# emapper version: emapper-2.0.1 emapper DB: 2.0 # command: ./emapper.py -m diamond --seed_ortholog_evalue 0.00001 --data_dir /home/bayegy/Databases/emapper/data_dir2.0.1/ --cpu 45 --temp_dir /media/bayegy/disk0/binning_test/Bin_all/emapper//bin.T11.34/_tmp -i /media/bayegy/disk0/binning_test/Bin_all/Bin_prokka//bin.T11.34/bin.T11.34.faa -o /media/bayegy/disk0/binning_test/Bin_all/emapper//bin.T11.34/bin.T11.34 --usemem --override # time: Wed Nov 3 20:18:09 2021 #query_name seed_eggNOG_ortholog seed_ortholog_evalue seed_ortholog_score best_tax_level Preferred_name GOs EC KEGG_ko KEGG_Pathway KEGG_Module KEGG_Reaction KEGG_rclass BRITE KEGG_TC CAZy BiGG_Reaction taxonomic scope eggNOG OGs best eggNOG OG COG Functional cat. eggNOG free text desc. HIMHAPGP_00002 1234595.C725_2174 6.7e-179 634.4 unclassified Alphaproteobacteria iorB2 1.3.99.16 ko:K07303 ko00000,ko01000 Bacteria 1QTTJ@1224,2TQVK@28211,4BR9M@82117,COG1529@1,COG1529@2 NA|NA|NA C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain HIMHAPGP_00003 1090318.ATTI01000001_gene2737 1.7e-97 362.8 Sphingomonadales hemH GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 Bacteria 1MVR1@1224,2K0NQ@204457,2TSMS@28211,COG0276@1,COG0276@2 NA|NA|NA H Catalyzes the ferrous insertion into protoporphyrin IX HIMHAPGP_00004 1549858.MC45_13895 2.4e-106 391.7 Sphingomonadales Bacteria 1MUEV@1224,2K0A2@204457,2TRCF@28211,COG1028@1,COG1028@2 NA|NA|NA IQ Acetoacetyl-CoA reductase HIMHAPGP_00005 1112216.JH594425_gene1586 3.4e-38 164.9 Sphingomonadales nudF 3.6.1.13 ko:K01515 ko00230,map00230 R01054 RC00002 ko00000,ko00001,ko01000 Bacteria 1RE72@1224,2K4H0@204457,2U805@28211,COG0494@1,COG0494@2 NA|NA|NA L Nudix hydrolase HIMHAPGP_00006 1206733.BAGC01000003_gene6070 1.6e-166 592.4 Nocardiaceae 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 Bacteria 2GKQI@201174,4FUXI@85025,COG1960@1,COG1960@2 NA|NA|NA I Acyl-CoA dehydrogenase, C-terminal domain HIMHAPGP_00007 1248916.ANFY01000007_gene2435 1.5e-53 216.9 Sphingomonadales Bacteria 1MWAK@1224,2K142@204457,2TT2N@28211,COG3173@1,COG3173@2 NA|NA|NA S Aminoglycoside phosphotransferase HIMHAPGP_00008 1030157.AFMP01000062_gene3491 1.1e-154 553.1 Sphingomonadales valS GO:0000287,GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006438,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045903,GO:0046483,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0061475,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:2000112 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iECH74115_1262.ECH74115_5779,iECNA114_1301.ECNA114_4481,iECO26_1355.ECO26_5428,iECSP_1301.ECSP_5359,iECs_1301.ECs5235,iG2583_1286.G2583_5088,iJN746.PP_0977,iSBO_1134.SBO_4182,iSSON_1240.SSON_4443,iYL1228.KPN_04663,iZ_1308.Z5870 Bacteria 1MV7B@1224,2K0N3@204457,2TS9E@28211,COG0525@1,COG0525@2 NA|NA|NA J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner HIMHAPGP_00009 1198452.Jab_1c09580 1.7e-46 192.6 Proteobacteria Bacteria 1P3UV@1224,2APX0@1,31F1M@2 NA|NA|NA S PEP-CTERM motif HIMHAPGP_00010 1123240.ATVO01000007_gene2204 1.3e-134 486.5 Sphingomonadales Bacteria 1MU48@1224,2KCZ7@204457,2TQT0@28211,COG0841@1,COG0841@2 NA|NA|NA V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family HIMHAPGP_00012 1007104.SUS17_2942 7.5e-10 70.1 Sphingomonadales rpsE GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990145,GO:1990904 ko:K02988 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1MUS4@1224,2K10Y@204457,2TSRI@28211,COG0098@1,COG0098@2 NA|NA|NA J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body HIMHAPGP_00013 392499.Swit_1337 1.7e-41 175.3 Sphingomonadales rplR GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02881 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1RGY7@1224,2K52X@204457,2U9A6@28211,COG0256@1,COG0256@2 NA|NA|NA J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance HIMHAPGP_00014 1248916.ANFY01000003_gene883 1e-77 296.2 Sphingomonadales rplF GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02933 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1R9YZ@1224,2K149@204457,2TV09@28211,COG0097@1,COG0097@2 NA|NA|NA J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center HIMHAPGP_00015 1007104.SUS17_2945 1.2e-54 219.2 Sphingomonadales rpsH GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009894,GO:0009987,GO:0010467,GO:0010468,GO:0010608,GO:0015935,GO:0016043,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031323,GO:0031329,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043487,GO:0043488,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0061013,GO:0065003,GO:0065007,GO:0065008,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903311,GO:1990904 ko:K02994 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1RDG3@1224,2K3ZU@204457,2U6ZH@28211,COG0096@1,COG0096@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit HIMHAPGP_00016 629773.AORY01000004_gene527 2.8e-40 171.0 Sphingomonadales rpsN GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02954 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1MZDT@1224,2K53G@204457,2UC01@28211,COG0199@1,COG0199@2 NA|NA|NA J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site HIMHAPGP_00017 555793.WSK_0542 7.6e-44 183.0 Sphingomonadales rplE GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02931 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1MUU9@1224,2K0S5@204457,2TQPF@28211,COG0094@1,COG0094@2 NA|NA|NA J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HIMHAPGP_00018 1116369.KB890024_gene2471 7.4e-51 207.2 Proteobacteria Bacteria 1N90Y@1224,COG4782@1,COG4782@2 NA|NA|NA S Alpha/beta hydrolase of unknown function (DUF900) HIMHAPGP_00019 1230476.C207_00563 3.7e-42 178.3 Bradyrhizobiaceae ko:K07002 ko00000 Bacteria 1N2W0@1224,2U0MD@28211,3JT71@41294,COG1075@1,COG1075@2 NA|NA|NA S acetyltransferases and hydrolases with the alpha beta hydrolase fold HIMHAPGP_00020 392499.Swit_0027 5.5e-230 803.9 Sphingomonadales Bacteria 1MUJ3@1224,2K2WB@204457,2TUBW@28211,COG0823@1,COG0823@2,COG1506@1,COG1506@2 NA|NA|NA EU Dienelactone hydrolase family HIMHAPGP_00021 450851.PHZ_c0713 8.1e-183 647.1 Caulobacterales Bacteria 1MUBX@1224,2KFHK@204458,2TSUQ@28211,COG4805@1,COG4805@2 NA|NA|NA S Bacterial protein of unknown function (DUF885) HIMHAPGP_00022 1331060.RLDS_13310 1.1e-94 352.8 Sphingomonadales cysK 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUBE@1224,2K2A3@204457,2TS33@28211,COG0031@1,COG0031@2 NA|NA|NA E Belongs to the cysteine synthase cystathionine beta- synthase family HIMHAPGP_00023 1248916.ANFY01000003_gene1041 2.6e-38 166.0 Sphingomonadales ykuE ko:K07098 ko00000 Bacteria 1MUH5@1224,2K3YY@204457,2TVHN@28211,COG1408@1,COG1408@2 NA|NA|NA S Calcineurin-like phosphoesterase HIMHAPGP_00024 59538.XP_005977964.1 6.1e-134 483.8 Bilateria Metazoa 38CDB@33154,3BCJG@33208,3CU6J@33213,COG1012@1,KOG2450@2759 NA|NA|NA C aldehyde dehydrogenase (NAD) activity HIMHAPGP_00025 392499.Swit_3857 6.5e-209 733.8 Sphingomonadales ko:K02014 ko00000,ko02000 1.B.14 Bacteria 1MWKN@1224,2K075@204457,2TTFY@28211,COG1629@1,COG4771@2 NA|NA|NA P receptor HIMHAPGP_00028 1123240.ATVO01000006_gene1351 3e-38 165.2 Sphingomonadales rpoE5 ko:K03088 ko00000,ko03021 Bacteria 1MX7T@1224,2KD1V@204457,2U5A1@28211,COG1595@1,COG1595@2 NA|NA|NA K Sigma-70, region 4 HIMHAPGP_00029 1234595.C725_0898 5.6e-141 507.3 Alphaproteobacteria korB GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016625,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0030312,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046872,GO:0047553,GO:0055114,GO:0071704,GO:0071944,GO:0072350 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1R5BF@1224,2TR4R@28211,COG1013@1,COG1013@2 NA|NA|NA C COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit HIMHAPGP_00030 279238.Saro_1757 2.5e-264 917.9 Sphingomonadales korA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0030312,GO:0044464,GO:0050896,GO:0055114,GO:0071944 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1NBSJ@1224,2K2JW@204457,2TU21@28211,COG0674@1,COG0674@2,COG1014@1,COG1014@2 NA|NA|NA C COG1014 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, gamma subunit HIMHAPGP_00032 1123240.ATVO01000006_gene1529 8.2e-76 290.0 Sphingomonadales Bacteria 1QZ3D@1224,2KEPK@204457,2TY43@28211,COG0457@1,COG0457@2 NA|NA|NA S Putative 2OG-Fe(II) oxygenase HIMHAPGP_00033 471853.Bcav_2647 4.5e-17 94.0 Actinobacteria Bacteria 2E3QV@1,2GQQZ@201174,32YNP@2 NA|NA|NA S Domain of unknown function (DUF1905) HIMHAPGP_00034 1121013.P873_01375 1.8e-67 263.5 Xanthomonadales 3.4.21.102 ko:K03797 ko00000,ko01000,ko01002 Bacteria 1RGID@1224,1RYNU@1236,1X5PS@135614,COG0793@1,COG0793@2 NA|NA|NA M tail specific protease HIMHAPGP_00035 1449049.JONW01000003_gene2062 4.1e-153 548.1 Caulobacterales MA20_07830 ko:K10215 ko00627,ko01120,map00627,map01120 R07836,R07837 RC02100,RC03121 ko00000,ko00001,ko01000 Bacteria 1MU71@1224,2KG5Q@204458,2TV2E@28211,COG2072@1,COG2072@2 NA|NA|NA P Flavin-binding monooxygenase-like HIMHAPGP_00036 190650.CC_0755 1.3e-91 343.6 Caulobacterales pimC GO:0000009,GO:0000030,GO:0003674,GO:0003824,GO:0004376,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0033164,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0070085,GO:0071704,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509 ko:K14335 ko00000,ko01000,ko01003 GT4 Bacteria 1NU0D@1224,2KJRY@204458,2U2M4@28211,COG0438@1,COG0438@2 NA|NA|NA M Glycosyl transferase 4-like domain HIMHAPGP_00037 1090320.KB900605_gene930 4.3e-31 141.4 Sphingomonadales Bacteria 1RITF@1224,2K5C0@204457,2UAIQ@28211,COG4704@1,COG4704@2 NA|NA|NA S Uncharacterized protein conserved in bacteria (DUF2141) HIMHAPGP_00038 1007104.SUS17_3357 9.1e-40 171.0 Sphingomonadales Bacteria 1RE5R@1224,2EDGC@1,2K1JN@204457,2U8YS@28211,337CJ@2 NA|NA|NA HIMHAPGP_00039 1219035.NT2_02_04940 2.2e-35 154.5 Sphingomonadales pccB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016421,GO:0016874,GO:0016885,GO:0019752,GO:0031974,GO:0032787,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0070013,GO:0071704,GO:0072329,GO:1901575 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 Bacteria 1MVAX@1224,2K0V7@204457,2TRI1@28211,COG4799@1,COG4799@2 NA|NA|NA I acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) HIMHAPGP_00040 1123240.ATVO01000004_gene1092 2.7e-71 275.4 Sphingomonadales MA20_19830 Bacteria 1NHGB@1224,2AFUA@1,2JZXR@204457,2TQWW@28211,315WQ@2 NA|NA|NA S Putative transmembrane protein (Alph_Pro_TM) HIMHAPGP_00041 1123240.ATVO01000004_gene1093 5.8e-94 350.9 Sphingomonadales MA20_19835 ko:K07090 ko00000 Bacteria 1MWX2@1224,2K1QQ@204457,2TRIC@28211,COG0730@1,COG0730@2 NA|NA|NA S membrane transporter protein HIMHAPGP_00042 1121033.AUCF01000018_gene5806 3.4e-170 604.7 Rhodospirillales trmFO GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 2.1.1.74 ko:K04094 ko00000,ko01000,ko03016,ko03036 Bacteria 1MWNQ@1224,2JQ17@204441,2TR6M@28211,COG1206@1,COG1206@2 NA|NA|NA J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs HIMHAPGP_00043 1248916.ANFY01000002_gene1323 2.7e-41 175.6 Sphingomonadales Bacteria 1N7M7@1224,2K48N@204457,2UISJ@28211,COG0789@1,COG0789@2 NA|NA|NA K MerR HTH family regulatory protein HIMHAPGP_00044 1248916.ANFY01000009_gene191 1.6e-160 572.8 Sphingomonadales glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 Bacteria 1MUP7@1224,2K01R@204457,2TRD7@28211,COG0554@1,COG0554@2 NA|NA|NA C Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate HIMHAPGP_00045 1382303.JPOM01000001_gene1407 2.1e-79 302.4 Caulobacterales Bacteria 1MU3W@1224,2KGMQ@204458,2TT5X@28211,COG1028@1,COG1028@2 NA|NA|NA IQ KR domain HIMHAPGP_00046 1234595.C725_0622 6.8e-112 410.6 unclassified Alphaproteobacteria hemF GO:0003674,GO:0003824,GO:0004109,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016634,GO:0018130,GO:0019438,GO:0030145,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0046872,GO:0046906,GO:0046914,GO:0046983,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.3.3.3 ko:K00228 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03220 RC00884 ko00000,ko00001,ko00002,ko01000 iAF1260.b2436,iBWG_1329.BWG_2198,iECDH10B_1368.ECDH10B_2601,iECDH1ME8569_1439.ECDH1ME8569_2370,iETEC_1333.ETEC_2549,iEcDH1_1363.EcDH1_1225,iEcHS_1320.EcHS_A2573,iEcolC_1368.EcolC_1243,iJO1366.b2436,iJR904.b2436,iY75_1357.Y75_RS12760 Bacteria 1MWMF@1224,2TQNC@28211,4BPF5@82117,COG0408@1,COG0408@2 NA|NA|NA H Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX HIMHAPGP_00048 685035.ADAE01000018_gene609 1.9e-26 125.2 Sphingomonadales 4.2.99.21 ko:K04782 ko01053,ko01110,ko01130,map01053,map01110,map01130 R06602 RC01549,RC02148 ko00000,ko00001,ko01000 Bacteria 1PZD9@1224,2KDHZ@204457,2UD5B@28211,COG1605@1,COG1605@2 NA|NA|NA E Chorismate mutase type II HIMHAPGP_00050 1123240.ATVO01000003_gene514 2.3e-26 125.6 Sphingomonadales ygfA GO:0003674,GO:0003824,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019752,GO:0022611,GO:0030272,GO:0032502,GO:0034641,GO:0035999,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.2 ko:K01934 ko00670,ko01100,map00670,map01100 R02301 RC00183 ko00000,ko00001,ko01000 iECABU_c1320.ECABU_c31940,iECOK1_1307.ECOK1_3298,iECSF_1327.ECSF_2705,iUTI89_1310.UTI89_C3298 Bacteria 1MZG0@1224,2K6W9@204457,2UBY4@28211,COG0212@1,COG0212@2 NA|NA|NA H 5-formyltetrahydrofolate cyclo-ligase HIMHAPGP_00051 1123267.JONN01000001_gene1357 7.2e-13 80.1 Sphingomonadales zapA ko:K09888 ko00000,ko03036 Bacteria 1Q3M7@1224,2K78U@204457,2VACI@28211,COG3027@1,COG3027@2 NA|NA|NA D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division HIMHAPGP_00053 1545915.JROG01000003_gene788 1.1e-257 896.0 Sphingomonadales tkt 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUEY@1224,2K0UZ@204457,2TQUX@28211,COG0021@1,COG0021@2 NA|NA|NA G Belongs to the transketolase family HIMHAPGP_00054 1090320.KB900605_gene2257 4.5e-151 540.8 Sphingomonadales gapA GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 Bacteria 1MU93@1224,2K0GC@204457,2TR6E@28211,COG0057@1,COG0057@2 NA|NA|NA G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family HIMHAPGP_00055 983920.Y88_0713 1.5e-161 575.9 Sphingomonadales pgk GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1MUNU@1224,2K0JN@204457,2TSKQ@28211,COG0126@1,COG0126@2 NA|NA|NA F Belongs to the phosphoglycerate kinase family HIMHAPGP_00056 1030157.AFMP01000052_gene145 1.1e-145 522.7 Sphingomonadales fbaB 4.1.2.13 ko:K11645 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 Bacteria 1MW9N@1224,2JZV8@204457,2TSQD@28211,COG1830@1,COG1830@2 NA|NA|NA G DeoC/LacD family aldolase HIMHAPGP_00057 1335760.ASTG01000010_gene709 1.8e-63 249.2 Sphingomonadales thiE GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 Bacteria 1MV42@1224,2K16H@204457,2TSSA@28211,COG0352@1,COG0352@2 NA|NA|NA H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) HIMHAPGP_00058 1007104.SUS17_2177 2.2e-187 662.1 Sphingomonadales ko:K01269 ko00000,ko01000 Bacteria 1MV86@1224,2K04D@204457,2TVJ5@28211,COG2234@1,COG2234@2 NA|NA|NA S Peptidase, M28 HIMHAPGP_00059 1007104.SUS17_865 1.6e-89 335.5 Sphingomonadales efp GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02356 ko00000,ko03012 Bacteria 1MW2J@1224,2K0HQ@204457,2TUWE@28211,COG0231@1,COG0231@2 NA|NA|NA J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase HIMHAPGP_00060 1331060.RLDS_10040 3.2e-104 384.8 Sphingomonadales suhB 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUQT@1224,2K0TX@204457,2TR06@28211,COG0483@1,COG0483@2 NA|NA|NA G Inositol monophosphatase HIMHAPGP_00061 1234595.C725_0195 4.2e-44 184.1 unclassified Alphaproteobacteria nuoA GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044464,GO:0050136,GO:0055114,GO:0071944,GO:0098796,GO:1902494 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 1RGUT@1224,2U72Q@28211,4BQBD@82117,COG0838@1,COG0838@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient HIMHAPGP_00062 1331060.RLDS_26250 4.4e-131 474.6 Sphingomonadales ffh GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006605,GO:0006612,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0030312,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0040007,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046907,GO:0048500,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0071944,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1990904 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 Bacteria 1MVIA@1224,2K1DQ@204457,2TQSW@28211,COG0541@1,COG0541@2 NA|NA|NA U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components HIMHAPGP_00063 317655.Sala_2727 1.4e-40 172.6 Sphingomonadales rpsP GO:0000028,GO:0000217,GO:0000400,GO:0003674,GO:0003676,GO:0003677,GO:0003735,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006259,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016787,GO:0016788,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02959 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011,ko03029 Bacteria 1MZCT@1224,2K4I6@204457,2U94X@28211,COG0228@1,COG0228@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bS16 family HIMHAPGP_00064 1502850.FG91_01452 2.8e-45 188.3 Sphingomonadales rimM GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 ko:K02860 ko00000,ko03009 Bacteria 1MWQR@1224,2K4H2@204457,2U9UT@28211,COG0806@1,COG0806@2 NA|NA|NA J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes HIMHAPGP_00065 1088721.NSU_2881 6.9e-95 353.6 Sphingomonadales trmD GO:0000287,GO:0001510,GO:0002939,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050518,GO:0052906,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228,4.6.1.12 ko:K00554,ko:K01770 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R00597,R05637 RC00002,RC00003,RC00334,RC01440 ko00000,ko00001,ko00002,ko01000,ko03016 Bacteria 1MUN1@1224,2JZVZ@204457,2TSIZ@28211,COG0336@1,COG0336@2 NA|NA|NA J Belongs to the RNA methyltransferase TrmD family HIMHAPGP_00066 1081640.AGFU01000009_gene1385 6.9e-52 209.9 Sphingomonadales rplS GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02884 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1RH3A@1224,2K4GC@204457,2U9DF@28211,COG0335@1,COG0335@2 NA|NA|NA J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site HIMHAPGP_00068 1123240.ATVO01000003_gene275 1.1e-73 283.1 Sphingomonadales tolQ ko:K03562 ko01120,map01120 ko00000,ko02000 1.A.30.2.2 Bacteria 1NCWW@1224,2K039@204457,2TQXQ@28211,COG0811@1,COG0811@2 NA|NA|NA U MotA TolQ ExbB proton channel HIMHAPGP_00069 1123240.ATVO01000003_gene276 1e-24 119.8 Sphingomonadales tolR ko:K03560 ko00000,ko02000 1.A.30.2.2 Bacteria 1MZ6M@1224,2K53V@204457,2UA46@28211,COG0848@1,COG0848@2 NA|NA|NA U Biopolymer transport protein HIMHAPGP_00070 1248916.ANFY01000017_gene1389 1.7e-39 169.9 Sphingomonadales tolA Bacteria 1N5K2@1224,2JZY7@204457,2UB74@28211,COG5373@1,COG5373@2 NA|NA|NA S membrane HIMHAPGP_00071 1123240.ATVO01000003_gene279 1.7e-81 310.1 Sphingomonadales tolB GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0009719,GO:0009987,GO:0010033,GO:0010243,GO:0015031,GO:0015833,GO:0015893,GO:0017038,GO:0019534,GO:0019904,GO:0022857,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0032991,GO:0033036,GO:0042221,GO:0042493,GO:0042597,GO:0042886,GO:0042891,GO:0043213,GO:0044464,GO:0044877,GO:0045184,GO:0046677,GO:0046678,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0070887,GO:0071236,GO:0071237,GO:0071310,GO:0071417,GO:0071495,GO:0071702,GO:0071705,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1901998 ko:K03641 ko00000,ko02000 2.C.1.2 Bacteria 1MV09@1224,2K1NT@204457,2TR03@28211,COG0823@1,COG0823@2 NA|NA|NA U Involved in the TonB-independent uptake of proteins HIMHAPGP_00072 279238.Saro_0388 9.3e-42 176.8 Sphingomonadales pal ko:K03640 ko00000,ko02000 2.C.1.2 Bacteria 1MZTV@1224,2K49Y@204457,2U758@28211,COG2885@1,COG2885@2 NA|NA|NA M Belongs to the ompA family HIMHAPGP_00074 1123240.ATVO01000003_gene127 1e-166 593.6 Sphingomonadales glyS GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.14 ko:K01879,ko:K14164 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iAPECO1_1312.APECO1_2891,iE2348C_1286.E2348C_3810,iECABU_c1320.ECABU_c40010,iECED1_1282.ECED1_4242,iECH74115_1262.ECH74115_4934,iECNA114_1301.ECNA114_3710,iECOK1_1307.ECOK1_4005,iECP_1309.ECP_3661,iECS88_1305.ECS88_3976,iECSF_1327.ECSF_3393,iECSP_1301.ECSP_4554,iECs_1301.ECs4442,iG2583_1286.G2583_4300,iJN678.glyS,iUMN146_1321.UM146_17960,iUTI89_1310.UTI89_C4099,ic_1306.c4378 Bacteria 1MV2F@1224,2K16M@204457,2TQKJ@28211,COG0751@1,COG0751@2 NA|NA|NA J Glycyl-tRNA synthetase beta subunit HIMHAPGP_00075 1248916.ANFY01000017_gene1551 0.0 1234.9 Sphingomonadales ppdK 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 Bacteria 1MU0R@1224,2K0KY@204457,2TR3C@28211,COG0574@1,COG0574@2,COG1080@1,COG1080@2 NA|NA|NA G Belongs to the PEP-utilizing enzyme family HIMHAPGP_00076 543728.Vapar_0119 1.7e-112 412.9 Comamonadaceae 2.8.3.16 ko:K07749 ko00000,ko01000 Bacteria 1MU2K@1224,2VHFW@28216,4AAG0@80864,COG1804@1,COG1804@2 NA|NA|NA C PFAM L-carnitine dehydratase bile acid-inducible protein F HIMHAPGP_00077 629773.AORY01000004_gene355 2.4e-45 189.5 Sphingomonadales pldB GO:0003674,GO:0003824,GO:0004620,GO:0004622,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0008150,GO:0008152,GO:0016020,GO:0016298,GO:0016740,GO:0016746,GO:0016747,GO:0016787,GO:0016788,GO:0044238,GO:0044464,GO:0052689,GO:0071704,GO:0071944 3.1.1.5 ko:K01048 ko00564,map00564 ko00000,ko00001,ko01000 iETEC_1333.ETEC_4102,iEcHS_1320.EcHS_A4049 Bacteria 1MWDA@1224,2K0NG@204457,2TSZ4@28211,COG2267@1,COG2267@2 NA|NA|NA I Lysophospholipase HIMHAPGP_00078 1234595.C725_1134 7.1e-105 387.5 Alphaproteobacteria 1.4.99.6 ko:K19746 ko00472,ko01100,map00472,map01100 R11018 RC00006 ko00000,ko00001,ko01000 Bacteria 1MY0G@1224,2TRM2@28211,COG0665@1,COG0665@2 NA|NA|NA E COG0665 Glycine D-amino acid oxidases (deaminating) HIMHAPGP_00079 1123240.ATVO01000005_gene1897 8.1e-49 200.7 Sphingomonadales dsbG Bacteria 1RFF4@1224,2KCZI@204457,2U5BN@28211,COG1651@1,COG1651@2 NA|NA|NA O Thioredoxin HIMHAPGP_00083 1248916.ANFY01000003_gene601 7.2e-144 517.3 Sphingomonadales lysS 6.1.1.6 ko:K04566 ko00970,map00970 M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 1MV32@1224,2K1S0@204457,2TQYH@28211,COG1384@1,COG1384@2 NA|NA|NA J Belongs to the class-I aminoacyl-tRNA synthetase family HIMHAPGP_00084 1123240.ATVO01000009_gene788 2.8e-196 691.8 Sphingomonadales Bacteria 1MUBX@1224,2K0GU@204457,2TSUQ@28211,COG4805@1,COG4805@2 NA|NA|NA O protein conserved in bacteria HIMHAPGP_00085 1120705.FG95_03727 7.4e-130 470.7 Sphingomonadales Bacteria 1MVAF@1224,2K0Q2@204457,2TTYC@28211,COG1228@1,COG1228@2 NA|NA|NA Q COG1228 Imidazolonepropionase and related amidohydrolases HIMHAPGP_00086 1144307.PMI04_01776 3.6e-32 144.1 Sphingomonadales rplU GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02888 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1MZEW@1224,2K5A0@204457,2UBT3@28211,COG0261@1,COG0261@2 NA|NA|NA J This protein binds to 23S rRNA in the presence of protein L20 HIMHAPGP_00087 1174684.EBMC1_03585 6.5e-33 146.4 Sphingomonadales rpmA GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904 ko:K02899 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1MZGH@1224,2K60H@204457,2UBUX@28211,COG0211@1,COG0211@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL27 family HIMHAPGP_00090 1185876.BN8_06577 2.3e-08 66.2 Cytophagia Bacteria 47K98@768503,4NJW2@976,COG3291@1,COG3291@2 NA|NA|NA S C-terminal domain of CHU protein family HIMHAPGP_00091 1114964.L485_07730 4.7e-58 231.1 Sphingomonadales ribE GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.9,3.5.4.25,4.1.99.12 ko:K00793,ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00066,R00425,R07281 RC00293,RC00958,RC00960,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS08950 Bacteria 1MUMB@1224,2K0MU@204457,2U3RS@28211,COG0307@1,COG0307@2 NA|NA|NA H Riboflavin synthase HIMHAPGP_00092 1030157.AFMP01000016_gene2467 4.3e-82 311.6 Sphingomonadales ribD 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUWT@1224,2K10R@204457,2TR70@28211,COG0117@1,COG0117@2,COG1985@1,COG1985@2 NA|NA|NA H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate HIMHAPGP_00094 1123269.NX02_26815 6.4e-143 513.8 Sphingomonadales dnaN 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 1MVD9@1224,2K052@204457,2TSRZ@28211,COG0592@1,COG0592@2 NA|NA|NA L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria HIMHAPGP_00096 1112212.JH584235_gene2580 5.8e-113 414.1 Sphingomonadales Bacteria 1NR7X@1224,2K2GA@204457,2TT68@28211,COG3000@1,COG3000@2 NA|NA|NA I sterol desaturase HIMHAPGP_00097 745310.G432_15445 5.2e-92 344.7 Sphingomonadales pla GO:0003674,GO:0003824,GO:0006629,GO:0008150,GO:0008152,GO:0009056,GO:0016042,GO:0016298,GO:0016787,GO:0016788,GO:0044238,GO:0071704,GO:1901575 Bacteria 1MVDA@1224,2K1MR@204457,2TUDQ@28211,COG2267@1,COG2267@2 NA|NA|NA I Protein of unknown function (DUF3089) HIMHAPGP_00098 1123267.JONN01000002_gene120 2.5e-41 175.3 Sphingomonadales yqgF GO:0000966,GO:0000967,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0140097,GO:1901360 ko:K07447 ko00000,ko01000 Bacteria 1RDHZ@1224,2K4GA@204457,2U98Y@28211,COG0816@1,COG0816@2 NA|NA|NA L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA HIMHAPGP_00100 685778.AORL01000021_gene857 1.5e-190 672.5 Sphingomonadales gatA 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 Bacteria 1MUVQ@1224,2K0UD@204457,2TRFY@28211,COG0154@1,COG0154@2 NA|NA|NA J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) HIMHAPGP_00101 1248916.ANFY01000007_gene2288 1e-23 115.9 Sphingomonadales gatC 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 iAF987.Gmet_0076 Bacteria 1MZQP@1224,2K5XM@204457,2UBSZ@28211,COG0721@1,COG0721@2 NA|NA|NA J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) HIMHAPGP_00102 318167.Sfri_1083 5.2e-52 211.1 Gammaproteobacteria frnE Bacteria 1NXUB@1224,1S2Z2@1236,COG2761@1,COG2761@2 NA|NA|NA Q dithiol-disulfide isomerase involved in polyketide biosynthesis HIMHAPGP_00103 1248916.ANFY01000012_gene1930 2.2e-15 87.4 Sphingomonadales radC ko:K03630 ko00000 Bacteria 1MXZ5@1224,2K0WQ@204457,2TQXM@28211,COG2003@1,COG2003@2 NA|NA|NA L Belongs to the UPF0758 family HIMHAPGP_00104 1121022.ABENE_03710 1.3e-119 436.4 Caulobacterales 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 R01776 RC00004,RC00041 ko00000,ko00001,ko01000 Bacteria 1MVJV@1224,2KFF5@204458,2TTTV@28211,COG2021@1,COG2021@2 NA|NA|NA E Belongs to the AB hydrolase superfamily. MetX family HIMHAPGP_00105 1123240.ATVO01000004_gene1182 1.1e-104 387.1 Sphingomonadales MA20_25070 ko:K06902 ko04138,map04138 ko00000,ko00001,ko02000,ko04131 2.A.1.24,9.A.15.1 Bacteria 1MWXB@1224,2K4XI@204457,2TSCV@28211,COG2270@1,COG2270@2 NA|NA|NA S Vacuole effluxer Atg22 like HIMHAPGP_00106 1112212.JH584235_gene2823 1.6e-173 615.9 Sphingomonadales pyk GO:0003674,GO:0003824,GO:0004743,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 Bacteria 1MU21@1224,2K07D@204457,2TRFV@28211,COG0469@1,COG0469@2 NA|NA|NA G Belongs to the pyruvate kinase family HIMHAPGP_00107 1449049.JONW01000006_gene3229 1.8e-26 125.6 Alphaproteobacteria MA20_03865 ko:K09948 ko00000 Bacteria 1MZ3I@1224,2UC11@28211,COG3492@1,COG3492@2 NA|NA|NA S Protein conserved in bacteria HIMHAPGP_00108 59538.XP_005973549.1 2.7e-130 471.9 Opisthokonta Opisthokonta 38EN0@33154,COG1902@1,KOG0134@2759 NA|NA|NA C Nadh flavin oxidoreductase nadh oxidase HIMHAPGP_00110 1088721.NSU_0275 2.5e-34 152.1 Alphaproteobacteria intD Bacteria 1R7GV@1224,2TT06@28211,COG0582@1,COG0582@2 NA|NA|NA L Belongs to the 'phage' integrase family HIMHAPGP_00111 1030157.AFMP01000040_gene1588 3.1e-84 318.2 Sphingomonadales gst2 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 Bacteria 1PENB@1224,2K49C@204457,2TRVC@28211,COG0625@1,COG0625@2 NA|NA|NA O Glutathione S-transferase, N-terminal domain HIMHAPGP_00112 1030157.AFMP01000040_gene1589 1.7e-52 212.2 Sphingomonadales Bacteria 1N76T@1224,2C7KN@1,2KEX1@204457,2U033@28211,32RJD@2 NA|NA|NA HIMHAPGP_00113 392499.Swit_0269 1.5e-256 891.7 Sphingomonadales katA GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070887,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1990748 1.11.1.6 ko:K03781 ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014 M00532 R00009,R00602,R02670 RC00034,RC00767,RC02141,RC02755 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUXZ@1224,2K1IE@204457,2TSG9@28211,COG0753@1,COG0753@2 NA|NA|NA P Serves to protect cells from the toxic effects of hydrogen peroxide HIMHAPGP_00114 745310.G432_06420 6.8e-227 793.9 Sphingomonadales ko:K02014 ko00000,ko02000 1.B.14 Bacteria 1QTXJ@1224,2K17K@204457,2UNSU@28211,COG4773@1,COG4773@2 NA|NA|NA P receptor HIMHAPGP_00116 979556.MTES_3333 5.5e-66 256.9 Microbacteriaceae clpP GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 ko00000,ko00001,ko01000,ko01002 Bacteria 2GKNK@201174,4FKH7@85023,COG0740@1,COG0740@2 NA|NA|NA OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins HIMHAPGP_00117 1219045.BV98_003587 2.3e-85 321.6 Sphingomonadales ahcY GO:0000096,GO:0000097,GO:0000098,GO:0000166,GO:0001666,GO:0002376,GO:0002437,GO:0002439,GO:0002544,GO:0003674,GO:0003824,GO:0004013,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006152,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0006950,GO:0006952,GO:0006954,GO:0006955,GO:0007584,GO:0007610,GO:0007622,GO:0007623,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009087,GO:0009116,GO:0009119,GO:0009164,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016053,GO:0016054,GO:0016787,GO:0016801,GO:0016802,GO:0017076,GO:0017144,GO:0019439,GO:0019510,GO:0019752,GO:0019899,GO:0022610,GO:0030260,GO:0030312,GO:0030554,GO:0031667,GO:0033353,GO:0034641,GO:0034655,GO:0034656,GO:0035375,GO:0035635,GO:0036094,GO:0036293,GO:0040007,GO:0042219,GO:0042221,GO:0042278,GO:0042454,GO:0042745,GO:0042802,GO:0042995,GO:0043005,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0044650,GO:0046085,GO:0046128,GO:0046130,GO:0046394,GO:0046395,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0046700,GO:0048037,GO:0048511,GO:0048512,GO:0050662,GO:0050667,GO:0050896,GO:0051186,GO:0051187,GO:0051287,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0055086,GO:0070403,GO:0070482,GO:0071268,GO:0071704,GO:0071944,GO:0072521,GO:0072523,GO:0097159,GO:0097458,GO:0098604,GO:0120025,GO:1901135,GO:1901136,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1901657,GO:1901658 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 Bacteria 1MUQ2@1224,2K0R8@204457,2TSJY@28211,COG0499@1,COG0499@2 NA|NA|NA H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine HIMHAPGP_00118 1248916.ANFY01000003_gene833 2.4e-40 171.8 Sphingomonadales yjeE 2.7.1.221 ko:K06925,ko:K07102 ko00520,ko01100,map00520,map01100 R08968,R11024 RC00002,RC00078 ko00000,ko00001,ko01000,ko03016 Bacteria 1RGYU@1224,2K5A7@204457,2UBQ9@28211,COG0802@1,COG0802@2 NA|NA|NA S ATPase or kinase HIMHAPGP_00119 1030157.AFMP01000009_gene3672 3.5e-106 391.7 Sphingomonadales MA20_24090 2.7.1.221 ko:K07102 ko00520,ko01100,map00520,map01100 R08968,R11024 RC00002,RC00078 ko00000,ko00001,ko01000 Bacteria 1MXCH@1224,2K04R@204457,2TSJD@28211,COG3178@1,COG3178@2 NA|NA|NA S Phosphotransferase HIMHAPGP_00120 745310.G432_04515 1.8e-85 322.4 Sphingomonadales rmlA GO:0000166,GO:0000270,GO:0000287,GO:0001882,GO:0001884,GO:0002134,GO:0003674,GO:0003824,GO:0005488,GO:0006022,GO:0006040,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0019103,GO:0019752,GO:0030203,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044281,GO:0046872,GO:0070569,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564 2.7.7.13,2.7.7.24,2.7.7.99 ko:K00966,ko:K00973,ko:K00992 ko00051,ko00520,ko00521,ko00523,ko00525,ko01100,ko01110,ko01130,map00051,map00520,map00521,map00523,map00525,map01100,map01110,map01130 M00114,M00361,M00362,M00793 R00885,R02328,R11025 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 1R9ZD@1224,2K1HH@204457,2TU2V@28211,COG1208@1,COG1208@2 NA|NA|NA JM Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon) HIMHAPGP_00121 1123269.NX02_08515 4.8e-182 645.2 Sphingomonadales addB 3.1.11.5,3.6.4.12 ko:K01144,ko:K02259,ko:K16899 ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714 M00154 R07412 RC00769 ko00000,ko00001,ko00002,ko01000,ko03029,ko03400 3.D.4.4 Bacteria 1MY2G@1224,2K06P@204457,2TS74@28211,COG2887@1,COG2887@2,COG3893@1,COG3893@2 NA|NA|NA L helicase HIMHAPGP_00122 1234595.C725_2346 5e-218 765.0 unclassified Alphaproteobacteria addA 3.6.4.12 ko:K16898 ko00000,ko01000,ko03400 Bacteria 1MUTF@1224,2TQJZ@28211,4BP6D@82117,COG1074@1,COG1074@2 NA|NA|NA L PD-(D/E)XK nuclease superfamily HIMHAPGP_00123 420324.KI912020_gene7445 1.5e-36 158.7 Methylobacteriaceae trxA GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 ko:K03671 ko04621,ko05418,map04621,map05418 ko00000,ko00001,ko03110 iECW_1372.ECW_m4079,iECs_1301.ECs4714,iEKO11_1354.EKO11_4576,iG2583_1286.G2583_4574,iSBO_1134.SBO_3791,iSDY_1059.SDY_3968,iSF_1195.SF3854,iSSON_1240.SSON_3952,iS_1188.S3905,iWFL_1372.ECW_m4079,iZ_1308.Z5291 Bacteria 1JVD0@119045,1MZBB@1224,2UCCR@28211,COG3118@1,COG3118@2 NA|NA|NA O Belongs to the thioredoxin family HIMHAPGP_00125 1248916.ANFY01000005_gene2768 0.0 1147.1 Sphingomonadales lon GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004175,GO:0004176,GO:0004252,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009408,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0017171,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051603,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.4.21.53 ko:K01338 ko04112,map04112 ko00000,ko00001,ko01000,ko01002 Bacteria 1MUV2@1224,2K15B@204457,2TR4E@28211,COG0466@1,COG0466@2 NA|NA|NA O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner HIMHAPGP_00126 1123267.JONN01000002_gene273 9.3e-165 586.6 Sphingomonadales Bacteria 1MU46@1224,2K0IY@204457,2TRAP@28211,COG0477@1,COG0477@2 NA|NA|NA EGP Major Facilitator HIMHAPGP_00127 1030157.AFMP01000044_gene1927 7.8e-96 356.7 Sphingomonadales tal 2.2.1.2 ko:K00616 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01827 RC00439,RC00604 ko00000,ko00001,ko00002,ko01000 Bacteria 1MWQ8@1224,2K0F2@204457,2TQJB@28211,COG0176@1,COG0176@2 NA|NA|NA G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway HIMHAPGP_00128 1550073.JROH01000023_gene831 2.7e-86 325.5 Sphingomonadales xerC ko:K03733 ko00000,ko03036 Bacteria 1QU6A@1224,2K1R3@204457,2TS7W@28211,COG4974@1,COG4974@2 NA|NA|NA L Belongs to the 'phage' integrase family HIMHAPGP_00129 1248916.ANFY01000005_gene2696 1.2e-121 443.4 Sphingomonadales nylB Bacteria 1P3SQ@1224,2K2VN@204457,2U0E0@28211,COG1680@1,COG1680@2 NA|NA|NA V Beta-lactamase HIMHAPGP_00130 1349767.GJA_886 2.7e-11 75.9 Betaproteobacteria Bacteria 1P2QI@1224,2EJQF@1,2W42V@28216,33DF9@2 NA|NA|NA HIMHAPGP_00131 685778.AORL01000010_gene2597 9.8e-227 792.7 Sphingomonadales fumA 4.2.1.2 ko:K01676,ko:K01677,ko:K01678 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUV9@1224,2K26A@204457,2TT46@28211,COG1838@1,COG1838@2,COG1951@1,COG1951@2 NA|NA|NA C Catalyzes the reversible hydration of fumarate to (S)- malate HIMHAPGP_00132 1123267.JONN01000001_gene1960 1.5e-301 1041.6 Sphingomonadales nrdA 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 Bacteria 1MUJ8@1224,2K0F8@204457,2TS19@28211,COG0209@1,COG0209@2 NA|NA|NA F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides HIMHAPGP_00133 1219045.BV98_002001 1.2e-178 632.5 Sphingomonadales nrdB 1.17.4.1 ko:K00526,ko:K03676 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03110,ko03400 Bacteria 1MWUS@1224,2K1H7@204457,2TS3X@28211,COG0208@1,COG0208@2 NA|NA|NA F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides HIMHAPGP_00134 172088.AUGA01000037_gene3733 1.9e-62 245.7 Bradyrhizobiaceae Bacteria 1MUPF@1224,2TQMB@28211,3JVFH@41294,COG0179@1,COG0179@2 NA|NA|NA Q Fumarylacetoacetate (FAA) hydrolase family HIMHAPGP_00135 685778.AORL01000019_gene1770 1e-54 219.9 Sphingomonadales MA20_46305 Bacteria 1RASG@1224,2K1IC@204457,2U590@28211,COG5400@1,COG5400@2 NA|NA|NA S conserved protein UCP033924 precursor HIMHAPGP_00136 1248916.ANFY01000009_gene250 3.5e-190 671.8 Sphingomonadales lptD ko:K04744 ko00000,ko02000 1.B.42.1 Bacteria 1MUJC@1224,2K1GQ@204457,2TR3B@28211,COG1452@1,COG1452@2 NA|NA|NA M Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane HIMHAPGP_00137 1248916.ANFY01000009_gene251 1.2e-143 516.5 Sphingomonadales surA 5.2.1.8 ko:K02597,ko:K03769,ko:K03771 ko00000,ko01000,ko03110 Bacteria 1MVB3@1224,2K0UR@204457,2TSJ3@28211,COG0760@1,COG0760@2 NA|NA|NA O peptidylprolyl isomerase HIMHAPGP_00139 745310.G432_00625 5.3e-50 204.9 Sphingomonadales holB GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 1MY1W@1224,2JZZA@204457,2TV3E@28211,COG0470@1,COG0470@2 NA|NA|NA L DNA polymerase HIMHAPGP_00140 1248916.ANFY01000009_gene306 2.3e-297 1027.7 Sphingomonadales thiC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016020,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0040007,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 iECABU_c1320.ECABU_c45100,iYO844.BSU08790 Bacteria 1MUVV@1224,2JZYN@204457,2TS0S@28211,COG0422@1,COG0422@2 NA|NA|NA H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction HIMHAPGP_00141 1192759.AKIB01000012_gene2745 2.1e-97 363.2 Sphingomonadales Bacteria 1NMS3@1224,2K04U@204457,2U1ZY@28211,COG1808@1,COG1808@2,COG2885@1,COG2885@2 NA|NA|NA PT Domain of unknown function (DUF389) HIMHAPGP_00142 1123240.ATVO01000007_gene2184 9.2e-80 303.1 Sphingomonadales clpX GO:0000166,GO:0000502,GO:0002020,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009376,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019899,GO:0019904,GO:0030163,GO:0030164,GO:0030312,GO:0030554,GO:0031333,GO:0031597,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0043335,GO:0044087,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0051704,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0097718,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 ko:K03544 ko04112,map04112 ko00000,ko00001,ko03110 Bacteria 1MVQK@1224,2JZWY@204457,2TS3R@28211,COG1219@1,COG1219@2 NA|NA|NA O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP HIMHAPGP_00145 1007104.SUS17_3999 1.4e-12 78.2 Sphingomonadales pntAB GO:0008150,GO:0008152,GO:0055114 1.6.1.1,1.6.1.2 ko:K00322,ko:K00324 ko00760,ko01100,map00760,map01100 R00112 RC00001 ko00000,ko00001,ko01000 Bacteria 1MZ3E@1224,2K5AR@204457,2UBXS@28211,COG3288@1,COG3288@2 NA|NA|NA C nad(P) transhydrogenase subunit alpha HIMHAPGP_00146 1030157.AFMP01000036_gene2681 5.6e-126 457.6 Sphingomonadales pntAA GO:0000166,GO:0003674,GO:0003824,GO:0003957,GO:0005215,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0008746,GO:0008750,GO:0009117,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0016491,GO:0016651,GO:0016652,GO:0019362,GO:0019637,GO:0022857,GO:0022890,GO:0034220,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046496,GO:0046983,GO:0048037,GO:0050662,GO:0051179,GO:0051186,GO:0051234,GO:0051287,GO:0055085,GO:0055086,GO:0055114,GO:0070403,GO:0070404,GO:0071704,GO:0072524,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1902600 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 R00112 RC00001 ko00000,ko00001,ko01000 Bacteria 1MVXU@1224,2K062@204457,2TSZN@28211,COG3288@1,COG3288@2 NA|NA|NA C NAD(P) transhydrogenase subunit alpha HIMHAPGP_00148 1101190.ARWB01000001_gene1910 5.1e-142 511.1 Methylocystaceae Bacteria 1MW1J@1224,2TSHG@28211,36ZRT@31993,COG0661@1,COG0661@2 NA|NA|NA S ABC1 family HIMHAPGP_00149 1123240.ATVO01000003_gene111 4.7e-82 311.2 Sphingomonadales petC ko:K00410,ko:K00412,ko:K00413 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 ko00000,ko00001,ko00002,ko03029 iIT341.HP1538 Bacteria 1QFU2@1224,2K07X@204457,2TUHX@28211,COG2857@1,COG2857@2 NA|NA|NA C Cytochrome c1 HIMHAPGP_00150 13690.CP98_01061 1.6e-198 698.7 Sphingomonadales petB ko:K00410,ko:K00412,ko:K02635,ko:K02637 ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152,M00162 ko00000,ko00001,ko00002,ko00194,ko03029 Bacteria 1MV97@1224,2K0CE@204457,2TSZ3@28211,COG1290@1,COG1290@2 NA|NA|NA C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis HIMHAPGP_00151 1502850.FG91_00214 8.3e-70 270.0 Sphingomonadales petA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.10.2.2 ko:K00411 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 ko00000,ko00001,ko00002,ko01000 Bacteria 1RAA2@1224,2K1YX@204457,2TTT2@28211,COG0723@1,COG0723@2 NA|NA|NA C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis HIMHAPGP_00152 398580.Dshi_1767 1.5e-42 179.5 Alphaproteobacteria yvdD GO:0003674,GO:0003824,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009308,GO:0009690,GO:0009691,GO:0009987,GO:0010817,GO:0016787,GO:0016798,GO:0016799,GO:0034754,GO:0042445,GO:0042446,GO:0044237,GO:0044249,GO:0046483,GO:0065007,GO:0065008,GO:0071704,GO:1901564 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 Bacteria 1RD59@1224,2U5DP@28211,COG1611@1,COG1611@2 NA|NA|NA K Belongs to the LOG family HIMHAPGP_00154 1248916.ANFY01000020_gene1644 3.2e-91 341.7 Sphingomonadales trpA 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 Bacteria 1MXJV@1224,2K0XH@204457,2TQN2@28211,COG0159@1,COG0159@2 NA|NA|NA E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate HIMHAPGP_00155 1248916.ANFY01000020_gene1645 9.7e-107 393.3 Sphingomonadales accD GO:0001676,GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003729,GO:0003824,GO:0003989,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006417,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0009058,GO:0009317,GO:0009329,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0017148,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032787,GO:0032991,GO:0034248,GO:0034249,GO:0042759,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:0097159,GO:1901363,GO:1901576,GO:1902494,GO:1990234,GO:2000112,GO:2000113 2.1.3.15,6.4.1.2 ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 iJN678.accD,iPC815.YPO2768,iUTI89_1310.UTI89_C2601 Bacteria 1MW8G@1224,2K159@204457,2TRSH@28211,COG0777@1,COG0777@2 NA|NA|NA I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA HIMHAPGP_00156 1248916.ANFY01000020_gene1646 2.3e-118 432.6 Sphingomonadales folC GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2475,iJN746.PP_1997,iSDY_1059.SDY_2514 Bacteria 1MVCH@1224,2K1S3@204457,2TR64@28211,COG0285@1,COG0285@2 NA|NA|NA H Belongs to the folylpolyglutamate synthase family HIMHAPGP_00157 1346791.M529_13550 9.7e-69 266.9 Sphingomonadales scpA ko:K05896 ko00000,ko03036 Bacteria 1MVCN@1224,2K15W@204457,2TS1V@28211,COG1354@1,COG1354@2 NA|NA|NA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves HIMHAPGP_00158 392499.Swit_3933 7.3e-59 233.8 Sphingomonadales nagZ 3.2.1.21,3.2.1.52 ko:K01207,ko:K05349 ko00460,ko00500,ko00520,ko00531,ko00940,ko01100,ko01110,ko01501,map00460,map00500,map00520,map00531,map00940,map01100,map01110,map01501 M00628 R00022,R00026,R02558,R02887,R02985,R03527,R04949,R04998,R05963,R07809,R07810,R10035,R10039,R10040,R10831 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko00002,ko01000 GH3 Bacteria 1MVAJ@1224,2JZUV@204457,2TRJK@28211,COG1472@1,COG1472@2 NA|NA|NA G beta-N-acetylhexosaminidase HIMHAPGP_00159 452662.SJA_C1-22860 2.5e-222 778.1 Sphingomonadales dxs GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008614,GO:0008615,GO:0008654,GO:0008661,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009240,GO:0009987,GO:0016740,GO:0016744,GO:0017144,GO:0018130,GO:0019288,GO:0019438,GO:0019637,GO:0019682,GO:0019752,GO:0019842,GO:0030145,GO:0030975,GO:0030976,GO:0032787,GO:0034641,GO:0036094,GO:0040007,GO:0042180,GO:0042181,GO:0042364,GO:0042723,GO:0042724,GO:0042816,GO:0042819,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:1901135,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663,GO:1901681 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 iEcSMS35_1347.EcSMS35_0456,iJN746.PP_0527 Bacteria 1MUSJ@1224,2K0XY@204457,2TRDD@28211,COG1154@1,COG1154@2 NA|NA|NA H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) HIMHAPGP_00160 1081640.AGFU01000025_gene2490 8.8e-90 336.7 Sphingomonadales tlyA GO:0000154,GO:0001510,GO:0001897,GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019835,GO:0019836,GO:0022613,GO:0031167,GO:0031640,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035821,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044003,GO:0044004,GO:0044085,GO:0044179,GO:0044237,GO:0044238,GO:0044260,GO:0044364,GO:0044403,GO:0044419,GO:0044764,GO:0046483,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.226,2.1.1.227 ko:K06442 ko00000,ko01000,ko03009 Bacteria 1MWP5@1224,2K0J2@204457,2TRW9@28211,COG1189@1,COG1189@2 NA|NA|NA J Hemolysin HIMHAPGP_00161 1123240.ATVO01000006_gene1343 1.1e-24 120.2 Sphingomonadales MA20_36110 Bacteria 1N3RI@1224,2K476@204457,2UDTZ@28211,COG5490@1,COG5490@2 NA|NA|NA S Phasin protein HIMHAPGP_00162 627192.SLG_37770 3.5e-186 657.9 Sphingomonadales algC GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 5.4.2.2,5.4.2.8 ko:K01835,ko:K01840,ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114,M00549 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUA5@1224,2K0Q1@204457,2TRIJ@28211,COG1109@1,COG1109@2 NA|NA|NA G phosphomannomutase HIMHAPGP_00163 392499.Swit_2790 5.1e-08 63.2 Alphaproteobacteria Bacteria 1PUS9@1224,2TT35@28211,COG2214@1,COG2214@2 NA|NA|NA O PFAM heat shock protein DnaJ domain protein HIMHAPGP_00165 279238.Saro_1356 3.1e-25 120.9 Sphingomonadales MA20_30235 1.6.5.3 ko:K00329 ko00190,map00190 R11945 RC00061 ko00000,ko00001,ko01000 Bacteria 1MZK8@1224,2C7TH@1,2K5XZ@204457,2UC2R@28211,32RJS@2 NA|NA|NA S ETC complex I subunit HIMHAPGP_00166 1174684.EBMC1_15679 2.2e-125 455.7 Sphingomonadales yhfN GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0070011,GO:0071586,GO:0071704,GO:0080120,GO:0140096,GO:1901564 3.4.24.84 ko:K06013 ko00900,ko01130,map00900,map01130 R09845 RC00141 ko00000,ko00001,ko01000,ko01002,ko04147 Bacteria 1MUXT@1224,2K2GU@204457,2TVI9@28211,COG0501@1,COG0501@2 NA|NA|NA O CAAX prenyl protease N-terminal, five membrane helices HIMHAPGP_00167 1123269.NX02_27840 8.6e-225 786.9 Sphingomonadales hrpB 3.6.4.13 ko:K03579 ko00000,ko01000 Bacteria 1MUEQ@1224,2K0GM@204457,2TRMJ@28211,COG1643@1,COG1643@2 NA|NA|NA L ATP-dependent helicase HIMHAPGP_00168 1550073.JROH01000001_gene639 2.6e-115 422.2 Sphingomonadales ispB GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663 2.5.1.30,2.5.1.90 ko:K00805,ko:K02523 ko00900,ko01110,map00900,map01110 R09247,R09248 RC00279 ko00000,ko00001,ko01000,ko01006 iYL1228.KPN_03597,ic_1306.c3945 Bacteria 1MUK6@1224,2JZY9@204457,2TSDZ@28211,COG0142@1,COG0142@2 NA|NA|NA H Belongs to the FPP GGPP synthase family HIMHAPGP_00169 685778.AORL01000006_gene3443 2.7e-59 234.6 Sphingomonadales sucD 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUGA@1224,2K1F5@204457,2TQKB@28211,COG0074@1,COG0074@2 NA|NA|NA C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit HIMHAPGP_00170 1248916.ANFY01000017_gene1362 0.0 1294.6 Sphingomonadales sucA GO:0000287,GO:0003674,GO:0003824,GO:0004591,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016624,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0019842,GO:0022900,GO:0030312,GO:0030976,GO:0032991,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0048037,GO:0050439,GO:0050662,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234 1.2.4.2,4.1.1.71 ko:K00164,ko:K01616 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1248c,iSSON_1240.SSON_0677,iYL1228.KPN_00732 Bacteria 1MVBF@1224,2K1J3@204457,2TRBQ@28211,COG0567@1,COG0567@2 NA|NA|NA C E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate HIMHAPGP_00171 1248916.ANFY01000010_gene452 1.5e-105 389.0 Sphingomonadales typA GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840 ko:K06207 ko00000 Bacteria 1MV5Q@1224,2K169@204457,2TR63@28211,COG1217@1,COG1217@2 NA|NA|NA T GTP-binding protein TypA HIMHAPGP_00173 1123240.ATVO01000008_gene2439 1.1e-40 172.9 Sphingomonadales tadA GO:0002097,GO:0002100,GO:0003674,GO:0003824,GO:0004000,GO:0005488,GO:0006139,GO:0006382,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008251,GO:0008270,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016553,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0052717,GO:0071704,GO:0090304,GO:1901360 3.4.17.13,3.5.4.1,3.5.4.3,3.5.4.33,3.8.1.5 ko:K01297,ko:K01485,ko:K01487,ko:K01563,ko:K11991 ko00230,ko00240,ko00330,ko00361,ko00625,ko01100,ko01120,map00230,map00240,map00330,map00361,map00625,map01100,map01120 R00974,R01411,R01676,R02922,R05284,R05367,R05368,R05369,R05370,R07669,R07670,R10223 RC00074,RC00204,RC00477,RC00514,RC00809,RC01317,RC01340,RC01341,RC02013 ko00000,ko00001,ko01000,ko01002,ko01011,ko03016 Bacteria 1RGU0@1224,2K4E6@204457,2U77Q@28211,COG0590@1,COG0590@2 NA|NA|NA FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) HIMHAPGP_00174 1510531.JQJJ01000008_gene3614 1.5e-54 218.8 Bradyrhizobiaceae msrB 1.8.4.12 ko:K07305 ko00000,ko01000 Bacteria 1RGWC@1224,2U70T@28211,3JSXE@41294,COG0229@1,COG0229@2 NA|NA|NA O methionine sulfoxide reductase HIMHAPGP_00175 1007104.SUS17_207 1.7e-106 392.9 Sphingomonadales aroB GO:0000166,GO:0003674,GO:0003824,GO:0003856,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0051287,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.71,4.2.3.4 ko:K01735,ko:K13829 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412,R03083 RC00002,RC00078,RC00847 ko00000,ko00001,ko00002,ko01000 iAF1260.b3389,iBWG_1329.BWG_3080,iECDH10B_1368.ECDH10B_3564,iECDH1ME8569_1439.ECDH1ME8569_3268,iECNA114_1301.ECNA114_3486,iEcDH1_1363.EcDH1_0324,iIT341.HP0283,iJO1366.b3389,iJR904.b3389,iY75_1357.Y75_RS20275 Bacteria 1MUBK@1224,2K0HR@204457,2TRDA@28211,COG0337@1,COG0337@2 NA|NA|NA E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) HIMHAPGP_00176 1081640.AGFU01000009_gene1466 2.5e-53 215.3 Sphingomonadales aroK 2.7.1.71,4.2.3.4 ko:K00891,ko:K13829 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412,R03083 RC00002,RC00078,RC00847 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUFJ@1224,2K4PP@204457,2U76C@28211,COG0703@1,COG0703@2 NA|NA|NA F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate HIMHAPGP_00177 1248916.ANFY01000003_gene634 8.8e-73 281.6 Sphingomonadales Bacteria 1R42X@1224,2BWFC@1,2K0XT@204457,2U4BF@28211,33R2I@2 NA|NA|NA HIMHAPGP_00178 702113.PP1Y_Mpl2820 1.7e-108 399.8 Sphingomonadales nylA 3.5.1.4,6.3.5.6,6.3.5.7 ko:K01426,ko:K02433 ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120 R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000,ko03029 Bacteria 1MWWQ@1224,2K183@204457,2TSN9@28211,COG0154@1,COG0154@2 NA|NA|NA J Belongs to the amidase family HIMHAPGP_00179 46429.BV95_02363 4.4e-127 461.5 Sphingomonadales metC GO:0000096,GO:0000098,GO:0003674,GO:0003824,GO:0004121,GO:0005488,GO:0006082,GO:0006090,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009093,GO:0009987,GO:0016054,GO:0016829,GO:0016846,GO:0019448,GO:0019450,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0046395,GO:0046439,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 4.4.1.11,4.4.1.8 ko:K01760,ko:K01761,ko:K10764 ko00270,ko00450,ko00920,ko01100,ko01110,ko01230,map00270,map00450,map00920,map01100,map01110,map01230 M00017 R00654,R00782,R01286,R01288,R02408,R04770,R04941 RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848 ko00000,ko00001,ko00002,ko01000 iSbBS512_1146.SbBS512_E3435,iUTI89_1310.UTI89_C3428 Bacteria 1MU9E@1224,2K0WB@204457,2TS8Z@28211,COG0626@1,COG0626@2 NA|NA|NA E cystathionine beta-lyase HIMHAPGP_00180 1123240.ATVO01000003_gene354 1.5e-99 369.4 Sphingomonadales sseA 2.8.1.1,2.8.1.2,4.4.1.8 ko:K01011,ko:K01760 ko00270,ko00450,ko00920,ko01100,ko01110,ko01120,ko01230,ko04122,map00270,map00450,map00920,map01100,map01110,map01120,map01230,map04122 M00017 R00782,R01286,R01931,R02408,R03105,R03106,R04941 RC00056,RC00069,RC00214,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko00002,ko01000 Bacteria 1MW4B@1224,2K1GF@204457,2TR9R@28211,COG2897@1,COG2897@2 NA|NA|NA P Catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds HIMHAPGP_00183 745310.G432_09755 2.5e-121 441.8 Sphingomonadales Bacteria 1MW05@1224,2K0U5@204457,2TS7R@28211,COG2939@1,COG2939@2 NA|NA|NA E peptidase S10 serine carboxypeptidase HIMHAPGP_00184 883126.HMPREF9710_02508 1.2e-81 309.7 Betaproteobacteria Bacteria 1MXQR@1224,2VIQY@28216,COG1028@1,COG1028@2 NA|NA|NA IQ Dehydrogenase HIMHAPGP_00185 253839.SSNG_00412 7.5e-85 320.5 Actinobacteria echA5 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 Bacteria 2GJ63@201174,COG1024@1,COG1024@2 NA|NA|NA I Belongs to the enoyl-CoA hydratase isomerase family HIMHAPGP_00186 1122614.JHZF01000013_gene3519 1.8e-08 66.2 Bacteria hdeD GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009268,GO:0009628,GO:0016020,GO:0044464,GO:0050896,GO:0071944 ko:K21908 ko00000 9.B.36.1.1 Bacteria COG3247@1,COG3247@2 NA|NA|NA U response to pH HIMHAPGP_00187 1038859.AXAU01000001_gene3282 4.7e-32 144.4 Alphaproteobacteria Bacteria 1RC5W@1224,2U6VR@28211,COG4803@1,COG4803@2 NA|NA|NA S membrane HIMHAPGP_00188 1123269.NX02_13005 5.3e-206 724.5 Sphingomonadales dpp4 3.4.14.5 ko:K01278,ko:K01990 ko04974,map04974 M00254 ko00000,ko00001,ko00002,ko01000,ko01002,ko02000,ko04090,ko04147 3.A.1 Bacteria 1P6E1@1224,2K0U1@204457,2TRVE@28211,COG1506@1,COG1506@2 NA|NA|NA E peptidase S9 HIMHAPGP_00192 1267535.KB906767_gene460 2.5e-60 238.8 Bacteria mgtC ko:K07507 ko00000,ko02000 9.B.20 Bacteria COG1285@1,COG1285@2 NA|NA|NA E pathogenesis HIMHAPGP_00194 1550073.JROH01000026_gene1007 0.0 1218.4 Sphingomonadales Bacteria 1N6JG@1224,2K0T9@204457,2TSK9@28211,COG1629@1,COG4771@2 NA|NA|NA P Carboxypeptidase regulatory-like domain HIMHAPGP_00195 935565.JAEM01000051_gene4311 7.3e-35 154.8 Paracoccus Bacteria 1MXJJ@1224,2PUWK@265,2TTH6@28211,COG3391@1,COG3391@2,COG3544@1,COG3544@2 NA|NA|NA S Domain of unknown function (DUF305) HIMHAPGP_00197 158500.BV97_00405 2.8e-39 168.7 Sphingomonadales plsY 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 1RD4Z@1224,2K0BP@204457,2U7BZ@28211,COG0344@1,COG0344@2 NA|NA|NA I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP HIMHAPGP_00198 1231190.NA8A_12070 6.9e-47 193.4 Phyllobacteriaceae yrkC Bacteria 1RJ7D@1224,2UAG4@28211,43K3J@69277,COG0662@1,COG0662@2 NA|NA|NA G AraC-like ligand binding domain HIMHAPGP_00199 1123240.ATVO01000004_gene1148 8.1e-29 133.7 Sphingomonadales pssE Bacteria 1MZGV@1224,2K671@204457,2UBWE@28211,COG5017@1,COG5017@2 NA|NA|NA S Glycosyltransferase family 28 C-terminal domain HIMHAPGP_00200 1354722.JQLS01000004_gene4055 1.6e-42 179.1 Roseovarius cpsF Bacteria 1RJH9@1224,2UCZ1@28211,46REU@74030,COG0707@1,COG0707@2 NA|NA|NA M Oligosaccharide biosynthesis protein Alg14 like HIMHAPGP_00201 1123240.ATVO01000010_gene692 6.6e-173 613.6 Sphingomonadales gcdH GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 1.3.8.6 ko:K00252 ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130 M00032 R02487,R02488,R10074 RC00052,RC00156 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUK0@1224,2K030@204457,2TSAC@28211,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase HIMHAPGP_00202 450851.PHZ_c2276 7.8e-81 307.8 Caulobacterales ydhC ko:K07552,ko:K18552 br01600,ko00000,ko01504,ko02000 2.A.1.2,2.A.1.2.3 Bacteria 1QU36@1224,2KK93@204458,2TVXA@28211,COG0477@1,COG0477@2 NA|NA|NA EGP Sugar (and other) transporter HIMHAPGP_00203 1038858.AXBA01000005_gene4496 5.9e-36 157.1 Xanthobacteraceae yaeJ GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0003824,GO:0004045,GO:0005488,GO:0006412,GO:0006414,GO:0006415,GO:0006417,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016150,GO:0016787,GO:0016788,GO:0019222,GO:0019538,GO:0022411,GO:0031323,GO:0031326,GO:0032268,GO:0032984,GO:0034248,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0052689,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0140098,GO:0140101,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112 ko:K15034 ko00000,ko03012 Bacteria 1RH75@1224,2U9M7@28211,3EZSG@335928,COG1186@1,COG1186@2 NA|NA|NA J RF-1 domain HIMHAPGP_00204 452662.SJA_C1-19550 4.7e-24 117.5 Sphingomonadales Bacteria 1NIHT@1224,2EQ70@1,2K5XI@204457,2UK3J@28211,33HT9@2 NA|NA|NA HIMHAPGP_00205 1280948.HY36_11225 2.1e-70 272.3 Hyphomonadaceae nth GO:0000702,GO:0000703,GO:0003674,GO:0003824,GO:0003906,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0034644,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071214,GO:0071478,GO:0071482,GO:0071704,GO:0090304,GO:0104004,GO:0140097,GO:1901360 4.2.99.18 ko:K10773 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 1MUYQ@1224,2TRI2@28211,43W70@69657,COG0177@1,COG0177@2 NA|NA|NA L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate HIMHAPGP_00206 1123240.ATVO01000009_gene717 2.2e-15 89.0 Sphingomonadales Bacteria 1NDDM@1224,2K6XZ@204457,2UHRG@28211,COG5488@1,COG5488@2 NA|NA|NA S Integral membrane protein (DUF2244) HIMHAPGP_00207 452662.SJA_C1-27780 2.6e-62 245.4 Sphingomonadales Bacteria 1RHAE@1224,2K42K@204457,2U5V5@28211,COG2813@1,COG2813@2 NA|NA|NA J Protein of unknown function (DUF938) HIMHAPGP_00208 1537715.JQFJ01000002_gene1883 5.8e-41 173.7 Sphingomonadales ptpA 3.1.3.48 ko:K01104 ko00000,ko01000 Bacteria 1RH90@1224,2K5E1@204457,2U72X@28211,COG0394@1,COG0394@2 NA|NA|NA T Belongs to the low molecular weight phosphotyrosine protein phosphatase family HIMHAPGP_00209 1150626.PHAMO_40030 8.7e-75 287.3 Rhodospirillales ko:K13572 ko00000,ko03051 Bacteria 1R674@1224,2JV3Q@204441,2TTWA@28211,COG2378@1,COG2378@2 NA|NA|NA K WYL domain HIMHAPGP_00211 1248916.ANFY01000003_gene462 1e-37 163.7 Bacteria YH67_14670 Bacteria COG2928@1,COG2928@2 NA|NA|NA S Conserved Protein HIMHAPGP_00212 1333998.M2A_2255 2.7e-213 748.0 Alphaproteobacteria MA20_23085 ko:K10215 ko00627,ko01120,map00627,map01120 R07836,R07837 RC02100,RC03121 ko00000,ko00001,ko01000 Bacteria 1MU71@1224,2TV2E@28211,COG2072@1,COG2072@2 NA|NA|NA P Flavoprotein involved in K transport HIMHAPGP_00213 745310.G432_10015 1.8e-10 72.0 Sphingomonadales Bacteria 1NA2F@1224,297IB@1,2K6A7@204457,2UH54@28211,2ZURJ@2 NA|NA|NA HIMHAPGP_00215 1088721.NSU_1839 8.3e-86 324.3 Sphingomonadales GO:0003674,GO:0003824,GO:0005575,GO:0006082,GO:0006629,GO:0006790,GO:0008146,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016782,GO:0031224,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044272,GO:0044281,GO:0044425,GO:0046505,GO:0046506,GO:0071704,GO:1901576 Bacteria 1QXXG@1224,2KEJ5@204457,2UF0X@28211,COG0446@1,COG0446@2 NA|NA|NA S Sulfotransferase domain HIMHAPGP_00216 1122197.ATWI01000009_gene1505 3e-36 159.1 Proteobacteria Bacteria 1QZB5@1224,2DR3T@1,33A1M@2 NA|NA|NA HIMHAPGP_00217 1123240.ATVO01000003_gene119 6.3e-54 218.0 Sphingomonadales ko:K09973 ko00000 Bacteria 1MVCW@1224,2JZWN@204457,2U5RA@28211,COG3735@1,COG3735@2 NA|NA|NA S protein conserved in bacteria HIMHAPGP_00218 1234595.C725_2476 1.3e-196 692.6 Alphaproteobacteria 6.2.1.3 ko:K00666,ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 Bacteria 1MUIC@1224,2TRRZ@28211,COG0318@1,COG0318@2 NA|NA|NA IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II HIMHAPGP_00219 1248916.ANFY01000004_gene1774 2.6e-51 208.8 Alphaproteobacteria Bacteria 1N0PI@1224,2EN5S@1,2UST7@28211,33FTP@2 NA|NA|NA S PEP-CTERM motif HIMHAPGP_00220 685778.AORL01000014_gene2248 1.1e-129 469.5 Sphingomonadales glyQ GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016874,GO:0016875,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0140098,GO:0140101 6.1.1.14 ko:K01878,ko:K14164 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iAF1260.b3560,iAF987.Gmet_2942,iJO1366.b3560,iPC815.YPO4072,iY75_1357.Y75_RS19360 Bacteria 1MVCJ@1224,2K1RK@204457,2TS2N@28211,COG0752@1,COG0752@2 NA|NA|NA J glycyl-tRNA synthetase alpha subunit HIMHAPGP_00222 1248916.ANFY01000003_gene774 1.3e-64 252.7 Sphingomonadales ilvH GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 iAPECO1_1312.APECO1_1906,iECNA114_1301.ECNA114_0072,iEcSMS35_1347.EcSMS35_0084,iG2583_1286.G2583_0082,iSFxv_1172.SFxv_0077,iUTI89_1310.UTI89_C0086 Bacteria 1RAGN@1224,2K12R@204457,2U5CW@28211,COG0440@1,COG0440@2 NA|NA|NA E acetolactate synthase HIMHAPGP_00223 1550073.JROH01000012_gene2491 1.7e-71 275.4 Sphingomonadales ilvI 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 Bacteria 1MU6U@1224,2K0GG@204457,2TR1I@28211,COG0028@1,COG0028@2 NA|NA|NA EH COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase HIMHAPGP_00224 1248916.ANFY01000014_gene46 3.5e-166 592.0 Sphingomonadales yuxL 3.4.19.1 ko:K01303 ko00000,ko01000,ko01002 Bacteria 1MWGR@1224,2K0PD@204457,2TRTE@28211,COG0823@1,COG0823@2,COG1506@1,COG1506@2 NA|NA|NA EU Prolyl oligopeptidase family HIMHAPGP_00226 1550073.JROH01000028_gene915 6.1e-58 231.1 Sphingomonadales MA20_41470 ko:K06923 ko00000 Bacteria 1MVMX@1224,2K28Z@204457,2TTFE@28211,COG2607@1,COG2607@2 NA|NA|NA P ATPase (AAA superfamily) HIMHAPGP_00227 1367847.JCM7686_0952 2.1e-31 141.7 Paracoccus yajC GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031522,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 Bacteria 1MZT2@1224,2PXDN@265,2UBZ6@28211,COG1862@1,COG1862@2 NA|NA|NA U Preprotein translocase subunit HIMHAPGP_00228 1234595.C725_0040 2e-185 655.6 unclassified Alphaproteobacteria secD ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 Bacteria 1MV5U@1224,2TQYG@28211,4BPMN@82117,COG0342@1,COG0342@2 NA|NA|NA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA HIMHAPGP_00229 627192.SLG_29540 9.8e-103 380.2 Sphingomonadales secF GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 ko:K03072,ko:K03074,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 Bacteria 1MU74@1224,2K18K@204457,2TSFW@28211,COG0341@1,COG0341@2 NA|NA|NA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA HIMHAPGP_00231 1121271.AUCM01000003_gene1664 3.1e-112 411.4 Alphaproteobacteria MA20_36865 Bacteria 1NR18@1224,2TVGP@28211,COG2043@1,COG2043@2 NA|NA|NA S Uncharacterised ArCR, COG2043 HIMHAPGP_00232 1537715.JQFJ01000005_gene67 3e-32 144.4 Sphingomonadales Bacteria 1QATG@1224,2K7AV@204457,2VE9J@28211,COG5591@1,COG5591@2 NA|NA|NA S Peptidase propeptide and YPEB domain HIMHAPGP_00233 1537715.JQFJ01000005_gene68 3.5e-50 204.9 Sphingomonadales msrQ ko:K17247 ko00000 Bacteria 1RDUP@1224,2K7GE@204457,2U5HG@28211,COG2717@1,COG2717@2 NA|NA|NA C Ferric reductase like transmembrane component HIMHAPGP_00234 1537715.JQFJ01000005_gene69 4.8e-96 357.5 Sphingomonadales ybiX GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0019725,GO:0030003,GO:0033554,GO:0042592,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0098771 1.14.11.2 ko:K00472,ko:K07336 ko00330,ko01100,map00330,map01100 R01252 RC00478 ko00000,ko00001,ko01000 Bacteria 1MUI7@1224,2JZZU@204457,2TRH2@28211,COG3128@1,COG3128@2 NA|NA|NA S PKHD-type hydroxylase HIMHAPGP_00235 1123253.AUBD01000013_gene953 1.4e-270 939.1 Xanthomonadales bfrE GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 ko:K16090 ko00000,ko02000 1.B.14.1.11 Bacteria 1MV0X@1224,1RN3C@1236,1X38Y@135614,COG4774@1,COG4774@2 NA|NA|NA P receptor HIMHAPGP_00236 1537715.JQFJ01000005_gene71 7.7e-36 157.5 Sphingomonadales ko:K03832 ko00000,ko02000 2.C.1.1 Bacteria 1PDZ7@1224,2K8BD@204457,2VAPI@28211,COG0810@1,COG0810@2 NA|NA|NA M TonB C terminal HIMHAPGP_00237 1537715.JQFJ01000005_gene72 7.4e-39 166.8 Sphingomonadales exbD GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0023052,GO:0031224,GO:0031226,GO:0031647,GO:0031992,GO:0032991,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0050821,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0065008,GO:0071944,GO:0098796,GO:0098797 ko:K03559,ko:K03560 ko00000,ko02000 1.A.30.2.1,1.A.30.2.2 iPC815.YPO0683 Bacteria 1RDJZ@1224,2KAKP@204457,2U77T@28211,COG0848@1,COG0848@2 NA|NA|NA U Biopolymer transport protein ExbD/TolR HIMHAPGP_00238 46429.BV95_03520 1.7e-70 272.7 Sphingomonadales exbB GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0023052,GO:0031224,GO:0031226,GO:0031647,GO:0031992,GO:0032991,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0050821,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0065008,GO:0071944,GO:0098796,GO:0098797 ko:K03561,ko:K03562 ko01120,map01120 ko00000,ko02000 1.A.30.2.1,1.A.30.2.2 iSBO_1134.SBO_3000,iSbBS512_1146.SbBS512_E3434 Bacteria 1MXHR@1224,2K907@204457,2TQNN@28211,COG0811@1,COG0811@2 NA|NA|NA U MotA/TolQ/ExbB proton channel family HIMHAPGP_00239 1248916.ANFY01000010_gene350 1.5e-59 236.1 Sphingomonadales terC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 1PN8B@1224,2K1SQ@204457,2TUV5@28211,COG0861@1,COG0861@2 NA|NA|NA P membrane protein, TerC HIMHAPGP_00241 1123267.JONN01000002_gene82 1.3e-137 496.1 Sphingomonadales argH GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1MUTU@1224,2K185@204457,2TR4H@28211,COG0165@1,COG0165@2 NA|NA|NA E argininosuccinate lyase HIMHAPGP_00243 1207055.C100_17320 1.3e-144 519.6 Sphingomonadales lysA GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008836,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 iLJ478.TM1517 Bacteria 1MUA6@1224,2JZWD@204457,2TQPB@28211,COG0019@1,COG0019@2 NA|NA|NA E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine HIMHAPGP_00244 1248916.ANFY01000003_gene510 5e-114 417.5 Sphingomonadales galU 2.7.7.9,5.4.2.8 ko:K00963,ko:K01840 ko00040,ko00051,ko00052,ko00500,ko00520,ko01100,ko01110,ko01130,map00040,map00051,map00052,map00500,map00520,map01100,map01110,map01130 M00114,M00129,M00361,M00362,M00549 R00289,R01818 RC00002,RC00408 ko00000,ko00001,ko00002,ko01000 Bacteria 1MV5F@1224,2K1NI@204457,2TRT6@28211,COG1210@1,COG1210@2 NA|NA|NA M UTP-glucose-1-phosphate uridylyltransferase HIMHAPGP_00245 1120705.FG95_02264 1.5e-24 119.4 Sphingomonadales ybbJ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K07340 ko00000 Bacteria 1N241@1224,2K5WQ@204457,2UC8X@28211,COG1585@1,COG1585@2 NA|NA|NA OU Membrane protein implicated in regulation of membrane protease activity HIMHAPGP_00246 1123502.AQXD01000001_gene1169 2.3e-41 175.6 Xanthomonadales qmcA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 1MUM8@1224,1RNW8@1236,1X3MC@135614,COG0330@1,COG0330@2 NA|NA|NA O Membrane HIMHAPGP_00247 1280946.HY29_11770 4.5e-18 96.7 Hyphomonadaceae ygaP Bacteria 1N6NN@1224,2UFC1@28211,32YCZ@2,43YJN@69657,COG0607@1 NA|NA|NA P Protein of unknown function (DUF2892) HIMHAPGP_00248 1114964.L485_18350 2.3e-192 678.3 Sphingomonadales sqr GO:0003674,GO:0003824,GO:0003955,GO:0005488,GO:0005515,GO:0006091,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0019646,GO:0022900,GO:0022904,GO:0042802,GO:0044237,GO:0045333,GO:0055114 1.8.5.4 ko:K17218 ko00920,map00920 R10152 RC03155 ko00000,ko00001,ko01000 Bacteria 1QSG6@1224,2K2NT@204457,2TUP1@28211,COG0446@1,COG0446@2 NA|NA|NA S Pyridine nucleotide-disulphide oxidoreductase HIMHAPGP_00249 627192.SLG_25660 3.6e-28 131.0 Sphingomonadales ytwF Bacteria 1N2R7@1224,2K4M8@204457,2U9G7@28211,COG0607@1,COG0607@2 NA|NA|NA P Rhodanese-like domain HIMHAPGP_00250 983920.Y88_2420 7.5e-61 241.1 Sphingomonadales Bacteria 1MXU4@1224,2K3AT@204457,2TUXB@28211,COG0845@1,COG0845@2 NA|NA|NA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family HIMHAPGP_00251 1174684.EBMC1_09579 0.0 1413.7 Sphingomonadales Bacteria 1MU48@1224,2KCZ7@204457,2TQT0@28211,COG0841@1,COG0841@2 NA|NA|NA V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family HIMHAPGP_00252 450851.PHZ_c0064 1.1e-15 89.7 Caulobacterales ko:K22042 ko00000,ko03000 Bacteria 1N72Q@1224,2KJ72@204458,2UFSY@28211,COG0640@1,COG0640@2 NA|NA|NA K helix_turn_helix, Arsenical Resistance Operon Repressor HIMHAPGP_00253 913325.N799_00910 4.3e-42 177.6 Xanthomonadales 1.8.1.8 ko:K03671,ko:K03672 ko04621,ko05418,map04621,map05418 ko00000,ko00001,ko01000,ko03110 Bacteria 1QU2B@1224,1T1N1@1236,1XD4R@135614,COG0526@1,COG0526@2 NA|NA|NA O Thioredoxin HIMHAPGP_00254 1408418.JNJH01000004_gene1916 1.2e-26 125.9 Rhodospirillales 4.1.1.44 ko:K01607 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 R03470 RC00938 ko00000,ko00001,ko01000 Bacteria 1MZ80@1224,2JTBN@204441,2UDE8@28211,COG0599@1,COG0599@2 NA|NA|NA S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity HIMHAPGP_00255 1449076.JOOE01000001_gene2240 5.5e-141 507.3 Sphingomonadales allD 1.1.1.338,1.5.1.21 ko:K13609,ko:K16844 ko00270,ko00310,ko00960,ko01100,ko01120,map00270,map00310,map00960,map01100,map01120 R02203,R07137 RC00031,RC00135 ko00000,ko00001,ko01000 Bacteria 1MWQY@1224,2K2DZ@204457,2TR37@28211,COG2055@1,COG2055@2 NA|NA|NA C Belongs to the LDH2 MDH2 oxidoreductase family HIMHAPGP_00256 1174684.EBMC1_10289 6.6e-235 820.1 Sphingomonadales Bacteria 1MWWY@1224,2JZXP@204457,2TSZZ@28211,COG3653@1,COG3653@2 NA|NA|NA Q COG3653 N-acyl-D-aspartate D-glutamate deacylase HIMHAPGP_00257 414684.RC1_1863 3.4e-85 323.2 Alphaproteobacteria ko:K02014 ko00000,ko02000 1.B.14 Bacteria 1MWKN@1224,2TWXF@28211,COG1629@1,COG4771@2 NA|NA|NA P TonB dependent receptor HIMHAPGP_00258 1122970.AUHC01000007_gene1790 5.1e-93 347.8 Sphingomonadales Bacteria 1QTHN@1224,2K90P@204457,2U6MZ@28211,2Z8YY@2,KOG1110@1 NA|NA|NA S Protein of unknown function (DUF1838) HIMHAPGP_00259 1144305.PMI02_01411 9.1e-85 321.2 Sphingomonadales ko:K03929 ko00000,ko01000 CE10 Bacteria 1MVQZ@1224,2K1A5@204457,2TUA9@28211,COG2272@1,COG2272@2 NA|NA|NA I Belongs to the type-B carboxylesterase lipase family HIMHAPGP_00260 1125973.JNLC01000011_gene372 1.2e-21 110.9 Bradyrhizobiaceae lytT ko:K02477,ko:K07705 ko02020,map02020 M00492 ko00000,ko00001,ko00002,ko02022 Bacteria 1Q4EP@1224,2VAWN@28211,3K5R0@41294,COG3279@1,COG3279@2 NA|NA|NA KT LytTr DNA-binding domain HIMHAPGP_00261 1248916.ANFY01000003_gene524 5.8e-25 120.2 Sphingomonadales 3.4.16.4 ko:K01286,ko:K07258 ko00550,ko01100,map00550,map01100 ko00000,ko00001,ko01000,ko01002,ko01011 Bacteria 1MUU7@1224,2K3S5@204457,2TRCV@28211,COG1686@1,COG1686@2 NA|NA|NA M D-alanyl-D-alanine carboxypeptidase HIMHAPGP_00262 1112214.AHIS01000077_gene3809 2.2e-150 538.9 Sphingomonadales mntH Bacteria 1MW6X@1224,2K3P4@204457,2TRNM@28211,COG1914@1,COG1914@2 NA|NA|NA P Natural resistance-associated macrophage protein HIMHAPGP_00263 69395.JQLZ01000006_gene2204 2.5e-30 139.0 Caulobacterales Bacteria 1RFIR@1224,2KIQ6@204458,2U8S6@28211,COG3714@1,COG3714@2 NA|NA|NA S YhhN family HIMHAPGP_00264 627192.SLG_27430 2.7e-35 155.2 Sphingomonadales ko:K09983 ko00000 Bacteria 1RGUV@1224,2K5DU@204457,2U9BA@28211,COG3812@1,COG3812@2 NA|NA|NA S Domain of unknown function (DUF1993) HIMHAPGP_00265 1123267.JONN01000001_gene1200 2.8e-157 562.4 Sphingomonadales dnaE GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 1MUIF@1224,2K1R8@204457,2TSCN@28211,COG0587@1,COG0587@2 NA|NA|NA L DNA polymerase HIMHAPGP_00266 1174684.EBMC1_07770 1.2e-115 423.3 Sphingomonadales gp36 Bacteria 1MWU1@1224,2K0P2@204457,2TSSY@28211,COG4653@1,COG4653@2 NA|NA|NA S phage phi-C31 gp36 major capsid-like protein HIMHAPGP_00267 685778.AORL01000016_gene2336 4.5e-27 127.5 Sphingomonadales gp35 ko:K06904 ko00000 Bacteria 1N2D8@1224,2K6IB@204457,2UD3U@28211,COG3740@1,COG3740@2 NA|NA|NA S Phage head maturation protease HIMHAPGP_00268 685778.AORL01000016_gene2334 1.1e-102 380.2 Sphingomonadales Bacteria 1MUP5@1224,2JZVE@204457,2TT33@28211,COG4695@1,COG4695@2 NA|NA|NA S portal protein HIMHAPGP_00270 685778.AORL01000016_gene2333 5.1e-131 474.6 Sphingomonadales Bacteria 1MW8S@1224,2K2BG@204457,2TREI@28211,COG5323@1,COG5323@2 NA|NA|NA S Terminase RNaseH-like domain HIMHAPGP_00271 1174684.EBMC1_14902 4.9e-37 161.0 Sphingomonadales Bacteria 1MXC9@1224,2K5KF@204457,2TTTY@28211,COG0583@1,COG0583@2 NA|NA|NA K DNA-binding transcription factor activity HIMHAPGP_00272 1522072.IL54_4138 2.9e-51 208.4 Sphingomonadales Bacteria 1RKW7@1224,2K2H6@204457,2U9PU@28211,COG1396@1,COG1396@2 NA|NA|NA K XRE family transcriptional regulator HIMHAPGP_00273 745310.G432_10605 0.0 1096.6 Sphingomonadales thrS 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 1MUP2@1224,2K14B@204457,2TQWI@28211,COG0441@1,COG0441@2 NA|NA|NA J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) HIMHAPGP_00274 1090319.KE386571_gene2570 2.9e-30 138.3 Sphingomonadales blh 1.8.5.4 ko:K17218 ko00920,map00920 R10152 RC03155 ko00000,ko00001,ko01000 Bacteria 1N9AF@1224,2K56H@204457,2UD2M@28211,COG3453@1,COG3453@2 NA|NA|NA S protein conserved in bacteria HIMHAPGP_00275 392499.Swit_2922 7.3e-203 713.4 Sphingomonadales Bacteria 1R40Z@1224,2K09C@204457,2U85Z@28211,COG1228@1,COG1228@2 NA|NA|NA Q Amidohydrolase family HIMHAPGP_00276 1101191.KI912577_gene1423 3.7e-96 358.6 Methylobacteriaceae MA20_18180 ko:K07001 ko00000 Bacteria 1JZ1Q@119045,1MVHW@1224,2TS4V@28211,COG1752@1,COG1752@2 NA|NA|NA S PFAM Patatin HIMHAPGP_00277 1123240.ATVO01000005_gene1930 3.9e-88 332.0 Sphingomonadales Bacteria 1QURG@1224,2K08C@204457,2TS62@28211,COG0683@1,COG0683@2 NA|NA|NA E Extracellular ligand-binding receptor HIMHAPGP_00278 13690.CP98_00273 6.5e-82 310.8 Sphingomonadales rsmI GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.198 ko:K07056 ko00000,ko01000,ko03009 Bacteria 1MU0E@1224,2K0AW@204457,2TR14@28211,COG0313@1,COG0313@2 NA|NA|NA H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA HIMHAPGP_00279 745310.G432_02520 1.2e-18 99.4 Sphingomonadales MA20_24645 ko:K07460 ko00000 Bacteria 1N6VN@1224,2K62R@204457,2UFTM@28211,COG0792@1,COG0792@2 NA|NA|NA L Belongs to the UPF0102 family HIMHAPGP_00280 745310.G432_02525 5.1e-120 437.6 Sphingomonadales gshB GO:0000287,GO:0003674,GO:0003824,GO:0004363,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0019184,GO:0034641,GO:0042398,GO:0042601,GO:0042763,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:1901564,GO:1901566,GO:1901576 6.3.2.2,6.3.2.3 ko:K01919,ko:K01920 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00497,R00894,R10993,R10994 RC00064,RC00090,RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 iECED1_1282.ECED1_3410,iECP_1309.ECP_2941,iJN678.gshB Bacteria 1MVUA@1224,2K0JQ@204457,2TQNE@28211,COG0189@1,COG0189@2 NA|NA|NA H Belongs to the prokaryotic GSH synthase family HIMHAPGP_00281 1030157.AFMP01000044_gene1930 1.9e-51 209.1 Sphingomonadales apl 3.1.3.1 ko:K01077 ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020 M00126 R02135,R04620 RC00017 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 Bacteria 1MX4M@1224,2K1Q0@204457,2U6ZF@28211,COG0586@1,COG0586@2 NA|NA|NA S membrane-associated protein HIMHAPGP_00282 190650.CC_0189 3.3e-15 87.0 Caulobacterales MA20_32275 Bacteria 1N7F4@1224,2KH74@204458,2UFVF@28211,COG4391@1,COG4391@2 NA|NA|NA S Zinc-finger domain HIMHAPGP_00283 1123256.KB907932_gene3008 3.1e-46 191.4 Gammaproteobacteria Bacteria 1RFQ0@1224,1SS3G@1236,COG2030@1,COG2030@2 NA|NA|NA I N-terminal half of MaoC dehydratase HIMHAPGP_00284 1219045.BV98_001280 3.5e-31 142.1 Sphingomonadales 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 Bacteria 1NQAE@1224,2K1RF@204457,2U0TJ@28211,COG1960@1,COG1960@2 NA|NA|NA I Acyl-CoA dehydrogenase, C-terminal domain HIMHAPGP_00285 1219045.BV98_001279 3.1e-135 488.4 Sphingomonadales 1.3.8.6,1.3.8.7 ko:K00249,ko:K00252 ko00071,ko00280,ko00310,ko00362,ko00380,ko00410,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00310,map00362,map00380,map00410,map00640,map01100,map01110,map01120,map01130,map01200,map01212,map03320 M00013,M00032,M00036,M00087 R00924,R01175,R01279,R02487,R02488,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754,R10074 RC00052,RC00068,RC00076,RC00095,RC00148,RC00156,RC00246 ko00000,ko00001,ko00002,ko01000 Bacteria 1MW0F@1224,2K12Q@204457,2TR9I@28211,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase HIMHAPGP_00286 1292034.OR37_01172 3.5e-167 595.1 Caulobacterales cysC 2.7.1.25,2.7.7.4 ko:K00860,ko:K00955,ko:K00956 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00509,R00529,R04928,R04929 RC00002,RC00078,RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUD9@1224,2KF08@204458,2TQNJ@28211,COG0529@1,COG0529@2,COG2895@1,COG2895@2 NA|NA|NA H Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily HIMHAPGP_00287 1054213.HMPREF9946_04883 1.9e-59 235.3 Bacteria flgK 3.5.1.56 ko:K02388,ko:K02390,ko:K02396,ko:K03418,ko:K07004,ko:K21012 ko00630,ko02025,ko02040,map00630,map02025,map02040 R02509 RC00111,RC00731 ko00000,ko00001,ko01000,ko02035 Bacteria COG1749@1,COG1749@2 NA|NA|NA N bacterial-type flagellum-dependent cell motility HIMHAPGP_00288 1123240.ATVO01000004_gene900 4.2e-112 411.0 Sphingomonadales leuA 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS10690,iYO844.BSU28280 Bacteria 1MUNQ@1224,2K1S1@204457,2TSCJ@28211,COG0119@1,COG0119@2 NA|NA|NA E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) HIMHAPGP_00289 1121004.ATVC01000005_gene1407 1.7e-15 89.4 Betaproteobacteria mliC GO:0003674,GO:0004857,GO:0005575,GO:0005623,GO:0008150,GO:0009279,GO:0016020,GO:0019867,GO:0030234,GO:0030312,GO:0030313,GO:0031975,GO:0043086,GO:0044092,GO:0044462,GO:0044464,GO:0050790,GO:0060241,GO:0065007,GO:0065009,GO:0071944,GO:0098772 Bacteria 1N7GH@1224,2VW47@28216,COG3895@1,COG3895@2 NA|NA|NA S Membrane-bound lysozyme-inhibitor of c-type lysozyme HIMHAPGP_00290 1121004.ATVC01000005_gene1407 4.6e-08 65.1 Betaproteobacteria mliC GO:0003674,GO:0004857,GO:0005575,GO:0005623,GO:0008150,GO:0009279,GO:0016020,GO:0019867,GO:0030234,GO:0030312,GO:0030313,GO:0031975,GO:0043086,GO:0044092,GO:0044462,GO:0044464,GO:0050790,GO:0060241,GO:0065007,GO:0065009,GO:0071944,GO:0098772 Bacteria 1N7GH@1224,2VW47@28216,COG3895@1,COG3895@2 NA|NA|NA S Membrane-bound lysozyme-inhibitor of c-type lysozyme HIMHAPGP_00291 1219049.SP5_005_00420 1.3e-161 576.6 Sphingomonadales mutL GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 ko:K03572 ko03430,map03430 ko00000,ko00001,ko03400 Bacteria 1MV61@1224,2K2AP@204457,2TR2M@28211,COG0323@1,COG0323@2 NA|NA|NA L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex HIMHAPGP_00292 685778.AORL01000021_gene662 3.2e-156 558.1 Sphingomonadales mreB ko:K03569 ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 Bacteria 1MUMW@1224,2K10A@204457,2TTQ2@28211,COG1077@1,COG1077@2 NA|NA|NA D rod shape-determining protein MreB HIMHAPGP_00293 1248916.ANFY01000008_gene2056 7.8e-47 194.5 Sphingomonadales mreC GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007163,GO:0008150,GO:0008360,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0030428,GO:0031224,GO:0031226,GO:0042546,GO:0043621,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071554,GO:0071840,GO:0071944,GO:0071963 ko:K03570 ko00000,ko03036 9.B.157.1 Bacteria 1N8ZS@1224,2K18A@204457,2U1FY@28211,COG1792@1,COG1792@2 NA|NA|NA M Involved in formation and maintenance of cell shape HIMHAPGP_00294 1123240.ATVO01000010_gene661 1.2e-11 76.6 Alphaproteobacteria ko:K03571 ko00000,ko03036 9.B.157.1 Bacteria 1NHX1@1224,2923J@1,2UC0M@28211,2ZPNK@2 NA|NA|NA S rod shape-determining protein MreD HIMHAPGP_00295 1248916.ANFY01000008_gene2054 6.3e-178 630.9 Sphingomonadales mrdA GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 ko00000,ko00001,ko01000,ko01011 iAF987.Gmet_0928,iEcE24377_1341.EcE24377A_0661,iPC815.YPO2604 Bacteria 1MV8C@1224,2JZYI@204457,2TRXN@28211,COG0768@1,COG0768@2 NA|NA|NA M Penicillin-binding Protein HIMHAPGP_00296 13690.CP98_04717 8.5e-119 433.7 Sphingomonadales mrdB GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008360,GO:0016020,GO:0022603,GO:0022604,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944 ko:K05837 ko00000,ko03036 Bacteria 1MUK3@1224,2K0FR@204457,2TSM0@28211,COG0772@1,COG0772@2 NA|NA|NA M Peptidoglycan polymerase that is essential for cell wall elongation HIMHAPGP_00298 1112212.JH584235_gene3079 5.4e-249 866.7 Sphingomonadales cat1 GO:0003674,GO:0003824,GO:0003986,GO:0006082,GO:0006083,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008410,GO:0008775,GO:0009987,GO:0016289,GO:0016740,GO:0016782,GO:0016787,GO:0016788,GO:0016790,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0043821,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0046459,GO:0071704 2.8.3.18,3.1.2.1 ko:K01067,ko:K18118,ko:K22214 ko00020,ko00620,ko00640,ko00650,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00640,map00650,map01100,map01110,map01120,map01130,map01200 M00009,M00011 R00227,R10343,R11773 RC00004,RC00012,RC00014 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1125,iECIAI1_1343.ECIAI1_3040,iECSE_1348.ECSE_3182,iECW_1372.ECW_m3175,iEKO11_1354.EKO11_0812,iWFL_1372.ECW_m3175 Bacteria 1MUGE@1224,2K0X0@204457,2TQYS@28211,COG0427@1,COG0427@2 NA|NA|NA C acetyl-CoA hydrolase HIMHAPGP_00299 1123392.AQWL01000002_gene1698 0.0 1172.5 Hydrogenophilales pacL2 3.6.3.8 ko:K01537 ko00000,ko01000 3.A.3.2 Bacteria 1KS0K@119069,1MUU5@1224,2VH2F@28216,COG0474@1,COG0474@2 NA|NA|NA P Cation transporter/ATPase, N-terminus HIMHAPGP_00300 159087.Daro_1671 5.3e-98 364.0 Rhodocyclales hrtA ko:K02003,ko:K09814 ko02010,map02010 M00257,M00258 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1 Bacteria 1MXVW@1224,2KXRM@206389,2VI95@28216,COG1136@1,COG1136@2 NA|NA|NA V ABC transporter HIMHAPGP_00301 525897.Dbac_1924 1.4e-40 172.2 Deltaproteobacteria ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 1MVSU@1224,2WMAW@28221,42NKX@68525,COG0577@1,COG0577@2 NA|NA|NA V ABC-type transport system involved in lipoprotein release permease component HIMHAPGP_00302 1248916.ANFY01000009_gene175 6.8e-159 567.0 Sphingomonadales carA GO:0000050,GO:0003674,GO:0003824,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0032991,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 iAPECO1_1312.APECO1_1950,iNJ661.Rv1383,iUTI89_1310.UTI89_C0036,ic_1306.c0040 Bacteria 1MUB9@1224,2K02X@204457,2TR3W@28211,COG0505@1,COG0505@2 NA|NA|NA F Belongs to the CarA family HIMHAPGP_00303 745310.G432_00670 2.4e-51 208.4 Sphingomonadales yqeY ko:K09117 ko00000 Bacteria 1RGZS@1224,2K3W5@204457,2U7DJ@28211,COG1610@1,COG1610@2 NA|NA|NA S Yqey-like protein HIMHAPGP_00304 1123240.ATVO01000003_gene420 5.7e-141 508.1 Sphingomonadales dnaG ko:K02316 ko03030,map03030 ko00000,ko00001,ko01000,ko03032 Bacteria 1MUHC@1224,2K0VR@204457,2TRU2@28211,COG0358@1,COG0358@2 NA|NA|NA L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication HIMHAPGP_00307 1122137.AQXF01000003_gene1942 9e-90 336.7 Alphaproteobacteria 1.13.12.16 ko:K00459,ko:K15329 ko00910,map00910 R00025 RC02541,RC02759 ko00000,ko00001,ko01000,ko01008 Bacteria 1MU0U@1224,2TS5U@28211,COG2070@1,COG2070@2 NA|NA|NA S 2-nitropropane dioxygenase HIMHAPGP_00308 1248916.ANFY01000004_gene1669 1.6e-206 725.7 Sphingomonadales Bacteria 1MV19@1224,2K0FF@204457,2TQKQ@28211,COG2303@1,COG2303@2 NA|NA|NA E Belongs to the GMC oxidoreductase family HIMHAPGP_00309 1123240.ATVO01000006_gene1510 3.5e-160 571.2 Sphingomonadales 3.3.2.9 ko:K01253,ko:K21159 ko00980,ko01059,ko04976,ko05204,map00980,map01059,map04976,map05204 R07013,R07014,R07027,R07071,R07072,R07082,R09410,R09417,R09443 RC01447,RC01728,RC01764,RC02528 ko00000,ko00001,ko01000,ko01002 Bacteria 1MWVN@1224,2K2FR@204457,2TQVB@28211,COG0596@1,COG0596@2 NA|NA|NA I epoxide hydrolase HIMHAPGP_00310 1248916.ANFY01000003_gene584 2.2e-61 242.7 Sphingomonadales Bacteria 1RCED@1224,2K1CY@204457,2U66Q@28211,COG0697@1,COG0697@2 NA|NA|NA EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily HIMHAPGP_00311 69279.BG36_14025 3.2e-94 351.7 Phyllobacteriaceae prsA 5.2.1.8 ko:K03769,ko:K03770 ko00000,ko01000,ko03110 Bacteria 1RDD3@1224,2U3I3@28211,43M1J@69277,COG0760@1,COG0760@2 NA|NA|NA O peptidyl-prolyl isomerase HIMHAPGP_00312 69279.BG36_12935 5.2e-101 374.0 Phyllobacteriaceae narI GO:0001666,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006950,GO:0008150,GO:0008152,GO:0008940,GO:0009055,GO:0009061,GO:0009628,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016661,GO:0019645,GO:0020037,GO:0022900,GO:0022904,GO:0036293,GO:0044237,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0050896,GO:0055114,GO:0070482,GO:0071944,GO:0097159,GO:1901363 1.7.5.1 ko:K00370,ko:K00374,ko:K02575 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00615,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 2.A.1.8,5.A.3.1 iNJ661.Rv1164 Bacteria 1MXGZ@1224,2TTDB@28211,43K9Z@69277,COG2181@1,COG2181@2 NA|NA|NA C nitrate reductase HIMHAPGP_00313 69279.BG36_14015 5.5e-92 344.0 Phyllobacteriaceae narJ GO:0001666,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009987,GO:0016043,GO:0016530,GO:0022607,GO:0034622,GO:0036293,GO:0042126,GO:0042128,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0050896,GO:0051131,GO:0065003,GO:0070482,GO:0071704,GO:0071840,GO:0071941,GO:0140104,GO:2001057 1.7.5.1 ko:K00370,ko:K00373,ko:K17052 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.8 iE2348C_1286.E2348C_1350,iECABU_c1320.ECABU_c15020,iECIAI1_1343.ECIAI1_1469,iECO103_1326.ECO103_1331,iECO111_1330.ECO111_1557,iECW_1372.ECW_m1594,iEKO11_1354.EKO11_2354,iLF82_1304.LF82_1462,iNRG857_1313.NRG857_06280,iSSON_1240.SSON_1659,iWFL_1372.ECW_m1594,iYO844.BSU37260,ic_1306.c1687 Bacteria 1MY4E@1224,2U19T@28211,43KWJ@69277,COG2180@1,COG2180@2 NA|NA|NA C Nitrate reductase HIMHAPGP_00314 69279.BG36_12945 5.1e-102 377.1 Phyllobacteriaceae narH GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006091,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008940,GO:0009055,GO:0009061,GO:0009325,GO:0009898,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016661,GO:0019645,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0031235,GO:0032991,GO:0033554,GO:0042126,GO:0043436,GO:0044237,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0044799,GO:0045333,GO:0048037,GO:0050896,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204,GO:2001057 1.7.5.1 ko:K00371 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000 5.A.3.1 iAF987.Gmet_1021,iEcE24377_1341.EcE24377A_1376,iEcolC_1368.EcolC_2189 Bacteria 1MW9Q@1224,2VC75@28211,43GQD@69277,COG1140@1,COG1140@2 NA|NA|NA C one of 3 nitrate reductases in E. coli and in E. coli is expressed when nitrate levels are high HIMHAPGP_00315 391600.ABRU01000039_gene1982 6.9e-81 307.0 Caulobacterales cysK_2 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUR6@1224,2KF10@204458,2TRHT@28211,COG0031@1,COG0031@2 NA|NA|NA E Pyridoxal-phosphate dependent enzyme HIMHAPGP_00316 1323663.AROI01000008_gene2637 2.4e-88 332.4 Gammaproteobacteria Bacteria 1R5D8@1224,1RYEI@1236,COG2207@1,COG2207@2 NA|NA|NA K AraC family transcriptional regulator HIMHAPGP_00317 1549858.MC45_11685 1.2e-91 342.8 Sphingomonadales purQ GO:0003674,GO:0003824,GO:0004642,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 Bacteria 1MU4Y@1224,2K0NC@204457,2TS67@28211,COG0047@1,COG0047@2 NA|NA|NA F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL HIMHAPGP_00318 314225.ELI_02445 3.5e-20 104.0 Sphingomonadales purS 6.3.2.6,6.3.5.3 ko:K01923,ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463,R04591 RC00010,RC00064,RC00162,RC01160 ko00000,ko00001,ko00002,ko01000 iYO844.BSU06460 Bacteria 1N83G@1224,2K5YV@204457,2UF7S@28211,COG1828@1,COG1828@2 NA|NA|NA F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL HIMHAPGP_00319 709797.CSIRO_2970 8.3e-32 144.4 Bradyrhizobiaceae MA20_16335 5.3.3.18 ko:K15866 ko00360,ko01120,map00360,map01120 R09837,R09839 RC00004,RC00326,RC02689,RC03003 ko00000,ko00001,ko01000 iAF987.Gmet_2224 Bacteria 1MWF6@1224,2TVBC@28211,3JSPF@41294,COG1024@1,COG1024@2 NA|NA|NA I Enoyl-CoA hydratase/isomerase HIMHAPGP_00320 123899.JPQP01000001_gene1722 2.8e-49 202.2 Alcaligenaceae 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 Bacteria 1R446@1224,2VQJ4@28216,3T6YM@506,COG1024@1,COG1024@2 NA|NA|NA I Enoyl-CoA hydratase/isomerase HIMHAPGP_00321 1215114.BBIU01000004_gene539 1e-21 110.9 Gammaproteobacteria ko:K03566 ko02026,map02026 ko00000,ko00001,ko03000 Bacteria 1MYF9@1224,1SYCC@1236,COG0583@1,COG0583@2 NA|NA|NA K Transcriptional regulator HIMHAPGP_00322 1120983.KB894573_gene84 1.8e-96 359.4 Rhodobiaceae npd 1.13.12.16 ko:K00459,ko:K15329 ko00910,map00910 R00025 RC02541,RC02759 ko00000,ko00001,ko01000,ko01008 Bacteria 1JPQY@119043,1MU0U@1224,2TS5U@28211,COG2070@1,COG2070@2 NA|NA|NA S FMN-dependent dehydrogenase HIMHAPGP_00323 264198.Reut_C6056 6.1e-128 464.5 Burkholderiaceae 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 Bacteria 1K4JS@119060,1MUIC@1224,2VI72@28216,COG0318@1,COG0318@2 NA|NA|NA IQ AMP-binding enzyme C-terminal domain HIMHAPGP_00324 1280954.HPO_05717 1.3e-33 151.0 Hyphomonadaceae ko:K03292 ko00000 2.A.2 Bacteria 1MVUM@1224,2U1DI@28211,43Y8J@69657,COG2211@1,COG2211@2 NA|NA|NA G Major facilitator HIMHAPGP_00325 509190.Cseg_1848 2.9e-66 258.8 Caulobacterales tolB ko:K03641 ko00000,ko02000 2.C.1.2 Bacteria 1QVGM@1224,2KJS0@204458,2TWFQ@28211,COG1228@1,COG1228@2,COG4946@1,COG4946@2 NA|NA|NA Q Amidohydrolase family HIMHAPGP_00326 1248916.ANFY01000007_gene2393 2.6e-31 142.1 Sphingomonadales tlpA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 1MZ5J@1224,2K5QM@204457,2TR0C@28211,COG0526@1,COG0526@2 NA|NA|NA CO Redoxin HIMHAPGP_00327 1123240.ATVO01000004_gene1107 3.6e-51 208.8 Sphingomonadales lppB ko:K06194 ko00000 1.A.34.1.2 Bacteria 1RD24@1224,2K0K8@204457,2TUNI@28211,COG4942@1,COG4942@2 NA|NA|NA DM COG0739 Membrane proteins related to metalloendopeptidases HIMHAPGP_00329 1007104.SUS17_1161 0.0 1234.9 Sphingomonadales gyrA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0018130,GO:0019438,GO:0032774,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042493,GO:0042623,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097659,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 ko:K02469 ko00000,ko01000,ko03032,ko03400 Bacteria 1MUGG@1224,2K02J@204457,2TSPQ@28211,COG0188@1,COG0188@2 NA|NA|NA L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner HIMHAPGP_00330 383381.EH30_09005 1.2e-135 489.6 Sphingomonadales tsaD GO:0000287,GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140030,GO:0140032,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 ko:K01409,ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 R10648 RC00070,RC00416 ko00000,ko00001,ko00002,ko01000,ko02044,ko03016 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 Bacteria 1MU6S@1224,2K0S9@204457,2TSF7@28211,COG0533@1,COG0533@2 NA|NA|NA O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction HIMHAPGP_00331 392499.Swit_1932 7.3e-98 364.0 Sphingomonadales gpsA 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 R00842,R00844 RC00029 ko00000,ko00001,ko01000 Bacteria 1MUU3@1224,2K0GB@204457,2TT75@28211,COG0240@1,COG0240@2 NA|NA|NA I Glycerol-3-phosphate dehydrogenase HIMHAPGP_00332 1123240.ATVO01000005_gene1999 1.2e-56 225.7 Sphingomonadales Bacteria 1RH8G@1224,2K5AH@204457,2U9BR@28211,COG0346@1,COG0346@2 NA|NA|NA E COG0346 Lactoylglutathione lyase and related lyases HIMHAPGP_00333 1522072.IL54_1490 6.2e-61 241.1 Bacteria ko:K07052 ko00000 Bacteria COG1266@1,COG1266@2 NA|NA|NA V CAAX protease self-immunity HIMHAPGP_00334 1307834.BARL01000006_gene2930 6.2e-36 157.5 Proteobacteria Bacteria 1NMQY@1224,2EKJU@1,33E9P@2 NA|NA|NA HIMHAPGP_00335 1307834.BARL01000006_gene2931 7.3e-35 153.3 Proteobacteria ko:K10947 ko00000,ko03000 Bacteria 1N0PH@1224,COG1695@1,COG1695@2 NA|NA|NA K Transcriptional regulator HIMHAPGP_00336 1248916.ANFY01000007_gene2265 2.9e-144 518.8 Sphingomonadales ftsZ GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 ko:K03531 ko04112,map04112 ko00000,ko00001,ko02048,ko03036,ko04812 Bacteria 1MV2X@1224,2K16V@204457,2TS1Q@28211,COG0206@1,COG0206@2 NA|NA|NA D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity HIMHAPGP_00337 745310.G432_05520 4.2e-109 401.7 Sphingomonadales ftsA ko:K03590 ko04112,map04112 ko00000,ko00001,ko03036,ko04812 Bacteria 1MUSR@1224,2K082@204457,2TQZB@28211,COG0849@1,COG0849@2 NA|NA|NA D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring HIMHAPGP_00338 1234595.C725_2416 2.5e-50 206.1 Alphaproteobacteria ftsQ GO:0000003,GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0019954,GO:0022402,GO:0022414,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032505,GO:0032506,GO:0040007,GO:0042802,GO:0043093,GO:0044085,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047 6.3.2.4 ko:K01921,ko:K03589,ko:K06438 ko00473,ko00550,ko01100,ko01502,ko04112,map00473,map00550,map01100,map01502,map04112 R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011,ko03036 Bacteria 1MY1Q@1224,2TQPU@28211,COG1589@1,COG1589@2 NA|NA|NA D Cell division protein FtsQ HIMHAPGP_00339 1248916.ANFY01000007_gene2262 1.8e-122 445.7 Sphingomonadales ddl GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008716,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 1.3.1.98,6.3.2.4 ko:K00075,ko:K01921 ko00473,ko00520,ko00550,ko01100,ko01502,map00473,map00520,map00550,map01100,map01502 R01150,R03191,R03192 RC00064,RC00141,RC02639 ko00000,ko00001,ko01000,ko01011 iECO26_1355.ECO26_0095 Bacteria 1MUTB@1224,2K0W3@204457,2TREC@28211,COG1181@1,COG1181@2 NA|NA|NA M Cell wall formation HIMHAPGP_00340 13690.CP98_00794 6.1e-123 447.2 Sphingomonadales murB GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008762,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0055114,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 1.3.1.98,6.3.2.4 ko:K00075,ko:K01921 ko00473,ko00520,ko00550,ko01100,ko01502,map00473,map00520,map00550,map01100,map01502 R01150,R03191,R03192 RC00064,RC00141,RC02639 ko00000,ko00001,ko01000,ko01011 Bacteria 1MXDH@1224,2K0QA@204457,2TRQR@28211,COG0812@1,COG0812@2 NA|NA|NA M Cell wall formation HIMHAPGP_00341 1114964.L485_24410 1e-191 676.4 Sphingomonadales murC GO:0000166,GO:0000270,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034645,GO:0035639,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 iECP_1309.ECP_0093,iJN678.murC Bacteria 1MV68@1224,2K03S@204457,2TRT0@28211,COG0773@1,COG0773@2 NA|NA|NA M Belongs to the MurCDEF family HIMHAPGP_00342 1219049.SP5_075_00030 2e-83 316.2 Sphingomonadales murG GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0050511,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 GT28 iLJ478.TM0232,iSFV_1184.SFV_0083,iSF_1195.SF0087,iSFxv_1172.SFxv_0091,iS_1188.S0089 Bacteria 1MVIB@1224,2K0YF@204457,2TSEY@28211,COG0707@1,COG0707@2 NA|NA|NA M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) HIMHAPGP_00343 1234595.C725_2421 1.2e-115 423.3 unclassified Alphaproteobacteria ftsW GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008360,GO:0009987,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032153,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051179,GO:0051234,GO:0051301,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:1901264,GO:1901505 2.4.1.227 ko:K02563,ko:K03588 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011,ko02000,ko03036 2.A.103.1 GT28 Bacteria 1MVDB@1224,2TQSA@28211,4BPGF@82117,COG0772@1,COG0772@2 NA|NA|NA D Belongs to the SEDS family HIMHAPGP_00344 1030157.AFMP01000032_gene508 1.3e-131 476.5 Sphingomonadales murD 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 Bacteria 1MVYD@1224,2K1GM@204457,2TTE8@28211,COG0771@1,COG0771@2 NA|NA|NA M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) HIMHAPGP_00345 1234595.C725_2423 2.8e-37 161.0 unclassified Alphaproteobacteria mraY GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 iAF987.Gmet_0409,iEC042_1314.EC042_0088,iECABU_c1320.ECABU_c00920,iECED1_1282.ECED1_0088,iECH74115_1262.ECH74115_0095,iECSP_1301.ECSP_0090,iECs_1301.ECs0091,iG2583_1286.G2583_0091,iSDY_1059.SDY_0117,iZ_1308.Z0097,ic_1306.c0105 Bacteria 1MUTK@1224,2TRUG@28211,4BP7F@82117,COG0472@1,COG0472@2 NA|NA|NA M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan HIMHAPGP_00346 1123240.ATVO01000006_gene1599 2.5e-16 92.0 Sphingomonadales Bacteria 1N008@1224,2AM8F@1,2K748@204457,2UCNF@28211,31C39@2 NA|NA|NA HIMHAPGP_00347 1123240.ATVO01000004_gene1111 1.1e-78 300.1 Sphingomonadales Bacteria 1NNHX@1224,2K2C2@204457,2U5HN@28211,COG4798@1,COG4798@2 NA|NA|NA S Methyltransferase HIMHAPGP_00349 1123240.ATVO01000005_gene1787 1.4e-74 287.3 Sphingomonadales ko:K13486 ko02020,map02020 ko00000,ko00001 Bacteria 1R7S3@1224,2KEAR@204457,2U39S@28211,COG5010@1,COG5010@2 NA|NA|NA U COG0457 FOG TPR repeat HIMHAPGP_00350 1123240.ATVO01000003_gene518 2.7e-88 332.0 Sphingomonadales tesB GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016042,GO:0016054,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042802,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046483,GO:0047617,GO:0051186,GO:0055086,GO:0071704,GO:0072329,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901575 ko:K10805 ko01040,map01040 ko00000,ko00001,ko01000,ko01004 Bacteria 1MV9R@1224,2K289@204457,2TRFD@28211,COG1946@1,COG1946@2 NA|NA|NA I Acyl-CoA thioesterase HIMHAPGP_00351 1123269.NX02_27495 1.1e-197 696.0 Sphingomonadales purA GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 Bacteria 1MU5B@1224,2K0T7@204457,2TRKY@28211,COG0104@1,COG0104@2 NA|NA|NA F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP HIMHAPGP_00352 1234595.C725_1099 1e-84 320.5 Alphaproteobacteria hisZ 2.4.2.17,6.1.1.21 ko:K00765,ko:K01892,ko:K02502 ko00340,ko00970,ko01100,ko01110,ko01230,map00340,map00970,map01100,map01110,map01230 M00026,M00359,M00360 R01071,R03655 RC00055,RC00523,RC02819,RC03200 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 1MWIG@1224,2TSVG@28211,COG3705@1,COG3705@2 NA|NA|NA E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine HIMHAPGP_00353 745310.G432_17680 4e-231 807.4 Sphingomonadales serA 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1MU5Z@1224,2K0J0@204457,2TR0F@28211,COG0111@1,COG0111@2 NA|NA|NA E Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family HIMHAPGP_00354 745310.G432_17685 8.2e-154 550.1 Sphingomonadales serC 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 1MUB5@1224,2K0J1@204457,2TSHT@28211,COG1932@1,COG1932@2 NA|NA|NA EH Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine HIMHAPGP_00355 1248916.ANFY01000005_gene2816 1.5e-102 379.4 Sphingomonadales 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 Bacteria 1MU6N@1224,2K00V@204457,2TR90@28211,COG1611@1,COG1611@2 NA|NA|NA S Rossmann fold nucleotide-binding protein HIMHAPGP_00356 1123270.ATUR01000003_gene1140 7.2e-87 327.8 Sphingomonadales dnaX GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0042575,GO:0042802,GO:0043170,GO:0043846,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050790,GO:0061695,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 1MVCK@1224,2K0MV@204457,2TRPB@28211,COG2812@1,COG2812@2 NA|NA|NA L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity HIMHAPGP_00357 1112214.AHIS01000085_gene3676 3.1e-34 151.0 Sphingomonadales ybaB GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:1901363 ko:K06187,ko:K09747 ko03440,map03440 ko00000,ko00001,ko03400 Bacteria 1RGZD@1224,2K5JW@204457,2UBQB@28211,COG0718@1,COG0718@2 NA|NA|NA S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection HIMHAPGP_00358 666684.AfiDRAFT_3635 3.2e-75 288.1 Bradyrhizobiaceae Bacteria 1RD60@1224,2U4T2@28211,3K3PG@41294,COG2191@1,COG2191@2 NA|NA|NA C Formylmethanofuran dehydrogenase, subunit e HIMHAPGP_00359 1234595.C725_2432 3.5e-155 555.1 Alphaproteobacteria MA20_16420 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1MVPC@1224,2VEVD@28211,COG0183@1,COG0183@2 NA|NA|NA I acetyl-coa acetyltransferase HIMHAPGP_00360 1132509.C447_10215 2.9e-56 225.7 Halobacteria 3.1.1.83 ko:K01066,ko:K14731 ko00903,ko00930,ko01220,map00903,map00930,map01220 R03751,R06390,R06391,R06392,R06393 RC00713,RC00983,RC01505 ko00000,ko00001,ko01000 Archaea 23SE7@183963,2XTFN@28890,COG0657@1,arCOG02638@2157 NA|NA|NA I Alpha beta hydrolase HIMHAPGP_00361 1502850.FG91_04022 8.2e-79 300.4 Sphingomonadales Bacteria 1NTYT@1224,2DBBT@1,2K43U@204457,2UQBW@28211,2Z8AC@2 NA|NA|NA S Putative MetA-pathway of phenol degradation HIMHAPGP_00362 1234595.C725_1085 7.6e-149 533.5 unclassified Alphaproteobacteria ftsH GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019222,GO:0019538,GO:0030163,GO:0040007,GO:0042623,GO:0042802,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 ko:K03798 M00742 ko00000,ko00002,ko01000,ko01002,ko03110 Bacteria 1MU6J@1224,2TSYQ@28211,4BPBS@82117,COG0465@1,COG0465@2 NA|NA|NA O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins HIMHAPGP_00363 1370121.AUWS01000073_gene968 1.4e-23 115.2 Mycobacteriaceae Bacteria 233BX@1762,2GJDT@201174,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase HIMHAPGP_00364 1123269.NX02_13835 5.4e-83 314.3 Sphingomonadales ko:K03710 ko00000,ko03000 Bacteria 1MX3T@1224,2K4YK@204457,2TVD7@28211,COG2188@1,COG2188@2 NA|NA|NA K UTRA HIMHAPGP_00365 566466.NOR53_2813 2.1e-61 243.4 Gammaproteobacteria 1.4.3.4 ko:K00274 ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034 M00135 R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354 RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713 ko00000,ko00001,ko00002,ko01000 Bacteria 1RA9M@1224,1S3DF@1236,COG1231@1,COG1231@2 NA|NA|NA E amine oxidase HIMHAPGP_00366 1144305.PMI02_00833 3.7e-22 111.3 Sphingomonadales ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 Bacteria 1MZGS@1224,2K7PI@204457,2UCUT@28211,COG3474@1,COG3474@2 NA|NA|NA C Cytochrome c HIMHAPGP_00367 1123269.NX02_13720 1.2e-66 259.6 Sphingomonadales leuD_2 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1MVXB@1224,2K45W@204457,2VEQM@28211,COG0066@1,COG0066@2 NA|NA|NA E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate HIMHAPGP_00368 1123269.NX02_13725 9.1e-187 659.8 Sphingomonadales leuC 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1MVYR@1224,2K3E6@204457,2TTRS@28211,COG0065@1,COG0065@2 NA|NA|NA E dehydratase, large subunit HIMHAPGP_00369 1123269.NX02_13730 6.2e-163 580.5 Sphingomonadales Bacteria 1MU5U@1224,2K1AJ@204457,2TRIZ@28211,COG1804@1,COG1804@2 NA|NA|NA C CoA-transferase family III HIMHAPGP_00370 1123269.NX02_13735 2.4e-138 498.4 Sphingomonadales 4.1.3.4 ko:K01640 ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146 M00036,M00088 R01360,R08090 RC00502,RC00503,RC01118,RC01946 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUMX@1224,2K262@204457,2TT1R@28211,COG0119@1,COG0119@2 NA|NA|NA E HMGL-like HIMHAPGP_00371 745310.G432_00420 3.5e-115 421.0 Sphingomonadales 3.5.1.107 ko:K13995 ko00760,ko01120,map00760,map01120 M00622 R03540 RC00950 ko00000,ko00001,ko00002,ko01000 Bacteria 1MZUV@1224,2K00R@204457,2U0TK@28211,COG1335@1,COG1335@2 NA|NA|NA Q Isochorismatase HIMHAPGP_00372 629773.AORY01000012_gene821 4.4e-150 537.3 Sphingomonadales Bacteria 1MV3V@1224,2K21Q@204457,2TR0I@28211,COG0726@1,COG0726@2 NA|NA|NA G Polysaccharide deacetylase HIMHAPGP_00373 1248760.ANFZ01000012_gene25 2.8e-123 448.4 Sphingomonadales Bacteria 1MV3V@1224,2K15F@204457,2U6JZ@28211,COG0726@1,COG0726@2 NA|NA|NA G Polysaccharide deacetylase HIMHAPGP_00374 1502850.FG91_00759 3.1e-164 584.7 Sphingomonadales adhB 1.1.1.1,1.1.1.202 ko:K00001,ko:K00086 ko00010,ko00071,ko00350,ko00561,ko00625,ko00626,ko00640,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00561,map00625,map00626,map00640,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 R00623,R00754,R02124,R02377,R03119,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 Bacteria 1MVPH@1224,2K2EM@204457,2TSX8@28211,COG1454@1,COG1454@2 NA|NA|NA C alcohol dehydrogenase HIMHAPGP_00375 652103.Rpdx1_2743 2.9e-132 478.4 Bradyrhizobiaceae MA20_17025 Bacteria 1MV9A@1224,2TTZZ@28211,3JVH5@41294,COG1063@1,COG1063@2 NA|NA|NA E Alcohol dehydrogenase GroES-like domain HIMHAPGP_00376 652103.Rpdx1_2744 2.6e-77 295.4 Bradyrhizobiaceae Bacteria 1MXVZ@1224,2TVJW@28211,3JXVQ@41294,COG1028@1,COG1028@2 NA|NA|NA IQ Enoyl-(Acyl carrier protein) reductase HIMHAPGP_00377 258594.RPA2760 2.8e-209 734.9 Bradyrhizobiaceae 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 Bacteria 1MXDW@1224,2TT9X@28211,3JRKI@41294,COG0028@1,COG0028@2 NA|NA|NA EH Belongs to the TPP enzyme family HIMHAPGP_00378 1248916.ANFY01000003_gene845 4e-217 760.8 Sphingomonadales calB 1.2.1.68 ko:K00154 ko00000,ko01000 Bacteria 1MVGW@1224,2K0D6@204457,2TR9T@28211,COG1012@1,COG1012@2 NA|NA|NA C Belongs to the aldehyde dehydrogenase family HIMHAPGP_00379 1123240.ATVO01000006_gene1521 5.5e-132 477.6 Sphingomonadales dgt GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.1.5.1 ko:K01129 ko00230,map00230 R01856 RC00017 ko00000,ko00001,ko01000 Bacteria 1MVQ2@1224,2K0JG@204457,2TRCD@28211,COG0232@1,COG0232@2 NA|NA|NA F dGTPase family. Type 2 subfamily HIMHAPGP_00380 1234595.C725_2413 2e-160 572.0 Alphaproteobacteria mcr 5.1.99.4 ko:K01796 ko00120,ko01100,ko04146,map00120,map01100,map04146 M00104 R08734,R08739 RC02345 ko00000,ko00001,ko00002,ko01000 Bacteria 1MW1H@1224,2TR7D@28211,COG1804@1,COG1804@2 NA|NA|NA C carnitine dehydratase HIMHAPGP_00381 1174684.EBMC1_05744 1e-70 272.7 Sphingomonadales queF 1.7.1.13 ko:K09457 ko00790,ko01100,map00790,map01100 R07605 RC01875 ko00000,ko00001,ko01000,ko03016 Bacteria 1MW0M@1224,2K3W2@204457,2U57X@28211,COG0780@1,COG0780@2 NA|NA|NA S Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily HIMHAPGP_00384 279238.Saro_2455 5.6e-129 467.6 Sphingomonadales MA20_22910 1.1.1.1,1.3.1.32 ko:K00001,ko:K00217,ko:K13954,ko:K19954 ko00010,ko00071,ko00350,ko00361,ko00362,ko00364,ko00623,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00361,map00362,map00364,map00623,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 R00623,R00754,R02124,R02988,R02989,R04805,R04880,R05233,R05234,R05355,R06848,R06917,R06927,R07105,R07781,R08281,R08306,R08310,R09137,R09138,R09223,R09224 RC00050,RC00087,RC00088,RC00099,RC00107,RC00116,RC00649,RC01335,RC01689,RC01734,RC02273,RC02442 ko00000,ko00001,ko01000 Bacteria 1MVPH@1224,2K2XF@204457,2TSX8@28211,COG1454@1,COG1454@2 NA|NA|NA C Iron-containing alcohol dehydrogenase HIMHAPGP_00385 317655.Sala_2828 1.6e-85 322.8 Sphingomonadales dapD GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008666,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009987,GO:0016053,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016749,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.117,2.3.1.89 ko:K00674,ko:K05822 ko00300,ko01100,ko01110,ko01120,ko01230,map00300,map01100,map01110,map01120,map01230 M00016,M00525 R04364,R04365 RC00004,RC01136 ko00000,ko00001,ko00002,ko01000 iSbBS512_1146.SbBS512_E0158,iYO844.BSU14180 Bacteria 1MU0Y@1224,2K055@204457,2TS3H@28211,COG2171@1,COG2171@2 NA|NA|NA E Belongs to the transferase hexapeptide repeat family HIMHAPGP_00386 745310.G432_08775 9.4e-71 273.5 Sphingomonadales phnX 3.1.3.23,3.11.1.1 ko:K05306,ko:K07025,ko:K19270 ko00440,ko01100,ko01120,map00440,map01100,map01120 R00747 RC00368 ko00000,ko00001,ko01000 Bacteria 1QTWD@1224,2K1QG@204457,2TX5B@28211,COG0637@1,COG0637@2 NA|NA|NA S Haloacid dehalogenase-like hydrolase HIMHAPGP_00387 1123240.ATVO01000006_gene1290 6.5e-81 308.9 Sphingomonadales Bacteria 1MU3S@1224,2K0U8@204457,2U0VY@28211,COG1404@1,COG1404@2 NA|NA|NA O Subtilase family HIMHAPGP_00388 1234595.C725_1766 8.6e-175 620.2 unclassified Alphaproteobacteria dnaB 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 ko00000,ko00001,ko01000,ko03032 Bacteria 1MUG9@1224,2TSF9@28211,4BPP7@82117,COG0305@1,COG0305@2 NA|NA|NA L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins HIMHAPGP_00389 1336235.JAEG01000004_gene3860 4.7e-29 134.0 Rhizobiaceae Bacteria 1MZJ4@1224,2UG35@28211,4BFJ1@82115,COG3152@1,COG3152@2 NA|NA|NA S Protein of unknown function (DUF805) HIMHAPGP_00390 1123240.ATVO01000008_gene2433 1.4e-47 196.1 Sphingomonadales fkpA 5.2.1.8 ko:K01802,ko:K03772,ko:K03773 ko00000,ko01000,ko03110 Bacteria 1RDA1@1224,2K4Y5@204457,2U9XK@28211,COG0545@1,COG0545@2 NA|NA|NA O Peptidyl-prolyl cis-trans HIMHAPGP_00391 1090318.ATTI01000001_gene1752 1.2e-23 115.5 Sphingomonadales rpsU GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 ko:K02970 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1MZA1@1224,2K5X3@204457,2UC58@28211,COG0828@1,COG0828@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bS21 family HIMHAPGP_00392 1090318.ATTI01000001_gene227 2e-54 219.2 Sphingomonadales cOQ9 ko:K18587 ko00000 Bacteria 1MW25@1224,2K3VY@204457,2U9ST@28211,COG5590@1,COG5590@2 NA|NA|NA S RpsU-divergently transcribed HIMHAPGP_00393 1123240.ATVO01000008_gene2436 3.7e-07 60.8 Alphaproteobacteria feoA ko:K04758 ko00000,ko02000 Bacteria 1NASN@1224,2UK64@28211,COG1918@1,COG1918@2 NA|NA|NA P FeoA HIMHAPGP_00394 1123240.ATVO01000008_gene2437 1.9e-214 752.3 Sphingomonadales feoB ko:K04759 ko00000,ko02000 9.A.8.1 Bacteria 1MUZC@1224,2K0AQ@204457,2TQSU@28211,COG0370@1,COG0370@2 NA|NA|NA P Ferrous iron transport protein B HIMHAPGP_00395 1123240.ATVO01000006_gene1609 1.2e-112 412.9 Sphingomonadales tauD 1.14.11.17 ko:K03119 ko00430,ko00920,map00430,map00920 R05320 RC01331 ko00000,ko00001,ko01000 Bacteria 1MV5K@1224,2K2C0@204457,2U38D@28211,COG2175@1,COG2175@2 NA|NA|NA Q taurine catabolism dioxygenase HIMHAPGP_00396 1201035.KE007211_gene533 1.6e-48 199.1 Bartonellaceae ssb ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 ko00000,ko00001,ko03029,ko03032,ko03400 Bacteria 1RCWT@1224,2U5BZ@28211,48TTX@772,COG0629@1,COG0629@2 NA|NA|NA L Single-strand binding protein family HIMHAPGP_00397 633149.Bresu_1957 2.4e-58 231.5 Caulobacterales mce 5.1.99.1 ko:K05606 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R02765,R09979 RC00780,RC02739 ko00000,ko00001,ko00002,ko01000 Bacteria 1RCYU@1224,2KGKT@204458,2U728@28211,COG0346@1,COG0346@2 NA|NA|NA E PFAM Glyoxalase bleomycin resistance protein dioxygenase HIMHAPGP_00398 1248916.ANFY01000004_gene1897 2.7e-14 84.3 Alphaproteobacteria Bacteria 1N6Q5@1224,2UF6W@28211,COG1278@1,COG1278@2 NA|NA|NA K Cold shock HIMHAPGP_00399 1545915.JROG01000004_gene2299 3.9e-17 94.4 Sphingomonadales JD73_18915 Bacteria 1NC23@1224,2K62I@204457,2UGM4@28211,COG1310@1,COG1310@2 NA|NA|NA L metal-dependent protease of the PAD1 JAB1 superfamily HIMHAPGP_00400 1123267.JONN01000002_gene245 1.1e-109 403.3 Sphingomonadales rluD GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.23 ko:K06180 ko00000,ko01000,ko03009 Bacteria 1MUBN@1224,2K1VU@204457,2TSBK@28211,COG0564@1,COG0564@2 NA|NA|NA J Responsible for synthesis of pseudouridine from uracil HIMHAPGP_00402 317655.Sala_0644 7.2e-76 290.0 Sphingomonadales cobS 6.6.1.2 ko:K09882 ko00860,ko01100,map00860,map01100 R05227 RC02000 ko00000,ko00001,ko01000 Bacteria 1MXIW@1224,2K0S6@204457,2TS1Z@28211,COG0714@1,COG0714@2 NA|NA|NA S Aerobic cobaltochelatase subunit CobS HIMHAPGP_00403 1123267.JONN01000001_gene718 1.1e-165 589.7 Sphingomonadales rarA GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0030894,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576 ko:K07478 ko00000 Bacteria 1MUVS@1224,2K1Z2@204457,2TQVF@28211,COG2256@1,COG2256@2 NA|NA|NA L ATPase related to the helicase subunit of the Holliday junction resolvase HIMHAPGP_00404 1234595.C725_3034 1.6e-75 289.7 Alphaproteobacteria Bacteria 1R918@1224,2CF7S@1,2UBK2@28211,32S1E@2 NA|NA|NA HIMHAPGP_00405 715226.ABI_42010 8.4e-23 113.2 Caulobacterales crcB ko:K06199 ko00000,ko02000 1.A.43.1,1.A.43.2,1.A.43.3 Bacteria 1MZNH@1224,2KH2X@204458,2UBUP@28211,COG0239@1,COG0239@2 NA|NA|NA D Important for reducing fluoride concentration in the cell, thus reducing its toxicity HIMHAPGP_00406 1335760.ASTG01000010_gene660 2.1e-122 445.7 Sphingomonadales rluC GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 2.1.1.191,5.4.99.23,5.4.99.24,5.4.99.28,5.4.99.29 ko:K06177,ko:K06179,ko:K06180,ko:K06969 ko00000,ko01000,ko03009,ko03016 Bacteria 1MVDX@1224,2K1YR@204457,2TTQC@28211,COG0564@1,COG0564@2 NA|NA|NA J Responsible for synthesis of pseudouridine from uracil HIMHAPGP_00407 1248916.ANFY01000011_gene1138 1.9e-214 751.9 Sphingomonadales Bacteria 1MW20@1224,2K117@204457,2TQY4@28211,COG0624@1,COG0624@2 NA|NA|NA E Peptidase dimerisation domain HIMHAPGP_00408 1248916.ANFY01000011_gene1142 9.7e-75 286.6 Sphingomonadales gph 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 R01334 RC00017 ko00000,ko00001,ko01000 Bacteria 1RDA7@1224,2K3XQ@204457,2U703@28211,COG0546@1,COG0546@2 NA|NA|NA S Hydrolase HIMHAPGP_00410 392499.Swit_2712 2.2e-51 209.1 Sphingomonadales Bacteria 1Q3B5@1224,2K1FD@204457,2TVK1@28211,COG5387@1,COG5387@2 NA|NA|NA O Chaperone required for the assembly of the mitochondrial F1-ATPase HIMHAPGP_00411 1081640.AGFU01000032_gene2444 9.5e-254 882.5 Sphingomonadales pccB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016421,GO:0016874,GO:0016885,GO:0019752,GO:0031974,GO:0032787,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0070013,GO:0071704,GO:0072329,GO:1901575 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 Bacteria 1MVAX@1224,2K0V7@204457,2TRI1@28211,COG4799@1,COG4799@2 NA|NA|NA I acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) HIMHAPGP_00412 279238.Saro_0809 2.6e-182 644.8 Sphingomonadales thlA 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1MU5G@1224,2JZW1@204457,2TQQ7@28211,COG0183@1,COG0183@2 NA|NA|NA I Belongs to the thiolase family HIMHAPGP_00414 158500.BV97_00419 4.6e-76 290.4 Sphingomonadales mce 5.1.99.1 ko:K05606 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R02765,R09979 RC00780,RC02739 ko00000,ko00001,ko00002,ko01000 Bacteria 1RCYU@1224,2K46C@204457,2U728@28211,COG0346@1,COG0346@2 NA|NA|NA E methylmalonyl-CoA epimerase HIMHAPGP_00415 1122137.AQXF01000004_gene1522 8e-40 170.6 Bacteria Bacteria COG1082@1,COG1082@2 NA|NA|NA G myo-inosose-2 dehydratase activity HIMHAPGP_00416 1502850.FG91_03018 3.4e-78 298.5 Sphingomonadales neuA 2.7.7.43 ko:K00983 ko00520,ko01100,map00520,map01100 R01117,R04215 RC00152 ko00000,ko00001,ko01000 Bacteria 1RE9P@1224,2KDSE@204457,2UAVV@28211,COG2755@1,COG2755@2 NA|NA|NA E GDSL-like Lipase/Acylhydrolase HIMHAPGP_00417 1502850.FG91_01884 1.7e-166 593.2 Sphingomonadales Bacteria 1MWKN@1224,2K1H6@204457,2TU3F@28211,COG1629@1,COG4771@2 NA|NA|NA P TonB-dependent receptor HIMHAPGP_00418 414684.RC1_0013 4e-242 844.0 Rhodospirillales aidB ko:K09456 ko00000 Bacteria 1MU20@1224,2JPAH@204441,2TQU2@28211,COG1960@1,COG1960@2 NA|NA|NA I Acyl-CoA dehydrogenase, C-terminal domain HIMHAPGP_00419 392499.Swit_3813 4.6e-24 117.5 Sphingomonadales Bacteria 1N9JF@1224,298YE@1,2K6ST@204457,2UHRA@28211,2ZW29@2 NA|NA|NA HIMHAPGP_00420 272943.RSP_3184 5.4e-140 504.2 Rhodobacter atoB 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 iJN746.PP_2215 Bacteria 1FCBN@1060,1MU5G@1224,2TQQ7@28211,COG0183@1,COG0183@2 NA|NA|NA I Thiolase, C-terminal domain HIMHAPGP_00421 1234595.C725_1425 5.7e-33 149.1 Alphaproteobacteria ko:K02035,ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 1P91R@1224,2TT6P@28211,COG4166@1,COG4166@2 NA|NA|NA E ABC-type oligopeptide transport system periplasmic component HIMHAPGP_00422 392499.Swit_3958 2e-127 462.2 Sphingomonadales 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUBE@1224,2K0XR@204457,2TR4W@28211,COG0031@1,COG0031@2 NA|NA|NA E Cysteine synthase HIMHAPGP_00425 1123267.JONN01000001_gene437 1.3e-17 96.3 Sphingomonadales mraZ GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0040007,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 ko:K03925 ko00000 Bacteria 1RC62@1224,2K3M2@204457,2U8RU@28211,COG2001@1,COG2001@2 NA|NA|NA K Belongs to the MraZ family HIMHAPGP_00426 745310.G432_05590 1.9e-90 339.3 Sphingomonadales rsmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 ko:K03438 ko00000,ko01000,ko03009 Bacteria 1MUT4@1224,2K178@204457,2TRQA@28211,COG0275@1,COG0275@2 NA|NA|NA J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA HIMHAPGP_00427 1545915.JROG01000007_gene3139 9.2e-08 63.9 Sphingomonadales Bacteria 1NEPB@1224,2AK00@1,2K6PN@204457,2UFQJ@28211,32PGE@2 NA|NA|NA HIMHAPGP_00428 1234595.C725_2426 2.2e-137 496.1 unclassified Alphaproteobacteria ftsI GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008144,GO:0008150,GO:0008658,GO:0008955,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0031224,GO:0031226,GO:0031406,GO:0032153,GO:0033218,GO:0033293,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:1901363,GO:1901681 3.4.16.4 ko:K03587,ko:K08384,ko:K08724,ko:K12552,ko:K12556 ko00550,ko01100,ko01501,map00550,map01100,map01501 ko00000,ko00001,ko01000,ko01011,ko03036 iSSON_1240.SSON_0092 Bacteria 1MUNY@1224,2TSHQ@28211,4BPUT@82117,COG0768@1,COG0768@2 NA|NA|NA M PFAM Penicillin binding protein transpeptidase domain HIMHAPGP_00429 1123269.NX02_00715 2.5e-171 608.6 Sphingomonadales murE 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 Bacteria 1MU6P@1224,2K12F@204457,2TVXI@28211,COG0769@1,COG0769@2 NA|NA|NA M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan HIMHAPGP_00430 1248916.ANFY01000007_gene2255 1.8e-126 459.5 Sphingomonadales murF 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 Bacteria 1QTSF@1224,2K1N2@204457,2TR0Q@28211,COG0770@1,COG0770@2 NA|NA|NA M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein HIMHAPGP_00432 1123240.ATVO01000004_gene959 3.7e-40 171.8 Sphingomonadales nnrU Bacteria 1RDF9@1224,2K2CX@204457,2U7NM@28211,COG4094@1,COG4094@2 NA|NA|NA S NnrU protein HIMHAPGP_00433 1123240.ATVO01000004_gene958 7.6e-69 267.3 Sphingomonadales Bacteria 1QWIS@1224,2K3KB@204457,2TSR3@28211,COG4221@1,COG4221@2 NA|NA|NA S KR domain HIMHAPGP_00434 1219035.NT2_10_01230 5.9e-42 178.3 Alphaproteobacteria Bacteria 1R5XR@1224,2VF1R@28211,COG2207@1,COG2207@2 NA|NA|NA K Arabinose-binding domain of AraC transcription regulator, N-term HIMHAPGP_00435 196367.JNFG01000002_gene2265 8.7e-115 420.6 Burkholderiaceae Bacteria 1K4I6@119060,1P7WH@1224,2VMPJ@28216,COG1960@1,COG1960@2 NA|NA|NA I Acyl-CoA dehydrogenase, C-terminal domain HIMHAPGP_00436 1415780.JPOG01000001_gene3152 3e-133 481.9 Xanthomonadales Bacteria 1MU8C@1224,1RNDU@1236,1XABV@135614,COG0183@1,COG0183@2 NA|NA|NA I Thiolase, C-terminal domain HIMHAPGP_00437 272943.RSP_2115 2.5e-132 478.4 Rhodobacter lpxC 3.5.1.108,4.2.1.59 ko:K02535,ko:K16363 ko00061,ko00540,ko01100,ko01212,map00061,map00540,map01100,map01212 M00060,M00083 R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965 RC00166,RC00300,RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004,ko01005 Bacteria 1FBAU@1060,1MV6T@1224,2TUHH@28211,COG0774@1,COG0774@2 NA|NA|NA M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis HIMHAPGP_00439 1248916.ANFY01000009_gene91 5.3e-179 634.4 Sphingomonadales recJ GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008297,GO:0008409,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0035312,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0045145,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 1MU1M@1224,2K0VW@204457,2TRZQ@28211,COG0608@1,COG0608@2 NA|NA|NA L single-stranded-DNA-specific exonuclease RecJ HIMHAPGP_00440 1081640.AGFU01000004_gene1590 6.5e-187 660.2 Sphingomonadales metY 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 Bacteria 1NQME@1224,2K1N7@204457,2TQW9@28211,COG2873@1,COG2873@2 NA|NA|NA E O-acetylhomoserine HIMHAPGP_00441 1030157.AFMP01000016_gene2435 1.4e-144 519.2 Sphingomonadales glpX 3.1.3.11,3.1.3.37 ko:K02446,ko:K11532 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00165,M00167 R00762,R01845,R04780 RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUB1@1224,2JZUH@204457,2TSPE@28211,COG1494@1,COG1494@2 NA|NA|NA G in Escherichia coli this protein forms a dimer and binds manganese HIMHAPGP_00442 1030157.AFMP01000016_gene2433 5.3e-160 570.9 Sphingomonadales hom GO:0003674,GO:0003824,GO:0004412,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1294,iSB619.SA_RS06610 Bacteria 1MUDC@1224,2K2BW@204457,2TQWS@28211,COG0460@1,COG0460@2 NA|NA|NA E homoserine dehydrogenase HIMHAPGP_00443 579138.Zymop_0800 4.6e-37 161.4 Sphingomonadales gcrA ko:K13583 ko04112,map04112 ko00000,ko00001 Bacteria 1RHI6@1224,2K0A1@204457,2TS7F@28211,COG5352@1,COG5352@2 NA|NA|NA S GcrA cell cycle regulator HIMHAPGP_00444 1234595.C725_1630 2e-88 332.4 unclassified Alphaproteobacteria yadH ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1MUH1@1224,2TQSY@28211,4BQ01@82117,COG0842@1,COG0842@2 NA|NA|NA V ABC-2 type transporter HIMHAPGP_00445 1123269.NX02_24155 2.4e-134 486.5 Sphingomonadales tamA ko:K07278 ko00000,ko02000 1.B.33.2.4 Bacteria 1MUKM@1224,2JZVN@204457,2TRWD@28211,COG0729@1,COG0729@2 NA|NA|NA M COG0729 Outer membrane protein HIMHAPGP_00446 46429.BV95_02920 1e-212 747.7 Sphingomonadales ko:K09800 ko00000,ko02000 Bacteria 1MUVD@1224,2K0C4@204457,2TR45@28211,COG2911@1,COG2911@2 NA|NA|NA S protein conserved in bacteria HIMHAPGP_00447 1123267.JONN01000001_gene1800 5.4e-13 80.9 Sphingomonadales Bacteria 1NG3X@1224,2BJB4@1,2K6GS@204457,2UG56@28211,3186Q@2 NA|NA|NA HIMHAPGP_00448 745310.G432_00530 7.9e-79 301.2 Sphingomonadales iaaH 3.5.1.86,6.3.5.6,6.3.5.7 ko:K02433,ko:K18541,ko:K21801 ko00380,ko00627,ko00970,ko01100,ko01120,map00380,map00627,map00970,map01100,map01120 R03905,R04212,R05783 RC00010,RC00358 ko00000,ko00001,ko01000,ko03029 Bacteria 1MUVQ@1224,2KCM0@204457,2TU3V@28211,COG0154@1,COG0154@2 NA|NA|NA J Amidase HIMHAPGP_00449 745310.G432_04180 1e-144 520.0 Sphingomonadales proA GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 iLJ478.TM0293,iYO844.BSU13130 Bacteria 1MUGJ@1224,2K0DR@204457,2TS83@28211,COG0014@1,COG0014@2 NA|NA|NA E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate HIMHAPGP_00450 158500.BV97_02054 1.5e-64 252.7 Sphingomonadales nadD 2.7.7.18,3.6.1.55 ko:K00969,ko:K03574 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 Bacteria 1RD0J@1224,2K3WB@204457,2U6ZC@28211,COG1057@1,COG1057@2 NA|NA|NA H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) HIMHAPGP_00451 383381.EH30_15265 3.5e-35 154.5 Sphingomonadales rsfS GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113 2.7.7.18 ko:K00969,ko:K09710 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000,ko03009 Bacteria 1MZEF@1224,2K55D@204457,2UBSV@28211,COG0799@1,COG0799@2 NA|NA|NA J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation HIMHAPGP_00452 1248760.ANFZ01000024_gene1694 1.5e-40 172.6 Sphingomonadales rlmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042802,GO:0042803,GO:0043021,GO:0043022,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0044877,GO:0046483,GO:0046983,GO:0070037,GO:0070038,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.177 ko:K00783 ko00000,ko01000,ko03009 Bacteria 1R9Z2@1224,2K4F0@204457,2U95Q@28211,COG1576@1,COG1576@2 NA|NA|NA J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA HIMHAPGP_00453 1030157.AFMP01000062_gene3501 2.7e-159 568.5 Sphingomonadales ctpA 3.4.21.102 ko:K03797 ko00000,ko01000,ko01002 Bacteria 1MU39@1224,2K0TK@204457,2TRW2@28211,COG0793@1,COG0793@2 NA|NA|NA M Belongs to the peptidase S41A family HIMHAPGP_00454 388739.RSK20926_19032 5.9e-37 160.6 Roseobacter dsbB ko:K03611 ko00000,ko03110 5.A.2.1 Bacteria 1N89I@1224,2P3CC@2433,2UF49@28211,COG1495@1,COG1495@2 NA|NA|NA C COG1495 Disulfide bond formation protein DsbB HIMHAPGP_00455 1234595.C725_1769 3.2e-55 221.5 Alphaproteobacteria coq7 ko:K06134 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00128 R04984,R08775 RC01254 ko00000,ko00001,ko00002,ko01000 Bacteria 1RAK4@1224,2U85I@28211,COG2941@1,COG2941@2 NA|NA|NA H Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol HIMHAPGP_00456 745310.G432_07140 6.9e-120 437.2 Sphingomonadales moaA 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 R09394 RC03420 ko00000,ko00001,ko01000 Bacteria 1MW3W@1224,2K041@204457,2TQQP@28211,COG2896@1,COG2896@2 NA|NA|NA H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate HIMHAPGP_00457 1123240.ATVO01000003_gene604 3.2e-85 321.6 Sphingomonadales nadK 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 R00104 RC00002,RC00078 ko00000,ko00001,ko01000 Bacteria 1MUBC@1224,2K0E6@204457,2TSKN@28211,COG0061@1,COG0061@2 NA|NA|NA G Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP HIMHAPGP_00458 1234595.C725_0906 4.6e-86 324.7 unclassified Alphaproteobacteria lipN ko:K01066 ko00000,ko01000 Bacteria 1NEXK@1224,2U5X1@28211,4BQU9@82117,COG0657@1,COG0657@2 NA|NA|NA I alpha/beta hydrolase fold HIMHAPGP_00459 1081640.AGFU01000032_gene2437 4.9e-50 204.1 Sphingomonadales nudH GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019222,GO:0019439,GO:0034353,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 ko:K08311 ko03018,map03018 R10816 RC00002 ko00000,ko00001,ko01000,ko03019 Bacteria 1QU0T@1224,2K4S3@204457,2TW25@28211,COG1051@1,COG1051@2 NA|NA|NA F Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage HIMHAPGP_00460 1205680.CAKO01000025_gene4616 1.3e-56 226.5 Rhodospirillales 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 Bacteria 1NKIB@1224,2JTNN@204441,2U933@28211,COG0412@1,COG0412@2 NA|NA|NA Q Dienelactone hydrolase family HIMHAPGP_00461 13689.BV96_01744 6e-61 240.4 Sphingomonadales MA20_20905 1.11.1.15 ko:K03386 ko04214,map04214 ko00000,ko00001,ko01000,ko04147 Bacteria 1MU0H@1224,2K3WE@204457,2U6ZN@28211,COG0678@1,COG0678@2 NA|NA|NA O Alkyl hydroperoxide reductase HIMHAPGP_00462 1030157.AFMP01000009_gene3676 2.6e-55 221.9 Sphingomonadales MA20_18155 ko:K07735 ko00000,ko03000 Bacteria 1RCXM@1224,2K3S2@204457,2TTX4@28211,COG1678@1,COG1678@2 NA|NA|NA K Belongs to the UPF0301 (AlgH) family HIMHAPGP_00463 1248916.ANFY01000011_gene1151 3.5e-256 891.0 Sphingomonadales pccA 6.4.1.3 ko:K01965 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 Bacteria 1P6RE@1224,2K050@204457,2TRC2@28211,COG4770@1,COG4770@2 NA|NA|NA I acetyl propionyl-CoA carboxylase, alpha subunit HIMHAPGP_00465 1123240.ATVO01000005_gene1790 1.7e-127 463.0 Sphingomonadales degS GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0009987,GO:0010033,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030163,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0033554,GO:0035966,GO:0035967,GO:0042221,GO:0042597,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051603,GO:0051716,GO:0051788,GO:0061077,GO:0070011,GO:0070887,GO:0071218,GO:0071310,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.21.107 ko:K04691,ko:K04771,ko:K04772 ko01503,ko02020,map01503,map02020 M00728 ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 Bacteria 1MU63@1224,2K08H@204457,2TQPZ@28211,COG0265@1,COG0265@2 NA|NA|NA M Belongs to the peptidase S1C family HIMHAPGP_00466 1123240.ATVO01000006_gene1437 9.8e-67 260.4 Sphingomonadales aat GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008914,GO:0016740,GO:0016746,GO:0016755,GO:0044424,GO:0044464,GO:0140096 2.3.2.6 ko:K00684 R03813,R11443,R11444 RC00055,RC00064 ko00000,ko01000 Bacteria 1R9W8@1224,2K180@204457,2U59K@28211,COG2360@1,COG2360@2 NA|NA|NA O Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine HIMHAPGP_00467 1479239.JQMU01000001_gene1016 9.4e-19 100.5 Sphingomonadales ko:K07465 ko00000 Bacteria 1MYCS@1224,2K5HJ@204457,2VDKV@28211,COG4765@1,COG4765@2 NA|NA|NA S protein conserved in bacteria HIMHAPGP_00469 1248916.ANFY01000005_gene2739 6.8e-77 293.9 Sphingomonadales phoU GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 ko:K02039 ko00000 Bacteria 1MUMI@1224,2K0AA@204457,2TQMN@28211,COG0704@1,COG0704@2 NA|NA|NA P Plays a role in the regulation of phosphate uptake HIMHAPGP_00470 745310.G432_01525 3e-121 441.4 Sphingomonadales pstB 3.6.3.27 ko:K02036 ko02010,map02010 M00222 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 Bacteria 1MU16@1224,2JZZN@204457,2TQX9@28211,COG1117@1,COG1117@2 NA|NA|NA P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system HIMHAPGP_00471 1248916.ANFY01000005_gene2737 4.6e-140 504.6 Sphingomonadales pstA ko:K02038 ko02010,map02010 M00222 ko00000,ko00001,ko00002,ko02000 3.A.1.7 Bacteria 1MUWB@1224,2JZYA@204457,2TQYQ@28211,COG0581@1,COG0581@2 NA|NA|NA P phosphate transport system permease HIMHAPGP_00472 1248916.ANFY01000005_gene2736 1.9e-144 519.2 Sphingomonadales pstC ko:K02037,ko:K02038 ko02010,map02010 M00222 ko00000,ko00001,ko00002,ko02000 3.A.1.7 Bacteria 1MVKP@1224,2K16C@204457,2TQU1@28211,COG0573@1,COG0573@2 NA|NA|NA P probably responsible for the translocation of the substrate across the membrane HIMHAPGP_00473 1123240.ATVO01000007_gene2226 3.2e-115 421.8 Sphingomonadales pstS ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 ko00000,ko00001,ko00002,ko02000 3.A.1.7 Bacteria 1MUH9@1224,2K0M7@204457,2TR1C@28211,COG0226@1,COG0226@2 NA|NA|NA P Phosphate ABC transporter substrate-binding protein HIMHAPGP_00474 1248916.ANFY01000005_gene2734 4.8e-94 351.7 Sphingomonadales phoR GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016021,GO:0016036,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031224,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0035556,GO:0036211,GO:0042578,GO:0042594,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071496,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.7.13.3 ko:K02484,ko:K07636 ko02020,map02020 M00434 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 1MWF3@1224,2K1ZG@204457,2TR46@28211,COG5002@1,COG5002@2 NA|NA|NA T Histidine kinase HIMHAPGP_00475 1248916.ANFY01000005_gene2794 5.7e-163 580.9 Sphingomonadales wcaJ ko:K03606,ko:K20997 ko02025,ko05111,map02025,map05111 ko00000,ko00001 Bacteria 1MV6W@1224,2K10K@204457,2TRZA@28211,COG2148@1,COG2148@2 NA|NA|NA M sugar transferase HIMHAPGP_00476 392499.Swit_2369 1.2e-20 105.5 Sphingomonadales Bacteria 1P2MK@1224,2AM6V@1,2K704@204457,2UV1F@28211,31C1G@2 NA|NA|NA HIMHAPGP_00477 1248916.ANFY01000005_gene2792 6.1e-54 217.6 Sphingomonadales Bacteria 1RCXC@1224,2DKYH@1,2K4QW@204457,2U6TU@28211,30WKQ@2 NA|NA|NA S Protein of unknown function (DUF3485) HIMHAPGP_00478 1248916.ANFY01000005_gene2791 5.2e-74 284.6 Alphaproteobacteria Bacteria 1MXZG@1224,2TUKE@28211,COG1269@1,COG1269@2 NA|NA|NA C transmembrane protein EpsH HIMHAPGP_00479 1248916.ANFY01000005_gene2790 3.1e-76 292.0 Sphingomonadales epsG 2.7.10.1 ko:K08252 ko00000,ko01000 Bacteria 1QAMW@1224,2K5H7@204457,2UBYS@28211,COG0489@1,COG0489@2 NA|NA|NA D AAA domain HIMHAPGP_00480 1248916.ANFY01000005_gene2789 3.4e-80 305.8 Sphingomonadales ko:K07011,ko:K16554 ko05111,map05111 ko00000,ko00001,ko02000 8.A.3.1 Bacteria 1QQCB@1224,2K2X1@204457,2U6JT@28211,COG3206@1,COG3206@2 NA|NA|NA M protein involved in exopolysaccharide biosynthesis HIMHAPGP_00481 1248916.ANFY01000005_gene2788 6e-61 241.1 Sphingomonadales epsE ko:K01991,ko:K20988 ko02026,ko05111,map02026,map05111 ko00000,ko00001,ko02000 1.B.18 Bacteria 1N2G0@1224,2K4N6@204457,2UECQ@28211,COG1596@1,COG1596@2 NA|NA|NA M Polysaccharide biosynthesis/export protein HIMHAPGP_00482 1081640.AGFU01000001_gene529 9.8e-24 118.2 Bacteria epsL Bacteria COG5338@1,COG5338@2 NA|NA|NA P Protein conserved in bacteria HIMHAPGP_00483 1248916.ANFY01000005_gene2786 2.7e-111 409.1 Sphingomonadales ko:K07491 ko00000 Bacteria 1RI2D@1224,2K5RH@204457,2U9M3@28211,COG1672@1,COG1672@2 NA|NA|NA S AAA domain HIMHAPGP_00484 1248916.ANFY01000005_gene2785 1e-75 290.4 Sphingomonadales Bacteria 1R5GW@1224,2K3YZ@204457,2TTEN@28211,COG1216@1,COG1216@2 NA|NA|NA S Glycosyltransferase like family 2 HIMHAPGP_00485 1248916.ANFY01000010_gene426 8.8e-118 431.0 Sphingomonadales MA20_25080 Bacteria 1MUJ4@1224,2K1RQ@204457,2TR5G@28211,COG5360@1,COG5360@2 NA|NA|NA S Heparinase HIMHAPGP_00486 1123267.JONN01000001_gene2197 9.9e-86 323.2 Sphingomonadales rpe GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUZM@1224,2K1ZB@204457,2TQKR@28211,COG0036@1,COG0036@2 NA|NA|NA G Belongs to the ribulose-phosphate 3-epimerase family HIMHAPGP_00487 190650.CC_1288 1.6e-35 156.4 Caulobacterales Bacteria 1N135@1224,2DN5Z@1,2KHBN@204458,2U9PS@28211,32VR7@2 NA|NA|NA S Protein of unknown function (DUF2490) HIMHAPGP_00488 1219049.SP5_076_00150 4.9e-10 71.6 Sphingomonadales Bacteria 1MYMI@1224,2BX8M@1,2K27Q@204457,2UB1B@28211,31H0R@2 NA|NA|NA S Protein of unknown function (DUF4230) HIMHAPGP_00489 1123240.ATVO01000006_gene1506 2.3e-102 379.0 Sphingomonadales MA20_07390 3.1.2.6 ko:K01069,ko:K07455 ko00620,map00620 R01736 RC00004,RC00137 ko00000,ko00001,ko01000,ko03400 Bacteria 1MVC3@1224,2K18T@204457,2TUAZ@28211,COG0491@1,COG0491@2 NA|NA|NA S COG0491 Zn-dependent hydrolases, including glyoxylases HIMHAPGP_00491 627192.SLG_13260 1.6e-56 225.3 Sphingomonadales purC GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016874,GO:0016879,GO:0016881,GO:0044424,GO:0044444,GO:0044464 4.1.1.21,4.3.2.2,6.3.2.6 ko:K01587,ko:K01756,ko:K01923 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04209,R04559,R04591 RC00064,RC00162,RC00379,RC00444,RC00445,RC00590 ko00000,ko00001,ko00002,ko01000 iAF1260.b2476,iB21_1397.B21_02330,iBWG_1329.BWG_2240,iE2348C_1286.E2348C_2713,iEC042_1314.EC042_2677,iEC55989_1330.EC55989_2759,iECABU_c1320.ECABU_c27880,iECBD_1354.ECBD_1213,iECB_1328.ECB_02368,iECDH10B_1368.ECDH10B_2642,iECDH1ME8569_1439.ECDH1ME8569_2402,iECDH1ME8569_1439.EcDH1_1193,iECD_1391.ECD_02368,iECED1_1282.ECED1_2911,iECH74115_1262.ECH74115_3698,iECIAI1_1343.ECIAI1_2527,iECNA114_1301.ECNA114_2561,iECO103_1326.ECO103_2988,iECO111_1330.ECO111_3199,iECO26_1355.ECO26_3522,iECOK1_1307.ECOK1_2784,iECP_1309.ECP_2490,iECS88_1305.ECS88_2658,iECSE_1348.ECSE_2760,iECSF_1327.ECSF_2329,iECSP_1301.ECSP_3415,iECUMN_1333.ECUMN_2789,iECW_1372.ECW_m2698,iECs_1301.ECs3338,iEKO11_1354.EKO11_1259,iETEC_1333.ETEC_2581,iEcDH1_1363.EcDH1_1193,iEcE24377_1341.EcE24377A_2757,iEcHS_1320.EcHS_A2607,iEcSMS35_1347.EcSMS35_2623,iEcolC_1368.EcolC_1200,iG2583_1286.G2583_2999,iJN746.PP_1240,iJO1366.b2476,iJR904.b2476,iLF82_1304.LF82_1775,iNRG857_1313.NRG857_12360,iSFV_1184.SFV_2521,iSF_1195.SF2519,iSFxv_1172.SFxv_2773,iS_1188.S2669,iSbBS512_1146.SbBS512_E2848,iUMNK88_1353.UMNK88_3071,iWFL_1372.ECW_m2698,iY75_1357.Y75_RS12925,iYL1228.KPN_02810,iZ_1308.Z3735 Bacteria 1MUR9@1224,2K0D0@204457,2TR8D@28211,COG0152@1,COG0152@2 NA|NA|NA F Belongs to the SAICAR synthetase family HIMHAPGP_00492 760117.JN27_20325 2.9e-54 219.2 Oxalobacteraceae Bacteria 1RGPG@1224,2WBGW@28216,475SP@75682,COG0657@1,COG0657@2 NA|NA|NA I alpha/beta hydrolase fold HIMHAPGP_00493 1030157.AFMP01000008_gene3252 1.8e-28 132.1 Sphingomonadales yigI Bacteria 1RITB@1224,2K6CX@204457,2U58S@28211,COG2050@1,COG2050@2 NA|NA|NA Q protein, possibly involved in aromatic compounds catabolism HIMHAPGP_00494 1550073.JROH01000001_gene646 2.1e-36 158.7 Sphingomonadales MA20_04725 ko:K02614 ko00360,map00360 R09840 RC00004,RC00014 ko00000,ko00001,ko01000 Bacteria 1RHK6@1224,2K530@204457,2U72Z@28211,COG2050@1,COG2050@2 NA|NA|NA Q protein, possibly involved in aromatic compounds catabolism HIMHAPGP_00495 13689.BV96_02223 2.4e-34 151.8 Sphingomonadales sufE ko:K02426 ko00000 Bacteria 1RI8F@1224,2K4H9@204457,2U9A2@28211,COG2166@1,COG2166@2 NA|NA|NA S SufE protein probably involved in Fe-S center assembly HIMHAPGP_00496 1123240.ATVO01000008_gene2385 5e-10 70.5 Alphaproteobacteria Bacteria 1NK1C@1224,2DNTE@1,2UJRY@28211,32Z25@2 NA|NA|NA HIMHAPGP_00497 1090318.ATTI01000001_gene1998 1.7e-08 65.1 Sphingomonadales Bacteria 1NQ2N@1224,2DNTE@1,2K6S0@204457,2UM3U@28211,32Z25@2 NA|NA|NA HIMHAPGP_00498 627192.SLG_36150 2.5e-33 148.3 Sphingomonadales pspC ko:K03973 ko00000,ko02048,ko03000 Bacteria 1N0KE@1224,2KCG9@204457,2UCKP@28211,COG1983@1,COG1983@2 NA|NA|NA KT phage shock protein C HIMHAPGP_00499 1123269.NX02_13195 5.6e-20 103.6 Sphingomonadales pspB ko:K03970 ko00000,ko02048 Bacteria 1N7AP@1224,2EH78@1,2K6SQ@204457,2UGJI@28211,33AZ2@2 NA|NA|NA S Phage shock protein B HIMHAPGP_00500 392499.Swit_2937 3.4e-70 271.6 Sphingomonadales pspA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 ko:K03969 ko00000 Bacteria 1NC7S@1224,2K2DP@204457,2U6CN@28211,COG1842@1,COG1842@2 NA|NA|NA KT Phage shock protein A HIMHAPGP_00501 1122612.AUBA01000009_gene2032 5.3e-123 447.6 Sphingomonadales pspF ko:K03974,ko:K15836 ko00000,ko03000 Bacteria 1QUPP@1224,2K0CK@204457,2TR58@28211,COG3829@1,COG3829@2 NA|NA|NA K Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain HIMHAPGP_00502 1248916.ANFY01000010_gene365 2.6e-54 218.8 Sphingomonadales tlyC ko:K06189 ko00000,ko02000 9.A.40.1.2 Bacteria 1MV3P@1224,2K03F@204457,2TVFA@28211,COG1253@1,COG1253@2 NA|NA|NA S COG1253 Hemolysins and related proteins containing CBS domains HIMHAPGP_00504 1030157.AFMP01000004_gene2070 8.7e-66 257.3 Sphingomonadales Bacteria 1RKX7@1224,2K4KU@204457,2UB2T@28211,COG2207@1,COG2207@2 NA|NA|NA K Helix-turn-helix domain HIMHAPGP_00505 1174684.EBMC1_03020 6.1e-145 521.2 Sphingomonadales phoD 3.1.3.1 ko:K01113,ko:K07004 ko00790,ko01100,ko02020,map00790,map01100,map02020 M00126 R04620 RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 1MWAF@1224,2K06C@204457,2U0FQ@28211,COG3540@1,COG3540@2 NA|NA|NA P Alkaline phosphatase HIMHAPGP_00507 1470591.BW41_00784 1.5e-228 799.3 Sphingomonadales spoT GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 iECNA114_1301.ECNA114_3794,iECOK1_1307.ECOK1_4092,iECP_1309.ECP_3748,iECS88_1305.ECS88_4065,iECSF_1327.ECSF_3486,iLF82_1304.LF82_2165,iNRG857_1313.NRG857_18145,iUMN146_1321.UM146_18405,iUTI89_1310.UTI89_C4195,ic_1306.c4475 Bacteria 1MU44@1224,2K15Q@204457,2TQNY@28211,COG0317@1,COG0317@2 NA|NA|NA KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance HIMHAPGP_00508 1248916.ANFY01000007_gene2415 1.5e-93 349.0 Sphingomonadales rpsD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 ko:K02986 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1MW0U@1224,2K0KZ@204457,2TRQH@28211,COG0522@1,COG0522@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit HIMHAPGP_00509 1123269.NX02_25095 1.4e-43 182.2 Sphingomonadales rpoZ GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944 2.7.7.6 ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 Bacteria 1N6TX@1224,2K5I6@204457,2U9BQ@28211,COG1758@1,COG1758@2 NA|NA|NA K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits HIMHAPGP_00511 371731.Rsw2DRAFT_2407 7.2e-12 77.4 Rhodobacter Bacteria 1FD05@1060,1QYCC@1224,2VBHZ@28211,COG5339@1,COG5339@2 NA|NA|NA S Putative bacterial sensory transduction regulator HIMHAPGP_00512 1234595.C725_0298 2.1e-28 132.1 Alphaproteobacteria holC GO:0005575,GO:0005622,GO:0005623,GO:0006275,GO:0008150,GO:0009314,GO:0009360,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010556,GO:0010557,GO:0010604,GO:0019219,GO:0019222,GO:0030174,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032298,GO:0032991,GO:0042575,GO:0043846,GO:0043847,GO:0044424,GO:0044464,GO:0045740,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051171,GO:0051173,GO:0060255,GO:0061695,GO:0065007,GO:0080090,GO:0090329,GO:1902494,GO:1990234,GO:2000105,GO:2000112 2.7.7.7 ko:K02339 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 1RGVC@1224,2U94V@28211,COG2927@1,COG2927@2 NA|NA|NA L DNA polymerase III, chi subunit HIMHAPGP_00513 1248916.ANFY01000009_gene249 2.2e-154 552.4 Sphingomonadales pepA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.4.11.1,3.4.11.5 ko:K01255,ko:K01259 ko00330,ko00480,ko01100,map00330,map00480,map01100 R00135,R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 Bacteria 1MUF9@1224,2K04B@204457,2TQU9@28211,COG0260@1,COG0260@2 NA|NA|NA E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides HIMHAPGP_00514 1030157.AFMP01000017_gene1218 2.2e-52 212.6 Sphingomonadales ygfZ GO:0003674,GO:0005488,GO:0005542,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0019842,GO:0022607,GO:0031163,GO:0031406,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0071840,GO:0072341,GO:0097159,GO:1901363 ko:K06980 ko00000,ko03016 Bacteria 1N852@1224,2K18B@204457,2TR8J@28211,COG0354@1,COG0354@2 NA|NA|NA S Aminomethyltransferase HIMHAPGP_00515 1123240.ATVO01000003_gene162 1.2e-67 263.5 Sphingomonadales citE 3.1.2.30,4.1.3.25,4.1.3.34 ko:K01644,ko:K14451,ko:K18292 ko00630,ko00660,ko01100,ko01120,ko01200,ko02020,map00630,map00660,map01100,map01120,map01200,map02020 M00373 R00237,R00362,R10612 RC00004,RC00014,RC00067,RC00502,RC01118,RC01205 ko00000,ko00001,ko00002,ko01000 Bacteria 1MW0A@1224,2K2U8@204457,2TTC0@28211,COG2301@1,COG2301@2 NA|NA|NA G Belongs to the HpcH HpaI aldolase family HIMHAPGP_00516 685778.AORL01000010_gene2954 9.5e-100 369.8 Sphingomonadales rplA GO:0000027,GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006417,GO:0006446,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0017148,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045947,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 ko:K02863 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1MUE6@1224,2K0YM@204457,2TRXP@28211,COG0081@1,COG0081@2 NA|NA|NA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release HIMHAPGP_00517 234267.Acid_5806 8.5e-59 233.8 Acidobacteria cah 4.2.1.1 ko:K01673 ko00910,map00910 R00132,R10092 RC02807 ko00000,ko00001,ko01000 Bacteria 3Y5CY@57723,COG0288@1,COG0288@2 NA|NA|NA H Reversible hydration of carbon dioxide HIMHAPGP_00518 1248916.ANFY01000003_gene671 1.1e-55 223.0 Sphingomonadales rplJ GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0017148,GO:0019222,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 ko:K02864,ko:K02935 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1RAN5@1224,2K3XB@204457,2U592@28211,COG0244@1,COG0244@2 NA|NA|NA J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors HIMHAPGP_00519 194867.ALBQ01000034_gene1027 5.7e-43 180.3 Sphingomonadales rplL ko:K02935 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1RGU4@1224,2K4H8@204457,2U9FX@28211,COG0222@1,COG0222@2 NA|NA|NA J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation HIMHAPGP_00520 13689.BV96_04674 8.7e-49 200.3 Sphingomonadales ko:K16079 ko00000,ko02000 1.B.4.2.1 Bacteria 1NJWW@1224,2K4HB@204457,2UD8G@28211,COG3637@1,COG3637@2 NA|NA|NA M Outer membrane protein beta-barrel domain HIMHAPGP_00521 1174684.EBMC1_13868 9.6e-92 343.6 Sphingomonadales Bacteria 1N2XW@1224,2K1P0@204457,2U0CF@28211,COG0657@1,COG0657@2 NA|NA|NA I alpha/beta hydrolase fold HIMHAPGP_00523 1545915.JROG01000004_gene1692 6.2e-39 166.8 Sphingomonadales rplT GO:0000027,GO:0000900,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0060255,GO:0065003,GO:0065007,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090079,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2000113,GO:2001141 ko:K02887 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1RGU2@1224,2K4FX@204457,2U756@28211,COG0292@1,COG0292@2 NA|NA|NA J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit HIMHAPGP_00524 1123267.JONN01000001_gene2106 1.4e-27 128.3 Sphingomonadales rpmI GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 ko:K02916 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1N6V4@1224,2K5YR@204457,2UF6K@28211,COG0291@1,COG0291@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL35 family HIMHAPGP_00525 685778.AORL01000019_gene1788 5.6e-41 173.7 Sphingomonadales clpS GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0050896,GO:0051087 ko:K06891 ko00000 Bacteria 1MZU8@1224,2K5BT@204457,2U982@28211,COG2127@1,COG2127@2 NA|NA|NA S Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation HIMHAPGP_00526 1331060.RLDS_16290 7.3e-78 297.7 Sphingomonadales ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 Bacteria 1MUFW@1224,2KDTV@204457,2U2CU@28211,COG0845@1,COG0845@2 NA|NA|NA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family HIMHAPGP_00527 1030157.AFMP01000050_gene61 0.0 1206.4 Sphingomonadales acrB ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 Bacteria 1MU48@1224,2K02H@204457,2TQT0@28211,COG0841@1,COG0841@2 NA|NA|NA V Efflux pump membrane transporter HIMHAPGP_00528 1123269.NX02_09065 1e-16 92.8 Sphingomonadales yqiC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 ko:K09806 ko00000 Bacteria 1N725@1224,2K74V@204457,2UFEP@28211,COG2960@1,COG2960@2 NA|NA|NA S Membrane fusogenic activity HIMHAPGP_00529 1007104.SUS17_1199 1.1e-55 223.0 Sphingomonadales MA20_05485 Bacteria 1REC1@1224,2K1T3@204457,2U7UP@28211,COG5465@1,COG5465@2 NA|NA|NA S Putative bacterial sensory transduction regulator HIMHAPGP_00531 1123240.ATVO01000003_gene446 3.1e-53 215.3 Sphingomonadales 3.5.1.68 ko:K01458 ko00340,ko00630,map00340,map00630 R00525 RC00165,RC00323 ko00000,ko00001,ko01000 Bacteria 1QI71@1224,2K3BC@204457,2TVK6@28211,COG3931@1,COG3931@2 NA|NA|NA E N-formylglutamate amidohydrolase HIMHAPGP_00532 1123240.ATVO01000006_gene1337 4.9e-69 267.7 Sphingomonadales mtgA GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008955,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0030203,GO:0034645,GO:0042546,GO:0043164,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.4.1.129,3.4.16.4 ko:K03814,ko:K05365 ko00550,map00550 R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 GT51 Bacteria 1RDAQ@1224,2K0ZN@204457,2U0NP@28211,COG0744@1,COG0744@2 NA|NA|NA M Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors HIMHAPGP_00533 1333998.M2A_1986 1.5e-72 279.6 Alphaproteobacteria Bacteria 1MUPX@1224,2TT6C@28211,COG1028@1,COG1028@2 NA|NA|NA IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) HIMHAPGP_00534 1502850.FG91_03017 7.6e-26 123.2 Sphingomonadales Bacteria 1N8UC@1224,2KDB8@204457,2U3J4@28211,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family HIMHAPGP_00535 1502850.FG91_03016 1.4e-301 1042.0 Sphingomonadales bglB 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 GH3 Bacteria 1MVIV@1224,2JZVY@204457,2TS28@28211,COG1472@1,COG1472@2 NA|NA|NA G Belongs to the glycosyl hydrolase 3 family HIMHAPGP_00536 1449049.JONW01000007_gene4065 8.7e-14 83.2 Caulobacterales Bacteria 1N74W@1224,2EK15@1,2KHE1@204458,2UFQQ@28211,33DRN@2 NA|NA|NA HIMHAPGP_00537 1502850.FG91_03014 5.1e-226 790.8 Sphingomonadales 3.2.1.52 ko:K12373 ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142 M00079 R00022,R06004,R11316 RC00049 ko00000,ko00001,ko00002,ko01000,ko03110 GH20 Bacteria 1MVDE@1224,2K1S6@204457,2TSK6@28211,COG3525@1,COG3525@2 NA|NA|NA G Glycosyl hydrolase family 20, catalytic domain HIMHAPGP_00538 1502850.FG91_03013 4e-176 624.4 Sphingomonadales bglA 3.2.1.21 ko:K05350 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 Bacteria 1MWG6@1224,2K1C4@204457,2TSRN@28211,COG2723@1,COG2723@2 NA|NA|NA G Belongs to the glycosyl hydrolase 1 family HIMHAPGP_00539 1144307.PMI04_01791 1.6e-60 239.6 Sphingomonadales phoC 3.1.3.2 ko:K09474 ko00740,ko01100,ko02020,map00740,map01100,map02020 R00548 RC00017 ko00000,ko00001,ko01000 Bacteria 1PM2D@1224,2KDY3@204457,2VEZ3@28211,COG0671@1,COG0671@2 NA|NA|NA I Acid phosphatase HIMHAPGP_00540 745310.G432_12020 1.2e-128 466.5 Sphingomonadales MA20_36195 ko:K09919 ko00000 Bacteria 1MU35@1224,2K1NQ@204457,2TS5I@28211,COG3146@1,COG3146@2 NA|NA|NA S protein conserved in bacteria HIMHAPGP_00541 392499.Swit_2784 1.5e-48 199.1 Sphingomonadales Bacteria 1RHMZ@1224,2K4U7@204457,2U9H4@28211,COG0251@1,COG0251@2 NA|NA|NA J endoribonuclease HIMHAPGP_00542 1234595.C725_2254 9.7e-48 196.8 Alphaproteobacteria Bacteria 1RCBD@1224,2U6UQ@28211,COG0647@1,COG0647@2 NA|NA|NA G UMP catabolic process HIMHAPGP_00543 13689.BV96_01221 8.2e-08 62.8 Sphingomonadales MA20_36230 Bacteria 1NH3D@1224,2DMKE@1,2K72S@204457,2UHAS@28211,32S6E@2 NA|NA|NA S Protein of unknown function (DUF3572) HIMHAPGP_00544 1248916.ANFY01000003_gene794 1.1e-91 343.2 Sphingomonadales pnp GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 Bacteria 1MVB9@1224,2K0IJ@204457,2TRH3@28211,COG1185@1,COG1185@2 NA|NA|NA J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction HIMHAPGP_00545 1248760.ANFZ01000004_gene1918 6.6e-71 274.2 Sphingomonadales MA20_37085 Bacteria 1PPKI@1224,2K0RA@204457,2TRIB@28211,COG0500@1,COG2226@2 NA|NA|NA Q Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) HIMHAPGP_00546 1163398.AJJP01000017_gene4001 1.1e-56 226.1 Gammaproteobacteria ybaO ko:K05800 ko00000,ko03000 Bacteria 1RFT6@1224,1S6RJ@1236,COG1522@1,COG1522@2 NA|NA|NA K Transcriptional regulator HIMHAPGP_00548 1123240.ATVO01000006_gene1613 9.3e-121 439.9 Sphingomonadales Bacteria 1QTAP@1224,2K0IC@204457,2TU8W@28211,COG2267@1,COG2267@2 NA|NA|NA I Alpha beta hydrolase HIMHAPGP_00549 1082933.MEA186_11746 1.7e-50 206.8 Phyllobacteriaceae Bacteria 1N2Z2@1224,2U7WI@28211,43JZD@69277,COG1835@1,COG1835@2 NA|NA|NA I Acyltransferase family HIMHAPGP_00550 392499.Swit_2438 5.1e-141 507.3 Sphingomonadales prs GO:0000287,GO:0003674,GO:0003824,GO:0004749,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006015,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016772,GO:0016778,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042301,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046391,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 iAF1260.b1207,iAPECO1_1312.APECO1_323,iB21_1397.B21_01192,iBWG_1329.BWG_1032,iE2348C_1286.E2348C_1330,iEC042_1314.EC042_1264,iEC55989_1330.EC55989_1303,iECABU_c1320.ECABU_c14780,iECBD_1354.ECBD_2414,iECB_1328.ECB_01182,iECDH10B_1368.ECDH10B_1260,iECDH1ME8569_1439.ECDH1ME8569_1146,iECD_1391.ECD_01182,iECED1_1282.ECED1_1355,iECH74115_1262.ECH74115_1688,iECIAI1_1343.ECIAI1_1228,iECIAI39_1322.ECIAI39_1543,iECNA114_1301.ECNA114_1372,iECO103_1326.ECO103_1309,iECO111_1330.ECO111_1536,iECO26_1355.ECO26_1720,iECOK1_1307.ECOK1_1360,iECP_1309.ECP_1255,iECS88_1305.ECS88_1275,iECSE_1348.ECSE_1257,iECSF_1327.ECSF_1183,iECSP_1301.ECSP_1597,iECUMN_1333.ECUMN_1504,iECW_1372.ECW_m1293,iECs_1301.ECs1712,iEKO11_1354.EKO11_2647,iETEC_1333.ETEC_1311,iEcDH1_1363.EcDH1_2440,iEcE24377_1341.EcE24377A_1355,iEcHS_1320.EcHS_A1312,iEcSMS35_1347.EcSMS35_1935,iEcolC_1368.EcolC_2419,iG2583_1286.G2583_1478,iJO1366.b1207,iJR904.b1207,iLF82_1304.LF82_1744,iLJ478.TM1628,iNRG857_1313.NRG857_06180,iSBO_1134.SBO_1860,iSDY_1059.SDY_1256,iSSON_1240.SSON_1971,iUMN146_1321.UM146_11025,iUMNK88_1353.UMNK88_1523,iUTI89_1310.UTI89_C1401,iWFL_1372.ECW_m1293,iY75_1357.Y75_RS06300,ic_1306.c1665 Bacteria 1MW21@1224,2K0MQ@204457,2TR4Y@28211,COG0462@1,COG0462@2 NA|NA|NA F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) HIMHAPGP_00551 1042377.AFPJ01000055_gene967 1.2e-29 137.1 Gammaproteobacteria 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 R00578 RC00010 ko00000,ko00001,ko01000,ko01002 Bacteria 1NDEB@1224,1SDZJ@1236,COG0367@1,COG0367@2 NA|NA|NA E asparagine synthase HIMHAPGP_00552 1057002.KB905370_gene5020 1.7e-45 190.7 Rhizobiaceae Bacteria 1MWJ6@1224,2U11C@28211,4BCQR@82115,COG0318@1,COG0318@2,COG1835@1,COG1835@2 NA|NA|NA IQ AMP-binding enzyme HIMHAPGP_00553 1248916.ANFY01000009_gene210 5.6e-110 404.8 Sphingomonadales ko:K08309 ko00000,ko01000,ko01011 GH23 Bacteria 1MV3F@1224,2K136@204457,2U35U@28211,COG0741@1,COG0741@2 NA|NA|NA M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) HIMHAPGP_00554 745310.G432_16005 3.1e-71 274.6 Sphingomonadales moaB GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0042802,GO:0044424,GO:0044444,GO:0044464 2.7.7.75 ko:K03638 ko00790,ko01100,map00790,map01100 R09726 RC00002 ko00000,ko00001,ko01000 Bacteria 1R9W2@1224,2K0DJ@204457,2TTA8@28211,COG0521@1,COG0521@2 NA|NA|NA H May be involved in the biosynthesis of molybdopterin HIMHAPGP_00555 1550073.JROH01000093_gene1428 2.5e-19 101.7 Sphingomonadales Bacteria 1NB42@1224,2CEYP@1,2K7BA@204457,2UHFF@28211,346DY@2 NA|NA|NA HIMHAPGP_00556 1449351.RISW2_09095 2.8e-68 265.8 Roseivivax corA GO:0000041,GO:0003674,GO:0005215,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0008150,GO:0008324,GO:0015075,GO:0015087,GO:0015095,GO:0015099,GO:0015318,GO:0015675,GO:0015693,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035444,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:1903830 ko:K03284 ko00000,ko02000 1.A.35.1,1.A.35.3 iAF987.Gmet_0134,iYL1228.KPN_04313 Bacteria 1MWMP@1224,2TQQD@28211,4KM04@93682,COG0598@1,COG0598@2 NA|NA|NA U CorA-like Mg2+ transporter protein HIMHAPGP_00558 378806.STAUR_0826 1.1e-125 456.8 Myxococcales 3.4.21.26 ko:K01322 ko04614,map04614 ko00000,ko00001,ko01000,ko01002 Bacteria 1NZ7N@1224,2WMMK@28221,2YU26@29,42NR5@68525,COG1505@1,COG1505@2 NA|NA|NA E Prolyl oligopeptidase, N-terminal beta-propeller domain HIMHAPGP_00559 1123240.ATVO01000006_gene1504 2e-99 369.0 Sphingomonadales nadC GO:0003674,GO:0003824,GO:0004514,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016020,GO:0016054,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0030312,GO:0034213,GO:0034641,GO:0034654,GO:0042737,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0072526,GO:0090407,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 1.4.3.16,2.4.2.19 ko:K00278,ko:K00767 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481,R03348 RC00006,RC02566,RC02877 ko00000,ko00001,ko00002,ko01000 Bacteria 1MW0C@1224,2K19F@204457,2TS7C@28211,COG0157@1,COG0157@2 NA|NA|NA H Belongs to the NadC ModD family HIMHAPGP_00560 633149.Bresu_1181 3.8e-42 178.3 Alphaproteobacteria Bacteria 1RF1C@1224,2U86S@28211,COG0500@1,COG2226@2 NA|NA|NA Q Methyltransferase domain HIMHAPGP_00561 1030157.AFMP01000031_gene2866 5.7e-13 79.3 Sphingomonadales dnaA GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 ko:K02313 ko02020,ko04112,map02020,map04112 ko00000,ko00001,ko03032,ko03036 Bacteria 1MU5H@1224,2JZZ0@204457,2TT03@28211,COG0593@1,COG0593@2 NA|NA|NA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids HIMHAPGP_00562 1248916.ANFY01000007_gene2461 4.1e-193 681.4 Sphingomonadales priA GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006276,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0010332,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042221,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0046677,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 ko:K04066 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 1MUUZ@1224,2K0DV@204457,2TQTQ@28211,COG1198@1,COG1198@2 NA|NA|NA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA HIMHAPGP_00563 392499.Swit_0850 8e-33 147.1 Sphingomonadales ligT 3.1.4.58 ko:K01975 ko00000,ko01000,ko03016 Bacteria 1RDB2@1224,2K3F8@204457,2U7FV@28211,COG1514@1,COG1514@2 NA|NA|NA J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester HIMHAPGP_00564 745310.G432_13200 1.7e-58 232.6 Sphingomonadales tesA GO:0003674,GO:0003824,GO:0004620,GO:0004622,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016289,GO:0016290,GO:0016298,GO:0016787,GO:0016788,GO:0016790,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0047617,GO:0052689,GO:0071704,GO:0140096,GO:1901564 3.1.1.5 ko:K10804 ko01040,map01040 ko00000,ko00001,ko01000,ko01004 iECED1_1282.ECED1_0521,iLF82_1304.LF82_2242,iNRG857_1313.NRG857_02365 Bacteria 1RCXZ@1224,2K1U9@204457,2U74E@28211,COG2755@1,COG2755@2 NA|NA|NA E COG2755 Lysophospholipase L1 and related esterases HIMHAPGP_00565 1123240.ATVO01000005_gene1761 9e-82 310.1 Sphingomonadales ybbA GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 ko:K02003 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 1MXG9@1224,2JZZV@204457,2TS0J@28211,COG4181@1,COG4181@2 NA|NA|NA Q ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component HIMHAPGP_00566 1030157.AFMP01000050_gene19 3e-196 692.2 Sphingomonadales MA20_43810 ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 1MU9R@1224,2K03T@204457,2TS8V@28211,COG3127@1,COG3127@2 NA|NA|NA Q ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component HIMHAPGP_00567 555793.WSK_1674 2.2e-68 265.8 Sphingomonadales ybhL GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K06890 ko00000 Bacteria 1MU69@1224,2K14K@204457,2TRSF@28211,COG0670@1,COG0670@2 NA|NA|NA S Belongs to the BI1 family HIMHAPGP_00568 1030157.AFMP01000059_gene2792 4.1e-57 227.6 Sphingomonadales gpo 1.11.1.22,1.11.1.9 ko:K00432,ko:K20207 ko00480,ko00590,ko04918,map00480,map00590,map04918 R00274,R07034,R07035 RC00011,RC00982 ko00000,ko00001,ko01000 iJN678.slr1171 Bacteria 1RD1R@1224,2K47B@204457,2U7R3@28211,COG0386@1,COG0386@2 NA|NA|NA O Belongs to the glutathione peroxidase family HIMHAPGP_00569 1382303.JPOM01000001_gene2082 5.3e-57 227.6 Caulobacterales cmk GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0015939,GO:0015940,GO:0015949,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 1.17.7.4,2.5.1.19,2.7.1.26,2.7.4.25,2.7.7.2,6.3.2.1 ko:K00800,ko:K00945,ko:K02945,ko:K03527,ko:K03977,ko:K11753,ko:K13799 ko00240,ko00400,ko00410,ko00740,ko00770,ko00900,ko01100,ko01110,ko01130,ko01230,ko03010,map00240,map00400,map00410,map00740,map00770,map00900,map01100,map01110,map01130,map01230,map03010 M00022,M00052,M00096,M00119,M00125,M00178 R00158,R00161,R00512,R00549,R01665,R02473,R03460,R05884,R08210 RC00002,RC00017,RC00096,RC00141,RC00350,RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko03009,ko03011 iPC815.YPO1391,iSDY_1059.SDY_2348 Bacteria 1MUUD@1224,2KGEG@204458,2U71H@28211,COG0283@1,COG0283@2 NA|NA|NA F Belongs to the cytidylate kinase family. Type 1 subfamily HIMHAPGP_00570 388399.SSE37_21295 7.1e-60 238.0 Alphaproteobacteria Bacteria 1P45H@1224,2A6N6@1,2UWRM@28211,30VG0@2 NA|NA|NA HIMHAPGP_00571 745310.G432_02200 8.9e-182 643.3 Sphingomonadales Bacteria 1MXXR@1224,2K1BD@204457,2TUMS@28211,COG1228@1,COG1228@2 NA|NA|NA Q amidohydrolase HIMHAPGP_00572 392499.Swit_0078 1.2e-199 703.0 Sphingomonadales ko:K03305 ko00000 2.A.17 Bacteria 1MW6W@1224,2K05X@204457,2U15C@28211,COG3104@1,COG3104@2 NA|NA|NA E amino acid peptide transporter HIMHAPGP_00573 1030157.AFMP01000031_gene2860 7.6e-142 510.4 Sphingomonadales coaBC GO:0000166,GO:0003674,GO:0003824,GO:0004632,GO:0004633,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0010181,GO:0015936,GO:0015937,GO:0016829,GO:0016830,GO:0016831,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032553,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.1.1.36,6.3.2.5 ko:K01598,ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 iEC042_1314.EC042_3945,iECUMN_1333.ECUMN_4154,iJN746.PP_5285,iSBO_1134.SBO_3641 Bacteria 1MVQP@1224,2K0N6@204457,2TRN1@28211,COG0452@1,COG0452@2 NA|NA|NA H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine HIMHAPGP_00574 1234595.C725_1026 7.2e-66 256.9 unclassified Alphaproteobacteria regA GO:0000156,GO:0000160,GO:0003674,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0023052,GO:0035556,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007 ko:K15012 ko02020,map02020 M00523 ko00000,ko00001,ko00002,ko02022 Bacteria 1RD7J@1224,2TSK7@28211,4BQ0D@82117,COG4567@1,COG4567@2 NA|NA|NA T PFAM Response regulator receiver domain HIMHAPGP_00575 1123240.ATVO01000009_gene839 1.6e-106 393.3 Sphingomonadales regB 2.7.13.3 ko:K07717,ko:K15011 ko02020,map02020 M00518,M00523 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 1QU3Y@1224,2KEUV@204457,2TVYH@28211,COG0642@1,COG0642@2 NA|NA|NA T His Kinase A (phosphoacceptor) domain HIMHAPGP_00576 1123240.ATVO01000009_gene838 3.8e-33 148.3 Sphingomonadales Bacteria 1RFFD@1224,2K4S6@204457,2U8T6@28211,COG0666@1,COG0666@2 NA|NA|NA S Ankyrin repeat HIMHAPGP_00577 1248916.ANFY01000010_gene401 7.8e-45 187.2 Sphingomonadales senC GO:0003674,GO:0005048,GO:0005488,GO:0033218,GO:0042277 ko:K03619,ko:K07152 ko00000,ko03029 Bacteria 1RHJ8@1224,2K4RS@204457,2U0Q3@28211,COG1999@1,COG1999@2 NA|NA|NA S protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems HIMHAPGP_00578 745310.G432_10275 7.7e-55 219.9 Sphingomonadales MA20_15575 ko:K09160 ko00000 Bacteria 1RHMX@1224,2K4JE@204457,2U99S@28211,COG2983@1,COG2983@2 NA|NA|NA S Belongs to the UPF0260 family HIMHAPGP_00579 1120705.FG95_03019 4.8e-22 110.9 Sphingomonadales Bacteria 1P8ZE@1224,2BA6T@1,2KC4I@204457,2UW84@28211,323KT@2 NA|NA|NA HIMHAPGP_00580 1245469.S58_10560 5.7e-49 200.3 Bradyrhizobiaceae Bacteria 1N023@1224,2UC7M@28211,3JZ34@41294,COG3791@1,COG3791@2 NA|NA|NA S Glutathione-dependent formaldehyde-activating enzyme HIMHAPGP_00581 1030157.AFMP01000044_gene1852 7.2e-76 290.4 Sphingomonadales trmB GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0040007,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.297,2.1.1.33,2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02493,ko:K02527,ko:K03439 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763,R10806 RC00003,RC00009,RC00077,RC00247,RC03279 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005,ko03012,ko03016 GT30 Bacteria 1MUWJ@1224,2K0BM@204457,2TUU9@28211,COG0220@1,COG0220@2 NA|NA|NA J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA HIMHAPGP_00582 1090318.ATTI01000001_gene1264 1.4e-101 376.3 Sphingomonadales accA 2.1.3.15,6.4.1.2 ko:K01962,ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 Bacteria 1MURN@1224,2K0BW@204457,2TR6V@28211,COG0825@1,COG0825@2 NA|NA|NA I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA HIMHAPGP_00583 1248916.ANFY01000003_gene556 5.4e-81 308.5 Sphingomonadales MA20_40030 Bacteria 1QTT7@1224,2K1IX@204457,2TTU7@28211,COG4784@1,COG4784@2 NA|NA|NA S peptidase M48, Ste24p HIMHAPGP_00584 1205680.CAKO01000002_gene2402 2.6e-40 171.4 Rhodospirillales mutT GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008413,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017110,GO:0030145,GO:0033554,GO:0034641,GO:0035539,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044715,GO:0044716,GO:0046483,GO:0046872,GO:0046914,GO:0047429,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 3.6.1.55,3.6.1.65 ko:K03574,ko:K08320 ko00000,ko01000,ko03400 iE2348C_1286.E2348C_0104,iSDY_1059.SDY_0129 Bacteria 1RCZM@1224,2JS44@204441,2U7A4@28211,COG0494@1,COG0494@2 NA|NA|NA JL Belongs to the Nudix hydrolase family HIMHAPGP_00585 504832.OCAR_4055 3.3e-18 97.4 Bradyrhizobiaceae MA20_40075 Bacteria 1N72W@1224,2UBU4@28211,3K02F@41294,COG2261@1,COG2261@2 NA|NA|NA S Transglycosylase associated protein HIMHAPGP_00586 745310.G432_09360 4.4e-227 794.7 Sphingomonadales rne 3.1.26.12 ko:K08300 ko03018,map03018 M00394 ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 Bacteria 1MV65@1224,2K00N@204457,2TRX2@28211,COG1530@1,COG1530@2 NA|NA|NA J Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs HIMHAPGP_00587 1550073.JROH01000018_gene452 2e-51 210.3 Sphingomonadales fliD GO:0001539,GO:0003674,GO:0005198,GO:0005575,GO:0005576,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009420,GO:0009421,GO:0009424,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588 ko:K02407 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 1MUVP@1224,2K0ZT@204457,2TQNV@28211,COG1345@1,COG1345@2 NA|NA|NA N Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end HIMHAPGP_00588 1030157.AFMP01000050_gene6 1e-08 66.6 Sphingomonadales fliS GO:0001539,GO:0003674,GO:0005198,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588 ko:K02422 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 1NAKB@1224,2K72I@204457,2UIG0@28211,COG1516@1,COG1516@2 NA|NA|NA N flagellar protein HIMHAPGP_00589 1248916.ANFY01000003_gene619 4.7e-139 501.1 Sphingomonadales cpg2 3.4.17.11 ko:K01295 ko00000,ko01000,ko01002 Bacteria 1MUSU@1224,2K0AC@204457,2TRTW@28211,COG0624@1,COG0624@2 NA|NA|NA E COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases HIMHAPGP_00590 1234595.C725_0644 2.3e-160 572.4 unclassified Alphaproteobacteria ilvG 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 Bacteria 1MU6U@1224,2TSB1@28211,4BPW8@82117,COG0028@1,COG0028@2 NA|NA|NA EH Thiamine pyrophosphate enzyme, central domain HIMHAPGP_00592 745310.G432_02005 2e-92 345.5 Sphingomonadales cobB GO:0002252,GO:0002376,GO:0003674,GO:0003824,GO:0006464,GO:0006476,GO:0006807,GO:0006935,GO:0006950,GO:0006952,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009615,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018205,GO:0019213,GO:0019538,GO:0033558,GO:0034979,GO:0034983,GO:0035601,GO:0036048,GO:0036049,GO:0036055,GO:0036211,GO:0040011,GO:0042221,GO:0042330,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0051607,GO:0051704,GO:0051707,GO:0071704,GO:0098542,GO:0098732,GO:0140096,GO:1901564 ko:K12410 ko00000,ko01000 Bacteria 1MUK1@1224,2K1HB@204457,2TV1Q@28211,COG0846@1,COG0846@2 NA|NA|NA K NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form HIMHAPGP_00593 1123269.NX02_10715 4.2e-130 471.1 Sphingomonadales bioB GO:0003674,GO:0003824,GO:0004076,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0017144,GO:0018130,GO:0019752,GO:0030312,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0070283,GO:0071704,GO:0071944,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1589,iZ_1308.Z0994 Bacteria 1MVFF@1224,2K19B@204457,2TSD6@28211,COG0502@1,COG0502@2 NA|NA|NA H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism HIMHAPGP_00594 1248760.ANFZ01000011_gene204 3.7e-129 468.0 Sphingomonadales thiG GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.10 ko:K03149 ko00730,ko01100,map00730,map01100 R10247 RC03096,RC03097,RC03461 ko00000,ko00001,ko01000 Bacteria 1N0N5@1224,2K0MM@204457,2TSXS@28211,COG2022@1,COG2022@2 NA|NA|NA H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S HIMHAPGP_00595 1248916.ANFY01000004_gene1749 1e-51 209.5 Sphingomonadales aroQ 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 iIT341.HP1038 Bacteria 1RDDT@1224,2K3VV@204457,2U9BV@28211,COG0757@1,COG0757@2 NA|NA|NA E Catalyzes a trans-dehydration via an enolate intermediate HIMHAPGP_00596 392499.Swit_4699 6.2e-39 167.2 Sphingomonadales accB GO:0003674,GO:0003824,GO:0003989,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009305,GO:0009987,GO:0016049,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576 2.3.1.12 ko:K00627,ko:K02160 ko00010,ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00010,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00307,M00376 R00209,R00742,R02569 RC00004,RC00040,RC00367,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1RCXA@1224,2K5JX@204457,2U93Y@28211,COG0511@1,COG0511@2 NA|NA|NA I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA HIMHAPGP_00597 1123269.NX02_06730 1.1e-192 679.5 Sphingomonadales accC GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 Bacteria 1MU4H@1224,2K11Z@204457,2U25Z@28211,COG0439@1,COG0439@2 NA|NA|NA I An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism HIMHAPGP_00598 1248916.ANFY01000003_gene706 7.7e-272 943.3 Sphingomonadales mgpS 3.6.4.13 ko:K17675 ko00000,ko01000,ko03029 Bacteria 1MVD6@1224,2JZXM@204457,2TR7N@28211,COG4581@1,COG4581@2 NA|NA|NA L helicase HIMHAPGP_00599 627192.SLG_34020 3e-51 207.6 Sphingomonadales fdxA ko:K05524 ko00000 Bacteria 1RH5I@1224,2K4E8@204457,2U98K@28211,COG1146@1,COG1146@2 NA|NA|NA C Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions HIMHAPGP_00600 13690.CP98_03789 4.5e-70 271.2 Sphingomonadales MA20_34195 ko:K03710,ko:K05836 ko00000,ko03000 Bacteria 1MVFM@1224,2K412@204457,2U5HC@28211,COG2188@1,COG2188@2 NA|NA|NA K histidine utilization repressor HIMHAPGP_00601 1123269.NX02_15335 2e-157 562.4 Sphingomonadales hutF 3.5.3.13 ko:K05603 ko00340,map00340 R02286 RC00682 ko00000,ko00001,ko01000 Bacteria 1MUFE@1224,2K26T@204457,2TR3A@28211,COG0402@1,COG0402@2 NA|NA|NA F deiminase HIMHAPGP_00602 13690.CP98_03787 3.9e-154 551.2 Sphingomonadales hutI 3.5.2.7 ko:K01468 ko00340,ko01100,map00340,map01100 M00045 R02288 RC00683 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUYR@1224,2K2MP@204457,2TSA1@28211,COG1228@1,COG1228@2 NA|NA|NA Q Catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway HIMHAPGP_00603 1096930.L284_18155 1.1e-217 762.7 Sphingomonadales hutH GO:0003674,GO:0003824,GO:0004397,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016840,GO:0016841,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564 4.3.1.3 ko:K01745 ko00340,ko01100,map00340,map01100 M00045 R01168 RC00361 ko00000,ko00001,ko00002,ko01000 Bacteria 1MU6K@1224,2K1IZ@204457,2TSPJ@28211,COG2986@1,COG2986@2 NA|NA|NA E Histidine HIMHAPGP_00604 13690.CP98_03785 7e-102 377.1 Sphingomonadales hutG 3.5.1.68,3.5.3.8 ko:K01458,ko:K01479 ko00340,ko00630,ko01100,map00340,map00630,map01100 M00045 R00525,R02285 RC00165,RC00221,RC00323,RC00681 ko00000,ko00001,ko00002,ko01000 Bacteria 1MY4D@1224,2K0GJ@204457,2TSC3@28211,COG3741@1,COG3741@2 NA|NA|NA E N-formylglutamate amidohydrolase HIMHAPGP_00605 1333998.M2A_0140 9.7e-10 69.3 unclassified Alphaproteobacteria acsA 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 1MUF5@1224,2TRKS@28211,4BP7M@82117,COG0365@1,COG0365@2 NA|NA|NA I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA HIMHAPGP_00606 1174684.EBMC1_12195 9.6e-183 646.4 Sphingomonadales gluP ko:K02429 ko00000,ko02000 2.A.1.7 Bacteria 1MXDC@1224,2K028@204457,2TSVP@28211,COG0738@1,COG0738@2 NA|NA|NA G Transporter HIMHAPGP_00607 745310.G432_17590 7.3e-68 263.8 Sphingomonadales ko:K11209 ko00000,ko01000 Bacteria 1MUN3@1224,2KCX1@204457,2TTVR@28211,COG0625@1,COG0625@2 NA|NA|NA O Belongs to the GST superfamily HIMHAPGP_00608 1248916.ANFY01000007_gene2615 1e-126 460.3 Sphingomonadales Bacteria 1MVSC@1224,2KER5@204457,2TXB0@28211,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily HIMHAPGP_00610 1114964.L485_23850 5.2e-32 144.8 Sphingomonadales Bacteria 1NEK8@1224,2C5U9@1,2K10J@204457,2U4EQ@28211,2Z9NJ@2 NA|NA|NA S Bacterial protein of unknown function (Gcw_chp) HIMHAPGP_00611 1090318.ATTI01000001_gene2825 1.2e-259 902.5 Sphingomonadales parE GO:0000819,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0022402,GO:0030541,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0098813,GO:0140097,GO:1901360 5.99.1.3 ko:K02470,ko:K02622 ko00000,ko01000,ko02048,ko03032,ko03036,ko03400 Bacteria 1MVH1@1224,2K2GE@204457,2TQZV@28211,COG0187@1,COG0187@2 NA|NA|NA L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule HIMHAPGP_00612 266264.Rmet_5667 1.1e-33 149.4 Burkholderiaceae Bacteria 1K8IY@119060,1R3CD@1224,2AY0M@1,2WIGT@28216,32Z2S@2 NA|NA|NA S Phospholipase_D-nuclease N-terminal HIMHAPGP_00613 1123240.ATVO01000003_gene449 1.5e-69 270.8 Sphingomonadales Bacteria 1MYB8@1224,2K0KS@204457,2TQV5@28211,COG0457@1,COG0457@2 NA|NA|NA S COG0457 FOG TPR repeat HIMHAPGP_00614 1090319.KE386571_gene308 8e-66 257.3 Sphingomonadales ispE GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006629,GO:0006720,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0050515,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901576 2.1.1.182,2.7.1.148 ko:K00919,ko:K02528,ko:K16924 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096,M00582 R05634,R10716 RC00002,RC00003,RC01439,RC03257 ko00000,ko00001,ko00002,ko01000,ko02000,ko03009 3.A.1.29 iEC55989_1330.EC55989_1304,iLJ478.TM1383,iYO844.BSU00460 Bacteria 1MVU3@1224,2K1QE@204457,2TUFV@28211,COG1947@1,COG1947@2 NA|NA|NA I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol HIMHAPGP_00615 392499.Swit_0075 6.6e-91 340.9 Sphingomonadales sua5 GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 2.7.7.87 ko:K07566 R10463 RC00745 ko00000,ko01000,ko03009,ko03016 Bacteria 1MVPM@1224,2K1JS@204457,2TRIM@28211,COG0009@1,COG0009@2 NA|NA|NA J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine HIMHAPGP_00616 1234595.C725_2906 1.3e-206 726.1 unclassified Alphaproteobacteria acd GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016627,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050662,GO:0052890,GO:0055114,GO:0097159,GO:1901265,GO:1901363 ko:K20035 ko00920,map00920 R11130 RC03363 ko00000,ko00001,ko01000 Bacteria 1MU20@1224,2TQJS@28211,4BP9N@82117,COG1960@1,COG1960@2 NA|NA|NA I Acetyl-CoA dehydrogenase C-terminal like HIMHAPGP_00617 1248916.ANFY01000007_gene2336 3.5e-62 245.0 Alphaproteobacteria Bacteria 1P3ST@1224,2A6C7@1,2UU37@28211,30V51@2 NA|NA|NA HIMHAPGP_00618 595536.ADVE02000001_gene3693 7.4e-51 207.6 Methylocystaceae cysQ 2.7.7.4,3.1.3.7 ko:K00957,ko:K01082 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00188,R00508,R00529,R04929 RC00078,RC02809,RC02889 ko00000,ko00001,ko00002,ko01000,ko03016 Bacteria 1N0GY@1224,2TT7B@28211,36Y1H@31993,COG1218@1,COG1218@2 NA|NA|NA P Inositol monophosphatase family HIMHAPGP_00619 1002809.SSIL_2408 6.9e-192 677.2 Planococcaceae 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQE8@1239,26DUZ@186818,4H9VR@91061,COG0028@1,COG0028@2 NA|NA|NA E COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase HIMHAPGP_00620 236097.ADG881_776 1.2e-81 309.7 Gammaproteobacteria ko:K07090 ko00000 Bacteria 1P10Q@1224,1RY3A@1236,COG0730@1,COG0730@2 NA|NA|NA S membrane transporter protein HIMHAPGP_00621 301.JNHE01000002_gene2120 1e-70 273.5 Pseudomonas aeruginosa group Bacteria 1NH6F@1224,1S0XK@1236,1YFDV@136841,COG0300@1,COG0300@2 NA|NA|NA S KR domain HIMHAPGP_00622 1288826.MSNKSG1_15017 2.6e-108 398.7 Alteromonadaceae 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 Bacteria 1N8PG@1224,1RWCX@1236,469BZ@72275,COG0451@1,COG0451@2 NA|NA|NA GM NAD-dependent epimerase dehydratase HIMHAPGP_00623 1112212.JH584235_gene2885 4e-63 247.3 Sphingomonadales hutU 4.2.1.49 ko:K01712 ko00340,ko01100,map00340,map01100 M00045 R02914 RC00804 ko00000,ko00001,ko00002,ko01000 Bacteria 1MU4W@1224,2K2BT@204457,2TSJR@28211,COG2987@1,COG2987@2 NA|NA|NA E Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate HIMHAPGP_00625 1248916.ANFY01000009_gene169 9e-125 453.4 Sphingomonadales trxB GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.9 ko:K00384,ko:K03671 ko00450,ko04621,ko05418,map00450,map04621,map05418 R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000,ko03110 iNJ661.Rv3913 Bacteria 1MV15@1224,2K0I2@204457,2TRBW@28211,COG0492@1,COG0492@2 NA|NA|NA C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family HIMHAPGP_00626 1248916.ANFY01000009_gene168 6.1e-107 394.0 Sphingomonadales MA20_05050 Bacteria 1MWVB@1224,2K06T@204457,2TQXV@28211,COG0583@1,COG0583@2 NA|NA|NA K Transcriptional regulator HIMHAPGP_00629 1437824.BN940_14221 1e-229 802.7 Betaproteobacteria Bacteria 1MV2R@1224,2VRSD@28216,COG1233@1,COG1233@2 NA|NA|NA Q Flavin containing amine oxidoreductase HIMHAPGP_00630 1437824.BN940_14226 1.4e-221 775.8 Alcaligenaceae Bacteria 1MV2R@1224,2VRSD@28216,3T726@506,COG1233@1,COG1233@2 NA|NA|NA Q Flavin containing amine oxidoreductase HIMHAPGP_00631 314225.ELI_12590 7.4e-177 627.1 Sphingomonadales MA20_16355 6.2.1.3 ko:K00666,ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 Bacteria 1MU6G@1224,2K1MV@204457,2TR2W@28211,COG0318@1,COG0318@2 NA|NA|NA IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II HIMHAPGP_00633 1248916.ANFY01000008_gene2140 6.1e-37 161.0 Sphingomonadales Bacteria 1NKNK@1224,29Y62@1,2K7QH@204457,2UKHF@28211,30JZF@2 NA|NA|NA S PEP-CTERM motif HIMHAPGP_00634 204669.Acid345_3877 5.7e-35 154.5 Bacteria yiiM GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009636,GO:0009987,GO:0019748,GO:0042221,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0098754 Bacteria COG2258@1,COG2258@2 NA|NA|NA C MOSC domain HIMHAPGP_00635 1123269.NX02_00330 5.8e-305 1053.1 Sphingomonadales purL GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 Bacteria 1MYN4@1224,2K25A@204457,2TRGM@28211,COG0046@1,COG0046@2 NA|NA|NA F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL HIMHAPGP_00637 1331060.RLDS_07635 1.2e-32 145.6 Sphingomonadales Bacteria 1MU23@1224,2JZVS@204457,2TS2G@28211,COG0582@1,COG0582@2 NA|NA|NA L Belongs to the 'phage' integrase family HIMHAPGP_00640 314225.ELI_05735 3.2e-13 81.3 Alphaproteobacteria Bacteria 1RAWV@1224,2C2XI@1,2U5X3@28211,30D1S@2 NA|NA|NA HIMHAPGP_00641 314225.ELI_05735 6.8e-19 100.1 Alphaproteobacteria Bacteria 1RAWV@1224,2C2XI@1,2U5X3@28211,30D1S@2 NA|NA|NA HIMHAPGP_00642 358220.C380_01130 1.2e-51 209.5 Comamonadaceae ko:K22294 ko00000,ko03000 Bacteria 1R5SG@1224,2VNT5@28216,4ABGC@80864,COG1309@1,COG1309@2 NA|NA|NA K PFAM regulatory protein TetR HIMHAPGP_00643 1502850.FG91_02804 2.7e-126 458.8 Sphingomonadales 2.1.1.14 ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R04405,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUI9@1224,2K3CA@204457,2TTWK@28211,COG0620@1,COG0620@2 NA|NA|NA E Cobalamin-independent synthase, Catalytic domain HIMHAPGP_00644 62928.azo2937 1.8e-26 125.2 Rhodocyclales nirM ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 Bacteria 1N6UN@1224,2KX86@206389,2VW1Y@28216,COG4654@1,COG4654@2 NA|NA|NA C Cytochrome c HIMHAPGP_00645 1121035.AUCH01000016_gene2118 2.4e-261 907.9 Rhodocyclales nirS GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.7.2.1,1.7.99.1 ko:K15864 ko00910,ko01120,map00910,map01120 M00529 R00143,R00783,R00785 RC00086,RC02797 ko00000,ko00001,ko00002,ko01000 Bacteria 1N3PN@1224,2KVT2@206389,2VHSF@28216,COG2010@1,COG2010@2 NA|NA|NA C Cytochrome D1 heme domain HIMHAPGP_00646 1248916.ANFY01000003_gene747 2.8e-105 388.3 Sphingomonadales Bacteria 1MWAK@1224,2K142@204457,2TT2N@28211,COG3173@1,COG3173@2 NA|NA|NA S Aminoglycoside phosphotransferase HIMHAPGP_00648 1123240.ATVO01000004_gene925 2.1e-137 495.7 Sphingomonadales tlyC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03699 ko00000,ko02042 Bacteria 1MV3P@1224,2K087@204457,2TS80@28211,COG1253@1,COG1253@2 NA|NA|NA S COG1253 Hemolysins and related proteins containing CBS domains HIMHAPGP_00649 1219049.SP5_046_00030 3e-45 188.7 Sphingomonadales yiaD Bacteria 1MYBP@1224,2K074@204457,2U787@28211,COG2885@1,COG2885@2 NA|NA|NA M Belongs to the ompA family HIMHAPGP_00650 745310.G432_11785 1.3e-113 416.4 Sphingomonadales pheT GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iG2583_1286.G2583_2160,iPC815.YPO2428 Bacteria 1MWKS@1224,2K02I@204457,2TQV8@28211,COG0072@1,COG0072@2,COG0073@1,COG0073@2 NA|NA|NA J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily HIMHAPGP_00652 745310.G432_03860 6e-18 96.7 Sphingomonadales sdhE GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006105,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016043,GO:0016999,GO:0017013,GO:0017144,GO:0018065,GO:0018293,GO:0019538,GO:0019752,GO:0022607,GO:0034552,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0043648,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0045333,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072350,GO:1901564 1.3.5.1,1.3.5.4 ko:K00240,ko:K09159 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000,ko02048 Bacteria 1N6SJ@1224,2K5W5@204457,2VCGJ@28211,COG2938@1,COG2938@2 NA|NA|NA S Flavinator of succinate dehydrogenase HIMHAPGP_00653 1030157.AFMP01000044_gene1790 3.8e-213 748.0 Sphingomonadales recG GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 ko:K03655 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 1MWN2@1224,2K0MC@204457,2TR86@28211,COG1200@1,COG1200@2 NA|NA|NA L ATP-dependent DNA helicase RecG HIMHAPGP_00655 1248916.ANFY01000011_gene1165 7.9e-142 510.4 Sphingomonadales tyrS GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0030312,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 Bacteria 1MVUQ@1224,2K11C@204457,2TQPA@28211,COG0162@1,COG0162@2 NA|NA|NA J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) HIMHAPGP_00656 1090318.ATTI01000001_gene2514 5.6e-94 351.3 Sphingomonadales anmK 2.7.1.170 ko:K09001 ko00000,ko01000 Bacteria 1MV4E@1224,2K0SC@204457,2TS4G@28211,COG2377@1,COG2377@2 NA|NA|NA O Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling HIMHAPGP_00657 1030157.AFMP01000062_gene3549 1.2e-110 407.5 Sphingomonadales Bacteria 1MV0P@1224,2KCM2@204457,2U2U5@28211,COG3629@1,COG3629@2 NA|NA|NA K DNA-binding transcriptional activator of the SARP family HIMHAPGP_00658 1030157.AFMP01000062_gene3550 3.8e-43 181.8 Sphingomonadales Bacteria 1QG2J@1224,2K4WX@204457,2TUJJ@28211,COG3482@1,COG3482@2 NA|NA|NA S TfuA-like protein HIMHAPGP_00659 1194165.CAJF01000001_gene1876 4.9e-28 132.1 Microbacteriaceae ctpE GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 ko:K12952 ko00000,ko01000 3.A.3.23 Bacteria 2GJJC@201174,4FMJ8@85023,COG0474@1,COG0474@2 NA|NA|NA P E1-E2 ATPase HIMHAPGP_00660 1174684.EBMC1_09359 3.8e-167 594.3 Sphingomonadales rpsA 1.17.7.4 ko:K02945,ko:K03527 ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010 M00096,M00178 R05884,R08210 RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko03011 Bacteria 1MVAV@1224,2K0KT@204457,2TQPV@28211,COG0539@1,COG0539@2 NA|NA|NA J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence HIMHAPGP_00661 392499.Swit_2409 6.3e-31 139.8 Sphingomonadales himD GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2001141 ko:K05788 ko00000,ko03032,ko03036,ko03400 Bacteria 1MZ7M@1224,2K633@204457,2UBR5@28211,COG0776@1,COG0776@2 NA|NA|NA K This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control HIMHAPGP_00662 1297569.MESS2_1650024 4.3e-288 997.3 Phyllobacteriaceae cadA 3.6.3.3,3.6.3.5 ko:K01534 ko00000,ko01000 3.A.3.6 Bacteria 1MU08@1224,2TR56@28211,43I1A@69277,COG2217@1,COG2217@2 NA|NA|NA P E1-E2 ATPase HIMHAPGP_00663 13690.CP98_03447 1.5e-34 153.3 Sphingomonadales fnrL ko:K01420 ko00000,ko03000 Bacteria 1MVGE@1224,2K40D@204457,2TV0E@28211,COG0664@1,COG0664@2 NA|NA|NA K CRP FNR family HIMHAPGP_00664 1123269.NX02_10425 1.5e-77 295.8 Sphingomonadales serS GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004828,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006434,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009059,GO:0009069,GO:0009070,GO:0009987,GO:0010467,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iAF987.Gmet_3528,iSDY_1059.SDY_2368 Bacteria 1MUJF@1224,2K0IX@204457,2TR4T@28211,COG0172@1,COG0172@2 NA|NA|NA J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) HIMHAPGP_00665 1248916.ANFY01000003_gene486 1.2e-92 346.3 Sphingomonadales surE 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 Bacteria 1MVHE@1224,2K0F4@204457,2TQXZ@28211,COG0496@1,COG0496@2 NA|NA|NA S Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates HIMHAPGP_00667 194867.ALBQ01000003_gene1181 8.9e-77 293.5 Sphingomonadales sodA 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 ko00000,ko00001,ko01000 Bacteria 1MVW2@1224,2K112@204457,2TU3T@28211,COG0605@1,COG0605@2 NA|NA|NA P Destroys radicals which are normally produced within the cells and which are toxic to biological systems HIMHAPGP_00668 1042375.AFPL01000013_gene2412 1.3e-11 75.5 Alteromonadaceae Bacteria 1N9FF@1224,1SG3E@1236,46C4U@72275,COG0508@1,COG0508@2 NA|NA|NA C Biotin-requiring enzyme HIMHAPGP_00669 1234595.C725_1977 1.9e-150 539.3 unclassified Alphaproteobacteria glpD GO:0000166,GO:0003674,GO:0003824,GO:0004368,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005887,GO:0006072,GO:0006091,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009331,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016614,GO:0016901,GO:0019637,GO:0022900,GO:0031224,GO:0031226,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046168,GO:0046434,GO:0048037,GO:0050660,GO:0050662,GO:0052590,GO:0052646,GO:0055114,GO:0071704,GO:0071944,GO:0071949,GO:0097159,GO:1901135,GO:1901136,GO:1901265,GO:1901363,GO:1901575,GO:1902494,GO:1990204 1.1.1.402,1.1.5.3 ko:K00111,ko:K21054 ko00564,ko01110,map00564,map01110 R00848 RC00029 ko00000,ko00001,ko01000 iSSON_1240.SSON_3663 Bacteria 1MUMY@1224,2TU11@28211,4BPQ9@82117,COG0578@1,COG0578@2 NA|NA|NA C C-terminal domain of alpha-glycerophosphate oxidase HIMHAPGP_00670 1081640.AGFU01000002_gene448 1.8e-56 225.7 Sphingomonadales pdxH GO:0003674,GO:0003824,GO:0004733,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016638,GO:0016641,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 1.4.3.5 ko:K00275 ko00750,ko01100,ko01120,map00750,map01100,map01120 M00124 R00277,R00278,R01710,R01711 RC00048,RC00116 ko00000,ko00001,ko00002,ko01000 Bacteria 1NZUU@1224,2K0J3@204457,2TT1U@28211,COG0259@1,COG0259@2 NA|NA|NA H Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) HIMHAPGP_00671 1123267.JONN01000001_gene397 7.6e-73 280.8 Sphingomonadales dnaJ1 ko:K03686,ko:K05516 ko00000,ko03029,ko03036,ko03110 Bacteria 1MUZ4@1224,2K1JP@204457,2TR01@28211,COG0484@1,COG0484@2 NA|NA|NA O molecular chaperone HIMHAPGP_00672 1112214.AHIS01000082_gene3654 2.1e-51 209.5 Sphingomonadales rbn ko:K07058 ko00000 Bacteria 1MXQA@1224,2K0UY@204457,2TTN5@28211,COG1295@1,COG1295@2 NA|NA|NA S ribonuclease BN HIMHAPGP_00673 1112214.AHIS01000082_gene3655 2e-114 418.7 Sphingomonadales fabI GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:1901576 1.3.1.10,1.3.1.9 ko:K00208 ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212 M00083,M00572 R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 1MV05@1224,2K0BH@204457,2TSU4@28211,COG0623@1,COG0623@2 NA|NA|NA I Enoyl- acyl-carrier-protein reductase NADH HIMHAPGP_00676 530564.Psta_0981 4.5e-34 151.0 Planctomycetes Bacteria 2E2PZ@1,2J0CQ@203682,32XST@2 NA|NA|NA HIMHAPGP_00677 1234595.C725_2676 2.7e-23 114.0 Alphaproteobacteria fadE ko:K06446 ko00930,ko01100,ko01120,map00930,map01100,map01120 R06943 RC00052 ko00000,ko00001,ko01000 Bacteria 1MUDR@1224,2TQKE@28211,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase HIMHAPGP_00678 392499.Swit_3985 6.5e-47 193.7 Sphingomonadales ko:K13643 ko00000,ko03000 Bacteria 1RDA4@1224,2K4I1@204457,2U9GW@28211,COG1959@1,COG1959@2 NA|NA|NA K Transcriptional regulator HIMHAPGP_00679 392499.Swit_2962 4.2e-172 610.9 Sphingomonadales rlmN GO:0000049,GO:0000154,GO:0001510,GO:0002935,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016426,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0070040,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:0140102,GO:1901360,GO:1901363 2.1.1.192 ko:K06941 ko00000,ko01000,ko03009 Bacteria 1MUYK@1224,2K0CT@204457,2TQT3@28211,COG0820@1,COG0820@2 NA|NA|NA J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HIMHAPGP_00680 1000565.METUNv1_03437 1.5e-09 70.1 Betaproteobacteria Bacteria 1NIUV@1224,2DPR4@1,2VYN6@28216,3331K@2 NA|NA|NA S PEP-CTERM motif HIMHAPGP_00682 745310.G432_02075 2.9e-28 132.1 Sphingomonadales Bacteria 1N3CI@1224,2FE0D@1,2K1ZS@204457,2UDQQ@28211,3460K@2 NA|NA|NA HIMHAPGP_00683 1248916.ANFY01000016_gene79 1.9e-25 121.7 Sphingomonadales Bacteria 1Q4V4@1224,2K6UF@204457,2VB9X@28211,COG3255@1,COG3255@2 NA|NA|NA I PFAM Sterol-binding domain protein HIMHAPGP_00685 1549858.MC45_09080 1e-60 241.1 Sphingomonadales lipB GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0016874,GO:0016879,GO:0016979,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019222,GO:0019538,GO:0019752,GO:0032787,GO:0033819,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048519,GO:0050789,GO:0051186,GO:0051188,GO:0051604,GO:0060255,GO:0065007,GO:0071704,GO:0072330,GO:0140096,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.3.1.181,2.8.1.8 ko:K03644,ko:K03801 ko00785,ko01100,map00785,map01100 R07766,R07767,R07768,R07769 RC00039,RC00992,RC01978,RC02867 ko00000,ko00001,ko01000 iECSF_1327.ECSF_0569,iSFV_1184.SFV_0696,iSFxv_1172.SFxv_0718 Bacteria 1MU6A@1224,2K28T@204457,2TRXJ@28211,COG0321@1,COG0321@2 NA|NA|NA H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate HIMHAPGP_00686 1248916.ANFY01000007_gene2204 1.3e-28 132.5 Sphingomonadales Bacteria 1MU6Y@1224,2K0VP@204457,2TRYI@28211,COG0277@1,COG0277@2 NA|NA|NA C FAD linked HIMHAPGP_00687 1248916.ANFY01000007_gene2203 3.8e-78 298.1 Sphingomonadales Bacteria 1Q227@1224,2K0P1@204457,2U2IQ@28211,COG1262@1,COG1262@2 NA|NA|NA S SapC HIMHAPGP_00688 1121028.ARQE01000011_gene250 7.9e-42 177.2 Aurantimonadaceae Bacteria 1R9XD@1224,2PK0N@255475,2TVD3@28211,COG2353@1,COG2353@2 NA|NA|NA S YceI-like domain HIMHAPGP_00689 685778.AORL01000021_gene251 2.3e-35 155.6 Sphingomonadales ko:K12262 ko00000 Bacteria 1MZ7X@1224,2K5G9@204457,2UBYU@28211,COG3038@1,COG3038@2 NA|NA|NA C Prokaryotic cytochrome b561 HIMHAPGP_00690 1502850.FG91_01964 5e-16 90.1 Sphingomonadales xseB GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494 3.1.11.6 ko:K03602 ko03430,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 1PTYQ@1224,2K6WZ@204457,2UFD6@28211,COG1722@1,COG1722@2 NA|NA|NA L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides HIMHAPGP_00691 1248916.ANFY01000011_gene1090 1.3e-112 412.9 Sphingomonadales ispA GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009536,GO:0009842,GO:0009987,GO:0016114,GO:0016740,GO:0016765,GO:0019637,GO:0033385,GO:0033386,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0090407,GO:1901576 2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90 ko:K00795,ko:K02523,ko:K13789 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00366 R01658,R02003,R02061,R09248 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 Bacteria 1MWNG@1224,2K19H@204457,2TR79@28211,COG0142@1,COG0142@2 NA|NA|NA H Belongs to the FPP GGPP synthase family HIMHAPGP_00692 392499.Swit_0023 1.9e-62 245.4 Sphingomonadales coaD GO:0003674,GO:0003824,GO:0004595,GO:0005488,GO:0005515,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0015939,GO:0015940,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046390,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 iPC815.YPO0053,iSDY_1059.SDY_4064 Bacteria 1RD9F@1224,2K1RJ@204457,2U74H@28211,COG0669@1,COG0669@2 NA|NA|NA H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate HIMHAPGP_00693 1007104.SUS17_2978 9.1e-61 240.4 Sphingomonadales 5.2.1.8 ko:K01802,ko:K03768 ko00000,ko01000,ko03110 Bacteria 1R9ZQ@1224,2KCVY@204457,2U591@28211,COG0652@1,COG0652@2 NA|NA|NA O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides HIMHAPGP_00696 1545915.JROG01000003_gene1234 8.6e-225 786.6 Sphingomonadales Bacteria 1MUBX@1224,2K0GU@204457,2TSUQ@28211,COG4805@1,COG4805@2 NA|NA|NA O protein conserved in bacteria HIMHAPGP_00697 1112214.AHIS01000083_gene3608 3e-88 332.4 Sphingomonadales 1.14.14.12 ko:K16047 ko00984,ko01100,ko01120,map00984,map01100,map01120 R09819 RC00236 ko00000,ko00001,ko01000 Bacteria 1MXMQ@1224,2K5X9@204457,2TTF6@28211,COG1960@1,COG1960@2 NA|NA|NA I Acyl-CoA dehydrogenase, C-terminal domain HIMHAPGP_00698 1219035.NT2_01_05890 1.1e-26 126.3 Alphaproteobacteria Bacteria 1N7BN@1224,2UINK@28211,COG1846@1,COG1846@2 NA|NA|NA K MarR family HIMHAPGP_00699 1366050.N234_20055 2.4e-72 278.9 Burkholderiaceae Bacteria 1K7UG@119060,1PFUB@1224,2VP9J@28216,COG1028@1,COG1028@2 NA|NA|NA IQ Enoyl-(Acyl carrier protein) reductase HIMHAPGP_00700 1174684.EBMC1_15699 1.5e-21 109.4 Sphingomonadales Bacteria 1MZN0@1224,2K66W@204457,2U5DW@28211,COG1664@1,COG1664@2 NA|NA|NA M Integral membrane protein CcmA involved in cell shape determination HIMHAPGP_00701 1120705.FG95_02989 3.9e-82 312.0 Sphingomonadales Bacteria 1MVTF@1224,2K148@204457,2TQZE@28211,COG0739@1,COG0739@2 NA|NA|NA M COG0739 Membrane proteins related to metalloendopeptidases HIMHAPGP_00702 1449076.JOOE01000003_gene3304 1.6e-67 262.3 Sphingomonadales msrA 1.8.4.11 ko:K07304 ko00000,ko01000 Bacteria 1MVUS@1224,2K0CZ@204457,2TSAM@28211,COG0225@1,COG0225@2 NA|NA|NA O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine HIMHAPGP_00703 1248916.ANFY01000003_gene973 1e-90 340.5 Sphingomonadales Bacteria 1R56C@1224,2K9F3@204457,2UQZB@28211,COG5640@1,COG5640@2 NA|NA|NA O Trypsin-like serine protease HIMHAPGP_00704 1248916.ANFY01000011_gene1125 3.7e-221 774.2 Sphingomonadales gcvPB 1.4.4.2 ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 Bacteria 1MUDP@1224,2K1GP@204457,2TSFF@28211,COG1003@1,COG1003@2 NA|NA|NA E Glycine dehydrogenase (aminomethyl-transferring) HIMHAPGP_00705 1234595.C725_0617 6.5e-177 627.1 unclassified Alphaproteobacteria gcvPA GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006807,GO:0008150,GO:0008152,GO:0009069,GO:0009987,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019752,GO:0032991,GO:0042133,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901605,GO:1902494,GO:1990204 1.4.4.2 ko:K00281,ko:K00282 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 Bacteria 1MVC1@1224,2TR6C@28211,4BRF5@82117,COG0403@1,COG0403@2 NA|NA|NA E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HIMHAPGP_00706 745310.G432_01355 1.1e-74 286.6 Sphingomonadales 2.1.1.144,2.1.1.197,6.3.3.3 ko:K00598,ko:K01935,ko:K02169 ko00780,ko01100,map00780,map01100 M00123,M00572,M00573,M00577 R03182,R09543 RC00003,RC00460,RC00868 ko00000,ko00001,ko00002,ko01000 Bacteria 1R04W@1224,2K298@204457,2U5VR@28211,COG4106@1,COG4106@2 NA|NA|NA S Methionine biosynthesis protein MetW HIMHAPGP_00707 1248916.ANFY01000011_gene1128 4.6e-45 187.2 Sphingomonadales gcvH ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 Bacteria 1RGV7@1224,2K5E0@204457,2U9BY@28211,COG0509@1,COG0509@2 NA|NA|NA E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein HIMHAPGP_00708 1123240.ATVO01000005_gene1768 2e-147 528.9 Sphingomonadales gcvT GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008483,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0016769,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204 2.1.2.1,2.1.2.10 ko:K00600,ko:K00605 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R01221,R02300,R04125,R09099 RC00022,RC00069,RC00112,RC00183,RC01583,RC02834,RC02958 ko00000,ko00001,ko00002,ko01000 Bacteria 1MV96@1224,2K1GI@204457,2TRN4@28211,COG0404@1,COG0404@2 NA|NA|NA E Glycine cleavage system T protein HIMHAPGP_00710 1123269.NX02_08820 3.2e-145 521.5 Sphingomonadales Bacteria 1MWJK@1224,2K0D9@204457,2TSY7@28211,COG5267@1,COG5267@2 NA|NA|NA S Protein of unknown function (DUF1800) HIMHAPGP_00711 1120705.FG95_02778 2.5e-70 271.9 Sphingomonadales recR GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 ko:K06187 ko03440,map03440 ko00000,ko00001,ko03400 Bacteria 1MV9Q@1224,2K15N@204457,2TRZM@28211,COG0353@1,COG0353@2 NA|NA|NA L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO HIMHAPGP_00712 745310.G432_02985 5e-64 250.8 Sphingomonadales def GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.88 ko:K01462 ko00000,ko01000 Bacteria 1RA2P@1224,2K3Y2@204457,2U797@28211,COG0242@1,COG0242@2 NA|NA|NA J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions HIMHAPGP_00713 1219035.NT2_02_04290 2.5e-56 224.9 Sphingomonadales greB GO:0006139,GO:0006351,GO:0006352,GO:0006354,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010604,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031437,GO:0031439,GO:0032774,GO:0032784,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903311,GO:1903313,GO:1903506,GO:2000112,GO:2001141 ko:K04760 ko00000,ko03021 Bacteria 1RAP0@1224,2K3X2@204457,2U75V@28211,COG0782@1,COG0782@2 NA|NA|NA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length HIMHAPGP_00714 1248916.ANFY01000009_gene236 1.5e-121 443.7 Sphingomonadales slt ko:K08309 ko00000,ko01000,ko01011 GH23 Bacteria 1MV3F@1224,2K0PK@204457,2TRDB@28211,COG0741@1,COG0741@2 NA|NA|NA M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) HIMHAPGP_00715 392499.Swit_0517 2.1e-96 359.0 Sphingomonadales dapA GO:0003674,GO:0003824,GO:0006082,GO:0006090,GO:0008150,GO:0008152,GO:0008840,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044281,GO:0071704 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUCM@1224,2K09B@204457,2TR5W@28211,COG0329@1,COG0329@2 NA|NA|NA E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) HIMHAPGP_00716 745310.G432_18030 1.5e-64 252.3 Sphingomonadales smpB GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0070930,GO:0071704,GO:0097159,GO:1901363,GO:1901564 ko:K03664 ko00000 Bacteria 1RDFP@1224,2K3YM@204457,2U71I@28211,COG0691@1,COG0691@2 NA|NA|NA O Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene HIMHAPGP_00717 1248916.ANFY01000009_gene233 3.3e-83 314.7 Sphingomonadales yuiH Bacteria 1MWZK@1224,2K27H@204457,2TTCH@28211,COG2041@1,COG2041@2 NA|NA|NA S Oxidoreductase molybdopterin binding domain HIMHAPGP_00718 1335760.ASTG01000005_gene1171 3e-57 229.2 Sphingomonadales cckA 2.7.13.3 ko:K13587 ko02020,ko04112,map02020,map04112 M00512 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 1RCM9@1224,2K0WG@204457,2TQQ9@28211,COG0784@1,COG0784@2,COG4191@1,COG4191@2 NA|NA|NA T Histidine kinase HIMHAPGP_00721 1090320.KB900605_gene2171 9e-100 370.2 Sphingomonadales purU 3.5.1.10 ko:K01433 ko00630,ko00670,map00630,map00670 R00944 RC00026,RC00111 ko00000,ko00001,ko01000 Bacteria 1MVCF@1224,2K0F7@204457,2TR4V@28211,COG0788@1,COG0788@2 NA|NA|NA F Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) HIMHAPGP_00722 1123267.JONN01000001_gene2463 1.3e-121 442.6 Sphingomonadales adhC 1.1.1.1,1.1.1.284 ko:K00121 ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204 R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273 ko00000,ko00001,ko01000 Bacteria 1MUK4@1224,2K04T@204457,2TT67@28211,COG1062@1,COG1062@2 NA|NA|NA C Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily HIMHAPGP_00723 1234595.C725_1627 2.8e-64 251.9 unclassified Alphaproteobacteria argF GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUFM@1224,2TR81@28211,4BP6R@82117,COG0078@1,COG0078@2 NA|NA|NA E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline HIMHAPGP_00724 1234595.C725_1626 3.8e-77 295.0 unclassified Alphaproteobacteria hslO GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0006979,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0031647,GO:0036506,GO:0042026,GO:0042802,GO:0043167,GO:0043169,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0065007,GO:0065008 ko:K04083 ko00000,ko03110 Bacteria 1MUMU@1224,2TTUR@28211,4BQ76@82117,COG1281@1,COG1281@2 NA|NA|NA O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress HIMHAPGP_00725 1120705.FG95_03330 3.5e-283 981.1 Sphingomonadales Bacteria 1MWKN@1224,2K922@204457,2TTI2@28211,COG1629@1,COG4771@2 NA|NA|NA P TonB dependent receptor HIMHAPGP_00726 46429.BV95_02910 2.5e-19 100.9 Sphingomonadales ysgA 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 Bacteria 1MW7S@1224,2KDGA@204457,2TTPH@28211,COG0412@1,COG0412@2 NA|NA|NA Q Dienelactone hydrolase family HIMHAPGP_00727 441620.Mpop_1392 1.2e-30 139.0 Methylobacteriaceae sugE ko:K11741 ko00000,ko02000 2.A.7.1 Bacteria 1JV8T@119045,1MZ6P@1224,2UBR4@28211,COG2076@1,COG2076@2 NA|NA|NA P PFAM small multidrug resistance protein HIMHAPGP_00729 195253.Syn6312_3256 6.8e-22 111.7 Synechococcus wecA GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0034645,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0045229,GO:0046872,GO:0046914,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:1901576 2.7.8.33,2.7.8.35 ko:K02851 R08856 RC00002 ko00000,ko01000,ko01003,ko01005 Bacteria 1G1B9@1117,1GZBF@1129,COG0472@1,COG0472@2 NA|NA|NA M UDP-N-acetylmuramyl pentapeptide phosphotransferase UDP-N-acetylglucosamine-1-phosphate transferase HIMHAPGP_00730 1121861.KB899934_gene502 4.6e-86 325.9 Rhodospirillales ko:K01991 ko02026,map02026 ko00000,ko00001,ko02000 1.B.18 Bacteria 1N7GP@1224,2JQJN@204441,2U175@28211,COG1596@1,COG1596@2 NA|NA|NA M Capsule biosynthesis GfcC HIMHAPGP_00731 1550073.JROH01000018_gene456 5.5e-65 254.6 Sphingomonadales fliP ko:K02419,ko:K03226 ko02040,ko03070,map02040,map03070 M00332,M00542,M00660 ko00000,ko00001,ko00002,ko02035,ko02044 3.A.6.1,3.A.6.2,3.A.6.3 Bacteria 1MVBU@1224,2K12T@204457,2TT93@28211,COG1338@1,COG1338@2 NA|NA|NA N Plays a role in the flagellum-specific transport system HIMHAPGP_00733 426114.THI_1554 3.7e-11 75.1 unclassified Burkholderiales fliN GO:0005575,GO:0005623,GO:0005886,GO:0009288,GO:0009425,GO:0016020,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0071944 ko:K02417 ko02030,ko02040,map02030,map02040 ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 Bacteria 1KKUP@119065,1RGWT@1224,2VSZ7@28216,COG1886@1,COG1886@2 NA|NA|NA N Flagellar motor switch protein fliN HIMHAPGP_00735 1248916.ANFY01000011_gene1190 8.7e-23 113.6 Sphingomonadales fliL GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009425,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588 ko:K02415 ko00000,ko02035 Bacteria 1MYGB@1224,2K2E2@204457,2UAY8@28211,COG1580@1,COG1580@2 NA|NA|NA N Controls the rotational direction of flagella during chemotaxis HIMHAPGP_00738 1030157.AFMP01000040_gene1361 1.8e-107 396.4 Sphingomonadales fliI GO:0003674,GO:0005488,GO:0005515,GO:0042802 3.6.3.14 ko:K02412 ko02040,map02040 ko00000,ko00001,ko01000,ko02035,ko02044 3.A.6.2,3.A.6.3 Bacteria 1MUH6@1224,2JZWF@204457,2TRXU@28211,COG1157@1,COG1157@2 NA|NA|NA NU Flagellar biosynthesis type III secretory pathway ATPase HIMHAPGP_00740 627192.SLG_02920 1.4e-51 210.3 Sphingomonadales fliG GO:0001539,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006928,GO:0006996,GO:0008150,GO:0009288,GO:0009425,GO:0009987,GO:0016020,GO:0016043,GO:0022607,GO:0030030,GO:0030031,GO:0040011,GO:0042802,GO:0042803,GO:0042995,GO:0043226,GO:0043228,GO:0044085,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0044780,GO:0044781,GO:0046982,GO:0046983,GO:0048870,GO:0051179,GO:0051674,GO:0070925,GO:0071840,GO:0071944,GO:0071973,GO:0071978,GO:0097588 ko:K02410 ko02030,ko02040,map02030,map02040 ko00000,ko00001,ko02035 Bacteria 1MV9X@1224,2K1AA@204457,2TRIV@28211,COG1536@1,COG1536@2 NA|NA|NA N FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation HIMHAPGP_00741 1248916.ANFY01000011_gene1196 2.8e-78 299.7 Sphingomonadales fliF ko:K02409 ko02040,map02040 ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 Bacteria 1MUQR@1224,2K025@204457,2TR6J@28211,COG1766@1,COG1766@2 NA|NA|NA N The M ring may be actively involved in energy transduction HIMHAPGP_00742 1346791.M529_01450 5.3e-19 100.5 Sphingomonadales fliE ko:K02408 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 1PYK9@1224,2KDKC@204457,2UH17@28211,COG1677@1,COG1677@2 NA|NA|NA N Flagellar hook-basal body complex protein FliE HIMHAPGP_00743 1470591.BW41_02897 3.9e-79 302.0 Sphingomonadales flrC ko:K10943 ko02020,ko05111,map02020,map05111 M00515 ko00000,ko00001,ko00002,ko02022 Bacteria 1NU8B@1224,2K247@204457,2TW3X@28211,COG3829@1,COG3829@2 NA|NA|NA KT Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains HIMHAPGP_00744 1282361.ABAC402_01650 1.1e-136 493.0 Alphaproteobacteria pyrC GO:0003674,GO:0003824,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUYP@1224,2TT2U@28211,COG0418@1,COG0418@2 NA|NA|NA F Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate HIMHAPGP_00745 1206730.BAGA01000171_gene2190 9.6e-154 550.4 Nocardiaceae 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 Bacteria 2GM6Y@201174,4FZBM@85025,COG0028@1,COG0028@2 NA|NA|NA EH Thiamine pyrophosphate enzyme, central domain HIMHAPGP_00746 1123368.AUIS01000035_gene80 2.9e-45 188.3 Gammaproteobacteria 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 Bacteria 1RHZD@1224,1S7HV@1236,COG1622@1,COG1622@2 NA|NA|NA C PFAM Cytochrome C oxidase subunit II HIMHAPGP_00747 1123368.AUIS01000035_gene79 5e-151 541.2 Gammaproteobacteria coxA2 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 Bacteria 1QDZV@1224,1RYXY@1236,COG0843@1,COG0843@2 NA|NA|NA C PFAM cytochrome c oxidase subunit I HIMHAPGP_00748 76114.ebA3668 6.2e-39 167.5 Betaproteobacteria ko:K07152 ko00000,ko03029 Bacteria 1N17T@1224,2VWQT@28216,COG1999@1,COG1999@2 NA|NA|NA S SCO1/SenC HIMHAPGP_00749 1266908.AQPB01000060_gene178 3.5e-31 141.7 Proteobacteria Bacteria 1MZBH@1224,2CFGU@1,32SXK@2 NA|NA|NA HIMHAPGP_00752 194867.ALBQ01000011_gene216 2.9e-91 341.7 Sphingomonadales ubiE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016020,GO:0016740,GO:0016741,GO:0032259,GO:0040007,GO:0044424,GO:0044464,GO:0071944 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 Bacteria 1MX8I@1224,2K080@204457,2TRWR@28211,COG0500@1,COG2226@2 NA|NA|NA H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) HIMHAPGP_00753 1030157.AFMP01000031_gene2864 1.4e-86 326.2 Sphingomonadales fpg GO:0000702,GO:0000703,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008270,GO:0008534,GO:0009987,GO:0016787,GO:0016788,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 1MVM5@1224,2K2A5@204457,2TS4C@28211,COG0266@1,COG0266@2 NA|NA|NA L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates HIMHAPGP_00754 1522072.IL54_3710 1.3e-25 122.1 Sphingomonadales rpsT GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030234,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0042979,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050790,GO:0065003,GO:0065007,GO:0065009,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02968 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1MZ94@1224,2K617@204457,2UC42@28211,COG0268@1,COG0268@2 NA|NA|NA J Binds directly to 16S ribosomal RNA HIMHAPGP_00755 1346791.M529_15890 7.9e-51 206.8 Sphingomonadales Bacteria 1MWPC@1224,2K4FU@204457,2UK5M@28211,COG2070@1,COG2070@2 NA|NA|NA S 2-Nitropropane dioxygenase HIMHAPGP_00756 1219035.NT2_12_01210 1.7e-48 198.7 Sphingomonadales can 4.2.1.1 ko:K01673 ko00910,map00910 R00132,R10092 RC02807 ko00000,ko00001,ko01000 iNJ661.Rv3273 Bacteria 1NGFN@1224,2K2D9@204457,2TRPD@28211,COG0288@1,COG0288@2 NA|NA|NA P Reversible hydration of carbon dioxide HIMHAPGP_00757 392499.Swit_5337 1.8e-45 188.7 Sphingomonadales rnk ko:K03624,ko:K06140 ko00000,ko03000,ko03021 Bacteria 1MZNY@1224,2K5M6@204457,2UC6B@28211,COG0782@1,COG0782@2 NA|NA|NA J Transcription elongation factor, GreA/GreB, C-term HIMHAPGP_00758 1030157.AFMP01000019_gene588 6.6e-192 676.8 Sphingomonadales gdhA GO:0003674,GO:0003824,GO:0004353,GO:0004354,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.2,1.4.1.3,1.4.1.4 ko:K00260,ko:K00261,ko:K00262 ko00220,ko00250,ko00430,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00430,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 iJN678.gdhA Bacteria 1MUMF@1224,2K25I@204457,2TSZY@28211,COG0334@1,COG0334@2 NA|NA|NA E Belongs to the Glu Leu Phe Val dehydrogenases family HIMHAPGP_00759 882082.SaccyDRAFT_1574 1.3e-61 243.0 Pseudonocardiales 2.1.1.104 ko:K00588 ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110 M00039,M00350 R01942,R06578 RC00003,RC00392 ko00000,ko00001,ko00002,ko01000 Bacteria 2GP7A@201174,4E2Z2@85010,COG4122@1,COG4122@2 NA|NA|NA S PFAM O-methyltransferase HIMHAPGP_00760 1123240.ATVO01000003_gene252 2.6e-50 205.7 Sphingomonadales Bacteria 1QUPQ@1224,2K0RT@204457,2TW3M@28211,COG1051@1,COG1051@2 NA|NA|NA F COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes HIMHAPGP_00761 1114964.L485_17050 1.1e-68 266.9 Sphingomonadales tesB ko:K10805 ko01040,map01040 ko00000,ko00001,ko01000,ko01004 Bacteria 1MV9R@1224,2K289@204457,2TRFD@28211,COG1946@1,COG1946@2 NA|NA|NA I Acyl-CoA thioesterase HIMHAPGP_00762 1042375.AFPL01000046_gene2013 2.5e-09 68.2 Alteromonadaceae yggU ko:K09131 ko00000 Bacteria 1MZ4E@1224,1S9AB@1236,468EX@72275,COG1872@1,COG1872@2 NA|NA|NA S DUF167 HIMHAPGP_00763 983920.Y88_2089 3.4e-15 87.0 Sphingomonadales MA20_03740 Bacteria 1NG9U@1224,2K6XC@204457,2UFXJ@28211,COG5481@1,COG5481@2 NA|NA|NA S Protein of unknown function (DUF465) HIMHAPGP_00764 1090318.ATTI01000001_gene2104 9.5e-08 62.0 Sphingomonadales Bacteria 1NGRE@1224,2K7RY@204457,2UJAX@28211,COG5570@1,COG5570@2 NA|NA|NA S Protein of unknown function (DUF465) HIMHAPGP_00765 1248916.ANFY01000008_gene2081 2.5e-47 194.9 Sphingomonadales dksA ko:K06204 ko02026,map02026 ko00000,ko00001,ko03000,ko03009,ko03021 Bacteria 1RD08@1224,2K4GE@204457,2U74V@28211,COG1734@1,COG1734@2 NA|NA|NA T Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters HIMHAPGP_00766 392499.Swit_0096 1.7e-56 226.5 Sphingomonadales ykfC 3.4.14.13 ko:K20742,ko:K21471 ko00000,ko01000,ko01002,ko01011 Bacteria 1MW03@1224,2K27W@204457,2TSFG@28211,COG0791@1,COG0791@2 NA|NA|NA M NlpC/P60 family HIMHAPGP_00767 1522072.IL54_0164 3.1e-134 485.3 Sphingomonadales pepA 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 Bacteria 1MUIN@1224,2JZV7@204457,2TSI6@28211,COG0260@1,COG0260@2 NA|NA|NA E Belongs to the peptidase M17 family HIMHAPGP_00768 745310.G432_13715 2.2e-56 224.9 Sphingomonadales hemB GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1MWMW@1224,2K011@204457,2TS3F@28211,COG0113@1,COG0113@2 NA|NA|NA H Belongs to the ALAD family HIMHAPGP_00769 1144305.PMI02_00695 7.4e-194 684.1 Sphingomonadales Bacteria 1MVFB@1224,2KEFU@204457,2U0N7@28211,COG1629@1,COG4771@2 NA|NA|NA P TonB-dependent receptor plug HIMHAPGP_00770 745310.G432_15820 4e-164 584.7 Sphingomonadales abgB ko:K12941 ko00000,ko01002 Bacteria 1MX6N@1224,2KDGW@204457,2TRSE@28211,COG1473@1,COG1473@2 NA|NA|NA S amidohydrolase HIMHAPGP_00771 391937.NA2_10253 6.3e-25 121.3 Bacteria Bacteria COG0346@1,COG0346@2 NA|NA|NA E lactoylglutathione lyase activity HIMHAPGP_00772 113395.AXAI01000035_gene43 3.2e-30 138.7 Bradyrhizobiaceae 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 Bacteria 1MV92@1224,2TTXG@28211,3JVJZ@41294,COG3119@1,COG3119@2 NA|NA|NA P Sulfatase HIMHAPGP_00773 194867.ALBQ01000011_gene155 1.8e-140 505.4 Sphingomonadales mmsA 1.2.1.18,1.2.1.27 ko:K00140 ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200 M00013 R00705,R00706,R00922,R00935 RC00004,RC02723,RC02817 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUHV@1224,2K04G@204457,2TSMD@28211,COG1012@1,COG1012@2 NA|NA|NA C Methylmalonate-semialdehyde dehydrogenase HIMHAPGP_00774 1090319.KE386571_gene1764 4e-107 394.4 Sphingomonadales echA8 GO:0003674,GO:0003824,GO:0004300,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0030312,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 Bacteria 1MWZC@1224,2K12I@204457,2TRYS@28211,COG1024@1,COG1024@2 NA|NA|NA I Belongs to the enoyl-CoA hydratase isomerase family HIMHAPGP_00775 1174684.EBMC1_04649 5.8e-102 377.5 Sphingomonadales mmsB 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 R05066 RC00099 ko00000,ko00001,ko01000 Bacteria 1RA7F@1224,2K1F0@204457,2UVAZ@28211,COG2084@1,COG2084@2 NA|NA|NA I Belongs to the 3-hydroxyisobutyrate dehydrogenase family HIMHAPGP_00776 517722.AEUE01000002_gene2029 2.2e-51 209.9 Bacteria Bacteria 2F8FF@1,340U6@2 NA|NA|NA HIMHAPGP_00777 1470591.BW41_02758 3.6e-149 534.6 Sphingomonadales ino1 GO:0003674,GO:0003824,GO:0004512,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009405,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016853,GO:0016872,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659 5.5.1.4 ko:K01858 ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130 R07324 RC01804 ko00000,ko00001,ko01000 Bacteria 1N0D9@1224,2K1V4@204457,2TSH8@28211,COG1260@1,COG1260@2 NA|NA|NA I Inositol-3-phosphate synthase HIMHAPGP_00778 335543.Sfum_2923 1.3e-25 124.4 Deltaproteobacteria spsI GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0016780 2.7.7.74,2.7.8.34 ko:K07281,ko:K07291 ko00562,map00562 R09669,R09670 RC00002,RC00078 ko00000,ko00001,ko01000 Bacteria 1MYE7@1224,2WXQ5@28221,43F1I@68525,COG0558@1,COG0558@2 NA|NA|NA I Belongs to the CDP-alcohol phosphatidyltransferase class-I family HIMHAPGP_00779 272568.GDI0630 7e-38 164.5 Alphaproteobacteria Bacteria 1N5KT@1224,2UEHB@28211,COG0558@1,COG0558@2 NA|NA|NA I CDP-alcohol phosphatidyltransferase HIMHAPGP_00780 629773.AORY01000011_gene1836 4.4e-28 133.3 Sphingomonadales Bacteria 1MVEP@1224,2K0N2@204457,2TR50@28211,COG1196@1,COG1196@2 NA|NA|NA D nuclear chromosome segregation HIMHAPGP_00781 1248916.ANFY01000018_gene1577 1.7e-18 98.6 Sphingomonadales MA20_37275 Bacteria 1N8U9@1224,2K711@204457,2UGCD@28211,COG5454@1,COG5454@2 NA|NA|NA S Protein of unknown function (DUF1467) HIMHAPGP_00782 1123240.ATVO01000006_gene1310 5e-224 783.9 Sphingomonadales rnj GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004527,GO:0004532,GO:0004534,GO:0004540,GO:0005488,GO:0005515,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008409,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042802,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0090503,GO:0140098,GO:1901360 ko:K12574 ko03018,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 1MUGV@1224,2K04C@204457,2TQTR@28211,COG0595@1,COG0595@2 NA|NA|NA S metallo-beta-lactamase HIMHAPGP_00783 1248916.ANFY01000018_gene1579 1e-97 363.2 Sphingomonadales coaX GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1986 Bacteria 1MUYA@1224,2K0SW@204457,2TS5A@28211,COG1521@1,COG1521@2 NA|NA|NA F Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis HIMHAPGP_00784 1007104.SUS17_848 2.7e-42 178.7 Sphingomonadales birA 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 Bacteria 1MWCC@1224,2JZZZ@204457,2TS82@28211,COG0340@1,COG0340@2 NA|NA|NA H biotin lipoate A B protein ligase HIMHAPGP_00785 1234595.C725_0210 1.3e-135 490.0 unclassified Alphaproteobacteria nuoN GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 1MV56@1224,2TQMX@28211,4BPBD@82117,COG1007@1,COG1007@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient HIMHAPGP_00786 1219035.NT2_02_00340 5.4e-188 664.1 Sphingomonadales nuoM GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 1MV7V@1224,2K0EQ@204457,2TSNK@28211,COG1008@1,COG1008@2 NA|NA|NA C NADH ubiquinone oxidoreductase subunit HIMHAPGP_00787 1219035.NT2_02_00350 8.5e-124 450.3 Sphingomonadales nuoL 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 1MW2M@1224,2K1DM@204457,2TQSS@28211,COG1009@1,COG1009@2 NA|NA|NA CP NADH ubiquinone oxidoreductase subunit HIMHAPGP_00788 237727.NAP1_14348 8.3e-71 274.2 Proteobacteria Bacteria 1P3MU@1224,2DXS1@1,32V40@2 NA|NA|NA HIMHAPGP_00789 1123240.ATVO01000004_gene1035 2.8e-98 365.5 Sphingomonadales recF GO:0000731,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576 ko:K03629,ko:K07459 ko03440,map03440 ko00000,ko00001,ko03400 Bacteria 1MX8N@1224,2K0WV@204457,2TQRD@28211,COG1195@1,COG1195@2 NA|NA|NA L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP HIMHAPGP_00790 1234595.C725_0827 1.6e-19 102.1 Proteobacteria yggT GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02221 ko00000,ko02044 Bacteria 1N73Q@1224,COG0762@1,COG0762@2 NA|NA|NA S integral membrane protein HIMHAPGP_00791 1112212.JH584235_gene2073 1.6e-101 375.9 Sphingomonadales folD GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 Bacteria 1MWU4@1224,2K03K@204457,2TRZZ@28211,COG0190@1,COG0190@2 NA|NA|NA F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate HIMHAPGP_00792 1144307.PMI04_02998 8.9e-57 226.9 Sphingomonadales marC ko:K05595 ko00000,ko02000 2.A.95.1 Bacteria 1MX5T@1224,2K0G8@204457,2U59A@28211,COG2095@1,COG2095@2 NA|NA|NA U UPF0056 membrane protein HIMHAPGP_00793 1123240.ATVO01000005_gene1763 2.1e-41 176.0 Sphingomonadales Bacteria 1Q33M@1224,2E96M@1,2KAD7@204457,2V69S@28211,333F7@2 NA|NA|NA S PEP-CTERM motif HIMHAPGP_00794 314265.R2601_13514 2.1e-37 164.1 Alphaproteobacteria Bacteria 1RD7R@1224,2A5G6@1,2U8Y0@28211,30U67@2 NA|NA|NA HIMHAPGP_00795 745310.G432_08305 2.3e-31 141.4 Sphingomonadales ispG GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009055,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0022900,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046429,GO:0046490,GO:0046872,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 iAF1260.b2515,iAPECO1_1312.APECO1_4009,iB21_1397.B21_02369,iBWG_1329.BWG_2279,iE2348C_1286.E2348C_2798,iEC55989_1330.EC55989_2800,iECABU_c1320.ECABU_c28200,iECBD_1354.ECBD_1171,iECB_1328.ECB_02407,iECDH10B_1368.ECDH10B_2681,iECDH1ME8569_1439.ECDH1ME8569_2442,iECDH1ME8569_1439.EcDH1_1153,iECD_1391.ECD_02407,iECED1_1282.ECED1_2946,iECH74115_1262.ECH74115_3740,iECIAI39_1322.ECIAI39_2716,iECNA114_1301.ECNA114_2593,iECO103_1326.ECO103_3032,iECO111_1330.ECO111_3239,iECO26_1355.ECO26_3562,iECOK1_1307.ECOK1_2863,iECP_1309.ECP_2520,iECS88_1305.ECS88_2691,iECSE_1348.ECSE_2801,iECSF_1327.ECSF_2359,iECSP_1301.ECSP_3455,iECW_1372.ECW_m2740,iECs_1301.ECs3377,iEKO11_1354.EKO11_1218,iETEC_1333.ETEC_2672,iEcDH1_1363.EcDH1_1153,iEcE24377_1341.EcE24377A_2799,iEcolC_1368.EcolC_1162,iHN637.CLJU_RS06430,iIT341.HP0625,iJN678.gcpE,iJO1366.b2515,iJR904.b2515,iLF82_1304.LF82_1130,iNRG857_1313.NRG857_12515,iUMN146_1321.UM146_04130,iUMNK88_1353.UMNK88_3165,iUTI89_1310.UTI89_C2836,iWFL_1372.ECW_m2740,iY75_1357.Y75_RS13130,iYL1228.KPN_02845,iZ_1308.Z3778,ic_1306.c3037 Bacteria 1MUAX@1224,2K1FA@204457,2TQSI@28211,COG0821@1,COG0821@2 NA|NA|NA I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate HIMHAPGP_00796 685778.AORL01000025_gene119 3.1e-33 148.3 Sphingomonadales ats 2.3.1.57 ko:K00657 ko00330,ko01100,ko04216,map00330,map01100,map04216 M00135 R01154 RC00004,RC00096 ko00000,ko00001,ko00002,ko01000 Bacteria 1RCYQ@1224,2K4MG@204457,2TW76@28211,COG0454@1,COG0456@2 NA|NA|NA K Acetyltransferase (GNAT) domain HIMHAPGP_00797 1030157.AFMP01000004_gene1978 1.3e-150 539.7 Sphingomonadales hisS 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 1MV2K@1224,2K101@204457,2TSTH@28211,COG0124@1,COG0124@2 NA|NA|NA J histidyl-tRNA synthetase HIMHAPGP_00798 1030157.AFMP01000004_gene1979 3.1e-142 511.5 Sphingomonadales prfA ko:K02835 ko00000,ko03012 Bacteria 1MV28@1224,2K1M6@204457,2TQSV@28211,COG0216@1,COG0216@2 NA|NA|NA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA HIMHAPGP_00799 392499.Swit_2529 5.7e-75 287.7 Sphingomonadales prmC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.1.1.297,2.1.1.4 ko:K00543,ko:K02493,ko:K15256 ko00380,ko01100,map00380,map01100 M00037 R03130,R04905,R10806 RC00003,RC00392,RC03279 ko00000,ko00001,ko00002,ko01000,ko03012,ko03016 Bacteria 1MXCQ@1224,2K12S@204457,2TZFK@28211,COG2890@1,COG2890@2 NA|NA|NA J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif HIMHAPGP_00800 392499.Swit_2528 1e-18 100.5 Sphingomonadales Otg1 Bacteria 1N7JV@1224,2K53N@204457,2TR7A@28211,COG5373@1,COG5373@2 NA|NA|NA S Domain of unknown function (DUF4167) HIMHAPGP_00802 1449076.JOOE01000004_gene624 4.4e-31 141.0 Sphingomonadales MA20_31615 Bacteria 1N0H3@1224,2K5EC@204457,2UC0F@28211,COG0517@1,COG0517@2 NA|NA|NA S CBS domain HIMHAPGP_00803 627192.SLG_16840 1.1e-72 280.0 Alphaproteobacteria Bacteria 1RJJ8@1224,2CGCV@1,2USHC@28211,31JER@2 NA|NA|NA S Thrombospondin C-terminal region HIMHAPGP_00804 1282360.ABAC460_01350 2.8e-54 218.4 Caulobacterales ko:K02405 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 ko00000,ko00001,ko02035,ko03021 Bacteria 1RH1M@1224,2KJK6@204458,2V91A@28211,COG1595@1,COG1595@2 NA|NA|NA K ECF sigma factor HIMHAPGP_00805 715226.ABI_10370 1.5e-152 547.0 Alphaproteobacteria Bacteria 1MVEU@1224,2VEV6@28211,COG0515@1,COG0515@2 NA|NA|NA KLT serine threonine protein kinase HIMHAPGP_00806 1120705.FG95_00701 5e-235 820.8 Sphingomonadales ko:K02014 ko00000,ko02000 1.B.14 Bacteria 1MWKN@1224,2KEMN@204457,2TYFI@28211,COG1629@1,COG4771@2 NA|NA|NA P TonB dependent receptor HIMHAPGP_00807 1537715.JQFJ01000005_gene44 1.3e-50 206.1 Sphingomonadales Bacteria 1RDGK@1224,2K80G@204457,2U9DY@28211,COG1846@1,COG1846@2 NA|NA|NA K helix_turn_helix multiple antibiotic resistance protein HIMHAPGP_00808 1502850.FG91_02793 1.7e-188 665.6 Sphingomonadales leuC 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1MVYR@1224,2K0IM@204457,2TR6K@28211,COG0065@1,COG0065@2 NA|NA|NA E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate HIMHAPGP_00809 1537715.JQFJ01000005_gene45 2.2e-49 202.2 Sphingomonadales leuD 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1MVXB@1224,2JZWQ@204457,2TRRS@28211,COG0066@1,COG0066@2 NA|NA|NA E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate HIMHAPGP_00810 928724.SacglDRAFT_02379 4.7e-55 221.5 Pseudonocardiales mhpD 4.1.1.77,4.2.1.80 ko:K01617,ko:K02554 ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220 M00545,M00569 R02601,R02602,R04781,R05374 RC00750,RC00751,RC01213,RC02672 br01602,ko00000,ko00001,ko00002,ko01000 Bacteria 2GPBI@201174,4E416@85010,COG3971@1,COG3971@2 NA|NA|NA Q Fumarylacetoacetate (FAA) hydrolase family HIMHAPGP_00811 1174684.EBMC1_14560 1.9e-190 671.8 Sphingomonadales Bacteria 1NX52@1224,2K13I@204457,2TSJM@28211,COG1073@1,COG1073@2 NA|NA|NA I Alpha beta hydrolase HIMHAPGP_00812 1174684.EBMC1_14565 4.3e-85 321.6 Sphingomonadales Bacteria 1QYXT@1224,2KA53@204457,2TY11@28211,COG3173@1,COG3173@2 NA|NA|NA S Phosphotransferase enzyme family HIMHAPGP_00813 1537715.JQFJ01000005_gene38 1.5e-175 622.5 Sphingomonadales eno 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 Bacteria 1MU1N@1224,2K00W@204457,2TR04@28211,COG0148@1,COG0148@2 NA|NA|NA G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis HIMHAPGP_00814 1174684.EBMC1_14575 4.3e-87 328.2 Sphingomonadales serA3 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1MU2D@1224,2KAPY@204457,2TVKE@28211,COG1052@1,COG1052@2 NA|NA|NA CH D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain HIMHAPGP_00815 1502850.FG91_02803 3.5e-70 271.6 Sphingomonadales Bacteria 1QUZX@1224,2K4WA@204457,2TWE4@28211,COG2267@1,COG2267@2 NA|NA|NA I Alpha/beta hydrolase family HIMHAPGP_00816 1123240.ATVO01000010_gene618 2.4e-52 212.6 Sphingomonadales Bacteria 1N8UK@1224,2KE88@204457,2U35V@28211,COG2267@1,COG2267@2 NA|NA|NA I Alpha/beta hydrolase family HIMHAPGP_00817 1282362.AEAC466_14710 2.3e-135 488.8 Caulobacterales potA 3.6.3.31 ko:K11072,ko:K11076 ko02010,map02010 M00299,M00300 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.11.1,3.A.1.11.2 Bacteria 1MU3I@1224,2KG68@204458,2TQMJ@28211,COG3842@1,COG3842@2 NA|NA|NA P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system HIMHAPGP_00818 509190.Cseg_0819 9.3e-102 376.7 Caulobacterales potC ko:K11070 ko02010,map02010 M00299 ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 Bacteria 1MVC5@1224,2KGW4@204458,2TRRJ@28211,COG1177@1,COG1177@2 NA|NA|NA P Spermidine putrescine ABC transporter, permease HIMHAPGP_00819 1449049.JONW01000005_gene1021 6.9e-100 370.5 Caulobacterales ko:K11071 ko02010,map02010 M00299 ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 Bacteria 1MVGM@1224,2KGT2@204458,2TSFD@28211,COG1176@1,COG1176@2 NA|NA|NA P PFAM binding-protein-dependent transport systems inner membrane component HIMHAPGP_00820 1292034.OR37_02738 2.1e-133 482.3 Caulobacterales ko:K11069 ko02010,map02010 M00299 ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 Bacteria 1MUYW@1224,2KHP0@204458,2TSUZ@28211,COG0687@1,COG0687@2 NA|NA|NA E Required for the activity of the bacterial periplasmic transport system of putrescine HIMHAPGP_00821 1234595.C725_0686 2.3e-57 229.2 Alphaproteobacteria Bacteria 1PWCZ@1224,2U4MM@28211,COG2267@1,COG2267@2 NA|NA|NA I Alpha/beta hydrolase family HIMHAPGP_00822 1219049.SP5_102_00330 8.2e-310 1069.3 Sphingomonadales maeB 1.1.1.38,1.1.1.40,2.3.1.8 ko:K00027,ko:K00029,ko:K00625,ko:K13788 ko00430,ko00620,ko00640,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,ko02020,map00430,map00620,map00640,map00680,map00710,map00720,map01100,map01120,map01200,map02020 M00169,M00172,M00357,M00579 R00214,R00216,R00230,R00921 RC00004,RC00105,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1637 Bacteria 1MU0A@1224,2JZY4@204457,2TQJT@28211,COG0280@1,COG0280@2,COG0281@1,COG0281@2 NA|NA|NA C Malic enzyme HIMHAPGP_00823 1123269.NX02_23180 1.8e-236 825.9 Sphingomonadales mutS GO:0000018,GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0008301,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030554,GO:0030983,GO:0031323,GO:0032136,GO:0032300,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1990391 ko:K03555 ko03430,map03430 ko00000,ko00001,ko03400 iECW_1372.ECW_m2935,iWFL_1372.ECW_m2935 Bacteria 1MUGX@1224,2K09S@204457,2TQRR@28211,COG0249@1,COG0249@2 NA|NA|NA L that it carries out the mismatch recognition step. This protein has a weak ATPase activity HIMHAPGP_00824 627192.SLG_38490 1.1e-73 283.9 Sphingomonadales ycbB GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0006508,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0008236,GO:0008238,GO:0009273,GO:0009987,GO:0016740,GO:0016746,GO:0016755,GO:0016787,GO:0016807,GO:0017171,GO:0019538,GO:0033554,GO:0042546,GO:0043164,GO:0043170,GO:0044036,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0050896,GO:0051716,GO:0070004,GO:0070008,GO:0070011,GO:0071554,GO:0071704,GO:0071840,GO:0071972,GO:0140096,GO:1901564 ko:K21470 ko00000,ko01002,ko01011 Bacteria 1MV14@1224,2K0KA@204457,2TRJ9@28211,COG2989@1,COG2989@2 NA|NA|NA S protein conserved in bacteria HIMHAPGP_00825 392499.Swit_1362 3.5e-50 204.9 Sphingomonadales FN0914 Bacteria 1RKB2@1224,2K4DR@204457,2UAA8@28211,COG1376@1,COG1376@2 NA|NA|NA S L,D-transpeptidase catalytic domain HIMHAPGP_00826 314266.SKA58_11408 1.7e-64 252.7 Sphingomonadales ko:K07454 ko00000 Bacteria 1NE0N@1224,2K0ZJ@204457,2TV2B@28211,COG3440@1,COG3440@2 NA|NA|NA V HNH endonuclease HIMHAPGP_00827 392499.Swit_2138 2.7e-143 515.0 Sphingomonadales ruvB 3.6.4.12 ko:K03551,ko:K07126 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 1MU38@1224,2K0Y3@204457,2TQNG@28211,COG2255@1,COG2255@2 NA|NA|NA L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing HIMHAPGP_00828 745310.G432_11970 1.5e-99 369.8 Sphingomonadales 3.4.13.19 ko:K01273 ko00000,ko00537,ko01000,ko01002,ko04147 Bacteria 1MWEW@1224,2K0GT@204457,2TR5C@28211,COG2355@1,COG2355@2 NA|NA|NA E Zn-dependent dipeptidase, microsomal dipeptidase HIMHAPGP_00829 426114.THI_2856 3.9e-39 167.9 unclassified Burkholderiales ytfE GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0018282,GO:0018283,GO:0019538,GO:0022607,GO:0030091,GO:0031163,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0071704,GO:0071840,GO:1901564 ko:K07322 ko00000 iECED1_1282.ECED1_5068,iECH74115_1262.ECH74115_5726,iECSP_1301.ECSP_5311,iECs_1301.ECs5187,iG2583_1286.G2583_5039,iZ_1308.Z5820 Bacteria 1KMV8@119065,1MVCQ@1224,2VJ5Z@28216,COG2846@1,COG2846@2 NA|NA|NA D Di-iron-containing protein involved in the repair of iron-sulfur clusters HIMHAPGP_00830 1248916.ANFY01000010_gene325 1.9e-173 615.5 Sphingomonadales hslU GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019904,GO:0022607,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043335,GO:0043933,GO:0044085,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1904949,GO:1905368,GO:1905369 ko:K03667 ko00000,ko03110 Bacteria 1MVK9@1224,2K0UP@204457,2TRXC@28211,COG1220@1,COG1220@2 NA|NA|NA O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis HIMHAPGP_00831 666684.AfiDRAFT_1533 5e-72 277.3 Bradyrhizobiaceae hslV GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016787,GO:0017076,GO:0019538,GO:0019904,GO:0022607,GO:0030163,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0051603,GO:0065003,GO:0070003,GO:0070011,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 3.4.25.2 ko:K01419 ko00000,ko01000,ko01002 Bacteria 1MVF2@1224,2TRRE@28211,3JRD8@41294,COG5405@1,COG5405@2 NA|NA|NA O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery HIMHAPGP_00832 1234595.C725_1767 8.5e-74 284.3 unclassified Alphaproteobacteria Bacteria 1N4JN@1224,2UE2X@28211,4BSNT@82117,COG4872@1,COG4872@2 NA|NA|NA S Predicted membrane protein (DUF2157) HIMHAPGP_00833 1234595.C725_1768 5.9e-24 117.5 Alphaproteobacteria Bacteria 1NH9V@1224,2ERHA@1,2UJWK@28211,33J2S@2 NA|NA|NA S GDYXXLXY protein HIMHAPGP_00834 1248916.ANFY01000003_gene507 5.9e-112 411.4 Sphingomonadales Bacteria 1PDRG@1224,2K0P5@204457,2TVKM@28211,COG2244@1,COG2244@2 NA|NA|NA S Polysaccharide biosynthesis protein HIMHAPGP_00835 1449049.JONW01000013_gene4762 7.2e-88 331.3 Caulobacterales ko:K03292 ko00000 2.A.2 Bacteria 1MVUM@1224,2KFG7@204458,2U1DI@28211,COG2211@1,COG2211@2 NA|NA|NA G PFAM major facilitator superfamily MFS_1 HIMHAPGP_00836 1550073.JROH01000009_gene1369 2.7e-187 661.8 Sphingomonadales aldH 1.2.1.26 ko:K13877 ko00040,ko00053,map00040,map00053 R00264 RC00080 ko00000,ko00001,ko01000 Bacteria 1MY2V@1224,2K0M1@204457,2TTPR@28211,COG1012@1,COG1012@2 NA|NA|NA C Dehydrogenase HIMHAPGP_00838 1123240.ATVO01000007_gene2176 0.0 1579.3 Sphingomonadales MA20_35585 1.2.7.11,1.2.7.3,1.2.7.8 ko:K00175,ko:K04090 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1MUKS@1224,2K2DM@204457,2TSHH@28211,COG1014@1,COG1014@2,COG4231@1,COG4231@2 NA|NA|NA C PFAM pyruvate ferredoxin flavodoxin oxidoreductase HIMHAPGP_00840 1234595.C725_0598 5.4e-110 404.4 Alphaproteobacteria Bacteria 1N05C@1224,2TT9T@28211,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase HIMHAPGP_00841 1248916.ANFY01000007_gene2591 4.1e-175 620.9 Sphingomonadales Bacteria 1MVJC@1224,2K4UJ@204457,2TTRD@28211,COG1960@1,COG1960@2 NA|NA|NA C overlaps another CDS with the same product name HIMHAPGP_00842 1549858.MC45_02375 5.6e-87 327.8 Sphingomonadales yfeH ko:K14347 ko00000,ko02000,ko04147 2.A.93.1 Bacteria 1MUMM@1224,2K0HH@204457,2TU7J@28211,COG0385@1,COG0385@2 NA|NA|NA S Bile acid sodium symporter HIMHAPGP_00843 1121123.AUAO01000002_gene470 3.7e-100 371.7 Caulobacterales selU GO:0001887,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016785,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043828,GO:0044237,GO:0044238,GO:0046483,GO:0070329,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 ko:K06917 ko00000,ko01000,ko03016 Bacteria 1N4T5@1224,2KHTI@204458,2TS2E@28211,COG2603@1,COG2603@2 NA|NA|NA H Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA HIMHAPGP_00844 450851.PHZ_c1183 6.2e-126 457.2 Caulobacterales selD 2.7.9.3 ko:K01008 ko00450,ko01100,map00450,map01100 R03595 RC00002,RC02878 ko00000,ko00001,ko01000,ko03016 Bacteria 1MWFG@1224,2KFVK@204458,2TR91@28211,COG0709@1,COG0709@2 NA|NA|NA E AIR synthase related protein, C-terminal domain HIMHAPGP_00845 1248916.ANFY01000003_gene617 5.1e-107 394.4 Sphingomonadales pfkB 2.7.1.4 ko:K00847 ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100 R00760,R00867,R03920 RC00002,RC00017 ko00000,ko00001,ko01000 Bacteria 1MUUC@1224,2K0DX@204457,2TS9D@28211,COG0524@1,COG0524@2 NA|NA|NA G Carbohydrate kinase HIMHAPGP_00846 1174684.EBMC1_06499 4.5e-12 77.8 Sphingomonadales Bacteria 1NGHW@1224,2EHHR@1,2K6SJ@204457,2UJVS@28211,33B9P@2 NA|NA|NA HIMHAPGP_00847 1123240.ATVO01000009_gene816 9.8e-135 486.9 Sphingomonadales hisD GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23,1.1.1.308 ko:K00013,ko:K15509 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 iYO844.BSU34910 Bacteria 1MUUF@1224,2K0A0@204457,2TSBN@28211,COG0141@1,COG0141@2 NA|NA|NA E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine HIMHAPGP_00848 1379701.JPJC01000226_gene2011 3.1e-76 291.6 Sphingomonadales hisG GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 ko:K00765,ko:K02502 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUCY@1224,2K1K3@204457,2TT0H@28211,COG0040@1,COG0040@2 NA|NA|NA E Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity HIMHAPGP_00849 1219045.BV98_000323 3.3e-42 178.3 Sphingomonadales rimP GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576 ko:K09748 ko00000,ko03009 Bacteria 1RDP2@1224,2K45N@204457,2TS4E@28211,COG0779@1,COG0779@2 NA|NA|NA S Required for maturation of 30S ribosomal subunits HIMHAPGP_00850 627192.SLG_29160 5.2e-174 617.5 Sphingomonadales cznA ko:K07787,ko:K15726 ko02020,map02020 ko00000,ko00001,ko02000 2.A.6.1.2,2.A.6.1.4 Bacteria 1NUIV@1224,2K0B8@204457,2TRWM@28211,COG3696@1,COG3696@2 NA|NA|NA P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family HIMHAPGP_00851 1331060.RLDS_00280 3.9e-18 97.4 Sphingomonadales Bacteria 1NVZC@1224,2AJX7@1,2KDRT@204457,2URXA@28211,31AAD@2 NA|NA|NA S Protein of unknown function (DUF3240) HIMHAPGP_00852 392499.Swit_3710 1.8e-125 456.1 Sphingomonadales Bacteria 1R9PU@1224,2K2MD@204457,2U0WQ@28211,COG1538@1,COG1538@2 NA|NA|NA MU Outer membrane efflux protein HIMHAPGP_00853 1123360.thalar_02883 8.8e-10 68.9 Alphaproteobacteria Bacteria 1NNN9@1224,2ERCE@1,2UXY5@28211,33IY3@2 NA|NA|NA HIMHAPGP_00854 1123360.thalar_02884 1.7e-91 342.0 Alphaproteobacteria 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 Bacteria 1NZNI@1224,2UJSY@28211,COG1622@1,COG1622@2 NA|NA|NA C cytochrome c oxidase (Subunit II) HIMHAPGP_00856 639283.Snov_4348 5.1e-62 245.0 Alphaproteobacteria ko:K06400 ko00000 Bacteria 1MWCZ@1224,2TRIY@28211,COG1961@1,COG1961@2 NA|NA|NA L Resolvase HIMHAPGP_00858 1248916.ANFY01000017_gene1439 3.1e-107 395.2 Sphingomonadales mltB 5.1.3.15 ko:K00786,ko:K01792,ko:K08305 ko00010,ko01100,ko01110,ko01120,ko01130,map00010,map01100,map01110,map01120,map01130 R02739 RC00563 ko00000,ko00001,ko01000,ko01011 GH103 Bacteria 1MUZ3@1224,2K0TV@204457,2TRP0@28211,COG2951@1,COG2951@2 NA|NA|NA M Lytic murein transglycosylase HIMHAPGP_00859 1248916.ANFY01000017_gene1438 5.5e-57 228.0 Sphingomonadales rlpA GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 ko:K03642 ko00000 Bacteria 1MZ8S@1224,2K4AD@204457,2TUER@28211,COG0797@1,COG0797@2 NA|NA|NA M Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides HIMHAPGP_00860 1234595.C725_0477 6.8e-52 210.7 unclassified Alphaproteobacteria tmk GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 1MV9C@1224,2U72D@28211,4BQ9N@82117,COG0125@1,COG0125@2 NA|NA|NA F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis HIMHAPGP_00861 1123269.NX02_00960 6.3e-76 290.8 Sphingomonadales Bacteria 1NXAF@1224,2K0X1@204457,2TRF0@28211,COG3000@1,COG3000@2 NA|NA|NA I sterol desaturase HIMHAPGP_00862 1248916.ANFY01000011_gene1177 6.4e-104 384.4 Sphingomonadales crtL 5.5.1.18,5.5.1.19 ko:K06443,ko:K06444 ko00906,ko01100,ko01110,map00906,map01100,map01110 M00097 R03824,R04801,R05341,R06960,R06962,R06963,R07840,R07856 RC01004,RC01612,RC01964 ko00000,ko00001,ko00002,ko01000 Bacteria 1QVKV@1224,2KEPI@204457,2TWHU@28211,COG0644@1,COG0644@2 NA|NA|NA C Lycopene cyclase protein HIMHAPGP_00863 1248916.ANFY01000011_gene1176 1.6e-192 679.1 Sphingomonadales crtI 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 ko:K10027 ko00906,ko01100,ko01110,map00906,map01100,map01110 R04787,R04798,R04800,R09691,R09692 RC01214,RC02088,RC02605 ko00000,ko00001,ko01000 Bacteria 1MV2R@1224,2K17H@204457,2TSR0@28211,COG1233@1,COG1233@2 NA|NA|NA Q Phytoene dehydrogenase HIMHAPGP_00864 1248916.ANFY01000011_gene1175 1.2e-86 326.6 Sphingomonadales crtB GO:0003674,GO:0003824,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016108,GO:0016109,GO:0016114,GO:0016116,GO:0016117,GO:0016740,GO:0016765,GO:0042440,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046148,GO:0071704,GO:1901576 2.5.1.32,2.5.1.99 ko:K02291 ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110 M00097 R02065,R04218,R07270,R10177 RC00362,RC01101,RC02869 ko00000,ko00001,ko00002,ko01000,ko01006 Bacteria 1MX4W@1224,2K2BH@204457,2TTI0@28211,COG1562@1,COG1562@2 NA|NA|NA I Phytoene synthase HIMHAPGP_00865 1123269.NX02_21750 2.9e-48 198.4 Sphingomonadales crtZ 1.14.15.24 ko:K15746 ko00906,ko01100,ko01110,map00906,map01100,map01110 M00372 R07530,R07558,R07559,R07561,R07562,R07568,R07569,R07570,R07572,R07851,R09747 RC00478,RC00704,RC02629 ko00000,ko00001,ko00002,ko01000 Bacteria 1MYGK@1224,2KCDZ@204457,2UAP4@28211,COG3000@1,COG3000@2 NA|NA|NA I Fatty acid hydroxylase superfamily HIMHAPGP_00866 745310.G432_03920 1.2e-77 297.4 Sphingomonadales tolC ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 Bacteria 1MWCJ@1224,2JZY5@204457,2TR3S@28211,COG1538@1,COG1538@2 NA|NA|NA MU membrane HIMHAPGP_00867 629773.AORY01000012_gene808 5.8e-40 171.0 Sphingomonadales pcm 2.1.1.77 ko:K00573 ko00000,ko01000 Bacteria 1RD6S@1224,2K2P0@204457,2U704@28211,COG2518@1,COG2518@2 NA|NA|NA O protein-L-isoaspartate HIMHAPGP_00868 1030157.AFMP01000040_gene1623 6.5e-183 647.1 Sphingomonadales zwf GO:0003674,GO:0003824,GO:0004345,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007267,GO:0008150,GO:0008152,GO:0009117,GO:0009372,GO:0009987,GO:0010699,GO:0016491,GO:0016614,GO:0016616,GO:0019318,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0023052,GO:0034641,GO:0042802,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0051704,GO:0055086,GO:0055114,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 e_coli_core.b1852,iAF1260.b1852,iBWG_1329.BWG_1666,iE2348C_1286.E2348C_1977,iEC042_1314.EC042_2019,iECABU_c1320.ECABU_c21130,iECDH10B_1368.ECDH10B_1993,iECDH1ME8569_1439.ECDH1ME8569_1798,iECED1_1282.ECED1_2057,iECIAI39_1322.ECIAI39_1198,iECNA114_1301.ECNA114_1899,iECO26_1355.ECO26_2690,iECP_1309.ECP_1796,iECSF_1327.ECSF_1710,iECUMN_1333.ECUMN_2149,iECW_1372.ECW_m2026,iEKO11_1354.EKO11_1918,iEcDH1_1363.EcDH1_1789,iEcE24377_1341.EcE24377A_2082,iEcHS_1320.EcHS_A1944,iEcSMS35_1347.EcSMS35_1335,iEcolC_1368.EcolC_1780,iG2583_1286.G2583_2304,iJO1366.b1852,iJR904.b1852,iLF82_1304.LF82_3733,iNRG857_1313.NRG857_09280,iSDY_1059.SDY_1138,iWFL_1372.ECW_m2026,iY75_1357.Y75_RS09725,iYL1228.KPN_02367,ic_1306.c2265 Bacteria 1MUN0@1224,2K20G@204457,2TQXA@28211,COG0364@1,COG0364@2 NA|NA|NA G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone HIMHAPGP_00869 1121861.KB899930_gene233 9.7e-27 125.9 Rhodospirillales phhB 4.2.1.96 ko:K01724 ko00790,map00790 R04734 RC01208 ko00000,ko00001,ko01000,ko04147 Bacteria 1MZ5Q@1224,2JU2A@204441,2UBWN@28211,COG2154@1,COG2154@2 NA|NA|NA H pterin-4-alpha-carbinolamine dehydratase HIMHAPGP_00870 1123240.ATVO01000006_gene1481 2.3e-42 178.3 Sphingomonadales MA20_43655 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 Bacteria 1N18M@1224,2K6IY@204457,2UBUK@28211,COG3824@1,COG3824@2 NA|NA|NA S protein conserved in bacteria HIMHAPGP_00871 1550073.JROH01000045_gene2970 9.5e-133 480.3 Sphingomonadales hipO ko:K01436 ko00000,ko01000,ko01002 Bacteria 1MUIV@1224,2K0AI@204457,2TR5B@28211,COG1473@1,COG1473@2 NA|NA|NA S amidohydrolase HIMHAPGP_00872 1282876.BAOK01000002_gene516 3e-68 265.4 Alphaproteobacteria Bacteria 1R65D@1224,2U101@28211,COG1946@1,COG1946@2 NA|NA|NA I Thioesterase-like superfamily HIMHAPGP_00873 1122137.AQXF01000001_gene2847 3.5e-55 221.5 Alphaproteobacteria yvqK 2.5.1.17 ko:K00798 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 Bacteria 1RDUF@1224,2U5J1@28211,COG2096@1,COG2096@2 NA|NA|NA S adenosyltransferase HIMHAPGP_00875 745310.G432_08875 1.9e-73 282.7 Sphingomonadales gluQ 6.1.1.17 ko:K01885,ko:K01894 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 Bacteria 1MUN7@1224,2K0FZ@204457,2TR2V@28211,COG0008@1,COG0008@2 NA|NA|NA J Belongs to the class-I aminoacyl-tRNA synthetase family HIMHAPGP_00876 1030157.AFMP01000040_gene1574 9.8e-82 309.7 Sphingomonadales MA20_20605 Bacteria 1MWEQ@1224,2K04Q@204457,2TR3M@28211,COG1403@1,COG1403@2 NA|NA|NA L HNH endonuclease HIMHAPGP_00877 1123267.JONN01000001_gene934 8.9e-61 239.6 Sphingomonadales ndk GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 Bacteria 1R9ZA@1224,2K3WY@204457,2U5CS@28211,COG0105@1,COG0105@2 NA|NA|NA F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate HIMHAPGP_00880 1449076.JOOE01000004_gene508 1.7e-80 305.8 Sphingomonadales MA20_20925 ko:K09987 ko00000 Bacteria 1MVR2@1224,2K0D3@204457,2TT8Z@28211,COG3820@1,COG3820@2 NA|NA|NA S protein conserved in bacteria HIMHAPGP_00881 194867.ALBQ01000014_gene551 6.3e-31 141.0 Sphingomonadales thiE2 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 Bacteria 1MZ0K@1224,2KCXN@204457,2UA7U@28211,COG0352@1,COG0352@2 NA|NA|NA H Thiamine monophosphate synthase HIMHAPGP_00882 1219049.SP5_043_00200 8.7e-69 266.9 Sphingomonadales yggS GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 ko:K06997 ko00000 Bacteria 1MWN7@1224,2K0C6@204457,2TR5Z@28211,COG0325@1,COG0325@2 NA|NA|NA S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis HIMHAPGP_00884 460265.Mnod_5624 5e-11 73.2 Methylobacteriaceae Bacteria 1JXM3@119045,1RI65@1224,2UA0U@28211,COG4961@1,COG4961@2 NA|NA|NA U Putative Flp pilus-assembly TadE/G-like HIMHAPGP_00885 392499.Swit_0508 0.0 1198.0 Sphingomonadales alaS GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002161,GO:0002196,GO:0003674,GO:0003700,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006355,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009451,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:0140110,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iECABU_c1320.ECABU_c29670,iECED1_1282.ECED1_3146,iEcHS_1320.EcHS_A2833,iJN746.PP_4474 Bacteria 1MU9A@1224,2K28K@204457,2TQV4@28211,COG0013@1,COG0013@2 NA|NA|NA J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain HIMHAPGP_00886 1248916.ANFY01000009_gene240 1.2e-134 486.9 Sphingomonadales ppx 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 R03409 RC00002 ko00000,ko00001,ko01000 Bacteria 1MV35@1224,2JZYK@204457,2TR1W@28211,COG0248@1,COG0248@2 NA|NA|NA FP exopolyphosphatase HIMHAPGP_00887 1248916.ANFY01000009_gene239 1.6e-145 522.7 Sphingomonadales rnd 3.1.13.5 ko:K03684 ko00000,ko01000,ko03016 Bacteria 1MURV@1224,2K0ID@204457,2TSQM@28211,COG0349@1,COG0349@2 NA|NA|NA J Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides HIMHAPGP_00888 379731.PST_2812 2.3e-26 127.1 Proteobacteria Bacteria 1NXEM@1224,2B065@1,31SGV@2 NA|NA|NA HIMHAPGP_00889 1123240.ATVO01000007_gene2171 4.3e-85 320.9 Sphingomonadales pyrB GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 ko:K00608,ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 iYO844.BSU15490 Bacteria 1MWAB@1224,2K0IH@204457,2TRHP@28211,COG0540@1,COG0540@2 NA|NA|NA F Belongs to the ATCase OTCase family HIMHAPGP_00890 1030157.AFMP01000008_gene3169 5.2e-117 427.9 Sphingomonadales pyrC GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 Bacteria 1MVXY@1224,2K003@204457,2TSTM@28211,COG0044@1,COG0044@2 NA|NA|NA F dihydroorotase HIMHAPGP_00891 1207055.C100_10855 4.1e-36 159.1 Sphingomonadales ko:K07126 ko00000 Bacteria 1RJ71@1224,2K032@204457,2U15P@28211,COG0790@1,COG0790@2,COG3147@1,COG3147@2 NA|NA|NA S FOG TPR repeat, SEL1 subfamily HIMHAPGP_00892 1123240.ATVO01000005_gene1777 3.1e-22 110.9 Sphingomonadales yqjP Bacteria 1MUXF@1224,2K1NF@204457,2TSYY@28211,COG0491@1,COG0491@2 NA|NA|NA S Metallo-beta-lactamase superfamily HIMHAPGP_00893 1112214.AHIS01000046_gene2282 1.9e-25 122.1 Sphingomonadales spoT GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 iECNA114_1301.ECNA114_3794,iECOK1_1307.ECOK1_4092,iECP_1309.ECP_3748,iECS88_1305.ECS88_4065,iECSF_1327.ECSF_3486,iLF82_1304.LF82_2165,iNRG857_1313.NRG857_18145,iUMN146_1321.UM146_18405,iUTI89_1310.UTI89_C4195,ic_1306.c4475 Bacteria 1MU44@1224,2K15Q@204457,2TQNY@28211,COG0317@1,COG0317@2 NA|NA|NA KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance HIMHAPGP_00894 13690.CP98_02622 5e-150 537.7 Sphingomonadales cpg2_2 3.4.17.11 ko:K01295 ko00000,ko01000,ko01002 Bacteria 1MUSU@1224,2K14S@204457,2TTBP@28211,COG0624@1,COG0624@2 NA|NA|NA E peptidase M20 HIMHAPGP_00895 1123269.NX02_01350 1.6e-193 682.6 Sphingomonadales Bacteria 1MXZ3@1224,2K0UX@204457,2TSHC@28211,COG0477@1,COG0477@2 NA|NA|NA EGP Major facilitator superfamily HIMHAPGP_00896 1449076.JOOE01000001_gene2230 2.7e-210 738.0 Sphingomonadales atrC1 ko:K03294 ko00000 2.A.3.2 Bacteria 1MXNJ@1224,2K03C@204457,2TRNX@28211,COG0531@1,COG0531@2 NA|NA|NA E amino acid HIMHAPGP_00897 1449076.JOOE01000001_gene2231 8.3e-66 256.9 Sphingomonadales Bacteria 1RBC0@1224,2KDYA@204457,2U58C@28211,COG1802@1,COG1802@2 NA|NA|NA K FCD HIMHAPGP_00898 1470591.BW41_03231 2e-159 568.5 Sphingomonadales prpA GO:0003674,GO:0003824,GO:0006575,GO:0006577,GO:0006579,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0034641,GO:0036361,GO:0042219,GO:0044237,GO:0044248,GO:0044270,GO:0047580,GO:0047661,GO:0071704,GO:1901564,GO:1901565,GO:1901575 5.1.1.8 ko:K12658 ko00330,map00330 R03296 RC00479 ko00000,ko00001,ko01000 Bacteria 1NVF9@1224,2K233@204457,2TX8Z@28211,COG3938@1,COG3938@2 NA|NA|NA E Belongs to the proline racemase family HIMHAPGP_00899 1449076.JOOE01000001_gene2233 3.1e-135 488.0 Sphingomonadales dapA2 3.5.4.22,4.3.3.7 ko:K01714,ko:K21062 ko00261,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map00330,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R02280,R10147 RC00679,RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 Bacteria 1MXI1@1224,2K2AG@204457,2TTWT@28211,COG0329@1,COG0329@2 NA|NA|NA EM Belongs to the DapA family HIMHAPGP_00900 1549858.MC45_12605 8.9e-133 480.3 Sphingomonadales dadA 1.4.5.1 ko:K00285,ko:K21060 ko00330,ko00360,map00330,map00360 R01374,R09493,R11428 RC00006,RC00025,RC00135 ko00000,ko00001,ko01000 Bacteria 1MVIZ@1224,2K19D@204457,2TSQI@28211,COG0665@1,COG0665@2 NA|NA|NA E FAD dependent oxidoreductase HIMHAPGP_00901 1449076.JOOE01000001_gene2235 1.5e-166 592.4 Sphingomonadales pepQ_2 3.4.13.9 ko:K01271 ko00000,ko01000,ko01002 Bacteria 1MUZS@1224,2K0GN@204457,2TRQ5@28211,COG0006@1,COG0006@2 NA|NA|NA E Belongs to the peptidase M24B family HIMHAPGP_00902 745310.G432_16425 7.3e-58 231.1 Sphingomonadales tilS 6.3.4.19 ko:K04075 R09597 RC02633,RC02634 ko00000,ko01000,ko03016 Bacteria 1MU85@1224,2K3YA@204457,2TRK1@28211,COG0037@1,COG0037@2 NA|NA|NA D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine HIMHAPGP_00903 1123240.ATVO01000004_gene1233 1.4e-210 739.2 Sphingomonadales nadE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5,6.3.5.1 ko:K01916,ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00189,R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 Bacteria 1MU9U@1224,2K0R3@204457,2TRAU@28211,COG0171@1,COG0171@2,COG0388@1,COG0388@2 NA|NA|NA H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source HIMHAPGP_00904 1248916.ANFY01000010_gene329 2e-225 788.5 Sphingomonadales Bacteria 1PS8Y@1224,2K1H5@204457,2TQUK@28211,COG1228@1,COG1228@2 NA|NA|NA Q Amidohydrolase family HIMHAPGP_00905 1122604.JONR01000014_gene203 5.8e-66 258.5 Xanthomonadales Bacteria 1MWTW@1224,1S3FP@1236,1XAHZ@135614,COG5361@1,COG5361@2 NA|NA|NA S Protein of unknown function (DUF1254) HIMHAPGP_00906 1248916.ANFY01000011_gene1102 1e-154 553.1 Sphingomonadales MA20_06750 2.3.1.16,2.3.1.9 ko:K00626,ko:K00632 ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00087,M00088,M00095,M00113,M00373,M00374,M00375 R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1MU5G@1224,2K081@204457,2TSA0@28211,COG0183@1,COG0183@2 NA|NA|NA I Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation HIMHAPGP_00907 402881.Plav_0849 5.4e-119 434.1 Alphaproteobacteria 5.3.3.18 ko:K15866 ko00360,ko01120,map00360,map01120 R09837,R09839 RC00004,RC00326,RC02689,RC03003 ko00000,ko00001,ko01000 Bacteria 1MVPQ@1224,2TTJ4@28211,COG1024@1,COG1024@2 NA|NA|NA I Enoyl-CoA hydratase HIMHAPGP_00908 190650.CC_3308 1.5e-73 283.1 Caulobacterales ko:K01998 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 1R9GQ@1224,2KGD4@204458,2U3YF@28211,COG2267@1,COG2267@2 NA|NA|NA I PFAM alpha beta hydrolase HIMHAPGP_00909 1292034.OR37_02779 6.1e-152 544.3 Caulobacterales Bacteria 1MU6G@1224,2KG8Q@204458,2U0WI@28211,COG0318@1,COG0318@2 NA|NA|NA IQ AMP-binding enzyme C-terminal domain HIMHAPGP_00910 1248916.ANFY01000007_gene2449 2.5e-41 175.3 Sphingomonadales cinA 3.5.1.42 ko:K03742,ko:K03743 ko00760,map00760 R02322 RC00100 ko00000,ko00001,ko01000 Bacteria 1RHXH@1224,2K68F@204457,2UACN@28211,COG1546@1,COG1546@2 NA|NA|NA S Belongs to the CinA family HIMHAPGP_00911 1007104.SUS17_99 5.8e-66 257.3 Sphingomonadales rplI GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02939 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1RD0R@1224,2K0UT@204457,2TSC9@28211,COG0359@1,COG0359@2 NA|NA|NA J Binds to the 23S rRNA HIMHAPGP_00912 983920.Y88_3746 4.6e-32 143.3 Sphingomonadales rpsR GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02963 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1MZ8U@1224,2K5WV@204457,2UC13@28211,COG0238@1,COG0238@2 NA|NA|NA J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit HIMHAPGP_00913 1123267.JONN01000001_gene620 1.7e-35 155.6 Sphingomonadales rpsF GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904 4.3.1.19 ko:K01754,ko:K02990 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,ko03010,map00260,map00290,map01100,map01110,map01130,map01200,map01230,map03010 M00178,M00570 R00220,R00996 RC00418,RC02600 br01610,ko00000,ko00001,ko00002,ko01000,ko03011,ko03029 Bacteria 1RH82@1224,2K4F9@204457,2U767@28211,COG0360@1,COG0360@2 NA|NA|NA J Binds together with S18 to 16S ribosomal RNA HIMHAPGP_00914 1123240.ATVO01000008_gene2308 1.8e-88 333.2 Sphingomonadales gdhB GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016638,GO:0016639,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 R00243 RC00006,RC02799 ko00000,ko00001,ko01000 Bacteria 1MXNV@1224,2K0WP@204457,2TS89@28211,COG2902@1,COG2902@2 NA|NA|NA E glutamate dehydrogenase HIMHAPGP_00916 1502850.FG91_03411 1.8e-84 318.9 Sphingomonadales xthA2 3.1.11.2 ko:K01142 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 1MVMC@1224,2K09T@204457,2TRWQ@28211,COG0708@1,COG0708@2 NA|NA|NA L exodeoxyribonuclease III HIMHAPGP_00917 1248916.ANFY01000011_gene1066 1.7e-190 672.2 Sphingomonadales leuC 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1MVYR@1224,2K0IM@204457,2TR6K@28211,COG0065@1,COG0065@2 NA|NA|NA E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate HIMHAPGP_00918 1123240.ATVO01000005_gene1704 4.3e-116 424.5 Sphingomonadales yadG ko:K01990,ko:K09695 ko02010,map02010 M00252,M00254 ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.102 Bacteria 1MUW7@1224,2K06G@204457,2TR2Q@28211,COG1131@1,COG1131@2 NA|NA|NA V ABC-type multidrug transport system, ATPase component HIMHAPGP_00919 685778.AORL01000021_gene793 4.7e-18 97.1 Sphingomonadales GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016999,GO:0017000,GO:0017144,GO:0044237,GO:0044249 ko:K21781 ko00333,map00333 M00837,M00838 R06746 RC00039,RC01438 ko00000,ko00001,ko00002 Bacteria 1N83X@1224,2K6WR@204457,2UFBF@28211,COG0236@1,COG0236@2 NA|NA|NA IQ acyl carrier protein HIMHAPGP_00920 745310.G432_03445 1.2e-158 566.2 Sphingomonadales ldc 4.1.1.17 ko:K01581 ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130 M00134 R00670 RC00299 ko00000,ko00001,ko00002,ko01000 Bacteria 1MZ7Y@1224,2K02Y@204457,2TSKB@28211,COG0019@1,COG0019@2 NA|NA|NA E Belongs to the Orn Lys Arg decarboxylase class-II family HIMHAPGP_00921 1007104.SUS17_1033 2e-173 615.1 Sphingomonadales GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008612,GO:0009058,GO:0009987,GO:0010467,GO:0016740,GO:0016765,GO:0018193,GO:0018205,GO:0019538,GO:0034038,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564 2.5.1.46 ko:K00809 ko00000,ko01000 Bacteria 1MVC6@1224,2K1R2@204457,2TTRW@28211,COG1899@1,COG1899@2 NA|NA|NA O Belongs to the deoxyhypusine synthase family HIMHAPGP_00922 1470591.BW41_01983 4.9e-38 164.9 Sphingomonadales Bacteria 1R669@1224,2C59N@1,2K2GM@204457,2U2IK@28211,32TAY@2 NA|NA|NA HIMHAPGP_00923 1248916.ANFY01000009_gene200 2.9e-104 385.6 Sphingomonadales rumA 2.1.1.190 ko:K03215 ko00000,ko01000,ko03009 Bacteria 1MV3A@1224,2K0YT@204457,2TR40@28211,COG2265@1,COG2265@2 NA|NA|NA J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family HIMHAPGP_00924 1234595.C725_1108 4.6e-141 508.4 unclassified Alphaproteobacteria sppA GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006465,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0010467,GO:0016020,GO:0016021,GO:0016485,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051604,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564 ko:K04773 ko00000,ko01000,ko01002 Bacteria 1MUXE@1224,2TSXA@28211,4BPSS@82117,COG0616@1,COG0616@2 NA|NA|NA OU Peptidase family S49 HIMHAPGP_00925 1121124.JNIX01000010_gene884 1.4e-46 193.0 Caulobacterales GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 1RHQN@1224,2KGHE@204458,2U6ZM@28211,COG2860@1,COG2860@2 NA|NA|NA S UPF0126 domain HIMHAPGP_00926 1219045.BV98_000264 2.4e-195 688.3 Sphingomonadales lpd3 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1MU2U@1224,2K1EA@204457,2TRN7@28211,COG1249@1,COG1249@2 NA|NA|NA C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes HIMHAPGP_00927 1234595.C725_1780 4.4e-33 146.7 unclassified Alphaproteobacteria sucB GO:0003674,GO:0003824,GO:0004149,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008289,GO:0009060,GO:0009987,GO:0015980,GO:0016417,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016751,GO:0016999,GO:0017144,GO:0019752,GO:0031405,GO:0031406,GO:0032991,GO:0033293,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:0140096,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2766,iAPECO1_1312.APECO1_1352,iECED1_1282.ECED1_0696,iECOK1_1307.ECOK1_0726,iECS88_1305.ECS88_0752,iLF82_1304.LF82_2196,iNRG857_1313.NRG857_03235,iUMN146_1321.UM146_13990,iUTI89_1310.UTI89_C0722 Bacteria 1MUJD@1224,2TS5N@28211,4BPQ0@82117,COG0508@1,COG0508@2 NA|NA|NA C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) HIMHAPGP_00928 414684.RC1_2842 3.5e-75 288.5 Rhodospirillales Bacteria 1MUR2@1224,2JRMA@204441,2TUM7@28211,COG2030@1,COG2030@2 NA|NA|NA I N-terminal half of MaoC dehydratase HIMHAPGP_00929 1121004.ATVC01000033_gene2244 1.1e-25 123.6 Neisseriales pfiT Bacteria 1RGJ3@1224,2KPM6@206351,2VHGC@28216,COG1309@1,COG1309@2 NA|NA|NA K YsiA-like protein, C-terminal region HIMHAPGP_00932 1088721.NSU_4599 3.2e-13 80.1 Sphingomonadales Bacteria 1MX5C@1224,2K1CX@204457,2TRE6@28211,COG1432@1,COG1432@2 NA|NA|NA S OST-HTH/LOTUS domain HIMHAPGP_00934 1144307.PMI04_01449 1.3e-127 463.0 Sphingomonadales ko:K12979 ko00000,ko01000,ko01005 Bacteria 1MW3M@1224,2K07E@204457,2U5YV@28211,COG3555@1,COG3555@2 NA|NA|NA O Aspartyl/Asparaginyl beta-hydroxylase HIMHAPGP_00935 745310.G432_03910 2.3e-85 322.4 Sphingomonadales ypfJ GO:0005575,GO:0005576 ko:K07054 ko00000 Bacteria 1MU4U@1224,2K20W@204457,2TRCS@28211,COG2321@1,COG2321@2 NA|NA|NA S metalloprotease HIMHAPGP_00936 395961.Cyan7425_2602 4e-103 381.7 Cyanothece ko:K21430 ko00000,ko01000 Bacteria 1G2QD@1117,3KFRR@43988,COG2133@1,COG2133@2 NA|NA|NA G Glucose / Sorbosone dehydrogenase HIMHAPGP_00937 1335760.ASTG01000031_gene1840 9.3e-67 260.4 Sphingomonadales ko:K07090 ko00000 Bacteria 1MVBS@1224,2JZVA@204457,2TQW0@28211,COG0730@1,COG0730@2 NA|NA|NA S membrane transporter protein HIMHAPGP_00938 1207055.C100_13045 1.9e-148 532.3 Alphaproteobacteria Bacteria 1MWQD@1224,2U2IU@28211,COG1672@1,COG1672@2 NA|NA|NA S ATPase (AAA) HIMHAPGP_00940 383381.EH30_11805 1.2e-147 529.6 Sphingomonadales GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0008410,GO:0015977,GO:0016740,GO:0016782,GO:0043427,GO:0071704 2.8.3.16,2.8.3.20 ko:K07749,ko:K18313 R10640,R10641 RC00014 ko00000,ko01000 Bacteria 1MU2K@1224,2K0PV@204457,2TR7Q@28211,COG1804@1,COG1804@2 NA|NA|NA C dehydratase HIMHAPGP_00941 1234595.C725_0798 1.5e-116 426.0 unclassified Alphaproteobacteria GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009436,GO:0009987,GO:0015977,GO:0016054,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0032787,GO:0043427,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046185,GO:0046395,GO:0046487,GO:0071704,GO:0072329,GO:1901575 4.1.3.4,4.1.3.46 ko:K01640,ko:K18314 ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146 M00036,M00088 R01360,R08090,R10674 RC00502,RC00503,RC01118,RC01205,RC01946 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUMX@1224,2TT1R@28211,4BPCB@82117,COG0119@1,COG0119@2 NA|NA|NA E HMGL-like HIMHAPGP_00942 1248916.ANFY01000005_gene2727 1.2e-100 372.9 Sphingomonadales Bacteria 1MVYJ@1224,2K342@204457,2TRJ8@28211,COG1028@1,COG1028@2 NA|NA|NA IQ KR domain HIMHAPGP_00943 1234595.C725_2218 2.6e-174 618.6 Alphaproteobacteria Bacteria 1P3P1@1224,2TVM7@28211,COG2271@1,COG2271@2 NA|NA|NA G Major Facilitator Superfamily HIMHAPGP_00944 1248916.ANFY01000003_gene939 0.0 1200.3 Sphingomonadales glnD GO:0003674,GO:0003824,GO:0006082,GO:0006355,GO:0006464,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0006808,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0008652,GO:0008773,GO:0009058,GO:0009064,GO:0009084,GO:0009605,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0018175,GO:0018177,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0045893,GO:0045935,GO:0046394,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070569,GO:0070887,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0080090,GO:0090293,GO:0140096,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901698,GO:1901699,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 2.7.7.59 ko:K00990 ko02020,map02020 ko00000,ko00001,ko01000 Bacteria 1MV54@1224,2K0BN@204457,2TSV0@28211,COG2844@1,COG2844@2 NA|NA|NA O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen HIMHAPGP_00947 1007104.SUS17_3022 4.7e-79 301.2 Sphingomonadales flgG ko:K02392 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 1MVMA@1224,2K1WG@204457,2TRR4@28211,COG4786@1,COG4786@2 NA|NA|NA N flagellar basal-body rod protein FlgG HIMHAPGP_00948 1248916.ANFY01000017_gene1507 1.2e-42 179.9 Sphingomonadales flgH ko:K02393 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 1RDEY@1224,2K26G@204457,2TRHN@28211,COG2063@1,COG2063@2 NA|NA|NA N Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation HIMHAPGP_00949 1248916.ANFY01000017_gene1508 5.9e-120 437.6 Sphingomonadales flgI GO:0003674,GO:0005198,GO:0005575,GO:0005623,GO:0009288,GO:0009425,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464 ko:K02394 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 1MVKW@1224,2K00I@204457,2TQNX@28211,COG1706@1,COG1706@2 NA|NA|NA N Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation HIMHAPGP_00951 1248916.ANFY01000017_gene1510 8.4e-71 275.0 Sphingomonadales flgK ko:K02396 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 1MV2M@1224,2K1JD@204457,2U2HH@28211,COG1256@1,COG1256@2 NA|NA|NA N flagellar hook-associated protein HIMHAPGP_00952 1248916.ANFY01000017_gene1511 2.6e-25 122.9 Sphingomonadales flgL GO:0005575,GO:0005576,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464 ko:K02397 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 1QJQ3@1224,2KDIA@204457,2UF3K@28211,COG1344@1,COG1344@2 NA|NA|NA N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella HIMHAPGP_00953 1248916.ANFY01000017_gene1512 5.4e-105 387.5 Sphingomonadales motA ko:K02556 ko02020,ko02030,ko02040,map02020,map02030,map02040 ko00000,ko00001,ko02000,ko02035 1.A.30.1 Bacteria 1MXK3@1224,2K1GC@204457,2TR5A@28211,COG1291@1,COG1291@2 NA|NA|NA N With MotB forms the ion channels that couple flagellar rotation to proton sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine HIMHAPGP_00954 1248916.ANFY01000017_gene1513 2.3e-68 265.8 Sphingomonadales motB GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0009288,GO:0009425,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044425,GO:0044459,GO:0044461,GO:0044463,GO:0044464,GO:0071944,GO:0120100,GO:0120101 ko:K02557 ko02030,ko02040,map02030,map02040 ko00000,ko00001,ko02000,ko02035 1.A.30.1 Bacteria 1MW1Y@1224,2JZXH@204457,2TTW2@28211,COG1360@1,COG1360@2 NA|NA|NA N Flagellar motor protein HIMHAPGP_00955 1248916.ANFY01000005_gene2865 7.4e-235 820.1 Sphingomonadales uvrC GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016787,GO:0016788,GO:0030312,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1902494,GO:1905347,GO:1905348,GO:1990391 ko:K03703 ko03420,map03420 ko00000,ko00001,ko03400 Bacteria 1MV38@1224,2K1TK@204457,2TT32@28211,COG0322@1,COG0322@2 NA|NA|NA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision HIMHAPGP_00956 745310.G432_00315 2.1e-139 502.7 Sphingomonadales xcsE ko:K02454 ko03070,ko05111,map03070,map05111 M00331 ko00000,ko00001,ko00002,ko02044 3.A.15 Bacteria 1MU7V@1224,2K09N@204457,2TRMU@28211,COG2804@1,COG2804@2 NA|NA|NA NU General secretion pathway protein E HIMHAPGP_00957 1090318.ATTI01000001_gene1823 1e-74 286.6 Sphingomonadales rluB 5.4.99.19,5.4.99.20,5.4.99.21,5.4.99.22 ko:K06178,ko:K06181,ko:K06182,ko:K06183 ko00000,ko01000,ko03009 Bacteria 1MUCE@1224,2K0YS@204457,2TQP2@28211,COG1187@1,COG1187@2 NA|NA|NA J Belongs to the pseudouridine synthase RsuA family HIMHAPGP_00958 1545915.JROG01000004_gene2046 9.1e-36 156.8 Sphingomonadales rsmD GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052913,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.171 ko:K08316 R07234 RC00003 ko00000,ko01000,ko03009 Bacteria 1MXKW@1224,2K3X3@204457,2U70Y@28211,COG0742@1,COG0742@2 NA|NA|NA L Methyltransferase HIMHAPGP_00959 1248916.ANFY01000003_gene1045 1.1e-266 926.0 Sphingomonadales uvrD GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006289,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017116,GO:0022607,GO:0031297,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0042802,GO:0043142,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045005,GO:0046483,GO:0050896,GO:0051259,GO:0051260,GO:0051276,GO:0051716,GO:0065003,GO:0070035,GO:0070581,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 1MU0G@1224,2K04E@204457,2TS2B@28211,COG0210@1,COG0210@2 NA|NA|NA L DNA helicase HIMHAPGP_00960 279238.Saro_0291 5.4e-39 167.5 Sphingomonadales MA20_23190 Bacteria 1RKP9@1224,2KE2Y@204457,2VGBT@28211,COG4291@1,COG4291@2 NA|NA|NA S Protein of unknown function (DUF1345) HIMHAPGP_00961 1280952.HJA_09864 6.8e-258 896.7 Hyphomonadaceae exaA 1.1.2.8,1.1.5.5,1.1.9.1 ko:K00114,ko:K17760,ko:K22473 ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130 R05062,R05198,R05285,R09479 RC00087,RC00088,RC01039 ko00000,ko00001,ko01000 Bacteria 1MUQX@1224,2TS2Q@28211,43X6D@69657,COG2010@1,COG2010@2,COG4993@1,COG4993@2 NA|NA|NA CG alcohol dehydrogenase HIMHAPGP_00962 1429916.X566_02025 2.8e-54 218.4 Bradyrhizobiaceae Bacteria 1N05C@1224,2TT9T@28211,3JTG7@41294,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase HIMHAPGP_00963 1248916.ANFY01000003_gene794 1.2e-143 516.2 Sphingomonadales pnp GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 Bacteria 1MVB9@1224,2K0IJ@204457,2TRH3@28211,COG1185@1,COG1185@2 NA|NA|NA J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction HIMHAPGP_00964 392499.Swit_3809 2e-34 151.4 Sphingomonadales rpsO GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006378,GO:0006396,GO:0006397,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016071,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031123,GO:0031124,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043631,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02956 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1MZ2W@1224,2K622@204457,2UBRZ@28211,COG0184@1,COG0184@2 NA|NA|NA J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome HIMHAPGP_00965 1030157.AFMP01000040_gene1487 1.1e-95 356.7 Sphingomonadales truB GO:0000049,GO:0001522,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0031119,GO:0034337,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990481 5.4.99.25 ko:K03177 ko00000,ko01000,ko03016 Bacteria 1MV0N@1224,2K00T@204457,2TSJK@28211,COG0130@1,COG0130@2 NA|NA|NA J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs HIMHAPGP_00966 317655.Sala_3082 1.6e-11 76.6 Sphingomonadales ybaY ko:K09914 ko00000 Bacteria 1N8AF@1224,2K7D0@204457,2UGPH@28211,COG3126@1,COG3126@2 NA|NA|NA O Type III secretion system lipoprotein chaperone (YscW) HIMHAPGP_00967 1030157.AFMP01000016_gene2511 0.0 1116.3 Sphingomonadales polA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 Bacteria 1MU31@1224,2K1KW@204457,2TRJF@28211,COG0258@1,COG0258@2,COG0749@1,COG0749@2 NA|NA|NA L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity HIMHAPGP_00968 1248916.ANFY01000003_gene846 7.4e-231 806.6 Sphingomonadales 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 Bacteria 1MU6G@1224,2JZZB@204457,2TR2W@28211,COG0318@1,COG0318@2 NA|NA|NA IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II HIMHAPGP_00970 46429.BV95_03231 2.4e-160 572.0 Sphingomonadales atoC ko:K02481 ko00000,ko02022 Bacteria 1MU0N@1224,2K0MW@204457,2TQPG@28211,COG2204@1,COG2204@2 NA|NA|NA T Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains HIMHAPGP_00971 1248916.ANFY01000011_gene1231 1.6e-150 540.0 Sphingomonadales prsK Bacteria 1MU55@1224,2KEK6@204457,2TXJW@28211,COG4191@1,COG4191@2 NA|NA|NA T Domain present in phytochromes and cGMP-specific phosphodiesterases. HIMHAPGP_00973 1123240.ATVO01000003_gene283 7.5e-150 537.3 Sphingomonadales 3.1.3.1 ko:K01077 ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020 M00126 R02135,R04620 RC00017 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 Bacteria 1MXI2@1224,2K1RI@204457,2TTUZ@28211,COG1785@1,COG1785@2 NA|NA|NA P Belongs to the alkaline phosphatase family HIMHAPGP_00974 1123240.ATVO01000003_gene284 9e-98 363.6 Sphingomonadales Bacteria 1MUNT@1224,2K1Y3@204457,2TU3Y@28211,COG3491@1,COG3491@2 NA|NA|NA C Belongs to the iron ascorbate-dependent oxidoreductase family HIMHAPGP_00975 1449049.JONW01000011_gene2126 5.5e-183 647.5 Caulobacterales 1.1.99.1 ko:K00108 ko00260,ko01100,map00260,map01100 M00555 R01025 RC00087 ko00000,ko00001,ko00002,ko01000 Bacteria 1MV19@1224,2KFEH@204458,2TQKQ@28211,COG2303@1,COG2303@2 NA|NA|NA E Belongs to the GMC oxidoreductase family HIMHAPGP_00976 1248916.ANFY01000004_gene1746 2.2e-143 515.4 Sphingomonadales dapE GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009014,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0032153,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0046872,GO:0046914,GO:0050897,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 iECP_1309.ECP_2485,iIT341.HP0212 Bacteria 1MW6G@1224,2K0C3@204457,2TT0J@28211,COG0624@1,COG0624@2 NA|NA|NA E Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls HIMHAPGP_00977 685778.AORL01000016_gene2310 3e-47 195.3 Sphingomonadales 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 Bacteria 1PHM1@1224,2K0C9@204457,2TTQZ@28211,COG0625@1,COG0625@2 NA|NA|NA O Glutathione S-transferase HIMHAPGP_00978 1123240.ATVO01000005_gene1920 3.6e-48 198.7 Sphingomonadales Bacteria 1RAXU@1224,2K33E@204457,2U682@28211,COG2207@1,COG2207@2 NA|NA|NA K Helix-turn-helix domain HIMHAPGP_00979 1123240.ATVO01000007_gene2152 4.5e-201 707.2 Sphingomonadales MA20_45145 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1MU5G@1224,2JZW6@204457,2TS1R@28211,COG0183@1,COG0183@2 NA|NA|NA I Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation HIMHAPGP_00980 1174684.EBMC1_16104 3.3e-146 524.6 Sphingomonadales 1.13.12.16 ko:K00459 ko00910,map00910 R00025 RC02541,RC02759 ko00000,ko00001,ko01000 Bacteria 1MWPC@1224,2K1CK@204457,2TQRT@28211,COG2070@1,COG2070@2 NA|NA|NA S 2-nitropropane dioxygenase HIMHAPGP_00981 1280954.HPO_17993 1.6e-30 138.7 Alphaproteobacteria Bacteria 1NF7U@1224,2UH89@28211,COG3631@1,COG3631@2 NA|NA|NA S SnoaL-like domain HIMHAPGP_00982 1174684.EBMC1_14635 8e-101 373.2 Sphingomonadales Bacteria 1PMH5@1224,2K8H1@204457,2TVAY@28211,COG2128@1,COG2128@2 NA|NA|NA S Carboxymuconolactone decarboxylase family HIMHAPGP_00983 1537715.JQFJ01000005_gene130 3.4e-71 274.6 Sphingomonadales Bacteria 1MWCV@1224,2KANC@204457,2U6HU@28211,COG0346@1,COG0346@2 NA|NA|NA E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily HIMHAPGP_00984 1504981.KO116_0319 8.9e-142 510.4 Oceanospirillales Bacteria 1MU6Y@1224,1RQX2@1236,1XIU0@135619,COG0277@1,COG0277@2 NA|NA|NA C FAD linked oxidase HIMHAPGP_00985 1282876.BAOK01000001_gene2527 1.4e-124 453.0 unclassified Alphaproteobacteria lldD 1.1.2.3 ko:K00101 ko00620,ko01100,map00620,map01100 R00196 RC00044 ko00000,ko00001,ko01000 Bacteria 1MUEZ@1224,2TQNW@28211,4BPX6@82117,COG1304@1,COG1304@2 NA|NA|NA C L-lactate dehydrogenase HIMHAPGP_00986 983920.Y88_3787 1.7e-197 695.7 Sphingomonadales 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 Bacteria 1MX6Q@1224,2K375@204457,2TR5N@28211,COG0028@1,COG0028@2 NA|NA|NA EH Thiamine pyrophosphate enzyme, N-terminal TPP binding domain HIMHAPGP_00987 1007104.SUS17_2322 1.5e-248 865.5 Sphingomonadales btuB ko:K02014,ko:K16092 ko00000,ko02000 1.B.14,1.B.14.3 Bacteria 1MW63@1224,2K12C@204457,2TT3G@28211,COG4206@1,COG4206@2 NA|NA|NA H receptor HIMHAPGP_00988 670307.HYPDE_25958 1.2e-32 145.2 Alphaproteobacteria Bacteria 1N70V@1224,2E3IE@1,2UE6F@28211,32YGW@2 NA|NA|NA S Hexameric tyrosine-coordinated heme protein (HTHP) HIMHAPGP_00989 450851.PHZ_c2881 1.8e-63 249.2 Alphaproteobacteria Bacteria 1MZAM@1224,2US5F@28211,COG1670@1,COG1670@2 NA|NA|NA J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins HIMHAPGP_00990 279238.Saro_2501 2.6e-126 458.8 Sphingomonadales Bacteria 1MVY1@1224,2K2BY@204457,2TVJ9@28211,COG1804@1,COG1804@2 NA|NA|NA C acyl-CoA transferases carnitine dehydratase HIMHAPGP_00991 1123269.NX02_16160 5.4e-23 114.8 Sphingomonadales tonB2 ko:K03832 ko00000,ko02000 2.C.1.1 Bacteria 1NB5F@1224,2KDGQ@204457,2UJ8K@28211,COG0810@1,COG0810@2 NA|NA|NA M Gram-negative bacterial TonB protein C-terminal HIMHAPGP_00992 190650.CC_0576 5.8e-79 301.2 Caulobacterales iaaA 3.4.19.5,3.5.1.1,3.5.1.26 ko:K01424,ko:K01444,ko:K13051 ko00250,ko00460,ko00511,ko01100,ko01110,ko04142,map00250,map00460,map00511,map01100,map01110,map04142 R00485 RC00010,RC02798 ko00000,ko00001,ko01000,ko01002 Bacteria 1PJQ2@1224,2KHPR@204458,2VEJ4@28211,COG1446@1,COG1446@2 NA|NA|NA E Asparaginase HIMHAPGP_00993 1292034.OR37_03023 4.6e-17 95.1 Caulobacterales GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141 Bacteria 1RI3V@1224,2KGWG@204458,2UAJ5@28211,COG1309@1,COG1309@2 NA|NA|NA K tetR family HIMHAPGP_00994 314265.R2601_13514 2.1e-21 109.0 Alphaproteobacteria Bacteria 1RD7R@1224,2A5G6@1,2U8Y0@28211,30U67@2 NA|NA|NA HIMHAPGP_00995 317655.Sala_1912 0.0 1139.8 Sphingomonadales ko:K02014 ko00000,ko02000 1.B.14 Bacteria 1R479@1224,2K147@204457,2TV3V@28211,COG1629@1,COG1629@2,COG4771@2 NA|NA|NA P COG1629 Outer membrane receptor proteins, mostly Fe transport HIMHAPGP_00996 745310.G432_16870 7e-158 563.9 Sphingomonadales rhlE 3.6.4.13 ko:K11927 ko03018,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 1MU49@1224,2K0CY@204457,2TR6Q@28211,COG0513@1,COG0513@2 NA|NA|NA L Belongs to the DEAD box helicase family HIMHAPGP_00997 1123240.ATVO01000005_gene1726 1.6e-98 365.9 Sphingomonadales 5.3.3.18 ko:K15866 ko00360,ko01120,map00360,map01120 R09837,R09839 RC00004,RC00326,RC02689,RC03003 ko00000,ko00001,ko01000 Bacteria 1MVQN@1224,2K0UE@204457,2TUXD@28211,COG1024@1,COG1024@2 NA|NA|NA I enoyl-CoA hydratase HIMHAPGP_00998 1120705.FG95_03870 1.5e-35 156.0 Sphingomonadales ntaB Bacteria 1RGYM@1224,2K5IK@204457,2UCHI@28211,COG1853@1,COG1853@2 NA|NA|NA I Flavin reductase like domain HIMHAPGP_00999 1123269.NX02_26010 1.2e-67 263.5 Sphingomonadales eamA2 Bacteria 1MXJY@1224,2K0J7@204457,2TVBG@28211,COG0697@1,COG0697@2 NA|NA|NA EG Permeases of the drug metabolite transporter (DMT) superfamily HIMHAPGP_01000 1112212.JH584235_gene2596 1.1e-96 360.1 Sphingomonadales ltaE 4.1.2.48 ko:K01620 ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 R00751,R06171 RC00312,RC00372 ko00000,ko00001,ko01000 Bacteria 1MWCR@1224,2K0EJ@204457,2TSUA@28211,COG2008@1,COG2008@2 NA|NA|NA E Threonine aldolase HIMHAPGP_01001 1030157.AFMP01000044_gene1733 4.9e-147 528.1 Sphingomonadales recN GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 ko:K03631 ko00000,ko03400 Bacteria 1MUNP@1224,2K043@204457,2TREW@28211,COG0497@1,COG0497@2 NA|NA|NA L May be involved in recombinational repair of damaged DNA HIMHAPGP_01002 279238.Saro_1732 8.2e-98 363.6 Sphingomonadales bamD GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 ko:K05807,ko:K08309 ko00000,ko01000,ko01011,ko02000 1.B.33.1 GH23 Bacteria 1MVS5@1224,2JZVK@204457,2TRZ5@28211,COG4105@1,COG4105@2 NA|NA|NA M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HIMHAPGP_01003 685778.AORL01000021_gene1087 9.7e-94 351.3 Sphingomonadales 5.2.1.8 ko:K01802,ko:K03770,ko:K03771 ko00000,ko01000,ko03110 Bacteria 1MWV0@1224,2K0KV@204457,2TRYU@28211,COG0760@1,COG0760@2 NA|NA|NA O peptidylprolyl isomerase HIMHAPGP_01005 1234595.C725_0236 4e-127 461.1 unclassified Alphaproteobacteria ilvE 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 1MVB0@1224,2TR1H@28211,4BPD3@82117,COG0115@1,COG0115@2 NA|NA|NA E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family HIMHAPGP_01006 46429.BV95_03117 3.3e-185 654.4 Sphingomonadales typA GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840 ko:K06207 ko00000 Bacteria 1MV5Q@1224,2K169@204457,2TR63@28211,COG1217@1,COG1217@2 NA|NA|NA T GTP-binding protein TypA HIMHAPGP_01007 1234595.C725_1088 3.5e-30 139.0 Alphaproteobacteria ko:K15539 ko00000 Bacteria 1RFJY@1224,2U90M@28211,COG1426@1,COG1426@2 NA|NA|NA S Helix-turn-helix domain HIMHAPGP_01008 1248916.ANFY01000010_gene454 1.5e-21 110.5 Sphingomonadales cpoB Bacteria 1R8C4@1224,2K0FK@204457,2VBNQ@28211,COG1729@1,COG1729@2 NA|NA|NA S protein conserved in bacteria HIMHAPGP_01010 1090320.KB900605_gene2116 9.3e-39 166.4 Sphingomonadales hspQ ko:K11940 ko00000,ko03036 Bacteria 1RHM7@1224,2K54K@204457,2U9MS@28211,COG3785@1,COG3785@2 NA|NA|NA S DNA-binding protein HIMHAPGP_01011 702113.PP1Y_Mpl5732 2.2e-132 479.2 Sphingomonadales ko:K01138 ko00000,ko01000 Bacteria 1MUJH@1224,2K947@204457,2TSB8@28211,COG3119@1,COG3119@2 NA|NA|NA P Sulfatase HIMHAPGP_01012 69395.JQLZ01000001_gene2731 2.5e-72 279.3 Caulobacterales ko:K02529 ko00000,ko03000 Bacteria 1MVUR@1224,2KG8E@204458,2TRMS@28211,COG1609@1,COG1609@2 NA|NA|NA K Transcriptional regulator HIMHAPGP_01013 1088721.NSU_3349 1.2e-40 173.7 Sphingomonadales Bacteria 1R4AU@1224,2K6TD@204457,2UBDM@28211,COG0657@1,COG0657@2 NA|NA|NA I Carboxylesterase family HIMHAPGP_01014 1449076.JOOE01000001_gene3037 2.4e-233 815.5 Sphingomonadales ko:K02014 ko00000,ko02000 1.B.14 Bacteria 1MWKN@1224,2K1H6@204457,2TU3F@28211,COG1629@1,COG4771@2 NA|NA|NA P TonB-dependent receptor HIMHAPGP_01015 1219045.BV98_000860 5.3e-221 773.9 Sphingomonadales mdsA 3.1.6.14 ko:K01137 ko00531,ko01100,ko04142,map00531,map01100,map04142 M00078,M00079 R07808,R07819 ko00000,ko00001,ko00002,ko01000 Bacteria 1MV0B@1224,2KCQN@204457,2TRI6@28211,COG3119@1,COG3119@2 NA|NA|NA P Domain of unknown function (DUF4976) HIMHAPGP_01016 1379701.JPJC01000017_gene3286 3.5e-142 511.9 Sphingomonadales GO:0001503,GO:0001505,GO:0001507,GO:0001540,GO:0001649,GO:0002076,GO:0002791,GO:0002793,GO:0003674,GO:0003824,GO:0003990,GO:0004104,GO:0005488,GO:0005515,GO:0005518,GO:0005575,GO:0005576,GO:0005604,GO:0005605,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005794,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006581,GO:0006629,GO:0006644,GO:0006650,GO:0006656,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0007155,GO:0007267,GO:0007268,GO:0007271,GO:0007275,GO:0007399,GO:0007416,GO:0007517,GO:0008144,GO:0008150,GO:0008152,GO:0008283,GO:0008291,GO:0008610,GO:0008654,GO:0009056,GO:0009058,GO:0009059,GO:0009611,GO:0009987,GO:0010646,GO:0010648,GO:0010817,GO:0012505,GO:0016020,GO:0016043,GO:0016787,GO:0016788,GO:0017144,GO:0017171,GO:0019538,GO:0019637,GO:0022607,GO:0022610,GO:0023051,GO:0023052,GO:0023057,GO:0030154,GO:0031012,GO:0032222,GO:0032223,GO:0032501,GO:0032502,GO:0032879,GO:0032880,GO:0033218,GO:0034641,GO:0034645,GO:0042133,GO:0042135,GO:0042136,GO:0042165,GO:0042166,GO:0042277,GO:0042445,GO:0042447,GO:0042562,GO:0042737,GO:0042802,GO:0042803,GO:0042982,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043236,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044420,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045017,GO:0045202,GO:0046470,GO:0046474,GO:0046483,GO:0046486,GO:0046983,GO:0048468,GO:0048471,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048731,GO:0048856,GO:0048869,GO:0050708,GO:0050714,GO:0050789,GO:0050794,GO:0050804,GO:0050805,GO:0050808,GO:0050840,GO:0050896,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051222,GO:0051223,GO:0052689,GO:0061061,GO:0062023,GO:0065007,GO:0065008,GO:0070201,GO:0070405,GO:0071704,GO:0071840,GO:0071944,GO:0090087,GO:0090304,GO:0090407,GO:0097164,GO:0098916,GO:0099177,GO:0099536,GO:0099537,GO:1900619,GO:1901360,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903530,GO:1903532,GO:1904951 ko:K03929 ko00000,ko01000 CE10 Bacteria 1MVQZ@1224,2K1A5@204457,2TUA9@28211,COG2272@1,COG2272@2 NA|NA|NA I Belongs to the type-B carboxylesterase lipase family HIMHAPGP_01017 1030157.AFMP01000042_gene1288 2.3e-241 841.6 Sphingomonadales kup ko:K03549 ko00000,ko02000 2.A.72 Bacteria 1MUVH@1224,2JZUZ@204457,2TRVJ@28211,COG3158@1,COG3158@2 NA|NA|NA P Transport of potassium into the cell HIMHAPGP_01018 1234595.C725_2230 3.1e-30 138.7 Alphaproteobacteria cycH ko:K02200 ko00000 Bacteria 1RB0I@1224,2U69S@28211,COG4235@1,COG4235@2 NA|NA|NA O Cytochrome c biogenesis factor HIMHAPGP_01019 452662.SJA_C1-17470 6.2e-24 117.1 Sphingomonadales ccmH GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0015035,GO:0015036,GO:0016020,GO:0016043,GO:0016491,GO:0016667,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0018193,GO:0018198,GO:0018378,GO:0019538,GO:0022607,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0098552,GO:0098567,GO:1901564 ko:K02198,ko:K02200,ko:K04016,ko:K04017,ko:K04018 R05712 RC00176 ko00000,ko02000 9.B.14.1 Bacteria 1MZZ5@1224,2K57D@204457,2U96P@28211,COG3088@1,COG3088@2 NA|NA|NA O subunit of a heme lyase HIMHAPGP_01020 1122970.AUHC01000009_gene264 6.5e-48 197.2 Sphingomonadales ccmG ko:K02199 ko00000,ko03110 Bacteria 1RI3N@1224,2K4IY@204457,2TSEW@28211,COG0526@1,COG0526@2 NA|NA|NA CO Alkyl hydroperoxide reductase HIMHAPGP_01021 1030157.AFMP01000042_gene1293 8e-181 640.6 Sphingomonadales ccmF GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0018193,GO:0018198,GO:0018378,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564 ko:K02198,ko:K04016 R05712 RC00176 ko00000,ko02000 9.B.14.1 Bacteria 1MUQS@1224,2K1MA@204457,2TRNG@28211,COG1138@1,COG1138@2 NA|NA|NA O cytochrome C HIMHAPGP_01022 1234595.C725_2234 3.2e-35 154.8 unclassified Alphaproteobacteria ccmE GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006807,GO:0006810,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0015886,GO:0016020,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0051179,GO:0051181,GO:0051234,GO:0065003,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0097159,GO:0098552,GO:0098567,GO:1901363,GO:1901564,GO:1901678 ko:K02197 ko00000 iSSON_1240.SSON_2255 Bacteria 1RHN5@1224,2U99J@28211,4BQMC@82117,COG2332@1,COG2332@2 NA|NA|NA O Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH HIMHAPGP_01024 1234595.C725_2236 1.6e-76 292.7 Alphaproteobacteria ccmC GO:0001539,GO:0002048,GO:0002049,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006518,GO:0006629,GO:0006643,GO:0006664,GO:0006807,GO:0006810,GO:0006928,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009237,GO:0009247,GO:0009636,GO:0009987,GO:0015886,GO:0016020,GO:0016021,GO:0016209,GO:0016491,GO:0016684,GO:0019184,GO:0019290,GO:0019748,GO:0031224,GO:0031226,GO:0034641,GO:0040011,GO:0042221,GO:0043043,GO:0043107,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044425,GO:0044459,GO:0044464,GO:0044550,GO:0046467,GO:0048870,GO:0050896,GO:0051179,GO:0051181,GO:0051186,GO:0051188,GO:0051234,GO:0051674,GO:0051716,GO:0055114,GO:0070887,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0071973,GO:0071975,GO:0071977,GO:0071978,GO:0097237,GO:0097588,GO:0098754,GO:0098869,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1901678,GO:1903509,GO:1990748 ko:K02195 ko02010,map02010 M00259 ko00000,ko00001,ko00002,ko02000 3.A.1.107 iECDH1ME8569_1439.ECDH1ME8569_2134,iSFV_1184.SFV_2275,iSFxv_1172.SFxv_2517,iUTI89_1310.UTI89_C2477,ic_1306.c2736 Bacteria 1MU61@1224,2TSW8@28211,COG0755@1,COG0755@2 NA|NA|NA O Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes HIMHAPGP_01025 1123240.ATVO01000008_gene2374 7.7e-40 170.6 Sphingomonadales ccmB GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0031224,GO:0031226,GO:0032991,GO:0042623,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.41 ko:K02193,ko:K02194 ko02010,map02010 M00259 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.107 iECO111_1330.ECO111_2936,iYL1228.KPN_02080 Bacteria 1NJB0@1224,2K43Z@204457,2TUSG@28211,COG2386@1,COG2386@2 NA|NA|NA O Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes HIMHAPGP_01026 1123269.NX02_00165 8.8e-11 72.4 Sphingomonadales Bacteria 1NG8P@1224,2K74D@204457,2UJB2@28211,COG5509@1,COG5509@2 NA|NA|NA S Protein of unknown function (DUF1192) HIMHAPGP_01027 1248916.ANFY01000007_gene2586 3e-107 395.2 Sphingomonadales ppsC 1.6.5.5 ko:K00344 ko00000,ko01000 Bacteria 1MX8A@1224,2K115@204457,2TR1J@28211,COG0604@1,COG0604@2 NA|NA|NA C NADPH quinone HIMHAPGP_01028 1173023.KE650771_gene734 1.4e-22 113.2 Cyanobacteria Bacteria 1GCVT@1117,28JPH@1,33QNE@2 NA|NA|NA S PAP_fibrillin HIMHAPGP_01029 551789.ATVJ01000003_gene82 3e-94 351.7 Hyphomonadaceae 4.2.1.149,4.2.1.17 ko:K01692,ko:K08299 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093,R10675 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 Bacteria 1MWZC@1224,2TRIH@28211,43WPX@69657,COG1024@1,COG1024@2 NA|NA|NA I Belongs to the enoyl-CoA hydratase isomerase family HIMHAPGP_01030 1090320.KB900605_gene3541 6.7e-25 119.4 Sphingomonadales suhB GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0042578,GO:0043167,GO:0043169,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0046872,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 Bacteria 1N7D7@1224,2K5WG@204457,2UF6T@28211,COG0483@1,COG0483@2 NA|NA|NA G Domain of unknown function (DUF4170) HIMHAPGP_01031 1248916.ANFY01000009_gene119 1.6e-39 169.5 Sphingomonadales Bacteria 1RD76@1224,2K4AW@204457,2U5GR@28211,COG0663@1,COG0663@2 NA|NA|NA S COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily HIMHAPGP_01032 1248916.ANFY01000009_gene118 1.4e-38 166.4 Sphingomonadales ttg2D ko:K07323 ko02010,map02010 M00210 ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 Bacteria 1Q05B@1224,2K4Q6@204457,2UEAQ@28211,COG2854@1,COG2854@2 NA|NA|NA Q toluene tolerance family protein HIMHAPGP_01035 685778.AORL01000021_gene1034 2.5e-08 65.5 Sphingomonadales Bacteria 1NGP8@1224,2EJM3@1,2KE6M@204457,2UKSN@28211,33DC0@2 NA|NA|NA HIMHAPGP_01036 1123240.ATVO01000003_gene580 8.6e-162 576.6 Sphingomonadales acaB 2.3.1.16,2.3.1.9 ko:K00626,ko:K00632 ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00087,M00088,M00095,M00113,M00373,M00374,M00375 R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1MU5G@1224,2K0V0@204457,2TQQ7@28211,COG0183@1,COG0183@2 NA|NA|NA I Belongs to the thiolase family HIMHAPGP_01037 1123240.ATVO01000003_gene581 1.3e-52 212.6 Sphingomonadales nodN 4.2.1.55 ko:K17865 ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200 M00373 R03027 RC00831 ko00000,ko00001,ko00002,ko01000 Bacteria 1RHPH@1224,2K4IV@204457,2U9GG@28211,COG2030@1,COG2030@2 NA|NA|NA I MaoC like domain HIMHAPGP_01039 1234595.C725_1060 1.2e-143 516.2 unclassified Alphaproteobacteria leuB GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1MUH4@1224,2TQKG@28211,4BP7K@82117,COG0473@1,COG0473@2 NA|NA|NA CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate HIMHAPGP_01040 1248916.ANFY01000003_gene460 1.6e-79 302.4 Sphingomonadales leuD 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1MVXB@1224,2JZWQ@204457,2TRRS@28211,COG0066@1,COG0066@2 NA|NA|NA E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate HIMHAPGP_01041 1502851.FG93_05923 1.5e-65 255.8 Bradyrhizobiaceae ppa GO:0000287,GO:0003674,GO:0003824,GO:0004427,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006793,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050355 3.6.1.1 ko:K01507 ko00190,map00190 ko00000,ko00001,ko01000 iJN746.PP_0538,iPC815.YPO3521 Bacteria 1RA2F@1224,2TQZM@28211,3JR9D@41294,COG0221@1,COG0221@2 NA|NA|NA C Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions HIMHAPGP_01042 371042.NG99_12230 3.1e-13 80.1 Gammaproteobacteria Bacteria 1MU72@1224,1RR7A@1236,COG5276@1,COG5276@2 NA|NA|NA S LVIVD repeat HIMHAPGP_01043 685778.AORL01000021_gene491 1.8e-149 535.8 Sphingomonadales argJ GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35,2.7.2.8 ko:K00620,ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282,R02649 RC00002,RC00004,RC00043,RC00064 ko00000,ko00001,ko00002,ko01000 iLJ478.TM1783 Bacteria 1MU0T@1224,2K035@204457,2TS98@28211,COG1364@1,COG1364@2 NA|NA|NA E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate HIMHAPGP_01044 1379701.JPJC01000014_gene175 1.6e-82 312.8 Sphingomonadales ko:K02016,ko:K16092 ko02010,map02010 M00240 ko00000,ko00001,ko00002,ko02000 1.B.14.3,3.A.1.14 Bacteria 1RAUP@1224,2K23T@204457,2TUB0@28211,COG0614@1,COG0614@2 NA|NA|NA P ABC-type Fe3 -hydroxamate transport system, periplasmic component HIMHAPGP_01045 1379701.JPJC01000014_gene174 1.3e-113 416.4 Sphingomonadales ko:K02015 ko02010,map02010 M00240 ko00000,ko00001,ko00002,ko02000 3.A.1.14 Bacteria 1MV9W@1224,2K0DB@204457,2TR9A@28211,COG0609@1,COG0609@2 NA|NA|NA P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily HIMHAPGP_01046 314266.SKA58_09531 2.8e-79 302.0 Sphingomonadales 3.6.3.34 ko:K02013 ko02010,map02010 M00240 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 Bacteria 1QPWJ@1224,2K1EJ@204457,2U1TK@28211,COG1120@1,COG1120@2 NA|NA|NA HP ABC transporter HIMHAPGP_01047 158500.BV97_01257 2e-135 489.2 Sphingomonadales fahA 3.7.1.2 ko:K01555 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R01364 RC00326,RC00446 ko00000,ko00001,ko00002,ko01000,ko04147 iJN746.PP_4620 Bacteria 1MW82@1224,2K0SS@204457,2TRKH@28211,COG0179@1,COG0179@2 NA|NA|NA Q Fumarylacetoacetase HIMHAPGP_01048 1248916.ANFY01000014_gene41 2.1e-42 179.5 Sphingomonadales Bacteria 1QD8E@1224,2K4W9@204457,2TRQ7@28211,COG0589@1,COG0589@2 NA|NA|NA T Belongs to the universal stress protein A family HIMHAPGP_01050 1105367.CG50_05270 2.5e-07 60.5 Alphaproteobacteria Bacteria 1Q6RV@1224,2US3U@28211,COG1853@1,COG1853@2 NA|NA|NA S Flavin reductase like domain HIMHAPGP_01051 1229204.AMYY01000025_gene547 2.7e-25 121.3 Alphaproteobacteria mntP GO:0000041,GO:0003674,GO:0005215,GO:0005384,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006828,GO:0008150,GO:0008324,GO:0010035,GO:0010038,GO:0010042,GO:0015075,GO:0015318,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0042221,GO:0044464,GO:0046873,GO:0046915,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071421,GO:0071944,GO:0098655,GO:0098660,GO:0098662 Bacteria 1NWBY@1224,2U6TQ@28211,COG1971@1,COG1971@2 NA|NA|NA P Probably functions as a manganese efflux pump HIMHAPGP_01052 1123240.ATVO01000006_gene1397 3.1e-27 128.3 Sphingomonadales ybgC ko:K07107 ko00000,ko01000 Bacteria 1NBU7@1224,2K5KH@204457,2UF7N@28211,COG0824@1,COG0824@2 NA|NA|NA S Thioesterase superfamily HIMHAPGP_01053 1280954.HPO_01440 1.5e-143 516.2 Alphaproteobacteria Bacteria 1MV8Q@1224,2TU15@28211,COG2124@1,COG2124@2 NA|NA|NA C cytochrome P-450 HIMHAPGP_01055 1030157.AFMP01000040_gene1615 7.9e-20 104.0 Sphingomonadales Bacteria 1RFIZ@1224,2K410@204457,2U7B1@28211,COG3748@1,COG3748@2 NA|NA|NA S Urate oxidase N-terminal HIMHAPGP_01056 1090320.KB900605_gene2674 6.1e-103 380.6 Sphingomonadales ko:K02477 ko00000,ko02022 Bacteria 1MUE8@1224,2K1DU@204457,2TSPC@28211,COG3279@1,COG3279@2 NA|NA|NA T Response regulator of the LytR AlgR family HIMHAPGP_01057 1123240.ATVO01000006_gene1620 1.8e-130 472.6 Sphingomonadales yesM Bacteria 1MXVQ@1224,2JZWJ@204457,2U16F@28211,COG2972@1,COG2972@2 NA|NA|NA T Histidine kinase HIMHAPGP_01058 1112214.AHIS01000047_gene1972 8.7e-49 201.1 Sphingomonadales holA 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 1N7AB@1224,2K0ER@204457,2UHPM@28211,COG1466@1,COG1466@2 NA|NA|NA L DNA polymerase III HIMHAPGP_01059 1123269.NX02_25360 4.1e-41 174.5 Sphingomonadales ko:K03643 ko00000,ko02000 1.B.42.1 Bacteria 1RKF8@1224,2K4FJ@204457,2UACI@28211,COG5468@1,COG5468@2 NA|NA|NA S Lipopolysaccharide-assembly HIMHAPGP_01060 392499.Swit_2852 2.2e-252 878.2 Sphingomonadales leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 iECOK1_1307.ECOK1_0652,iECS88_1305.ECS88_0684,iNRG857_1313.NRG857_02925,iPC815.YPO2610 Bacteria 1MV47@1224,2K0Q0@204457,2TQPK@28211,COG0495@1,COG0495@2 NA|NA|NA J Belongs to the class-I aminoacyl-tRNA synthetase family HIMHAPGP_01061 1088721.NSU_1695 9.6e-13 78.2 Sphingomonadales rho GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576 ko:K02887,ko:K03628 ko03010,ko03018,map03010,map03018 M00178 br01610,ko00000,ko00001,ko00002,ko03011,ko03019,ko03021 Bacteria 1MUCF@1224,2K1UD@204457,2TRB4@28211,COG1158@1,COG1158@2 NA|NA|NA K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template HIMHAPGP_01062 1219049.SP5_041_00080 1.1e-150 540.0 Sphingomonadales dapE Bacteria 1MWJS@1224,2K1MW@204457,2TUHT@28211,COG0624@1,COG0624@2 NA|NA|NA E Acetylornithine deacetylase Succinyl-diaminopimelate HIMHAPGP_01063 1207055.C100_11550 9.9e-145 520.4 Sphingomonadales Bacteria 1MUZ7@1224,2K2N3@204457,2U663@28211,COG2234@1,COG2234@2 NA|NA|NA S Peptidase family M28 HIMHAPGP_01064 1248916.ANFY01000010_gene352 2e-15 88.2 Sphingomonadales Bacteria 1NG2G@1224,2DSC6@1,2KEKG@204457,2UHCQ@28211,33FGJ@2 NA|NA|NA HIMHAPGP_01066 1234595.C725_2775 9.6e-42 177.6 Alphaproteobacteria Bacteria 1RC15@1224,2U5PB@28211,COG1530@1,COG1530@2 NA|NA|NA J ribonuclease E activity HIMHAPGP_01067 745310.G432_06860 2.2e-60 238.8 Sphingomonadales maf GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0030312,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0047429,GO:0071944 2.1.1.190 ko:K03215,ko:K06287 ko00000,ko01000,ko03009 Bacteria 1RH6H@1224,2K3WJ@204457,2TSS5@28211,COG0424@1,COG0424@2 NA|NA|NA D Maf-like protein HIMHAPGP_01068 279238.Saro_1058 1.1e-30 138.7 Sphingomonadales infA GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009986,GO:0030246,GO:0030247,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:2001065 ko:K02518 ko00000,ko03012 Bacteria 1MZFU@1224,2K5VJ@204457,2UBRU@28211,COG0361@1,COG0361@2 NA|NA|NA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex HIMHAPGP_01070 1234595.C725_0862 3.6e-79 301.6 unclassified Alphaproteobacteria dapB GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.17.1.8 ko:K00215,ko:K03546 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000,ko03400 iIT341.HP0510,iLJ478.TM1520,iSbBS512_1146.SbBS512_E0035 Bacteria 1MUCT@1224,2TSFJ@28211,4BQ3I@82117,COG0289@1,COG0289@2 NA|NA|NA E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate HIMHAPGP_01071 1248916.ANFY01000003_gene893 2.2e-51 208.4 Sphingomonadales rplQ GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02879,ko:K16193 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1RCWN@1224,2K4J0@204457,2U749@28211,COG0203@1,COG0203@2 NA|NA|NA J Ribosomal protein L17 HIMHAPGP_01072 1470591.BW41_02065 1.3e-145 522.7 Sphingomonadales rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 Bacteria 1MU75@1224,2K0R2@204457,2TSI0@28211,COG0202@1,COG0202@2 NA|NA|NA K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates HIMHAPGP_01073 1550073.JROH01000010_gene1248 1.7e-58 231.9 Sphingomonadales rpsK GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02948 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1RD0A@1224,2K3VT@204457,2U717@28211,COG0100@1,COG0100@2 NA|NA|NA J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome HIMHAPGP_01074 383372.Rcas_3765 3.5e-57 228.8 Chloroflexia rbsK GO:0003674,GO:0003824,GO:0004747,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019303,GO:0019321,GO:0019323,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046835,GO:0071704,GO:1901575 2.7.1.15,2.7.1.4 ko:K00847,ko:K00852 ko00030,ko00051,ko00500,ko00520,ko01100,map00030,map00051,map00500,map00520,map01100 R00760,R00867,R01051,R02750,R03920 RC00002,RC00017 ko00000,ko00001,ko01000 iE2348C_1286.E2348C_4062,iEcDH1_1363.EcDH1_4215 Bacteria 2G6JH@200795,376FG@32061,COG0524@1,COG0524@2 NA|NA|NA H Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway HIMHAPGP_01075 1123277.KB893182_gene4744 1.5e-96 360.9 Cytophagia 3.2.1.22 ko:K07407 ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603 R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091 RC00049,RC00059,RC00451 ko00000,ko00001,ko01000 Bacteria 47T8T@768503,4NFW3@976,COG3250@1,COG3250@2,COG3533@1,COG3533@2 NA|NA|NA G Beta-L-arabinofuranosidase, GH127 HIMHAPGP_01077 1123240.ATVO01000003_gene551 1.3e-146 526.2 Sphingomonadales MA20_17095 Bacteria 1MVPR@1224,2K155@204457,2TRWZ@28211,COG1680@1,COG1680@2 NA|NA|NA V Beta-lactamase HIMHAPGP_01078 1234595.C725_0882 2.6e-24 117.9 Bacteria ko:K09780 ko00000 Bacteria COG2350@1,COG2350@2 NA|NA|NA S YCII-related domain HIMHAPGP_01079 1550073.JROH01000006_gene1491 4.6e-40 170.2 Sphingomonadales rpmB GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02902 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1MZ57@1224,2K561@204457,2UBQU@28211,COG0227@1,COG0227@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL28 family HIMHAPGP_01080 1234595.C725_0928 7.1e-35 154.8 Proteobacteria Bacteria 1N7Y1@1224,COG4246@1,COG4246@2 NA|NA|NA S Protein conserved in bacteria HIMHAPGP_01082 702113.PP1Y_AT19544 7.3e-56 223.8 Sphingomonadales rsmB 2.1.1.176 ko:K03500 ko00000,ko01000,ko03009 Bacteria 1MWPE@1224,2K0U7@204457,2TSIA@28211,COG0144@1,COG0144@2 NA|NA|NA J Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family HIMHAPGP_01083 1123269.NX02_12370 2.6e-78 298.1 Sphingomonadales guaB GO:0003674,GO:0003824,GO:0003938,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 iAPECO1_1312.APECO1_4018,iECABU_c1320.ECABU_c28100,iECP_1309.ECP_2510,iECSF_1327.ECSF_2349,iUTI89_1310.UTI89_C2826,ic_1306.c3027 Bacteria 1MUJM@1224,2K0CG@204457,2TQXC@28211,COG0516@1,COG0516@2,COG0517@1,COG0517@2 NA|NA|NA F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth HIMHAPGP_01084 1123240.ATVO01000003_gene492 1.1e-100 373.6 Sphingomonadales sun GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0031974,GO:0031981,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0046483,GO:0070013,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:1901360 2.1.1.176 ko:K03500 ko00000,ko01000,ko03009 Bacteria 1MV2Q@1224,2K17G@204457,2TS6U@28211,COG0144@1,COG0144@2 NA|NA|NA J Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family HIMHAPGP_01085 685778.AORL01000021_gene762 1.9e-18 99.4 Sphingomonadales Bacteria 1R17W@1224,2KEPF@204457,2TYY0@28211,COG3063@1,COG3063@2 NA|NA|NA NU Type IV pilus biogenesis stability protein PilW HIMHAPGP_01086 1144307.PMI04_01120 8.3e-45 186.8 Sphingomonadales zur GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0008270,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010035,GO:0010038,GO:0010043,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0042221,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046872,GO:0046914,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 ko:K02076,ko:K03711,ko:K09823 ko02024,map02024 ko00000,ko00001,ko03000 Bacteria 1MZIW@1224,2K4GM@204457,2U9G4@28211,COG0735@1,COG0735@2 NA|NA|NA P Belongs to the Fur family HIMHAPGP_01087 715226.ABI_10940 3.8e-10 70.5 Caulobacterales 2.7.1.25,2.7.7.4 ko:K00860,ko:K00956 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00509,R00529,R04928,R04929 RC00002,RC00078,RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 Bacteria 1N85D@1224,2KHDV@204458,2UK2K@28211,COG3205@1,COG3205@2 NA|NA|NA S Predicted membrane protein (DUF2061) HIMHAPGP_01088 1248916.ANFY01000010_gene343 3.1e-79 301.6 Sphingomonadales ribB 3.5.4.25,4.1.99.12 ko:K02858,ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 Bacteria 1MU8P@1224,2K1FG@204457,2TSMA@28211,COG0108@1,COG0108@2 NA|NA|NA H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate HIMHAPGP_01089 745310.G432_11090 7.3e-47 193.4 Sphingomonadales ribH GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 Bacteria 1RD9J@1224,2K4FR@204457,2U9IZ@28211,COG0054@1,COG0054@2 NA|NA|NA H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin HIMHAPGP_01091 1331060.RLDS_19960 7e-304 1049.3 Sphingomonadales lepA GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0006950,GO:0006970,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009268,GO:0009409,GO:0009628,GO:0009651,GO:0009987,GO:0010467,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0042802,GO:0043021,GO:0043023,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0050896,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K03596 ko05134,map05134 ko00000,ko00001 Bacteria 1MVZA@1224,2K17X@204457,2TR3H@28211,COG0481@1,COG0481@2 NA|NA|NA M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner HIMHAPGP_01092 1248916.ANFY01000013_gene1924 1.2e-82 313.2 Sphingomonadales Bacteria 1R413@1224,2KDTR@204457,2TW0W@28211,COG1028@1,COG1028@2 NA|NA|NA IQ Short-chain dehydrogenase reductase sdr HIMHAPGP_01093 1127673.GLIP_1160 7.9e-49 200.7 Gammaproteobacteria Bacteria 1N0PI@1224,1SRAI@1236,2EN5S@1,33FTP@2 NA|NA|NA HIMHAPGP_01094 629773.AORY01000005_gene2851 4.1e-44 184.9 Sphingomonadales ko:K09125 ko00000 Bacteria 1RJV6@1224,2K2CH@204457,2U7IX@28211,COG1738@1,COG1738@2 NA|NA|NA S Involved in the import of queuosine (Q) precursors, required for Q precursor salvage HIMHAPGP_01095 1121123.AUAO01000007_gene2003 3.1e-110 405.6 Caulobacterales norM ko:K03327 ko00000,ko02000 2.A.66.1 Bacteria 1MUAM@1224,2KFPY@204458,2TSDU@28211,COG0534@1,COG0534@2 NA|NA|NA V MATE efflux family protein HIMHAPGP_01096 452662.SJA_C1-33540 2.9e-27 127.5 Sphingomonadales Bacteria 1N77J@1224,2K5Z1@204457,2UFX6@28211,COG3750@1,COG3750@2 NA|NA|NA S Belongs to the UPF0335 family HIMHAPGP_01097 1123240.ATVO01000005_gene1717 2.4e-54 218.4 Sphingomonadales coxS 1.2.5.3,1.3.99.16 ko:K03518,ko:K07302 R11168 RC02800 ko00000,ko01000 Bacteria 1MY3F@1224,2K11H@204457,2TRGH@28211,COG2080@1,COG2080@2 NA|NA|NA C aerobic-type carbon monoxide dehydrogenase, small subunit CoxS HIMHAPGP_01098 1248916.ANFY01000011_gene1075 1.4e-80 306.2 Alphaproteobacteria coxM 1.2.5.3 ko:K03519 R11168 RC02800 ko00000,ko01000 Bacteria 1MUDB@1224,2TRA8@28211,COG1319@1,COG1319@2 NA|NA|NA C Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM HIMHAPGP_01099 1207055.C100_09875 2.1e-97 362.1 Sphingomonadales yebC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 Bacteria 1MW3X@1224,2K0KW@204457,2TRSK@28211,COG0217@1,COG0217@2 NA|NA|NA K transcriptional regulatory protein HIMHAPGP_01100 1248916.ANFY01000011_gene1071 7.7e-45 186.8 Sphingomonadales ruvC GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 ko:K01159 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 1MUJI@1224,2K4Q1@204457,2U70Z@28211,COG0817@1,COG0817@2,COG2852@1,COG2852@2 NA|NA|NA L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group HIMHAPGP_01101 745310.G432_11960 5e-49 201.1 Sphingomonadales ruvA GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 ko:K03550 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 1MWJR@1224,2K2JA@204457,2TSKM@28211,COG0632@1,COG0632@2 NA|NA|NA L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB HIMHAPGP_01102 555793.WSK_3834 2.4e-266 924.9 Sphingomonadales prrA ko:K02014 ko00000,ko02000 1.B.14 Bacteria 1MXY7@1224,2K02M@204457,2TV9S@28211,COG1629@1,COG4771@2 NA|NA|NA P receptor HIMHAPGP_01103 1123269.NX02_05045 8e-205 719.9 Sphingomonadales gatB GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.12,6.3.5.6,6.3.5.7 ko:K01876,ko:K02434 ko00970,ko01100,map00970,map01100 M00359,M00360 R03905,R04212,R05577 RC00010,RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 Bacteria 1MUKG@1224,2K04H@204457,2TRHX@28211,COG0064@1,COG0064@2 NA|NA|NA J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) HIMHAPGP_01104 658612.MD26_18545 2.1e-119 437.6 Gammaproteobacteria Bacteria 1QK4F@1224,1RPAG@1236,COG1020@1,COG1020@2 NA|NA|NA Q COG1020 Non-ribosomal peptide synthetase modules and related proteins HIMHAPGP_01105 990285.RGCCGE502_23305 1.2e-96 360.9 Rhizobiaceae Bacteria 1MWJ6@1224,2U11C@28211,4BCQR@82115,COG0318@1,COG0318@2,COG1835@1,COG1835@2 NA|NA|NA IQ AMP-binding enzyme HIMHAPGP_01106 391600.ABRU01000050_gene318 2.7e-100 372.5 Caulobacterales Bacteria 1MVID@1224,2KGG2@204458,2TUR0@28211,COG1301@1,COG1301@2 NA|NA|NA C Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family HIMHAPGP_01108 190650.CC_0940 1.5e-84 319.3 Caulobacterales ko:K06978 ko00000 Bacteria 1MVA8@1224,2KK0Z@204458,2TU0R@28211,COG2936@1,COG2936@2 NA|NA|NA S X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain HIMHAPGP_01109 338969.Rfer_4204 9.5e-191 673.3 Comamonadaceae 6.2.1.48 ko:K02182 ko00000,ko01000 Bacteria 1MWSD@1224,2VJYZ@28216,4AC18@80864,COG0318@1,COG0318@2 NA|NA|NA IQ PFAM AMP-dependent synthetase and ligase HIMHAPGP_01110 748247.AZKH_1895 5e-95 354.8 Betaproteobacteria Bacteria 1MVI3@1224,2VQB7@28216,COG3268@1,COG3268@2 NA|NA|NA S Saccharopine dehydrogenase NADP binding domain HIMHAPGP_01111 279238.Saro_2969 6e-129 467.6 Sphingomonadales Bacteria 1MXAM@1224,2C3QV@1,2K063@204457,2U1FE@28211,2Z7YP@2 NA|NA|NA HIMHAPGP_01112 1248916.ANFY01000004_gene1801 1.8e-91 342.4 Sphingomonadales 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 Bacteria 1N4N7@1224,2K1V0@204457,2TS6T@28211,COG1024@1,COG1024@2 NA|NA|NA I enoyl-CoA hydratase HIMHAPGP_01113 745310.G432_08170 6e-153 547.4 Sphingomonadales Bacteria 1MVAF@1224,2K0Q2@204457,2TTYC@28211,COG1228@1,COG1228@2 NA|NA|NA Q COG1228 Imidazolonepropionase and related amidohydrolases HIMHAPGP_01114 1123240.ATVO01000005_gene2085 6.6e-61 240.0 Sphingomonadales rpsL GO:0000372,GO:0000375,GO:0000376,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008380,GO:0009058,GO:0009059,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010604,GO:0010628,GO:0015935,GO:0016070,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0031323,GO:0031325,GO:0032991,GO:0033120,GO:0034336,GO:0034337,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043484,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990145,GO:1990904 ko:K02950 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1RCWY@1224,2K3W8@204457,2U70K@28211,COG0048@1,COG0048@2 NA|NA|NA J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit HIMHAPGP_01115 5147.XP_003343011.1 2.7e-66 258.1 Opisthokonta GO:0000028,GO:0000313,GO:0000314,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005761,GO:0005763,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0031974,GO:0032543,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0065003,GO:0070013,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0098798,GO:0140053,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02992 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Opisthokonta 38HF4@33154,COG0049@1,KOG3291@2759 NA|NA|NA J ribosomal small subunit assembly HIMHAPGP_01116 1234595.C725_1967 1.7e-40 171.8 unclassified Alphaproteobacteria rpoD GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141 ko:K03086 ko00000,ko03021 Bacteria 1MVNJ@1224,2TS6C@28211,4BPAY@82117,COG0568@1,COG0568@2 NA|NA|NA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth HIMHAPGP_01117 1248916.ANFY01000009_gene180 8e-19 100.9 Sphingomonadales Bacteria 1P7WC@1224,2BNRZ@1,2K7ZC@204457,2UY2U@28211,32HFG@2 NA|NA|NA HIMHAPGP_01118 1219049.SP5_026_00060 6.3e-141 508.1 Sphingomonadales Bacteria 1R1WX@1224,2K1DC@204457,2U0GK@28211,COG4206@1,COG4206@2 NA|NA|NA H receptor HIMHAPGP_01119 1549858.MC45_13195 2.8e-49 201.8 Sphingomonadales ydjA Bacteria 1PKUV@1224,2K422@204457,2U5MZ@28211,COG0778@1,COG0778@2 NA|NA|NA C nitroreductase HIMHAPGP_01120 745411.B3C1_05357 4e-10 71.6 unclassified Gammaproteobacteria Bacteria 1JBDU@118884,1QQT2@1224,1RTGS@1236,2C79Y@1,315F1@2 NA|NA|NA HIMHAPGP_01121 1335760.ASTG01000001_gene2868 1.8e-181 642.9 Sphingomonadales gspD ko:K02453,ko:K02666,ko:K03219 ko03070,ko05111,map03070,map05111 M00331,M00332,M00542 ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2,3.A.6.1,3.A.6.3 Bacteria 1MUUA@1224,2K22S@204457,2TT8A@28211,COG1450@1,COG1450@2,COG4796@1,COG4796@2 NA|NA|NA NU Type II secretion system protein D HIMHAPGP_01122 1114964.L485_19465 8.1e-17 94.0 Sphingomonadales gspC ko:K02452 ko03070,ko05111,map03070,map05111 M00331 ko00000,ko00001,ko00002,ko02044 3.A.15 Bacteria 1RFDB@1224,2K0SG@204457,2U64N@28211,COG3031@1,COG3031@2 NA|NA|NA U Type II secretory pathway component PulC HIMHAPGP_01123 1123269.NX02_13365 1.7e-59 236.1 Sphingomonadales gspO 3.4.23.43 ko:K02464,ko:K02654 ko03070,map03070 M00331 ko00000,ko00001,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15,3.A.15.2 Bacteria 1MUZF@1224,2K2UB@204457,2UAW0@28211,COG1989@1,COG1989@2 NA|NA|NA NOU Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue HIMHAPGP_01124 1007104.SUS17_2047 5.1e-155 554.3 Sphingomonadales gltX1 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 Bacteria 1MUCR@1224,2K0M4@204457,2TRCI@28211,COG0008@1,COG0008@2 NA|NA|NA J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) HIMHAPGP_01125 1120705.FG95_00094 1.7e-08 65.9 Sphingomonadales Bacteria 1NEIW@1224,2FB68@1,2K5XN@204457,2UGH0@28211,343CI@2 NA|NA|NA HIMHAPGP_01126 1030157.AFMP01000016_gene2494 1.1e-77 296.6 Sphingomonadales gloB GO:0003674,GO:0003824,GO:0004416,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0034641,GO:0043603,GO:0044237,GO:0051186,GO:0071704,GO:1901564 3.1.2.6 ko:K01069 ko00620,map00620 R01736 RC00004,RC00137 ko00000,ko00001,ko01000 Bacteria 1MU8Q@1224,2K0DY@204457,2TSVS@28211,COG0491@1,COG0491@2 NA|NA|NA S Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid HIMHAPGP_01127 1123240.ATVO01000005_gene1939 8.8e-61 239.6 Sphingomonadales gloA GO:0003674,GO:0003824,GO:0004462,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016846,GO:0034641,GO:0043603,GO:0044237,GO:0051186,GO:0071704,GO:1901564 4.4.1.5 ko:K01759 ko00620,map00620 R02530 RC00004,RC00740 ko00000,ko00001,ko01000 Bacteria 1RCYX@1224,2K4E9@204457,2U7A8@28211,COG0346@1,COG0346@2 NA|NA|NA E COG0346 Lactoylglutathione lyase and related lyases HIMHAPGP_01128 1123240.ATVO01000005_gene1940 8e-47 193.4 Sphingomonadales ysmA ko:K07107 ko00000,ko01000 Bacteria 1MYY1@1224,2K5TX@204457,2U4W3@28211,COG0824@1,COG0824@2 NA|NA|NA S Thioesterase-like superfamily HIMHAPGP_01129 1335760.ASTG01000017_gene3449 6.7e-53 214.2 Sphingomonadales ko:K09797 ko00000 Bacteria 1QU0K@1224,2K0TS@204457,2U5D2@28211,COG2859@1,COG2859@2 NA|NA|NA S Protein of unknown function (DUF541) HIMHAPGP_01130 627192.SLG_17990 1e-70 273.1 Sphingomonadales dusB ko:K05540 ko00000,ko01000,ko03016 Bacteria 1MV5V@1224,2K0QH@204457,2TRC8@28211,COG0042@1,COG0042@2 NA|NA|NA J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines HIMHAPGP_01131 1123240.ATVO01000003_gene225 3.3e-194 685.3 Sphingomonadales ntrY GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.13.3 ko:K13598 ko02020,map02020 M00498 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 1MWKZ@1224,2K01N@204457,2TQTB@28211,COG5000@1,COG5000@2 NA|NA|NA T Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation HIMHAPGP_01132 1030157.AFMP01000011_gene3774 9.7e-189 666.4 Sphingomonadales ntrX ko:K02481,ko:K13599 ko02020,map02020 M00498 ko00000,ko00001,ko00002,ko02022 Bacteria 1MU0N@1224,2K1KM@204457,2TQW2@28211,COG2204@1,COG2204@2 NA|NA|NA T Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains HIMHAPGP_01133 426117.M446_5942 2.6e-29 134.4 Methylobacteriaceae hfq GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0006807,GO:0008150,GO:0008152,GO:0009399,GO:0071941,GO:0097159,GO:1901363 ko:K03666 ko02024,ko03018,ko05111,map02024,map03018,map05111 ko00000,ko00001,ko03019,ko03036 Bacteria 1JV8F@119045,1MZM1@1224,2UBTW@28211,COG1923@1,COG1923@2 NA|NA|NA J RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs HIMHAPGP_01134 1123240.ATVO01000003_gene230 5.8e-138 497.7 Sphingomonadales hflX GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006464,GO:0006468,GO:0006518,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018105,GO:0018193,GO:0018209,GO:0019001,GO:0019222,GO:0019538,GO:0019843,GO:0022411,GO:0030554,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032790,GO:0032984,GO:0032988,GO:0034248,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0043021,GO:0043022,GO:0043023,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:2000112 ko:K03665 ko00000,ko03009 Bacteria 1MUA0@1224,2K0SI@204457,2TUXJ@28211,COG2262@1,COG2262@2 NA|NA|NA S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis HIMHAPGP_01135 1234595.C725_1972 2.9e-65 255.4 unclassified Alphaproteobacteria Bacteria 1MXQR@1224,2TW65@28211,4BSDZ@82117,COG1028@1,COG1028@2 NA|NA|NA IQ Enoyl-(Acyl carrier protein) reductase HIMHAPGP_01137 1123240.ATVO01000003_gene560 3.1e-49 202.2 Sphingomonadales vacJ ko:K04754 ko00000 Bacteria 1MVX0@1224,2K3Q5@204457,2U7CZ@28211,COG2853@1,COG2853@2 NA|NA|NA M Lipoprotein HIMHAPGP_01138 1081640.AGFU01000018_gene1771 7.9e-78 297.4 Sphingomonadales Bacteria 1NFSV@1224,2K0VB@204457,2TSMV@28211,COG0500@1,COG0640@1,COG0640@2,COG2226@2 NA|NA|NA K ArsR family transcriptional regulator HIMHAPGP_01139 1219045.BV98_001797 3.5e-126 458.0 Sphingomonadales metF GO:0000166,GO:0003674,GO:0003824,GO:0004489,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019438,GO:0019752,GO:0022607,GO:0034641,GO:0036094,GO:0042398,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0071949,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 iPC815.YPO0117,iSBO_1134.SBO_3961 Bacteria 1MUC9@1224,2K03Q@204457,2TQZA@28211,COG0685@1,COG0685@2 NA|NA|NA E Methylenetetrahydrofolate reductase HIMHAPGP_01140 1123240.ATVO01000003_gene557 8.6e-137 493.4 Sphingomonadales metH GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 iECO103_1326.ECO103_4764,iECUMN_1333.ECUMN_4545 Bacteria 1NPFY@1224,2K10F@204457,2UJRS@28211,COG0646@1,COG0646@2 NA|NA|NA E Methionine synthase I (cobalamin-dependent), methyltransferase domain HIMHAPGP_01141 1122970.AUHC01000002_gene1423 4.3e-193 681.0 Sphingomonadales metH GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 Bacteria 1MV6G@1224,2K0JK@204457,2TQTG@28211,COG1410@1,COG1410@2 NA|NA|NA E 5-methyltetrahydrofolate--homocysteine methyltransferase HIMHAPGP_01142 1292034.OR37_02421 1.9e-43 182.6 Caulobacterales MA20_36340 Bacteria 1N8EV@1224,2KGJ5@204458,2TTNV@28211,COG0494@1,COG0494@2 NA|NA|NA L COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes HIMHAPGP_01143 1090318.ATTI01000001_gene100 2.6e-93 348.2 Sphingomonadales rnd 3.1.13.5 ko:K03684 ko00000,ko01000,ko03016 Bacteria 1MWFD@1224,2K0FG@204457,2TQXS@28211,COG0349@1,COG0349@2 NA|NA|NA L 3'-5' exonuclease HIMHAPGP_01144 1123240.ATVO01000010_gene616 6.9e-44 184.1 Sphingomonadales ko:K11719 ko00000,ko02000 1.B.42.1 Bacteria 1NMV8@1224,2K34V@204457,2VCS4@28211,COG5375@1,COG5375@2 NA|NA|NA S Protein conserved in bacteria HIMHAPGP_01145 1123267.JONN01000001_gene2243 2.5e-36 158.7 Sphingomonadales lptA GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0009279,GO:0010876,GO:0015920,GO:0016020,GO:0017089,GO:0019867,GO:0030288,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0042597,GO:0042802,GO:0044462,GO:0044464,GO:0046836,GO:0051179,GO:0051234,GO:0071702,GO:0071944,GO:1901264 ko:K09774 ko00000,ko02000 1.B.42.1 iB21_1397.B21_03016,iECBD_1354.ECBD_0542,iECB_1328.ECB_03065,iECD_1391.ECD_03065 Bacteria 1MXGA@1224,2K3YP@204457,2U6DD@28211,COG1934@1,COG1934@2 NA|NA|NA S protein conserved in bacteria HIMHAPGP_01146 1123240.ATVO01000006_gene1624 3.2e-69 268.5 Sphingomonadales ubiG GO:0003674,GO:0003824,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008289,GO:0008689,GO:0008757,GO:0009058,GO:0009108,GO:0009628,GO:0009651,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0042180,GO:0042181,GO:0042538,GO:0043167,GO:0043168,GO:0043431,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0051188,GO:0061542,GO:0071704,GO:1901576,GO:1901611,GO:1901661,GO:1901663 2.1.1.222,2.1.1.64 ko:K00568 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04988,R05614,R08769,R08781 RC00003,RC00392,RC01895 ko00000,ko00001,ko00002,ko01000 iE2348C_1286.E2348C_2376 Bacteria 1MU89@1224,2K0DH@204457,2TRIK@28211,COG2227@1,COG2227@2 NA|NA|NA H O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway HIMHAPGP_01147 392499.Swit_2393 3.6e-90 338.2 Sphingomonadales ate GO:0003674,GO:0003824,GO:0004057,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016598,GO:0016740,GO:0016746,GO:0016755,GO:0019538,GO:0019941,GO:0030163,GO:0036211,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575 2.3.2.29 ko:K21420 R11547,R11548 RC00064 ko00000,ko01000 Bacteria 1MW62@1224,2K00M@204457,2TQY8@28211,COG2935@1,COG2935@2 NA|NA|NA O May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate HIMHAPGP_01148 1123240.ATVO01000005_gene1870 1.7e-168 599.0 Sphingomonadales ilvA 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 iLJ478.TM0356 Bacteria 1MVWJ@1224,2K130@204457,2TQN9@28211,COG1171@1,COG1171@2 NA|NA|NA E Threonine dehydratase HIMHAPGP_01149 1234595.C725_2530 7.5e-88 330.5 unclassified Alphaproteobacteria mmsB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006520,GO:0006573,GO:0006574,GO:0006807,GO:0008150,GO:0008152,GO:0008442,GO:0009056,GO:0009063,GO:0009081,GO:0009083,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0031974,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0055114,GO:0070013,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.1.1.31,1.1.1.60 ko:K00020,ko:K00042 ko00280,ko00630,ko01100,map00280,map00630,map01100 R01745,R01747,R05066 RC00099 ko00000,ko00001,ko01000 Bacteria 1MUGU@1224,2TT50@28211,4BPMX@82117,COG2084@1,COG2084@2 NA|NA|NA I PFAM NAD binding domain of 6-phosphogluconate dehydrogenase HIMHAPGP_01150 745310.G432_16060 7.1e-162 577.4 Sphingomonadales Bacteria 1MWP2@1224,2K1UV@204457,2TTRU@28211,COG1574@1,COG1574@2 NA|NA|NA S Metal-dependent hydrolase HIMHAPGP_01151 1248916.ANFY01000003_gene1031 2e-60 239.2 Sphingomonadales Bacteria 1QUNR@1224,2K1AC@204457,2TW24@28211,COG0300@1,COG0300@2 NA|NA|NA S COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) HIMHAPGP_01152 1248916.ANFY01000003_gene1032 8.2e-51 206.5 Sphingomonadales purF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009507,GO:0009536,GO:0040007,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 iSB619.SA_RS05225 Bacteria 1MU0V@1224,2K0C0@204457,2TR8V@28211,COG0034@1,COG0034@2 NA|NA|NA F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine HIMHAPGP_01153 745310.G432_11815 4.8e-140 504.6 Sphingomonadales pmbA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564 ko:K03592 ko00000,ko01002 Bacteria 1MUVW@1224,2K048@204457,2TSAV@28211,COG0312@1,COG0312@2 NA|NA|NA S modulator of DNA gyrase HIMHAPGP_01154 1248916.ANFY01000007_gene2609 7.3e-77 294.3 Sphingomonadales ko:K03593 ko00000,ko03029,ko03036 Bacteria 1MU7R@1224,2K1RH@204457,2TRDM@28211,COG0489@1,COG0489@2 NA|NA|NA D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP HIMHAPGP_01155 1123240.ATVO01000009_gene784 1.1e-92 347.1 Sphingomonadales hflK ko:K04088 M00742 ko00000,ko00002,ko01000 Bacteria 1MUM2@1224,2K20N@204457,2TRTP@28211,COG0330@1,COG0330@2 NA|NA|NA O HflC and HflK could encode or regulate a protease HIMHAPGP_01156 1248916.ANFY01000007_gene2607 1.6e-85 322.8 Sphingomonadales hflC ko:K04087 M00742 ko00000,ko00002,ko01000 Bacteria 1MV7R@1224,2K1HR@204457,2TRP4@28211,COG0330@1,COG0330@2 NA|NA|NA O HflC and HflK could regulate a protease HIMHAPGP_01158 1522072.IL54_4397 2.5e-17 95.5 Proteobacteria Bacteria 1P9RC@1224,2ZTA6@2,COG1258@1 NA|NA|NA J pseudouridine synthase activity HIMHAPGP_01159 1123269.NX02_22880 5.1e-102 377.5 Sphingomonadales nadB GO:0000166,GO:0001716,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008734,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0015922,GO:0016491,GO:0016638,GO:0016641,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044318,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605 1.3.5.4,1.4.3.16 ko:K00244,ko:K00278 ko00020,ko00190,ko00250,ko00620,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00250,map00620,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00115,M00150,M00173 R00357,R00481,R02164 RC00006,RC00045,RC02566 ko00000,ko00001,ko00002,ko01000 iAF1260.b2574,iBWG_1329.BWG_2338,iECDH10B_1368.ECDH10B_2742,iECDH1ME8569_1439.ECDH1ME8569_2501,iETEC_1333.ETEC_2787,iEcDH1_1363.EcDH1_1094,iJN678.nadB,iJO1366.b2574,iJR904.b2574,iLF82_1304.LF82_1433,iNRG857_1313.NRG857_12785,iSbBS512_1146.nadB,iY75_1357.Y75_RS13445,iYL1228.KPN_02899 Bacteria 1RBQW@1224,2JZXW@204457,2TS0E@28211,COG0029@1,COG0029@2 NA|NA|NA H Catalyzes the oxidation of L-aspartate to iminoaspartate HIMHAPGP_01160 1144307.PMI04_01673 3.1e-15 88.2 Sphingomonadales Bacteria 1NHQU@1224,2E2R2@1,2K6HA@204457,2UKPG@28211,32XTN@2 NA|NA|NA S MerC mercury resistance protein HIMHAPGP_01161 1248916.ANFY01000005_gene2751 1.7e-93 349.7 Sphingomonadales ycbL GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019243,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0051596,GO:0061727,GO:0071704,GO:1901575,GO:1901615 3.1.2.6 ko:K01069 ko00620,map00620 R01736 RC00004,RC00137 ko00000,ko00001,ko01000 Bacteria 1MUDN@1224,2K19S@204457,2TQJ9@28211,COG0491@1,COG0491@2 NA|NA|NA S COG0491 Zn-dependent hydrolases, including glyoxylases HIMHAPGP_01162 392499.Swit_1486 3.1e-88 331.6 Sphingomonadales Bacteria 1N0A9@1224,2K2YU@204457,2TTMN@28211,COG0457@1,COG0457@2 NA|NA|NA S COG0457 FOG TPR repeat HIMHAPGP_01163 1030157.AFMP01000031_gene2896 3.3e-146 524.6 Sphingomonadales nadA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 iAF1260.b0750,iAPECO1_1312.APECO1_1338,iB21_1397.B21_00692,iBWG_1329.BWG_0602,iECBD_1354.ECBD_2917,iECB_1328.ECB_00703,iECDH10B_1368.ECDH10B_0817,iECDH1ME8569_1439.ECDH1ME8569_0703,iECD_1391.ECD_00703,iECED1_1282.ECED1_0711,iECOK1_1307.ECOK1_0750,iECP_1309.ECP_0761,iECS88_1305.ECS88_0766,iECSP_1301.ECSP_0802,iECs_1301.ECs0778,iETEC_1333.ETEC_0754,iEcDH1_1363.EcDH1_2892,iEcolC_1368.EcolC_2912,iJN746.PP_1231,iJO1366.b0750,iJR904.b0750,iUMN146_1321.UM146_13905,iUTI89_1310.UTI89_C0747,iY75_1357.Y75_RS03905,iZ_1308.Z0919 Bacteria 1MWQU@1224,2K13Q@204457,2TRPG@28211,COG0379@1,COG0379@2 NA|NA|NA H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate HIMHAPGP_01166 1234595.C725_1076 2.9e-22 112.1 Alphaproteobacteria Bacteria 1N3B4@1224,2C2VU@1,2UCFR@28211,34305@2 NA|NA|NA HIMHAPGP_01167 414684.RC1_0309 6.1e-07 61.2 Alphaproteobacteria Bacteria 1REP3@1224,2UJB6@28211,COG1309@1,COG1309@2 NA|NA|NA K transcriptional regulator HIMHAPGP_01168 1090320.KB900605_gene2897 1.6e-80 305.4 Sphingomonadales moxR GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 ko:K03924 ko00000,ko01000 Bacteria 1MV5I@1224,2JZXF@204457,2TRI8@28211,COG0714@1,COG0714@2 NA|NA|NA S ATPase AAA HIMHAPGP_01169 392499.Swit_2429 1.9e-38 164.9 Sphingomonadales pheS GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iJN746.PP_2469,iSSON_1240.SSON_1444,iYL1228.KPN_02176 Bacteria 1MVD7@1224,2K0XB@204457,2TS2T@28211,COG0016@1,COG0016@2 NA|NA|NA J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily HIMHAPGP_01170 745310.G432_00500 2.8e-168 598.2 Sphingomonadales Bacteria 1MU2K@1224,2K3P7@204457,2TSF6@28211,COG1804@1,COG1804@2 NA|NA|NA C CoA-transferase family III HIMHAPGP_01171 1248760.ANFZ01000012_gene44 3.8e-194 684.1 Sphingomonadales bcd 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 Bacteria 1MUDR@1224,2K0AS@204457,2TR78@28211,COG1960@1,COG1960@2 NA|NA|NA I Acyl-CoA dehydrogenase, C-terminal domain HIMHAPGP_01172 745310.G432_00490 1.1e-78 299.3 Sphingomonadales 4.2.1.56 ko:K18290 ko00660,map00660 R02491 RC00730 ko00000,ko00001,ko01000 Bacteria 1MW4N@1224,2K2HP@204457,2TQQ2@28211,COG2030@1,COG2030@2 NA|NA|NA I MaoC like domain HIMHAPGP_01173 745310.G432_00485 9.2e-81 307.0 Sphingomonadales citE 4.1.3.25,4.1.3.34 ko:K01644,ko:K18292 ko00660,ko01100,ko02020,map00660,map01100,map02020 R00237,R00362 RC00067,RC00502,RC01118,RC01205 ko00000,ko00001,ko01000 Bacteria 1MW0A@1224,2K6FJ@204457,2TTC0@28211,COG2301@1,COG2301@2 NA|NA|NA G C-C_Bond_Lyase of the TIM-Barrel fold HIMHAPGP_01174 745310.G432_00480 7.9e-83 313.5 Sphingomonadales Bacteria 1RFVJ@1224,2BFHU@1,2K1CV@204457,2U8MF@28211,329BM@2 NA|NA|NA HIMHAPGP_01175 1248760.ANFZ01000012_gene40 1.4e-310 1072.0 Sphingomonadales ko:K02014 ko00000,ko02000 1.B.14 Bacteria 1QTXJ@1224,2K0KJ@204457,2TZ62@28211,COG4773@1,COG4773@2 NA|NA|NA P TonB dependent receptor HIMHAPGP_01176 745310.G432_00470 1.5e-156 559.3 Sphingomonadales Bacteria 1QVY6@1224,2KEFC@204457,2TWTV@28211,COG2271@1,COG2271@2 NA|NA|NA G Major facilitator superfamily HIMHAPGP_01181 1248916.ANFY01000009_gene221 2e-69 269.2 Sphingomonadales pssA GO:0003674,GO:0003824,GO:0003882,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 Bacteria 1MWD9@1224,2K1B9@204457,2TUF7@28211,COG1183@1,COG1183@2 NA|NA|NA I Belongs to the CDP-alcohol phosphatidyltransferase class-I family HIMHAPGP_01182 1234595.C725_2001 1.3e-76 293.1 unclassified Alphaproteobacteria psd GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 Bacteria 1MW45@1224,2TRMG@28211,4BQ3A@82117,COG0688@1,COG0688@2 NA|NA|NA I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) HIMHAPGP_01183 59538.XP_005981514.1 5.8e-122 444.1 Cetartiodactyla Mammalia 38GT8@33154,3BBXC@33208,3CTTZ@33213,3J4V3@40674,484CS@7711,4915I@7742,4J0IC@91561,COG1612@1,KOG2725@2759 NA|NA|NA O cytochrome c oxidase assembly HIMHAPGP_01184 745310.G432_13995 1.6e-25 122.1 Sphingomonadales cutA GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0010035,GO:0010038,GO:0016043,GO:0022607,GO:0042221,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0046688,GO:0046872,GO:0046914,GO:0050896,GO:0051259,GO:0051260,GO:0065003,GO:0071840 4.2.3.1 ko:K01733,ko:K03926 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 Bacteria 1N6TN@1224,2K75D@204457,2UF5Y@28211,COG1324@1,COG1324@2 NA|NA|NA P CutA1 divalent ion tolerance protein HIMHAPGP_01185 1449076.JOOE01000002_gene1431 3.5e-69 267.7 Sphingomonadales rplM GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0070180,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 ko:K02871 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1RA11@1224,2K28X@204457,2U5FM@28211,COG0102@1,COG0102@2 NA|NA|NA J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly HIMHAPGP_01186 579138.Zymop_0384 7.7e-60 236.9 Sphingomonadales rpsI GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02996 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1RD4A@1224,2K0C7@204457,2U5B5@28211,COG0103@1,COG0103@2 NA|NA|NA J Belongs to the universal ribosomal protein uS9 family HIMHAPGP_01187 1123240.ATVO01000005_gene1860 2.7e-179 635.6 Sphingomonadales dsbD 1.8.1.8 ko:K04084 ko00000,ko01000,ko03110 5.A.1.1 Bacteria 1MU8W@1224,2K11D@204457,2TTUM@28211,COG4232@1,COG4232@2,COG4233@1,COG4233@2 NA|NA|NA CO Thiol disulfide interchange protein HIMHAPGP_01188 745310.G432_16400 1e-54 219.9 Sphingomonadales Bacteria 1RD2X@1224,2K8KP@204457,2U7PM@28211,COG1225@1,COG1225@2 NA|NA|NA O Redoxin HIMHAPGP_01189 1123269.NX02_11705 6.2e-56 223.4 Sphingomonadales aspS 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 Bacteria 1MUXB@1224,2K0PT@204457,2TR9U@28211,COG0173@1,COG0173@2 NA|NA|NA J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) HIMHAPGP_01190 1234595.C725_0483 4e-125 454.9 Alphaproteobacteria 6.2.1.42 ko:K00666,ko:K18688 ko00000,ko01000,ko01004 Bacteria 1MVJ1@1224,2TUQ9@28211,COG0318@1,COG0318@2 NA|NA|NA IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II HIMHAPGP_01191 1030157.AFMP01000014_gene3429 8.1e-138 498.0 Sphingomonadales 2.7.13.3 ko:K02484,ko:K11206,ko:K11383 ko02020,map02020 M00505 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 1MUHS@1224,2K18N@204457,2U2TE@28211,COG4252@1,COG4252@2,COG5002@1,COG5002@2 NA|NA|NA T signal transduction histidine kinase HIMHAPGP_01192 1030157.AFMP01000014_gene3428 1.2e-56 228.0 Sphingomonadales Bacteria 1NKA2@1224,2K154@204457,2U53E@28211,COG1388@1,COG1388@2,COG4254@1,COG4254@2 NA|NA|NA M Lysin motif HIMHAPGP_01193 392499.Swit_4742 5.6e-63 247.7 Sphingomonadales Bacteria 1RBJ1@1224,2K46Z@204457,2U6DI@28211,COG0745@1,COG0745@2 NA|NA|NA K Two component transcriptional regulator HIMHAPGP_01194 450851.PHZ_c2064 6.2e-25 119.8 Alphaproteobacteria 5.99.1.2 ko:K03169 ko00000,ko01000,ko03032 Bacteria 1N3MD@1224,2UC9T@28211,COG5531@1,COG5531@2 NA|NA|NA B PFAM SWIB MDM2 domain HIMHAPGP_01195 745310.G432_13910 3.5e-91 341.7 Sphingomonadales xerD GO:0000150,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009314,GO:0009628,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0071139,GO:0071704,GO:0090304,GO:0140097,GO:1901360 ko:K03733,ko:K04763 ko00000,ko03036 Bacteria 1MVNF@1224,2K25K@204457,2TRAA@28211,COG4974@1,COG4974@2 NA|NA|NA L Belongs to the 'phage' integrase family HIMHAPGP_01196 1248916.ANFY01000003_gene456 1.7e-110 406.0 Sphingomonadales 3.1.1.17 ko:K01053 ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220 M00129 R01519,R02933,R03751 RC00537,RC00983 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1MXVD@1224,2K1RT@204457,2TVCW@28211,COG3386@1,COG3386@2 NA|NA|NA G SMP-30/Gluconolaconase/LRE-like region HIMHAPGP_01197 1248916.ANFY01000003_gene582 2.3e-105 389.4 Sphingomonadales rmuC ko:K09760 ko00000 Bacteria 1MWHV@1224,2K0B3@204457,2TTX6@28211,COG1322@1,COG1322@2 NA|NA|NA S DNA recombination protein HIMHAPGP_01198 1030157.AFMP01000016_gene2375 4.3e-77 294.3 Sphingomonadales hisB GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0004424,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042578,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23,2.6.1.9,3.1.3.15,4.2.1.19 ko:K00013,ko:K00817,ko:K01089,ko:K01693 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R01158,R01163,R03012,R03013,R03243,R03457 RC00006,RC00017,RC00099,RC00242,RC00463,RC00888,RC00932 ko00000,ko00001,ko00002,ko01000,ko01007 iECO111_1330.ECO111_2746,iECS88_1305.ECS88_2121,iJN746.PP_0289,iLJ478.TM1039,iSB619.SA_RS14130,iUMNK88_1353.UMNK88_2570 Bacteria 1MWBS@1224,2K1TW@204457,2TTVV@28211,COG0131@1,COG0131@2 NA|NA|NA E Imidazoleglycerol-phosphate dehydratase HIMHAPGP_01199 1030157.AFMP01000016_gene2376 1.6e-63 249.2 Sphingomonadales hisH GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 Bacteria 1MU4X@1224,2K223@204457,2TTT4@28211,COG0118@1,COG0118@2 NA|NA|NA E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR HIMHAPGP_01200 685035.ADAE01000008_gene3002 1.2e-84 319.7 Sphingomonadales hisA GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_0388 Bacteria 1MW6S@1224,2K0CJ@204457,2TRSG@28211,COG0106@1,COG0106@2 NA|NA|NA E 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase HIMHAPGP_01201 392499.Swit_2720 2.8e-97 361.7 Sphingomonadales hisF GO:0000107,GO:0003674,GO:0003824,GO:0008150,GO:0016740,GO:0016757,GO:0016763,GO:0040007 4.1.3.27 ko:K01657,ko:K02500 ko00340,ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00340,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023,M00026 R00985,R00986,R04558 RC00010,RC01190,RC01943,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUS0@1224,2K1KV@204457,2TQXD@28211,COG0107@1,COG0107@2 NA|NA|NA E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit HIMHAPGP_01202 1044.EH31_05670 2.1e-22 111.7 Sphingomonadales hisE GO:0000105,GO:0000287,GO:0003674,GO:0003824,GO:0004636,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0043167,GO:0043169,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044419,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052803,GO:0071704,GO:0071944,GO:0075136,GO:0075139,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.4.19,3.6.1.31,5.3.1.16 ko:K01523,ko:K01814,ko:K11755 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035,R04037,R04640 RC00002,RC00945,RC01055 ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS14110,iYO844.BSU34860 Bacteria 1MZEE@1224,2K5ZV@204457,2UBU3@28211,COG0140@1,COG0140@2 NA|NA|NA E Phosphoribosyl-ATP HIMHAPGP_01203 1122137.AQXF01000001_gene3351 6.6e-47 193.4 Alphaproteobacteria hinT GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019478,GO:0019752,GO:0043436,GO:0043530,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046144,GO:0046395,GO:0046416,GO:0046436,GO:0055130,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.1.1.226,2.1.1.227 ko:K02503,ko:K06442 ko00000,ko01000,ko03009,ko04147 Bacteria 1RDCJ@1224,2U956@28211,COG0537@1,COG0537@2 NA|NA|NA FG COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases HIMHAPGP_01204 745310.G432_10450 6.4e-221 773.5 Sphingomonadales atrC1 ko:K03294 ko00000 2.A.3.2 Bacteria 1MXNJ@1224,2K03C@204457,2TRNX@28211,COG0531@1,COG0531@2 NA|NA|NA E amino acid HIMHAPGP_01205 279238.Saro_0237 2.9e-147 528.9 Sphingomonadales rhlE2 3.6.4.13 ko:K11927 ko03018,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 1MU49@1224,2K0U4@204457,2TR6Q@28211,COG0513@1,COG0513@2 NA|NA|NA L DEAD DEAH box helicase HIMHAPGP_01207 1248916.ANFY01000007_gene2202 9.8e-201 706.8 Sphingomonadales ko:K02014 ko00000,ko02000 1.B.14 Bacteria 1MUZG@1224,2K1AW@204457,2TUNP@28211,COG4206@1,COG4206@2 NA|NA|NA H receptor HIMHAPGP_01208 1144307.PMI04_01521 9.9e-144 516.5 Sphingomonadales ccrM 2.1.1.72 ko:K00571,ko:K13581 ko04112,map04112 ko00000,ko00001,ko01000,ko02048 Bacteria 1MX9M@1224,2K0RE@204457,2TSW9@28211,COG2189@1,COG2189@2 NA|NA|NA L Belongs to the N(4) N(6)-methyltransferase family HIMHAPGP_01209 269796.Rru_A3209 3e-27 127.9 Rhodospirillales rnhB GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 ko:K03470 ko03030,map03030 ko00000,ko00001,ko01000,ko03032 Bacteria 1RA65@1224,2JS6F@204441,2U73X@28211,COG0164@1,COG0164@2 NA|NA|NA L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids HIMHAPGP_01210 1174684.EBMC1_14595 1.1e-57 229.6 Sphingomonadales Bacteria 1MZTD@1224,2DMP1@1,2K5F0@204457,2U86W@28211,32SS8@2 NA|NA|NA S Protein of unknown function (DUF3237) HIMHAPGP_01211 1537715.JQFJ01000005_gene42 5e-35 154.1 Sphingomonadales Bacteria 1N7BN@1224,2KBD4@204457,2UINK@28211,COG1846@1,COG1846@2 NA|NA|NA K Winged helix DNA-binding domain HIMHAPGP_01212 1537715.JQFJ01000005_gene41 1.2e-249 869.0 Sphingomonadales alkK 6.2.1.44 ko:K00666,ko:K20034 ko00920,map00920 R10820 RC00004,RC00014 ko00000,ko00001,ko01000,ko01004 Bacteria 1MUMC@1224,2K0TE@204457,2TR96@28211,COG0318@1,COG0318@2 NA|NA|NA IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II HIMHAPGP_01213 450851.PHZ_c1909 2.2e-157 562.4 Caulobacterales 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 Bacteria 1MU6G@1224,2KG0T@204458,2TR2W@28211,COG0318@1,COG0318@2 NA|NA|NA IQ AMP-binding enzyme C-terminal domain HIMHAPGP_01214 1120705.FG95_02613 5.4e-67 260.4 Alphaproteobacteria Bacteria 1NC27@1224,2DMP1@1,2VGQD@28211,32SS8@2 NA|NA|NA S Protein of unknown function (DUF3237) HIMHAPGP_01215 1030157.AFMP01000062_gene3589 6.5e-55 220.7 Sphingomonadales 5.2.1.8 ko:K03767,ko:K03768 ko01503,ko04217,map01503,map04217 ko00000,ko00001,ko01000,ko03110,ko04147 Bacteria 1RGF5@1224,2K19C@204457,2U980@28211,COG0652@1,COG0652@2 NA|NA|NA M peptidyl-prolyl cis-trans isomerase HIMHAPGP_01216 1382303.JPOM01000001_gene2265 4.5e-127 461.8 Caulobacterales mnmC GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0004808,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016491,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0071949,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363 2.1.1.61,2.1.1.72,2.4.2.29,4.2.1.151 ko:K00773,ko:K07319,ko:K11782,ko:K15461 ko00130,ko01110,map00130,map01110 R00601,R03789,R08702,R10209,R10666 RC00003,RC00053,RC00060,RC00063,RC01483,RC03232 ko00000,ko00001,ko01000,ko02048,ko03016 Bacteria 1MZW5@1224,2KF4F@204458,2TUNX@28211,COG0665@1,COG0665@2,COG4121@1,COG4121@2 NA|NA|NA J Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 HIMHAPGP_01217 1408419.JHYG01000006_gene2627 2.6e-73 282.3 Rhodospirillales Bacteria 1MW16@1224,2JP9M@204441,2TRIG@28211,COG0583@1,COG0583@2 NA|NA|NA K transcriptional regulator HIMHAPGP_01218 745310.G432_11700 2.1e-91 342.0 Sphingomonadales yhhW ko:K06911 ko00000 Bacteria 1MVSW@1224,2K0PN@204457,2TSR6@28211,COG1741@1,COG1741@2 NA|NA|NA S Belongs to the pirin family HIMHAPGP_01219 1343158.SACS_0716 5.8e-74 283.9 Rhodospirillales wrbA GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114 1.6.5.2 ko:K03809 ko00130,ko01110,map00130,map01110 R02964,R03643,R03816 RC00819 ko00000,ko00001,ko01000 Bacteria 1MW7N@1224,2JQ93@204441,2TR4Z@28211,COG0655@1,COG0655@2 NA|NA|NA S Belongs to the WrbA family HIMHAPGP_01220 1211115.ALIQ01000190_gene922 4.6e-124 451.4 Alphaproteobacteria ktrB ko:K03498 ko00000,ko02000 2.A.38.1,2.A.38.4 Bacteria 1N412@1224,2TTGP@28211,COG0168@1,COG0168@2 NA|NA|NA P COG0168 Trk-type K transport systems, membrane components HIMHAPGP_01221 1211115.ALIQ01000190_gene921 8.6e-74 283.5 Alphaproteobacteria trkA ko:K03499 ko00000,ko02000 2.A.38.1,2.A.38.4 Bacteria 1R7KM@1224,2TY5D@28211,COG0569@1,COG0569@2 NA|NA|NA P COG0569 K transport systems, NAD-binding component HIMHAPGP_01222 317655.Sala_0291 2.5e-49 202.2 Sphingomonadales sodB 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 ko00000,ko00001,ko01000 Bacteria 1MVW2@1224,2K112@204457,2TU3T@28211,COG0605@1,COG0605@2 NA|NA|NA P Destroys radicals which are normally produced within the cells and which are toxic to biological systems HIMHAPGP_01223 685778.AORL01000010_gene2584 2e-202 712.2 Sphingomonadales pepP 3.4.11.9 ko:K01262,ko:K02027 M00207 ko00000,ko00002,ko01000,ko01002,ko02000 3.A.1.1 Bacteria 1MUZS@1224,2K0TU@204457,2TQXN@28211,COG0006@1,COG0006@2 NA|NA|NA E aminopeptidase HIMHAPGP_01224 1549858.MC45_15065 9.3e-83 313.9 Sphingomonadales MA20_05390 2.1.1.79 ko:K00574,ko:K18164 ko04714,map04714 ko00000,ko00001,ko01000,ko03029 Bacteria 1N3CJ@1224,2K21E@204457,2TRHW@28211,COG1565@1,COG1565@2 NA|NA|NA M Putative S-adenosyl-L-methionine-dependent methyltransferase HIMHAPGP_01225 685778.AORL01000009_gene3214 3.8e-92 344.7 Sphingomonadales lgt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008961,GO:0009249,GO:0009987,GO:0010467,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0031224,GO:0031226,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051604,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.1.1.199 ko:K03438,ko:K13292 ko00000,ko01000,ko03009 Bacteria 1MVE3@1224,2K1JZ@204457,2TTNS@28211,COG0682@1,COG0682@2 NA|NA|NA M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins HIMHAPGP_01226 1248916.ANFY01000003_gene480 9.7e-177 626.3 Sphingomonadales MA20_22780 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 Bacteria 1MVJC@1224,2K0FU@204457,2TUVB@28211,COG1960@1,COG1960@2 NA|NA|NA I Acyl-CoA dehydrogenase, middle domain HIMHAPGP_01227 1248916.ANFY01000003_gene481 1e-135 490.0 Sphingomonadales MA20_22775 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUBH@1224,2K1G8@204457,2TVBB@28211,COG1960@1,COG1960@2 NA|NA|NA I Acyl-CoA dehydrogenase, N-terminal domain HIMHAPGP_01228 1248916.ANFY01000003_gene482 2.1e-209 735.3 Sphingomonadales Bacteria 1MU6G@1224,2JZZB@204457,2TR2W@28211,COG0318@1,COG0318@2 NA|NA|NA IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II HIMHAPGP_01229 1090320.KB900605_gene1241 9.2e-31 140.2 Sphingomonadales paiA GO:0003674,GO:0003824,GO:0004145,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008080,GO:0008150,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0043937,GO:0043939,GO:0044424,GO:0044464,GO:0048519,GO:0050789,GO:0050793,GO:0051093,GO:0065007 2.3.1.57 ko:K22441 ko00000,ko01000 Bacteria 1MZA6@1224,2K4CY@204457,2UCC0@28211,COG0454@1,COG0456@2 NA|NA|NA K Acetyltransferase (GNAT) domain HIMHAPGP_01230 1550073.JROH01000006_gene1500 3.9e-75 288.1 Sphingomonadales yfiH GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016679,GO:0016682,GO:0030312,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0046983,GO:0055114,GO:0071944 ko:K05810 ko00000,ko01000 Bacteria 1MW2H@1224,2K13X@204457,2TTXU@28211,COG1496@1,COG1496@2 NA|NA|NA S Belongs to the multicopper oxidase YfiH RL5 family HIMHAPGP_01231 1248916.ANFY01000008_gene2061 5e-66 258.5 Alphaproteobacteria bamD ko:K05807,ko:K08309 ko00000,ko01000,ko01011,ko02000 1.B.33.1 GH23 Bacteria 1Q6I3@1224,2URPB@28211,COG4105@1,COG4105@2 NA|NA|NA S Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HIMHAPGP_01232 685778.AORL01000021_gene561 5e-104 384.4 Sphingomonadales fabD GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 iEcE24377_1341.EcE24377A_1213,iJN746.PP_1913,iPC815.YPO1598 Bacteria 1MV6N@1224,2K15H@204457,2TRTT@28211,COG0331@1,COG0331@2 NA|NA|NA I malonyl CoA-acyl carrier protein transacylase HIMHAPGP_01233 272630.MexAM1_META1p0377 2.4e-85 322.0 Methylobacteriaceae Bacteria 1JSKJ@119045,1MU6X@1224,2TQZG@28211,COG1028@1,COG1028@2 NA|NA|NA IQ Short-chain dehydrogenase reductase SDR HIMHAPGP_01234 633131.TR2A62_0426 1.1e-31 142.1 Alphaproteobacteria acpP GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 ko:K02078 ko00000,ko00001 Bacteria 1MZ4P@1224,2UBWW@28211,COG0236@1,COG0236@2 NA|NA|NA IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis HIMHAPGP_01235 1125973.JNLC01000001_gene47 1.4e-51 209.9 Bradyrhizobiaceae yreE Bacteria 1PX74@1224,2TUV9@28211,3JV4I@41294,COG0671@1,COG0671@2 NA|NA|NA I LssY C-terminus HIMHAPGP_01236 83219.PM02_09935 2.4e-42 178.7 Sulfitobacter Bacteria 1RHBD@1224,2U925@28211,3ZX25@60136,COG1670@1,COG1670@2 NA|NA|NA J Acetyltransferase (GNAT) domain HIMHAPGP_01237 246200.SPO2272 1.7e-83 315.8 Ruegeria hisA GO:0000105,GO:0003674,GO:0003824,GO:0003949,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.4.19,3.6.1.31,5.3.1.16 ko:K01814,ko:K11755 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035,R04037,R04640 RC00002,RC00945,RC01055 ko00000,ko00001,ko00002,ko01000 Bacteria 1R41G@1224,2U0NV@28211,4NAGA@97050,COG0106@1,COG0106@2 NA|NA|NA E 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity HIMHAPGP_01239 1522072.IL54_4559 2.7e-128 465.7 Sphingomonadales Bacteria 1MY01@1224,2K0XM@204457,2U2RG@28211,COG1680@1,COG1680@2 NA|NA|NA V Beta-lactamase HIMHAPGP_01240 1030157.AFMP01000062_gene3519 1.7e-85 322.4 Sphingomonadales rpsB GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02967 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1MU33@1224,2K0DP@204457,2TRXE@28211,COG0052@1,COG0052@2 NA|NA|NA J Belongs to the universal ribosomal protein uS2 family HIMHAPGP_01241 1123269.NX02_14370 1.6e-99 369.4 Sphingomonadales tsf GO:0001871,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005085,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0019538,GO:0019899,GO:0030246,GO:0030247,GO:0034641,GO:0034645,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051020,GO:0065007,GO:0065009,GO:0071704,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065 ko:K02357 ko00000,ko03012,ko03029 Bacteria 1MUS2@1224,2JZY1@204457,2TQM0@28211,COG0264@1,COG0264@2 NA|NA|NA J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome HIMHAPGP_01242 1502850.FG91_03476 2.6e-100 371.7 Sphingomonadales pyrH GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0033862,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 R00158 RC00002 ko00000,ko00001,ko01000 Bacteria 1MV3N@1224,2K1B1@204457,2TQYN@28211,COG0528@1,COG0528@2 NA|NA|NA F Catalyzes the reversible phosphorylation of UMP to UDP HIMHAPGP_01243 1123269.NX02_14360 1.2e-71 276.2 Sphingomonadales frr GO:0002181,GO:0002184,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0030312,GO:0032984,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02838 ko00000,ko03012 Bacteria 1N66T@1224,2K00Z@204457,2U5B2@28211,COG0233@1,COG0233@2 NA|NA|NA J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another HIMHAPGP_01244 1234595.C725_0496 1e-78 300.1 unclassified Alphaproteobacteria uppS GO:0000270,GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006066,GO:0006629,GO:0006720,GO:0006807,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008834,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030203,GO:0034645,GO:0042546,GO:0043164,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 iECBD_1354.ECBD_3445,iECOK1_1307.ECOK1_0175,iECSE_1348.ECSE_0173,iECW_1372.ECW_m0170,iEKO11_1354.EKO11_3744,iEcDH1_1363.EcDH1_3429,iEcE24377_1341.EcE24377A_0178,iEcHS_1320.EcHS_A0176,iNRG857_1313.NRG857_00890,iSFV_1184.SFV_0157,iUMN146_1321.UM146_23675,iUMNK88_1353.UMNK88_178,iWFL_1372.ECW_m0170,iY75_1357.Y75_RS00880 Bacteria 1MVP1@1224,2TTVJ@28211,4BPYJ@82117,COG0020@1,COG0020@2 NA|NA|NA I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids HIMHAPGP_01245 1030157.AFMP01000062_gene3514 2.6e-51 209.1 Sphingomonadales cdsA 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 1MWSV@1224,2K1ET@204457,2U9ED@28211,COG0575@1,COG0575@2 NA|NA|NA I Belongs to the CDS family HIMHAPGP_01246 1123269.NX02_14345 1.2e-123 449.9 Sphingomonadales dxr GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0050897,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 iAPECO1_1312.APECO1_1814,iECOK1_1307.ECOK1_0174,iECS88_1305.ECS88_0183,iHN637.CLJU_RS06420,iNJ661.Rv2870c,iUMN146_1321.UM146_23670,iUTI89_1310.UTI89_C0188 Bacteria 1MU4G@1224,2K0YA@204457,2TSD1@28211,COG0743@1,COG0743@2 NA|NA|NA I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) HIMHAPGP_01247 1248916.ANFY01000009_gene142 3.2e-113 415.2 Sphingomonadales rseP GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016021,GO:0016787,GO:0019219,GO:0019222,GO:0019538,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0043170,GO:0043856,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0045152,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:0140110,GO:1901564,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 3.4.21.107 ko:K04771,ko:K11749 ko01503,ko02020,ko02024,ko04112,map01503,map02020,map02024,map04112 M00728 ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 Bacteria 1MU91@1224,2K0AZ@204457,2TQXJ@28211,COG0750@1,COG0750@2 NA|NA|NA M zinc metalloprotease HIMHAPGP_01248 392499.Swit_0468 1.2e-296 1025.8 Sphingomonadales bamA ko:K07277 ko00000,ko02000,ko03029 1.B.33 Bacteria 1MU0D@1224,2K0GI@204457,2TR7W@28211,COG4775@1,COG4775@2 NA|NA|NA M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HIMHAPGP_01249 1123240.ATVO01000003_gene385 2e-29 136.0 Alphaproteobacteria ompH ko:K06142 ko00000 Bacteria 1NNT2@1224,2UM5J@28211,COG2825@1,COG2825@2 NA|NA|NA M Outer membrane protein (OmpH-like) HIMHAPGP_01250 629773.AORY01000001_gene1988 5e-59 233.8 Sphingomonadales fabZ GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0019171 3.5.1.108,4.2.1.59 ko:K02372,ko:K16363 ko00061,ko00540,ko00780,ko01100,ko01212,map00061,map00540,map00780,map01100,map01212 M00060,M00083,M00572 R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965,R07764,R10117,R10121 RC00166,RC00300,RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004,ko01005 Bacteria 1RH2T@1224,2K4JA@204457,2U7G4@28211,COG0764@1,COG0764@2 NA|NA|NA I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs HIMHAPGP_01251 383381.EH30_15625 1.1e-36 159.8 Sphingomonadales mobA 2.7.7.77 ko:K03752 ko00790,ko01100,map00790,map01100 R11581 ko00000,ko00001,ko01000 Bacteria 1N1GK@1224,2K5W9@204457,2UDGM@28211,COG0746@1,COG0746@2 NA|NA|NA H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor HIMHAPGP_01252 1123240.ATVO01000003_gene379 2.3e-183 648.3 Sphingomonadales ivd 1.3.8.4 ko:K00253 ko00280,ko01100,map00280,map01100 M00036 R04095 RC00246 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUDR@1224,2K1PX@204457,2TREJ@28211,COG1960@1,COG1960@2 NA|NA|NA I Catalyzes the formation of 3-methylbut-2-enoyl CoA from 3-methylbutanoyl CoA HIMHAPGP_01253 1248916.ANFY01000009_gene131 3e-188 665.2 Sphingomonadales mccA 6.4.1.1,6.4.1.3,6.4.1.4 ko:K01960,ko:K01965,ko:K01968 ko00020,ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01120,ko01130,ko01200,ko01230,map00020,map00280,map00620,map00630,map00640,map00720,map01100,map01120,map01130,map01200,map01230 M00036,M00173,M00373,M00620,M00741 R00344,R01859,R04138 RC00040,RC00097,RC00367,RC00609,RC00942 ko00000,ko00001,ko00002,ko01000 Bacteria 1P6RE@1224,2K27B@204457,2TRC2@28211,COG4770@1,COG4770@2 NA|NA|NA I acetyl propionyl-CoA carboxylase, alpha subunit HIMHAPGP_01254 1248916.ANFY01000009_gene129 3.6e-76 291.6 Sphingomonadales liuC 4.2.1.18 ko:K13766 ko00280,ko01100,map00280,map01100 M00036 R02085 RC02416 ko00000,ko00001,ko00002,ko01000 Bacteria 1MVEC@1224,2KAUF@204457,2TRPS@28211,COG1024@1,COG1024@2 NA|NA|NA I Enoyl-CoA hydratase/isomerase HIMHAPGP_01255 1123240.ATVO01000003_gene372 9.3e-236 822.8 Sphingomonadales mccB 2.1.3.15,6.4.1.3,6.4.1.4 ko:K01969,ko:K15052 ko00280,ko00720,ko01100,ko01200,map00280,map00720,map01100,map01200 M00036,M00376 R01859,R04138 RC00097,RC00367,RC00609,RC00942 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_3290 Bacteria 1MVAX@1224,2K0B0@204457,2TRA0@28211,COG4799@1,COG4799@2 NA|NA|NA I acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) HIMHAPGP_01256 1144305.PMI02_00510 9.2e-28 129.0 Sphingomonadales rpmE GO:0008150,GO:0040007 ko:K02909 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1MZ69@1224,2K643@204457,2UBSC@28211,COG0254@1,COG0254@2 NA|NA|NA J 50S ribosomal protein L31 HIMHAPGP_01257 1120792.JAFV01000001_gene1221 2.6e-107 396.0 Methylocystaceae nnrD GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0052855,GO:0052856,GO:0052857 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 ko00000,ko01000 Bacteria 1MU1Q@1224,2TT58@28211,36XXM@31993,COG0062@1,COG0062@2,COG0063@1,COG0063@2 NA|NA|NA G YjeF-related protein N-terminus HIMHAPGP_01258 314231.FP2506_01110 4.3e-18 98.2 Alphaproteobacteria Bacteria 1R49V@1224,2TTDC@28211,COG2199@1,COG2199@2 NA|NA|NA T Diguanylate cyclase HIMHAPGP_01259 414684.RC1_3134 2.1e-38 165.6 Rhodospirillales ami 3.2.1.96,3.4.17.14,3.5.1.28,6.1.1.12 ko:K01227,ko:K01447,ko:K01448,ko:K01876,ko:K06385,ko:K07260,ko:K11060,ko:K11062 ko00511,ko00550,ko00970,ko01100,ko01502,ko01503,ko02020,map00511,map00550,map00970,map01100,map01502,map01503,map02020 M00359,M00360,M00651,M00727 R04112,R05577 RC00055,RC00064,RC00141,RC00523 ko00000,ko00001,ko00002,ko01000,ko01002,ko01007,ko01011,ko01504,ko02042,ko03016,ko03029,ko03036 Bacteria 1RHM2@1224,2JSPB@204441,2UA1R@28211,COG3807@1,COG3807@2 NA|NA|NA S protein conserved in bacteria HIMHAPGP_01260 1123240.ATVO01000004_gene1180 1e-123 449.9 Sphingomonadales gyaR GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.1.1.26 ko:K00015 ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120 R00717,R01388 RC00031,RC00042 ko00000,ko00001,ko01000 Bacteria 1MU2D@1224,2K0RX@204457,2TSM8@28211,COG1052@1,COG1052@2 NA|NA|NA CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family HIMHAPGP_01261 1248916.ANFY01000003_gene909 2.7e-170 605.9 Sphingomonadales GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K07001 ko00000 Bacteria 1MWH2@1224,2K0ET@204457,2TU16@28211,COG1752@1,COG1752@2 NA|NA|NA S Protein of unknown function (DUF3376) HIMHAPGP_01262 1470591.BW41_02290 6.5e-121 440.7 Sphingomonadales queG GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 ko:K18979 ko00000,ko01000,ko03016 Bacteria 1MV1H@1224,2K0HW@204457,2TR5E@28211,COG1600@1,COG1600@2 NA|NA|NA C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) HIMHAPGP_01263 1248916.ANFY01000007_gene2509 4.5e-75 287.7 Sphingomonadales gst 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 Bacteria 1MXM4@1224,2K1DG@204457,2TTXD@28211,COG0625@1,COG0625@2 NA|NA|NA O Glutathione S-transferase HIMHAPGP_01266 1234595.C725_0702 1.1e-16 91.7 unclassified Alphaproteobacteria ctaE GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 iJN678.ctaE Bacteria 1MUCK@1224,2TQWA@28211,4BP5G@82117,COG1845@1,COG1845@2 NA|NA|NA C Heme copper-type cytochrome quinol oxidase, subunit 3 HIMHAPGP_01267 685778.AORL01000022_gene1379 1.1e-25 123.6 Sphingomonadales surf-1 ko:K14998 ko00000,ko03029 3.D.4.8 Bacteria 1RIJQ@1224,2K34C@204457,2UA1G@28211,COG3346@1,COG3346@2 NA|NA|NA S SURF1-like protein HIMHAPGP_01268 1331060.RLDS_14660 1.2e-167 596.3 Sphingomonadales thrC GO:0003674,GO:0003824,GO:0004795,GO:0006082,GO:0006520,GO:0006566,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016053,GO:0016311,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUWQ@1224,2K0KX@204457,2TT0D@28211,COG0498@1,COG0498@2 NA|NA|NA E Threonine synthase HIMHAPGP_01269 1030157.AFMP01000040_gene1397 1.5e-103 383.3 Sphingomonadales pepR GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 1MVST@1224,2K1F2@204457,2TR39@28211,COG0612@1,COG0612@2 NA|NA|NA S PFAM peptidase M16 domain protein HIMHAPGP_01270 13689.BV96_04174 1e-103 383.3 Sphingomonadales rlmI 2.1.1.191 ko:K06969 ko00000,ko01000,ko03009 Bacteria 1QSD4@1224,2K037@204457,2TUFT@28211,COG1092@1,COG1092@2 NA|NA|NA J Belongs to the methyltransferase superfamily HIMHAPGP_01271 1003200.AXXA_24970 1.7e-48 199.9 Alcaligenaceae Bacteria 1R0I9@1224,2VRVM@28216,3T1H7@506,COG2242@1,COG2242@2 NA|NA|NA H COG0500 SAM-dependent methyltransferases HIMHAPGP_01272 314265.R2601_01788 6.7e-14 83.6 Alphaproteobacteria aruH 2.6.1.84,3.6.3.21 ko:K02028,ko:K12252 ko00330,ko01100,map00330,map01100 M00236 R08197 RC00006,RC00008 ko00000,ko00001,ko00002,ko01000,ko01007,ko02000 3.A.1.3 Bacteria 1MW0Z@1224,2TTU3@28211,COG0436@1,COG0436@2 NA|NA|NA E COG0436 Aspartate tyrosine aromatic aminotransferase HIMHAPGP_01273 391600.ABRU01000045_gene1595 1.9e-82 312.0 Caulobacterales ahpC GO:0003674,GO:0003824,GO:0004601,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009321,GO:0009605,GO:0009636,GO:0009970,GO:0009987,GO:0009991,GO:0010033,GO:0016209,GO:0016491,GO:0016667,GO:0016671,GO:0016684,GO:0019725,GO:0030003,GO:0031667,GO:0031668,GO:0031669,GO:0032843,GO:0032991,GO:0033194,GO:0033195,GO:0033212,GO:0033214,GO:0033554,GO:0042221,GO:0042592,GO:0042594,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071496,GO:0097237,GO:0098754,GO:0098771,GO:0098869,GO:1901700,GO:1902494,GO:1990204,GO:1990748 1.11.1.15 ko:K03386 ko04214,map04214 ko00000,ko00001,ko01000,ko04147 Bacteria 1MWPY@1224,2KF9D@204458,2TV43@28211,COG0450@1,COG0450@2 NA|NA|NA O With AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols HIMHAPGP_01274 666685.R2APBS1_1543 1.3e-221 775.8 Xanthomonadales ahpF GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008785,GO:0009321,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071949,GO:0097159,GO:1901265,GO:1901363,GO:1902494,GO:1990204 ko:K03387 ko00000,ko01000 Bacteria 1MUKD@1224,1RNC7@1236,1X4HZ@135614,COG3634@1,COG3634@2 NA|NA|NA O Alkyl hydroperoxide reductase HIMHAPGP_01276 1443111.JASG01000004_gene3053 9.4e-36 156.4 Sulfitobacter arsC 1.20.4.1 ko:K00537 ko00000,ko01000 Bacteria 1MZ4Z@1224,2U70U@28211,3ZXDW@60136,COG1393@1,COG1393@2 NA|NA|NA P ArsC family HIMHAPGP_01277 1123240.ATVO01000006_gene1368 2.3e-119 435.3 Sphingomonadales panB 2.1.2.11,6.3.2.1 ko:K00606,ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R01226,R02473 RC00022,RC00096,RC00141,RC00200 ko00000,ko00001,ko00002,ko01000 Bacteria 1MU3B@1224,2K1CJ@204457,2TQT1@28211,COG0413@1,COG0413@2 NA|NA|NA H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate HIMHAPGP_01278 1030157.AFMP01000040_gene1584 6e-42 177.9 Sphingomonadales Bacteria 1P2GI@1224,2K40C@204457,2UCFZ@28211,COG4649@1,COG4649@2 NA|NA|NA S Tetratricopeptide repeat-like domain HIMHAPGP_01279 1207055.C100_23445 2.4e-107 396.0 Sphingomonadales bamB GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0008152,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0016491,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0042802,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0055114,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 ko:K17713 ko00000,ko02000 1.B.33.1 Bacteria 1MXIJ@1224,2K0GW@204457,2TUAD@28211,COG1520@1,COG1520@2 NA|NA|NA S Pyrrolo-quinoline quinone HIMHAPGP_01280 1234595.C725_2283 1.1e-168 599.7 unclassified Alphaproteobacteria der GO:0000027,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022607,GO:0022613,GO:0022618,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032794,GO:0034622,GO:0035639,GO:0036094,GO:0042254,GO:0042255,GO:0042273,GO:0043021,GO:0043022,GO:0043023,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363 ko:K03977 ko00000,ko03009 Bacteria 1MU9S@1224,2TT38@28211,4BPC6@82117,COG1160@1,COG1160@2 NA|NA|NA S GTPase that plays an essential role in the late steps of ribosome biogenesis HIMHAPGP_01281 685778.AORL01000021_gene791 2.6e-139 502.3 Sphingomonadales fadD Bacteria 1MU6G@1224,2K0DK@204457,2TRP2@28211,COG0318@1,COG0318@2 NA|NA|NA IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II HIMHAPGP_01282 1174684.EBMC1_14063 1.8e-138 499.2 Sphingomonadales btrK 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUA6@1224,2K0RW@204457,2TUK2@28211,COG0019@1,COG0019@2 NA|NA|NA E Belongs to the Orn Lys Arg decarboxylase class-II family HIMHAPGP_01283 1219045.BV98_000126 4.5e-87 327.8 Sphingomonadales truA GO:0000049,GO:0001522,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0030312,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363 5.4.99.12 ko:K06173 ko00000,ko01000,ko03016 Bacteria 1MUYI@1224,2K0ZD@204457,2TR57@28211,COG0101@1,COG0101@2 NA|NA|NA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs HIMHAPGP_01284 1294273.roselon_01452 2.5e-53 215.3 Alphaproteobacteria fmt GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0040007,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 R03940 RC00026,RC00165 ko00000,ko00001,ko01000 Bacteria 1MU4Q@1224,2TSWX@28211,COG0223@1,COG0223@2 NA|NA|NA J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus HIMHAPGP_01285 1131813.AQVT01000001_gene876 4.8e-13 79.7 Methylobacteriaceae fumC GO:0003674,GO:0003824,GO:0004333,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 Bacteria 1JTD2@119045,1MUQI@1224,2TQM7@28211,COG0114@1,COG0114@2 NA|NA|NA C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate HIMHAPGP_01286 1248916.ANFY01000003_gene681 6.2e-74 283.9 Sphingomonadales gmk GO:0003674,GO:0003824,GO:0004385,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8,4.1.1.23 ko:K00942,ko:K01591 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00050,M00051 R00332,R00965,R02090 RC00002,RC00409 ko00000,ko00001,ko00002,ko01000 iAPECO1_1312.APECO1_2813,iIT341.HP0321,iPC815.YPO0040,iSBO_1134.SBO_3729,iSFV_1184.SFV_3881,iSFxv_1172.SFxv_4016,iUTI89_1310.UTI89_C4193 Bacteria 1MW92@1224,2K16A@204457,2TSCQ@28211,COG0194@1,COG0194@2 NA|NA|NA F Essential for recycling GMP and indirectly, cGMP HIMHAPGP_01287 1123269.NX02_27860 3.3e-27 128.3 Sphingomonadales Bacteria 1N363@1224,2DC1J@1,2KEWQ@204457,2U01A@28211,333E1@2 NA|NA|NA HIMHAPGP_01288 450851.PHZ_c0388 6.2e-173 613.6 Caulobacterales 1.3.8.8 ko:K00255 ko00071,ko01100,ko01212,ko03320,map00071,map01100,map01212,map03320 M00087 R01279,R03777,R03857,R03990,R04751,R04754 RC00052 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUDR@1224,2KF2X@204458,2TR15@28211,COG1960@1,COG1960@2 NA|NA|NA C PFAM acyl-CoA dehydrogenase domain protein HIMHAPGP_01289 1449076.JOOE01000004_gene548 4.1e-27 127.1 Sphingomonadales atpC GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 ko:K02113,ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 Bacteria 1RHE4@1224,2K5WN@204457,2UBXX@28211,COG0355@1,COG0355@2 NA|NA|NA C Produces ATP from ADP in the presence of a proton gradient across the membrane HIMHAPGP_01290 1449076.JOOE01000004_gene549 3.1e-76 291.2 Sphingomonadales atpD GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 e_coli_core.b3732,iAF1260.b3732,iAPECO1_1312.APECO1_2729,iB21_1397.B21_03560,iBWG_1329.BWG_3423,iE2348C_1286.E2348C_4042,iEC042_1314.EC042_4119,iEC55989_1330.EC55989_4207,iECABU_c1320.ECABU_c42160,iECBD_1354.ECBD_4300,iECB_1328.ECB_03616,iECDH10B_1368.ECDH10B_3919,iECDH1ME8569_1439.ECDH1ME8569_3620,iECD_1391.ECD_03616,iECED1_1282.ECED1_4422,iECH74115_1262.ECH74115_5168,iECIAI1_1343.ECIAI1_3916,iECIAI39_1322.ECIAI39_4336,iECNA114_1301.ECNA114_3881,iECO103_1326.ECO103_4426,iECO111_1330.ECO111_4566,iECO26_1355.ECO26_4846,iECOK1_1307.ECOK1_4181,iECP_1309.ECP_3931,iECS88_1305.ECS88_4154,iECSE_1348.ECSE_4022,iECSF_1327.ECSF_3580,iECSP_1301.ECSP_4782,iECUMN_1333.ECUMN_4262,iECW_1372.ECW_m4035,iECs_1301.ECs4674,iEKO11_1354.EKO11_4613,iETEC_1333.ETEC_4023,iEcDH1_1363.EcDH1_4235,iEcE24377_1341.EcE24377A_4247,iEcSMS35_1347.EcSMS35_4100,iEcolC_1368.EcolC_4262,iG2583_1286.G2583_4528,iJO1366.b3732,iJR904.b3732,iLF82_1304.LF82_0194,iNRG857_1313.NRG857_18585,iPC815.YPO4121,iSFV_1184.SFV_3758,iSF_1195.SF3812,iSFxv_1172.SFxv_4154,iSSON_1240.SSON_3887,iS_1188.S3956,iSbBS512_1146.SbBS512_E4189,iUMN146_1321.UM146_18850,iUMNK88_1353.UMNK88_4544,iUTI89_1310.UTI89_C4285,iWFL_1372.ECW_m4035,iY75_1357.Y75_RS18410,iZ_1308.Z5230,ic_1306.c4658 Bacteria 1MUFU@1224,2K03H@204457,2TRGP@28211,COG0055@1,COG0055@2 NA|NA|NA C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits HIMHAPGP_01292 1248916.ANFY01000003_gene586 9.8e-31 139.8 Sphingomonadales rrf2 Bacteria 1N0E2@1224,2KD5Z@204457,2U9Z9@28211,COG1959@1,COG1959@2 NA|NA|NA K Transcriptional regulator HIMHAPGP_01293 1248916.ANFY01000003_gene473 4.8e-53 214.2 Sphingomonadales ko:K03704 ko00000,ko03000 Bacteria 1N6Q5@1224,2JZZ2@204457,2UF6W@28211,COG1278@1,COG1278@2 NA|NA|NA K Cold shock HIMHAPGP_01294 627192.SLG_07080 2e-12 78.2 Sphingomonadales putA GO:0000166,GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0003824,GO:0003842,GO:0004657,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006355,GO:0006520,GO:0006536,GO:0006560,GO:0006562,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009889,GO:0009890,GO:0009892,GO:0009898,GO:0009987,GO:0010133,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0016054,GO:0016491,GO:0016645,GO:0016646,GO:0019219,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043565,GO:0043648,GO:0044212,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044425,GO:0044459,GO:0044464,GO:0045892,GO:0045934,GO:0046395,GO:0046483,GO:0046700,GO:0048037,GO:0048519,GO:0048523,GO:0050660,GO:0050662,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0055114,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:0098552,GO:0098562,GO:0140110,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 1.2.1.88,1.3.8.7,1.5.5.2 ko:K00249,ko:K00294,ko:K13821 ko00071,ko00250,ko00280,ko00330,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00250,map00280,map00330,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00245,R00707,R00708,R00924,R01175,R01253,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04444,R04445,R04751,R04754,R05051 RC00052,RC00068,RC00076,RC00080,RC00083,RC00095,RC00148,RC00216,RC00242,RC00246,RC00255 ko00000,ko00001,ko00002,ko01000,ko03000 iPC815.YPO1851,iSbBS512_1146.SbBS512_E2304 Bacteria 1MV93@1224,2K1B6@204457,2TQPT@28211,COG0506@1,COG0506@2,COG4230@1,COG4230@2 NA|NA|NA CE Oxidizes proline to glutamate for use as a carbon and nitrogen source HIMHAPGP_01295 1205680.CAKO01000042_gene5366 3.7e-112 411.4 Rhodospirillales Bacteria 1MZ25@1224,2JZAC@204441,2TRJH@28211,COG1262@1,COG1262@2 NA|NA|NA S Sulfatase-modifying factor enzyme 1 HIMHAPGP_01296 1112216.JH594425_gene1162 1.6e-245 855.5 Sphingomonadales Bacteria 1MUHZ@1224,2K0CU@204457,2TRZF@28211,COG3975@1,COG3975@2 NA|NA|NA S protease with the C-terminal PDZ HIMHAPGP_01297 1007104.SUS17_1119 7.8e-178 630.2 Sphingomonadales sdaA 4.3.1.17 ko:K01752 ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 R00220,R00590 RC00331,RC02600 ko00000,ko00001,ko01000 Bacteria 1MUZN@1224,2K0NS@204457,2TR3D@28211,COG1760@1,COG1760@2 NA|NA|NA E PFAM Serine dehydratase alpha chain HIMHAPGP_01298 1030157.AFMP01000031_gene3026 3.7e-30 138.3 Sphingomonadales 2.7.7.76 ko:K07141 ko00790,map00790 R11582 ko00000,ko00001,ko01000 Bacteria 1MW0X@1224,2K40X@204457,2TR5D@28211,COG2068@1,COG2068@2 NA|NA|NA S MobA-like NTP transferase domain HIMHAPGP_01299 745310.G432_16105 2.6e-66 259.2 Sphingomonadales 2.7.7.76 ko:K07141 ko00790,map00790 R11582 ko00000,ko00001,ko01000 Bacteria 1QUKM@1224,2K4B4@204457,2TWCK@28211,COG0303@1,COG0303@2 NA|NA|NA H COG0303 Molybdopterin biosynthesis enzyme HIMHAPGP_01300 745310.G432_16100 1.1e-98 366.7 Sphingomonadales pucA ko:K07402 ko00000 Bacteria 1MXKU@1224,2K17D@204457,2TUF3@28211,COG1975@1,COG1975@2 NA|NA|NA O Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family HIMHAPGP_01301 1123240.ATVO01000005_gene1750 6.9e-43 180.6 Alphaproteobacteria ko:K09386 ko00000 Bacteria 1RHUC@1224,2U9HD@28211,COG3427@1,COG3427@2 NA|NA|NA S carbon monoxide dehydrogenase HIMHAPGP_01302 1248916.ANFY01000011_gene1112 2.4e-38 165.6 Sphingomonadales cspB ko:K03704 ko00000,ko03000 Bacteria 1RAUE@1224,2K4T8@204457,2U0S7@28211,COG1278@1,COG1278@2 NA|NA|NA K Cold shock protein domain HIMHAPGP_01303 13689.BV96_02513 4.4e-32 144.1 Sphingomonadales ko:K09005 ko00000 Bacteria 1MZBJ@1224,2K5JY@204457,2UBSI@28211,COG1430@1,COG1430@2 NA|NA|NA S Uncharacterized ACR, COG1430 HIMHAPGP_01304 1123240.ATVO01000006_gene1435 4.3e-30 137.5 Sphingomonadales MA20_29090 1.6.99.3 ko:K00356 ko00190,map00190 ko00000,ko00001,ko01000 Bacteria 1RHS3@1224,2K5FH@204457,2U95G@28211,COG3761@1,COG3761@2 NA|NA|NA C NADH ubiquinone oxidoreductase 17.2 kD subunit HIMHAPGP_01305 194867.ALBQ01000059_gene3287 5.5e-104 384.0 Sphingomonadales ychF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 ko:K06942 ko00000,ko03009 Bacteria 1MVM4@1224,2K213@204457,2TRAD@28211,COG0012@1,COG0012@2 NA|NA|NA J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner HIMHAPGP_01306 765911.Thivi_1386 2.8e-83 315.5 Chromatiales Bacteria 1MXVG@1224,1RSB7@1236,1WZ16@135613,COG3965@1,COG3965@2 NA|NA|NA P cation diffusion facilitator family transporter HIMHAPGP_01307 392499.Swit_1421 7.5e-42 177.2 Sphingomonadales ccmA GO:0003674,GO:0003824,GO:0005215,GO:0006810,GO:0008150,GO:0015232,GO:0015399,GO:0015405,GO:0015439,GO:0015886,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0042623,GO:0042626,GO:0043492,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:1901678 3.6.3.41 ko:K02193 ko02010,map02010 M00259 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.107 Bacteria 1MZPC@1224,2K5BJ@204457,2TVBT@28211,COG4133@1,COG4133@2 NA|NA|NA O once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system HIMHAPGP_01309 1234595.C725_0023 2.6e-54 218.4 unclassified Alphaproteobacteria yrdA Bacteria 1RD76@1224,2U5GR@28211,4BQED@82117,COG0663@1,COG0663@2 NA|NA|NA S Bacterial transferase hexapeptide (six repeats) HIMHAPGP_01310 58123.JOFJ01000007_gene750 2.3e-42 178.7 Streptosporangiales 1.1.1.25,2.3.1.128,4.2.1.10 ko:K03790,ko:K13832 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413,R03084 RC00206,RC00848 ko00000,ko00001,ko00002,ko01000,ko03009 Bacteria 2GP87@201174,4EJAX@85012,COG1670@1,COG1670@2 NA|NA|NA J Acetyltransferase (GNAT) domain HIMHAPGP_01311 502025.Hoch_4398 6.3e-30 137.5 Myxococcales Bacteria 1N18Y@1224,2X0G7@28221,2Z0UB@29,435YY@68525,COG1670@1,COG1670@2 NA|NA|NA J Acetyltransferase (GNAT) domain HIMHAPGP_01312 1123240.ATVO01000005_gene1832 1.2e-143 516.2 Sphingomonadales argC GO:0003674,GO:0003824,GO:0003942,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 iLJ478.TM1782,iSSON_1240.SSON_4131,iYO844.BSU11190 Bacteria 1MVJ6@1224,2K2G3@204457,2TRMT@28211,COG0002@1,COG0002@2 NA|NA|NA E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde HIMHAPGP_01313 1174684.EBMC1_07570 4.9e-185 654.8 Sphingomonadales MA20_01900 Bacteria 1N1PJ@1224,2K0FC@204457,2TUJQ@28211,COG0421@1,COG0421@2 NA|NA|NA E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine HIMHAPGP_01314 391600.ABRU01000051_gene638 3.1e-34 151.8 Caulobacterales ogt GO:0003674,GO:0003824,GO:0003908,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 2.1.1.63 ko:K00567 ko00000,ko01000,ko03400 Bacteria 1N2YQ@1224,2KGW8@204458,2TRRN@28211,COG0350@1,COG0350@2 NA|NA|NA L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated HIMHAPGP_01315 1123269.NX02_11060 6.2e-193 680.2 Sphingomonadales rimO 2.8.4.4 ko:K14441 R10652 RC00003,RC03217 ko00000,ko01000,ko03009 Bacteria 1MU7N@1224,2K1QA@204457,2TQUS@28211,COG0621@1,COG0621@2 NA|NA|NA J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 HIMHAPGP_01316 1123267.JONN01000002_gene197 8.3e-79 300.1 Sphingomonadales folE GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 Bacteria 1MY3N@1224,2K0QV@204457,2TSZI@28211,COG0302@1,COG0302@2 NA|NA|NA H GTP cyclohydrolase HIMHAPGP_01317 1331060.RLDS_06050 9.9e-09 65.1 Sphingomonadales ko:K08191 ko00000,ko02000 2.A.1.14.2 Bacteria 1MV04@1224,2K1NR@204457,2U253@28211,COG2271@1,COG2271@2 NA|NA|NA G Major Facilitator Superfamily HIMHAPGP_01318 67352.JODS01000005_gene6128 5.5e-38 164.5 Actinobacteria Bacteria 2HRC6@201174,COG1280@1,COG1280@2 NA|NA|NA E Sap, sulfolipid-1-addressing protein HIMHAPGP_01319 1123269.NX02_28500 2.1e-140 506.1 Sphingomonadales pabB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046820,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.6.1.85,4.1.3.27,4.1.3.38 ko:K01665,ko:K02619,ko:K03342,ko:K13503,ko:K13950 ko00400,ko00790,ko01100,ko01110,ko01130,ko01230,map00400,map00790,map01100,map01110,map01130,map01230 M00023 R00985,R00986,R01716,R05553 RC00010,RC01418,RC01843,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 1MVBJ@1224,2K1FB@204457,2TUBY@28211,COG0115@1,COG0115@2,COG0147@1,COG0147@2 NA|NA|NA EH component I HIMHAPGP_01320 1123240.ATVO01000003_gene539 7.4e-177 626.7 Sphingomonadales aatA 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 Bacteria 1MW0Z@1224,2K0HJ@204457,2TRPK@28211,COG0436@1,COG0436@2 NA|NA|NA E Catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate HIMHAPGP_01321 1112212.JH584235_gene1864 2.4e-41 175.6 Sphingomonadales Bacteria 1P4TB@1224,2K3BN@204457,2UHTZ@28211,COG0560@1,COG0560@2 NA|NA|NA E haloacid dehalogenase-like hydrolase HIMHAPGP_01322 322710.Avin_08950 6.1e-24 117.5 Gammaproteobacteria nucH GO:0003674,GO:0003824,GO:0004518,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:1901360,GO:1901361,GO:1901575 2.1.1.113,3.1.31.1 ko:K00590,ko:K01174,ko:K02027,ko:K07038,ko:K16561 M00207 ko00000,ko00002,ko01000,ko02000,ko02048 3.A.1.1 Bacteria 1N145@1224,1S9I3@1236,COG1525@1,COG1525@2 NA|NA|NA L nuclease HIMHAPGP_01323 1030157.AFMP01000016_gene2487 5.2e-103 381.3 Sphingomonadales ko:K02066 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 1MVPN@1224,2K10W@204457,2TSGS@28211,COG0767@1,COG0767@2 NA|NA|NA Q ABC-type transport system involved in resistance to organic solvents, permease component HIMHAPGP_01324 392499.Swit_2743 8.9e-94 350.1 Sphingomonadales iamA ko:K02065,ko:K02067 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 1MUSD@1224,2K11G@204457,2TR2I@28211,COG1127@1,COG1127@2 NA|NA|NA Q ABC-type transport system involved in resistance to organic solvents, ATPase component HIMHAPGP_01325 392499.Swit_2744 7.7e-76 290.8 Sphingomonadales iamC ko:K02067 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 1MU4B@1224,2K12E@204457,2U1JN@28211,COG1463@1,COG1463@2 NA|NA|NA Q ABC-type transport system involved in resistance to organic solvents, periplasmic component HIMHAPGP_01326 1248916.ANFY01000003_gene968 2.9e-28 132.1 Sphingomonadales linN ko:K09857,ko:K18480 M00669 ko00000,ko00002,ko02000 3.A.1.27.1 Bacteria 1RKTW@1224,2KCCN@204457,2UIN8@28211,COG3218@1,COG3218@2 NA|NA|NA S ABC-type transport auxiliary lipoprotein component HIMHAPGP_01328 768671.ThimaDRAFT_4169 1.7e-228 798.9 Chromatiales Bacteria 1MWP2@1224,1RNB7@1236,1WXFC@135613,COG1574@1,COG1574@2 NA|NA|NA S Amidohydrolase family HIMHAPGP_01330 1123229.AUBC01000004_gene3277 4.8e-190 670.6 Bradyrhizobiaceae rkpK GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 Bacteria 1MW5U@1224,2TREV@28211,3JTIE@41294,COG1004@1,COG1004@2 NA|NA|NA M Belongs to the UDP-glucose GDP-mannose dehydrogenase family HIMHAPGP_01331 279238.Saro_2788 1.2e-12 80.9 Sphingomonadales Bacteria 1RF3T@1224,291EX@1,2K4S8@204457,2U83Z@28211,2ZP1S@2 NA|NA|NA HIMHAPGP_01332 1219049.SP5_043_00790 5.9e-25 121.3 Sphingomonadales hemD GO:0003674,GO:0003824,GO:0004852,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107,2.5.1.61,4.2.1.75 ko:K01719,ko:K01749,ko:K02496,ko:K13542,ko:K13543 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084,R03165,R03194 RC00003,RC00871,RC01861,RC02317 ko00000,ko00001,ko00002,ko01000 iJN746.PP_0187,iSBO_1134.SBO_3815 Bacteria 1NMTP@1224,2K52Q@204457,2UMED@28211,COG1587@1,COG1587@2 NA|NA|NA H Uroporphyrinogen-III synthase HIMHAPGP_01333 452662.SJA_C1-03160 1.4e-80 306.6 Sphingomonadales hemC 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 Bacteria 1MU56@1224,2K19Y@204457,2TS3D@28211,COG0181@1,COG0181@2 NA|NA|NA H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps HIMHAPGP_01335 1134912.AJTV01000013_gene579 1.1e-103 383.3 Methylocystaceae ydbC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 1.1.1.65 ko:K05275 ko00750,ko01100,ko01120,map00750,map01100,map01120 R01708 RC00116 ko00000,ko00001,ko01000 Bacteria 1MWGZ@1224,2TTY4@28211,36XMV@31993,COG0667@1,COG0667@2 NA|NA|NA C Aldo/keto reductase family HIMHAPGP_01337 745310.G432_13315 3.8e-104 384.4 Sphingomonadales uvrA ko:K03701 ko03420,map03420 ko00000,ko00001,ko03400 Bacteria 1MW0W@1224,2K0VM@204457,2TQK9@28211,COG0178@1,COG0178@2 NA|NA|NA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate HIMHAPGP_01338 883080.HMPREF9697_00664 4.9e-17 93.6 Bradyrhizobiaceae ko:K06975 ko00000 Bacteria 1N8AQ@1224,2UFVS@28211,3K0T0@41294,COG2388@1,COG2388@2 NA|NA|NA S GCN5-related N-acetyl-transferase HIMHAPGP_01340 1122970.AUHC01000009_gene271 6.1e-17 93.6 Sphingomonadales dskA ko:K06204 ko02026,map02026 ko00000,ko00001,ko03000,ko03009,ko03021 Bacteria 1N8K6@1224,2K7PQ@204457,2UCF1@28211,COG1734@1,COG1734@2 NA|NA|NA T Prokaryotic dksA/traR C4-type zinc finger HIMHAPGP_01341 118161.KB235922_gene4668 2.1e-109 402.5 Bacteria 3.5.1.53,6.3.5.1 ko:K01950,ko:K12251 ko00330,ko00760,ko01100,map00330,map00760,map01100 M00115 R00257,R01152 RC00010,RC00096,RC00100 ko00000,ko00001,ko00002,ko01000 Bacteria COG0388@1,COG0388@2 NA|NA|NA S hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds HIMHAPGP_01342 1122970.AUHC01000007_gene1772 4.3e-66 258.1 Alphaproteobacteria Bacteria 1NWS5@1224,2F4S8@1,2USNG@28211,33XEZ@2 NA|NA|NA HIMHAPGP_01343 1121124.JNIX01000005_gene1307 2.2e-204 719.2 Caulobacterales ko:K02014 ko00000,ko02000 1.B.14 Bacteria 1R533@1224,2KI6T@204458,2TVP0@28211,COG1629@1,COG4771@2 NA|NA|NA P TonB dependent receptor HIMHAPGP_01344 745310.G432_00565 1.2e-27 129.0 Proteobacteria MA20_14325 ko:K09780 ko00000 Bacteria 1NE0D@1224,COG2350@1,COG2350@2 NA|NA|NA S YCII-related domain HIMHAPGP_01345 745310.G432_00560 1.9e-122 445.7 Sphingomonadales qor 1.6.5.5 ko:K00344 ko00000,ko01000 Bacteria 1MWBD@1224,2K0EV@204457,2TS3Z@28211,COG0604@1,COG0604@2 NA|NA|NA C Alcohol dehydrogenase zinc-binding domain protein HIMHAPGP_01346 745310.G432_00555 9.7e-97 360.1 Sphingomonadales Bacteria 1RDMC@1224,2KCIZ@204457,2U8A2@28211,COG0346@1,COG0346@2 NA|NA|NA E lactoylglutathione lyase activity HIMHAPGP_01347 745310.G432_00550 3.3e-90 338.2 Sphingomonadales Bacteria 1MXBB@1224,2K0W0@204457,2TU4V@28211,COG1024@1,COG1024@2 NA|NA|NA I Belongs to the enoyl-CoA hydratase isomerase family HIMHAPGP_01348 745310.G432_00545 1.2e-147 529.3 Sphingomonadales Bacteria 1MV3V@1224,2JZX0@204457,2TR0I@28211,COG0726@1,COG0726@2 NA|NA|NA G Polysaccharide deacetylase HIMHAPGP_01349 1248760.ANFZ01000012_gene53 4.2e-115 421.0 Sphingomonadales Bacteria 1MVQW@1224,2K2ZA@204457,2TTD0@28211,COG1028@1,COG1028@2 NA|NA|NA IQ KR domain HIMHAPGP_01350 745310.G432_00535 4.3e-33 147.1 Sphingomonadales Bacteria 1N2MU@1224,2EBHU@1,2K746@204457,2UDTV@28211,335I9@2 NA|NA|NA S REDY-like protein HapK HIMHAPGP_01351 745310.G432_00530 1.4e-112 413.3 Sphingomonadales iaaH 3.5.1.86,6.3.5.6,6.3.5.7 ko:K02433,ko:K18541,ko:K21801 ko00380,ko00627,ko00970,ko01100,ko01120,map00380,map00627,map00970,map01100,map01120 R03905,R04212,R05783 RC00010,RC00358 ko00000,ko00001,ko01000,ko03029 Bacteria 1MUVQ@1224,2KCM0@204457,2TU3V@28211,COG0154@1,COG0154@2 NA|NA|NA J Amidase HIMHAPGP_01352 745310.G432_00525 2.2e-225 788.1 Sphingomonadales 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 R02539 RC00004,RC00014 ko00000,ko00001,ko01000 Bacteria 1MV1W@1224,2K2T7@204457,2TRVF@28211,COG1541@1,COG1541@2 NA|NA|NA H Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) HIMHAPGP_01353 745310.G432_00520 1.2e-145 523.1 Sphingomonadales Bacteria 1MX2N@1224,2K314@204457,2U4FG@28211,COG2079@1,COG2079@2 NA|NA|NA S MmgE/PrpD family HIMHAPGP_01354 745310.G432_00515 2.5e-122 445.7 Sphingomonadales Bacteria 1R5UM@1224,2K28A@204457,2U1F8@28211,COG2079@1,COG2079@2 NA|NA|NA S MmgE/PrpD family HIMHAPGP_01355 1248760.ANFZ01000012_gene47 2.5e-66 258.8 Sphingomonadales ko:K03710 ko00000,ko03000 Bacteria 1R4G0@1224,2K42Y@204457,2U3SJ@28211,COG2188@1,COG2188@2 NA|NA|NA K UTRA HIMHAPGP_01356 745310.G432_00505 6.9e-142 510.4 Sphingomonadales amacr Bacteria 1PRUN@1224,2K1PB@204457,2U183@28211,COG1804@1,COG1804@2 NA|NA|NA C CoA-transferase family III HIMHAPGP_01357 13689.BV96_03445 1.8e-100 372.9 Sphingomonadales cznB ko:K15727 ko00000,ko02000 8.A.1.2.1 Bacteria 1QMYR@1224,2K0FV@204457,2U69D@28211,COG0845@1,COG0845@2 NA|NA|NA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family HIMHAPGP_01358 627192.SLG_29180 5.5e-115 421.0 Sphingomonadales Bacteria 1N1Z2@1224,2K3MM@204457,2TVIP@28211,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor HIMHAPGP_01359 13689.BV96_03443 5.9e-90 337.4 Sphingomonadales Bacteria 1MY5Y@1224,2K2SR@204457,2VEVS@28211,COG0745@1,COG0745@2 NA|NA|NA T Transcriptional regulatory protein, C terminal HIMHAPGP_01360 666685.R2APBS1_2876 4.7e-57 227.6 Xanthomonadales cybB ko:K12262 ko00000 Bacteria 1RBP8@1224,1S563@1236,1XCYM@135614,COG3038@1,COG3038@2 NA|NA|NA C Prokaryotic cytochrome b561 HIMHAPGP_01361 1248916.ANFY01000008_gene2078 1.9e-169 602.1 Sphingomonadales phbA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1MU5G@1224,2JZW1@204457,2TQQ7@28211,COG0183@1,COG0183@2 NA|NA|NA I Belongs to the thiolase family HIMHAPGP_01363 1234595.C725_0439 1.6e-58 232.6 Alphaproteobacteria 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 Bacteria 1Q05U@1224,2U5IH@28211,COG0625@1,COG0625@2 NA|NA|NA O Glutathione S-transferase HIMHAPGP_01364 1248916.ANFY01000011_gene1283 2.3e-29 135.6 Sphingomonadales Bacteria 1RD0C@1224,2K560@204457,2U7AS@28211,COG3153@1,COG3153@2 NA|NA|NA S Acetyltransferase HIMHAPGP_01365 46429.BV95_01500 3e-62 245.0 Sphingomonadales MA20_44640 ko:K09986 ko00000 Bacteria 1RD5Q@1224,2K0YC@204457,2U7DA@28211,COG3816@1,COG3816@2 NA|NA|NA S protein conserved in bacteria HIMHAPGP_01366 745310.G432_15245 3.2e-48 198.4 Sphingomonadales nudL Bacteria 1RD2C@1224,2K3ZW@204457,2TV3Q@28211,COG0494@1,COG0494@2 NA|NA|NA L Nudix hydrolase HIMHAPGP_01367 1081640.AGFU01000011_gene1285 1.5e-113 416.4 Sphingomonadales cca 2.7.7.19,2.7.7.72 ko:K00970,ko:K00974 ko03013,ko03018,map03013,map03018 R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016,ko03019 Bacteria 1MVCS@1224,2K1SR@204457,2TRPZ@28211,COG0617@1,COG0617@2 NA|NA|NA J Polynucleotide adenylyltransferase HIMHAPGP_01368 1248916.ANFY01000003_gene530 3.4e-95 355.1 Sphingomonadales Bacteria 1MVF0@1224,2K0NV@204457,2TTR7@28211,COG2141@1,COG2141@2 NA|NA|NA C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases HIMHAPGP_01369 383381.EH30_09850 3.4e-28 131.7 Sphingomonadales ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 Bacteria 1MZGS@1224,2K4M2@204457,2UCUT@28211,COG3474@1,COG3474@2 NA|NA|NA C Cytochrome c HIMHAPGP_01370 1123368.AUIS01000009_gene2448 1.9e-41 177.2 Gammaproteobacteria ko:K02014 ko00000,ko02000 1.B.14 Bacteria 1QU6M@1224,1T1NT@1236,COG1629@1,COG1629@2 NA|NA|NA P Capsule assembly protein Wzi HIMHAPGP_01371 1090320.KB900605_gene2078 1.6e-46 193.0 Sphingomonadales 2.7.7.74 ko:K07281 ko00562,map00562 R09669 RC00002 ko00000,ko00001,ko01000 Bacteria 1RITD@1224,2K50F@204457,2UD1M@28211,COG1213@1,COG1213@2 NA|NA|NA M MobA-like NTP transferase domain HIMHAPGP_01372 1174684.EBMC1_14620 1e-139 503.4 Sphingomonadales Bacteria 1MWYR@1224,2K1KD@204457,2TSXW@28211,COG2271@1,COG2271@2 NA|NA|NA G COG0477 Permeases of the major facilitator superfamily HIMHAPGP_01373 1550073.JROH01000043_gene3176 2.4e-11 75.9 Sphingomonadales atpF ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 Bacteria 1N0P5@1224,2K57Z@204457,2U5DD@28211,COG0711@1,COG0711@2 NA|NA|NA C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) HIMHAPGP_01374 1549858.MC45_10065 1.1e-06 60.1 Sphingomonadales atpF ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 Bacteria 1MZGU@1224,2K5D0@204457,2UBVW@28211,COG0711@1,COG0711@2 NA|NA|NA C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) HIMHAPGP_01375 1429916.X566_05830 2.7e-19 100.9 Bradyrhizobiaceae atpE GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 Bacteria 1MZBU@1224,2UFPN@28211,3K02Q@41294,COG0636@1,COG0636@2 NA|NA|NA C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation HIMHAPGP_01376 1234595.C725_0443 3.2e-77 295.0 unclassified Alphaproteobacteria atpB ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 Bacteria 1MV87@1224,2TRNV@28211,4BPYN@82117,COG0356@1,COG0356@2 NA|NA|NA C it plays a direct role in the translocation of protons across the membrane HIMHAPGP_01377 1122135.KB893134_gene3828 3.1e-10 71.2 Alphaproteobacteria atpI ko:K02116 ko00000,ko00194 3.A.2.1 Bacteria 1NHIS@1224,2UFJJ@28211,COG5336@1,COG5336@2 NA|NA|NA S function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex HIMHAPGP_01378 1234595.C725_0451 1.3e-20 105.1 unclassified Alphaproteobacteria smc GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 ko:K03529 ko00000,ko03036 Bacteria 1MUAQ@1224,2TRQG@28211,4BPS7@82117,COG1196@1,COG1196@2 NA|NA|NA D Required for chromosome condensation and partitioning HIMHAPGP_01379 627192.SLG_18190 1.4e-95 355.9 Sphingomonadales Bacteria 1MUBX@1224,2KCC8@204457,2TSQN@28211,COG4805@1,COG4805@2 NA|NA|NA C protein conserved in bacteria HIMHAPGP_01380 1174684.EBMC1_16609 6.2e-133 480.7 Sphingomonadales Bacteria 1MUBH@1224,2K0KB@204457,2TSKH@28211,COG1960@1,COG1960@2 NA|NA|NA I Acyl-CoA dehydrogenase, N-terminal domain HIMHAPGP_01381 1502850.FG91_01487 6.7e-188 663.7 Proteobacteria Bacteria 1MWKN@1224,COG1629@1,COG4771@2 NA|NA|NA P COG1629 Outer membrane receptor proteins, mostly Fe transport HIMHAPGP_01382 199310.c4718 8.1e-134 483.8 Escherichia aslB GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0019538,GO:0043170,GO:0044238,GO:0051604,GO:0071704,GO:1901564 ko:K06871 ko00000 Bacteria 1MX3M@1224,1RN4R@1236,3XPDR@561,COG0641@1,COG0641@2 NA|NA|NA C protein maturation HIMHAPGP_01383 1446473.JHWH01000008_gene49 8.9e-72 276.6 Paracoccus ubiX GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0044237,GO:0044249,GO:0051186,GO:0051188 2.5.1.129 ko:K03186 ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 M00117 R01238,R02952,R03367,R04985,R04986,R11225 RC00391,RC00814,RC03392 ko00000,ko00001,ko00002,ko01000 Bacteria 1RA0P@1224,2PVMH@265,2U5GN@28211,COG0163@1,COG0163@2 NA|NA|NA H Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN HIMHAPGP_01384 935565.JAEM01000002_gene3609 5.7e-219 766.9 Paracoccus ubiD GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008694,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 4.1.1.61,4.1.1.98 ko:K03182,ko:K16239 ko00130,ko00627,ko01100,ko01110,ko01120,map00130,map00627,map01100,map01110,map01120 M00117 R01238,R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 iECO111_1330.ECO111_4669,iIT341.HP0396 Bacteria 1MU62@1224,2PU8F@265,2TTSQ@28211,COG0043@1,COG0043@2 NA|NA|NA H 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HIMHAPGP_01385 412597.AEPN01000024_gene675 3.6e-39 168.3 Paracoccus yhbT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 ko:K08303 ko05120,map05120 ko00000,ko00001,ko01000,ko01002 Bacteria 1RH2M@1224,2PVTR@265,2UA8H@28211,COG3154@1,COG3154@2 NA|NA|NA I SCP-2 sterol transfer family HIMHAPGP_01386 935848.JAEN01000022_gene2639 3.5e-156 557.8 Paracoccus yhbU ko:K08303 ko05120,map05120 ko00000,ko00001,ko01000,ko01002 Bacteria 1MUQG@1224,2PUYG@265,2TS5M@28211,COG0826@1,COG0826@2 NA|NA|NA O Peptidase family U32 HIMHAPGP_01387 1101189.AQUO01000001_gene2365 7.1e-116 423.7 Paracoccus yhbV Bacteria 1MWFW@1224,2PVXJ@265,2TSF0@28211,COG0826@1,COG0826@2 NA|NA|NA O Peptidase family U32 HIMHAPGP_01388 69279.BG36_04320 4.6e-60 237.3 Phyllobacteriaceae Bacteria 1RI0S@1224,2UBMJ@28211,43RG6@69277,COG2128@1,COG2128@2 NA|NA|NA S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity HIMHAPGP_01390 1123240.ATVO01000003_gene17 4.9e-30 137.5 Sphingomonadales folK 2.7.6.3,4.1.2.25 ko:K00950,ko:K13940 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503,R03504 RC00002,RC00017,RC00721,RC00943 ko00000,ko00001,ko00002,ko01000 Bacteria 1MZH8@1224,2K57H@204457,2U8D6@28211,COG0801@1,COG0801@2 NA|NA|NA H 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase HIMHAPGP_01391 745310.G432_04135 8.3e-114 416.8 Sphingomonadales aguB 3.5.1.53 ko:K12251 ko00330,ko01100,map00330,map01100 R01152 RC00096 ko00000,ko00001,ko01000 Bacteria 1MXG5@1224,2K0V3@204457,2TVCS@28211,COG0388@1,COG0388@2 NA|NA|NA S N-carbamoylputrescine amidase HIMHAPGP_01392 1248916.ANFY01000005_gene2845 1.5e-95 356.3 Sphingomonadales 3.5.3.12 ko:K10536 ko00330,ko01100,map00330,map01100 R01416 RC00177 ko00000,ko00001,ko01000 Bacteria 1MX65@1224,2K0B9@204457,2U0RR@28211,COG2957@1,COG2957@2 NA|NA|NA E Belongs to the agmatine deiminase family HIMHAPGP_01393 745310.G432_04010 1.2e-16 92.0 Sphingomonadales Bacteria 1NCTY@1224,2EIB4@1,2K6ZK@204457,2UHUB@28211,33C2I@2 NA|NA|NA S membrane HIMHAPGP_01394 745310.G432_09375 1.1e-76 293.1 Sphingomonadales ftsJ 2.1.1.166 ko:K02427 ko00000,ko01000,ko03009 Bacteria 1MW1C@1224,2K02A@204457,2TSBW@28211,COG0293@1,COG0293@2 NA|NA|NA J Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit HIMHAPGP_01395 745310.G432_09380 1.6e-91 343.2 Sphingomonadales ppx GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006793,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0040007,GO:0044237,GO:0044464,GO:0071944 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 R03409 RC00002 ko00000,ko00001,ko01000 Bacteria 1MV35@1224,2K1HK@204457,2TT2C@28211,COG0248@1,COG0248@2 NA|NA|NA FP exopolyphosphatase HIMHAPGP_01398 1234595.C725_1836 9.6e-55 219.5 unclassified Alphaproteobacteria fur ko:K03711 ko00000,ko03000 Bacteria 1RDWJ@1224,2U6ZS@28211,4BQAG@82117,COG0735@1,COG0735@2 NA|NA|NA K Belongs to the Fur family HIMHAPGP_01399 13689.BV96_02658 2e-49 201.8 Sphingomonadales mucR Bacteria 1RGUW@1224,2K4EY@204457,2U99M@28211,COG4957@1,COG4957@2 NA|NA|NA K Transcriptional regulator HIMHAPGP_01400 194867.ALBQ01000009_gene2304 4.4e-24 117.9 Sphingomonadales rimI GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008999,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0017189,GO:0018193,GO:0018194,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564 2.3.1.128,2.3.1.234 ko:K01409,ko:K03789,ko:K14742 R10648 RC00070,RC00416 ko00000,ko01000,ko03009,ko03016 Bacteria 1RIE6@1224,2K616@204457,2UF5C@28211,COG0454@1,COG0456@2 NA|NA|NA K Acetyltransferase HIMHAPGP_01401 1122970.AUHC01000008_gene123 5.1e-20 104.8 Sphingomonadales yeaZ GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 ko:K01409,ko:K14742 R10648 RC00070,RC00416 ko00000,ko01000,ko03016 Bacteria 1MXPH@1224,2K59A@204457,2TTM2@28211,COG1214@1,COG1214@2 NA|NA|NA O peptidase M22 HIMHAPGP_01402 1248916.ANFY01000010_gene374 2.4e-64 251.9 Sphingomonadales ko:K09019 ko00240,ko01100,map00240,map01100 R09289 RC00087 ko00000,ko00001,ko01000 Bacteria 1R9VX@1224,2K16Z@204457,2U5B0@28211,COG0778@1,COG0778@2 NA|NA|NA C Nitroreductase family HIMHAPGP_01403 1123269.NX02_13950 2.3e-64 251.9 Sphingomonadales nifU Bacteria 1MVQ1@1224,2K0IN@204457,2TUD1@28211,COG0694@1,COG0694@2 NA|NA|NA O COG0694 Thioredoxin-like proteins and domains HIMHAPGP_01404 317655.Sala_1234 9e-30 136.7 Sphingomonadales uspA Bacteria 1R9XB@1224,2K49I@204457,2U59E@28211,COG0589@1,COG0589@2 NA|NA|NA T Universal stress protein HIMHAPGP_01405 1234595.C725_0662 1.5e-27 129.8 Alphaproteobacteria Bacteria 1RA6M@1224,2C0PG@1,2U5UJ@28211,330E3@2 NA|NA|NA S Domain of unknown function (DUF4136) HIMHAPGP_01409 314256.OG2516_13926 3.2e-15 89.0 Oceanicola Bacteria 1Q551@1224,2EGQ7@1,2PFTN@252301,2VBIS@28211,33AGD@2 NA|NA|NA HIMHAPGP_01410 555793.WSK_0778 4.3e-139 501.1 Sphingomonadales 1.1.1.1 ko:K00001 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 Bacteria 1MUK4@1224,2K1CS@204457,2TU1G@28211,COG1062@1,COG1062@2 NA|NA|NA C Zinc-binding dehydrogenase HIMHAPGP_01411 1125973.JNLC01000014_gene2413 1.3e-52 213.8 Bradyrhizobiaceae Bacteria 1MXXU@1224,2TQJJ@28211,3JWAT@41294,COG0628@1,COG0628@2 NA|NA|NA S AI-2E family transporter HIMHAPGP_01413 685778.AORL01000019_gene1754 4.2e-128 464.9 Sphingomonadales 2.7.13.3 ko:K07653,ko:K18351 ko01502,ko02020,map01502,map02020 M00460,M00651,M00658 ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022 Bacteria 1MX6R@1224,2K1P6@204457,2TS9N@28211,COG0642@1,COG0642@2 NA|NA|NA T Histidine kinase HIMHAPGP_01414 1123269.NX02_27600 3.7e-85 320.9 Sphingomonadales Bacteria 1N0YI@1224,2K0M9@204457,2TSV8@28211,COG0745@1,COG0745@2 NA|NA|NA T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain HIMHAPGP_01415 1502851.FG93_03491 1.2e-68 266.5 Bradyrhizobiaceae metG GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 1MUBY@1224,2TQKA@28211,3JS60@41294,COG0143@1,COG0143@2 NA|NA|NA J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation HIMHAPGP_01416 666509.RCA23_c29420 7e-66 258.1 Alphaproteobacteria nhaA ko:K03313 ko00000,ko02000 2.A.33.1 Bacteria 1MW15@1224,2TSI5@28211,COG3004@1,COG3004@2 NA|NA|NA P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons HIMHAPGP_01417 745310.G432_00635 2.5e-104 385.2 Sphingomonadales ycfH GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575 ko:K03424 ko00000,ko01000 Bacteria 1MUC0@1224,2K0X6@204457,2TS88@28211,COG0084@1,COG0084@2 NA|NA|NA L LuxR family transcriptional regulator HIMHAPGP_01418 1123269.NX02_12760 7.2e-77 293.9 Sphingomonadales phnP 2.3.1.181,3.1.4.55 ko:K03801,ko:K06167 ko00440,ko00785,ko01100,map00440,map00785,map01100 R07766,R07769,R10205 RC00039,RC00296,RC00992,RC02867 ko00000,ko00001,ko01000 Bacteria 1MVJH@1224,2K1KQ@204457,2TQQN@28211,COG1235@1,COG1235@2 NA|NA|NA S COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I HIMHAPGP_01420 114615.BRADO6726 9.3e-42 176.4 Bradyrhizobiaceae MA20_19855 Bacteria 1RHRD@1224,2U9AT@28211,3JYWT@41294,COG3631@1,COG3631@2 NA|NA|NA S SnoaL-like domain HIMHAPGP_01423 1248916.ANFY01000006_gene2021 7.2e-178 630.9 Sphingomonadales fliC ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 ko00000,ko00001,ko02035 Bacteria 1MV1N@1224,2K02D@204457,2TT8X@28211,COG1344@1,COG1344@2 NA|NA|NA N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella HIMHAPGP_01424 1123240.ATVO01000005_gene1681 2.4e-44 185.7 Sphingomonadales MA20_43745 2.1.1.191,5.4.99.23,5.4.99.28,5.4.99.29 ko:K06177,ko:K06180,ko:K06969 ko00000,ko01000,ko03009,ko03016 Bacteria 1MVJ5@1224,2K0XZ@204457,2TSCG@28211,COG0564@1,COG0564@2 NA|NA|NA J Pseudouridine synthase HIMHAPGP_01427 1331060.RLDS_26830 6.2e-26 124.0 Sphingomonadales flgB ko:K02387 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 1MZ8P@1224,2KDMA@204457,2UA68@28211,COG1815@1,COG1815@2 NA|NA|NA N Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body HIMHAPGP_01428 1234595.C725_0097 1.2e-35 156.0 Proteobacteria flgC ko:K02388 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 1REA7@1224,COG1558@1,COG1558@2 NA|NA|NA N Belongs to the flagella basal body rod proteins family HIMHAPGP_01429 1550073.JROH01000018_gene480 4.1e-13 81.3 Sphingomonadales flgD GO:0001539,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044424,GO:0044444,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588 ko:K02389,ko:K02390 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 1MXCG@1224,2K5HS@204457,2U3ZF@28211,COG1843@1,COG1843@2 NA|NA|NA N Required for flagellar hook formation. May act as a scaffolding protein HIMHAPGP_01430 1248916.ANFY01000017_gene1504 1.9e-95 356.3 Sphingomonadales flgE ko:K02390 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 1MU5J@1224,2KD3N@204457,2TSF2@28211,COG1749@1,COG1749@2 NA|NA|NA N Flagellar basal body rod protein HIMHAPGP_01432 13690.CP98_03447 1.1e-29 136.0 Sphingomonadales fnrL ko:K01420 ko00000,ko03000 Bacteria 1MVGE@1224,2K40D@204457,2TV0E@28211,COG0664@1,COG0664@2 NA|NA|NA K CRP FNR family HIMHAPGP_01433 1030157.AFMP01000036_gene2553 1.1e-76 293.1 Sphingomonadales ompW ko:K07275 ko00000 Bacteria 1NUZJ@1224,2K2CV@204457,2TRGI@28211,COG3047@1,COG3047@2 NA|NA|NA M OmpW family HIMHAPGP_01434 627192.SLG_38310 5.7e-138 497.7 Sphingomonadales hemN GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.98.3 ko:K02495 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R06895 RC00884 ko00000,ko00001,ko00002,ko01000 iECIAI39_1322.ECIAI39_3134,iZ_1308.Z5403 Bacteria 1MV1I@1224,2K1GX@204457,2TRKT@28211,COG0635@1,COG0635@2 NA|NA|NA H Belongs to the anaerobic coproporphyrinogen-III oxidase family HIMHAPGP_01435 1030157.AFMP01000065_gene1171 6.6e-129 467.6 Sphingomonadales mgtE ko:K06213 ko00000,ko02000 1.A.26.1 Bacteria 1MW24@1224,2K0AK@204457,2TRWK@28211,COG2239@1,COG2239@2 NA|NA|NA P Acts as a magnesium transporter HIMHAPGP_01436 1123240.ATVO01000005_gene1738 5.6e-20 104.0 Sphingomonadales MA20_36070 Bacteria 1N054@1224,2K5VN@204457,2UBY1@28211,COG5458@1,COG5458@2 NA|NA|NA S Protein of unknown function (DUF1489) HIMHAPGP_01437 392499.Swit_4419 3e-36 157.9 Sphingomonadales modE ko:K02019,ko:K05772 ko02010,map02010 M00186 ko00000,ko00001,ko00002,ko02000,ko03000 3.A.1.6.2,3.A.1.6.4 Bacteria 1P9SX@1224,2K60A@204457,2UC9Q@28211,COG2005@1,COG2005@2 NA|NA|NA S Bacterial regulatory helix-turn-helix protein, lysR family HIMHAPGP_01438 1144305.PMI02_04515 6.5e-29 134.0 Sphingomonadales Bacteria 1N7EV@1224,2F929@1,2K6AB@204457,2UINC@28211,341DY@2 NA|NA|NA HIMHAPGP_01439 1123269.NX02_21045 1.5e-17 96.7 Sphingomonadales Bacteria 1N374@1224,2K1A2@204457,2UDAB@28211,COG3595@1,COG3595@2 NA|NA|NA S Putative auto-transporter adhesin, head GIN domain HIMHAPGP_01440 1248916.ANFY01000003_gene709 3.8e-15 86.7 Sphingomonadales carD GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0040007,GO:0042594,GO:0044419,GO:0050896,GO:0051704,GO:0051716,GO:0071496 ko:K07736 ko00000,ko03000 Bacteria 1MWI2@1224,2K0TA@204457,2TTVP@28211,COG1329@1,COG1329@2 NA|NA|NA K CarD family transcriptional regulator HIMHAPGP_01441 1123269.NX02_07270 4.9e-42 177.6 Sphingomonadales ko:K09950 ko00000 Bacteria 1RFBI@1224,2K5TK@204457,2UJE0@28211,COG3495@1,COG3495@2 NA|NA|NA S Protein of unknown function (DUF3299) HIMHAPGP_01442 1123269.NX02_07255 1.5e-183 649.0 Sphingomonadales Bacteria 1MVAF@1224,2K0Q2@204457,2TTYC@28211,COG1228@1,COG1228@2 NA|NA|NA Q COG1228 Imidazolonepropionase and related amidohydrolases HIMHAPGP_01443 1432050.IE4771_CH02075 1.6e-53 215.7 Rhizobiaceae Bacteria 1MZXE@1224,2U7TP@28211,4BEFA@82115,COG1846@1,COG1846@2 NA|NA|NA K helix_turn_helix multiple antibiotic resistance protein HIMHAPGP_01444 670307.HYPDE_28268 1.5e-50 205.7 Hyphomicrobiaceae Bacteria 1RF85@1224,2UBB2@28211,3N8XD@45401,COG1018@1,COG1018@2 NA|NA|NA C Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress HIMHAPGP_01446 1379701.JPJC01000194_gene771 5.6e-179 633.6 Sphingomonadales pyrG GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1276,iECO103_1326.ECO103_3323,iNJ661.Rv1699,iPC815.YPO3377 Bacteria 1MUIT@1224,2K005@204457,2TS4Y@28211,COG0504@1,COG0504@2 NA|NA|NA F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates HIMHAPGP_01447 1234595.C725_0510 1.6e-177 629.0 unclassified Alphaproteobacteria proS GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iJN678.proS Bacteria 1MU7E@1224,2TQQ4@28211,4BPCR@82117,COG0442@1,COG0442@2 NA|NA|NA J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) HIMHAPGP_01448 1248916.ANFY01000009_gene162 1.9e-151 542.3 Sphingomonadales lolC ko:K02004,ko:K09808 ko02010,map02010 M00255,M00258 ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.125 Bacteria 1MVV7@1224,2K03V@204457,2TRBX@28211,COG4591@1,COG4591@2 NA|NA|NA M ABC-type transport system, involved in lipoprotein release, permease component HIMHAPGP_01449 1081640.AGFU01000017_gene1849 2.4e-82 312.0 Sphingomonadales lolD GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006807,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008152,GO:0015031,GO:0015399,GO:0015405,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0022804,GO:0022857,GO:0030554,GO:0031224,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0042157,GO:0042160,GO:0042623,GO:0042626,GO:0042886,GO:0042953,GO:0043167,GO:0043168,GO:0043170,GO:0043190,GO:0043492,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0045184,GO:0051179,GO:0051234,GO:0051641,GO:0055085,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0072657,GO:0089705,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1902495,GO:1904949,GO:1990351,GO:1990778 ko:K09810 ko02010,map02010 M00255 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.125 Bacteria 1MVSQ@1224,2K04P@204457,2TSBE@28211,COG1136@1,COG1136@2 NA|NA|NA V Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner HIMHAPGP_01450 1248916.ANFY01000005_gene2709 3e-62 245.4 Sphingomonadales ko:K03566 ko02026,map02026 ko00000,ko00001,ko03000 Bacteria 1MWY0@1224,2K1M3@204457,2U2F2@28211,COG0583@1,COG0583@2 NA|NA|NA K Transcriptional regulator HIMHAPGP_01451 1090320.KB900605_gene547 9.4e-39 166.4 Sphingomonadales apaG ko:K06195 ko00000 Bacteria 1MZ2Z@1224,2K4GR@204457,2U9JM@28211,COG2967@1,COG2967@2 NA|NA|NA P protein affecting Mg2 Co2 transport HIMHAPGP_01452 1248916.ANFY01000005_gene2707 1.3e-165 589.3 Sphingomonadales metZ GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.48,4.4.1.8 ko:K01739,ko:K01760,ko:K10764 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04941,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00382,RC00420,RC00488,RC00710,RC01245,RC02303,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv0391 Bacteria 1MU57@1224,2K056@204457,2TTMF@28211,COG0626@1,COG0626@2 NA|NA|NA E Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide HIMHAPGP_01453 1123240.ATVO01000004_gene1116 4.5e-53 214.5 Sphingomonadales btuE 1.11.1.9 ko:K00432 ko00480,ko00590,ko04918,map00480,map00590,map04918 R00274,R07034,R07035 RC00011,RC00982 ko00000,ko00001,ko01000 Bacteria 1RD1R@1224,2K4N0@204457,2TU17@28211,COG0386@1,COG0386@2 NA|NA|NA O Glutathione peroxidase HIMHAPGP_01455 1292034.OR37_02261 1e-85 323.2 Caulobacterales Bacteria 1MY3D@1224,2KGBV@204458,2TTKG@28211,COG0745@1,COG0745@2 NA|NA|NA K response regulator HIMHAPGP_01457 1248916.ANFY01000009_gene276 2.5e-226 791.2 Sphingomonadales nuoF GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 ko:K00334,ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 1MV8F@1224,2JZYB@204457,2TRAH@28211,COG1894@1,COG1894@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HIMHAPGP_01458 1123240.ATVO01000003_gene499 2.2e-81 308.5 Sphingomonadales nuoE GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3,1.6.99.3 ko:K00334,ko:K00335,ko:K03943 ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016 M00143,M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1,3.D.1.6 Bacteria 1MWS2@1224,2K18U@204457,2TSEJ@28211,COG1905@1,COG1905@2 NA|NA|NA C NADH dehydrogenase HIMHAPGP_01459 1248916.ANFY01000009_gene280 1e-168 599.7 Sphingomonadales nuoD GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00333,ko:K13378 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 1MVIN@1224,2K0QX@204457,2TQZ0@28211,COG0649@1,COG0649@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient HIMHAPGP_01460 1123240.ATVO01000003_gene503 4e-73 281.2 Sphingomonadales nuoC GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 1MX4B@1224,2K0IR@204457,2TSMT@28211,COG0852@1,COG0852@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient HIMHAPGP_01461 1248916.ANFY01000009_gene282 1.1e-81 309.3 Sphingomonadales nuoB GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3,1.6.99.3 ko:K00331,ko:K03940 ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016 M00143,M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1,3.D.1.6 Bacteria 1MUI2@1224,2K0KE@204457,2TQK3@28211,COG0377@1,COG0377@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient HIMHAPGP_01464 84531.JMTZ01000030_gene157 4.8e-65 254.2 Xanthomonadales spoT 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 Bacteria 1RGUA@1224,1S3WT@1236,1XAHX@135614,COG0317@1,COG0317@2 NA|NA|NA KT HD domain HIMHAPGP_01465 279238.Saro_2799 4.4e-91 340.9 Sphingomonadales MA20_30730 ko:K07018 ko00000 Bacteria 1MUDY@1224,2JZVR@204457,2TRMI@28211,COG2945@1,COG2945@2 NA|NA|NA S Alpha Beta HIMHAPGP_01466 1234595.C725_0231 1.9e-83 316.2 unclassified Alphaproteobacteria nifS GO:0000096,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006464,GO:0006520,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0018282,GO:0018283,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0031071,GO:0031163,GO:0031974,GO:0031981,GO:0032324,GO:0034641,GO:0036211,GO:0042278,GO:0042802,GO:0042803,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043545,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0046983,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0065003,GO:0070013,GO:0071704,GO:0071840,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 Bacteria 1MU1C@1224,2TSQE@28211,4BPVP@82117,COG1104@1,COG1104@2 NA|NA|NA E Aminotransferase class-V HIMHAPGP_01467 1030157.AFMP01000008_gene3262 4.7e-80 305.1 Sphingomonadales iscS 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 Bacteria 1MU1C@1224,2K05P@204457,2TSQE@28211,COG1104@1,COG1104@2 NA|NA|NA E overlaps another CDS with the same product name HIMHAPGP_01468 392499.Swit_0053 1.5e-26 125.6 Sphingomonadales fdxB ko:K04755 ko00000 Bacteria 1RHDC@1224,2K5X1@204457,2U97J@28211,COG0633@1,COG0633@2 NA|NA|NA C Ferredoxin HIMHAPGP_01469 452662.SJA_C1-02870 3e-161 575.1 Sphingomonadales Bacteria 1MU48@1224,2K0BI@204457,2TQT0@28211,COG0841@1,COG0841@2 NA|NA|NA V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family HIMHAPGP_01470 1030157.AFMP01000004_gene1954 3.1e-90 339.0 Sphingomonadales Bacteria 1MXGH@1224,2K0EM@204457,2U18A@28211,COG0845@1,COG0845@2 NA|NA|NA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family HIMHAPGP_01471 518766.Rmar_0122 1.4e-16 92.0 Bacteroidetes Bacteria 4NVBV@976,COG2261@1,COG2261@2 NA|NA|NA S Transglycosylase associated protein HIMHAPGP_01472 935863.AWZR01000002_gene826 9.1e-50 203.8 Xanthomonadales bp26 GO:0005575,GO:0005623,GO:0042597,GO:0044464 ko:K09807 ko00000 Bacteria 1RH7T@1224,1RP7T@1236,1X44K@135614,COG2968@1,COG2968@2 NA|NA|NA S Protein of unknown function (DUF541) HIMHAPGP_01473 1248916.ANFY01000011_gene1203 6.5e-60 236.9 Sphingomonadales nrdR GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 ko:K07738 ko00000,ko03000 Bacteria 1RE7V@1224,2K3W4@204457,2U75W@28211,COG1327@1,COG1327@2 NA|NA|NA K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes HIMHAPGP_01475 1248916.ANFY01000011_gene1205 5.7e-191 673.7 Sphingomonadales glyA GO:0001505,GO:0003674,GO:0003824,GO:0004372,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006730,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016742,GO:0017144,GO:0019752,GO:0042133,GO:0042136,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUIS@1224,2K0BB@204457,2TQKT@28211,COG0112@1,COG0112@2 NA|NA|NA E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism HIMHAPGP_01476 1248916.ANFY01000011_gene1206 4.5e-44 184.1 Sphingomonadales rpiB GO:0003674,GO:0003824,GO:0004751,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 2.1.1.222,2.1.1.64,5.3.1.26,5.3.1.6 ko:K00568,ko:K01808,ko:K01819 ko00030,ko00051,ko00052,ko00130,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00052,map00130,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00117,M00165,M00167 R01056,R03240,R04988,R05614,R08769,R08781,R09030 RC00003,RC00376,RC00392,RC00434,RC01895 ko00000,ko00001,ko00002,ko01000 Bacteria 1RHBF@1224,2K4KN@204457,2U94R@28211,COG0698@1,COG0698@2 NA|NA|NA G Ribose 5-phosphate isomerase HIMHAPGP_01477 392499.Swit_3823 1.5e-117 429.1 Sphingomonadales hemA 2.3.1.29,2.3.1.37,2.3.1.47 ko:K00639,ko:K00643,ko:K00652 ko00260,ko00780,ko00860,ko01100,ko01110,map00260,map00780,map00860,map01100,map01110 M00123,M00573,M00577 R00371,R00830,R03210,R10124 RC00004,RC00039,RC00394,RC02725,RC02815 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 1MVVH@1224,2K08Q@204457,2TQXI@28211,COG0156@1,COG0156@2 NA|NA|NA E 5-aminolevulinic acid synthase HIMHAPGP_01478 292.DM42_5334 1.1e-65 257.7 Burkholderiaceae Bacteria 1K6IJ@119060,1MY4Y@1224,2VRGQ@28216,COG1680@1,COG1680@2 NA|NA|NA V PFAM beta-lactamase HIMHAPGP_01479 1248916.ANFY01000011_gene1210 7.5e-109 400.6 Sphingomonadales hibch 3.1.2.4,4.2.1.17 ko:K01692,ko:K05605 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01200,map01212 M00013,M00032,M00087 R03026,R03045,R03158,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05064,R05595,R06411,R06412,R06942,R08093 RC00004,RC00014,RC00137,RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 Bacteria 1MU0B@1224,2K1J0@204457,2TQW3@28211,COG1024@1,COG1024@2 NA|NA|NA I enoyl-CoA hydratase HIMHAPGP_01480 1248916.ANFY01000011_gene1211 5.7e-32 144.1 Sphingomonadales Bacteria 1RBET@1224,2K8CX@204457,2U5TM@28211,COG2050@1,COG2050@2 NA|NA|NA Q Thioesterase superfamily HIMHAPGP_01481 13689.BV96_01713 4.5e-90 337.8 Sphingomonadales murI 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 R00260 RC00302 ko00000,ko00001,ko01000,ko01011 Bacteria 1NAI2@1224,2K1X9@204457,2TSR7@28211,COG0796@1,COG0796@2 NA|NA|NA M Provides the (R)-glutamate required for cell wall biosynthesis HIMHAPGP_01482 426355.Mrad2831_4338 9.8e-10 69.7 Methylobacteriaceae Bacteria 1JV3H@119045,1NCMD@1224,2UI8F@28211,COG3801@1,COG3801@2 NA|NA|NA S YjbR HIMHAPGP_01483 1234595.C725_1632 2e-186 659.1 unclassified Alphaproteobacteria phbC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 ko:K03821 ko00650,map00650 R04254 RC00004 ko00000,ko00001,ko01000 Bacteria 1MU68@1224,2TR7S@28211,4BPFM@82117,COG3243@1,COG3243@2 NA|NA|NA I Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus HIMHAPGP_01485 1081640.AGFU01000055_gene146 8.7e-210 736.1 Sphingomonadales yfdZ GO:0003674,GO:0003824,GO:0004021,GO:0006082,GO:0006090,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009078,GO:0009079,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019272,GO:0019752,GO:0030632,GO:0032787,GO:0042851,GO:0042852,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0047635,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.83 ko:K10206,ko:K14261 ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230 M00527 R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 iEcSMS35_1347.EcSMS35_2531,iSBO_1134.SBO_2405 Bacteria 1MWS8@1224,2K0GY@204457,2TRE3@28211,COG0436@1,COG0436@2 NA|NA|NA E Aminotransferase HIMHAPGP_01486 1449076.JOOE01000003_gene3481 1.1e-192 679.5 Sphingomonadales tldD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 ko:K03568 ko00000,ko01002 Bacteria 1MUSK@1224,2JZY8@204457,2TRSR@28211,COG0312@1,COG0312@2 NA|NA|NA S peptidase U62, modulator of DNA gyrase HIMHAPGP_01487 402881.Plav_1125 2.2e-30 139.0 Alphaproteobacteria Bacteria 1N208@1224,2UDE9@28211,COG1309@1,COG1309@2 NA|NA|NA K transcriptional regulator HIMHAPGP_01488 301.JNHE01000002_gene2401 2.7e-89 335.9 Gammaproteobacteria Bacteria 1MV6E@1224,1RYQD@1236,COG3917@1,COG3917@2 NA|NA|NA Q 2-hydroxychromene-2-carboxylate isomerase HIMHAPGP_01489 1112212.JH584235_gene2540 1.3e-95 356.7 Sphingomonadales 3.1.26.11 ko:K00784 ko03013,map03013 ko00000,ko00001,ko01000,ko03016 Bacteria 1R64Z@1224,2K2ZH@204457,2U0BA@28211,COG1234@1,COG1234@2 NA|NA|NA S Beta-lactamase superfamily domain HIMHAPGP_01490 69395.JQLZ01000002_gene1253 1.2e-274 952.6 Alphaproteobacteria 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 Bacteria 1MV92@1224,2TTXG@28211,COG3119@1,COG3119@2 NA|NA|NA P Arylsulfatase HIMHAPGP_01491 392499.Swit_0013 8.4e-87 327.4 Sphingomonadales alr GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0006022,GO:0006023,GO:0006024,GO:0006082,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008784,GO:0009058,GO:0009059,GO:0009078,GO:0009079,GO:0009252,GO:0009273,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0019842,GO:0030170,GO:0030203,GO:0030632,GO:0034645,GO:0036094,GO:0036361,GO:0040007,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044281,GO:0044283,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0047661,GO:0048037,GO:0050662,GO:0070279,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 R00401 RC00285 ko00000,ko00001,ko01000,ko01011 Bacteria 1MV0Q@1224,2K0BU@204457,2TQKD@28211,COG0787@1,COG0787@2 NA|NA|NA E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids HIMHAPGP_01492 279238.Saro_0670 2.1e-35 157.1 Alphaproteobacteria 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 R00578 RC00010 ko00000,ko00001,ko01000,ko01002 Bacteria 1NDEB@1224,2UKEA@28211,COG0367@1,COG0367@2 NA|NA|NA E asparagine synthase HIMHAPGP_01494 1110502.TMO_2235 1.5e-167 595.9 Rhodospirillales Bacteria 1MU0J@1224,2JRBK@204441,2TQXH@28211,COG2132@1,COG2132@2 NA|NA|NA Q Multicopper oxidase HIMHAPGP_01495 13690.CP98_03102 2.8e-69 268.9 Sphingomonadales copB ko:K07233 ko00000 Bacteria 1MXW6@1224,2K0JZ@204457,2U363@28211,COG3667@1,COG3667@2 NA|NA|NA P Copper resistance HIMHAPGP_01496 450851.PHZ_c2020 3.6e-160 571.2 Caulobacterales MA20_04655 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 Bacteria 1MVJC@1224,2KFKM@204458,2TQRA@28211,COG1960@1,COG1960@2 NA|NA|NA C Acyl-CoA dehydrogenase, middle domain HIMHAPGP_01498 1248916.ANFY01000007_gene2422 5.4e-94 350.9 Sphingomonadales lepB 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 ko00000,ko00001,ko01000,ko01002 Bacteria 1MXUF@1224,2K1V9@204457,2TR9N@28211,COG0681@1,COG0681@2 NA|NA|NA U Belongs to the peptidase S26 family HIMHAPGP_01499 1248916.ANFY01000007_gene2421 2.3e-56 224.9 Sphingomonadales acpS GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008897,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016780,GO:0018070,GO:0018193,GO:0018209,GO:0018215,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576 2.7.8.7,3.2.1.52 ko:K00997,ko:K01207 ko00520,ko00531,ko00770,ko01100,ko01501,map00520,map00531,map00770,map01100,map01501 M00628 R00022,R01625,R05963,R07809,R07810,R10831 RC00002,RC00049 ko00000,ko00001,ko00002,ko01000 Bacteria 1MZBF@1224,2K4ID@204457,2U77S@28211,COG0736@1,COG0736@2 NA|NA|NA I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein HIMHAPGP_01500 1030157.AFMP01000040_gene1410 1.6e-81 309.3 Sphingomonadales pdxJ GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 ko:K03474 ko00750,ko01100,map00750,map01100 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000 iAF1260.b2564,iAF987.Gmet_1885,iB21_1397.B21_02422,iBWG_1329.BWG_2328,iEC55989_1330.EC55989_2852,iECBD_1354.ECBD_1117,iECB_1328.ECB_02458,iECDH10B_1368.ECDH10B_2732,iECDH1ME8569_1439.ECDH1ME8569_2491,iECD_1391.ECD_02458,iECH74115_1262.ECH74115_3800,iECIAI1_1343.ECIAI1_2675,iECO103_1326.ECO103_3142,iECO111_1330.ECO111_3290,iECO26_1355.ECO26_3611,iECSE_1348.ECSE_2852,iECSP_1301.ECSP_3509,iECW_1372.ECW_m2792,iECs_1301.ECs3430,iEKO11_1354.EKO11_1169,iEcDH1_1363.EcDH1_1104,iEcE24377_1341.EcE24377A_2850,iEcHS_1320.EcHS_A2719,iEcolC_1368.EcolC_1113,iG2583_1286.G2583_3145,iJO1366.b2564,iJR904.b2564,iWFL_1372.ECW_m2792,iY75_1357.Y75_RS13390 Bacteria 1MU9W@1224,2K0T4@204457,2TTTF@28211,COG0854@1,COG0854@2 NA|NA|NA H Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate HIMHAPGP_01501 1123240.ATVO01000008_gene2428 1.1e-75 289.7 Sphingomonadales pyrE 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 Bacteria 1RIC5@1224,2K1QD@204457,2TUX2@28211,COG0461@1,COG0461@2 NA|NA|NA F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) HIMHAPGP_01502 1248916.ANFY01000008_gene2070 1.3e-110 406.4 Sphingomonadales Bacteria 1QURH@1224,2K2HF@204457,2U2ZX@28211,COG1462@1,COG1462@2 NA|NA|NA M protein involved in formation of curli polymers HIMHAPGP_01503 745310.G432_13950 6.2e-59 234.6 Sphingomonadales ydiY ko:K07283 ko00000 Bacteria 1MWI4@1224,2JZWU@204457,2U5G9@28211,COG3137@1,COG3137@2 NA|NA|NA M salt-induced outer membrane protein HIMHAPGP_01504 1150469.RSPPHO_01391 1.1e-20 107.5 Rhodospirillales rlmI 2.1.1.191,2.1.1.72 ko:K00571,ko:K06969 ko00000,ko01000,ko02048,ko03009 Bacteria 1MUGB@1224,2JPGZ@204441,2TUNR@28211,COG1092@1,COG1092@2 NA|NA|NA J S-adenosylmethionine-dependent methyltransferase HIMHAPGP_01505 990285.RGCCGE502_15315 6.2e-33 147.9 Rhizobiaceae Bacteria 1RF1Y@1224,2VGDQ@28211,4BNIY@82115,COG2067@1,COG2067@2 NA|NA|NA I long-chain fatty acid transport protein HIMHAPGP_01506 1123269.NX02_28905 7.3e-287 993.0 Sphingomonadales parC GO:0000819,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008150,GO:0008152,GO:0009330,GO:0009987,GO:0016020,GO:0016043,GO:0019897,GO:0019898,GO:0022402,GO:0030541,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0098813,GO:1901360,GO:1901363 5.99.1.3 ko:K02469,ko:K02621 ko00000,ko01000,ko02048,ko03032,ko03036,ko03400 Bacteria 1MURI@1224,2K0IA@204457,2TQRQ@28211,COG0188@1,COG0188@2 NA|NA|NA L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule HIMHAPGP_01507 685778.AORL01000015_gene2367 3.8e-43 181.8 Sphingomonadales recO GO:0008150,GO:0009314,GO:0009628,GO:0050896 2.6.99.2 ko:K03474,ko:K03584 ko00750,ko01100,ko03440,map00750,map01100,map03440 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000,ko03400 Bacteria 1MVEJ@1224,2K120@204457,2TTYW@28211,COG1381@1,COG1381@2 NA|NA|NA L Involved in DNA repair and RecF pathway recombination HIMHAPGP_01508 194867.ALBQ01000039_gene3126 7.4e-105 387.1 Sphingomonadales era ko:K03595 ko00000,ko03009,ko03029 Bacteria 1MUKT@1224,2K01W@204457,2TSHM@28211,COG1159@1,COG1159@2 NA|NA|NA S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism HIMHAPGP_01509 392499.Swit_0209 1.3e-61 243.0 Sphingomonadales rnc GO:0000287,GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019899,GO:0022613,GO:0032296,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 Bacteria 1MUQ6@1224,2K1G1@204457,2TTIA@28211,COG0571@1,COG0571@2 NA|NA|NA J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism HIMHAPGP_01510 1101189.AQUO01000001_gene1768 1.8e-35 156.4 Paracoccus lepB 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 ko00000,ko00001,ko01000,ko01002 Bacteria 1MXUF@1224,2PUVH@265,2TR9N@28211,COG0681@1,COG0681@2 NA|NA|NA U Belongs to the peptidase S26 family HIMHAPGP_01511 1248916.ANFY01000011_gene1269 4.2e-148 531.6 Sphingomonadales pgi GO:0001701,GO:0001704,GO:0001707,GO:0002262,GO:0002376,GO:0002637,GO:0002639,GO:0002682,GO:0002684,GO:0002697,GO:0002699,GO:0002700,GO:0002702,GO:0002791,GO:0002793,GO:0003674,GO:0003824,GO:0004347,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0005929,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0007275,GO:0007369,GO:0007498,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009410,GO:0009435,GO:0009438,GO:0009653,GO:0009790,GO:0009792,GO:0009888,GO:0009892,GO:0009987,GO:0010033,GO:0010243,GO:0010466,GO:0010594,GO:0010595,GO:0010605,GO:0010632,GO:0010634,GO:0010941,GO:0010951,GO:0014070,GO:0014072,GO:0016020,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0016866,GO:0017144,GO:0018130,GO:0019222,GO:0019242,GO:0019318,GO:0019320,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0019693,GO:0019752,GO:0019899,GO:0030162,GO:0030246,GO:0030334,GO:0030335,GO:0031090,GO:0031253,GO:0031323,GO:0031324,GO:0031625,GO:0031974,GO:0031981,GO:0032268,GO:0032269,GO:0032501,GO:0032502,GO:0032787,GO:0032879,GO:0032880,GO:0033500,GO:0034101,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0040012,GO:0040017,GO:0042180,GO:0042181,GO:0042221,GO:0042493,GO:0042592,GO:0042593,GO:0042866,GO:0042981,GO:0042995,GO:0043005,GO:0043009,GO:0043066,GO:0043067,GO:0043069,GO:0043086,GO:0043154,GO:0043209,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043278,GO:0043279,GO:0043281,GO:0043436,GO:0043523,GO:0043524,GO:0044092,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044389,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044441,GO:0044444,GO:0044446,GO:0044459,GO:0044463,GO:0044464,GO:0045861,GO:0046031,GO:0046034,GO:0046184,GO:0046185,GO:0046365,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048029,GO:0048332,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048598,GO:0048646,GO:0048729,GO:0048856,GO:0048872,GO:0048878,GO:0050708,GO:0050714,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051023,GO:0051024,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051156,GO:0051171,GO:0051172,GO:0051186,GO:0051188,GO:0051222,GO:0051223,GO:0051239,GO:0051240,GO:0051246,GO:0051248,GO:0051270,GO:0051272,GO:0051336,GO:0051346,GO:0052547,GO:0052548,GO:0055086,GO:0055114,GO:0060170,GO:0060255,GO:0060359,GO:0060548,GO:0061615,GO:0061620,GO:0061621,GO:0061718,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070201,GO:0071704,GO:0071944,GO:0072330,GO:0072347,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090087,GO:0090407,GO:0097458,GO:0098588,GO:0098590,GO:0120025,GO:0120038,GO:1901135,GO:1901137,GO:1901214,GO:1901215,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901698,GO:1903530,GO:1903532,GO:1904951,GO:2000116,GO:2000117,GO:2000145,GO:2000147 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1MUFP@1224,2K0KU@204457,2TQKP@28211,COG0166@1,COG0166@2 NA|NA|NA G Belongs to the GPI family HIMHAPGP_01512 1248916.ANFY01000011_gene1081 9.2e-67 260.0 Sphingomonadales 3.8.1.2 ko:K01560,ko:K07025 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 R05287 RC00697 ko00000,ko00001,ko01000 Bacteria 1RHAB@1224,2K2XU@204457,2U7PV@28211,COG1011@1,COG1011@2 NA|NA|NA S Hydrolase HIMHAPGP_01513 1088721.NSU_0620 2.9e-12 76.6 Bacteria rpmJ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02919 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria COG0257@1,COG0257@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL36 family HIMHAPGP_01514 1248916.ANFY01000011_gene1085 8.4e-138 496.9 Sphingomonadales Bacteria 1MUMN@1224,2K01Q@204457,2TREN@28211,COG2866@1,COG2866@2 NA|NA|NA E Carboxypeptidase HIMHAPGP_01515 1123269.NX02_28340 4.9e-93 347.4 Sphingomonadales gpmA GO:0001871,GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009986,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030246,GO:0030247,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031,GO:2001065 5.4.2.11 ko:K01834 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 Bacteria 1MUVE@1224,2K06W@204457,2TSQ0@28211,COG0588@1,COG0588@2 NA|NA|NA G Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily HIMHAPGP_01516 1090319.KE386571_gene2105 2.9e-60 238.0 Sphingomonadales purE GO:0003674,GO:0003824,GO:0004638,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0016853,GO:0016866,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034023,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 iETEC_1333.ETEC_0575,iJN746.PP_5336,iPC815.YPO3076,iUTI89_1310.UTI89_C0551 Bacteria 1RCWJ@1224,2K3Z8@204457,2U58D@28211,COG0041@1,COG0041@2 NA|NA|NA F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) HIMHAPGP_01517 1234595.C725_1570 2.2e-119 435.6 unclassified Alphaproteobacteria purK GO:0000166,GO:0003674,GO:0003824,GO:0004638,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016829,GO:0016830,GO:0016831,GO:0016874,GO:0016879,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034028,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.4.18 ko:K01589 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07404 RC01927 ko00000,ko00001,ko00002,ko01000 iECUMN_1333.ECUMN_0562,iYL1228.KPN_00477 Bacteria 1MU70@1224,2TRSV@28211,4BQ26@82117,COG0026@1,COG0026@2 NA|NA|NA F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) HIMHAPGP_01518 378806.STAUR_2006 6.9e-32 144.1 Myxococcales Bacteria 1MYIE@1224,2X4RP@28221,2YZG8@29,439FW@68525,COG0457@1,COG0457@2 NA|NA|NA S TPR repeat HIMHAPGP_01519 1123240.ATVO01000010_gene628 6.6e-49 200.3 Sphingomonadales ibpB GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0010035,GO:0010038,GO:0042221,GO:0042802,GO:0044424,GO:0044464,GO:0046688,GO:0050896,GO:0097501,GO:1990169 ko:K04080,ko:K04081,ko:K13993 ko04141,map04141 ko00000,ko00001,ko03110 Bacteria 1RH2X@1224,2K4JU@204457,2U96D@28211,COG0071@1,COG0071@2 NA|NA|NA O Belongs to the small heat shock protein (HSP20) family HIMHAPGP_01520 543728.Vapar_2217 1.3e-56 226.1 Comamonadaceae Bacteria 1RHYI@1224,2VSHT@28216,4AE6J@80864,COG3803@1,COG3803@2 NA|NA|NA S Bacterial protein of unknown function (DUF924) HIMHAPGP_01522 1007104.SUS17_1016 9.4e-62 243.4 Sphingomonadales rpoH GO:0000150,GO:0000976,GO:0000984,GO:0000985,GO:0000988,GO:0000990,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006310,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009009,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031421,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140097,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2001141 ko:K03089 ko00000,ko03021 Bacteria 1MVWR@1224,2K1G6@204457,2TR9Q@28211,COG0568@1,COG0568@2 NA|NA|NA K RNA polymerase sigma HIMHAPGP_01523 392499.Swit_4744 5.1e-188 664.5 Sphingomonadales Bacteria 1MU48@1224,2K0BI@204457,2TQT0@28211,COG0841@1,COG0841@2 NA|NA|NA V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family HIMHAPGP_01524 1550073.JROH01000008_gene1803 4.5e-105 388.3 Sphingomonadales Bacteria 1MX3G@1224,2K0FY@204457,2U15J@28211,COG2733@1,COG2733@2 NA|NA|NA S membrane HIMHAPGP_01525 1123240.ATVO01000003_gene531 7.9e-113 413.7 Alphaproteobacteria M1-763 Bacteria 1MX4H@1224,2TQUY@28211,COG0491@1,COG0491@2 NA|NA|NA S COG0491 Zn-dependent hydrolases, including glyoxylases HIMHAPGP_01526 1030157.AFMP01000059_gene2850 2.9e-25 122.1 Sphingomonadales Bacteria 1NMJF@1224,2DFXE@1,2K7AJ@204457,2UKCR@28211,2ZTK0@2 NA|NA|NA S PEP-CTERM motif HIMHAPGP_01527 1234595.C725_2514 2.2e-102 378.6 Alphaproteobacteria Bacteria 1MWGC@1224,2TSNX@28211,COG1028@1,COG1028@2 NA|NA|NA IQ short-chain dehydrogenase HIMHAPGP_01528 1123240.ATVO01000003_gene529 1.8e-77 296.6 Alphaproteobacteria hcaT GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.5.1.2 ko:K00286,ko:K05820 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000,ko02000 2.A.1.27 iECIAI39_1322.ECIAI39_2737,iEcSMS35_1347.EcSMS35_2688,iSFV_1184.SFV_2584,iSF_1195.SF2583,iS_1188.S2755 Bacteria 1MVZI@1224,2U5H1@28211,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily HIMHAPGP_01529 269796.Rru_A1038 1.1e-86 327.0 Rhodospirillales ko:K07001 ko00000 Bacteria 1MVHW@1224,2JPJG@204441,2TS4V@28211,COG1752@1,COG1752@2 NA|NA|NA S esterase of the alpha-beta hydrolase superfamily HIMHAPGP_01530 190650.CC_0580 1.6e-34 152.5 Caulobacterales ko:K03719,ko:K05800 ko00000,ko03000,ko03036 Bacteria 1RA2G@1224,2KJ98@204458,2TTD9@28211,COG1522@1,COG1522@2 NA|NA|NA K helix_turn_helix ASNC type HIMHAPGP_01531 1123240.ATVO01000004_gene1051 1.8e-107 396.0 Sphingomonadales astA 2.3.1.109 ko:K00673 ko00330,ko01100,map00330,map01100 R00832 RC00004,RC00064 ko00000,ko00001,ko01000 Bacteria 1MWHC@1224,2K0MB@204457,2TREF@28211,COG3138@1,COG3138@2 NA|NA|NA E arginine N-succinyltransferase HIMHAPGP_01532 1123240.ATVO01000004_gene1050 1.3e-159 569.7 Sphingomonadales astD GO:0003674,GO:0003824,GO:0004029,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.2.1.71 ko:K06447 ko00330,ko01100,map00330,map01100 R05049 RC00080 ko00000,ko00001,ko01000 iECABU_c1320.ECABU_c20030,iEcHS_1320.EcHS_A1829,ic_1306.c2146 Bacteria 1MV2I@1224,2K13M@204457,2TU8S@28211,COG1012@1,COG1012@2 NA|NA|NA C Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate HIMHAPGP_01533 1234595.C725_0782 1.6e-129 469.5 Alphaproteobacteria astB GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006807,GO:0008150,GO:0008152,GO:0009015,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016813,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 3.5.3.23 ko:K01484 ko00330,ko01100,map00330,map01100 R04189 RC00024 ko00000,ko00001,ko01000 iECH74115_1262.ECH74115_2463,iECSP_1301.ECSP_2313,iECs_1301.ECs2451,iG2583_1286.G2583_2191 Bacteria 1MUJV@1224,2U0HD@28211,COG3724@1,COG3724@2 NA|NA|NA E Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) HIMHAPGP_01534 279238.Saro_1115 1.1e-34 152.5 Sphingomonadales ko:K04755 ko00000 Bacteria 1N261@1224,2K5DE@204457,2UC7B@28211,COG0633@1,COG0633@2 NA|NA|NA C ferredoxin HIMHAPGP_01535 1449076.JOOE01000004_gene388 2.7e-58 231.9 Sphingomonadales alkA 3.2.2.21 ko:K01247 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 1MX9C@1224,2K0I0@204457,2TVJ7@28211,COG0122@1,COG0122@2 NA|NA|NA L COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase HIMHAPGP_01536 1112214.AHIS01000093_gene518 3.5e-66 258.5 Sphingomonadales spoU 2.1.1.185 ko:K03218,ko:K03437 ko00000,ko01000,ko03009,ko03016 Bacteria 1MWBE@1224,2K16F@204457,2TT4Y@28211,COG0566@1,COG0566@2 NA|NA|NA J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family HIMHAPGP_01537 1207058.L53_00185 9.5e-51 206.1 Hyphomonadaceae Bacteria 1N1D4@1224,2UBYV@28211,43XV9@69657,COG0346@1,COG0346@2 NA|NA|NA E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily HIMHAPGP_01539 1122611.KB903939_gene313 9.4e-60 238.4 Actinobacteria Bacteria 2H5BJ@201174,COG0515@1,COG0515@2,COG4403@1,COG4403@2 NA|NA|NA KLT Lanthionine synthetase C-like protein HIMHAPGP_01540 1123240.ATVO01000006_gene1307 4.6e-46 193.4 Sphingomonadales Bacteria 1MVEP@1224,2K0N2@204457,2TR50@28211,COG1196@1,COG1196@2 NA|NA|NA D nuclear chromosome segregation HIMHAPGP_01542 279238.Saro_1830 8.1e-40 169.5 Sphingomonadales phnA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 ko:K06193 ko01120,map01120 ko00000 Bacteria 1RGUU@1224,2K59J@204457,2UFDJ@28211,COG2824@1,COG2824@2 NA|NA|NA P PhnA protein HIMHAPGP_01545 314271.RB2654_15325 5e-41 175.3 Alphaproteobacteria Bacteria 1NVHG@1224,28PWR@1,2URVD@28211,2ZCGZ@2 NA|NA|NA HIMHAPGP_01549 1123240.ATVO01000005_gene2035 4.3e-152 545.0 Sphingomonadales ko:K03455,ko:K11747 ko00000,ko02000 2.A.37,2.A.37.1.2 Bacteria 1MV34@1224,2K1PS@204457,2TRC5@28211,COG0475@1,COG0475@2,COG1226@1,COG1226@2 NA|NA|NA P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family HIMHAPGP_01550 1549858.MC45_01665 2e-29 135.6 Sphingomonadales iscU ko:K04488 ko00000 Bacteria 1RDGB@1224,2K54B@204457,2U74A@28211,COG0822@1,COG0822@2 NA|NA|NA C NifU homolog involved in Fe-S cluster formation HIMHAPGP_01551 1522072.IL54_0166 2.5e-24 119.4 Sphingomonadales Bacteria 1RJRH@1224,2ANQE@1,2KEBA@204457,2UA8T@28211,33CW4@2 NA|NA|NA S Domain of unknown function (DUF4163) HIMHAPGP_01552 1248916.ANFY01000003_gene912 1.6e-121 443.0 Sphingomonadales cysS GO:0000166,GO:0001871,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030246,GO:0030247,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065 6.1.1.16,6.3.1.13 ko:K01883,ko:K15526 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 1MV8H@1224,2K19T@204457,2TQQ1@28211,COG0215@1,COG0215@2 NA|NA|NA J Belongs to the class-I aminoacyl-tRNA synthetase family HIMHAPGP_01553 1248916.ANFY01000003_gene911 1.6e-27 129.8 Sphingomonadales cvpA GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009403,GO:0009404,GO:0009987,GO:0016020,GO:0019748,GO:0044237,GO:0044249,GO:0044464,GO:0044550,GO:0071944 ko:K03558 ko00000 Bacteria 1REF7@1224,2K52S@204457,2VA4D@28211,COG1286@1,COG1286@2 NA|NA|NA S Colicin V production protein HIMHAPGP_01554 1007104.SUS17_331 8.4e-177 626.7 Sphingomonadales radA GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 ko:K04485 ko00000,ko03400 Bacteria 1MUJQ@1224,2K1F3@204457,2TS6F@28211,COG1066@1,COG1066@2 NA|NA|NA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function HIMHAPGP_01555 745310.G432_04055 2.1e-27 129.0 Alphaproteobacteria Bacteria 1NC0E@1224,2CHJ3@1,2UGT4@28211,332B4@2 NA|NA|NA HIMHAPGP_01556 1267005.KB911259_gene3867 9.2e-67 260.4 Hyphomicrobiaceae folP GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042221,GO:0042364,GO:0042398,GO:0042493,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046655,GO:0046656,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 iECO103_1326.ECO103_3924,iPC815.YPO3501 Bacteria 1MUIR@1224,2TTMG@28211,3N6U8@45401,COG0294@1,COG0294@2 NA|NA|NA H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives HIMHAPGP_01557 1192759.AKIB01000040_gene3579 6.6e-45 187.2 Sphingomonadales apt 2.4.2.7 ko:K00759 ko00230,ko01100,map00230,map01100 R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko04147 Bacteria 1MVZ6@1224,2K25N@204457,2TV7J@28211,COG0503@1,COG0503@2 NA|NA|NA F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis HIMHAPGP_01558 1247963.JPHU01000001_gene1965 1.1e-68 266.9 Alphaproteobacteria mtnP 2.4.2.28 ko:K00772 ko00270,ko01100,map00270,map01100 M00034 R01402 RC00063,RC02819 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUWW@1224,2TSN3@28211,COG0005@1,COG0005@2 NA|NA|NA F Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates HIMHAPGP_01559 1280946.HY29_14750 3.3e-72 278.5 Hyphomonadaceae Bacteria 1R5N9@1224,28JIP@1,2U95E@28211,2Z82C@2,43YH4@69657 NA|NA|NA S S1/P1 Nuclease HIMHAPGP_01560 745310.G432_10705 1.9e-140 505.8 Sphingomonadales mdeA 2.5.1.48,4.4.1.11,4.4.1.8 ko:K01739,ko:K01760,ko:K01761,ko:K10764 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00654,R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04941,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 Bacteria 1MU57@1224,2K1W3@204457,2TW14@28211,COG0626@1,COG0626@2 NA|NA|NA E Catalyzes the formation of methanethiol and 2-ocobutanoate from L-methionine HIMHAPGP_01561 1411123.JQNH01000001_gene44 1.7e-30 139.4 Alphaproteobacteria Bacteria 1RH69@1224,2U93B@28211,COG3247@1,COG3247@2 NA|NA|NA S Short repeat of unknown function (DUF308) HIMHAPGP_01562 1248916.ANFY01000007_gene2299 2.9e-76 292.4 Sphingomonadales Bacteria 1MW0B@1224,2K27V@204457,2TQSH@28211,COG0628@1,COG0628@2 NA|NA|NA S AI-2E family transporter HIMHAPGP_01563 1123269.NX02_25850 7.5e-201 706.4 Sphingomonadales argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 iJN678.argG,iSB619.SA_RS04675 Bacteria 1MV0Y@1224,2K0AN@204457,2TTGS@28211,COG0137@1,COG0137@2 NA|NA|NA E Belongs to the argininosuccinate synthase family. Type 1 subfamily HIMHAPGP_01564 62928.azo1779 1.3e-26 127.1 Betaproteobacteria ampD 3.5.1.28 ko:K01447,ko:K03806,ko:K11066 R04112 RC00064,RC00141 ko00000,ko01000,ko01011 Bacteria 1RDHU@1224,2VWQD@28216,COG3023@1,COG3023@2 NA|NA|NA V Ami_2 HIMHAPGP_01565 1248916.ANFY01000002_gene1320 1.9e-196 692.6 Sphingomonadales mrcB 2.4.1.129,3.4.16.4 ko:K05365,ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 GT51 Bacteria 1QTST@1224,2K0HX@204457,2TQQ8@28211,COG0744@1,COG0744@2 NA|NA|NA M penicillin-binding protein HIMHAPGP_01566 1112214.AHIS01000002_gene1822 3.9e-106 392.1 Sphingomonadales Bacteria 1QED4@1224,2EB2V@1,2K1M2@204457,2U3RZ@28211,3353M@2 NA|NA|NA S Domain of unknown function (DUF4403) HIMHAPGP_01567 1248916.ANFY01000010_gene404 1e-66 260.4 Sphingomonadales Bacteria 1QUNU@1224,2K09G@204457,2TW29@28211,COG2267@1,COG2267@2 NA|NA|NA I hydrolases or acyltransferases (alpha beta hydrolase superfamily) HIMHAPGP_01568 1550073.JROH01000026_gene1000 3e-149 535.0 Sphingomonadales Bacteria 1MY18@1224,2K07G@204457,2TU4T@28211,COG3853@1,COG3853@2 NA|NA|NA P Toxic anion resistance HIMHAPGP_01569 1248760.ANFZ01000012_gene38 5.6e-71 274.2 Sphingomonadales ko:K18930 ko00000 Bacteria 1N22A@1224,2KDBJ@204457,2TUDT@28211,COG0277@1,COG0277@2 NA|NA|NA C FAD binding domain HIMHAPGP_01570 745310.G432_00460 1e-145 523.1 Sphingomonadales Bacteria 1Q7MC@1224,2K2WQ@204457,2VCNW@28211,COG0388@1,COG0388@2 NA|NA|NA S Carbon-nitrogen hydrolase HIMHAPGP_01571 745310.G432_00455 8.7e-170 603.2 Sphingomonadales 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 Bacteria 1R41W@1224,2K2PR@204457,2U1RV@28211,COG0500@1,COG2226@2 NA|NA|NA Q Methylase involved in ubiquinone menaquinone biosynthesis HIMHAPGP_01572 745310.G432_00450 1.3e-35 156.0 Sphingomonadales Bacteria 1N9UY@1224,2E4NX@1,2KCH3@204457,2USV9@28211,32ZHQ@2 NA|NA|NA HIMHAPGP_01573 745310.G432_00435 2.1e-178 632.1 Sphingomonadales 1.2.1.3,1.2.99.10 ko:K00128,ko:K22445 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 Bacteria 1QIM4@1224,2K34Y@204457,2TU18@28211,COG1012@1,COG1012@2 NA|NA|NA C Aldehyde dehydrogenase family HIMHAPGP_01574 1248760.ANFZ01000012_gene22 6.3e-156 557.4 Sphingomonadales Bacteria 1RFX1@1224,2KEQT@204457,2U79Q@28211,COG0596@1,COG0596@2 NA|NA|NA S alpha/beta hydrolase fold HIMHAPGP_01575 1248916.ANFY01000010_gene390 1.1e-54 219.9 Sphingomonadales coaE GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24,3.2.2.23,4.2.99.18,5.4.99.23 ko:K00859,ko:K06180,ko:K10563 ko00770,ko01100,ko03410,map00770,map01100,map03410 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko03009,ko03400 Bacteria 1RCXT@1224,2K3YB@204457,2U765@28211,COG0237@1,COG0237@2 NA|NA|NA H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A HIMHAPGP_01576 1123240.ATVO01000009_gene849 9e-60 237.3 Sphingomonadales aroE GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 Bacteria 1MVH4@1224,2K1U1@204457,2TS99@28211,COG0169@1,COG0169@2 NA|NA|NA E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) HIMHAPGP_01577 1121033.AUCF01000003_gene3402 2.3e-49 202.2 Rhodospirillales maf GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030312,GO:0044464,GO:0047429,GO:0071944 1.1.1.25,2.1.1.190 ko:K00014,ko:K03215,ko:K06287 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000,ko03009 Bacteria 1RDA9@1224,2JS40@204441,2U9H5@28211,COG0424@1,COG0424@2 NA|NA|NA D Maf-like protein HIMHAPGP_01578 1030157.AFMP01000004_gene2041 3.7e-95 354.8 Sphingomonadales yqfL 2.7.11.33,2.7.4.28 ko:K09773 ko00000,ko01000 Bacteria 1MUHU@1224,2K0GA@204457,2TT66@28211,COG1806@1,COG1806@2 NA|NA|NA S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation HIMHAPGP_01579 745310.G432_10210 1.2e-114 419.9 Sphingomonadales hemE GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUG1@1224,2JZZP@204457,2TQQV@28211,COG0407@1,COG0407@2 NA|NA|NA H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III HIMHAPGP_01580 702113.PP1Y_AT18 1.1e-35 156.4 Sphingomonadales MA20_24805 ko:K08973 ko00000 Bacteria 1RHGS@1224,2K4J9@204457,2U987@28211,COG1981@1,COG1981@2 NA|NA|NA S membrane HIMHAPGP_01583 1248916.ANFY01000003_gene975 4.2e-44 184.1 Sphingomonadales acnA GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044262,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046459,GO:0046487,GO:0046872,GO:0046914,GO:0047456,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 iAPECO1_1312.APECO1_436,iECOK1_1307.ECOK1_1491,iECS88_1305.ECS88_1416,iJN746.PP_2112,iUMN146_1321.UM146_10390,iUTI89_1310.UTI89_C1547 Bacteria 1MU9T@1224,2K0CP@204457,2TT3T@28211,COG1048@1,COG1048@2 NA|NA|NA C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate HIMHAPGP_01584 1030157.AFMP01000040_gene1424 6.3e-46 191.0 Sphingomonadales ko:K03832 ko00000,ko02000 2.C.1.1 Bacteria 1REG7@1224,2AK5K@1,2K5AP@204457,2U8E6@28211,31AVG@2 NA|NA|NA HIMHAPGP_01585 261292.Nit79A3_1818 1.1e-35 156.8 Nitrosomonadales sca1 Bacteria 1PE8M@1224,2WDQ9@28216,3746R@32003,COG1196@1,COG1196@2 NA|NA|NA D PEP-CTERM motif HIMHAPGP_01586 1248916.ANFY01000017_gene1413 3.5e-235 820.8 Sphingomonadales MA20_27300 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 Bacteria 1MVAX@1224,2K212@204457,2TTB9@28211,COG4799@1,COG4799@2 NA|NA|NA I COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) HIMHAPGP_01587 1114964.L485_08390 1.1e-10 73.2 Sphingomonadales Bacteria 1NCMB@1224,2AI43@1,2K76K@204457,2UFPI@28211,318I3@2 NA|NA|NA HIMHAPGP_01588 702113.PP1Y_Mpl1986 4.1e-32 145.6 Sphingomonadales Bacteria 1RE5R@1224,2EDGC@1,2K1JN@204457,2U8YS@28211,337CJ@2 NA|NA|NA HIMHAPGP_01589 1280949.HAD_10780 1.9e-42 178.7 Alphaproteobacteria Bacteria 1MY83@1224,2VG7S@28211,COG3193@1,COG3193@2 NA|NA|NA S protein possibly involved in utilization of glycolate and propanediol HIMHAPGP_01590 1192759.AKIB01000061_gene2011 7e-234 817.0 Sphingomonadales copA GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0042802,GO:0044464,GO:0071944 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 Bacteria 1MU08@1224,2K0EB@204457,2TR80@28211,COG2217@1,COG2217@2 NA|NA|NA P P-type ATPase HIMHAPGP_01591 1030157.AFMP01000019_gene586 2.3e-42 178.3 Sphingomonadales hmrR ko:K19591 M00769 ko00000,ko00002,ko01504,ko03000 Bacteria 1RGX6@1224,2K4QY@204457,2U98F@28211,COG0789@1,COG0789@2 NA|NA|NA K MerR family transcriptional regulator HIMHAPGP_01592 1234595.C725_1076 5.3e-19 101.3 Alphaproteobacteria Bacteria 1N3B4@1224,2C2VU@1,2UCFR@28211,34305@2 NA|NA|NA HIMHAPGP_01593 450851.PHZ_c0730 1.2e-156 559.7 Caulobacterales yhjE ko:K03761,ko:K03762 ko00000,ko02000 2.A.1.6.2,2.A.1.6.4 Bacteria 1MU46@1224,2KFVF@204458,2TQVP@28211,COG0477@1,COG0477@2 NA|NA|NA EGP Sugar (and other) transporter HIMHAPGP_01594 1297863.APJF01000017_gene4370 6.2e-79 300.8 Bradyrhizobiaceae MA20_06735 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 Bacteria 1MXHV@1224,2TTEG@28211,3JT1F@41294,COG1024@1,COG1024@2 NA|NA|NA I Belongs to the enoyl-CoA hydratase isomerase family HIMHAPGP_01595 1280950.HJO_15079 1.1e-35 156.4 Bacteria Bacteria COG1846@1,COG1846@2 NA|NA|NA K DNA-binding transcription factor activity HIMHAPGP_01596 1168065.DOK_12231 2.2e-44 185.7 Gammaproteobacteria ko:K01118 ko00000,ko01000 Bacteria 1NJP3@1224,1SA6R@1236,COG1182@1,COG1182@2 NA|NA|NA I Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity HIMHAPGP_01597 1280950.HJO_15074 2.9e-104 385.6 Hyphomonadaceae Bacteria 1MU6G@1224,2TR2W@28211,43X4S@69657,COG0318@1,COG0318@2 NA|NA|NA IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II HIMHAPGP_01598 59538.XP_005983100.1 3.8e-187 661.0 Opisthokonta GO:0008150,GO:0008152,GO:0009056,GO:0071704,GO:1901575 Opisthokonta 2QRDE@2759,38P80@33154,COG1228@1 NA|NA|NA G amidohydrolase HIMHAPGP_01599 1349767.GJA_2047 2e-71 276.2 Oxalobacteraceae besA ko:K07017 ko00000 Bacteria 1RB1X@1224,2VYUM@28216,4763T@75682,COG2819@1,COG2819@2 NA|NA|NA S Putative esterase HIMHAPGP_01600 1219035.NT2_01_04860 4.8e-131 474.2 Sphingomonadales uvrB GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009314,GO:0009380,GO:0009628,GO:0032991,GO:0042802,GO:0044424,GO:0044464,GO:0050896,GO:1902494,GO:1905347,GO:1905348,GO:1990391 ko:K03702,ko:K08999 ko03420,map03420 ko00000,ko00001,ko03400 Bacteria 1MUFK@1224,2K0F9@204457,2TQSP@28211,COG0556@1,COG0556@2 NA|NA|NA L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage HIMHAPGP_01601 404589.Anae109_0460 9.2e-13 81.3 Bacteria ko:K20444 ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 Bacteria COG0845@1,COG0845@2 NA|NA|NA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family HIMHAPGP_01602 745310.G432_12770 8.4e-170 603.2 Sphingomonadales acdA 1.3.8.1,1.3.8.7 ko:K00248,ko:K00249 ko00071,ko00280,ko00410,ko00640,ko00650,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map00650,map01100,map01110,map01120,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01178,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00120,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUDR@1224,2JZVG@204457,2TQKE@28211,COG1960@1,COG1960@2 NA|NA|NA I acyl-CoA dehydrogenase HIMHAPGP_01603 1105367.CG50_13260 4.5e-11 72.8 Alphaproteobacteria rpmH GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02914 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1NGGS@1224,2UJCE@28211,COG0230@1,COG0230@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL34 family HIMHAPGP_01605 1248916.ANFY01000003_gene960 3.8e-182 644.8 Sphingomonadales yidC GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0031224,GO:0031226,GO:0032940,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051205,GO:0051234,GO:0051259,GO:0051260,GO:0051641,GO:0061024,GO:0065003,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150 ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 Bacteria 1MV5M@1224,2K1E1@204457,2TSTJ@28211,COG0706@1,COG0706@2 NA|NA|NA U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins HIMHAPGP_01606 1248916.ANFY01000003_gene961 6.2e-71 273.9 Sphingomonadales engB GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:0097367,GO:1901265,GO:1901363 ko:K03978 ko00000,ko03036 Bacteria 1MY3Z@1224,2K0SN@204457,2U5E5@28211,COG0218@1,COG0218@2 NA|NA|NA D Necessary for normal cell division and for the maintenance of normal septation HIMHAPGP_01607 1248916.ANFY01000003_gene560 1.2e-205 722.6 Sphingomonadales 1.13.12.16 ko:K00459 ko00910,map00910 R00025 RC02541,RC02759 ko00000,ko00001,ko01000 Bacteria 1N52W@1224,2K00A@204457,2TV8B@28211,COG2070@1,COG2070@2 NA|NA|NA S 2-nitropropane dioxygenase HIMHAPGP_01608 1502851.FG93_05437 7.3e-68 263.8 Bradyrhizobiaceae ung2 3.2.2.27 ko:K21929 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 1R9XV@1224,2TSWU@28211,3K33M@41294,COG1573@1,COG1573@2 NA|NA|NA L UreE urease accessory protein, C-terminal domain HIMHAPGP_01609 95619.PM1_0213140 2.6e-57 228.4 Proteobacteria Bacteria 1RDGV@1224,COG5483@1,COG5483@2 NA|NA|NA L Protein of unknown function, DUF488 HIMHAPGP_01610 1192868.CAIU01000019_gene2706 1.1e-41 176.0 Phyllobacteriaceae yeaO Bacteria 1MZ7H@1224,2UCUJ@28211,43KP6@69277,COG3189@1,COG3189@2 NA|NA|NA S Protein of unknown function, DUF488 HIMHAPGP_01611 1234595.C725_2116 1.4e-27 130.2 Alphaproteobacteria bioC 2.1.1.197 ko:K02169 ko00780,ko01100,map00780,map01100 M00572 R09543 RC00003,RC00460 ko00000,ko00001,ko00002,ko01000 Bacteria 1PA5F@1224,2TRFS@28211,COG0500@1,COG2226@2 NA|NA|NA Q COG0500 SAM-dependent methyltransferases HIMHAPGP_01612 1121033.AUCF01000003_gene3197 2.2e-44 186.0 Rhodospirillales comF 3.6.4.12 ko:K03654 ko03018,map03018 ko00000,ko00001,ko01000,ko03400 Bacteria 1RHAV@1224,2JSB6@204441,2TV7G@28211,COG1040@1,COG1040@2 NA|NA|NA S Phosphoribosyl transferase domain HIMHAPGP_01613 745310.G432_18295 1.3e-30 138.7 Sphingomonadales grxC GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0033218,GO:0042277,GO:0043167,GO:0043168,GO:0043295,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0055114,GO:0072341,GO:1900750,GO:1901681 ko:K03676 ko00000,ko03110 iAPECO1_1312.grxC Bacteria 1N72P@1224,2K5VT@204457,2UFM1@28211,COG0695@1,COG0695@2 NA|NA|NA O Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins HIMHAPGP_01614 1234595.C725_2113 2e-72 279.3 unclassified Alphaproteobacteria ramA 3.5.5.1 ko:K01501,ko:K11206 ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00380,map00460,map00627,map00643,map00910,map01120 R00540,R01887,R03093,R03542,R05591,R07855 RC00315,RC00325,RC00617,RC00959,RC02811 ko00000,ko00001,ko01000 Bacteria 1MUUB@1224,2TRGZ@28211,4BQ0S@82117,COG0388@1,COG0388@2 NA|NA|NA S Carbon-nitrogen hydrolase HIMHAPGP_01615 1248916.ANFY01000010_gene381 5e-27 127.5 Sphingomonadales Bacteria 1MZN2@1224,2K54Q@204457,2UBTA@28211,COG5319@1,COG5319@2 NA|NA|NA S protein conserved in bacteria HIMHAPGP_01617 1248916.ANFY01000002_gene1325 9.3e-32 144.8 Alphaproteobacteria Bacteria 1N2QY@1224,2AKVH@1,2UMEG@28211,31BNP@2 NA|NA|NA HIMHAPGP_01618 1248916.ANFY01000002_gene1326 3.9e-121 441.8 Sphingomonadales 2.4.1.336 ko:K02359,ko:K11740,ko:K19003 ko00561,ko01100,ko04320,map00561,map01100,map04320 R02689 RC00005,RC00059 ko00000,ko00001,ko01000,ko01003 GT2 Bacteria 1P7GR@1224,2K0A7@204457,2TS4P@28211,COG1215@1,COG1215@2 NA|NA|NA M COG1215 Glycosyltransferases, probably involved in cell wall biogenesis HIMHAPGP_01619 1248916.ANFY01000002_gene1328 1.3e-125 456.1 Sphingomonadales thyA 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUBD@1224,2K0PF@204457,2TQSB@28211,COG0207@1,COG0207@2 NA|NA|NA F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis HIMHAPGP_01620 1122970.AUHC01000009_gene286 2.9e-159 568.2 Sphingomonadales fabH 2.3.1.180,2.3.1.207 ko:K00648,ko:K16872 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 iIT341.HP0202 Bacteria 1MU9N@1224,2K2VX@204457,2TU94@28211,COG0332@1,COG0332@2 NA|NA|NA I COG0332 3-oxoacyl- acyl-carrier-protein synthase III HIMHAPGP_01622 1037409.BJ6T_82230 8.9e-18 97.4 Bradyrhizobiaceae yjeP GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K05802,ko:K22051 ko00000,ko02000 1.A.23.1.1,1.A.23.1.2,1.A.23.1.3 Bacteria 1N4GX@1224,2U431@28211,3JXYX@41294,COG3064@1,COG3064@2 NA|NA|NA M Membrane HIMHAPGP_01623 745310.G432_09755 1.3e-98 366.3 Sphingomonadales Bacteria 1MW05@1224,2K0U5@204457,2TS7R@28211,COG2939@1,COG2939@2 NA|NA|NA E peptidase S10 serine carboxypeptidase HIMHAPGP_01624 1161401.ASJA01000005_gene2430 4.4e-82 311.6 Hyphomonadaceae iaaA 3.4.19.5,3.5.1.1 ko:K01424,ko:K13051 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 R00485 RC00010,RC02798 ko00000,ko00001,ko01000,ko01002 Bacteria 1MWFC@1224,2TU8K@28211,43WRE@69657,COG1446@1,COG1446@2,COG4242@1,COG4242@2 NA|NA|NA E asparaginase HIMHAPGP_01625 158500.BV97_05447 0.0 1203.7 Sphingomonadales Bacteria 1MU9K@1224,2KEFT@204457,2TWY3@28211,COG1629@1,COG1629@2,COG4771@2 NA|NA|NA P Outer membrane protein beta-barrel family HIMHAPGP_01626 75379.Tint_0563 3.8e-71 275.8 unclassified Burkholderiales glpK GO:0003674,GO:0003824,GO:0004370,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019405,GO:0019563,GO:0019751,GO:0033554,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046164,GO:0046174,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:1901575,GO:1901615,GO:1901616 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 iE2348C_1286.E2348C_4230,iECNA114_1301.ECNA114_4065,iECSF_1327.ECSF_3786 Bacteria 1KITK@119065,1MUP7@1224,2VICH@28216,COG0554@1,COG0554@2 NA|NA|NA F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate HIMHAPGP_01627 876044.IMCC3088_1489 8.2e-159 567.0 Gammaproteobacteria ygcU 2.5.1.26 ko:K00803,ko:K11472 ko00565,ko00630,ko01100,ko01110,ko01120,ko01130,ko04146,map00565,map00630,map01100,map01110,map01120,map01130,map04146 R00475,R04311 RC00020,RC00042,RC02886 ko00000,ko00001,ko01000 Bacteria 1MXTV@1224,1RRN8@1236,COG0277@1,COG0277@2 NA|NA|NA C COG0277 FAD FMN-containing dehydrogenases HIMHAPGP_01628 876044.IMCC3088_1490 2.4e-127 462.6 Gammaproteobacteria glpD 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 R00848 RC00029 ko00000,ko00001,ko01000 Bacteria 1MUMY@1224,1RMGP@1236,COG0578@1,COG0578@2 NA|NA|NA C Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family HIMHAPGP_01630 228405.HNE_1451 3.9e-191 674.5 Alphaproteobacteria Bacteria 1MURY@1224,2U3J5@28211,COG1053@1,COG1053@2 NA|NA|NA C FAD binding domain HIMHAPGP_01631 228405.HNE_1452 3e-58 232.3 Alphaproteobacteria Bacteria 1P2I1@1224,2UIDG@28211,COG0583@1,COG0583@2 NA|NA|NA K LysR substrate binding domain HIMHAPGP_01632 323097.Nham_0648 4.8e-105 387.9 Bradyrhizobiaceae ko:K07234 ko00000 Bacteria 1MUJK@1224,2TSQ2@28211,3JUG3@41294,COG3213@1,COG3213@2 NA|NA|NA P NnrS protein HIMHAPGP_01633 1030157.AFMP01000040_gene1573 2e-213 748.8 Sphingomonadales 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 Bacteria 1MU4D@1224,2K12J@204457,2TSSI@28211,COG1022@1,COG1022@2 NA|NA|NA I synthetase HIMHAPGP_01634 1248916.ANFY01000003_gene518 9.6e-152 543.9 Sphingomonadales ggt 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 Bacteria 1MUV6@1224,2K0PZ@204457,2TR49@28211,COG0405@1,COG0405@2 NA|NA|NA E gamma-glutamyltranspeptidase HIMHAPGP_01635 414684.RC1_2863 5.4e-18 96.7 Rhodospirillales pyrD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.3.1.14,1.3.5.2 ko:K00254,ko:K02823,ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01868,R01869 RC00051 ko00000,ko00001,ko00002,ko01000 Bacteria 1MU7C@1224,2JPD2@204441,2TRF8@28211,COG0167@1,COG0167@2 NA|NA|NA F Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor HIMHAPGP_01636 1123267.JONN01000001_gene794 8.1e-92 343.6 Sphingomonadales nusA GO:0001000,GO:0001121,GO:0001125,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 ko:K02600 ko00000,ko03009,ko03021 Bacteria 1MWT7@1224,2K1KF@204457,2TRQN@28211,COG0195@1,COG0195@2 NA|NA|NA K Participates in both transcription termination and antitermination HIMHAPGP_01637 1030157.AFMP01000040_gene1492 3.6e-54 218.4 Sphingomonadales ylxR ko:K02600,ko:K07742 ko00000,ko03009,ko03021 Bacteria 1RHPR@1224,2K2B7@204457,2U9RY@28211,COG2740@1,COG2740@2 NA|NA|NA K Nucleic-acid-binding protein HIMHAPGP_01638 745310.G432_07635 2.7e-249 868.6 Sphingomonadales infB GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034645,GO:0036094,GO:0043021,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02519 ko00000,ko03012,ko03029 Bacteria 1MV26@1224,2K1X7@204457,2TQMY@28211,COG0532@1,COG0532@2 NA|NA|NA J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex HIMHAPGP_01639 1234595.C725_1820 1e-32 146.4 unclassified Alphaproteobacteria rbfA ko:K02834 ko00000,ko03009 Bacteria 1MZPE@1224,2UCJF@28211,4BQXN@82117,COG0858@1,COG0858@2 NA|NA|NA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA HIMHAPGP_01640 1144307.PMI04_00375 2.2e-13 82.0 Sphingomonadales Bacteria 1NIHT@1224,2EQ70@1,2K5XI@204457,2UK3J@28211,33HT9@2 NA|NA|NA HIMHAPGP_01641 1248916.ANFY01000003_gene996 1.5e-99 369.4 Sphingomonadales hbdA 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 Bacteria 1MU9P@1224,2K0X2@204457,2TR8E@28211,COG1250@1,COG1250@2 NA|NA|NA I Dehydrogenase HIMHAPGP_01642 1248916.ANFY01000004_gene1693 1.2e-122 446.0 Sphingomonadales Bacteria 1MUBQ@1224,2K13W@204457,2TRPN@28211,COG1028@1,COG1028@2 NA|NA|NA IQ Belongs to the short-chain dehydrogenases reductases (SDR) family HIMHAPGP_01643 1123240.ATVO01000006_gene1486 6.4e-72 277.7 Sphingomonadales Bacteria 1MZXM@1224,2K256@204457,2TSZM@28211,COG0697@1,COG0697@2 NA|NA|NA EG of the drug metabolite transporter (DMT) superfamily HIMHAPGP_01644 745310.G432_07570 1.5e-32 145.2 Sphingomonadales purH 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1MUDQ@1224,2K0R5@204457,2TRMY@28211,COG0138@1,COG0138@2 NA|NA|NA F Bifunctional purine biosynthesis protein PurH HIMHAPGP_01645 1248916.ANFY01000017_gene1360 9.3e-188 662.9 Sphingomonadales sucC GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 Bacteria 1MVCE@1224,2K12N@204457,2TRXK@28211,COG0045@1,COG0045@2 NA|NA|NA C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit HIMHAPGP_01646 194867.ALBQ01000021_gene1960 6.4e-155 553.5 Sphingomonadales mdh GO:0003674,GO:0003824,GO:0004470,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019752,GO:0030060,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1360 Bacteria 1MV57@1224,2K17I@204457,2TSV6@28211,COG0039@1,COG0039@2 NA|NA|NA C Catalyzes the reversible oxidation of malate to oxaloacetate HIMHAPGP_01647 1187851.A33M_0248 5.7e-132 478.0 Rhodovulum vceB ko:K03446 M00701 ko00000,ko00002,ko02000 2.A.1.3 Bacteria 1RGPN@1224,2TQKW@28211,3FDPH@34008,COG0477@1,COG0477@2 NA|NA|NA U Major Facilitator Superfamily HIMHAPGP_01648 269796.Rru_A0156 9e-62 244.2 Rhodospirillales emrA ko:K03543 M00701 ko00000,ko00002,ko02000 8.A.1.1 Bacteria 1MU7I@1224,2JPQB@204441,2TS39@28211,COG1566@1,COG1566@2 NA|NA|NA V multidrug resistance efflux pump HIMHAPGP_01649 1219045.BV98_000259 7.7e-136 490.3 Sphingomonadales zapE GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0006091,GO:0006119,GO:0006123,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007005,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016310,GO:0017144,GO:0019538,GO:0019637,GO:0019646,GO:0019693,GO:0022900,GO:0022904,GO:0030163,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0035694,GO:0042773,GO:0042775,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071840,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901565,GO:1901575 3.6.4.7 ko:K06916,ko:K18798 ko00000,ko01000,ko03029,ko03036 Bacteria 1MUUW@1224,2K2A7@204457,2TRG1@28211,COG1485@1,COG1485@2 NA|NA|NA S AFG1 family ATPase HIMHAPGP_01650 1248916.ANFY01000017_gene1357 1.3e-33 149.4 Sphingomonadales Bacteria 1MZPH@1224,2K62E@204457,2UDIQ@28211,COG2050@1,COG2050@2 NA|NA|NA Q protein possibly involved in aromatic compounds catabolism HIMHAPGP_01651 1030157.AFMP01000052_gene128 2e-43 183.0 Bacteria ko:K07126 ko00000 Bacteria COG0790@1,COG0790@2 NA|NA|NA S beta-lactamase activity HIMHAPGP_01652 1123240.ATVO01000003_gene305 9.6e-125 453.0 Sphingomonadales sdhB 1.3.5.1,1.3.5.4 ko:K00240 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 Bacteria 1MVHS@1224,2K0CN@204457,2TQYF@28211,COG0479@1,COG0479@2 NA|NA|NA C Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family HIMHAPGP_01653 627192.SLG_11950 6.1e-113 413.7 Sphingomonadales sdhA GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 Bacteria 1MU5M@1224,2K1NE@204457,2TQJA@28211,COG1053@1,COG1053@2 NA|NA|NA C Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily HIMHAPGP_01654 266748.HY04_13010 1.4e-13 82.8 Chryseobacterium wbiB 5.1.3.25 ko:K17947 ko00523,ko01130,map00523,map01130 R10279 RC00289 ko00000,ko00001,ko01000 Bacteria 1IGEN@117743,3ZRI0@59732,4NIBV@976,COG0451@1,COG0451@2 NA|NA|NA M Male sterility protein HIMHAPGP_01655 742767.HMPREF9456_02668 5.8e-38 164.5 Bacteroidia Bacteria 2G32E@200643,4NNQ5@976,COG0110@1,COG0110@2 NA|NA|NA S Bacterial transferase hexapeptide HIMHAPGP_01656 742767.HMPREF9456_02663 1.1e-69 270.4 Bacteroidia ko:K06320 ko00000 Bacteria 2FVWT@200643,4PH5K@976,COG4641@1,COG4641@2 NA|NA|NA S Protein conserved in bacteria HIMHAPGP_01657 742767.HMPREF9456_02662 1.6e-44 186.8 Porphyromonadaceae ko:K06320 ko00000 Bacteria 2313U@171551,2G1RC@200643,4PH5J@976,COG4641@1,COG4641@2 NA|NA|NA S Protein conserved in bacteria HIMHAPGP_01658 1120960.ATXG01000011_gene3589 9.1e-17 94.4 Actinobacteria Bacteria 28K33@1,2I4X8@201174,2Z9SC@2 NA|NA|NA HIMHAPGP_01659 1184609.KILIM_001_00340 7.1e-07 61.6 Bacteria Bacteria COG0673@1,COG0673@2 NA|NA|NA S inositol 2-dehydrogenase activity HIMHAPGP_01660 367336.OM2255_08836 2.1e-17 96.7 Alphaproteobacteria wzz Bacteria 1MXGW@1224,2UW73@28211,COG3765@1,COG3765@2 NA|NA|NA M Chain length determinant protein HIMHAPGP_01661 517722.AEUE01000002_gene2013 1.4e-144 519.2 Sphingomonadales pseB 4.2.1.115 ko:K13006,ko:K15673,ko:K15894 ko00520,ko01051,ko01052,map00520,map01051,map01052 R09697 RC02609 ko00000,ko00001,ko01000,ko01005,ko01008 Bacteria 1MWKY@1224,2K0BA@204457,2TT4K@28211,COG1086@1,COG1086@2 NA|NA|NA GM Polysaccharide biosynthesis protein HIMHAPGP_01662 1123229.AUBC01000004_gene3022 3.5e-147 528.1 Bradyrhizobiaceae pseC 2.6.1.102 ko:K13010 ko00520,map00520 R10460 RC00006,RC00781 ko00000,ko00001,ko01000,ko01005,ko01007 Bacteria 1MUPN@1224,2TRIQ@28211,3JSRK@41294,COG0399@1,COG0399@2 NA|NA|NA E Belongs to the DegT DnrJ EryC1 family HIMHAPGP_01663 517722.AEUE01000002_gene2015 3.7e-83 314.7 Sphingomonadales pseF GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.7.43,2.7.7.81,2.7.7.82 ko:K00983,ko:K15899,ko:K18431 ko00520,ko01100,map00520,map01100 R01117,R04215,R09843,R10182 RC00152 ko00000,ko00001,ko01000 Bacteria 1QACI@1224,2KCNG@204457,2U5PV@28211,COG1083@1,COG1083@2 NA|NA|NA M Cytidylyltransferase HIMHAPGP_01664 472759.Nhal_0398 5.5e-89 335.1 Chromatiales pseG Bacteria 1Q330@1224,1RYTC@1236,1WYUY@135613,COG1670@1,COG1670@2,COG3980@1,COG3980@2 NA|NA|NA M Glycosyltransferase family 28 C-terminal domain HIMHAPGP_01665 391038.Bphy_3008 1.8e-145 522.3 Burkholderiaceae pseI 2.5.1.56,2.5.1.97 ko:K01654,ko:K15898 ko00520,ko01100,map00520,map01100 R01804,R04435,R09841 RC00159 ko00000,ko00001,ko01000 Bacteria 1K8JV@119060,1MWG3@1224,2VHMH@28216,COG2089@1,COG2089@2 NA|NA|NA M NeuB family HIMHAPGP_01666 1123229.AUBC01000004_gene3013 5.4e-80 304.7 Alphaproteobacteria afr 1.1.1.292 ko:K19181 ko00000,ko01000 Bacteria 1Q8R1@1224,2U8HN@28211,COG0673@1,COG0673@2 NA|NA|NA S Oxidoreductase family, NAD-binding Rossmann fold HIMHAPGP_01667 517722.AEUE01000002_gene2020 5.1e-155 554.3 Sphingomonadales Bacteria 1MUPN@1224,2K340@204457,2TQVS@28211,COG0399@1,COG0399@2 NA|NA|NA E Belongs to the DegT DnrJ EryC1 family HIMHAPGP_01668 517722.AEUE01000002_gene2021 2e-49 202.2 Alphaproteobacteria Bacteria 1N9TX@1224,2USFR@28211,COG1670@1,COG1670@2 NA|NA|NA J Acetyltransferase (GNAT) domain HIMHAPGP_01669 517722.AEUE01000002_gene2022 2.6e-65 255.8 Alphaproteobacteria Bacteria 1RK22@1224,2UR8Z@28211,COG0859@1,COG0859@2 NA|NA|NA M PFAM glycosyl transferase family 9 HIMHAPGP_01670 1123229.AUBC01000004_gene3017 7.5e-171 606.7 Bradyrhizobiaceae tilS 6.3.4.19 ko:K04075 R09597 RC02633,RC02634 ko00000,ko01000,ko03016 Bacteria 1MVXT@1224,2U8J4@28211,3K5WN@41294,COG0037@1,COG0037@2 NA|NA|NA D tRNA processing HIMHAPGP_01671 1123229.AUBC01000004_gene3018 2.4e-46 192.2 Bradyrhizobiaceae hisH ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 Bacteria 1MU4X@1224,2TTT4@28211,3JSP5@41294,COG0118@1,COG0118@2 NA|NA|NA E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR HIMHAPGP_01672 1123229.AUBC01000004_gene3019 1.4e-64 253.1 Bacteria Bacteria COG0107@1,COG0107@2 NA|NA|NA E imidazoleglycerol-phosphate synthase activity HIMHAPGP_01673 1123229.AUBC01000004_gene3020 3.6e-166 591.3 Bradyrhizobiaceae tilS 6.3.4.19 ko:K04075 R09597 RC02633,RC02634 ko00000,ko01000,ko03016 Bacteria 1NKHX@1224,2U48T@28211,3JZT5@41294,COG0037@1,COG0037@2 NA|NA|NA D ATPase of the PP-loop superfamily implicated in cell cycle control HIMHAPGP_01674 1123229.AUBC01000004_gene3011 1.3e-65 256.9 Alphaproteobacteria 1.1.1.1 ko:K00001 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 Bacteria 1NYF5@1224,2UTGH@28211,COG1063@1,COG1063@2 NA|NA|NA E Zinc-binding dehydrogenase HIMHAPGP_01675 517722.AEUE01000002_gene2025 4.2e-70 271.9 Bacteria Bacteria COG0673@1,COG0673@2 NA|NA|NA S inositol 2-dehydrogenase activity HIMHAPGP_01676 517722.AEUE01000002_gene2026 1.7e-137 496.1 Bacteria ko:K07265 ko00000 Bacteria COG3562@1,COG3562@2 NA|NA|NA M capsule polysaccharide HIMHAPGP_01677 85643.Tmz1t_0746 1.9e-60 240.0 Proteobacteria Bacteria 1N629@1224,2ENEB@1,33G1U@2 NA|NA|NA HIMHAPGP_01678 392499.Swit_2311 4.2e-149 534.3 Sphingomonadales Bacteria 1MVVU@1224,2K8YH@204457,2UQVB@28211,COG0346@1,COG0346@2 NA|NA|NA E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily HIMHAPGP_01679 1192034.CAP_2992 5.2e-64 251.1 Proteobacteria dltE ko:K14189 ko00000,ko01000 Bacteria 1QSYJ@1224,COG3967@1,COG3967@2 NA|NA|NA M Belongs to the short-chain dehydrogenases reductases (SDR) family HIMHAPGP_01680 1088721.NSU_3382 0.0 1260.4 Sphingomonadales MA20_17010 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1MV21@1224,2K18V@204457,2TSZ9@28211,COG2609@1,COG2609@2 NA|NA|NA C Transketolase, thiamine diphosphate binding domain HIMHAPGP_01681 392499.Swit_2303 6.9e-155 553.5 Sphingomonadales Bacteria 1MVQM@1224,2K5IS@204457,2U3TF@28211,COG3386@1,COG3386@2 NA|NA|NA G SMP-30/Gluconolaconase/LRE-like region HIMHAPGP_01682 392499.Swit_2304 8.4e-41 172.9 Sphingomonadales Bacteria 1MZTP@1224,2K1JC@204457,2TQKN@28211,COG3246@1,COG3246@2 NA|NA|NA S beta-keto acid cleavage enzyme HIMHAPGP_01685 69279.BG36_12955 9.1e-202 709.5 Phyllobacteriaceae narK ko:K02575 ko00910,map00910 M00615 ko00000,ko00001,ko00002,ko02000 2.A.1.8 Bacteria 1MU27@1224,2TSXZ@28211,43JEX@69277,COG2223@1,COG2223@2 NA|NA|NA P transporter HIMHAPGP_01686 1335760.ASTG01000002_gene2259 7.7e-36 156.4 Sphingomonadales grxD ko:K07390 ko00000,ko03029,ko03110 Bacteria 1MZ4V@1224,2K55Y@204457,2U9QB@28211,COG0278@1,COG0278@2 NA|NA|NA O Belongs to the glutaredoxin family. Monothiol subfamily HIMHAPGP_01687 1044.EH31_13380 4.5e-22 110.2 Sphingomonadales colA Bacteria 1R3MM@1224,2K5YQ@204457,2UBUW@28211,COG0271@1,COG0271@2 NA|NA|NA T Belongs to the BolA IbaG family HIMHAPGP_01688 1174684.EBMC1_00880 5.9e-28 130.2 Sphingomonadales MA20_09035 Bacteria 1MZRN@1224,2K533@204457,2UC1G@28211,COG5467@1,COG5467@2 NA|NA|NA S Domain of unknown function (DUF1476) HIMHAPGP_01689 1030157.AFMP01000040_gene1459 3.7e-13 80.1 Proteobacteria ko:K09946 ko00000 Bacteria 1NJJ3@1224,COG3422@1,COG3422@2 NA|NA|NA S Domain of unknown function (DUF1508) HIMHAPGP_01690 745310.G432_02655 9.2e-31 140.2 Sphingomonadales MA20_42435 Bacteria 1N82D@1224,2K4U1@204457,2UFA9@28211,COG5389@1,COG5389@2 NA|NA|NA S Protein of unknown function (DUF721) HIMHAPGP_01691 1248760.ANFZ01000006_gene2578 1.2e-85 323.6 Sphingomonadales mutY GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 ko:K03575 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 1MUD4@1224,2K0ZZ@204457,2TQVX@28211,COG1194@1,COG1194@2 NA|NA|NA L glycosylase HIMHAPGP_01692 1248916.ANFY01000003_gene1047 5.1e-82 311.2 Sphingomonadales nudC 3.6.1.22 ko:K03426 ko00760,ko01100,ko04146,map00760,map01100,map04146 R00103,R03004,R11104 RC00002 ko00000,ko00001,ko01000 Bacteria 1QGCX@1224,2K1ZX@204457,2TVMG@28211,COG2816@1,COG2816@2 NA|NA|NA L Belongs to the Nudix hydrolase family HIMHAPGP_01693 1123240.ATVO01000005_gene1902 3.4e-160 572.4 Sphingomonadales Bacteria 1MU2C@1224,2K07A@204457,2TQS3@28211,COG5001@1,COG5001@2 NA|NA|NA T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain HIMHAPGP_01694 1248916.ANFY01000005_gene2818 1.7e-93 349.4 Sphingomonadales pheA GO:0003674,GO:0003824,GO:0004106,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 2.5.1.54,4.2.1.51,5.4.99.5 ko:K03856,ko:K04518,ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022,M00024,M00025 R00691,R01373,R01715,R01826 RC00360,RC00435,RC03116 ko00000,ko00001,ko00002,ko01000 iECNA114_1301.ECNA114_2667 Bacteria 1MU60@1224,2K0AM@204457,2TSUT@28211,COG0077@1,COG0077@2 NA|NA|NA E Prephenate dehydratase HIMHAPGP_01695 1123240.ATVO01000007_gene2296 6e-56 224.2 Sphingomonadales cycM ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 Bacteria 1RIDN@1224,2K42S@204457,2U142@28211,COG3474@1,COG3474@2 NA|NA|NA C cytochrome C HIMHAPGP_01696 392499.Swit_2313 1.4e-128 466.1 Sphingomonadales 4.1.1.45 ko:K03392,ko:K15062 ko00380,ko00627,ko01100,ko01120,map00380,map00627,map01100,map01120 M00038 R04323,R09277 RC00757,RC00779,RC02478 ko00000,ko00001,ko00002,ko01000 Bacteria 1R5PG@1224,2K1BU@204457,2U2G9@28211,COG2159@1,COG2159@2,COG4538@1,COG4538@2 NA|NA|NA S PFAM amidohydrolase 2 HIMHAPGP_01697 392499.Swit_4276 9.3e-82 310.5 Sphingomonadales Bacteria 1N663@1224,2K8F0@204457,2TRAK@28211,COG0583@1,COG0583@2 NA|NA|NA K Bacterial regulatory helix-turn-helix protein, lysR family HIMHAPGP_01698 392499.Swit_2314 5.2e-103 380.9 Sphingomonadales Bacteria 1N0MX@1224,2K6FX@204457,2UEB5@28211,COG0702@1,COG0702@2 NA|NA|NA GM NmrA-like family HIMHAPGP_01699 392499.Swit_2302 3.5e-106 391.7 Sphingomonadales Bacteria 1R8E0@1224,2K1MJ@204457,2U3K3@28211,COG0179@1,COG0179@2 NA|NA|NA Q Fumarylacetoacetate (FAA) hydrolase family HIMHAPGP_01700 392499.Swit_2308 1.5e-131 476.1 Sphingomonadales 4.1.1.45 ko:K03392,ko:K15062 ko00380,ko00627,ko01100,ko01120,map00380,map00627,map01100,map01120 M00038 R04323,R09277 RC00757,RC00779,RC02478 ko00000,ko00001,ko00002,ko01000 Bacteria 1R5PG@1224,2K1BU@204457,2U2G9@28211,COG2159@1,COG2159@2 NA|NA|NA S PFAM amidohydrolase 2 HIMHAPGP_01701 392499.Swit_2301 4.8e-270 937.2 Sphingomonadales ko:K02014 ko00000,ko02000 1.B.14 Bacteria 1QTXJ@1224,2KEBD@204457,2U2G4@28211,COG4773@1,COG4773@2 NA|NA|NA P PFAM TonB-dependent Receptor HIMHAPGP_01702 13689.BV96_02126 3.8e-98 365.2 Sphingomonadales yetM Bacteria 1MWWT@1224,2KCVT@204457,2TRZP@28211,COG0654@1,COG0654@2 NA|NA|NA C FAD binding domain HIMHAPGP_01703 392499.Swit_3412 4e-140 504.6 Sphingomonadales Bacteria 1QURS@1224,2KEAZ@204457,2TW50@28211,COG1506@1,COG1506@2 NA|NA|NA E BAAT / Acyl-CoA thioester hydrolase C terminal HIMHAPGP_01704 392499.Swit_3896 7.1e-121 440.7 Sphingomonadales proB GO:0003674,GO:0003824,GO:0004349,GO:0004350,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016491,GO:0016620,GO:0016740,GO:0016772,GO:0016774,GO:0016903,GO:0018130,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_3198 Bacteria 1MUBG@1224,2K0DF@204457,2TRKB@28211,COG0263@1,COG0263@2 NA|NA|NA E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate HIMHAPGP_01705 1174684.EBMC1_07230 6e-48 197.2 Sphingomonadales obg GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0007059,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0022607,GO:0022611,GO:0022613,GO:0022618,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0042254,GO:0042255,GO:0043021,GO:0043023,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0065003,GO:0065007,GO:0070925,GO:0071826,GO:0071840,GO:0090069,GO:0090071,GO:0097159,GO:0097367,GO:1901265,GO:1901363 ko:K03979 ko00000,ko01000,ko03009 Bacteria 1MUGZ@1224,2K1GJ@204457,2TR5I@28211,COG0536@1,COG0536@2 NA|NA|NA S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HIMHAPGP_01706 1081640.AGFU01000011_gene1241 1.5e-105 389.8 Sphingomonadales ybdL GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0008144,GO:0008483,GO:0010326,GO:0016740,GO:0016769,GO:0019842,GO:0030170,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0071944,GO:0097159,GO:1901363 2.6.1.17,2.6.1.88 ko:K14267,ko:K14287 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04475,R08618 RC00006,RC00025 ko00000,ko00001,ko00002,ko01000,ko01007 iNJ661.Rv0858c Bacteria 1MW0Z@1224,2K0KM@204457,2TTGJ@28211,COG0436@1,COG0436@2 NA|NA|NA E Aminotransferase HIMHAPGP_01707 685778.AORL01000022_gene1533 1.8e-26 125.9 Sphingomonadales yceD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 ko:K07040 ko00000 Bacteria 1N7C2@1224,2K4K6@204457,2UC4J@28211,COG1399@1,COG1399@2 NA|NA|NA S Uncharacterized ACR, COG1399 HIMHAPGP_01708 745310.G432_11175 3.8e-37 161.4 Sphingomonadales ko:K17662 ko00000,ko03029 Bacteria 1N12T@1224,2K5B4@204457,2UCES@28211,COG5452@1,COG5452@2 NA|NA|NA S Ubiquinol-cytochrome C chaperone HIMHAPGP_01709 1120705.FG95_02585 3.7e-39 167.9 Sphingomonadales MA20_36760 Bacteria 1RHYM@1224,2K4H5@204457,2UBU9@28211,COG2913@1,COG2913@2 NA|NA|NA J Small protein A (tmRNA-binding) HIMHAPGP_01710 84531.JMTZ01000006_gene3528 2.6e-45 188.0 Xanthomonadales hppA 3.6.1.1 ko:K15987 ko00190,map00190 ko00000,ko00001,ko01000 3.A.10.1 Bacteria 1MUQ3@1224,1RN4K@1236,1X3IX@135614,COG2885@1,COG2885@2,COG3808@1,COG3808@2 NA|NA|NA C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force HIMHAPGP_01711 745277.GRAQ_04071 8.5e-143 513.8 Rahnella 3.1.1.1 ko:K03928 ko00000,ko01000 Bacteria 1QTZP@1224,1RPB9@1236,3FFGI@34037,COG2267@1,COG2267@2 NA|NA|NA I Alpha/beta hydrolase family HIMHAPGP_01712 1174684.EBMC1_06559 4e-57 228.0 Sphingomonadales MA20_14935 Bacteria 1RE97@1224,2K3XR@204457,2U8N9@28211,COG1309@1,COG1309@2 NA|NA|NA K Transcriptional regulator HIMHAPGP_01713 1550073.JROH01000026_gene985 1.9e-46 191.8 Sphingomonadales ko:K07107 ko00000,ko01000 Bacteria 1RHB1@1224,2K4SF@204457,2UATC@28211,COG0824@1,COG0824@2 NA|NA|NA S thioesterase HIMHAPGP_01714 1123240.ATVO01000006_gene1348 1.8e-84 319.3 Sphingomonadales dat GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016769,GO:0019478,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0046416,GO:0046437,GO:0047810,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.6.1.21 ko:K00824 ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100 R01148,R01582,R02459,R02851,R02924,R05053 RC00006,RC00008,RC00025 ko00000,ko00001,ko01000,ko01007 Bacteria 1MVAT@1224,2K47Y@204457,2TR7R@28211,COG0115@1,COG0115@2 NA|NA|NA EH D-amino acid aminotransferase HIMHAPGP_01715 1123360.thalar_02890 3.6e-51 207.6 Bacteria ko:K07216 ko00000 Bacteria COG2703@1,COG2703@2 NA|NA|NA P oxygen carrier activity HIMHAPGP_01716 1123360.thalar_02889 3.7e-48 198.0 Alphaproteobacteria Bacteria 1MYWT@1224,2CB7M@1,2UVJC@28211,31H4T@2 NA|NA|NA HIMHAPGP_01717 1123360.thalar_02888 2e-222 778.5 Alphaproteobacteria 1.12.98.1 ko:K00441 ko00680,ko01100,ko01120,map00680,map01100,map01120 R03025 RC02628 ko00000,ko00001,ko01000 Bacteria 1QSPU@1224,2UQID@28211,COG1145@1,COG1145@2,COG1290@1,COG1290@2,COG1908@1,COG1908@2 NA|NA|NA C Methyl-viologen-reducing hydrogenase, delta subunit HIMHAPGP_01718 1123360.thalar_02887 1.7e-100 372.5 Bacteria sco ko:K07152 ko00000,ko03029 Bacteria COG1999@1,COG1999@2 NA|NA|NA M signal sequence binding HIMHAPGP_01719 1123360.thalar_02886 8.6e-98 363.6 Alphaproteobacteria ctaB GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 Bacteria 1MW3S@1224,2TRD8@28211,COG0109@1,COG0109@2 NA|NA|NA O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group HIMHAPGP_01720 1123360.thalar_02885 4.2e-162 577.4 Alphaproteobacteria cbaA 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 Bacteria 1R57U@1224,2U068@28211,COG0843@1,COG0843@2 NA|NA|NA C Cytochrome C and Quinol oxidase polypeptide I HIMHAPGP_01722 1112216.JH594425_gene2025 1.7e-147 529.3 Sphingomonadales fprA GO:0000166,GO:0003674,GO:0003824,GO:0004324,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0008152,GO:0008860,GO:0016020,GO:0016491,GO:0016730,GO:0016731,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0055114,GO:0070401,GO:0071944,GO:0097159,GO:1901265,GO:1901363 1.18.1.2,1.19.1.1 ko:K00528 R10159 ko00000,ko01000 Bacteria 1P58U@1224,2K06F@204457,2TUCG@28211,COG0493@1,COG0493@2 NA|NA|NA E COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases HIMHAPGP_01723 1123240.ATVO01000005_gene1810 7.8e-32 144.4 Sphingomonadales Bacteria 1N2Q4@1224,2K54U@204457,2UC5A@28211,COG1846@1,COG1846@2 NA|NA|NA K Transcriptional regulator HIMHAPGP_01724 1248916.ANFY01000011_gene1181 3.4e-76 292.4 Sphingomonadales ko:K10941 ko02020,ko02025,ko05111,map02020,map02025,map05111 ko00000,ko00001,ko03000 Bacteria 1MU0N@1224,2K2W6@204457,2TQPG@28211,COG2204@1,COG2204@2 NA|NA|NA K PFAM sigma-54 factor interaction domain-containing protein HIMHAPGP_01725 392499.Swit_3212 4.9e-211 740.3 Sphingomonadales gltA 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 iIT341.HP0026 Bacteria 1MUKX@1224,2K0JS@204457,2TS63@28211,COG0372@1,COG0372@2 NA|NA|NA C Belongs to the citrate synthase family HIMHAPGP_01726 745310.G432_02785 5.2e-177 627.5 Sphingomonadales gltX GO:0003674,GO:0003824,GO:0004812,GO:0004818,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006424,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.17,6.1.1.24 ko:K01885,ko:K09698 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R03651,R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 iEC042_1314.EC042_2616,iIT341.HP0476 Bacteria 1MUCR@1224,2K09A@204457,2TRSU@28211,COG0008@1,COG0008@2 NA|NA|NA J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) HIMHAPGP_01730 983920.Y88_0346 3.9e-42 178.3 Sphingomonadales cznB ko:K15727 ko00000,ko02000 8.A.1.2.1 Bacteria 1QMYR@1224,2K0FV@204457,2U69D@28211,COG0845@1,COG0845@2 NA|NA|NA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family HIMHAPGP_01731 1248916.ANFY01000007_gene2470 1.2e-25 123.2 Bacteria Bacteria COG5010@1,COG5010@2 NA|NA|NA HIMHAPGP_01732 1248916.ANFY01000007_gene2469 9.4e-22 110.2 Bacteria 3.4.23.43 ko:K02278 ko00000,ko01000,ko02035,ko02044 Bacteria COG4960@1,COG4960@2 NA|NA|NA OU Type IV leader peptidase family HIMHAPGP_01733 1346791.M529_02785 1e-106 392.9 Sphingomonadales Bacteria 1MV9V@1224,2C1VC@1,2K4V3@204457,2U2N5@28211,2Z83Q@2 NA|NA|NA HIMHAPGP_01735 1248916.ANFY01000007_gene2471 7.3e-10 72.0 Sphingomonadales Bacteria 1R2W2@1224,2KEVI@204457,2TZSM@28211,COG3063@1,COG3063@2 NA|NA|NA NU TPR repeat HIMHAPGP_01736 1248916.ANFY01000007_gene2472 3.7e-86 325.1 Sphingomonadales tadC ko:K12511 ko00000,ko02044 Bacteria 1MWAZ@1224,2K20F@204457,2VG2G@28211,COG2064@1,COG2064@2 NA|NA|NA NU Type II secretion system (T2SS), protein F HIMHAPGP_01737 1248916.ANFY01000007_gene2473 5.7e-82 311.2 Sphingomonadales ko:K12510 ko00000,ko02044 Bacteria 1MUXK@1224,2K2TT@204457,2VG2Q@28211,COG4965@1,COG4965@2 NA|NA|NA U Type II secretion system (T2SS), protein F HIMHAPGP_01738 1248916.ANFY01000007_gene2474 5.4e-179 634.0 Sphingomonadales cpaF ko:K02283 ko00000,ko02035,ko02044 Bacteria 1R7EN@1224,2K3GG@204457,2TRNT@28211,COG4962@1,COG4962@2 NA|NA|NA U Type II/IV secretion system protein HIMHAPGP_01739 1248916.ANFY01000007_gene2475 1.1e-74 287.3 Sphingomonadales cpaE1 ko:K02282 ko00000,ko02035,ko02044 Bacteria 1R9GH@1224,2K4AP@204457,2U3XM@28211,COG4963@1,COG4963@2 NA|NA|NA U Pilus assembly protein HIMHAPGP_01740 452662.SJA_C1-22520 1.8e-09 68.9 Sphingomonadales Bacteria 1P78B@1224,2B3CR@1,2K895@204457,2UYQU@28211,31W1G@2 NA|NA|NA HIMHAPGP_01741 1248916.ANFY01000007_gene2477 6.6e-121 441.0 Sphingomonadales cpaC ko:K02280 ko00000,ko02035,ko02044 Bacteria 1MV8G@1224,2K2YM@204457,2TRNN@28211,COG4964@1,COG4964@2 NA|NA|NA U Pilus formation protein N terminal region HIMHAPGP_01742 1248916.ANFY01000007_gene2478 9e-44 184.1 Sphingomonadales cpaB ko:K02279 ko00000,ko02035,ko02044 Bacteria 1MW75@1224,2K4PR@204457,2TTPE@28211,COG3745@1,COG3745@2 NA|NA|NA U Flp pilus assembly protein RcpC/CpaB HIMHAPGP_01746 426117.M446_5904 7e-16 90.5 Methylobacteriaceae Bacteria 1JXX1@119045,1PPJ4@1224,2V20V@28211,COG4961@1,COG4961@2 NA|NA|NA U PFAM TadE family protein HIMHAPGP_01748 1196324.A374_00005 3.9e-29 133.7 Bacilli ko:K07497 ko00000 Bacteria 1TQSP@1239,4HET5@91061,COG2801@1,COG2801@2,COG2963@1,COG2963@2 NA|NA|NA L COG2801 Transposase and inactivated derivatives HIMHAPGP_01749 856793.MICA_2213 6.9e-19 99.4 unclassified Alphaproteobacteria Bacteria 1R4UZ@1224,2U0XX@28211,4BRSM@82117,COG0582@1,COG0582@2 NA|NA|NA L Belongs to the 'phage' integrase family HIMHAPGP_01750 1007104.SUS17_2352 4.6e-240 837.4 Sphingomonadales 3.4.19.1 ko:K01303 ko00000,ko01000,ko01002 Bacteria 1MUJ3@1224,2K37J@204457,2TUZZ@28211,COG1506@1,COG1506@2 NA|NA|NA E X-Pro dipeptidyl-peptidase (S15 family) HIMHAPGP_01751 1522072.IL54_3106 1.4e-265 922.2 Sphingomonadales 3.4.24.71 ko:K01415,ko:K07386 ko00000,ko01000,ko01002,ko04147 Bacteria 1MVNQ@1224,2K02W@204457,2TRU4@28211,COG3590@1,COG3590@2 NA|NA|NA O peptidase M13 HIMHAPGP_01752 1234595.C725_2160 6.8e-36 156.8 Alphaproteobacteria ko:K07107 ko00000,ko01000 Bacteria 1N06V@1224,2UCAQ@28211,COG0824@1,COG0824@2 NA|NA|NA S thioesterase HIMHAPGP_01753 745310.G432_10595 5.1e-30 138.3 Sphingomonadales Bacteria 1MYZ1@1224,2K4IW@204457,2UCPV@28211,COG0457@1,COG0457@2 NA|NA|NA S Tetratricopeptide repeat HIMHAPGP_01754 1248916.ANFY01000003_gene1007 2.6e-63 248.8 Sphingomonadales MA20_24420 ko:K06889,ko:K07000 ko00000 Bacteria 1MX88@1224,2K1F6@204457,2TSRE@28211,COG1073@1,COG1073@2 NA|NA|NA S Alpha beta hydrolase HIMHAPGP_01755 1123240.ATVO01000006_gene1632 3.5e-175 621.7 Sphingomonadales recQ 3.6.4.12 ko:K03654 ko03018,map03018 ko00000,ko00001,ko01000,ko03400 Bacteria 1MVGG@1224,2K0QS@204457,2TS8B@28211,COG0514@1,COG0514@2 NA|NA|NA L DNA helicase HIMHAPGP_01756 1248916.ANFY01000007_gene2167 2e-229 802.0 Sphingomonadales cobT 3.4.17.14,6.6.1.2 ko:K07114,ko:K07260,ko:K09883 ko00550,ko00860,ko01100,ko01502,ko02020,map00550,map00860,map01100,map01502,map02020 M00651 R05227 RC02000 ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504,ko02000 1.A.13.2.2,1.A.13.2.3 Bacteria 1MX11@1224,2JZUK@204457,2TS4N@28211,COG4547@1,COG4547@2 NA|NA|NA H Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide 5, 6-dimethylbenzimidazole phosphoribosyltransferase) HIMHAPGP_01757 1169143.KB911035_gene2308 5e-285 986.9 Burkholderiaceae BDS1 Bacteria 1K5Q5@119060,1MU82@1224,2VJ5N@28216,COG2015@1,COG2015@2 NA|NA|NA Q Alkyl sulfatase dimerisation HIMHAPGP_01758 1123504.JQKD01000026_gene4280 1.3e-16 94.0 Comamonadaceae Bacteria 1P2I1@1224,2VTWR@28216,4AF4P@80864,COG0583@1,COG0583@2 NA|NA|NA K LysR substrate binding domain HIMHAPGP_01759 414684.RC1_2771 1.6e-226 792.7 Rhodospirillales acyII 3.5.1.11 ko:K01434 ko00311,ko01130,map00311,map01130 R02170 RC00166,RC00328 ko00000,ko00001,ko01000,ko01002 Bacteria 1MVMH@1224,2JPKU@204441,2TS4D@28211,COG2366@1,COG2366@2 NA|NA|NA S Penicillin amidase HIMHAPGP_01760 1123269.NX02_27930 1.5e-21 108.6 Sphingomonadales bolA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0019538,GO:0022603,GO:0022604,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051604,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097428,GO:0097659,GO:0106035,GO:1901360,GO:1901362,GO:1901564,GO:1901576 ko:K05527,ko:K22066 ko00000,ko03000,ko03029 Bacteria 1MZG5@1224,2K60E@204457,2UF6U@28211,COG0271@1,COG0271@2 NA|NA|NA T Belongs to the BolA IbaG family HIMHAPGP_01761 745310.G432_05700 4.7e-33 147.9 Sphingomonadales ko:K04562 ko00000,ko02035 Bacteria 1MXTG@1224,2K4VC@204457,2TRZH@28211,COG2214@1,COG2214@2 NA|NA|NA O molecular chaperone HIMHAPGP_01762 1537715.JQFJ01000002_gene2218 5.3e-151 540.8 Sphingomonadales 3.4.13.19 ko:K01273 ko00000,ko00537,ko01000,ko01002,ko04147 Bacteria 1MWEW@1224,2K0NN@204457,2TR5C@28211,COG2355@1,COG2355@2 NA|NA|NA E Membrane dipeptidase (Peptidase family M19) HIMHAPGP_01763 1537715.JQFJ01000002_gene1776 1.9e-86 326.2 Sphingomonadales lldD GO:0002218,GO:0002253,GO:0002376,GO:0002682,GO:0002684,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005886,GO:0006950,GO:0006952,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009605,GO:0009607,GO:0009617,GO:0009987,GO:0010204,GO:0016020,GO:0016999,GO:0017000,GO:0017144,GO:0023052,GO:0030312,GO:0031347,GO:0031349,GO:0042579,GO:0042742,GO:0042743,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044249,GO:0044424,GO:0044444,GO:0044464,GO:0045088,GO:0045089,GO:0048518,GO:0048583,GO:0048584,GO:0050665,GO:0050776,GO:0050778,GO:0050789,GO:0050794,GO:0050896,GO:0051186,GO:0051188,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0071944,GO:0072593,GO:0080134,GO:0098542,GO:1903409 1.1.2.3,1.1.3.15 ko:K00101,ko:K00104 ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130 R00196,R00475 RC00042,RC00044 ko00000,ko00001,ko01000 iNJ661.Rv1872c Bacteria 1MUEZ@1224,2K18M@204457,2TQNW@28211,COG1304@1,COG1304@2 NA|NA|NA C Dehydrogenase HIMHAPGP_01764 1219049.SP5_043_00100 1.1e-46 193.4 Sphingomonadales lolA Bacteria 1RA1S@1224,2K43J@204457,2U58W@28211,COG2834@1,COG2834@2 NA|NA|NA M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) HIMHAPGP_01765 745310.G432_01500 3.3e-63 248.4 Sphingomonadales gph 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 R01334 RC00017 ko00000,ko00001,ko01000 Bacteria 1RDDY@1224,2K1ZP@204457,2U79T@28211,COG0546@1,COG0546@2 NA|NA|NA S Phosphoglycolate phosphatase HIMHAPGP_01768 1151127.KB906328_gene2197 6.5e-46 190.3 Pseudomonas fluorescens group cysM 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUR6@1224,1RMS1@1236,1YN1Z@136843,COG0031@1,COG0031@2 NA|NA|NA E Cysteine synthase HIMHAPGP_01769 1535422.ND16A_2774 7.3e-133 481.5 Colwelliaceae Bacteria 1MWKN@1224,1RS91@1236,2Q802@267889,COG1629@1,COG4771@2 NA|NA|NA P TonB dependent receptor HIMHAPGP_01770 1220582.RRU01S_27_00420 3.8e-101 375.2 Rhizobiaceae patB 4.4.1.8 ko:K00842,ko:K14155 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 R00782,R01286,R02408,R04941 RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko01000,ko01007 Bacteria 1MY33@1224,2TR29@28211,4BDF2@82115,COG1168@1,COG1168@2 NA|NA|NA E Aminotransferase class I and II HIMHAPGP_01771 234267.Acid_3232 1.1e-10 72.8 Acidobacteria Bacteria 29WUM@1,30IG2@2,3Y90X@57723 NA|NA|NA S Putative mono-oxygenase ydhR HIMHAPGP_01772 1123269.NX02_24125 2.1e-228 798.1 Sphingomonadales aceA 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 Bacteria 1MWIF@1224,2K0CD@204457,2TU0Q@28211,COG2224@1,COG2224@2 NA|NA|NA C Isocitrate lyase HIMHAPGP_01773 1123269.NX02_11150 3.3e-268 930.6 Sphingomonadales etfD 1.5.5.1 ko:K00311 ko00000,ko01000 Bacteria 1MVU6@1224,2K0PG@204457,2TS0R@28211,COG0644@1,COG0644@2,COG2440@1,COG2440@2 NA|NA|NA C Electron transfer flavoprotein-ubiquinone oxidoreductase HIMHAPGP_01774 1234595.C725_1993 2.5e-34 152.5 unclassified Alphaproteobacteria udgA 3.2.2.27 ko:K21929 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 1MWX1@1224,2TT4Q@28211,4BQ3Q@82117,COG1573@1,COG1573@2 NA|NA|NA L Uracil DNA glycosylase superfamily HIMHAPGP_01775 595494.Tola_3107 2.1e-91 343.2 Gammaproteobacteria GO:0001503,GO:0001505,GO:0001507,GO:0001540,GO:0001649,GO:0002076,GO:0002791,GO:0002793,GO:0003674,GO:0003824,GO:0003990,GO:0004104,GO:0005488,GO:0005515,GO:0005518,GO:0005575,GO:0005576,GO:0005604,GO:0005605,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005794,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006581,GO:0006629,GO:0006644,GO:0006650,GO:0006656,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0007155,GO:0007267,GO:0007268,GO:0007271,GO:0007275,GO:0007399,GO:0007416,GO:0007517,GO:0008144,GO:0008150,GO:0008152,GO:0008283,GO:0008291,GO:0008610,GO:0008654,GO:0009056,GO:0009058,GO:0009059,GO:0009611,GO:0009987,GO:0010646,GO:0010648,GO:0010817,GO:0012505,GO:0016020,GO:0016043,GO:0016787,GO:0016788,GO:0017144,GO:0017171,GO:0019538,GO:0019637,GO:0022607,GO:0022610,GO:0023051,GO:0023052,GO:0023057,GO:0030154,GO:0031012,GO:0032222,GO:0032223,GO:0032501,GO:0032502,GO:0032879,GO:0032880,GO:0033218,GO:0034641,GO:0034645,GO:0042133,GO:0042135,GO:0042136,GO:0042165,GO:0042166,GO:0042277,GO:0042445,GO:0042447,GO:0042562,GO:0042737,GO:0042802,GO:0042803,GO:0042982,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043236,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044420,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045017,GO:0045202,GO:0046470,GO:0046474,GO:0046483,GO:0046486,GO:0046983,GO:0048468,GO:0048471,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048731,GO:0048856,GO:0048869,GO:0050708,GO:0050714,GO:0050789,GO:0050794,GO:0050804,GO:0050805,GO:0050808,GO:0050840,GO:0050896,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051222,GO:0051223,GO:0052689,GO:0061061,GO:0062023,GO:0065007,GO:0065008,GO:0070201,GO:0070405,GO:0071704,GO:0071840,GO:0071944,GO:0090087,GO:0090304,GO:0090407,GO:0097164,GO:0098916,GO:0099177,GO:0099536,GO:0099537,GO:1900619,GO:1901360,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903530,GO:1903532,GO:1904951 ko:K03929 ko00000,ko01000 CE10 Bacteria 1MVQZ@1224,1RPFW@1236,COG2272@1,COG2272@2 NA|NA|NA I Belongs to the type-B carboxylesterase lipase family HIMHAPGP_01776 69395.JQLZ01000002_gene1039 2.8e-135 489.6 Bacteria ko:K02014 ko00000,ko02000 1.B.14 Bacteria COG4773@1,COG4773@2 NA|NA|NA P Receptor HIMHAPGP_01777 1265313.HRUBRA_02031 7.2e-82 311.2 Gammaproteobacteria ko:K03292 ko00000 2.A.2 Bacteria 1MVUM@1224,1RP5J@1236,COG2211@1,COG2211@2 NA|NA|NA G COG2211 Na melibiose symporter and related transporters HIMHAPGP_01778 258594.RPA2888 3.7e-75 288.1 Bradyrhizobiaceae tpiA GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1MWK5@1224,2TS6I@28211,3JRGS@41294,COG0149@1,COG0149@2 NA|NA|NA G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) HIMHAPGP_01779 317655.Sala_3171 3.3e-136 491.9 Sphingomonadales MA20_29180 Bacteria 1MVFV@1224,2K0E5@204457,2TTV2@28211,COG4783@1,COG4783@2 NA|NA|NA S Peptidase M48 HIMHAPGP_01780 1248916.ANFY01000010_gene405 2.5e-62 245.7 Sphingomonadales dsbA Bacteria 1MY3H@1224,2K3ZK@204457,2TTXR@28211,COG1651@1,COG1651@2 NA|NA|NA O Protein-disulfide isomerase HIMHAPGP_01781 1114964.L485_14405 4e-43 181.8 Sphingomonadales MA20_23375 ko:K07043 ko00000 Bacteria 1MXZU@1224,2K287@204457,2U1JG@28211,COG1451@1,COG1451@2 NA|NA|NA S Metal-dependent hydrolase HIMHAPGP_01782 1123270.ATUR01000006_gene9 1.8e-136 492.7 Sphingomonadales ampG GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015672,GO:0015835,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1901264,GO:1902600 ko:K08218 ko01501,map01501 M00628 ko00000,ko00001,ko00002,ko02000 2.A.1.25 Bacteria 1MUZ8@1224,2K1E8@204457,2TTD2@28211,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily HIMHAPGP_01783 1234595.C725_1904 7.5e-126 457.2 Alphaproteobacteria Bacteria 1MWXW@1224,2U10Y@28211,COG4638@1,COG4638@2 NA|NA|NA P Ring hydroxylating alpha subunit (catalytic domain) HIMHAPGP_01784 1234595.C725_0134 8.6e-31 140.2 Proteobacteria marR GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042221,GO:0044212,GO:0045892,GO:0045934,GO:0046677,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071236,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 ko:K03712 ko00000,ko03000 Bacteria 1N7BV@1224,COG1846@1,COG1846@2 NA|NA|NA K transcriptional regulator HIMHAPGP_01785 1234595.C725_0135 1.8e-116 426.4 Alphaproteobacteria Bacteria 1MUZZ@1224,2TU4U@28211,COG1538@1,COG1538@2 NA|NA|NA MU RND efflux system, outer membrane lipoprotein HIMHAPGP_01786 1470591.BW41_02690 7.3e-113 414.1 Sphingomonadales ko:K03543 M00701 ko00000,ko00002,ko02000 8.A.1.1 Bacteria 1MU7I@1224,2KCZG@204457,2U3S4@28211,COG1566@1,COG1566@2 NA|NA|NA V HlyD membrane-fusion protein of T1SS HIMHAPGP_01788 1105367.CG50_09145 7.4e-30 136.3 Alphaproteobacteria Bacteria 1N0M7@1224,2DZ52@1,2UDGP@28211,32V6P@2 NA|NA|NA HIMHAPGP_01790 1030157.AFMP01000016_gene2492 6.9e-300 1036.6 Sphingomonadales ppc GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008964,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0072350 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 iJN678.ppc,iSFV_1184.SFV_4025 Bacteria 1MUD5@1224,2K1W8@204457,2TR6F@28211,COG2352@1,COG2352@2 NA|NA|NA C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle HIMHAPGP_01791 745310.G432_15430 1.4e-183 649.4 Sphingomonadales comM ko:K07391 ko00000 Bacteria 1MU4R@1224,2K1A3@204457,2TQU6@28211,COG0606@1,COG0606@2 NA|NA|NA O ATPase with chaperone activity HIMHAPGP_01793 1030157.AFMP01000031_gene2884 4.7e-22 110.9 Sphingomonadales Bacteria 1MZJ4@1224,2K5JP@204457,2UG35@28211,COG3152@1,COG3152@2 NA|NA|NA S Protein of unknown function (DUF805) HIMHAPGP_01794 1122970.AUHC01000011_gene2787 1.1e-133 483.4 Sphingomonadales Bacteria 1MV8Q@1224,2K1ZZ@204457,2TRWW@28211,COG2124@1,COG2124@2 NA|NA|NA Q cytochrome P450 HIMHAPGP_01795 1030157.AFMP01000028_gene2282 1.3e-29 135.6 Sphingomonadales gltP ko:K03309,ko:K11102,ko:K11103 ko02020,map02020 ko00000,ko00001,ko02000 2.A.23,2.A.23.1.1,2.A.23.1.2,2.A.23.1.3,2.A.23.1.6,2.A.23.1.7 Bacteria 1MU0Q@1224,2K0FM@204457,2TUFB@28211,COG1301@1,COG1301@2 NA|NA|NA C Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family HIMHAPGP_01796 579138.Zymop_1221 4.6e-19 99.8 Sphingomonadales rpmF GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904 ko:K02911 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011,ko03029 Bacteria 1PU3Y@1224,2K6RY@204457,2UF54@28211,COG0333@1,COG0333@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL32 family HIMHAPGP_01797 1248916.ANFY01000005_gene2801 1.8e-113 416.0 Sphingomonadales plsX GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0071704,GO:0090407,GO:1901576 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 iEcDH1_1363.EcDH1_2557,iSFxv_1172.SFxv_1246,iY75_1357.Y75_RS05695 Bacteria 1MVM3@1224,2K0QU@204457,2TR53@28211,COG0416@1,COG0416@2 NA|NA|NA I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA HIMHAPGP_01798 1090320.KB900605_gene858 3.4e-124 451.4 Sphingomonadales fabH 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 1MU9N@1224,2K1XQ@204457,2TR60@28211,COG0332@1,COG0332@2 NA|NA|NA I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids HIMHAPGP_01799 1123240.ATVO01000007_gene2279 1.6e-33 148.7 Sphingomonadales himA ko:K04764 ko00000,ko03032,ko03036,ko03400 Bacteria 1RH5Z@1224,2K62D@204457,2UCDG@28211,COG0776@1,COG0776@2 NA|NA|NA K This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control HIMHAPGP_01800 685778.AORL01000022_gene1429 1.6e-24 119.4 Sphingomonadales merR ko:K22491 ko00000,ko03000 Bacteria 1RGYB@1224,2K5Y3@204457,2U9A5@28211,COG0789@1,COG0789@2 NA|NA|NA K transcriptional HIMHAPGP_01801 633149.Bresu_2285 4.5e-38 164.9 Caulobacterales ko:K08988 ko00000 Bacteria 1R61N@1224,2KGU7@204458,2U5XG@28211,COG3762@1,COG3762@2 NA|NA|NA S membrane HIMHAPGP_01802 1219035.NT2_01_01460 2.4e-54 219.2 Sphingomonadales ko:K06872 ko00000 Bacteria 1PB41@1224,2K1AR@204457,2TUVD@28211,COG1512@1,COG1512@2 NA|NA|NA S Methanol dehydrogenase HIMHAPGP_01803 1248916.ANFY01000003_gene647 1.6e-63 249.2 Sphingomonadales lemA ko:K03744 ko00000 Bacteria 1MVH0@1224,2K3WZ@204457,2TRJR@28211,COG1704@1,COG1704@2 NA|NA|NA S LemA family HIMHAPGP_01804 1550073.JROH01000001_gene634 2.5e-42 178.3 Sphingomonadales mscL GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066 ko:K03282 ko00000,ko02000 1.A.22.1 Bacteria 1RHG8@1224,2K54X@204457,2U99Y@28211,COG1970@1,COG1970@2 NA|NA|NA M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell HIMHAPGP_01805 1449049.JONW01000005_gene1881 3.2e-22 112.5 Alphaproteobacteria Bacteria 1R8VC@1224,2C3WA@1,2U8X3@28211,2Z8P1@2 NA|NA|NA HIMHAPGP_01806 1122197.ATWI01000011_gene268 5.1e-19 100.9 Alteromonadaceae ko:K03668 ko00000 Bacteria 1N78G@1224,1SGIJ@1236,46DJI@72275,COG3187@1,COG3187@2 NA|NA|NA O META domain HIMHAPGP_01807 1280946.HY29_13270 1.8e-115 422.5 Hyphomonadaceae Bacteria 1MVEX@1224,2TS0Y@28211,43Z08@69657,COG3367@1,COG3367@2 NA|NA|NA S Domain of unknown function (DUF1611_N) Rossmann-like domain HIMHAPGP_01808 1163407.UU7_00717 5.3e-88 331.3 Xanthomonadales ycjG GO:0003674,GO:0003824,GO:0016853,GO:0016854,GO:0016855 5.1.1.20 ko:K19802 R10938 RC03309 ko00000,ko01000 iEC042_1314.EC042_1441,iECUMN_1333.ECUMN_1620 Bacteria 1MW76@1224,1RMKS@1236,1X5QR@135614,COG4948@1,COG4948@2 NA|NA|NA M Mandelate racemase / muconate lactonizing enzyme, C-terminal domain HIMHAPGP_01809 1280946.HY29_13265 1.6e-76 293.1 Hyphomonadaceae VPA0331 Bacteria 1PHKW@1224,2V8GI@28211,43ZVX@69657,COG0583@1,COG0583@2 NA|NA|NA K LysR substrate binding domain HIMHAPGP_01810 1123023.JIAI01000003_gene2895 4.2e-116 425.2 Pseudonocardiales MA20_04810 3.5.1.82 ko:K01461 ko00000,ko01000 Bacteria 2I8X9@201174,4E2EA@85010,COG3653@1,COG3653@2 NA|NA|NA Q Amidohydrolase family HIMHAPGP_01811 13690.CP98_02831 3.5e-137 495.4 Sphingomonadales dap 3.4.11.19 ko:K01266 ko00000,ko01000,ko01002 Bacteria 1MVPR@1224,2K5MF@204457,2TRFP@28211,COG1680@1,COG1680@2 NA|NA|NA V Beta-lactamase HIMHAPGP_01812 1114964.L485_19935 6.8e-263 913.7 Sphingomonadales Bacteria 1MU9K@1224,2KECI@204457,2UNZR@28211,COG1629@1,COG4771@2 NA|NA|NA P TonB dependent receptor HIMHAPGP_01813 745310.G432_01390 8.1e-29 134.0 Sphingomonadales dsbA 5.3.4.1 ko:K03805,ko:K03981 ko00000,ko01000,ko02044,ko03110 3.A.7.11.1 Bacteria 1MX2T@1224,2K4UR@204457,2TRAG@28211,COG1651@1,COG1651@2 NA|NA|NA O DSBA-like thioredoxin domain HIMHAPGP_01814 1248916.ANFY01000004_gene1755 1.4e-93 350.1 Sphingomonadales tetA ko:K08151,ko:K08153 M00668,M00717 ko00000,ko00002,ko01504,ko02000 2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75,2.A.1.2.8 Bacteria 1MVSH@1224,2K3DH@204457,2TUEW@28211,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily HIMHAPGP_01815 1331060.RLDS_14050 3.9e-19 101.3 Sphingomonadales 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 1N76A@1224,2KD7I@204457,2UEWG@28211,COG3743@1,COG3743@2 NA|NA|NA S rRNA binding HIMHAPGP_01816 1234595.C725_2167 1.4e-10 72.0 Proteobacteria tusA ko:K04085 ko04122,map04122 ko00000,ko00001,ko01000,ko03016 Bacteria 1MZA5@1224,COG0425@1,COG0425@2 NA|NA|NA O Sulfur carrier protein involved in sulfur trafficking in the cell. Part of a sulfur-relay system required for 2-thiolation during synthesis of 2-thiouridine of the modified wobble base 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) in tRNA. Interacts with IscS and stimulates its cysteine desulfurase activity. Accepts an activated sulfur from IscS, which is then transferred to TusD, and thus determines the direction of sulfur flow from IscS to 2-thiouridine formation. Also appears to be involved in sulfur transfer for the biosynthesis of molybdopterin HIMHAPGP_01817 685778.AORL01000010_gene2802 5.1e-21 108.6 Sphingomonadales Bacteria 1NEUN@1224,2KEI1@204457,2UIZY@28211,COG3266@1,COG3266@2 NA|NA|NA S PFAM Sporulation domain protein HIMHAPGP_01818 1331060.RLDS_07230 1.8e-190 672.2 Sphingomonadales argS GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 iAF987.Gmet_1434 Bacteria 1MU4J@1224,2K0G5@204457,2TS3Y@28211,COG0018@1,COG0018@2 NA|NA|NA J Arginyl-tRNA synthetase HIMHAPGP_01820 1122218.KB893654_gene2510 2.6e-107 395.6 Methylobacteriaceae Bacteria 1JRBN@119045,1MVUZ@1224,2TRRI@28211,COG3287@1,COG3287@2 NA|NA|NA S FIST_C HIMHAPGP_01821 349102.Rsph17025_1932 8e-78 297.0 Rhodobacter Bacteria 1FBXW@1060,1P4TD@1224,2U06A@28211,COG2197@1,COG2197@2 NA|NA|NA K Two component transcriptional regulator, LuxR family HIMHAPGP_01822 1446473.JHWH01000024_gene2807 9e-59 233.4 Paracoccus Bacteria 1R6D1@1224,2CCJC@1,2PWG5@265,2TV8P@28211,31PRJ@2 NA|NA|NA HIMHAPGP_01823 195105.CN97_17780 9.4e-85 319.7 Alphaproteobacteria MA20_34500 ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1MVUG@1224,2TSUF@28211,COG0842@1,COG0842@2 NA|NA|NA V transport, permease protein HIMHAPGP_01824 1248916.ANFY01000007_gene2201 2e-65 257.3 Sphingomonadales MA20_06380 3.5.1.68 ko:K01458 ko00340,ko00630,map00340,map00630 R00525 RC00165,RC00323 ko00000,ko00001,ko01000 Bacteria 1MY4D@1224,2K41R@204457,2TUPZ@28211,COG3741@1,COG3741@2 NA|NA|NA E N-formylglutamate amidohydrolase HIMHAPGP_01825 1219035.NT2_01_05840 2.2e-147 528.9 Sphingomonadales Bacteria 1MY5H@1224,2K5DY@204457,2TTRR@28211,COG2124@1,COG2124@2 NA|NA|NA Q Cytochrome P450 HIMHAPGP_01826 1219035.NT2_01_05660 6.4e-181 640.2 Sphingomonadales GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0008410,GO:0015977,GO:0016740,GO:0016782,GO:0043427,GO:0071704 2.8.3.16,2.8.3.20 ko:K07749,ko:K18313 R10640,R10641 RC00014 ko00000,ko01000 Bacteria 1MU2K@1224,2K0PV@204457,2TR7Q@28211,COG1804@1,COG1804@2 NA|NA|NA C dehydratase HIMHAPGP_01827 1219035.NT2_01_05680 2.7e-16 91.7 Sphingomonadales Bacteria 1RCYI@1224,2DRHM@1,2KC6N@204457,2UAAG@28211,32UR4@2 NA|NA|NA HIMHAPGP_01828 1219035.NT2_01_05690 3.2e-112 411.8 Sphingomonadales MA20_16375 Bacteria 1MY0Y@1224,2K1BV@204457,2TRMW@28211,COG3173@1,COG3173@2 NA|NA|NA S Phosphotransferase enzyme family HIMHAPGP_01829 1219035.NT2_01_05700 1.4e-188 665.6 Sphingomonadales Bacteria 1NX52@1224,2K13I@204457,2TSJM@28211,COG1073@1,COG1073@2 NA|NA|NA I Alpha beta hydrolase HIMHAPGP_01830 1219035.NT2_01_05710 3.3e-66 258.1 Sphingomonadales Bacteria 1MWCV@1224,2KDAG@204457,2UEQ6@28211,COG0346@1,COG0346@2 NA|NA|NA E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily HIMHAPGP_01831 1248916.ANFY01000017_gene1470 1.8e-86 325.9 Sphingomonadales thiD 2.7.1.49,2.7.4.7 ko:K00941 ko00730,ko01100,map00730,map01100 M00127 R03471,R04509 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 1MU9J@1224,2K24Q@204457,2TUKR@28211,COG0346@1,COG0346@2,COG0351@1,COG0351@2 NA|NA|NA H Phosphomethylpyrimidine kinase HIMHAPGP_01832 1248916.ANFY01000017_gene1472 5.5e-173 614.0 Sphingomonadales glmM GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006464,GO:0006468,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008966,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019538,GO:0034641,GO:0034654,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046777,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 R02060 RC00408 ko00000,ko00001,ko01000 iSBO_1134.SBO_3206 Bacteria 1MU24@1224,2JZV4@204457,2TQWH@28211,COG1109@1,COG1109@2 NA|NA|NA G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate HIMHAPGP_01833 1449076.JOOE01000001_gene1980 2.6e-268 931.0 Sphingomonadales ilvD GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUTQ@1224,2K026@204457,2TRTQ@28211,COG0129@1,COG0129@2 NA|NA|NA EG Belongs to the IlvD Edd family HIMHAPGP_01834 1234595.C725_0694 1.1e-64 252.7 Alphaproteobacteria 1.3.99.16 ko:K07302,ko:K07303 ko00000,ko01000 Bacteria 1RD8C@1224,2U6Z6@28211,COG2080@1,COG2080@2 NA|NA|NA C COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs HIMHAPGP_01836 1114964.L485_01180 1.6e-40 172.6 Bacteria Bacteria COG1082@1,COG1082@2 NA|NA|NA G myo-inosose-2 dehydratase activity HIMHAPGP_01837 13689.BV96_04333 3.9e-40 171.0 Sphingomonadales Bacteria 1MXTN@1224,2KAZ3@204457,2TYT4@28211,COG3039@1,COG3039@2 NA|NA|NA L Transposase HIMHAPGP_01838 1547437.LL06_26400 2.4e-65 255.0 Phyllobacteriaceae Bacteria 1N7IY@1224,2U993@28211,43KZ0@69277,COG3865@1,COG3865@2 NA|NA|NA S 3-demethylubiquinone-9 3-methyltransferase HIMHAPGP_01840 1123270.ATUR01000005_gene514 5e-122 444.5 Sphingomonadales Bacteria 1MUB7@1224,2K14F@204457,2TQQ0@28211,COG0438@1,COG0438@2 NA|NA|NA M Glycosyl transferase HIMHAPGP_01841 1123240.ATVO01000004_gene1002 1.2e-61 243.0 Sphingomonadales Bacteria 1N0PI@1224,2EN5S@1,2K66Q@204457,2UST7@28211,33FTP@2 NA|NA|NA S PEP-CTERM motif HIMHAPGP_01842 1248916.ANFY01000003_gene675 0.0 1783.8 Sphingomonadales rpoC GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03046,ko:K13797 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 Bacteria 1MU3M@1224,2K1CM@204457,2TRHV@28211,COG0086@1,COG0086@2 NA|NA|NA K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates HIMHAPGP_01843 1112212.JH584235_gene1830 1.4e-28 132.5 Sphingomonadales Bacteria 1NIVD@1224,2C0YA@1,2K6ZT@204457,2UKNB@28211,3437Q@2 NA|NA|NA HIMHAPGP_01844 1248916.ANFY01000003_gene538 1e-94 353.2 Sphingomonadales ahyR ko:K07782,ko:K15852 ko02020,ko02024,ko02026,map02020,map02024,map02026 ko00000,ko00001,ko03000 Bacteria 1R6UF@1224,2K2AM@204457,2TU0V@28211,COG2197@1,COG2197@2 NA|NA|NA K helix_turn_helix, Lux Regulon HIMHAPGP_01846 1120705.FG95_01896 1.3e-41 177.2 Sphingomonadales Bacteria 1NYGB@1224,2DKZK@1,2K6K3@204457,2UTDG@28211,310GY@2 NA|NA|NA S Protein of unknown function (DUF3011) HIMHAPGP_01847 1219035.NT2_09_01100 2.4e-59 236.1 Sphingomonadales mprF GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.3.2.3 ko:K07027,ko:K14205 ko01503,ko02020,ko05150,map01503,map02020,map05150 M00726 ko00000,ko00001,ko00002,ko01000,ko01504,ko02000 2.A.1.3.37,4.D.2 iYO844.BG12900 Bacteria 1MXH9@1224,2K1W7@204457,2TUMC@28211,COG0392@1,COG0392@2,COG2898@1,COG2898@2 NA|NA|NA S Uncharacterised conserved protein (DUF2156) HIMHAPGP_01848 1248917.ANFX01000035_gene1948 7.5e-152 543.5 Sphingomonadales rfbB 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 Bacteria 1MU5E@1224,2K275@204457,2TT5T@28211,COG1088@1,COG1088@2 NA|NA|NA M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily HIMHAPGP_01849 1248916.ANFY01000005_gene2780 4.6e-96 357.8 Sphingomonadales rfbD 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 iJN678.rfbD Bacteria 1MUXM@1224,2K002@204457,2TSP6@28211,COG1091@1,COG1091@2 NA|NA|NA M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose HIMHAPGP_01850 1248916.ANFY01000005_gene2781 2.6e-68 265.0 Sphingomonadales rmlC 5.1.3.13 ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R06514 RC01531 ko00000,ko00001,ko00002,ko01000 Bacteria 1R9YD@1224,2K456@204457,2U7G8@28211,COG1898@1,COG1898@2 NA|NA|NA M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose HIMHAPGP_01851 1331060.RLDS_13355 9.4e-129 466.5 Sphingomonadales rfbA GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0005996,GO:0006006,GO:0006139,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008879,GO:0009058,GO:0009059,GO:0009117,GO:0009141,GO:0009147,GO:0009200,GO:0009211,GO:0009219,GO:0009225,GO:0009226,GO:0009262,GO:0009394,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019299,GO:0019300,GO:0019305,GO:0019318,GO:0019319,GO:0019438,GO:0019637,GO:0019692,GO:0030312,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0045226,GO:0046075,GO:0046364,GO:0046379,GO:0046383,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv0334 Bacteria 1MU0X@1224,2K0S0@204457,2TQPI@28211,COG1209@1,COG1209@2 NA|NA|NA M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis HIMHAPGP_01852 13690.CP98_04536 5.7e-108 397.9 Sphingomonadales 1.12.98.1 ko:K00441 ko00680,ko01100,ko01120,map00680,map01100,map01120 R03025 RC02628 ko00000,ko00001,ko01000 Bacteria 1R45V@1224,2K1DY@204457,2U2DM@28211,COG1035@1,COG1035@2 NA|NA|NA C Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus HIMHAPGP_01853 1286631.X805_32790 2.4e-79 302.8 Proteobacteria ko:K16710 ko00000 Bacteria 1MXWP@1224,COG2327@1,COG2327@2 NA|NA|NA S Polysaccharide pyruvyl transferase HIMHAPGP_01854 1248916.ANFY01000005_gene2783 3.2e-54 219.2 Sphingomonadales 5.2.1.8 ko:K03770 ko00000,ko01000,ko03110 Bacteria 1R4EF@1224,2K2VB@204457,2UI6W@28211,COG0760@1,COG0760@2 NA|NA|NA O TIGRFAM peptidyl-prolyl cis-trans isomerase, EpsD family HIMHAPGP_01855 1248916.ANFY01000005_gene2784 4.6e-64 251.9 Bacteria ko:K07011 ko00000 Bacteria COG1216@1,COG1216@2 NA|NA|NA V Glycosyl transferase, family 2 HIMHAPGP_01856 1121022.ABENE_14890 2.6e-171 608.6 Alphaproteobacteria ko:K06610,ko:K08369 ko00000,ko02000 2.A.1,2.A.1.1.27 Bacteria 1R3UK@1224,2UAWH@28211,COG0738@1,COG0738@2 NA|NA|NA G Major Facilitator Superfamily HIMHAPGP_01857 450851.PHZ_c2158 6.9e-96 357.5 Caulobacterales ko:K05499 ko00000,ko03000 Bacteria 1MVUR@1224,2KG75@204458,2U22N@28211,COG1609@1,COG1609@2 NA|NA|NA K Transcriptional regulator HIMHAPGP_01858 1335760.ASTG01000003_gene1553 5.2e-76 290.8 Sphingomonadales maiA 5.2.1.2,5.2.1.4 ko:K01800,ko:K01801 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R03181,R03868 RC00867 ko00000,ko00001,ko00002,ko01000 Bacteria 1RA4Y@1224,2K49D@204457,2U5B6@28211,COG0625@1,COG0625@2 NA|NA|NA O maleylacetoacetate isomerase HIMHAPGP_01859 1088721.NSU_0843 2.4e-181 641.7 Sphingomonadales fahA 3.7.1.2 ko:K01555 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R01364 RC00326,RC00446 ko00000,ko00001,ko00002,ko01000,ko04147 iJN746.PP_4620 Bacteria 1MW82@1224,2K0SS@204457,2TRKH@28211,COG0179@1,COG0179@2 NA|NA|NA Q Fumarylacetoacetase HIMHAPGP_01860 13690.CP98_02330 9.7e-199 699.5 Sphingomonadales hmgA 1.13.11.5 ko:K00451 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R02519 RC00737 ko00000,ko00001,ko00002,ko01000 Bacteria 1MV9G@1224,2K0UM@204457,2TRFI@28211,COG3508@1,COG3508@2 NA|NA|NA Q Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate HIMHAPGP_01861 1114964.L485_07580 4.3e-176 624.0 Sphingomonadales hppD GO:0001897,GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0003868,GO:0006082,GO:0006520,GO:0006570,GO:0006572,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009987,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019752,GO:0019835,GO:0019836,GO:0031640,GO:0035821,GO:0043436,GO:0044003,GO:0044004,GO:0044179,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044364,GO:0044403,GO:0044419,GO:0044764,GO:0046395,GO:0051213,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0055114,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.13.11.27 ko:K00457 ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100 M00044 R01372,R02521 RC00505,RC00738 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1MUVZ@1224,2K0BD@204457,2TRCC@28211,COG3185@1,COG3185@2 NA|NA|NA E 4-hydroxyphenylpyruvate dioxygenase HIMHAPGP_01862 1114964.L485_07585 8.9e-124 449.9 Sphingomonadales phhA GO:0003674,GO:0003824,GO:0004497,GO:0004505,GO:0006082,GO:0006520,GO:0006558,GO:0006559,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009987,GO:0016054,GO:0016491,GO:0016705,GO:0016714,GO:0017144,GO:0019439,GO:0019752,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902221,GO:1902222 1.14.16.1 ko:K00500 ko00360,ko00400,ko00790,ko01100,ko01230,map00360,map00400,map00790,map01100,map01230 R01795,R07211 RC00490 ko00000,ko00001,ko01000 Bacteria 1MU29@1224,2K01F@204457,2TU1E@28211,COG3186@1,COG3186@2 NA|NA|NA E Phenylalanine-4-hydroxylase HIMHAPGP_01863 13690.CP98_04607 3.4e-58 231.1 Sphingomonadales ko:K03719,ko:K05800 ko00000,ko03000,ko03036 Bacteria 1RIZA@1224,2K5J8@204457,2UBJK@28211,COG1522@1,COG1522@2 NA|NA|NA K helix_turn_helix ASNC type HIMHAPGP_01864 1387312.BAUS01000011_gene1931 6.1e-38 164.1 Proteobacteria Bacteria 1PAZC@1224,2EHXA@1,33BNW@2 NA|NA|NA S PEP-CTERM motif HIMHAPGP_01865 1248916.ANFY01000009_gene252 1.6e-121 442.6 Sphingomonadales pdxA GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008614,GO:0008615,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0036094,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046184,GO:0046483,GO:0046872,GO:0046914,GO:0048037,GO:0050570,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 1.1.1.262,1.1.1.408,1.1.1.409 ko:K00097,ko:K22024 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 iECO111_1330.ECO111_0056 Bacteria 1MX5W@1224,2K0HZ@204457,2TSKF@28211,COG1995@1,COG1995@2 NA|NA|NA H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) HIMHAPGP_01866 1030157.AFMP01000019_gene628 7e-89 334.0 Sphingomonadales ksgA GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 ko:K02528 R10716 RC00003,RC03257 ko00000,ko01000,ko03009 Bacteria 1MVNU@1224,2K042@204457,2TRD9@28211,COG0030@1,COG0030@2 NA|NA|NA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits HIMHAPGP_01867 1123269.NX02_17905 1.7e-23 115.9 Sphingomonadales Bacteria 1RITF@1224,2K5C0@204457,2UAIQ@28211,COG4704@1,COG4704@2 NA|NA|NA S Uncharacterized protein conserved in bacteria (DUF2141) HIMHAPGP_01868 745310.G432_06160 2e-137 495.7 Sphingomonadales lptF ko:K07091,ko:K11720 ko02010,map02010 M00320 ko00000,ko00001,ko00002,ko02000 1.B.42.1 Bacteria 1MUF2@1224,2K07C@204457,2U55Q@28211,COG0795@1,COG0795@2 NA|NA|NA S YjgP YjgQ family HIMHAPGP_01869 1248916.ANFY01000007_gene2604 1.9e-110 406.0 Sphingomonadales lptG ko:K11720 ko02010,map02010 M00320 ko00000,ko00001,ko00002,ko02000 1.B.42.1 Bacteria 1MVW3@1224,2K1ZM@204457,2TR76@28211,COG0795@1,COG0795@2 NA|NA|NA S YjgP YjgQ family HIMHAPGP_01870 1123267.JONN01000001_gene420 5.2e-94 350.9 Sphingomonadales Bacteria 1RC8C@1224,2K0MJ@204457,2U5FU@28211,COG3000@1,COG3000@2 NA|NA|NA I Fatty acid hydroxylase HIMHAPGP_01871 1248916.ANFY01000007_gene2605 3.2e-137 495.0 Sphingomonadales yghO GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141 Bacteria 1PMA3@1224,2K0BS@204457,2TUU2@28211,COG0454@1,COG0456@2 NA|NA|NA K acetyltransferase HIMHAPGP_01872 1192759.AKIB01000009_gene2573 4.6e-09 68.6 Alphaproteobacteria ko:K02282,ko:K07782,ko:K19135 ko02020,ko02024,ko02026,map02020,map02024,map02026 ko00000,ko00001,ko02035,ko02044,ko02048,ko03000 Bacteria 1R2FV@1224,2UMYH@28211,COG2197@1,COG2197@2 NA|NA|NA KT helix_turn_helix, Lux Regulon HIMHAPGP_01873 69395.JQLZ01000001_gene3149 3.8e-12 77.8 Caulobacterales Bacteria 1NBKJ@1224,2DPV3@1,2KHIX@204458,2UIZH@28211,333H6@2 NA|NA|NA HIMHAPGP_01874 314266.SKA58_14827 1.9e-15 89.0 Sphingomonadales Bacteria 1NI0K@1224,2EP5S@1,2K7J5@204457,2UK2B@28211,33GSG@2 NA|NA|NA HIMHAPGP_01875 629773.AORY01000004_gene209 2.2e-29 136.0 Sphingomonadales radC ko:K03630 ko00000 Bacteria 1MXZ5@1224,2K0WQ@204457,2TQXM@28211,COG2003@1,COG2003@2 NA|NA|NA L Belongs to the UPF0758 family HIMHAPGP_01876 627192.SLG_36010 3.7e-89 334.7 Sphingomonadales xthA 3.1.11.2 ko:K01142 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 1MVII@1224,2K0HF@204457,2TR5J@28211,COG0708@1,COG0708@2 NA|NA|NA L exodeoxyribonuclease III HIMHAPGP_01877 1219049.SP5_074_00140 1e-32 146.4 Sphingomonadales erpA ko:K07400,ko:K13628,ko:K15724 ko00000,ko03016 Bacteria 1RHCW@1224,2K54P@204457,2UBR8@28211,COG0316@1,COG0316@2 NA|NA|NA S Belongs to the HesB IscA family HIMHAPGP_01878 745310.G432_06200 1.7e-64 253.4 Sphingomonadales Bacteria 1MVTF@1224,2K148@204457,2TQZE@28211,COG0739@1,COG0739@2 NA|NA|NA M COG0739 Membrane proteins related to metalloendopeptidases HIMHAPGP_01879 1234595.C725_1511 3e-76 292.0 Alphaproteobacteria 2.7.1.165 ko:K11529 ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200 M00346 R08572 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 Bacteria 1MW0V@1224,2TQJU@28211,COG2833@1,COG2833@2 NA|NA|NA S protein conserved in bacteria HIMHAPGP_01880 450851.PHZ_c1836 2e-53 215.3 Caulobacterales bcp 1.11.1.15,2.7.7.42,2.7.7.89 ko:K00982,ko:K03564 ko00000,ko01000 Bacteria 1RD4R@1224,2KGSV@204458,2U6Z9@28211,COG1225@1,COG1225@2 NA|NA|NA O PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HIMHAPGP_01881 1123240.ATVO01000008_gene2450 2.8e-216 758.8 Sphingomonadales glnE GO:0000166,GO:0000287,GO:0000820,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006521,GO:0006541,GO:0006542,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008882,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0010565,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0019222,GO:0019752,GO:0030554,GO:0031323,GO:0032553,GO:0032555,GO:0032559,GO:0033238,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.42,2.7.7.89 ko:K00982 ko00000,ko01000 Bacteria 1MU4I@1224,2K1YP@204457,2TRY7@28211,COG1391@1,COG1391@2 NA|NA|NA H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell HIMHAPGP_01882 1112212.JH584235_gene2628 2.4e-81 308.9 Sphingomonadales panC GO:0003674,GO:0003824,GO:0004592,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 iECH74115_1262.ECH74115_0142,iECSP_1301.ECSP_0134,iECs_1301.ECs0137,iG2583_1286.G2583_0137,iZ_1308.Z0144 Bacteria 1MV1S@1224,2K0S2@204457,2TS2D@28211,COG0414@1,COG0414@2 NA|NA|NA H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate HIMHAPGP_01883 685778.AORL01000022_gene1409 2.1e-82 312.4 Sphingomonadales mipZ ko:K03496 ko00000,ko03036,ko04812 Bacteria 1MVKR@1224,2K06A@204457,2TRZY@28211,COG1192@1,COG1192@2 NA|NA|NA D involved in chromosome partitioning HIMHAPGP_01885 1248916.ANFY01000017_gene1450 1.1e-65 256.5 Sphingomonadales cynT GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0008150,GO:0008270,GO:0015976,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043169,GO:0046872,GO:0046914 4.2.1.1 ko:K01673 ko00910,map00910 R00132,R10092 RC02807 ko00000,ko00001,ko01000 Bacteria 1MV1U@1224,2KDW2@204457,2VEYE@28211,COG0288@1,COG0288@2 NA|NA|NA P Reversible hydration of carbon dioxide HIMHAPGP_01886 1248916.ANFY01000017_gene1452 7.1e-192 676.8 Sphingomonadales lpdA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1MU2U@1224,2JZWH@204457,2TR8H@28211,COG1249@1,COG1249@2 NA|NA|NA C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes HIMHAPGP_01888 745310.G432_08190 3.7e-131 474.9 Sphingomonadales pdhC 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1MUGY@1224,2K0EK@204457,2TRXM@28211,COG0508@1,COG0508@2 NA|NA|NA C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) HIMHAPGP_01889 745310.G432_04565 5.6e-92 345.1 Sphingomonadales lnt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016021,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576 ko:K03820 ko00000,ko01000 GT2 iEcSMS35_1347.EcSMS35_0678,iSbBS512_1146.SbBS512_E0590 Bacteria 1MUBU@1224,2K1Y8@204457,2TQRC@28211,COG0815@1,COG0815@2 NA|NA|NA M Transfers the fatty acyl group on membrane lipoproteins HIMHAPGP_01890 745310.G432_04100 1.3e-62 246.5 Sphingomonadales trmJ GO:0001510,GO:0002128,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.200,3.5.1.19,6.1.1.16 ko:K01883,ko:K02533,ko:K07461,ko:K08281,ko:K15396 ko00760,ko00970,ko01100,map00760,map00970,map01100 M00359,M00360 R01268,R03650 RC00055,RC00100,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 1N47Y@1224,2JZUG@204457,2TS8J@28211,COG0565@1,COG0565@2,COG2827@1,COG2827@2 NA|NA|NA J Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA HIMHAPGP_01891 195105.CN97_00510 3.3e-64 251.9 Alphaproteobacteria Bacteria 1MWVI@1224,2TRSP@28211,COG0745@1,COG0745@2 NA|NA|NA KT COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain HIMHAPGP_01892 1174684.EBMC1_00345 7.5e-26 123.6 Sphingomonadales MA20_11245 Bacteria 1RGVA@1224,2AMHV@1,2K54G@204457,2U98Q@28211,31CDG@2 NA|NA|NA S Protein of unknown function (DUF1153) HIMHAPGP_01893 1234595.C725_1642 5.4e-119 434.5 unclassified Alphaproteobacteria mnmA 2.8.1.13 ko:K00566 ko04122,map04122 R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 Bacteria 1MUT1@1224,2TQU7@28211,4BPBG@82117,COG0482@1,COG0482@2 NA|NA|NA J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 HIMHAPGP_01894 1044.EH31_10935 4e-108 397.9 Sphingomonadales ko:K15727 ko00000,ko02000 8.A.1.2.1 Bacteria 1R91T@1224,2K7HG@204457,2TRDQ@28211,COG0803@1,COG0803@2 NA|NA|NA P ChrR Cupin-like domain HIMHAPGP_01895 1549858.MC45_14725 6.7e-09 68.6 Sphingomonadales Bacteria 1RF95@1224,2E521@1,2K2DR@204457,2U8QW@28211,32ZVA@2 NA|NA|NA S zinc-ribbon domain HIMHAPGP_01896 1030157.AFMP01000014_gene3384 1e-38 166.8 Sphingomonadales MA20_20455 Bacteria 1RHMV@1224,2K4KS@204457,2U957@28211,COG1434@1,COG1434@2 NA|NA|NA S DUF218 domain HIMHAPGP_01897 1248916.ANFY01000008_gene2068 4.6e-54 218.0 Sphingomonadales plsC 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 1MY51@1224,2K3XJ@204457,2TT3P@28211,COG0204@1,COG0204@2 NA|NA|NA I Acyltransferase HIMHAPGP_01900 279238.Saro_0171 8.2e-11 73.6 Sphingomonadales xseA 3.1.11.6 ko:K03601 ko03430,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 1MUA4@1224,2K05G@204457,2TR1R@28211,COG1570@1,COG1570@2 NA|NA|NA L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides HIMHAPGP_01901 1234595.C725_2387 4.1e-17 93.6 unclassified Alphaproteobacteria MA20_05765 Bacteria 1Q66H@1224,2VEEJ@28211,4BSYD@82117,COG3908@1,COG3908@2 NA|NA|NA S Uncharacterized protein conserved in bacteria (DUF2093) HIMHAPGP_01902 1346791.M529_17710 0.0 1240.7 Sphingomonadales ko:K02014 ko00000,ko02000 1.B.14 Bacteria 1MU9K@1224,2JZUI@204457,2TTJG@28211,COG1629@1,COG4206@1,COG4206@2,COG4771@2 NA|NA|NA P COG1629 Outer membrane receptor proteins, mostly Fe transport HIMHAPGP_01903 1192759.AKIB01000043_gene421 3.7e-84 318.5 Sphingomonadales Bacteria 1N0AE@1224,2ASJY@1,2K162@204457,2UCJQ@28211,31I0J@2 NA|NA|NA HIMHAPGP_01904 1346791.M529_16960 8e-129 467.2 Sphingomonadales ko:K12979 ko00000,ko01000,ko01005 Bacteria 1MW3M@1224,2KD8F@204457,2TRVQ@28211,COG3555@1,COG3555@2 NA|NA|NA O Aspartyl/Asparaginyl beta-hydroxylase HIMHAPGP_01905 1144307.PMI04_00652 9.6e-19 99.4 Sphingomonadales Bacteria 1PNXZ@1224,2ABFU@1,2KBJG@204457,2V1H6@28211,310WS@2 NA|NA|NA HIMHAPGP_01906 702113.PP1Y_AT19047 2.5e-77 295.0 Sphingomonadales clpB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009408,GO:0009628,GO:0010033,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0031249,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0035966,GO:0036094,GO:0042221,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 ko:K03694,ko:K03695 ko04213,map04213 ko00000,ko00001,ko03110 Bacteria 1MURH@1224,2K00X@204457,2TRKI@28211,COG0542@1,COG0542@2 NA|NA|NA O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE HIMHAPGP_01907 1123240.ATVO01000005_gene1909 2.6e-114 418.3 Sphingomonadales fadJ 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 Bacteria 1MU9P@1224,2K2HG@204457,2TS8E@28211,COG1024@1,COG1024@2,COG1250@1,COG1250@2 NA|NA|NA I 3-hydroxyacyl-CoA dehydrogenase HIMHAPGP_01908 1248916.ANFY01000003_gene687 4.4e-116 424.5 Sphingomonadales 1.3.1.9 ko:K02371 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 1MU2F@1224,2KCQW@204457,2U3PD@28211,COG2070@1,COG2070@2 NA|NA|NA S Nitronate monooxygenase HIMHAPGP_01909 1090319.KE386571_gene777 4.8e-30 137.1 Sphingomonadales MA20_43795 Bacteria 1MZHB@1224,2CCMQ@1,2K53Z@204457,2UCC9@28211,32RW3@2 NA|NA|NA S Protein of unknown function (DUF2794) HIMHAPGP_01910 392499.Swit_3585 2e-78 298.9 Sphingomonadales cysE GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009001,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 iJN746.PP_0840 Bacteria 1MVFX@1224,2K2GH@204457,2TQQ5@28211,COG1045@1,COG1045@2 NA|NA|NA E serine acetyltransferase HIMHAPGP_01911 1449076.JOOE01000002_gene1246 3.4e-63 248.4 Sphingomonadales ytnM ko:K07090 ko00000 Bacteria 1PGTZ@1224,2K1II@204457,2U5IZ@28211,COG0730@1,COG0730@2 NA|NA|NA S membrane transporter protein HIMHAPGP_01912 1123267.JONN01000001_gene1470 3.1e-80 305.1 Sphingomonadales ytnM ko:K07090 ko00000 Bacteria 1PGTZ@1224,2K1II@204457,2U5IZ@28211,COG0730@1,COG0730@2 NA|NA|NA S membrane transporter protein HIMHAPGP_01913 745310.G432_14685 4.8e-96 357.8 Sphingomonadales 5.2.1.8 ko:K01802,ko:K03767,ko:K03768 ko01503,ko04217,map01503,map04217 ko00000,ko00001,ko01000,ko03110,ko04147 Bacteria 1QCY4@1224,2K25P@204457,2U56N@28211,COG0652@1,COG0652@2 NA|NA|NA O peptidyl-prolyl cis-trans isomerase HIMHAPGP_01914 194867.ALBQ01000059_gene3366 3.5e-102 378.3 Sphingomonadales oxyR ko:K04761 ko02026,map02026 ko00000,ko00001,ko03000 Bacteria 1MVA1@1224,2K012@204457,2TSUS@28211,COG0583@1,COG0583@2 NA|NA|NA K Transcriptional regulator HIMHAPGP_01915 1248916.ANFY01000005_gene2747 3.3e-143 514.6 Sphingomonadales qor2 1.6.5.5 ko:K00344 ko00000,ko01000 Bacteria 1MWRK@1224,2K1HA@204457,2TQMF@28211,COG0604@1,COG0604@2 NA|NA|NA C COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases HIMHAPGP_01916 78245.Xaut_2347 1e-37 162.9 Xanthobacteraceae moaE 2.8.1.12 ko:K03635 ko00790,ko01100,ko04122,map00790,map01100,map04122 R09395 RC02507 ko00000,ko00001,ko01000 Bacteria 1RGUX@1224,2U73K@28211,3EZFY@335928,COG0314@1,COG0314@2 NA|NA|NA H MoaE protein HIMHAPGP_01917 1550073.JROH01000011_gene2025 1.1e-18 99.0 Sphingomonadales moaD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.12 ko:K03636,ko:K21142 ko00790,ko01100,ko04122,map00790,map01100,map04122 R09395 RC02507 ko00000,ko00001,ko01000 Bacteria 1N0IE@1224,2K6UZ@204457,2UF4F@28211,COG1977@1,COG1977@2 NA|NA|NA H Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin HIMHAPGP_01918 1234595.C725_2019 1.5e-66 259.2 unclassified Alphaproteobacteria pgsA GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0031224,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 iAF1260.b1912,iAPECO1_1312.APECO1_954,iB21_1397.B21_01866,iBWG_1329.BWG_1721,iE2348C_1286.E2348C_2030,iEC042_1314.EC042_2073,iEC55989_1330.EC55989_2132,iECABU_c1320.ECABU_c21710,iECBD_1354.ECBD_1731,iECB_1328.ECB_01877,iECDH10B_1368.ECDH10B_2053,iECDH1ME8569_1439.ECDH1ME8569_1852,iECD_1391.ECD_01877,iECED1_1282.ECED1_2177,iECH74115_1262.ECH74115_2684,iECIAI1_1343.ECIAI1_1996,iECIAI39_1322.ECIAI39_1143,iECNA114_1301.ECNA114_2003,iECO103_1326.ECO103_2168,iECO111_1330.ECO111_2492,iECO26_1355.ECO26_2804,iECOK1_1307.ECOK1_2029,iECP_1309.ECP_1852,iECS88_1305.ECS88_1966,iECSF_1327.ECSF_1764,iECSP_1301.ECSP_2516,iECUMN_1333.ECUMN_2204,iECs_1301.ECs2650,iETEC_1333.ETEC_2020,iEcDH1_1363.EcDH1_1734,iEcE24377_1341.EcE24377A_2145,iEcHS_1320.EcHS_A2010,iEcSMS35_1347.EcSMS35_1271,iEcolC_1368.EcolC_1727,iG2583_1286.G2583_2363,iJO1366.b1912,iJR904.b1912,iLF82_1304.LF82_1635,iNRG857_1313.NRG857_09550,iSDY_1059.SDY_1106,iSSON_1240.SSON_1206,iSbBS512_1146.SbBS512_E1039,iUMN146_1321.UM146_07620,iUMNK88_1353.UMNK88_2386,iUTI89_1310.UTI89_C2113,iY75_1357.Y75_RS10025,iYL1228.KPN_02410,iZ_1308.Z3000,ic_1306.c2325 Bacteria 1RCZ7@1224,2TUI7@28211,4BQGN@82117,COG0558@1,COG0558@2 NA|NA|NA I Belongs to the CDP-alcohol phosphatidyltransferase class-I family HIMHAPGP_01919 264198.Reut_B3607 2.3e-87 328.6 Burkholderiaceae Bacteria 1K24T@119060,1PG8V@1224,2VKIZ@28216,COG0778@1,COG0778@2 NA|NA|NA C nitroreductase HIMHAPGP_01921 702113.PP1Y_AT25461 1.7e-88 332.4 Sphingomonadales Bacteria 1MX5C@1224,2K1CX@204457,2TRE6@28211,COG1432@1,COG1432@2 NA|NA|NA S OST-HTH/LOTUS domain HIMHAPGP_01922 745310.G432_01125 1.4e-135 489.2 Sphingomonadales lipA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 R07767,R07768 RC01978 ko00000,ko00001,ko01000 iAPECO1_1312.APECO1_1427,iB21_1397.B21_00586,iBWG_1329.BWG_0499,iE2348C_1286.E2348C_0528,iEC55989_1330.EC55989_0620,iECABU_c1320.ECABU_c06820,iECBD_1354.ECBD_3023,iECB_1328.ECB_00597,iECDH10B_1368.ECDH10B_0589,iECDH1ME8569_1439.ECDH1ME8569_0597,iECD_1391.ECD_00597,iECED1_1282.ECED1_0624,iECH74115_1262.ECH74115_0716,iECIAI1_1343.ECIAI1_0611,iECIAI39_1322.ECIAI39_0603,iECNA114_1301.ECNA114_0567,iECO103_1326.ECO103_0635,iECO111_1330.ECO111_0658,iECO26_1355.ECO26_0702,iECOK1_1307.ECOK1_0638,iECP_1309.ECP_0658,iECS88_1305.ECS88_0669,iECSE_1348.ECSE_0695,iECSF_1327.ECSF_0567,iECSP_1301.ECSP_0681,iECUMN_1333.ECUMN_0720,iECW_1372.ECW_m0682,iECs_1301.ECs0666,iEKO11_1354.EKO11_3238,iETEC_1333.ETEC_0656,iEcDH1_1363.EcDH1_2998,iEcE24377_1341.EcE24377A_0652,iEcHS_1320.EcHS_A0679,iEcSMS35_1347.EcSMS35_0648,iEcolC_1368.EcolC_3017,iG2583_1286.G2583_0791,iJO1366.b0628,iLF82_1304.LF82_1199,iNRG857_1313.NRG857_02855,iSBO_1134.SBO_0492,iSDY_1059.SDY_0550,iSF_1195.SF0653,iSFxv_1172.SFxv_0720,iSSON_1240.SSON_0582,iS_1188.S0675,iSbBS512_1146.SbBS512_E0542,iUMN146_1321.UM146_14375,iUMNK88_1353.UMNK88_663,iUTI89_1310.UTI89_C0631,iWFL_1372.ECW_m0682,iY75_1357.Y75_RS03275,ic_1306.c0718 Bacteria 1MVRD@1224,2K1H4@204457,2TRP3@28211,COG0320@1,COG0320@2 NA|NA|NA H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives HIMHAPGP_01923 279238.Saro_1922 6e-45 187.2 Sphingomonadales MA20_29700 ko:K18588 ko00000 Bacteria 1RGUH@1224,2K41W@204457,2U7D8@28211,COG2867@1,COG2867@2 NA|NA|NA I Oligoketide cyclase lipid transport protein HIMHAPGP_01924 1123240.ATVO01000003_gene222 1.5e-51 209.1 Sphingomonadales cinA 3.5.1.42 ko:K03742,ko:K03743 ko00760,map00760 R02322 RC00100 ko00000,ko00001,ko01000 Bacteria 1RH2Y@1224,2K40Q@204457,2U94H@28211,COG1546@1,COG1546@2 NA|NA|NA S Belongs to the CinA family HIMHAPGP_01925 1234595.C725_0071 5.6e-114 417.9 unclassified Alphaproteobacteria ispF GO:0000166,GO:0000287,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008299,GO:0008610,GO:0008654,GO:0008685,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016114,GO:0016740,GO:0016772,GO:0016779,GO:0016829,GO:0016849,GO:0019103,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044464,GO:0046490,GO:0046872,GO:0046914,GO:0050518,GO:0051483,GO:0051484,GO:0070567,GO:0071704,GO:0071944,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.405,2.1.1.228,2.7.7.40,2.7.7.60,4.6.1.12 ko:K00554,ko:K00991,ko:K01770,ko:K12506,ko:K21681 ko00040,ko00900,ko01100,ko01110,ko01130,map00040,map00900,map01100,map01110,map01130 M00096 R00597,R01525,R02921,R05633,R05637 RC00002,RC00003,RC00089,RC00334,RC01440 ko00000,ko00001,ko00002,ko01000,ko03016 iNJ661.Rv3581c Bacteria 1MVHA@1224,2TRQC@28211,4BPUI@82117,COG0245@1,COG0245@2,COG1211@1,COG1211@2 NA|NA|NA I Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) HIMHAPGP_01926 1248916.ANFY01000007_gene2513 7e-100 370.5 Sphingomonadales gltB 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 Bacteria 1MU7B@1224,2K19P@204457,2TRHQ@28211,COG0067@1,COG0067@2,COG0069@1,COG0069@2,COG0070@1,COG0070@2 NA|NA|NA E Glutamate synthase HIMHAPGP_01929 1160718.SU9_27499 1.1e-07 64.3 Bacteria Bacteria 28Y9Y@1,2ZK4R@2 NA|NA|NA HIMHAPGP_01930 402881.Plav_2166 1.9e-28 132.1 Alphaproteobacteria GO:0003674,GO:0003824,GO:0004364,GO:0004601,GO:0004602,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0016740,GO:0016765,GO:0042221,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 Bacteria 1NBHH@1224,2UA0K@28211,COG3788@1,COG3788@2 NA|NA|NA S Membrane-associated protein in eicosanoid and glutathione metabolism HIMHAPGP_01931 1123240.ATVO01000009_gene778 9.4e-172 609.8 Sphingomonadales bioF 2.3.1.29,2.3.1.47,2.3.1.50 ko:K00639,ko:K00652,ko:K00654 ko00260,ko00600,ko00780,ko01100,ko04071,ko04138,map00260,map00600,map00780,map01100,map04071,map04138 M00094,M00099,M00123,M00573,M00577 R00371,R01281,R03210,R10124 RC00004,RC00039,RC00394,RC02725,RC02849 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 1MVVH@1224,2K0V8@204457,2TQYP@28211,COG0156@1,COG0156@2 NA|NA|NA E COG0156 7-keto-8-aminopelargonate synthetase and related enzymes HIMHAPGP_01932 1123240.ATVO01000009_gene777 7.9e-22 109.4 Sphingomonadales ko:K02078 ko00000,ko00001 Bacteria 1NHQD@1224,2K5YB@204457,2UGSG@28211,COG0236@1,COG0236@2 NA|NA|NA IQ acyl carrier protein HIMHAPGP_01933 1122132.AQYH01000016_gene2904 5.3e-09 67.4 Alphaproteobacteria Bacteria 1N72E@1224,2ETWY@1,2UIFQ@28211,33ME5@2 NA|NA|NA HIMHAPGP_01934 1234595.C725_0730 1.7e-67 263.1 Alphaproteobacteria 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 R11945 RC00061 ko00000,ko00001,ko01000 Bacteria 1RCCP@1224,2TU1D@28211,COG0702@1,COG0702@2 NA|NA|NA GM epimerase HIMHAPGP_01935 1030157.AFMP01000043_gene1678 1e-64 253.4 Sphingomonadales rsmE 2.1.1.193 ko:K09761 ko00000,ko01000,ko03009 Bacteria 1MXCU@1224,2K0TB@204457,2TS0N@28211,COG1385@1,COG1385@2 NA|NA|NA J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit HIMHAPGP_01936 1030157.AFMP01000043_gene1676 3.2e-184 651.4 Sphingomonadales gshA 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 Bacteria 1MU47@1224,2K1IW@204457,2TRPT@28211,COG3572@1,COG3572@2 NA|NA|NA H glutamate--cysteine ligase HIMHAPGP_01937 1522072.IL54_0840 5.9e-79 300.8 Sphingomonadales rlmB GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.185 ko:K03218,ko:K22132 ko00000,ko01000,ko03009,ko03016 Bacteria 1MWCM@1224,2K163@204457,2TUG7@28211,COG0566@1,COG0566@2 NA|NA|NA J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family HIMHAPGP_01938 366602.Caul_3419 2.3e-54 219.2 Caulobacterales Bacteria 1QVFN@1224,2KK70@204458,2TWDS@28211,COG2050@1,COG2050@2 NA|NA|NA Q Thioesterase-like superfamily HIMHAPGP_01939 1248760.ANFZ01000009_gene1488 3.5e-116 424.9 Sphingomonadales glpQ 3.1.4.46 ko:K01126 ko00564,map00564 R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 Bacteria 1MVWZ@1224,2K0H8@204457,2TV4M@28211,COG0584@1,COG0584@2 NA|NA|NA C glycerophosphoryl diester phosphodiesterase HIMHAPGP_01940 1095769.CAHF01000025_gene648 1.2e-74 286.6 Oxalobacteraceae yfcG ko:K11209 ko00000,ko01000 Bacteria 1MUN3@1224,2VHCD@28216,472G3@75682,COG0625@1,COG0625@2 NA|NA|NA O Belongs to the GST superfamily HIMHAPGP_01941 1211115.ALIQ01000022_gene580 4.7e-22 110.9 Beijerinckiaceae ko:K15977 ko00000 Bacteria 1MZVP@1224,2UCYS@28211,3NBUB@45404,COG2259@1,COG2259@2 NA|NA|NA S SURF4 family HIMHAPGP_01942 1346791.M529_19320 2.5e-155 555.1 Sphingomonadales ppk 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 1MUM3@1224,2K167@204457,2TRBP@28211,COG0855@1,COG0855@2 NA|NA|NA P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) HIMHAPGP_01943 1038867.AXAY01000001_gene6369 1.1e-10 71.6 Bradyrhizobiaceae ccoS Bacteria 1NG90@1224,2UJFJ@28211,3K1A3@41294,COG3197@1,COG3197@2 NA|NA|NA P Cytochrome oxidase maturation protein cbb3-type HIMHAPGP_01944 1030157.AFMP01000036_gene2551 2.4e-205 722.2 Sphingomonadales ccoI 3.6.3.4,3.6.3.54 ko:K01533,ko:K17686 ko01524,ko04016,map01524,map04016 R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 Bacteria 1MU08@1224,2K0EB@204457,2TR80@28211,COG2217@1,COG2217@2 NA|NA|NA P P-type ATPase HIMHAPGP_01945 1550073.JROH01000002_gene759 1.9e-19 102.4 Sphingomonadales fixH Bacteria 1RHKI@1224,2K623@204457,2U9GB@28211,COG5456@1,COG5456@2 NA|NA|NA P Integral membrane protein linked to a cation HIMHAPGP_01946 1030157.AFMP01000036_gene2549 1.3e-87 330.1 Sphingomonadales ccoG GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 1MVFY@1224,2K0BY@204457,2TRYB@28211,COG0348@1,COG0348@2 NA|NA|NA C Nitrogen fixation protein fixG HIMHAPGP_01948 745310.G432_14470 2.4e-234 818.5 Sphingomonadales ptrB 3.4.21.83 ko:K01354 ko05142,ko05143,map05142,map05143 ko00000,ko00001,ko01000,ko01002 Bacteria 1MUED@1224,2K19E@204457,2TTR0@28211,COG1770@1,COG1770@2 NA|NA|NA E peptidase S9 HIMHAPGP_01949 1234595.C725_2604 2.1e-84 319.3 Alphaproteobacteria iaaA 3.4.19.5,3.5.1.1 ko:K01424,ko:K13051 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 R00485 RC00010,RC02798 ko00000,ko00001,ko01000,ko01002 Bacteria 1MWFC@1224,2TU8K@28211,COG1446@1,COG1446@2 NA|NA|NA E asparaginase HIMHAPGP_01950 1123240.ATVO01000006_gene1507 1.1e-116 426.8 Sphingomonadales padH 1.18.1.3,1.2.1.58 ko:K00529,ko:K18359 ko00071,ko00360,ko01120,ko01220,map00071,map00360,map01120,map01220 M00545 R02000,R02450,R06782,R06783 RC00004,RC00098,RC02860 br01601,br01602,ko00000,ko00001,ko00002,ko01000 Bacteria 1MW58@1224,2KEE3@204457,2TW0G@28211,COG1251@1,COG1251@2 NA|NA|NA C Reductase C-terminal HIMHAPGP_01952 1248916.ANFY01000007_gene2405 3.9e-96 357.8 Sphingomonadales Bacteria 1MVCB@1224,2JZVH@204457,2TR43@28211,COG0745@1,COG0745@2 NA|NA|NA T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain HIMHAPGP_01953 1123240.ATVO01000008_gene2414 4.7e-118 431.8 Sphingomonadales Bacteria 1N17V@1224,2K1JA@204457,2TS69@28211,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor HIMHAPGP_01954 1090318.ATTI01000001_gene1907 8.9e-29 133.3 Sphingomonadales hprK GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 ko:K06023 ko00000,ko01000 Bacteria 1NNN5@1224,2K65M@204457,2UFPB@28211,COG1493@1,COG1493@2 NA|NA|NA T Serine kinase of the HPr protein, regulates carbohydrate metabolism HIMHAPGP_01955 1234595.C725_2132 7.3e-84 317.4 unclassified Alphaproteobacteria rapZ GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363 ko:K06958 ko00000,ko03019 Bacteria 1MVX6@1224,2TTI4@28211,4BQ65@82117,COG1660@1,COG1660@2 NA|NA|NA S Displays ATPase and GTPase activities HIMHAPGP_01956 1380394.JADL01000002_gene1650 4e-42 177.6 Rhodospirillales manX 2.7.1.191,2.7.1.194 ko:K02793,ko:K02794,ko:K02821 ko00051,ko00053,ko00520,ko01100,ko01120,ko02060,map00051,map00053,map00520,map01100,map01120,map02060 M00276,M00283,M00550 R02630,R07671 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.6.1,4.A.7.1 Bacteria 1RHH7@1224,2JS9V@204441,2U9E5@28211,COG2893@1,COG2893@2 NA|NA|NA G COG2893 Phosphotransferase system, mannose fructose-specific component IIA HIMHAPGP_01957 1248916.ANFY01000007_gene2401 1.7e-19 101.7 Sphingomonadales ptsO GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006808,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0009401,GO:0009987,GO:0010033,GO:0010243,GO:0016310,GO:0016740,GO:0016772,GO:0019538,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0050789,GO:0050896,GO:0051179,GO:0051234,GO:0065007,GO:0071702,GO:0071704,GO:1901564,GO:1901698 2.7.1.121 ko:K05881,ko:K08485,ko:K11189 ko00561,ko02060,map00561,map02060 R01012 RC00015,RC00017 ko00000,ko00001,ko01000,ko02000 4.A.2.1 Bacteria 1N6RM@1224,2K638@204457,2UC0H@28211,COG1925@1,COG1925@2 NA|NA|NA G COG1925 Phosphotransferase system, HPr-related proteins HIMHAPGP_01958 1030157.AFMP01000032_gene490 1.6e-58 232.3 Sphingomonadales bfr 1.16.3.1 ko:K03594 ko00860,map00860 R00078 RC02758 ko00000,ko00001,ko01000 Bacteria 1RCW7@1224,2K3XA@204457,2U70I@28211,COG2193@1,COG2193@2 NA|NA|NA P Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex HIMHAPGP_01959 745310.G432_09810 0.0 1194.9 Sphingomonadales ileS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iG2583_1286.G2583_0027,iPC815.YPO0475 Bacteria 1MVBQ@1224,2K0GR@204457,2TR3N@28211,COG0060@1,COG0060@2 NA|NA|NA J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) HIMHAPGP_01960 1123240.ATVO01000003_gene81 1.1e-41 176.4 Sphingomonadales lspA 3.4.23.36 ko:K03101 ko03060,map03060 ko00000,ko00001,ko01000,ko01002 Bacteria 1RGV9@1224,2K4K3@204457,2UBUC@28211,COG0597@1,COG0597@2 NA|NA|NA MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins HIMHAPGP_01961 1123240.ATVO01000003_gene80 2.8e-25 121.7 Sphingomonadales Bacteria 1RG08@1224,2C068@1,2KCIE@204457,2UH97@28211,30N9J@2 NA|NA|NA S Protein of unknown function (DUF3035) HIMHAPGP_01962 1174684.EBMC1_05764 5.1e-183 647.5 Sphingomonadales yjgR ko:K06915,ko:K19172 ko00000,ko02048 Bacteria 1MU59@1224,2JZYW@204457,2TRU8@28211,COG0433@1,COG0433@2 NA|NA|NA S Bacterial protein of unknown function (DUF853) HIMHAPGP_01964 118168.MC7420_7594 5.2e-11 74.7 Oscillatoriales Bacteria 1GF0W@1117,1HGPW@1150,2FE4C@1,3464A@2 NA|NA|NA HIMHAPGP_01965 1248916.ANFY01000007_gene2606 3.4e-30 137.9 Sphingomonadales dop GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 Bacteria 1MU63@1224,2K08H@204457,2TQPZ@28211,COG0265@1,COG0265@2 NA|NA|NA M Belongs to the peptidase S1C family HIMHAPGP_01967 1123269.NX02_28610 2.1e-71 275.8 Sphingomonadales Bacteria 1MUUV@1224,2K33T@204457,2TR0A@28211,COG1028@1,COG1028@2 NA|NA|NA IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) HIMHAPGP_01968 1248916.ANFY01000005_gene2868 8.5e-29 133.3 Sphingomonadales folB 1.13.11.81,4.1.2.25,5.1.99.8 ko:K01633 ko00790,ko01100,map00790,map01100 M00126,M00840 R03504,R11037,R11073 RC00721,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 Bacteria 1PSIE@1224,2K4H4@204457,2UD0R@28211,COG1539@1,COG1539@2 NA|NA|NA H dihydroneopterin aldolase HIMHAPGP_01969 1248916.ANFY01000005_gene2869 5.7e-25 121.3 Sphingomonadales Bacteria 1RA7X@1224,2CJQX@1,2KDDU@204457,2U5C1@28211,342E0@2 NA|NA|NA HIMHAPGP_01970 1123240.ATVO01000003_gene37 2.5e-33 149.1 Sphingomonadales tonB ko:K03832 ko00000,ko02000 2.C.1.1 Bacteria 1RCAG@1224,2K187@204457,2U664@28211,COG0810@1,COG0810@2 NA|NA|NA M Periplasmic protein TonB, links inner and outer membranes HIMHAPGP_01971 1123240.ATVO01000003_gene38 1.7e-75 289.3 Sphingomonadales exbB ko:K03561,ko:K03562 ko01120,map01120 ko00000,ko02000 1.A.30.2.1,1.A.30.2.2 Bacteria 1NMPB@1224,2K1P2@204457,2TS4F@28211,COG0811@1,COG0811@2 NA|NA|NA U MotA TolQ ExbB proton channel HIMHAPGP_01972 1123240.ATVO01000003_gene39 1.5e-45 189.1 Sphingomonadales exbD1 ko:K03559 ko00000,ko02000 1.A.30.2.1 Bacteria 1RH4U@1224,2K4K9@204457,2UAMQ@28211,COG0848@1,COG0848@2 NA|NA|NA U Biopolymer HIMHAPGP_01973 1248916.ANFY01000013_gene1925 1e-43 183.0 Sphingomonadales exbD2 ko:K03559 ko00000,ko02000 1.A.30.2.1 Bacteria 1RHDF@1224,2K55Z@204457,2UEA0@28211,COG0848@1,COG0848@2 NA|NA|NA U Biopolymer transport protein HIMHAPGP_01974 1331060.RLDS_22630 2.2e-46 191.4 Sphingomonadales hypE ko:K04655,ko:K08303 ko05120,map05120 ko00000,ko00001,ko01000,ko01002 Bacteria 1N4H8@1224,2K7M6@204457,2UDVZ@28211,COG0309@1,COG0309@2 NA|NA|NA O Transposase DDE domain HIMHAPGP_01975 1331060.RLDS_22625 8.5e-56 223.0 Sphingomonadales Bacteria 1RDDI@1224,2K6GM@204457,2UAE0@28211,COG3293@1,COG3293@2 NA|NA|NA L COG3293 Transposase and inactivated derivatives HIMHAPGP_01976 1234595.C725_2497 3e-209 734.9 unclassified Alphaproteobacteria msbA ko:K06147,ko:K11085 ko02010,map02010 ko00000,ko00001,ko01000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 1MUBM@1224,2TQMR@28211,4BPW2@82117,COG1132@1,COG1132@2 NA|NA|NA V ABC transporter transmembrane region HIMHAPGP_01977 317655.Sala_1970 1.1e-57 229.9 Sphingomonadales Bacteria 1R52Z@1224,28JRZ@1,2K3XN@204457,2U6D6@28211,2Z9HI@2 NA|NA|NA S Domain of unknown function (DUF4126) HIMHAPGP_01978 1123240.ATVO01000007_gene2251 1.1e-226 792.3 Sphingomonadales MA20_16360 1.3.8.1,1.3.8.7 ko:K00248,ko:K00249 ko00071,ko00280,ko00410,ko00640,ko00650,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map00650,map01100,map01110,map01120,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01178,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00120,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 Bacteria 1MWUU@1224,2K2YK@204457,2TT47@28211,COG1960@1,COG1960@2 NA|NA|NA I Acyl-CoA dehydrogenase, C-terminal domain HIMHAPGP_01979 1248916.ANFY01000003_gene464 3.4e-96 357.8 Sphingomonadales asd 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 iLJ478.TM1523 Bacteria 1MUHG@1224,2K104@204457,2TSRD@28211,COG0136@1,COG0136@2 NA|NA|NA E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate HIMHAPGP_01980 1123240.ATVO01000005_gene2001 4.2e-71 274.2 Sphingomonadales infC GO:0000049,GO:0001731,GO:0002181,GO:0002183,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006417,GO:0006446,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016020,GO:0016043,GO:0019222,GO:0019538,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032268,GO:0032270,GO:0032790,GO:0032984,GO:0032988,GO:0032991,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043254,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045727,GO:0045948,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065003,GO:0065007,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901193,GO:1901195,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:1904688,GO:1904690,GO:1990856,GO:1990904,GO:2000112,GO:2000765,GO:2000767 ko:K02520 ko00000,ko03012,ko03029 Bacteria 1RDD2@1224,2K0EN@204457,2U58Z@28211,COG0290@1,COG0290@2 NA|NA|NA J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins HIMHAPGP_01981 1123269.NX02_10710 2.6e-223 781.2 Sphingomonadales bhbA 5.4.99.2 ko:K01847 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUXX@1224,2K0E7@204457,2TQYC@28211,COG1884@1,COG1884@2,COG2185@1,COG2185@2 NA|NA|NA I Methylmalonyl-CoA mutase HIMHAPGP_01982 331869.BAL199_12631 3.3e-69 268.1 unclassified Alphaproteobacteria Bacteria 1MU5Y@1224,2TRNQ@28211,4BPG6@82117,COG1028@1,COG1028@2 NA|NA|NA IQ Enoyl-(Acyl carrier protein) reductase HIMHAPGP_01983 1248916.ANFY01000003_gene1025 6.8e-138 497.3 Sphingomonadales 2.1.1.317,2.1.1.79 ko:K00574,ko:K20238 ko00000,ko01000 Bacteria 1MX3U@1224,2K0PR@204457,2TR8K@28211,COG2230@1,COG2230@2 NA|NA|NA M synthase HIMHAPGP_01984 1144305.PMI02_04282 5.4e-215 753.8 Sphingomonadales MA20_01895 Bacteria 1MV2R@1224,2JZXX@204457,2TSR0@28211,COG1233@1,COG1233@2 NA|NA|NA Q Oxidoreductase HIMHAPGP_01985 1545915.JROG01000009_gene2818 2.5e-59 235.3 Sphingomonadales Bacteria 1RANW@1224,2K411@204457,2U66N@28211,COG0500@1,COG2226@2 NA|NA|NA Q ubiE/COQ5 methyltransferase family HIMHAPGP_01986 745310.G432_06425 1.2e-193 683.7 Sphingomonadales ko:K02014 ko00000,ko02000 1.B.14 Bacteria 1MXFM@1224,2K14T@204457,2TWYV@28211,COG4206@1,COG4206@2 NA|NA|NA H Outer membrane receptor proteins, mostly Fe transport HIMHAPGP_01987 452662.SJA_C1-28320 1.4e-185 656.0 Sphingomonadales ko:K07110,ko:K21686,ko:K22300 ko00000,ko03000 Bacteria 1MU50@1224,2K126@204457,2TRKE@28211,COG1396@1,COG1396@2,COG3800@1,COG3800@2 NA|NA|NA K Transcriptional regulator HIMHAPGP_01988 1123267.JONN01000001_gene2239 1.4e-83 316.2 Sphingomonadales gyrB GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 ko:K02470 ko00000,ko01000,ko03032,ko03400 Bacteria 1MVKT@1224,2K0E4@204457,2TRBK@28211,COG0187@1,COG0187@2 NA|NA|NA L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner HIMHAPGP_01990 1030157.AFMP01000052_gene182 3.7e-20 106.3 Sphingomonadales gspL ko:K02461 ko03070,ko05111,map03070,map05111 M00331 ko00000,ko00001,ko00002,ko02044 3.A.15 Bacteria 1N0FQ@1224,2K35M@204457,2UEET@28211,COG3297@1,COG3297@2 NA|NA|NA U Type II secretion system (T2SS), protein L HIMHAPGP_01991 1522072.IL54_4459 1.9e-23 116.7 Sphingomonadales gspK GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 ko:K02460 ko03070,ko05111,map03070,map05111 M00331 ko00000,ko00001,ko00002,ko02044 3.A.15 Bacteria 1RAQM@1224,2K0PH@204457,2U6QZ@28211,COG3156@1,COG3156@2 NA|NA|NA U Type II secretion system protein K HIMHAPGP_01992 1537715.JQFJ01000005_gene215 3.5e-20 105.1 Sphingomonadales gspJ GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0098776 ko:K02459 ko03070,ko05111,map03070,map05111 M00331 ko00000,ko00001,ko00002,ko02044 3.A.15 Bacteria 1N942@1224,2K78E@204457,2UGPF@28211,COG4795@1,COG4795@2 NA|NA|NA U Type II secretion system (T2SS), protein J HIMHAPGP_01994 745310.G432_00325 5.8e-31 140.6 Sphingomonadales gspG GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 ko:K02246,ko:K02456 ko03070,ko05111,map03070,map05111 M00331,M00429 ko00000,ko00001,ko00002,ko02044 3.A.15 Bacteria 1RDX2@1224,2K4TG@204457,2U8VA@28211,COG2165@1,COG2165@2 NA|NA|NA NU general secretion pathway protein G HIMHAPGP_01995 1123269.NX02_12910 2e-55 223.0 Sphingomonadales gspF ko:K02455,ko:K02653 ko03070,ko05111,map03070,map05111 M00331 ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 Bacteria 1MV4U@1224,2K0ZH@204457,2TV76@28211,COG1459@1,COG1459@2 NA|NA|NA U General secretion pathway protein F HIMHAPGP_01996 745310.G432_02475 3.5e-27 128.3 Sphingomonadales ko:K09796 ko00000,ko03110 Bacteria 1N3BG@1224,2K60Y@204457,2UM57@28211,COG2847@1,COG2847@2 NA|NA|NA S Copper chaperone PCu(A)C HIMHAPGP_01997 1081640.AGFU01000067_gene3669 2e-39 168.7 Sphingomonadales ko:K11904 ko03070,map03070 M00334 ko00000,ko00001,ko00002,ko02044 3.A.23.1 Bacteria 1RJSI@1224,2K54I@204457,2UAVI@28211,COG4253@1,COG4253@2 NA|NA|NA HIMHAPGP_01998 237727.NAP1_02205 9.5e-12 76.3 Sphingomonadales GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042594,GO:0050896,GO:0051716,GO:0071496 Bacteria 1N8V7@1224,2K761@204457,2UFYD@28211,COG1359@1,COG1359@2 NA|NA|NA S Antibiotic biosynthesis monooxygenase HIMHAPGP_01999 1502850.FG91_00430 2.7e-38 165.2 Sphingomonadales grpE GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0007154,GO:0008150,GO:0009266,GO:0009267,GO:0009408,GO:0009605,GO:0009628,GO:0009986,GO:0009987,GO:0009991,GO:0016043,GO:0017076,GO:0019904,GO:0022607,GO:0030234,GO:0030246,GO:0030247,GO:0030312,GO:0030554,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0033554,GO:0036094,GO:0040007,GO:0042594,GO:0042802,GO:0042803,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0050790,GO:0050896,GO:0051082,GO:0051716,GO:0060589,GO:0060590,GO:0065003,GO:0065007,GO:0065009,GO:0071496,GO:0071840,GO:0071944,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065 ko:K03687 ko00000,ko03029,ko03110 Bacteria 1RH8T@1224,2K3XC@204457,2U5V2@28211,COG0576@1,COG0576@2 NA|NA|NA O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HIMHAPGP_02000 745310.G432_07055 7e-115 420.6 Sphingomonadales hrcA GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 ko:K03705 ko00000,ko03000 Bacteria 1MVX4@1224,2K03N@204457,2TRUF@28211,COG1420@1,COG1420@2 NA|NA|NA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons HIMHAPGP_02001 1123240.ATVO01000005_gene1927 3.9e-101 374.4 Sphingomonadales rph GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006401,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043170,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:1901361,GO:1901575 2.7.7.56,3.6.1.66 ko:K00989,ko:K02428 ko00230,map00230 R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000,ko03016 Bacteria 1MVFZ@1224,2K0PW@204457,2TRMC@28211,COG0689@1,COG0689@2 NA|NA|NA J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates HIMHAPGP_02002 1112216.JH594425_gene2269 7.8e-69 266.9 Sphingomonadales rdgB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66,5.1.1.3 ko:K01776,ko:K02428 ko00230,ko00471,ko01100,map00230,map00471,map01100 R00260,R00426,R00720,R01855,R02100,R02720,R03531 RC00002,RC00302 ko00000,ko00001,ko01000,ko01011 Bacteria 1MUK5@1224,2K1NS@204457,2TV4B@28211,COG0127@1,COG0127@2 NA|NA|NA F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions HIMHAPGP_02003 1090318.ATTI01000001_gene3064 1.2e-126 459.9 Sphingomonadales yggW GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 Bacteria 1MU76@1224,2K09I@204457,2TT63@28211,COG0635@1,COG0635@2 NA|NA|NA H Involved in the biosynthesis of porphyrin-containing compound HIMHAPGP_02005 1090318.ATTI01000001_gene2119 3.1e-28 131.3 Sphingomonadales ybaN ko:K09790 ko00000 Bacteria 1N7BI@1224,2K6I4@204457,2UFAC@28211,COG2832@1,COG2832@2 NA|NA|NA S Protein of unknown function (DUF454) HIMHAPGP_02006 450851.PHZ_c1089 0.0 1359.4 Caulobacterales Bacteria 1MX3A@1224,2KG4I@204458,2TUU6@28211,COG0823@1,COG0823@2,COG1228@1,COG1228@2 NA|NA|NA QU Amidohydrolase family HIMHAPGP_02007 13689.BV96_03644 1.1e-91 342.8 Sphingomonadales scoB 2.8.3.5 ko:K01027,ko:K01029 ko00072,ko00280,ko00650,map00072,map00280,map00650 R00410 RC00014 ko00000,ko00001,ko01000 Bacteria 1RA4V@1224,2JZXA@204457,2TQS5@28211,COG2057@1,COG2057@2 NA|NA|NA I Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit HIMHAPGP_02008 194867.ALBQ01000011_gene40 9.6e-44 184.1 Sphingomonadales hel GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 Bacteria 1RB4N@1224,2K2HX@204457,2U6AV@28211,COG2503@1,COG2503@2 NA|NA|NA S HAD superfamily, subfamily IIIB (Acid phosphatase) HIMHAPGP_02009 1248916.ANFY01000003_gene467 6.9e-106 390.2 Sphingomonadales scoA 2.8.3.5 ko:K01027,ko:K01028 ko00072,ko00280,ko00650,map00072,map00280,map00650 R00410 RC00014 ko00000,ko00001,ko01000 Bacteria 1MVEI@1224,2K0EF@204457,2TTE6@28211,COG1788@1,COG1788@2 NA|NA|NA I Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit HIMHAPGP_02010 1123240.ATVO01000008_gene2328 2.7e-53 215.3 Sphingomonadales gpmB Bacteria 1RG9K@1224,2K1EM@204457,2U8NV@28211,COG0406@1,COG0406@2 NA|NA|NA G Histidine phosphatase superfamily (branch 1) HIMHAPGP_02011 1122970.AUHC01000019_gene2093 1.2e-94 352.8 Sphingomonadales Bacteria 1RFVJ@1224,2BFHU@1,2K1CV@204457,2U8MF@28211,329BM@2 NA|NA|NA HIMHAPGP_02012 1121124.JNIX01000005_gene1301 3.9e-93 347.8 Caulobacterales Bacteria 1R6YG@1224,28PH0@1,2KI89@204458,2U2A9@28211,2ZC7M@2 NA|NA|NA HIMHAPGP_02013 317655.Sala_3052 8.3e-40 169.9 Sphingomonadales Bacteria 1RH61@1224,2K689@204457,2UAE3@28211,COG0251@1,COG0251@2 NA|NA|NA J Endoribonuclease L-PSP HIMHAPGP_02015 1265313.HRUBRA_02029 2.5e-117 429.1 Gammaproteobacteria ko:K01138 ko00000,ko01000 Bacteria 1MV92@1224,1RPM3@1236,COG3119@1,COG3119@2 NA|NA|NA P COG3119 Arylsulfatase A and related enzymes HIMHAPGP_02016 1163408.UU9_05624 7e-67 260.8 Gammaproteobacteria yut GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0009987,GO:0015204,GO:0015265,GO:0015267,GO:0015840,GO:0016020,GO:0016043,GO:0019755,GO:0022607,GO:0022803,GO:0022838,GO:0022857,GO:0031224,GO:0031226,GO:0033218,GO:0033219,GO:0036094,GO:0042802,GO:0042886,GO:0042887,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0070206,GO:0070207,GO:0071702,GO:0071705,GO:0071840,GO:0071918,GO:0071944 ko:K08717 ko00000,ko02000 1.A.28.2 Bacteria 1N2FW@1224,1T0IP@1236,COG4413@1,COG4413@2 NA|NA|NA E Urea transporter HIMHAPGP_02017 1234595.C725_1201 5.5e-143 514.6 Alphaproteobacteria Bacteria 1MVET@1224,2TVHW@28211,COG3182@1,COG3182@2 NA|NA|NA IQ iron-regulated membrane protein HIMHAPGP_02018 1123367.C666_03735 1.6e-16 92.0 Betaproteobacteria Bacteria 1N7FK@1224,2DNP1@1,2VWPH@28216,32YDC@2 NA|NA|NA HIMHAPGP_02020 1280952.HJA_03171 3.5e-45 188.7 Alphaproteobacteria ko:K07017 ko00000 Bacteria 1RB1X@1224,2TVVR@28211,COG2819@1,COG2819@2 NA|NA|NA S Putative esterase HIMHAPGP_02021 13690.CP98_01368 1e-235 823.2 Sphingomonadales ko:K02014 ko00000,ko02000 1.B.14 Bacteria 1QTT0@1224,2K1ZF@204457,2TQSQ@28211,COG4773@1,COG4773@2 NA|NA|NA P TonB-dependent siderophore receptor HIMHAPGP_02022 228410.NE2303 1.6e-171 609.4 Nitrosomonadales hcaD 1.18.1.1,1.7.1.15 ko:K00362,ko:K05297,ko:K05710 ko00071,ko00360,ko00910,ko01120,ko01220,map00071,map00360,map00910,map01120,map01220 M00530,M00545 R00787,R02000,R06782,R06783 RC00098,RC00176 br01602,ko00000,ko00001,ko00002,ko01000 Bacteria 1NR3M@1224,2VJSV@28216,372DS@32003,COG0446@1,COG0446@2,COG2146@1,COG2146@2 NA|NA|NA C Pyridine nucleotide-disulphide oxidoreductase HIMHAPGP_02025 1134912.AJTV01000010_gene637 4.4e-38 163.7 Methylocystaceae metK GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUFQ@1224,2TR4P@28211,36XNU@31993,COG0192@1,COG0192@2 NA|NA|NA H S-adenosylmethionine synthetase, C-terminal domain HIMHAPGP_02027 1123240.ATVO01000005_gene1953 7.3e-124 450.3 Sphingomonadales argB GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0030312,GO:0031406,GO:0034618,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS10565,iJN678.argB,iLJ478.TM1784 Bacteria 1MU17@1224,2K107@204457,2TQQS@28211,COG0548@1,COG0548@2 NA|NA|NA E Belongs to the acetylglutamate kinase family. ArgB subfamily HIMHAPGP_02028 392499.Swit_3216 1.6e-75 289.3 Sphingomonadales lexA GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031668,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 3.4.21.88 ko:K01356 M00729 ko00000,ko00002,ko01000,ko01002,ko03400 Bacteria 1MW80@1224,2K1AX@204457,2TT7W@28211,COG1974@1,COG1974@2 NA|NA|NA K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair HIMHAPGP_02029 1123240.ATVO01000006_gene1301 9.4e-100 370.5 Sphingomonadales moeA 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 R09735 RC03462 ko00000,ko00001,ko01000 Bacteria 1MVD5@1224,2K1RP@204457,2TQRI@28211,COG0303@1,COG0303@2 NA|NA|NA H molybdopterin biosynthesis HIMHAPGP_02030 1120705.FG95_02858 4.4e-48 197.6 Sphingomonadales moaC 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 R11372 RC03425 ko00000,ko00001,ko01000 Bacteria 1RCYZ@1224,2K4GG@204457,2U747@28211,COG0315@1,COG0315@2 NA|NA|NA H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) HIMHAPGP_02031 745310.G432_02760 3.7e-76 291.6 Sphingomonadales trpC GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831 4.1.1.48,5.3.1.24 ko:K01609,ko:K13498 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508,R03509 RC00944,RC00945 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2494 Bacteria 1MW5K@1224,2K0PS@204457,2TSZE@28211,COG0134@1,COG0134@2 NA|NA|NA E Belongs to the TrpC family HIMHAPGP_02032 1123240.ATVO01000006_gene1298 5.5e-77 294.7 Sphingomonadales trpD GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 ko:K00766,ko:K13497 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R00985,R00986,R01073 RC00010,RC00440,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUPV@1224,2K11A@204457,2TR8S@28211,COG0547@1,COG0547@2 NA|NA|NA E Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) HIMHAPGP_02033 402881.Plav_3171 1.7e-64 252.3 Rhodobiaceae trpG 2.4.2.18,2.6.1.85,4.1.3.27 ko:K01658,ko:K01664,ko:K13497 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01073,R01716 RC00010,RC00440,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 Bacteria 1JNTB@119043,1MV5Y@1224,2TU3N@28211,COG0512@1,COG0512@2 NA|NA|NA EH Peptidase C26 HIMHAPGP_02034 1123503.KB908057_gene2502 4.9e-137 494.6 Caulobacterales Bacteria 1RI0Y@1224,2KIGE@204458,2UAAY@28211,COG0673@1,COG0673@2 NA|NA|NA S Oxidoreductase family, NAD-binding Rossmann fold HIMHAPGP_02035 1123267.JONN01000001_gene2210 4.9e-79 300.8 Sphingomonadales ftsK ko:K03466 ko00000,ko03036 3.A.12 Bacteria 1MVPI@1224,2K02P@204457,2TR48@28211,COG1674@1,COG1674@2 NA|NA|NA D DNA segregation ATPase FtsK SpoIIIE HIMHAPGP_02038 1234595.C725_0137 7.3e-206 723.4 Alphaproteobacteria ko:K03446 M00701 ko00000,ko00002,ko02000 2.A.1.3 Bacteria 1MU1I@1224,2TVXT@28211,COG0477@1,COG2814@2 NA|NA|NA EGP Major facilitator Superfamily HIMHAPGP_02039 1123240.ATVO01000005_gene1973 4e-136 491.1 Sphingomonadales ko:K07119 ko00000 Bacteria 1MUC2@1224,2K21X@204457,2TQYM@28211,COG2130@1,COG2130@2 NA|NA|NA L alcohol dehydrogenase HIMHAPGP_02040 1549858.MC45_13725 2.9e-83 315.5 Sphingomonadales yedI GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K09781 ko00000 Bacteria 1MVYU@1224,2K0C1@204457,2TU43@28211,COG2354@1,COG2354@2 NA|NA|NA S protein conserved in bacteria HIMHAPGP_02041 1550073.JROH01000036_gene2641 4.8e-52 210.7 Sphingomonadales rnhA GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 ko:K03469 ko03030,map03030 ko00000,ko00001,ko01000,ko03032 Bacteria 1RCZ1@1224,2K3YC@204457,2U7C4@28211,COG0328@1,COG0328@2 NA|NA|NA L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids HIMHAPGP_02042 1248916.ANFY01000011_gene1133 1.4e-93 349.7 Sphingomonadales thrB 2.7.1.39 ko:K02204 ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 M00018 R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUKJ@1224,2K09Q@204457,2TS6D@28211,COG2334@1,COG2334@2 NA|NA|NA F Belongs to the pseudomonas-type ThrB family HIMHAPGP_02043 1248916.ANFY01000011_gene1132 8.8e-125 453.4 Sphingomonadales ispH 1.17.7.4,2.7.4.25 ko:K00945,ko:K02945,ko:K03527 ko00240,ko00900,ko01100,ko01110,ko01130,ko03010,map00240,map00900,map01100,map01110,map01130,map03010 M00052,M00096,M00178 R00158,R00512,R01665,R05884,R08210 RC00002,RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko03011 iIT341.HP0400,iLJ478.TM1444 Bacteria 1MU7G@1224,2K1ES@204457,2TRNR@28211,COG0761@1,COG0761@2 NA|NA|NA IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis HIMHAPGP_02044 1234595.C725_1140 7.2e-46 190.7 Alphaproteobacteria Bacteria 1RJ6S@1224,28PM9@1,2UAN3@28211,2ZCAC@2 NA|NA|NA HIMHAPGP_02047 1030157.AFMP01000044_gene1812 2.2e-42 179.1 Sphingomonadales Bacteria 1N97M@1224,2K4JZ@204457,2UF88@28211,COG2932@1,COG2932@2 NA|NA|NA K Transcriptional regulator HIMHAPGP_02048 452662.SJA_C1-07510 5.9e-09 66.6 Sphingomonadales Bacteria 1NPK2@1224,2BMMB@1,2K7TJ@204457,2UKR9@28211,32G6F@2 NA|NA|NA HIMHAPGP_02050 1248916.ANFY01000005_gene2705 7.4e-59 234.6 Sphingomonadales ko:K18302 M00642 ko00000,ko00002,ko01504,ko02000 2.A.6.2,8.A.1 Bacteria 1NJDF@1224,2K42V@204457,2TSZA@28211,COG0845@1,COG0845@2 NA|NA|NA M Barrel-sandwich domain of CusB or HlyD membrane-fusion HIMHAPGP_02054 1123269.NX02_18880 0.0 1201.4 Sphingomonadales ko:K02014 ko00000,ko02000 1.B.14 Bacteria 1MVFB@1224,2KEFU@204457,2U0N7@28211,COG1629@1,COG4771@2 NA|NA|NA P TonB-dependent receptor plug HIMHAPGP_02055 1288494.EBAPG3_20000 1.1e-12 79.7 Nitrosomonadales fliR ko:K02421 ko02040,map02040 ko00000,ko00001,ko02035,ko02044 3.A.6.2 Bacteria 1NIF4@1224,2VQ64@28216,37217@32003,COG1684@1,COG1684@2 NA|NA|NA N Role in flagellar biosynthesis HIMHAPGP_02056 1030157.AFMP01000040_gene1351 5.7e-70 271.6 Sphingomonadales flhB ko:K02401,ko:K02556,ko:K03229,ko:K04061,ko:K13820 ko02020,ko02030,ko02040,ko03070,map02020,map02030,map02040,map03070 M00332,M00542,M00660 ko00000,ko00001,ko00002,ko02000,ko02035,ko02044 1.A.30.1,3.A.6.1,3.A.6.2,3.A.6.3 Bacteria 1MUWI@1224,2K0RR@204457,2TS13@28211,COG1377@1,COG1377@2 NA|NA|NA N Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin HIMHAPGP_02057 1248916.ANFY01000009_gene113 2.2e-63 250.0 Sphingomonadales amiC 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 Bacteria 1MUQK@1224,2K2BU@204457,2U0K2@28211,COG0860@1,COG0860@2 NA|NA|NA M N-acetylmuramoyl-L-alanine amidase HIMHAPGP_02058 1234595.C725_0780 1.8e-42 179.5 Bacteria Bacteria COG1309@1,COG1309@2 NA|NA|NA K transcriptional regulator HIMHAPGP_02059 1449076.JOOE01000001_gene2402 1.2e-80 306.6 Sphingomonadales Bacteria 1MVVX@1224,2K14Q@204457,2TT0S@28211,COG0596@1,COG0596@2 NA|NA|NA S Alpha beta hydrolase HIMHAPGP_02060 301.JNHE01000015_gene4375 1.2e-178 632.9 Pseudomonas aeruginosa group gabD 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 Bacteria 1MU1V@1224,1RMBQ@1236,1YDZ3@136841,COG1012@1,COG1012@2 NA|NA|NA C Catalyzes the formation of succinate from succinate semialdehyde HIMHAPGP_02061 629773.AORY01000004_gene639 1.9e-83 315.8 Sphingomonadales tatC GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 ko:K03118 ko03060,ko03070,map03060,map03070 M00336 ko00000,ko00001,ko00002,ko02044 2.A.64 Bacteria 1MVAY@1224,2K1PD@204457,2TTIX@28211,COG0805@1,COG0805@2 NA|NA|NA U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides HIMHAPGP_02062 745310.G432_05470 1e-22 112.8 Sphingomonadales tatB GO:0003674,GO:0005215 ko:K03116,ko:K03117 ko03060,ko03070,map03060,map03070 M00336 ko00000,ko00001,ko00002,ko02044 2.A.64 Bacteria 1N73F@1224,2K60Q@204457,2UF4Z@28211,COG1826@1,COG1826@2 NA|NA|NA U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation HIMHAPGP_02063 438753.AZC_1736 2.5e-15 87.8 Xanthobacteraceae tatA ko:K03116 ko03060,ko03070,map03060,map03070 M00336 ko00000,ko00001,ko00002,ko02044 2.A.64 Bacteria 1NGDP@1224,2UFBN@28211,3F01R@335928,COG1826@1,COG1826@2 NA|NA|NA U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system HIMHAPGP_02064 1123267.JONN01000001_gene1695 1.6e-60 239.2 Sphingomonadales scpB ko:K06024 ko00000,ko03036 Bacteria 1PUA6@1224,2K231@204457,2TU64@28211,COG1386@1,COG1386@2 NA|NA|NA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves HIMHAPGP_02065 1090320.KB900605_gene585 2.1e-148 531.9 Sphingomonadales prfB GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02836 ko00000,ko03012 Bacteria 1MUAW@1224,2K0B2@204457,2TR9V@28211,COG1186@1,COG1186@2 NA|NA|NA J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA HIMHAPGP_02066 627192.SLG_13400 2e-165 589.0 Sphingomonadales dtpT ko:K03305 ko00000 2.A.17 Bacteria 1MW6W@1224,2K2WX@204457,2U15C@28211,COG3104@1,COG3104@2 NA|NA|NA E amino acid peptide transporter HIMHAPGP_02067 1123269.NX02_22390 5e-260 904.0 Sphingomonadales mrcA GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 ko00000,ko00001,ko01000,ko01003,ko01011 GT51 Bacteria 1MU5A@1224,2K0P9@204457,2USBB@28211,COG5009@1,COG5009@2 NA|NA|NA M Penicillin-binding Protein HIMHAPGP_02068 1522072.IL54_2666 1.1e-54 219.5 Sphingomonadales MA20_21090 Bacteria 1RA93@1224,2K40E@204457,2U741@28211,COG5328@1,COG5328@2 NA|NA|NA S Belongs to the UPF0262 family HIMHAPGP_02069 1449076.JOOE01000001_gene2426 6.8e-93 346.7 Sphingomonadales dcd GO:0003674,GO:0003824,GO:0006139,GO:0006220,GO:0006244,GO:0006253,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008829,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009166,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009223,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046065,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.5.4.13 ko:K01494 ko00240,ko01100,map00240,map01100 M00053 R00568,R02325 RC00074 ko00000,ko00001,ko00002,ko01000 Bacteria 1MV2J@1224,2JZVF@204457,2TSDM@28211,COG0717@1,COG0717@2 NA|NA|NA F Belongs to the dCTP deaminase family HIMHAPGP_02070 1090318.ATTI01000001_gene1160 6.3e-63 247.7 Sphingomonadales Bacteria 1R6C4@1224,2K0HN@204457,2UAG0@28211,COG1215@1,COG1215@2 NA|NA|NA M Glycosyl transferase family 2 HIMHAPGP_02071 1188256.BASI01000002_gene3522 9.7e-22 109.4 Rhodovulum MA20_22095 ko:K12979 ko00000,ko01000,ko01005 Bacteria 1MZEQ@1224,2UBR3@28211,3FDF6@34008,COG3502@1,COG3502@2 NA|NA|NA S Protein of unknown function (DUF952) HIMHAPGP_02073 1500890.JQNL01000001_gene3863 2.8e-07 63.9 Xanthomonadales plyA3 ko:K12547 ko00000 Bacteria 1R1U6@1224,1T5B3@1236,1XAEB@135614,COG5434@1,COG5434@2 NA|NA|NA M Right handed beta helix region HIMHAPGP_02074 1248916.ANFY01000011_gene1157 1.3e-63 249.6 Sphingomonadales MA20_22970 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 Bacteria 1PA0Q@1224,2K4XA@204457,2TVIC@28211,COG0625@1,COG0625@2 NA|NA|NA O Glutathione S-transferase, N-terminal domain HIMHAPGP_02075 317655.Sala_0499 3.3e-175 621.3 Sphingomonadales murA GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008760,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016765,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 R00660 RC00350 ko00000,ko00001,ko01000,ko01011 Bacteria 1MUH7@1224,2K1H1@204457,2TRPH@28211,COG0766@1,COG0766@2 NA|NA|NA M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine HIMHAPGP_02076 1121123.AUAO01000001_gene658 1.6e-17 95.9 Caulobacterales MA20_21100 Bacteria 1N1FB@1224,2CN5Z@1,2KH23@204458,2UBV1@28211,32SGB@2 NA|NA|NA S Protein of unknown function (DUF2948) HIMHAPGP_02077 59538.XP_005973555.1 5e-183 647.9 Bilateria Metazoa 2RJJX@2759,39GFR@33154,3BD5Y@33208,3DD5K@33213,COG2015@1 NA|NA|NA Q Alkyl sulfatase dimerisation HIMHAPGP_02078 1112214.AHIS01000083_gene3608 4.4e-87 328.6 Sphingomonadales 1.14.14.12 ko:K16047 ko00984,ko01100,ko01120,map00984,map01100,map01120 R09819 RC00236 ko00000,ko00001,ko01000 Bacteria 1MXMQ@1224,2K5X9@204457,2TTF6@28211,COG1960@1,COG1960@2 NA|NA|NA I Acyl-CoA dehydrogenase, C-terminal domain HIMHAPGP_02079 1502850.FG91_01487 2e-159 569.7 Proteobacteria Bacteria 1MWKN@1224,COG1629@1,COG4771@2 NA|NA|NA P COG1629 Outer membrane receptor proteins, mostly Fe transport HIMHAPGP_02080 1502850.FG91_01488 3.4e-159 568.5 Sphingomonadales 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 Bacteria 1MV0B@1224,2KB25@204457,2TRI6@28211,COG3119@1,COG3119@2 NA|NA|NA P Sulfatase HIMHAPGP_02081 743721.Psesu_0358 8.2e-24 116.7 Xanthomonadales Bacteria 1QB3J@1224,1T6ME@1236,1X7S1@135614,COG3094@1,COG3094@2 NA|NA|NA S Invasion gene expression up-regulator, SirB HIMHAPGP_02082 392499.Swit_5200 0.0 1265.4 Sphingomonadales norB 1.7.2.5 ko:K04561 ko00910,ko01120,map00910,map01120 M00529 R00294 RC02794 ko00000,ko00001,ko00002,ko01000 3.D.4.10 Bacteria 1MVT1@1224,2K2ZX@204457,2TUJ1@28211,COG3256@1,COG3256@2 NA|NA|NA P Nitric oxide reductase HIMHAPGP_02083 1088721.NSU_4737 8.3e-52 209.9 Sphingomonadales Bacteria 1RHUE@1224,2AH4X@1,2K4IK@204457,2UADH@28211,317EK@2 NA|NA|NA HIMHAPGP_02084 13689.BV96_04645 1.8e-114 419.5 Sphingomonadales ko:K07234 ko00000 Bacteria 1MUJK@1224,2K1GY@204457,2TSQ2@28211,COG3213@1,COG3213@2 NA|NA|NA P NnrS protein HIMHAPGP_02085 1502850.FG91_00847 7e-154 550.4 Sphingomonadales Bacteria 1MVID@1224,2K09V@204457,2TUR0@28211,COG1301@1,COG1301@2 NA|NA|NA C Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family HIMHAPGP_02088 450851.PHZ_c1904 3.5e-92 345.5 Caulobacterales Bacteria 1MUAK@1224,2KEYY@204458,2TSUC@28211,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor HIMHAPGP_02089 1123269.NX02_04720 1.2e-260 905.6 Sphingomonadales yjjK GO:0003674,GO:0003824,GO:0005488,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:2000112,GO:2000113 3.6.3.25 ko:K06020 ko00000,ko01000 Bacteria 1MU37@1224,2K0YK@204457,2TS7G@28211,COG0488@1,COG0488@2 NA|NA|NA S ABC transporter HIMHAPGP_02090 745310.G432_13795 1.1e-12 80.5 Sphingomonadales 2.5.1.32,2.5.1.99 ko:K02291 ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110 M00097 R02065,R04218,R07270,R10177 RC00362,RC01101,RC02869 ko00000,ko00001,ko00002,ko01000,ko01006 Bacteria 1N5V2@1224,2K4II@204457,2UBZJ@28211,COG1562@1,COG1562@2 NA|NA|NA I ergosterol biosynthetic process HIMHAPGP_02093 1030157.AFMP01000008_gene3208 2.1e-66 258.8 Sphingomonadales dapF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 Bacteria 1MWDH@1224,2K1PV@204457,2TUF2@28211,COG0253@1,COG0253@2 NA|NA|NA E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan HIMHAPGP_02094 1248917.ANFX01000037_gene2178 5.4e-84 318.2 Sphingomonadales mtaB GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035598,GO:0035600,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050497,GO:0071704,GO:0090304,GO:1901360 2.8.4.5 ko:K18707 R10649 RC00003,RC03221 ko00000,ko01000,ko03016 Bacteria 1MUCS@1224,2K0WZ@204457,2TRYD@28211,COG0621@1,COG0621@2 NA|NA|NA J 2-methylthioadenine HIMHAPGP_02095 1234595.C725_1558 7.5e-108 397.1 unclassified Alphaproteobacteria ftsY ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 Bacteria 1MUDU@1224,2TS0M@28211,4BPVU@82117,COG0552@1,COG0552@2 NA|NA|NA U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components HIMHAPGP_02096 1187851.A33M_2145 6e-42 177.6 Rhodovulum ispZ GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K06190 ko00000 Bacteria 1NWIZ@1224,2U74X@28211,3FDAR@34008,COG2917@1,COG2917@2 NA|NA|NA D probably involved in intracellular septation HIMHAPGP_02097 1030157.AFMP01000004_gene2072 9.9e-72 276.2 Sphingomonadales sufB GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006790,GO:0008150,GO:0008152,GO:0009536,GO:0009842,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0071840 ko:K07033,ko:K09014 ko00000 iAPECO1_1312.APECO1_760,iECH74115_1262.ECH74115_2397,iECSF_1327.ECSF_1543,iECSP_1301.ECSP_2250,iUTI89_1310.UTI89_C1875,ic_1306.c2078 Bacteria 1MVKY@1224,2K196@204457,2TRU6@28211,COG0719@1,COG0719@2 NA|NA|NA O ABC-type transport system involved in Fe-S cluster assembly, permease component HIMHAPGP_02098 745310.G432_08800 1.3e-99 369.4 Sphingomonadales sufC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0071840 ko:K09013 ko00000,ko02000 iECH74115_1262.ECH74115_2396,iECIAI1_1343.ECIAI1_1734,iECIAI39_1322.ECIAI39_1376,iECSP_1301.ECSP_2249,iECs_1301.ECs2389,iEcSMS35_1347.EcSMS35_1514,iG2583_1286.G2583_2077,iSFV_1184.SFV_1705,iSFxv_1172.SFxv_1919,iSSON_1240.SSON_1474,iS_1188.S1844,iZ_1308.Z2710 Bacteria 1MUGK@1224,2K0E3@204457,2TS8T@28211,COG0396@1,COG0396@2 NA|NA|NA O ABC-type transport system involved in Fe-S cluster assembly, ATPase component HIMHAPGP_02099 1192759.AKIB01000072_gene608 3.5e-60 238.4 Sphingomonadales sufD GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0040007,GO:0043207,GO:0044085,GO:0044237,GO:0044403,GO:0044419,GO:0050896,GO:0051186,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071840,GO:0075136 ko:K09015 ko00000 iB21_1397.B21_01640,iECBD_1354.ECBD_1964,iECB_1328.ECB_01650,iECD_1391.ECD_01650,iUMNK88_1353.UMNK88_2144 Bacteria 1MVK0@1224,2K20T@204457,2TTK9@28211,COG0719@1,COG0719@2 NA|NA|NA O ABC-type transport system involved in Fe-S cluster assembly, permease component HIMHAPGP_02100 745310.G432_08790 8.8e-149 533.5 Sphingomonadales sufS GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 2.8.1.7,4.4.1.16 ko:K04487,ko:K11717 ko00450,ko00730,ko01100,ko04122,map00450,map00730,map01100,map04122 R03599,R07460,R11528,R11529 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 Bacteria 1MUPD@1224,2JZVI@204457,2TRNY@28211,COG0520@1,COG0520@2 NA|NA|NA E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine HIMHAPGP_02101 1207055.C100_02450 2.4e-47 195.3 Sphingomonadales paaD ko:K02612 ko00360,ko01120,map00360,map01120 R09838 RC02690 ko00000,ko00001 Bacteria 1MZ9Y@1224,2K4IC@204457,2U72U@28211,COG2151@1,COG2151@2 NA|NA|NA S FeS assembly SUF system protein HIMHAPGP_02102 1123267.JONN01000001_gene2063 6.4e-39 166.8 Sphingomonadales iscA GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009058,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0018130,GO:0019438,GO:0019538,GO:0022607,GO:0031163,GO:0031974,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051540,GO:0051604,GO:0070013,GO:0071704,GO:0071840,GO:0097428,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 ko:K13628,ko:K15724,ko:K22063 ko00000,ko03016,ko03029 Bacteria 1RH6T@1224,2K4FF@204457,2UBWJ@28211,COG0316@1,COG0316@2 NA|NA|NA S Belongs to the HesB IscA family HIMHAPGP_02103 1030157.AFMP01000031_gene2939 1.6e-42 179.5 Sphingomonadales hda GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008156,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030174,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:2000104,GO:2000112,GO:2000113 ko:K02313,ko:K10763 ko02020,ko04112,map02020,map04112 ko00000,ko00001,ko03032,ko03036 Bacteria 1N4PG@1224,2K4AT@204457,2U96K@28211,COG0593@1,COG0593@2 NA|NA|NA L ATPase involved in DNA replication HIMHAPGP_02104 1248760.ANFZ01000009_gene1300 9.3e-72 277.7 Sphingomonadales VV2512 ko:K09938 ko00000 Bacteria 1R81G@1224,2K0TT@204457,2U1EP@28211,COG3249@1,COG3249@2 NA|NA|NA S protein conserved in bacteria HIMHAPGP_02105 935557.ATYB01000009_gene994 7.1e-93 347.1 Rhizobiaceae Bacteria 1PWCG@1224,2UNPE@28211,4BBNQ@82115,COG1028@1,COG1028@2 NA|NA|NA IQ Enoyl-(Acyl carrier protein) reductase HIMHAPGP_02106 1040986.ATYO01000003_gene5939 3.8e-168 597.8 Phyllobacteriaceae dgoD Bacteria 1MURK@1224,2TRS9@28211,43JIX@69277,COG4948@1,COG4948@2 NA|NA|NA M Mandelate racemase / muconate lactonizing enzyme, C-terminal domain HIMHAPGP_02107 935557.ATYB01000009_gene988 1.8e-69 269.2 Rhizobiaceae ko:K05799 ko00000,ko03000 Bacteria 1RBCJ@1224,2U88W@28211,4BM8R@82115,COG2186@1,COG2186@2 NA|NA|NA K FCD HIMHAPGP_02108 1267535.KB906767_gene4128 9.7e-123 446.8 Bacteria Bacteria 2E5U1@1,330IC@2 NA|NA|NA S Sugar-binding cellulase-like HIMHAPGP_02109 536019.Mesop_2857 6e-83 314.3 Phyllobacteriaceae ko:K14274 ko00040,map00040 R02427 RC00713 ko00000,ko00001,ko01000 Bacteria 1MWTR@1224,2U3WG@28211,43KHM@69277,COG3386@1,COG3386@2 NA|NA|NA G SMP-30/Gluconolaconase/LRE-like region HIMHAPGP_02110 1068980.ARVW01000001_gene1773 1.6e-99 369.8 Pseudonocardiales Bacteria 2IDQT@201174,4DXKA@85010,COG2234@1,COG2234@2 NA|NA|NA S aminopeptidase activity HIMHAPGP_02111 1123240.ATVO01000003_gene595 2.7e-46 191.8 Alphaproteobacteria hscB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051604,GO:0071704,GO:0097428,GO:1901564,GO:1902494,GO:1990230,GO:1990234 ko:K04082,ko:K05801 ko00000,ko03029,ko03110 Bacteria 1N270@1224,2TTX1@28211,COG1076@1,COG1076@2 NA|NA|NA O COG1076 DnaJ-domain-containing proteins 1 HIMHAPGP_02112 1248916.ANFY01000008_gene2126 1.6e-75 289.7 Sphingomonadales ko:K15268 ko00000,ko02000 2.A.7.3.2 Bacteria 1MVKG@1224,2KD33@204457,2U5Y9@28211,COG0697@1,COG0697@2 NA|NA|NA EG EamA-like transporter family HIMHAPGP_02113 13689.BV96_03800 9.5e-74 283.5 Sphingomonadales amiD GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008745,GO:0009056,GO:0009057,GO:0009253,GO:0009254,GO:0009392,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0019867,GO:0030203,GO:0043167,GO:0043169,GO:0043170,GO:0046872,GO:0046914,GO:0061783,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 2.5.1.3,3.5.1.28 ko:K00788,ko:K01447 ko00730,ko01100,map00730,map01100 M00127 R03223,R04112,R10712 RC00064,RC00141,RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 Bacteria 1RDHU@1224,2K0W6@204457,2TSW3@28211,COG3023@1,COG3023@2 NA|NA|NA V N-acetylmuramoyl-L-alanine amidase HIMHAPGP_02114 392499.Swit_0080 1.6e-73 283.1 Sphingomonadales Bacteria 1MXQX@1224,2K2YY@204457,2U1V8@28211,COG1228@1,COG1228@2 NA|NA|NA Q amidohydrolase HIMHAPGP_02115 990285.RGCCGE502_15860 1.3e-175 623.2 Rhizobiaceae Bacteria 1MU0K@1224,2TSFS@28211,4B9FX@82115,COG0471@1,COG0471@2 NA|NA|NA P Sodium:sulfate symporter transmembrane region HIMHAPGP_02116 436229.JOEH01000017_gene6987 2e-142 512.7 Streptacidiphilus ydaH ko:K12942 ko00000 Bacteria 2GN45@201174,2NHJH@228398,COG2978@1,COG2978@2 NA|NA|NA H AbgT putative transporter family HIMHAPGP_02117 1122185.N792_04025 1.2e-41 176.0 Xanthomonadales Bacteria 1MXP2@1224,1RR76@1236,1X5E7@135614,COG1275@1,COG1275@2 NA|NA|NA P Voltage-dependent anion channel HIMHAPGP_02118 1248916.ANFY01000005_gene2763 5.3e-184 650.6 Sphingomonadales edd GO:0003674,GO:0003824,GO:0004456,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019520,GO:0019521,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046177,GO:0046395,GO:0071704,GO:0072329,GO:1901575 4.2.1.12 ko:K01690 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00008 R02036 RC00543 ko00000,ko00001,ko00002,ko01000 iEcolC_1368.EcolC_1781,iJN746.PP_1010,iPC815.YPO2533,iYL1228.KPN_02366 Bacteria 1MU3T@1224,2K1X3@204457,2TQNS@28211,COG0129@1,COG0129@2 NA|NA|NA EG Belongs to the IlvD Edd family HIMHAPGP_02119 1336208.JADY01000004_gene3669 4.1e-93 348.2 Rhodospirillales glk 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 1MVFI@1224,2JS5Q@204441,2U0CA@28211,COG0837@1,COG0837@2 NA|NA|NA G Belongs to the bacterial glucokinase family HIMHAPGP_02120 441620.Mpop_1962 4e-70 271.2 Methylobacteriaceae eda GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 4.1.2.14,4.1.3.42 ko:K01625 ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200 M00008,M00061,M00308,M00631 R00470,R05605 RC00307,RC00308,RC00435 ko00000,ko00001,ko00002,ko01000 Bacteria 1JSKN@119045,1MUVJ@1224,2TUMH@28211,COG0800@1,COG0800@2 NA|NA|NA G PFAM KDPG and KHG aldolase HIMHAPGP_02121 1336235.JAEG01000006_gene767 5.9e-89 334.0 Rhizobiaceae ung GO:0003674,GO:0003824,GO:0004844,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0097510,GO:0140097,GO:1901360 3.2.2.27 ko:K03648 ko03410,ko05340,map03410,map05340 ko00000,ko00001,ko01000,ko03400 Bacteria 1MV80@1224,2U1VI@28211,4B9C5@82115,COG0692@1,COG0692@2 NA|NA|NA L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine HIMHAPGP_02122 1479239.JQMU01000001_gene1528 4.4e-104 384.4 Alphaproteobacteria mscS ko:K03442 ko00000,ko02000 1.A.23.2 Bacteria 1N596@1224,2TR7U@28211,COG0668@1,COG0668@2 NA|NA|NA M COG0668 Small-conductance mechanosensitive channel HIMHAPGP_02123 1122612.AUBA01000012_gene626 1.6e-31 142.1 Alphaproteobacteria Bacteria 1Q2SM@1224,2UJ17@28211,COG3245@1,COG3245@2 NA|NA|NA C Cytochrome C oxidase, cbb3-type, subunit III HIMHAPGP_02124 1122612.AUBA01000012_gene627 8.2e-159 567.0 Sphingomonadales 1.1.3.8 ko:K00103 ko00053,ko01100,map00053,map01100 M00129 R00647,R03184,R10053 RC00195,RC00346,RC00869 ko00000,ko00001,ko00002,ko01000 Bacteria 1NB6A@1224,2K528@204457,2U3ZG@28211,COG0277@1,COG0277@2 NA|NA|NA C D-arabinono-1,4-lactone oxidase HIMHAPGP_02125 1122612.AUBA01000012_gene628 7.2e-114 417.5 Alphaproteobacteria Bacteria 1MXV3@1224,2TTPK@28211,COG3616@1,COG3616@2 NA|NA|NA E amino acid aldolase or racemase HIMHAPGP_02126 1389489.O159_17290 8.2e-08 66.2 Actinobacteria Bacteria 2GNZY@201174,COG2931@1,COG2931@2 NA|NA|NA Q Right handed beta helix region HIMHAPGP_02127 1172190.M947_03090 1.3e-48 200.7 Epsilonproteobacteria ko:K02014 ko00000,ko02000 1.B.14 Bacteria 1MUC1@1224,2YNY6@29547,42NGM@68525,COG1629@1,COG4771@2 NA|NA|NA P TonB dependent receptor HIMHAPGP_02128 314225.ELI_13675 4.7e-110 404.4 Sphingomonadales cysD 1.8.4.10,1.8.4.8,2.7.7.4 ko:K00390,ko:K00957 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R02021,R04929 RC00007,RC02809,RC02862,RC02889 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUCZ@1224,2K1HF@204457,2TT2D@28211,COG0175@1,COG0175@2 NA|NA|NA EH sulfate adenylyltransferase HIMHAPGP_02129 450851.PHZ_c2247 5.1e-31 141.4 Caulobacterales Bacteria 1N208@1224,2KHXC@204458,2UDE9@28211,COG1309@1,COG1309@2 NA|NA|NA K transcriptional regulator HIMHAPGP_02131 745310.G432_10615 9.7e-75 287.0 Sphingomonadales 3.1.3.15,3.1.3.25,3.1.3.93 ko:K01092,ko:K05602,ko:K18649 ko00053,ko00340,ko00521,ko00562,ko01100,ko01110,ko01230,ko04070,map00053,map00340,map00521,map00562,map01100,map01110,map01230,map04070 M00026,M00114,M00131 R01185,R01186,R01187,R03013,R07674 RC00017,RC00078 ko00000,ko00001,ko00002,ko01000 Bacteria 1PPJ0@1224,2K0WC@204457,2TQTX@28211,COG0483@1,COG0483@2 NA|NA|NA G COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family HIMHAPGP_02132 1499686.BN1079_00385 1.5e-119 437.2 Gammaproteobacteria plpD ko:K07001 ko00000 Bacteria 1MUM9@1224,1RRSK@1236,COG1752@1,COG1752@2,COG4775@1,COG4775@2 NA|NA|NA K esterase of the alpha-beta hydrolase superfamily HIMHAPGP_02133 1000565.METUNv1_01281 4.2e-61 241.5 Rhodocyclales modA ko:K02020 ko02010,map02010 M00189 ko00000,ko00001,ko00002,ko02000 3.A.1.8 Bacteria 1MVNA@1224,2KU6S@206389,2VJEC@28216,COG0725@1,COG0725@2 NA|NA|NA P Molybdenum ABC transporter periplasmic molybdate-binding protein HIMHAPGP_02134 376733.IT41_01265 1.4e-09 68.9 Paracoccus Bacteria 1NHD4@1224,2DR05@1,2PXU9@265,2UJCD@28211,339MI@2 NA|NA|NA S Peptidase inhibitor I78 family HIMHAPGP_02136 1088721.NSU_4334 5.2e-297 1026.5 Sphingomonadales acsA 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 1MUF5@1224,2K0M5@204457,2TRKS@28211,COG0365@1,COG0365@2 NA|NA|NA I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA HIMHAPGP_02137 1123240.ATVO01000005_gene1919 4.3e-77 294.7 Sphingomonadales Bacteria 1MUPX@1224,2K269@204457,2TT6C@28211,COG1028@1,COG1028@2 NA|NA|NA IQ KR domain HIMHAPGP_02138 1030157.AFMP01000002_gene2135 5.9e-283 980.3 Sphingomonadales ko:K02014 ko00000,ko02000 1.B.14 Bacteria 1MWKN@1224,2K0SD@204457,2TTI2@28211,COG1629@1,COG4771@2 NA|NA|NA P COG1629 Outer membrane receptor proteins, mostly Fe transport HIMHAPGP_02139 1292034.OR37_00853 1.2e-62 246.5 Caulobacterales Bacteria 1MUZE@1224,2KF5S@204458,2TT6M@28211,COG1814@1,COG1814@2 NA|NA|NA S VIT family HIMHAPGP_02140 1248916.ANFY01000004_gene1731 4.1e-250 871.3 Sphingomonadales ko:K07263 ko00000,ko01000,ko01002 Bacteria 1MVST@1224,2K05M@204457,2TRFB@28211,COG0612@1,COG0612@2 NA|NA|NA S Peptidase, M16 HIMHAPGP_02141 745310.G432_15180 1.2e-217 763.1 Sphingomonadales pepN GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0009056,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0033218,GO:0034641,GO:0042277,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 iECIAI1_1343.ECIAI1_0973,iECO103_1326.ECO103_0977,iECP_1309.ECP_0944,iECSE_1348.ECSE_0993,iECW_1372.ECW_m1042,iEKO11_1354.EKO11_2898,iWFL_1372.ECW_m1042 Bacteria 1MUCI@1224,2K072@204457,2TRUM@28211,COG0308@1,COG0308@2 NA|NA|NA E aminopeptidase N HIMHAPGP_02143 745310.G432_10415 1.8e-49 202.2 Sphingomonadales MA20_02250 ko:K09985 ko00000 Bacteria 1N1FE@1224,2K35H@204457,2U7H9@28211,COG3814@1,COG3814@2 NA|NA|NA S protein conserved in bacteria HIMHAPGP_02144 1248916.ANFY01000005_gene2741 5.8e-118 430.6 Sphingomonadales Bacteria 1MXNQ@1224,2K07N@204457,2TS6G@28211,COG1028@1,COG1028@2 NA|NA|NA IQ Belongs to the short-chain dehydrogenases reductases (SDR) family HIMHAPGP_02146 1248916.ANFY01000005_gene2740 2.8e-35 154.5 Sphingomonadales Bacteria 1MY2Z@1224,2K0QB@204457,2TRFZ@28211,COG0745@1,COG0745@2 NA|NA|NA T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain HIMHAPGP_02147 1248916.ANFY01000003_gene600 1.5e-278 965.7 Sphingomonadales dinG 3.6.4.12 ko:K03722 ko00000,ko01000,ko03400 Bacteria 1MVCU@1224,2K15X@204457,2TUKS@28211,COG1199@1,COG1199@2 NA|NA|NA KL Helicase HIMHAPGP_02148 629773.AORY01000002_gene1698 5.9e-49 200.7 Sphingomonadales sixA ko:K08296 ko00000,ko01000 Bacteria 1N0FX@1224,2K4JB@204457,2UBYD@28211,COG2062@1,COG2062@2 NA|NA|NA T phosphohistidine phosphatase HIMHAPGP_02149 1123240.ATVO01000004_gene1169 5.3e-91 340.9 Sphingomonadales mlaE ko:K02066 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 1MVPN@1224,2K2EI@204457,2TSGS@28211,COG0767@1,COG0767@2 NA|NA|NA Q Permease MlaE HIMHAPGP_02150 392499.Swit_0015 1.4e-91 342.8 Sphingomonadales mkl ko:K02065 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 1MUSD@1224,2K25X@204457,2TR2I@28211,COG1127@1,COG1127@2 NA|NA|NA Q PFAM ABC transporter related HIMHAPGP_02152 1007104.SUS17_2351 1.2e-38 166.0 Sphingomonadales atm1 GO:0003674,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006996,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009507,GO:0009526,GO:0009536,GO:0009555,GO:0009657,GO:0009658,GO:0009889,GO:0009941,GO:0009987,GO:0010035,GO:0010038,GO:0010288,GO:0010380,GO:0016020,GO:0016043,GO:0018130,GO:0019222,GO:0019538,GO:0019637,GO:0019720,GO:0019725,GO:0019866,GO:0022622,GO:0030003,GO:0031090,GO:0031323,GO:0031326,GO:0031966,GO:0031967,GO:0031975,GO:0032501,GO:0032502,GO:0042221,GO:0042592,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0046686,GO:0046916,GO:0048229,GO:0048364,GO:0048731,GO:0048856,GO:0048878,GO:0050789,GO:0050790,GO:0050794,GO:0050801,GO:0050896,GO:0051171,GO:0051186,GO:0051188,GO:0051189,GO:0051193,GO:0051276,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0065009,GO:0071704,GO:0071840,GO:0090056,GO:0090407,GO:0098771,GO:0099402,GO:1901360,GO:1901362,GO:1901401,GO:1901463,GO:1901564,GO:1901566,GO:1901576 ko:K06147,ko:K12531 ko02020,map02020 M00326 ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.106,3.A.1.109,3.A.1.21 Bacteria 1NSKS@1224,2K16I@204457,2UQAG@28211,COG5265@1,COG5265@2 NA|NA|NA V ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase HIMHAPGP_02154 1114964.L485_04155 2.3e-222 778.5 Sphingomonadales uup GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010528,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031323,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0070894,GO:0071944,GO:0080090,GO:0097159,GO:1901363 ko:K15738 ko00000,ko02000 3.A.1.120.6 Bacteria 1MU37@1224,2K0QQ@204457,2TR3X@28211,COG0488@1,COG0488@2 NA|NA|NA S of ABC transporters with duplicated ATPase HIMHAPGP_02155 1123267.JONN01000002_gene227 1.2e-167 596.3 Sphingomonadales phaZ 3.1.1.75 ko:K05973 ko00650,map00650 R05118 ko00000,ko00001,ko01000 Bacteria 1MVUH@1224,2K1W9@204457,2TQXW@28211,COG4553@1,COG4553@2 NA|NA|NA I de-polymerase HIMHAPGP_02156 400682.PAC_15698686 1.7e-50 206.8 Eukaryota Eukaryota 2EMGT@1,2SR5E@2759 NA|NA|NA HIMHAPGP_02157 685778.AORL01000006_gene3435 7.5e-33 146.7 Sphingomonadales sdhD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K00242 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173 R02164 RC00045 ko00000,ko00001,ko00002 Bacteria 1MZND@1224,2K550@204457,2UC3G@28211,COG2142@1,COG2142@2 NA|NA|NA C succinate dehydrogenase HIMHAPGP_02158 1234595.C725_0529 7.7e-30 136.7 Alphaproteobacteria sdhC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K00241 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 Bacteria 1N02N@1224,2UC47@28211,COG2009@1,COG2009@2 NA|NA|NA C succinate dehydrogenase HIMHAPGP_02159 1248916.ANFY01000017_gene1348 1.8e-40 172.2 Sphingomonadales Bacteria 1MZRC@1224,2KDC7@204457,2VGRQ@28211,COG5470@1,COG5470@2 NA|NA|NA S Domain of unknown function (DUF1330) HIMHAPGP_02160 1470591.BW41_00155 4.1e-32 144.8 Sphingomonadales pnuC ko:K03811 ko00000,ko02000 4.B.1.1 Bacteria 1MXN4@1224,2K4GB@204457,2UAA3@28211,COG3201@1,COG3201@2 NA|NA|NA H nicotinamide mononucleotide transporter HIMHAPGP_02161 1090318.ATTI01000001_gene1552 1.3e-29 136.3 Sphingomonadales nadR Bacteria 1MUSI@1224,2K65Q@204457,2UAKD@28211,COG3172@1,COG3172@2 NA|NA|NA H AAA domain HIMHAPGP_02162 317655.Sala_0554 3.7e-70 271.9 Sphingomonadales prmA ko:K02687 ko00000,ko01000,ko03009 Bacteria 1MUPC@1224,2K0Q7@204457,2TTP3@28211,COG2264@1,COG2264@2 NA|NA|NA J ribosomal protein L11 HIMHAPGP_02163 1030157.AFMP01000031_gene2861 1.2e-214 753.1 Sphingomonadales ligA GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 Bacteria 1MV3R@1224,2K00E@204457,2TRHK@28211,COG0272@1,COG0272@2 NA|NA|NA L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA HIMHAPGP_02164 1122970.AUHC01000001_gene562 8.6e-23 114.0 Sphingomonadales comA ko:K02238 M00429 ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 Bacteria 1MUKF@1224,2K0XJ@204457,2TRD5@28211,COG0658@1,COG0658@2 NA|NA|NA S membrane metal-binding protein # 1919 queries scanned # Total time (seconds): 30.4097750187 # Rate: 63.10 q/s