130,GO:0019438,GO:0019538,GO:0019637,GO:0019752,GO:0031982,GO:0032543,GO:0034641,GO:0034645,GO:0034654,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043230,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046983,GO:0055086,GO:0070062,GO:0070127,GO:0070150,GO:0071704,GO:0071944,GO:0090304,GO:0090407,GO:0140053,GO:0140098,GO:0140101,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1903561,GO:1990742 6.1.1.14,6.1.1.20 ko:K01880,ko:K01889 ko00970,map00970 M00359,M00360 R03654,R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 Bacteria 23F6J@1762,2I4F4@201174,COG0441@1,COG0441@2 NA|NA|NA J Catalyzes the attachment of glycine to tRNA(Gly) OLIIENHM_02660 931627.MycrhDRAFT_4262 2.2e-226 792.0 Mycobacteriaceae GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 Bacteria 232CV@1762,2GMGW@201174,COG1512@1,COG1512@2 NA|NA|NA M TPM domain OLIIENHM_02661 931627.MycrhDRAFT_4261 5e-176 624.0 Mycobacteriaceae dgt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.1.5.1 ko:K01129 ko00230,map00230 R01856 RC00017 ko00000,ko00001,ko01000 Bacteria 232E5@1762,2GJ8F@201174,COG0232@1,COG0232@2 NA|NA|NA F dGTPase family. Type 2 subfamily OLIIENHM_02662 931627.MycrhDRAFT_4260 0.0 1122.1 Mycobacteriaceae dnaG GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 ko:K02316 ko03030,map03030 ko00000,ko00001,ko01000,ko03032 Bacteria 23321@1762,2GJFX@201174,COG0358@1,COG0358@2 NA|NA|NA L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication OLIIENHM_02663 1440774.Y900_022450 2.5e-20 104.8 Mycobacteriaceae Bacteria 23B9P@1762,29NGN@1,2GURC@201174,309EK@2 NA|NA|NA OLIIENHM_02664 710421.Mycch_3338 5.5e-21 106.7 Mycobacteriaceae Bacteria 23ANB@1762,2DRKZ@1,2GQXZ@201174,33C8D@2 NA|NA|NA OLIIENHM_02666 1449048.JQKU01000012_gene3665 6.5e-125 453.8 Mycobacteriaceae Bacteria 2351E@1762,2GKRQ@201174,COG0560@1,COG0560@2 NA|NA|NA E haloacid dehalogenase-like hydrolase OLIIENHM_02667 1440774.Y900_013505 4.2e-09 67.4 Mycobacteriaceae Bacteria 23DYD@1762,2B8SA@1,2H6AF@201174,32229@2 NA|NA|NA OLIIENHM_02668 1440774.Y900_022495 2.3e-294 1017.7 Mycobacteriaceae acx 1.3.3.6 ko:K00232 ko00071,ko00592,ko01040,ko01100,ko01110,ko01212,ko03320,ko04024,ko04146,map00071,map00592,map01040,map01100,map01110,map01212,map03320,map04024,map04146 M00087,M00113 R01175,R01279,R03777,R03857,R03990,R04751,R04754,R07888,R07892,R07896,R07934,R07950 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000 Bacteria 232KT@1762,2GJ4X@201174,COG1960@1,COG1960@2 NA|NA|NA I Acyl-CoA oxidase OLIIENHM_02669 1440774.Y900_022500 1.8e-82 312.4 Mycobacteriaceae Bacteria 2366U@1762,2GIZ3@201174,COG1814@1,COG1814@2 NA|NA|NA S membrane OLIIENHM_02670 1440774.Y900_022505 3e-114 418.3 Mycobacteriaceae yneE GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K08994 ko00000,ko02000 1.A.46.2 Bacteria 238IE@1762,2I939@201174,COG3781@1,COG3781@2 NA|NA|NA S Bestrophin, RFP-TM, chloride channel OLIIENHM_02671 931627.MycrhDRAFT_4231 2e-288 998.0 Mycobacteriaceae ko:K16785,ko:K16786,ko:K16787 ko02010,map02010 M00582 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 Bacteria 232RE@1762,2GJ0M@201174,COG1122@1,COG1122@2 NA|NA|NA P ABC transporter OLIIENHM_02672 1440774.Y900_022525 3.6e-98 364.8 Mycobacteriaceae GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 ko:K16783,ko:K16785,ko:K16786,ko:K16787 ko02010,map02010 M00581,M00582 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 Bacteria 232VH@1762,2I8KX@201174,COG0619@1,COG0619@2 NA|NA|NA P cobalt transport OLIIENHM_02673 1440774.Y900_025250 6.3e-74 283.9 Mycobacteriaceae apa GO:0002682,GO:0002684,GO:0005575,GO:0005576,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009607,GO:0009987,GO:0009991,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0035821,GO:0042594,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052558,GO:0052559,GO:0052564,GO:0052572,GO:0065007,GO:0071496,GO:0075136 Bacteria 23504@1762,2FEYE@1,2GN2Q@201174,346X3@2 NA|NA|NA S PFAM Fibronectin-attachment OLIIENHM_02674 216594.MMAR_2738 4.4e-38 163.7 Mycobacteriaceae Bacteria 239ZC@1762,2GSMN@201174,COG2261@1,COG2261@2 NA|NA|NA S Transglycosylase associated protein OLIIENHM_02676 1078020.KEK_20173 9.8e-148 529.6 Mycobacteriaceae adhA 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 Bacteria 23456@1762,2GNVQ@201174,COG1064@1,COG1064@2 NA|NA|NA S alcohol dehydrogenase OLIIENHM_02677 1370121.AUWS01000002_gene1043 6.1e-114 417.2 Mycobacteriaceae 5.4.99.28,5.4.99.29 ko:K06177,ko:K07052 ko00000,ko01000,ko03009,ko03016 Bacteria 234FH@1762,2GKRA@201174,COG1266@1,COG1266@2 NA|NA|NA S Abortive infection protein OLIIENHM_02678 1440774.Y900_025285 0.0 1092.4 Mycobacteriaceae GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 Bacteria 236GI@1762,2GMIW@201174,COG1804@1,COG1804@2 NA|NA|NA C L-carnitine dehydratase bile acid-inducible protein F OLIIENHM_02679 1440774.Y900_025290 8.2e-215 753.1 Mycobacteriaceae 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 Bacteria 2355A@1762,2GIWZ@201174,COG1012@1,COG1012@2 NA|NA|NA C Belongs to the aldehyde dehydrogenase family OLIIENHM_02680 1440774.Y900_025300 0.0 1384.4 Mycobacteriaceae 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 Bacteria 237JD@1762,2GJ8H@201174,COG3119@1,COG3119@2 NA|NA|NA P Sulfatase OLIIENHM_02681 931627.MycrhDRAFT_5800 8.7e-228 796.2 Mycobacteriaceae 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 232HJ@1762,2I3PP@201174,COG0183@1,COG0183@2 NA|NA|NA I Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation OLIIENHM_02682 931627.MycrhDRAFT_5807 3.3e-178 630.9 Mycobacteriaceae fbpC GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0006629,GO:0006643,GO:0006664,GO:0006810,GO:0006869,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009273,GO:0009987,GO:0010876,GO:0016043,GO:0016740,GO:0016746,GO:0016747,GO:0019899,GO:0022607,GO:0030312,GO:0033036,GO:0035375,GO:0042221,GO:0042546,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0071554,GO:0071702,GO:0071704,GO:0071766,GO:0071769,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.3.1.122,2.3.1.20 ko:K18851 ko00561,ko01100,map00561,map01100 M00089 R02251 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 Bacteria 232KQ@1762,2GJX4@201174,COG0627@1,COG0627@2 NA|NA|NA S fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan, and through the synthesis of alpha,alpha-trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) to another TMM, leading to the formation of TDM OLIIENHM_02683 1380386.JIAW01000005_gene1623 9.8e-160 570.1 Mycobacteriaceae Bacteria 2346J@1762,2GZI1@201174,COG0664@1,COG0664@2,COG0668@1,COG0668@2 NA|NA|NA MT mechanosensitive OLIIENHM_02684 1380386.JIAW01000005_gene1622 6.1e-246 857.1 Mycobacteriaceae GO:0000287,GO:0003674,GO:0003824,GO:0004016,GO:0004383,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006171,GO:0006182,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0007186,GO:0007187,GO:0007188,GO:0007189,GO:0008074,GO:0008150,GO:0008152,GO:0008179,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009975,GO:0009987,GO:0010033,GO:0014070,GO:0016020,GO:0016021,GO:0016829,GO:0016849,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019899,GO:0019932,GO:0019933,GO:0019935,GO:0023052,GO:0030145,GO:0030425,GO:0031224,GO:0031226,GO:0031683,GO:0032991,GO:0033993,GO:0034641,GO:0034654,GO:0035556,GO:0035690,GO:0036477,GO:0042221,GO:0042493,GO:0042995,GO:0043005,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044444,GO:0044445,GO:0044459,GO:0044463,GO:0044464,GO:0044877,GO:0045121,GO:0046058,GO:0046068,GO:0046390,GO:0046483,GO:0046677,GO:0046872,GO:0046914,GO:0046982,GO:0046983,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052652,GO:0055086,GO:0061478,GO:0065007,GO:0070887,GO:0071236,GO:0071310,GO:0071396,GO:0071407,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097305,GO:0097306,GO:0097447,GO:0097458,GO:0098589,GO:0098805,GO:0098857,GO:0120025,GO:0120038,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901654,GO:1901655,GO:1901700,GO:1901701,GO:1904321,GO:1904322 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 Bacteria 232IH@1762,2GIVE@201174,COG2114@1,COG2114@2,COG5000@1,COG5000@2 NA|NA|NA T Guanylate cyclase OLIIENHM_02685 350058.Mvan_3060 5e-38 164.1 Mycobacteriaceae Bacteria 239PD@1762,2IM9J@201174,COG5579@1,COG5579@2 NA|NA|NA S Protein of unknown function (DUF1810) OLIIENHM_02686 1440774.Y900_025355 7e-205 719.9 Mycobacteriaceae nplT 3.2.1.1 ko:K01176 ko00500,ko01100,ko04973,map00500,map01100,map04973 R02108,R02112,R11262 ko00000,ko00001,ko01000 GH13 Bacteria 232WH@1762,2GJUT@201174,COG0366@1,COG0366@2 NA|NA|NA G Alpha amylase catalytic OLIIENHM_02687 1440774.Y900_025385 2.2e-71 275.4 Mycobacteriaceae Bacteria 234J6@1762,2GK27@201174,COG2050@1,COG2050@2 NA|NA|NA Q PFAM thioesterase superfamily OLIIENHM_02688 1298864.AUEQ01000023_gene1398 0.0 1357.8 Mycobacteriaceae atsD GO:0000323,GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0004065,GO:0004098,GO:0005488,GO:0005509,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005764,GO:0005766,GO:0005773,GO:0005775,GO:0005783,GO:0005788,GO:0006629,GO:0006643,GO:0006664,GO:0006665,GO:0006687,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0008150,GO:0008152,GO:0008484,GO:0009987,GO:0012505,GO:0016192,GO:0016787,GO:0016788,GO:0030141,GO:0031410,GO:0031974,GO:0031982,GO:0031983,GO:0032940,GO:0034774,GO:0035578,GO:0036230,GO:0042119,GO:0042582,GO:0043167,GO:0043169,GO:0043202,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043299,GO:0043312,GO:0044237,GO:0044238,GO:0044255,GO:0044422,GO:0044424,GO:0044432,GO:0044433,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0046872,GO:0046903,GO:0050896,GO:0051179,GO:0051234,GO:0060205,GO:0070013,GO:0071704,GO:0097708,GO:0099503,GO:1901135,GO:1901564,GO:1903509 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 Bacteria 233CA@1762,2GJ8H@201174,COG3119@1,COG3119@2 NA|NA|NA P thought to play an important role in the mineralization of sulfates catalytic activity a phenol sulfate H2O a phenol sulfate OLIIENHM_02689 1440774.Y900_025390 7.5e-89 333.6 Mycobacteriaceae Bacteria 233P9@1762,28KNT@1,2GNXC@201174,2ZA6Z@2 NA|NA|NA S EthD domain OLIIENHM_02690 1095772.CAHH01000011_gene760 6.6e-20 103.6 Actinobacteria Bacteria 2GPUM@201174,COG5646@1,COG5646@2 NA|NA|NA S Domain of unknown function (DU1801) OLIIENHM_02691 931627.MycrhDRAFT_5818 6.4e-110 403.7 Mycobacteriaceae echA8_6 Bacteria 234C8@1762,2GNTG@201174,COG1024@1,COG1024@2 NA|NA|NA I Enoyl-CoA hydratase OLIIENHM_02692 1440774.Y900_025410 4.5e-12 76.6 Mycobacteriaceae ko:K02192 ko00000 Bacteria 23B6K@1762,2I4ET@201174,2ZWI0@2,COG2906@1 NA|NA|NA P 2Fe-2S -binding domain OLIIENHM_02693 419947.MRA_1887 8e-74 283.1 Mycobacteriaceae bfr GO:0003674,GO:0003824,GO:0004322,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016491,GO:0016722,GO:0016724,GO:0019725,GO:0030003,GO:0033212,GO:0033214,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0071944,GO:0098771 1.16.3.1 ko:K03594 ko00860,map00860 R00078 RC02758 ko00000,ko00001,ko01000 Bacteria 233UZ@1762,2GJEI@201174,COG2193@1,COG2193@2 NA|NA|NA P Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex OLIIENHM_02694 1408813.AYMG01000004_gene4607 1.3e-08 66.6 Sphingobacteriia paiA Bacteria 1IXKP@117747,4NQVT@976,COG0454@1,COG0456@2 NA|NA|NA K Acetyltransferase (GNAT) domain OLIIENHM_02695 1299327.I546_3711 5e-71 273.9 Mycobacteriaceae Bacteria 233G8@1762,2I9B5@201174,COG2128@1,COG2128@2 NA|NA|NA S carboxymuconolactone decarboxylase OLIIENHM_02696 1440774.Y900_025430 1.4e-173 615.9 Mycobacteriaceae glnA3 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 Bacteria 23399@1762,2GJ83@201174,COG0174@1,COG0174@2 NA|NA|NA E glutamine synthetase OLIIENHM_02697 1440774.Y900_025435 1e-151 543.1 Mycobacteriaceae ko:K07045 ko00000 Bacteria 233HG@1762,2GKCJ@201174,COG2159@1,COG2159@2 NA|NA|NA S amidohydrolase OLIIENHM_02698 1440774.Y900_025550 1.1e-64 252.7 Mycobacteriaceae Bacteria 238PN@1762,2EACJ@1,2IG8C@201174,334GH@2 NA|NA|NA S Limonene-1,2-epoxide hydrolase OLIIENHM_02699 931627.MycrhDRAFT_5827 1.5e-282 978.4 Mycobacteriaceae Bacteria 234ES@1762,2GKMK@201174,COG3653@1,COG3653@2 NA|NA|NA Q N-acyl-D-aspartate D-glutamate deacylase OLIIENHM_02700 931627.MycrhDRAFT_5829 7.8e-67 260.0 Mycobacteriaceae Bacteria 239MC@1762,2IICG@201174,COG1853@1,COG1853@2 NA|NA|NA S Flavin reductase like domain OLIIENHM_02701 931627.MycrhDRAFT_5834 1.1e-184 652.9 Mycobacteriaceae cyp140 Bacteria 23373@1762,2GJ8V@201174,COG2124@1,COG2124@2 NA|NA|NA Q cytochrome p450 OLIIENHM_02702 1440774.Y900_025595 1.2e-78 299.3 Mycobacteriaceae cyp124 GO:0000166,GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0006066,GO:0006082,GO:0006629,GO:0006631,GO:0006706,GO:0006707,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008395,GO:0009056,GO:0009987,GO:0010430,GO:0016042,GO:0016125,GO:0016127,GO:0016491,GO:0016705,GO:0016709,GO:0019395,GO:0019752,GO:0020037,GO:0030258,GO:0031073,GO:0032787,GO:0034440,GO:0036094,GO:0036199,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044282,GO:0046164,GO:0046906,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0070402,GO:0071704,GO:0097089,GO:0097159,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1901615,GO:1901616,GO:1902652 1.14.15.14 ko:K20497 ko00000,ko00199,ko01000 Bacteria 232KS@1762,2GKCG@201174,COG2124@1,COG2124@2 NA|NA|NA Q cytochrome p450 OLIIENHM_02705 1078020.KEK_00015 3e-31 141.7 Mycobacteriaceae cfp2 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 Bacteria 23EZF@1762,2AP6Z@1,2IHF9@201174,30PBH@2 NA|NA|NA OLIIENHM_02706 1440774.Y900_000215 3.8e-41 174.9 Mycobacteriaceae lppK Bacteria 23ARW@1762,2A0RD@1,2ISKQ@201174,30NVW@2 NA|NA|NA OLIIENHM_02707 164757.Mjls_3147 3e-39 167.5 Mycobacteriaceae ylxP ko:K09764 ko00000 Bacteria 239XC@1762,2IQW4@201174,COG1550@1,COG1550@2 NA|NA|NA S Protein of unknown function (DUF503) OLIIENHM_02708 1440774.Y900_000225 9.7e-134 483.0 Mycobacteriaceae trmI GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016426,GO:0016429,GO:0016740,GO:0016741,GO:0030488,GO:0031515,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.219,2.1.1.220 ko:K07442 ko00000,ko01000,ko03016 Bacteria 232C4@1762,2GJPD@201174,COG2519@1,COG2519@2 NA|NA|NA J Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA OLIIENHM_02709 1120797.KB908270_gene2880 6e-99 367.5 Mycobacteriaceae GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 Bacteria 2343K@1762,2GMFE@201174,COG0589@1,COG0589@2 NA|NA|NA T Universal stress protein OLIIENHM_02710 926569.ANT_03440 9.7e-98 364.0 Chloroflexi traF ko:K12057 ko00000,ko02044 3.A.7.11.1 Bacteria 2G825@200795,COG0526@1,COG0526@2,COG0785@1,COG0785@2 NA|NA|NA CO Cytochrome C biogenesis protein OLIIENHM_02711 1341646.CBMO010000070_gene1108 2.8e-71 275.0 Mycobacteriaceae Bacteria 236BZ@1762,2A3QJ@1,2IDPQ@201174,30S89@2 NA|NA|NA OLIIENHM_02712 1120797.KB908256_gene2192 7.8e-53 213.4 Mycobacteriaceae Bacteria 237SV@1762,2IEZU@201174,COG3918@1,COG3918@2 NA|NA|NA S membrane OLIIENHM_02713 1440774.Y900_023780 4.5e-136 490.7 Mycobacteriaceae hisG GO:0000105,GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003879,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016020,GO:0016053,GO:0016208,GO:0016740,GO:0016757,GO:0016763,GO:0017076,GO:0018130,GO:0019438,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0052803,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 Bacteria 233PM@1762,2GNAX@201174,COG0040@1,COG0040@2 NA|NA|NA F ATP phosphoribosyltransferase OLIIENHM_02714 44454.NF84_10770 7.5e-40 169.5 Mycobacteriaceae hisE GO:0000105,GO:0000287,GO:0003674,GO:0003824,GO:0004635,GO:0004636,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0043167,GO:0043169,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052803,GO:0071704,GO:0071944,GO:0075136,GO:0075139,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.4.19,3.6.1.31,5.3.1.16 ko:K01523,ko:K01814,ko:K11755 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035,R04037,R04640 RC00002,RC00945,RC01055 ko00000,ko00001,ko00002,ko01000 iECNA114_1301.ECNA114_0880,iECW_1372.ECW_m2186,iEKO11_1354.EKO11_1768,iSB619.SA_RS14110,iUMN146_1321.UM146_06665,iWFL_1372.ECW_m2186,iYO844.BSU34860 Bacteria 239WB@1762,2IQ4D@201174,COG0140@1,COG0140@2 NA|NA|NA E Phosphoribosyl-ATP OLIIENHM_02715 1440774.Y900_014180 7.2e-27 127.5 Mycobacteriaceae luxT Bacteria 233P3@1762,2GNW0@201174,COG1309@1,COG1309@2 NA|NA|NA K tetR family OLIIENHM_02716 1449048.JQKU01000013_gene3249 4.2e-211 740.7 Mycobacteriaceae xylE ko:K08139 ko04113,map04113 ko00000,ko00001,ko02000 2.A.1.1 Bacteria 23F9P@1762,2GJF6@201174,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily OLIIENHM_02717 1150599.MPHLEI_11579 2.5e-81 308.5 Mycobacteriaceae yniC GO:0000287,GO:0003674,GO:0003824,GO:0003850,GO:0004346,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0050084,GO:0050286,GO:0050308,GO:0050309 3.1.3.23 ko:K19270 ko00000,ko01000 Bacteria 232X6@1762,2GJNG@201174,COG0637@1,COG0637@2 NA|NA|NA S subfamily IA, variant 3 OLIIENHM_02718 710686.Mycsm_01502 1.1e-175 622.9 Mycobacteriaceae Bacteria 234RM@1762,2HAHI@201174,COG1403@1,COG1403@2 NA|NA|NA V PFAM HNH endonuclease OLIIENHM_02719 164757.Mjls_3161 9e-268 929.1 Mycobacteriaceae metH GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 iECO103_1326.ECO103_4764,iECUMN_1333.ECUMN_4545 Bacteria 2331T@1762,2GM5Q@201174,COG0646@1,COG0646@2,COG1410@1,COG1410@2 NA|NA|NA E Methionine synthase OLIIENHM_02722 931627.MycrhDRAFT_4996 1.3e-59 236.1 Mycobacteriaceae Bacteria 237BM@1762,2C0SM@1,2IBS4@201174,33UJA@2 NA|NA|NA OLIIENHM_02723 1157943.KB892706_gene4159 1e-159 570.1 Mycobacteriaceae rpfI GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0008150,GO:0008745,GO:0016787,GO:0016810,GO:0016811,GO:0030312,GO:0040007,GO:0044464,GO:0061783,GO:0071944 ko:K21471,ko:K21473 ko00000,ko01000,ko01002,ko01011 Bacteria 2359X@1762,2GKHE@201174,COG0791@1,COG0791@2,COG3883@1,COG3883@2 NA|NA|NA M NLP P60 protein OLIIENHM_02724 1440774.Y900_000720 6.3e-96 357.1 Mycobacteriaceae rpfI GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 ko:K21471,ko:K21473,ko:K21474 ko00000,ko01000,ko01002,ko01011 Bacteria 2331Q@1762,2GP5E@201174,COG0791@1,COG0791@2 NA|NA|NA M PFAM NLP P60 protein OLIIENHM_02725 1440774.Y900_000715 3.9e-180 637.5 Mycobacteriaceae moxR1 ko:K03924 ko00000,ko01000 Bacteria 232M4@1762,2GK07@201174,COG0714@1,COG0714@2 NA|NA|NA S associated with various cellular activities OLIIENHM_02726 931627.MycrhDRAFT_5000 3.7e-158 564.3 Mycobacteriaceae GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 Bacteria 232HQ@1762,2GKSJ@201174,COG1721@1,COG1721@2 NA|NA|NA S conserved protein (some members contain a von Willebrand factor type A (vWA) domain) OLIIENHM_02727 931627.MycrhDRAFT_5001 3.2e-157 561.2 Mycobacteriaceae GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K07114 ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 Bacteria 233J7@1762,2GNKP@201174,COG2304@1,COG2304@2 NA|NA|NA S von Willebrand factor, type A OLIIENHM_02728 1265310.CCBD010000031_gene1708 3.5e-116 424.5 Mycobacteriaceae Bacteria 232PA@1762,2GK6C@201174,COG1028@1,COG1028@2 NA|NA|NA IQ reductase OLIIENHM_02729 1370120.AUWR01000060_gene4105 2.3e-134 485.0 Mycobacteriaceae inhA GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0005504,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0009058,GO:0009059,GO:0009273,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030312,GO:0030497,GO:0031406,GO:0032787,GO:0033293,GO:0034645,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0070589,GO:0071554,GO:0071704,GO:0071766,GO:0071767,GO:0071768,GO:0071840,GO:0071944,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.3.1.10,1.3.1.9 ko:K00208,ko:K11611 ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212 M00083,M00572 R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 232M5@1762,2GJ65@201174,COG0623@1,COG0623@2 NA|NA|NA I Enoyl- acyl-carrier-protein reductase NADH OLIIENHM_02730 350058.Mvan_2754 5.8e-157 560.5 Mycobacteriaceae hemH GO:0003674,GO:0003824,GO:0004325,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0046148,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051540,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 Bacteria 234ZY@1762,2GJTQ@201174,COG0276@1,COG0276@2 NA|NA|NA H Catalyzes the ferrous insertion into protoporphyrin IX OLIIENHM_02731 1440774.Y900_000685 1.8e-97 362.5 Mycobacteriaceae Bacteria 23452@1762,2BK9Y@1,2GMZH@201174,32EQ4@2 NA|NA|NA OLIIENHM_02732 931627.MycrhDRAFT_5006 8.9e-56 223.0 Mycobacteriaceae nfeD ko:K07340 ko00000 Bacteria 2397Z@1762,2IHZU@201174,COG1585@1,COG1585@2 NA|NA|NA OU Membrane protein implicated in regulation of membrane protease activity OLIIENHM_02733 931627.MycrhDRAFT_5007 1.8e-146 525.8 Mycobacteriaceae qmcA GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 Bacteria 234MA@1762,2GJ1U@201174,COG0330@1,COG0330@2 NA|NA|NA O COG0330 Membrane protease subunits, stomatin prohibitin homologs OLIIENHM_02734 44454.NF84_03440 2.1e-161 575.1 Mycobacteriaceae ko:K07497 ko00000 Bacteria 237J7@1762,2GJ3V@201174,COG2801@1,COG2801@2 NA|NA|NA L COG2801 Transposase and inactivated derivatives OLIIENHM_02736 931627.MycrhDRAFT_6757 9.4e-22 109.8 Mycobacteriaceae Bacteria 23A7Q@1762,2APGR@1,2INRE@201174,31PPW@2 NA|NA|NA S Haemophore, haem-binding OLIIENHM_02737 931627.MycrhDRAFT_5009 1.5e-85 322.8 Mycobacteriaceae ydjZ Bacteria 233RZ@1762,2GN68@201174,COG0398@1,COG0398@2 NA|NA|NA S SNARE associated Golgi protein OLIIENHM_02738 931627.MycrhDRAFT_5010 3.1e-238 831.2 Mycobacteriaceae mutA GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016999,GO:0017144,GO:0019541,GO:0019678,GO:0019752,GO:0030312,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046459,GO:0071704,GO:0071944 2.7.7.7,5.4.99.2,5.4.99.63 ko:K01847,ko:K03763,ko:K14447 ko00230,ko00240,ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,ko03030,ko03430,ko03440,map00230,map00240,map00280,map00630,map00640,map00720,map01100,map01120,map01200,map03030,map03430,map03440 M00260,M00373,M00376,M00741 R00375,R00376,R00377,R00378,R00833,R09292 RC00395,RC02795,RC02835 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 2367B@1762,2GNBQ@201174,COG1884@1,COG1884@2 NA|NA|NA I Methylmalonyl-CoA mutase OLIIENHM_02739 931627.MycrhDRAFT_1899 1.2e-127 462.6 Mycobacteriaceae ppk GO:0000287,GO:0001666,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0008976,GO:0009267,GO:0009405,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0015968,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019538,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036211,GO:0036293,GO:0040007,GO:0042594,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044464,GO:0046777,GO:0046872,GO:0050896,GO:0051704,GO:0051716,GO:0070482,GO:0071496,GO:0071704,GO:0071944,GO:1901564 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 2360S@1762,2GJ0B@201174,COG0855@1,COG0855@2 NA|NA|NA P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) OLIIENHM_02740 1440774.Y900_003760 1.6e-118 432.6 Mycobacteriaceae mutT 3.6.1.13,3.6.1.55,5.4.2.12 ko:K01515,ko:K03574,ko:K15634 ko00010,ko00230,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00230,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01054,R01518 RC00002,RC00536 ko00000,ko00001,ko00002,ko01000,ko03400 Bacteria 2345G@1762,2GNRV@201174,COG0406@1,COG0406@2,COG0494@1,COG0494@2 NA|NA|NA GL Belongs to the NUDIX hydrolase family OLIIENHM_02741 710686.Mycsm_02259 4e-45 188.3 Mycobacteriaceae hup GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006355,GO:0006725,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010106,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016043,GO:0019219,GO:0019222,GO:0019725,GO:0030003,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0040007,GO:0042262,GO:0042592,GO:0042594,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0046916,GO:0048518,GO:0048522,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0060255,GO:0065007,GO:0065008,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090143,GO:0090304,GO:0097100,GO:0097159,GO:0098771,GO:0140110,GO:1901360,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 ko:K03530 ko00000,ko03032,ko03036,ko03400 Bacteria 2337Y@1762,2GV0M@201174,COG0776@1,COG0776@2 NA|NA|NA L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions OLIIENHM_02742 931627.MycrhDRAFT_1896 5.2e-99 367.1 Mycobacteriaceae leuD GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016020,GO:0016053,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 iNJ661.Rv2987c Bacteria 233J1@1762,2GJ8Z@201174,COG0066@1,COG0066@2 NA|NA|NA E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate OLIIENHM_02743 350058.Mvan_2135 2.9e-252 877.5 Mycobacteriaceae leuC GO:0003674,GO:0003824,GO:0003861,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009316,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0019752,GO:0030312,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 iEcE24377_1341.EcE24377A_0075,iPC815.YPO0531 Bacteria 232ZM@1762,2GKT7@201174,COG0065@1,COG0065@2 NA|NA|NA E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate OLIIENHM_02744 1440774.Y900_003780 2e-110 405.2 Mycobacteriaceae ltbR Bacteria 232VE@1762,2GKB0@201174,COG1414@1,COG1414@2 NA|NA|NA K Transcriptional regulator OLIIENHM_02746 931627.MycrhDRAFT_3936 1.9e-106 392.1 Mycobacteriaceae prcA GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019773,GO:0019941,GO:0030163,GO:0030312,GO:0032991,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 ko:K03432 ko03050,map03050 M00342,M00343 ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 Bacteria 232EJ@1762,2GKZ1@201174,COG0638@1,COG0638@2 NA|NA|NA O Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation OLIIENHM_02747 1440774.Y900_000175 7.6e-126 456.8 Mycobacteriaceae prcB GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019774,GO:0019899,GO:0019941,GO:0030163,GO:0032991,GO:0035375,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 ko:K03433 ko03050,map03050 M00342,M00343 ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 Bacteria 232FT@1762,2GJ60@201174,COG0638@1,COG0638@2 NA|NA|NA O Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation OLIIENHM_02748 1078020.KEK_00050 9.2e-13 79.0 Mycobacteriaceae pup GO:0003674,GO:0005488,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0031386,GO:0032446,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044877,GO:0051603,GO:0070490,GO:0070628,GO:0070647,GO:0071704,GO:1901564,GO:1901565,GO:1901575 ko:K13570 ko00000,ko04121 Bacteria 23AM4@1762,2E9C2@1,2IQ5V@201174,333JS@2 NA|NA|NA O Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation OLIIENHM_02749 931627.MycrhDRAFT_3939 7.8e-277 959.1 Mycobacteriaceae dop GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.5.1.119,6.3.1.19 ko:K13571,ko:K20814 M00342 R11207 RC00090,RC00096 ko00000,ko00002,ko01000,ko03051 Bacteria 233XE@1762,2GJGI@201174,COG4122@1,COG4122@2 NA|NA|NA S proteasome accessory factor PafA2 OLIIENHM_02750 931627.MycrhDRAFT_3940 3.1e-100 372.1 Mycobacteriaceae Bacteria 235WV@1762,28ND6@1,2H5QC@201174,2ZBG0@2 NA|NA|NA OLIIENHM_02751 1370125.AUWT01000020_gene4656 4.3e-75 287.7 Mycobacteriaceae Bacteria 23536@1762,2D663@1,2I9AK@201174,32TKM@2 NA|NA|NA OLIIENHM_02753 1194972.MVAC_29518 2.8e-152 544.7 Mycobacteriaceae arc GO:0000302,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0010499,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0019941,GO:0022623,GO:0022624,GO:0030163,GO:0030312,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042802,GO:0043170,GO:0043335,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044877,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070628,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097366,GO:0140030,GO:0140035,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1902494,GO:1905368,GO:1905369 ko:K13527 ko03050,map03050 M00342 ko00000,ko00001,ko00002,ko03051 Bacteria 233JR@1762,2GMR1@201174,COG1222@1,COG1222@2 NA|NA|NA O ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis OLIIENHM_02754 1440774.Y900_001695 1.3e-164 585.9 Mycobacteriaceae secD GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 Bacteria 234JW@1762,2GJTT@201174,COG0342@1,COG0342@2 NA|NA|NA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA OLIIENHM_02755 1380386.JIAW01000004_gene20 1.9e-151 542.3 Mycobacteriaceae secF GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 ko:K03072,ko:K03074,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 Bacteria 232Q1@1762,2GJRS@201174,COG0341@1,COG0341@2 NA|NA|NA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA OLIIENHM_02756 1440774.Y900_001685 1e-240 839.3 Mycobacteriaceae GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044424,GO:0044444,GO:0044464 ko:K02035 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 233R4@1762,2GMMG@201174,COG0747@1,COG0747@2 NA|NA|NA E ABC-type dipeptide transport system, periplasmic component OLIIENHM_02757 1440774.Y900_001680 4.6e-62 244.2 Mycobacteriaceae apt GO:0003674,GO:0003824,GO:0003999,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006144,GO:0006168,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009113,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.7 ko:K00759 ko00230,ko01100,map00230,map01100 R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko04147 Bacteria 238RK@1762,2IM7C@201174,COG0503@1,COG0503@2 NA|NA|NA F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis OLIIENHM_02758 931627.MycrhDRAFT_4800 0.0 1402.1 Mycobacteriaceae relA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009259,GO:0009260,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0015969,GO:0015970,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034035,GO:0034036,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042578,GO:0042594,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044419,GO:0044464,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051704,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 Bacteria 233VC@1762,2GJYQ@201174,COG0317@1,COG0317@2 NA|NA|NA KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance OLIIENHM_02759 479431.Namu_0813 2.1e-176 625.5 Frankiales ko:K03294,ko:K03758 ko00000,ko02000 2.A.3.2 Bacteria 2GMTD@201174,4EU7V@85013,COG0531@1,COG0531@2 NA|NA|NA E PFAM amino acid permease-associated region OLIIENHM_02760 1440774.Y900_025180 2.5e-49 201.4 Mycobacteriaceae ydiI Bacteria 239I5@1762,2IKTU@201174,COG2050@1,COG2050@2 NA|NA|NA Q PFAM thioesterase superfamily OLIIENHM_02761 1440774.Y900_025215 1.1e-208 732.6 Mycobacteriaceae Bacteria 2329F@1762,2H2N3@201174,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor OLIIENHM_02762 931627.MycrhDRAFT_6757 1.1e-33 149.4 Mycobacteriaceae Bacteria 23A7Q@1762,2APGR@1,2INRE@201174,31PPW@2 NA|NA|NA S Haemophore, haem-binding OLIIENHM_02763 1440774.Y900_025225 1e-230 805.8 Mycobacteriaceae ndh 1.6.99.3 ko:K03885 ko00190,map00190 ko00000,ko00001,ko01000 Bacteria 233I8@1762,2GJFE@201174,COG1252@1,COG1252@2 NA|NA|NA C NADH dehydrogenase OLIIENHM_02764 1078020.KEK_20138 1.8e-127 462.2 Mycobacteriaceae Bacteria 232ZN@1762,2GM7W@201174,COG2141@1,COG2141@2 NA|NA|NA C Oxidoreductase OLIIENHM_02765 931627.MycrhDRAFT_6755 9.8e-51 206.8 Mycobacteriaceae Bacteria 233FC@1762,2GJJ2@201174,COG1028@1,COG1028@2 NA|NA|NA IQ Dehydrogenase OLIIENHM_02766 931627.MycrhDRAFT_6754 1.3e-103 382.9 Mycobacteriaceae modB GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 3.6.3.29 ko:K02017,ko:K02018,ko:K15496 ko02010,map02010 M00189,M00423 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.6.5,3.A.1.8 iECO103_1326.ECO103_0752 Bacteria 236EA@1762,2GJFB@201174,COG4149@1,COG4149@2 NA|NA|NA P ABC transporter OLIIENHM_02767 1440774.Y900_025245 1.6e-101 376.3 Mycobacteriaceae modC 3.6.3.29 ko:K02017 ko02010,map02010 M00189 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.8 Bacteria 2342T@1762,2I2RQ@201174,COG1118@1,COG1118@2 NA|NA|NA P Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system OLIIENHM_02768 931627.MycrhDRAFT_5370 6.1e-89 333.6 Mycobacteriaceae actP ko:K14393 ko00000,ko02000 2.A.21.7 Bacteria 2353Z@1762,2GJ56@201174,COG4147@1,COG4147@2 NA|NA|NA S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family OLIIENHM_02769 1298864.AUEQ01000008_gene2423 3.5e-09 67.0 Mycobacteriaceae Bacteria 23B6V@1762,2EGF6@1,2GQIG@201174,33A76@2 NA|NA|NA S Family of unknown function (DUF5302) OLIIENHM_02770 525368.HMPREF0591_5085 2e-63 248.4 Mycobacteriaceae GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0006766,GO:0006767,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0010181,GO:0017144,GO:0019842,GO:0030170,GO:0031406,GO:0032553,GO:0034641,GO:0036094,GO:0042802,GO:0042803,GO:0042816,GO:0043167,GO:0043168,GO:0043177,GO:0044237,GO:0044281,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0070279,GO:0070967,GO:0071704,GO:0072524,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901564 ko:K07005 ko00000 Bacteria 238JV@1762,2IFCX@201174,COG3467@1,COG3467@2 NA|NA|NA S PFAM pyridoxamine 5'-phosphate OLIIENHM_02771 931627.MycrhDRAFT_5376 7e-126 456.8 Mycobacteriaceae omt Bacteria 232TD@1762,2GP52@201174,COG3315@1,COG3315@2 NA|NA|NA Q O-Methyltransferase OLIIENHM_02772 1172186.KB911462_gene682 1.8e-36 158.7 Mycobacteriaceae Bacteria 239II@1762,2IQEW@201174,COG1725@1,COG1725@2 NA|NA|NA K transcriptional OLIIENHM_02773 1440774.Y900_019160 3.8e-120 437.6 Mycobacteriaceae cobB GO:0000726,GO:0003674,GO:0003824,GO:0003953,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006303,GO:0006464,GO:0006471,GO:0006476,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016787,GO:0016798,GO:0016799,GO:0019213,GO:0019538,GO:0030312,GO:0033554,GO:0033558,GO:0034641,GO:0034979,GO:0035601,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0070213,GO:0071214,GO:0071478,GO:0071479,GO:0071704,GO:0071944,GO:0090304,GO:0098732,GO:0104004,GO:0140096,GO:1901360,GO:1901564 ko:K12410 ko00000,ko01000 Bacteria 232VJ@1762,2GJI3@201174,COG0846@1,COG0846@2 NA|NA|NA K NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form OLIIENHM_02774 1440774.Y900_019155 5.6e-91 340.5 Mycobacteriaceae Bacteria 234GE@1762,2I464@201174,COG2227@1,COG2227@2 NA|NA|NA H Methyltransferase OLIIENHM_02775 350058.Mvan_4573 1.5e-271 942.2 Mycobacteriaceae ko:K06994,ko:K20470 ko00000,ko02000 2.A.6.5.6 Bacteria 233TR@1762,2GJ5A@201174,COG2409@1,COG2409@2 NA|NA|NA S MmpL family OLIIENHM_02776 931627.MycrhDRAFT_5380 6.6e-15 85.5 Mycobacteriaceae Bacteria 23B8C@1762,2B0TR@1,2GRUB@201174,31T69@2 NA|NA|NA OLIIENHM_02777 700508.D174_21155 1.1e-162 579.3 Mycobacteriaceae MA20_15180 1.13.12.16 ko:K00459 ko00910,map00910 R00025 RC02541,RC02759 ko00000,ko00001,ko01000 Bacteria 233UR@1762,2GKA6@201174,COG2070@1,COG2070@2 NA|NA|NA S 2-nitropropane dioxygenase OLIIENHM_02778 1299327.I546_2807 5.3e-112 410.6 Mycobacteriaceae Bacteria 234BS@1762,2GNUM@201174,COG1028@1,COG1028@2 NA|NA|NA IQ Belongs to the short-chain dehydrogenases reductases (SDR) family OLIIENHM_02779 1440774.Y900_019135 4.4e-160 570.9 Mycobacteriaceae mcr 5.1.99.4 ko:K01796 ko00120,ko01100,ko04146,map00120,map01100,map04146 M00104 R08734,R08739 RC02345 ko00000,ko00001,ko00002,ko01000 Bacteria 234U5@1762,2GKNX@201174,COG1804@1,COG1804@2 NA|NA|NA C carnitine dehydratase OLIIENHM_02780 931627.MycrhDRAFT_5384 1.3e-92 346.3 Mycobacteriaceae echA10 4.2.1.17,5.3.3.18 ko:K01692,ko:K15866 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093,R09837,R09839 RC00004,RC00326,RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115,RC02689,RC03003 ko00000,ko00001,ko00002,ko01000 Bacteria 2368S@1762,2GJDK@201174,COG1024@1,COG1024@2 NA|NA|NA I Enoyl-CoA hydratase OLIIENHM_02781 931627.MycrhDRAFT_5388 2.1e-83 315.5 Mycobacteriaceae ko:K07052 ko00000 Bacteria 235Y3@1762,2I925@201174,COG1266@1,COG1266@2 NA|NA|NA S Abortive infection protein OLIIENHM_02782 875328.JDM601_1119 3.3e-52 211.5 Mycobacteriaceae gca Bacteria 233UA@1762,2GP22@201174,COG0663@1,COG0663@2 NA|NA|NA S Bacterial transferase hexapeptide (six repeats) OLIIENHM_02783 1440774.Y900_019090 2.3e-60 239.2 Mycobacteriaceae ko:K03286 ko00000,ko02000 1.B.6 Bacteria 2357M@1762,2GJC2@201174,COG2335@1,COG2335@2 NA|NA|NA M Fasciclin OLIIENHM_02784 1120959.ATXF01000005_gene1526 2.3e-65 255.4 Microbacteriaceae mmsB 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 R05066 RC00099 ko00000,ko00001,ko01000 Bacteria 2GNB0@201174,4FKMG@85023,COG2084@1,COG2084@2 NA|NA|NA I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase OLIIENHM_02785 1120960.ATXG01000003_gene1970 3.1e-65 255.0 Microbacteriaceae Bacteria 2B1CB@1,2GSY7@201174,31TSW@2,4FQ20@85023 NA|NA|NA OLIIENHM_02786 931627.MycrhDRAFT_0340 0.0 1125.9 Mycobacteriaceae ptrB 3.4.21.83 ko:K01354 ko05142,ko05143,map05142,map05143 ko00000,ko00001,ko01000,ko01002 Bacteria 233WC@1762,2GNA9@201174,COG1770@1,COG1770@2 NA|NA|NA E Oligopeptidase OLIIENHM_02787 258533.BN977_02140 2.7e-139 501.5 Mycobacteriaceae purC GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6,6.3.4.13 ko:K01923,ko:K01945,ko:K03566 ko00230,ko01100,ko01110,ko01130,ko02026,map00230,map01100,map01110,map01130,map02026 M00048 R04144,R04591 RC00064,RC00090,RC00162,RC00166 ko00000,ko00001,ko00002,ko01000,ko03000 Bacteria 232AS@1762,2GK3H@201174,COG0152@1,COG0152@2 NA|NA|NA F Belongs to the SAICAR synthetase family OLIIENHM_02788 931627.MycrhDRAFT_0338 9.4e-83 313.2 Mycobacteriaceae Bacteria 235FF@1762,2DF72@1,2GIV4@201174,32U4U@2 NA|NA|NA OLIIENHM_02789 1122247.C731_3751 9.7e-180 636.3 Mycobacteriaceae cyp126A3 GO:0003674,GO:0003824,GO:0004497,GO:0006066,GO:0006629,GO:0006706,GO:0006707,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008395,GO:0009056,GO:0016042,GO:0016125,GO:0016127,GO:0016491,GO:0016705,GO:0016709,GO:0036199,GO:0044238,GO:0044281,GO:0044282,GO:0046164,GO:0055114,GO:0071704,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616,GO:1902652 Bacteria 232YJ@1762,2GKCG@201174,COG2124@1,COG2124@2 NA|NA|NA Q cytochrome p450 OLIIENHM_02790 1440774.Y900_009785 9.3e-227 792.7 Mycobacteriaceae purB 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 Bacteria 234ZQ@1762,2GKBR@201174,COG0015@1,COG0015@2 NA|NA|NA F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily OLIIENHM_02791 557599.MKAN_11170 1.9e-77 295.8 Mycobacteriaceae Bacteria 23507@1762,2I4EQ@201174,COG4328@1,COG4328@2 NA|NA|NA S Protein of unknown function (DUF429) OLIIENHM_02792 1440774.Y900_009805 1.8e-141 508.8 Mycobacteriaceae Bacteria 233UI@1762,2GIYQ@201174,COG1028@1,COG1028@2 NA|NA|NA IQ Dehydrogenase OLIIENHM_02793 350054.Mflv_1610 4.1e-70 271.2 Mycobacteriaceae Bacteria 235NQ@1762,2HUE7@201174,COG3226@1,COG3226@2 NA|NA|NA K tetR family OLIIENHM_02794 1440774.Y900_009815 2.9e-116 424.9 Mycobacteriaceae 3.1.1.102 ko:K21105 R11541 RC00020,RC00041 ko00000,ko01000 Bacteria 232HG@1762,2GKNS@201174,COG0627@1,COG0627@2 NA|NA|NA S esterase OLIIENHM_02795 931627.MycrhDRAFT_0323 1.4e-75 289.7 Mycobacteriaceae Bacteria 234NW@1762,2IK02@201174,COG2318@1,COG2318@2 NA|NA|NA S Mycothiol maleylpyruvate isomerase N-terminal domain OLIIENHM_02796 1440774.Y900_009825 1.9e-191 675.2 Mycobacteriaceae purD GO:0008150,GO:0040007 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 Bacteria 2332D@1762,2I2F5@201174,COG0151@1,COG0151@2 NA|NA|NA F Belongs to the GarS family OLIIENHM_02797 931627.MycrhDRAFT_0319 7.4e-27 126.7 Mycobacteriaceae Bacteria 23AM2@1762,2AE5Y@1,2IRA3@201174,313ZI@2 NA|NA|NA OLIIENHM_02798 1440774.Y900_009885 4.5e-48 197.2 Mycobacteriaceae rnhA 3.1.26.4,4.1.1.44 ko:K01607,ko:K03469 ko00362,ko01100,ko01120,ko01220,ko03030,map00362,map01100,map01120,map01220,map03030 R03470 RC00938 ko00000,ko00001,ko01000,ko03032 Bacteria 238R6@1762,2IFMB@201174,COG0599@1,COG0599@2 NA|NA|NA S decarboxylase OLIIENHM_02799 44454.NF84_03250 1.2e-112 412.9 Mycobacteriaceae 1.1.1.31,1.1.1.411,1.1.1.60 ko:K00020,ko:K00042,ko:K08319 ko00280,ko00630,ko01100,map00280,map00630,map01100 R01745,R01747,R05066 RC00099 ko00000,ko00001,ko01000 Bacteria 23646@1762,2GNI7@201174,COG2084@1,COG2084@2 NA|NA|NA I Dehydrogenase OLIIENHM_02800 1370121.AUWS01000024_gene2647 6.4e-118 430.3 Mycobacteriaceae Bacteria 23415@1762,2HP88@201174,COG1028@1,COG1028@2 NA|NA|NA IQ Dehydrogenase OLIIENHM_02801 1440774.Y900_009900 1.8e-224 785.0 Mycobacteriaceae aldA GO:0000166,GO:0003674,GO:0003824,GO:0004029,GO:0004030,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005975,GO:0006066,GO:0006067,GO:0006069,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0016999,GO:0017144,GO:0022900,GO:0031974,GO:0034308,GO:0036094,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070013,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901615 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 Bacteria 232CC@1762,2GIWZ@201174,COG1012@1,COG1012@2 NA|NA|NA C Belongs to the aldehyde dehydrogenase family OLIIENHM_02802 694430.Natoc_0439 2e-36 159.5 Halobacteria Archaea 23VFF@183963,2XX15@28890,COG0726@1,arCOG04934@2157 NA|NA|NA G 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process OLIIENHM_02803 762376.AXYL_06284 3e-34 152.5 Alcaligenaceae lpxD 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 Bacteria 1MUX6@1224,2VHJR@28216,3T1CS@506,COG1044@1,COG1044@2 NA|NA|NA I Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell OLIIENHM_02804 1440774.Y900_000540 2.5e-39 168.7 Mycobacteriaceae secD GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 Bacteria 239RM@1762,2IJ77@201174,COG0342@1,COG0342@2 NA|NA|NA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA OLIIENHM_02805 1440774.Y900_000555 1.2e-110 406.4 Mycobacteriaceae rarD ko:K05786 ko00000,ko02000 2.A.7.7 Bacteria 235M4@1762,2GKCP@201174,COG2962@1,COG2962@2 NA|NA|NA S TIGRFAM RarD protein OLIIENHM_02806 931627.MycrhDRAFT_5032 1.2e-113 416.8 Mycobacteriaceae Bacteria 236I1@1762,2A2DJ@1,2GNEU@201174,30QQK@2 NA|NA|NA OLIIENHM_02807 1440774.Y900_000560 9.5e-156 556.2 Mycobacteriaceae rluD GO:0000027,GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022607,GO:0022613,GO:0022618,GO:0031118,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 5.4.99.23,5.4.99.28,5.4.99.29 ko:K06177,ko:K06180 ko00000,ko01000,ko03009,ko03016 iE2348C_1286.E2348C_2868,iECED1_1282.ECED1_3035,iECSF_1327.ECSF_2432 Bacteria 232SU@1762,2GIY1@201174,COG0564@1,COG0564@2 NA|NA|NA J Responsible for synthesis of pseudouridine from uracil OLIIENHM_02808 931627.MycrhDRAFT_5028 3.7e-80 304.3 Mycobacteriaceae lspA GO:0006464,GO:0006497,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009405,GO:0009987,GO:0019538,GO:0034645,GO:0036211,GO:0040007,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044419,GO:0051704,GO:0071704,GO:1901564,GO:1901566,GO:1901576 3.4.23.36 ko:K03101 ko03060,map03060 ko00000,ko00001,ko01000,ko01002 Bacteria 233CS@1762,2GKRX@201174,COG0597@1,COG0597@2 NA|NA|NA MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins OLIIENHM_02809 1440774.Y900_000570 5.1e-101 374.4 Mycobacteriaceae ansA GO:0003674,GO:0003824,GO:0004067,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006528,GO:0006530,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009066,GO:0009068,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0032787,GO:0034641,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:0072329,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 3.5.1.1 ko:K01424 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 R00485 RC00010,RC02798 ko00000,ko00001,ko01000 Bacteria 234W7@1762,2HUB2@201174,COG0252@1,COG0252@2 NA|NA|NA EJ Asparaginase OLIIENHM_02810 1440774.Y900_000575 3.4e-197 694.5 Mycobacteriaceae dinB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.7.7.7 ko:K02346 ko00000,ko01000,ko03400 Bacteria 23394@1762,2GKBI@201174,COG0389@1,COG0389@2 NA|NA|NA L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII OLIIENHM_02811 1041522.MCOL_V223493 4.2e-132 477.6 Mycobacteriaceae ileS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 233C2@1762,2GK9M@201174,COG0060@1,COG0060@2 NA|NA|NA J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) OLIIENHM_02812 1370121.AUWS01000020_gene6713 0.0 1114.8 Mycobacteriaceae gyrA GO:0005575,GO:0005622,GO:0005623,GO:0009330,GO:0032991,GO:0044424,GO:0044464 5.99.1.3 ko:K02469,ko:K02621 ko00000,ko01000,ko02048,ko03032,ko03036,ko03400 Bacteria 235DG@1762,2GJ2Q@201174,COG0188@1,COG0188@2 NA|NA|NA L DNA gyrase topoisomerase IV, subunit A OLIIENHM_02815 1440774.Y900_010110 1.7e-162 579.3 Mycobacteriaceae cpsA Bacteria 234XI@1762,2GJM3@201174,COG1316@1,COG1316@2 NA|NA|NA K transcriptional OLIIENHM_02816 1194972.MVAC_21448 1.2e-68 266.2 Mycobacteriaceae ylbE Bacteria 2393Z@1762,2IGIQ@201174,COG0702@1,COG0702@2 NA|NA|NA GM NADH ubiquinone oxidoreductase OLIIENHM_02818 196162.Noca_1668 5.8e-238 830.5 Actinobacteria GO:0000041,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0006826,GO:0008150,GO:0008152,GO:0008823,GO:0015677,GO:0015682,GO:0016020,GO:0016021,GO:0016491,GO:0016722,GO:0016723,GO:0030001,GO:0031224,GO:0031226,GO:0033216,GO:0034220,GO:0034755,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0052851,GO:0055085,GO:0055114,GO:0071944,GO:0072512,GO:0097286,GO:0098655,GO:0098657,GO:0098659,GO:0098660,GO:0098662,GO:0098706,GO:0098711,GO:0098739,GO:0099587 1.2.1.80 ko:K14330 ko00000,ko01000 Bacteria 2IEVX@201174,COG5322@1,COG5322@2 NA|NA|NA S oxidoreductase activity OLIIENHM_02819 1108045.GORHZ_135_00210 1.9e-131 475.7 Gordoniaceae acrA1_1 Bacteria 2I2PV@201174,4GAW1@85026,COG3320@1,COG3320@2 NA|NA|NA M Male sterility protein OLIIENHM_02821 931627.MycrhDRAFT_2983 2.9e-45 188.7 Mycobacteriaceae Bacteria 23CGI@1762,2FK6M@1,2H37E@201174,3200A@2 NA|NA|NA S Probable lipoprotein LpqN OLIIENHM_02822 931627.MycrhDRAFT_2984 5e-08 63.9 Mycobacteriaceae Bacteria 23EIS@1762,2BSSZ@1,2HDGB@201174,32MWC@2 NA|NA|NA OLIIENHM_02823 1205680.CAKO01000006_gene3415 2.2e-28 132.9 Rhodospirillales ybaY ko:K03668,ko:K09914 ko00000 Bacteria 1N8AF@1224,2JUJ7@204441,2UGPH@28211,COG3126@1,COG3126@2,COG3187@1,COG3187@2 NA|NA|NA O Type III secretion system lipoprotein chaperone (YscW) OLIIENHM_02826 1545915.JROG01000001_gene577 1.9e-89 335.9 Sphingomonadales ko:K07052 ko00000 Bacteria 1RCTR@1224,2KE4U@204457,2VGN5@28211,COG1266@1,COG1266@2 NA|NA|NA S CAAX protease self-immunity OLIIENHM_02827 1078020.KEK_01010 7.8e-40 169.9 Mycobacteriaceae Bacteria 239HM@1762,2IM3I@201174,COG5470@1,COG5470@2 NA|NA|NA S Domain of unknown function (DUF1330) OLIIENHM_02829 1440774.Y900_024485 1.3e-113 416.0 Mycobacteriaceae ko:K07090 ko00000 Bacteria 232G5@1762,2GJCC@201174,COG0730@1,COG0730@2 NA|NA|NA S membrane transporter protein OLIIENHM_02830 931627.MycrhDRAFT_6057 8.5e-109 399.8 Mycobacteriaceae Bacteria 235BZ@1762,2GM9M@201174,COG0778@1,COG0778@2 NA|NA|NA C nitroreductase OLIIENHM_02831 262316.MAP_2880 2.8e-156 558.5 Mycobacteriaceae Bacteria 232NV@1762,2GU7G@201174,COG1403@1,COG1403@2 NA|NA|NA V Domain of unknown function (DUF222) OLIIENHM_02832 1440774.Y900_024465 2.4e-235 821.2 Mycobacteriaceae der GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 1.1.1.399,1.1.1.95 ko:K00058,ko:K03977 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko03009,ko04147 Bacteria 232RA@1762,2GJ8J@201174,COG1160@1,COG1160@2 NA|NA|NA S GTPase that plays an essential role in the late steps of ribosome biogenesis OLIIENHM_02833 931627.MycrhDRAFT_6054 6.8e-72 276.9 Mycobacteriaceae cmk GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0040007,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 ko:K00945 ko00240,ko01100,map00240,map01100 M00052 R00158,R00512,R01665 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 235IQ@1762,2H3SI@201174,COG0283@1,COG0283@2 NA|NA|NA F Belongs to the cytidylate kinase family. Type 1 subfamily OLIIENHM_02834 1440774.Y900_024455 7.3e-122 443.4 Mycobacteriaceae rluB GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.19,5.4.99.22 ko:K06178,ko:K06183 ko00000,ko01000,ko03009 Bacteria 233BN@1762,2GJ4N@201174,COG1187@1,COG1187@2 NA|NA|NA J Belongs to the pseudouridine synthase RsuA family OLIIENHM_02835 1120797.KB908272_gene2438 3.6e-83 314.7 Mycobacteriaceae scpB ko:K06024 ko00000,ko03036 Bacteria 233SP@1762,2GISY@201174,COG1386@1,COG1386@2 NA|NA|NA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves OLIIENHM_02836 931627.MycrhDRAFT_6051 1.3e-122 446.0 Mycobacteriaceae scpA ko:K05896 ko00000,ko03036 Bacteria 23344@1762,2GN1U@201174,COG1354@1,COG1354@2 NA|NA|NA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves OLIIENHM_02837 1440774.Y900_024440 2.2e-143 515.0 Mycobacteriaceae soj GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009295,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044464,GO:0071944 ko:K03496 ko00000,ko03036,ko04812 Bacteria 232B6@1762,2GJX3@201174,COG1192@1,COG1192@2 NA|NA|NA D involved in chromosome partitioning OLIIENHM_02838 931627.MycrhDRAFT_6049 3.9e-152 544.3 Mycobacteriaceae xerD GO:0008150,GO:0040007 ko:K03733,ko:K04763 ko00000,ko03036 Bacteria 232ND@1762,2GNDP@201174,COG4974@1,COG4974@2 NA|NA|NA D Tyrosine recombinase XerD OLIIENHM_02839 931627.MycrhDRAFT_6048 8e-74 283.5 Mycobacteriaceae nudF 3.6.1.13 ko:K01515 ko00230,map00230 R01054 RC00002 ko00000,ko00001,ko01000 Bacteria 2347F@1762,2GNW6@201174,COG0494@1,COG0494@2 NA|NA|NA L pfam nudix OLIIENHM_02840 1440774.Y900_024425 5.5e-306 1056.2 Mycobacteriaceae pyrG GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1276,iECO103_1326.ECO103_3323,iHN637.CLJU_RS01075,iNJ661.Rv1699,iPC815.YPO3377 Bacteria 232C0@1762,2GJ13@201174,COG0504@1,COG0504@2 NA|NA|NA F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates OLIIENHM_02841 350058.Mvan_5243 1.9e-165 589.0 Mycobacteriaceae Bacteria 2378H@1762,2DC1N@1,2I9JK@201174,2ZCGR@2 NA|NA|NA OLIIENHM_02842 931627.MycrhDRAFT_6768 2.4e-127 461.8 Mycobacteriaceae Bacteria 234BJ@1762,2GM27@201174,COG0501@1,COG0501@2 NA|NA|NA M Zn-dependent protease with chaperone function OLIIENHM_02844 1440774.Y900_016420 9e-76 289.7 Mycobacteriaceae groL GO:0001666,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0006458,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016020,GO:0016465,GO:0022610,GO:0030112,GO:0030312,GO:0030313,GO:0031975,GO:0032991,GO:0036293,GO:0040007,GO:0042026,GO:0042603,GO:0043388,GO:0044093,GO:0044183,GO:0044403,GO:0044406,GO:0044419,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0050896,GO:0051082,GO:0051098,GO:0051099,GO:0051101,GO:0051704,GO:0061077,GO:0065007,GO:0065009,GO:0070482,GO:0071944,GO:0101031,GO:1990220,GO:2000677,GO:2000679 ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 Bacteria 2331Z@1762,2GKC9@201174,COG0459@1,COG0459@2 NA|NA|NA O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions OLIIENHM_02845 1440774.Y900_016425 1.9e-121 442.2 Mycobacteriaceae Bacteria 233FA@1762,2GNZQ@201174,COG2852@1,COG2852@2 NA|NA|NA S Protein conserved in bacteria OLIIENHM_02846 710686.Mycsm_00497 2.3e-275 954.5 Mycobacteriaceae Bacteria 235B8@1762,2GKMK@201174,COG3653@1,COG3653@2 NA|NA|NA Q amidohydrolase OLIIENHM_02847 931627.MycrhDRAFT_3098 3.9e-74 284.3 Mycobacteriaceae Bacteria 237UY@1762,2II1I@201174,COG2318@1,COG2318@2 NA|NA|NA S Protein of unknown function (DUF664) OLIIENHM_02848 931627.MycrhDRAFT_3099 1.5e-36 159.5 Mycobacteriaceae Bacteria 239KK@1762,2AVYV@1,2INJU@201174,31MT2@2 NA|NA|NA OLIIENHM_02849 1440774.Y900_016470 1.3e-95 356.3 Mycobacteriaceae Bacteria 2365Y@1762,2EB6C@1,2GVH0@201174,33572@2 NA|NA|NA OLIIENHM_02850 1440774.Y900_016495 0.0 1119.8 Mycobacteriaceae f1pep1 3.4.21.26 ko:K01322 ko04614,map04614 ko00000,ko00001,ko01000,ko01002 Bacteria 232NX@1762,2IRXB@201174,COG1505@1,COG1505@2 NA|NA|NA E Prolyl oligopeptidase OLIIENHM_02852 350058.Mvan_3284 1.6e-105 389.4 Mycobacteriaceae mctB GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0008150,GO:0009279,GO:0015267,GO:0015288,GO:0016020,GO:0016021,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032991,GO:0044425,GO:0044462,GO:0044464,GO:0046930,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098796 Bacteria 2334W@1762,2D1T0@1,2I8E5@201174,32TBA@2 NA|NA|NA S copper ion homeostasis OLIIENHM_02853 1440774.Y900_024415 1.2e-187 662.5 Mycobacteriaceae Bacteria 233V4@1762,2GPAA@201174,COG4825@1,COG4825@2 NA|NA|NA S membrane-anchored protein OLIIENHM_02854 931627.MycrhDRAFT_6032 2.7e-95 355.1 Mycobacteriaceae recN GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0030312,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:1901360 ko:K03631,ko:K13582 ko04112,map04112 ko00000,ko00001,ko03400 Bacteria 233EE@1762,2GIVG@201174,COG0497@1,COG0497@2 NA|NA|NA L May be involved in recombinational repair of damaged DNA OLIIENHM_02856 1440774.Y900_020095 3.3e-276 957.2 Mycobacteriaceae argS GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 iAF987.Gmet_1434 Bacteria 2341V@1762,2GKQ3@201174,COG0018@1,COG0018@2 NA|NA|NA J Arginyl-tRNA synthetase OLIIENHM_02858 350058.Mvan_3315 5.7e-54 217.2 Mycobacteriaceae yhbS GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006473,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564 ko:K03824 ko00000,ko01000 Bacteria 23C56@1762,2IKX0@201174,COG3153@1,COG3153@2 NA|NA|NA S acetyltransferase OLIIENHM_02859 1440774.Y900_024280 2.1e-159 568.5 Mycobacteriaceae argC GO:0000166,GO:0003674,GO:0005488,GO:0008150,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0048037,GO:0050661,GO:0050662,GO:0070401,GO:0097159,GO:1901265,GO:1901363 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 Bacteria 232UY@1762,2GKQK@201174,COG0002@1,COG0002@2 NA|NA|NA E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde OLIIENHM_02860 547163.BN979_06450 1.6e-190 672.2 Mycobacteriaceae argJ GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35,2.7.2.8 ko:K00620,ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282,R02649 RC00002,RC00004,RC00043,RC00064 ko00000,ko00001,ko00002,ko01000 Bacteria 233WV@1762,2GIW0@201174,COG1364@1,COG1364@2 NA|NA|NA E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate OLIIENHM_02861 350058.Mvan_3312 3.2e-137 494.6 Mycobacteriaceae argB GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0030312,GO:0031406,GO:0034618,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS10565,iJN678.argB,iLJ478.TM1784 Bacteria 234RJ@1762,2GKDS@201174,COG0548@1,COG0548@2 NA|NA|NA E Belongs to the acetylglutamate kinase family. ArgB subfamily OLIIENHM_02862 1440774.Y900_024295 1.2e-179 636.0 Mycobacteriaceae argD GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0008150,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 232PW@1762,2GKE9@201174,COG4992@1,COG4992@2 NA|NA|NA E acetylornithine aminotransferase OLIIENHM_02863 1209984.BN978_06178 1.3e-144 519.2 Mycobacteriaceae argF GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0040007,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 Bacteria 234UY@1762,2GJ6H@201174,COG0078@1,COG0078@2 NA|NA|NA E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline OLIIENHM_02864 1440774.Y900_024305 1.9e-65 255.4 Mycobacteriaceae argR GO:0000820,GO:0000821,GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006259,GO:0006310,GO:0006355,GO:0006520,GO:0006521,GO:0006525,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009064,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016043,GO:0016597,GO:0019219,GO:0019222,GO:0019752,GO:0022607,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031329,GO:0031333,GO:0031334,GO:0031406,GO:0032991,GO:0032993,GO:0033238,GO:0033241,GO:0034214,GO:0034618,GO:0034641,GO:0036094,GO:0042150,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043254,GO:0043436,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044212,GO:0044237,GO:0044238,GO:0044260,GO:0044281,GO:0044424,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051130,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051259,GO:0060255,GO:0062012,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0140110,GO:1900079,GO:1900081,GO:1901360,GO:1901363,GO:1901564,GO:1901605,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2000144,GO:2000282,GO:2001141 ko:K03402 ko00000,ko03000 Bacteria 238MQ@1762,2GKA5@201174,COG1438@1,COG1438@2 NA|NA|NA K Regulates arginine biosynthesis genes OLIIENHM_02865 710686.Mycsm_03090 1.9e-217 761.5 Mycobacteriaceae argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0071944,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 iNJ661.Rv1658 Bacteria 2330Y@1762,2GK96@201174,COG0137@1,COG0137@2 NA|NA|NA E Belongs to the argininosuccinate synthase family. Type 1 subfamily OLIIENHM_02866 931627.MycrhDRAFT_6742 1.6e-223 781.9 Mycobacteriaceae argH GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0030312,GO:0040007,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 iJN678.argH Bacteria 232QE@1762,2GJ2A@201174,COG0165@1,COG0165@2 NA|NA|NA E argininosuccinate lyase OLIIENHM_02867 931627.MycrhDRAFT_6743 1.4e-158 565.8 Mycobacteriaceae yjjK ko:K15738 ko00000,ko02000 3.A.1.120.6 Bacteria 232ZH@1762,2GJ5M@201174,COG0488@1,COG0488@2 NA|NA|NA S ABC transporter OLIIENHM_02868 931627.MycrhDRAFT_3928 1.2e-97 362.8 Mycobacteriaceae helY GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575 ko:K03727 ko00000,ko01000 Bacteria 233UF@1762,2GJEX@201174,COG4581@1,COG4581@2 NA|NA|NA L dead DEAH box helicase OLIIENHM_02869 1440774.Y900_000120 7.8e-52 210.7 Mycobacteriaceae GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 Bacteria 233ZE@1762,2BYFJ@1,2I8PS@201174,33240@2 NA|NA|NA S Domain of unknown function (DUF4333) OLIIENHM_02870 864069.MicloDRAFT_00041960 9.9e-83 313.5 Methylobacteriaceae 3.8.1.3 ko:K01561 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 R05287 RC00697 ko00000,ko00001,ko01000 Bacteria 1JTBA@119045,1MUVB@1224,2TREP@28211,COG0596@1,COG0596@2 NA|NA|NA S PFAM alpha beta hydrolase fold OLIIENHM_02871 1440774.Y900_000115 1.6e-134 485.7 Mycobacteriaceae polA GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 Bacteria 235QF@1762,2GKTZ@201174,COG0258@1,COG0258@2 NA|NA|NA L 5'-3' exonuclease OLIIENHM_02872 1440774.Y900_000105 4.6e-165 587.4 Mycobacteriaceae pepE 3.4.13.9 ko:K01271,ko:K01274 ko00000,ko01000,ko01002 Bacteria 2346P@1762,2GM7D@201174,COG0006@1,COG0006@2 NA|NA|NA E Belongs to the peptidase M24B family OLIIENHM_02873 1440774.Y900_000100 1.7e-56 225.3 Mycobacteriaceae GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016627,GO:0030312,GO:0031406,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043177,GO:0044464,GO:0046983,GO:0048037,GO:0050662,GO:0055114,GO:0070967,GO:0071944,GO:0097159,GO:0097367,GO:1901363 Bacteria 238K7@1762,2IKYK@201174,COG3871@1,COG3871@2 NA|NA|NA S PFAM pyridoxamine 5'-phosphate OLIIENHM_02874 557599.MKAN_01870 2.5e-98 365.2 Mycobacteriaceae MA20_24385 Bacteria 2337V@1762,2GNPI@201174,COG0300@1,COG0300@2 NA|NA|NA S Short-chain dehydrogenase reductase sdr OLIIENHM_02875 164757.Mjls_2520 4.5e-150 537.7 Mycobacteriaceae cobL GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 2.1.1.132 ko:K00595 ko00860,ko01100,map00860,map01100 R05149 RC00003,RC01279 ko00000,ko00001,ko01000 iNJ661.Rv2072c Bacteria 236JN@1762,2GM8G@201174,COG2241@1,COG2241@2,COG2242@1,COG2242@2 NA|NA|NA H Precorrin-6Y C5,15-methyltransferase (Decarboxylating) OLIIENHM_02876 262316.MAP_1816c 5.6e-106 390.6 Mycobacteriaceae cobM 1.3.1.76,2.1.1.133,2.1.1.271,4.99.1.4 ko:K02304,ko:K05936 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03947,R05181,R05810 RC00003,RC01012,RC01034,RC01294,RC02049 ko00000,ko00001,ko00002,ko01000 Bacteria 232JY@1762,2GJ97@201174,COG2875@1,COG2875@2 NA|NA|NA H Belongs to the precorrin methyltransferase family OLIIENHM_02877 931627.MycrhDRAFT_3919 9.3e-90 336.7 Mycobacteriaceae cobK 1.3.1.106,1.3.1.54,1.3.1.76,2.1.1.131,2.1.1.132,3.7.1.12,4.99.1.4 ko:K00595,ko:K02304,ko:K05895,ko:K05934,ko:K13541 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03947,R05149,R05150,R05180,R05809,R05812,R07772 RC00003,RC01012,RC01034,RC01279,RC01280,RC01293,RC01545,RC02097,RC03471 ko00000,ko00001,ko00002,ko01000 Bacteria 233M9@1762,2GMYZ@201174,COG2099@1,COG2099@2 NA|NA|NA H reductase OLIIENHM_02878 1078020.KEK_00150 3.5e-229 800.8 Mycobacteriaceae cobI GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.1.1.130,2.1.1.131,2.1.1.151,3.7.1.12 ko:K03394,ko:K05934,ko:K13540,ko:K13541 ko00860,ko01100,map00860,map01100 R03948,R05180,R05808,R05809,R07772 RC00003,RC01035,RC01293,RC01545,RC01662,RC02097,RC03471 ko00000,ko00001,ko01000 iAF987.Gmet_0482 Bacteria 2335W@1762,2GMIR@201174,COG1010@1,COG1010@2,COG2243@1,COG2243@2 NA|NA|NA H Belongs to the precorrin methyltransferase family OLIIENHM_02879 931627.MycrhDRAFT_3916 8.9e-89 333.2 Mycobacteriaceae cobH 1.7.7.1,2.1.1.130,2.1.1.151,5.4.99.60,5.4.99.61 ko:K00366,ko:K03394,ko:K06042 ko00860,ko00910,ko01100,ko01120,map00860,map00910,map01100,map01120 M00531 R00790,R03948,R05177,R05808,R05814 RC00003,RC00176,RC01035,RC01292,RC01662,RC01980 ko00000,ko00001,ko00002,ko01000 Bacteria 233B2@1762,2GK0B@201174,COG2082@1,COG2082@2 NA|NA|NA H Precorrin-8X methylmutase OLIIENHM_02880 1440774.Y900_000060 3e-143 515.0 Mycobacteriaceae cobG 1.14.13.83,1.7.7.1,5.4.99.60,5.4.99.61 ko:K00366,ko:K02229,ko:K06042 ko00860,ko00910,ko01100,ko01120,map00860,map00910,map01100,map01120 M00531 R00790,R05177,R05217,R05814 RC00176,RC01292,RC01979,RC01980 ko00000,ko00001,ko00002,ko01000 Bacteria 233KF@1762,2GNUG@201174,COG0155@1,COG0155@2 NA|NA|NA C Precorrin-3B synthase OLIIENHM_02881 931627.MycrhDRAFT_3914 1.7e-51 209.9 Mycobacteriaceae Bacteria 236WR@1762,2ESVE@1,2I8VG@201174,33KDT@2 NA|NA|NA S Domain of unknown function (DUF4129) OLIIENHM_02882 931627.MycrhDRAFT_3913 2.6e-37 161.8 Mycobacteriaceae Bacteria 238SD@1762,2A3DE@1,2IM2D@201174,30RVW@2 NA|NA|NA OLIIENHM_02883 1440774.Y900_015720 2.5e-88 331.6 Mycobacteriaceae spoU 2.1.1.185 ko:K03218 ko00000,ko01000,ko03009 Bacteria 2330U@1762,2GM1A@201174,COG0566@1,COG0566@2 NA|NA|NA J tRNA rRNA methyltransferase, SpoU OLIIENHM_02884 931627.MycrhDRAFT_2968 4.2e-34 151.8 Mycobacteriaceae Bacteria 23898@1762,2A63I@1,2IE3Z@201174,30UVZ@2 NA|NA|NA OLIIENHM_02885 1440774.Y900_015685 7.5e-82 310.1 Mycobacteriaceae pyrE 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 iJN678.umpS Bacteria 234U1@1762,2GKUQ@201174,COG0461@1,COG0461@2 NA|NA|NA F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) OLIIENHM_02886 1440774.Y900_015680 3.3e-109 401.4 Mycobacteriaceae ko:K07124 ko00000 Bacteria 2357G@1762,2GKJE@201174,COG0300@1,COG0300@2 NA|NA|NA S Belongs to the short-chain dehydrogenases reductases (SDR) family OLIIENHM_02887 1440774.Y900_015675 2e-111 408.7 Mycobacteriaceae Bacteria 23569@1762,2DEM0@1,2GMFR@201174,2ZNE6@2 NA|NA|NA OLIIENHM_02888 931627.MycrhDRAFT_4866 4.7e-219 767.3 Mycobacteriaceae MA20_16190 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 234I8@1762,2GN0J@201174,COG2307@1,COG2307@2,COG2308@1,COG2308@2 NA|NA|NA E Circularly permuted ATP-grasp type 2 OLIIENHM_02889 931627.MycrhDRAFT_4867 3.3e-137 494.6 Mycobacteriaceae GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 2334E@1762,2HDEK@201174,COG1305@1,COG1305@2 NA|NA|NA E transglutaminase-like OLIIENHM_02890 1440774.Y900_001445 7.6e-154 550.1 Mycobacteriaceae Bacteria 234DW@1762,2GKD6@201174,COG4307@1,COG4307@2 NA|NA|NA S protein conserved in bacteria OLIIENHM_02892 1440774.Y900_010050 1.7e-116 426.8 Actinobacteria Bacteria 2I7Y5@201174,COG4932@1,COG4932@2 NA|NA|NA M domain protein OLIIENHM_02893 272631.ML2177 1.7e-146 525.4 Bacteria deoD_1 2.4.2.3 ko:K00757 ko00240,ko00983,ko01100,map00240,map00983,map01100 R01876,R02484,R08229 RC00063 ko00000,ko00001,ko01000 Bacteria COG2820@1,COG2820@2 NA|NA|NA F uridine phosphorylase activity OLIIENHM_02894 1444309.JAQG01000080_gene4010 1.6e-58 233.0 Paenibacillaceae deoC GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 4.1.2.4,5.4.2.8 ko:K01619,ko:K01840 ko00030,ko00051,ko00520,ko01100,ko01110,ko01130,map00030,map00051,map00520,map01100,map01110,map01130 M00114 R01066,R01818 RC00408,RC00436,RC00437 ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS00835,iYO844.BSU39420 Bacteria 1TPAJ@1239,26QH3@186822,4HAAJ@91061,COG0274@1,COG0274@2 NA|NA|NA F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate OLIIENHM_02895 196162.Noca_3526 5.6e-175 620.9 Propionibacteriales pgcA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 5.4.2.2,5.4.2.8 ko:K01835,ko:K01840 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114,M00549 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ3Q@201174,4DMY7@85009,COG1109@1,COG1109@2 NA|NA|NA G Phosphoglucomutase/phosphomannomutase, C-terminal domain OLIIENHM_02896 1380390.JIAT01000010_gene3597 9.5e-63 248.1 Rubrobacteria Bacteria 2GIUM@201174,4CRH0@84995,COG0477@1,COG0477@2 NA|NA|NA EGP Sugar (and other) transporter OLIIENHM_02897 272631.ML2174 2.5e-55 221.5 Mycobacteriaceae cdd GO:0003674,GO:0003824,GO:0004126,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006206,GO:0006213,GO:0006216,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008655,GO:0009056,GO:0009058,GO:0009112,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009972,GO:0009987,GO:0016020,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0019856,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042455,GO:0043094,GO:0043100,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046087,GO:0046108,GO:0046109,GO:0046112,GO:0046131,GO:0046132,GO:0046133,GO:0046134,GO:0046135,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0047844,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0072529,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659 2.4.2.4,3.5.4.5 ko:K00758,ko:K01489 ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219 R01570,R01878,R02484,R02485,R08221,R08222,R08230 RC00063,RC00074,RC00514 ko00000,ko00001,ko01000 Bacteria 239D2@1762,2IHP7@201174,COG0295@1,COG0295@2 NA|NA|NA F cytidine deaminase OLIIENHM_02898 710687.KI912270_gene1604 4.5e-231 807.4 Mycobacteriaceae yedY ko:K07147 ko00000,ko01000 Bacteria 232EE@1762,2GIZH@201174,COG2041@1,COG2041@2,COG4117@1,COG4117@2 NA|NA|NA C Prokaryotic cytochrome b561 OLIIENHM_02899 1440774.Y900_024670 8.7e-50 203.4 Mycobacteriaceae Bacteria 239EI@1762,2BFCU@1,2IESH@201174,32965@2 NA|NA|NA OLIIENHM_02901 1297570.MESS4_150046 3.6e-12 77.0 Alphaproteobacteria yjdI 1.6.3.4 ko:K07397,ko:K22405 ko00000,ko01000 Bacteria 1RCN9@1224,2U878@28211,COG3369@1,COG3369@2,COG3592@1,COG3592@2 NA|NA|NA S CDGSH-type zinc finger. Function unknown. OLIIENHM_02902 1370121.AUWS01000020_gene6615 7.6e-197 693.3 Mycobacteriaceae yjcD GO:0003674,GO:0005215,GO:0005345,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006863,GO:0008150,GO:0015205,GO:0015208,GO:0015851,GO:0015854,GO:0016020,GO:0022857,GO:0035344,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:0098657,GO:0098710,GO:0098739,GO:1903716,GO:1904823 ko:K06901 ko00000,ko02000 2.A.1.40 Bacteria 232TJ@1762,2GKYD@201174,COG2252@1,COG2252@2 NA|NA|NA S PFAM Xanthine uracil vitamin C permease OLIIENHM_02903 318424.EU78_01095 7.8e-109 400.2 Mycobacteriaceae glpF ko:K02440 ko00000,ko02000 1.A.8.1,1.A.8.2 Bacteria 23916@1762,2GKK3@201174,COG0580@1,COG0580@2 NA|NA|NA U Belongs to the MIP aquaporin (TC 1.A.8) family OLIIENHM_02904 931627.MycrhDRAFT_0004 6.9e-159 568.2 Mycobacteriaceae Bacteria 2343H@1762,2I5V8@201174,COG1506@1,COG1506@2 NA|NA|NA E peptidase S15 OLIIENHM_02905 1298864.AUEQ01000023_gene1399 1.3e-80 306.2 Mycobacteriaceae Bacteria 234HC@1762,2GJ38@201174,COG2356@1,COG2356@2 NA|NA|NA L Protein of unknown function (DUF1524) OLIIENHM_02906 1265310.CCBD010000048_gene388 1.1e-107 396.4 Mycobacteriaceae Bacteria 235H3@1762,2GKI2@201174,COG1028@1,COG1028@2 NA|NA|NA IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) OLIIENHM_02907 931627.MycrhDRAFT_6085 0.0 1302.3 Mycobacteriaceae aceAb GO:0003674,GO:0003824,GO:0004451,GO:0016829,GO:0016830,GO:0016833 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 Bacteria 232A9@1762,2I926@201174,COG2224@1,COG2224@2 NA|NA|NA C Isocitrate lyase OLIIENHM_02908 1380386.JIAW01000005_gene1740 5e-26 124.4 Mycobacteriaceae Bacteria 239BP@1762,2IIW8@201174,COG0791@1,COG0791@2 NA|NA|NA M NLP P60 protein OLIIENHM_02909 1440774.Y900_024805 1.2e-218 765.8 Mycobacteriaceae aldh1 1.2.1.3,1.2.1.83 ko:K00128,ko:K19700 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00760,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00760,map00903,map00981,map01100,map01110,map01120,map01130 M00135,M00811 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146,R10105 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 Bacteria 233QF@1762,2GIWZ@201174,COG1012@1,COG1012@2 NA|NA|NA C Aldehyde dehydrogenase OLIIENHM_02910 547163.BN979_06175 8e-57 226.5 Mycobacteriaceae dtd GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106026,GO:0106074,GO:0140098,GO:0140101,GO:1901360 ko:K07560 ko00000,ko01000,ko03016 Bacteria 239CY@1762,2IKVR@201174,COG1490@1,COG1490@2 NA|NA|NA J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality OLIIENHM_02911 931627.MycrhDRAFT_6110 8.7e-80 303.1 Mycobacteriaceae Bacteria 23561@1762,2ESGC@1,2I8M9@201174,33K12@2 NA|NA|NA OLIIENHM_02912 931627.MycrhDRAFT_6113 1.1e-142 513.1 Mycobacteriaceae Bacteria 233NM@1762,2GJCV@201174,COG1018@1,COG1018@2 NA|NA|NA C oxidoreductase OLIIENHM_02913 1440774.Y900_024890 1.5e-134 485.7 Mycobacteriaceae ko:K07044 ko00000 Bacteria 233X4@1762,2H3JA@201174,COG3687@1,COG3687@2 NA|NA|NA S Metal-dependent hydrolase OLIIENHM_02914 1440774.Y900_024895 1.3e-35 156.0 Mycobacteriaceae Bacteria 23A18@1762,2AV9I@1,2IMG9@201174,31M0I@2 NA|NA|NA OLIIENHM_02915 1440774.Y900_024900 7.8e-232 809.7 Mycobacteriaceae phrB GO:0000166,GO:0000719,GO:0003674,GO:0003824,GO:0003913,GO:0003914,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006290,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0033554,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0071949,GO:0090304,GO:0097159,GO:0140097,GO:1901265,GO:1901360,GO:1901363 ko:K06876 ko00000 Bacteria 2385S@1762,2GMF6@201174,COG3046@1,COG3046@2 NA|NA|NA S deoxyribodipyrimidine OLIIENHM_02916 1440774.Y900_024970 1.1e-287 995.7 Mycobacteriaceae 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 Bacteria 23D1M@1762,2GIVE@201174,COG2114@1,COG2114@2,COG5000@1,COG5000@2 NA|NA|NA T Adenylyl- / guanylyl cyclase, catalytic domain OLIIENHM_02917 931627.MycrhDRAFT_6130 9.6e-192 676.4 Mycobacteriaceae Bacteria 23CNR@1762,2GZI1@201174,COG0664@1,COG0664@2,COG0668@1,COG0668@2 NA|NA|NA MT Mechanosensitive ion channel OLIIENHM_02918 557599.MKAN_13675 2.8e-60 238.0 Mycobacteriaceae Bacteria 238UM@1762,2IM6D@201174,COG4119@1,COG4119@2 NA|NA|NA L pfam nudix OLIIENHM_02919 931627.MycrhDRAFT_6135 0.0 1138.3 Mycobacteriaceae malQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.4.1.18,2.4.1.25,3.2.1.196,5.4.99.15 ko:K00700,ko:K00705,ko:K02438,ko:K06044 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01824,R02110,R02111,R05196,R09995 RC00049 ko00000,ko00001,ko00002,ko01000,ko04147 CBM48,GH13,GH77 iJN678.malQ Bacteria 232KW@1762,2GM5Z@201174,COG1640@1,COG1640@2 NA|NA|NA G 4-alpha-glucanotransferase OLIIENHM_02920 1440774.Y900_025005 2e-36 158.3 Mycobacteriaceae mmr ko:K03297 ko00000,ko02000 2.A.7.1 Bacteria 23A80@1762,2IKQZ@201174,COG2076@1,COG2076@2 NA|NA|NA P Multidrug resistance protein OLIIENHM_02921 710685.MycrhN_4793 2.9e-38 164.5 Mycobacteriaceae ebrB ko:K03297 ko00000,ko02000 2.A.7.1 Bacteria 23A7I@1762,2IQ9R@201174,COG2076@1,COG2076@2 NA|NA|NA P Small multidrug resistance protein OLIIENHM_02922 931627.MycrhDRAFT_6800 4.9e-147 527.3 Mycobacteriaceae erg3 GO:0003674,GO:0003824,GO:0004497,GO:0006629,GO:0006643,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016705,GO:0016714,GO:0044237,GO:0044238,GO:0044255,GO:0050479,GO:0055114,GO:0071704 Bacteria 2340C@1762,2GMF0@201174,COG3000@1,COG3000@2 NA|NA|NA I sterol desaturase OLIIENHM_02923 1440774.Y900_025030 1.9e-59 235.3 Mycobacteriaceae ko:K07228 ko00000 Bacteria 238PD@1762,2IFBQ@201174,COG0490@1,COG0490@2 NA|NA|NA P regulatory, ligand-binding protein related to C-terminal domains of K channels OLIIENHM_02924 931627.MycrhDRAFT_6798 1.3e-146 526.2 Mycobacteriaceae ko:K03455 ko00000 2.A.37 Bacteria 2378Q@1762,2GJ69@201174,COG0475@1,COG0475@2 NA|NA|NA P Probably involved in transport of undeterminated substrate (possibly cations Na H) across the membrane. thought to be responsible for the translocation of the substrate across the membrane OLIIENHM_02925 931627.MycrhDRAFT_6797 1.3e-215 755.7 Mycobacteriaceae Bacteria 234RU@1762,2GJQ9@201174,COG0665@1,COG0665@2 NA|NA|NA E PFAM FAD dependent oxidoreductase OLIIENHM_02926 1370120.AUWR01000044_gene3904 1.1e-31 143.3 Mycobacteriaceae Bacteria 234MC@1762,2IAZ9@201174,COG1652@1,COG1652@2 NA|NA|NA S Bulb-type mannose-specific lectin OLIIENHM_02927 1440774.Y900_025040 1.6e-78 299.3 Mycobacteriaceae GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 Bacteria 236P9@1762,29WEC@1,2I8VH@201174,30I04@2 NA|NA|NA OLIIENHM_02928 1440774.Y900_025060 2.3e-233 814.7 Mycobacteriaceae Bacteria 233SE@1762,2GKS3@201174,COG1053@1,COG1053@2 NA|NA|NA C Succinate dehydrogenase fumarate reductase flavoprotein subunit OLIIENHM_02929 1440774.Y900_025065 3.6e-242 844.3 Mycobacteriaceae yddA GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0043207,GO:0044403,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071944,GO:0075136 ko:K02471 ko02010,map02010 ko00000,ko00001,ko02000 3.A.1.203.11,3.A.1.203.4 Bacteria 232RW@1762,2IAEM@201174,COG4178@1,COG4178@2 NA|NA|NA S ABC transporter OLIIENHM_02930 1440774.Y900_025065 2.6e-272 944.5 Mycobacteriaceae yddA GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0043207,GO:0044403,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071944,GO:0075136 ko:K02471 ko02010,map02010 ko00000,ko00001,ko02000 3.A.1.203.11,3.A.1.203.4 Bacteria 232RW@1762,2IAEM@201174,COG4178@1,COG4178@2 NA|NA|NA S ABC transporter OLIIENHM_02931 710686.Mycsm_03253 2.4e-255 887.9 Mycobacteriaceae ilvG GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030976,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1820 Bacteria 232TN@1762,2GM6Y@201174,COG0028@1,COG0028@2 NA|NA|NA EH Belongs to the TPP enzyme family OLIIENHM_02932 1440774.Y900_025070 0.0 1297.7 Mycobacteriaceae secA2 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009405,GO:0009605,GO:0009607,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030312,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0035821,GO:0036094,GO:0040007,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043207,GO:0043492,GO:0043952,GO:0044003,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0050896,GO:0051179,GO:0051234,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052564,GO:0052572,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0075136,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 Bacteria 234Y4@1762,2GKZE@201174,COG0653@1,COG0653@2 NA|NA|NA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane OLIIENHM_02933 931627.MycrhDRAFT_6788 6.6e-78 297.0 Mycobacteriaceae pgsA GO:0003674,GO:0003824,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 Bacteria 236BF@1762,2GM3F@201174,COG0558@1,COG0558@2 NA|NA|NA I CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase OLIIENHM_02934 1440774.Y900_025080 1.4e-92 346.3 Mycobacteriaceae GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 Bacteria 234FX@1762,2GMS5@201174,COG3879@1,COG3879@2 NA|NA|NA S Bacterial protein of unknown function (DUF881) OLIIENHM_02935 164757.Mjls_2878 3.2e-45 187.6 Mycobacteriaceae sbp Bacteria 23A02@1762,2IKJW@201174,COG3856@1,COG3856@2 NA|NA|NA S Protein of unknown function (DUF1290) OLIIENHM_02936 318424.EU78_13945 1.3e-96 359.4 Mycobacteriaceae GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 Bacteria 233T1@1762,2GJ3C@201174,COG3879@1,COG3879@2 NA|NA|NA S Bacterial protein of unknown function (DUF881) OLIIENHM_02937 1440774.Y900_025095 9.8e-54 216.1 Mycobacteriaceae gcvH ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 iNJ661.Rv1826 Bacteria 239DN@1762,2IKN2@201174,COG0509@1,COG0509@2 NA|NA|NA E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein OLIIENHM_02938 710685.MycrhN_4815 3e-68 264.6 Mycobacteriaceae garA GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006110,GO:0006140,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009894,GO:0009895,GO:0009987,GO:0010563,GO:0010675,GO:0010677,GO:0016020,GO:0016310,GO:0019219,GO:0019220,GO:0019222,GO:0019538,GO:0030312,GO:0030808,GO:0030809,GO:0030811,GO:0030812,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031329,GO:0031330,GO:0036211,GO:0042325,GO:0042326,GO:0042802,GO:0043170,GO:0043412,GO:0043457,GO:0043467,GO:0043470,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045820,GO:0045912,GO:0045934,GO:0045936,GO:0045980,GO:0046777,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051174,GO:0051193,GO:0051195,GO:0051196,GO:0051198,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:1900371,GO:1900372,GO:1900542,GO:1900543,GO:1901564,GO:1903578,GO:1903579,GO:2001169,GO:2001170 Bacteria 238MJ@1762,2GK99@201174,COG1716@1,COG1716@2 NA|NA|NA T Fha domain OLIIENHM_02939 931627.MycrhDRAFT_6782 1.2e-105 389.4 Mycobacteriaceae merR1 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 Bacteria 232TE@1762,2HBV6@201174,COG0789@1,COG0789@2 NA|NA|NA K Transcriptional regulator OLIIENHM_02940 1440774.Y900_025110 4.5e-72 277.3 Mycobacteriaceae GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 ko:K03617,ko:K08999 ko00000 Bacteria 234Z1@1762,2GN26@201174,COG1259@1,COG1259@2 NA|NA|NA S Bifunctional nuclease OLIIENHM_02941 1209984.BN978_06490 4.3e-99 367.5 Mycobacteriaceae merR2 Bacteria 2338S@1762,2GM67@201174,COG0789@1,COG0789@2 NA|NA|NA K transcriptional OLIIENHM_02944 1440774.Y900_012445 0.0 1812.0 Mycobacteriaceae gltB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016020,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 Bacteria 2343P@1762,2GN09@201174,COG0067@1,COG0067@2,COG0069@1,COG0069@2,COG0070@1,COG0070@2 NA|NA|NA E glutamate synthase OLIIENHM_02945 931627.MycrhDRAFT_0340 7e-99 366.7 Mycobacteriaceae ptrB 3.4.21.83 ko:K01354 ko05142,ko05143,map05142,map05143 ko00000,ko00001,ko01000,ko01002 Bacteria 233WC@1762,2GNA9@201174,COG1770@1,COG1770@2 NA|NA|NA E Oligopeptidase OLIIENHM_02946 1380386.JIAW01000003_gene742 1.4e-82 312.8 Mycobacteriaceae ko:K06986 ko00000 Bacteria 233ZM@1762,2HAXX@201174,COG3233@1,COG3233@2 NA|NA|NA S Uncharacterized protein conserved in bacteria (DUF2334) OLIIENHM_02947 1440774.Y900_009700 4.2e-112 411.0 Mycobacteriaceae Bacteria 2364G@1762,2GK47@201174,COG1028@1,COG1028@2 NA|NA|NA IQ reductase OLIIENHM_02948 1440774.Y900_009695 1.1e-102 379.4 Mycobacteriaceae Bacteria 232PM@1762,2GNHK@201174,COG2220@1,COG2220@2 NA|NA|NA S beta-lactamase OLIIENHM_02949 1440774.Y900_009690 3.1e-76 291.6 Mycobacteriaceae Bacteria 238AI@1762,28Y2U@1,2IAJG@201174,2ZJYE@2 NA|NA|NA OLIIENHM_02950 931627.MycrhDRAFT_0346 1.3e-29 135.2 Mycobacteriaceae purS 6.3.2.6,6.3.5.3 ko:K01923,ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463,R04591 RC00010,RC00064,RC00162,RC01160 ko00000,ko00001,ko00002,ko01000 iYO844.BSU06460 Bacteria 23AP3@1762,2GQV4@201174,COG1828@1,COG1828@2 NA|NA|NA F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL OLIIENHM_02951 1440774.Y900_009680 3.1e-116 424.5 Mycobacteriaceae purQ GO:0003674,GO:0003824,GO:0004642,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 Bacteria 232RZ@1762,2GMJY@201174,COG0047@1,COG0047@2 NA|NA|NA F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL OLIIENHM_02952 931627.MycrhDRAFT_0352 2.3e-192 678.3 Mycobacteriaceae apeB GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564 3.4.11.21 ko:K01267 ko00000,ko01000,ko01002,ko04131 Bacteria 233BY@1762,2GKW4@201174,COG1362@1,COG1362@2 NA|NA|NA E M18 family aminopeptidase 2 OLIIENHM_02953 1298864.AUEQ01000016_gene3817 1.6e-39 168.7 Mycobacteriaceae Bacteria 239XA@1762,2IQJB@201174,COG0346@1,COG0346@2 NA|NA|NA E glyoxalase OLIIENHM_02954 1440774.Y900_009655 0.0 1382.5 Mycobacteriaceae purL GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 Bacteria 2349K@1762,2GKG6@201174,COG0046@1,COG0046@2 NA|NA|NA F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL OLIIENHM_02955 931627.MycrhDRAFT_0356 2.8e-262 911.0 Mycobacteriaceae Bacteria 234IE@1762,2GKB5@201174,COG4425@1,COG4425@2 NA|NA|NA S membrane OLIIENHM_02956 1440774.Y900_015645 2.2e-30 138.3 Mycobacteriaceae Bacteria 233JW@1762,2HRC6@201174,COG1280@1,COG1280@2 NA|NA|NA E Sap, sulfolipid-1-addressing protein OLIIENHM_02957 1440774.Y900_015635 3.6e-22 110.5 Mycobacteriaceae Bacteria 23B9W@1762,2B162@1,2GSK6@201174,31TK4@2 NA|NA|NA OLIIENHM_02958 1440774.Y900_015630 8.4e-294 1015.8 Mycobacteriaceae acsA 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 237PW@1762,2GNE8@201174,COG0365@1,COG0365@2 NA|NA|NA I synthetase OLIIENHM_02959 1440774.Y900_015625 2.9e-142 511.5 Mycobacteriaceae pdhA 1.2.4.1,1.2.4.4 ko:K00161,ko:K00162,ko:K11381,ko:K21416 ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00036,M00307 R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 234F0@1762,2IBRC@201174,COG1071@1,COG1071@2 NA|NA|NA C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) OLIIENHM_02960 1101188.KI912155_gene2609 4e-136 491.1 Actinobacteria pdhA 1.2.4.1,1.2.4.4 ko:K00162,ko:K11381 ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00036,M00307 R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2GKFE@201174,COG0022@1,COG0022@2 NA|NA|NA C Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit OLIIENHM_02962 1440774.Y900_016520 2.5e-203 714.5 Mycobacteriaceae aldA GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0071944,GO:0075136 ko:K00138,ko:K18370 ko00010,ko00620,ko00640,ko01100,ko01110,ko01120,map00010,map00620,map00640,map01100,map01110,map01120 R00711,R10703 RC00047,RC00545 ko00000,ko00001,ko01000 Bacteria 234Y9@1762,2GIWZ@201174,COG1012@1,COG1012@2 NA|NA|NA C Belongs to the aldehyde dehydrogenase family OLIIENHM_02963 1440774.Y900_016525 2e-52 211.8 Mycobacteriaceae ko:K09959 ko00000 Bacteria 238S6@1762,2IKTA@201174,COG3564@1,COG3564@2 NA|NA|NA S Protein of unknown function (DUF779) OLIIENHM_02964 1440774.Y900_016530 3.6e-26 124.0 Mycobacteriaceae Bacteria 23AJH@1762,2C3BM@1,2IREC@201174,3034X@2 NA|NA|NA S Putative holin OLIIENHM_02965 1440774.Y900_016535 1.2e-46 193.4 Mycobacteriaceae Bacteria 239HI@1762,2ATNP@1,2IIZZ@201174,31J77@2 NA|NA|NA OLIIENHM_02966 700508.D174_05270 2.5e-232 811.2 Mycobacteriaceae lpd GO:0000166,GO:0003674,GO:0003824,GO:0004148,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0009987,GO:0015036,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0016667,GO:0016668,GO:0019725,GO:0019899,GO:0032991,GO:0035375,GO:0036094,GO:0040007,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0045454,GO:0048037,GO:0050660,GO:0050662,GO:0050789,GO:0050794,GO:0051287,GO:0055114,GO:0065007,GO:0065008,GO:0070404,GO:0071944,GO:0097159,GO:1901265,GO:1901363,GO:1902494,GO:1990204 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 233U4@1762,2GIXY@201174,COG1249@1,COG1249@2 NA|NA|NA C Dehydrogenase OLIIENHM_02967 1440774.Y900_016545 2.3e-22 111.3 Mycobacteriaceae Bacteria 23B8H@1762,2B0XH@1,2GS1D@201174,31TAB@2 NA|NA|NA OLIIENHM_02968 1122182.KB903838_gene4022 5.6e-82 310.8 Micromonosporales ksgA GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182,2.1.1.197,2.5.1.134 ko:K02169,ko:K02528,ko:K17216,ko:K17462 ko00270,ko00780,ko01100,ko01230,map00270,map00780,map01100,map01230 M00572,M00609 R09543,R10305,R10404,R10716 RC00003,RC00020,RC00069,RC00460,RC03257 ko00000,ko00001,ko00002,ko01000,ko03009 Bacteria 2GIZ8@201174,4DBCD@85008,COG0030@1,COG0030@2 NA|NA|NA J Methyltransferase domain OLIIENHM_02969 1120797.KB908258_gene1289 5.3e-131 474.6 Mycobacteriaceae Bacteria 232ST@1762,2GP2N@201174,COG1403@1,COG1403@2 NA|NA|NA V HNH endonuclease OLIIENHM_02971 1440774.Y900_016555 3.5e-78 297.7 Mycobacteriaceae Bacteria 233PS@1762,2IB85@201174,COG2128@1,COG2128@2 NA|NA|NA S Carboxymuconolactone decarboxylase OLIIENHM_02972 557599.MKAN_18240 3.1e-241 840.9 Mycobacteriaceae ramB GO:0001666,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0006950,GO:0008150,GO:0009628,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0036293,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070482,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 ko:K07110,ko:K21686,ko:K22300 ko00000,ko03000 Bacteria 233A3@1762,2GMWU@201174,COG1396@1,COG1396@2,COG3800@1,COG3800@2 NA|NA|NA K transcriptional OLIIENHM_02973 1440774.Y900_016565 3.6e-130 471.1 Mycobacteriaceae 3.1.2.21 ko:K01071 ko00061,ko01100,map00061,map01100 R04014,R08157,R08158 RC00014,RC00039 ko00000,ko00001,ko01000,ko01004 Bacteria 232UZ@1762,2H0CD@201174,COG3884@1,COG3884@2 NA|NA|NA I Acyl-ACP thioesterase OLIIENHM_02974 246196.MSMEI_0889 1.3e-227 795.4 Mycobacteriaceae aceA GO:0001101,GO:0001666,GO:0003674,GO:0003824,GO:0004451,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006081,GO:0006082,GO:0006097,GO:0006102,GO:0006950,GO:0008150,GO:0008152,GO:0009268,GO:0009405,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0010033,GO:0010034,GO:0010447,GO:0016020,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0019899,GO:0032787,GO:0033554,GO:0033993,GO:0035375,GO:0036293,GO:0036294,GO:0042221,GO:0043167,GO:0043169,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046421,GO:0046487,GO:0046677,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0070482,GO:0070542,GO:0070887,GO:0071453,GO:0071456,GO:0071704,GO:0071944,GO:0072350,GO:0075136,GO:0075141,GO:1901700 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 e_coli_core.b4015,iAF1260.b4015,iB21_1397.B21_03847,iBWG_1329.BWG_3671,iE2348C_1286.E2348C_4318,iEC042_1314.EC042_4377,iEC55989_1330.EC55989_4500,iECABU_c1320.ECABU_c45310,iECBD_1354.ECBD_4022,iECB_1328.ECB_03887,iECDH10B_1368.ECDH10B_4204,iECDH1ME8569_1439.ECDH1ME8569_3871,iECD_1391.ECD_03887,iECED1_1282.ECED1_4722,iECIAI1_1343.ECIAI1_4235,iECIAI39_1322.ECIAI39_4401,iECNA114_1301.ECNA114_4164,iECO103_1326.ECO103_4759,iECO111_1330.ECO111_4827,iECO26_1355.ECO26_5119,iECP_1309.ECP_4225,iECSE_1348.ECSE_4300,iECSF_1327.ECSF_3865,iECUMN_1333.ECUMN_4541,iECW_1372.ECW_m4374,iEKO11_1354.EKO11_4310,iETEC_1333.ETEC_4270,iEcDH1_1363.EcDH1_3982,iEcE24377_1341.EcE24377A_4557,iEcHS_1320.EcHS_A4249,iEcSMS35_1347.EcSMS35_4469,iEcolC_1368.EcolC_4015,iJN746.PP_4116,iJO1366.b4015,iJR904.b4015,iLF82_1304.LF82_0012,iNRG857_1313.NRG857_20015,iSDY_1059.SDY_4328,iUMNK88_1353.UMNK88_4859,iWFL_1372.ECW_m4374,iY75_1357.Y75_RS20880 Bacteria 232QK@1762,2GNAY@201174,COG2224@1,COG2224@2 NA|NA|NA C Isocitrate lyase OLIIENHM_02975 525368.HMPREF0591_3577 9.8e-131 473.0 Mycobacteriaceae fadB2 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006635,GO:0008150,GO:0008152,GO:0008610,GO:0008691,GO:0009056,GO:0009058,GO:0009062,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016042,GO:0016053,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019395,GO:0019752,GO:0030258,GO:0030312,GO:0030497,GO:0032787,GO:0034440,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044281,GO:0044282,GO:0044283,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:0072330,GO:0075136,GO:1901575,GO:1901576 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 iNJ661.Rv0468 Bacteria 234JX@1762,2GJBM@201174,COG1250@1,COG1250@2 NA|NA|NA I Dehydrogenase OLIIENHM_02976 1440774.Y900_016580 2e-147 528.5 Mycobacteriaceae mmaA1 GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008168,GO:0008610,GO:0009058,GO:0009059,GO:0009273,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016853,GO:0016859,GO:0019752,GO:0032259,GO:0032787,GO:0034645,GO:0042546,GO:0043170,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0046394,GO:0070589,GO:0071554,GO:0071704,GO:0071766,GO:0071767,GO:0071768,GO:0071840,GO:0072330,GO:1901576 2.1.1.79 ko:K00574 ko00000,ko01000 Bacteria 232Q2@1762,2GKIA@201174,COG2230@1,COG2230@2 NA|NA|NA M synthase OLIIENHM_02977 1440774.Y900_016585 2.1e-125 455.3 Mycobacteriaceae 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 23358@1762,2GKRN@201174,COG2326@1,COG2326@2 NA|NA|NA S polyphosphate kinase OLIIENHM_02978 931627.MycrhDRAFT_3127 5.1e-109 400.6 Mycobacteriaceae GO:0003674,GO:0003700,GO:0005575,GO:0005576,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141 Bacteria 233Y6@1762,2GN0W@201174,COG1309@1,COG1309@2 NA|NA|NA K Transcriptional regulator OLIIENHM_02979 931627.MycrhDRAFT_3128 7.3e-218 763.1 Mycobacteriaceae Bacteria 2335E@1762,2GKGM@201174,COG2733@1,COG2733@2 NA|NA|NA S membrane OLIIENHM_02980 1440774.Y900_016610 5.4e-52 210.3 Mycobacteriaceae clgR_2 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 Bacteria 2398E@1762,2IKVI@201174,COG1396@1,COG1396@2 NA|NA|NA K transcriptional OLIIENHM_02981 1380386.JIAW01000015_gene6453 3e-44 185.3 Mycobacteriaceae hbhA GO:0003674,GO:0005488,GO:0005515,GO:0005539,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0007155,GO:0007157,GO:0008150,GO:0008201,GO:0009986,GO:0016020,GO:0022610,GO:0030100,GO:0030312,GO:0032879,GO:0035821,GO:0042802,GO:0043167,GO:0043168,GO:0044003,GO:0044068,GO:0044077,GO:0044078,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045807,GO:0048259,GO:0048260,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051049,GO:0051050,GO:0051128,GO:0051130,GO:0051701,GO:0051704,GO:0051817,GO:0060627,GO:0065007,GO:0071944,GO:0097367,GO:0098609,GO:0098742,GO:1901681 ko:K16645 ko00000,ko00536 Bacteria 232MM@1762,2EBKM@1,2I5HJ@201174,335M1@2 NA|NA|NA S Required for extrapulmonary dissemination. mediates adherence to epithelial cells by binding to sulfated glycoconjugates present at the surface of these cells OLIIENHM_02982 931627.MycrhDRAFT_3131 1.2e-26 125.6 Mycobacteriaceae Bacteria 23A1Q@1762,2EHMU@1,2GQGA@201174,33BDI@2 NA|NA|NA S Protein of unknown function (DUF2516) OLIIENHM_02983 1440774.Y900_016625 6.2e-36 156.8 Mycobacteriaceae Bacteria 23A15@1762,2EB1C@1,2IM6C@201174,33526@2 NA|NA|NA S Protein of unknown function (DUF2599) OLIIENHM_02984 931627.MycrhDRAFT_3134 1.5e-81 309.3 Mycobacteriaceae GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 Bacteria 2334X@1762,2E4QP@1,2H34Q@201174,32ZJ9@2 NA|NA|NA S Protein of unknown function (DUF2993) OLIIENHM_02985 1440774.Y900_016640 6.5e-105 387.1 Mycobacteriaceae GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 ko:K11206 ko00000,ko01000 Bacteria 2337R@1762,2GMQA@201174,COG0388@1,COG0388@2 NA|NA|NA S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase OLIIENHM_02986 1440774.Y900_016645 2.8e-105 388.3 Mycobacteriaceae 2.1.1.104 ko:K00588 ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110 M00039,M00350 R01942,R06578 RC00003,RC00392 ko00000,ko00001,ko00002,ko01000 Bacteria 2328Y@1762,2GK2F@201174,COG4122@1,COG4122@2 NA|NA|NA S O-methyltransferase activity OLIIENHM_02987 931627.MycrhDRAFT_3137 1.1e-41 176.4 Mycobacteriaceae Bacteria 238YX@1762,294PY@1,2IH7K@201174,2ZS39@2 NA|NA|NA S Protein of unknown function (DUF2505) OLIIENHM_02988 1440774.Y900_016655 2.6e-59 235.0 Mycobacteriaceae Bacteria 23F7T@1762,2ED3C@1,2I4HH@201174,33708@2 NA|NA|NA S Protein of unknown function (DUF2505) OLIIENHM_02989 931627.MycrhDRAFT_3139 2.9e-132 478.4 Mycobacteriaceae murB GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008360,GO:0008762,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0022603,GO:0022604,GO:0030203,GO:0034645,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045229,GO:0048037,GO:0050660,GO:0050662,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0055114,GO:0065007,GO:0065008,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 iECED1_1282.ECED1_4683,iECUMN_1333.ECUMN_4498_AT6,iLF82_1304.LF82_1416,iNRG857_1313.NRG857_19845 Bacteria 232J7@1762,2GIV2@201174,COG0812@1,COG0812@2 NA|NA|NA M Cell wall formation OLIIENHM_02990 931627.MycrhDRAFT_3142 4.2e-109 401.0 Mycobacteriaceae sdh GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 234IZ@1762,2GMGQ@201174,COG4221@1,COG4221@2 NA|NA|NA S Belongs to the short-chain dehydrogenases reductases (SDR) family OLIIENHM_02991 931627.MycrhDRAFT_3144 4e-195 687.6 Mycobacteriaceae mshA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016740,GO:0016757,GO:0016758,GO:0044237,GO:0044249,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659 2.4.1.250 ko:K15521 ko00000,ko01000 Bacteria 233BW@1762,2GJ57@201174,COG0438@1,COG0438@2 NA|NA|NA M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway OLIIENHM_02992 1440774.Y900_016690 6.9e-74 283.5 Mycobacteriaceae Bacteria 2338Q@1762,2AZ39@1,2GMCY@201174,31R9K@2 NA|NA|NA S Putative bacterial sensory transduction regulator OLIIENHM_02993 710685.MycrhN_1121 1.5e-122 445.7 Mycobacteriaceae gpmA GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016020,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0031323,GO:0031329,GO:0032787,GO:0032991,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0060255,GO:0062012,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031 5.4.2.11 ko:K01834 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 Bacteria 2337Z@1762,2GK8F@201174,COG0588@1,COG0588@2 NA|NA|NA G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate OLIIENHM_02994 1440774.Y900_016700 3e-143 515.0 Mycobacteriaceae senX3 GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009405,GO:0009987,GO:0016020,GO:0016310,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044464,GO:0046777,GO:0051704,GO:0071704,GO:0071944,GO:1901564 2.7.13.3 ko:K07636,ko:K07768,ko:K11383 ko02020,map02020 M00434,M00443,M00505 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 2339A@1762,2GJY7@201174,COG5002@1,COG5002@2 NA|NA|NA T Histidine kinase OLIIENHM_02995 1194972.MVAC_14603 4.4e-110 404.1 Mycobacteriaceae Bacteria 234EX@1762,2GKFS@201174,COG0745@1,COG0745@2 NA|NA|NA K COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain OLIIENHM_02996 1440774.Y900_016710 1.3e-148 533.1 Mycobacteriaceae wcnC Bacteria 232UF@1762,2GK0M@201174,COG2148@1,COG2148@2 NA|NA|NA M sugar transferase OLIIENHM_02997 931627.MycrhDRAFT_3150 1.1e-149 536.6 Mycobacteriaceae Bacteria 237FJ@1762,2IRB6@201174,COG0438@1,COG0438@2 NA|NA|NA M PFAM Glycosyl transferase, group 1 OLIIENHM_02998 931627.MycrhDRAFT_3151 1e-172 613.2 Mycobacteriaceae ko:K03328 ko00000 2.A.66.2 Bacteria 238DK@1762,2H55P@201174,COG2244@1,COG2244@2 NA|NA|NA S Polysaccharide biosynthesis protein OLIIENHM_02999 350058.Mvan_5250 2.9e-49 201.8 Mycobacteriaceae Bacteria 239S2@1762,2E3DT@1,2IK8I@201174,32YCX@2 NA|NA|NA OLIIENHM_03000 931627.MycrhDRAFT_3153 5.2e-183 647.9 Mycobacteriaceae Bacteria 236VY@1762,2HRZ7@201174,COG3307@1,COG3307@2 NA|NA|NA M PFAM O-antigen OLIIENHM_03001 1440774.Y900_007055 9.3e-56 222.6 Mycobacteriaceae exoA 3.1.11.2 ko:K01142 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 233PN@1762,2GKIS@201174,COG0708@1,COG0708@2 NA|NA|NA L exodeoxyribonuclease III OLIIENHM_03002 931627.MycrhDRAFT_2420 0.0 1232.6 Mycobacteriaceae engXCA 3.2.1.14,3.2.1.4 ko:K01179,ko:K01183,ko:K20628 ko00500,ko00520,ko01100,map00500,map00520,map01100 R01206,R02334,R06200,R11307,R11308 RC00467 ko00000,ko00001,ko01000 GH18,GH5,GH9 Bacteria 23FHM@1762,2I2VY@201174,COG2730@1,COG2730@2 NA|NA|NA G Calx-beta domain OLIIENHM_03003 1209984.BN978_01013 3.4e-49 201.4 Mycobacteriaceae Bacteria 233SY@1762,2GNGT@201174,COG1309@1,COG1309@2 NA|NA|NA K Transcriptional regulator OLIIENHM_03004 1440774.Y900_007040 1.1e-147 529.6 Mycobacteriaceae lipA1 Bacteria 2362S@1762,2HH90@201174,COG1075@1,COG1075@2 NA|NA|NA S acetyltransferases and hydrolases with the alpha beta hydrolase fold OLIIENHM_03006 1440774.Y900_000610 5.8e-157 560.8 Mycobacteriaceae Bacteria 233AS@1762,2GN0Y@201174,COG1020@1,COG1020@2 NA|NA|NA Q D-alanine [D-alanyl carrier protein] ligase activity OLIIENHM_03007 1440774.Y900_000615 1.7e-145 522.7 Mycobacteriaceae Bacteria 233AS@1762,2GN0Y@201174,COG1020@1,COG1020@2 NA|NA|NA Q D-alanine [D-alanyl carrier protein] ligase activity OLIIENHM_03008 931627.MycrhDRAFT_5015 1.1e-208 732.6 Mycobacteriaceae pvdL Bacteria 232PE@1762,2GSQU@201174,COG1020@1,COG1020@2 NA|NA|NA Q COG1020 Non-ribosomal peptide synthetase modules and related proteins OLIIENHM_03009 1440774.Y900_000625 0.0 3159.0 Mycobacteriaceae ko:K12431,ko:K12433,ko:K12442 ko00000,ko01004 Bacteria 232E7@1762,2H477@201174,COG0604@1,COG0604@2,COG1028@1,COG1028@2,COG3321@1,COG3321@2 NA|NA|NA Q polyketide synthase OLIIENHM_03010 1172186.KB911477_gene94 2.2e-138 498.4 Mycobacteriaceae atpD GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 Bacteria 233KQ@1762,2GIY6@201174,COG0055@1,COG0055@2 NA|NA|NA F Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits OLIIENHM_03011 1440774.Y900_020205 1.2e-50 205.7 Mycobacteriaceae atpC GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 Bacteria 2397I@1762,2IHNZ@201174,COG0355@1,COG0355@2 NA|NA|NA C Produces ATP from ADP in the presence of a proton gradient across the membrane OLIIENHM_03012 1380386.JIAW01000013_gene2647 1.1e-56 226.1 Mycobacteriaceae Bacteria 238TM@1762,2E6YX@1,2IFIG@201174,331I5@2 NA|NA|NA S Protein of unknown function (DUF2550) OLIIENHM_03013 1440774.Y900_020215 1.1e-88 332.8 Mycobacteriaceae yvqK 2.5.1.17 ko:K00798 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 Bacteria 235U1@1762,2GMHN@201174,COG2096@1,COG2096@2 NA|NA|NA S adenosyltransferase OLIIENHM_03014 1440774.Y900_020220 6.4e-224 783.1 Mycobacteriaceae murA GO:0008150,GO:0040007 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 R00660 RC00350 ko00000,ko00001,ko01000,ko01011 Bacteria 233MB@1762,2GJPW@201174,COG0766@1,COG0766@2 NA|NA|NA M Belongs to the EPSP synthase family. MurA subfamily OLIIENHM_03015 246196.MSMEI_5985 4.6e-79 301.6 Mycobacteriaceae Bacteria 2388Z@1762,2IDMR@201174,COG5651@1,COG5651@2 NA|NA|NA N PE-PPE domain OLIIENHM_03016 1440774.Y900_004630 3.2e-74 285.0 Mycobacteriaceae ko:K07282 ko00000 Bacteria 236UC@1762,2GP72@201174,COG2843@1,COG2843@2 NA|NA|NA M D-alanyl-D-alanine carboxypeptidase OLIIENHM_03017 931627.MycrhDRAFT_0285 3e-241 841.3 Mycobacteriaceae Bacteria 232GB@1762,2GMIX@201174,COG2339@1,COG2339@2 NA|NA|NA S peptidase activity OLIIENHM_03018 931627.MycrhDRAFT_0286 3.3e-204 718.0 Mycobacteriaceae ko:K08677 ko00000,ko01002 Bacteria 23D3H@1762,2GMZ8@201174,COG4934@1,COG4934@2 NA|NA|NA O Peptidase S53 OLIIENHM_03019 931627.MycrhDRAFT_6081 4.6e-145 520.8 Mycobacteriaceae Bacteria 233GF@1762,2IA3C@201174,COG4638@1,COG4638@2 NA|NA|NA P Rieske 2Fe-2S OLIIENHM_03020 246196.MSMEI_0717 1.7e-188 665.2 Mycobacteriaceae 1.17.1.8,1.4.1.12,1.4.1.26 ko:K00215,ko:K21672 ko00261,ko00300,ko00310,ko00330,ko00472,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map00310,map00330,map00472,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R02825,R04198,R04199,R04200,R04201,R04687,R04688 RC00249,RC00478,RC00790 ko00000,ko00001,ko00002,ko01000 Bacteria 232NP@1762,2H86T@201174,COG3804@1,COG3804@2 NA|NA|NA S dihydrodipicolinate reductase OLIIENHM_03021 596151.DesfrDRAFT_0522 3.4e-84 318.9 Desulfovibrionales cbh 3.5.1.24 ko:K01442 ko00120,ko00121,ko01100,map00120,map00121,map01100 R02797,R03975,R03977,R04486,R04487,R05835 RC00090,RC00096 ko00000,ko00001,ko01000 Bacteria 1MWPQ@1224,2M7Z4@213115,2X2RT@28221,43DT5@68525,COG3049@1,COG3049@2 NA|NA|NA M Linear amide C-N hydrolases, choloylglycine hydrolase family OLIIENHM_03022 1299327.I546_3485 1.9e-204 718.8 Actinobacteria 2.3.1.20 ko:K00635 ko00561,ko01100,map00561,map01100 M00089 R02251 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 Bacteria 2IGNH@201174,COG1020@1,COG1020@2 NA|NA|NA Q Protein of unknown function (DUF1298) OLIIENHM_03023 1440774.Y900_004625 7e-81 307.0 Mycobacteriaceae Bacteria 239JZ@1762,2IDJT@201174,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family OLIIENHM_03024 1440774.Y900_004620 1.7e-247 861.7 Mycobacteriaceae GO:0003674,GO:0003824,GO:0004497,GO:0008150,GO:0008152,GO:0016491,GO:0016705,GO:0016709,GO:0055114 ko:K10215 ko00627,ko01120,map00627,map01120 R07836,R07837 RC02100,RC03121 ko00000,ko00001,ko01000 Bacteria 234YX@1762,2GJEA@201174,COG2072@1,COG2072@2 NA|NA|NA P Flavin-binding monooxygenase-like OLIIENHM_03025 931627.MycrhDRAFT_1725 3.2e-102 378.3 Mycobacteriaceae Bacteria 237PN@1762,2IH32@201174,COG2267@1,COG2267@2 NA|NA|NA I Serine aminopeptidase, S33 OLIIENHM_03026 700508.D174_06005 3.8e-90 338.2 Mycobacteriaceae Bacteria 238VS@1762,2ICE8@201174,COG0204@1,COG0204@2 NA|NA|NA I Phosphate acyltransferases OLIIENHM_03027 350058.Mvan_4726 1.1e-113 417.2 Mycobacteriaceae Bacteria 233V6@1762,2GNAQ@201174,COG5651@1,COG5651@2 NA|NA|NA N PFAM PE-PPE, C-terminal OLIIENHM_03028 931627.MycrhDRAFT_1742 7.8e-80 303.5 Mycobacteriaceae ddpX GO:0003674,GO:0003824,GO:0004180,GO:0004181,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009046,GO:0009605,GO:0009991,GO:0016787,GO:0019538,GO:0031667,GO:0042594,GO:0043170,GO:0044238,GO:0050896,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.13.22 ko:K07282,ko:K08641 ko01502,ko02020,map01502,map02020 M00651 ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504 Bacteria 2329Z@1762,2GK5P@201174,COG2173@1,COG2173@2 NA|NA|NA M Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide OLIIENHM_03029 1440774.Y900_018575 1.4e-108 399.4 Mycobacteriaceae ko:K07052 ko00000 Bacteria 23B76@1762,2I8AH@201174,COG1266@1,COG1266@2 NA|NA|NA S CAAX protease self-immunity OLIIENHM_03030 931627.MycrhDRAFT_1743 6.3e-82 310.5 Mycobacteriaceae pdtaR ko:K22010 M00839 ko00000,ko00002,ko02022 Bacteria 232BE@1762,2I8E6@201174,COG3707@1,COG3707@2 NA|NA|NA K Antar domain OLIIENHM_03031 1370125.AUWT01000003_gene4322 4.2e-13 81.3 Mycobacteriaceae Bacteria 23A17@1762,2AWE1@1,2IPAP@201174,31NA3@2 NA|NA|NA OLIIENHM_03032 1440774.Y900_004530 1.6e-69 269.2 Mycobacteriaceae ko:K13652 ko00000,ko03000 Bacteria 23618@1762,2IHU0@201174,COG3449@1,COG3449@2 NA|NA|NA L heme-binding protein OLIIENHM_03033 1440774.Y900_004520 9.9e-155 553.1 Mycobacteriaceae 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 Bacteria 23ETE@1762,2I8VD@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_03034 931627.MycrhDRAFT_1749 1e-205 722.6 Mycobacteriaceae MA20_04655 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 Bacteria 235UT@1762,2GM1Q@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_03035 931627.MycrhDRAFT_1752 7.7e-20 102.4 Mycobacteriaceae ybdD Bacteria 23B7T@1762,2GWNS@201174,COG2879@1,COG2879@2 NA|NA|NA S Selenoprotein, putative OLIIENHM_03036 700508.D174_10140 0.0 1139.8 Mycobacteriaceae cstA GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042594,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:0071944 ko:K06200 ko00000 Bacteria 2334I@1762,2GIYX@201174,COG1966@1,COG1966@2 NA|NA|NA T Carbon starvation protein OLIIENHM_03037 1440774.Y900_016835 5.7e-63 246.9 Mycobacteriaceae Bacteria 233U0@1762,2GP1U@201174,COG3662@1,COG3662@2 NA|NA|NA S protein conserved in bacteria OLIIENHM_03038 931627.MycrhDRAFT_3186 3.4e-74 284.6 Mycobacteriaceae Bacteria 235KV@1762,2IC64@201174,COG1309@1,COG1309@2 NA|NA|NA K Transcriptional regulator OLIIENHM_03039 1440774.Y900_016885 8.9e-38 163.7 Bacteria ko:K07400 ko00000 Bacteria COG0694@1,COG0694@2 NA|NA|NA O iron-sulfur cluster assembly OLIIENHM_03040 1440774.Y900_016890 1e-122 446.4 Mycobacteriaceae feoB ko:K04759 ko00000,ko02000 9.A.8.1 Bacteria 235FD@1762,2GTV2@201174,COG0370@1,COG0370@2 NA|NA|NA P Ferrous iron transport protein B C terminus OLIIENHM_03041 931627.MycrhDRAFT_6701 9.1e-49 199.5 Mycobacteriaceae corA ko:K03284 ko00000,ko02000 1.A.35.1,1.A.35.3 Bacteria 233R3@1762,2GKNZ@201174,COG0598@1,COG0598@2 NA|NA|NA P Mg2 transporter protein OLIIENHM_03042 1370120.AUWR01000013_gene3350 1.1e-11 75.5 Mycobacteriaceae Bacteria 23B7I@1762,2BIW5@1,2GTRF@201174,32D4A@2 NA|NA|NA OLIIENHM_03043 1121017.AUFG01000003_gene3343 8.8e-80 303.5 Intrasporangiaceae Bacteria 2H8JM@201174,4FG88@85021,COG0491@1,COG0491@2 NA|NA|NA S Metallo-beta-lactamase superfamily OLIIENHM_03044 164757.Mjls_0396 1e-21 109.8 Mycobacteriaceae rsbW 2.7.11.1 ko:K04757 ko00000,ko01000,ko01001,ko03021 Bacteria 23B26@1762,2GQFJ@201174,COG2172@1,COG2172@2 NA|NA|NA T Histidine kinase-like ATPase domain OLIIENHM_03045 1123377.AUIV01000016_gene295 8.4e-51 208.8 Gammaproteobacteria Bacteria 1R7HC@1224,1T5UV@1236,COG2199@1,COG2202@1,COG2202@2,COG3706@2 NA|NA|NA T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) OLIIENHM_03046 298655.KI912267_gene6941 1.5e-19 104.0 Actinobacteria Bacteria 2GZAJ@201174,COG4188@1,COG4188@2 NA|NA|NA S Platelet-activating factor acetylhydrolase, isoform II OLIIENHM_03047 1217718.ALOU01000034_gene2921 1.4e-50 207.2 Burkholderiaceae qor 1.1.1.1,1.6.5.5 ko:K00001,ko:K00344 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 Bacteria 1JZTH@119060,1MU4N@1224,2VIU4@28216,COG0604@1,COG0604@2 NA|NA|NA C Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily OLIIENHM_03048 1282876.BAOK01000002_gene133 6.2e-87 327.4 unclassified Alphaproteobacteria echA8_7 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 R03026 RC00831 ko00000,ko00001,ko01000 Bacteria 1MWZC@1224,2TRYS@28211,4BPKP@82117,COG1024@1,COG1024@2 NA|NA|NA I enoyl-CoA hydratase isomerase family OLIIENHM_03049 710687.KI912270_gene5992 4.5e-23 113.6 Mycobacteriaceae Bacteria 233YN@1762,2GKJA@201174,COG0491@1,COG0491@2 NA|NA|NA S Metallo-beta-lactamase superfamily OLIIENHM_03050 258533.BN977_01899 7.7e-17 92.8 Mycobacteriaceae Bacteria 23B6U@1762,2B07N@1,2GQTH@201174,31SIF@2 NA|NA|NA OLIIENHM_03051 525368.HMPREF0591_4966 1.1e-08 65.9 Mycobacteriaceae Bacteria 23B6U@1762,2B07N@1,2GQTH@201174,31SIF@2 NA|NA|NA OLIIENHM_03052 36809.MAB_2314c 1.3e-10 71.6 Mycobacteriaceae Bacteria 233YN@1762,2GKJA@201174,COG0491@1,COG0491@2 NA|NA|NA S Metallo-beta-lactamase superfamily OLIIENHM_03053 1054860.KB913030_gene165 2.3e-20 105.1 Actinobacteria 3.1.26.4 ko:K03469,ko:K09964 ko03030,map03030 ko00000,ko00001,ko01000,ko03032 Bacteria 2IM16@201174,COG3602@1,COG3602@2 NA|NA|NA S ACT domain OLIIENHM_03054 931627.MycrhDRAFT_6708 4.2e-103 380.9 Mycobacteriaceae Bacteria 233YN@1762,2GKJA@201174,COG0491@1,COG0491@2 NA|NA|NA S Metallo-beta-lactamase superfamily OLIIENHM_03055 196164.23493346 1.4e-72 280.4 Bacteria Bacteria 2E4RD@1,33NSC@2 NA|NA|NA OLIIENHM_03056 546266.NEIMUCOT_05235 4.8e-55 222.2 Betaproteobacteria Bacteria 1NJPV@1224,2E4RD@1,2W2WZ@28216,32ZJX@2 NA|NA|NA S Psort location Cytoplasmic, score 8.96 OLIIENHM_03058 931627.MycrhDRAFT_3624 3e-244 850.9 Mycobacteriaceae alfA 3.2.1.51 ko:K01206 ko00511,map00511 ko00000,ko00001,ko01000,ko04147 GH29 Bacteria 23693@1762,2HUEI@201174,COG3669@1,COG3669@2 NA|NA|NA G Alpha-L-fucosidase OLIIENHM_03060 164757.Mjls_0396 2.1e-22 112.1 Mycobacteriaceae rsbW 2.7.11.1 ko:K04757 ko00000,ko01000,ko01001,ko03021 Bacteria 23B26@1762,2GQFJ@201174,COG2172@1,COG2172@2 NA|NA|NA T Histidine kinase-like ATPase domain OLIIENHM_03062 164757.Mjls_5038 1.9e-18 97.8 Mycobacteriaceae ko:K05337 ko00000 Bacteria 23BRA@1762,2GUJE@201174,COG1141@1,COG1141@2 NA|NA|NA C Divergent 4Fe-4S mono-cluster OLIIENHM_03063 525368.HMPREF0591_5998 9.2e-92 343.2 Mycobacteriaceae Bacteria 2381F@1762,2IG2I@201174,COG2197@1,COG2197@2 NA|NA|NA K response regulator, receiver OLIIENHM_03064 525368.HMPREF0591_5999 1e-144 520.0 Mycobacteriaceae Bacteria 2360Y@1762,2IE0N@201174,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor OLIIENHM_03065 525368.HMPREF0591_6000 1.9e-207 728.4 Mycobacteriaceae 1.14.15.14 ko:K20497 ko00000,ko00199,ko01000 Bacteria 2359Y@1762,2GKCG@201174,COG2124@1,COG2124@2 NA|NA|NA C cytochrome p450 OLIIENHM_03066 525368.HMPREF0591_6001 6e-181 640.2 Mycobacteriaceae 1.1.1.1,1.1.1.284 ko:K00001,ko:K00121 ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204 R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273 ko00000,ko00001,ko01000 Bacteria 232XA@1762,2GM8C@201174,COG1062@1,COG1062@2 NA|NA|NA C alcohol dehydrogenase OLIIENHM_03068 1440774.Y900_007805 2.8e-126 458.4 Mycobacteriaceae ppx GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 R03409 RC00002 ko00000,ko00001,ko01000 Bacteria 2367J@1762,2GJBN@201174,COG0248@1,COG0248@2 NA|NA|NA FP PFAM Ppx GppA phosphatase OLIIENHM_03069 547163.BN979_05078 6.1e-77 293.5 Mycobacteriaceae ppx2 3.6.1.11,3.6.1.40 ko:K01524,ko:K09009 ko00230,map00230 R03409 RC00002 ko00000,ko00001,ko01000 Bacteria 23546@1762,2I8CS@201174,COG1507@1,COG1507@2 NA|NA|NA S Protein of unknown function (DUF501) OLIIENHM_03070 1440774.Y900_007815 6.3e-72 277.3 Mycobacteriaceae divIC ko:K05589,ko:K13052 ko00000,ko03036 Bacteria 2370E@1762,2GQH7@201174,COG2919@1,COG2919@2 NA|NA|NA D Septum formation initiator OLIIENHM_03071 1120797.KB908264_gene3743 2.1e-214 751.5 Mycobacteriaceae eno 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 Bacteria 233AZ@1762,2GJAY@201174,COG0148@1,COG0148@2 NA|NA|NA G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis OLIIENHM_03072 1440774.Y900_007825 2.8e-105 388.3 Mycobacteriaceae lpqU Bacteria 233T3@1762,2GX49@201174,COG2951@1,COG2951@2 NA|NA|NA M Transglycosylase SLT domain OLIIENHM_03073 1078020.KEK_03166 3.8e-117 427.9 Mycobacteriaceae mazG GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0022607,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0035539,GO:0042454,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044464,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0047693,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.6.1.66 ko:K02428 ko00230,map00230 R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 Bacteria 234CA@1762,2GNKC@201174,COG1694@1,COG3956@2 NA|NA|NA S pyrophosphohydrolase OLIIENHM_03074 931627.MycrhDRAFT_0719 0.0 2034.2 Mycobacteriaceae mfd GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 ko:K03723 ko03420,map03420 ko00000,ko00001,ko01000,ko03400 Bacteria 2329T@1762,2GJ42@201174,COG1197@1,COG1197@2 NA|NA|NA L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site OLIIENHM_03075 216594.MMAR_4466 6.1e-96 357.1 Mycobacteriaceae icaR Bacteria 2358A@1762,2GMBW@201174,COG1309@1,COG1309@2 NA|NA|NA K Transcriptional regulator OLIIENHM_03077 1440774.Y900_007865 4e-225 787.3 Mycobacteriaceae glmU GO:0000270,GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0005975,GO:0005976,GO:0006022,GO:0006023,GO:0006024,GO:0006629,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009252,GO:0009273,GO:0009987,GO:0016051,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0019134,GO:0022610,GO:0030203,GO:0030260,GO:0033692,GO:0034637,GO:0034645,GO:0035635,GO:0040007,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044650,GO:0046872,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0070569,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1903509 2.3.1.157,2.7.7.23 ko:K04042,ko:K11528,ko:K16203 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000,ko01002 3.A.1.5.2 iJN678.glmU,iLJ478.TM1629 Bacteria 233WN@1762,2GJS1@201174,COG1207@1,COG1207@2 NA|NA|NA M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain OLIIENHM_03078 1209984.BN978_05701 2.6e-170 604.7 Mycobacteriaceae prs GO:0000287,GO:0003674,GO:0003824,GO:0004749,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006015,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0046390,GO:0046391,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901576 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 Bacteria 2344E@1762,2GJ9S@201174,COG0462@1,COG0462@2 NA|NA|NA F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) OLIIENHM_03079 1440774.Y900_007880 1.2e-64 253.1 Mycobacteriaceae lpqT GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 Bacteria 237FP@1762,2APGE@1,2I9KW@201174,31CXX@2 NA|NA|NA S Probable lipoprotein LpqN OLIIENHM_03080 1440774.Y900_007885 4.1e-124 451.1 Mycobacteriaceae Bacteria 235E5@1762,2GIYQ@201174,COG1028@1,COG1028@2 NA|NA|NA IQ Belongs to the short-chain dehydrogenases reductases (SDR) family OLIIENHM_03081 1370121.AUWS01000034_gene4068 6.2e-77 293.9 Mycobacteriaceae ctc GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02897 ko03010,map03010 M00178 ko00000,ko00001,ko00002,ko03011 Bacteria 234D4@1762,2GJPJ@201174,COG1825@1,COG1825@2 NA|NA|NA J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance OLIIENHM_03082 931627.MycrhDRAFT_0710 2.4e-93 348.2 Mycobacteriaceae pth GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016787,GO:0016788,GO:0040007,GO:0044464,GO:0052689,GO:0071944,GO:0140098,GO:0140101 3.1.1.29 ko:K01056 ko00000,ko01000,ko03012 Bacteria 2340N@1762,2GKCV@201174,COG0193@1,COG0193@2 NA|NA|NA J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis OLIIENHM_03083 1341646.CBMO010000118_gene1863 2.1e-21 107.8 Mycobacteriaceae Bacteria 23C1C@1762,2B25D@1,2GYJJ@201174,31X7R@2 NA|NA|NA OLIIENHM_03084 1341646.CBMO010000118_gene1863 1.9e-22 111.3 Mycobacteriaceae Bacteria 23C1C@1762,2B25D@1,2GYJJ@201174,31X7R@2 NA|NA|NA OLIIENHM_03085 1157943.KB892705_gene128 3.4e-34 151.4 Mycobacteriaceae Bacteria 23A97@1762,2AD2H@1,2INAD@201174,312QR@2 NA|NA|NA OLIIENHM_03086 1440774.Y900_007920 4.1e-287 993.4 Mycobacteriaceae pks16 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019752,GO:0030312,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070566,GO:0071704,GO:0071944,GO:0072330,GO:1901576 ko:K00666 ko00000,ko01000,ko01004 Bacteria 232VP@1762,2GMQP@201174,COG0318@1,COG0318@2 NA|NA|NA IQ Activates fatty acids by binding to coenzyme A OLIIENHM_03087 931627.MycrhDRAFT_0705 3.2e-143 514.6 Mycobacteriaceae ispE GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006629,GO:0006720,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0050515,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901576 2.1.1.182,2.7.1.148 ko:K00919,ko:K02528,ko:K16924 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096,M00582 R05634,R10716 RC00002,RC00003,RC01439,RC03257 ko00000,ko00001,ko00002,ko01000,ko02000,ko03009 3.A.1.29 iEC55989_1330.EC55989_1304,iLJ478.TM1383,iYO844.BSU00460 Bacteria 233J2@1762,2GKXD@201174,COG1947@1,COG1947@2 NA|NA|NA F Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol OLIIENHM_03088 1440774.Y900_007935 2.3e-138 498.4 Mycobacteriaceae ksgA GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 ko:K02528 R10716 RC00003,RC03257 ko00000,ko01000,ko03009 Bacteria 232YK@1762,2GKBT@201174,COG0030@1,COG0030@2 NA|NA|NA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits OLIIENHM_03089 931627.MycrhDRAFT_0702 2.7e-149 535.0 Mycobacteriaceae yabE GO:0005575,GO:0005576,GO:0008150,GO:0009892,GO:0009893,GO:0010468,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019222,GO:0022611,GO:0032502,GO:0040008,GO:0040009,GO:0040010,GO:0044111,GO:0044114,GO:0044115,GO:0044403,GO:0044419,GO:0045927,GO:0048518,GO:0048519,GO:0050789,GO:0051704,GO:0060255,GO:0065007,GO:0085016 ko:K21688 ko00000 Bacteria 235V0@1762,2H4RU@201174,COG3583@1,COG3583@2 NA|NA|NA L Resuscitation-promoting factor rpfB OLIIENHM_03090 1078020.KEK_03271 1.7e-122 445.7 Mycobacteriaceae tatD GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575 ko:K03424 ko00000,ko01000 Bacteria 233DI@1762,2GMJJ@201174,COG0084@1,COG0084@2 NA|NA|NA L TatD family OLIIENHM_03091 525368.HMPREF0591_4929 9.7e-246 855.9 Mycobacteriaceae metG GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 23347@1762,2GK4S@201174,COG0143@1,COG0143@2 NA|NA|NA J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation OLIIENHM_03092 875328.JDM601_0958 4e-168 597.8 Mycobacteriaceae pabB 2.6.1.85,4.1.3.38,5.4.4.2 ko:K01665,ko:K02361,ko:K02552,ko:K03342,ko:K13950 ko00130,ko00790,ko01053,ko01100,ko01110,ko01130,map00130,map00790,map01053,map01100,map01110,map01130 M00116 R01716,R01717,R05553 RC00010,RC00588,RC01418,RC01843,RC02148 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 235DI@1762,2I463@201174,COG1169@1,COG1169@2 NA|NA|NA HQ synthase component I OLIIENHM_03093 1440774.Y900_007970 1.8e-119 435.6 Mycobacteriaceae rsmI GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.198 ko:K07056 ko00000,ko01000,ko03009 Bacteria 234NJ@1762,2GJ9Q@201174,COG0313@1,COG0313@2 NA|NA|NA H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA OLIIENHM_03094 931627.MycrhDRAFT_0695 1.6e-256 891.7 Mycobacteriaceae pmt GO:0000030,GO:0003674,GO:0003824,GO:0006464,GO:0006486,GO:0006493,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0019538,GO:0034645,GO:0035268,GO:0035269,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0070085,GO:0071704,GO:0097502,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.4.1.109 ko:K00728 ko00514,ko00515,ko01100,map00514,map00515,map01100 R04072,R07620,R11399 RC00005,RC00059,RC00397 ko00000,ko00001,ko01000,ko01003 GT39 Bacteria 2338D@1762,2GITT@201174,COG4346@1,COG4346@2 NA|NA|NA O Dolichyl-phosphate-mannose--protein O-mannosyl transferase OLIIENHM_03095 1341646.CBMO010000118_gene1863 1.3e-10 72.0 Mycobacteriaceae Bacteria 23C1C@1762,2B25D@1,2GYJJ@201174,31X7R@2 NA|NA|NA OLIIENHM_03096 931627.MycrhDRAFT_0690 3.8e-192 677.6 Mycobacteriaceae arcA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.5.3.6 ko:K01478 ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130 R00552 RC00177 ko00000,ko00001,ko01000 Bacteria 234KW@1762,2GJTR@201174,COG2235@1,COG2235@2 NA|NA|NA E Arginine OLIIENHM_03097 931627.MycrhDRAFT_0688 5.7e-90 337.0 Mycobacteriaceae Bacteria 233H3@1762,2GNBD@201174,COG3145@1,COG3145@2 NA|NA|NA L DNA repair protein OLIIENHM_03098 1440774.Y900_008025 1e-76 293.1 Mycobacteriaceae Bacteria 235E1@1762,2AQ7W@1,2IBHN@201174,31FDQ@2 NA|NA|NA OLIIENHM_03099 931627.MycrhDRAFT_0686 4.7e-54 217.6 Mycobacteriaceae Bacteria 2394T@1762,2B9CD@1,2IKNX@201174,322Q3@2 NA|NA|NA OLIIENHM_03100 931627.MycrhDRAFT_0684 3.8e-60 237.7 Mycobacteriaceae tspO ko:K05770 ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166 ko00000,ko00001,ko02000 9.A.24 Bacteria 239U4@1762,2I3NJ@201174,COG3476@1,COG3476@2 NA|NA|NA T PFAM TspO MBR family OLIIENHM_03101 1341646.CBMO010000153_gene6420 6.1e-54 217.6 Mycobacteriaceae Bacteria 23CGI@1762,2FK6M@1,2H37E@201174,3200A@2 NA|NA|NA S Probable lipoprotein LpqN OLIIENHM_03102 1440774.Y900_008070 4.6e-135 487.6 Mycobacteriaceae mshD GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008080,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0017076,GO:0030551,GO:0030552,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 2.3.1.189 ko:K07001,ko:K09181,ko:K10914,ko:K15520 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 ko00000,ko00001,ko01000,ko03000 Bacteria 234EN@1762,2HNCU@201174,COG0664@1,COG0664@2,COG1670@1,COG1670@2 NA|NA|NA JT cyclic nucleotide-binding OLIIENHM_03103 931627.MycrhDRAFT_0677 4.3e-125 454.5 Mycobacteriaceae srsC Bacteria 234A4@1762,2GM2M@201174,COG0644@1,COG0644@2 NA|NA|NA C FAD dependent oxidoreductase OLIIENHM_03104 1440774.Y900_008090 3.7e-69 267.7 Mycobacteriaceae ypbQ ko:K16168 ko00000,ko01008 Bacteria 238M7@1762,2IG52@201174,COG1755@1,COG1755@2 NA|NA|NA S Isoprenylcysteine carboxyl methyltransferase OLIIENHM_03105 1440774.Y900_008095 5.2e-150 537.3 Mycobacteriaceae bcsA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006629,GO:0006725,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009273,GO:0009698,GO:0009699,GO:0009714,GO:0009715,GO:0009987,GO:0016020,GO:0016043,GO:0019438,GO:0019748,GO:0022607,GO:0032991,GO:0034081,GO:0042180,GO:0042181,GO:0042546,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0071554,GO:0071704,GO:0071766,GO:0071770,GO:0071840,GO:0071944,GO:1901360,GO:1901362,GO:1901576 ko:K16167 ko00000,ko01008 Bacteria 235DU@1762,2GV0U@201174,COG3424@1,COG3424@2 NA|NA|NA Q synthase OLIIENHM_03106 1440774.Y900_008105 6.2e-94 350.5 Bacteria yeeR GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.3.1.71,2.1.1.334 ko:K00223,ko:K21310 ko00100,ko00920,ko01100,ko01130,map00100,map00920,map01100,map01130 M00102 R05641,R11546 RC00237,RC02653 ko00000,ko00001,ko00002,ko01000 Bacteria COG2020@1,COG2020@2 NA|NA|NA O methyltransferase activity OLIIENHM_03107 1440774.Y900_008110 1.1e-104 386.3 Mycobacteriaceae 2.1.1.6 ko:K00545 ko00140,ko00350,ko00965,ko01100,ko04728,map00140,map00350,map00965,map01100,map04728 R02534,R02920,R03304,R04301,R04762,R04764,R04881,R04887 RC00003,RC00392 ko00000,ko00001,ko01000,ko04147 Bacteria 23382@1762,2GJYI@201174,COG4122@1,COG4122@2 NA|NA|NA S O-Methyltransferase OLIIENHM_03108 931627.MycrhDRAFT_0674 2.6e-284 984.6 Mycobacteriaceae ko:K06994 ko00000 Bacteria 233TR@1762,2GJ5A@201174,COG2409@1,COG2409@2 NA|NA|NA S MmpL family OLIIENHM_03109 258052.JNYV01000001_gene27 1.6e-66 260.4 Actinobacteria 1.4.3.4 ko:K00274 ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034 M00135 R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354 RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713 ko00000,ko00001,ko00002,ko01000 Bacteria 2GK23@201174,COG1231@1,COG1231@2 NA|NA|NA E (mono)amine oxidase OLIIENHM_03110 1440774.Y900_008115 2.2e-82 312.8 Mycobacteriaceae Bacteria 236CX@1762,2GP71@201174,COG0406@1,COG0406@2 NA|NA|NA G Phosphoglycerate mutase family OLIIENHM_03111 1299327.I546_3965 0.0 1360.9 Mycobacteriaceae glgP 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 R02111 ko00000,ko00001,ko01000 GT35 Bacteria 2337J@1762,2GIVZ@201174,COG0058@1,COG0058@2 NA|NA|NA G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties OLIIENHM_03112 350058.Mvan_3069 0.0 1466.8 Mycobacteriaceae xfp 4.1.2.22,4.1.2.9 ko:K01621 ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120 R00761,R01621 RC00032,RC00226 ko00000,ko00001,ko01000 Bacteria 23506@1762,2GN27@201174,COG3957@1,COG3957@2 NA|NA|NA G Phosphoketolase OLIIENHM_03115 931627.MycrhDRAFT_4329 1.2e-156 559.3 Mycobacteriaceae proA GO:0003674,GO:0003824,GO:0004350,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016620,GO:0016903,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 iLJ478.TM0293,iNJ661.Rv2427c,iYO844.BSU13130 Bacteria 232ZC@1762,2GISA@201174,COG0014@1,COG0014@2 NA|NA|NA E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate OLIIENHM_03116 931627.MycrhDRAFT_4328 5e-146 523.9 Mycobacteriaceae clpL Bacteria 232A5@1762,2GMM2@201174,COG0714@1,COG0714@2 NA|NA|NA S associated with various cellular activities OLIIENHM_03117 931627.MycrhDRAFT_4327 5.5e-243 846.7 Mycobacteriaceae ko:K07161 ko00000 Bacteria 232EY@1762,2GNTS@201174,COG3552@1,COG3552@2 NA|NA|NA S Protein containing von Willebrand factor type A (VWA) domain OLIIENHM_03118 1150599.MPHLEI_23024 4.2e-88 330.9 Mycobacteriaceae nadD GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18,3.6.1.55 ko:K00969,ko:K03574 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 Bacteria 232D4@1762,2GMFZ@201174,COG1057@1,COG1057@2 NA|NA|NA H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) OLIIENHM_03119 1150599.MPHLEI_23019 4.4e-51 207.2 Mycobacteriaceae rsfS GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113 2.7.7.18 ko:K00969,ko:K09710 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000,ko03009 Bacteria 2396R@1762,2IKZ3@201174,COG0799@1,COG0799@2 NA|NA|NA S Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation OLIIENHM_03120 1380386.JIAW01000002_gene5920 5e-106 390.6 Mycobacteriaceae gpmB GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0044237 3.1.3.73,3.1.3.85 ko:K02226,ko:K22306 ko00860,ko01100,map00860,map01100 M00122 R04594,R11173 RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 234DP@1762,2GJYU@201174,COG0406@1,COG0406@2 NA|NA|NA G Belongs to the phosphoglycerate mutase family OLIIENHM_03121 164757.Mjls_3532 2.1e-121 441.8 Mycobacteriaceae octT GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008374,GO:0009987,GO:0016020,GO:0016043,GO:0016414,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0022607,GO:0040007,GO:0043933,GO:0044085,GO:0044464,GO:0051259,GO:0051262,GO:0065003,GO:0071840,GO:0071944 Bacteria 234B2@1762,2GR6W@201174,COG2755@1,COG2755@2 NA|NA|NA E Sugar octanoyltransferase likely involved in the biosynthesis of mycobacterial methylglucose lipopolysaccharide (MGLP). Catalyzes the transfer of an octanoyl group from octanoyl- CoA to the C6 OH of the second glucose in diglucosylglycerate (DGG) OLIIENHM_03122 931627.MycrhDRAFT_4320 1.4e-102 379.4 Mycobacteriaceae GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 232BT@1762,2GIUV@201174,COG1307@1,COG1307@2 NA|NA|NA S DegV family OLIIENHM_03123 710685.MycrhN_4235 6.8e-182 643.3 Mycobacteriaceae dapB_2 1.17.1.8,1.4.1.12,1.4.1.26 ko:K00215,ko:K21672 ko00261,ko00300,ko00310,ko00330,ko00472,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map00310,map00330,map00472,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R02825,R04198,R04199,R04200,R04201,R04687,R04688 RC00249,RC00478,RC00790 ko00000,ko00001,ko00002,ko01000 Bacteria 2352B@1762,2I8CX@201174,COG3804@1,COG3804@2 NA|NA|NA S dihydrodipicolinate reductase OLIIENHM_03124 1440774.Y900_022175 4.2e-80 304.7 Mycobacteriaceae comEA ko:K02237 M00429 ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 Bacteria 234VK@1762,2IQDC@201174,COG1555@1,COG1555@2 NA|NA|NA L TIGRFAM Competence protein ComEA, helix-hairpin-helix OLIIENHM_03125 931627.MycrhDRAFT_4316 5.3e-164 584.3 Mycobacteriaceae comE ko:K02238 M00429 ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 Bacteria 232XU@1762,2GJGR@201174,COG0658@1,COG0658@2 NA|NA|NA S ComEC Rec2-related protein OLIIENHM_03126 931627.MycrhDRAFT_4315 1.4e-130 472.6 Mycobacteriaceae holA 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 2343G@1762,2GNMZ@201174,COG1466@1,COG1466@2 NA|NA|NA L DNA polymerase III, delta OLIIENHM_03127 1440774.Y900_022190 4.1e-32 143.7 Mycobacteriaceae rpsT GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030234,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0042979,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050790,GO:0065003,GO:0065007,GO:0065009,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02968 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 23AKW@1762,2IQ73@201174,COG0268@1,COG0268@2 NA|NA|NA J Binds directly to 16S ribosomal RNA OLIIENHM_03128 931627.MycrhDRAFT_4313 6.3e-245 853.2 Mycobacteriaceae gcs2 Bacteria 232QP@1762,2GN0J@201174,COG2308@1,COG2308@2 NA|NA|NA S Circularly permuted ATP-grasp type 2 OLIIENHM_03129 931627.MycrhDRAFT_4312 2e-148 531.9 Mycobacteriaceae MA20_32425 Bacteria 234N2@1762,2GN0T@201174,COG2307@1,COG2307@2 NA|NA|NA S A predicted alpha-helical domain with a conserved ER motif. OLIIENHM_03130 1440774.Y900_022205 2.1e-130 471.9 Mycobacteriaceae Bacteria 232WC@1762,2GN5D@201174,COG1305@1,COG1305@2 NA|NA|NA E transglutaminase-like OLIIENHM_03131 1440774.Y900_022215 1e-129 469.5 Mycobacteriaceae rnz 3.1.26.11 ko:K00784 ko03013,map03013 ko00000,ko00001,ko01000,ko03016 Bacteria 232BJ@1762,2HV83@201174,COG1234@1,COG1234@2 NA|NA|NA S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA OLIIENHM_03132 1440774.Y900_022240 1.2e-55 222.6 Mycobacteriaceae Bacteria 23F9T@1762,2I3M3@201174,COG2905@1,COG2905@2 NA|NA|NA T CBS domain OLIIENHM_03133 1440774.Y900_022245 2.4e-86 325.1 Mycobacteriaceae Bacteria 232IN@1762,2GM10@201174,COG2337@1,COG2337@2 NA|NA|NA T PemK-like, MazF-like toxin of type II toxin-antitoxin system OLIIENHM_03134 710685.MycrhN_3340 9.1e-64 250.0 Mycobacteriaceae moaB 4.2.1.96 ko:K01724 ko00790,map00790 R04734 RC01208 ko00000,ko00001,ko01000,ko04147 Bacteria 233MQ@1762,2IACJ@201174,COG0521@1,COG0521@2 NA|NA|NA H molybdenum cofactor OLIIENHM_03135 931627.MycrhDRAFT_0643 8.1e-146 523.9 Mycobacteriaceae pepD ko:K08372 ko02020,map02020 ko00000,ko00001,ko01000,ko01002 Bacteria 232J2@1762,2GJ96@201174,COG0265@1,COG0265@2 NA|NA|NA O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain OLIIENHM_03136 1440774.Y900_008245 6.1e-216 756.9 Mycobacteriaceae Bacteria 236PZ@1762,2GM17@201174,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor OLIIENHM_03137 1440774.Y900_008250 7e-116 423.3 Mycobacteriaceae Bacteria 233IU@1762,2GIZB@201174,COG0745@1,COG0745@2 NA|NA|NA K Member of the two-component regulatory system MprB MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a transcriptional regulator that recognizes a 19-bp nucleotide motif comprizing two loosely conserved 8-bp direct DNA-binding motif repeats separated by a 3-bp spacer region OLIIENHM_03138 246196.MSMEI_5337 5.9e-19 99.4 Mycobacteriaceae rpmF ko:K02911 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011,ko03029 Bacteria 23BC2@1762,2DRA3@1,2GQK2@201174,33AVR@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL32 family OLIIENHM_03139 1440774.Y900_002970 9e-218 762.7 Mycobacteriaceae infB GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 ko:K02519 ko00000,ko03012,ko03029 Bacteria 233NE@1762,2I4HP@201174,COG0481@1,COG0481@2 NA|NA|NA J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex OLIIENHM_03140 1298864.AUEQ01000002_gene6027 1e-63 249.6 Mycobacteriaceae rbfA ko:K02834 ko00000,ko03009 Bacteria 238QC@1762,2IKXP@201174,COG0858@1,COG0858@2 NA|NA|NA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA OLIIENHM_03141 931627.MycrhDRAFT_6398 9.4e-117 426.8 Mycobacteriaceae nrnA GO:0008150,GO:0040007 2.7.7.72,3.1.13.3,3.1.3.7 ko:K00974,ko:K06881 ko00920,ko01100,ko01120,ko03013,map00920,map01100,map01120,map03013 R00188,R00508,R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016,ko03400 Bacteria 233C9@1762,2GN9Z@201174,COG0618@1,COG0618@2 NA|NA|NA J Phosphoesterase OLIIENHM_03142 1120797.KB908255_gene778 1.3e-171 609.4 Mycobacteriaceae dinF GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03327 ko00000,ko02000 2.A.66.1 Bacteria 232HM@1762,2GJE3@201174,COG0534@1,COG0534@2 NA|NA|NA V Efflux protein, MATE family OLIIENHM_03143 1440774.Y900_002950 1.1e-114 419.5 Mycobacteriaceae echA16 GO:0003674,GO:0003824,GO:0004300,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 Bacteria 2336T@1762,2GN69@201174,COG1024@1,COG1024@2 NA|NA|NA I Enoyl-CoA hydratase OLIIENHM_03145 1440774.Y900_002920 6.3e-208 730.3 Mycobacteriaceae ko:K06978 ko00000 Bacteria 235FX@1762,2GK8B@201174,COG2936@1,COG2936@2 NA|NA|NA S Hydrolase OLIIENHM_03146 1440774.Y900_002915 7.3e-172 609.8 Mycobacteriaceae Bacteria 232TK@1762,2GKMR@201174,COG1409@1,COG1409@2 NA|NA|NA S Metallophosphoesterase OLIIENHM_03147 1440774.Y900_002910 1.8e-103 382.1 Mycobacteriaceae pptA Bacteria 2334V@1762,2IIA2@201174,COG2977@1,COG2977@2 NA|NA|NA Q Belongs to the P-Pant transferase superfamily OLIIENHM_03148 1440774.Y900_002905 3.9e-125 454.5 Mycobacteriaceae truB GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 ko:K03177 ko00000,ko01000,ko03016 Bacteria 2347A@1762,2GJZK@201174,COG0130@1,COG0130@2 NA|NA|NA J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs OLIIENHM_03149 350058.Mvan_2330 1.2e-38 166.0 Mycobacteriaceae 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 Bacteria 23A8P@1762,2I5GC@201174,COG2524@1,COG2524@2 NA|NA|NA K but domain identity suggests it may be a signal-transduction protein OLIIENHM_03150 931627.MycrhDRAFT_6412 1.4e-163 582.4 Mycobacteriaceae ribF GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008531,GO:0009058,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009124,GO:0009156,GO:0009161,GO:0009165,GO:0009231,GO:0009259,GO:0009260,GO:0009398,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0034654,GO:0042364,GO:0042726,GO:0042727,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046390,GO:0046444,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 2335U@1762,2GKQF@201174,COG0196@1,COG0196@2 NA|NA|NA H Belongs to the ribF family OLIIENHM_03151 1209984.BN978_04972 7.2e-40 169.5 Mycobacteriaceae rpsO GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006378,GO:0006396,GO:0006397,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016071,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031123,GO:0031124,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043631,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02956 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 239X2@1762,2IQA0@201174,COG0184@1,COG0184@2 NA|NA|NA J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome OLIIENHM_03152 931627.MycrhDRAFT_6416 0.0 1310.8 Mycobacteriaceae pnp GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 Bacteria 235BM@1762,2GIT2@201174,COG1185@1,COG1185@2 NA|NA|NA J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction OLIIENHM_03153 1440774.Y900_002870 1.4e-200 705.7 Mycobacteriaceae pepR GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 233RW@1762,2GJZ3@201174,COG0612@1,COG0612@2 NA|NA|NA S Belongs to the peptidase M16 family OLIIENHM_03155 931627.MycrhDRAFT_6422 7.3e-187 659.8 Mycobacteriaceae ald GO:0000286,GO:0001666,GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009628,GO:0009987,GO:0016020,GO:0016054,GO:0016491,GO:0016638,GO:0019752,GO:0030312,GO:0036293,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0050896,GO:0055114,GO:0070482,GO:0071704,GO:0071944,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 R00396 RC00008 ko00000,ko00001,ko01000 Bacteria 232CE@1762,2GJ6G@201174,COG0686@1,COG0686@2 NA|NA|NA C Belongs to the AlaDH PNT family OLIIENHM_03156 710686.Mycsm_02501 2.3e-71 275.0 Mycobacteriaceae Bacteria 235ZA@1762,2GMSR@201174,COG1522@1,COG1522@2 NA|NA|NA K AsnC family OLIIENHM_03157 1440774.Y900_002840 4.6e-113 414.1 Mycobacteriaceae dapB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0055114,GO:0070402,GO:0070404,GO:0071704,GO:0071944,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 iJN678.dapB,iNJ661.Rv2773c,iYO844.BSU22490 Bacteria 23462@1762,2GM2T@201174,COG0289@1,COG0289@2 NA|NA|NA E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate OLIIENHM_03158 1440774.Y900_002835 2.4e-51 208.4 Mycobacteriaceae Bacteria 238SC@1762,2IFHE@201174,COG5010@1,COG5010@2 NA|NA|NA U COG0457 FOG TPR repeat OLIIENHM_03159 216594.MMAR_1941 2.8e-68 264.6 Mycobacteriaceae fldA Bacteria 238PS@1762,2II43@201174,COG0655@1,COG0655@2 NA|NA|NA S Multimeric flavodoxin WrbA OLIIENHM_03161 931627.MycrhDRAFT_6431 2.4e-36 158.3 Mycobacteriaceae Bacteria 239AA@1762,2ATBA@1,2IIEE@201174,31IUB@2 NA|NA|NA OLIIENHM_03162 1380386.JIAW01000002_gene5615 8.2e-102 376.7 Mycobacteriaceae 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 Bacteria 232E2@1762,2GJMH@201174,COG0412@1,COG0412@2 NA|NA|NA Q dienelactone hydrolase OLIIENHM_03163 1341646.CBMO010000115_gene2181 5.6e-17 93.6 Mycobacteriaceae Bacteria 23B61@1762,2EPYK@1,2GRIQ@201174,33HJ6@2 NA|NA|NA OLIIENHM_03164 931627.MycrhDRAFT_3729 2.4e-145 521.5 Mycobacteriaceae mca GO:0003674,GO:0005488,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009636,GO:0009987,GO:0010126,GO:0010127,GO:0016137,GO:0042221,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050896,GO:0051186,GO:0071704,GO:0098754,GO:1901135,GO:1901657 3.5.1.115 ko:K18455 ko00000,ko01000 Bacteria 234NY@1762,2H2NY@201174,COG2120@1,COG2120@2 NA|NA|NA S A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics OLIIENHM_03165 1440774.Y900_018745 5.8e-43 180.3 Mycobacteriaceae Bacteria 239HK@1762,2DRBP@1,2IGPY@201174,33B4I@2 NA|NA|NA S Domain of unknown function (DUF4307) OLIIENHM_03166 164757.Mjls_4375 6.7e-76 290.0 Mycobacteriaceae greA GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006354,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0030312,GO:0031323,GO:0031326,GO:0032774,GO:0032784,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 ko:K03624 ko00000,ko03021 Bacteria 233YD@1762,2GNZV@201174,COG0782@1,COG0782@2 NA|NA|NA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides OLIIENHM_03167 931627.MycrhDRAFT_3726 4.2e-65 254.6 Mycobacteriaceae Bacteria 2336E@1762,2CF3N@1,2GIUD@201174,2ZYXY@2 NA|NA|NA S Golgi phosphoprotein 3 (GPP34) OLIIENHM_03168 931627.MycrhDRAFT_3725 2.7e-184 651.4 Mycobacteriaceae metB GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009092,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0017144,GO:0019279,GO:0019343,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071265,GO:0071266,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.48,4.4.1.1,4.4.1.8 ko:K01739,ko:K01758,ko:K01760 ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017,M00338 R00782,R00999,R01001,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04941,R04944,R04945,R04946,R09366 RC00020,RC00056,RC00069,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000,ko04147 iNJ661.Rv1079 Bacteria 232HB@1762,2GJ5S@201174,COG0626@1,COG0626@2 NA|NA|NA E cystathionine OLIIENHM_03169 164757.Mjls_4379 6.9e-56 224.6 Mycobacteriaceae VP1530 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 234B0@1762,2GN5K@201174,COG5473@1,COG5473@2 NA|NA|NA J Zn-ribbon protein possibly nucleic acid-binding OLIIENHM_03170 1440774.Y900_018725 3.3e-45 188.3 Mycobacteriaceae Bacteria 232GQ@1762,2HGSH@201174,COG1714@1,COG1714@2 NA|NA|NA S pfam rdd OLIIENHM_03171 1440774.Y900_018715 2.3e-238 831.2 Mycobacteriaceae cbs GO:0003674,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008144,GO:0016020,GO:0019842,GO:0030170,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0071944,GO:0097159,GO:1901363 2.5.1.47,4.2.1.22 ko:K01697,ko:K01738 ko00260,ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021,M00035,M00338 R00891,R00897,R01290,R03601,R04859,R04942 RC00020,RC00056,RC00069,RC00256,RC00489,RC01246,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 Bacteria 233SJ@1762,2GIXE@201174,COG0031@1,COG0031@2,COG3620@1,COG3620@2 NA|NA|NA EK Cystathionine beta-synthase OLIIENHM_03172 1440774.Y900_018710 9.8e-170 602.8 Mycobacteriaceae lipU GO:0003674,GO:0003824,GO:0004620,GO:0004629,GO:0008081,GO:0008150,GO:0009268,GO:0009605,GO:0009607,GO:0009628,GO:0010447,GO:0016298,GO:0016787,GO:0016788,GO:0040007,GO:0042578,GO:0043207,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0052689,GO:0075136 Bacteria 232JC@1762,2GKCQ@201174,COG0657@1,COG0657@2 NA|NA|NA I Alpha beta hydrolase OLIIENHM_03173 1440774.Y900_018705 3.4e-121 441.4 Mycobacteriaceae Bacteria 232GH@1762,2GMVS@201174,COG2755@1,COG2755@2 NA|NA|NA E GDSL-like Lipase/Acylhydrolase family OLIIENHM_03174 931627.MycrhDRAFT_4115 4.9e-53 214.5 Bacteria 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 R03940 RC00026,RC00165 ko00000,ko00001,ko01000 Bacteria COG1247@1,COG1247@2 NA|NA|NA M phosphinothricin N-acetyltransferase activity OLIIENHM_03175 931627.MycrhDRAFT_2204 0.0 1222.2 Mycobacteriaceae ko:K06994 ko00000 Bacteria 232PC@1762,2GKX6@201174,COG2409@1,COG2409@2 NA|NA|NA S transport protein OLIIENHM_03176 931627.MycrhDRAFT_2203 5.5e-39 167.2 Mycobacteriaceae Bacteria 238MH@1762,2BG05@1,2IGFG@201174,329UM@2 NA|NA|NA S Mycobacterium membrane protein OLIIENHM_03177 1440774.Y900_012810 0.0 1340.5 Mycobacteriaceae ko:K06994 ko00000 Bacteria 232PC@1762,2GKX6@201174,COG2409@1,COG2409@2 NA|NA|NA S transport protein OLIIENHM_03178 216594.MMAR_1696 8.4e-46 189.9 Mycobacteriaceae Bacteria 238MH@1762,2BG05@1,2IGFG@201174,329UM@2 NA|NA|NA S Mycobacterium membrane protein OLIIENHM_03179 710687.KI912270_gene2277 6e-65 253.8 Mycobacteriaceae GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141 Bacteria 236S0@1762,2GJHD@201174,COG1309@1,COG1309@2 NA|NA|NA K Transcriptional regulator OLIIENHM_03181 1313172.YM304_05600 2.5e-39 168.7 Bacteria Bacteria COG1309@1,COG1309@2 NA|NA|NA K transcriptional regulator OLIIENHM_03182 931627.MycrhDRAFT_1131 0.0 1153.7 Mycobacteriaceae uvrD2 GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0006996,GO:0008094,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0040007,GO:0042623,GO:0043167,GO:0043169,GO:0046872,GO:0051276,GO:0071103,GO:0071840,GO:0140097 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 232S6@1762,2GKRW@201174,COG0210@1,COG0210@2 NA|NA|NA L DNA helicase OLIIENHM_03183 931627.MycrhDRAFT_1130 6.2e-29 132.9 Mycobacteriaceae grxA 1.20.4.3 ko:K18917 ko00000,ko01000 Bacteria 23AKM@1762,2IQF9@201174,COG0695@1,COG0695@2 NA|NA|NA O Glutaredoxin OLIIENHM_03184 262316.MAP_0994 1.1e-19 102.8 Mycobacteriaceae Bacteria 23BFB@1762,2B3M3@1,2IQ45@201174,31WAF@2 NA|NA|NA OLIIENHM_03185 1440774.Y900_006095 5.9e-134 483.8 Mycobacteriaceae nudC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.1.22 ko:K03426 ko00760,ko01100,ko04146,map00760,map01100,map04146 R00103,R03004,R11104 RC00002 ko00000,ko00001,ko01000 Bacteria 232IT@1762,2GJZY@201174,COG2816@1,COG2816@2 NA|NA|NA L NADH pyrophosphatase OLIIENHM_03186 1440774.Y900_006100 3.2e-155 554.7 Mycobacteriaceae kch 3.6.1.22 ko:K03426,ko:K10716 ko00760,ko01100,ko04146,map00760,map01100,map04146 R00103,R03004,R11104 RC00002 ko00000,ko00001,ko01000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 Bacteria 2344T@1762,2GKB8@201174,COG1226@1,COG1226@2 NA|NA|NA P transport OLIIENHM_03187 931627.MycrhDRAFT_1125 2e-46 191.8 Mycobacteriaceae Bacteria 239CM@1762,2IQJ5@201174,COG4270@1,COG4270@2 NA|NA|NA S membrane OLIIENHM_03188 258533.BN977_01936 8e-60 236.5 Mycobacteriaceae MA20_39615 ko:K09705 ko00000 Bacteria 238MX@1762,2IFG5@201174,COG3542@1,COG3542@2 NA|NA|NA S Cupin superfamily (DUF985) OLIIENHM_03189 1440774.Y900_006110 0.0 1517.3 Mycobacteriaceae uvrD2 3.6.4.12 ko:K03657,ko:K07465 ko03420,ko03430,map03420,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 233NR@1762,2GM2E@201174,COG0210@1,COG0210@2,COG2887@1,COG2887@2 NA|NA|NA L Belongs to the helicase family. UvrD subfamily OLIIENHM_03190 931627.MycrhDRAFT_1123 0.0 1413.7 Mycobacteriaceae uvrD 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 234NM@1762,2GJD0@201174,COG0210@1,COG0210@2,COG2887@1,COG2887@2 NA|NA|NA L Belongs to the helicase family. UvrD subfamily OLIIENHM_03191 931627.MycrhDRAFT_6644 6.9e-165 587.4 Mycobacteriaceae cydC ko:K16012 ko02010,map02010 ko00000,ko00001,ko02000 3.A.1.129 Bacteria 234Q2@1762,2GITR@201174,COG1132@1,COG1132@2 NA|NA|NA V ABC transporter OLIIENHM_03192 931627.MycrhDRAFT_6645 2.9e-176 625.2 Mycobacteriaceae cydD ko:K02068,ko:K16013 ko02010,map02010 M00211 ko00000,ko00001,ko00002,ko02000 3.A.1.129 Bacteria 2335R@1762,2I2DP@201174,COG4988@1,COG4988@2 NA|NA|NA V ABC transporter OLIIENHM_03193 1440774.Y900_023845 7.2e-144 516.9 Mycobacteriaceae cydB GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0016682,GO:0019646,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0070069,GO:0071944,GO:0097159,GO:1901363 1.10.3.14 ko:K00426 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 iECABU_c1320.ECABU_c10120,iLF82_1304.LF82_0101,iNRG857_1313.NRG857_04455,iPC815.YPO1118,ic_1306.c1120 Bacteria 234SG@1762,2GMFV@201174,COG1294@1,COG1294@2 NA|NA|NA C cytochrome D ubiquinol oxidase subunit II OLIIENHM_03194 931627.MycrhDRAFT_6647 8.2e-231 806.2 Mycobacteriaceae cydA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0016682,GO:0019646,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0070069,GO:0071944,GO:0097159,GO:1901363 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 iPC815.YPO1117,iSBO_1134.SBO_2253,iSFxv_1172.SFxv_0621,iS_1188.S0577,iSbBS512_1146.SbBS512_E2337 Bacteria 234HV@1762,2GJE4@201174,COG1271@1,COG1271@2 NA|NA|NA C ubiquinol oxidase (Subunit I) OLIIENHM_03195 350058.Mvan_4121 7.1e-216 756.5 Mycobacteriaceae ko:K07576 ko00000 Bacteria 232AU@1762,2HEXB@201174,COG1236@1,COG1236@2 NA|NA|NA J exonuclease of the beta-lactamase fold involved in RNA processing OLIIENHM_03196 1440774.Y900_006120 9.9e-106 389.8 Mycobacteriaceae lipV GO:0003674,GO:0003824,GO:0005488,GO:0005504,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008289,GO:0009056,GO:0009062,GO:0009268,GO:0009628,GO:0009987,GO:0010447,GO:0016042,GO:0016054,GO:0016298,GO:0016787,GO:0016788,GO:0019752,GO:0031406,GO:0032787,GO:0033293,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0050896,GO:0051716,GO:0071214,GO:0071467,GO:0071468,GO:0071704,GO:0072329,GO:0104004,GO:1901575 ko:K19311 ko00000,ko01000 Bacteria 236PV@1762,2I8EU@201174,COG0596@1,COG0596@2 NA|NA|NA S Alpha beta hydrolase OLIIENHM_03197 44454.NF84_19020 4e-39 167.2 Mycobacteriaceae ybaZ GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0005488,GO:0005515,GO:0019899,GO:0097159,GO:1901363 2.1.1.63 ko:K00567,ko:K07443 ko00000,ko01000,ko03400 Bacteria 239W1@1762,2GQMD@201174,COG3695@1,COG3695@2 NA|NA|NA L methylated DNA-protein cysteine methyltransferase OLIIENHM_03198 1120797.KB908260_gene4028 2.3e-129 468.4 Mycobacteriaceae Bacteria 232MX@1762,2HCIQ@201174,COG2334@1,COG2334@2 NA|NA|NA S Aminoglycoside phosphotransferase OLIIENHM_03199 710421.Mycch_1412 8.3e-165 586.6 Mycobacteriaceae moeB GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008146,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0016782,GO:0019344,GO:0019752,GO:0020012,GO:0030312,GO:0030682,GO:0042783,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071704,GO:0071944,GO:0075136,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.80,2.8.1.11,3.1.2.6 ko:K01069,ko:K21029,ko:K21147 ko00620,ko04122,map00620,map04122 R01736,R07459,R07461 RC00004,RC00043,RC00137 ko00000,ko00001,ko01000 Bacteria 233RR@1762,2GJB6@201174,COG0476@1,COG0476@2,COG0607@1,COG0607@2 NA|NA|NA HP The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are OLIIENHM_03200 1440774.Y900_006140 9.8e-159 566.2 Mycobacteriaceae Bacteria 232G0@1762,2GMJR@201174,COG5479@1,COG5479@2 NA|NA|NA M Zinc-dependent metalloprotease OLIIENHM_03201 258533.BN977_05057 7.3e-99 366.7 Mycobacteriaceae Bacteria 232DA@1762,2GVM5@201174,COG1309@1,COG1309@2 NA|NA|NA K tetR family OLIIENHM_03202 931627.MycrhDRAFT_1116 6.4e-22 110.2 Mycobacteriaceae Bacteria 23AM7@1762,2E3M2@1,2GQQW@201174,32YJA@2 NA|NA|NA S Protein of unknown function (DUF3107) OLIIENHM_03203 1440774.Y900_006155 2.7e-36 158.7 Mycobacteriaceae Bacteria 232AV@1762,2A3D5@1,2IGPP@201174,31HEM@2 NA|NA|NA OLIIENHM_03204 931627.MycrhDRAFT_1114 3.9e-89 334.3 Mycobacteriaceae 1.14.13.149,1.14.13.227,1.14.13.236,4.1.99.5 ko:K02611,ko:K14331,ko:K15760,ko:K18223 ko00360,ko00623,ko00640,ko01100,ko01120,ko01220,map00360,map00623,map00640,map01100,map01120,map01220 M00538 R02550,R03562,R05666,R09838,R10702 RC00269,RC00490,RC02690,RC03249 ko00000,ko00001,ko00002,ko01000 Bacteria 234AK@1762,2GKXZ@201174,COG3396@1,COG3396@2 NA|NA|NA S Hydroxylase for synthesis of 2-methylthio-cis-ribozeatin in tRNA OLIIENHM_03205 931627.MycrhDRAFT_1113 1.6e-216 758.8 Mycobacteriaceae deaD 3.6.4.13 ko:K05592,ko:K11927 ko03018,map03018 ko00000,ko00001,ko01000,ko03009,ko03019 Bacteria 232M9@1762,2GIUR@201174,COG0513@1,COG0513@2 NA|NA|NA L Belongs to the DEAD box helicase family OLIIENHM_03206 1440774.Y900_006170 9.9e-153 546.6 Mycobacteriaceae Bacteria 23F5S@1762,2I2M6@201174,COG1376@1,COG1376@2 NA|NA|NA S ErfK ybiS ycfS ynhG family protein OLIIENHM_03207 931627.MycrhDRAFT_1111 9.3e-123 446.4 Mycobacteriaceae soj ko:K03496 ko00000,ko03036,ko04812 Bacteria 232PP@1762,2GNEQ@201174,COG1192@1,COG1192@2 NA|NA|NA D chromosome partitioning OLIIENHM_03208 931627.MycrhDRAFT_1110 4e-91 340.9 Mycobacteriaceae gpm2 GO:0003674,GO:0003824,GO:0003993,GO:0005488,GO:0005515,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0042802,GO:0042803,GO:0044237,GO:0046983 Bacteria 233UC@1762,2GNRS@201174,COG0406@1,COG0406@2 NA|NA|NA G phosphoglycerate mutase OLIIENHM_03209 1440774.Y900_006185 6.4e-135 487.3 Mycobacteriaceae entC 5.4.4.2 ko:K02361,ko:K02552 ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130 M00116 R01717 RC00588 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv3215 Bacteria 233YM@1762,2GKE8@201174,COG1169@1,COG1169@2 NA|NA|NA HQ Isochorismate synthase OLIIENHM_03210 931627.MycrhDRAFT_1108 3.6e-61 241.1 Mycobacteriaceae Bacteria 23F7U@1762,2IHSU@201174,COG1247@1,COG1247@2 NA|NA|NA M FR47-like protein OLIIENHM_03211 1223545.GS4_15_01010 5.7e-19 101.3 Gordoniaceae Bacteria 2IQG2@201174,4GACC@85026,COG3548@1,COG3548@2 NA|NA|NA S Protein of unknown function (DUF1211) OLIIENHM_03212 164757.Mjls_1419 1.1e-38 166.0 Mycobacteriaceae Bacteria 23F4D@1762,2DTKM@1,2IMNV@201174,33KSC@2 NA|NA|NA OLIIENHM_03213 557599.MKAN_21760 2e-13 82.8 Mycobacteriaceae lpqQ Bacteria 238FD@1762,2B2XV@1,2ID8J@201174,31VIN@2 NA|NA|NA S PknH-like extracellular domain OLIIENHM_03214 931627.MycrhDRAFT_1103 2.4e-133 481.9 Mycobacteriaceae Bacteria 23500@1762,2GJ3K@201174,COG1597@1,COG1597@2 NA|NA|NA I diacylglycerol kinase, catalytic OLIIENHM_03215 1298864.AUEQ01000001_gene4691 2.4e-34 151.0 Mycobacteriaceae whiB GO:0000302,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0015035,GO:0015036,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042221,GO:0042493,GO:0045892,GO:0045934,GO:0047134,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0060255,GO:0065007,GO:0071731,GO:0080090,GO:0097159,GO:0097366,GO:1901363,GO:1901698,GO:1901700,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 ko:K18955 ko00000,ko03000 Bacteria 239ZR@1762,2DMIE@1,2IQCG@201174,32RSG@2 NA|NA|NA K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA OLIIENHM_03216 1078020.KEK_11823 3.1e-27 127.1 Mycobacteriaceae rpsS GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02965 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 239XX@1762,2IKMS@201174,COG0185@1,COG0185@2 NA|NA|NA J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA OLIIENHM_03217 1440774.Y900_018155 9.8e-152 542.7 Mycobacteriaceae rplB GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02886 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 235ZI@1762,2GK7R@201174,COG0090@1,COG0090@2 NA|NA|NA J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity OLIIENHM_03218 258533.BN977_04561 9.9e-46 189.1 Mycobacteriaceae rplW GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02892 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 23A1N@1762,2IQ7V@201174,COG0089@1,COG0089@2 NA|NA|NA J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome OLIIENHM_03219 1150599.MPHLEI_04927 1.5e-99 369.0 Mycobacteriaceae rplD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02926 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 23474@1762,2GJYJ@201174,COG0088@1,COG0088@2 NA|NA|NA J 50S ribosomal protein L4 OLIIENHM_03220 931627.MycrhDRAFT_3539 1.7e-98 365.5 Mycobacteriaceae rplC GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010604,GO:0010628,GO:0015934,GO:0016020,GO:0016043,GO:0019219,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0031323,GO:0031325,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000232,GO:2000234 ko:K02906 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 234PZ@1762,2GJXT@201174,COG0087@1,COG0087@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit OLIIENHM_03221 1068978.AMETH_0651 5.1e-50 203.4 Pseudonocardiales rpsJ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02946 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2IHRA@201174,4E3HD@85010,COG0051@1,COG0051@2 NA|NA|NA J Involved in the binding of tRNA to the ribosomes OLIIENHM_03222 1496688.ER33_03300 1.4e-78 301.2 Cyanobacteria 2.7.13.3 ko:K15011 ko02020,map02020 M00523 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 1G1PK@1117,COG3447@1,COG3447@2,COG3614@1,COG3614@2,COG4191@1,COG4191@2 NA|NA|NA T CHASE OLIIENHM_03223 1440774.Y900_018125 7.3e-171 606.7 Mycobacteriaceae 1.4.1.12,1.4.1.26 ko:K21672 ko00310,ko00330,ko00472,map00310,map00330,map00472 R02825,R04200,R04201,R04687,R04688 RC00249,RC00790 ko00000,ko00001,ko01000 Bacteria 2341J@1762,2GMU5@201174,COG3804@1,COG3804@2 NA|NA|NA S dihydrodipicolinate reductase OLIIENHM_03224 710685.MycrhN_4073 1.2e-67 264.6 Mycobacteriaceae 3.1.3.3 ko:K07315,ko:K20971 ko02025,map02025 ko00000,ko00001,ko01000,ko01001,ko02022,ko03021 Bacteria 23FCK@1762,2I43Y@201174,COG2208@1,COG2208@2,COG4251@1,COG4251@2 NA|NA|NA T GAF domain OLIIENHM_03225 1440774.Y900_018105 4.9e-189 667.5 Mycobacteriaceae ko:K03929 ko00000,ko01000 CE10 Bacteria 234ZR@1762,2GJCN@201174,COG2272@1,COG2272@2 NA|NA|NA I Belongs to the type-B carboxylesterase lipase family OLIIENHM_03226 1341646.CBMO010000093_gene5690 5.7e-284 983.0 Mycobacteriaceae betA 1.1.99.1 ko:K00108 ko00260,ko01100,map00260,map01100 M00555 R01025 RC00087 ko00000,ko00001,ko00002,ko01000 Bacteria 233HY@1762,2GJAU@201174,COG2303@1,COG2303@2 NA|NA|NA E Belongs to the GMC oxidoreductase family OLIIENHM_03227 1440774.Y900_018100 1.3e-195 689.1 Mycobacteriaceae Bacteria 23311@1762,2GKCG@201174,COG2124@1,COG2124@2 NA|NA|NA Q cytochrome p450 OLIIENHM_03228 1440774.Y900_018085 1.3e-95 356.7 Mycobacteriaceae 1.1.99.1 ko:K00108 ko00260,ko01100,map00260,map01100 M00555 R01025 RC00087 ko00000,ko00001,ko00002,ko01000 Bacteria 2339X@1762,2GJAU@201174,COG2303@1,COG2303@2 NA|NA|NA E Dehydrogenase OLIIENHM_03229 875328.JDM601_3961 9.8e-105 386.7 Mycobacteriaceae ponA 2.4.1.129,2.7.11.1,3.4.16.4 ko:K05365,ko:K05366,ko:K12132 ko00550,ko01100,ko01501,map00550,map01100,map01501 R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01001,ko01003,ko01011 GT51 Bacteria 234AV@1762,2GK21@201174,COG0744@1,COG0744@2,COG2815@1,COG2815@2 NA|NA|NA M penicillin-binding protein OLIIENHM_03231 931627.MycrhDRAFT_0093 8.7e-164 583.2 Mycobacteriaceae cysK 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 Bacteria 2342Y@1762,2GNE4@201174,COG0031@1,COG0031@2 NA|NA|NA E cysteine synthase OLIIENHM_03233 525368.HMPREF0591_4876 6.7e-198 696.8 Mycobacteriaceae Bacteria 233EN@1762,2HQSF@201174,COG2421@1,COG2421@2 NA|NA|NA C Acetamidase formamidase OLIIENHM_03234 44454.NF84_15835 5.5e-143 514.2 Mycobacteriaceae amiB ko:K01436 ko00000,ko01000,ko01002 Bacteria 234K6@1762,2GK05@201174,COG1473@1,COG1473@2 NA|NA|NA S Peptidase dimerisation domain OLIIENHM_03235 1286171.EAL2_808p06130 1.8e-73 282.7 Eubacteriaceae wcoO Bacteria 1V6UR@1239,24D2S@186801,25YY0@186806,COG1030@1,COG1030@2 NA|NA|NA OLIIENHM_03236 931627.MycrhDRAFT_0087 4.3e-284 983.4 Mycobacteriaceae MA20_22130 ko:K07077 ko00000 Bacteria 232XQ@1762,2GIYM@201174,COG3573@1,COG3573@2 NA|NA|NA S Dehydrogenase OLIIENHM_03237 931627.MycrhDRAFT_0085 2.5e-135 488.4 Mycobacteriaceae yhbH ko:K09786 ko00000 Bacteria 233F5@1762,2I2WH@201174,COG2718@1,COG2718@2 NA|NA|NA S Iron-containing redox enzyme OLIIENHM_03238 931627.MycrhDRAFT_0083 5.7e-70 270.8 Mycobacteriaceae prmC_1 2.1.1.297 ko:K02493 R10806 RC00003,RC03279 ko00000,ko01000,ko03012 Bacteria 236TB@1762,2IIBT@201174,COG2890@1,COG2890@2 NA|NA|NA J methylase OLIIENHM_03240 931627.MycrhDRAFT_0080 1.9e-64 251.9 Mycobacteriaceae yqeY ko:K09117 ko00000 Bacteria 238YP@1762,2IFFJ@201174,COG1610@1,COG1610@2 NA|NA|NA S Yqey-like protein OLIIENHM_03241 1440774.Y900_011240 1.3e-72 280.4 Mycobacteriaceae CP_0034 ko:K02417,ko:K02519 ko02030,ko02040,map02030,map02040 ko00000,ko00001,ko02035,ko02044,ko03012,ko03029 3.A.6.2,3.A.6.3 Bacteria 2330W@1762,2GKJ7@201174,COG5180@1,COG5180@2 NA|NA|NA A pathogenesis OLIIENHM_03242 710686.Mycsm_06005 9.5e-56 223.4 Mycobacteriaceae Bacteria 235TU@1762,2CT9V@1,2GKR6@201174,32SSX@2 NA|NA|NA S Domain of unknown function (DUF4129) OLIIENHM_03243 1440774.Y900_011250 3.8e-130 471.5 Mycobacteriaceae GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 23499@1762,29B69@1,2GKQW@201174,2ZY4N@2 NA|NA|NA OLIIENHM_03244 1440774.Y900_011255 1.4e-154 552.4 Mycobacteriaceae moxR2 ko:K03924 ko00000,ko01000 Bacteria 233MI@1762,2GK07@201174,COG0714@1,COG0714@2 NA|NA|NA S associated with various cellular activities OLIIENHM_03245 931627.MycrhDRAFT_0075 5.3e-184 650.6 Mycobacteriaceae Bacteria 232TV@1762,2GK9A@201174,COG1721@1,COG1721@2 NA|NA|NA S conserved protein (some members contain a von Willebrand factor type A (vWA) domain) OLIIENHM_03246 164757.Mjls_5230 3.3e-146 524.6 Mycobacteriaceae ko:K06384 ko00000 Bacteria 232KX@1762,2GJTG@201174,COG1300@1,COG1300@2 NA|NA|NA S membrane OLIIENHM_03247 1150599.MPHLEI_06872 2.7e-79 302.0 Mycobacteriaceae Bacteria 232TH@1762,2A3P3@1,2HFBF@201174,30S6I@2 NA|NA|NA S Mannan-binding protein OLIIENHM_03248 1150599.MPHLEI_06867 2.9e-58 231.9 Mycobacteriaceae ko:K18481 M00670 ko00000,ko00002,ko02000 3.A.1.27.4,3.A.1.27.5 Bacteria 239E2@1762,2E5H4@1,2IJ95@201174,3308M@2 NA|NA|NA OLIIENHM_03249 1440774.Y900_017415 1.9e-135 489.2 Mycobacteriaceae mce5F Bacteria 235JU@1762,2GNNJ@201174,COG1463@1,COG1463@2 NA|NA|NA Q COG1463 ABC-type transport system involved in resistance to organic solvents, periplasmic component OLIIENHM_03250 47839.CCAU010000011_gene5524 9.7e-127 460.3 Mycobacteriaceae mce5E Bacteria 234W2@1762,2H5IA@201174,COG1463@1,COG1463@2 NA|NA|NA Q COG1463 ABC-type transport system involved in resistance to organic solvents, periplasmic component OLIIENHM_03251 1440774.Y900_017425 4.4e-128 464.5 Mycobacteriaceae Bacteria 232SD@1762,2I8S5@201174,COG1463@1,COG1463@2 NA|NA|NA Q COG1463 ABC-type transport system involved in resistance to organic solvents, periplasmic component OLIIENHM_03252 1122247.C731_0899 3.5e-109 401.7 Mycobacteriaceae mce5C ko:K02067 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 233Q0@1762,2GWJT@201174,COG1463@1,COG1463@2 NA|NA|NA Q MCE family OLIIENHM_03253 246196.MSMEI_1112 1e-116 426.8 Mycobacteriaceae ko:K02067 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 234Z7@1762,2GIZQ@201174,COG1463@1,COG1463@2 NA|NA|NA Q COG1463 ABC-type transport system involved in resistance to organic solvents, periplasmic component OLIIENHM_03255 1370125.AUWT01000039_gene125 1.1e-110 406.4 Mycobacteriaceae ko:K02066 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 233WI@1762,2GJ27@201174,COG0767@1,COG0767@2 NA|NA|NA Q ABC-type transport system involved in resistance to organic solvents, permease component OLIIENHM_03256 350054.Mflv_0012 1.1e-105 389.8 Mycobacteriaceae yrbE5A ko:K02066 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 236TU@1762,2GK0A@201174,COG0767@1,COG0767@2 NA|NA|NA Q ABC-type transport system involved in resistance to organic solvents, permease component OLIIENHM_03257 1440774.Y900_011270 1.2e-93 349.7 Mycobacteriaceae Bacteria 232D8@1762,2H4MP@201174,COG1714@1,COG1714@2 NA|NA|NA S membrane protein domain OLIIENHM_03258 931627.MycrhDRAFT_0066 5e-214 750.4 Mycobacteriaceae ko:K11159 ko00000 Bacteria 232FH@1762,2GK7D@201174,COG3670@1,COG3670@2 NA|NA|NA Q dioxygenase OLIIENHM_03259 931627.MycrhDRAFT_0063 1.3e-258 898.7 Mycobacteriaceae glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 Bacteria 232GA@1762,2GM13@201174,COG0554@1,COG0554@2 NA|NA|NA F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate OLIIENHM_03260 1440774.Y900_011330 1.5e-84 319.3 Mycobacteriaceae Bacteria 234AB@1762,2GP8R@201174,COG0500@1,COG2226@2 NA|NA|NA Q Methyltransferase OLIIENHM_03261 931627.MycrhDRAFT_0061 7.5e-256 889.4 Mycobacteriaceae ybdK_1 Bacteria 234EH@1762,2GKCT@201174,COG2170@1,COG2170@2 NA|NA|NA S glutamate--cysteine ligase OLIIENHM_03262 931627.MycrhDRAFT_0045 1.4e-89 335.9 Mycobacteriaceae Bacteria 232H6@1762,2C8AX@1,2GNWS@201174,33XMC@2 NA|NA|NA S PknH-like extracellular domain OLIIENHM_03263 1078020.KEK_08787 4.6e-57 227.3 Mycobacteriaceae ohr ko:K04063 ko00000 Bacteria 238QU@1762,2IID0@201174,COG1764@1,COG1764@2 NA|NA|NA O redox protein, regulator of disulfide bond formation OLIIENHM_03264 1440774.Y900_011400 2.6e-10 71.6 Mycobacteriaceae Bacteria 23B63@1762,2AY2R@1,2GQSE@201174,31Q4I@2 NA|NA|NA OLIIENHM_03265 1440774.Y900_011405 6.6e-31 140.6 Mycobacteriaceae Bacteria 23B89@1762,2CQ6K@1,2INNI@201174,32SKJ@2 NA|NA|NA OLIIENHM_03266 931627.MycrhDRAFT_0041 5.5e-161 573.9 Mycobacteriaceae ko:K03791 ko00000 GH19 Bacteria 233Q8@1762,2GNJB@201174,COG0739@1,COG0739@2 NA|NA|NA M Domain of unknown function (DUF4185) OLIIENHM_03267 1172186.KB911465_gene4556 2e-165 588.6 Mycobacteriaceae asd GO:0003674,GO:0003824,GO:0004073,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv3708c Bacteria 234UZ@1762,2GJJ8@201174,COG0136@1,COG0136@2 NA|NA|NA E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate OLIIENHM_03268 164757.Mjls_5257 1.1e-215 755.7 Mycobacteriaceae ask GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.3,2.7.2.4 ko:K00928,ko:K12524 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480,R01773,R01775 RC00002,RC00043,RC00087 ko00000,ko00001,ko00002,ko01000 Bacteria 23547@1762,2GN0G@201174,COG0527@1,COG0527@2 NA|NA|NA E Belongs to the aspartokinase family OLIIENHM_03269 164757.Mjls_5258 6.2e-71 273.9 Mycobacteriaceae tdsD Bacteria 238YV@1762,2IHY1@201174,COG0778@1,COG0778@2 NA|NA|NA C nitroreductase OLIIENHM_03270 47839.CCAU010000005_gene383 2.4e-22 111.7 Actinobacteria Bacteria 29TN1@1,2GZY3@201174,30EVP@2 NA|NA|NA OLIIENHM_03271 1440774.Y900_011515 0.0 1078.5 Mycobacteriaceae leuA GO:0000287,GO:0003674,GO:0003824,GO:0003852,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0019752,GO:0030145,GO:0030955,GO:0031420,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0046912,GO:0046914,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 2332S@1762,2GISX@201174,COG0119@1,COG0119@2 NA|NA|NA E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) OLIIENHM_03272 504832.OCAR_4313 8.6e-144 516.9 Bradyrhizobiaceae MA20_16590 ko:K06889,ko:K07397 ko00000 Bacteria 1N2BT@1224,2TQN7@28211,3JQSS@41294,COG1073@1,COG1073@2,COG1765@1,COG1765@2 NA|NA|NA O OsmC-like protein OLIIENHM_03273 1440774.Y900_011535 1.1e-33 149.1 Mycobacteriaceae dnaQ GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016787,GO:0016788,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0045004,GO:0045005,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0090304,GO:0090305,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 232UE@1762,2GJZ0@201174,COG0847@1,COG0847@2 NA|NA|NA L DNA polymerase III OLIIENHM_03274 1440774.Y900_001825 2.1e-59 235.3 Mycobacteriaceae Bacteria 233E0@1762,2I2N6@201174,COG0494@1,COG0494@2 NA|NA|NA L pfam nudix OLIIENHM_03275 1122247.C731_2003 6.9e-60 236.9 Mycobacteriaceae Bacteria 233E0@1762,2I2N6@201174,COG0494@1,COG0494@2 NA|NA|NA L pfam nudix OLIIENHM_03276 1440774.Y900_001830 2.2e-175 621.7 Mycobacteriaceae pimA GO:0000026,GO:0000030,GO:0000287,GO:0003674,GO:0003824,GO:0004376,GO:0004377,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006644,GO:0006650,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0043167,GO:0043169,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046486,GO:0046488,GO:0046872,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.4.1.345 ko:K08256 R11702 ko00000,ko01000,ko01003 GT4 Bacteria 235A2@1762,2GKQ8@201174,COG0438@1,COG0438@2 NA|NA|NA M GDP-mannose-dependent alpha-(1-2)-phosphatidylinositol mannosyltransferase OLIIENHM_03277 1341646.CBMO010000081_gene264 2e-134 485.3 Mycobacteriaceae htrB GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.3.1.241,2.3.1.265 ko:K02517,ko:K22311 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 Bacteria 2332N@1762,2GM7B@201174,COG1560@1,COG1560@2 NA|NA|NA M Acyltransferase OLIIENHM_03278 1440774.Y900_001840 1.9e-89 335.5 Mycobacteriaceae pgsA1 GO:0003674,GO:0003824,GO:0003881,GO:0003882,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.7.8.11,2.7.8.5 ko:K00995,ko:K00999 ko00562,ko00564,ko01100,ko04070,map00562,map00564,map01100,map04070 R01801,R01802 RC00002,RC00017,RC00078,RC02795 ko00000,ko00001,ko01000 Bacteria 233MP@1762,2GYKW@201174,COG0558@1,COG0558@2 NA|NA|NA I Belongs to the CDP-alcohol phosphatidyltransferase class-I family OLIIENHM_03279 1299327.I546_2760 2.1e-75 288.5 Mycobacteriaceae hit GO:0003674,GO:0003824,GO:0003877,GO:0004551,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008796,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009987,GO:0015959,GO:0015961,GO:0015965,GO:0015967,GO:0016020,GO:0016462,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0070566,GO:0071704,GO:0071944,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 2.7.7.53 ko:K19710 ko00230,map00230 R00126,R01618 RC00002,RC02753,RC02795 ko00000,ko00001,ko01000 Bacteria 232XN@1762,2GJT5@201174,COG0537@1,COG0537@2 NA|NA|NA FG COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases OLIIENHM_03280 164757.Mjls_2281 0.0 1210.7 Mycobacteriaceae thrS GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 234M6@1762,2GKTC@201174,COG0441@1,COG0441@2 NA|NA|NA J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) OLIIENHM_03281 931627.MycrhDRAFT_4707 2.1e-38 164.9 Mycobacteriaceae Bacteria 23A1T@1762,2E4Q9@1,2II59@201174,32ZIV@2 NA|NA|NA S Putative transmembrane protein (PGPGW) OLIIENHM_03283 1440774.Y900_009595 1.1e-121 443.0 Mycobacteriaceae pabC 2.6.1.42,4.1.3.38 ko:K00826,ko:K02619 ko00270,ko00280,ko00290,ko00770,ko00790,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map00790,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R05553,R10991 RC00006,RC00036,RC01843,RC02148 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 2354U@1762,2GN5Z@201174,COG0115@1,COG0115@2 NA|NA|NA EH Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase OLIIENHM_03284 931627.MycrhDRAFT_0369 2.5e-14 84.7 Mycobacteriaceae Bacteria 23B6E@1762,2B1C8@1,2GSXU@201174,31TST@2 NA|NA|NA OLIIENHM_03285 931627.MycrhDRAFT_0370 5.3e-105 387.1 Mycobacteriaceae GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 232AY@1762,2GKGF@201174,COG4044@1,COG4044@2 NA|NA|NA S May play a role in the intracellular transport of hydrophobic ligands OLIIENHM_03286 1440774.Y900_009570 1.1e-36 159.1 Mycobacteriaceae sseC GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 Bacteria 239W3@1762,2E36U@1,2IM2G@201174,32Y6I@2 NA|NA|NA S Protein of unknown function (DUF1416) OLIIENHM_03287 1440774.Y900_009560 6.7e-52 210.3 Mycobacteriaceae Bacteria 239AT@1762,2AN8T@1,2IHRU@201174,31D6V@2 NA|NA|NA S Domain of unknown function (DUF4395) OLIIENHM_03288 1440774.Y900_009555 5e-48 197.2 Mycobacteriaceae thiX 1.8.1.8 ko:K02199,ko:K03671,ko:K03672 ko04621,ko05418,map04621,map05418 ko00000,ko00001,ko01000,ko03110 Bacteria 239K2@1762,2IKMI@201174,COG0526@1,COG0526@2 NA|NA|NA CO Thioredoxin OLIIENHM_03289 1440774.Y900_009550 2e-101 375.6 Mycobacteriaceae Bacteria 232XP@1762,2DR5D@1,2H3Y4@201174,33A8R@2 NA|NA|NA S Protein of unknown function (DUF2993) OLIIENHM_03290 1440774.Y900_009540 3.3e-114 417.9 Mycobacteriaceae Bacteria 233GE@1762,2GJGU@201174,COG0745@1,COG0745@2 NA|NA|NA KT transcriptional OLIIENHM_03291 1440774.Y900_009535 5.6e-97 360.9 Mycobacteriaceae mshD GO:0000302,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006950,GO:0006979,GO:0008080,GO:0008150,GO:0008152,GO:0009058,GO:0009268,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0010125,GO:0010126,GO:0010447,GO:0016137,GO:0016138,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0033554,GO:0034599,GO:0034614,GO:0035447,GO:0035690,GO:0040007,GO:0042221,GO:0042493,GO:0042542,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044249,GO:0044272,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051186,GO:0051188,GO:0051704,GO:0051716,GO:0070301,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071468,GO:0071704,GO:0097237,GO:0104004,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659,GO:1901700,GO:1901701 2.3.1.189,2.7.4.1 ko:K00937,ko:K15520 ko00190,ko03018,map00190,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 234VV@1762,2GM35@201174,COG0454@1,COG0456@2 NA|NA|NA K Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol OLIIENHM_03292 931627.MycrhDRAFT_0378 5.2e-148 530.8 Mycobacteriaceae pstS GO:0002682,GO:0002683,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009607,GO:0009987,GO:0009991,GO:0015698,GO:0016020,GO:0016036,GO:0030312,GO:0031347,GO:0031348,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0035821,GO:0040007,GO:0042594,GO:0043207,GO:0044003,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044413,GO:0044414,GO:0044419,GO:0044464,GO:0045088,GO:0045824,GO:0048519,GO:0048583,GO:0048585,GO:0050776,GO:0050777,GO:0050789,GO:0050896,GO:0051179,GO:0051234,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051817,GO:0051832,GO:0051833,GO:0052031,GO:0052037,GO:0052167,GO:0052170,GO:0052173,GO:0052200,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0065007,GO:0071496,GO:0071944,GO:0075136,GO:0080134 ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 ko00000,ko00001,ko00002,ko02000 3.A.1.7 Bacteria 233MY@1762,2GJXD@201174,COG0226@1,COG0226@2 NA|NA|NA P Part of the ABC transporter complex PstSACB involved in phosphate import OLIIENHM_03293 931627.MycrhDRAFT_0379 9.3e-146 523.1 Mycobacteriaceae pstC GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0009314,GO:0009628,GO:0010921,GO:0015698,GO:0016020,GO:0016021,GO:0019220,GO:0019222,GO:0031224,GO:0031226,GO:0031323,GO:0034220,GO:0035303,GO:0035435,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0051704,GO:0055085,GO:0065007,GO:0065009,GO:0071944,GO:0098656,GO:0098660,GO:0098661 ko:K02037,ko:K02038 ko02010,map02010 M00222 ko00000,ko00001,ko00002,ko02000 3.A.1.7 iAF987.Gmet_2702,ic_1306.c4652 Bacteria 233NA@1762,2GJDA@201174,COG0573@1,COG0573@2 NA|NA|NA P probably responsible for the translocation of the substrate across the membrane OLIIENHM_03294 931627.MycrhDRAFT_0380 2.1e-139 501.9 Mycobacteriaceae pstA GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0010921,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0019220,GO:0019222,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0031323,GO:0033554,GO:0034220,GO:0035303,GO:0035435,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0051704,GO:0051716,GO:0055085,GO:0065007,GO:0065009,GO:0071944,GO:0098656,GO:0098660,GO:0098661 ko:K02037,ko:K02038 ko02010,map02010 M00222 ko00000,ko00001,ko00002,ko02000 3.A.1.7 iJN746.PP_2658,iPC815.YPO4115,iYL1228.KPN_04131,iZ_1308.Z5217 Bacteria 233S3@1762,2I2F2@201174,COG0581@1,COG0581@2 NA|NA|NA P Phosphate transport system permease OLIIENHM_03295 931627.MycrhDRAFT_0381 7.6e-119 433.3 Mycobacteriaceae pstB 3.6.3.27 ko:K02036 ko02010,map02010 M00222 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 Bacteria 236W9@1762,2GJQ3@201174,COG1117@1,COG1117@2 NA|NA|NA P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system OLIIENHM_03297 557599.MKAN_05120 5e-70 270.8 Mycobacteriaceae Bacteria 233G3@1762,2I6WX@201174,COG3324@1,COG3324@2 NA|NA|NA E translation initiation factor activity OLIIENHM_03298 1440774.Y900_013065 8e-60 236.5 Mycobacteriaceae pdxH ko:K07005 ko00000 Bacteria 23DFY@1762,2H4HR@201174,COG3467@1,COG3467@2 NA|NA|NA S Pyridoxamine 5'-phosphate oxidase OLIIENHM_03299 285535.JOEY01000016_gene3640 1.2e-187 663.3 Actinobacteria manP GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563 2.7.1.191,2.7.1.202 ko:K02768,ko:K02769,ko:K02770,ko:K02793,ko:K02794,ko:K02795,ko:K02806 ko00051,ko00520,ko01100,ko01120,ko02060,map00051,map00520,map01100,map01120,map02060 M00273,M00276 R02630,R03232 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1,4.A.6.1 iSB619.SA_RS13955 Bacteria 2GJU4@201174,COG1299@1,COG1299@2,COG1445@1,COG1445@2,COG1762@1,COG1762@2 NA|NA|NA GT Phosphotransferase System OLIIENHM_03300 1343740.M271_17765 7.3e-73 280.4 Actinobacteria Bacteria 2HR6Z@201174,COG0778@1,COG0778@2 NA|NA|NA C Nitroreductase OLIIENHM_03301 931627.MycrhDRAFT_2230 5.6e-122 443.7 Mycobacteriaceae Bacteria 23654@1762,2IC0U@201174,COG1073@1,COG1073@2 NA|NA|NA S Alpha/beta hydrolase family OLIIENHM_03302 1386089.N865_04535 3e-193 681.4 Intrasporangiaceae 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 2GJSH@201174,4FFWW@85021,COG0001@1,COG0001@2 NA|NA|NA H Aminotransferase class-III OLIIENHM_03303 931627.MycrhDRAFT_3649 1.8e-165 589.0 Mycobacteriaceae ko:K11069 ko02010,map02010 M00299 ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 Bacteria 234YK@1762,2IBEC@201174,COG0687@1,COG0687@2 NA|NA|NA E Bacterial extracellular solute-binding protein OLIIENHM_03304 931627.MycrhDRAFT_1891 3e-213 748.0 Mycobacteriaceae ko:K08677 ko00000,ko01002 Bacteria 236PY@1762,2GMZ8@201174,COG4934@1,COG4934@2 NA|NA|NA O Peptidase S53 OLIIENHM_03305 1380386.JIAW01000022_gene2209 7.7e-133 481.1 Mycobacteriaceae Bacteria 232GB@1762,2GMIX@201174,COG2339@1,COG2339@2 NA|NA|NA S peptidase activity OLIIENHM_03306 557599.MKAN_15210 7.1e-30 137.9 Mycobacteriaceae Bacteria 237C0@1762,2AG2I@1,2IAKN@201174,3166W@2 NA|NA|NA OLIIENHM_03307 1437425.CSEC_0930 5.7e-46 191.8 Bacteria Bacteria COG1506@1,COG1506@2 NA|NA|NA E serine-type peptidase activity OLIIENHM_03308 1209984.BN978_02168 3.5e-113 414.5 Mycobacteriaceae 3.5.1.28 ko:K01448,ko:K17733 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko03036 Bacteria 233AT@1762,2I2P5@201174,COG5632@1,COG5632@2 NA|NA|NA M Domain of unknown function (DUF1906) OLIIENHM_03309 1341646.CBMO010000126_gene2769 5.4e-114 417.5 Mycobacteriaceae pstS ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 ko00000,ko00001,ko00002,ko02000 3.A.1.7 Bacteria 23855@1762,2GJXD@201174,COG0226@1,COG0226@2 NA|NA|NA P Part of the ABC transporter complex PstSACB involved in phosphate import OLIIENHM_03310 1341646.CBMO010000153_gene6421 7.7e-07 60.1 Mycobacteriaceae Bacteria 23EIS@1762,2BSSZ@1,2HDGB@201174,32MWC@2 NA|NA|NA OLIIENHM_03311 710421.Mycch_5260 2.1e-199 701.8 Mycobacteriaceae Bacteria 235KS@1762,2GMHU@201174,COG1020@1,COG1020@2 NA|NA|NA I Belongs to the long-chain O-acyltransferase family OLIIENHM_03312 1278078.G419_06332 7.3e-59 233.8 Nocardiaceae Bacteria 2HISP@201174,4G4PN@85025,COG0471@1,COG0471@2 NA|NA|NA P Sodium:sulfate symporter transmembrane region OLIIENHM_03314 469383.Cwoe_1001 7.8e-88 330.5 Rubrobacteria vdlC Bacteria 2IIVW@201174,4CT0F@84995,COG0300@1,COG0300@2 NA|NA|NA S Fungal family of unknown function (DUF1776) OLIIENHM_03315 931627.MycrhDRAFT_2232 7.5e-121 440.3 Mycobacteriaceae Bacteria 23EVG@1762,2ICAT@201174,COG0589@1,COG0589@2 NA|NA|NA T Belongs to the universal stress protein A family OLIIENHM_03316 1535287.JP74_09865 1.1e-50 206.8 Alphaproteobacteria Bacteria 1RF4B@1224,2U4TM@28211,COG4821@1,COG4821@2 NA|NA|NA S protein containing SIS (Sugar ISomerase) phosphosugar binding domain OLIIENHM_03317 1172186.KB911463_gene3648 9.2e-82 310.5 Mycobacteriaceae rho 3.1.26.12 ko:K03110,ko:K03628,ko:K03642,ko:K03646,ko:K07184,ko:K08300 ko02024,ko03018,ko03060,ko03070,map02024,map03018,map03060,map03070 M00335,M00394 ko00000,ko00001,ko00002,ko01000,ko02000,ko02044,ko03009,ko03019,ko03021 2.C.1.2,3.A.5.1,3.A.5.2,3.A.5.7 Bacteria 23FBN@1762,2I5M1@201174,COG3064@1,COG3064@2,COG3103@1,COG3103@2 NA|NA|NA MT Membrane OLIIENHM_03318 710687.KI912270_gene5487 3.5e-241 841.3 Mycobacteriaceae 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 GH3 Bacteria 2356S@1762,2GJ5H@201174,COG1472@1,COG1472@2 NA|NA|NA G Fibronectin type III-like domain OLIIENHM_03320 313612.L8106_03689 1.6e-38 166.4 Oscillatoriales cah 4.2.1.1 ko:K01673 ko00910,map00910 R00132,R10092 RC02807 ko00000,ko00001,ko01000 Bacteria 1G3RZ@1117,1H9V9@1150,COG0288@1,COG0288@2 NA|NA|NA P Reversible hydration of carbon dioxide OLIIENHM_03321 925409.KI911562_gene2426 2.2e-62 245.7 Sphingobacteriia cutC GO:0006873,GO:0006875,GO:0006878,GO:0008150,GO:0009987,GO:0010035,GO:0010038,GO:0019725,GO:0030003,GO:0042221,GO:0042592,GO:0046688,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0055065,GO:0055070,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0098771 ko:K06201 ko00000 Bacteria 1IRTX@117747,4NINY@976,COG3142@1,COG3142@2 NA|NA|NA P Participates in the control of copper homeostasis OLIIENHM_03322 196490.AUEZ01000026_gene1827 2.9e-39 168.7 Bradyrhizobiaceae MA20_43880 Bacteria 1MV5R@1224,2BNSJ@1,2U1AN@28211,32HG4@2,3JTG0@41294 NA|NA|NA S Domain of unknown function (DUF4337) OLIIENHM_03324 1341646.CBMO010000025_gene5409 3.5e-200 704.5 Mycobacteriaceae Bacteria 233CK@1762,2GJQG@201174,COG1680@1,COG1680@2,COG3876@1,COG3876@2 NA|NA|NA V beta-lactamase OLIIENHM_03325 1121346.KB899809_gene3711 1.3e-120 439.5 Paenibacillaceae ppaC GO:0003674,GO:0003824,GO:0004427,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006793,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0044237,GO:0044424,GO:0044464 3.6.1.1 ko:K15986 ko00190,map00190 ko00000,ko00001,ko01000 Bacteria 1TPH6@1239,26SZX@186822,4H9T8@91061,COG1227@1,COG1227@2 NA|NA|NA C Catalyzes the hydrolysis of pyrophosphate to phosphate OLIIENHM_03326 338969.Rfer_3247 6.4e-19 100.9 Betaproteobacteria Bacteria 1RI98@1224,2VSFE@28216,COG3172@1,COG3172@2 NA|NA|NA H AAA domain OLIIENHM_03327 1504319.GM45_0910 1.3e-49 203.0 Bacteria pnuC ko:K03811 ko00000,ko02000 4.B.1.1 Bacteria COG3201@1,COG3201@2 NA|NA|NA H nicotinamide mononucleotide transporter OLIIENHM_03328 350058.Mvan_5823 1.6e-83 315.8 Mycobacteriaceae cbiM ko:K02007 ko02010,map02010 M00245,M00246 ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 Bacteria 2333S@1762,2IEFC@201174,COG0310@1,COG0310@2 NA|NA|NA P Cobalt uptake substrate-specific transmembrane region OLIIENHM_03329 1440774.Y900_014375 1.8e-80 305.8 Mycobacteriaceae yoaK Bacteria 233FY@1762,2GKDV@201174,COG3619@1,COG3619@2 NA|NA|NA S Protein of unknown function (DUF1275) OLIIENHM_03330 1129374.AJE_09484 4e-48 197.6 Alteromonadaceae yaeR ko:K08234 ko00000 Bacteria 1RGZ8@1224,1S66M@1236,467D1@72275,COG0346@1,COG0346@2 NA|NA|NA E COG0346 Lactoylglutathione lyase and related lyases OLIIENHM_03331 1370121.AUWS01000071_gene102 2.9e-13 82.4 Mycobacteriaceae Bacteria 2381K@1762,2A2T9@1,2IDE3@201174,30R6S@2 NA|NA|NA OLIIENHM_03332 1341646.CBMO010000011_gene944 2e-170 605.1 Mycobacteriaceae Bacteria 2363C@1762,2IFCJ@201174,COG2030@1,COG2030@2 NA|NA|NA I dehydratase OLIIENHM_03333 164757.Mjls_5678 6.2e-267 926.4 Mycobacteriaceae yjjK ko:K06158 ko00000,ko03012 Bacteria 234X6@1762,2GK9S@201174,COG0488@1,COG0488@2 NA|NA|NA S ABC transporter OLIIENHM_03334 365528.KB891241_gene6323 1e-73 283.5 Frankiales hydD 3.1.1.24 ko:K01055 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00568 R02991 RC00825 ko00000,ko00001,ko00002,ko01000 Bacteria 2I0NW@201174,4EX2Y@85013,COG2267@1,COG2267@2 NA|NA|NA I Alpha/beta hydrolase family OLIIENHM_03335 931627.MycrhDRAFT_2212 2.7e-278 964.1 Mycobacteriaceae prfC GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016150,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02837,ko:K07133 ko00000,ko03012 Bacteria 232SV@1762,2GKQA@201174,COG4108@1,COG4108@2 NA|NA|NA J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP OLIIENHM_03336 931627.MycrhDRAFT_4210 3.5e-94 351.3 Mycobacteriaceae Bacteria 2333K@1762,2HPG9@201174,COG0398@1,COG0398@2 NA|NA|NA S Pfam SNARE associated Golgi protein OLIIENHM_03337 216594.MMAR_4089 2e-241 841.6 Mycobacteriaceae atpA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 iIT341.HP1134,iSB619.SA_RS10975,iSbBS512_1146.SbBS512_E4187 Bacteria 234FD@1762,2GJRJ@201174,COG0056@1,COG0056@2 NA|NA|NA F Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit OLIIENHM_03338 931627.MycrhDRAFT_6019 1.4e-136 493.0 Mycobacteriaceae atpH GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 ko:K02109,ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 Bacteria 232X8@1762,2GMJ5@201174,COG0711@1,COG0711@2,COG0712@1,COG0712@2 NA|NA|NA C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation OLIIENHM_03339 931627.MycrhDRAFT_6018 1.3e-42 179.5 Mycobacteriaceae atpF GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 iNJ661.Rv1306 Bacteria 238GJ@1762,2GJS4@201174,COG0711@1,COG0711@2 NA|NA|NA C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) OLIIENHM_03340 1440774.Y900_020175 4.4e-31 140.2 Mycobacteriaceae atpE GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0015988,GO:0015991,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 iNJ661.Rv1305 Bacteria 23AQH@1762,2IQZQ@201174,COG0636@1,COG0636@2 NA|NA|NA C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation OLIIENHM_03341 1440774.Y900_020170 9.5e-122 443.0 Mycobacteriaceae atpB GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 iAPECO1_1312.APECO1_2725,iE2348C_1286.E2348C_4048,iEC042_1314.EC042_4125,iECABU_c1320.ECABU_c42230,iECED1_1282.ECED1_4428,iECIAI39_1322.ECIAI39_4342,iECNA114_1301.ECNA114_3887,iECOK1_1307.ECOK1_4187,iECP_1309.ECP_3937,iECS88_1305.ECS88_4160,iECSF_1327.ECSF_3586,iECUMN_1333.ECUMN_4268,iEcSMS35_1347.EcSMS35_4106,iLF82_1304.LF82_0192,iNRG857_1313.NRG857_18615,iUMN146_1321.UM146_18880,iUMNK88_1353.UMNK88_4550,iUTI89_1310.UTI89_C4293,ic_1306.c4666 Bacteria 233WY@1762,2HN7M@201174,COG0356@1,COG0356@2 NA|NA|NA C it plays a direct role in the translocation of protons across the membrane OLIIENHM_03342 931627.MycrhDRAFT_6015 3.7e-50 204.5 Mycobacteriaceae GO:0008150,GO:0040007 Bacteria 239FC@1762,29217@1,2GPSM@201174,2ZPKF@2 NA|NA|NA S ATP synthase I chain OLIIENHM_03343 700508.D174_26875 1.9e-188 665.2 Mycobacteriaceae tagO GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0034645,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0045229,GO:0046872,GO:0046914,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:1901576 2.7.8.33,2.7.8.35 ko:K02851 R08856 RC00002 ko00000,ko01000,ko01003,ko01005 Bacteria 233ZR@1762,2GIT7@201174,COG0472@1,COG0472@2 NA|NA|NA M PFAM Glycosyl transferase family 4 OLIIENHM_03344 931627.MycrhDRAFT_6013 4.1e-97 360.9 Mycobacteriaceae ywlC GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 2.7.7.87 ko:K07566 R10463 RC00745 ko00000,ko01000,ko03009,ko03016 Bacteria 23383@1762,2GK2X@201174,COG0009@1,COG0009@2 NA|NA|NA J Belongs to the SUA5 family OLIIENHM_03345 1440774.Y900_020150 1.3e-101 376.3 Mycobacteriaceae prmC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0040007,GO:0044424,GO:0044444,GO:0044464 2.1.1.297,2.6.1.85 ko:K02493,ko:K13950 ko00790,map00790 R01716,R10806 RC00003,RC00010,RC01418,RC03279 ko00000,ko00001,ko01000,ko03012 Bacteria 235T2@1762,2GMH1@201174,COG2890@1,COG2890@2 NA|NA|NA J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif OLIIENHM_03346 547163.BN979_05513 2.1e-170 605.1 Mycobacteriaceae prfA GO:0008150,GO:0040007 ko:K02835 ko00000,ko03012 Bacteria 232ZR@1762,2GJWG@201174,COG0216@1,COG0216@2 NA|NA|NA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA OLIIENHM_03347 875328.JDM601_1297 3.5e-33 147.1 Mycobacteriaceae rpmE GO:0008150,GO:0040007 ko:K02909 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 23ANR@1762,2IQ4I@201174,COG0254@1,COG0254@2 NA|NA|NA J 50S ribosomal protein L31 OLIIENHM_03348 1440774.Y900_020135 4.1e-236 823.9 Mycobacteriaceae fadD1 ko:K00666 ko00000,ko01000,ko01004 Bacteria 233SH@1762,2GKZ6@201174,COG0318@1,COG0318@2 NA|NA|NA IQ Activates fatty acids by binding to coenzyme A OLIIENHM_03349 931627.MycrhDRAFT_4114 3.4e-171 608.2 Mycobacteriaceae ygiF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 3.6.1.25 ko:K18446 ko00000,ko01000 Bacteria 235BP@1762,2GJZH@201174,COG3025@1,COG3025@2,COG5607@1,COG5607@2 NA|NA|NA S CHAD OLIIENHM_03350 164757.Mjls_3343 3.6e-130 471.1 Mycobacteriaceae panB GO:0000287,GO:0003674,GO:0003824,GO:0003864,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0016742,GO:0019752,GO:0032787,GO:0034641,GO:0040007,GO:0042364,GO:0042398,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072330,GO:1901564,GO:1901566,GO:1901576 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 Bacteria 234HN@1762,2GJP6@201174,COG0413@1,COG0413@2 NA|NA|NA H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate OLIIENHM_03351 931627.MycrhDRAFT_4107 7.8e-226 789.6 Mycobacteriaceae 2.3.1.20 ko:K00635 ko00561,ko01100,map00561,map01100 M00089 R02251 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 Bacteria 23579@1762,2GKGU@201174,COG1020@1,COG1020@2 NA|NA|NA I Belongs to the long-chain O-acyltransferase family OLIIENHM_03352 931627.MycrhDRAFT_4106 1e-250 872.5 Mycobacteriaceae caeA GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009405,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0019538,GO:0036211,GO:0043170,GO:0043207,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0052689,GO:0071704,GO:0071944,GO:0075136,GO:1901564 Bacteria 234BG@1762,2GJYS@201174,COG0596@1,COG0596@2 NA|NA|NA S Alpha beta hydrolase OLIIENHM_03353 931627.MycrhDRAFT_4105 3e-212 744.6 Mycobacteriaceae caeA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0016787,GO:0030312,GO:0044464,GO:0071944 Bacteria 232W3@1762,2GJYS@201174,COG0596@1,COG0596@2 NA|NA|NA S Alpha beta hydrolase OLIIENHM_03356 1440774.Y900_023125 6.4e-254 882.9 Mycobacteriaceae glnA2 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 Bacteria 2340A@1762,2GJ2I@201174,COG0174@1,COG0174@2 NA|NA|NA E glutamine synthetase OLIIENHM_03357 931627.MycrhDRAFT_4101 0.0 1544.3 Mycobacteriaceae glnE GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0030312,GO:0031323,GO:0033238,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0060359,GO:0062012,GO:0065007,GO:0070566,GO:0071944,GO:0080090,GO:1901698 2.7.7.42,2.7.7.89 ko:K00982 ko00000,ko01000 Bacteria 233Q9@1762,2GJ91@201174,COG1391@1,COG1391@2 NA|NA|NA H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell OLIIENHM_03358 700508.D174_18125 1e-60 240.0 Mycobacteriaceae Bacteria 232FA@1762,2GN67@201174,COG2050@1,COG2050@2 NA|NA|NA Q thioesterase OLIIENHM_03359 1440774.Y900_023140 8.9e-132 476.5 Mycobacteriaceae Bacteria 232J9@1762,2GJT1@201174,COG2141@1,COG2141@2 NA|NA|NA C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases OLIIENHM_03360 1440774.Y900_023145 3.3e-38 164.5 Mycobacteriaceae Bacteria 23APA@1762,2IMGG@201174,COG1846@1,COG1846@2 NA|NA|NA K Transcriptional regulator OLIIENHM_03361 1370125.AUWT01000084_gene3655 7.7e-139 500.7 Mycobacteriaceae ndhF GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 ko:K00341,ko:K05577,ko:K09822 ko00190,ko01100,map00190,map01100 M00144,M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 237VF@1762,2IC3B@201174,COG1009@1,COG1009@2 NA|NA|NA CP Proton-conducting membrane transporter OLIIENHM_03362 1370125.AUWT01000084_gene3656 0.0 1146.7 Mycobacteriaceae ybcC ko:K09822 ko00000 Bacteria 234FN@1762,2ID5K@201174,COG3002@1,COG3002@2 NA|NA|NA S Belongs to the UPF0753 family OLIIENHM_03363 1370125.AUWT01000084_gene3657 4.2e-42 177.2 Mycobacteriaceae ko:K04752 ko00000 Bacteria 23A7T@1762,2IN02@201174,COG0347@1,COG0347@2 NA|NA|NA K nitrogen regulatory protein P-II OLIIENHM_03364 1440774.Y900_023165 9.5e-72 276.6 Mycobacteriaceae cah 4.2.1.1 ko:K01673 ko00910,map00910 R00132,R10092 RC02807 ko00000,ko00001,ko01000 Bacteria 23AB1@1762,2INQM@201174,COG0288@1,COG0288@2 NA|NA|NA P Reversible hydration of carbon dioxide OLIIENHM_03365 1157943.KB892705_gene3513 4.5e-24 118.2 Mycobacteriaceae Bacteria 23C3W@1762,2B551@1,2GZX3@201174,31XYK@2 NA|NA|NA OLIIENHM_03366 710685.MycrhN_4073 2e-55 223.8 Mycobacteriaceae 3.1.3.3 ko:K07315,ko:K20971 ko02025,map02025 ko00000,ko00001,ko01000,ko01001,ko02022,ko03021 Bacteria 23FCK@1762,2I43Y@201174,COG2208@1,COG2208@2,COG4251@1,COG4251@2 NA|NA|NA T GAF domain OLIIENHM_03367 1370121.AUWS01000076_gene588 7e-275 952.6 Mycobacteriaceae glnA GO:0001968,GO:0003674,GO:0003824,GO:0004356,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009405,GO:0009605,GO:0009607,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016020,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019222,GO:0019752,GO:0019899,GO:0020012,GO:0030162,GO:0030312,GO:0030682,GO:0031323,GO:0031325,GO:0032268,GO:0032270,GO:0035375,GO:0040007,GO:0043207,GO:0043436,GO:0044044,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046394,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0070613,GO:0071704,GO:0071944,GO:0075136,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1903317,GO:1903319 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 Bacteria 234G8@1762,2GMN1@201174,COG0174@1,COG0174@2 NA|NA|NA E glutamine synthetase OLIIENHM_03368 1440774.Y900_023180 5.7e-53 213.8 Mycobacteriaceae Bacteria 2391Y@1762,2IQMG@201174,COG1714@1,COG1714@2 NA|NA|NA S pfam rdd OLIIENHM_03369 350058.Mvan_3583 3e-107 394.8 Mycobacteriaceae GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 Bacteria 233DX@1762,2AUFS@1,2GIXC@201174,31K3Y@2 NA|NA|NA S Domain of unknown function (DUF4191) OLIIENHM_03370 931627.MycrhDRAFT_4092 1.2e-158 565.8 Mycobacteriaceae lipA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 R07767,R07768 RC01978 ko00000,ko00001,ko01000 Bacteria 236CU@1762,2GKD4@201174,COG0320@1,COG0320@2 NA|NA|NA H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives OLIIENHM_03371 931627.MycrhDRAFT_4091 1.8e-98 365.5 Mycobacteriaceae lipB GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0033819,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0071944,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.3.1.181 ko:K03801 ko00785,ko01100,map00785,map01100 R07766,R07769 RC00039,RC00992,RC02867 ko00000,ko00001,ko01000 Bacteria 232AE@1762,2GJIX@201174,COG0321@1,COG0321@2 NA|NA|NA H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate OLIIENHM_03372 1440774.Y900_023210 4.2e-132 477.6 Mycobacteriaceae GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006066,GO:0006629,GO:0006706,GO:0006707,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008395,GO:0009056,GO:0016020,GO:0016042,GO:0016125,GO:0016127,GO:0016491,GO:0016705,GO:0016709,GO:0020037,GO:0030312,GO:0031073,GO:0036199,GO:0044238,GO:0044281,GO:0044282,GO:0044464,GO:0046164,GO:0046906,GO:0048037,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1901615,GO:1901616,GO:1902652 ko:K07071 ko00000 Bacteria 232YW@1762,2GJS0@201174,COG1090@1,COG1090@2 NA|NA|NA S epimerase OLIIENHM_03373 1440774.Y900_023215 8.2e-136 490.0 Mycobacteriaceae sucB GO:0003674,GO:0003824,GO:0004148,GO:0005488,GO:0005504,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0008289,GO:0009405,GO:0009987,GO:0015036,GO:0016020,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0030312,GO:0031405,GO:0031406,GO:0032991,GO:0033293,GO:0036094,GO:0040007,GO:0042592,GO:0043167,GO:0043168,GO:0043177,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0045454,GO:0048037,GO:0050662,GO:0050789,GO:0050794,GO:0051704,GO:0055114,GO:0065007,GO:0065008,GO:0071944,GO:0097159,GO:1901363,GO:1901681,GO:1902494,GO:1990204 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 233UW@1762,2GMUV@201174,COG0508@1,COG0508@2 NA|NA|NA C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex OLIIENHM_03374 1123269.NX02_20905 6.6e-49 200.3 Sphingomonadales Bacteria 1MUU5@1224,2K18Q@204457,2TRZD@28211,COG0474@1,COG0474@2 NA|NA|NA P Cation transporter/ATPase, N-terminus OLIIENHM_03375 1451261.AS96_12120 1.5e-21 109.4 Bacteria Bacteria 2EI8G@1,33BZU@2 NA|NA|NA OLIIENHM_03376 1122603.ATVI01000012_gene1188 1e-20 107.1 Gammaproteobacteria Bacteria 1RBA6@1224,1ST5Z@1236,COG1573@1,COG1573@2 NA|NA|NA L Uracil DNA glycosylase superfamily OLIIENHM_03377 585530.HMPREF0183_0623 4.1e-189 667.2 Brevibacteriaceae ko:K07497 ko00000 Bacteria 2GJ3V@201174,4FARZ@85019,COG2801@1,COG2801@2 NA|NA|NA L Integrase core domain OLIIENHM_03378 1479623.JHEL01000015_gene744 4e-98 364.8 Microbacteriaceae Bacteria 2I8T6@201174,4FPZG@85023,COG0785@1,COG0785@2 NA|NA|NA O Cytochrome C biogenesis protein transmembrane region OLIIENHM_03379 585530.HMPREF0183_0626 1.3e-85 322.4 Brevibacteriaceae Bacteria 2IGPJ@201174,4FAYG@85019,COG0526@1,COG0526@2 NA|NA|NA CO Thioredoxin-like OLIIENHM_03380 585530.HMPREF0183_0627 6.4e-29 132.9 Brevibacteriaceae Bacteria 2C8F0@1,2HYXD@201174,31XBY@2,4FB3Z@85019 NA|NA|NA OLIIENHM_03381 1268303.RHODMAR_4924 6.9e-92 343.6 Nocardiaceae Bacteria 2CDDX@1,2HRSM@201174,30KNE@2,4G2N5@85025 NA|NA|NA E Helix-turn-helix domain of alkylmercury lyase OLIIENHM_03382 585530.HMPREF0183_0630 8e-263 912.5 Brevibacteriaceae merA 1.16.1.1 ko:K00520 ko00000,ko01000 Bacteria 2GJJK@201174,4F9AU@85019,COG1249@1,COG1249@2 NA|NA|NA C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family OLIIENHM_03383 585530.HMPREF0183_0631 1.6e-64 251.9 Brevibacteriaceae ko:K13638 ko00000,ko03000 Bacteria 2IMEG@201174,4FA4B@85019,COG0789@1,COG0789@2 NA|NA|NA K MerR, DNA binding OLIIENHM_03384 1229203.KI301992_gene2859 5.8e-09 66.2 Bacteria Bacteria COG1813@1,COG1813@2 NA|NA|NA K peptidyl-tyrosine sulfation OLIIENHM_03386 1440774.Y900_012275 4.1e-75 288.5 Mycobacteriaceae Bacteria 232GB@1762,2GMIX@201174,COG2339@1,COG2339@2 NA|NA|NA S peptidase activity OLIIENHM_03387 44454.NF84_00905 1.1e-13 82.0 Mycobacteriaceae Bacteria 23B69@1762,2CIE6@1,2GXDZ@201174,349NW@2 NA|NA|NA OLIIENHM_03388 931627.MycrhDRAFT_2085 7.1e-100 370.2 Mycobacteriaceae pgmB 5.4.2.11 ko:K01834 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 Bacteria 2347G@1762,2GP71@201174,COG0406@1,COG0406@2 NA|NA|NA G Belongs to the phosphoglycerate mutase family OLIIENHM_03389 1440774.Y900_012300 2.2e-133 481.9 Mycobacteriaceae pheA GO:0003674,GO:0003824,GO:0004664,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016597,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0019438,GO:0019752,GO:0031406,GO:0033585,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046417,GO:0046983,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 1.3.1.12,4.2.1.51,5.4.99.5 ko:K04517,ko:K04518,ko:K14170 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715,R01728 RC00125,RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 Bacteria 232MB@1762,2GJQ5@201174,COG0077@1,COG0077@2 NA|NA|NA E Prephenate dehydratase OLIIENHM_03390 931627.MycrhDRAFT_2088 1.8e-104 385.6 Mycobacteriaceae ko:K07052 ko00000 Bacteria 232IP@1762,2GK11@201174,COG1266@1,COG1266@2 NA|NA|NA S Abortive infection protein OLIIENHM_03391 931627.MycrhDRAFT_2089 3.1e-128 464.9 Mycobacteriaceae lytR2 Bacteria 233EA@1762,2GJJJ@201174,COG1316@1,COG1316@2 NA|NA|NA K transcriptional OLIIENHM_03392 350058.Mvan_5667 2.3e-137 495.0 Mycobacteriaceae glpQ 3.1.4.46 ko:K01126 ko00564,map00564 R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 Bacteria 233XF@1762,2GMMS@201174,COG0584@1,COG0584@2 NA|NA|NA C glycerophosphoryl diester phosphodiesterase OLIIENHM_03393 931627.MycrhDRAFT_2091 5.3e-66 257.7 Mycobacteriaceae bcsB ko:K08086,ko:K20541 ko00000,ko02000 4.D.3.1.6 Bacteria 233GQ@1762,2GKZS@201174,COG3170@1,COG3170@2 NA|NA|NA NU Domain of unknown function (DUF4328) OLIIENHM_03395 875328.JDM601_4158 1.1e-110 406.0 Mycobacteriaceae sodA GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0005488,GO:0005506,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009405,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0010035,GO:0016020,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0020012,GO:0030682,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0042597,GO:0043167,GO:0043169,GO:0043207,GO:0044237,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052059,GO:0052173,GO:0052200,GO:0052385,GO:0052550,GO:0052564,GO:0052567,GO:0052572,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0071944,GO:0072593,GO:0075136,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 ko00000,ko00001,ko01000 iNJ661.Rv3846 Bacteria 236KU@1762,2GJV8@201174,COG0605@1,COG0605@2 NA|NA|NA C radicals which are normally produced within the cells and which are toxic to biological systems OLIIENHM_03397 1440774.Y900_012335 1.7e-88 332.0 Mycobacteriaceae Bacteria 233TV@1762,2AXA6@1,2GNHB@201174,31P99@2 NA|NA|NA OLIIENHM_03398 931627.MycrhDRAFT_2095 2e-62 245.0 Mycobacteriaceae espR GO:0002791,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009605,GO:0009607,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0032879,GO:0032880,GO:0032991,GO:0032993,GO:0042802,GO:0043207,GO:0043565,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050708,GO:0050789,GO:0050794,GO:0050896,GO:0051046,GO:0051049,GO:0051171,GO:0051223,GO:0051252,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0070201,GO:0071944,GO:0075136,GO:0080090,GO:0090087,GO:0097159,GO:1901363,GO:1903506,GO:1903530,GO:2000112,GO:2001141 Bacteria 238K8@1762,2IFSD@201174,COG1476@1,COG1476@2 NA|NA|NA K transcriptional regulators OLIIENHM_03399 931627.MycrhDRAFT_2096 1.6e-117 429.5 Mycobacteriaceae Bacteria 2331N@1762,2BGKP@1,2GNVN@201174,32AJ5@2 NA|NA|NA OLIIENHM_03400 1440774.Y900_012355 5.5e-70 270.4 Mycobacteriaceae Bacteria 2366Z@1762,2ANU8@1,2HW06@201174,31DUM@2 NA|NA|NA OLIIENHM_03401 1440774.Y900_012360 1e-07 64.3 Mycobacteriaceae Bacteria 23AHS@1762,2B4BX@1,2IPCC@201174,31X3E@2 NA|NA|NA OLIIENHM_03402 1299327.I546_4835 1.6e-64 252.7 Mycobacteriaceae Bacteria 233WU@1762,2E45H@1,2GN4U@201174,32Z1I@2 NA|NA|NA OLIIENHM_03403 525368.HMPREF0591_2836 2.7e-48 198.4 Mycobacteriaceae copC ko:K07156 ko00000,ko02000 9.B.62.2 Bacteria 239G3@1762,2GMKG@201174,COG2372@1,COG2372@2 NA|NA|NA S resistance protein CopC OLIIENHM_03405 44454.NF84_00835 4.6e-69 267.3 Mycobacteriaceae rraA ko:K02553 ko00000,ko03019 Bacteria 238QS@1762,2IHQY@201174,COG0684@1,COG0684@2 NA|NA|NA H Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions OLIIENHM_03406 931627.MycrhDRAFT_2106 0.0 1199.9 Mycobacteriaceae ponA 2.4.1.129,3.4.16.4 ko:K05365,ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 GT51 Bacteria 233M5@1762,2GK21@201174,COG0744@1,COG0744@2 NA|NA|NA M penicillin-binding protein OLIIENHM_03407 1380386.JIAW01000023_gene6617 1e-156 559.7 Mycobacteriaceae ndh1 1.8.5.2 ko:K16937 ko00920,ko01120,map00920,map01120 R07177 ko00000,ko00001,ko01000 3.D.4.9 Bacteria 232VG@1762,2GNAT@201174,COG1252@1,COG1252@2 NA|NA|NA C Pyridine nucleotide-disulphide oxidoreductase OLIIENHM_03408 1440774.Y900_012475 1.1e-121 443.0 Mycobacteriaceae Bacteria 236Q0@1762,2GNX1@201174,COG3752@1,COG3752@2 NA|NA|NA S Protein of unknown function (DUF1295) OLIIENHM_03409 1299327.I546_3645 5e-291 1006.5 Mycobacteriaceae ctaD 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 Bacteria 233K8@1762,2GJHX@201174,COG0843@1,COG0843@2 NA|NA|NA C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B OLIIENHM_03410 1078020.KEK_03677 2.3e-202 711.4 Mycobacteriaceae Bacteria 233BX@1762,2GJDT@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_03411 931627.MycrhDRAFT_2140 3.5e-155 554.7 Mycobacteriaceae Bacteria 2362Z@1762,2GKVN@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_03412 1440053.JOEI01000035_gene6146 2.4e-27 128.6 Actinobacteria Bacteria 2IFH4@201174,COG2867@1,COG2867@2 NA|NA|NA I Cyclase dehydrase OLIIENHM_03413 931627.MycrhDRAFT_2153 0.0 1862.4 Mycobacteriaceae hrpA GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 ko:K03578 ko00000,ko01000 Bacteria 234WD@1762,2GIWX@201174,COG1643@1,COG1643@2 NA|NA|NA L ATP-dependent helicase OLIIENHM_03415 1440774.Y900_012535 4.3e-87 327.8 Mycobacteriaceae Bacteria 23CU8@1762,2B754@1,2H3NG@201174,3206M@2 NA|NA|NA OLIIENHM_03416 1440774.Y900_012540 6.6e-205 720.3 Mycobacteriaceae ko:K08677 ko00000,ko01002 Bacteria 23C7Q@1762,2GMZ8@201174,COG4934@1,COG4934@2 NA|NA|NA O Peptidase S53 OLIIENHM_03417 931627.MycrhDRAFT_2159 1.4e-66 259.6 Mycobacteriaceae Bacteria 2336X@1762,2HTH2@201174,COG2755@1,COG2755@2 NA|NA|NA E GDSL-like Lipase/Acylhydrolase family OLIIENHM_03418 1440774.Y900_012580 5.2e-247 860.1 Mycobacteriaceae nagE 2.7.1.193,2.7.1.199 ko:K02802,ko:K02803,ko:K02804,ko:K20116,ko:K20117,ko:K20118 ko00010,ko00520,ko02060,map00010,map00520,map02060 M00267,M00809 R02738,R05199 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.13,4.A.1.1.14,4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7,4.A.1.1.9 Bacteria 235ZF@1762,2GKPM@201174,COG1263@1,COG1263@2,COG1264@1,COG1264@2 NA|NA|NA G phosphotransferase system, EIIB OLIIENHM_03419 931627.MycrhDRAFT_2166 1.2e-58 232.6 Mycobacteriaceae crr 2.7.1.193,2.7.1.199 ko:K02777,ko:K02802,ko:K20116,ko:K20117,ko:K20118 ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111 M00265,M00266,M00267,M00268,M00270,M00272,M00303,M00806,M00809 R02738,R02780,R04111,R04394,R05132,R05199,R08559 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.1,4.A.1.1.13,4.A.1.1.14,4.A.1.1.2,4.A.1.1.9 Bacteria 239GY@1762,2GK6B@201174,COG2190@1,COG2190@2 NA|NA|NA G PTS glucose transporter subunit IIA OLIIENHM_03420 1341646.CBMO010000065_gene1396 6.2e-124 450.3 Mycobacteriaceae nagB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 3.1.1.31,3.5.99.6 ko:K01057,ko:K02564 ko00030,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00520,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R00765,R02035 RC00163,RC00537 ko00000,ko00001,ko00002,ko01000 Bacteria 237IY@1762,2GK7F@201174,COG0363@1,COG0363@2 NA|NA|NA G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion OLIIENHM_03421 547163.BN979_00256 1.6e-144 519.2 Mycobacteriaceae nagA 3.5.1.25 ko:K01443 ko00520,ko01130,map00520,map01130 R02059 RC00166,RC00300 ko00000,ko00001,ko01000 iNJ661.Rv3332 Bacteria 23469@1762,2GK1E@201174,COG1820@1,COG1820@2 NA|NA|NA G Belongs to the metallo-dependent hydrolases superfamily. NagA family OLIIENHM_03422 1380386.JIAW01000029_gene3704 4.6e-32 144.8 Mycobacteriaceae Bacteria 23A1S@1762,2IMKG@201174,COG0515@1,COG0515@2 NA|NA|NA KLT serine threonine protein kinase OLIIENHM_03423 931627.MycrhDRAFT_2172 5.2e-21 107.1 Mycobacteriaceae Bacteria 23DY4@1762,2B0R8@1,2H663@201174,321YY@2 NA|NA|NA OLIIENHM_03424 66377.JOBH01000006_gene235 1.2e-63 251.1 Actinobacteria Bacteria 2GRDZ@201174,COG5361@1,COG5361@2 NA|NA|NA S Protein of unknown function (DUF1254) OLIIENHM_03425 641491.DND132_0235 1.1e-47 197.2 Desulfovibrionales 1.4.1.1,4.3.1.12 ko:K01750,ko:K19244 ko00250,ko00330,ko00430,ko01100,ko01110,ko01130,ko01230,map00250,map00330,map00430,map01100,map01110,map01130,map01230 R00396,R00671 RC00008,RC00354 ko00000,ko00001,ko01000 Bacteria 1MWH6@1224,2MAJ3@213115,2WPJU@28221,42SUF@68525,COG2423@1,COG2423@2 NA|NA|NA E Ornithine cyclodeaminase/mu-crystallin family OLIIENHM_03426 247634.GPB2148_3766 1.7e-39 170.2 unclassified Gammaproteobacteria Bacteria 1JBXV@118884,1N5FS@1224,1SC45@1236,COG5361@1,COG5361@2 NA|NA|NA S Protein of unknown function (DUF1214) OLIIENHM_03428 1151122.AQYD01000005_gene3011 7.8e-98 363.2 Microbacteriaceae ctaE GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 iJN678.ctaE Bacteria 2GKK8@201174,4FKG9@85023,COG1845@1,COG1845@2 NA|NA|NA C Cytochrome c oxidase subunit III OLIIENHM_03429 1172186.KB911469_gene2396 4.1e-50 203.8 Mycobacteriaceae guaB GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006183,GO:0006195,GO:0006204,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009125,GO:0009126,GO:0009127,GO:0009128,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009154,GO:0009156,GO:0009158,GO:0009161,GO:0009163,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009169,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009261,GO:0009987,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046037,GO:0046039,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0072523,GO:0090407,GO:0097292,GO:0097293,GO:1901068,GO:1901070,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 232RN@1762,2GITZ@201174,COG0516@1,COG0516@2,COG0517@1,COG0517@2 NA|NA|NA F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth OLIIENHM_03430 318424.EU78_06365 2.6e-187 661.4 Mycobacteriaceae guaB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 234K3@1762,2GKVS@201174,COG0516@1,COG0516@2 NA|NA|NA F IMP dehydrogenase OLIIENHM_03431 1440774.Y900_007365 2.1e-278 964.5 Mycobacteriaceae choD GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009405,GO:0016491,GO:0016614,GO:0016899,GO:0016995,GO:0044419,GO:0051704,GO:0055114 1.1.3.6 ko:K03333 ko00984,ko01120,map00984,map01120 R01459 RC00146 ko00000,ko00001,ko01000 Bacteria 234AX@1762,2GJ3J@201174,COG2303@1,COG2303@2 NA|NA|NA E oxidoreductase OLIIENHM_03432 700508.D174_07540 4.2e-265 920.2 Mycobacteriaceae guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 iJN746.PP_1032,iLJ478.TM1820,iSF_1195.SF2553,iSFxv_1172.SFxv_2808,iS_1188.S2725,iYL1228.KPN_02833 Bacteria 23486@1762,2GM09@201174,COG0518@1,COG0518@2,COG0519@1,COG0519@2 NA|NA|NA F Catalyzes the synthesis of GMP from XMP OLIIENHM_03433 1440774.Y900_007330 1.6e-83 315.8 Mycobacteriaceae imuA GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360 ko:K14160 ko00000,ko03400 Bacteria 234HE@1762,2IIXE@201174,COG4544@1,COG4544@2 NA|NA|NA S Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division OLIIENHM_03434 1440774.Y900_007325 2.2e-237 828.2 Mycobacteriaceae dinB_2 ko:K14161 ko00000,ko03400 Bacteria 234TF@1762,2GMZ3@201174,COG0389@1,COG0389@2 NA|NA|NA L DNA polymerase OLIIENHM_03435 1440774.Y900_007320 2.2e-142 511.9 Mycobacteriaceae iunH 3.2.2.1 ko:K01239,ko:K01250 ko00230,ko00760,ko01100,map00230,map00760,map01100 R01245,R01273,R01677,R01770,R02143 RC00033,RC00063,RC00122,RC00318,RC00485 ko00000,ko00001,ko01000 Bacteria 2340U@1762,2GP6N@201174,COG1957@1,COG1957@2 NA|NA|NA F nucleoside hydrolase OLIIENHM_03436 931627.MycrhDRAFT_0840 6.2e-48 196.8 Actinobacteria ysmA ko:K07107 ko00000,ko01000 Bacteria 2IINH@201174,COG0824@1,COG0824@2 NA|NA|NA S PFAM thioesterase superfamily OLIIENHM_03437 1440774.Y900_007300 3e-80 305.1 Mycobacteriaceae Bacteria 237NH@1762,2GP71@201174,COG0406@1,COG0406@2 NA|NA|NA G phosphoglycerate mutase OLIIENHM_03438 1440774.Y900_007295 8.1e-133 479.9 Mycobacteriaceae Bacteria 2352W@1762,2GJJI@201174,COG2030@1,COG2030@2 NA|NA|NA I dehydratase OLIIENHM_03439 1440774.Y900_007290 1.7e-88 332.4 Mycobacteriaceae Bacteria 2366U@1762,2GIZ3@201174,COG1814@1,COG1814@2 NA|NA|NA S membrane OLIIENHM_03440 1041522.MCOL_V208465 1.4e-108 399.1 Mycobacteriaceae Bacteria 232TB@1762,2GN8A@201174,COG4312@1,COG4312@2 NA|NA|NA S Bacterial protein of unknown function (DUF899) OLIIENHM_03441 931627.MycrhDRAFT_0851 0.0 1868.2 Mycobacteriaceae dnaE2 GO:0000731,GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019985,GO:0030312,GO:0031668,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042276,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.6,2.7.7.7 ko:K00960,ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 2352I@1762,2GJ1P@201174,COG0587@1,COG0587@2 NA|NA|NA L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase OLIIENHM_03443 931627.MycrhDRAFT_0858 7.1e-102 376.7 Mycobacteriaceae Bacteria 2335S@1762,2HI8Q@201174,COG0778@1,COG0778@2 NA|NA|NA C nitroreductase OLIIENHM_03444 700508.D174_07785 4.4e-69 267.3 Mycobacteriaceae trmL GO:0001510,GO:0002128,GO:0002130,GO:0002131,GO:0002132,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.207 ko:K03216 ko00000,ko01000,ko03016 Bacteria 238KD@1762,2IHN9@201174,COG0219@1,COG0219@2 NA|NA|NA J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily OLIIENHM_03445 1100720.ALKN01000043_gene2747 2.5e-50 204.9 Comamonadaceae Bacteria 1MXEE@1224,2VKTD@28216,4ABHT@80864,COG1670@1,COG1670@2 NA|NA|NA J PFAM GCN5-related N-acetyltransferase OLIIENHM_03447 1440774.Y900_007230 1.9e-45 189.1 Mycobacteriaceae mfpA 4.6.1.1 ko:K05851 ko00230,ko02026,ko05111,map00230,map02026,map05111 R00089,R00434 RC00295 ko00000,ko00001,ko01000 Bacteria 234JS@1762,2I8N2@201174,COG1357@1,COG1357@2 NA|NA|NA S Pentapeptide repeat OLIIENHM_03448 875328.JDM601_0877 1.9e-113 416.4 Mycobacteriaceae GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 Bacteria 232ST@1762,2GP2N@201174,COG1403@1,COG1403@2 NA|NA|NA V HNH endonuclease OLIIENHM_03449 931627.MycrhDRAFT_0865 0.0 1241.1 Mycobacteriaceae GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006810,GO:0008150,GO:0015399,GO:0015405,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0030312,GO:0031224,GO:0042623,GO:0042626,GO:0043492,GO:0044424,GO:0044425,GO:0044444,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 ko:K01990,ko:K21397 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2342I@1762,2GKEU@201174,COG0842@1,COG0842@2,COG1131@1,COG1131@2,COG1716@1,COG1716@2 NA|NA|NA V ABC transporter OLIIENHM_03450 262316.MAP_3464 4.1e-183 647.5 Mycobacteriaceae namA Bacteria 232ET@1762,2GK8E@201174,COG1902@1,COG1902@2 NA|NA|NA C NADH flavin oxidoreductase OLIIENHM_03451 931627.MycrhDRAFT_0867 5.6e-142 510.4 Mycobacteriaceae folD GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0040007,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 Bacteria 23430@1762,2GJZS@201174,COG0190@1,COG0190@2 NA|NA|NA F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate OLIIENHM_03452 1209984.BN978_00660 4.2e-24 117.1 Mycobacteriaceae Bacteria 23API@1762,2DRQP@1,2GQM4@201174,33CNM@2 NA|NA|NA S Protein of unknown function (DUF3017) OLIIENHM_03453 1078020.KEK_23261 3.2e-106 391.3 Mycobacteriaceae Bacteria 232JV@1762,2HWAV@201174,COG0500@1,COG2226@2 NA|NA|NA Q Methyltransferase OLIIENHM_03454 1440774.Y900_007075 5e-172 610.5 Mycobacteriaceae metXA GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016020,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 R01776 RC00004,RC00041 ko00000,ko00001,ko01000 Bacteria 2355K@1762,2GKNJ@201174,COG2021@1,COG2021@2 NA|NA|NA E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine OLIIENHM_03455 1440774.Y900_007070 5.4e-213 746.9 Mycobacteriaceae metY 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 iNJ661.Rv3340 Bacteria 2359A@1762,2I2EB@201174,COG2873@1,COG2873@2 NA|NA|NA E O-acetylhomoserine sulfhydrylase OLIIENHM_03457 1440774.Y900_024365 5.8e-204 716.8 Mycobacteriaceae tyrS GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0030312,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 Bacteria 233TH@1762,2GJPR@201174,COG0162@1,COG0162@2 NA|NA|NA J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) OLIIENHM_03458 1211815.CBYP010000021_gene3294 1e-74 287.7 Frankiales crtD 1.3.99.26,1.3.99.27,1.3.99.28,1.3.99.29,1.3.99.31,5.4.99.9 ko:K01854,ko:K09845,ko:K10027 ko00052,ko00520,ko00906,ko01100,ko01110,map00052,map00520,map00906,map01100,map01110 R00505,R04787,R04798,R04800,R07517,R07520,R07523,R07534,R09009,R09691,R09692 RC00317,RC01214,RC02080,RC02088,RC02396,RC02605 ko00000,ko00001,ko01000 Bacteria 2GJAV@201174,4ETTQ@85013,COG1233@1,COG1233@2 NA|NA|NA Q Flavin containing amine oxidoreductase OLIIENHM_03459 1192034.CAP_5217 1.4e-28 133.7 Myxococcales 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 1R787@1224,2X4KB@28221,2YZ6U@29,439C7@68525,COG0204@1,COG0204@2 NA|NA|NA I Phosphate acyltransferases OLIIENHM_03460 290318.Cvib_0308 9.1e-53 214.5 Chlorobi ko:K14597 ko00906,map00906 R07544,R07546 RC00262 ko00000,ko00001 Bacteria 1FDR6@1090,COG1215@1,COG1215@2 NA|NA|NA M PFAM glycosyl transferase family 2 OLIIENHM_03461 290318.Cvib_1502 2.6e-22 113.2 Chlorobi 4.2.1.131 ko:K09844 ko00906,ko01100,map00906,map01100 R07516,R07519,R07522,R07528,R07532,R07536,R07539,R07543,R09790 RC00966 ko00000,ko00001,ko01000 Bacteria 1FDFA@1090,2DPWS@1,333QK@2 NA|NA|NA H PFAM hydroxyneurosporene synthase OLIIENHM_03462 487521.OCU_29170 5.8e-74 283.9 Mycobacteriaceae mpg GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.2.2.21 ko:K03652 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 233YK@1762,2GNW1@201174,COG2094@1,COG2094@2 NA|NA|NA L Belongs to the DNA glycosylase MPG family OLIIENHM_03463 1440774.Y900_024335 9.6e-21 105.5 Mycobacteriaceae ko:K09791 ko00000 Bacteria 23B8B@1762,2GQID@201174,COG2835@1,COG2835@2 NA|NA|NA S Trm112p-like protein OLIIENHM_03464 1440774.Y900_024330 7.7e-24 117.5 Mycobacteriaceae Bacteria 239Q7@1762,2ATYQ@1,2IJFR@201174,31JIB@2 NA|NA|NA OLIIENHM_03465 1440774.Y900_024325 0.0 1551.2 Mycobacteriaceae cfl 6.2.1.3 ko:K01897,ko:K03822 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 Bacteria 234N7@1762,2GP7I@201174,COG0318@1,COG0318@2,COG3243@1,COG3243@2 NA|NA|NA IQ synthetase OLIIENHM_03467 710686.Mycsm_02764 7e-53 213.4 Mycobacteriaceae Bacteria 238VI@1762,2I92G@201174,COG3945@1,COG3945@2 NA|NA|NA S deazaflavin-dependent nitroreductase family protein OLIIENHM_03468 1440774.Y900_020240 3.1e-67 261.5 Mycobacteriaceae ogt GO:0003674,GO:0003824,GO:0003908,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051409,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:1901360 2.1.1.63 ko:K00567 ko00000,ko01000,ko03400 Bacteria 238JK@1762,2IHXW@201174,COG0350@1,COG0350@2 NA|NA|NA L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated OLIIENHM_03469 875328.JDM601_0888 3.7e-136 491.1 Mycobacteriaceae Bacteria 2329U@1762,2GMBI@201174,COG3396@1,COG3396@2 NA|NA|NA P P-aminobenzoate N-oxygenase AurF OLIIENHM_03470 875328.JDM601_0887 4.1e-44 184.9 Mycobacteriaceae GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 233NP@1762,2GNP5@201174,COG2072@1,COG2072@2 NA|NA|NA P Domain of unknown function (DUF4873) OLIIENHM_03471 710687.KI912270_gene131 5.9e-172 610.5 Mycobacteriaceae glsA GO:0003674,GO:0003824,GO:0004359,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006543,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009084,GO:0009987,GO:0016053,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 3.5.1.2 ko:K01425 ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230 R00256,R01579 RC00010,RC02798 ko00000,ko00001,ko01000 Bacteria 236WJ@1762,2GKAV@201174,COG2066@1,COG2066@2 NA|NA|NA E Belongs to the glutaminase family OLIIENHM_03472 931627.MycrhDRAFT_6849 3e-213 748.0 Mycobacteriaceae GO:0003674,GO:0003824,GO:0004016,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006171,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009975,GO:0009987,GO:0016020,GO:0016829,GO:0016849,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046058,GO:0046390,GO:0046483,GO:0052652,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1319c Bacteria 232JH@1762,2GJRI@201174,COG2114@1,COG2114@2,COG3850@1,COG3850@2 NA|NA|NA T Thought to play a role in regulation of cellular metabolism by catalysing the synthesis of a second messenger, camp catalytic activity ATP 3',5'-cyclic AMP pyrophosphate OLIIENHM_03473 710686.Mycsm_04635 1.4e-108 399.1 Mycobacteriaceae nucS ko:K07503 ko00000,ko01000 Bacteria 2338U@1762,2GIYB@201174,COG1637@1,COG1637@2 NA|NA|NA L Cleaves both 3' and 5' ssDNA extremities of branched DNA structures OLIIENHM_03474 258533.BN977_01064 7.5e-30 136.0 Mycobacteriaceae Bacteria 23AST@1762,2E3EP@1,2GQST@201174,32YDP@2 NA|NA|NA S ATP- GTP-binding protein OLIIENHM_03475 1209984.BN978_04394 7.3e-72 276.6 Mycobacteriaceae mce 5.1.99.1 ko:K05606 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R02765,R09979 RC00780,RC02739 ko00000,ko00001,ko00002,ko01000 Bacteria 232HZ@1762,2IIPR@201174,COG0346@1,COG0346@2 NA|NA|NA E PFAM Glyoxalase bleomycin resistance protein dioxygenase OLIIENHM_03478 164757.Mjls_0504 7.4e-115 419.9 Mycobacteriaceae purA GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 Bacteria 232EC@1762,2GMP4@201174,COG0104@1,COG0104@2 NA|NA|NA F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP OLIIENHM_03479 710685.MycrhN_1310 1.1e-73 283.1 Mycobacteriaceae Bacteria 233QS@1762,2HHJ1@201174,COG2050@1,COG2050@2 NA|NA|NA Q thioesterase OLIIENHM_03480 931627.MycrhDRAFT_2995 1.6e-70 272.7 Mycobacteriaceae Bacteria 238K3@1762,29VND@1,2ICBQ@201174,30H5P@2 NA|NA|NA OLIIENHM_03481 318424.EU78_02660 7.5e-26 123.2 Mycobacteriaceae ko:K06994 ko00000 Bacteria 232JZ@1762,2GIRQ@201174,COG2409@1,COG2409@2 NA|NA|NA S pfam mmpl OLIIENHM_03482 1440774.Y900_014645 1.6e-148 532.3 Mycobacteriaceae Bacteria 232XD@1762,2GKFH@201174,COG2030@1,COG2030@2 NA|NA|NA I Acyl dehydratase OLIIENHM_03483 1108045.GORHZ_080_00050 1.5e-211 742.3 Gordoniaceae pnbA ko:K03929 ko00000,ko01000 CE10 Bacteria 2GJCN@201174,4GB7Y@85026,COG2272@1,COG2272@2 NA|NA|NA I Carboxylesterase family OLIIENHM_03484 710686.Mycsm_05710 7.6e-73 280.4 Mycobacteriaceae 3.1.1.74 ko:K08095 ko00000,ko01000 Bacteria 232RU@1762,2A1QU@1,2H5MK@201174,30PZC@2 NA|NA|NA M hydrolysis of cutin, a polyester that forms the structure of plant cuticle OLIIENHM_03485 1440774.Y900_014665 1.6e-192 678.7 Mycobacteriaceae Bacteria 233BX@1762,2GJDT@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_03486 1440774.Y900_014670 2e-131 475.7 Mycobacteriaceae Bacteria 2362Z@1762,2GKVN@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_03487 1440774.Y900_014675 2.2e-112 412.1 Mycobacteriaceae Bacteria 232ZQ@1762,2GJYR@201174,COG0657@1,COG0657@2 NA|NA|NA I Alpha beta hydrolase OLIIENHM_03488 931627.MycrhDRAFT_2641 7.7e-73 280.0 Mycobacteriaceae aac GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008080,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016020,GO:0016137,GO:0016139,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016999,GO:0017001,GO:0017144,GO:0030647,GO:0030649,GO:0034069,GO:0044237,GO:0044248,GO:0044464,GO:0047921,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901575,GO:1901657,GO:1901658 2.3.1.59 ko:K17840 br01600,ko00000,ko01000,ko01504 Bacteria 235DC@1762,2IAC7@201174,COG0454@1,COG0456@2 NA|NA|NA K Aminoglycoside 2'-N-acetyltransferase OLIIENHM_03489 931627.MycrhDRAFT_2642 2e-118 432.2 Mycobacteriaceae Bacteria 232JF@1762,2GITH@201174,COG1984@1,COG1984@2 NA|NA|NA E Allophanate hydrolase subunit 2 OLIIENHM_03490 164757.Mjls_0258 1.2e-69 269.6 Mycobacteriaceae kipI 6.3.4.6 ko:K01941 ko00220,ko00791,ko01100,map00220,map00791,map01100 R00774 RC00378 ko00000,ko00001,ko01000 Bacteria 233RB@1762,2I2R8@201174,COG2049@1,COG2049@2 NA|NA|NA E Allophanate hydrolase subunit 1 OLIIENHM_03491 931627.MycrhDRAFT_2644 1e-101 376.3 Mycobacteriaceae yhhQ ko:K09125 ko00000 Bacteria 234X8@1762,2IFDB@201174,COG1738@1,COG1738@2 NA|NA|NA S Involved in the import of queuosine (Q) precursors, required for Q precursor salvage OLIIENHM_03492 525368.HMPREF0591_3336 7.2e-48 197.2 Mycobacteriaceae Bacteria 239BN@1762,2IP3P@201174,COG1309@1,COG1309@2 NA|NA|NA K PFAM Bacterial regulatory proteins, tetR family OLIIENHM_03493 246196.MSMEI_0454 5.5e-72 277.3 Mycobacteriaceae lysE GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015174,GO:0015181,GO:0015318,GO:0015711,GO:0015802,GO:0015807,GO:0015809,GO:0015849,GO:0015893,GO:0016020,GO:0022857,GO:0034220,GO:0042221,GO:0042493,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902023,GO:1903825,GO:1903826,GO:1905039,GO:1990822 ko:K06895 ko00000,ko02000 2.A.75.1 Bacteria 233GK@1762,2IHQ2@201174,COG1279@1,COG1279@2 NA|NA|NA S Lysine exporter protein LysE YggA OLIIENHM_03494 931627.MycrhDRAFT_2751 6e-221 773.5 Mycobacteriaceae dtpT ko:K03305 ko00000 2.A.17 Bacteria 2344C@1762,2GKB1@201174,COG3104@1,COG3104@2 NA|NA|NA U amino acid peptide transporter OLIIENHM_03495 216594.MMAR_2845 1.4e-109 402.5 Mycobacteriaceae ahpC 1.11.1.15 ko:K03386 ko04214,map04214 ko00000,ko00001,ko01000,ko04147 Bacteria 234SP@1762,2GM74@201174,COG0450@1,COG0450@2 NA|NA|NA O Alkyl hydroperoxide reductase OLIIENHM_03496 882083.SacmaDRAFT_5156 2.5e-28 131.3 Pseudonocardiales 1.20.4.3 ko:K18917 ko00000,ko01000 Bacteria 2HNF0@201174,4E6IC@85010,COG0695@1,COG0695@2 NA|NA|NA O PFAM glutaredoxin OLIIENHM_03497 909613.UO65_0305 5.2e-13 81.3 Bacteria Bacteria 2A5G6@1,30U67@2 NA|NA|NA OLIIENHM_03498 164757.Mjls_5143 5.6e-45 186.8 Mycobacteriaceae lsr2 GO:0000302,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009405,GO:0009605,GO:0009628,GO:0009636,GO:0009889,GO:0009987,GO:0009991,GO:0010035,GO:0010038,GO:0010039,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0031668,GO:0033554,GO:0034641,GO:0040007,GO:0042221,GO:0042262,GO:0042493,GO:0042542,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051704,GO:0051716,GO:0060255,GO:0065007,GO:0070482,GO:0070887,GO:0071453,GO:0071496,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901700,GO:1903506,GO:2000112,GO:2001141 Bacteria 239D7@1762,2C4MW@1,2IQ6A@201174,32RKK@2 NA|NA|NA S pathogenesis OLIIENHM_03499 931627.MycrhDRAFT_0170 1e-255 889.0 Mycobacteriaceae lysS GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iAF1260.b4129,iECDH1ME8569_1439.ECDH1ME8569_3989,iECW_1372.ECW_m4490,iEcDH1_1363.EcDH1_3862,iJN678.lysS,iJO1366.b4129,iWFL_1372.ECW_m4490 Bacteria 233HE@1762,2GKE0@201174,COG1190@1,COG1190@2 NA|NA|NA J Belongs to the class-II aminoacyl-tRNA synthetase family OLIIENHM_03500 1440774.Y900_010695 3.1e-134 484.6 Mycobacteriaceae coaX GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1986 Bacteria 2347Y@1762,2GMRQ@201174,COG1521@1,COG1521@2 NA|NA|NA F Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis OLIIENHM_03501 1440774.Y900_010705 1.5e-132 479.2 Mycobacteriaceae panC GO:0000166,GO:0000287,GO:0001505,GO:0003674,GO:0003824,GO:0004592,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0019482,GO:0019752,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033317,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042133,GO:0042364,GO:0042398,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0065007,GO:0065008,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv3602c Bacteria 234RW@1762,2GJEQ@201174,COG0414@1,COG0414@2 NA|NA|NA H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate OLIIENHM_03502 1440774.Y900_010710 1.3e-136 492.7 Mycobacteriaceae Bacteria 2361Y@1762,2I2F6@201174,COG5495@1,COG5495@2 NA|NA|NA S Domain of unknown function (DUF2520) OLIIENHM_03503 931627.MycrhDRAFT_0164 2.7e-64 252.7 Mycobacteriaceae Bacteria 232BZ@1762,2F5G1@1,2HVSF@201174,33Y1Q@2 NA|NA|NA OLIIENHM_03504 931627.MycrhDRAFT_0163 5.3e-54 217.2 Mycobacteriaceae Bacteria 238UC@1762,2DRQG@1,2IFEG@201174,33CMQ@2 NA|NA|NA S Protein of unknown function (DUF3180) OLIIENHM_03505 1298864.AUEQ01000009_gene2777 6e-59 233.8 Mycobacteriaceae folK 2.7.6.3,4.1.2.25 ko:K00950,ko:K13940 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503,R03504 RC00002,RC00017,RC00721,RC00943 ko00000,ko00001,ko00002,ko01000 Bacteria 238VA@1762,2H3G6@201174,COG0801@1,COG0801@2 NA|NA|NA H 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase OLIIENHM_03506 1440774.Y900_010730 2.4e-55 221.5 Mycobacteriaceae folB GO:0008150,GO:0040007 1.13.11.81,2.7.6.3,4.1.2.25,5.1.99.8 ko:K01633,ko:K13940 ko00790,ko01100,map00790,map01100 M00126,M00840 R03503,R03504,R11037,R11073 RC00002,RC00017,RC00721,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 Bacteria 239AF@1762,2IHSW@201174,COG1539@1,COG1539@2 NA|NA|NA H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin OLIIENHM_03507 1440774.Y900_010735 2.6e-115 421.8 Mycobacteriaceae folP GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 Bacteria 233ZD@1762,2GJDQ@201174,COG0294@1,COG0294@2 NA|NA|NA H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives OLIIENHM_03508 1440774.Y900_010740 6.1e-95 353.6 Mycobacteriaceae folE GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006082,GO:0006139,GO:0006575,GO:0006725,GO:0006729,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008616,GO:0009058,GO:0009108,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0019752,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042455,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901657,GO:1901659 2.7.6.3,3.5.4.16 ko:K00950,ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R03503,R04639,R05046,R05048 RC00002,RC00017,RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 iIT341.HP0928 Bacteria 23379@1762,2GP2P@201174,COG0302@1,COG0302@2 NA|NA|NA F GTP cyclohydrolase OLIIENHM_03509 931627.MycrhDRAFT_0158 0.0 1230.3 Mycobacteriaceae ftsH GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019222,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 ko:K03798 M00742 ko00000,ko00002,ko01000,ko01002,ko03110 Bacteria 2334F@1762,2GJ4Q@201174,COG0465@1,COG0465@2 NA|NA|NA O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins OLIIENHM_03510 557599.MKAN_12455 4.6e-137 494.2 Mycobacteriaceae ephA GO:0000287,GO:0001676,GO:0002532,GO:0002538,GO:0002539,GO:0003008,GO:0003013,GO:0003674,GO:0003824,GO:0004301,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006725,GO:0006793,GO:0006796,GO:0006950,GO:0006952,GO:0006954,GO:0007600,GO:0008015,GO:0008150,GO:0008152,GO:0008217,GO:0009056,GO:0009810,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0015643,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016801,GO:0016803,GO:0018742,GO:0018904,GO:0019216,GO:0019218,GO:0019222,GO:0019233,GO:0019439,GO:0019752,GO:0030258,GO:0032501,GO:0032787,GO:0033559,GO:0042577,GO:0042578,GO:0042579,GO:0042592,GO:0042632,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043651,GO:0044237,GO:0044238,GO:0044248,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045777,GO:0046272,GO:0046483,GO:0046839,GO:0046872,GO:0046983,GO:0048518,GO:0048878,GO:0050789,GO:0050877,GO:0050896,GO:0055088,GO:0055092,GO:0060255,GO:0062012,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090181,GO:0097176,GO:1900673,GO:1901360,GO:1901361,GO:1901575 2.7.10.2,3.3.2.9 ko:K01253,ko:K08253 ko00980,ko04976,ko05204,map00980,map04976,map05204 R07013,R07014,R07027,R07071,R07072,R07082,R09410,R09417,R09443 RC01447,RC01728,RC01764,RC02528 ko00000,ko00001,ko01000,ko01002 Bacteria 232BF@1762,2I2KD@201174,COG2267@1,COG2267@2 NA|NA|NA I Alpha beta hydrolase OLIIENHM_03511 1440774.Y900_010780 1.6e-86 325.9 Mycobacteriaceae lpqG ko:K09807 ko00000 Bacteria 235EY@1762,2GM1U@201174,COG2968@1,COG2968@2 NA|NA|NA S Protein of unknown function (DUF541) OLIIENHM_03512 931627.MycrhDRAFT_0151 2.3e-88 331.6 Mycobacteriaceae hpt GO:0003674,GO:0003824,GO:0004422,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006188,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0043094,GO:0043101,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0052657,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.8,6.3.4.19 ko:K00760,ko:K04075,ko:K15780 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 R00190,R01132,R01229,R02142,R08237,R08238,R08245,R09597 RC00063,RC00122,RC02633,RC02634 ko00000,ko00001,ko01000,ko03016 Bacteria 233RV@1762,2GMDZ@201174,COG0634@1,COG0634@2 NA|NA|NA F Belongs to the purine pyrimidine phosphoribosyltransferase family OLIIENHM_03513 710421.Mycch_4728 9.6e-119 433.3 Mycobacteriaceae tilS GO:0008150,GO:0040007 2.4.2.8,6.3.4.19 ko:K04075,ko:K15780 ko00230,ko01100,ko01110,map00230,map01100,map01110 R01132,R01229,R02142,R09597 RC00063,RC00122,RC02633,RC02634 ko00000,ko00001,ko01000,ko03016 Bacteria 233ZI@1762,2GJR4@201174,COG0037@1,COG0037@2 NA|NA|NA J Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine OLIIENHM_03514 1440774.Y900_010795 3e-142 511.5 Mycobacteriaceae Bacteria 2355B@1762,2GJ8E@201174,COG5282@1,COG5282@2 NA|NA|NA S Zincin-like metallopeptidase OLIIENHM_03515 164757.Mjls_5164 5.4e-147 527.7 Mycobacteriaceae dacB 3.4.16.4 ko:K07259 ko00550,map00550 ko00000,ko00001,ko01000,ko01002,ko01011 Bacteria 236AU@1762,2GJPH@201174,COG2027@1,COG2027@2 NA|NA|NA M D-alanyl-D-alanine carboxypeptidase OLIIENHM_03516 36809.MAB_0518c 5.6e-75 287.0 Mycobacteriaceae ppa GO:0000287,GO:0003674,GO:0003824,GO:0004427,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0071944 3.6.1.1 ko:K01507 ko00190,map00190 ko00000,ko00001,ko01000 iNJ661.Rv3628 Bacteria 2355M@1762,2GM7F@201174,COG0221@1,COG0221@2 NA|NA|NA C Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions OLIIENHM_03517 931627.MycrhDRAFT_0146 6.7e-66 256.9 Mycobacteriaceae uao 4.1.1.97 ko:K16840 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R06604 RC01551 ko00000,ko00001,ko00002,ko01000 Bacteria 23F0H@1762,2IGKZ@201174,COG3195@1,COG3195@2 NA|NA|NA S OHCU decarboxylase OLIIENHM_03518 1440774.Y900_010855 3.7e-142 511.1 Mycobacteriaceae terC ko:K05794 ko00000 Bacteria 2339F@1762,2GIWU@201174,COG0861@1,COG0861@2 NA|NA|NA P membrane protein TerC OLIIENHM_03519 1440774.Y900_010860 0.0 2092.0 Mycobacteriaceae tycB Bacteria 233XI@1762,2I8TI@201174,COG0110@1,COG0110@2,COG1020@1,COG1020@2 NA|NA|NA Q non-ribosomal peptide synthetase OLIIENHM_03520 1440774.Y900_010865 2.4e-213 748.0 Mycobacteriaceae pepN_1 ko:K01269 ko00000,ko01000 Bacteria 234Q4@1762,2GJWF@201174,COG0308@1,COG0308@2 NA|NA|NA E Peptidase M1, membrane alanine aminopeptidase OLIIENHM_03521 262316.MAP_0433c 2.8e-150 538.5 Mycobacteriaceae GO:0005575,GO:0005576 ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2372Z@1762,2I8M1@201174,COG2244@1,COG2244@2 NA|NA|NA S polysaccharide biosynthetic process OLIIENHM_03522 931627.MycrhDRAFT_0132 4.7e-99 367.5 Mycobacteriaceae ko:K00786 ko00000,ko01000 Bacteria 233HS@1762,2GM44@201174,COG0463@1,COG0463@2 NA|NA|NA M glycosyl transferase OLIIENHM_03523 931627.MycrhDRAFT_0131 7.2e-45 186.4 Mycobacteriaceae ko:K09153 ko00000 Bacteria 23A7Y@1762,2GQTD@201174,COG2456@1,COG2456@2 NA|NA|NA S Uncharacterized conserved protein (DUF2304) OLIIENHM_03524 487521.OCU_04380 8.3e-123 446.8 Mycobacteriaceae galE1 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 4.2.1.46,5.1.3.2 ko:K01710,ko:K01784 ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130 M00361,M00362,M00632,M00793 R00291,R02984,R06513 RC00289,RC00402 ko00000,ko00001,ko00002,ko01000 Bacteria 23559@1762,2I2UT@201174,COG0451@1,COG0451@2 NA|NA|NA M UDP-glucose 4-epimerase OLIIENHM_03525 931627.MycrhDRAFT_0129 8.4e-249 866.3 Mycobacteriaceae ko:K03820 ko00000,ko01000 GT2 Bacteria 232SX@1762,2I2PH@201174,COG0815@1,COG0815@2 NA|NA|NA M Transfers the fatty acyl group on membrane lipoproteins OLIIENHM_03529 931627.MycrhDRAFT_0127 7e-175 620.2 Mycobacteriaceae holB GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 2344I@1762,2GJ8C@201174,COG0470@1,COG0470@2 NA|NA|NA L DNA polymerase III OLIIENHM_03530 931627.MycrhDRAFT_0126 9.8e-235 819.3 Mycobacteriaceae 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 Bacteria 2344W@1762,2GJRI@201174,COG2114@1,COG2114@2,COG3850@1,COG3850@2 NA|NA|NA T COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) OLIIENHM_03531 350058.Mvan_4628 1.8e-25 122.1 Mycobacteriaceae ko:K00389 ko00000 Bacteria 23AVT@1762,2ISPE@201174,COG2149@1,COG2149@2 NA|NA|NA S Domain of unknown function (DUF202) OLIIENHM_03532 931627.MycrhDRAFT_0125 0.0 1604.0 Mycobacteriaceae topA GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009892,GO:0010605,GO:0016020,GO:0016853,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0040007,GO:0043086,GO:0043167,GO:0043169,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060700,GO:0060701,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0140097 5.99.1.2 ko:K03168 ko00000,ko01000,ko03032,ko03400 Bacteria 232IJ@1762,2GJU7@201174,COG0550@1,COG0550@2,COG1754@1,COG1754@2 NA|NA|NA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone OLIIENHM_03533 931627.MycrhDRAFT_0124 7.9e-84 316.6 Mycobacteriaceae Bacteria 23413@1762,2EE2C@1,2GNPT@201174,337X2@2 NA|NA|NA OLIIENHM_03534 1440774.Y900_010925 5.4e-32 142.9 Mycobacteriaceae cspA_1 GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944 ko:K03704 ko00000,ko03000 Bacteria 23AQ0@1762,2GQRU@201174,COG1278@1,COG1278@2 NA|NA|NA K cold-shock protein OLIIENHM_03535 1440774.Y900_010930 0.0 1217.6 Mycobacteriaceae yprA GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 ko:K06877 ko00000 Bacteria 232TM@1762,2GJJ6@201174,COG1205@1,COG1205@2 NA|NA|NA L dead DEAH box helicase OLIIENHM_03536 1440774.Y900_010935 2.9e-121 441.8 Mycobacteriaceae Bacteria 232UB@1762,2BH0Z@1,2I8JZ@201174,32B17@2 NA|NA|NA OLIIENHM_03537 1440774.Y900_010940 1.2e-14 85.9 Mycobacteriaceae Bacteria 23BAK@1762,2DRBM@1,2GXTD@201174,33B4F@2 NA|NA|NA S TIGRFAM helicase secretion neighborhood TadE-like protein OLIIENHM_03538 710686.Mycsm_05964 1.7e-20 105.1 Mycobacteriaceae GO:0008150,GO:0010941,GO:0033668,GO:0035821,GO:0042981,GO:0043067,GO:0043069,GO:0044003,GO:0044068,GO:0044403,GO:0044419,GO:0044531,GO:0044532,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051701,GO:0051704,GO:0051817,GO:0052040,GO:0052041,GO:0052150,GO:0052248,GO:0052433,GO:0052490,GO:0060548,GO:0065007 Bacteria 23B7R@1762,2EGB2@1,2HKYZ@201174,33A2X@2 NA|NA|NA OLIIENHM_03539 83332.Rv3656c 4.1e-16 90.1 Mycobacteriaceae Bacteria 23B84@1762,2EHCF@1,2GSFV@201174,33B4A@2 NA|NA|NA S Protein of unknown function (DUF4244) OLIIENHM_03540 1440774.Y900_010970 4.2e-45 188.0 Mycobacteriaceae gspF ko:K12510,ko:K12511 ko00000,ko02044 Bacteria 2392W@1762,2IQE9@201174,COG2064@1,COG2064@2 NA|NA|NA NU type II secretion system protein OLIIENHM_03541 1440774.Y900_010975 5.5e-52 210.7 Mycobacteriaceae ko:K12510 ko00000,ko02044 Bacteria 232C1@1762,2I8NR@201174,COG4965@1,COG4965@2 NA|NA|NA U Flp pilus assembly protein TadB OLIIENHM_03542 487521.OCU_04230 5e-154 550.8 Mycobacteriaceae cpaF ko:K02283 ko00000,ko02035,ko02044 Bacteria 232G9@1762,2GKKJ@201174,COG4962@1,COG4962@2 NA|NA|NA U secretion system protein OLIIENHM_03543 1440774.Y900_011050 5.5e-99 367.9 Mycobacteriaceae cpaE GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 ko:K04562 ko00000,ko02035 Bacteria 2340I@1762,2GIVN@201174,COG0455@1,COG0455@2 NA|NA|NA D bacterial-type flagellum organization OLIIENHM_03544 931627.MycrhDRAFT_0111 1.5e-98 365.9 Mycobacteriaceae Bacteria 232QJ@1762,2GIT8@201174,COG3177@1,COG3177@2 NA|NA|NA S Filamentation induced by cAMP protein fic OLIIENHM_03545 1440774.Y900_011065 0.0 1166.0 Mycobacteriaceae acsA GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 232GK@1762,2GJCG@201174,COG0365@1,COG0365@2 NA|NA|NA I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA OLIIENHM_03546 1440774.Y900_011070 3.9e-99 367.9 Mycobacteriaceae Bacteria 23309@1762,2GJXA@201174,COG5640@1,COG5640@2 NA|NA|NA O endopeptidase activity OLIIENHM_03547 931627.MycrhDRAFT_0108 2.3e-61 241.9 Mycobacteriaceae Bacteria 233GZ@1762,2DPPE@1,2IN30@201174,332VJ@2 NA|NA|NA S Putative Actinobacterial Holin-X, holin superfamily III OLIIENHM_03548 1440774.Y900_011080 5.7e-140 503.8 Mycobacteriaceae ephE Bacteria 232I8@1762,2GJDM@201174,COG0596@1,COG0596@2 NA|NA|NA S Alpha beta hydrolase OLIIENHM_03549 547163.BN979_01681 1.1e-159 569.7 Mycobacteriaceae cvpA GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009268,GO:0009405,GO:0009628,GO:0010447,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051704,GO:0071944 Bacteria 233UH@1762,2GJ92@201174,COG0265@1,COG0265@2 NA|NA|NA O Colicin V production protein OLIIENHM_03550 1440774.Y900_011090 3.9e-107 394.4 Mycobacteriaceae nudL ko:K18568 ko00332,ko01130,map00332,map01130 R10747 RC00002 ko00000,ko00001,ko01000 Bacteria 234H3@1762,2GKG9@201174,COG0494@1,COG0494@2 NA|NA|NA L Nudix hydrolase OLIIENHM_03551 1440774.Y900_011095 5.6e-75 287.3 Mycobacteriaceae resA_1 ko:K02199 ko00000,ko03110 Bacteria 235W9@1762,2IMNX@201174,COG0526@1,COG0526@2 NA|NA|NA CO Thioredoxin-like OLIIENHM_03552 318424.EU78_24705 3.5e-115 421.0 Mycobacteriaceae nth GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0030312,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 4.2.99.18 ko:K10773 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 236ET@1762,2GJ01@201174,COG0177@1,COG0177@2 NA|NA|NA L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate OLIIENHM_03554 1209984.BN978_02799 6.3e-117 426.8 Mycobacteriaceae glxR GO:0000166,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010675,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030312,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0032993,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000874,GO:2001141 ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 ko00000,ko00001,ko03000 Bacteria 235SN@1762,2GMPN@201174,COG0664@1,COG0664@2 NA|NA|NA K COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases OLIIENHM_03555 1078020.KEK_08617 1e-110 406.4 Mycobacteriaceae MA20_07390 3.1.2.6 ko:K01069,ko:K07455 ko00620,map00620 R01736 RC00004,RC00137 ko00000,ko00001,ko01000,ko03400 Bacteria 234D9@1762,2GKP9@201174,COG0491@1,COG0491@2 NA|NA|NA S Metallo-beta-lactamase superfamily OLIIENHM_03556 931627.MycrhDRAFT_0100 3.4e-50 204.5 Mycobacteriaceae Bacteria 238P6@1762,2IHNE@201174,COG0251@1,COG0251@2 NA|NA|NA J endoribonuclease L-PSP OLIIENHM_03557 1265310.CCBD010000077_gene5449 1.8e-22 110.9 Mycobacteriaceae Bacteria 23BB2@1762,2E3JZ@1,2GQIX@201174,32YI8@2 NA|NA|NA S Domain of unknown function (DUF4177) OLIIENHM_03558 1440774.Y900_011135 1.8e-155 555.4 Mycobacteriaceae arsA GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 3.6.3.16 ko:K01551 ko00000,ko01000,ko02000 3.A.19.1,3.A.21.1,3.A.4.1 Bacteria 23492@1762,2GJ0J@201174,COG0003@1,COG0003@2 NA|NA|NA P PFAM Anion-transporting ATPase OLIIENHM_03559 931627.MycrhDRAFT_0097 5.2e-180 637.1 Mycobacteriaceae arsA 3.6.3.16 ko:K01551 ko00000,ko01000,ko02000 3.A.19.1,3.A.21.1,3.A.4.1 Bacteria 233U8@1762,2GJYN@201174,COG0003@1,COG0003@2 NA|NA|NA D anion-transporting ATPase OLIIENHM_03560 1209984.BN978_02789 9.2e-22 108.6 Mycobacteriaceae whiB4 ko:K18955 ko00000,ko03000 Bacteria 23A4E@1762,2CC1Y@1,2IQEP@201174,32TCV@2 NA|NA|NA K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA OLIIENHM_03563 998088.B565_2983 5.9e-21 105.9 Gammaproteobacteria IV02_06650 Bacteria 1N79B@1224,1SEJA@1236,2CC6G@1,32Y5Q@2 NA|NA|NA S lipoprotein OLIIENHM_03565 1370125.AUWT01000058_gene4963 1.6e-99 369.4 Mycobacteriaceae Bacteria 23F5A@1762,2I469@201174,COG0457@1,COG0457@2 NA|NA|NA S Tetratricopeptide repeat OLIIENHM_03566 931627.MycrhDRAFT_6028 7.5e-122 443.7 Mycobacteriaceae yutF GO:0000121,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009395,GO:0009987,GO:0016042,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0030145,GO:0042578,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0046434,GO:0046475,GO:0046486,GO:0046503,GO:0046872,GO:0046914,GO:0046983,GO:0050897,GO:0071704,GO:1901575 3.1.3.41 ko:K01101 ko00627,ko01120,map00627,map01120 R03024 RC00151 ko00000,ko00001,ko01000 Bacteria 233P0@1762,2GK7V@201174,COG0647@1,COG0647@2 NA|NA|NA G hydrolase OLIIENHM_03567 931627.MycrhDRAFT_6029 3.6e-12 77.0 Mycobacteriaceae Bacteria 23BA0@1762,29V0T@1,2GTMY@201174,31U8H@2 NA|NA|NA OLIIENHM_03568 164757.Mjls_2966 1.2e-117 429.5 Mycobacteriaceae tlyA GO:0000154,GO:0001510,GO:0001897,GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019835,GO:0019836,GO:0022613,GO:0031167,GO:0031640,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035821,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044003,GO:0044004,GO:0044085,GO:0044179,GO:0044237,GO:0044238,GO:0044260,GO:0044364,GO:0044403,GO:0044419,GO:0044764,GO:0046483,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.226,2.1.1.227 ko:K06442 ko00000,ko01000,ko03009 Bacteria 2347J@1762,2GJVT@201174,COG1189@1,COG1189@2 NA|NA|NA J Hemolysin TlyA OLIIENHM_03569 931627.MycrhDRAFT_6031 1.2e-129 469.5 Mycobacteriaceae nadK GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0006082,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006793,GO:0006796,GO:0006797,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 R00104 RC00002,RC00078 ko00000,ko00001,ko01000 Bacteria 233I9@1762,2GKM2@201174,COG0061@1,COG0061@2 NA|NA|NA H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP OLIIENHM_03570 258533.BN977_05140 4.2e-19 100.5 Mycobacteriaceae nuoE GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3,1.6.99.3 ko:K00334,ko:K00335,ko:K03943 ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016 M00143,M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1,3.D.1.6 Bacteria 2332U@1762,2GKG0@201174,COG1905@1,COG1905@2 NA|NA|NA C NADH dehydrogenase OLIIENHM_03571 931627.MycrhDRAFT_1352 2.5e-231 807.7 Mycobacteriaceae nuoF 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2333I@1762,2GMMC@201174,COG1894@1,COG1894@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain OLIIENHM_03572 931627.MycrhDRAFT_1351 0.0 1179.9 Mycobacteriaceae nuoG GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0048037,GO:0051536,GO:0051540,GO:0055114 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 232CD@1762,2GJGX@201174,COG1034@1,COG1034@2 NA|NA|NA C NADH-quinone oxidoreductase OLIIENHM_03573 1440774.Y900_005700 3.1e-183 647.9 Mycobacteriaceae nuoH 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 232KR@1762,2GIVY@201174,COG1005@1,COG1005@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient OLIIENHM_03574 1370125.AUWT01000008_gene214 5e-67 260.8 Mycobacteriaceae nuoI 1.6.5.3 ko:K00337,ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2347T@1762,2GJNU@201174,COG1143@1,COG1143@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient OLIIENHM_03575 1194972.MVAC_02599 1.1e-65 256.9 Mycobacteriaceae nuoJ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 233A9@1762,2GKRS@201174,COG0839@1,COG0839@2 NA|NA|NA C Belongs to the complex I subunit 6 family OLIIENHM_03576 1120936.KB907213_gene4917 2.1e-32 144.8 Streptosporangiales nuoK GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3 ko:K00340,ko:K05576 ko00190,ko01100,map00190,map01100 M00144,M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2IKV7@201174,4EJPX@85012,COG0713@1,COG0713@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient OLIIENHM_03577 247156.NFA_26570 3.1e-225 788.1 Nocardiaceae nuoL GO:0008150,GO:0009605,GO:0009607,GO:0043207,GO:0044403,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0075136 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2GIT4@201174,4FWHS@85025,COG1009@1,COG1009@2 NA|NA|NA CP NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus OLIIENHM_03581 1440774.Y900_002715 2.5e-31 141.4 Mycobacteriaceae clgR GO:0002682,GO:0002683,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006109,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009268,GO:0009408,GO:0009605,GO:0009607,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009894,GO:0009987,GO:0010447,GO:0010468,GO:0010556,GO:0010557,GO:0010565,GO:0010604,GO:0010628,GO:0010675,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0022611,GO:0030162,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031347,GO:0031348,GO:0032268,GO:0032502,GO:0033554,GO:0035821,GO:0040007,GO:0042176,GO:0043207,GO:0043565,GO:0043620,GO:0044003,GO:0044110,GO:0044111,GO:0044114,GO:0044115,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044413,GO:0044414,GO:0044419,GO:0045088,GO:0045824,GO:0045893,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048583,GO:0048585,GO:0050776,GO:0050777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051252,GO:0051254,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051817,GO:0051832,GO:0051833,GO:0052031,GO:0052037,GO:0052167,GO:0052170,GO:0052173,GO:0052200,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0060255,GO:0061136,GO:0062012,GO:0065007,GO:0075136,GO:0080090,GO:0080134,GO:0085016,GO:0090062,GO:0097159,GO:1901363,GO:1902680,GO:1902882,GO:1903050,GO:1903362,GO:1903506,GO:1903508,GO:2000112,GO:2001141 Bacteria 23A45@1762,2GR3F@201174,COG1396@1,COG1396@2 NA|NA|NA K transcriptional OLIIENHM_03582 1440774.Y900_002725 1.1e-77 296.2 Mycobacteriaceae pgsA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 Bacteria 2333C@1762,2GK5D@201174,COG0558@1,COG0558@2 NA|NA|NA I Belongs to the CDP-alcohol phosphatidyltransferase class-I family OLIIENHM_03583 931627.MycrhDRAFT_5408 6.1e-100 370.5 Mycobacteriaceae 2.1.1.334 ko:K21310 ko00920,map00920 R11546 RC02653 ko00000,ko00001,ko01000 Bacteria 2336J@1762,2GN9N@201174,COG2020@1,COG2020@2 NA|NA|NA O NnrU protein OLIIENHM_03584 931627.MycrhDRAFT_6445 3.9e-80 304.3 Mycobacteriaceae argH GO:0003674,GO:0003824,GO:0004042,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016043,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0040007,GO:0042450,GO:0042802,GO:0042803,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,4.3.2.1 ko:K00619,ko:K14681 ko00220,ko00250,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map01100,map01110,map01130,map01210,map01230 M00028,M00029,M00844 R00259,R01086 RC00004,RC00064,RC00445,RC00447 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_0946 Bacteria 233YZ@1762,2GJBT@201174,COG1246@1,COG1246@2 NA|NA|NA E N-acetylglutamate synthase OLIIENHM_03585 1440774.Y900_002740 0.0 1267.3 Mycobacteriaceae ftsK GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 ko:K03466 ko00000,ko03036 3.A.12 Bacteria 232HU@1762,2GK3T@201174,COG1674@1,COG1674@2 NA|NA|NA D FtsK SpoIIIE OLIIENHM_03586 1429046.RR21198_2154 2.3e-57 228.4 Nocardiaceae vdlD 3.1.2.20 ko:K01073 ko00000,ko01000 Bacteria 2GK6X@201174,4FZ52@85025,COG1607@1,COG1607@2 NA|NA|NA I Thioesterase superfamily OLIIENHM_03587 164757.Mjls_2107 4.2e-39 167.2 Mycobacteriaceae ycnE Bacteria 239YK@1762,2IM0B@201174,COG1359@1,COG1359@2 NA|NA|NA S Antibiotic biosynthesis monooxygenase OLIIENHM_03588 1440774.Y900_002750 8e-122 443.4 Mycobacteriaceae Bacteria 235BJ@1762,2GJ9X@201174,COG1028@1,COG1028@2 NA|NA|NA IQ reductase OLIIENHM_03589 931627.MycrhDRAFT_6438 9.7e-284 982.2 Mycobacteriaceae rnj GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004527,GO:0004532,GO:0004534,GO:0004540,GO:0005488,GO:0005515,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008409,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042802,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0090503,GO:0140098,GO:1901360 ko:K12574 ko03018,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 235AG@1762,2GIW7@201174,COG0595@1,COG0595@2 NA|NA|NA J An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay OLIIENHM_03590 710421.Mycch_2085 1.9e-137 495.4 Mycobacteriaceae dapA GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008840,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 Bacteria 232DI@1762,2GJ34@201174,COG0329@1,COG0329@2 NA|NA|NA E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) OLIIENHM_03591 931627.MycrhDRAFT_6436 5.6e-122 443.7 Mycobacteriaceae thyX GO:0000166,GO:0003674,GO:0003824,GO:0004799,GO:0005488,GO:0008150,GO:0008152,GO:0008168,GO:0016740,GO:0016741,GO:0032259,GO:0036094,GO:0040007,GO:0042083,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050797,GO:0070402,GO:0097159,GO:1901265,GO:1901363 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 R06613 RC00022,RC00332 ko00000,ko00001,ko01000 iNJ661.Rv2754c Bacteria 234FQ@1762,2HCNJ@201174,COG1351@1,COG1351@2 NA|NA|NA F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant OLIIENHM_03592 1150599.MPHLEI_08164 2.3e-170 605.1 Mycobacteriaceae ycaQ ko:K09927 ko00000 Bacteria 233HP@1762,2GJM7@201174,COG3214@1,COG3214@2 NA|NA|NA S Winged helix DNA-binding domain OLIIENHM_03593 931627.MycrhDRAFT_6434 8.9e-65 253.1 Mycobacteriaceae folA GO:0000166,GO:0003674,GO:0003824,GO:0004146,GO:0005488,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0036094,GO:0042398,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0048037,GO:0050661,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0070401,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.5.1.3 ko:K00287 ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523 M00126,M00840 R00936,R00937,R00939,R00940,R02235,R02236,R11765 RC00109,RC00110,RC00158 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv2763c Bacteria 238QZ@1762,2IM1S@201174,COG0262@1,COG0262@2 NA|NA|NA H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis OLIIENHM_03594 931627.MycrhDRAFT_6433 2.2e-63 248.1 Mycobacteriaceae thyA GO:0003674,GO:0003824,GO:0004799,GO:0006139,GO:0006220,GO:0006221,GO:0006231,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009125,GO:0009129,GO:0009130,GO:0009131,GO:0009157,GO:0009159,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009178,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0032259,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042083,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046073,GO:0046078,GO:0046079,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 Bacteria 232V5@1762,2GKY0@201174,COG0207@1,COG0207@2 NA|NA|NA F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis OLIIENHM_03600 931627.MycrhDRAFT_0398 2.4e-132 478.8 Mycobacteriaceae Bacteria 236P7@1762,2HD2H@201174,COG4974@1,COG4974@2 NA|NA|NA L Belongs to the 'phage' integrase family OLIIENHM_03601 1223544.GSI01S_33_00540 4.7e-07 61.6 Gordoniaceae Bacteria 2AQ11@1,2HIJ0@201174,31F61@2,4GF7Q@85026 NA|NA|NA OLIIENHM_03603 262316.MAP_0851 5.7e-22 110.5 Mycobacteriaceae Bacteria 23BPT@1762,2B32N@1,2GW1P@201174,31VQA@2 NA|NA|NA OLIIENHM_03604 47839.CCAU010000020_gene3549 3.1e-32 145.2 Mycobacteriaceae Bacteria 23AZP@1762,2DSAD@1,2IEP7@201174,33F8F@2 NA|NA|NA OLIIENHM_03605 680198.SCAB_53472 4.5e-28 132.1 Bacteria ko:K04775 ko00000,ko01000,ko01002 Bacteria COG3591@1,COG3591@2 NA|NA|NA E Belongs to the peptidase S1B family OLIIENHM_03606 345341.KUTG_10160 4.5e-70 271.6 Actinobacteria Bacteria 28KX4@1,2I8V3@201174,2ZAD4@2 NA|NA|NA S Protein of unknown function (Hypoth_ymh) OLIIENHM_03607 710687.KI912270_gene4919 0.0 1607.0 Actinobacteria 2.1.1.72,3.1.21.3,3.1.21.4 ko:K01153,ko:K01155,ko:K03427,ko:K09384 ko00000,ko01000,ko02048 Bacteria 2I4ZE@201174,COG4096@1,COG4096@2 NA|NA|NA L Type I site-specific restriction-modification system, R (Restriction) subunit and related OLIIENHM_03608 710687.KI912270_gene4918 7.1e-255 886.3 Actinobacteria 2.1.1.72,3.1.21.4 ko:K00571,ko:K01155,ko:K03427 ko00000,ko01000,ko02048 Bacteria 2GJKD@201174,COG0286@1,COG0286@2 NA|NA|NA L restriction endonuclease OLIIENHM_03609 710687.KI912270_gene4917 1.6e-105 389.0 Actinobacteria Bacteria 2IFNC@201174,COG1002@1,COG1002@2 NA|NA|NA V Type II restriction enzyme, methylase subunits OLIIENHM_03610 395961.Cyan7425_2608 6.4e-34 152.1 Cyanobacteria Bacteria 1GE3R@1117,2E0TW@1,32WBH@2 NA|NA|NA OLIIENHM_03612 44454.NF84_06550 3.2e-157 561.6 Mycobacteriaceae ko:K13525,ko:K13527 ko03050,ko04141,ko05134,map03050,map04141,map05134 M00342,M00400,M00403 ko00000,ko00001,ko00002,ko03019,ko03051,ko04131,ko04147 3.A.16.1 Bacteria 234EV@1762,2IA0X@201174,COG1222@1,COG1222@2 NA|NA|NA O ATPase family associated with various cellular activities (AAA) OLIIENHM_03613 216594.MMAR_4830 1.1e-100 372.9 Mycobacteriaceae Bacteria 23C38@1762,2HETJ@201174,333IC@2,arCOG08992@1 NA|NA|NA OLIIENHM_03614 216594.MMAR_4828 1.9e-119 436.4 Mycobacteriaceae Bacteria 2380S@1762,2EP1Y@1,2IC2I@201174,33GNT@2 NA|NA|NA OLIIENHM_03616 931627.MycrhDRAFT_4694 8.3e-40 170.2 Mycobacteriaceae Bacteria 239YZ@1762,2IN8Q@201174,COG1366@1,COG1366@2 NA|NA|NA T Belongs to the anti-sigma-factor antagonist family OLIIENHM_03617 1440774.Y900_001950 7.4e-32 143.7 Mycobacteriaceae Bacteria 23ASJ@1762,2IQ5E@201174,COG2172@1,COG2172@2 NA|NA|NA T Histidine kinase-like ATPase domain OLIIENHM_03620 931627.MycrhDRAFT_2418 2.1e-164 585.5 Mycobacteriaceae treS GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016310,GO:0034637,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046835,GO:0071704,GO:0071944,GO:1901576 2.4.1.18,2.7.1.175,3.2.1.1,5.4.99.16 ko:K00700,ko:K05343,ko:K16146 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01557,R02108,R02110,R02112,R09945,R11262 RC00002,RC00078,RC01816 ko00000,ko00001,ko00002,ko01000,ko04147 CBM48,GH13 Bacteria 233ET@1762,2GKAP@201174,COG3281@1,COG3281@2 NA|NA|NA G Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) OLIIENHM_03621 649831.L083_5206 0.0 1083.6 Micromonosporales treS GO:0000023,GO:0000271,GO:0003674,GO:0003824,GO:0004553,GO:0004556,GO:0005488,GO:0005509,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009311,GO:0009312,GO:0009987,GO:0015980,GO:0016020,GO:0016051,GO:0016160,GO:0016161,GO:0016787,GO:0016798,GO:0016853,GO:0016866,GO:0033692,GO:0034637,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046872,GO:0047471,GO:0055114,GO:0071704,GO:0071944,GO:1901576 3.2.1.1,5.4.99.16 ko:K05343 ko00500,ko01100,map00500,map01100 R01557,R02108,R02112,R11262 RC01816 ko00000,ko00001,ko01000 GH13 iNJ661.Rv0126 Bacteria 2GIV1@201174,4DAHA@85008,COG0366@1,COG0366@2 NA|NA|NA G Maltogenic Amylase, C-terminal domain OLIIENHM_03622 1440774.Y900_013825 4.2e-154 550.8 Mycobacteriaceae fadB4 1.6.5.5 ko:K00344 ko00000,ko01000 Bacteria 2334Q@1762,2GK7Y@201174,COG0604@1,COG0604@2 NA|NA|NA C NADPH quinone OLIIENHM_03623 1440774.Y900_013820 5.5e-59 233.8 Mycobacteriaceae ko:K03624,ko:K06140 ko00000,ko03000,ko03021 Bacteria 238Y6@1762,2IFIF@201174,COG0782@1,COG0782@2 NA|NA|NA K Transcription elongation factor, GreA/GreB, C-term OLIIENHM_03624 931627.MycrhDRAFT_2408 4.7e-106 391.0 Mycobacteriaceae MA20_19930 ko:K07226 ko00000 Bacteria 233E1@1762,2GK2B@201174,COG0748@1,COG0748@2 NA|NA|NA P pyridoxamine 5'-phosphate OLIIENHM_03625 1078020.KEK_16628 3e-109 401.7 Mycobacteriaceae ko:K06889 ko00000 Bacteria 2366C@1762,2GNB6@201174,COG1073@1,COG1073@2 NA|NA|NA S Alpha beta OLIIENHM_03626 931627.MycrhDRAFT_2404 7.6e-14 82.8 Mycobacteriaceae Bacteria 23B9M@1762,2B125@1,2GSCC@201174,31TFJ@2 NA|NA|NA OLIIENHM_03627 1440774.Y900_013770 3.1e-143 514.6 Mycobacteriaceae Bacteria 2385I@1762,2GJTP@201174,COG2141@1,COG2141@2 NA|NA|NA C Luciferase-like monooxygenase OLIIENHM_03628 931627.MycrhDRAFT_2397 2.2e-256 891.3 Mycobacteriaceae 6.2.1.42 ko:K00666,ko:K18688 ko00000,ko01000,ko01004 Bacteria 232FY@1762,2GJA2@201174,COG0318@1,COG0318@2 NA|NA|NA IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II OLIIENHM_03629 710686.Mycsm_02082 4e-28 131.7 Mycobacteriaceae cprA Bacteria 236AQ@1762,2I8MS@201174,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family OLIIENHM_03630 931627.MycrhDRAFT_2390 5.1e-56 224.2 Mycobacteriaceae yxaF GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141 ko:K16137,ko:K18939 M00715 ko00000,ko00002,ko03000 Bacteria 238YC@1762,2HR0A@201174,COG1309@1,COG1309@2 NA|NA|NA K Transcriptional regulator OLIIENHM_03631 931627.MycrhDRAFT_2389 0.0 1260.7 Mycobacteriaceae 1.17.1.9 ko:K00122 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 R00519 RC02796 ko00000,ko00001,ko01000 Bacteria 232Y5@1762,2GNYQ@201174,COG0243@1,COG0243@2 NA|NA|NA C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family OLIIENHM_03632 164757.Mjls_3960 2.9e-173 615.1 Mycobacteriaceae 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 Bacteria 234KE@1762,2GIUC@201174,COG0318@1,COG0318@2 NA|NA|NA IQ AMP-dependent synthetase OLIIENHM_03633 1078020.KEK_03807 6.8e-55 219.9 Mycobacteriaceae Bacteria 238SQ@1762,2E3FZ@1,2IGAC@201174,32YET@2 NA|NA|NA OLIIENHM_03634 1440774.Y900_013650 2e-58 231.9 Mycobacteriaceae Bacteria 232K2@1762,2GXK6@201174,COG0654@1,COG0654@2 NA|NA|NA CH COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases OLIIENHM_03636 1440774.Y900_006790 2.4e-109 401.7 Mycobacteriaceae nei GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 4.2.99.18 ko:K05522 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 232F6@1762,2GKCW@201174,COG0266@1,COG0266@2 NA|NA|NA L Belongs to the FPG family OLIIENHM_03637 1440774.Y900_006795 8e-46 190.3 Mycobacteriaceae Bacteria 23ANW@1762,2IRT4@201174,COG3119@1,COG3119@2 NA|NA|NA P arylsulfatase activity OLIIENHM_03638 1206733.BAGC01000044_gene858 1.3e-85 323.2 Nocardiaceae 3.8.1.5 ko:K01563 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 R05284,R05367,R05368,R05369,R05370,R07669,R07670 RC01317,RC01340,RC01341,RC02013 ko00000,ko00001,ko01000 Bacteria 2I2VI@201174,4G9U0@85025,COG0596@1,COG0596@2 NA|NA|NA S Alpha/beta hydrolase family OLIIENHM_03639 1440774.Y900_006800 1e-111 409.8 Mycobacteriaceae rluA 5.4.99.28,5.4.99.29 ko:K06177 ko00000,ko01000,ko03009,ko03016 Bacteria 235QY@1762,2GJ2Z@201174,COG0564@1,COG0564@2 NA|NA|NA J pseudouridine synthase OLIIENHM_03640 246196.MSMEI_4171 2.7e-53 214.5 Mycobacteriaceae erpA GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009061,GO:0009987,GO:0010467,GO:0015980,GO:0016020,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055114,GO:0071704,GO:0071840,GO:0071944,GO:1901564 ko:K13628,ko:K15724 ko00000,ko03016 Bacteria 2398Y@1762,2IHR0@201174,COG0316@1,COG0316@2 NA|NA|NA S Belongs to the HesB IscA family OLIIENHM_03641 1440774.Y900_023280 4.7e-53 214.5 Mycobacteriaceae GO:0005575,GO:0005576 Bacteria 2372P@1762,2C56Y@1,2IE9V@201174,301YK@2 NA|NA|NA OLIIENHM_03642 875328.JDM601_1700 2.4e-149 535.0 Mycobacteriaceae adoK GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004001,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005975,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019200,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032552,GO:0032553,GO:0032554,GO:0032555,GO:0032559,GO:0032560,GO:0032561,GO:0032567,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046390,GO:0046483,GO:0046835,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.15,2.7.1.20 ko:K00852,ko:K00856 ko00030,ko00230,ko01100,map00030,map00230,map01100 R00185,R01051,R02750 RC00002,RC00017 ko00000,ko00001,ko01000 iAF987.Gmet_2683 Bacteria 233MA@1762,2GKBG@201174,COG0524@1,COG0524@2 NA|NA|NA G Ribokinase OLIIENHM_03643 931627.MycrhDRAFT_4072 0.0 1112.4 Mycobacteriaceae asnB GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 R00578 RC00010 ko00000,ko00001,ko01000,ko01002 Bacteria 235BG@1762,2GJIM@201174,COG0367@1,COG0367@2 NA|NA|NA E Asparagine synthase OLIIENHM_03644 1440774.Y900_023295 2.7e-151 541.6 Mycobacteriaceae ctaC GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0040007,GO:0042773,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044238,GO:0044281,GO:0044403,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0051704,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 Bacteria 232J0@1762,2GNXA@201174,COG1622@1,COG1622@2 NA|NA|NA C cytochrome C oxidase (Subunit OLIIENHM_03645 1440774.Y900_023300 9.2e-58 229.6 Mycobacteriaceae ctaF GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 238K4@1762,2D9MJ@1,2IFFM@201174,32TTI@2 NA|NA|NA C Belongs to the cytochrome c oxidase bacterial subunit CtaF family OLIIENHM_03646 931627.MycrhDRAFT_4069 2.9e-66 258.8 Mycobacteriaceae mmpS3 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 Bacteria 23290@1762,2A3D5@1,2H50P@201174,30RVM@2 NA|NA|NA S Mycobacterium membrane protein OLIIENHM_03647 931627.MycrhDRAFT_4068 9e-44 183.7 Mycobacteriaceae Bacteria 238TD@1762,2AGKA@1,2IFKQ@201174,316TG@2 NA|NA|NA S Protein of unknown function (DUF2561) OLIIENHM_03648 1435356.Y013_20955 7.5e-87 327.0 Nocardiaceae Bacteria 2I2D4@201174,4G9DC@85025,COG3618@1,COG3618@2 NA|NA|NA S Amidohydrolase OLIIENHM_03649 557599.MKAN_02880 2.6e-273 947.6 Mycobacteriaceae petD GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009512,GO:0009579,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0040007,GO:0044424,GO:0044425,GO:0044436,GO:0044459,GO:0044464,GO:0070069,GO:0071944 ko:K00412,ko:K02635,ko:K02637,ko:K03887,ko:K03891,ko:K15879 ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152,M00162 ko00000,ko00001,ko00002,ko00194,ko03029 Bacteria 234R6@1762,2GJ1E@201174,COG1290@1,COG1290@2 NA|NA|NA C Cytochrome b OLIIENHM_03650 710421.Mycch_3198 4e-188 664.1 Mycobacteriaceae qcrA GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K03890,ko:K15878 ko00190,ko01100,map00190,map01100 M00151 ko00000,ko00001,ko00002 iAF987.Gmet_0538 Bacteria 232NB@1762,2GIX6@201174,COG0723@1,COG0723@2 NA|NA|NA C c reductase, iron-sulfur subunit OLIIENHM_03651 931627.MycrhDRAFT_4063 2e-125 455.3 Mycobacteriaceae qcrC GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K00406,ko:K03889 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00151,M00156 ko00000,ko00001,ko00002 3.D.4.3 Bacteria 232RD@1762,2GKUB@201174,COG2010@1,COG2010@2 NA|NA|NA C cytochrome C OLIIENHM_03652 1440774.Y900_023330 1.2e-89 335.9 Mycobacteriaceae ctaE GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 iJN678.ctaE Bacteria 233AV@1762,2GKK8@201174,COG1845@1,COG1845@2 NA|NA|NA C cytochrome c oxidase, subunit III OLIIENHM_03653 1440774.Y900_023335 9.3e-154 549.7 Mycobacteriaceae trpD GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 ko:K00766,ko:K13497 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R00985,R00986,R01073 RC00010,RC00440,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 Bacteria 235HB@1762,2GM4G@201174,COG0547@1,COG0547@2 NA|NA|NA F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) OLIIENHM_03654 931627.MycrhDRAFT_4060 3.3e-264 917.5 Mycobacteriaceae cho GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006289,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009380,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016787,GO:0016788,GO:0030312,GO:0031668,GO:0032991,GO:0033554,GO:0033683,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1902494,GO:1905347,GO:1905348,GO:1990391 2.7.7.7 ko:K02342,ko:K03763,ko:K05984 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 235F4@1762,2GMC0@201174,COG0322@1,COG0322@2,COG0847@1,COG0847@2 NA|NA|NA L DNA polymerase III, epsilon subunit OLIIENHM_03655 1408452.JAGZ01000001_gene3466 3.5e-27 127.1 Mycobacteriaceae Bacteria 23BB4@1762,2EGHN@1,2GSZ1@201174,33A9R@2 NA|NA|NA OLIIENHM_03656 1440774.Y900_023350 1.6e-106 392.9 Mycobacteriaceae GO:0005575,GO:0005576 ko:K21471 ko00000,ko01000,ko01002,ko01011 Bacteria 233BD@1762,2GIWB@201174,COG0791@1,COG0791@2 NA|NA|NA M NlpC/P60 family OLIIENHM_03657 1440774.Y900_023355 1.3e-88 332.8 Mycobacteriaceae Bacteria 23F9R@1762,2I2Y7@201174,COG3975@1,COG3975@2 NA|NA|NA OLIIENHM_03658 1440774.Y900_023360 3.8e-170 604.4 Mycobacteriaceae pimB GO:0000009,GO:0000030,GO:0003674,GO:0003824,GO:0004376,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0033164,GO:0040007,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.4.1.346,3.2.1.8 ko:K01181,ko:K13668 R11703,R11704 ko00000,ko01000,ko01003 GT4 Bacteria 2336Q@1762,2GM6D@201174,COG0438@1,COG0438@2 NA|NA|NA M GDP-mannose-dependent alpha-(1-6)-phosphatidylinositol monomannoside mannosyltransferase OLIIENHM_03659 1440774.Y900_023385 6.8e-55 219.9 Mycobacteriaceae ko:K05554 ko01056,ko01130,map01056,map01130 M00778 R09265 RC02546 ko00000,ko00001,ko00002,ko01000,ko01004,ko01008 Bacteria 2397H@1762,2IIBS@201174,COG2867@1,COG2867@2 NA|NA|NA I negative regulation of translational initiation OLIIENHM_03660 1440774.Y900_023390 7.8e-63 246.5 Mycobacteriaceae Bacteria 238KW@1762,2IFH4@201174,COG2867@1,COG2867@2 NA|NA|NA I cyclase dehydrase OLIIENHM_03661 1440774.Y900_023395 8.5e-171 606.7 Mycobacteriaceae arsA 3.6.3.16 ko:K01551 ko00000,ko01000,ko02000 3.A.19.1,3.A.21.1,3.A.4.1 Bacteria 2346X@1762,2GISZ@201174,COG0003@1,COG0003@2 NA|NA|NA P anion-transporting ATPase OLIIENHM_03662 1209984.BN978_05901 6.2e-35 153.7 Mycobacteriaceae Bacteria 239X6@1762,2BVNB@1,2IMWU@201174,2ZDG3@2 NA|NA|NA OLIIENHM_03663 1440774.Y900_023405 9e-117 426.4 Mycobacteriaceae 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 232ZS@1762,2GJ6V@201174,COG0204@1,COG0204@2 NA|NA|NA I Acyltransferase OLIIENHM_03664 931627.MycrhDRAFT_4046 1.8e-160 572.4 Mycobacteriaceae GO:0000026,GO:0000030,GO:0003674,GO:0003824,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0070085,GO:0071704,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509 ko:K13671 ko00000,ko01000,ko01003 GT87 Bacteria 236FB@1762,2GJBC@201174,COG5650@1,COG5650@2 NA|NA|NA S phosphatidylinositol metabolic process OLIIENHM_03665 931627.MycrhDRAFT_4045 5.9e-112 410.6 Mycobacteriaceae Bacteria 233CT@1762,2GM70@201174,COG4325@1,COG4325@2 NA|NA|NA M Membrane OLIIENHM_03666 931627.MycrhDRAFT_4044 4.1e-82 310.8 Mycobacteriaceae GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0040007,GO:0042802 Bacteria 236RU@1762,2CPKU@1,2I3ZF@201174,32SJD@2 NA|NA|NA G Exonuclease that cleaves single-stranded 3' overhangs of double-stranded RNA OLIIENHM_03668 931627.MycrhDRAFT_6700 3.1e-56 224.6 Mycobacteriaceae uspA3 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0042221,GO:0044464,GO:0046677,GO:0050896,GO:0071944 Bacteria 238NE@1762,2IMMM@201174,COG0589@1,COG0589@2 NA|NA|NA T Universal stress protein OLIIENHM_03669 931627.MycrhDRAFT_6699 3e-187 661.8 Mycobacteriaceae ko:K14340 ko00000,ko01000,ko01003 Bacteria 23626@1762,2I48D@201174,COG1807@1,COG1807@2 NA|NA|NA M Dolichyl-phosphate-mannose-protein mannosyltransferase OLIIENHM_03670 710686.Mycsm_02695 1.6e-104 386.0 Mycobacteriaceae lppS Bacteria 2343M@1762,2GMT4@201174,COG1376@1,COG1376@2 NA|NA|NA S L,D-transpeptidase catalytic domain OLIIENHM_03672 1440774.Y900_024025 1.5e-108 399.1 Mycobacteriaceae uvrB GO:0002682,GO:0002684,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006950,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044424,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136 ko:K03702,ko:K08999 ko03420,map03420 ko00000,ko00001,ko03400 Bacteria 232N1@1762,2GJ03@201174,COG0556@1,COG0556@2 NA|NA|NA L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage OLIIENHM_03673 1440774.Y900_003700 7.4e-165 587.0 Mycobacteriaceae recG GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 ko:K03655 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 233IH@1762,2GKA3@201174,COG1200@1,COG1200@2 NA|NA|NA L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) OLIIENHM_03674 1440774.Y900_003705 2.9e-184 651.7 Mycobacteriaceae dak3 2.7.1.28,2.7.1.29,4.6.1.15 ko:K00863,ko:K07030 ko00051,ko00561,ko00680,ko01100,ko01120,ko01200,ko04622,map00051,map00561,map00680,map01100,map01120,map01200,map04622 M00344 R01011,R01059 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 234X7@1762,2GKII@201174,COG1461@1,COG1461@2 NA|NA|NA S Dihydroxyacetone kinase OLIIENHM_03675 36809.MAB_3280 1.7e-30 137.9 Mycobacteriaceae rpmB GO:0003674,GO:0003735,GO:0005198 ko:K02902 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 23ARN@1762,2GQNU@201174,COG0227@1,COG0227@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL28 family OLIIENHM_03676 1440774.Y900_003715 6.8e-111 406.8 Mycobacteriaceae ung GO:0003674,GO:0003824,GO:0004844,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0097510,GO:0140097,GO:1901360 3.2.2.27 ko:K03648 ko03410,ko05340,map03410,map05340 ko00000,ko00001,ko01000,ko03400 Bacteria 234RK@1762,2GJ9Z@201174,COG0692@1,COG0692@2 NA|NA|NA L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine OLIIENHM_03677 1440774.Y900_003720 1.4e-125 456.1 Mycobacteriaceae thiL GO:0008150,GO:0040007 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv2977c,iYO844.BSU05900 Bacteria 2352F@1762,2GP6E@201174,COG0611@1,COG0611@2 NA|NA|NA H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 OLIIENHM_03678 1440774.Y900_003730 2.5e-52 211.8 Mycobacteriaceae Bacteria 239AK@1762,2ECK0@1,2IGST@201174,336I4@2 NA|NA|NA S Protein of unknown function (DUF3515) OLIIENHM_03679 1440774.Y900_003735 3.6e-148 531.2 Mycobacteriaceae ddl GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008716,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 iAF1260.b0381,iB21_1397.B21_00332,iBWG_1329.BWG_0265,iE2348C_1286.E2348C_0317,iEC042_1314.EC042_0413,iEC55989_1330.EC55989_0386,iECBD_1354.ECBD_3283,iECB_1328.ECB_00328,iECDH10B_1368.ECDH10B_0338,iECDH1ME8569_1439.ECDH1ME8569_0367,iECD_1391.ECD_00328,iECH74115_1262.ECH74115_0453,iECIAI1_1343.ECIAI1_0377,iECIAI39_1322.ECIAI39_0301,iECO103_1326.ECO103_0356,iECO111_1330.ECO111_0411,iECO26_1355.ECO26_0414,iECSE_1348.ECSE_0401,iECSP_1301.ECSP_0441,iECs_1301.ECs0431,iETEC_1333.ETEC_0434,iEcDH1_1363.EcDH1_3227,iEcE24377_1341.EcE24377A_0406,iEcHS_1320.EcHS_A0447,iEcSMS35_1347.EcSMS35_0410,iEcolC_1368.EcolC_3251,iJO1366.b0381,iJR904.b0381,iSF_1195.SF0232,iSFxv_1172.SFxv_0245,iS_1188.S0254,iUMNK88_1353.UMNK88_429,iY75_1357.Y75_RS01965,iZ_1308.Z0477 Bacteria 2334U@1762,2GITC@201174,COG1181@1,COG1181@2 NA|NA|NA F Belongs to the D-alanine--D-alanine ligase family OLIIENHM_03680 931627.MycrhDRAFT_1902 1.2e-155 556.2 Mycobacteriaceae cysA 4.4.1.1,4.4.1.8 ko:K01758,ko:K01760 ko00260,ko00270,ko00450,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map01100,map01110,map01130,map01230 M00017,M00338 R00782,R01001,R01286,R02408,R04770,R04930,R04941,R09366 RC00056,RC00069,RC00348,RC00382,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 232UA@1762,2GMD8@201174,COG0626@1,COG0626@2 NA|NA|NA E PFAM Cys Met metabolism OLIIENHM_03681 1440774.Y900_003745 3.4e-149 534.6 Mycobacteriaceae gpsA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 R00842,R00844 RC00029 ko00000,ko00001,ko01000 Bacteria 234Q1@1762,2GJSD@201174,COG0240@1,COG0240@2 NA|NA|NA I Glycerol-3-phosphate dehydrogenase OLIIENHM_03682 1122247.C731_1686 3.5e-69 268.1 Mycobacteriaceae cofC GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0043814,GO:0044237,GO:0044249,GO:0051186,GO:0051188,GO:0070568 2.7.7.68 ko:K14941 ko00680,ko01120,map00680,map01120 M00378 R09397 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 233J8@1762,2HJNU@201174,COG1920@1,COG1920@2 NA|NA|NA H Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor OLIIENHM_03684 1122175.ATXU01000022_gene1580 7.1e-124 449.9 Microbacteriaceae Bacteria 2IH5H@201174,4FSDK@85023,COG0684@1,COG0684@2 NA|NA|NA H Aldolase/RraA OLIIENHM_03685 1110697.NCAST_18_01410 1.7e-85 322.0 Nocardiaceae msrA 1.8.4.11,1.8.4.12 ko:K07304,ko:K12267 ko00000,ko01000 Bacteria 2GJ1S@201174,4FXDF@85025,COG0225@1,COG0225@2 NA|NA|NA O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine OLIIENHM_03686 262316.MAP_3555 2.1e-72 278.5 Mycobacteriaceae Bacteria 2344V@1762,2F5RB@1,2GMGC@201174,33YA7@2 NA|NA|NA S SnoaL-like domain OLIIENHM_03687 1150599.MPHLEI_26036 1.7e-137 495.7 Mycobacteriaceae dfrA 1.1.1.219 ko:K00091 ko00000,ko01000 Bacteria 23297@1762,2GN90@201174,COG0451@1,COG0451@2 NA|NA|NA GM epimerase dehydratase OLIIENHM_03688 931627.MycrhDRAFT_3918 2.2e-172 612.1 Mycobacteriaceae Bacteria 232NV@1762,2GU7G@201174,COG1403@1,COG1403@2 NA|NA|NA V Domain of unknown function (DUF222) OLIIENHM_03690 164757.Mjls_4540 7.9e-89 333.2 Mycobacteriaceae Bacteria 239DT@1762,2IHX0@201174,COG5654@1,COG5654@2 NA|NA|NA S RES OLIIENHM_03691 1075090.GOAMR_06_01020 2.4e-196 691.4 Actinobacteria 2.1.1.72 ko:K00571 ko00000,ko01000,ko02048 Bacteria 2DB9A@1,2ICCG@201174,2Z7VI@2 NA|NA|NA S Adenine-specific methyltransferase EcoRI OLIIENHM_03692 1043205.AFYF01000099_gene626 1.6e-197 695.3 Intrasporangiaceae 2.3.1.51 ko:K00655,ko:K07451 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004,ko02048 Bacteria 2HNIA@201174,4FI35@85021,COG1403@1,COG1403@2,COG1479@1,COG1479@2 NA|NA|NA V Protein of unknown function DUF262 OLIIENHM_03693 931627.MycrhDRAFT_6992 9.4e-304 1050.0 Mycobacteriaceae Bacteria 234J5@1762,2GJRK@201174,COG0507@1,COG0507@2 NA|NA|NA L PFAM TrwC relaxase OLIIENHM_03694 525368.HMPREF0591_1654 9.2e-79 300.8 Mycobacteriaceae Bacteria 236CD@1762,2EZBB@1,2GK74@201174,33SGQ@2 NA|NA|NA OLIIENHM_03696 318424.EU78_29195 9e-22 109.0 Mycobacteriaceae Bacteria 23B3C@1762,2BF6G@1,2IS9Q@201174,328YV@2 NA|NA|NA OLIIENHM_03698 1440774.Y900_030540 1.9e-106 392.1 Mycobacteriaceae Bacteria 23CCH@1762,2IADV@201174,COG1432@1,COG1432@2 NA|NA|NA S Conserved Protein OLIIENHM_03699 525368.HMPREF0591_1818 2.3e-21 107.8 Mycobacteriaceae Bacteria 23BWY@1762,2B3X0@1,2GXHX@201174,31WKY@2 NA|NA|NA OLIIENHM_03700 318424.EU78_29260 1.3e-83 315.8 Mycobacteriaceae parA ko:K03496 ko00000,ko03036,ko04812 Bacteria 23498@1762,2ICWE@201174,COG1192@1,COG1192@2 NA|NA|NA D CobQ/CobB/MinD/ParA nucleotide binding domain OLIIENHM_03701 1440774.Y900_030535 7.6e-27 125.9 Mycobacteriaceae Bacteria 23ASV@1762,2AYT5@1,2ISW2@201174,31QYF@2 NA|NA|NA OLIIENHM_03702 710696.Intca_2843 1.1e-45 189.9 Actinobacteria Bacteria 2EGIQ@1,2IBVG@201174,33AAX@2 NA|NA|NA OLIIENHM_03703 1440774.Y900_028255 1.7e-41 175.3 Mycobacteriaceae Bacteria 23B40@1762,2DSMY@1,2GS9Y@201174,33GQS@2 NA|NA|NA S Protein of unknown function (DUF3024) OLIIENHM_03704 1440774.Y900_030580 1.2e-71 276.2 Mycobacteriaceae Bacteria 2341T@1762,2HSUX@201174,COG1961@1,COG1961@2 NA|NA|NA L resolvase OLIIENHM_03705 350058.Mvan_3262 1.5e-114 419.1 Mycobacteriaceae yfbU GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716 ko:K09161 ko00000 Bacteria 23755@1762,2ID7G@201174,COG3013@1,COG3013@2 NA|NA|NA S YfbU domain OLIIENHM_03706 1147128.BAST_0114 3.2e-12 77.4 Bifidobacteriales Bacteria 2AYD3@1,2IS1Y@201174,31QFY@2,4D18T@85004 NA|NA|NA S Uncharacterized protein conserved in bacteria (DUF2188) OLIIENHM_03707 1150599.MPHLEI_13296 1.9e-55 222.2 Mycobacteriaceae gpmB 3.1.3.3,3.1.3.73 ko:K02226,ko:K22305 ko00260,ko00680,ko00860,ko01100,ko01120,ko01130,map00260,map00680,map00860,map01100,map01120,map01130 M00122 R00582,R04594,R11173 RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 23744@1762,2GMX5@201174,COG0406@1,COG0406@2 NA|NA|NA G PFAM Phosphoglycerate mutase OLIIENHM_03708 1209984.BN978_02935 3e-78 298.5 Mycobacteriaceae cbtA Bacteria 2339I@1762,2H6Y9@201174,COG5446@1,COG5446@2 NA|NA|NA S cobalt transporter OLIIENHM_03709 1440774.Y900_010665 4e-22 110.2 Mycobacteriaceae Bacteria 23B8V@1762,2E37M@1,2GQZR@201174,32Y7B@2 NA|NA|NA S Probable cobalt transporter subunit (CbtB) OLIIENHM_03710 350058.Mvan_3265 1.1e-104 386.3 Mycobacteriaceae istB Bacteria 234SX@1762,2H714@201174,COG1484@1,COG1484@2 NA|NA|NA L IstB-like ATP binding protein OLIIENHM_03711 350058.Mvan_3264 1.6e-208 732.3 Mycobacteriaceae Bacteria 2377M@1762,2GM4J@201174,COG4584@1,COG4584@2 NA|NA|NA L Transposase OLIIENHM_03713 164757.Mjls_4541 2.5e-53 214.5 Mycobacteriaceae Bacteria 239B3@1762,2AF64@1,2IKGJ@201174,3154Z@2 NA|NA|NA K Protein of unknown function (DUF2384) OLIIENHM_03715 487521.OCU_10400 8.1e-145 520.4 Mycobacteriaceae Bacteria 233ZQ@1762,2GJ8V@201174,COG2124@1,COG2124@2 NA|NA|NA Q cytochrome p450 OLIIENHM_03716 525368.HMPREF0591_3639 0.0 1228.8 Mycobacteriaceae GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 Bacteria 233DM@1762,2GIZ1@201174,COG2114@1,COG2114@2,COG2197@1,COG2197@2,COG3903@1,COG3903@2 NA|NA|NA K involved in signal transduction (via phosphorylation) involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites catalytic activity ATP a protein ADP a phosphoprotein OLIIENHM_03717 419947.MRA_0309 2.3e-18 98.2 Actinobacteria GO:0006417,GO:0008150,GO:0009889,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031328,GO:0032069,GO:0032074,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0043086,GO:0044092,GO:0045727,GO:0045934,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051247,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060700,GO:0060701,GO:0065007,GO:0065009,GO:0080090,GO:2000112 Bacteria 2EI9R@1,2GWXW@201174,33C13@2 NA|NA|NA OLIIENHM_03718 419947.MRA_0310 2.7e-49 201.4 Mycobacteriaceae GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:2000112,GO:2000113 Bacteria 23ADN@1762,2IMGJ@201174,COG1487@1,COG1487@2 NA|NA|NA S Toxic component of a toxin-antitoxin (TA) module. An RNase OLIIENHM_03719 395964.KE386496_gene361 5.7e-103 381.7 Beijerinckiaceae 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 Bacteria 1MU62@1224,2TTSQ@28211,3NCIH@45404,COG0043@1,COG0043@2 NA|NA|NA H 3-octaprenyl-4-hydroxybenzoate carboxy-lyase OLIIENHM_03720 639283.Snov_1275 1.2e-17 96.3 Alphaproteobacteria Bacteria 1RJ9N@1224,2UJIT@28211,COG3832@1,COG3832@2 NA|NA|NA S Activator of Hsp90 ATPase homolog 1-like protein OLIIENHM_03721 1206741.BAFX01000074_gene4286 4.6e-68 264.2 Nocardiaceae ubiX GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0044237,GO:0044249,GO:0051186,GO:0051188 2.5.1.129 ko:K03186 ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 M00117 R01238,R02952,R03367,R04985,R04986,R11225 RC00391,RC00814,RC03392 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKID@201174,4G2MP@85025,COG0163@1,COG0163@2 NA|NA|NA H Flavoprotein OLIIENHM_03722 1038858.AXBA01000018_gene1234 4e-29 134.8 Bacteria Bacteria COG5589@1,COG5589@2 NA|NA|NA S Protein of unknown function (DUF2390) OLIIENHM_03723 931627.MycrhDRAFT_1964 4.2e-41 174.1 Mycobacteriaceae atfA1 2.3.1.20 ko:K00635 ko00561,ko01100,map00561,map01100 M00089 R02251 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 Bacteria 23298@1762,2GPHZ@201174,COG1020@1,COG1020@2 NA|NA|NA I Belongs to the long-chain O-acyltransferase family OLIIENHM_03725 251229.Chro_3846 1.1e-47 196.4 Cyanobacteria Bacteria 1G62J@1117,2AQX7@1,31G5S@2 NA|NA|NA OLIIENHM_03726 882086.SacxiDRAFT_3966 2.3e-25 122.5 Actinobacteria Bacteria 2IN76@201174,COG1309@1,COG1309@2 NA|NA|NA K Pfam Bacterial regulatory proteins, tetR family OLIIENHM_03727 1463901.JOIY01000071_gene1426 9.6e-47 193.4 Actinobacteria 4.1.1.46 ko:K07045,ko:K14333 ko00362,ko00627,ko01120,map00362,map00627,map01120 R00821 RC00390 ko00000,ko00001,ko01000 Bacteria 2HEB4@201174,COG2159@1,COG2159@2 NA|NA|NA CH amidohydrolase OLIIENHM_03729 547163.BN979_05049 1.3e-22 112.5 Mycobacteriaceae Bacteria 23A97@1762,2AD2H@1,2INAD@201174,312QR@2 NA|NA|NA OLIIENHM_03730 1370125.AUWT01000005_gene3146 6.9e-39 167.9 Mycobacteriaceae Bacteria 234TP@1762,2AN4C@1,2IDGP@201174,3133Z@2 NA|NA|NA OLIIENHM_03731 10224.XP_002741514.2 1.4e-70 273.5 Bilateria Metazoa 2QQW3@2759,39CED@33154,3BNHA@33208,3D3PB@33213,COG2230@1 NA|NA|NA M (S)-coclaurine N-methyltransferase-like OLIIENHM_03732 931627.MycrhDRAFT_2252 5.2e-138 497.3 Mycobacteriaceae Bacteria 233D3@1762,2HN3U@201174,COG0596@1,COG0596@2 NA|NA|NA E Alpha beta hydrolase OLIIENHM_03733 1440774.Y900_013170 3.7e-132 477.6 Mycobacteriaceae Bacteria 236QF@1762,2GPA5@201174,COG2141@1,COG2141@2 NA|NA|NA C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases OLIIENHM_03734 164757.Mjls_5761 9.3e-48 196.4 Mycobacteriaceae uspR Bacteria 239A3@1762,2GSWE@201174,COG1846@1,COG1846@2 NA|NA|NA K transcriptional OLIIENHM_03735 931627.MycrhDRAFT_2260 4.8e-233 813.5 Mycobacteriaceae ygjK GO:0003674,GO:0003824,GO:0004553,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0015926,GO:0016787,GO:0016798,GO:0033554,GO:0050896,GO:0051716 ko:K03931 ko00000 GH63 Bacteria 235P1@1762,2I1MU@201174,COG1626@1,COG1626@2 NA|NA|NA G glycogen debranching OLIIENHM_03736 1440774.Y900_013205 3.6e-96 357.8 Mycobacteriaceae Bacteria 233VT@1762,2GKK7@201174,COG4221@1,COG4221@2 NA|NA|NA S Belongs to the short-chain dehydrogenases reductases (SDR) family OLIIENHM_03737 1440774.Y900_013210 0.0 1718.0 Mycobacteriaceae leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 Bacteria 23584@1762,2GJI1@201174,COG0495@1,COG0495@2 NA|NA|NA J Belongs to the class-I aminoacyl-tRNA synthetase family OLIIENHM_03738 931627.MycrhDRAFT_2264 4.9e-80 304.7 Mycobacteriaceae mtc28 GO:0005575,GO:0005576 Bacteria 236Q8@1762,2APGE@1,2GMF1@201174,31EJ8@2 NA|NA|NA S Probable lipoprotein LpqN OLIIENHM_03739 931627.MycrhDRAFT_2265 4.3e-29 134.0 Mycobacteriaceae Bacteria 23AWK@1762,2BG6T@1,2IR6A@201174,32A3P@2 NA|NA|NA OLIIENHM_03740 1440774.Y900_013230 3.5e-101 374.4 Mycobacteriaceae GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K07735 ko00000,ko03000 Bacteria 234KC@1762,2GNRA@201174,COG1678@1,COG1678@2 NA|NA|NA K Belongs to the UPF0301 (AlgH) family OLIIENHM_03741 931627.MycrhDRAFT_2267 3.7e-174 617.8 Mycobacteriaceae 2.7.4.9 ko:K00943,ko:K08217 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 br01600,ko00000,ko00001,ko00002,ko01000,ko01504,ko02000 2.A.1.21.1,2.A.1.21.22 Bacteria 2361B@1762,2GK5A@201174,COG2270@1,COG2270@2 NA|NA|NA S Major facilitator superfamily OLIIENHM_03742 350058.Mvan_6059 3.4e-106 391.3 Mycobacteriaceae GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 Bacteria 235MK@1762,28HG7@1,2GMJK@201174,2Z7S3@2 NA|NA|NA S Wyosine base formation OLIIENHM_03743 1194972.MVAC_20743 3.4e-26 124.8 Mycobacteriaceae Bacteria 23A84@1762,2ETCM@1,2IM1F@201174,33KWG@2 NA|NA|NA OLIIENHM_03744 1440774.Y900_013260 3.9e-228 797.3 Mycobacteriaceae cca 2.7.7.19,2.7.7.72 ko:K00970,ko:K00974 ko03013,ko03018,map03013,map03018 R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016,ko03019 Bacteria 2328W@1762,2GMT1@201174,COG0617@1,COG0617@2 NA|NA|NA J poly(A) polymerase OLIIENHM_03745 1440774.Y900_013265 4e-77 294.3 Mycobacteriaceae deoC 3.6.1.13,3.6.1.17,3.6.1.55,3.6.1.61 ko:K01515,ko:K01518,ko:K03574,ko:K18445 ko00230,ko00240,map00230,map00240 R00184,R00969,R01054,R01232,R02805 RC00002 ko00000,ko00001,ko01000,ko03400 Bacteria 234KT@1762,2GWEB@201174,COG0494@1,COG0494@2 NA|NA|NA L Belongs to the NUDIX hydrolase family OLIIENHM_03746 931627.MycrhDRAFT_2274 4.7e-289 1000.3 Mycobacteriaceae Bacteria 2354M@1762,2DUHC@1,2I46X@201174,33QN2@2 NA|NA|NA OLIIENHM_03747 931627.MycrhDRAFT_2275 0.0 1431.8 Mycobacteriaceae murJ GO:0003674,GO:0005215,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0008150,GO:0015238,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0042221,GO:0042493,GO:0042891,GO:0042895,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944 ko:K03980 ko00000,ko01011,ko02000 2.A.66.4 Bacteria 234X0@1762,2GKN0@201174,COG0728@1,COG0728@2 NA|NA|NA S Integral membrane protein MviN OLIIENHM_03748 931627.MycrhDRAFT_2276 6.4e-57 227.3 Mycobacteriaceae sigM GO:0001101,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009410,GO:0009415,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010035,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042221,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1901700,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 ko:K03088 ko00000,ko03021 Bacteria 234S9@1762,2GJMX@201174,COG1595@1,COG1595@2 NA|NA|NA K Belongs to the sigma-70 factor family. ECF subfamily OLIIENHM_03749 1380391.JIAS01000011_gene5510 1.3e-183 649.4 Rhodospirillales ko:K06978 ko00000 Bacteria 1MVA8@1224,2JRBF@204441,2TU0R@28211,COG2936@1,COG2936@2 NA|NA|NA S X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain OLIIENHM_03750 526226.Gbro_2584 4.1e-235 820.8 Gordoniaceae ko:K03733,ko:K04763 ko00000,ko03036 Bacteria 2IBD6@201174,4GFSJ@85026,COG4974@1,COG4974@2 NA|NA|NA L PFAM integrase family protein OLIIENHM_03751 526226.Gbro_2585 5.7e-138 497.3 Gordoniaceae Bacteria 2I9ZX@201174,4GFWP@85026,COG4974@1,COG4974@2 NA|NA|NA L integrase domain protein SAM domain protein OLIIENHM_03752 110319.CF8_4229 2.8e-132 478.4 Actinobacteria ko:K07497 ko00000 Bacteria 2GKDY@201174,COG2801@1,COG2801@2 NA|NA|NA L PFAM Integrase catalytic OLIIENHM_03753 478801.Ksed_22920 1.4e-122 445.7 Actinobacteria insI1 GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004803,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0030983,GO:0032135,GO:0032196,GO:0032991,GO:0032993,GO:0034641,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 ko:K07482 ko00000 Bacteria 2GMZX@201174,COG2826@1,COG2826@2 NA|NA|NA L Transposase and inactivated derivatives IS30 family OLIIENHM_03754 931627.MycrhDRAFT_3545 3e-52 211.5 Mycobacteriaceae rpsC GO:0000028,GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02982 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2330J@1762,2GKF1@201174,COG0092@1,COG0092@2 NA|NA|NA J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation OLIIENHM_03755 710421.Mycch_0952 2.6e-73 281.2 Mycobacteriaceae rplP GO:0000027,GO:0000049,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02878 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 238MK@1762,2IFEI@201174,COG0197@1,COG0197@2 NA|NA|NA J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs OLIIENHM_03756 931627.MycrhDRAFT_3547 1e-29 135.6 Mycobacteriaceae rpmC GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02904 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 23AK9@1762,2IQ6V@201174,COG0255@1,COG0255@2 NA|NA|NA J Belongs to the universal ribosomal protein uL29 family OLIIENHM_03757 1370125.AUWT01000024_gene5455 2.8e-40 171.0 Mycobacteriaceae rpsQ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02961 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 239XV@1762,2IQ68@201174,COG0186@1,COG0186@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA OLIIENHM_03758 710685.MycrhN_4073 9.9e-68 265.4 Mycobacteriaceae 3.1.3.3 ko:K07315,ko:K20971 ko02025,map02025 ko00000,ko00001,ko01000,ko01001,ko02022,ko03021 Bacteria 23FCK@1762,2I43Y@201174,COG2208@1,COG2208@2,COG4251@1,COG4251@2 NA|NA|NA T GAF domain OLIIENHM_03759 164757.Mjls_0395 1.8e-26 125.6 Mycobacteriaceae ko:K04749 ko00000,ko03021 Bacteria 23AHV@1762,2I19W@201174,COG1366@1,COG1366@2 NA|NA|NA T Belongs to the anti-sigma-factor antagonist family OLIIENHM_03760 350058.Mvan_0550 4e-218 763.8 Mycobacteriaceae ko:K07493 ko00000 Bacteria 234FU@1762,2GM8F@201174,COG3328@1,COG3328@2 NA|NA|NA L Transposase, mutator OLIIENHM_03762 44454.NF84_20240 9.2e-83 313.2 Mycobacteriaceae rmlC GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008830,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016853,GO:0016854,GO:0016857,GO:0018130,GO:0019305,GO:0019438,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576 5.1.3.13,5.1.3.27 ko:K01790,ko:K13312,ko:K13316,ko:K16438 ko00404,ko00521,ko00523,ko01055,ko01130,map00404,map00521,map00523,map01055,map01130 M00793,M00794,M00798,M00799,M00800 R06433,R06437,R06514,R06628,R08934,R11046,R11138 RC01518,RC01519,RC01531 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv3465 Bacteria 233JG@1762,2GMW4@201174,COG1898@1,COG1898@2 NA|NA|NA M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose OLIIENHM_03763 1440774.Y900_007745 5.6e-128 463.8 Mycobacteriaceae rfbB GO:0000166,GO:0000271,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008460,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019305,GO:0019438,GO:0030312,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044464,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0048037,GO:0050662,GO:0051287,GO:0055086,GO:0070404,GO:0071704,GO:0071944,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv3464 Bacteria 233QD@1762,2GNDU@201174,COG1088@1,COG1088@2 NA|NA|NA M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily OLIIENHM_03764 419947.MRA_1991 5.2e-76 290.8 Mycobacteriaceae mpt64 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0019899,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0035375,GO:0042594,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:0071944 Bacteria 23F0D@1762,28KR0@1,2GSFZ@201174,2ZA8P@2 NA|NA|NA S Protein of unknown function (DUF3298) OLIIENHM_03765 1183438.GKIL_0150 7.7e-122 444.1 Cyanobacteria merA GO:0000302,GO:0000305,GO:0001101,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016491,GO:0016667,GO:0019725,GO:0042221,GO:0042592,GO:0044424,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901530,GO:1901700,GO:1990748 1.16.1.1,1.8.1.7 ko:K00383,ko:K00520,ko:K21739 ko00480,ko04918,map00480,map04918 R00094,R00115 RC00011 ko00000,ko00001,ko01000 Bacteria 1G498@1117,COG1249@1,COG1249@2 NA|NA|NA C Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain OLIIENHM_03766 1229780.BN381_150078 1.1e-25 124.0 Actinobacteria Bacteria 2DPD0@1,2IFZU@201174,331J4@2 NA|NA|NA OLIIENHM_03767 557599.MKAN_01145 4.4e-78 297.7 Mycobacteriaceae citB ko:K02475,ko:K11615 ko02020,map02020 M00490 ko00000,ko00001,ko00002,ko02022 Bacteria 233PP@1762,2GK16@201174,COG4565@1,COG4565@2 NA|NA|NA KT transcriptional regulatory protein OLIIENHM_03768 1370121.AUWS01000071_gene127 1.7e-200 705.7 Mycobacteriaceae citA 2.7.13.3 ko:K02476 ko00000,ko01000,ko01001,ko02022 Bacteria 237JN@1762,2GIRZ@201174,COG3290@1,COG3290@2 NA|NA|NA T Signal transduction histidine kinase regulating citrate malate metabolism OLIIENHM_03769 710685.MycrhN_2273 1.6e-138 499.6 Mycobacteriaceae pvdL Bacteria 232PE@1762,2GSQU@201174,COG1020@1,COG1020@2 NA|NA|NA Q COG1020 Non-ribosomal peptide synthetase modules and related proteins OLIIENHM_03770 644283.Micau_2565 1.3e-06 60.8 Micromonosporales Bacteria 2B1XT@1,2GTW5@201174,31UE4@2,4DFSE@85008 NA|NA|NA OLIIENHM_03772 350058.Mvan_1952 2.4e-37 161.0 Mycobacteriaceae Bacteria 23AMM@1762,2CC0C@1,2IQSF@201174,32ZJ1@2 NA|NA|NA S Protein of unknown function (DUF3297) OLIIENHM_03773 1146883.BLASA_2186 2.2e-10 72.0 Actinobacteria Bacteria 2H0F6@201174,COG4634@1,COG4634@2 NA|NA|NA OLIIENHM_03774 526225.Gobs_3728 8.9e-13 80.1 Frankiales Bacteria 2E73E@1,2IRHV@201174,331MX@2,4EVZR@85013 NA|NA|NA OLIIENHM_03776 931627.MycrhDRAFT_1529 1.8e-170 605.5 Mycobacteriaceae blt Bacteria 234ZV@1762,2GK1K@201174,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily OLIIENHM_03777 1110697.NCAST_08_01290 3.7e-12 77.8 Nocardiaceae Bacteria 2E9A0@1,2HSBR@201174,333I1@2,4G3FA@85025 NA|NA|NA S Domain of unknown function (DUF4333) OLIIENHM_03778 931627.MycrhDRAFT_1528 1.5e-284 984.9 Mycobacteriaceae pgm GO:0000271,GO:0003674,GO:0003824,GO:0004614,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0005996,GO:0006006,GO:0006012,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0016868,GO:0019318,GO:0019320,GO:0019388,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0055114,GO:0071704,GO:1901575,GO:1901576 5.4.2.2 ko:K01835 ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00549 R00959,R01057,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 iAPECO1_1312.APECO1_1376,iECED1_1282.ECED1_0670,iECNA114_1301.ECNA114_0627,iECOK1_1307.ECOK1_0699,iECP_1309.ECP_0709,iECS88_1305.ECS88_0725,iJN678.pgm,iLF82_1304.LF82_1632,iNRG857_1313.NRG857_03110,iUMN146_1321.UM146_14115,iYL1228.KPN_00711 Bacteria 235C4@1762,2H1PI@201174,COG0033@1,COG0033@2 NA|NA|NA G Phosphoglucomutase OLIIENHM_03779 931627.MycrhDRAFT_1527 2.5e-50 204.9 Mycobacteriaceae crcB1 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 ko:K06199 ko00000,ko02000 1.A.43.1,1.A.43.2,1.A.43.3 Bacteria 2396M@1762,2IKM1@201174,COG0239@1,COG0239@2 NA|NA|NA D Important for reducing fluoride concentration in the cell, thus reducing its toxicity OLIIENHM_03780 1440774.Y900_005285 4.4e-43 180.6 Mycobacteriaceae crcB GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 ko:K06199 ko00000,ko02000 1.A.43.1,1.A.43.2,1.A.43.3 Bacteria 23A0Y@1762,2IKWG@201174,COG0239@1,COG0239@2 NA|NA|NA D Important for reducing fluoride concentration in the cell, thus reducing its toxicity OLIIENHM_03781 931627.MycrhDRAFT_1525 1.3e-119 436.4 Mycobacteriaceae ko:K09137 ko00000 Bacteria 2348U@1762,2IM7J@201174,COG1993@1,COG1993@2 NA|NA|NA S Uncharacterized ACR, COG1993 OLIIENHM_03782 931627.MycrhDRAFT_1524 9.9e-34 149.4 Mycobacteriaceae Bacteria 2396F@1762,2IQI4@201174,COG1917@1,COG1917@2 NA|NA|NA S conserved protein, contains double-stranded beta-helix domain OLIIENHM_03783 931627.MycrhDRAFT_1523 6.6e-43 180.3 Mycobacteriaceae Bacteria 239WQ@1762,2E3RQ@1,2IKMN@201174,32YPC@2 NA|NA|NA OLIIENHM_03784 1299327.I546_3547 2.6e-38 165.2 Mycobacteriaceae lppN Bacteria 2397G@1762,29VFP@1,2IJ9V@201174,30GWZ@2 NA|NA|NA OLIIENHM_03785 547163.BN979_05904 4.5e-158 565.5 Mycobacteriaceae Bacteria 2343H@1762,2I5V8@201174,COG1506@1,COG1506@2 NA|NA|NA E peptidase S15 OLIIENHM_03786 258533.BN977_05223 2.4e-60 238.0 Mycobacteriaceae ko:K09966 ko00000 Bacteria 2396K@1762,2IHNI@201174,COG3651@1,COG3651@2 NA|NA|NA S protein conserved in bacteria OLIIENHM_03787 350058.Mvan_5862 1.2e-201 709.1 Mycobacteriaceae Bacteria 2387P@1762,2GNBV@201174,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily OLIIENHM_03788 710685.MycrhN_2866 6e-49 200.7 Mycobacteriaceae Bacteria 237JT@1762,2EB70@1,2I9PW@201174,3357M@2 NA|NA|NA OLIIENHM_03790 251229.Chro_3846 6.3e-48 197.2 Cyanobacteria Bacteria 1G62J@1117,2AQX7@1,31G5S@2 NA|NA|NA OLIIENHM_03791 1370121.AUWS01000010_gene5887 7.7e-66 256.9 Mycobacteriaceae betI7 GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141 Bacteria 236P4@1762,2GRIJ@201174,COG1309@1,COG1309@2 NA|NA|NA K tetR family OLIIENHM_03792 931627.MycrhDRAFT_1772 5.3e-61 240.7 Mycobacteriaceae Bacteria 235U3@1762,2GMA7@201174,COG0431@1,COG0431@2 NA|NA|NA S FMN reductase OLIIENHM_03793 350058.Mvan_0147 5e-107 394.0 Mycobacteriaceae GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 ko:K06911 ko00000 Bacteria 23325@1762,2GJV3@201174,COG1741@1,COG1741@2 NA|NA|NA S Belongs to the pirin family OLIIENHM_03794 1110697.NCAST_34_00980 5.6e-55 220.3 Nocardiaceae arsC 1.20.4.1 ko:K03741 ko00000,ko01000 Bacteria 2IHR3@201174,4G196@85025,COG0394@1,COG0394@2 NA|NA|NA T Belongs to the low molecular weight phosphotyrosine protein phosphatase family OLIIENHM_03795 1341646.CBMO010000126_gene2776 1.8e-111 408.7 Mycobacteriaceae arsB GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015104,GO:0015105,GO:0015291,GO:0015297,GO:0015318,GO:0015698,GO:0015699,GO:0015700,GO:0016020,GO:0022804,GO:0022857,GO:0034220,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656 1.20.4.1 ko:K03325,ko:K03741 ko00000,ko01000,ko02000 2.A.59 iYO844.BSU25790 Bacteria 232N0@1762,2GJ4H@201174,COG0798@1,COG0798@2 NA|NA|NA P arsenical-resistance protein OLIIENHM_03796 1440774.Y900_000640 1.1e-271 942.2 Mycobacteriaceae mutB GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016999,GO:0017144,GO:0019541,GO:0019678,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044464,GO:0046459,GO:0071704,GO:0071944 5.4.99.2 ko:K01847 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 Bacteria 2342H@1762,2I2N3@201174,COG2185@1,COG2185@2 NA|NA|NA I Methylmalonyl-CoA mutase OLIIENHM_03797 1370121.AUWS01000008_gene5745 8.4e-150 536.6 Mycobacteriaceae argK GO:0003674,GO:0003824,GO:0003924,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111 ko:K07588 ko00000,ko01000 Bacteria 232AG@1762,2GME8@201174,COG1703@1,COG1703@2 NA|NA|NA E LAO AO transport system ATPase OLIIENHM_03798 1440774.Y900_000630 4.3e-188 664.1 Mycobacteriaceae lipL Bacteria 233VV@1762,2GJJB@201174,COG1680@1,COG1680@2 NA|NA|NA V beta-lactamase OLIIENHM_03799 1435356.Y013_19425 3.6e-22 110.5 Nocardiaceae ko:K00666 ko00000,ko01000,ko01004 Bacteria 2GJAA@201174,4FUI3@85025,COG0318@1,COG0318@2 NA|NA|NA IQ AMP-binding enzyme C-terminal domain OLIIENHM_03800 1033736.CAHK01000049_gene1918 2.5e-78 298.9 Actinobacteria Bacteria 2GK20@201174,COG1028@1,COG1028@2 NA|NA|NA IQ Short-chain dehydrogenase reductase sdr OLIIENHM_03801 1380386.JIAW01000001_gene4492 4.9e-178 630.6 Mycobacteriaceae acdA ko:K18244 ko00000,ko01000 Bacteria 233Z5@1762,2GIX8@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_03802 931627.MycrhDRAFT_0637 5.2e-271 939.9 Mycobacteriaceae accD2 6.4.1.4,6.4.1.5 ko:K01969,ko:K13778 ko00280,ko00281,ko01100,map00280,map00281,map01100 M00036 R03494,R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 Bacteria 2329Y@1762,2GIRU@201174,COG4799@1,COG4799@2 NA|NA|NA I Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) OLIIENHM_03803 525368.HMPREF0591_4785 5.8e-187 660.2 Mycobacteriaceae fadE13 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 Bacteria 236F2@1762,2GVSU@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase OLIIENHM_03804 525368.HMPREF0591_4786 9.6e-263 912.5 Mycobacteriaceae Bacteria 2345S@1762,2GJNC@201174,COG3185@1,COG3185@2 NA|NA|NA E Acyclic terpene utilisation family protein AtuA OLIIENHM_03805 931627.MycrhDRAFT_3528 3.5e-194 684.5 Mycobacteriaceae mftF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 Bacteria 2342F@1762,2HN9A@201174,COG1216@1,COG1216@2 NA|NA|NA M Glycosyl transferase family 2 # 3498 queries scanned # Total time (seconds): 59.2463021278 # Rate: 59.04 q/s