# emapper version: emapper-2.0.1 emapper DB: 2.0 # command: ./emapper.py -m diamond --seed_ortholog_evalue 0.00001 --data_dir /home/bayegy/Databases/emapper/data_dir2.0.1/ --cpu 45 --temp_dir /media/bayegy/disk0/binning_test/Bin_all/emapper//bin.C2.4/_tmp -i /media/bayegy/disk0/binning_test/Bin_all/Bin_prokka//bin.C2.4/bin.C2.4.faa -o /media/bayegy/disk0/binning_test/Bin_all/emapper//bin.C2.4/bin.C2.4 --usemem --override # time: Wed Nov 3 19:18:25 2021 #query_name seed_eggNOG_ortholog seed_ortholog_evalue seed_ortholog_score best_tax_level Preferred_name GOs EC KEGG_ko KEGG_Pathway KEGG_Module KEGG_Reaction KEGG_rclass BRITE KEGG_TC CAZy BiGG_Reaction taxonomic scope eggNOG OGs best eggNOG OG COG Functional cat. eggNOG free text desc. PFHLONEA_00001 880071.Fleli_0041 2.6e-57 229.2 Cytophagia glmS GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 iAF987.Gmet_1487 Bacteria 47KVG@768503,4NE8Q@976,COG0449@1,COG0449@2 NA|NA|NA M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source PFHLONEA_00004 1232410.KI421420_gene3183 4.1e-45 188.7 Desulfuromonadales 5.2.1.8 ko:K03769,ko:K07533 ko00000,ko01000,ko03110 Bacteria 1RKBZ@1224,2WPWG@28221,42SAP@68525,43SKZ@69541,COG0760@1,COG0760@2 NA|NA|NA O SurA N-terminal domain PFHLONEA_00005 1158318.ATXC01000001_gene16 2.6e-09 69.3 Bacteria surA 5.2.1.8 ko:K03769,ko:K03771 ko00000,ko01000,ko03110 Bacteria COG0760@1,COG0760@2 NA|NA|NA O peptidyl-prolyl cis-trans isomerase activity PFHLONEA_00006 404380.Gbem_0214 1.8e-271 942.6 Desulfuromonadales mfd GO:0000715,GO:0000716,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006289,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031326,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051276,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1903506,GO:2000112,GO:2001141 ko:K03723 ko03420,map03420 ko00000,ko00001,ko01000,ko03400 Bacteria 1MUXG@1224,2WIVR@28221,42N8X@68525,43TS2@69541,COG1197@1,COG1197@2 NA|NA|NA L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site PFHLONEA_00007 1125863.JAFN01000001_gene1819 1.1e-294 1018.8 Deltaproteobacteria prpE 6.2.1.1,6.2.1.17 ko:K01895,ko:K01908 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 1MUF5@1224,2WJY2@28221,42MHP@68525,COG0365@1,COG0365@2 NA|NA|NA I PFAM AMP-dependent synthetase and ligase PFHLONEA_00008 1131269.AQVV01000024_gene2355 3.7e-93 348.6 Bacteria csd Bacteria COG0520@1,COG0520@2 NA|NA|NA E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine PFHLONEA_00010 237368.SCABRO_01271 1.3e-247 862.4 Planctomycetes htpG GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010035,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0042623,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0070887,GO:0071450,GO:0071451,GO:0071944,GO:1901700,GO:1901701 ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 Bacteria 2IYC7@203682,COG0326@1,COG0326@2 NA|NA|NA O Molecular chaperone. Has ATPase activity PFHLONEA_00011 671143.DAMO_1148 1.3e-111 409.8 unclassified Bacteria acuC ko:K04768 ko00000 Bacteria 2NP8V@2323,COG0123@1,COG0123@2 NA|NA|NA BQ Histone deacetylase domain PFHLONEA_00013 1173026.Glo7428_4012 7.4e-99 367.9 Cyanobacteria ko:K01138 ko00000,ko01000 Bacteria 1G5IZ@1117,COG3119@1,COG3119@2 NA|NA|NA P Arylsulfatase a PFHLONEA_00014 1267535.KB906767_gene5480 6.1e-32 143.7 Acidobacteriia polA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7,3.1.26.4 ko:K02335,ko:K03469 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 Bacteria 2JHXN@204432,3Y3X3@57723,COG0258@1,COG0258@2,COG0749@1,COG0749@2 NA|NA|NA L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity PFHLONEA_00015 1121918.ARWE01000001_gene1125 1.6e-29 136.0 delta/epsilon subdivisions 2.7.13.3 ko:K03406,ko:K07710 ko02020,ko02030,map02020,map02030 M00500 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 Bacteria 1NU7E@1224,42NE2@68525,COG5000@1,COG5000@2 NA|NA|NA T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PFHLONEA_00016 589865.DaAHT2_0407 1.1e-139 503.4 Deltaproteobacteria Bacteria 1MU0N@1224,2WKJX@28221,42M03@68525,COG2204@1,COG2204@2 NA|NA|NA T response regulator PFHLONEA_00017 589865.DaAHT2_0408 4.6e-23 115.2 Deltaproteobacteria Bacteria 1P20B@1224,2WWZW@28221,431TD@68525,COG0745@1,COG0745@2 NA|NA|NA T cheY-homologous receiver domain PFHLONEA_00018 404589.Anae109_2067 5.4e-99 368.6 Deltaproteobacteria Bacteria 1PFUI@1224,2WRN3@28221,42W2K@68525,COG0457@1,COG0457@2 NA|NA|NA S TPR repeat-containing protein PFHLONEA_00019 1499967.BAYZ01000017_gene6259 6.6e-53 214.9 unclassified Bacteria Bacteria 2NPW4@2323,COG1215@1,COG1215@2 NA|NA|NA M Glycosyl transferase family 2 PFHLONEA_00020 404380.Gbem_1106 1.4e-09 70.9 Desulfuromonadales Bacteria 1NFQW@1224,2WKWA@28221,42MT2@68525,43TXB@69541,COG0457@1,COG0457@2 NA|NA|NA S PFAM Tetratricopeptide TPR_1 repeat-containing protein PFHLONEA_00023 1266925.JHVX01000004_gene1249 5.4e-187 661.0 Nitrosomonadales nuoG 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 1P8MN@1224,2VJYV@28216,373XN@32003,COG1034@1,COG1034@2 NA|NA|NA C Molybdopterin oxidoreductase Fe4S4 domain PFHLONEA_00024 443143.GM18_0879 6.3e-70 270.4 Desulfuromonadales bcsA GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0016747 2.3.1.246 ko:K16424 ko01055,ko01130,map01055,map01130 R06625 RC00004,RC02933 ko00000,ko00001,ko01000 Bacteria 1MUDX@1224,2WQ17@28221,42UCQ@68525,43V66@69541,COG3424@1,COG3424@2 NA|NA|NA Q Chalcone and stilbene synthases, C-terminal domain PFHLONEA_00025 768706.Desor_1563 1.3e-44 186.4 Clostridia Bacteria 1TT7G@1239,24E44@186801,COG0500@1,COG2226@2 NA|NA|NA Q NOG31153 non supervised orthologous group PFHLONEA_00026 1123371.ATXH01000001_gene1211 1e-38 166.4 Thermodesulfobacteria Bacteria 2E978@1,2GIHH@200940,333FR@2 NA|NA|NA PFHLONEA_00028 330214.NIDE0245 5.2e-100 370.9 Nitrospirae pepA GO:0001073,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006351,GO:0006355,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009056,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016787,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019538,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042150,GO:0043170,GO:0043171,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043244,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0097718,GO:0140096,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1903506,GO:2000112,GO:2001141 3.4.11.1,3.4.11.5 ko:K01255,ko:K01259 ko00330,ko00480,ko01100,map00330,map00480,map01100 R00135,R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 Bacteria 3J0X7@40117,COG0260@1,COG0260@2 NA|NA|NA E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides PFHLONEA_00029 335543.Sfum_3313 2.9e-66 258.8 Syntrophobacterales Bacteria 1MWVU@1224,2MQEZ@213462,2WKB8@28221,42PMQ@68525,COG0583@1,COG0583@2 NA|NA|NA K LysR substrate binding domain PFHLONEA_00030 469610.HMPREF0189_00196 9.6e-19 100.5 Proteobacteria Bacteria 1N75K@1224,COG0515@1,COG0515@2 NA|NA|NA KLT serine threonine protein kinase PFHLONEA_00031 1304275.C41B8_15570 2.7e-20 105.5 Gammaproteobacteria Bacteria 1RJNV@1224,1SGB2@1236,COG2020@1,COG2020@2 NA|NA|NA O Phospholipid methyltransferase PFHLONEA_00032 404589.Anae109_2493 6.4e-258 896.7 Myxococcales uvrB GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009314,GO:0009380,GO:0009628,GO:0032991,GO:0042802,GO:0044424,GO:0044464,GO:0050896,GO:1902494,GO:1905347,GO:1905348,GO:1990391 ko:K03702,ko:K08999 ko03420,map03420 ko00000,ko00001,ko03400 Bacteria 1MUFK@1224,2WJ20@28221,2YU4B@29,42MFA@68525,COG0556@1,COG0556@2 NA|NA|NA L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage PFHLONEA_00033 909663.KI867150_gene658 1.5e-208 732.6 Syntrophobacterales ko:K06158 ko00000,ko03012 Bacteria 1MU37@1224,2MQRF@213462,2WIJY@28221,42M2A@68525,COG0488@1,COG0488@2 NA|NA|NA S ABC transporter PFHLONEA_00034 1266925.JHVX01000005_gene1919 3e-132 478.4 Nitrosomonadales MA20_09515 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 R01009 RC00005 ko00000,ko00001,ko01000,ko01003 GT2 Bacteria 1MV8J@1224,2W9NC@28216,3726J@32003,COG0463@1,COG0463@2,COG2246@1,COG2246@2 NA|NA|NA M GtrA-like protein PFHLONEA_00035 1123242.JH636435_gene2942 1e-69 270.8 Planctomycetes Bacteria 2E79V@1,2J35R@203682,331TF@2 NA|NA|NA S Pfam:DUF2029 PFHLONEA_00037 1217718.ALOU01000026_gene3564 5.9e-55 221.1 Burkholderiaceae lytR ko:K02477,ko:K07705 ko02020,map02020 M00492 ko00000,ko00001,ko00002,ko02022 Bacteria 1K0JH@119060,1MUE8@1224,2VKFT@28216,COG3279@1,COG3279@2 NA|NA|NA T response regulator PFHLONEA_00038 381666.H16_A3390 1.8e-46 193.0 Burkholderiaceae Bacteria 1KC26@119060,1MXVQ@1224,2VH9S@28216,COG2972@1,COG2972@2 NA|NA|NA T 2TM domain PFHLONEA_00040 237368.SCABRO_03569 3e-13 81.6 Planctomycetes Bacteria 29WUZ@1,2J4C2@203682,30IGG@2 NA|NA|NA PFHLONEA_00041 289376.THEYE_A0194 5.1e-50 204.5 Nitrospirae ko:K10914,ko:K21564 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 ko00000,ko00001,ko03000 Bacteria 3J18E@40117,COG0664@1,COG0664@2 NA|NA|NA K helix_turn_helix, cAMP Regulatory protein PFHLONEA_00042 379066.GAU_3340 5.1e-17 94.4 Bacteria Bacteria COG0454@1,COG0456@2 NA|NA|NA K acetyltransferase PFHLONEA_00043 760568.Desku_3145 4.2e-43 181.4 Clostridia coaE 2.7.1.24 ko:K00859 ko00770,ko01100,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 Bacteria 1V6FS@1239,24GFQ@186801,COG0237@1,COG0237@2 NA|NA|NA H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A PFHLONEA_00044 1396141.BATP01000028_gene2350 1.1e-15 90.5 Verrucomicrobiae Bacteria 2EKXK@1,2IUG6@203494,33EM4@2,46WCN@74201 NA|NA|NA PFHLONEA_00045 1089439.KB902251_gene1490 3.1e-143 515.0 Thiotrichales arnB 2.6.1.87 ko:K07806 ko00520,ko01503,ko02020,map00520,map01503,map02020 M00721,M00761 R07659 RC00006,RC01514 ko00000,ko00001,ko00002,ko01000,ko01005,ko01007 Bacteria 1MUPN@1224,1RMCS@1236,461RD@72273,COG0399@1,COG0399@2 NA|NA|NA E DegT/DnrJ/EryC1/StrS aminotransferase family PFHLONEA_00046 59196.RICGR_1237 5e-107 394.4 Legionellales arnC GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0044464,GO:0071944,GO:0099621 2.4.2.53 ko:K10012 ko00520,ko01503,map00520,map01503 M00721,M00761 R07661 RC00005,RC02954 ko00000,ko00001,ko00002,ko01000,ko01005,ko02000 4.D.2.1.8 GT2 iAPECO1_1312.APECO1_4307,iE2348C_1286.E2348C_2398,iECABU_c1320.ECABU_c25880,iECED1_1282.ECED1_2720,iECOK1_1307.ECOK1_2490,iECP_1309.ECP_2297,iECS88_1305.ECS88_2403,iLF82_1304.LF82_0138,iNRG857_1313.NRG857_11430,iUMN146_1321.UM146_05530,iUTI89_1310.UTI89_C2536,ic_1306.c2796 Bacteria 1JGKD@118969,1MWE5@1224,1RPCE@1236,COG0463@1,COG0463@2 NA|NA|NA M Glycosyltransferase like family 2 PFHLONEA_00047 452637.Oter_1412 1.8e-101 375.9 Opitutae arnA GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006040,GO:0006139,GO:0006725,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016741,GO:0016742,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0022607,GO:0033319,GO:0033320,GO:0034214,GO:0034641,GO:0034654,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046349,GO:0046483,GO:0046677,GO:0048037,GO:0048040,GO:0050662,GO:0050896,GO:0051259,GO:0051287,GO:0055086,GO:0055114,GO:0065003,GO:0070403,GO:0071704,GO:0071840,GO:0097159,GO:0099618,GO:0099619,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:2001313,GO:2001315 1.1.1.305,2.1.2.13,2.1.2.9 ko:K00604,ko:K10011 ko00520,ko00670,ko00970,ko01503,map00520,map00670,map00970,map01503 M00721,M00761 R03940,R07658,R07660 RC00026,RC00165,RC01575,RC01812 ko00000,ko00001,ko00002,ko01000,ko01005 iPC815.YPO2420,iSFV_1184.SFV_2325 Bacteria 3K7UM@414999,46SKS@74201,COG0223@1,COG0223@2 NA|NA|NA J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus PFHLONEA_00048 269799.Gmet_0883 2e-138 498.8 Deltaproteobacteria arnA GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006040,GO:0006139,GO:0006725,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016741,GO:0016742,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0022607,GO:0033319,GO:0033320,GO:0034214,GO:0034641,GO:0034654,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046349,GO:0046483,GO:0046677,GO:0048037,GO:0048040,GO:0050662,GO:0050896,GO:0051259,GO:0051287,GO:0055086,GO:0055114,GO:0065003,GO:0070403,GO:0071704,GO:0071840,GO:0097159,GO:0099618,GO:0099619,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:2001313,GO:2001315 1.1.1.305,2.1.2.13,5.1.3.2 ko:K01784,ko:K10011,ko:K12449,ko:K21332 ko00052,ko00520,ko00523,ko01100,ko01130,ko01503,map00052,map00520,map00523,map01100,map01130,map01503 M00361,M00362,M00632,M00721,M00761 R00291,R01384,R01386,R02984,R07658,R07660,R11472 RC00026,RC00289,RC00508,RC01575,RC01811,RC01812 ko00000,ko00001,ko00002,ko01000,ko01005 iPC815.YPO2420,iSFV_1184.SFV_2325 Bacteria 1MXKV@1224,2WIRV@28221,42QC6@68525,COG0451@1,COG0451@2 NA|NA|NA GM 3-beta hydroxysteroid dehydrogenase/isomerase family PFHLONEA_00049 59196.RICGR_1236 1.1e-98 366.7 Gammaproteobacteria arnD GO:0005575,GO:0008150,GO:0010035,GO:0010038,GO:0010039,GO:0010041,GO:0016020,GO:0042221,GO:0050896 ko:K13014 ko00520,ko01503,map00520,map01503 M00721,M00761 R07662 RC00323,RC01575 ko00000,ko00001,ko00002,ko01000,ko01005 iAF987.Gmet_0882,iB21_1397.B21_02141,iBWG_1329.BWG_2029,iEC042_1314.EC042_2499,iECBD_1354.ECBD_1403,iECB_1328.ECB_02182,iECDH10B_1368.ECDH10B_2416,iECDH1ME8569_1439.ECDH1ME8569_2192,iECD_1391.ECD_02182,iECO103_1326.ECO103_2722,iECO111_1330.ECO111_3006,iECO26_1355.ECO26_3246,iECUMN_1333.ECUMN_2597,iECW_1372.ECW_m2447,iEKO11_1354.EKO11_1508,iETEC_1333.ETEC_2390,iEcDH1_1363.EcDH1_1402,iEcHS_1320.EcHS_A2401,iEcolC_1368.EcolC_1393,iJO1366.b2256,iSFV_1184.SFV_2326,iSSON_1240.SSON_2317,iUMNK88_1353.UMNK88_2808,iWFL_1372.ECW_m2447,iY75_1357.Y75_RS11830 Bacteria 1N8Q4@1224,1RQ0R@1236,COG0726@1,COG0726@2 NA|NA|NA G Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides PFHLONEA_00050 243231.GSU3379 2.6e-109 402.1 Desulfuromonadales mtnA GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.23 ko:K08963 ko00270,ko01100,map00270,map01100 M00034 R04420 RC01151 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_0072 Bacteria 1MUPM@1224,2WJQB@28221,42MJ2@68525,43UJ9@69541,COG0182@1,COG0182@2 NA|NA|NA J Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) PFHLONEA_00052 273068.TTE1205 5.9e-25 120.2 Thermoanaerobacterales gluD 1.4.1.2,1.4.1.3 ko:K00260,ko:K00261 ko00220,ko00250,ko00430,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00430,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1TP45@1239,24960@186801,42FA1@68295,COG0334@1,COG0334@2 NA|NA|NA C Belongs to the Glu Leu Phe Val dehydrogenases family PFHLONEA_00054 398767.Glov_2055 8.8e-151 540.0 Deltaproteobacteria hyaL 1.12.99.6 ko:K06281 ko00633,ko01120,map00633,map01120 R08034 RC00250 ko00000,ko00001,ko01000 Bacteria 1MWFJ@1224,2WJQS@28221,42M4S@68525,COG0374@1,COG0374@2 NA|NA|NA C Belongs to the NiFe NiFeSe hydrogenase large subunit family PFHLONEA_00055 1232410.KI421412_gene145 6.1e-56 224.2 Desulfuromonadales cybH GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0020037,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044569,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0071944,GO:0097159,GO:1901363,GO:1902494 ko:K03620 ko02020,map02020 ko00000,ko00001 Bacteria 1MU87@1224,2X8MJ@28221,42NQ3@68525,43TMS@69541,COG1969@1,COG1969@2 NA|NA|NA C Domain of unknown function (DUF4405) PFHLONEA_00056 1123376.AUIU01000018_gene8 5.2e-42 177.6 Nitrospirae hybD ko:K03605 ko00000,ko01000,ko01002 Bacteria 3J16R@40117,COG0680@1,COG0680@2 NA|NA|NA C Hydrogenase maturation protease PFHLONEA_00057 289376.THEYE_A1390 1.3e-24 119.8 Bacteria hypA ko:K04651,ko:K19640 ko00000,ko02022,ko03110 Bacteria COG0375@1,COG0375@2 NA|NA|NA S nickel cation binding PFHLONEA_00058 714961.BFZC1_18515 1.9e-24 120.2 Lysinibacillus Bacteria 1UXI7@1239,3IZSH@400634,4HU0M@91061,COG4974@1,COG4974@2 NA|NA|NA L Belongs to the 'phage' integrase family PFHLONEA_00059 1215092.PA6_010_00230 7.9e-30 137.9 Pseudomonas aeruginosa group xerD GO:0000150,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009314,GO:0009628,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0071139,GO:0071704,GO:0090304,GO:0140097,GO:1901360 ko:K04763 ko00000,ko03036 Bacteria 1MVNF@1224,1RPI8@1236,1YCS9@136841,COG4974@1,COG4974@2 NA|NA|NA D Phage integrase, N-terminal SAM-like domain PFHLONEA_00062 1095769.CAHF01000022_gene361 4.1e-41 174.9 Betaproteobacteria Bacteria 1RBSP@1224,290UJ@1,2VZ0V@28216,2ZNGJ@2 NA|NA|NA PFHLONEA_00063 243231.GSU0810 1.9e-37 163.3 Deltaproteobacteria oprF GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 ko:K03286 ko00000,ko02000 1.B.6 Bacteria 1R8DG@1224,2WVVT@28221,42NGC@68525,COG2885@1,COG2885@2,COG3637@1,COG3637@2 NA|NA|NA M Belongs to the ompA family PFHLONEA_00064 1304872.JAGC01000005_gene1958 6.3e-30 136.3 Desulfovibrionales Bacteria 1MUEM@1224,2MA0Y@213115,2WMAY@28221,42PBT@68525,COG2207@1,COG2207@2 NA|NA|NA K AraC-type transcriptional regulator N-terminus PFHLONEA_00067 269799.Gmet_0156 1.2e-34 152.5 Deltaproteobacteria yeaO Bacteria 1MZ7H@1224,2WQ9M@28221,42U37@68525,COG3189@1,COG3189@2 NA|NA|NA S Protein of unknown function, DUF488 PFHLONEA_00068 742726.HMPREF9448_01175 5.4e-19 99.4 Porphyromonadaceae rubR Bacteria 22YNA@171551,2FUN6@200643,4NHF0@976,COG1773@1,COG1773@2 NA|NA|NA C Rubredoxin PFHLONEA_00069 269799.Gmet_3460 2.6e-136 491.9 Deltaproteobacteria ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1MW5R@1224,2WIJJ@28221,42NC3@68525,COG0842@1,COG0842@2 NA|NA|NA V PFAM ABC-2 type transporter PFHLONEA_00070 269799.Gmet_3461 7.1e-124 450.7 Deltaproteobacteria ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1MW5R@1224,2WJQA@28221,42P7V@68525,COG0842@1,COG0842@2 NA|NA|NA V PFAM ABC-2 type transporter PFHLONEA_00071 269799.Gmet_3462 1.1e-32 146.0 Deltaproteobacteria ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1MUX3@1224,2WK9W@28221,42MV1@68525,COG1131@1,COG1131@2 NA|NA|NA V PFAM ABC transporter PFHLONEA_00073 935948.KE386495_gene2002 5.3e-69 268.5 Thermoanaerobacterales Bacteria 1TQYX@1239,24AD5@186801,42FHR@68295,COG1251@1,COG1251@2 NA|NA|NA C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase PFHLONEA_00074 1123376.AUIU01000014_gene673 6.8e-81 307.0 Nitrospirae fdnG GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008430,GO:0009055,GO:0009061,GO:0009326,GO:0009987,GO:0015942,GO:0015944,GO:0015980,GO:0016491,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0030151,GO:0030288,GO:0030313,GO:0031975,GO:0032787,GO:0032991,GO:0033554,GO:0036397,GO:0042597,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046872,GO:0046914,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0052738,GO:0055114,GO:0071704,GO:1902494 1.17.1.9,1.17.5.3 ko:K00123,ko:K08348 ko00630,ko00680,ko01100,ko01120,ko01200,ko02020,map00630,map00680,map01100,map01120,map01200,map02020 R00519 RC02796 ko00000,ko00001,ko01000 5.A.3.2 iECW_1372.ECW_m4203,iECs_1301.ECs2078,iUMNK88_1353.UMNK88_1879,iWFL_1372.ECW_m4203,iYL1228.KPN_04190,iZ_1308.Z2236 Bacteria 3J0UR@40117,COG0243@1,COG0243@2,COG3383@1,COG3383@2 NA|NA|NA C Molydopterin dinucleotide binding domain PFHLONEA_00075 1121918.ARWE01000001_gene41 2.9e-81 308.5 Deltaproteobacteria fdoH GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009326,GO:0009897,GO:0009898,GO:0009986,GO:0009987,GO:0015942,GO:0015944,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0031224,GO:0031226,GO:0031233,GO:0031235,GO:0032787,GO:0032991,GO:0036397,GO:0043436,GO:0044237,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0052738,GO:0055114,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:1902494 ko:K00124,ko:K08349 ko00630,ko00680,ko01100,ko01120,ko01200,ko02020,map00630,map00680,map01100,map01120,map01200,map02020 R00519 RC02796 ko00000,ko00001 5.A.3.2 iAF1260.b3893,iAPECO1_1312.APECO1_2572,iB21_1397.B21_03727,iBWG_1329.BWG_3563,iEC042_1314.EC042_4267,iEC55989_1330.EC55989_4370,iECABU_c1320.ECABU_c43980,iECBD_1354.ECBD_4132,iECB_1328.ECB_03778,iECDH10B_1368.ECDH10B_4083,iECDH1ME8569_1439.ECDH1ME8569_3764,iECD_1391.ECD_03778,iECED1_1282.ECED1_4596,iECIAI1_1343.ECIAI1_4097,iECIAI39_1322.ECIAI39_3106,iECO103_1326.ECO103_4634,iECO26_1355.ECO26_4693,iECOK1_1307.ECOK1_4361,iECP_1309.ECP_1476,iECP_1309.ECP_4105,iECS88_1305.ECS88_4341,iECSE_1348.ECSE_4179,iECUMN_1333.ECUMN_4423,iECW_1372.ECW_m4202,iEKO11_1354.EKO11_4464,iEcDH1_1363.EcDH1_4091,iEcE24377_1341.EcE24377A_4422,iEcHS_1320.EcHS_A4121,iEcSMS35_1347.EcSMS35_4279,iEcolC_1368.EcolC_4125,iJO1366.b3893,iJR904.b3893,iLF82_1304.LF82_0634,iNRG857_1313.NRG857_19435,iSBO_1134.SBO_3907,iSFV_1184.SFV_3602,iSF_1195.SF3969,iSSON_1240.SSON_4062,iS_1188.S3779,iUMN146_1321.UM146_19695,iUMNK88_1353.UMNK88_4726,iUTI89_1310.UTI89_C4480,iWFL_1372.ECW_m4202,iY75_1357.Y75_RS17605,iYL1228.KPN_04189,ic_1306.c4843 Bacteria 1MU1B@1224,2WN0N@28221,42R3B@68525,COG0437@1,COG0437@2 NA|NA|NA C 4Fe-4S dicluster domain PFHLONEA_00076 56780.SYN_00605 1.9e-24 119.4 Deltaproteobacteria fdhC ko:K00127 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 R00519 RC02796 ko00000,ko00001 Bacteria 1MXFQ@1224,2WN3G@28221,42MVF@68525,COG2864@1,COG2864@2 NA|NA|NA C Prokaryotic cytochrome b561 PFHLONEA_00079 671143.DAMO_0863 2.8e-13 80.9 Bacteria Bacteria COG0861@1,COG0861@2 NA|NA|NA P Integral membrane protein TerC family PFHLONEA_00081 765911.Thivi_2827 1e-37 162.9 Chromatiales paaI GO:0003674,GO:0003824,GO:0016289,GO:0016787,GO:0016788,GO:0016790 ko:K02614 ko00360,map00360 R09840 RC00004,RC00014 ko00000,ko00001,ko01000 Bacteria 1RH35@1224,1S4YC@1236,1WYD8@135613,COG2050@1,COG2050@2 NA|NA|NA Q PFAM thioesterase superfamily PFHLONEA_00082 589865.DaAHT2_0098 9.3e-114 417.2 Desulfobacterales Bacteria 1QX38@1224,2MJE8@213118,2WK8G@28221,42NSX@68525,COG2271@1,COG2271@2 NA|NA|NA G PFAM Major Facilitator Superfamily PFHLONEA_00083 42256.RradSPS_2838 2.7e-25 121.3 Rubrobacteria Bacteria 2GMZV@201174,4CQ0T@84995,COG0262@1,COG0262@2 NA|NA|NA H PFAM bifunctional deaminase-reductase domain protein PFHLONEA_00084 485913.Krac_0452 7.9e-57 227.3 Bacteria Bacteria COG1335@1,COG1335@2 NA|NA|NA Q hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides PFHLONEA_00085 1449126.JQKL01000043_gene1900 7.7e-18 97.8 Clostridia Bacteria 1TPG1@1239,24BBE@186801,COG0247@1,COG0247@2 NA|NA|NA C Fe-S oxidoreductase PFHLONEA_00086 1265505.ATUG01000002_gene1134 7.1e-79 301.2 Desulfobacterales 1.8.98.1 ko:K08264 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 R04540 RC00011 ko00000,ko00001,ko01000 Bacteria 1MUMH@1224,2MN72@213118,2WN88@28221,42R1T@68525,COG0247@1,COG0247@2 NA|NA|NA C Cysteine-rich domain PFHLONEA_00087 1268622.AVS7_02516 1.4e-42 179.1 Betaproteobacteria Bacteria 1RHZY@1224,2B047@1,2W3AW@28216,31SEM@2 NA|NA|NA PFHLONEA_00088 290317.Cpha266_0021 2.4e-28 132.1 Bacteria Bacteria 2ATAH@1,31ITJ@2 NA|NA|NA PFHLONEA_00089 1120963.KB894497_gene2189 2.2e-41 175.3 Gammaproteobacteria ko:K21572 ko00000,ko02000 8.A.46.1,8.A.46.3 Bacteria 1N2JT@1224,1S9TE@1236,COG2913@1,COG2913@2 NA|NA|NA J Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane PFHLONEA_00090 1122221.JHVI01000002_gene787 9.7e-16 92.4 Bacteria 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 R06200,R11307,R11308 ko00000,ko00001,ko01000 GH5,GH9 Bacteria COG4447@1,COG4447@2 NA|NA|NA S cellulose binding PFHLONEA_00091 555779.Dthio_PD1786 1.8e-17 95.9 Deltaproteobacteria 1.1.1.412,5.1.3.26 ko:K19997,ko:K22320 ko00000,ko01000 Bacteria 1R0WU@1224,2WTRM@28221,42ZB4@68525,COG0451@1,COG0451@2,COG0664@1,COG0664@2 NA|NA|NA GM epimerase dehydratase PFHLONEA_00092 1169144.KB910924_gene443 3.7e-58 231.5 Bacillus Bacteria 1UB2C@1239,1ZCRA@1386,4HB26@91061,COG2258@1,COG2258@2 NA|NA|NA S protein conserved in bacteria PFHLONEA_00093 580332.Slit_2237 1.7e-111 409.1 Nitrosomonadales ytfG GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.6.5.2 ko:K19267 ko00130,ko01110,map00130,map01110 R02964,R03643,R03816 RC00819 ko00000,ko00001,ko01000 Bacteria 1MW44@1224,2VM5Q@28216,44WCW@713636,COG0702@1,COG0702@2 NA|NA|NA GM NmrA-like family PFHLONEA_00094 102129.Lepto7375DRAFT_0197 7.2e-08 62.4 Bacteria Bacteria COG1680@1,COG1680@2 NA|NA|NA V peptidase activity PFHLONEA_00096 933262.AXAM01000009_gene1487 2.8e-11 75.9 Desulfobacterales ko:K06940 ko00000 Bacteria 1RCRP@1224,2MJI3@213118,2WMQD@28221,42QP5@68525,COG0727@1,COG0727@2 NA|NA|NA S Putative zinc- or iron-chelating domain PFHLONEA_00098 1121403.AUCV01000020_gene3084 9.3e-14 85.5 Bacteria pilV GO:0003674,GO:0005198,GO:0005575,GO:0005623,GO:0008150,GO:0009289,GO:0009405,GO:0009987,GO:0016043,GO:0030030,GO:0042995,GO:0044419,GO:0044464,GO:0051704,GO:0071840 ko:K02457,ko:K02458,ko:K10926,ko:K10930,ko:K10931 ko03070,ko05110,ko05111,map03070,map05110,map05111 M00331 ko00000,ko00001,ko00002,ko02044 3.A.15 Bacteria COG1572@1,COG1572@2,COG2165@1,COG2165@2 NA|NA|NA NU bacterial-type flagellum-dependent cell motility PFHLONEA_00099 96561.Dole_3024 5.3e-112 412.9 Desulfobacterales ko:K11935 ko02026,map02026 ko00000,ko00001 Bacteria 1PE62@1224,2MP74@213118,2X25C@28221,43768@68525,COG3386@1,COG3386@2,COG3391@1,COG3391@2,COG4783@1,COG4783@2 NA|NA|NA G chaperone-mediated protein folding PFHLONEA_00101 555779.Dthio_PD3236 6.4e-25 120.2 Desulfovibrionales bamH 1.12.1.3,1.6.5.3 ko:K00335,ko:K18331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 iAF987.Gmet_2080 Bacteria 1MV8F@1224,2M833@213115,2WJ1W@28221,42N6N@68525,COG1894@1,COG1894@2 NA|NA|NA C PFAM Respiratory-chain NADH dehydrogenase domain 51 kDa subunit PFHLONEA_00102 555779.Dthio_PD3234 2.8e-24 119.0 Bacteria Bacteria COG1894@1,COG1894@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain PFHLONEA_00103 555779.Dthio_PD3233 5.7e-119 435.3 delta/epsilon subdivisions sfrA GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0044237,GO:0044424,GO:0044464,GO:0045333,GO:0048037,GO:0051536,GO:0051540,GO:0055114,GO:0071944 1.17.1.10,1.17.1.9,1.6.5.3 ko:K00123,ko:K00336,ko:K05299 ko00190,ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00190,map00630,map00680,map00720,map01100,map01120,map01200 M00144,M00377 R00134,R00519,R11945 RC00061,RC02796 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 1QTZB@1224,43D31@68525,COG3383@1,COG3383@2 NA|NA|NA C NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding PFHLONEA_00106 1123368.AUIS01000035_gene84 4.7e-18 97.1 Acidithiobacillales ica2 ko:K11936 ko02026,map02026 ko00000,ko00001,ko01000,ko01003,ko02000 4.D.1.1.2,4.D.1.1.3 GT2 Bacteria 1MXG7@1224,1RMS4@1236,2NC2T@225057,COG1215@1,COG1215@2 NA|NA|NA M Chitin synthase PFHLONEA_00108 269797.Mbar_A3542 2.7e-88 332.4 Methanomicrobia comE GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006790,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019295,GO:0019296,GO:0019842,GO:0030976,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0048037,GO:0050545,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:1901363,GO:1901576,GO:1901681 4.1.1.79,4.1.1.82 ko:K09459,ko:K13039 ko00440,ko00680,ko01100,ko01120,ko01130,map00440,map00680,map01100,map01120,map01130 M00358 R04053,R05774 RC00506 ko00000,ko00001,ko00002,ko01000 Archaea 2N9BM@224756,2XVNH@28890,COG4032@1,arCOG01614@2157 NA|NA|NA G Thiamine pyrophosphate enzyme, N-terminal TPP binding domain PFHLONEA_00109 521011.Mpal_2734 2e-92 346.3 Methanomicrobia 2.5.1.76 ko:K15527 ko00000,ko01000 Archaea 2N9BY@224756,2XUJC@28890,COG0498@1,arCOG01434@2157 NA|NA|NA H Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate PFHLONEA_00110 756499.Desde_0778 6.4e-28 130.6 Peptococcaceae 1.8.98.1 ko:K08264 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 R04540 RC00011 ko00000,ko00001,ko01000 Bacteria 1TPG1@1239,24HJC@186801,264WD@186807,COG0247@1,COG0247@2 NA|NA|NA C 4Fe-4S dicluster domain PFHLONEA_00111 237368.SCABRO_00631 3.2e-65 255.0 Planctomycetes hyfE GO:0008150,GO:0040007 ko:K12140 ko00000,ko01000 Bacteria 2J10M@203682,COG4237@1,COG4237@2 NA|NA|NA C Hydrogenase 4 membrane PFHLONEA_00112 237368.SCABRO_00630 3e-109 401.7 Planctomycetes hycD Bacteria 2IZN2@203682,COG0650@1,COG0650@2 NA|NA|NA C NADH dehydrogenase PFHLONEA_00113 237368.SCABRO_00629 2e-54 219.2 Planctomycetes hyfB GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K12137,ko:K15828 ko00000,ko01000 iB21_1397.B21_02538,iECBD_1354.ECBD_1002,iECB_1328.ECB_02573,iECD_1391.ECD_02573,iECED1_1282.ECED1_3174,iECO111_1330.ECO111_3443,iECO26_1355.ECO26_3788,iECP_1309.ECP_2686,iEKO11_1354.EKO11_1252,iEcHS_1320.EcHS_A2859,iLF82_1304.LF82_1065,iNRG857_1313.NRG857_13330 Bacteria 2IZ03@203682,COG0651@1,COG0651@2 NA|NA|NA CP Proton-conducting membrane transporter PFHLONEA_00114 243231.GSU2206 1.4e-11 75.5 Desulfuromonadales rpsT GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030234,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0042979,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050790,GO:0065003,GO:0065007,GO:0065009,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02968 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1NITA@1224,2WR9I@28221,42V4U@68525,43VI5@69541,COG0268@1,COG0268@2 NA|NA|NA J Binds directly to 16S ribosomal RNA PFHLONEA_00115 1499967.BAYZ01000182_gene4417 1.1e-48 200.7 unclassified Bacteria holA 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 2NPN5@2323,COG1466@1,COG1466@2 NA|NA|NA L DNA polymerase III delta subunit PFHLONEA_00116 1131269.AQVV01000012_gene2603 4.2e-18 98.2 Bacteria lptE GO:0001530,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0008289,GO:0009279,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044462,GO:0044464,GO:0045229,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071709,GO:0071840,GO:0071944,GO:0097367,GO:1901264 ko:K03643 ko00000,ko02000 1.B.42.1 iECH74115_1262.ECH74115_0730,iECSP_1301.ECSP_0694,iECs_1301.ECs0679,iG2583_1286.G2583_0804,iZ_1308.Z0788 Bacteria COG2980@1,COG2980@2 NA|NA|NA M Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane PFHLONEA_00117 269799.Gmet_2300 0.0 1107.8 Desulfuromonadales leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 iAF987.Gmet_2300 Bacteria 1MV47@1224,2WJ3E@28221,42MRQ@68525,43TD1@69541,COG0495@1,COG0495@2 NA|NA|NA J leucyl-tRNA aminoacylation PFHLONEA_00119 316067.Geob_2156 1.3e-129 469.9 Desulfuromonadales der ko:K03977 ko00000,ko03009 Bacteria 1MU9S@1224,2WISS@28221,42M3N@68525,43U5B@69541,COG1160@1,COG1160@2 NA|NA|NA J GTPase that plays an essential role in the late steps of ribosome biogenesis PFHLONEA_00120 443143.GM18_3187 8.6e-22 109.0 Deltaproteobacteria cspA ko:K03704 ko00000,ko03000 Bacteria 1N6Q5@1224,2WR92@28221,42V0K@68525,COG1278@1,COG1278@2 NA|NA|NA K PFAM Cold-shock protein, DNA-binding PFHLONEA_00121 1304885.AUEY01000011_gene1728 1e-82 313.5 Desulfobacterales rpfG Bacteria 1MUB8@1224,2MNAV@213118,2WNXG@28221,42QYY@68525,COG3437@1,COG3437@2 NA|NA|NA KT HD domain PFHLONEA_00122 929556.Solca_1935 7.4e-120 438.3 Bacteroidetes Bacteria 4NFN0@976,COG5164@1,COG5164@2 NA|NA|NA K regulation of DNA-templated transcription, elongation PFHLONEA_00123 1298867.AUES01000041_gene905 9.4e-07 60.1 Alphaproteobacteria ko:K03886 ko00190,ko01100,map00190,map01100 M00151 ko00000,ko00001,ko00002,ko01000 Bacteria 1QW30@1224,2UFA0@28211,COG1873@1,COG1873@2 NA|NA|NA S PFAM PRC-barrel domain PFHLONEA_00124 398579.Spea_0869 4.1e-25 121.7 Shewanellaceae VP2042 Bacteria 1RICQ@1224,1SF8S@1236,2QBM3@267890,COG3637@1,COG3637@2 NA|NA|NA M Outer membrane protein beta-barrel domain PFHLONEA_00129 667014.Thein_0190 1.3e-51 209.9 Thermodesulfobacteria fliA ko:K02405,ko:K03093 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 ko00000,ko00001,ko02035,ko03021 Bacteria 2GHGC@200940,COG1191@1,COG1191@2 NA|NA|NA K Sigma-70, region 4 PFHLONEA_00130 289376.THEYE_A2073 2.1e-69 269.2 Nitrospirae flhG ko:K02282,ko:K04562 ko00000,ko02035,ko02044 Bacteria 3J0JR@40117,COG0455@1,COG0455@2 NA|NA|NA D Cellulose biosynthesis protein BcsQ PFHLONEA_00131 667014.Thein_1806 1.6e-133 483.0 Thermodesulfobacteria fleQ ko:K10941 ko02020,ko02025,ko05111,map02020,map02025,map05111 ko00000,ko00001,ko03000 Bacteria 2GHIR@200940,COG2204@1,COG2204@2 NA|NA|NA T Bacterial regulatory protein, Fis family PFHLONEA_00134 330214.NIDE0999 8.8e-147 526.6 Nitrospirae ilvC 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS10005,iHN637.CLJU_RS10010,iJN746.PP_4678,iLJ478.TM0550 Bacteria 3J0DW@40117,COG0059@1,COG0059@2 NA|NA|NA H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate PFHLONEA_00135 1131269.AQVV01000018_gene1893 8e-53 213.8 Bacteria psd 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 Bacteria COG0688@1,COG0688@2 NA|NA|NA I phosphatidylethanolamine metabolic process PFHLONEA_00136 443143.GM18_2609 4.5e-55 221.5 Desulfuromonadales pssA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 Bacteria 1MWD9@1224,2WMR6@28221,42QV4@68525,43SK7@69541,COG1183@1,COG1183@2 NA|NA|NA I Belongs to the CDP-alcohol phosphatidyltransferase class-I family PFHLONEA_00137 1504672.669785865 3.9e-69 268.1 Comamonadaceae hlyIII ko:K11068 ko00000,ko02042 Bacteria 1PGRH@1224,2VJR4@28216,4ADHB@80864,COG1272@1,COG1272@2 NA|NA|NA S PFAM Hly-III family protein PFHLONEA_00138 330214.NIDE1347 1.8e-11 74.7 Bacteria racA ko:K11686,ko:K13640,ko:K18997 ko00000,ko03000,ko03036 Bacteria COG0789@1,COG0789@2 NA|NA|NA K bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding PFHLONEA_00139 1499967.BAYZ01000068_gene1962 1.4e-91 343.2 unclassified Bacteria pilM ko:K02662 ko00000,ko02035,ko02044 Bacteria 2NPF6@2323,COG4972@1,COG4972@2 NA|NA|NA NU Type IV pilus assembly protein PilM; PFHLONEA_00140 330214.NIDE1349 3e-16 92.0 Nitrospirae pilN ko:K02663 ko00000,ko02035,ko02044 Bacteria 3J1EX@40117,COG3166@1,COG3166@2 NA|NA|NA NU Fimbrial assembly protein (PilN) PFHLONEA_00141 330214.NIDE1350 8.5e-23 114.0 Nitrospirae pilO ko:K02664 ko00000,ko02035,ko02044 Bacteria 3J1BH@40117,COG3167@1,COG3167@2 NA|NA|NA NU Pilus assembly protein, PilO PFHLONEA_00142 330214.NIDE1351 1.4e-20 106.3 Nitrospirae pilP ko:K02664,ko:K02665 ko00000,ko02035,ko02044 Bacteria 3J1AT@40117,COG3168@1,COG3168@2 NA|NA|NA NU Pilus assembly protein, PilP PFHLONEA_00143 290397.Adeh_0645 2.9e-108 399.8 Myxococcales pilQ ko:K02666 ko00000,ko02035,ko02044 3.A.15.2 Bacteria 1QTT6@1224,2WJV6@28221,2YTV4@29,42MKN@68525,COG4796@1,COG4796@2 NA|NA|NA U type IV pilus secretin PilQ PFHLONEA_00145 1232410.KI421426_gene1494 6.5e-137 494.2 Desulfuromonadales echA ko:K14086 ko00000 Bacteria 1MW2M@1224,2WIWK@28221,42KZE@68525,43TMM@69541,COG1009@1,COG1009@2 NA|NA|NA CP NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus PFHLONEA_00147 909663.KI867149_gene3436 1.9e-23 116.7 Syntrophobacterales Bacteria 1PGQF@1224,2MSB0@213462,2X37N@28221,43F38@68525,COG3209@1,COG3209@2 NA|NA|NA M COG3209 Rhs family protein PFHLONEA_00148 398767.Glov_2151 2.9e-16 92.4 Desulfuromonadales pilX-2 Bacteria 1NY0D@1224,2E6Z6@1,2WVKD@28221,331IC@2,430VK@68525,43VJN@69541 NA|NA|NA PFHLONEA_00149 243231.GSU2035 1.9e-56 226.5 Desulfuromonadales pilW-2 ko:K02456,ko:K02672 ko03070,ko05111,map03070,map05111 M00331 ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15 Bacteria 1REDT@1224,2WNPG@28221,42RY5@68525,43V26@69541,COG4968@1,COG4968@2 NA|NA|NA NU Prokaryotic N-terminal methylation motif PFHLONEA_00150 1382306.JNIM01000001_gene3449 1.8e-15 89.0 Chloroflexi MA20_45160 ko:K13993 ko04141,map04141 ko00000,ko00001,ko03110 Bacteria 2G7BB@200795,COG0071@1,COG0071@2 NA|NA|NA O Belongs to the small heat shock protein (HSP20) family PFHLONEA_00151 639282.DEFDS_1186 2.9e-34 151.8 Deferribacteres lspA 3.4.23.36 ko:K03101 ko03060,map03060 ko00000,ko00001,ko01000,ko01002 Bacteria 2GFR7@200930,COG0597@1,COG0597@2 NA|NA|NA M This protein specifically catalyzes the removal of signal peptides from prolipoproteins PFHLONEA_00152 439235.Dalk_1768 4.6e-66 258.1 Desulfobacterales lgt ko:K13292 ko00000,ko01000 Bacteria 1MVE3@1224,2MIZH@213118,2WNPT@28221,42M2I@68525,COG0682@1,COG0682@2 NA|NA|NA M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins PFHLONEA_00154 269799.Gmet_0837 1e-37 162.9 Deltaproteobacteria iorB 1.3.99.16 ko:K07303 ko00000,ko01000 Bacteria 1QTTJ@1224,2WKXG@28221,42NU9@68525,COG1529@1,COG1529@2 NA|NA|NA C Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding PFHLONEA_00155 204669.Acid345_2647 3.5e-56 225.3 Acidobacteriia pucA ko:K07402 ko00000 Bacteria 2JP44@204432,3Y54Y@57723,COG1975@1,COG1975@2 NA|NA|NA C XdhC and CoxI family PFHLONEA_00156 269799.Gmet_0836 2.6e-36 158.7 Desulfuromonadales mocA GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019538,GO:0019637,GO:0019720,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061602,GO:0070567,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902759,GO:1902760 1.1.1.328,2.7.7.76 ko:K07141,ko:K19190 ko00760,ko00790,ko01120,map00760,map00790,map01120 R10131,R10132,R11582 RC03053 ko00000,ko00001,ko01000 iAPECO1_1312.APECO1_3649,iB21_1397.B21_02672,iECABU_c1320.ECABU_c31580,iECBD_1354.ECBD_0860,iECB_1328.ECB_02710,iECD_1391.ECD_02710,iEcHS_1320.EcHS_A3037 Bacteria 1RAAE@1224,2WMYX@28221,42QNZ@68525,43V5W@69541,COG2068@1,COG2068@2 NA|NA|NA S 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase PFHLONEA_00157 485915.Dret_0687 4.5e-11 73.6 Desulfovibrionales Bacteria 1NGC1@1224,2MD4Z@213115,2WRAY@28221,42W5D@68525,COG2331@1,COG2331@2 NA|NA|NA S TIGRFAM regulatory protein, FmdB PFHLONEA_00158 671143.DAMO_1931 7e-70 271.6 unclassified Bacteria Bacteria 2NPKK@2323,COG1538@1,COG1538@2 NA|NA|NA MU Outer membrane efflux protein PFHLONEA_00160 269799.Gmet_1447 3e-71 275.4 Desulfuromonadales ywqD 2.7.10.1 ko:K08252 ko00000,ko01000 Bacteria 1MVI9@1224,2WMX0@28221,42QS3@68525,43T36@69541,COG0489@1,COG0489@2 NA|NA|NA D AAA domain PFHLONEA_00161 269799.Gmet_1446 8.2e-87 327.4 Desulfuromonadales ko:K07011,ko:K16706 ko00000 Bacteria 1MVBX@1224,2WKRC@28221,42PYQ@68525,43SUS@69541,COG3206@1,COG3206@2 NA|NA|NA M Chain length determinant protein PFHLONEA_00164 330214.NIDE0398 5.5e-156 557.8 Nitrospirae pheS GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 3J0SW@40117,COG0016@1,COG0016@2 NA|NA|NA J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type PFHLONEA_00165 1121472.AQWN01000002_gene2117 1.2e-09 69.7 Peptococcaceae Bacteria 1W10Z@1239,253TJ@186801,265X5@186807,2FH83@1,3492G@2 NA|NA|NA PFHLONEA_00167 483219.LILAB_25485 3.2e-10 72.4 Myxococcales ftsN ko:K03591,ko:K03749 ko00000,ko03036 Bacteria 1MYFG@1224,2WSPI@28221,2Z3GD@29,42X25@68525,COG3087@1,COG3087@2 NA|NA|NA D Sporulation related domain PFHLONEA_00168 648996.Theam_1729 3.4e-37 161.0 Aquificae queA GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 ko:K07568 ko00000,ko01000,ko03016 Bacteria 2G3KG@200783,COG0809@1,COG0809@2 NA|NA|NA J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) PFHLONEA_00170 243231.GSU1762 1.2e-53 217.2 Desulfuromonadales Bacteria 1QXNU@1224,2X7F5@28221,43C4R@68525,43SFM@69541,COG0457@1,COG0457@2 NA|NA|NA S Peptidase MA superfamily PFHLONEA_00172 697281.Mahau_0162 3.3e-24 117.5 Thermoanaerobacterales yaaK ko:K09747 ko00000 Bacteria 1VA1S@1239,24MXH@186801,42GPV@68295,COG0718@1,COG0718@2 NA|NA|NA L Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection PFHLONEA_00173 398512.JQKC01000002_gene1974 7.8e-59 233.8 Ruminococcaceae recR GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 ko:K06187 ko03440,map03440 ko00000,ko00001,ko03400 Bacteria 1TR87@1239,2487H@186801,3WHNZ@541000,COG0353@1,COG0353@2 NA|NA|NA L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO PFHLONEA_00174 1123376.AUIU01000014_gene654 2.9e-78 298.1 Nitrospirae porC 1.2.7.1 ko:K00172 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 3J0TG@40117,COG1014@1,COG1014@2 NA|NA|NA C Pyruvate ferredoxin/flavodoxin oxidoreductase PFHLONEA_00175 289376.THEYE_A0908 2e-35 154.8 Bacteria porD 1.2.7.1 ko:K00171,ko:K00172 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria COG1144@1,COG1144@2 NA|NA|NA C oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor PFHLONEA_00177 338963.Pcar_2142 1.2e-81 309.7 Desulfuromonadales pilH ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1MUX3@1224,2WJXQ@28221,42NSM@68525,43RXP@69541,COG1131@1,COG1131@2 NA|NA|NA V PFAM ABC transporter related PFHLONEA_00178 338963.Pcar_2141 1.1e-80 306.6 Desulfuromonadales pilI Bacteria 1RM0H@1224,2WPQJ@28221,42T8A@68525,43VJG@69541,COG1277@1,COG1277@2 NA|NA|NA S ABC-2 family transporter protein PFHLONEA_00180 330214.NIDE0795 4.7e-81 307.8 Nitrospirae fabH 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 3J0FW@40117,COG0332@1,COG0332@2 NA|NA|NA I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids PFHLONEA_00181 289376.THEYE_A1041 1.5e-74 287.0 Nitrospirae ko:K07277 ko00000,ko02000,ko03029 1.B.33 Bacteria 3J0AC@40117,COG4775@1,COG4775@2 NA|NA|NA M Surface antigen PFHLONEA_00182 316274.Haur_4259 1.1e-33 151.8 Chloroflexia 2.7.13.3 ko:K02482 ko00000,ko01000,ko01001,ko02022 Bacteria 2G7Y4@200795,374VX@32061,COG0745@1,COG0745@2,COG0784@1,COG0784@2,COG2203@1,COG2203@2,COG4191@1,COG4191@2 NA|NA|NA T histidine kinase A domain protein PFHLONEA_00183 525897.Dbac_0989 3.1e-10 72.4 Desulfovibrionales 5.2.1.8 ko:K01802,ko:K03771 ko00000,ko01000,ko03110 Bacteria 1MVB3@1224,2M8YR@213115,2WMN3@28221,42QXH@68525,COG0760@1,COG0760@2 NA|NA|NA M peptidylprolyl isomerase PFHLONEA_00184 247490.KSU1_C0729 4.4e-76 291.6 Planctomycetes sppA ko:K04773 ko00000,ko01000,ko01002 Bacteria 2IYKF@203682,COG0616@1,COG0616@2 NA|NA|NA OU TIGRFAM signal peptide peptidase SppA, 36K type PFHLONEA_00185 350058.Mvan_2912 2.3e-36 159.5 Mycobacteriaceae Bacteria 235TR@1762,2GJ78@201174,COG2267@1,COG2267@2 NA|NA|NA I Alpha beta hydrolase PFHLONEA_00187 398767.Glov_2680 1.8e-128 466.5 Deltaproteobacteria recN GO:0000724,GO:0000725,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009295,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0030312,GO:0031668,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071944,GO:0090304,GO:1901360 ko:K03631,ko:K13582 ko04112,map04112 ko00000,ko00001,ko03400 Bacteria 1MUNP@1224,2WJ23@28221,42N50@68525,COG0497@1,COG0497@2 NA|NA|NA L May be involved in recombinational repair of damaged DNA PFHLONEA_00188 1408422.JHYF01000004_gene1614 1.5e-13 81.6 Clostridiaceae vorD 1.2.7.3 ko:K00176 ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200 M00009,M00011,M00173,M00620 R01197 RC00004,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1VETY@1239,25E51@186801,36NCT@31979,COG1146@1,COG1146@2 NA|NA|NA C 4Fe-4S dicluster domain PFHLONEA_00192 269799.Gmet_3519 1.8e-118 432.2 Desulfuromonadales ttrB ko:K08358 ko00920,ko01120,ko02020,map00920,map01120,map02020 R10150 RC03109 ko00000,ko00001,ko02000 5.A.3.10 Bacteria 1MU1B@1224,2WMS4@28221,42QZ2@68525,43T2N@69541,COG0437@1,COG0437@2 NA|NA|NA C 4Fe-4S dicluster domain PFHLONEA_00193 269799.Gmet_3518 3.2e-59 234.6 Desulfuromonadales Bacteria 1NCE1@1224,2EE9W@1,2WSA1@28221,3384B@2,42VUH@68525,43V30@69541 NA|NA|NA C Menaquinol oxidoreductase complex Cbc4, cytochrome c subunit PFHLONEA_00195 269799.Gmet_3357 1.2e-12 79.0 Desulfuromonadales atpI ko:K02116 ko00000,ko00194 3.A.2.1 Bacteria 1NHIS@1224,2WSRU@28221,42WTD@68525,43VEC@69541,COG5336@1,COG5336@2 NA|NA|NA S Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter PFHLONEA_00196 395495.Lcho_3832 1.7e-95 355.9 unclassified Burkholderiales lnt ko:K03820 ko00000,ko01000 GT2 Bacteria 1KJ0S@119065,1MUBU@1224,2VH1I@28216,COG0815@1,COG0815@2 NA|NA|NA M Transfers the fatty acyl group on membrane lipoproteins PFHLONEA_00197 443143.GM18_2451 3.6e-15 87.4 Bacteria atpF ko:K02122 ko00190,ko01100,map00190,map01100 M00159 ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 Bacteria COG1436@1,COG1436@2 NA|NA|NA C Produces ATP from ADP in the presence of a proton gradient across the membrane PFHLONEA_00198 443143.GM18_2452 4.6e-198 697.6 Desulfuromonadales atpA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0034220,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044464,GO:0044769,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132,GO:1902600 3.6.3.14,3.6.3.15 ko:K02117 ko00190,ko01100,map00190,map01100 M00159 ko00000,ko00001,ko00002,ko01000 3.A.2.2,3.A.2.3 Bacteria 1MWRR@1224,2WIQQ@28221,42NKK@68525,43UIJ@69541,COG1155@1,COG1155@2 NA|NA|NA C ATPsynthase alpha/beta subunit N-term extension PFHLONEA_00199 443143.GM18_2453 3.9e-171 607.8 Desulfuromonadales atpB ko:K02118 ko00190,ko01100,map00190,map01100 M00159 ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 Bacteria 1R4RB@1224,2WJB9@28221,42PJC@68525,43SZ6@69541,COG1156@1,COG1156@2 NA|NA|NA C ATP synthase alpha/beta family, nucleotide-binding domain PFHLONEA_00201 290397.Adeh_0109 1.8e-39 169.9 Deltaproteobacteria Bacteria 1NJEJ@1224,2WK76@28221,42NQM@68525,COG2864@1,COG2864@2,COG3005@1,COG3005@2 NA|NA|NA C denitrification pathway PFHLONEA_00202 404589.Anae109_0113 3e-48 198.7 Deltaproteobacteria Bacteria 1NJEJ@1224,2WK76@28221,42NQM@68525,COG2864@1,COG2864@2,COG3005@1,COG3005@2 NA|NA|NA C denitrification pathway PFHLONEA_00203 1499967.BAYZ01000171_gene5600 1.8e-26 125.9 unclassified Bacteria ko:K13993 ko04141,map04141 ko00000,ko00001,ko03110 Bacteria 2NPWF@2323,COG0071@1,COG0071@2 NA|NA|NA O Belongs to the small heat shock protein (HSP20) family PFHLONEA_00204 1232410.KI421424_gene1720 1.9e-80 306.2 Desulfuromonadales hrcA GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 ko:K03705 ko00000,ko03000 Bacteria 1MVX4@1224,2WIXW@28221,42MTI@68525,43S42@69541,COG1420@1,COG1420@2 NA|NA|NA K HrcA protein C terminal domain PFHLONEA_00205 338963.Pcar_0108 5e-28 131.3 Desulfuromonadales grpE GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0017076,GO:0030234,GO:0030312,GO:0030554,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036094,GO:0040007,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0050896,GO:0051082,GO:0051716,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0071496,GO:0071944,GO:0097159,GO:0098772,GO:1901265,GO:1901363 ko:K03687 ko00000,ko03029,ko03110 Bacteria 1RH8T@1224,2WQ0U@28221,42TM2@68525,43US5@69541,COG0576@1,COG0576@2 NA|NA|NA O GrpE PFHLONEA_00207 1232410.KI421426_gene1483 1.9e-39 168.7 Deltaproteobacteria Bacteria 1Q0W8@1224,29WX2@1,2WXEY@28221,30IJ3@2,433PA@68525 NA|NA|NA S Cysteine rich repeat PFHLONEA_00208 1177179.A11A3_09835 1.3e-27 130.2 Gammaproteobacteria Bacteria 1RI4B@1224,1S8IK@1236,COG3637@1,COG3637@2 NA|NA|NA M Outer membrane protein beta-barrel domain PFHLONEA_00209 1232410.KI421426_gene1483 1.5e-39 169.1 Deltaproteobacteria Bacteria 1Q0W8@1224,29WX2@1,2WXEY@28221,30IJ3@2,433PA@68525 NA|NA|NA S Cysteine rich repeat PFHLONEA_00210 335543.Sfum_1463 1e-19 102.8 Bacteria ycnE GO:0003674,GO:0003824 3.1.1.29 ko:K01056 ko00000,ko01000,ko03012 Bacteria COG1359@1,COG1359@2 NA|NA|NA S Antibiotic biosynthesis monooxygenase PFHLONEA_00211 335543.Sfum_1464 1.5e-93 349.4 Syntrophobacterales 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 ko00000,ko00001,ko01000,ko02035 Bacteria 1NU8B@1224,2MR33@213462,2WIW6@28221,42MEA@68525,COG2202@1,COG2202@2,COG3829@1,COG3829@2 NA|NA|NA KT Domain present in phytochromes and cGMP-specific phosphodiesterases. PFHLONEA_00212 1499967.BAYZ01000156_gene561 1.7e-26 125.6 unclassified Bacteria hspR GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 ko:K13640 ko00000,ko03000 Bacteria 2NPTR@2323,COG0789@1,COG0789@2 NA|NA|NA K Transcriptional regulator, MerR family PFHLONEA_00213 264732.Moth_0586 1.7e-93 349.7 Thermoanaerobacterales dnaJ ko:K03686 ko00000,ko03029,ko03110 Bacteria 1TP00@1239,248EM@186801,42ESV@68295,COG0484@1,COG0484@2 NA|NA|NA O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins PFHLONEA_00214 1121422.AUMW01000029_gene27 2.1e-22 112.8 Clostridia Bacteria 1VFIG@1239,24STM@186801,COG1413@1,COG1413@2 NA|NA|NA C lyase activity PFHLONEA_00215 243231.GSU2724 9.7e-43 180.6 Bacteria Bacteria 2DVSV@1,33X1K@2 NA|NA|NA PFHLONEA_00216 443143.GM18_3462 5.5e-37 160.6 Bacteria Bacteria 2DX02@1,342QW@2 NA|NA|NA PFHLONEA_00217 522772.Dacet_0935 3.6e-84 318.9 Bacteria Bacteria 2EUXR@1,33ND1@2 NA|NA|NA PFHLONEA_00221 153721.MYP_3119 1.1e-58 233.0 Cytophagia 1.5.1.3 ko:K00287 ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523 M00126,M00840 R00936,R00937,R00939,R00940,R02235,R02236,R11765 RC00109,RC00110,RC00158 ko00000,ko00001,ko00002,ko01000 Bacteria 47RPC@768503,4NPX6@976,COG0262@1,COG0262@2 NA|NA|NA H RibD C-terminal domain PFHLONEA_00222 1255043.TVNIR_3515 1.6e-44 186.0 Gammaproteobacteria 1.5.1.3 ko:K00287 ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523 M00126,M00840 R00936,R00937,R00939,R00940,R02235,R02236,R11765 RC00109,RC00110,RC00158 ko00000,ko00001,ko00002,ko01000 Bacteria 1R5UU@1224,1SEMI@1236,COG0262@1,COG0262@2 NA|NA|NA H RibD C-terminal domain PFHLONEA_00223 909663.KI867151_gene3153 3.5e-169 601.3 Deltaproteobacteria yqxK 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 1QYWZ@1224,2X7PS@28221,43CDU@68525,COG1379@1,COG1379@2 NA|NA|NA PFHLONEA_00227 289376.THEYE_A1303 2.1e-118 432.2 Nitrospirae 1.11.1.5 ko:K00428 ko00000,ko01000 Bacteria 3J0GH@40117,COG1858@1,COG1858@2 NA|NA|NA C Di-haem cytochrome c peroxidase PFHLONEA_00228 161156.JQKW01000011_gene979 5.4e-30 138.3 Thermodesulfobacteria fdhE GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006807,GO:0008150,GO:0008152,GO:0008199,GO:0009061,GO:0009987,GO:0010467,GO:0015980,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046872,GO:0046914,GO:0051604,GO:0055114,GO:0071704,GO:1901564 ko:K02380 ko00000 Bacteria 2GHRU@200940,COG3058@1,COG3058@2 NA|NA|NA O Protein involved in formate dehydrogenase formation PFHLONEA_00230 1379698.RBG1_1C00001G0753 2.8e-98 365.5 unclassified Bacteria rtcA GO:0003674,GO:0003824,GO:0003963,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009975,GO:0016874,GO:0016886,GO:0044424,GO:0044464,GO:0140098 6.5.1.4 ko:K01974 ko00000,ko01000 Bacteria 2NP9K@2323,COG0430@1,COG0430@2 NA|NA|NA A Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP PFHLONEA_00232 243231.GSU2724 1.2e-35 157.5 Bacteria Bacteria 2DVSV@1,33X1K@2 NA|NA|NA PFHLONEA_00234 243231.GSU2794 4.8e-49 200.7 Desulfuromonadales mscL GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 ko:K03282 ko00000,ko02000 1.A.22.1 Bacteria 1RHG8@1224,2WP7G@28221,42RNC@68525,43V0M@69541,COG1970@1,COG1970@2 NA|NA|NA C Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell PFHLONEA_00235 1158292.JPOE01000002_gene3200 1.2e-28 132.9 unclassified Burkholderiales yidB Bacteria 1KMJG@119065,1N7FF@1224,2VVTK@28216,COG3753@1,COG3753@2 NA|NA|NA S Bacterial protein of unknown function (DUF937) PFHLONEA_00236 909663.KI867150_gene1399 3.4e-21 107.5 Syntrophobacterales Bacteria 1NBYG@1224,2CFNS@1,2MS7D@213462,2WR8A@28221,331AJ@2,42VZ5@68525 NA|NA|NA PFHLONEA_00237 335543.Sfum_2038 4e-19 100.5 Syntrophobacterales comEA ko:K02237 M00429 ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 Bacteria 1Q2CD@1224,2MSET@213462,2X38P@28221,437YR@68525,COG1555@1,COG1555@2 NA|NA|NA L Helix-hairpin-helix motif PFHLONEA_00238 316067.Geob_1586 3.2e-46 191.8 Desulfuromonadales thiE GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3,2.7.1.49,2.7.4.7 ko:K00788,ko:K14153 ko00730,ko01100,map00730,map01100 M00127 R03223,R03471,R04509,R10712 RC00002,RC00017,RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 Bacteria 1RDSU@1224,2WQME@28221,42NTP@68525,43UPN@69541,COG0352@1,COG0352@2 NA|NA|NA H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) PFHLONEA_00239 330214.NIDE3060 6.9e-115 420.2 Nitrospirae thiG GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.10 ko:K03149 ko00730,ko01100,map00730,map01100 R10247 RC03096,RC03097,RC03461 ko00000,ko00001,ko01000 Bacteria 3J0EI@40117,COG2022@1,COG2022@2 NA|NA|NA H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S PFHLONEA_00240 1121451.DESAM_21865 9.3e-09 65.9 Desulfovibrionales thiS ko:K03154 ko04122,map04122 ko00000,ko00001 Bacteria 1NG8E@1224,2MDTU@213115,2WSM2@28221,42WUA@68525,COG2104@1,COG2104@2 NA|NA|NA H thiamine biosynthesis protein ThiS PFHLONEA_00241 398767.Glov_3084 1.4e-46 193.0 Desulfuromonadales cobC 3.1.3.3,3.1.3.73,3.1.3.85 ko:K02226,ko:K22305,ko:K22306 ko00260,ko00680,ko00860,ko01100,ko01120,ko01130,map00260,map00680,map00860,map01100,map01120,map01130 M00122 R00582,R04594,R11173 RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 1RHAT@1224,2WP5H@28221,42SUD@68525,43UKX@69541,COG0406@1,COG0406@2 NA|NA|NA G Phosphoglycerate mutase family PFHLONEA_00242 748449.Halha_1701 3.4e-34 152.1 Halanaerobiales cobS 2.7.8.26 ko:K02233 ko00860,ko01100,map00860,map01100 M00122 R05223,R11174 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 Bacteria 1V1QB@1239,24I0D@186801,3WC3I@53433,COG0368@1,COG0368@2 NA|NA|NA H Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate PFHLONEA_00243 316067.Geob_0539 1.6e-57 229.2 Deltaproteobacteria cobT GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008939,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.21 ko:K00768 ko00860,ko01100,map00860,map01100 M00122 R04148 RC00033,RC00063 ko00000,ko00001,ko00002,ko01000 Bacteria 1MVAM@1224,2WJIR@28221,42M3Z@68525,COG2038@1,COG2038@2 NA|NA|NA F Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) PFHLONEA_00249 335543.Sfum_2277 5.8e-24 117.5 Deltaproteobacteria Bacteria 1ND14@1224,2E6ZZ@1,2WT8C@28221,331J0@2,42XQ9@68525 NA|NA|NA PFHLONEA_00250 404380.Gbem_2402 2.8e-124 451.8 Desulfuromonadales purM GO:0003674,GO:0003824,GO:0004641,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.1,6.3.4.13 ko:K01933,ko:K11788 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144,R04208 RC00090,RC00166,RC01100 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1844,iECSF_1327.ECSF_2340 Bacteria 1MURG@1224,2WIXY@28221,42KZT@68525,43RZ8@69541,COG0150@1,COG0150@2 NA|NA|NA F AIR synthase related protein domain protein PFHLONEA_00251 56780.SYN_00888 6e-64 250.8 Syntrophobacterales purN 2.1.2.2,6.3.2.6,6.3.4.13 ko:K11175,ko:K13713 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04144,R04325,R04326,R04591 RC00026,RC00064,RC00090,RC00162,RC00166,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS04225 Bacteria 1MWN1@1224,2MRWI@213462,2WJT0@28221,42R30@68525,COG0299@1,COG0299@2 NA|NA|NA F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate PFHLONEA_00257 929703.KE386492_gene4447 1.4e-80 307.4 Bacteria Bacteria COG1407@1,COG1407@2 NA|NA|NA S Calcineurin-like phosphoesterase PFHLONEA_00258 289376.THEYE_A1061 6.1e-73 281.6 Nitrospirae ccsA GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008152,GO:0015886,GO:0016020,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0055114,GO:0071702,GO:0071705,GO:0071944,GO:1901678 Bacteria 3J0NY@40117,COG0755@1,COG0755@2 NA|NA|NA O Cytochrome C assembly protein PFHLONEA_00259 269799.Gmet_2901 2.9e-77 296.2 Desulfuromonadales resB ko:K07399 ko00000 Bacteria 1N6XE@1224,2WIMD@28221,42NBB@68525,43SZA@69541,COG1333@1,COG1333@2 NA|NA|NA O PFAM ResB family protein PFHLONEA_00261 553175.POREN0001_1730 2.5e-42 179.1 Porphyromonadaceae crt 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 R03026 RC00831 ko00000,ko00001,ko01000 Bacteria 22ZY4@171551,2FWH6@200643,4NFEM@976,COG1024@1,COG1024@2 NA|NA|NA I Belongs to the enoyl-CoA hydratase isomerase family PFHLONEA_00262 330214.NIDE1208 9.2e-08 62.4 Bacteria Bacteria COG2331@1,COG2331@2 NA|NA|NA P Regulatory protein, FmdB family PFHLONEA_00263 1163617.SCD_n00308 6.3e-67 261.2 Betaproteobacteria lpxM GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0019752,GO:0036103,GO:0036104,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0046467,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.241,2.3.1.243 ko:K02517,ko:K02560 ko00540,ko01100,map00540,map01100 M00060 R05075,R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 iECABU_c1320.ECABU_c21170,iECIAI39_1322.ECIAI39_1194,ic_1306.c2269 Bacteria 1MVNI@1224,2VICZ@28216,COG1560@1,COG1560@2 NA|NA|NA M Lipid A Biosynthesis PFHLONEA_00264 484770.UFO1_2005 1.9e-47 196.1 Negativicutes lipM GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 6.3.1.20 ko:K03800 ko00785,ko01100,map00785,map01100 R07770,R07771,R11143 RC00043,RC00070,RC00090,RC00992,RC02896 ko00000,ko00001,ko01000 Bacteria 1TQ5U@1239,4H3KV@909932,COG0095@1,COG0095@2 NA|NA|NA H PFAM biotin lipoate A B protein ligase PFHLONEA_00265 237368.SCABRO_02094 1.7e-110 406.0 Bacteria ybgA Bacteria COG1683@1,COG1683@2,COG3272@1,COG3272@2 NA|NA|NA L Protein of unknown function (DUF1722) PFHLONEA_00266 525897.Dbac_1432 1.5e-36 159.5 Desulfovibrionales Bacteria 1R5EN@1224,2MH9G@213115,2WMCQ@28221,42NK9@68525,COG0745@1,COG0745@2,COG5002@1,COG5002@2 NA|NA|NA T response regulator, receiver PFHLONEA_00267 335543.Sfum_2258 1.2e-132 479.6 Syntrophobacterales ko:K13525 ko04141,ko05134,map04141,map05134 M00400,M00403 ko00000,ko00001,ko00002,ko03019,ko04131,ko04147 3.A.16.1 Bacteria 1QFHD@1224,2MQYB@213462,2WIT4@28221,42QEP@68525,COG0464@1,COG0464@2 NA|NA|NA O ATPase family associated with various cellular activities (AAA) PFHLONEA_00268 246194.CHY_1281 8.8e-76 290.4 Thermoanaerobacterales 4.99.1.12 ko:K06864,ko:K09121 ko00000,ko01000 Bacteria 1TPB2@1239,2485J@186801,42FCT@68295,COG1606@1,COG1606@2 NA|NA|NA S PFAM PP-loop domain protein PFHLONEA_00271 484770.UFO1_0279 2.4e-92 345.5 Negativicutes gltD 1.18.1.2,1.19.1.1,1.4.1.13,1.4.1.14 ko:K00266,ko:K00528,ko:K02823,ko:K16951 ko00240,ko00250,ko00910,ko00920,ko01100,ko01110,ko01120,ko01130,ko01230,map00240,map00250,map00910,map00920,map01100,map01110,map01120,map01130,map01230 R00093,R00114,R00248,R00858,R10146,R10159 RC00006,RC00010,RC00065,RC02799 ko00000,ko00001,ko01000 Bacteria 1TP6D@1239,4H2FP@909932,COG0543@1,COG0543@2 NA|NA|NA C PFAM oxidoreductase FAD NAD(P)-binding domain protein PFHLONEA_00272 398767.Glov_0704 0.0 1303.1 Deltaproteobacteria uvrA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1905347,GO:1905348,GO:1990391 ko:K03701 ko03420,map03420 ko00000,ko00001,ko03400 Bacteria 1MW0W@1224,2WJHM@28221,42M4I@68525,COG0178@1,COG0178@2 NA|NA|NA L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate PFHLONEA_00274 1123376.AUIU01000011_gene1120 3e-160 572.0 Nitrospirae nadB GO:0000166,GO:0001716,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008734,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0015922,GO:0016491,GO:0016638,GO:0016641,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044318,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605 1.3.5.1,1.3.5.4,1.4.3.16 ko:K00239,ko:K00244,ko:K00278 ko00020,ko00190,ko00250,ko00620,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00250,map00620,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map02020,map05134 M00009,M00011,M00115,M00149,M00150,M00173,M00374,M00376 R00357,R00481,R02164 RC00006,RC00045,RC02566 ko00000,ko00001,ko00002,ko01000 iAF1260.b2574,iBWG_1329.BWG_2338,iECDH10B_1368.ECDH10B_2742,iECDH1ME8569_1439.ECDH1ME8569_2501,iETEC_1333.ETEC_2787,iEcDH1_1363.EcDH1_1094,iJN678.nadB,iJO1366.b2574,iJR904.b2574,iLF82_1304.LF82_1433,iNRG857_1313.NRG857_12785,iSbBS512_1146.nadB,iY75_1357.Y75_RS13445,iYL1228.KPN_02899 Bacteria 3J0DI@40117,COG0029@1,COG0029@2 NA|NA|NA H FAD binding domain PFHLONEA_00275 909663.KI867150_gene2081 8.4e-12 76.3 Syntrophobacterales slp GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0016020,GO:0019867,GO:0042802 ko:K07285 ko00000 Bacteria 1MZ8C@1224,2MSI1@213462,2WQIC@28221,42TQE@68525,COG3065@1,COG3065@2 NA|NA|NA M Outer membrane lipoprotein Slp family PFHLONEA_00277 330214.NIDE0371 2e-78 299.3 Nitrospirae atpG GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 iLJ478.TM1611,iSSON_1240.SSON_3886,iYL1228.KPN_04138 Bacteria 3J0J8@40117,COG0224@1,COG0224@2 NA|NA|NA C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex PFHLONEA_00278 639282.DEFDS_1888 8.1e-213 746.5 Deferribacteres atpA GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016469,GO:0030312,GO:0032991,GO:0040007,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045259,GO:0045260,GO:0071944,GO:0098796,GO:0098797 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 iSB619.SA_RS10975 Bacteria 2GER4@200930,COG0056@1,COG0056@2 NA|NA|NA C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit PFHLONEA_00279 671143.DAMO_2961 4.7e-22 111.3 unclassified Bacteria atpH ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 Bacteria 2NPV0@2323,COG0712@1,COG0712@2 NA|NA|NA C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation PFHLONEA_00280 1232410.KI421422_gene2045 7.4e-18 97.4 Desulfuromonadales atpF GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 ko:K02109,ko:K18682 ko00190,ko00195,ko01100,ko03018,map00190,map00195,map01100,map03018 M00157 ko00000,ko00001,ko00002,ko00194,ko01000,ko03019 3.A.2.1 Bacteria 1N97K@1224,2WR6T@28221,42VYP@68525,43SQ9@69541,COG0711@1,COG0711@2 NA|NA|NA C ATP synthase B/B' CF(0) PFHLONEA_00281 573370.DMR_04760 3.8e-11 74.7 Desulfovibrionales atpF ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 Bacteria 1NA9K@1224,2MCRQ@213115,2WR8C@28221,42VN2@68525,COG0711@1,COG0711@2 NA|NA|NA C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) PFHLONEA_00282 243231.GSU1581 8e-229 800.4 Desulfuromonadales cca 2.7.7.19,2.7.7.72,3.1.13.3,3.1.3.7 ko:K00970,ko:K00974,ko:K06881 ko00920,ko01100,ko01120,ko03013,ko03018,map00920,map01100,map01120,map03013,map03018 R00188,R00508,R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016,ko03019,ko03400 Bacteria 1MU2X@1224,2WJBN@28221,42MJJ@68525,43U0J@69541,COG0617@1,COG0617@2,COG0618@1,COG0618@2,COG3620@1,COG3620@2 NA|NA|NA J CBS domain containing protein PFHLONEA_00286 880072.Desac_2016 8.3e-46 189.9 Syntrophobacterales Bacteria 1RDCG@1224,2MRPV@213462,2WNC2@28221,42RTD@68525,COG4747@1,COG4747@2 NA|NA|NA S ACT domain PFHLONEA_00287 1123376.AUIU01000002_gene1667 2.2e-79 303.1 Bacteria Bacteria 28KQH@1,2ZA8A@2 NA|NA|NA S Alginate export PFHLONEA_00288 1009370.ALO_00845 1.9e-164 585.5 Negativicutes glgC GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008878,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0070566,GO:0071704,GO:1901576 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2768 Bacteria 1TNZW@1239,4H2F7@909932,COG0448@1,COG0448@2 NA|NA|NA H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans PFHLONEA_00289 1121405.dsmv_0657 2.6e-83 316.2 Desulfobacterales fdx7 Bacteria 1MX9D@1224,2MHZX@213118,2WJZD@28221,42PW1@68525,COG3894@1,COG3894@2 NA|NA|NA C Domain of unknown function (DUF4445) PFHLONEA_00290 338963.Pcar_1805 9.5e-184 650.2 Desulfuromonadales glmS GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 iAF987.Gmet_1487 Bacteria 1MW4K@1224,2WJP6@28221,42KZ7@68525,43S1W@69541,COG0449@1,COG0449@2 NA|NA|NA M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source PFHLONEA_00291 269799.Gmet_2033 6.1e-21 107.1 Desulfuromonadales Bacteria 1P6RV@1224,28VTW@1,2WY8G@28221,2ZHVJ@2,433CX@68525,43VUK@69541 NA|NA|NA PFHLONEA_00292 243231.GSU1982 2.2e-96 359.0 Desulfuromonadales Bacteria 1MU3G@1224,2WJ9P@28221,42NNX@68525,43TQ5@69541,COG3267@1,COG3267@2 NA|NA|NA U AAA domain PFHLONEA_00293 289376.THEYE_A0465 1e-42 179.9 Nitrospirae nusG GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 ko:K02601,ko:K05785 ko00000,ko03000,ko03009,ko03021 Bacteria 3J17S@40117,COG0250@1,COG0250@2 NA|NA|NA K Transcription termination factor nusG PFHLONEA_00294 1123368.AUIS01000017_gene2575 4e-25 120.2 Acidithiobacillales lepA GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0006950,GO:0006970,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009268,GO:0009409,GO:0009628,GO:0009651,GO:0009987,GO:0010467,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0042802,GO:0043021,GO:0043023,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0050896,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K03596 ko05134,map05134 ko00000,ko00001 Bacteria 1MVZA@1224,1RPFB@1236,2NBQZ@225057,COG0481@1,COG0481@2 NA|NA|NA J Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner PFHLONEA_00295 243231.GSU1267 1e-53 216.9 Desulfuromonadales lepB 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 ko00000,ko00001,ko01000,ko01002 Bacteria 1MXUF@1224,2WKMA@28221,42NJE@68525,43TTS@69541,COG0681@1,COG0681@2 NA|NA|NA U Signal peptidase, peptidase S26 PFHLONEA_00297 644282.Deba_2078 2.4e-60 239.2 Deltaproteobacteria yicC GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009022,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:0140101,GO:1901360,GO:1901361,GO:1901575 Bacteria 1MWRA@1224,2WJYK@28221,42RFR@68525,COG1561@1,COG1561@2 NA|NA|NA S YicC domain protein PFHLONEA_00298 1499967.BAYZ01000019_gene6316 1.1e-21 109.0 unclassified Bacteria ylzA ko:K09777 ko00000 Bacteria 2NRCM@2323,COG2052@1,COG2052@2 NA|NA|NA S Domain of unknown function (DUF370) PFHLONEA_00299 269799.Gmet_2327 8.6e-57 226.9 Desulfuromonadales gmk GO:0003674,GO:0003824,GO:0004385,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8,4.1.1.23 ko:K00942,ko:K01591 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00050,M00051 R00332,R00965,R02090 RC00002,RC00409 ko00000,ko00001,ko00002,ko01000 iAPECO1_1312.APECO1_2813,iIT341.HP0321,iPC815.YPO0040,iSBO_1134.SBO_3729,iSFV_1184.SFV_3881,iSFxv_1172.SFxv_4016,iUTI89_1310.UTI89_C4193 Bacteria 1MW92@1224,2WNAD@28221,42R4H@68525,43SG2@69541,COG0194@1,COG0194@2 NA|NA|NA F Essential for recycling GMP and indirectly, cGMP PFHLONEA_00300 289376.THEYE_A0403 4.5e-07 61.2 Nitrospirae rpoZ GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944 2.7.7.6 ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 Bacteria 3J0UJ@40117,COG1758@1,COG1758@2 NA|NA|NA K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits PFHLONEA_00301 935948.KE386495_gene1769 1.4e-111 409.8 Thermoanaerobacterales coaBC 4.1.1.36,6.3.2.5 ko:K01598,ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPP3@1239,247J3@186801,42FF1@68295,COG0452@1,COG0452@2 NA|NA|NA H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine PFHLONEA_00302 671143.DAMO_2474 2.7e-13 81.3 unclassified Bacteria ligD 6.5.1.1 ko:K01971 ko03450,map03450 R00381 RC00005 ko00000,ko00001,ko01000,ko03400 Bacteria 2NR3Z@2323,COG1793@1,COG1793@2 NA|NA|NA L DNA polymerase Ligase (LigD) PFHLONEA_00303 269799.Gmet_3376 1.1e-57 229.9 Proteobacteria Bacteria 1RGZW@1224,2A8Q5@1,30XSS@2 NA|NA|NA PFHLONEA_00304 338966.Ppro_2599 8.7e-118 430.3 Desulfuromonadales aroG-1 2.5.1.54 ko:K03856 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 Bacteria 1QVAD@1224,2WJ8Y@28221,42MU4@68525,43TP3@69541,COG2876@1,COG2876@2 NA|NA|NA H NeuB family PFHLONEA_00305 335543.Sfum_2301 2.1e-23 114.4 Deltaproteobacteria dmpI 5.3.2.6 ko:K01821 ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220 M00569 R03966,R05389 RC01040,RC01355 ko00000,ko00001,ko00002,ko01000 Bacteria 1N6WW@1224,2WRUI@28221,42V9V@68525,COG1942@1,COG1942@2 NA|NA|NA S TIGRFAM 4-oxalocrotonate tautomerase family enzyme PFHLONEA_00306 666681.M301_1307 2.8e-47 195.3 Betaproteobacteria yicG GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 1RHQN@1224,2WFPF@28216,COG2860@1,COG2860@2 NA|NA|NA S UPF0126 domain PFHLONEA_00308 118173.KB235914_gene724 2.6e-195 688.3 Oscillatoriales nifK 1.18.6.1 ko:K02591 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 Bacteria 1G2KK@1117,1H85S@1150,COG2710@1,COG2710@2 NA|NA|NA C This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation PFHLONEA_00309 289376.THEYE_A1716 2.3e-204 718.4 Nitrospirae nifD 1.18.6.1 ko:K02586 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0ZE@40117,COG2710@1,COG2710@2 NA|NA|NA C Nitrogenase component 1 type Oxidoreductase PFHLONEA_00310 498761.HM1_0866 1.8e-129 468.8 Clostridia nifH 1.18.6.1 ko:K02588 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPXR@1239,247KJ@186801,COG1348@1,COG1348@2 NA|NA|NA P The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein PFHLONEA_00311 330214.NIDE1582 1.4e-37 162.2 Nitrospirae trxA ko:K03671,ko:K05838 ko04621,ko05418,map04621,map05418 ko00000,ko00001,ko03110 iIT341.HP0824 Bacteria 3J0P6@40117,COG3118@1,COG3118@2 NA|NA|NA O Thioredoxin-like domain PFHLONEA_00313 269799.Gmet_0608 5.2e-116 424.5 Desulfuromonadales argC GO:0003674,GO:0003824,GO:0003942,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 iLJ478.TM1782,iSSON_1240.SSON_4131,iYO844.BSU11190 Bacteria 1MVJ6@1224,2WINX@28221,42MDN@68525,43TEU@69541,COG0002@1,COG0002@2 NA|NA|NA E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde PFHLONEA_00314 338963.Pcar_1899 2e-41 175.3 Desulfuromonadales rpsI GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02996 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1RD4A@1224,2WP7T@28221,42SVI@68525,43SIQ@69541,COG0103@1,COG0103@2 NA|NA|NA J Ribosomal protein S9/S16 PFHLONEA_00315 748449.Halha_0222 1.7e-46 192.2 Halanaerobiales rplM GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0070180,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 ko:K02871 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V3HX@1239,24HD9@186801,3WAPJ@53433,COG0102@1,COG0102@2 NA|NA|NA J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly PFHLONEA_00316 1125863.JAFN01000001_gene360 1.2e-50 207.2 Deltaproteobacteria rpfG Bacteria 1MW7F@1224,2WQU5@28221,42UBK@68525,COG2206@1,COG2206@2 NA|NA|NA T SMART Metal-dependent phosphohydrolase, HD region PFHLONEA_00317 1265505.ATUG01000001_gene3422 3.2e-17 94.7 Desulfobacterales Bacteria 1N3K9@1224,2DMZP@1,2MNTS@213118,2WQ9Z@28221,32UMQ@2,42UFA@68525 NA|NA|NA S Protein of unknown function (DUF3795) PFHLONEA_00318 1348657.M622_15920 4.2e-45 187.2 Rhodocyclales pntB 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 R00112 RC00001 ko00000,ko00001,ko01000 Bacteria 1MUP4@1224,2KURP@206389,2VIDR@28216,COG1282@1,COG1282@2 NA|NA|NA C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane PFHLONEA_00319 289376.THEYE_A1676 7.1e-72 277.3 Nitrospirae ko:K02066 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 3J15A@40117,COG0767@1,COG0767@2 NA|NA|NA Q Permease MlaE PFHLONEA_00320 289376.THEYE_A1677 4.5e-60 238.0 Nitrospirae ttg2A ko:K02065 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 3J12B@40117,COG1127@1,COG1127@2 NA|NA|NA Q ABC transporter PFHLONEA_00321 289376.THEYE_A0330 1.8e-29 136.7 Nitrospirae ttg2C ko:K02067 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 3J164@40117,COG1463@1,COG1463@2 NA|NA|NA Q MlaD protein PFHLONEA_00322 933262.AXAM01000078_gene1614 1.6e-40 172.2 Desulfobacterales yajD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 R06613 RC00022,RC00332 ko00000,ko00001,ko01000 Bacteria 1RGZQ@1224,2MJT7@213118,2WNMG@28221,42REM@68525,COG1403@1,COG1403@2 NA|NA|NA L PFAM HNH endonuclease PFHLONEA_00323 472759.Nhal_2557 1.9e-81 309.3 Gammaproteobacteria 1.17.99.6 ko:K07058,ko:K18979 ko00000,ko01000,ko03016 Bacteria 1NH82@1224,1S3T8@1236,COG1295@1,COG1295@2 NA|NA|NA S ribonuclease BN PFHLONEA_00324 1049564.TevJSym_ax00090 2.5e-211 741.9 unclassified Gammaproteobacteria uup GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010528,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031323,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0070894,GO:0071944,GO:0080090,GO:0097159,GO:1901363 ko:K15738 ko00000,ko02000 3.A.1.120.6 Bacteria 1J4ET@118884,1MU37@1224,1RPCU@1236,COG0488@1,COG0488@2 NA|NA|NA S COG0488 ATPase components of ABC transporters with duplicated ATPase domains PFHLONEA_00325 580332.Slit_0722 1.1e-106 393.3 Nitrosomonadales yvfR ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1MUX3@1224,2VI3G@28216,44VG9@713636,COG1131@1,COG1131@2 NA|NA|NA V PFAM ABC transporter related PFHLONEA_00326 580332.Slit_0721 1.3e-110 406.4 Betaproteobacteria ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1PX28@1224,2VYZC@28216,COG0842@1,COG0842@2 NA|NA|NA V ABC-2 family transporter protein PFHLONEA_00327 1121918.ARWE01000001_gene1325 9.1e-74 283.5 Deltaproteobacteria rsmE 2.1.1.193 ko:K09761 ko00000,ko01000,ko03009 Bacteria 1MZBG@1224,2WN3C@28221,42R3E@68525,COG1385@1,COG1385@2 NA|NA|NA J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit PFHLONEA_00328 1304875.JAFZ01000002_gene336 3.1e-62 245.4 Synergistetes GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016787,GO:0044424,GO:0044444,GO:0044464 ko:K07001 ko00000 Bacteria 3TC9C@508458,COG1752@1,COG1752@2 NA|NA|NA S Patatin-like phospholipase PFHLONEA_00331 56780.SYN_00726 1.8e-32 146.0 Syntrophobacterales Bacteria 1NY54@1224,2MSCI@213462,2WW2X@28221,430VB@68525,COG0589@1,COG0589@2 NA|NA|NA T Universal stress protein family PFHLONEA_00332 1158345.JNLL01000001_gene100 1.6e-64 253.1 Bacteria MA20_41470 ko:K06923 ko00000 Bacteria COG2607@1,COG2607@2 NA|NA|NA E Atpase (Aaa PFHLONEA_00333 1121405.dsmv_2189 4.5e-84 317.8 Desulfobacterales pqqE ko:K22226,ko:K22227 ko00000 Bacteria 1MUQP@1224,2MJ60@213118,2WIKM@28221,42M55@68525,COG0535@1,COG0535@2 NA|NA|NA C PFAM Radical SAM domain protein PFHLONEA_00334 1177154.Y5S_01705 1.7e-44 185.3 Gammaproteobacteria Bacteria 1QW22@1224,1T4AK@1236,COG2885@1,COG2885@2 NA|NA|NA M Ompa motb domain protein PFHLONEA_00335 1232410.KI421425_gene1551 1.6e-51 209.1 Desulfuromonadales Bacteria 1PXEZ@1224,2B4XH@1,2WVH5@28221,32REP@2,4305C@68525,43UUP@69541 NA|NA|NA PFHLONEA_00336 1232410.KI421425_gene1550 5.9e-245 853.6 Desulfuromonadales Bacteria 1MXSS@1224,2WU0G@28221,42Z0Q@68525,43T6R@69541,COG0457@1,COG0457@2 NA|NA|NA S Tetratricopeptide repeat PFHLONEA_00337 1232410.KI421425_gene1549 9.9e-238 829.7 Desulfuromonadales bamD ko:K05807,ko:K08309 ko00000,ko01000,ko01011,ko02000 1.B.33.1 GH23 Bacteria 1QVQ9@1224,2X80K@28221,43CT2@68525,43TUA@69541,COG4105@1,COG4105@2 NA|NA|NA S Tetratricopeptide repeat PFHLONEA_00341 706587.Desti_5051 1.6e-101 375.9 Deltaproteobacteria ko:K07079 ko00000 Bacteria 1QJYC@1224,2WJ6W@28221,42QD6@68525,COG0667@1,COG0667@2 NA|NA|NA C Aldo/keto reductase family PFHLONEA_00342 1267535.KB906767_gene4659 9.8e-105 386.7 Acidobacteriia fpg 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 2JKGK@204432,3Y71J@57723,COG0266@1,COG0266@2 NA|NA|NA L Formamidopyrimidine-DNA glycosylase H2TH domain PFHLONEA_00343 323261.Noc_2717 2.9e-222 777.7 Chromatiales xfp 4.1.2.22,4.1.2.9 ko:K01621 ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120 R00761,R01621 RC00032,RC00226 ko00000,ko00001,ko01000 Bacteria 1MVSE@1224,1RPSW@1236,1WVZE@135613,COG3957@1,COG3957@2 NA|NA|NA G D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase PFHLONEA_00344 391625.PPSIR1_12653 1.7e-20 106.3 Proteobacteria Bacteria 1R4Y3@1224,28KU0@1,2ZAAY@2 NA|NA|NA PFHLONEA_00345 243231.GSU1836 6.1e-44 183.3 Desulfuromonadales glnB ko:K04751,ko:K04752 ko02020,map02020 ko00000,ko00001 Bacteria 1RGWK@1224,2WP4E@28221,42SJJ@68525,43V1G@69541,COG0347@1,COG0347@2 NA|NA|NA K Belongs to the P(II) protein family PFHLONEA_00346 290397.Adeh_0651 5.3e-24 118.6 Myxococcales Bacteria 1R7RK@1224,2WKX6@28221,2YUCP@29,42PPY@68525,COG0457@1,COG0457@2 NA|NA|NA NU Tetratricopeptide repeats PFHLONEA_00347 706587.Desti_4617 1.4e-50 206.5 delta/epsilon subdivisions 2.8.1.13 ko:K00566 ko04122,map04122 R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 Bacteria 1QV6H@1224,43BNM@68525,COG0482@1,COG0482@2 NA|NA|NA J tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain PFHLONEA_00348 1041930.Mtc_1045 4.6e-109 401.4 Archaea Archaea arCOG01186@1,arCOG01186@2157 NA|NA|NA G Mn2 dependent serine threonine protein kinase PFHLONEA_00351 592027.CLG_B0118 2.5e-55 223.0 Clostridiaceae yaaT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 Bacteria 1TP1V@1239,247Q6@186801,36EJN@31979,COG1774@1,COG1774@2 NA|NA|NA S PSP1 domain protein PFHLONEA_00352 1232410.KI421413_gene824 9.4e-61 240.7 Desulfuromonadales holB 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 1QVB3@1224,2WPCK@28221,42SBC@68525,43RXK@69541,COG2812@1,COG2812@2 NA|NA|NA L DNA polymerase III, delta subunit, C terminal PFHLONEA_00353 398767.Glov_1946 1e-55 223.4 Desulfuromonadales tmk GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 1MV9C@1224,2WNES@28221,42RK3@68525,43U3M@69541,COG0125@1,COG0125@2 NA|NA|NA F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis PFHLONEA_00354 1054213.HMPREF9946_00429 5.9e-11 76.3 Rhodospirillales Bacteria 1MVAW@1224,2JVEI@204441,2TTMD@28211,COG4717@1,COG4717@2 NA|NA|NA L AAA domain PFHLONEA_00355 635013.TherJR_2970 1.3e-122 446.8 Peptococcaceae pabB GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004049,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006575,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009108,GO:0009308,GO:0009309,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042398,GO:0042401,GO:0042430,GO:0042435,GO:0042558,GO:0042559,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046820,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 2.6.1.85 ko:K01665 ko00790,map00790 R01716 RC00010,RC01418 ko00000,ko00001,ko01000 Bacteria 1TQAP@1239,24946@186801,26020@186807,COG0147@1,COG0147@2 NA|NA|NA EH Anthranilate synthase component I PFHLONEA_00356 1123248.KB893339_gene2701 3.8e-30 138.3 Bacteria ko:K20276 ko02024,map02024 ko00000,ko00001 Bacteria COG4932@1,COG4932@2,COG5276@1,COG5276@2 NA|NA|NA M domain protein PFHLONEA_00358 1346330.M472_01715 9.6e-33 147.1 Sphingobacteriia Bacteria 1IXXC@117747,29XNE@1,30JDU@2,4NR6R@976 NA|NA|NA PFHLONEA_00359 314254.OA2633_00345 3.8e-13 81.3 Hyphomonadaceae Bacteria 1P8GP@1224,2EAJ0@1,2UWW3@28211,334MZ@2,43ZP3@69657 NA|NA|NA PFHLONEA_00364 1121918.ARWE01000001_gene368 2.9e-09 69.7 delta/epsilon subdivisions yplB ko:K06867 ko00000 Bacteria 1PGQM@1224,433NE@68525,COG0457@1,COG0457@2,COG0666@1,COG0666@2 NA|NA|NA S Tetratricopeptide repeat PFHLONEA_00365 706587.Desti_4742 1e-15 89.4 Deltaproteobacteria Bacteria 1NIYU@1224,2EH48@1,2WSKU@28221,33AW7@2,42XKK@68525 NA|NA|NA PFHLONEA_00366 1163617.SCD_n01099 1.2e-47 196.8 Bacteria yjbF Bacteria COG0398@1,COG0398@2 NA|NA|NA M Pfam SNARE associated Golgi protein PFHLONEA_00367 1125863.JAFN01000001_gene3183 5.9e-70 270.8 Deltaproteobacteria fmt2 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 Bacteria 1MU6N@1224,2WK5J@28221,42P56@68525,COG1611@1,COG1611@2 NA|NA|NA S Belongs to the LOG family PFHLONEA_00368 671143.DAMO_2127 1.4e-48 200.3 Bacteria GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 Bacteria COG0628@1,COG0628@2 NA|NA|NA D permease PFHLONEA_00369 330214.NIDE0536 2.6e-90 339.0 Nitrospirae pdxA 1.1.1.262,1.1.1.408,1.1.1.409 ko:K00097,ko:K22024 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0GF@40117,COG1995@1,COG1995@2 NA|NA|NA C Pyridoxal phosphate biosynthetic protein PdxA PFHLONEA_00370 643648.Slip_0113 6.9e-14 83.2 Syntrophomonadaceae yabO GO:0008150,GO:0040007 Bacteria 1VEI5@1239,24QNF@186801,42KRY@68298,COG1188@1,COG1188@2 NA|NA|NA J S4 RNA-binding domain PFHLONEA_00374 243231.GSU0695 2.4e-61 242.7 Bacteria Bacteria 2911P@1,2ZNP9@2 NA|NA|NA PFHLONEA_00375 1174528.JH992898_gene1079 5.3e-63 247.7 Stigonemataceae yoqW Bacteria 1G1SA@1117,1JHC7@1189,COG2135@1,COG2135@2 NA|NA|NA S SOS response associated peptidase (SRAP) PFHLONEA_00376 944479.JQLX01000010_gene634 1.3e-49 203.0 Desulfurellales 3.4.21.88 ko:K01356,ko:K03503 M00729 ko00000,ko00002,ko01000,ko01002,ko03400 Bacteria 1MW80@1224,2M7KU@213113,2X6X9@28221,42SP5@68525,COG1974@1,COG1974@2 NA|NA|NA K Peptidase S24-like PFHLONEA_00377 56780.SYN_00561 6.3e-137 494.2 Syntrophobacterales umuC GO:0000731,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0003887,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009355,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016021,GO:0016462,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0018130,GO:0019438,GO:0019985,GO:0031224,GO:0031668,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044425,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071496,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02346,ko:K03502 ko00000,ko01000,ko03400 Bacteria 1MUUH@1224,2MQEQ@213462,2WIVT@28221,42NGG@68525,COG0389@1,COG0389@2 NA|NA|NA L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII PFHLONEA_00379 234267.Acid_2495 4.9e-50 204.1 Acidobacteria 3.2.1.45 ko:K01201 ko00511,ko00600,ko01100,ko04142,map00511,map00600,map01100,map04142 R01498 RC00059,RC00451 ko00000,ko00001,ko01000 GH30 Bacteria 3Y3DB@57723,COG3488@1,COG3488@2 NA|NA|NA C Di-haem oxidoreductase, putative peroxidase PFHLONEA_00380 690850.Desaf_2677 3.2e-89 334.7 Bacteria Bacteria COG0500@1,COG2226@2 NA|NA|NA Q methyltransferase PFHLONEA_00381 247490.KSU1_C0538 7.4e-86 323.6 Planctomycetes yhhW ko:K06911 ko00000 Bacteria 2IXVU@203682,COG1741@1,COG1741@2 NA|NA|NA S Belongs to the pirin family PFHLONEA_00382 323848.Nmul_A0712 1.8e-21 109.0 Nitrosomonadales phhB GO:0003674,GO:0003824,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008124,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019438,GO:0019751,GO:0034311,GO:0034312,GO:0034641,GO:0042558,GO:0042559,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 4.2.1.96 ko:K01724 ko00790,map00790 R04734 RC01208 ko00000,ko00001,ko01000,ko04147 Bacteria 1MZ5Q@1224,2VVZF@28216,373A7@32003,COG2154@1,COG2154@2 NA|NA|NA H diol metabolic process PFHLONEA_00383 697282.Mettu_0616 3.5e-94 352.1 Methylococcales 1.7.1.15 ko:K00362 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 Bacteria 1NR3M@1224,1RN6P@1236,1XEW5@135618,COG0446@1,COG0446@2 NA|NA|NA C Apoptosis-inducing factor, mitochondrion-associated, C-term PFHLONEA_00384 795359.TOPB45_0020 1e-43 183.7 Thermodesulfobacteria 2.1.1.223 ko:K15460 ko00000,ko01000,ko03016 Bacteria 2GHE5@200940,COG4123@1,COG4123@2 NA|NA|NA S Methyltransferase small domain PFHLONEA_00385 330214.NIDE4308 7.3e-33 146.7 Nitrospirae ysmA ko:K07107 ko00000,ko01000 Bacteria 3J1EV@40117,COG0824@1,COG0824@2 NA|NA|NA S Thioesterase-like superfamily PFHLONEA_00387 926560.KE387023_gene2058 1.5e-27 129.4 Bacteria Bacteria COG2020@1,COG2020@2 NA|NA|NA O methyltransferase activity PFHLONEA_00391 909663.KI867150_gene1101 2.4e-77 295.0 Deltaproteobacteria Bacteria 1MW0H@1224,2X5AV@28221,42T6P@68525,COG1533@1,COG1533@2 NA|NA|NA L radical SAM domain protein PFHLONEA_00398 247490.KSU1_C0500 4e-60 238.4 Planctomycetes czcD ko:K16264 ko00000,ko02000 2.A.4.1 Bacteria 2J098@203682,COG1230@1,COG1230@2 NA|NA|NA P Cation efflux family PFHLONEA_00399 443143.GM18_2753 3.7e-129 468.0 Deltaproteobacteria JD73_00815 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 Bacteria 1MX2J@1224,2WQAW@28221,42TZR@68525,COG0451@1,COG0451@2 NA|NA|NA M NAD(P)H-binding PFHLONEA_00400 1121396.KB893060_gene2849 2.2e-39 169.5 Desulfobacterales 2.7.13.3 ko:K07709 ko02020,map02020 M00499 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 1NTTH@1224,2MHU3@213118,2WIYS@28221,42MC9@68525,COG3852@1,COG3852@2 NA|NA|NA T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PFHLONEA_00402 589865.DaAHT2_2411 5.5e-105 387.5 Desulfobacterales Bacteria 1MWR0@1224,2MI4U@213118,2WJ1N@28221,42PFW@68525,COG1032@1,COG1032@2 NA|NA|NA C SMART Elongator protein 3 MiaB NifB PFHLONEA_00403 243231.GSU0896 2.4e-101 375.2 Deltaproteobacteria tldD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 ko:K03568 ko00000,ko01002 Bacteria 1MUSK@1224,2WJP8@28221,42QCV@68525,COG0312@1,COG0312@2 NA|NA|NA S Peptidase U62 modulator of DNA gyrase PFHLONEA_00404 1125863.JAFN01000001_gene2998 1.2e-51 209.5 Deltaproteobacteria mog 2.8.1.12 ko:K03635 ko00790,ko01100,ko04122,map00790,map01100,map04122 R09395 RC02507 ko00000,ko00001,ko01000 Bacteria 1R9W2@1224,2WN91@28221,42PGH@68525,COG0521@1,COG0521@2 NA|NA|NA H molybdenum cofactor PFHLONEA_00405 706587.Desti_4616 4.2e-29 135.2 Deltaproteobacteria Bacteria 1N6EP@1224,2WQGR@28221,42U9Y@68525,COG2881@1,COG2881@2 NA|NA|NA M Yip1 domain PFHLONEA_00407 1232410.KI421413_gene715 1.2e-68 266.9 Desulfuromonadales 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1639 Bacteria 1MU94@1224,2WPIV@28221,42RF4@68525,43TWB@69541,COG1940@1,COG1940@2 NA|NA|NA GK PFAM ROK family protein PFHLONEA_00410 330214.NIDE0561 4e-112 411.8 Nitrospirae Bacteria 3J10V@40117,COG0535@1,COG0535@2 NA|NA|NA C Iron-sulfur cluster-binding domain PFHLONEA_00411 237368.SCABRO_00337 6.8e-99 367.5 Planctomycetes ko:K14061 ko00000 Bacteria 2J2C9@203682,COG0589@1,COG0589@2 NA|NA|NA T Proto-chlorophyllide reductase 57 kD subunit PFHLONEA_00412 247490.KSU1_B0265 9.4e-45 187.6 Planctomycetes ko:K00405 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 ko00000,ko00001,ko00002 3.D.4.3 Bacteria 2IZN4@203682,COG2010@1,COG2010@2 NA|NA|NA C Cytochrome C oxidase, cbb3-type, subunit III PFHLONEA_00413 760568.Desku_2034 9.2e-71 274.6 Clostridia ko:K07814 ko00000,ko02022 Bacteria 1UQJH@1239,248UM@186801,COG0745@1,COG0745@2,COG3437@1,COG3437@2 NA|NA|NA T Response regulator containing a CheY-like receiver domain and an HD-GYP domain PFHLONEA_00414 289376.THEYE_A1970 3.2e-99 368.6 Nitrospirae mscS ko:K05802 ko00000,ko02000 1.A.23.1.1 Bacteria 3J0R7@40117,COG3264@1,COG3264@2 NA|NA|NA M Mechanosensitive ion channel PFHLONEA_00415 1232410.KI421424_gene1653 1.2e-85 323.6 Desulfuromonadales yhaM ko:K03698 ko00000,ko01000,ko03019 Bacteria 1NH0C@1224,2WJW2@28221,42Q7X@68525,43T29@69541,COG3481@1,COG3481@2 NA|NA|NA L nucleic acid binding OB-fold tRNA helicase-type PFHLONEA_00416 1121468.AUBR01000030_gene1228 1.1e-97 363.2 Thermoanaerobacterales ftsY ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 Bacteria 1TPRI@1239,247JD@186801,42ENW@68295,COG0552@1,COG0552@2 NA|NA|NA U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) PFHLONEA_00417 986075.CathTA2_2070 6.4e-10 70.1 Bacilli zapA ko:K09888 ko00000,ko03036 Bacteria 1VFZR@1239,4HNRI@91061,COG3027@1,COG3027@2 NA|NA|NA D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division PFHLONEA_00418 1123376.AUIU01000016_gene325 2.4e-133 482.3 Nitrospirae rarA ko:K07452,ko:K07478 ko00000,ko01000,ko02048 Bacteria 3J0H6@40117,COG2256@1,COG2256@2 NA|NA|NA L MgsA AAA+ ATPase C terminal PFHLONEA_00419 289376.THEYE_A1342 1.5e-142 513.1 Nitrospirae rny ko:K18682 ko03018,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 3J0C8@40117,COG1418@1,COG1418@2 NA|NA|NA S Endoribonuclease that initiates mRNA decay PFHLONEA_00420 443144.GM21_3292 6.4e-89 334.0 Desulfuromonadales ymdB GO:0003674,GO:0003824,GO:0004112,GO:0004113,GO:0008081,GO:0016787,GO:0016788,GO:0042578 ko:K02029,ko:K02030,ko:K09769 M00236 ko00000,ko00002,ko02000 3.A.1.3 Bacteria 1MW12@1224,2WM8X@28221,42PCG@68525,43TFA@69541,COG1692@1,COG1692@2 NA|NA|NA S YmdB-like protein PFHLONEA_00421 269799.Gmet_1848 7.3e-108 397.5 Desulfuromonadales xseA 3.1.11.6,3.4.21.102 ko:K03601,ko:K03797 ko03430,map03430 ko00000,ko00001,ko01000,ko01002,ko03400 Bacteria 1MUA4@1224,2WJI6@28221,42MSB@68525,43TW2@69541,COG1570@1,COG1570@2 NA|NA|NA J Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides PFHLONEA_00422 111105.HR09_09380 5.8e-22 110.2 Porphyromonadaceae vorB 1.2.7.11,1.2.7.3,1.2.7.7 ko:K00174,ko:K00186 ko00010,ko00020,ko00280,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197,R07160,R08566,R08567 RC00004,RC02742,RC02833,RC02856 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 22WCE@171551,2FM6R@200643,4NGYK@976,COG0674@1,COG0674@2 NA|NA|NA C Catalyzes the coenzyme A-dependent oxidation of 3-methyl-2-oxobutanoate coupled to the reduction of ferredoxin producing S-(2-methylpropanoyl)-CoA PFHLONEA_00423 796606.BMMGA3_00410 1.3e-104 386.3 Bacillus cysK GO:0000096,GO:0000097,GO:0000098,GO:0003674,GO:0003824,GO:0004122,GO:0004124,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006555,GO:0006563,GO:0006790,GO:0006807,GO:0008134,GO:0008144,GO:0008150,GO:0008152,GO:0008284,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009070,GO:0009087,GO:0009987,GO:0016043,GO:0016053,GO:0016054,GO:0016740,GO:0016765,GO:0016829,GO:0016835,GO:0016836,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0022607,GO:0030170,GO:0032991,GO:0032993,GO:0036094,GO:0042127,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043388,GO:0043436,GO:0043933,GO:0044085,GO:0044093,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046395,GO:0046983,GO:0048037,GO:0048518,GO:0048522,GO:0050662,GO:0050789,GO:0050794,GO:0051098,GO:0051099,GO:0051101,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051291,GO:0065003,GO:0065007,GO:0065009,GO:0070279,GO:0071704,GO:0071840,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1904796,GO:1904798,GO:2000677,GO:2000679 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 Bacteria 1TP30@1239,1ZBC7@1386,4HAMU@91061,COG0031@1,COG0031@2 NA|NA|NA E Belongs to the cysteine synthase cystathionine beta- synthase family PFHLONEA_00426 1536770.R50345_26035 1.6e-109 402.9 Paenibacillaceae 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 Bacteria 1TP21@1239,27271@186822,4HCW2@91061,COG1104@1,COG1104@2 NA|NA|NA E Cys/Met metabolism PLP-dependent enzyme PFHLONEA_00427 338963.Pcar_2345 7.8e-146 523.9 Desulfuromonadales ntrX ko:K02481,ko:K13599 ko02020,map02020 M00498 ko00000,ko00001,ko00002,ko02022 Bacteria 1MU0N@1224,2WJ88@28221,42M03@68525,43TKB@69541,COG2204@1,COG2204@2 NA|NA|NA T response regulator PFHLONEA_00428 2325.TKV_c16560 1.8e-81 309.3 Thermoanaerobacterales nodI ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1TPMQ@1239,248QD@186801,42FQ5@68295,COG1131@1,COG1131@2 NA|NA|NA V pfam abc PFHLONEA_00429 1121430.JMLG01000008_gene1571 4.7e-57 228.0 Peptococcaceae yadH Bacteria 1TSWD@1239,24DHH@186801,261EX@186807,COG0842@1,COG0842@2 NA|NA|NA V PFAM ABC-2 type transporter PFHLONEA_00430 1296416.JACB01000004_gene1133 3.9e-40 171.4 Aquimarina ybcI GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K07038 ko00000 Bacteria 1I2P2@117743,2YIQT@290174,4NPMW@976,COG1988@1,COG1988@2 NA|NA|NA S LexA-binding, inner membrane-associated putative hydrolase PFHLONEA_00431 880073.Calab_2422 1.6e-177 629.8 unclassified Bacteria amyA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.1.25 ko:K22451 ko00500,map00500 R05196 RC00049 ko00000,ko00001,ko01000 GH57 Bacteria 2NQNB@2323,COG1449@1,COG1449@2 NA|NA|NA G Belongs to the glycosyl hydrolase 57 family PFHLONEA_00434 335543.Sfum_3774 4.8e-99 369.4 Syntrophobacterales Bacteria 1NSC1@1224,2MQQM@213462,2X7QS@28221,43CFQ@68525,COG3164@1,COG3164@2 NA|NA|NA S AsmA-like C-terminal region PFHLONEA_00435 398767.Glov_2384 3.8e-18 98.6 Proteobacteria Bacteria 1RK55@1224,2ATWF@1,31JFP@2 NA|NA|NA PFHLONEA_00436 398767.Glov_2384 2.9e-23 115.5 Proteobacteria Bacteria 1RK55@1224,2ATWF@1,31JFP@2 NA|NA|NA PFHLONEA_00437 398767.Glov_2384 1.4e-30 139.8 Proteobacteria Bacteria 1RK55@1224,2ATWF@1,31JFP@2 NA|NA|NA PFHLONEA_00439 56780.SYN_00168 1.6e-131 476.1 Syntrophobacterales dapL 2.6.1.83 ko:K10206 ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230 M00527 R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 1MWS8@1224,2MQAZ@213462,2WKPT@28221,42MEF@68525,COG0436@1,COG0436@2 NA|NA|NA H Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate PFHLONEA_00440 186497.PF0767 5.8e-39 168.7 Thermococci aspB-like1 2.6.1.102,4.1.2.48 ko:K01620,ko:K13010 ko00260,ko00520,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00520,map01100,map01110,map01120,map01130,map01230 R00751,R06171,R10460 RC00006,RC00312,RC00372,RC00781 ko00000,ko00001,ko01000,ko01005,ko01007 Archaea 243U2@183968,2XTRQ@28890,COG0399@1,arCOG00118@2157 NA|NA|NA E Beta-eliminating lyase PFHLONEA_00441 748247.AZKH_0388 7.2e-49 201.4 Bacteria Bacteria COG1032@1,COG1032@2 NA|NA|NA C radical SAM domain protein PFHLONEA_00442 909663.KI867150_gene187 6.1e-20 102.8 Syntrophobacterales cspA ko:K03704 ko00000,ko03000 Bacteria 1N6Q5@1224,2MS84@213462,2WR92@28221,42V0K@68525,COG1278@1,COG1278@2 NA|NA|NA K SMART Cold shock protein PFHLONEA_00443 330214.NIDE4047 1.6e-24 118.6 Bacteria hup ko:K03530 ko00000,ko03032,ko03036,ko03400 Bacteria COG0776@1,COG0776@2 NA|NA|NA L regulation of translation PFHLONEA_00444 909663.KI867150_gene118 7.4e-15 86.7 Syntrophobacterales Bacteria 1NIZI@1224,2MSG5@213462,2WSNX@28221,42WYM@68525,COG0296@1,COG0296@2 NA|NA|NA G PFAM glycoside hydrolase, family 13 domain protein PFHLONEA_00446 671143.DAMO_0054 1.2e-160 573.2 unclassified Bacteria speA GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008923,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564 4.1.1.18,4.1.1.19 ko:K01582,ko:K01585 ko00310,ko00330,ko00960,ko01100,ko01110,map00310,map00330,map00960,map01100,map01110 M00133 R00462,R00566 RC00299 ko00000,ko00001,ko00002,ko01000 Bacteria 2NNUZ@2323,COG1982@1,COG1982@2 NA|NA|NA E Orn/Lys/Arg decarboxylase, C-terminal domain PFHLONEA_00447 671143.DAMO_0053 2.8e-115 421.8 unclassified Bacteria speE GO:0003674,GO:0003824,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0010487,GO:0016740,GO:0016765,GO:0034641,GO:0042401,GO:0043919,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0071704,GO:1901564,GO:1901566,GO:1901576 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 Bacteria 2NPMY@2323,COG0421@1,COG0421@2 NA|NA|NA E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine PFHLONEA_00448 1123376.AUIU01000013_gene1779 4e-43 181.0 Nitrospirae speH 4.1.1.50 ko:K01611 ko00270,ko00330,ko01100,map00270,map00330,map01100 M00034,M00133 R00178 RC00299 ko00000,ko00001,ko00002,ko01000 Bacteria 3J15H@40117,COG1586@1,COG1586@2 NA|NA|NA F Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine PFHLONEA_00450 755732.Fluta_1674 2.8e-08 65.9 Cryomorphaceae Bacteria 1HXTT@117743,2PATM@246874,4NEPX@976,COG0727@1,COG0727@2 NA|NA|NA S Protein of unknown function (DUF3109) PFHLONEA_00452 1230338.MOMA_06461 5.7e-24 117.5 Moraxellaceae spr GO:0000270,GO:0003674,GO:0003824,GO:0004175,GO:0006022,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009254,GO:0016787,GO:0019538,GO:0030203,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901135,GO:1901564 3.4.17.13 ko:K13694,ko:K13695 ko00000,ko01000,ko01002,ko01011 Bacteria 1N0EE@1224,1RP3P@1236,3NRGK@468,COG0791@1,COG0791@2 NA|NA|NA M NlpC/P60 family PFHLONEA_00453 289376.THEYE_A1244 2.3e-82 312.4 Bacteria Bacteria COG3431@1,COG3431@2 NA|NA|NA PFHLONEA_00454 439235.Dalk_3566 4e-30 138.3 Desulfobacterales ko:K07168 ko00000 Bacteria 1Q1A8@1224,2MKBJ@213118,2WPF0@28221,42SIQ@68525,COG3448@1,COG3448@2 NA|NA|NA T PFAM CBS domain PFHLONEA_00455 525897.Dbac_1921 3.2e-58 231.5 Desulfovibrionales ko:K04767,ko:K07168 ko00000 Bacteria 1MXJG@1224,2MBBZ@213115,2WNED@28221,42RSQ@68525,COG3448@1,COG3448@2 NA|NA|NA T HPP family PFHLONEA_00460 56780.SYN_00378 2.6e-27 128.6 Deltaproteobacteria ko:K09931 ko00000 Bacteria 1RB1V@1224,2WQPQ@28221,42U9T@68525,COG3222@1,COG3222@2 NA|NA|NA S protein conserved in bacteria (DUF2064) PFHLONEA_00461 247490.KSU1_D0419 1.7e-60 239.6 Planctomycetes Bacteria 2J0DV@203682,COG3000@1,COG3000@2 NA|NA|NA I Fatty acid hydroxylase superfamily PFHLONEA_00463 1123376.AUIU01000007_gene1193 8.1e-66 256.9 Nitrospirae nth 4.2.99.18 ko:K10773 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 3J0K6@40117,COG0177@1,COG0177@2 NA|NA|NA L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate PFHLONEA_00464 697282.Mettu_3902 1.8e-90 339.7 Methylococcales 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 R00578 RC00010 ko00000,ko00001,ko01000,ko01002 Bacteria 1QTH7@1224,1RXHP@1236,1XFTD@135618,COG0438@1,COG0438@2 NA|NA|NA M Glycosyltransferase Family 4 PFHLONEA_00465 1189612.A33Q_2493 1.7e-35 156.8 Cytophagia Bacteria 47S3S@768503,4NMHX@976,COG0438@1,COG0438@2 NA|NA|NA M Glycosyl transferases group 1 PFHLONEA_00467 580332.Slit_1785 9.9e-110 403.7 Betaproteobacteria ttuD 2.7.1.165 ko:K11529 ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200 M00346 R08572 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 Bacteria 1MVIK@1224,2VHXK@28216,COG2379@1,COG2379@2 NA|NA|NA G hydroxypyruvate reductase PFHLONEA_00468 909663.KI867151_gene3008 1.8e-157 562.4 Syntrophobacterales 2.4.1.268 ko:K21349 ko00000,ko01000 GT81 Bacteria 1R547@1224,2MR35@213462,2WKYW@28221,42PDC@68525,COG0463@1,COG0463@2 NA|NA|NA M glycosyl transferase family 2 PFHLONEA_00469 909663.KI867151_gene3009 3e-29 135.6 Syntrophobacterales ygxB Bacteria 1RK3V@1224,2MSF0@213462,2X9SI@28221,437YT@68525,COG0668@1,COG0668@2 NA|NA|NA M transmembrane transport PFHLONEA_00470 292459.STH1388 7.2e-26 124.4 Clostridia yeeE GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K07112 ko00000 Bacteria 1TSNG@1239,25DZC@186801,COG2391@1,COG2391@2 NA|NA|NA S Sulphur transport PFHLONEA_00472 443143.GM18_2065 6.3e-21 107.1 Deltaproteobacteria ko:K07006 ko00000 Bacteria 1N11C@1224,2WSBQ@28221,42W6R@68525,COG3576@1,COG3576@2 NA|NA|NA S Pfam:Pyridox_oxidase PFHLONEA_00473 1122221.JHVI01000017_gene2093 1.9e-37 162.2 Deinococcus-Thermus Bacteria 1WJV4@1297,COG2905@1,COG2905@2 NA|NA|NA T signal-transduction protein containing cAMP-binding and CBS domains PFHLONEA_00474 671143.DAMO_1396 8.4e-93 347.4 unclassified Bacteria livM GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039 ko:K01995,ko:K01998 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 iPC815.YPO3806,iSDY_1059.SDY_3605 Bacteria 2NNYG@2323,COG0411@1,COG0411@2,COG4177@1,COG4177@2 NA|NA|NA E Branched-chain amino acid ATP-binding cassette transporter PFHLONEA_00475 671143.DAMO_1396 5e-78 297.7 unclassified Bacteria livM GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039 ko:K01995,ko:K01998 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 iPC815.YPO3806,iSDY_1059.SDY_3605 Bacteria 2NNYG@2323,COG0411@1,COG0411@2,COG4177@1,COG4177@2 NA|NA|NA E Branched-chain amino acid ATP-binding cassette transporter PFHLONEA_00480 330214.NIDE4134 4.9e-116 424.9 Nitrospirae nusA GO:0001000,GO:0001121,GO:0001125,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 ko:K02600 ko00000,ko03009,ko03021 Bacteria 3J0DF@40117,COG0195@1,COG0195@2 NA|NA|NA K Participates in both transcription termination and antitermination PFHLONEA_00481 1317118.ATO8_13617 2.6e-14 85.5 Roseivivax ylxR ko:K02600,ko:K07742 ko00000,ko03009,ko03021 Bacteria 1RHPR@1224,2U9RY@28211,4KK9C@93682,COG2740@1,COG2740@2 NA|NA|NA J Protein of unknown function (DUF448) PFHLONEA_00484 335543.Sfum_0644 1.9e-50 205.3 Syntrophobacterales ko:K07090 ko00000 Bacteria 1MWX2@1224,2MQWI@213462,2WIP0@28221,42MRE@68525,COG0730@1,COG0730@2 NA|NA|NA S membrane transporter protein PFHLONEA_00485 335543.Sfum_0645 5e-72 277.7 Syntrophobacterales Bacteria 1RE16@1224,2C5J8@1,2MRTU@213462,2WNIF@28221,30F9Z@2,42RYB@68525 NA|NA|NA PFHLONEA_00486 880073.Calab_3405 6.9e-56 225.3 unclassified Bacteria Bacteria 2NPGF@2323,COG4191@1,COG4191@2 NA|NA|NA T His Kinase A (phosphoacceptor) domain PFHLONEA_00487 179408.Osc7112_0917 4.7e-37 161.0 Oscillatoriales Bacteria 1G0SY@1117,1H7V4@1150,COG3290@1,COG3290@2,COG3829@1,COG3829@2,COG5001@1,COG5001@2 NA|NA|NA T signal transduction protein containing a membrane domain an EAL and a GGDEF domain PFHLONEA_00488 1313265.JNIE01000002_gene814 0.0 1751.5 Aquificae gltB GO:0003674,GO:0003824,GO:0004355,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045181,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 iBWG_1329.BWG_2914,iECDH10B_1368.ECDH10B_3387,iECDH1ME8569_1439.EcDH1_0495,iEcDH1_1363.EcDH1_0495,iPC815.YPO3557 Bacteria 2G3VB@200783,COG0067@1,COG0067@2,COG0069@1,COG0069@2,COG0070@1,COG0070@2 NA|NA|NA E glutamate synthase alpha subunit domain protein PFHLONEA_00489 589865.DaAHT2_0147 7.7e-70 270.8 Deltaproteobacteria trxB2 1.8.1.9 ko:K00384 ko00450,map00450 R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 Bacteria 1MVWS@1224,2WPYC@28221,42YY5@68525,COG0492@1,COG0492@2 NA|NA|NA C Pyridine nucleotide-disulphide oxidoreductase PFHLONEA_00490 1121406.JAEX01000001_gene530 1.9e-48 199.1 Desulfovibrionales yigB GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0017144,GO:0018130,GO:0022611,GO:0032502,GO:0034641,GO:0042364,GO:0042578,GO:0042726,GO:0042727,GO:0043167,GO:0043169,GO:0043726,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 3.1.3.10,3.1.3.102,3.1.3.104 ko:K07025,ko:K18569,ko:K20860,ko:K20862,ko:K20866 ko00010,ko00332,ko00740,ko01100,ko01110,ko01120,ko01130,map00010,map00332,map00740,map01100,map01110,map01120,map01130 M00125 R00548,R00947,R07280,R10748 RC00017,RC00078 ko00000,ko00001,ko00002,ko01000 Bacteria 1RJI6@1224,2MC02@213115,2WP75@28221,42STD@68525,COG1011@1,COG1011@2 NA|NA|NA S TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 PFHLONEA_00491 1216932.CM240_2035 4.8e-08 63.9 Clostridiaceae spoIIAA ko:K04749,ko:K06378 ko00000,ko03021 Bacteria 1VENG@1239,24R0X@186801,36KNM@31979,COG1366@1,COG1366@2 NA|NA|NA T Belongs to the anti-sigma-factor antagonist family PFHLONEA_00492 671143.DAMO_0812 9.5e-54 217.2 unclassified Bacteria pcrA GO:0000018,GO:0000166,GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030312,GO:0030554,GO:0031323,GO:0031324,GO:0032392,GO:0032508,GO:0032552,GO:0032554,GO:0032558,GO:0032564,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0036094,GO:0040007,GO:0042623,GO:0043138,GO:0043140,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0045910,GO:0045934,GO:0046483,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 ko:K03656,ko:K03657 ko03420,ko03430,map03420,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 2NNZG@2323,COG0210@1,COG0210@2 NA|NA|NA L UvrD/REP helicase N-terminal domain PFHLONEA_00493 586413.CCDL010000004_gene3504 1.1e-22 112.5 Oceanobacillus gatC 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 Bacteria 1VEK3@1239,23KPF@182709,4HNNA@91061,COG0721@1,COG0721@2 NA|NA|NA J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) PFHLONEA_00494 330214.NIDE2919 2.6e-37 161.4 Nitrospirae panD 4.1.1.11 ko:K01579 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R00489 RC00299 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0Q2@40117,COG0853@1,COG0853@2 NA|NA|NA H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine PFHLONEA_00496 349521.HCH_06486 6e-46 190.7 Oceanospirillales Bacteria 1MWN0@1224,1RQA6@1236,1XKJV@135619,COG0789@1,COG0789@2 NA|NA|NA K transcriptional regulator PFHLONEA_00497 1246995.AFR_10950 6.3e-32 144.4 Micromonosporales Bacteria 2IMEB@201174,4DFTR@85008,COG1309@1,COG1309@2 NA|NA|NA K Bacterial regulatory proteins, tetR family PFHLONEA_00498 1196322.A370_03741 1.2e-12 79.3 Clostridiaceae Bacteria 1UHW0@1239,24FZ0@186801,36JW5@31979,COG0655@1,COG0655@2 NA|NA|NA S PFAM NADPH-dependent FMN reductase PFHLONEA_00500 1123277.KB893172_gene963 1.2e-62 246.5 Cytophagia ko:K02003 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 47KDU@768503,4NE5N@976,COG1136@1,COG1136@2 NA|NA|NA V ABC transporter PFHLONEA_00506 443143.GM18_3467 5.7e-36 159.1 Bacteria Bacteria 2FD1K@1,34543@2 NA|NA|NA PFHLONEA_00507 1123376.AUIU01000014_gene712 1.3e-40 172.9 Bacteria pfpI3 2.7.11.1,3.5.1.124 ko:K03152,ko:K05520,ko:K12132 ko00000,ko01000,ko01001,ko01002 Bacteria COG0693@1,COG0693@2 NA|NA|NA S protein deglycation PFHLONEA_00508 234267.Acid_1106 3.5e-42 178.3 Acidobacteria Bacteria 3Y7W0@57723,COG0586@1,COG0586@2 NA|NA|NA S SNARE associated Golgi protein PFHLONEA_00509 861299.J421_0175 5e-15 87.4 Gemmatimonadetes atoC ko:K07713,ko:K07714,ko:K10943 ko02020,ko05111,map02020,map05111 M00499,M00500,M00515 ko00000,ko00001,ko00002,ko02022 Bacteria 1ZTDN@142182,COG2204@1,COG2204@2 NA|NA|NA T Bacterial regulatory protein, Fis family PFHLONEA_00510 935948.KE386494_gene928 3.4e-157 561.6 Thermoanaerobacterales ko:K07137 ko00000 Bacteria 1TP9I@1239,247QM@186801,42FH5@68295,COG2509@1,COG2509@2 NA|NA|NA S PFAM FAD dependent oxidoreductase PFHLONEA_00511 1121405.dsmv_0412 1.9e-109 402.5 Desulfobacterales cydB 1.10.3.14 ko:K00426 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 iAPECO1_1312.cydB,iJN678.cydB Bacteria 1MURP@1224,2MJNW@213118,2WN5S@28221,42QTB@68525,COG1294@1,COG1294@2 NA|NA|NA C Cytochrome bd terminal oxidase subunit II PFHLONEA_00512 1121405.dsmv_0411 3.3e-160 571.6 Desulfobacterales cydA 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 iJN678.cydA Bacteria 1MV60@1224,2MIYI@213118,2WJJQ@28221,42P0J@68525,COG1271@1,COG1271@2 NA|NA|NA C Cytochrome bd terminal oxidase subunit I PFHLONEA_00513 269799.Gmet_1814 3.1e-51 208.0 Deltaproteobacteria actE Bacteria 1RHGQ@1224,2WSJM@28221,42XMG@68525,COG2010@1,COG2010@2 NA|NA|NA C cytochrome C PFHLONEA_00514 269799.Gmet_1813 2.8e-53 214.9 Bacteria Bacteria 2DSXF@1,33HTI@2 NA|NA|NA S Protein of unknown function (DUF3341) PFHLONEA_00515 269799.Gmet_1812 5.5e-29 133.3 Desulfuromonadales nrfD ko:K00185 ko00000 5.A.3 Bacteria 1PFX4@1224,2WM3C@28221,42PIE@68525,43SBI@69541,COG5557@1,COG5557@2 NA|NA|NA C Polysulphide reductase, NrfD PFHLONEA_00516 1040989.AWZU01000011_gene4076 2.1e-99 369.4 Bradyrhizobiaceae ko:K20276 ko02024,map02024 ko00000,ko00001 Bacteria 1R95Z@1224,2UFTG@28211,3K2JC@41294,COG1520@1,COG1520@2 NA|NA|NA S Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane PFHLONEA_00518 269799.Gmet_1563 1.6e-116 426.0 Proteobacteria Bacteria 1REVI@1224,2905E@1,2ZMVA@2 NA|NA|NA PFHLONEA_00519 932678.THERU_01595 1.3e-11 76.3 Aquificae Bacteria 2E20Q@1,2G53C@200783,32X8P@2 NA|NA|NA PFHLONEA_00521 990285.RGCCGE502_16355 1.9e-32 146.0 Rhizobiaceae Bacteria 1PPXD@1224,2V2C6@28211,4BI58@82115,COG2370@1,COG2370@2 NA|NA|NA O HupE / UreJ protein PFHLONEA_00522 395492.Rleg2_5110 3e-57 228.4 Rhizobiaceae ureJ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03192 ko00000 Bacteria 1N08F@1224,2UA0Y@28211,4B7VB@82115,COG2370@1,COG2370@2 NA|NA|NA O HupE / UreJ protein PFHLONEA_00523 1121878.AUGL01000021_gene2817 5.8e-90 337.8 Gammaproteobacteria Bacteria 1MV6Z@1224,1RRHA@1236,COG2370@1,COG2370@2 NA|NA|NA O HupE / UreJ protein PFHLONEA_00524 1217718.ALOU01000007_gene1258 9.4e-60 237.3 Betaproteobacteria 5.2.1.8 ko:K03771 ko00000,ko01000,ko03110 Bacteria 1R4ZR@1224,2W0N2@28216,COG0760@1,COG0760@2 NA|NA|NA O PPIC-type PPIASE domain PFHLONEA_00525 289376.THEYE_A1353 3.8e-08 63.5 Bacteria secE GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K03073 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 Bacteria COG0690@1,COG0690@2 NA|NA|NA U P-P-bond-hydrolysis-driven protein transmembrane transporter activity PFHLONEA_00526 644282.Deba_2950 2.9e-56 224.9 Deltaproteobacteria nusG GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0030312,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 ko:K02601 ko00000,ko03009,ko03021 Bacteria 1MU14@1224,2WMP6@28221,42MPQ@68525,COG0250@1,COG0250@2 NA|NA|NA K Participates in transcription elongation, termination and antitermination PFHLONEA_00527 330214.NIDE1300 1.5e-55 222.2 Nitrospirae rplK GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010467,GO:0015934,GO:0015968,GO:0016043,GO:0019538,GO:0019843,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0032984,GO:0032991,GO:0033554,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0042594,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0051716,GO:0065003,GO:0070925,GO:0071496,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02867 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0K2@40117,COG0080@1,COG0080@2 NA|NA|NA J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors PFHLONEA_00528 1304880.JAGB01000003_gene1221 5.4e-87 327.4 Clostridia rplA GO:0000027,GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006417,GO:0006446,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0017148,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045947,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 ko:K02863 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1TPTS@1239,247JB@186801,COG0081@1,COG0081@2 NA|NA|NA J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release PFHLONEA_00529 1144275.COCOR_04968 3.9e-34 151.4 Deltaproteobacteria rplJ GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0017148,GO:0019222,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 ko:K02864,ko:K02935 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1RAN5@1224,2WQE8@28221,42R1J@68525,COG0244@1,COG0244@2 NA|NA|NA J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors PFHLONEA_00530 1110502.TMO_2641 6.6e-39 166.8 Rhodospirillales rplL ko:K02935 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1RGU4@1224,2JSU1@204441,2U9FX@28211,COG0222@1,COG0222@2 NA|NA|NA J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation PFHLONEA_00531 330214.NIDE1303 0.0 1772.3 Nitrospirae rpoB GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03043,ko:K13797 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 Bacteria 3J0CW@40117,COG0085@1,COG0085@2 NA|NA|NA K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates PFHLONEA_00534 237368.SCABRO_00865 2.4e-15 88.6 Planctomycetes Bacteria 2J4E4@203682,COG1895@1,COG1895@2 NA|NA|NA S HEPN domain PFHLONEA_00535 1305737.JAFX01000001_gene2224 4.8e-23 114.0 Cytophagia Bacteria 47R93@768503,4NQCK@976,COG4731@1,COG4731@2 NA|NA|NA S Uncharacterized protein conserved in bacteria (DUF2147) PFHLONEA_00536 926561.KB900623_gene1092 1.1e-62 246.9 Halanaerobiales nfo GO:0000726,GO:0003674,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0008833,GO:0009987,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.21.2 ko:K01151 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 1TP1D@1239,2499E@186801,3WABN@53433,COG0648@1,COG0648@2 NA|NA|NA L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin PFHLONEA_00537 1123376.AUIU01000015_gene423 1.9e-249 868.6 Nitrospirae ligA GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 Bacteria 3J0W8@40117,COG0272@1,COG0272@2 NA|NA|NA L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA PFHLONEA_00539 1379698.RBG1_1C00001G1265 2.9e-132 478.8 unclassified Bacteria Bacteria 2NNWS@2323,COG2204@1,COG2204@2 NA|NA|NA T Two component, sigma54 specific, transcriptional regulator, Fis family PFHLONEA_00540 243231.GSU1494 4.3e-18 97.1 Desulfuromonadales pilS 2.7.13.3 ko:K02668 ko02020,map02020 M00501 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 Bacteria 1QVAT@1224,2X717@28221,43BPZ@68525,43TK3@69541,COG5000@1,COG5000@2 NA|NA|NA T Sensor histidine kinase PilS, PAS domain-containing PFHLONEA_00541 290512.Paes_1621 1.1e-114 420.2 Chlorobi ackA 2.7.2.1 ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 Bacteria 1FDWK@1090,COG0282@1,COG0282@2 NA|NA|NA F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction PFHLONEA_00542 56780.SYN_03004 5.1e-13 81.3 Syntrophobacterales ko:K03646 ko00000,ko02000 2.C.1.2 Bacteria 1R7D3@1224,2MRQW@213462,2X6IP@28221,42Y44@68525,COG3064@1,COG3064@2 NA|NA|NA M Membrane PFHLONEA_00543 523791.Kkor_1762 1.1e-33 150.2 Gammaproteobacteria Bacteria 1RFZS@1224,1S1NP@1236,COG4262@1,COG4262@2 NA|NA|NA S Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine PFHLONEA_00544 1278073.MYSTI_06053 4.2e-39 168.7 Myxococcales speE 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 Bacteria 1N1PJ@1224,2X7I7@28221,2Z1WH@29,43C7V@68525,COG0421@1,COG0421@2 NA|NA|NA H Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine PFHLONEA_00545 388413.ALPR1_13335 9.4e-94 350.5 Bacteria 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 Bacteria COG1233@1,COG1233@2 NA|NA|NA Q all-trans-retinol 13,14-reductase activity PFHLONEA_00547 941449.dsx2_2139 2.5e-09 68.6 Desulfovibrionales Bacteria 1N3P4@1224,2E20Q@1,2MCZ9@213115,2WQ7Q@28221,32X8P@2,42TSV@68525 NA|NA|NA PFHLONEA_00548 909663.KI867149_gene3372 2.4e-45 188.7 Syntrophobacterales Bacteria 1RAIB@1224,2MQJ7@213462,2WN8Y@28221,42S9D@68525,COG2930@1,COG2930@2 NA|NA|NA S Las17-binding protein actin regulator PFHLONEA_00549 443143.GM18_0122 9.5e-15 85.5 Bacteria Bacteria 2EIK5@1,33CBF@2 NA|NA|NA PFHLONEA_00550 1220534.B655_0362 1.4e-07 62.8 Methanobacteria 1.8.1.8 ko:K04084 ko00000,ko01000,ko03110 5.A.1.1 Archaea 23PW6@183925,2Y7A6@28890,COG0526@1,arCOG01976@2157 NA|NA|NA O Protein of unknown function, DUF255 PFHLONEA_00551 240015.ACP_0849 1.1e-60 240.4 Acidobacteriia Bacteria 2JKJ0@204432,3Y644@57723,COG0702@1,COG0702@2 NA|NA|NA GM NmrA-like family PFHLONEA_00552 1125863.JAFN01000001_gene3029 1.5e-09 68.9 Deltaproteobacteria pilT-1 ko:K02669 ko00000,ko02035,ko02044 3.A.15.2 Bacteria 1MU3J@1224,2WJ28@28221,42M7F@68525,COG2805@1,COG2805@2 NA|NA|NA NU PFAM Type II secretion system protein E PFHLONEA_00553 1050202.KB913024_gene868 7.4e-22 110.5 Actinopolysporales recX GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03565 ko00000,ko03400 Bacteria 2GMRF@201174,409BD@622450,COG2137@1,COG2137@2 NA|NA|NA S RecX family PFHLONEA_00554 269799.Gmet_0201 5.2e-292 1010.4 Desulfuromonadales alaS GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002161,GO:0002196,GO:0003674,GO:0003700,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006355,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009451,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:0140110,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iECABU_c1320.ECABU_c29670,iECED1_1282.ECED1_3146,iEcHS_1320.EcHS_A2833,iJN746.PP_4474 Bacteria 1MU9A@1224,2WJA8@28221,42M70@68525,43THC@69541,COG0013@1,COG0013@2 NA|NA|NA J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain PFHLONEA_00555 1340493.JNIF01000003_gene1789 2.3e-07 63.5 Bacteria Bacteria COG3391@1,COG3391@2 NA|NA|NA CO amine dehydrogenase activity PFHLONEA_00558 316067.Geob_0784 1.4e-17 97.1 Desulfuromonadales ftsQ GO:0000003,GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0019954,GO:0022402,GO:0022414,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032505,GO:0032506,GO:0040007,GO:0042802,GO:0043093,GO:0044085,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047 6.3.2.4 ko:K01921,ko:K03589,ko:K06438 ko00473,ko00550,ko01100,ko01502,ko04112,map00473,map00550,map01100,map01502,map04112 R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011,ko03036 Bacteria 1RDX7@1224,2WRVM@28221,42VCZ@68525,43UHQ@69541,COG1589@1,COG1589@2 NA|NA|NA D Essential cell division protein PFHLONEA_00559 316067.Geob_0783 1.3e-93 349.7 Desulfuromonadales ddl 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 Bacteria 1MUTB@1224,2WJ7Q@28221,42NF2@68525,43U8P@69541,COG1181@1,COG1181@2 NA|NA|NA F Cell wall formation PFHLONEA_00560 562970.Btus_1856 1.3e-64 253.4 Alicyclobacillaceae murB 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 iYO844.BSU15230 Bacteria 1TP3W@1239,2785S@186823,4HAD8@91061,COG0812@1,COG0812@2 NA|NA|NA M Cell wall formation PFHLONEA_00561 338963.Pcar_2201 2.6e-165 588.6 Desulfuromonadales murC GO:0000166,GO:0000270,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034645,GO:0035639,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 iECP_1309.ECP_0093,iJN678.murC Bacteria 1MV68@1224,2WK50@28221,42MMP@68525,43T1G@69541,COG0773@1,COG0773@2 NA|NA|NA M UDP-N-acetylmuramate-L-alanine ligase activity PFHLONEA_00562 1278073.MYSTI_06194 1.8e-73 283.1 Myxococcales murG GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0050511,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 GT28 iLJ478.TM0232,iSFV_1184.SFV_0083,iSF_1195.SF0087,iSFxv_1172.SFxv_0091,iS_1188.S0089 Bacteria 1MVIB@1224,2WJNY@28221,2YWEZ@29,42ME1@68525,COG0707@1,COG0707@2 NA|NA|NA M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) PFHLONEA_00563 269799.Gmet_0411 3.8e-90 338.6 Desulfuromonadales ftsW GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008360,GO:0009987,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032153,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051179,GO:0051234,GO:0051301,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:1901264,GO:1901505 2.4.1.227 ko:K02563,ko:K03588 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011,ko02000,ko03036 2.A.103.1 GT28 Bacteria 1MVDB@1224,2WJ01@28221,42MG2@68525,43TAE@69541,COG0772@1,COG0772@2 NA|NA|NA D Peptidoglycan polymerase that is essential for cell division PFHLONEA_00564 671143.DAMO_2299 2.4e-107 396.0 unclassified Bacteria murD GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008764,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 iAPECO1_1312.APECO1_1898,iECNA114_1301.ECNA114_0081,iECOK1_1307.ECOK1_0089,iECP_1309.ECP_0090,iECS88_1305.ECS88_0091,iECSF_1327.ECSF_0098,iLF82_1304.LF82_1418,iNRG857_1313.NRG857_00450,iUMN146_1321.UM146_23225,iUTI89_1310.UTI89_C0097 Bacteria 2NP27@2323,COG0771@1,COG0771@2 NA|NA|NA M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) PFHLONEA_00565 289376.THEYE_A1326 3.8e-109 401.4 Nitrospirae mraY GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 iAF987.Gmet_0409,iEC042_1314.EC042_0088,iECABU_c1320.ECABU_c00920,iECED1_1282.ECED1_0088,iECH74115_1262.ECH74115_0095,iECSP_1301.ECSP_0090,iECs_1301.ECs0091,iG2583_1286.G2583_0091,iSDY_1059.SDY_0117,iZ_1308.Z0097,ic_1306.c0105 Bacteria 3J0C4@40117,COG0472@1,COG0472@2 NA|NA|NA M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan PFHLONEA_00568 1318628.MARLIPOL_12500 1.4e-29 136.7 Alteromonadaceae ko:K07289 ko00000 Bacteria 1NARH@1224,1SE5J@1236,468PT@72275,COG2982@1,COG2982@2 NA|NA|NA M Protein involved in outer membrane biogenesis PFHLONEA_00569 1232410.KI421421_gene3792 1.2e-67 263.1 Desulfuromonadales yejC Bacteria 1RIDY@1224,2WSAF@28221,42WI7@68525,43VM2@69541,COG4420@1,COG4420@2 NA|NA|NA S Protein of unknown function (DUF1003) PFHLONEA_00570 526227.Mesil_2725 1.2e-07 62.8 Deinococcus-Thermus GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005267,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015267,GO:0015318,GO:0015672,GO:0016043,GO:0022607,GO:0022803,GO:0022838,GO:0022840,GO:0022841,GO:0022842,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0043933,GO:0044085,GO:0046873,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055085,GO:0065003,GO:0071804,GO:0071805,GO:0071840,GO:0098655,GO:0098660,GO:0098662 Bacteria 1WN5V@1297,COG3548@1,COG3548@2 NA|NA|NA S Protein of unknown function (DUF1211) PFHLONEA_00572 1191523.MROS_0568 3.4e-70 271.6 Bacteria Bacteria COG0702@1,COG0702@2 NA|NA|NA GM epimerase PFHLONEA_00573 247490.KSU1_D0030 2.3e-73 282.3 Planctomycetes Bacteria 2J2KE@203682,COG3945@1,COG3945@2 NA|NA|NA S Hemerythrin HHE cation binding domain PFHLONEA_00574 247490.KSU1_D0031 1.4e-51 209.1 Planctomycetes napF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0044424,GO:0044464,GO:0050896 ko:K02572 ko00000 Bacteria 2J2T6@203682,COG1145@1,COG1145@2 NA|NA|NA C 4fe-4S ferredoxin, iron-sulfur binding domain protein PFHLONEA_00575 1382359.JIAL01000001_gene3036 1.1e-16 95.1 Acidobacteriia Bacteria 2JK79@204432,3Y3ZS@57723,COG0308@1,COG0308@2 NA|NA|NA E Phospholipase B PFHLONEA_00576 243233.MCA0119 3.5e-28 131.3 Gammaproteobacteria Bacteria 1N2EC@1224,1SZ10@1236,COG0454@1,COG0456@2 NA|NA|NA K Acetyltransferase (GNAT) domain PFHLONEA_00577 103690.17131605 8.8e-25 119.4 Nostocales fdxB ko:K03616,ko:K08941 M00598 ko00000,ko00002,ko00194 Bacteria 1GQ0I@1117,1HSKB@1161,COG4231@1,COG4231@2 NA|NA|NA C 4Fe-4S dicluster domain PFHLONEA_00578 289376.THEYE_A1711 1.2e-49 202.6 Nitrospirae ko:K02589,ko:K02590,ko:K04751,ko:K04752 ko02020,map02020 ko00000,ko00001 Bacteria 3J17E@40117,COG0347@1,COG0347@2 NA|NA|NA K Nitrogen regulatory protein P-II PFHLONEA_00579 289376.THEYE_A1712 3.1e-35 154.1 Nitrospirae ko:K02589,ko:K02590,ko:K04751,ko:K04752 ko02020,map02020 ko00000,ko00001 Bacteria 3J172@40117,COG0347@1,COG0347@2 NA|NA|NA K Nitrogen regulatory protein P-II PFHLONEA_00580 289376.THEYE_A1713 4.2e-36 157.5 Nitrospirae nifY ko:K02596 ko00000 Bacteria 3J1D3@40117,COG1433@1,COG1433@2 NA|NA|NA S Dinitrogenase iron-molybdenum cofactor PFHLONEA_00581 289376.THEYE_A1714 4.4e-76 291.6 Nitrospirae nifE ko:K02587,ko:K02592 ko00000 Bacteria 3J0WK@40117,COG2710@1,COG2710@2 NA|NA|NA C Nitrogenase component 1 type Oxidoreductase PFHLONEA_00582 289376.THEYE_A0465 1.7e-40 172.6 Nitrospirae nusG GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 ko:K02601,ko:K05785 ko00000,ko03000,ko03009,ko03021 Bacteria 3J17S@40117,COG0250@1,COG0250@2 NA|NA|NA K Transcription termination factor nusG PFHLONEA_00583 1157634.KB912945_gene3131 4.8e-31 141.7 Actinobacteria Bacteria 2H6C7@201174,COG0726@1,COG0726@2 NA|NA|NA G polysaccharide deacetylase PFHLONEA_00585 1174528.JH992893_gene5895 3.9e-59 235.0 Stigonemataceae acpS-2 2.7.8.7 ko:K00997,ko:K06133 ko00770,map00770 R01625 RC00002 ko00000,ko00001,ko01000 Bacteria 1G5GA@1117,1JH83@1189,COG2091@1,COG2091@2 NA|NA|NA H 4'-phosphopantetheinyl transferase superfamily PFHLONEA_00590 1396141.BATP01000019_gene1579 8e-48 197.2 Verrucomicrobiae CP_0318 ko:K06132 ko00564,ko01100,map00564,map01100 R11062 RC00017 ko00000,ko00001,ko01000 Bacteria 2IVBU@203494,46TDH@74201,COG1502@1,COG1502@2 NA|NA|NA I Phospholipase D. Active site motifs. PFHLONEA_00591 1232410.KI421426_gene1501 5.5e-147 527.3 Desulfuromonadales echE 1.6.5.3 ko:K00333,ko:K14090 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 1QUBF@1224,2WJ4E@28221,43DST@68525,43TGG@69541,COG3261@1,COG3261@2 NA|NA|NA C PFAM NADH-ubiquinone oxidoreductase, chain 49kDa PFHLONEA_00592 1232410.KI421426_gene1497 5.9e-35 153.7 Desulfuromonadales echD ko:K14089 ko00000 Bacteria 1RK19@1224,2WRJU@28221,42V29@68525,43VT5@69541,COG0852@1,COG0852@2 NA|NA|NA C Respiratory-chain NADH dehydrogenase, 30 Kd subunit PFHLONEA_00593 1232410.KI421426_gene1496 1.1e-59 236.1 Desulfuromonadales echC 1.6.5.3 ko:K00331,ko:K14088,ko:K14105 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 1QUBE@1224,2WNT3@28221,42NH3@68525,43UYP@69541,COG3260@1,COG3260@2 NA|NA|NA C PFAM NADH ubiquinone oxidoreductase 20 kDa subunit PFHLONEA_00596 1379698.RBG1_1C00001G0688 2e-27 128.3 unclassified Bacteria glmS GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 iAF987.Gmet_1487 Bacteria 2NNWC@2323,COG0449@1,COG0449@2 NA|NA|NA M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source PFHLONEA_00598 1380394.JADL01000020_gene1849 1.2e-76 294.3 Rhodospirillales lrsB Bacteria 1NEVR@1224,2JR0Q@204441,2V6PW@28211,COG1055@1,COG1055@2 NA|NA|NA P COG1055 Na H antiporter NhaD and related arsenite permeases PFHLONEA_00601 316067.Geob_3539 1.1e-138 500.0 Desulfuromonadales ispH 1.17.7.4 ko:K02945,ko:K03527 ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010 M00096,M00178 R05884,R08210 RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko03011 Bacteria 1N2EJ@1224,2WJ0A@28221,42NXS@68525,43TNQ@69541,COG0539@1,COG0539@2 NA|NA|NA J Ribosomal protein S1-like RNA-binding domain PFHLONEA_00602 243231.GSU3205 1.8e-120 439.5 Desulfuromonadales rimO GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016782,GO:0018193,GO:0018197,GO:0018198,GO:0018339,GO:0019538,GO:0035596,GO:0035599,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901564 2.8.4.4 ko:K14441 R10652 RC00003,RC03217 ko00000,ko01000,ko03009 Bacteria 1MU7N@1224,2WITA@28221,42MRJ@68525,43TZ3@69541,COG0621@1,COG0621@2 NA|NA|NA J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 PFHLONEA_00603 483219.LILAB_17575 1.5e-20 105.5 Myxococcales ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 ko00000,ko00001,ko03000 Bacteria 1NBX3@1224,2WQY8@28221,2YVI9@29,42UGQ@68525,COG0664@1,COG0664@2 NA|NA|NA T Cyclic nucleotide-monophosphate binding domain PFHLONEA_00607 589865.DaAHT2_0148 4.3e-46 191.0 Proteobacteria chrB Bacteria 1NN37@1224,COG0607@1,COG0607@2 NA|NA|NA P Rhodanese Homology Domain PFHLONEA_00609 1123257.AUFV01000002_gene2395 9.5e-115 420.6 Xanthomonadales ko:K07112 ko00000 Bacteria 1PF9B@1224,1SH3M@1236,1XBJT@135614,COG2391@1,COG2391@2 NA|NA|NA S Sulphur transport PFHLONEA_00610 396588.Tgr7_0064 1.1e-21 109.0 Gammaproteobacteria yedF GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0019725,GO:0033554,GO:0042592,GO:0048878,GO:0050896,GO:0051716,GO:0055082,GO:0065007,GO:0065008 ko:K04085,ko:K07112 ko04122,map04122 ko00000,ko00001,ko01000,ko03016 Bacteria 1QSN1@1224,1SS7P@1236,COG0425@1,COG0425@2 NA|NA|NA O Belongs to the sulfur carrier protein TusA family PFHLONEA_00612 1121918.ARWE01000001_gene2018 9.8e-10 70.9 Desulfuromonadales Bacteria 1QZ5N@1224,2X7RC@28221,4307W@68525,43UV3@69541,COG0745@1,COG0745@2 NA|NA|NA KT PilZ domain PFHLONEA_00613 469383.Cwoe_5515 8.3e-12 77.8 Actinobacteria Bacteria 2IQWH@201174,COG0745@1,COG0745@2 NA|NA|NA T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain PFHLONEA_00616 1054213.HMPREF9946_04386 3.6e-39 168.3 Rhodospirillales plsY 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 1RD4Z@1224,2JSK9@204441,2U7BZ@28211,COG0344@1,COG0344@2 NA|NA|NA I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP PFHLONEA_00617 330214.NIDE2558 1e-38 166.8 Nitrospirae pgsA 2.7.8.5 ko:K00995 ko00564,ko01100,map00564,map01100 R01801 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 iIT341.HP1016 Bacteria 3J0NH@40117,COG0558@1,COG0558@2 NA|NA|NA I CDP-alcohol phosphatidyltransferase PFHLONEA_00618 215803.DB30_3225 7e-47 194.5 Myxococcales lpxL GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006082,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008951,GO:0009058,GO:0009245,GO:0009247,GO:0009266,GO:0009311,GO:0009312,GO:0009409,GO:0009628,GO:0009987,GO:0016020,GO:0016051,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0019752,GO:0036103,GO:0036104,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046467,GO:0046493,GO:0050896,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.241,2.3.1.242,2.3.1.243 ko:K02517,ko:K02560,ko:K12974 ko00540,ko01100,map00540,map01100 M00060 R05075,R05146,R10906 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 iEC042_1314.EC042_2597,iECABU_c1320.ECABU_c21170,iECIAI39_1322.ECIAI39_1194,iSF_1195.SF1061,iS_1188.S1138,iYL1228.KPN_01068,ic_1306.c2269 Bacteria 1MVNI@1224,2WQ3X@28221,2YYM4@29,42N6U@68525,COG1560@1,COG1560@2 NA|NA|NA M Bacterial lipid A biosynthesis acyltransferase PFHLONEA_00619 1232410.KI421421_gene3584 1e-42 179.9 Desulfuromonadales kdsC 2.5.1.55,3.1.3.45 ko:K01627,ko:K03270 ko00540,ko01100,map00540,map01100 M00063 R03254,R03350 RC00017,RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 Bacteria 1RH85@1224,2WP0X@28221,42SN2@68525,43SHS@69541,COG1778@1,COG1778@2 NA|NA|NA S 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase PFHLONEA_00620 338963.Pcar_1943 2.6e-111 408.7 Desulfuromonadales kdsD 2.5.1.55,5.3.1.13 ko:K01627,ko:K03281,ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530,R03254 RC00435,RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 2.A.49 iAF987.Gmet_1278 Bacteria 1MUXD@1224,2WJ4Y@28221,42M0M@68525,43S6C@69541,COG0517@1,COG0517@2,COG0794@1,COG0794@2 NA|NA|NA M SIS domain PFHLONEA_00621 269799.Gmet_1277 5.5e-99 367.5 Desulfuromonadales kdsA GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005996,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008676,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016043,GO:0016051,GO:0016053,GO:0016740,GO:0016765,GO:0019294,GO:0019752,GO:0022607,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046394,GO:0046400,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 Bacteria 1MV91@1224,2WIXU@28221,42M61@68525,43TJ3@69541,COG2877@1,COG2877@2 NA|NA|NA F PFAM DAHP synthetase I KDSA PFHLONEA_00622 1379281.AVAG01000010_gene1338 1.6e-222 778.9 Desulfovibrionales pyrG GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1276,iECO103_1326.ECO103_3323,iNJ661.Rv1699,iPC815.YPO3377 Bacteria 1MUIT@1224,2M91M@213115,2WJ0F@28221,42MEU@68525,COG0504@1,COG0504@2 NA|NA|NA F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates PFHLONEA_00623 443144.GM21_2614 4.7e-61 241.1 Desulfuromonadales kdsB 2.7.7.38 ko:K00979 ko00540,ko01100,map00540,map01100 M00063 R03351,R11396 RC00152,RC00910 ko00000,ko00001,ko00002,ko01000,ko01005 Bacteria 1MUUU@1224,2WMQW@28221,42PTX@68525,43T2I@69541,COG1212@1,COG1212@2 NA|NA|NA F Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria PFHLONEA_00624 289376.THEYE_A1063 1.8e-50 205.3 Nitrospirae argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 iJN678.argG,iSB619.SA_RS04675 Bacteria 3J0BU@40117,COG0137@1,COG0137@2 NA|NA|NA E Belongs to the argininosuccinate synthase family. Type 1 subfamily PFHLONEA_00625 338963.Pcar_2418 6.5e-156 557.4 Desulfuromonadales argH GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,4.3.2.1 ko:K01755,ko:K14681 ko00220,ko00250,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map01100,map01110,map01130,map01210,map01230 M00028,M00029,M00844,M00845 R00259,R01086 RC00004,RC00064,RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1MUTU@1224,2WIRN@28221,42M7Y@68525,43RY2@69541,COG0165@1,COG0165@2 NA|NA|NA E Argininosuccinate lyase C-terminal PFHLONEA_00626 671143.DAMO_0087 6.6e-52 211.5 unclassified Bacteria Bacteria 2NQ62@2323,COG4733@1,COG4733@2 NA|NA|NA S Fibronectin type 3 domain PFHLONEA_00627 289376.THEYE_A1133 1e-144 520.0 Nitrospirae lysA GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008836,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.1.129,3.4.16.4,4.1.1.20 ko:K01586,ko:K05366 ko00300,ko00550,ko01100,ko01110,ko01120,ko01130,ko01230,ko01501,map00300,map00550,map01100,map01110,map01120,map01130,map01230,map01501 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000,ko01003,ko01011 GT51 iLJ478.TM1517 Bacteria 3J0CR@40117,COG0019@1,COG0019@2 NA|NA|NA E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine PFHLONEA_00628 880072.Desac_2488 1.4e-73 283.1 Syntrophobacterales dapF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 iIT341.HP0566,iLJ478.TM1522 Bacteria 1MWDH@1224,2MQD5@213462,2WMP4@28221,42MRX@68525,COG0253@1,COG0253@2 NA|NA|NA E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan PFHLONEA_00631 909663.KI867150_gene214 8.2e-71 275.0 Syntrophobacterales Bacteria 1NNJ6@1224,2MRCI@213462,2WKWJ@28221,42PBD@68525,COG0457@1,COG0457@2,COG1807@1,COG1807@2 NA|NA|NA M PFAM Tetratricopeptide repeat PFHLONEA_00632 1123376.AUIU01000011_gene1105 3e-93 348.6 Nitrospirae acuC Bacteria 3J0P2@40117,COG0123@1,COG0123@2 NA|NA|NA BQ Histone deacetylase domain PFHLONEA_00633 404380.Gbem_1106 1.9e-07 63.2 Desulfuromonadales Bacteria 1NFQW@1224,2WKWA@28221,42MT2@68525,43TXB@69541,COG0457@1,COG0457@2 NA|NA|NA S PFAM Tetratricopeptide TPR_1 repeat-containing protein PFHLONEA_00634 243231.GSU2493 1.4e-66 260.0 Deltaproteobacteria Bacteria 1NUYI@1224,2WV3C@28221,42ZRG@68525,COG3391@1,COG3391@2 NA|NA|NA S amine dehydrogenase activity PFHLONEA_00635 316067.Geob_3159 1.5e-87 330.1 Desulfuromonadales pccJ Bacteria 1RG8Q@1224,2WNP8@28221,42S2W@68525,43V2D@69541,COG3043@1,COG3043@2 NA|NA|NA C Doubled CXXCH motif (Paired_CXXCH_1) PFHLONEA_00636 243231.GSU2495 4.1e-31 143.3 Desulfuromonadales Bacteria 1QXP6@1224,2X7FE@28221,43C52@68525,43W47@69541,COG3043@1,COG3043@2 NA|NA|NA C Cytochrome c3 PFHLONEA_00637 316067.Geob_3161 1.5e-93 350.5 Deltaproteobacteria Bacteria 1NQ2Y@1224,2WSSQ@28221,42XX8@68525,COG0760@1,COG0760@2 NA|NA|NA O PPIC-type PPIASE domain PFHLONEA_00638 909943.HIMB100_00003600 3.9e-34 152.9 Proteobacteria ydhQ GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716 2.7.11.1 ko:K07346,ko:K12132 ko00000,ko01000,ko01001,ko02035,ko02044,ko03110 Bacteria 1QUZ3@1224,COG3121@1,COG3121@2,COG3468@1,COG3468@2 NA|NA|NA MU heme binding PFHLONEA_00644 382464.ABSI01000005_gene1294 5.2e-37 162.2 Verrucomicrobiae rapK GO:0003674,GO:0003824,GO:0016787,GO:0016801,GO:0016803 3.3.2.13,4.1.3.40,4.1.3.45 ko:K18239,ko:K18240 ko00130,ko00400,ko01100,ko01110,map00130,map00400,map01100,map01110 M00117 R01302,R10583,R10597 RC00350,RC00491,RC02148,RC03212 ko00000,ko00001,ko00002,ko01000 Bacteria 2IW47@203494,46V5Y@74201,COG0251@1,COG0251@2 NA|NA|NA J Endoribonuclease L-PSP PFHLONEA_00645 929558.SMGD1_1759 1.7e-21 109.4 delta/epsilon subdivisions GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03286,ko:K10936 ko05111,map05111 ko00000,ko00001,ko02000 1.B.6 Bacteria 1NE9Q@1224,4331N@68525,COG3637@1,COG3637@2 NA|NA|NA M Outer membrane protein beta-barrel domain PFHLONEA_00646 1125863.JAFN01000001_gene2796 5.1e-07 60.1 Deltaproteobacteria pcmB Bacteria 1MU2H@1224,2WMEM@28221,42PJ7@68525,COG0493@1,COG0493@2 NA|NA|NA C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster PFHLONEA_00647 1125863.JAFN01000001_gene2795 1.2e-29 136.3 Deltaproteobacteria 1.10.9.1 ko:K02636,ko:K03886 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00151,M00162 R03817,R08409 RC01002 ko00000,ko00001,ko00002,ko00194,ko01000 Bacteria 1NINP@1224,2WRHY@28221,42VKD@68525,COG0723@1,COG0723@2 NA|NA|NA C PFAM Rieske 2Fe-2S domain PFHLONEA_00649 932678.THERU_01595 4.6e-12 77.8 Aquificae Bacteria 2E20Q@1,2G53C@200783,32X8P@2 NA|NA|NA PFHLONEA_00650 1123376.AUIU01000012_gene1488 4.1e-12 77.8 Bacteria Bacteria 2E20Q@1,32X8P@2 NA|NA|NA PFHLONEA_00651 289376.THEYE_A1544 3.6e-49 201.4 Nitrospirae frr GO:0002181,GO:0002184,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0030312,GO:0032984,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02838 ko00000,ko03012 Bacteria 3J0KJ@40117,COG0233@1,COG0233@2 NA|NA|NA J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another PFHLONEA_00652 1232410.KI421418_gene2263 1e-93 349.7 Desulfuromonadales pyrH GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006225,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009163,GO:0009165,GO:0009185,GO:0009188,GO:0009193,GO:0009194,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0033862,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042455,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046048,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046872,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 R00158 RC00002 ko00000,ko00001,ko01000 iSB619.SA_RS06240 Bacteria 1MV3N@1224,2WJDF@28221,42M3X@68525,43SW0@69541,COG0528@1,COG0528@2 NA|NA|NA F Catalyzes the reversible phosphorylation of UMP to UDP PFHLONEA_00653 1163617.SCD_n01634 1.6e-76 293.1 Betaproteobacteria tsf GO:0001871,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005085,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0019538,GO:0019899,GO:0030246,GO:0030247,GO:0034641,GO:0034645,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051020,GO:0065007,GO:0065009,GO:0071704,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065 ko:K02357 ko00000,ko03012,ko03029 Bacteria 1MUS2@1224,2VHSG@28216,COG0264@1,COG0264@2 NA|NA|NA J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome PFHLONEA_00654 1121918.ARWE01000001_gene1940 2.4e-50 205.3 Desulfuromonadales rpsB GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02967 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1MU33@1224,2WJH5@28221,42M3Y@68525,43S78@69541,COG0052@1,COG0052@2 NA|NA|NA J Ribosomal protein S2 PFHLONEA_00655 1162668.LFE_1520 6.7e-30 136.3 Nitrospirae groS GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010033,GO:0016032,GO:0016465,GO:0019058,GO:0019068,GO:0032991,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051704,GO:0061077,GO:0101031,GO:1990220 ko:K04078 ko00000,ko03029,ko03110 Bacteria 3J0RF@40117,COG0234@1,COG0234@2 NA|NA|NA O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter PFHLONEA_00656 289376.THEYE_A1481 7.9e-114 417.5 Nitrospirae ctpA 3.4.21.102 ko:K03797 ko00000,ko01000,ko01002 Bacteria 3J09Y@40117,COG0793@1,COG0793@2 NA|NA|NA M tail specific protease PFHLONEA_00657 671143.DAMO_2529 1.9e-58 233.4 unclassified Bacteria envC GO:0000920,GO:0001896,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008219,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0012501,GO:0016020,GO:0016787,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0042546,GO:0042597,GO:0043085,GO:0044085,GO:0044093,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071554,GO:0071840,GO:0071944 ko:K21471 ko00000,ko01000,ko01002,ko01011 Bacteria 2NPDY@2323,COG4942@1,COG4942@2 NA|NA|NA D Peptidase family M23 PFHLONEA_00658 269799.Gmet_1855 3.1e-45 189.1 Desulfuromonadales ftsX GO:0005575,GO:0005618,GO:0005623,GO:0006928,GO:0008150,GO:0009274,GO:0009276,GO:0009605,GO:0009607,GO:0009615,GO:0009987,GO:0030312,GO:0030313,GO:0031975,GO:0040011,GO:0043207,GO:0044464,GO:0048870,GO:0050896,GO:0051179,GO:0051301,GO:0051674,GO:0051704,GO:0051707,GO:0071944,GO:0071976 ko:K09811,ko:K09812 ko02010,map02010 M00256 ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 Bacteria 1MU65@1224,2X6QG@28221,43BBA@68525,43T0S@69541,COG2177@1,COG2177@2 NA|NA|NA D Part of the ABC transporter FtsEX involved in cellular division PFHLONEA_00659 290397.Adeh_0666 1.7e-64 252.7 Myxococcales ftsE GO:0000166,GO:0000287,GO:0000910,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0007049,GO:0008144,GO:0008150,GO:0008356,GO:0009898,GO:0009966,GO:0009987,GO:0010646,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019897,GO:0019898,GO:0022402,GO:0022603,GO:0022607,GO:0023051,GO:0030145,GO:0030554,GO:0031234,GO:0032153,GO:0032506,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042173,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043937,GO:0043938,GO:0044085,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0046677,GO:0046872,GO:0046914,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051301,GO:0065007,GO:0070297,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363,GO:1902531 ko:K09811,ko:K09812 ko02010,map02010 M00256 ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 Bacteria 1MVQ4@1224,2WK4Y@28221,2YV0E@29,42MAM@68525,COG2884@1,COG2884@2 NA|NA|NA D ABC transporter PFHLONEA_00660 269799.Gmet_0552 8e-110 403.7 Desulfuromonadales tktB 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 Bacteria 1N6QF@1224,2WKF7@28221,42Q04@68525,43S5A@69541,COG3958@1,COG3958@2 NA|NA|NA G Transketolase, pyrimidine binding domain PFHLONEA_00661 1123376.AUIU01000015_gene456 1.5e-99 369.4 Nitrospirae tktA 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 Bacteria 3J1FM@40117,COG3959@1,COG3959@2 NA|NA|NA G Dehydrogenase E1 component PFHLONEA_00662 269799.Gmet_0550 1.5e-18 99.4 Deltaproteobacteria Bacteria 1R3K5@1224,2ET40@1,2X8RQ@28221,33KN7@2,43DKI@68525 NA|NA|NA PFHLONEA_00664 1125863.JAFN01000001_gene3430 8.3e-17 93.2 Bacteria arsR 3.6.4.12 ko:K03655,ko:K03892,ko:K21903 ko03440,map03440 ko00000,ko00001,ko01000,ko03000,ko03400 Bacteria COG0640@1,COG0640@2 NA|NA|NA K DNA-binding transcription factor activity PFHLONEA_00666 644966.Tmar_0255 2e-66 259.2 Firmicutes yrkJ ko:K07090 ko00000 Bacteria 1TRIE@1239,COG0730@1,COG0730@2 NA|NA|NA S membrane transporter protein PFHLONEA_00667 330214.NIDE3221 1.1e-73 283.9 Bacteria Bacteria COG3005@1,COG3005@2 NA|NA|NA C denitrification pathway PFHLONEA_00669 573063.Metin_1213 6.2e-07 60.5 Methanococci ko:K06039,ko:K07235 ko04122,map04122 ko00000,ko00001,ko01000,ko03016 Archaea 23R0A@183939,2XYJ8@28890,COG1553@1,arCOG02068@2157 NA|NA|NA P PFAM DsrE family protein PFHLONEA_00671 589865.DaAHT2_2661 3.3e-129 468.4 Desulfobacterales sqr GO:0003674,GO:0003824,GO:0003955,GO:0005488,GO:0005515,GO:0006091,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0019646,GO:0022900,GO:0022904,GO:0042802,GO:0044237,GO:0045333,GO:0055114 1.8.5.4 ko:K17218 ko00920,map00920 R10152 RC03155 ko00000,ko00001,ko01000 Bacteria 1QSGB@1224,2MP72@213118,2WZXC@28221,43A36@68525,COG0446@1,COG0446@2 NA|NA|NA S Pyridine nucleotide-disulphide oxidoreductase PFHLONEA_00672 666684.AfiDRAFT_1073 1.5e-30 139.8 Alphaproteobacteria Bacteria 1MYPU@1224,2UD81@28211,COG0500@1,COG2226@2 NA|NA|NA H Methyltransferase domain PFHLONEA_00673 316067.Geob_3713 1.2e-35 156.8 Desulfuromonadales nifZ 5.2.1.8 ko:K02597,ko:K03769,ko:K03771 ko00000,ko01000,ko03110 Bacteria 1MVB3@1224,2WMN3@28221,42QXH@68525,43TFD@69541,COG0760@1,COG0760@2 NA|NA|NA M SurA N-terminal domain PFHLONEA_00674 1304880.JAGB01000001_gene801 9.9e-102 377.1 Clostridia rlmI 2.1.1.191,2.1.1.72 ko:K00571,ko:K06969 ko00000,ko01000,ko02048,ko03009 Bacteria 1TRAJ@1239,247TI@186801,COG1092@1,COG1092@2 NA|NA|NA J SMART PUA domain containing protein PFHLONEA_00677 192952.MM_2340 1e-216 759.6 Euryarchaeota 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 Archaea 2XT1P@28890,COG0028@1,arCOG02002@2157 NA|NA|NA E Belongs to the TPP enzyme family PFHLONEA_00678 192952.MM_2341 6.1e-152 544.3 Methanomicrobia gabD 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 iAF692.Mbar_A2542 Archaea 2NA9G@224756,2XT1Y@28890,COG1012@1,arCOG01252@2157 NA|NA|NA C PFAM Aldehyde dehydrogenase PFHLONEA_00679 335543.Sfum_2105 6e-142 510.8 Syntrophobacterales 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1MUKX@1224,2MRE9@213462,2WJAN@28221,42N8U@68525,COG0372@1,COG0372@2 NA|NA|NA C Belongs to the citrate synthase family PFHLONEA_00680 1232410.KI421419_gene2478 2.6e-282 977.6 Desulfuromonadales acnA 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2763 Bacteria 1MU9T@1224,2WIIV@28221,42N5M@68525,43RYP@69541,COG1048@1,COG1048@2 NA|NA|NA C Aconitase C-terminal domain PFHLONEA_00681 1163617.SCD_n00707 9.2e-126 456.8 Betaproteobacteria Bacteria 1R5HW@1224,2VZ99@28216,COG1361@1,COG1361@2 NA|NA|NA M Protein of unknown function (DUF1566) PFHLONEA_00682 909663.KI867150_gene1250 1.1e-31 142.9 Syntrophobacterales suhB GO:0003674,GO:0003824,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0042578,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616 3.1.3.25,3.1.3.7 ko:K01082,ko:K01092 ko00521,ko00562,ko00920,ko01100,ko01120,ko01130,ko04070,map00521,map00562,map00920,map01100,map01120,map01130,map04070 M00131 R00188,R00508,R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000,ko03016 Bacteria 1MUQT@1224,2MR8P@213462,2WMQ4@28221,42R1W@68525,COG0483@1,COG0483@2 NA|NA|NA G PFAM inositol monophosphatase PFHLONEA_00686 404380.Gbem_3258 2.5e-133 482.3 Desulfuromonadales aroA GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 1.3.1.12,1.3.1.43,2.5.1.19 ko:K00210,ko:K00220,ko:K00800 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00022,M00025,M00040 R00732,R01728,R03460 RC00125,RC00350 ko00000,ko00001,ko00002,ko01000 iLJ478.TM0345 Bacteria 1MWMK@1224,2WKJQ@28221,42N01@68525,43TXZ@69541,COG0128@1,COG0128@2 NA|NA|NA E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate PFHLONEA_00687 1232410.KI421418_gene2305 1.2e-50 206.5 Desulfuromonadales aroA GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009095,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019438,GO:0019752,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0047794,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.3.1.12,1.3.1.43,2.5.1.19 ko:K00210,ko:K00220,ko:K00800,ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00022,M00025,M00040 R00732,R01728,R03460 RC00125,RC00350 ko00000,ko00001,ko00002,ko01000 Bacteria 1QTZA@1224,2WJZ7@28221,42MH0@68525,43S3M@69541,COG0287@1,COG0287@2 NA|NA|NA E Prephenate dehydrogenase PFHLONEA_00691 1217705.F900_00695 2.3e-36 159.1 Gammaproteobacteria Bacteria 1RHIM@1224,1S49C@1236,COG1974@1,COG1974@2 NA|NA|NA K repressor PFHLONEA_00694 551895.B5AX23_9CAUD 2.9e-24 119.0 Myoviridae Viruses 4QFSY@10239,4QKD8@10662,4QQ9N@28883,4QW2R@35237 NA|NA|NA PFHLONEA_00695 880072.Desac_1503 4.1e-221 774.2 Syntrophobacterales clpB GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 ko:K03694,ko:K03695 ko04213,map04213 ko00000,ko00001,ko03110 Bacteria 1MURH@1224,2MQ8A@213462,2WJSZ@28221,42M9S@68525,COG0542@1,COG0542@2 NA|NA|NA O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE PFHLONEA_00696 443144.GM21_2649 6.1e-42 177.2 Desulfuromonadales femD 5.4.2.2,5.4.2.8 ko:K01835,ko:K01840 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114,M00549 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 Bacteria 1QUGD@1224,2WKYP@28221,43BUU@68525,43STX@69541,COG1109@1,COG1109@2 NA|NA|NA G phosphoglucomutase phosphomannomutase alpha beta alpha domain I PFHLONEA_00697 349161.Dred_2987 5.1e-176 624.0 Peptococcaceae eno 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 Bacteria 1TP2S@1239,247TU@186801,2600A@186807,COG0148@1,COG0148@2 NA|NA|NA G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis PFHLONEA_00698 1125863.JAFN01000001_gene2430 5e-16 90.5 Deltaproteobacteria MA20_43655 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 Bacteria 1R1JS@1224,2X8GN@28221,43EIB@68525,COG3824@1,COG3824@2 NA|NA|NA S Zincin-like metallopeptidase PFHLONEA_00699 1125863.JAFN01000001_gene3040 2.7e-45 188.3 Deltaproteobacteria hldE GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016772,GO:0019200,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.1.167,2.7.7.70 ko:K03272 ko00540,ko01100,map00540,map01100 M00064 R05644,R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 iAF987.Gmet_0922 Bacteria 1REW3@1224,2WPTP@28221,42SGQ@68525,COG0615@1,COG0615@2 NA|NA|NA H Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose PFHLONEA_00700 1484157.PSNIH2_22190 8.7e-67 261.2 Pantoea ko:K07497 ko00000 Bacteria 1MWVQ@1224,1RN12@1236,3W1GD@53335,COG2801@1,COG2801@2,COG3415@1,COG3415@2 NA|NA|NA L Helix-turn-helix domain PFHLONEA_00701 1125863.JAFN01000001_gene2653 7.8e-52 212.2 Deltaproteobacteria Bacteria 1MZV7@1224,2WPGK@28221,42PVX@68525,COG2199@1,COG3706@2 NA|NA|NA T diguanylate cyclase PFHLONEA_00702 264462.Bd0743 2.7e-30 138.7 Bdellovibrionales ko:K03088 ko00000,ko03021 Bacteria 1MX7T@1224,2MUR4@213481,2WQA9@28221,42U04@68525,COG1595@1,COG1595@2 NA|NA|NA K Belongs to the sigma-70 factor family. ECF subfamily PFHLONEA_00704 671143.DAMO_2843 8.1e-10 70.9 unclassified Bacteria Bacteria 2DGXT@1,2NRPI@2323,2ZXPG@2 NA|NA|NA PFHLONEA_00705 338966.Ppro_2008 6.7e-17 94.4 Desulfuromonadales ko:K06940 ko00000 Bacteria 1REPM@1224,2WNSE@28221,42RPZ@68525,43UMY@69541,COG0727@1,COG0727@2 NA|NA|NA S Putative zinc- or iron-chelating domain PFHLONEA_00706 404589.Anae109_2759 2.9e-56 225.3 delta/epsilon subdivisions ko:K02305 ko00910,ko01120,map00910,map01120 M00529 R00294 RC02794 ko00000,ko00001,ko00002 3.D.4.10 Bacteria 1RDSI@1224,42WEW@68525,COG2010@1,COG2010@2 NA|NA|NA C cytochrome c PFHLONEA_00708 582899.Hden_2835 1.6e-18 99.4 Bacteria Bacteria COG4232@1,COG4232@2 NA|NA|NA CO protein-disulfide reductase activity PFHLONEA_00709 289376.THEYE_A0216 4.4e-17 94.4 Bacteria Bacteria 2DU0J@1,32UW9@2 NA|NA|NA PFHLONEA_00710 945713.IALB_1398 1.7e-53 216.5 Bacteria ctaB GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008495,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 Bacteria COG0109@1,COG0109@2 NA|NA|NA O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group PFHLONEA_00711 1232410.KI421415_gene2988 3.7e-81 308.5 Desulfuromonadales coxB GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.9.3.1 ko:K02275,ko:K17223 ko00190,ko00920,ko01100,ko01120,map00190,map00920,map01100,map01120 M00155,M00595 R00081,R10151 RC00016,RC03151,RC03152 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 Bacteria 1MWHZ@1224,2WM4F@28221,42M7N@68525,43T32@69541,COG1622@1,COG1622@2,COG2010@1,COG2010@2 NA|NA|NA C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) PFHLONEA_00712 1232410.KI421415_gene2987 4.3e-14 84.0 Desulfuromonadales coxD 1.9.3.1 ko:K02277 ko00190,ko01100,map00190,map01100 M00155 ko00000,ko00001,ko00002,ko01000 3.D.4.4 Bacteria 1NA2T@1224,2EAMQ@1,2WRD9@28221,334Q9@2,42VC9@68525,43SRT@69541 NA|NA|NA S Prokaryotic Cytochrome C oxidase subunit IV PFHLONEA_00714 945713.IALB_1395 4e-62 244.6 Bacteria coxC 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 Bacteria COG1845@1,COG1845@2 NA|NA|NA C cytochrome c oxidase, subunit III PFHLONEA_00715 269799.Gmet_0249 1.2e-214 752.7 Desulfuromonadales ctaD 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 Bacteria 1MU7S@1224,2WJUK@28221,42M18@68525,43S0R@69541,COG0843@1,COG0843@2 NA|NA|NA C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B PFHLONEA_00716 207559.Dde_1822 6.3e-60 237.7 Desulfovibrionales sco ko:K07152 ko00000,ko03029 Bacteria 1R9EM@1224,2M9V6@213115,2WKG7@28221,42N5F@68525,COG1999@1,COG1999@2 NA|NA|NA S protein SCO1 SenC PrrC involved in biogenesis of respiratory and photosynthetic systems PFHLONEA_00717 395494.Galf_1156 4.7e-134 484.6 Nitrosomonadales fabF_1 GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0016740,GO:0016746,GO:0016747,GO:0033817 2.3.1.179 ko:K09458,ko:K14660 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 1MV30@1224,2VI0P@28216,44VP8@713636,COG0304@1,COG0304@2 NA|NA|NA I Beta-ketoacyl synthase, C-terminal domain PFHLONEA_00718 395494.Galf_1157 3.6e-14 84.0 Nitrosomonadales ko:K02078 ko00000,ko00001 Bacteria 1NGVI@1224,2VXRY@28216,44W32@713636,COG0236@1,COG0236@2 NA|NA|NA IQ Phosphopantetheine attachment site PFHLONEA_00719 247490.KSU1_B0190 8e-162 577.0 Bacteria Bacteria COG1032@1,COG1032@2 NA|NA|NA C radical SAM domain protein PFHLONEA_00721 1379698.RBG1_1C00001G0016 7.6e-104 384.4 unclassified Bacteria ko:K07713 ko02020,map02020 M00499 ko00000,ko00001,ko00002,ko02022 Bacteria 2NNPN@2323,COG2204@1,COG2204@2 NA|NA|NA T COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains PFHLONEA_00722 1123371.ATXH01000032_gene441 2.6e-31 142.1 Thermodesulfobacteria Bacteria 2CA4A@1,2GH7R@200940,32RQK@2 NA|NA|NA S Domain of unknown function (DUF4416) PFHLONEA_00723 589865.DaAHT2_0174 2.4e-25 122.1 Desulfobacterales ko:K13771 ko05132,map05132 ko00000,ko00001,ko03000 Bacteria 1MZ1C@1224,2MM91@213118,2WPVC@28221,42SPF@68525,COG1959@1,COG1959@2 NA|NA|NA K TIGRFAM transcriptional regulator, Rrf2 family PFHLONEA_00726 243231.GSU2017 2.9e-47 195.7 Desulfuromonadales mqnA 1.21.98.1,4.2.1.151 ko:K07081,ko:K11782,ko:K11784 ko00130,ko01110,map00130,map01110 R08588,R10666 RC02329,RC03232 ko00000,ko00001,ko01000 Bacteria 1RCS0@1224,2WP7F@28221,42SPW@68525,43U6I@69541,COG1427@1,COG1427@2 NA|NA|NA H Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) PFHLONEA_00729 635013.TherJR_1133 1.3e-47 196.4 Peptococcaceae cysG 1.3.1.76,4.99.1.4 ko:K02304 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03947 RC01012,RC01034 ko00000,ko00001,ko00002,ko01000 Bacteria 1VA2E@1239,24N6M@186801,2625C@186807,COG1648@1,COG1648@2 NA|NA|NA H TIGRFAM siroheme synthase PFHLONEA_00731 269799.Gmet_2920 9.9e-171 607.1 Deltaproteobacteria Bacteria 1NAE1@1224,28J7E@1,2WJXV@28221,2Z92U@2,42P08@68525 NA|NA|NA S Domain of unknown function (DUF4105) PFHLONEA_00732 443143.GM18_3817 1.7e-42 179.1 Deltaproteobacteria Bacteria 1N17Y@1224,2DMP9@1,2WQHJ@28221,32SV1@2,42TQF@68525 NA|NA|NA S Protein of unknown function (DUF3015) PFHLONEA_00734 269799.Gmet_2922 6e-80 304.3 Deltaproteobacteria yfhR ko:K06889 ko00000 Bacteria 1RFAF@1224,2X601@28221,43AJV@68525,COG1073@1,COG1073@2 NA|NA|NA S Alpha/beta hydrolase family PFHLONEA_00735 123214.PERMA_0018 4.7e-39 167.5 Aquificae dtd GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106026,GO:0106074,GO:0140098,GO:0140101,GO:1901360 ko:K07560 ko00000,ko01000,ko03016 Bacteria 2G477@200783,COG1490@1,COG1490@2 NA|NA|NA J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality PFHLONEA_00736 338963.Pcar_2022 9.8e-80 303.9 Desulfuromonadales rlmN GO:0000049,GO:0000154,GO:0001510,GO:0002935,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016426,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0070040,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:0140102,GO:1901360,GO:1901363 2.1.1.192 ko:K06941 ko00000,ko01000,ko03009 Bacteria 1MUYK@1224,2WIUJ@28221,42N69@68525,43S0V@69541,COG0820@1,COG0820@2 NA|NA|NA J Radical SAM superfamily PFHLONEA_00738 933262.AXAM01000051_gene2970 1.1e-36 159.8 Desulfobacterales rluD GO:0000027,GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022607,GO:0022613,GO:0022618,GO:0031118,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 5.4.99.23,5.4.99.28,5.4.99.29 ko:K06177,ko:K06180 ko00000,ko01000,ko03009,ko03016 iE2348C_1286.E2348C_2868,iECED1_1282.ECED1_3035,iECSF_1327.ECSF_2432 Bacteria 1MUBN@1224,2MI4G@213118,2WKX9@28221,42MBA@68525,COG0564@1,COG0564@2 NA|NA|NA J Responsible for synthesis of pseudouridine from uracil PFHLONEA_00739 880072.Desac_1507 5.2e-12 77.4 Syntrophobacterales Bacteria 1QWWG@1224,2MR75@213462,2WK6G@28221,42PD6@68525,COG1538@1,COG1538@2 NA|NA|NA MU PFAM Outer membrane efflux protein PFHLONEA_00740 243274.THEMA_02165 1.6e-71 276.6 Thermotogae oppD ko:K02031,ko:K02032,ko:K15583 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 iLJ478.TM0058,iLJ478.TM1064,iLJ478.TM1194,iLJ478.TM1220,iLJ478.TM1749 Bacteria 2GCKF@200918,COG0444@1,COG0444@2 NA|NA|NA P Belongs to the ABC transporter superfamily PFHLONEA_00741 411467.BACCAP_03757 7.2e-44 184.5 unclassified Clostridiales dppCch3 ko:K02034 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 1TP4R@1239,2489T@186801,268YC@186813,COG1173@1,COG1173@2 NA|NA|NA P ABC transporter, permease protein PFHLONEA_00742 720555.BATR1942_03330 3.1e-48 199.1 Bacillus oppB GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 ko:K02033 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 1TP1S@1239,1ZCAV@1386,4HATR@91061,COG0601@1,COG0601@2 NA|NA|NA P COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components PFHLONEA_00743 1125863.JAFN01000001_gene2822 4e-109 402.1 Deltaproteobacteria ko:K02035 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 1MUZH@1224,2WKBU@28221,42MFK@68525,COG0747@1,COG0747@2 NA|NA|NA E extracellular solute-binding protein, family 5 PFHLONEA_00746 1121918.ARWE01000001_gene1142 3.7e-62 245.4 Desulfuromonadales ylbK GO:0003674,GO:0003824,GO:0016787 ko:K07001 ko00000 Bacteria 1MUM9@1224,2WMYB@28221,42URW@68525,43SFS@69541,COG1752@1,COG1752@2 NA|NA|NA S Patatin-like phospholipase PFHLONEA_00747 655815.ZPR_4213 5.9e-25 121.3 Flavobacteriia ugpQ 3.1.4.46 ko:K01126 ko00564,map00564 R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 Bacteria 1HYHS@117743,4NGNU@976,COG0584@1,COG0584@2 NA|NA|NA C glycerophosphoryl diester phosphodiesterase PFHLONEA_00748 525904.Tter_0471 2e-105 389.8 unclassified Bacteria glpD 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 R00848 RC00029 ko00000,ko00001,ko01000 iJN678.glpD Bacteria 2NP90@2323,COG0578@1,COG0578@2 NA|NA|NA C C-terminal domain of alpha-glycerophosphate oxidase PFHLONEA_00749 391612.CY0110_28224 1.3e-28 132.9 Bacteria Bacteria 2DBIE@1,32TXH@2 NA|NA|NA PFHLONEA_00750 264732.Moth_1516 1.1e-68 266.9 Thermoanaerobacterales folD GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1162 Bacteria 1TP1P@1239,248DB@186801,42FHP@68295,COG0190@1,COG0190@2 NA|NA|NA F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate PFHLONEA_00751 1519464.HY22_08900 8.1e-30 137.1 Bacteria ko:K07088 ko00000 Bacteria COG0679@1,COG0679@2 NA|NA|NA S auxin-activated signaling pathway PFHLONEA_00753 909663.KI867150_gene2218 4.4e-70 271.6 Deltaproteobacteria nagA 3.5.1.25 ko:K01443,ko:K16786,ko:K16787 ko00520,ko01130,ko02010,map00520,map01130,map02010 M00582 R02059 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 Bacteria 1MW8Y@1224,2WVQI@28221,430VJ@68525,COG1820@1,COG1820@2 NA|NA|NA G Belongs to the metallo-dependent hydrolases superfamily. NagA family PFHLONEA_00754 243231.GSU2192 5.6e-38 164.5 Desulfuromonadales gph 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 R01334 RC00017 ko00000,ko00001,ko01000 Bacteria 1RDDY@1224,2WQMY@28221,42USC@68525,43UZV@69541,COG0546@1,COG0546@2 NA|NA|NA S HAD-superfamily hydrolase, subfamily IA, variant 3 PFHLONEA_00755 243231.GSU2502 1.4e-25 123.2 Deltaproteobacteria speE GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 Bacteria 1QX98@1224,2X7CZ@28221,43C2D@68525,COG0421@1,COG0421@2 NA|NA|NA E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine PFHLONEA_00756 395961.Cyan7425_4809 3.3e-46 192.2 Cyanothece Bacteria 1G5BB@1117,3KGBC@43988,COG2199@1,COG3706@2 NA|NA|NA T PFAM GGDEF domain containing protein PFHLONEA_00757 1157490.EL26_19350 2.9e-156 559.3 Alicyclobacillaceae Bacteria 1TP8V@1239,2798R@186823,4HA3G@91061,COG5001@1,COG5001@2 NA|NA|NA T Putative diguanylate phosphodiesterase PFHLONEA_00760 56780.SYN_01716 1.4e-31 142.9 Syntrophobacterales pgsA-2 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 Bacteria 1MZ8B@1224,2MQP8@213462,2WQC4@28221,42TIF@68525,COG0558@1,COG0558@2 NA|NA|NA I CDP-alcohol phosphatidyltransferase PFHLONEA_00761 909663.KI867150_gene2427 2.5e-132 479.9 Syntrophobacterales Bacteria 1RCM9@1224,2MR4H@213462,2WIU5@28221,42MC4@68525,COG4191@1,COG4191@2 NA|NA|NA T His Kinase A (phosphoacceptor) domain PFHLONEA_00764 1379698.RBG1_1C00001G1089 1.3e-82 313.9 unclassified Bacteria Bacteria 2NP8B@2323,COG3437@1,COG3437@2 NA|NA|NA T metal-dependent phosphohydrolase HD region PFHLONEA_00765 880072.Desac_0440 3.9e-47 196.1 Deltaproteobacteria 2.7.13.3 ko:K07709 ko02020,map02020 M00499 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 1P0U1@1224,2WJ8U@28221,42PTP@68525,COG4191@1,COG4191@2 NA|NA|NA T PFAM ATP-binding region, ATPase domain protein PFHLONEA_00767 247490.KSU1_D0599 1.1e-45 191.8 Planctomycetes Bacteria 2IYZD@203682,COG4191@1,COG4191@2 NA|NA|NA T Histidine kinase PFHLONEA_00768 292459.STH3046 2.2e-32 145.2 Clostridia rplQ GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02879,ko:K16193 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V6JQ@1239,24J9T@186801,COG0203@1,COG0203@2 NA|NA|NA J ribosomal protein l17 PFHLONEA_00769 404589.Anae109_1938 1.7e-72 279.3 Myxococcales rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 Bacteria 1MU75@1224,2WJ5K@28221,2YXN1@29,42MIX@68525,COG0202@1,COG0202@2 NA|NA|NA K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates PFHLONEA_00770 696281.Desru_0620 1.6e-10 73.2 Peptococcaceae Bacteria 1VDJZ@1239,24PIT@186801,265S4@186807,COG1413@1,COG1413@2 NA|NA|NA C HEAT-like repeat PFHLONEA_00771 1232410.KI421424_gene1758 3.5e-132 478.4 Deltaproteobacteria ko:K00185 ko00000 5.A.3 Bacteria 1PFX4@1224,2WJHN@28221,42NUN@68525,COG5557@1,COG5557@2 NA|NA|NA C PFAM Polysulphide reductase, NrfD PFHLONEA_00772 56780.SYN_02954 2.9e-158 564.7 Syntrophobacterales fbaA GO:0003674,GO:0003824,GO:0004332,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016830,GO:0016832,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035375,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 iZ_1308.Z4263 Bacteria 1MURX@1224,2MRHZ@213462,2WJCJ@28221,42MK7@68525,COG0191@1,COG0191@2 NA|NA|NA G Fructose-bisphosphate aldolase class-II PFHLONEA_00773 56780.SYN_02953 1.5e-188 665.6 Deltaproteobacteria pfkA 2.7.1.11 ko:K00850 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 Bacteria 1MVN3@1224,2WIZ0@28221,42NMZ@68525,COG0205@1,COG0205@2 NA|NA|NA G Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP- dependent clade X sub-subfamily PFHLONEA_00776 478749.BRYFOR_07898 6.1e-49 201.4 Clostridia stp 3.1.3.16 ko:K20074 ko00000,ko01000,ko01009 Bacteria 1V6K5@1239,24JD4@186801,COG0631@1,COG0631@2 NA|NA|NA T Phosphatase PFHLONEA_00777 1128421.JAGA01000002_gene23 5.9e-84 318.2 unclassified Bacteria ko:K07114 ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 Bacteria 2NQ3W@2323,COG2304@1,COG2304@2 NA|NA|NA P von Willebrand factor type A domain PFHLONEA_00778 316274.Haur_4044 2e-23 115.5 Chloroflexia Bacteria 2G9CS@200795,375YC@32061,COG1716@1,COG1716@2 NA|NA|NA T PFAM Forkhead-associated protein PFHLONEA_00781 935948.KE386494_gene372 2.7e-109 402.9 Thermoanaerobacterales yyaL ko:K06888 ko00000 Bacteria 1TPRD@1239,248PD@186801,42FE6@68295,COG1331@1,COG1331@2 NA|NA|NA O COGs COG1331 Highly conserved protein containing a thioredoxin domain PFHLONEA_00782 289376.THEYE_A0436 9.2e-111 406.8 Nitrospirae hisG GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0T5@40117,COG0040@1,COG0040@2 NA|NA|NA F Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity PFHLONEA_00783 443144.GM21_3799 1.2e-140 506.5 Deltaproteobacteria hisD GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23,1.1.1.308 ko:K00013,ko:K15509 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 iYO844.BSU34910 Bacteria 1MUUF@1224,2WJGT@28221,42M3R@68525,COG0141@1,COG0141@2 NA|NA|NA E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine PFHLONEA_00784 443143.GM18_4155 3.2e-146 525.0 Desulfuromonadales murA GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008760,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016765,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 R00660 RC00350 ko00000,ko00001,ko01000,ko01011 Bacteria 1MUH7@1224,2WJ7W@28221,42MJT@68525,43TD6@69541,COG0766@1,COG0766@2 NA|NA|NA M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine PFHLONEA_00785 240015.ACP_2650 3.1e-57 228.8 Acidobacteriia prmC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464 2.1.1.297 ko:K02493 R10806 RC00003,RC03279 ko00000,ko01000,ko03012 Bacteria 2JJCF@204432,3Y4KU@57723,COG2890@1,COG2890@2 NA|NA|NA J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif PFHLONEA_00786 289376.THEYE_A0369 1.8e-126 459.1 Nitrospirae prfA ko:K02835 ko00000,ko03012 Bacteria 3J0F6@40117,COG0216@1,COG0216@2 NA|NA|NA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA PFHLONEA_00787 269799.Gmet_0379 2.7e-86 325.5 Desulfuromonadales prmC ko:K09153 ko00000 Bacteria 1RCB0@1224,2WMZR@28221,42R3I@68525,43U2U@69541,COG3872@1,COG3872@2 NA|NA|NA S Protein of unknown function (DUF1385) PFHLONEA_00788 880073.Calab_1926 1.6e-20 104.8 unclassified Bacteria rpmE GO:0008150,GO:0040007 ko:K02909 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 2NPUV@2323,COG0254@1,COG0254@2 NA|NA|NA J Binds the 23S rRNA PFHLONEA_00789 330214.NIDE0975 1.4e-189 669.1 Nitrospirae rho GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576 ko:K02887,ko:K03628 ko03010,ko03018,map03010,map03018 M00178 br01610,ko00000,ko00001,ko00002,ko03011,ko03019,ko03021 Bacteria 3J0BK@40117,COG1158@1,COG1158@2 NA|NA|NA K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template PFHLONEA_00790 289376.THEYE_A1158 2.6e-26 125.2 Nitrospirae petA 1.10.2.2,1.10.9.1 ko:K00411,ko:K02636,ko:K03886 ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152,M00162 R03817,R08409 RC01002 ko00000,ko00001,ko00002,ko00194,ko01000 iAF987.Gmet_1922 Bacteria 3J0TT@40117,COG0723@1,COG0723@2 NA|NA|NA C Rieske [2Fe-2S] domain PFHLONEA_00791 1123376.AUIU01000013_gene1696 3.7e-65 254.6 Nitrospirae petB GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009512,GO:0009579,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0034357,GO:0040007,GO:0042651,GO:0044424,GO:0044425,GO:0044436,GO:0044459,GO:0044464,GO:0070069,GO:0071944 ko:K00412,ko:K02635,ko:K02637,ko:K03887,ko:K03891,ko:K15879 ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152,M00162 ko00000,ko00001,ko00002,ko00194,ko03029 Bacteria 3J0Q6@40117,COG1290@1,COG1290@2 NA|NA|NA C Cytochrome b/b6/petB PFHLONEA_00792 221109.22777458 2.7e-10 72.0 Oceanobacillus qcrC ko:K00412,ko:K03888 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 ko00000,ko00001,ko00002,ko03029 Bacteria 1TRS8@1239,23J5C@182709,4H9XH@91061,COG1290@1,COG1290@2,COG2010@1,COG2010@2 NA|NA|NA C Cytochrome b(C-terminal)/b6/petD PFHLONEA_00793 589865.DaAHT2_2409 8.4e-76 290.8 Deltaproteobacteria 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 1R13V@1224,2X8CV@28221,43D64@68525,COG1216@1,COG1216@2 NA|NA|NA M PFAM Glycosyl transferase family 2 PFHLONEA_00794 589865.DaAHT2_2410 2.5e-99 369.0 Desulfobacterales 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 R09394 RC03420 ko00000,ko00001,ko01000 Bacteria 1RADC@1224,2MM5N@213118,2WN4I@28221,42RDA@68525,COG0535@1,COG0535@2 NA|NA|NA C Iron-sulfur cluster-binding domain PFHLONEA_00795 439235.Dalk_1816 2.9e-113 415.6 Desulfobacterales Bacteria 1NU8B@1224,2MJ2S@213118,2WIZI@28221,42M88@68525,COG3829@1,COG3829@2 NA|NA|NA T PFAM sigma-54 factor interaction domain-containing protein PFHLONEA_00796 742743.HMPREF9453_02057 1.8e-11 76.3 Negativicutes usp22 Bacteria 1VBRV@1239,4H5NI@909932,COG0589@1,COG0589@2 NA|NA|NA T Belongs to the universal stress protein A family PFHLONEA_00797 243232.MJ_0577 3.6e-11 75.1 Euryarchaeota GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 Archaea 2XV1Y@28890,COG0589@1,arCOG00449@2157 NA|NA|NA T COG0589 Universal stress protein UspA and related nucleotide-binding PFHLONEA_00798 579137.Metvu_1674 1.4e-07 63.2 Euryarchaeota ko:K20989 ko00000,ko02000 2.A.21.6 Archaea 2Y8DK@28890,COG0589@1,arCOG02053@2157 NA|NA|NA T PFAM UspA domain protein PFHLONEA_00801 485913.Krac_9289 1.1e-27 129.0 Bacteria Bacteria COG3316@1,COG3316@2 NA|NA|NA PFHLONEA_00802 243231.GSU2629 1.4e-87 329.7 Desulfuromonadales bioF GO:0003674,GO:0003824,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008710,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.3.1.29,2.3.1.47,6.2.1.14 ko:K00639,ko:K00652,ko:K01906 ko00260,ko00780,ko01100,map00260,map00780,map01100 M00123,M00573,M00577 R00371,R03209,R03210,R10124 RC00004,RC00014,RC00039,RC00394,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 1MVVH@1224,2WIU7@28221,42MM1@68525,43UF0@69541,COG0156@1,COG0156@2 NA|NA|NA H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide PFHLONEA_00803 1232410.KI421421_gene3672 4.7e-50 204.9 Desulfuromonadales bioW 2.3.1.47,6.2.1.14 ko:K00652,ko:K01906 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03209,R03210,R10124 RC00004,RC00014,RC00039,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 1RGQ0@1224,2WNH9@28221,42S6F@68525,43SIA@69541,COG1424@1,COG1424@2 NA|NA|NA H 6-carboxyhexanoate--CoA ligase PFHLONEA_00804 1121413.JMKT01000014_gene2467 1.7e-22 111.7 Desulfovibrionales bioB 2.6.1.62,2.8.1.6 ko:K00833,ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078,R03231 RC00006,RC00441,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 iAF987.Gmet_1582,iJN678.bioB Bacteria 1MVFF@1224,2M83D@213115,2WIMA@28221,42NGR@68525,COG0502@1,COG0502@2 NA|NA|NA H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism PFHLONEA_00805 909663.KI867150_gene2081 6e-24 117.9 Syntrophobacterales slp GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0016020,GO:0019867,GO:0042802 ko:K07285 ko00000 Bacteria 1MZ8C@1224,2MSI1@213462,2WQIC@28221,42TQE@68525,COG3065@1,COG3065@2 NA|NA|NA M Outer membrane lipoprotein Slp family PFHLONEA_00806 316067.Geob_3103 4.1e-73 281.6 Desulfuromonadales Bacteria 1MX1I@1224,2WMNG@28221,42U2R@68525,43UNW@69541,COG3016@1,COG3016@2 NA|NA|NA S Haem-binding uptake, Tiki superfamily, ChaN PFHLONEA_00807 289376.THEYE_A1821 5.3e-33 146.7 Bacteria Bacteria COG4274@1,COG4274@2 NA|NA|NA S GYD domain PFHLONEA_00808 247634.GPB2148_333 5.5e-21 108.6 Gammaproteobacteria Bacteria 1RFDS@1224,1SBRG@1236,COG2067@1,COG2067@2 NA|NA|NA I Protein of unknown function (DUF3187) PFHLONEA_00809 443143.GM18_2042 8.5e-16 91.3 Deltaproteobacteria 3.6.1.27 ko:K19302 ko00550,map00550 R05627 RC00002 ko00000,ko00001,ko01000,ko01011 Bacteria 1QUKE@1224,2WT5A@28221,42XAW@68525,COG0671@1,COG0671@2 NA|NA|NA I PFAM phosphoesterase, PA-phosphatase related PFHLONEA_00811 552811.Dehly_0886 3.1e-92 345.5 Dehalococcoidia mtr GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0010126,GO:0016137,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050627,GO:0050660,GO:0050661,GO:0050662,GO:0051186,GO:0055114,GO:0070402,GO:0071704,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901657 1.8.1.15,1.8.1.4 ko:K00382,ko:K17883 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2G5MR@200795,34DQQ@301297,COG1249@1,COG1249@2 NA|NA|NA C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase PFHLONEA_00812 443144.GM21_0713 2.4e-41 176.0 Desulfuromonadales Bacteria 1NGNC@1224,2EEP1@1,2WWV0@28221,338GU@2,431SC@68525,43VJ3@69541 NA|NA|NA PFHLONEA_00813 868131.MSWAN_0985 1.4e-15 89.0 Euryarchaeota Archaea 2Y22C@28890,COG2329@1,arCOG05403@2157 NA|NA|NA S Chlorite dismutase PFHLONEA_00814 56780.SYN_03122 1.1e-15 89.7 Deltaproteobacteria Bacteria 1N7GY@1224,2E6J8@1,2WRHG@28221,3316B@2,42V6W@68525 NA|NA|NA PFHLONEA_00816 443143.GM18_4030 2.4e-79 302.0 Desulfuromonadales aglR2 ko:K03561,ko:K03562 ko01120,map01120 ko00000,ko02000 1.A.30.2.1,1.A.30.2.2 Bacteria 1PKF8@1224,2WQK7@28221,42TN7@68525,43TGA@69541,COG0811@1,COG0811@2 NA|NA|NA U MotA/TolQ/ExbB proton channel family PFHLONEA_00817 1232410.KI421425_gene1547 1.7e-22 112.1 Desulfuromonadales Bacteria 1NFTI@1224,2EQ5T@1,2WXC2@28221,32ZV0@2,433CK@68525,43VWA@69541 NA|NA|NA PFHLONEA_00818 522772.Dacet_2184 1.3e-17 97.4 Bacteria Bacteria COG4313@1,COG4313@2 NA|NA|NA PFHLONEA_00819 237368.SCABRO_01156 9.5e-47 193.0 Planctomycetes nikR GO:0000976,GO:0000984,GO:0000985,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016043,GO:0016151,GO:0019219,GO:0019222,GO:0022607,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0032991,GO:0032993,GO:0042802,GO:0043167,GO:0043169,GO:0043254,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071840,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 ko:K07722 ko00000,ko03000 Bacteria 2J0XU@203682,COG0864@1,COG0864@2 NA|NA|NA K Transcriptional regulator PFHLONEA_00820 909663.KI867150_gene302 1.5e-53 216.5 Deltaproteobacteria ko:K06076 ko00000,ko02000 1.B.9 Bacteria 1N1F4@1224,2WUUM@28221,42ZP2@68525,COG2067@1,COG2067@2 NA|NA|NA I Putative MetA-pathway of phenol degradation PFHLONEA_00821 515635.Dtur_1767 5.4e-68 264.2 Bacteria cbiM GO:0000041,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015675,GO:0016020,GO:0016021,GO:0030001,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 ko:K02007 ko02010,map02010 M00245,M00246 ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 Bacteria COG0310@1,COG0310@2 NA|NA|NA P cobalt ion transport PFHLONEA_00822 398767.Glov_2810 4.7e-75 288.1 Desulfuromonadales priA GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 ko:K04066 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 1MUUZ@1224,2WJ4G@28221,42MNH@68525,43U9D@69541,COG1198@1,COG1198@2 NA|NA|NA L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA PFHLONEA_00823 909663.KI867150_gene149 1e-178 633.3 Syntrophobacterales emrY GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0033554,GO:0042221,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071944 ko:K03446,ko:K07786 ko02020,map02020 M00701 ko00000,ko00001,ko00002,ko02000 2.A.1.3,2.A.1.3.36 Bacteria 1RGPN@1224,2MQAD@213462,2X6ZQ@28221,43BMI@68525,COG0477@1,COG0477@2 NA|NA|NA EGP Sugar (and other) transporter PFHLONEA_00826 443143.GM18_0979 9.2e-17 93.2 delta/epsilon subdivisions XK27_09090 ko:K09153 ko00000 Bacteria 1NF5Z@1224,42VNI@68525,COG2456@1,COG2456@2 NA|NA|NA S Uncharacterized conserved protein (DUF2304) PFHLONEA_00827 645991.Sgly_1880 1.1e-63 250.0 Peptococcaceae ycbB ko:K00786 ko00000,ko01000 Bacteria 1TS11@1239,24BQ6@186801,261RR@186807,COG1216@1,COG1216@2 NA|NA|NA S glycosyl transferase family 2 PFHLONEA_00828 1232410.KI421412_gene226 3.7e-81 308.5 Desulfuromonadales wbbL_2 ko:K07011 ko00000 Bacteria 1R6SJ@1224,2WN5X@28221,42R6J@68525,43TWV@69541,COG1216@1,COG1216@2 NA|NA|NA M Glycosyl transferase family group 2 PFHLONEA_00829 330214.NIDE3048 3e-27 128.3 Nitrospirae ko:K09928 ko00000 Bacteria 3J1DC@40117,COG3216@1,COG3216@2 NA|NA|NA S Uncharacterized protein conserved in bacteria (DUF2062) PFHLONEA_00830 269799.Gmet_3213 7.4e-69 267.7 Desulfuromonadales thiL GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009030,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009229,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0035639,GO:0036094,GO:0042357,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 iSFV_1184.SFV_0382,iYO844.BSU05900 Bacteria 1MU9X@1224,2WNGE@28221,42MYJ@68525,43UHS@69541,COG0611@1,COG0611@2 NA|NA|NA H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 PFHLONEA_00831 330214.NIDE3046 3.7e-210 737.6 Nitrospirae lon 3.4.21.53 ko:K01338 ko04112,map04112 ko00000,ko00001,ko01000,ko01002 Bacteria 3J0DQ@40117,COG0466@1,COG0466@2 NA|NA|NA O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner PFHLONEA_00832 1499967.BAYZ01000073_gene2007 4.2e-132 478.4 unclassified Bacteria nnrD GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0052855,GO:0052856,GO:0052857 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 ko00000,ko01000 Bacteria 2NNR2@2323,COG0062@1,COG0062@2,COG0063@1,COG0063@2 NA|NA|NA G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration PFHLONEA_00833 1167006.UWK_00505 1.8e-35 155.6 Desulfobacterales Bacteria 1QUKQ@1224,2MK07@213118,2WQQ5@28221,42TPD@68525,COG0517@1,COG0517@2 NA|NA|NA S PFAM CBS domain PFHLONEA_00834 1304284.L21TH_1555 3.4e-35 154.8 Clostridiaceae yjeE 2.7.1.221 ko:K06925,ko:K07102,ko:K07452 ko00520,ko01100,map00520,map01100 R08968,R11024 RC00002,RC00078 ko00000,ko00001,ko01000,ko02048,ko03016 Bacteria 1V6CV@1239,24MSS@186801,36IUF@31979,COG0802@1,COG0802@2 NA|NA|NA S Threonylcarbamoyl adenosine biosynthesis protein TsaE PFHLONEA_00835 338963.Pcar_2327 1.1e-76 293.5 Desulfuromonadales nadK GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 R00104 RC00002,RC00078 ko00000,ko00001,ko01000 iEcSMS35_1347.EcSMS35_2767,iHN637.CLJU_RS05480,iLJ478.TM1733,iSB619.SA_RS04895 Bacteria 1MUBC@1224,2WKMR@28221,42MP8@68525,43SZE@69541,COG0061@1,COG0061@2 NA|NA|NA F Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP PFHLONEA_00836 671143.DAMO_2419 5.9e-66 257.7 unclassified Bacteria dpo 3.2.2.27 ko:K21929 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 2NP99@2323,COG1573@1,COG1573@2 NA|NA|NA L Uracil DNA glycosylase superfamily PFHLONEA_00837 1499967.BAYZ01000065_gene6091 2e-275 955.3 unclassified Bacteria mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 ko:K03555 ko03430,map03430 ko00000,ko00001,ko03400 Bacteria 2NNN6@2323,COG0249@1,COG0249@2 NA|NA|NA L that it carries out the mismatch recognition step. This protein has a weak ATPase activity PFHLONEA_00838 439235.Dalk_4326 2.9e-88 332.4 Desulfobacterales Bacteria 1R7HC@1224,2MJWK@213118,2WN4S@28221,42QMQ@68525,COG2199@1,COG3706@2 NA|NA|NA T diguanylate cyclase PFHLONEA_00839 243231.GSU0668 5.6e-37 160.6 Desulfuromonadales rplI GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02939 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1RD0R@1224,2WPZQ@28221,42SCQ@68525,43V2Z@69541,COG0359@1,COG0359@2 NA|NA|NA J Binds to the 23S rRNA PFHLONEA_00840 243231.GSU0998 1.6e-146 526.2 Desulfuromonadales dnaB 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 ko00000,ko00001,ko01000,ko03032 Bacteria 1MUG9@1224,2WJCA@28221,42M7X@68525,43SXC@69541,COG0305@1,COG0305@2 NA|NA|NA L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins PFHLONEA_00841 552811.Dehly_0349 2.5e-67 262.3 Dehalococcoidia amrA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0032886,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0065007 ko:K06990,ko:K09141 ko00000,ko04812 Bacteria 2G6V0@200795,34CZ7@301297,COG1355@1,COG1355@2,COG2078@1,COG2078@2 NA|NA|NA S Memo-like protein PFHLONEA_00842 289376.THEYE_A1305 3.5e-36 157.9 Nitrospirae Bacteria 3J19Z@40117,COG1651@1,COG1651@2 NA|NA|NA O DSBA-like thioredoxin domain PFHLONEA_00844 289376.THEYE_A0029 2e-136 491.9 Nitrospirae acsA 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 3J0BJ@40117,COG0365@1,COG0365@2 NA|NA|NA I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA PFHLONEA_00845 398767.Glov_2384 7.1e-15 87.4 Proteobacteria Bacteria 1RK55@1224,2ATWF@1,31JFP@2 NA|NA|NA PFHLONEA_00847 1304865.JAGF01000001_gene965 3.3e-14 84.7 Actinobacteria Bacteria 2EG8Z@1,2I8BH@201174,33A0S@2 NA|NA|NA PFHLONEA_00848 316067.Geob_2114 1.8e-76 292.7 Deltaproteobacteria gt2F 2.4.1.175,2.4.1.226 ko:K13500 ko00532,ko01100,map00532,map01100 R04603,R05931,R05932,R05933,R05934,R07336 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003 GT2 Bacteria 1R6YR@1224,2WK5K@28221,43CDN@68525,COG1215@1,COG1215@2 NA|NA|NA M N-terminal domain of galactosyltransferase PFHLONEA_00849 330214.NIDE3950 1.5e-86 326.2 Nitrospirae lipA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 R07767,R07768 RC01978 ko00000,ko00001,ko01000 Bacteria 3J0IY@40117,COG0320@1,COG0320@2 NA|NA|NA H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives PFHLONEA_00850 1382306.JNIM01000001_gene3450 1.2e-170 606.3 Chloroflexi lon 3.4.21.53 ko:K01338 ko04112,map04112 ko00000,ko00001,ko01000,ko01002 Bacteria 2G5TZ@200795,COG0466@1,COG0466@2 NA|NA|NA O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner PFHLONEA_00851 269799.Gmet_0366 1.6e-112 412.9 Desulfuromonadales rnj GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004527,GO:0004532,GO:0004534,GO:0004540,GO:0005488,GO:0005515,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008409,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042802,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0090503,GO:0140098,GO:1901360 ko:K12574 ko03018,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 1MUGV@1224,2WIQ9@28221,42M65@68525,43U97@69541,COG0595@1,COG0595@2 NA|NA|NA J An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay PFHLONEA_00854 118005.AWNK01000012_gene23 3e-13 80.5 Bacteria Bacteria 2ESEE@1,33JZ4@2 NA|NA|NA S N-terminal domain of cytochrome oxidase-cbb3, FixP PFHLONEA_00855 522772.Dacet_1539 2.8e-91 342.0 Deferribacteres ccoO 1.9.3.1 ko:K00405,ko:K15862 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 ko00000,ko00001,ko00002,ko01000 3.D.4.3 iIT341.HP0145 Bacteria 2GF4M@200930,COG2010@1,COG2010@2,COG2993@1,COG2993@2 NA|NA|NA C PFAM cytochrome C oxidase mono-heme subunit FixO PFHLONEA_00856 768670.Calni_0818 1.8e-219 768.5 Deferribacteres ccoN GO:0003674,GO:0003824,GO:0004129,GO:0005215,GO:0005488,GO:0005506,GO:0005507,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008144,GO:0008150,GO:0008152,GO:0008324,GO:0009055,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015002,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0015975,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016310,GO:0016491,GO:0016675,GO:0016676,GO:0016705,GO:0017144,GO:0019411,GO:0019637,GO:0019646,GO:0019693,GO:0019825,GO:0020037,GO:0022857,GO:0022890,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0034641,GO:0036094,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045154,GO:0045333,GO:0046034,GO:0046483,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0055114,GO:0070069,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:1901135,GO:1901360,GO:1901363,GO:1901564,GO:1902600 1.9.3.1 ko:K00404,ko:K15862 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 ko00000,ko00001,ko00002,ko01000 3.D.4.3 iIT341.HP0144 Bacteria 2GFA9@200930,COG3278@1,COG3278@2 NA|NA|NA C Belongs to the heme-copper respiratory oxidase family PFHLONEA_00857 589865.DaAHT2_0174 2.3e-26 125.2 Desulfobacterales ko:K13771 ko05132,map05132 ko00000,ko00001,ko03000 Bacteria 1MZ1C@1224,2MM91@213118,2WPVC@28221,42SPF@68525,COG1959@1,COG1959@2 NA|NA|NA K TIGRFAM transcriptional regulator, Rrf2 family PFHLONEA_00858 1121918.ARWE01000001_gene2503 5e-34 150.2 Deltaproteobacteria ahpC GO:0003674,GO:0003824,GO:0004601,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009321,GO:0009605,GO:0009636,GO:0009970,GO:0009987,GO:0009991,GO:0010033,GO:0016209,GO:0016491,GO:0016667,GO:0016671,GO:0016684,GO:0019725,GO:0030003,GO:0031667,GO:0031668,GO:0031669,GO:0032843,GO:0032991,GO:0033194,GO:0033195,GO:0033212,GO:0033214,GO:0033554,GO:0042221,GO:0042592,GO:0042594,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071496,GO:0097237,GO:0098754,GO:0098771,GO:0098869,GO:1901700,GO:1902494,GO:1990204,GO:1990748 1.11.1.15 ko:K03386 ko04214,map04214 ko00000,ko00001,ko01000,ko04147 Bacteria 1MYZG@1224,2WP3M@28221,42SNG@68525,COG0450@1,COG0450@2 NA|NA|NA O PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen PFHLONEA_00859 589865.DaAHT2_2091 8.1e-13 79.0 Desulfobacterales ahpC GO:0003674,GO:0003824,GO:0004601,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009321,GO:0009605,GO:0009636,GO:0009970,GO:0009987,GO:0009991,GO:0010033,GO:0016209,GO:0016491,GO:0016667,GO:0016671,GO:0016684,GO:0019725,GO:0030003,GO:0031667,GO:0031668,GO:0031669,GO:0032843,GO:0032991,GO:0033194,GO:0033195,GO:0033212,GO:0033214,GO:0033554,GO:0042221,GO:0042592,GO:0042594,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071496,GO:0097237,GO:0098754,GO:0098771,GO:0098869,GO:1901700,GO:1902494,GO:1990204,GO:1990748 1.11.1.15 ko:K03386 ko04214,map04214 ko00000,ko00001,ko01000,ko04147 Bacteria 1MWPY@1224,2MJSH@213118,2WNIG@28221,42MAJ@68525,COG0450@1,COG0450@2 NA|NA|NA O AhpC/TSA family PFHLONEA_00860 768671.ThimaDRAFT_0814 2e-19 103.2 Gammaproteobacteria Bacteria 1MUWD@1224,1RZ0Z@1236,COG0348@1,COG0348@2 NA|NA|NA C 4Fe-4S binding domain PFHLONEA_00862 596151.DesfrDRAFT_3640 4e-113 415.2 Desulfovibrionales 2.7.13.3 ko:K07709 ko02020,map02020 M00499 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 1RCM9@1224,2M9ND@213115,2X1VE@28221,439Y6@68525,COG4191@1,COG4191@2 NA|NA|NA T histidine kinase HAMP region domain protein PFHLONEA_00863 637389.Acaty_c2637 3.6e-62 245.7 Acidithiobacillales ygfZ 3.1.21.3 ko:K01153,ko:K02498 ko00000,ko01000,ko02048 Bacteria 1NX21@1224,1TE02@1236,2NDG3@225057,COG3071@1,COG3071@2 NA|NA|NA H Type II secretion system (T2SS), protein E, N-terminal domain PFHLONEA_00864 637390.AFOH01000110_gene2869 6.7e-72 278.5 Acidithiobacillales Bacteria 1NR5U@1224,1T8UM@1236,2BH64@1,2NDG0@225057,33QKM@2 NA|NA|NA S Type II secretion system (T2SS), protein E, N-terminal domain PFHLONEA_00865 1382356.JQMP01000003_gene1984 9.2e-10 68.9 Thermomicrobia tatA ko:K03116 ko03060,ko03070,map03060,map03070 M00336 ko00000,ko00001,ko00002,ko02044 2.A.64 Bacteria 27ZC2@189775,2GBFR@200795,COG1826@1,COG1826@2 NA|NA|NA U mttA/Hcf106 family PFHLONEA_00866 1123376.AUIU01000019_gene1273 2.9e-11 75.1 Nitrospirae Bacteria 3J1A7@40117,COG0589@1,COG0589@2 NA|NA|NA T Belongs to the universal stress protein A family PFHLONEA_00867 192952.MM_1452 5.6e-25 121.7 Euryarchaeota Archaea 2Y8D8@28890,COG0589@1,arCOG00449@2157 NA|NA|NA T Universal stress protein family PFHLONEA_00868 667014.Thein_2066 2.5e-43 182.6 Thermodesulfobacteria MA20_19830 Bacteria 2AFUA@1,2GIA0@200940,315WQ@2 NA|NA|NA S Putative transmembrane protein (Alph_Pro_TM) PFHLONEA_00869 1123371.ATXH01000001_gene1241 9e-114 416.8 Thermodesulfobacteria MA20_19835 ko:K07090 ko00000 Bacteria 2GI6P@200940,COG0730@1,COG0730@2 NA|NA|NA S Sulfite exporter TauE/SafE PFHLONEA_00871 589865.DaAHT2_1598 4e-38 164.9 Desulfobacterales Bacteria 1N4MT@1224,2C5Z2@1,2MKYF@213118,2WQZM@28221,32U5Z@2,42TX0@68525 NA|NA|NA S Domain of unknown function (DUF3786) PFHLONEA_00872 316067.Geob_3101 6.7e-50 203.8 Desulfuromonadales greB GO:0006139,GO:0006351,GO:0006352,GO:0006354,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010604,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031437,GO:0031439,GO:0032774,GO:0032784,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903311,GO:1903313,GO:1903506,GO:2000112,GO:2001141 ko:K04760 ko00000,ko03021 Bacteria 1RAP0@1224,2WPPH@28221,42SDH@68525,43V7T@69541,COG0782@1,COG0782@2 NA|NA|NA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length PFHLONEA_00873 330214.NIDE0829 2.9e-50 206.1 Nitrospirae Bacteria 3J16W@40117,COG5459@1,COG5459@2 NA|NA|NA J Mitochondrial small ribosomal subunit Rsm22 PFHLONEA_00874 269799.Gmet_0588 3e-100 372.9 Desulfuromonadales Bacteria 1NFQW@1224,2WKWA@28221,42MT2@68525,43TXB@69541,COG0457@1,COG0457@2 NA|NA|NA S PFAM Tetratricopeptide TPR_1 repeat-containing protein PFHLONEA_00875 909663.KI867150_gene389 4e-104 384.4 Syntrophobacterales Bacteria 1R50T@1224,2MQ8C@213462,2WK88@28221,42P74@68525,COG1216@1,COG1216@2 NA|NA|NA S Glycosyl transferase family 2 PFHLONEA_00876 485915.Dret_0701 2.6e-28 131.7 Desulfovibrionales nla28 ko:K07713,ko:K07714 ko02020,map02020 M00499,M00500 ko00000,ko00001,ko00002,ko02022 Bacteria 1MU0N@1224,2M8TB@213115,2WJKZ@28221,42M03@68525,COG2204@1,COG2204@2 NA|NA|NA T Sigma-54 factor interaction domain-containing protein PFHLONEA_00877 338963.Pcar_0005 1.9e-24 118.6 Desulfuromonadales gyrA 5.99.1.3 ko:K02469 ko00000,ko01000,ko03032,ko03400 Bacteria 1MUGG@1224,2WJBC@28221,42KZ9@68525,43SC5@69541,COG0188@1,COG0188@2 NA|NA|NA L DNA Topoisomerase IV PFHLONEA_00878 1242864.D187_001792 1.1e-06 60.8 Deltaproteobacteria Bacteria 1MX82@1224,2WR3B@28221,42TQ9@68525,COG0457@1,COG0457@2,COG1729@1,COG1729@2 NA|NA|NA S tetratricopeptide repeat PFHLONEA_00879 289376.THEYE_A0018 3.1e-157 561.6 Nitrospirae serS GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004828,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006434,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009059,GO:0009069,GO:0009070,GO:0009987,GO:0010467,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iAF987.Gmet_3528,iSDY_1059.SDY_2368 Bacteria 3J0EP@40117,COG0172@1,COG0172@2 NA|NA|NA J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) PFHLONEA_00882 316067.Geob_1193 6.2e-22 110.9 Desulfuromonadales ko:K07465 ko00000 Bacteria 1N5MU@1224,2WR2C@28221,42TQ6@68525,43VB1@69541,COG4765@1,COG4765@2 NA|NA|NA S Uncharacterized protein conserved in bacteria (DUF2155) PFHLONEA_00884 289376.THEYE_A1388 1.9e-43 182.2 Nitrospirae tadA GO:0002097,GO:0002100,GO:0006139,GO:0006382,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016553,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 3.5.4.33 ko:K11991 R10223 RC00477 ko00000,ko01000,ko03016 Bacteria 3J0PE@40117,COG0590@1,COG0590@2 NA|NA|NA FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) PFHLONEA_00888 1116472.MGMO_14c00060 8.7e-230 803.1 Methylococcales kdpA GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0030955,GO:0031004,GO:0031224,GO:0031226,GO:0031420,GO:0032991,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090533,GO:0090662,GO:0098533,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.12 ko:K01546 ko02020,map02020 ko00000,ko00001,ko01000 3.A.3.7 iAPECO1_1312.APECO1_1369,iECUMN_1333.ECUMN_0780,iYL1228.KPN_00717 Bacteria 1MV1K@1224,1RQZU@1236,1XE95@135618,COG2060@1,COG2060@2 NA|NA|NA P Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane PFHLONEA_00890 76114.ebA6732 3e-53 214.9 Betaproteobacteria Bacteria 1R3EE@1224,2DP2V@1,2VUJY@28216,330AH@2 NA|NA|NA S Protein of unknown function (DUF3455) PFHLONEA_00891 398527.Bphyt_4937 9.5e-34 149.4 Burkholderiaceae 1.14.14.28 ko:K20938 ko00000,ko01000 Bacteria 1K98I@119060,1N1AN@1224,2W2Q1@28216,COG1359@1,COG1359@2 NA|NA|NA S (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity PFHLONEA_00892 1158756.AQXQ01000010_gene2183 2.8e-36 159.1 Chromatiales yjbJ Bacteria 1MZ4X@1224,1S8R3@1236,1WZ62@135613,COG0741@1,COG0741@2 NA|NA|NA M Transglycosylase SLT domain PFHLONEA_00895 696281.Desru_1517 2e-54 219.2 Peptococcaceae Bacteria 1VW4M@1239,250UV@186801,265AM@186807,COG5012@1,COG5012@2 NA|NA|NA S PFAM B12 binding domain PFHLONEA_00896 204669.Acid345_4724 7.4e-10 69.7 Acidobacteriia Bacteria 2EA3B@1,2JJZE@204432,3348D@2,3Y5J1@57723 NA|NA|NA PFHLONEA_00897 909663.KI867150_gene313 2.6e-84 318.5 Syntrophobacterales Bacteria 1MU7F@1224,2MRS3@213462,2WP4W@28221,42RV4@68525,COG1801@1,COG1801@2 NA|NA|NA S Protein of unknown function DUF72 PFHLONEA_00898 370438.PTH_2609 6.9e-49 200.3 Peptococcaceae moaC GO:0002682,GO:0002683,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009605,GO:0009607,GO:0009987,GO:0016043,GO:0016829,GO:0016849,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0022607,GO:0031347,GO:0031348,GO:0034214,GO:0035821,GO:0040007,GO:0042802,GO:0043170,GO:0043207,GO:0043545,GO:0043933,GO:0044003,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044413,GO:0044414,GO:0044419,GO:0045088,GO:0045824,GO:0046483,GO:0048519,GO:0048583,GO:0048585,GO:0050776,GO:0050777,GO:0050789,GO:0050896,GO:0051186,GO:0051188,GO:0051189,GO:0051259,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0051832,GO:0051833,GO:0052031,GO:0052037,GO:0052167,GO:0052170,GO:0052173,GO:0052200,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0061799,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0075136,GO:0080134,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 R11372 RC03425 ko00000,ko00001,ko01000 Bacteria 1V3J4@1239,24H9F@186801,261ZC@186807,COG0315@1,COG0315@2 NA|NA|NA H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) PFHLONEA_00901 1094980.Mpsy_1766 1.8e-08 65.1 Methanomicrobia porD 1.2.7.1 ko:K00171 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 Archaea 2N9YE@224756,2Y02N@28890,COG1144@1,arCOG01605@2157 NA|NA|NA C TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit PFHLONEA_00902 1041930.Mtc_0840 3e-48 198.4 Methanomicrobia porC 1.2.7.1,1.2.7.7 ko:K00172,ko:K00189 ko00010,ko00020,ko00280,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R07160,R08034,R08566,R08567 RC00004,RC00250,RC02742,RC02833,RC02856 br01601,ko00000,ko00001,ko00002,ko01000 Archaea 2N9J1@224756,2XVFR@28890,COG1014@1,arCOG01603@2157 NA|NA|NA C TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit PFHLONEA_00903 656519.Halsa_0746 4.5e-15 87.4 Halanaerobiales Bacteria 1TRMW@1239,24BQA@186801,3WB1P@53433,COG1414@1,COG1414@2 NA|NA|NA K helix_turn_helix isocitrate lyase regulation PFHLONEA_00907 314345.SPV1_12495 1.5e-72 280.0 Proteobacteria tqsA GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0009372,GO:0009987,GO:0015562,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0044764,GO:0051179,GO:0051234,GO:0051704,GO:0055085,GO:0071944 ko:K11744 ko00000 Bacteria 1MXXU@1224,COG0628@1,COG0628@2 NA|NA|NA T permease PFHLONEA_00908 243231.GSU2782 1.1e-43 182.6 Desulfuromonadales acrB ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 Bacteria 1MU48@1224,2WJ8D@28221,42MF6@68525,43S5E@69541,COG0841@1,COG0841@2 NA|NA|NA V AcrB/AcrD/AcrF family PFHLONEA_00909 443143.GM18_0717 1.9e-175 622.5 Deltaproteobacteria lnt ko:K03820 ko00000,ko01000 GT2 Bacteria 1MUBU@1224,2WIUD@28221,42MPS@68525,COG0815@1,COG0815@2 NA|NA|NA M Transfers the fatty acyl group on membrane lipoproteins PFHLONEA_00910 929556.Solca_0756 1.5e-30 139.0 Sphingobacteriia Bacteria 1IXRT@117747,4NV45@976,COG3795@1,COG3795@2 NA|NA|NA S YCII-related domain PFHLONEA_00911 439235.Dalk_3212 1.3e-14 87.0 Desulfobacterales Bacteria 1QU02@1224,2MNB3@213118,2X71N@28221,43BQJ@68525,COG2867@1,COG2867@2 NA|NA|NA I PFAM lipid-binding START domain protein PFHLONEA_00915 1123514.KB905902_gene191 5.4e-11 74.3 Thiotrichales trxC 1.8.1.8 ko:K03672 ko00000,ko01000,ko03110 Bacteria 1RHUA@1224,1S64W@1236,4610B@72273,COG3118@1,COG3118@2 NA|NA|NA O Thioredoxin PFHLONEA_00916 644282.Deba_0117 9.2e-165 586.6 Deltaproteobacteria pgk 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1R5QA@1224,2WMKU@28221,42MED@68525,COG0126@1,COG0126@2 NA|NA|NA G Phosphoglycerate kinase PFHLONEA_00918 269799.Gmet_0728 3.8e-14 85.1 Desulfuromonadales Bacteria 1P22J@1224,2WWBW@28221,4310H@68525,43VHQ@69541,COG0457@1,COG0457@2 NA|NA|NA S Tetratricopeptide repeat PFHLONEA_00919 595460.RRSWK_00838 1.9e-100 372.9 Planctomycetes metB 2.5.1.48,4.4.1.8 ko:K01739,ko:K01760 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04941,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00382,RC00420,RC00488,RC00710,RC01245,RC02303,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 Bacteria 2IYGK@203682,COG0626@1,COG0626@2 NA|NA|NA E Cys Met metabolism PFHLONEA_00920 237368.SCABRO_01577 2e-175 622.1 Planctomycetes thrC 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 Bacteria 2IXKE@203682,COG0498@1,COG0498@2 NA|NA|NA E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine PFHLONEA_00922 696281.Desru_2162 2.5e-48 198.7 Peptococcaceae ko:K07090 ko00000 Bacteria 1TST0@1239,24B4S@186801,260G8@186807,COG0730@1,COG0730@2 NA|NA|NA S membrane transporter protein PFHLONEA_00923 1294142.CINTURNW_3524 9.6e-28 131.3 Clostridiaceae Bacteria 1UXZ3@1239,24T5J@186801,36N3W@31979,COG2020@1,COG2020@2 NA|NA|NA O Isoprenylcysteine carboxyl methyltransferase (ICMT) family PFHLONEA_00925 671065.MetMK1DRAFT_00003750 6.8e-21 109.8 Crenarchaeota ko:K03521,ko:K03522 ko00000,ko04147 Archaea 2XSRS@28889,COG2025@1,arCOG00448@2157 NA|NA|NA C Electron transfer flavoprotein PFHLONEA_00926 44251.PDUR_14470 6.5e-15 88.2 Paenibacillaceae 6.3.1.20 ko:K03800 ko00785,ko01100,map00785,map01100 R07770,R07771,R11143 RC00043,RC00070,RC00090,RC00992,RC02896 ko00000,ko00001,ko01000 Bacteria 1UZ1X@1239,26VJ6@186822,4I6YM@91061,COG1852@1,COG1852@2 NA|NA|NA S Protein of unknown function DUF116 PFHLONEA_00927 1123376.AUIU01000015_gene491 2.6e-32 145.6 Bacteria Bacteria COG0500@1,COG2226@2 NA|NA|NA Q methyltransferase PFHLONEA_00928 1162668.LFE_1700 8.2e-34 149.8 Nitrospirae nuoA 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 3J0MS@40117,COG0838@1,COG0838@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient PFHLONEA_00929 768670.Calni_0313 8.9e-57 226.5 Deferribacteres nuoB GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 iAF987.Gmet_3354 Bacteria 2GEU3@200930,COG0377@1,COG0377@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient PFHLONEA_00930 269799.Gmet_0294 1.1e-219 769.2 Desulfuromonadales nrfA 1.7.2.2 ko:K03385 ko00910,ko01120,ko05132,map00910,map01120,map05132 M00530 R05712 RC00176 ko00000,ko00001,ko00002,ko01000 Bacteria 1MVJT@1224,2WIJ1@28221,42MPU@68525,43TBA@69541,COG3303@1,COG3303@2 NA|NA|NA C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process PFHLONEA_00931 269799.Gmet_0295 2.2e-52 211.8 Desulfuromonadales nrfH GO:0005575,GO:0006807,GO:0008150,GO:0008152,GO:0016020,GO:0016021,GO:0031224,GO:0044425 ko:K15876 ko00910,ko01120,map00910,map01120 M00530 R05712 RC00176 ko00000,ko00001,ko00002 Bacteria 1RI0B@1224,2WNR2@28221,42T5J@68525,43UWM@69541,COG3005@1,COG3005@2 NA|NA|NA C NapC/NirT cytochrome c family, N-terminal region PFHLONEA_00932 589865.DaAHT2_0550 2.9e-114 418.7 Desulfobacterales 1.2.7.12 ko:K11261 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00567 R03015,R08060,R11743 RC00197,RC00323 ko00000,ko00001,ko00002,ko01000 Bacteria 1QUKM@1224,2MITK@213118,2X75Q@28221,42NTF@68525,COG0303@1,COG0303@2 NA|NA|NA H Probable molybdopterin binding domain PFHLONEA_00933 443143.GM18_4465 1e-23 116.7 Deltaproteobacteria ko:K02019,ko:K05772 ko02010,map02010 M00186 ko00000,ko00001,ko00002,ko02000,ko03000 3.A.1.6.2,3.A.1.6.4 Bacteria 1MZ31@1224,2WRTB@28221,42NA0@68525,COG2005@1,COG2005@2 NA|NA|NA S Bacterial regulatory helix-turn-helix protein, lysR family PFHLONEA_00934 1499967.BAYZ01000027_gene1786 6.8e-21 106.7 unclassified Bacteria pilR ko:K02667 ko02020,map02020 M00501 ko00000,ko00001,ko00002,ko02022,ko02035 Bacteria 2NNWS@2323,COG2204@1,COG2204@2 NA|NA|NA T Two component, sigma54 specific, transcriptional regulator, Fis family PFHLONEA_00935 574087.Acear_0505 3.6e-181 641.3 Halanaerobiales ubiD GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008694,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 iECO111_1330.ECO111_4669,iIT341.HP0396 Bacteria 1TQ6V@1239,248WY@186801,3WB84@53433,COG0043@1,COG0043@2 NA|NA|NA H Belongs to the UbiD family PFHLONEA_00936 266117.Rxyl_0959 2e-11 75.5 Rubrobacteria cofC GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0043814,GO:0044237,GO:0044249,GO:0051186,GO:0051188,GO:0070568 2.7.7.68 ko:K14941 ko00680,ko01120,map00680,map01120 M00378 R09397 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 2HNVD@201174,4CQ43@84995,COG1920@1,COG1920@2 NA|NA|NA S Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor PFHLONEA_00938 243231.GSU2023 1.2e-21 109.4 Desulfuromonadales Bacteria 1NG1T@1224,2WS9A@28221,42VP4@68525,43V7Y@69541,COG2018@1,COG2018@2 NA|NA|NA S Roadblock/LC7 domain PFHLONEA_00939 1121423.JONT01000007_gene589 2.3e-46 191.8 Peptococcaceae aroQ GO:0003674,GO:0003824,GO:0003855,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:1901576 3.4.13.9,4.2.1.10 ko:K01271,ko:K03785,ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000,ko01002 iIT341.HP1038,iJN746.PP_0560,iLJ478.TM0349 Bacteria 1V6E8@1239,24JBK@186801,2621A@186807,COG0757@1,COG0757@2 NA|NA|NA E Catalyzes a trans-dehydration via an enolate intermediate PFHLONEA_00940 997346.HMPREF9374_0272 3.5e-77 295.4 Thermoactinomycetaceae yqhT 3.4.11.9,3.4.13.9 ko:K01262,ko:K01271 ko00000,ko01000,ko01002 Bacteria 1TQ44@1239,27BJY@186824,4HAT7@91061,COG0006@1,COG0006@2 NA|NA|NA E Creatinase/Prolidase N-terminal domain PFHLONEA_00941 1162668.LFE_0957 4.1e-69 267.7 Nitrospirae efp GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006448,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0072344,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112,GO:2000113,GO:2001124,GO:2001125 ko:K02356 ko00000,ko03012 Bacteria 3J0JC@40117,COG0231@1,COG0231@2 NA|NA|NA J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase PFHLONEA_00942 913865.DOT_5441 8.5e-36 156.8 Peptococcaceae oadA 2.1.3.1,2.3.1.12,4.1.1.3,6.4.1.1,6.4.1.7 ko:K00627,ko:K01571,ko:K01960,ko:K02160,ko:K03416,ko:K20140 ko00010,ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko01230,map00010,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212,map01230 M00082,M00173,M00307,M00376,M00620 R00209,R00217,R00344,R00353,R00742,R00930,R02569 RC00004,RC00040,RC00097,RC00367,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000,ko02000 3.B.1.1.1 iJN746.PP_5346 Bacteria 1VT8P@1239,247NZ@186801,260JY@186807,COG0511@1,COG0511@2,COG5016@1,COG5016@2 NA|NA|NA CI Acetyl-CoA carboxylase, biotin carboxyl carrier protein PFHLONEA_00943 330214.NIDE2469 1.5e-170 605.9 Nitrospirae accC 6.3.4.14,6.4.1.1,6.4.1.2 ko:K01959,ko:K01961 ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko01230,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212,map01230 M00082,M00173,M00376,M00620 R00344,R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0AJ@40117,COG0439@1,COG0439@2 NA|NA|NA I Biotin carboxylase C-terminal domain PFHLONEA_00944 330214.NIDE2470 1.8e-43 182.6 Nitrospirae thiE GO:0000287,GO:0003674,GO:0003824,GO:0004789,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3,2.7.1.49,2.7.4.7 ko:K00788,ko:K14153 ko00730,ko01100,map00730,map01100 M00127 R03223,R03471,R04509,R10712 RC00002,RC00017,RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 iE2348C_1286.E2348C_4300,iSSON_1240.SSON_4166 Bacteria 3J0ND@40117,COG0352@1,COG0352@2 NA|NA|NA H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) PFHLONEA_00946 1123376.AUIU01000019_gene1255 2.6e-37 161.4 Bacteria ppdK 2.7.9.1,2.7.9.2 ko:K01006,ko:K01007 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173,M00374 R00199,R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 Bacteria COG0574@1,COG0574@2,COG3848@1,COG3848@2 NA|NA|NA GT kinase activity PFHLONEA_00947 243231.GSU2724 1.2e-109 404.1 Bacteria Bacteria 2DVSV@1,33X1K@2 NA|NA|NA PFHLONEA_00948 269799.Gmet_1680 1.2e-18 99.0 Deltaproteobacteria Bacteria 1NBYG@1224,2CFNS@1,2WR8A@28221,331AJ@2,42VZ5@68525 NA|NA|NA PFHLONEA_00949 269799.Gmet_0767 3.4e-64 251.5 Desulfuromonadales yjgR ko:K06915,ko:K19172 ko00000,ko02048 Bacteria 1MU59@1224,2WKVP@28221,42MTV@68525,43S8J@69541,COG0433@1,COG0433@2 NA|NA|NA S Bacterial protein of unknown function (DUF853) PFHLONEA_00950 269799.Gmet_3488 1.4e-121 443.0 Deltaproteobacteria Bacteria 1PWZS@1224,2DBVK@1,2WXWI@28221,2ZBBH@2,432W2@68525 NA|NA|NA S Ion channel PFHLONEA_00952 926560.KE387023_gene2277 8.6e-23 112.5 Deinococcus-Thermus ko:K07322 ko00000 Bacteria 1WKCP@1297,COG4309@1,COG4309@2 NA|NA|NA S Uncharacterized conserved protein (DUF2249) PFHLONEA_00954 1049564.TevJSym_ao00390 6.5e-23 113.6 unclassified Gammaproteobacteria fjo27 Bacteria 1JBHN@118884,1NGE7@1224,1SGEP@1236,COG5652@1,COG5652@2 NA|NA|NA S PFAM VanZ PFHLONEA_00955 56780.SYN_00285 7.7e-76 290.8 Deltaproteobacteria ko:K02005 ko00000 Bacteria 1PZST@1224,2WMVJ@28221,42R2S@68525,COG0845@1,COG0845@2 NA|NA|NA M TIGRFAM efflux transporter, RND family, MFP subunit PFHLONEA_00956 335543.Sfum_1482 3.8e-34 152.1 Syntrophobacterales ko:K03453 ko00000 2.A.28 Bacteria 1Q36S@1224,2MSBZ@213462,2WSXX@28221,42WV7@68525,COG0385@1,COG0385@2 NA|NA|NA S PFAM Bile acid sodium symporter PFHLONEA_00960 589865.DaAHT2_0101 1.4e-85 322.8 Desulfobacterales livF ko:K01996 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 1MVVC@1224,2MJNZ@213118,2WK03@28221,42M5A@68525,COG0410@1,COG0410@2 NA|NA|NA E ABC transporter PFHLONEA_00961 1167006.UWK_00089 2.9e-86 325.1 Desulfobacterales livG ko:K01995,ko:K01998 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 1MUTY@1224,2MIA1@213118,2WJIS@28221,42NMG@68525,COG0411@1,COG0411@2 NA|NA|NA E Branched-chain amino acid ATP-binding cassette transporter PFHLONEA_00962 1167006.UWK_00090 1.7e-116 426.0 Desulfobacterales ko:K01998 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 1MV66@1224,2MKDG@213118,2WPEP@28221,42TE0@68525,COG4177@1,COG4177@2 NA|NA|NA E Belongs to the binding-protein-dependent transport system permease family PFHLONEA_00963 589865.DaAHT2_0104 1.2e-112 412.9 Desulfobacterales ko:K01997 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 1MU25@1224,2MJJN@213118,2WJU9@28221,42MKP@68525,COG0559@1,COG0559@2 NA|NA|NA E Belongs to the binding-protein-dependent transport system permease family PFHLONEA_00964 1167006.UWK_00092 7.3e-129 467.2 Desulfobacterales ko:K01999 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 1MXR4@1224,2MHQS@213118,2WKJM@28221,42MXX@68525,COG0683@1,COG0683@2 NA|NA|NA E Receptor family ligand binding region PFHLONEA_00965 1121116.KB894775_gene1100 9.4e-20 102.4 Comamonadaceae livK-1 ko:K01999 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 iAF987.Gmet_1823 Bacteria 1MXR4@1224,2VHP9@28216,4ACT4@80864,COG0683@1,COG0683@2 NA|NA|NA E PFAM Extracellular ligand-binding receptor PFHLONEA_00970 1499967.BAYZ01000079_gene888 6.4e-25 120.2 Bacteria ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 ko00000,ko00001,ko03000 Bacteria COG0664@1,COG0664@2 NA|NA|NA T cyclic nucleotide binding PFHLONEA_00971 1502852.FG94_02296 7.5e-37 159.8 Oxalobacteraceae glnB GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006808,GO:0008144,GO:0008150,GO:0009889,GO:0010565,GO:0017076,GO:0019216,GO:0019217,GO:0019222,GO:0030234,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042304,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0046890,GO:0050789,GO:0050790,GO:0050794,GO:0062012,GO:0065007,GO:0065009,GO:0080090,GO:0097159,GO:0097367,GO:0098772,GO:1901265,GO:1901363 ko:K04751,ko:K04752 ko02020,map02020 ko00000,ko00001 Bacteria 1RGWK@1224,2VSEZ@28216,474DH@75682,COG0347@1,COG0347@2 NA|NA|NA K Belongs to the P(II) protein family PFHLONEA_00972 335543.Sfum_0727 7.5e-154 550.4 Syntrophobacterales amt ko:K03320 ko00000,ko02000 1.A.11 iHN637.CLJU_c42670,iYO844.BSU36510 Bacteria 1NR9F@1224,2MRAX@213462,2WIXC@28221,42MFT@68525,COG0004@1,COG0004@2 NA|NA|NA P Ammonium Transporter Family PFHLONEA_00973 1110502.TMO_2111 5.8e-46 191.4 Rhodospirillales Bacteria 1MVKG@1224,2JRT1@204441,2U30N@28211,COG0697@1,COG0697@2 NA|NA|NA EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily PFHLONEA_00974 243231.GSU1004 1.6e-72 280.0 Desulfuromonadales gnfL 2.7.13.3 ko:K07708,ko:K10942 ko02020,ko05111,map02020,map05111 M00497,M00515 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 1NTTH@1224,2WIYS@28221,42MC9@68525,43T97@69541,COG3852@1,COG3852@2 NA|NA|NA T Nitrogen fixation master sensor histidine kinase, PAS domain-containing PFHLONEA_00976 1487923.DP73_14005 8.7e-28 129.8 Peptococcaceae crcB GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 ko:K06199 ko00000,ko02000 1.A.43.1,1.A.43.2,1.A.43.3 Bacteria 1VEH7@1239,24QSV@186801,262VX@186807,COG0239@1,COG0239@2 NA|NA|NA U Important for reducing fluoride concentration in the cell, thus reducing its toxicity PFHLONEA_00977 1121468.AUBR01000001_gene556 1.7e-21 108.2 Thermoanaerobacterales nifU Bacteria 1VAAU@1239,24R29@186801,42GUA@68295,COG0694@1,COG0694@2 NA|NA|NA O PFAM nitrogen-fixing NifU domain protein PFHLONEA_00980 644281.MFS40622_0978 3e-166 591.7 Methanococci Archaea 23QBY@183939,2XVMM@28890,COG0436@1,arCOG01135@2157 NA|NA|NA H PFAM aminotransferase, class I and II PFHLONEA_00981 56780.SYN_00221 6.9e-135 487.3 Syntrophobacterales rlmL GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016423,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.173,2.1.1.264 ko:K07444,ko:K12297 R07234 RC00003 ko00000,ko01000,ko03009 Bacteria 1MUQM@1224,2MQHY@213462,2WJ5S@28221,42NJ1@68525,COG0116@1,COG0116@2 NA|NA|NA L Putative RNA methylase family UPF0020 PFHLONEA_00982 1232410.KI421421_gene3902 1e-18 99.8 Desulfuromonadales Bacteria 1N7GY@1224,2E6J8@1,2WRHG@28221,3316B@2,42V6W@68525,43V7Z@69541 NA|NA|NA PFHLONEA_00983 1121403.AUCV01000046_gene1112 3.2e-192 678.3 Desulfobacterales sulP2 ko:K03321 ko00000,ko02000 2.A.53.3 Bacteria 1MWDF@1224,2MHNW@213118,2WKZE@28221,43AD6@68525,COG0659@1,COG0659@2 NA|NA|NA P Sulfate permease family PFHLONEA_00984 330214.NIDE1012 1.4e-17 96.3 Nitrospirae Bacteria 3J0U3@40117,COG1714@1,COG1714@2 NA|NA|NA S RDD family PFHLONEA_00985 330214.NIDE1013 1.8e-131 475.7 Nitrospirae mreB GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005856,GO:0005886,GO:0007049,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0032505,GO:0042802,GO:0043093,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051301,GO:0051302,GO:0051782,GO:0051983,GO:0065007,GO:0065008,GO:0071944 ko:K03569 ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 Bacteria 3J0BS@40117,COG1077@1,COG1077@2 NA|NA|NA D Actin PFHLONEA_00986 1121405.dsmv_0472 1.2e-37 163.7 Desulfobacterales mreC GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007163,GO:0008150,GO:0008360,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0030428,GO:0031224,GO:0031226,GO:0042546,GO:0043621,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071554,GO:0071840,GO:0071944,GO:0071963 ko:K03570 ko00000,ko03036 9.B.157.1 Bacteria 1N8ZS@1224,2MJMG@213118,2WNTW@28221,42S9I@68525,COG1792@1,COG1792@2 NA|NA|NA M Involved in formation and maintenance of cell shape PFHLONEA_00987 671143.DAMO_3133 6.2e-08 64.3 unclassified Bacteria mreD GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008360,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944 ko:K03571 ko00000,ko03036 9.B.157.1 Bacteria 2NRRJ@2323,COG2891@1,COG2891@2 NA|NA|NA M rod shape-determining protein MreD PFHLONEA_00988 330214.NIDE1016 2.9e-140 505.8 Nitrospirae mrdA GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 ko00000,ko00001,ko01000,ko01011 iAF987.Gmet_0928,iEcE24377_1341.EcE24377A_0661,iPC815.YPO2604 Bacteria 3J0FY@40117,COG0768@1,COG0768@2 NA|NA|NA M Penicillin-binding Protein dimerisation domain PFHLONEA_00989 1123489.AUAN01000007_gene483 1.7e-35 155.6 Negativicutes sfsA GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005975,GO:0006355,GO:0008150,GO:0008152,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0044238,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 6.1.1.21 ko:K01892,ko:K06206 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 1V1GZ@1239,4H3QA@909932,COG1489@1,COG1489@2,COG1833@1,COG1833@2 NA|NA|NA S Belongs to the SfsA family PFHLONEA_00990 289376.THEYE_A1020 1.8e-57 229.9 Bacteria Bacteria 2CB8R@1,2Z90U@2 NA|NA|NA PFHLONEA_00991 909663.KI867150_gene743 1.5e-29 135.6 Syntrophobacterales Bacteria 1N3R6@1224,2MSJP@213462,2WQ9W@28221,42TU3@68525,COG0745@1,COG0745@2 NA|NA|NA KT cheY-homologous receiver domain PFHLONEA_00992 338963.Pcar_2759 2e-56 226.1 Desulfuromonadales Bacteria 1RCM9@1224,2X7RJ@28221,42NUD@68525,43RXF@69541,COG4191@1,COG4191@2 NA|NA|NA T Domain present in phytochromes and cGMP-specific phosphodiesterases. PFHLONEA_00993 123214.PERMA_0605 9.6e-73 280.4 Aquificae rseP ko:K11749 ko02024,ko04112,map02024,map04112 ko00000,ko00001,ko01000,ko01002 Bacteria 2G4YW@200783,COG0308@1,COG0308@2,COG0750@1,COG0750@2,COG3016@1,COG3016@2 NA|NA|NA M Haem-binding uptake, Tiki superfamily, ChaN PFHLONEA_00994 1304885.AUEY01000004_gene991 8.1e-15 87.8 Bacteria Bacteria 2EBYR@1,335Y1@2 NA|NA|NA PFHLONEA_00995 237368.SCABRO_00576 6.3e-11 73.2 Planctomycetes Bacteria 2EGSE@1,2J3TB@203682,33AII@2 NA|NA|NA PFHLONEA_00996 269799.Gmet_3132 1.6e-42 179.5 Desulfuromonadales MA20_27875 ko:K02039,ko:K07220 ko00000 Bacteria 1R4SP@1224,2WPTH@28221,42SPV@68525,43SW8@69541,COG1392@1,COG1392@2 NA|NA|NA P Protein of unknown function DUF47 PFHLONEA_00997 1304885.AUEY01000018_gene1094 4.6e-92 344.7 Deltaproteobacteria pit GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661 ko:K03306 ko00000 2.A.20 Bacteria 1MVXK@1224,2X5HI@28221,42Q5K@68525,COG0306@1,COG0306@2 NA|NA|NA P PFAM phosphate transporter PFHLONEA_00998 357808.RoseRS_4627 4.1e-16 92.8 Chloroflexia 4.2.1.75,4.6.1.1 ko:K01719,ko:K01768,ko:K02584 ko00230,ko00860,ko01100,ko01110,ko01120,ko02020,ko02025,ko04113,ko04213,map00230,map00860,map01100,map01110,map01120,map02020,map02025,map04113,map04213 M00121,M00695 R00089,R00434,R03165 RC00295,RC01861 ko00000,ko00001,ko00002,ko01000,ko03000 Bacteria 2G67M@200795,374WN@32061,COG2203@1,COG2203@2,COG3605@1,COG3605@2,COG3920@1,COG3920@2 NA|NA|NA T ATP-binding region, ATPase domain protein PFHLONEA_00999 330214.NIDE1341 2.8e-09 68.9 Bacteria ko:K11719 ko00000,ko02000 1.B.42.1 Bacteria COG5375@1,COG5375@2 NA|NA|NA S Protein conserved in bacteria PFHLONEA_01000 289376.THEYE_A0231 2.9e-20 105.1 Nitrospirae lptA GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0009279,GO:0010876,GO:0015920,GO:0016020,GO:0017089,GO:0019867,GO:0030288,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0042597,GO:0042802,GO:0044462,GO:0044464,GO:0046836,GO:0051179,GO:0051234,GO:0071702,GO:0071944,GO:1901264 ko:K09774 ko00000,ko02000 1.B.42.1 iB21_1397.B21_03016,iECBD_1354.ECBD_0542,iECB_1328.ECB_03065,iECD_1391.ECD_03065 Bacteria 3J1EG@40117,COG1934@1,COG1934@2 NA|NA|NA S OstA-like protein PFHLONEA_01001 671143.DAMO_1189 2.9e-83 315.1 unclassified Bacteria lptB GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 ko:K01990,ko:K06861 ko02010,map02010 M00254,M00320 ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1,3.A.1 Bacteria 2NNRT@2323,COG1137@1,COG1137@2 NA|NA|NA S lipopolysaccharide transport protein B ATP-binding component of ABC superfamily PFHLONEA_01002 1232410.KI421421_gene3588 4.8e-117 428.3 Desulfuromonadales rpoN ko:K03092 ko02020,ko05111,map02020,map05111 ko00000,ko00001,ko03021 Bacteria 1MW4V@1224,2WJ21@28221,42M3C@68525,43RYZ@69541,COG1508@1,COG1508@2 NA|NA|NA K Sigma-54 factor, Activator interacting domain (AID) PFHLONEA_01003 289376.THEYE_A0234 2.9e-40 171.8 Nitrospirae raiA ko:K03733,ko:K05808,ko:K05809 ko00000,ko03009,ko03036 Bacteria 3J0V7@40117,COG1544@1,COG1544@2 NA|NA|NA J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase PFHLONEA_01004 56780.SYN_00943 2.1e-34 152.1 Syntrophobacterales ptsN 2.7.1.202 ko:K02768,ko:K02769,ko:K02770,ko:K02806 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273 R03232 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1 Bacteria 1RD0E@1224,2MQJW@213462,2WP7H@28221,42SD2@68525,COG1762@1,COG1762@2 NA|NA|NA G PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 PFHLONEA_01005 1144275.COCOR_07138 6.5e-45 188.0 Myxococcales hprK GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 ko:K06023 ko00000,ko01000 Bacteria 1NNN5@1224,2WK54@28221,2YUU0@29,42P9W@68525,COG1493@1,COG1493@2 NA|NA|NA H Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) PFHLONEA_01006 330214.NIDE1346 9.7e-78 297.0 Nitrospirae rapZ GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363 ko:K06958 ko00000,ko03019 Bacteria 3J0IK@40117,COG1660@1,COG1660@2 NA|NA|NA S Displays ATPase and GTPase activities PFHLONEA_01007 1499967.BAYZ01000065_gene6106 7.5e-25 120.2 unclassified Bacteria manX 2.7.1.191,2.7.1.194 ko:K02793,ko:K02794,ko:K02821 ko00051,ko00053,ko00520,ko01100,ko01120,ko02060,map00051,map00053,map00520,map01100,map01120,map02060 M00276,M00283,M00550 R02630,R07671 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.6.1,4.A.7.1 Bacteria 2NRCX@2323,COG2893@1,COG2893@2 NA|NA|NA G PTS system fructose IIA component PFHLONEA_01011 1121447.JONL01000007_gene1235 1e-07 64.3 Desulfovibrionales 5.2.1.8 ko:K01802,ko:K03771 ko00000,ko01000,ko03110 Bacteria 1MVB3@1224,2M8YR@213115,2WMN3@28221,42QXH@68525,COG0760@1,COG0760@2 NA|NA|NA M peptidylprolyl isomerase PFHLONEA_01012 1232410.KI421421_gene3574 3.5e-24 118.6 Desulfuromonadales ko:K09005 ko00000 Bacteria 1R507@1224,2WQ0C@28221,42NQA@68525,43VBI@69541,COG4393@1,COG4393@2 NA|NA|NA S Predicted membrane protein (DUF2318) PFHLONEA_01013 706587.Desti_4478 4.5e-86 325.1 Deltaproteobacteria ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 1R6DP@1224,2WJSB@28221,42PWX@68525,COG0577@1,COG0577@2 NA|NA|NA V MacB-like periplasmic core domain PFHLONEA_01014 913865.DOT_2472 2.3e-63 248.8 Peptococcaceae lolD ko:K02003,ko:K09810 ko02010,map02010 M00255,M00258 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.125 Bacteria 1U9S7@1239,24EX0@186801,2611S@186807,COG1136@1,COG1136@2 NA|NA|NA V ABC transporter PFHLONEA_01015 1232437.KL661978_gene3864 1.9e-75 289.3 Desulfobacterales ko:K06940 ko00000 Bacteria 1R3YG@1224,2MHSQ@213118,2WM96@28221,42NM0@68525,COG0727@1,COG0727@2 NA|NA|NA S Putative zinc- or iron-chelating domain PFHLONEA_01016 1304885.AUEY01000002_gene330 9.4e-45 187.2 Desulfobacterales ko:K06950 ko00000 Bacteria 1RGCM@1224,2MJS4@213118,2WNBA@28221,42RC5@68525,COG1418@1,COG1418@2 NA|NA|NA S mRNA catabolic process PFHLONEA_01017 398767.Glov_1901 3.8e-210 737.6 Deltaproteobacteria guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.3.1.128,6.3.5.2 ko:K01951,ko:K03790 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002,ko03009 iLJ478.TM1820 Bacteria 1MU2A@1224,2WJ6D@28221,42M0I@68525,COG0519@1,COG0519@2 NA|NA|NA F Catalyzes the synthesis of GMP from XMP PFHLONEA_01018 760568.Desku_2042 3.1e-96 358.2 Peptococcaceae ko:K07090 ko00000 Bacteria 1TRFG@1239,258JQ@186801,2605C@186807,COG0730@1,COG0730@2 NA|NA|NA S membrane transporter protein PFHLONEA_01020 289376.THEYE_A1879 1.2e-36 159.1 Bacteria Bacteria COG4802@1,COG4802@2 NA|NA|NA C ferredoxin-thioredoxin reductase activity PFHLONEA_01021 177437.HRM2_41070 5.2e-19 100.1 Desulfobacterales grxC 1.1.98.6 ko:K03676,ko:K07390,ko:K21636 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R11633,R11634,R11635,R11636 RC00613 ko00000,ko00001,ko00002,ko01000,ko03029,ko03110 Bacteria 1NAZM@1224,2MKPI@213118,2WR8X@28221,42VIA@68525,COG0695@1,COG0695@2 NA|NA|NA O PFAM Glutaredoxin PFHLONEA_01024 926550.CLDAP_07200 1.6e-11 75.9 Chloroflexi ko:K19342 ko00000 Bacteria 2G91T@200795,COG4314@1,COG4314@2 NA|NA|NA C NosL PFHLONEA_01026 398767.Glov_3421 2.5e-117 428.7 Deltaproteobacteria Bacteria 1RAQS@1224,2X706@28221,42QQI@68525,COG2206@1,COG2206@2 NA|NA|NA T PFAM Metal-dependent phosphohydrolase, HD PFHLONEA_01027 404380.Gbem_2522 5e-92 344.4 Desulfuromonadales Bacteria 1NU8B@1224,2WIW6@28221,42MEA@68525,43TI7@69541,COG3829@1,COG3829@2 NA|NA|NA KT Domain present in phytochromes and cGMP-specific phosphodiesterases. PFHLONEA_01029 398767.Glov_3557 3e-55 222.2 Deltaproteobacteria ko:K02016 ko02010,map02010 M00240 ko00000,ko00001,ko00002,ko02000 3.A.1.14 Bacteria 1MWVF@1224,2WKNZ@28221,42PQA@68525,COG0614@1,COG0614@2 NA|NA|NA P PFAM periplasmic binding protein PFHLONEA_01031 635013.TherJR_1923 1.5e-218 765.8 Peptococcaceae aspS 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 Bacteria 1TPCN@1239,247Z3@186801,260AT@186807,COG0173@1,COG0173@2 NA|NA|NA J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) PFHLONEA_01033 243231.GSU1322 2.9e-51 208.8 Desulfuromonadales ccdA ko:K06196 ko00000,ko02000 5.A.1.2 Bacteria 1RCP7@1224,2WJCK@28221,42Q7J@68525,43T44@69541,COG0785@1,COG0785@2 NA|NA|NA O PFAM cytochrome c biogenesis protein, transmembrane region PFHLONEA_01034 335543.Sfum_0360 3.3e-23 114.8 Syntrophobacterales ko:K13640 ko00000,ko03000 Bacteria 1NP97@1224,2MSE8@213462,2X38J@28221,43DNH@68525,COG0789@1,COG0789@2 NA|NA|NA K transcriptional regulator, MerR family PFHLONEA_01035 330214.NIDE1573 1.1e-44 186.8 Nitrospirae moaE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.8.1.12 ko:K03635 ko00790,ko01100,ko04122,map00790,map01100,map04122 R09395 RC02507 ko00000,ko00001,ko01000 iAPECO1_1312.APECO1_1305,iEC042_1314.EC042_0869,iEC55989_1330.EC55989_0828,iECABU_c1320.ECABU_c08270,iECED1_1282.ECED1_0750,iECIAI1_1343.ECIAI1_0820,iECIAI39_1322.ECIAI39_0761,iECNA114_1301.ECNA114_0717,iECO103_1326.ECO103_0820,iECO111_1330.ECO111_0846,iECO26_1355.ECO26_0911,iECOK1_1307.ECOK1_0787,iECP_1309.ECP_0799,iECS88_1305.ECS88_0802,iECSE_1348.ECSE_0839,iECSF_1327.ECSF_0711,iECW_1372.ECW_m0841,iEKO11_1354.EKO11_3101,iEcE24377_1341.EcE24377A_0848,iG2583_1286.G2583_1013,iLF82_1304.LF82_1369,iNRG857_1313.NRG857_03500,iSSON_1240.SSON_0764,iUMN146_1321.UM146_13720,iUTI89_1310.UTI89_C0785,iWFL_1372.ECW_m0841,ic_1306.c0867 Bacteria 3J1AN@40117,COG0314@1,COG0314@2 NA|NA|NA H MoaE protein PFHLONEA_01036 1047013.AQSP01000140_gene2495 6.8e-35 155.2 Bacteria htpX ko:K03799 M00743 ko00000,ko00002,ko01000,ko01002 Bacteria COG0501@1,COG0501@2 NA|NA|NA O metalloendopeptidase activity PFHLONEA_01038 484019.THA_1091 6.1e-49 200.7 Thermotogae lemA ko:K03744 ko00000 Bacteria 2GCV5@200918,COG1704@1,COG1704@2 NA|NA|NA S LemA family PFHLONEA_01039 243231.GSU0454 2.6e-88 332.0 Desulfuromonadales mqnD ko:K07083,ko:K11785 ko00130,ko01110,map00130,map01110 R08589 RC02330 ko00000,ko00001,ko01000 Bacteria 1NYEA@1224,2WIMS@28221,42MXB@68525,43TEZ@69541,COG2107@1,COG2107@2 NA|NA|NA H Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) PFHLONEA_01040 1232410.KI421417_gene2743 9.7e-47 193.7 Desulfuromonadales mqnB GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.4.2.1,3.2.2.26,3.2.2.9 ko:K01243,ko:K03784,ko:K11783 ko00130,ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,ko01230,map00130,map00230,map00240,map00270,map00760,map01100,map01110,map01230 M00034,M00609 R00194,R01401,R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R08587,R10244 RC00033,RC00063,RC00122,RC00318 ko00000,ko00001,ko00002,ko01000 Bacteria 1NDXU@1224,2WQX3@28221,42TU4@68525,43UAQ@69541,COG0775@1,COG0775@2 NA|NA|NA F Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2) PFHLONEA_01042 398767.Glov_1270 2.7e-45 189.1 Deltaproteobacteria Bacteria 1RDQH@1224,2A20V@1,2WXN7@28221,30QAU@2,4330X@68525 NA|NA|NA PFHLONEA_01043 394.NGR_c22660 3.8e-18 97.4 Rhizobiaceae Bacteria 1N29P@1224,2UD2U@28211,4BKYH@82115,COG4274@1,COG4274@2 NA|NA|NA S GYD domain PFHLONEA_01045 658088.HMPREF0987_01771 2.4e-27 128.6 unclassified Lachnospiraceae ebgC ko:K12112 ko00052,ko00511,ko01100,map00052,map00511,map01100 R01678 RC00049 ko00000,ko00001 Bacteria 1V8ZW@1239,24JDP@186801,27U9Z@186928,COG2731@1,COG2731@2 NA|NA|NA G Domain of unknown function (DUF386) PFHLONEA_01046 1120948.KB903247_gene4510 1.3e-112 412.9 Pseudonocardiales Bacteria 2GMHR@201174,4DZ6G@85010,COG0604@1,COG0604@2 NA|NA|NA C PFAM Alcohol dehydrogenase PFHLONEA_01047 56780.SYN_00994 1.8e-65 255.8 Syntrophobacterales argS GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 Bacteria 1MU4J@1224,2MQ9N@213462,2WKII@28221,42MTY@68525,COG0018@1,COG0018@2 NA|NA|NA J TIGRFAM Arginyl-tRNA synthetase PFHLONEA_01048 269799.Gmet_0852 8e-141 506.9 Desulfuromonadales tgt GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0008479,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.29 ko:K00773 R03789,R10209 RC00063 ko00000,ko01000,ko03016 iECW_1372.ECW_m0475,iWFL_1372.ECW_m0475 Bacteria 1MUCA@1224,2WIMT@28221,42M5Y@68525,43TNC@69541,COG0343@1,COG0343@2 NA|NA|NA J Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) PFHLONEA_01049 1121396.KB893083_gene441 6.9e-08 63.5 Desulfobacterales yajC GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031522,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 Bacteria 1MZT2@1224,2MKCK@213118,2WR76@28221,42V1U@68525,COG1862@1,COG1862@2 NA|NA|NA U Preprotein translocase subunit PFHLONEA_01050 289376.THEYE_A0280 1.7e-136 493.0 Nitrospirae secD GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 Bacteria 3J09Z@40117,COG0342@1,COG0342@2 NA|NA|NA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA PFHLONEA_01051 330214.NIDE3286 1.5e-92 346.3 Nitrospirae secF GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 ko:K03072,ko:K03074,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 Bacteria 3J0GM@40117,COG0341@1,COG0341@2 NA|NA|NA U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA PFHLONEA_01052 1267534.KB906755_gene4125 7.9e-59 233.4 Acidobacteriia Bacteria 2JN1T@204432,3Y7XM@57723,COG2148@1,COG2148@2 NA|NA|NA M Bacterial sugar transferase PFHLONEA_01053 1267534.KB906755_gene4124 3.2e-125 454.9 Acidobacteriia Bacteria 2JHJI@204432,3Y486@57723,COG0673@1,COG0673@2 NA|NA|NA S Oxidoreductase family, NAD-binding Rossmann fold PFHLONEA_01054 665952.HMPREF1015_02909 2.5e-45 189.1 Bacillus rumA GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070041,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.190 ko:K03215 ko00000,ko01000,ko03009 Bacteria 1TP4H@1239,1ZB9G@1386,4HA6M@91061,COG2265@1,COG2265@2 NA|NA|NA J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family PFHLONEA_01055 909663.KI867150_gene2405 1.9e-136 492.3 Syntrophobacterales adhA 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 Bacteria 1MUTT@1224,2MREJ@213462,2WMDC@28221,42MY6@68525,COG1064@1,COG1064@2 NA|NA|NA C PFAM Alcohol dehydrogenase PFHLONEA_01056 909663.KI867150_gene2931 1.2e-63 250.0 Syntrophobacterales Bacteria 1MXG5@1224,2MRTK@213462,2X201@28221,42M1Y@68525,COG0388@1,COG0388@2 NA|NA|NA S Carbon-nitrogen hydrolase PFHLONEA_01058 690850.Desaf_1218 2.5e-243 848.6 Desulfovibrionales Bacteria 1PKG6@1224,2M8T9@213115,2WJFI@28221,42MY4@68525,COG1924@1,COG1924@2,COG3580@1,COG3580@2,COG3581@1,COG3581@2 NA|NA|NA I ATPase BadF BadG BcrA BcrD type PFHLONEA_01059 1121861.KB899915_gene1845 7.7e-18 97.4 Rhodospirillales groS GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010033,GO:0016032,GO:0016465,GO:0019058,GO:0019068,GO:0032991,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051704,GO:0061077,GO:0101031,GO:1990220 ko:K04078 ko00000,ko03029,ko03110 Bacteria 1MZ2X@1224,2JSPE@204441,2U9AQ@28211,COG0234@1,COG0234@2 NA|NA|NA O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter PFHLONEA_01060 1121405.dsmv_3216 3e-22 112.1 Desulfobacterales Bacteria 1RFAK@1224,2ARUS@1,2MK37@213118,2WNXF@28221,31H6C@2,42RXP@68525 NA|NA|NA S Type I restriction enzyme R protein N terminus (HSDR_N) PFHLONEA_01061 519989.ECTPHS_05831 2.5e-30 138.7 Chromatiales pgpA GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008962,GO:0009058,GO:0009987,GO:0010035,GO:0010038,GO:0016020,GO:0016021,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0030258,GO:0031224,GO:0031226,GO:0032026,GO:0042221,GO:0042577,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0046839,GO:0050896,GO:0071704,GO:0071944,GO:0090407,GO:1901576 3.1.3.27 ko:K01095 ko00564,ko01100,map00564,map01100 R02029 RC00017 ko00000,ko00001,ko01000 iECSP_1301.ECSP_0485,iECUMN_1333.ECUMN_0456,iECs_1301.ECs0471,iG2583_1286.G2583_0529,iPC815.YPO3179,iZ_1308.Z0520 Bacteria 1MZJA@1224,1S68A@1236,1WY89@135613,COG1267@1,COG1267@2 NA|NA|NA I Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) PFHLONEA_01063 401526.TcarDRAFT_1542 6.6e-128 463.8 Firmicutes dsrB 1.8.99.5 ko:K11181 ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120 M00596 R00295,R00861,R08035 RC00065,RC01760 ko00000,ko00001,ko00002,ko01000 Bacteria 1TZD2@1239,COG2221@1,COG2221@2 NA|NA|NA C TIGRFAM sulfite reductase, dissimilatory-type beta subunit PFHLONEA_01064 1232410.KI421415_gene2936 2.3e-32 144.8 Desulfuromonadales Bacteria 1MZN8@1224,2WP4X@28221,42SJF@68525,43U8B@69541,COG0778@1,COG0778@2 NA|NA|NA C Nitroreductase family PFHLONEA_01065 926692.AZYG01000013_gene885 1.1e-12 80.9 Halanaerobiales 3.4.24.40,4.6.1.13 ko:K01406,ko:K01771,ko:K03641,ko:K09860 ko00562,ko01503,map00562,map01503 R03332 RC00017,RC00425 ko00000,ko00001,ko01000,ko01002,ko02000 2.C.1.2 Bacteria 1V907@1239,257CZ@186801,3WC5C@53433,COG0823@1,COG0823@2,COG3018@1,COG3018@2 NA|NA|NA U LPP20 lipoprotein PFHLONEA_01066 743525.TSC_c11640 1.7e-16 92.4 Deinococcus-Thermus Bacteria 1WMI0@1297,COG1917@1,COG1917@2 NA|NA|NA S Cupin domain PFHLONEA_01067 1265505.ATUG01000002_gene2218 3.9e-82 311.6 delta/epsilon subdivisions ada 2.1.1.63 ko:K10778 ko00000,ko01000,ko03000,ko03400 Bacteria 1QYD9@1224,43CBM@68525,COG2207@1,COG2207@2 NA|NA|NA K Bacterial regulatory helix-turn-helix proteins, AraC family PFHLONEA_01068 289376.THEYE_A0033 6.2e-178 630.9 Nitrospirae ko:K07182 ko00000 Bacteria 3J0UW@40117,COG2905@1,COG2905@2 NA|NA|NA T Domain in cystathionine beta-synthase and other proteins. PFHLONEA_01069 945713.IALB_2429 1.1e-22 112.8 Bacteria ko:K02481,ko:K07713,ko:K07714 ko02020,map02020 M00499,M00500 ko00000,ko00001,ko00002,ko02022 Bacteria COG2204@1,COG2204@2 NA|NA|NA T phosphorelay signal transduction system PFHLONEA_01072 1499967.BAYZ01000069_gene1847 5.5e-18 99.4 Bacteria Bacteria COG0791@1,COG0791@2 NA|NA|NA M cysteine-type peptidase activity PFHLONEA_01074 330214.NIDE1103 2.8e-115 421.8 Nitrospirae ilvE 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 3J0BM@40117,COG0115@1,COG0115@2 NA|NA|NA E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family PFHLONEA_01076 909663.KI867150_gene2666 8.9e-65 253.4 Deltaproteobacteria degU Bacteria 1N00U@1224,2WQCS@28221,42U4C@68525,COG2197@1,COG2197@2 NA|NA|NA K helix_turn_helix, Lux Regulon PFHLONEA_01077 909663.KI867150_gene2665 8e-20 103.6 Deltaproteobacteria ko:K03406,ko:K21470 ko02020,ko02030,map02020,map02030 ko00000,ko00001,ko01002,ko01011,ko02035 Bacteria 1Q3D5@1224,2WSZ4@28221,42X4J@68525,COG2203@1,COG2203@2,COG4585@1,COG4585@2 NA|NA|NA T Histidine kinase-like ATPases PFHLONEA_01079 1160718.SU9_20264 3e-20 105.5 Actinobacteria Bacteria 2DUVD@1,2H1X0@201174,33SHM@2 NA|NA|NA PFHLONEA_01080 1160718.SU9_20264 2.9e-07 62.0 Actinobacteria Bacteria 2DUVD@1,2H1X0@201174,33SHM@2 NA|NA|NA PFHLONEA_01081 909663.KI867150_gene214 2e-44 187.2 Syntrophobacterales Bacteria 1NNJ6@1224,2MRCI@213462,2WKWJ@28221,42PBD@68525,COG0457@1,COG0457@2,COG1807@1,COG1807@2 NA|NA|NA M PFAM Tetratricopeptide repeat PFHLONEA_01082 641107.CDLVIII_1828 2e-11 74.7 Clostridiaceae ribD GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0016070,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 1.1.1.193,3.5.4.26 ko:K00082,ko:K01498,ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1624,iLJ478.TM1828 Bacteria 1TP4F@1239,248MM@186801,36DJS@31979,COG0117@1,COG0117@2,COG1985@1,COG1985@2 NA|NA|NA H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate PFHLONEA_01083 331678.Cphamn1_1570 1.2e-67 263.1 Bacteria yrfG GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008477,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016798,GO:0016799,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050483,GO:0050484 3.1.3.5 ko:K20881 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 Bacteria COG1011@1,COG1011@2 NA|NA|NA S phosphatase activity PFHLONEA_01084 913865.DOT_4517 1.8e-34 152.1 Peptococcaceae ko:K00389 ko00000 Bacteria 1VJG8@1239,24SZR@186801,266DQ@186807,COG2149@1,COG2149@2 NA|NA|NA S Domain of unknown function (DUF202) PFHLONEA_01085 1123376.AUIU01000011_gene1039 7.7e-50 203.8 Nitrospirae ko:K05595 ko00000,ko02000 2.A.95.1 Bacteria 3J0UZ@40117,COG2095@1,COG2095@2 NA|NA|NA U MarC family integral membrane protein PFHLONEA_01086 1499967.BAYZ01000181_gene4505 1.9e-56 226.5 unclassified Bacteria 2.7.13.3 ko:K07675 ko02020,map02020 M00473 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 2NPMD@2323,COG4585@1,COG4585@2,COG5002@1,COG5002@2 NA|NA|NA T Histidine kinase PFHLONEA_01087 1499967.BAYZ01000181_gene4506 1.4e-60 239.6 unclassified Bacteria ko:K02282 ko00000,ko02035,ko02044 Bacteria 2NPMZ@2323,COG2197@1,COG2197@2 NA|NA|NA T helix_turn_helix, Lux Regulon PFHLONEA_01088 313624.NSP_1910 2.2e-39 168.3 Nostocales Bacteria 1G5PK@1117,1HSIY@1161,COG0662@1,COG0662@2 NA|NA|NA G Cupin PFHLONEA_01089 316067.Geob_1852 9.8e-78 297.0 Desulfuromonadales Bacteria 1RK7K@1224,2WP5I@28221,42SRK@68525,43UQH@69541,COG1418@1,COG1418@2 NA|NA|NA S Metal-dependent phosphohydrolase PFHLONEA_01090 1499967.BAYZ01000154_gene1483 6.3e-53 214.5 Bacteria Bacteria 2CKE1@1,32T5C@2 NA|NA|NA PFHLONEA_01091 1304872.JAGC01000003_gene2861 3.2e-49 201.4 Desulfovibrionales vdlD 3.1.2.20 ko:K01073 ko00000,ko01000 Bacteria 1RAEQ@1224,2MAJU@213115,2WPPE@28221,42SPA@68525,COG1607@1,COG1607@2 NA|NA|NA I PFAM thioesterase superfamily PFHLONEA_01093 635013.TherJR_1860 4.7e-20 104.0 Peptococcaceae ko:K09131 ko00000 Bacteria 1VFSH@1239,24T87@186801,262RJ@186807,COG1872@1,COG1872@2 NA|NA|NA S Belongs to the UPF0235 family PFHLONEA_01094 1123376.AUIU01000019_gene1282 4e-20 104.8 Nitrospirae divIVA ko:K04074 ko00000,ko03036 Bacteria 3J19M@40117,COG3599@1,COG3599@2 NA|NA|NA D DivIVA protein PFHLONEA_01095 330214.NIDE0771 1.1e-23 115.9 Nitrospirae yggT GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02221 ko00000,ko02044 Bacteria 3J0U5@40117,COG0762@1,COG0762@2 NA|NA|NA S YGGT family PFHLONEA_01096 378806.STAUR_4960 4.7e-82 311.2 Myxococcales proC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_0899,iIT341.HP1158 Bacteria 1R5J1@1224,2WJW9@28221,2YTWD@29,42P7F@68525,COG0345@1,COG0345@2 NA|NA|NA E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline PFHLONEA_01097 439235.Dalk_0394 9.4e-68 263.5 Desulfobacterales yggS GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.5.1.3 ko:K00788,ko:K06997 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 Bacteria 1MWN7@1224,2MJ9P@213118,2WKYN@28221,42PSG@68525,COG0325@1,COG0325@2 NA|NA|NA S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis PFHLONEA_01098 555079.Toce_0966 3.3e-50 205.3 Thermoanaerobacterales yfiH GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016679,GO:0016682,GO:0030312,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0046983,GO:0055114,GO:0071944 ko:K05810 ko00000,ko01000 Bacteria 1TS34@1239,248TD@186801,42FXU@68295,COG1496@1,COG1496@2 NA|NA|NA S Belongs to the multicopper oxidase YfiH RL5 family PFHLONEA_01099 1123288.SOV_1c10280 9.2e-152 543.9 Negativicutes Bacteria 1TQJT@1239,4H23J@909932,COG1032@1,COG1032@2 NA|NA|NA C Radical SAM domain protein PFHLONEA_01100 926569.ANT_17500 3.4e-26 124.4 Chloroflexi ygbA Bacteria 2E4R1@1,2G9B6@200795,32ZJK@2 NA|NA|NA S Nitrous oxide-stimulated promoter PFHLONEA_01101 1123376.AUIU01000004_gene1174 1.3e-112 412.9 Nitrospirae cysM GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0032991,GO:0033847,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.113,2.5.1.47,6.1.1.16 ko:K01883,ko:K12339,ko:K21148 ko00270,ko00920,ko00970,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04122,map00270,map00920,map00970,map01100,map01110,map01120,map01130,map01200,map01230,map04122 M00021,M00359,M00360 R00897,R03132,R03601,R03650,R04859,R10610 RC00020,RC00055,RC00523,RC02814,RC02821,RC02876,RC03225 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 3J0HD@40117,COG0031@1,COG0031@2 NA|NA|NA E Pyridoxal-phosphate dependent enzyme PFHLONEA_01102 243090.RB8978 1.2e-63 250.0 Planctomycetes Bacteria 2IZQK@203682,COG1235@1,COG1235@2 NA|NA|NA S Beta-lactamase superfamily domain PFHLONEA_01104 573061.Clocel_1208 1.8e-23 115.5 Bacteria 1.8.1.9 ko:K00384,ko:K01420 ko00450,map00450 R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000,ko03000 Bacteria COG0664@1,COG0664@2 NA|NA|NA T cyclic nucleotide binding PFHLONEA_01105 243231.GSU1475 1.6e-44 186.4 Desulfuromonadales trmJ GO:0001510,GO:0002128,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.200,3.5.1.19,6.1.1.16 ko:K01883,ko:K02533,ko:K08281,ko:K15396 ko00760,ko00970,ko01100,map00760,map00970,map01100 M00359,M00360 R01268,R03650 RC00055,RC00100,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 1N47Y@1224,2WNTZ@28221,42S9X@68525,43SI1@69541,COG0565@1,COG0565@2 NA|NA|NA J Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA PFHLONEA_01106 589865.DaAHT2_1026 1.7e-58 231.9 Desulfobacterales Bacteria 1RA5G@1224,2MJMB@213118,2WMV9@28221,42QZ8@68525,COG0432@1,COG0432@2 NA|NA|NA S Uncharacterised protein family UPF0047 PFHLONEA_01107 1094508.Tsac_1575 6.8e-76 290.8 Thermoanaerobacterales ftsZ GO:0000166,GO:0000287,GO:0000910,GO:0000921,GO:0000935,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022402,GO:0022607,GO:0030428,GO:0031106,GO:0032153,GO:0032155,GO:0032185,GO:0032506,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0045787,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051258,GO:0051301,GO:0051726,GO:0065003,GO:0065007,GO:0070925,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:1901265,GO:1901363 ko:K03531 ko04112,map04112 ko00000,ko00001,ko02048,ko03036,ko04812 Bacteria 1TP6W@1239,247Z5@186801,42EUU@68295,COG0206@1,COG0206@2 NA|NA|NA D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity PFHLONEA_01108 269799.Gmet_0138 5.6e-13 79.3 Desulfuromonadales Bacteria 1QCVP@1224,2WKD1@28221,42QA4@68525,43SDE@69541,COG5316@1,COG5316@2 NA|NA|NA S Domain of unknown function (DUF4139) PFHLONEA_01109 247490.KSU1_C0203 3.5e-122 444.9 Planctomycetes corA GO:0000041,GO:0000287,GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015087,GO:0015095,GO:0015318,GO:0015693,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0046914,GO:0046915,GO:0050897,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0070838,GO:0071840,GO:0071944,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:1903830 ko:K03284 ko00000,ko02000 1.A.35.1,1.A.35.3 Bacteria 2IX61@203682,COG0598@1,COG0598@2 NA|NA|NA P Mediates influx of magnesium ions PFHLONEA_01110 909663.KI867150_gene853 2.3e-124 451.8 Syntrophobacterales porB 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1R5BF@1224,2MR5B@213462,2WK9C@28221,42MRV@68525,COG1013@1,COG1013@2 NA|NA|NA C Pyruvate ferredoxin oxidoreductase beta subunit C terminal PFHLONEA_01111 269797.Mbar_A2214 8.1e-19 99.4 Methanomicrobia 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 Archaea 2N91I@224756,2XSUJ@28890,COG0674@1,arCOG01606@2157 NA|NA|NA C Pyruvate flavodoxin ferredoxin oxidoreductase domain protein PFHLONEA_01114 1499967.BAYZ01000004_gene4926 2.8e-66 260.0 unclassified Bacteria ko:K02660,ko:K03406 ko02020,ko02025,ko02030,map02020,map02025,map02030 ko00000,ko00001,ko02035,ko02044 Bacteria 2NQVC@2323,COG0840@1,COG0840@2 NA|NA|NA NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). PFHLONEA_01115 572477.Alvin_2915 6e-16 90.9 Chromatiales cheW ko:K02659,ko:K03408 ko02020,ko02025,ko02030,map02020,map02025,map02030 ko00000,ko00001,ko02035,ko02044 Bacteria 1RAH1@1224,1SYDF@1236,1WXZ3@135613,COG0835@1,COG0835@2 NA|NA|NA NT PFAM CheW domain protein PFHLONEA_01116 768670.Calni_0653 1.2e-34 152.5 Deferribacteres Bacteria 2GFWK@200930,COG0745@1,COG0745@2 NA|NA|NA T Twitching motility two-component system response regulator PilH PFHLONEA_01117 1379270.AUXF01000005_gene674 2.6e-22 112.5 Gemmatimonadetes Bacteria 1ZSPN@142182,COG0457@1,COG0457@2 NA|NA|NA S Domain of unknown function (DUF4388) PFHLONEA_01118 330214.NIDE0490 1.1e-76 293.1 Nitrospirae dapB GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.17.1.8 ko:K00215,ko:K03546 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000,ko03400 iIT341.HP0510,iLJ478.TM1520,iSbBS512_1146.SbBS512_E0035 Bacteria 3J0IJ@40117,COG0289@1,COG0289@2 NA|NA|NA E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate PFHLONEA_01119 1125863.JAFN01000001_gene869 9.6e-50 203.8 Deltaproteobacteria 5.3.4.1 ko:K03981 ko00000,ko01000,ko02044,ko03110 3.A.7.11.1 Bacteria 1RD39@1224,2WMZS@28221,42QRZ@68525,COG1651@1,COG1651@2 NA|NA|NA M Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process PFHLONEA_01120 706587.Desti_3075 1.5e-82 312.8 Syntrophobacterales Bacteria 1MUPF@1224,2MQFJ@213462,2WNQ5@28221,42NS5@68525,COG0179@1,COG0179@2 NA|NA|NA Q fumarylacetoacetate (FAA) hydrolase PFHLONEA_01121 647113.Metok_1231 1.6e-161 575.9 Methanococci dapL GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0010285,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0019842,GO:0030170,GO:0033362,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.83 ko:K10206 ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230 M00527 R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 Archaea 23QJF@183939,2XU6A@28890,COG0436@1,arCOG01133@2157 NA|NA|NA E PFAM aminotransferase, class I and II PFHLONEA_01122 755731.Clo1100_1015 2.1e-37 162.2 Clostridiaceae folK 2.7.6.3,4.1.2.25 ko:K00950,ko:K13940 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503,R03504 RC00002,RC00017,RC00721,RC00943 ko00000,ko00001,ko00002,ko01000 iLJ478.TM0041 Bacteria 1V6PR@1239,249YP@186801,36ECT@31979,COG0801@1,COG0801@2 NA|NA|NA H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin PFHLONEA_01123 1144275.COCOR_06037 4.2e-68 264.6 Proteobacteria dgk 2.7.1.113 ko:K15518 ko00230,map00230 R01967 RC00002,RC00017 ko00000,ko00001,ko01000 Bacteria 1RC50@1224,COG1428@1,COG1428@2 NA|NA|NA F Deoxynucleoside kinase PFHLONEA_01125 330214.NIDE3440 8.2e-12 79.0 Nitrospirae Bacteria 3J0MH@40117,COG0457@1,COG0457@2 NA|NA|NA S Tetratricopeptide repeat PFHLONEA_01126 289376.THEYE_A1274 1.2e-69 270.0 Bacteria Bacteria COG1082@1,COG1082@2 NA|NA|NA G myo-inosose-2 dehydratase activity PFHLONEA_01127 1255043.TVNIR_3382 3.2e-17 94.4 Proteobacteria Bacteria 1N6Q9@1224,COG2331@1,COG2331@2 NA|NA|NA S Regulatory protein, FmdB family PFHLONEA_01128 693661.Arcve_0375 1.2e-68 266.9 Archaeoglobi ko:K07022 ko00000 Archaea 246PQ@183980,2XW12@28890,COG2248@1,arCOG00969@2157 NA|NA|NA S Belongs to the UPF0282 family PFHLONEA_01129 926560.KE387023_gene2407 9.9e-37 159.8 Bacteria ko:K06929 ko00000 Bacteria COG1832@1,COG1832@2 NA|NA|NA S CoA binding domain PFHLONEA_01130 1173028.ANKO01000161_gene5032 5.8e-46 191.0 Oscillatoriales ngr Bacteria 1G5YD@1117,1HBFD@1150,COG1592@1,COG1592@2 NA|NA|NA C Rubrerythrin PFHLONEA_01132 331678.Cphamn1_1508 1.7e-36 158.7 Bacteria ko:K06996 ko00000 Bacteria COG3324@1,COG3324@2 NA|NA|NA E translation initiation factor activity PFHLONEA_01133 307480.IW16_12100 1.7e-50 205.7 Chryseobacterium Bacteria 1I32M@117743,3ZR86@59732,4NMXH@976,COG2318@1,COG2318@2 NA|NA|NA S DinB family PFHLONEA_01134 1379698.RBG1_1C00001G1562 1.4e-159 570.1 unclassified Bacteria mrcA GO:0003674,GO:0005488,GO:0005515,GO:0042802 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 ko00000,ko00001,ko01000,ko01003,ko01011 GT51 iAF987.Gmet_0354 Bacteria 2NS4K@2323,COG5009@1,COG5009@2 NA|NA|NA M Transglycosylase PFHLONEA_01135 247490.KSU1_B0443 1.4e-80 305.8 Planctomycetes sod 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 ko00000,ko00001,ko01000 Bacteria 2IX16@203682,COG0605@1,COG0605@2 NA|NA|NA C Destroys radicals which are normally produced within the cells and which are toxic to biological systems PFHLONEA_01136 1379698.RBG1_1C00001G1085 1.4e-38 166.0 unclassified Bacteria 2.5.1.17 ko:K19221 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 Bacteria 2NPNR@2323,COG2109@1,COG2109@2 NA|NA|NA H ATP:corrinoid adenosyltransferase BtuR/CobO/CobP PFHLONEA_01137 330214.NIDE4089 1.5e-106 392.9 Nitrospirae phoH GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K06217 ko00000 Bacteria 3J0AD@40117,COG1702@1,COG1702@2 NA|NA|NA T PhoH-like protein PFHLONEA_01138 118005.AWNK01000001_gene2130 3.1e-102 379.4 Bacteria yqfF ko:K07037 ko00000 Bacteria COG1480@1,COG1480@2 NA|NA|NA O 7TM receptor with intracellular HD hydrolase PFHLONEA_01139 404380.Gbem_0998 2.1e-27 128.6 Desulfuromonadales ybeY GO:0000469,GO:0000478,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006355,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016072,GO:0016151,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0019219,GO:0019222,GO:0019538,GO:0022613,GO:0030490,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043244,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141 2.6.99.2,3.5.4.5 ko:K01489,ko:K03474,ko:K03595,ko:K07042 ko00240,ko00750,ko00983,ko01100,map00240,map00750,map00983,map01100 M00124 R01878,R02485,R05838,R08221 RC00074,RC00514,RC01476 ko00000,ko00001,ko00002,ko01000,ko03009,ko03029 Bacteria 1MZ67@1224,2WQDM@28221,42UZ6@68525,43SKH@69541,COG0319@1,COG0319@2 NA|NA|NA J Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA PFHLONEA_01140 269799.Gmet_2369 2.6e-44 185.7 Desulfuromonadales dgkA 2.7.1.107,2.7.1.66,3.1.3.27,3.1.3.4,3.1.3.81,3.6.1.27 ko:K00887,ko:K00901,ko:K01096,ko:K19302 ko00550,ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00550,map00561,map00564,map01100,map01110,map04070,map04072,map05231 R02029,R02240,R05626,R05627 RC00002,RC00017 ko00000,ko00001,ko01000,ko01011 iAF987.Gmet_2369,iSB619.SA_RS07900 Bacteria 1Q5TS@1224,2WPDT@28221,42SZA@68525,43T24@69541,COG0671@1,COG0671@2,COG0818@1,COG0818@2 NA|NA|NA IM Prokaryotic diacylglycerol kinase PFHLONEA_01142 316067.Geob_3292 8.7e-112 410.2 Desulfuromonadales accA GO:0001676,GO:0003674,GO:0003824,GO:0003989,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009317,GO:0009329,GO:0009987,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0019752,GO:0032787,GO:0032991,GO:0042759,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576,GO:1902494,GO:1990234 2.1.3.15,6.4.1.2 ko:K01962,ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 iAF1260.b0185,iBWG_1329.BWG_0177,iEC55989_1330.EC55989_0179,iECDH10B_1368.ECDH10B_0165,iECDH1ME8569_1439.ECDH1ME8569_0178,iECED1_1282.ECED1_0191,iECH74115_1262.ECH74115_0195,iECIAI1_1343.ECIAI1_0185,iECNA114_1301.ECNA114_0175,iECO111_1330.ECO111_0186,iECO26_1355.ECO26_0187,iECP_1309.ECP_0193,iECSE_1348.ECSE_0184,iECSF_1327.ECSF_0200,iECSP_1301.ECSP_0184,iECW_1372.ECW_m0181,iECs_1301.ECs0187,iEKO11_1354.EKO11_3733,iEcDH1_1363.EcDH1_3418,iEcE24377_1341.EcE24377A_0189,iEcHS_1320.EcHS_A0187,iG2583_1286.G2583_0188,iJN746.PP_1607,iJO1366.b0185,iJR904.b0185,iLF82_1304.LF82_0008,iNRG857_1313.NRG857_00945,iSDY_1059.SDY_0201,iSFV_1184.SFV_0168,iSF_1195.SF0175,iSFxv_1172.SFxv_0185,iS_1188.S0178,iUMNK88_1353.UMNK88_190,iWFL_1372.ECW_m0181,iY75_1357.Y75_RS00935,iZ_1308.Z0197 Bacteria 1MURN@1224,2WKA3@28221,42NC2@68525,43UDE@69541,COG0825@1,COG0825@2 NA|NA|NA I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA PFHLONEA_01143 1121918.ARWE01000001_gene1125 2.9e-124 452.6 delta/epsilon subdivisions 2.7.13.3 ko:K03406,ko:K07710 ko02020,ko02030,map02020,map02030 M00500 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 Bacteria 1NU7E@1224,42NE2@68525,COG5000@1,COG5000@2 NA|NA|NA T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PFHLONEA_01144 335543.Sfum_2695 4.1e-56 224.6 Syntrophobacterales rnfA ko:K03617 ko00000 Bacteria 1MU8X@1224,2MQUT@213462,2WKGX@28221,42PMX@68525,COG4657@1,COG4657@2 NA|NA|NA C Rnf-Nqr subunit, membrane protein PFHLONEA_01145 1121440.AUMA01000007_gene1241 1.7e-55 222.6 Proteobacteria rnfE GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0044464,GO:0055114,GO:0071944 2.3.1.243,4.2.99.18 ko:K02560,ko:K03613,ko:K10773 ko00540,ko01100,ko03410,map00540,map01100,map03410 M00060 R05075 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005,ko03400 iHN637.CLJU_RS05585 Bacteria 1R342@1224,COG4660@1,COG4660@2 NA|NA|NA U Part of a membrane complex involved in electron transport PFHLONEA_01146 401526.TcarDRAFT_1670 5.5e-24 117.9 Negativicutes rnfG GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009279,GO:0016020,GO:0016491,GO:0016651,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0055114,GO:0071944 ko:K03612,ko:K03613,ko:K21559 ko00000,ko03000 Bacteria 1V7R1@1239,4H4F7@909932,COG4659@1,COG4659@2 NA|NA|NA C Part of a membrane complex involved in electron transport PFHLONEA_01147 56780.SYN_01663 9.9e-54 217.2 Syntrophobacterales rnfD 1.6.5.8 ko:K00347,ko:K03614 ko00000,ko01000 Bacteria 1MVY6@1224,2MRG8@213462,2WM8R@28221,42QE5@68525,COG4658@1,COG4658@2 NA|NA|NA C Part of a membrane complex involved in electron transport PFHLONEA_01149 1348583.ATLH01000018_gene2466 3.7e-32 144.8 Cellulophaga Bacteria 1F8H1@104264,1I08A@117743,28H8R@1,2Z7KJ@2,4NGZN@976 NA|NA|NA PFHLONEA_01153 909663.KI867150_gene2427 9.2e-132 477.6 Syntrophobacterales Bacteria 1RCM9@1224,2MR4H@213462,2WIU5@28221,42MC4@68525,COG4191@1,COG4191@2 NA|NA|NA T His Kinase A (phosphoacceptor) domain PFHLONEA_01154 926550.CLDAP_20740 6.4e-60 237.7 Chloroflexi ko:K06889 ko00000 Bacteria 2G9QV@200795,COG1073@1,COG1073@2 NA|NA|NA S Serine aminopeptidase, S33 PFHLONEA_01155 85643.Tmz1t_1470 5.9e-85 320.9 Betaproteobacteria ko:K03286 ko00000,ko02000 1.B.6 Bacteria 1R3Z1@1224,2VV9Q@28216,COG3637@1,COG3637@2 NA|NA|NA M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety PFHLONEA_01158 644282.Deba_2866 2.2e-53 216.1 Deltaproteobacteria ko:K21471 ko00000,ko01000,ko01002,ko01011 Bacteria 1MVTF@1224,2WMA6@28221,42P5W@68525,COG0739@1,COG0739@2 NA|NA|NA M PFAM peptidase PFHLONEA_01160 234267.Acid_7390 8.5e-75 287.0 Acidobacteria Bacteria 3Y6I4@57723,COG1028@1,COG1028@2 NA|NA|NA IQ KR domain PFHLONEA_01161 1499967.BAYZ01000100_gene3436 2.3e-46 191.8 Bacteria Bacteria COG3350@1,COG3350@2 NA|NA|NA T monooxygenase activity PFHLONEA_01162 697282.Mettu_3958 6.7e-53 213.8 Gammaproteobacteria Bacteria 1RGXV@1224,1S6K5@1236,COG5579@1,COG5579@2 NA|NA|NA S Protein of unknown function (DUF1810) PFHLONEA_01163 1121285.AUFK01000019_gene118 1.2e-40 172.9 Flavobacteriia Bacteria 1I23P@117743,4NQDY@976,COG0454@1,COG0456@2 NA|NA|NA K acetyltransferase PFHLONEA_01164 1499967.BAYZ01000025_gene296 1e-20 106.7 Bacteria Bacteria COG0454@1,COG0456@2 NA|NA|NA K acetyltransferase PFHLONEA_01165 395963.Bind_2519 1.3e-61 243.0 Beijerinckiaceae 3.6.3.30 ko:K02010 ko02010,map02010 M00190 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10 Bacteria 1MU3I@1224,2TQMJ@28211,3NB6W@45404,COG3842@1,COG3842@2 NA|NA|NA E TOBE domain PFHLONEA_01166 395963.Bind_2520 3.7e-17 94.0 Beijerinckiaceae ko:K02011,ko:K02012 ko02010,map02010 M00190 ko00000,ko00001,ko00002,ko02000 3.A.1.10 Bacteria 1MWEV@1224,2TVQS@28211,3NCS4@45404,COG1178@1,COG1178@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component PFHLONEA_01167 671143.DAMO_0005 1.1e-39 169.5 unclassified Bacteria ko:K07263 ko00000,ko01000,ko01002 Bacteria 2NP50@2323,COG0612@1,COG0612@2 NA|NA|NA S Insulinase (Peptidase family M16) PFHLONEA_01168 880072.Desac_1033 5.6e-109 401.4 Syntrophobacterales ko:K07263 ko00000,ko01000,ko01002 Bacteria 1MU6R@1224,2MRAF@213462,2X1XQ@28221,42M74@68525,COG0612@1,COG0612@2 NA|NA|NA S Peptidase M16 domain protein PFHLONEA_01171 187272.Mlg_1498 4.4e-57 228.4 Proteobacteria Bacteria 1N2KV@1224,COG2267@1,COG2267@2 NA|NA|NA I Serine aminopeptidase, S33 PFHLONEA_01172 765952.PUV_15640 3.4e-111 408.3 Bacteria 1.6.5.5 ko:K00344 ko00000,ko01000 Bacteria COG0604@1,COG0604@2 NA|NA|NA C NADPH:quinone reductase activity PFHLONEA_01173 1472716.KBK24_0134845 1.6e-70 273.1 Burkholderiaceae Bacteria 1K43D@119060,1PEXH@1224,28HTF@1,2W3AU@28216,2Z80A@2 NA|NA|NA PFHLONEA_01174 671143.DAMO_2539 1e-26 126.3 unclassified Bacteria ko:K07156,ko:K07245,ko:K14166 ko00000,ko02000 9.B.62.1,9.B.62.2 Bacteria 2NPS1@2323,COG1276@1,COG1276@2,COG2372@1,COG2372@2 NA|NA|NA P Evidence 5 No homology to any previously reported sequences PFHLONEA_01175 243159.AFE_2651 2.9e-31 143.7 Bacteria copC ko:K07245,ko:K14166 ko00000,ko02000 9.B.62.1 Bacteria COG1276@1,COG1276@2 NA|NA|NA P copper resistance PFHLONEA_01176 1123242.JH636435_gene1731 1e-59 236.5 Planctomycetes mpg GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.2.2.21 ko:K03652 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 2J0Q4@203682,COG2094@1,COG2094@2 NA|NA|NA L Methylpurine-DNA glycosylase (MPG) PFHLONEA_01177 717231.Flexsi_1286 1.5e-155 557.0 Deferribacteres lolE-2 ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 2GEJY@200930,COG0577@1,COG0577@2,COG4591@1,COG4591@2 NA|NA|NA MV MacB-like periplasmic core domain PFHLONEA_01178 445972.ANACOL_00951 5e-55 221.1 Ruminococcaceae ko:K02003 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 1TP6H@1239,247JJ@186801,3WG7X@541000,COG1136@1,COG1136@2 NA|NA|NA V ABC transporter, ATP-binding protein PFHLONEA_01180 1519464.HY22_00520 1.2e-20 105.9 Bacteria attH Bacteria COG5621@1,COG5621@2 NA|NA|NA S spheroidene biosynthetic process PFHLONEA_01181 635013.TherJR_1590 1.5e-75 289.7 Peptococcaceae ispH 1.17.7.4 ko:K02945,ko:K03527 ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010 M00096,M00178 R05884,R08210 RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko03011 Bacteria 1TQ9N@1239,247UK@186801,26081@186807,COG0539@1,COG0539@2,COG0761@1,COG0761@2 NA|NA|NA IJM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis PFHLONEA_01182 330214.NIDE0426 8.7e-88 330.5 Nitrospirae rpsA 1.17.7.4 ko:K02945,ko:K03527,ko:K07571 ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010 M00096,M00178 R05884,R08210 RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko03011 Bacteria 3J0CA@40117,COG0539@1,COG0539@2,COG1185@1,COG1185@2 NA|NA|NA J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence PFHLONEA_01183 99598.Cal7507_5764 1.2e-87 330.5 Nostocales 6.3.2.14 ko:K02364,ko:K04780,ko:K19103 ko00261,ko01053,ko01110,ko01130,map00261,map01053,map01110,map01130 M00736 R07644,R10880 RC00064,RC00141,RC00162,RC03046,RC03296,RC03297,RC03298 ko00000,ko00001,ko00002,ko01000,ko01008 Bacteria 1G0XE@1117,1HKNU@1161,COG1020@1,COG1020@2,COG3319@1,COG3319@2 NA|NA|NA Q TIGRFAM amino acid adenylation domain PFHLONEA_01184 324925.Ppha_0547 5.6e-83 314.7 Bacteria rgpB ko:K12991,ko:K12997 ko00000,ko01000,ko01003,ko01005 GT2 Bacteria COG0463@1,COG0463@2 NA|NA|NA M Glycosyl transferase, family 2 PFHLONEA_01185 696369.KI912183_gene2082 2.4e-61 243.0 Clostridia Bacteria 1UZ7J@1239,24DZW@186801,COG0438@1,COG0438@2 NA|NA|NA M Glycosyl transferases group 1 PFHLONEA_01186 762968.HMPREF9441_03529 1.3e-31 143.3 Bacteroidetes 2.3.1.79 ko:K00661 ko00000,ko01000 Bacteria 4NQE2@976,COG0110@1,COG0110@2 NA|NA|NA S Transferase hexapeptide repeat PFHLONEA_01187 443143.GM18_1619 4.1e-55 222.2 Proteobacteria Bacteria 1RGJZ@1224,COG0438@1,COG0438@2 NA|NA|NA M PFAM Glycosyl transferase, group 1 PFHLONEA_01188 266748.HY04_10130 5.6e-20 105.5 Bacteria ko:K19431 ko00000,ko01000 Bacteria COG2244@1,COG2244@2 NA|NA|NA S polysaccharide biosynthetic process PFHLONEA_01190 1123392.AQWL01000006_gene638 1.3e-97 363.6 Hydrogenophilales 2.7.13.3 ko:K07709 ko02020,map02020 M00499 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 1KRZ9@119069,1RCM9@1224,2VHTK@28216,COG4191@1,COG4191@2 NA|NA|NA T His Kinase A (phosphoacceptor) domain PFHLONEA_01191 391625.PPSIR1_06828 8.8e-26 124.8 Proteobacteria Bacteria 1NUE4@1224,2C3PE@1,33VDN@2 NA|NA|NA PFHLONEA_01192 1005048.CFU_2785 7.5e-14 83.6 Bacteria Bacteria 2BGVF@1,33DVW@2 NA|NA|NA PFHLONEA_01193 1297742.A176_06104 1.8e-10 72.8 Deltaproteobacteria Bacteria 1NIJH@1224,2WSSA@28221,42XTV@68525,COG5608@1,COG5608@2 NA|NA|NA S Late embryogenesis abundant protein PFHLONEA_01194 909663.KI867150_gene2891 3.9e-75 288.5 Syntrophobacterales flgK ko:K02396 ko02040,map02040 ko00000,ko00001,ko02035 Bacteria 1MZXB@1224,2MQWV@213462,2WM8U@28221,42MTK@68525,COG4786@1,COG4786@2 NA|NA|NA N Protein of unknown function (DUF2950) PFHLONEA_01195 404380.Gbem_2227 2.3e-57 229.9 Deltaproteobacteria dacC 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 ko00000,ko00001,ko01000,ko01002,ko01011 Bacteria 1QVM5@1224,2X7PC@28221,43CDH@68525,COG3115@1,COG3115@2 NA|NA|NA D Protein of unknown function (DUF3300) PFHLONEA_01196 272134.KB731324_gene3218 3.8e-139 502.3 Oscillatoriales Bacteria 1G0SY@1117,1H7V4@1150,COG5001@1,COG5001@2 NA|NA|NA T signal transduction protein containing a membrane domain an EAL and a GGDEF domain PFHLONEA_01198 1304885.AUEY01000031_gene51 6e-40 170.2 Desulfobacterales cusA ko:K07787 ko02020,map02020 ko00000,ko00001,ko02000 2.A.6.1.4 iAF987.Gmet_1547 Bacteria 1NUIV@1224,2MI5E@213118,2WK3X@28221,42NCZ@68525,COG3696@1,COG3696@2 NA|NA|NA P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family PFHLONEA_01200 404589.Anae109_3152 2.2e-64 252.7 Deltaproteobacteria Bacteria 1R7NR@1224,2C0SQ@1,2WW9H@28221,33DUT@2,4319Q@68525 NA|NA|NA PFHLONEA_01201 589865.DaAHT2_2395 1.6e-20 105.5 Deltaproteobacteria ko:K15539 ko00000 Bacteria 1NCYU@1224,2WSDX@28221,42WS1@68525,COG0484@1,COG0484@2,COG1426@1,COG1426@2 NA|NA|NA O Helix-turn-helix domain PFHLONEA_01202 877455.Metbo_1707 6.6e-41 174.1 Euryarchaeota Archaea 2XWS9@28890,COG0500@1,arCOG02702@2157 NA|NA|NA Q Methyltransferase type 11 PFHLONEA_01204 1121918.ARWE01000001_gene691 3e-26 124.4 Deltaproteobacteria Bacteria 1Q6K1@1224,2DREH@1,2WXFM@28221,33BDY@2,433AU@68525 NA|NA|NA PFHLONEA_01205 1121918.ARWE01000001_gene690 1e-24 119.0 Bacteria 1.21.4.1,1.21.4.2 ko:K10672,ko:K10794 ko00330,map00330 R02825 RC00790 ko00000,ko00001,ko01000 Bacteria COG1978@1,COG1978@2 NA|NA|NA S oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor PFHLONEA_01206 330214.NIDE3327 7.8e-20 103.2 Bacteria rbpA Bacteria COG0724@1,COG0724@2 NA|NA|NA K RNA recognition motif PFHLONEA_01208 96561.Dole_3193 6.8e-89 334.7 Desulfobacterales 2.7.11.1,2.7.13.3,3.1.3.3 ko:K03407,ko:K07315,ko:K12132 ko02020,ko02030,map02020,map02030 M00506 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035,ko03021 Bacteria 1NT1K@1224,2MMVQ@213118,2WN0S@28221,42R1P@68525,COG2199@1,COG2199@2,COG3850@1,COG3850@2 NA|NA|NA T PFAM GGDEF domain containing protein PFHLONEA_01220 671143.DAMO_1554 7.4e-116 424.1 unclassified Bacteria yxiO ko:K06902 ko04138,map04138 ko00000,ko00001,ko02000,ko04131 2.A.1.24,9.A.15.1 Bacteria 2NP3G@2323,COG2270@1,COG2270@2 NA|NA|NA S Vacuole effluxer Atg22 like PFHLONEA_01221 1123376.AUIU01000015_gene450 7.9e-27 127.1 Nitrospirae yceD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 ko:K07040 ko00000 Bacteria 3J0UQ@40117,COG1399@1,COG1399@2 NA|NA|NA S Uncharacterized ACR, COG1399 PFHLONEA_01222 439235.Dalk_3305 3.9e-13 80.1 Desulfobacterales rpmF GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904 ko:K02911 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011,ko03029 Bacteria 1NGM1@1224,2MMB1@213118,2WSX6@28221,42XHF@68525,COG0333@1,COG0333@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL32 family PFHLONEA_01223 1499967.BAYZ01000186_gene3963 6.9e-99 367.5 unclassified Bacteria plsX GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.21.4.2,1.21.4.3,1.21.4.4,2.3.1.15 ko:K03621,ko:K21576,ko:K21577 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 2NP1H@2323,COG0416@1,COG0416@2 NA|NA|NA I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA PFHLONEA_01225 1125863.JAFN01000001_gene2493 2.5e-75 288.9 Deltaproteobacteria cbcY Bacteria 1NJEJ@1224,2WK76@28221,42NQM@68525,COG2864@1,COG2864@2 NA|NA|NA C denitrification pathway PFHLONEA_01226 880073.Calab_1598 1.1e-58 233.8 unclassified Bacteria cbcY Bacteria 2NQFM@2323,COG0484@1,COG0484@2,COG2864@1,COG2864@2 NA|NA|NA P Prokaryotic cytochrome b561 PFHLONEA_01227 269799.Gmet_0240 1.3e-22 112.5 Desulfuromonadales ko:K07743 ko00000 Bacteria 1N7JG@1224,2WRD7@28221,42VEP@68525,43VMA@69541,COG3357@1,COG3357@2 NA|NA|NA K transcriptional regulator containing an HTH domain fused to a Zn-ribbon PFHLONEA_01228 941449.dsx2_3369 2.4e-75 288.5 Desulfovibrionales Bacteria 1PM7Y@1224,2M92N@213115,2WNY7@28221,42RD3@68525,COG0346@1,COG0346@2 NA|NA|NA E PFAM Glyoxalase bleomycin resistance protein dioxygenase PFHLONEA_01230 443143.GM18_2447 4e-153 548.5 Deltaproteobacteria atpI GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006873,GO:0006885,GO:0007035,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019725,GO:0019829,GO:0019899,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030003,GO:0030004,GO:0030641,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042592,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044769,GO:0045851,GO:0046034,GO:0046390,GO:0046483,GO:0046961,GO:0048878,GO:0050801,GO:0051117,GO:0051179,GO:0051234,GO:0051452,GO:0051453,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0055086,GO:0065007,GO:0065008,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 ko:K02123 ko00190,ko01100,map00190,map01100 M00159 ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 Bacteria 1QGFB@1224,2X5C3@28221,42UWC@68525,COG1269@1,COG1269@2 NA|NA|NA C PFAM V-type ATPase 116 kDa PFHLONEA_01231 443143.GM18_2448 5.5e-17 93.2 Deltaproteobacteria atpE GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 ko:K02110,ko:K02124 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157,M00159 ko00000,ko00001,ko00002,ko00194 3.A.2.1,3.A.2.2,3.A.2.3 Bacteria 1N5D3@1224,2WY87@28221,438SF@68525,COG0636@1,COG0636@2 NA|NA|NA C PFAM H transporting two-sector ATPase C subunit PFHLONEA_01232 443143.GM18_2449 3.1e-24 118.6 Bacteria atpE ko:K02121 ko00190,ko01100,map00190,map01100 M00159 ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 Bacteria COG1390@1,COG1390@2 NA|NA|NA C Produces ATP from ADP in the presence of a proton gradient across the membrane PFHLONEA_01234 1191523.MROS_0444 6.9e-23 115.2 Bacteria addB 3.6.4.12 ko:K16899 ko00000,ko01000,ko03400 Bacteria COG3857@1,COG3857@2 NA|NA|NA L exonuclease activity PFHLONEA_01237 760142.Hipma_0951 1.1e-31 144.1 Desulfurellales Bacteria 1NJN4@1224,2M7EV@213113,2WTEY@28221,42WXI@68525,COG0526@1,COG0526@2 NA|NA|NA CO COG0526, thiol-disulfide isomerase and thioredoxins PFHLONEA_01238 1203554.HMPREF1476_02117 6e-14 85.1 Sutterellaceae Bacteria 1N8EJ@1224,2VUAF@28216,4PQ9K@995019,COG0589@1,COG0589@2 NA|NA|NA T Universal stress protein family PFHLONEA_01239 580340.Tlie_0607 2.3e-67 262.7 Synergistetes sigA GO:0000988,GO:0000990,GO:0001098,GO:0001101,GO:0001108,GO:0001666,GO:0002791,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006950,GO:0008150,GO:0009266,GO:0009405,GO:0009408,GO:0009410,GO:0009415,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010035,GO:0010468,GO:0010556,GO:0010557,GO:0010565,GO:0010604,GO:0010628,GO:0016020,GO:0016987,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0019899,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032879,GO:0032880,GO:0036293,GO:0040007,GO:0042221,GO:0043175,GO:0043254,GO:0044087,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050708,GO:0050789,GO:0050794,GO:0050896,GO:0051046,GO:0051049,GO:0051128,GO:0051171,GO:0051173,GO:0051223,GO:0051252,GO:0051254,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0070063,GO:0070201,GO:0070482,GO:0071944,GO:0080090,GO:0090087,GO:0097159,GO:0140110,GO:1901363,GO:1901700,GO:1902680,GO:1903506,GO:1903508,GO:1903530,GO:2000112,GO:2000142,GO:2001141 ko:K03086,ko:K03087 ko02026,ko05111,map02026,map05111 ko00000,ko00001,ko03021 Bacteria 3TACS@508458,COG0568@1,COG0568@2 NA|NA|NA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth PFHLONEA_01242 497964.CfE428DRAFT_0707 6.4e-15 87.0 Bacteria Bacteria COG4191@1,COG4191@2 NA|NA|NA T Histidine kinase PFHLONEA_01245 269799.Gmet_3485 2.9e-160 571.6 Desulfuromonadales erfK ko:K16291 ko00000,ko01002,ko01011 Bacteria 1MVYT@1224,2WTVT@28221,42ZCU@68525,43U8N@69541,COG1376@1,COG1376@2 NA|NA|NA S L,D-transpeptidase catalytic domain PFHLONEA_01246 1121440.AUMA01000009_gene680 5.9e-64 250.8 Desulfovibrionales ko:K04767,ko:K07182 ko00000 Bacteria 1RA25@1224,2ME90@213115,2WMW6@28221,42R80@68525,COG0517@1,COG0517@2 NA|NA|NA S Domain in cystathionine beta-synthase and other proteins. PFHLONEA_01247 404380.Gbem_0265 3.2e-189 668.3 Deltaproteobacteria polX ko:K02347 ko00000,ko03400 Bacteria 1MYXV@1224,2WKUP@28221,42MQX@68525,COG1387@1,COG1387@2 NA|NA|NA L DNA polymerase PFHLONEA_01248 909663.KI867150_gene25 7.2e-223 780.0 Deltaproteobacteria pckA 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 Bacteria 1NM41@1224,2WSTH@28221,42WTQ@68525,COG1866@1,COG1866@2 NA|NA|NA C Phosphoenolpyruvate carboxykinase PFHLONEA_01249 247490.KSU1_C0374 8.9e-67 260.4 Planctomycetes nrfJ Bacteria 28PU4@1,2J30W@203682,2ZCF6@2 NA|NA|NA PFHLONEA_01250 1173022.Cri9333_0874 1.4e-17 96.3 Oscillatoriales ko:K03281,ko:K04767,ko:K07182 ko00000 2.A.49 Bacteria 1G5TQ@1117,1HB2G@1150,COG0517@1,COG0517@2 NA|NA|NA S PFAM CBS domain PFHLONEA_01251 243231.GSU1185 3.1e-65 254.6 Desulfuromonadales ko:K09129 ko00000 Bacteria 1RBCB@1224,2WMAS@28221,42S44@68525,43UGI@69541,COG1839@1,COG1839@2 NA|NA|NA S Adenosine specific kinase PFHLONEA_01252 1123376.AUIU01000016_gene330 1.6e-14 85.5 Bacteria Bacteria 28Q1P@1,2ZCJY@2 NA|NA|NA S Zinc dependent phospholipase C PFHLONEA_01256 237368.SCABRO_02227 1.2e-69 270.8 Planctomycetes Bacteria 2IYK4@203682,COG1233@1,COG1233@2 NA|NA|NA C COG1233 Phytoene dehydrogenase and related PFHLONEA_01257 1120948.KB903218_gene2041 2.1e-09 68.2 Pseudonocardiales acpP GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006633,GO:0006637,GO:0006643,GO:0006644,GO:0006664,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009150,GO:0009245,GO:0009247,GO:0009259,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016053,GO:0019637,GO:0019693,GO:0019752,GO:0019842,GO:0030312,GO:0031177,GO:0032787,GO:0033218,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046483,GO:0046493,GO:0048037,GO:0051186,GO:0051192,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072341,GO:0072521,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901360,GO:1901564,GO:1901576,GO:1903509 ko:K02078 ko00000,ko00001 Bacteria 2IQ43@201174,4E5I2@85010,COG0236@1,COG0236@2 NA|NA|NA IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis PFHLONEA_01258 247490.KSU1_C1687 1.9e-127 462.6 Planctomycetes 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 2J1Z9@203682,COG0304@1,COG0304@2 NA|NA|NA I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP PFHLONEA_01259 247490.KSU1_C1688 1.7e-30 139.0 Planctomycetes fabZ 4.2.1.59 ko:K02372 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121 RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 2IZWX@203682,COG0764@1,COG0764@2 NA|NA|NA I 3-hydroxymyristoyl 3-hydroxydecanoyl-(acyl carrier protein) PFHLONEA_01260 237368.SCABRO_02228 1.6e-102 379.8 Planctomycetes 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 2J2GF@203682,COG0304@1,COG0304@2 NA|NA|NA IQ Beta-ketoacyl synthase, C-terminal domain PFHLONEA_01261 247490.KSU1_C1590 3.5e-71 275.0 Planctomycetes Bacteria 2IXE0@203682,COG1028@1,COG1028@2 NA|NA|NA IQ with different specificities (related to short-chain alcohol PFHLONEA_01263 420890.LCGL_1489 1.4e-15 89.4 Lactococcus agaB 2.7.1.191 ko:K02745,ko:K02794 ko00051,ko00052,ko00520,ko01100,ko02060,map00051,map00052,map00520,map01100,map02060 M00276,M00277 R02630,R08366 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.6.1,4.A.6.1.4 Bacteria 1TQJ4@1239,1YCC2@1357,4HI37@91061,COG3444@1,COG3444@2 NA|NA|NA G PTS system sorbose subfamily IIB component PFHLONEA_01264 338963.Pcar_1932 6.5e-17 94.7 Desulfuromonadales ko:K02795 ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060 M00276 R02630 RC00017,RC03206 ko00000,ko00001,ko00002,ko02000 4.A.6.1 Bacteria 1RHFJ@1224,2WPSS@28221,42SZF@68525,43SK0@69541,COG3715@1,COG3715@2 NA|NA|NA G PTS system sorbose-specific iic component PFHLONEA_01265 1242864.D187_001241 1.7e-33 149.8 Deltaproteobacteria manZ ko:K02795,ko:K02796 ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060 M00276 R02630 RC00017,RC03206 ko00000,ko00001,ko00002,ko02000 4.A.6.1 Bacteria 1MWTZ@1224,2WPQN@28221,42SXR@68525,COG3716@1,COG3716@2 NA|NA|NA G system, mannose fructose sorbose family, IID component PFHLONEA_01266 207954.MED92_01564 7e-19 99.8 Oceanospirillales ptsH GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 ko:K02784,ko:K08485,ko:K11189 ko02060,map02060 ko00000,ko00001,ko02000 4.A.2.1,8.A.8.1.1 Bacteria 1N6RM@1224,1SCXX@1236,1XKZ0@135619,COG1925@1,COG1925@2 NA|NA|NA G Phosphocarrier protein HPr PFHLONEA_01267 1232410.KI421421_gene3599 1.2e-164 586.6 Desulfuromonadales ptsI 2.7.3.9 ko:K08483 ko02060,map02060 ko00000,ko00001,ko01000,ko02000 8.A.7 Bacteria 1MUT8@1224,2WK7E@28221,42P77@68525,43RZ6@69541,COG1080@1,COG1080@2 NA|NA|NA G PEP-utilising enzyme, N-terminal PFHLONEA_01268 580340.Tlie_0162 7.6e-75 287.7 Synergistetes cobD 2.6.1.9,4.1.1.81 ko:K00817,ko:K04720 ko00340,ko00350,ko00360,ko00400,ko00401,ko00860,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00860,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243,R06530 RC00006,RC00517,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 iHN637.CLJU_RS15770 Bacteria 3TAGP@508458,COG0079@1,COG0079@2 NA|NA|NA E PFAM Aminotransferase class I and II PFHLONEA_01270 717231.Flexsi_1008 1.5e-07 61.6 Deferribacteres Bacteria 29FYK@1,2GG42@200930,302WA@2 NA|NA|NA PFHLONEA_01271 373903.Hore_01680 5e-93 348.2 Halanaerobiales alr 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 R00401 RC00285 ko00000,ko00001,ko01000,ko01011 Bacteria 1TNYY@1239,2480T@186801,3WADU@53433,COG0787@1,COG0787@2 NA|NA|NA M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids PFHLONEA_01272 909663.KI867150_gene2116 1.5e-69 269.6 Syntrophobacterales ttg2B ko:K02066 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 1MVPN@1224,2MQXR@213462,2WKC9@28221,42MR1@68525,COG0767@1,COG0767@2 NA|NA|NA Q Permease MlaE PFHLONEA_01273 1379698.RBG1_1C00001G0979 6e-84 317.4 unclassified Bacteria mkl ko:K02065 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 2NP3U@2323,COG1127@1,COG1127@2 NA|NA|NA Q ABC-type transport system involved in resistance to organic solvents, ATPase component PFHLONEA_01274 56780.SYN_00409 6.4e-71 275.0 Deltaproteobacteria ko:K02067 ko02010,map02010 M00210,M00669,M00670 ko00000,ko00001,ko00002,ko02000 3.A.1.27 Bacteria 1RFFS@1224,2WKQH@28221,42P4P@68525,COG1463@1,COG1463@2 NA|NA|NA Q ABC-type transport system involved in resistance to organic solvents periplasmic component PFHLONEA_01275 1454004.AW11_01099 5e-26 124.0 Betaproteobacteria Bacteria 1RHCU@1224,2VT7U@28216,COG0745@1,COG0745@2 NA|NA|NA T Pfam Response regulator receiver PFHLONEA_01277 1121924.ATWH01000010_gene1006 4e-10 72.8 Microbacteriaceae Bacteria 2I3GX@201174,4FRMW@85023,COG0500@1,COG0500@2 NA|NA|NA Q O-methyltransferase PFHLONEA_01278 404589.Anae109_2030 1.1e-51 211.5 Deltaproteobacteria 3.1.3.3 ko:K07315 ko00000,ko01000,ko03021 Bacteria 1MUY7@1224,2X7N2@28221,43CC6@68525,COG0591@1,COG0591@2,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor PFHLONEA_01279 1191523.MROS_1493 3.8e-57 229.9 Bacteria Bacteria COG4191@1,COG4191@2 NA|NA|NA T Histidine kinase PFHLONEA_01280 1191523.MROS_1494 2.8e-124 452.2 Bacteria ko:K07714 ko02020,map02020 M00500 ko00000,ko00001,ko00002,ko02022 Bacteria COG2204@1,COG2204@2 NA|NA|NA T phosphorelay signal transduction system PFHLONEA_01282 1150600.ADIARSV_2992 3.2e-18 99.8 Bacteria Bacteria COG1657@1,COG1657@2 NA|NA|NA I PFAM Prenyltransferase squalene oxidase PFHLONEA_01283 909663.KI867149_gene3177 9.6e-127 459.9 Deltaproteobacteria Bacteria 1PC95@1224,2WNBQ@28221,42RHY@68525,COG4313@1,COG4313@2 NA|NA|NA C Putative MetA-pathway of phenol degradation PFHLONEA_01284 909663.KI867149_gene3180 1.5e-59 236.1 Syntrophobacterales Bacteria 1N0AP@1224,28PW7@1,2MR6Z@213462,2WQ2P@28221,32EDN@2,42UF5@68525 NA|NA|NA S Protein of unknown function (DUF3313) PFHLONEA_01285 635013.TherJR_0670 1.5e-211 742.7 Peptococcaceae 1.17.1.10,1.17.1.9 ko:K00123,ko:K05299 ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200 M00377 R00134,R00519 RC02796 ko00000,ko00001,ko00002,ko01000 Bacteria 1TT6D@1239,24YN9@186801,267CA@186807,COG3383@1,COG3383@2 NA|NA|NA C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family PFHLONEA_01286 635013.TherJR_0671 9.5e-64 250.8 Clostridia Bacteria 1TP8R@1239,247QI@186801,COG0479@1,COG0479@2 NA|NA|NA C Sulfite reductase, subunit A PFHLONEA_01287 479437.Elen_1254 5.5e-54 218.0 Coriobacteriia asrB 1.18.1.2,1.19.1.1 ko:K00528,ko:K02823,ko:K16951 ko00240,ko00920,ko01100,ko01120,map00240,map00920,map01100,map01120 R00858,R10146,R10159 RC00065 ko00000,ko00001,ko01000 iHN637.CLJU_RS12555 Bacteria 2HXFY@201174,4CV8F@84998,COG0543@1,COG0543@2 NA|NA|NA C Oxidoreductase NAD-binding domain PFHLONEA_01288 331678.Cphamn1_1832 7.1e-12 76.6 Chlorobi ko:K05386 ko00196,ko01100,map00196,map01100 ko00000,ko00001,ko00194 Bacteria 1FFE4@1090,COG1413@1,COG1413@2 NA|NA|NA C lyase activity PFHLONEA_01289 747365.Thena_0451 2.8e-73 281.6 Thermoanaerobacterales rbr GO:0003674,GO:0005488,GO:0005506,GO:0006950,GO:0006979,GO:0008150,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0050896 Bacteria 1V1FF@1239,248V2@186801,42GAI@68295,COG1592@1,COG1592@2 NA|NA|NA C PFAM Rubrerythrin PFHLONEA_01290 1297742.A176_03691 5.5e-57 228.4 Myxococcales cls ko:K06131 ko00564,ko01100,map00564,map01100 R07390 RC00017 ko00000,ko00001,ko01000 Bacteria 1MWUW@1224,2X5HG@28221,2YUGC@29,43BFU@68525,COG1502@1,COG1502@2 NA|NA|NA I Phospholipase D. Active site motifs. PFHLONEA_01291 1449126.JQKL01000028_gene2588 1.1e-19 103.2 Clostridia ko:K07397 ko00000 Bacteria 1V7SN@1239,24NPX@186801,COG1765@1,COG1765@2 NA|NA|NA O redox protein regulator of disulfide bond formation PFHLONEA_01293 1121468.AUBR01000004_gene114 1.8e-109 402.9 Thermoanaerobacterales mnmE GO:0003674,GO:0005488,GO:0005515,GO:0042802 ko:K03650 R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 Bacteria 1TPJF@1239,248A9@186801,42FFQ@68295,COG0486@1,COG0486@2 NA|NA|NA J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 PFHLONEA_01298 1499967.BAYZ01000014_gene6356 6.1e-126 457.6 unclassified Bacteria pfp GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008443,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0046835,GO:0046872,GO:0047334,GO:0071704,GO:1901135 2.7.1.11,2.7.1.90 ko:K00850,ko:K00895,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 Bacteria 2NNXU@2323,COG0205@1,COG0205@2 NA|NA|NA G Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions PFHLONEA_01299 1150474.JQJI01000005_gene278 1.3e-20 106.3 Thermotogae Bacteria 2GDF8@200918,COG1633@1,COG1633@2 NA|NA|NA S Rubrerythrin PFHLONEA_01300 215803.DB30_4809 3.4e-50 205.3 Myxococcales Bacteria 1R8KN@1224,2X9W7@28221,2YYMU@29,43A76@68525,COG0726@1,COG0726@2 NA|NA|NA G Polysaccharide deacetylase PFHLONEA_01301 1048339.KB913029_gene2175 2.2e-38 165.6 Frankiales bldKE ko:K02032,ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 2H4BW@201174,4EUB4@85013,COG4608@1,COG4608@2 NA|NA|NA P Oligopeptide/dipeptide transporter, C-terminal region PFHLONEA_01302 204536.SULAZ_1094 1.3e-134 486.1 Aquificae 1.1.1.1 ko:K00001 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 Bacteria 2G4NX@200783,COG0604@1,COG0604@2 NA|NA|NA C Alcohol dehydrogenase PFHLONEA_01303 1163617.SCD_n02100 0.0 1131.3 Betaproteobacteria glgP GO:0000272,GO:0003674,GO:0003824,GO:0004645,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0005977,GO:0005980,GO:0006073,GO:0006091,GO:0006112,GO:0008144,GO:0008150,GO:0008152,GO:0008184,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0015980,GO:0016052,GO:0016740,GO:0016757,GO:0016758,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901575 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 R02111 ko00000,ko00001,ko01000 GT35 Bacteria 1MW4J@1224,2VJIJ@28216,COG0058@1,COG0058@2 NA|NA|NA G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties PFHLONEA_01304 909663.KI867150_gene64 4.3e-82 312.0 Syntrophobacterales Bacteria 1Q1F4@1224,2MRMW@213462,2WK3P@28221,42NUU@68525,COG1538@1,COG1538@2 NA|NA|NA MU Outer membrane efflux protein PFHLONEA_01306 289376.THEYE_A0953 4e-78 298.9 Nitrospirae rpoD ko:K03086 ko00000,ko03021 Bacteria 3J0E4@40117,COG0568@1,COG0568@2 NA|NA|NA K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released PFHLONEA_01309 1232410.KI421428_gene1164 4.4e-102 377.9 Desulfuromonadales argB GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0030312,GO:0031406,GO:0034618,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS10565,iJN678.argB,iLJ478.TM1784 Bacteria 1MU17@1224,2WKBC@28221,42N8G@68525,43SC9@69541,COG0548@1,COG0548@2 NA|NA|NA E Amino acid kinase family PFHLONEA_01310 289376.THEYE_A1397 1.1e-112 412.9 Nitrospirae hslU GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019904,GO:0022607,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043335,GO:0043933,GO:0044085,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1904949,GO:1905368,GO:1905369 ko:K03667 ko00000,ko03110 Bacteria 3J0XE@40117,COG1220@1,COG1220@2 NA|NA|NA O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis PFHLONEA_01311 289376.THEYE_A1355 1.7e-175 622.1 Nitrospirae tuf GO:0001666,GO:0001817,GO:0001819,GO:0002791,GO:0002793,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0006950,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009274,GO:0009275,GO:0009628,GO:0009986,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0010339,GO:0010467,GO:0016020,GO:0019538,GO:0019899,GO:0022610,GO:0030312,GO:0032677,GO:0032757,GO:0032879,GO:0032880,GO:0034641,GO:0034645,GO:0035375,GO:0035821,GO:0036293,GO:0040007,GO:0042221,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044003,GO:0044068,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044403,GO:0044406,GO:0044419,GO:0044424,GO:0044426,GO:0044444,GO:0044462,GO:0044464,GO:0044650,GO:0044651,GO:0048518,GO:0048522,GO:0050707,GO:0050708,GO:0050714,GO:0050715,GO:0050789,GO:0050794,GO:0050896,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051222,GO:0051223,GO:0051239,GO:0051240,GO:0051701,GO:0051704,GO:0051817,GO:0065007,GO:0070201,GO:0070482,GO:0071704,GO:0071944,GO:0090087,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903530,GO:1903532,GO:1904951,GO:2000482,GO:2000484 ko:K02358,ko:K15771 ko02010,map02010 M00491 ko00000,ko00001,ko00002,ko02000,ko03012,ko03029,ko04147 3.A.1.1.16,3.A.1.1.2 iSB619.SA_RS02960 Bacteria 3J0DG@40117,COG0050@1,COG0050@2 NA|NA|NA J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis PFHLONEA_01313 1123376.AUIU01000005_gene1198 5.4e-67 260.8 Nitrospirae rplC GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010604,GO:0010628,GO:0015934,GO:0016020,GO:0016043,GO:0019219,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0031323,GO:0031325,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000232,GO:2000234 ko:K02906 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0HP@40117,COG0087@1,COG0087@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit PFHLONEA_01314 879308.HMPREF9130_0670 4.3e-51 208.0 Peptoniphilaceae rplD GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003700,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0005886,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008428,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030234,GO:0030312,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032069,GO:0032074,GO:0032268,GO:0032269,GO:0032991,GO:0032993,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042788,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060698,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0065003,GO:0065007,GO:0065009,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:0098772,GO:0140110,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990904,GO:2000112,GO:2000113,GO:2001141 ko:K02926,ko:K16193 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1TPGW@1239,22GGG@1570339,248SY@186801,COG0088@1,COG0088@2 NA|NA|NA J Forms part of the polypeptide exit tunnel PFHLONEA_01315 644282.Deba_2936 5.7e-22 110.2 Deltaproteobacteria rplW GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02892 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1MZXX@1224,2WRMX@28221,42V3Y@68525,COG0089@1,COG0089@2 NA|NA|NA J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome PFHLONEA_01316 338966.Ppro_0683 4e-105 387.9 Desulfuromonadales rplB GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02886 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1MVTD@1224,2WIRE@28221,42MBV@68525,43T1S@69541,COG0090@1,COG0090@2 NA|NA|NA J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity PFHLONEA_01317 1131269.AQVV01000036_gene1504 1.4e-26 125.2 Bacteria rpsS GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02965 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria COG0185@1,COG0185@2 NA|NA|NA J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA PFHLONEA_01318 1122918.KB907246_gene1513 6.6e-27 126.7 Paenibacillaceae rplV GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042788,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02890 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V6PU@1239,26XGA@186822,4HIK2@91061,COG0091@1,COG0091@2 NA|NA|NA J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome PFHLONEA_01319 404380.Gbem_0939 1.4e-86 325.9 Desulfuromonadales rpsC GO:0000028,GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02982 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1MUAI@1224,2WIU3@28221,42N5W@68525,43T5Z@69541,COG0092@1,COG0092@2 NA|NA|NA J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation PFHLONEA_01320 1347392.CCEZ01000013_gene2683 3.8e-56 224.2 Clostridiaceae rplP GO:0000027,GO:0000049,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02878 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V1AY@1239,24FQX@186801,36E4K@31979,COG0197@1,COG0197@2 NA|NA|NA J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs PFHLONEA_01321 1449126.JQKL01000050_gene2683 6.8e-11 72.8 unclassified Clostridiales rpmC GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02904 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1VEME@1239,24QV1@186801,269WW@186813,COG0255@1,COG0255@2 NA|NA|NA J Ribosomal L29 protein PFHLONEA_01322 1048834.TC41_3032 2.5e-24 117.9 Alicyclobacillaceae rpsQ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02961 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V9YC@1239,27A6H@186823,4HKDN@91061,COG0186@1,COG0186@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA PFHLONEA_01323 1417296.U879_04570 4.1e-46 190.7 Alphaproteobacteria rplN GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02874 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1RCWZ@1224,2U743@28211,COG0093@1,COG0093@2 NA|NA|NA J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome PFHLONEA_01324 338963.Pcar_0712 1.6e-27 128.6 Desulfuromonadales rplX GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02895 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1MZQD@1224,2WQ2G@28221,42TGC@68525,43VB6@69541,COG0198@1,COG0198@2 NA|NA|NA J Ribosomal proteins 50S L24/mitochondrial 39S L24 PFHLONEA_01325 330214.NIDE1323 8.5e-67 260.4 Nitrospirae rplE GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02931 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0HN@40117,COG0094@1,COG0094@2 NA|NA|NA J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits PFHLONEA_01326 243159.AFE_0340 7.4e-20 102.4 Acidithiobacillales rpsN GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02954 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1QCYE@1224,1T8SG@1236,2NDCD@225057,COG0199@1,COG0199@2 NA|NA|NA J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site PFHLONEA_01327 269799.Gmet_0640 5.6e-41 173.7 Desulfuromonadales rpsH GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009894,GO:0009987,GO:0010467,GO:0010468,GO:0010608,GO:0015935,GO:0016043,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031323,GO:0031329,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043487,GO:0043488,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0061013,GO:0065003,GO:0065007,GO:0065008,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903311,GO:1990904 ko:K02994 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1RDG3@1224,2WPDP@28221,42SF6@68525,43V2C@69541,COG0096@1,COG0096@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit PFHLONEA_01328 1341151.ASZU01000021_gene1308 6.8e-53 213.8 Thermoactinomycetaceae rplF GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02933 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V1FC@1239,27ATZ@186824,4HFQD@91061,COG0097@1,COG0097@2 NA|NA|NA J Ribosomal protein L6 PFHLONEA_01329 1157490.EL26_19235 2.2e-31 141.7 Alicyclobacillaceae rplR GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02881 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V6DM@1239,278GU@186823,4HIGF@91061,COG0256@1,COG0256@2 NA|NA|NA J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance PFHLONEA_01330 644966.Tmar_2278 1.1e-49 203.0 Clostridiales incertae sedis rpsE GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990145,GO:1990904 ko:K02988 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V1B1@1239,24G5D@186801,3WCJ1@538999,COG0098@1,COG0098@2 NA|NA|NA J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body PFHLONEA_01331 246194.CHY_2291 6e-12 76.3 Thermoanaerobacterales rpmD GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02907 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1VEG4@1239,24QKC@186801,42HG7@68295,COG1841@1,COG1841@2 NA|NA|NA J Ribosomal protein L30 PFHLONEA_01332 273068.TTE2273 1.8e-48 198.7 Thermoanaerobacterales rplO GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02876 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V3KE@1239,24HAJ@186801,42G84@68295,COG0200@1,COG0200@2 NA|NA|NA J Binds to the 23S rRNA PFHLONEA_01333 289376.THEYE_A1427 3.5e-158 564.7 Nitrospirae secY GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5 Bacteria 3J0C0@40117,COG0201@1,COG0201@2 NA|NA|NA U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently PFHLONEA_01334 330214.NIDE1333 6.8e-80 303.9 Nitrospirae map 3.4.11.18 ko:K01265 ko00000,ko01000,ko01002 Bacteria 3J0GR@40117,COG0024@1,COG0024@2 NA|NA|NA J Metallopeptidase family M24 PFHLONEA_01335 1162668.LFE_0905 2.9e-31 140.6 Nitrospirae infA GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009986,GO:0030246,GO:0030247,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:2001065 ko:K02518 ko00000,ko03012 Bacteria 3J0QB@40117,COG0361@1,COG0361@2 NA|NA|NA J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex PFHLONEA_01336 56780.SYN_01598 4e-39 167.5 Syntrophobacterales rpsM GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02952 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1RD1G@1224,2MRU2@213462,2WPD5@28221,42RE3@68525,COG0099@1,COG0099@2 NA|NA|NA J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits PFHLONEA_01337 1121405.dsmv_3566 2.6e-48 198.0 Desulfobacterales rpsK GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02948 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1RD0A@1224,2MJYB@213118,2WPH1@28221,42R43@68525,COG0100@1,COG0100@2 NA|NA|NA J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome PFHLONEA_01338 443143.GM18_0858 1e-76 293.1 Deltaproteobacteria rpsD GO:0000028,GO:0000900,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006355,GO:0006412,GO:0006417,GO:0006446,GO:0006450,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0010629,GO:0015935,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030371,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031554,GO:0031564,GO:0032268,GO:0032269,GO:0032270,GO:0032991,GO:0034248,GO:0034249,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043244,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0045727,GO:0045903,GO:0045947,GO:0048027,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051247,GO:0051248,GO:0051252,GO:0060255,GO:0065003,GO:0065007,GO:0065008,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090079,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990145,GO:1990904,GO:2000112,GO:2000113,GO:2001141 ko:K02986 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1MW0U@1224,2WJGN@28221,42M5X@68525,COG0522@1,COG0522@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit PFHLONEA_01339 671143.DAMO_1662 1.7e-38 166.4 Bacteria Bacteria COG3794@1,COG3794@2 NA|NA|NA C PFAM blue (type 1) copper domain protein PFHLONEA_01341 379066.GAU_0606 7.2e-79 300.8 Gemmatimonadetes ko:K02033 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 1ZSXJ@142182,COG0601@1,COG0601@2 NA|NA|NA U Binding-protein-dependent transport system inner membrane component PFHLONEA_01342 171693.BN988_01722 5.7e-67 261.2 Oceanobacillus gsiD_1 ko:K02034 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 1TP4R@1239,23JB7@182709,4HBB9@91061,COG1173@1,COG1173@2 NA|NA|NA EP N-terminal TM domain of oligopeptide transport permease C PFHLONEA_01343 1121423.JONT01000015_gene1315 1.7e-60 239.6 Peptococcaceae ksgA GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 ko:K02528,ko:K15256 R10716 RC00003,RC03257 ko00000,ko01000,ko03009,ko03016 Bacteria 1TP9W@1239,248RY@186801,2609K@186807,COG0030@1,COG0030@2 NA|NA|NA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits PFHLONEA_01344 289376.THEYE_A0660 6.5e-62 243.8 Nitrospirae gmhA 5.3.1.28 ko:K03271 ko00540,ko01100,map00540,map01100 M00064 R05645,R09768,R09769 RC00434 ko00000,ko00001,ko00002,ko01000,ko01005 Bacteria 3J0HG@40117,COG0279@1,COG0279@2 NA|NA|NA G Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate PFHLONEA_01345 330214.NIDE4314 9e-98 363.6 Bacteria Bacteria COG1899@1,COG1899@2 NA|NA|NA O peptidyl-lysine modification to peptidyl-hypusine PFHLONEA_01346 867903.ThesuDRAFT_01574 1.1e-87 330.5 Clostridiales incertae sedis citZ 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1TPPS@1239,24865@186801,3WD3X@538999,COG0372@1,COG0372@2 NA|NA|NA C Citrate synthase, C-terminal domain PFHLONEA_01347 269799.Gmet_0945 3.4e-08 64.3 Desulfuromonadales Bacteria 1QUKY@1224,2WKIY@28221,42NYY@68525,43U2P@69541,COG2199@1,COG3706@2 NA|NA|NA T Response receiver-modulated nucleotide cyclase, GGDEF-related domain-containing PFHLONEA_01348 269799.Gmet_3185 2e-34 152.1 Desulfuromonadales napF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0044424,GO:0044464,GO:0050896 ko:K02572 ko00000 Bacteria 1PW12@1224,2WN0W@28221,42MZ9@68525,43SWA@69541,COG1145@1,COG1145@2 NA|NA|NA C 4Fe-4S binding domain PFHLONEA_01350 795359.TOPB45_0384 9.7e-172 609.8 Thermodesulfobacteria hao GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006091,GO:0006807,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015975,GO:0015980,GO:0016491,GO:0016661,GO:0016663,GO:0019329,GO:0019331,GO:0034641,GO:0042597,GO:0044237,GO:0044281,GO:0044464,GO:0045333,GO:0047991,GO:0055114 1.7.2.6 ko:K10535 ko00910,ko01120,map00910,map01120 M00528,M00804 R10164 RC00383 ko00000,ko00001,ko00002,ko01000 Bacteria 2GHFZ@200940,COG3303@1,COG3303@2 NA|NA|NA P Seven times multi-haem cytochrome CxxCH PFHLONEA_01351 909663.KI867150_gene1852 1.1e-52 213.0 Syntrophobacterales ko:K06910 ko00000 Bacteria 1N0Y4@1224,2MRWT@213462,2X5P0@28221,42T3J@68525,COG1881@1,COG1881@2 NA|NA|NA S Phosphatidylethanolamine-binding protein PFHLONEA_01352 589865.DaAHT2_2396 1.3e-115 422.9 Desulfobacterales ko:K04562 ko00000,ko02035 Bacteria 1R8IW@1224,2MKRR@213118,2WMNY@28221,42R3H@68525,COG0455@1,COG0455@2 NA|NA|NA D NUBPL iron-transfer P-loop NTPase PFHLONEA_01353 443144.GM21_1927 3.7e-45 188.3 Desulfuromonadales scpB GO:0003674,GO:0005488,GO:0005515,GO:0042802 ko:K06024 ko00000,ko03036 Bacteria 1PUA6@1224,2WPFX@28221,42SVD@68525,43US2@69541,COG1386@1,COG1386@2 NA|NA|NA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves PFHLONEA_01355 330214.NIDE1417 1.3e-60 240.0 Nitrospirae scpA ko:K05896 ko00000,ko03036 Bacteria 3J13J@40117,COG1354@1,COG1354@2 NA|NA|NA D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves PFHLONEA_01356 941449.dsx2_1906 4.7e-84 318.2 Desulfovibrionales Bacteria 1MVPF@1224,2M8MX@213115,2WJHA@28221,42PCV@68525,COG0515@1,COG0515@2 NA|NA|NA KLT serine threonine protein kinase PFHLONEA_01357 1121439.dsat_0308 5.6e-19 100.9 Desulfovibrionales Bacteria 1N2H4@1224,2MBBS@213115,2WQV7@28221,42UE7@68525,COG0589@1,COG0589@2 NA|NA|NA T Belongs to the universal stress protein A family PFHLONEA_01362 269799.Gmet_1586 1.8e-123 449.1 Desulfuromonadales infB ko:K02519 ko00000,ko03012,ko03029 Bacteria 1MV26@1224,2WIIX@28221,42M5Q@68525,43UH5@69541,COG0532@1,COG0532@2 NA|NA|NA J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex PFHLONEA_01363 1379698.RBG1_1C00001G1154 1.1e-22 112.5 unclassified Bacteria ylxP ko:K09764 ko00000 Bacteria 2NPYX@2323,COG1550@1,COG1550@2 NA|NA|NA S Protein of unknown function (DUF503) PFHLONEA_01364 926561.KB900623_gene1086 2e-27 128.6 Halanaerobiales rbfA GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0030490,GO:0033554,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043021,GO:0043024,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071840,GO:0090304,GO:1901360 ko:K02834 ko00000,ko03009 Bacteria 1VA0P@1239,24MPB@186801,3WAT9@53433,COG0858@1,COG0858@2 NA|NA|NA J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA PFHLONEA_01365 1232410.KI421413_gene520 2.5e-69 269.2 Desulfuromonadales nrnA GO:0008150,GO:0040007 3.1.13.3,3.1.3.7 ko:K06881 ko00920,ko01100,ko01120,map00920,map01100,map01120 R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03400 Bacteria 1RAUQ@1224,2WN0X@28221,42RKG@68525,43TAU@69541,COG0618@1,COG0618@2 NA|NA|NA S PFAM phosphoesterase, RecJ domain protein PFHLONEA_01366 485913.Krac_11250 5.7e-65 254.6 Chloroflexi truB GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 ko:K03177 ko00000,ko01000,ko03016 Bacteria 2G6F4@200795,COG0130@1,COG0130@2 NA|NA|NA J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs PFHLONEA_01367 1031288.AXAA01000001_gene2309 1.2e-26 125.6 Clostridiaceae rpsO GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006378,GO:0006396,GO:0006397,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016071,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031123,GO:0031124,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043631,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02956 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1VA5C@1239,24MRM@186801,36KHC@31979,COG0184@1,COG0184@2 NA|NA|NA J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome PFHLONEA_01370 1167006.UWK_00372 3.1e-79 302.4 Desulfobacterales Bacteria 1RE2G@1224,2MNN1@213118,2WNCP@28221,42S6Z@68525,COG2206@1,COG2206@2 NA|NA|NA T Metal dependent phosphohydrolases with conserved 'HD' motif. PFHLONEA_01371 338963.Pcar_1178 5.8e-69 269.2 Desulfuromonadales Bacteria 1N5TU@1224,2WQ3K@28221,42UDF@68525,43TQ4@69541,COG1413@1,COG1413@2 NA|NA|NA C lyase activity PFHLONEA_01373 421052.F945_02691 8.2e-40 170.6 Moraxellaceae mtnX 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1REUD@1224,1S47B@1236,3NJZ2@468,COG4359@1,COG4359@2 NA|NA|NA E Putative Phosphatase PFHLONEA_01375 667014.Thein_0246 6.3e-73 280.4 Thermodesulfobacteria rtcB 6.5.1.3 ko:K14415 ko00000,ko01000,ko03016 Bacteria 2GH7Q@200940,COG1690@1,COG1690@2 NA|NA|NA S Belongs to the RtcB family PFHLONEA_01376 1123376.AUIU01000011_gene1074 8.9e-37 160.2 Bacteria nucH GO:0003674,GO:0003824,GO:0004518,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:1901360,GO:1901361,GO:1901575 3.1.31.1 ko:K01174 ko00000,ko01000 Bacteria COG1525@1,COG1525@2 NA|NA|NA L nuclease PFHLONEA_01377 909663.KI867150_gene2915 2.4e-77 295.8 Syntrophobacterales ko:K01993,ko:K02005 ko00000 Bacteria 1QU7Z@1224,2MSKN@213462,2X70W@28221,43BPM@68525,COG1566@1,COG1566@2 NA|NA|NA V HlyD family secretion protein PFHLONEA_01378 269799.Gmet_3463 3e-122 444.9 Deltaproteobacteria ko:K01990,ko:K13926 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1MUX3@1224,2WKFC@28221,42PIB@68525,COG1131@1,COG1131@2 NA|NA|NA V Abc transporter PFHLONEA_01381 497964.CfE428DRAFT_0682 1.2e-26 126.7 Bacteria Bacteria 29828@1,2ZV88@2 NA|NA|NA PFHLONEA_01382 485913.Krac_0377 2.4e-59 235.7 Bacteria Bacteria COG0596@1,COG0596@2 NA|NA|NA S hydrolase activity, acting on ester bonds PFHLONEA_01383 1123023.JIAI01000032_gene4171 4.6e-34 151.0 Pseudonocardiales Bacteria 2I9K8@201174,4E2C6@85010,COG1233@1,COG1233@2 NA|NA|NA Q Flavin containing amine oxidoreductase PFHLONEA_01384 880072.Desac_1220 2.7e-56 225.7 Syntrophobacterales Bacteria 1RA7K@1224,2MSCK@213462,2WR88@28221,42V2P@68525,COG0589@1,COG0589@2 NA|NA|NA T Universal stress protein PFHLONEA_01385 1123368.AUIS01000031_gene1418 5.3e-142 510.8 Acidithiobacillales ko:K07090 ko00000 Bacteria 1MWX2@1224,1T8C8@1236,2NCKI@225057,COG0730@1,COG0730@2 NA|NA|NA S Sulfite exporter TauE/SafE PFHLONEA_01386 795359.TOPB45_1244 4.1e-13 80.5 Bacteria Bacteria 2EGXE@1,33APK@2 NA|NA|NA PFHLONEA_01390 877455.Metbo_0900 1.2e-39 170.6 Methanobacteria Archaea 23PQI@183925,2Y42S@28890,COG0463@1,arCOG01381@2157 NA|NA|NA M PFAM Glycosyl transferase family 2 PFHLONEA_01391 1379698.RBG1_1C00001G1492 7.5e-21 105.9 unclassified Bacteria cspA ko:K03704 ko00000,ko03000 Bacteria 2NPXP@2323,COG1278@1,COG1278@2 NA|NA|NA K 'Cold-shock' DNA-binding domain PFHLONEA_01392 1232410.KI421413_gene937 9.5e-55 220.7 Desulfuromonadales yebA2 ko:K21471 ko00000,ko01000,ko01002,ko01011 Bacteria 1MVTF@1224,2WMA6@28221,42P5W@68525,43SFK@69541,COG0739@1,COG0739@2 NA|NA|NA M Peptidase family M23 PFHLONEA_01393 289376.THEYE_A1820 3.3e-23 114.4 Nitrospirae cutA GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0010035,GO:0010038,GO:0016043,GO:0022607,GO:0042221,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0046688,GO:0046872,GO:0046914,GO:0050896,GO:0051259,GO:0051260,GO:0065003,GO:0071840 4.2.3.1 ko:K01733,ko:K03926 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0UM@40117,COG1324@1,COG1324@2 NA|NA|NA P CutA1 divalent ion tolerance protein PFHLONEA_01394 316067.Geob_1869 1.2e-73 284.6 Desulfuromonadales lptD GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0008643,GO:0008645,GO:0009279,GO:0015267,GO:0015288,GO:0015749,GO:0015750,GO:0015751,GO:0015757,GO:0016020,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0030312,GO:0030313,GO:0031975,GO:0034219,GO:0044462,GO:0044464,GO:0046323,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:1904659 ko:K04744,ko:K09774,ko:K22110 ko00000,ko02000 1.B.35.1,1.B.35.2,1.B.42.1 iAF987.Gmet_2474,iECO111_1330.ECO111_4695,iECSF_1327.ECSF_3725,iEcSMS35_1347.EcSMS35_4260 Bacteria 1MUJC@1224,2WJUD@28221,42N34@68525,43TYF@69541,COG1452@1,COG1452@2 NA|NA|NA M Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane PFHLONEA_01395 1121405.dsmv_2185 9.7e-93 347.4 Desulfobacterales folC GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 iLJ478.TM0166,iSB619.SA_RS08370 Bacteria 1MVCH@1224,2MHTY@213118,2WIW9@28221,42N08@68525,COG0285@1,COG0285@2 NA|NA|NA H Mur ligase middle domain PFHLONEA_01398 243231.GSU2923 1.3e-81 309.7 Desulfuromonadales murI GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008881,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0030203,GO:0034645,GO:0036361,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0047661,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 R00260 RC00302 ko00000,ko00001,ko01000,ko01011 iAF987.Gmet_0547 Bacteria 1NAI2@1224,2WKYK@28221,42P58@68525,43TAQ@69541,COG0796@1,COG0796@2 NA|NA|NA M Provides the (R)-glutamate required for cell wall biosynthesis PFHLONEA_01399 96561.Dole_1616 2.2e-12 79.3 Desulfobacterales Bacteria 1NA0G@1224,2MKUK@213118,2WRCV@28221,42V1V@68525,COG5401@1,COG5401@2 NA|NA|NA S Sporulation and spore germination PFHLONEA_01400 289376.THEYE_A1467 1.6e-12 80.1 Nitrospirae amiA 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 Bacteria 3J0MT@40117,COG0860@1,COG0860@2 NA|NA|NA M Ami_3 PFHLONEA_01401 215803.DB30_2329 6.4e-117 428.7 Deltaproteobacteria lolE-2 ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 1NR2V@1224,2WUNG@28221,42YIK@68525,COG0577@1,COG0577@2,COG4591@1,COG4591@2 NA|NA|NA MV MacB-like periplasmic core domain PFHLONEA_01402 632335.Calkr_2381 2.2e-64 252.3 Thermoanaerobacterales macB ko:K02003 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 1TPBJ@1239,248EZ@186801,42G06@68295,COG1136@1,COG1136@2 NA|NA|NA P Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides PFHLONEA_01403 589865.DaAHT2_1314 4.2e-77 294.3 Desulfobacterales Bacteria 1RAK6@1224,2MJW8@213118,2WN2M@28221,42QS5@68525,COG0655@1,COG0655@2 NA|NA|NA S PFAM NADPH-dependent FMN reductase PFHLONEA_01404 1121430.JMLG01000006_gene1765 2.2e-59 235.3 Peptococcaceae pyrR GO:0003674,GO:0003700,GO:0003824,GO:0004845,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006220,GO:0006221,GO:0006355,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0031323,GO:0031326,GO:0034641,GO:0034654,GO:0043094,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046390,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0055086,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0080090,GO:0090407,GO:0140110,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141 2.4.2.9 ko:K02825 ko00240,ko01100,map00240,map01100 R00966 RC00063 ko00000,ko00001,ko01000,ko03000 Bacteria 1V3GV@1239,24FQD@186801,261GH@186807,COG2065@1,COG2065@2 NA|NA|NA F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant PFHLONEA_01405 338963.Pcar_1615 7.6e-113 413.7 Desulfuromonadales pyrB GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 ko:K00608,ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 iYO844.BSU15490 Bacteria 1MWAB@1224,2WJQR@28221,42NMR@68525,43S21@69541,COG0540@1,COG0540@2 NA|NA|NA F Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain PFHLONEA_01406 330214.NIDE2540 3.8e-155 554.7 Nitrospirae pyrC GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0D7@40117,COG0044@1,COG0044@2 NA|NA|NA F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily PFHLONEA_01407 909663.KI867150_gene2122 1.1e-39 170.6 Bacteria Bacteria COG1409@1,COG1409@2 NA|NA|NA S acid phosphatase activity PFHLONEA_01408 404380.Gbem_1898 4.1e-153 547.7 Desulfuromonadales carA GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1383 Bacteria 1MUB9@1224,2WIQ5@28221,42KZG@68525,43TE7@69541,COG0505@1,COG0505@2 NA|NA|NA F TIGRFAM carbamoyl-phosphate synthase, small subunit PFHLONEA_01409 243231.GSU1274 2.4e-95 355.5 Desulfuromonadales 1.97.1.4 ko:K04070 ko00000,ko01000 Bacteria 1NZAK@1224,2WIT2@28221,42NYF@68525,43SFJ@69541,COG1313@1,COG1313@2 NA|NA|NA C radical SAM domain protein PFHLONEA_01410 56780.SYN_01994 2.1e-27 128.6 Syntrophobacterales macB ko:K02003 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 1MU45@1224,2MQA4@213462,2WJE9@28221,42P96@68525,COG1136@1,COG1136@2 NA|NA|NA V ABC transporter PFHLONEA_01411 56780.SYN_01995 1.2e-169 602.8 Deltaproteobacteria salY ko:K02004,ko:K05685 ko02010,map02010 M00258,M00709 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.122.1,3.A.1.122.12 Bacteria 1PBKH@1224,2WJEU@28221,42MAR@68525,COG0577@1,COG0577@2 NA|NA|NA V ABC-type antimicrobial peptide transport system, permease component PFHLONEA_01414 760568.Desku_0058 2.2e-99 369.0 Peptococcaceae 2.1.1.86 ko:K00584 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00357,M00567 R04347 RC00035,RC00113,RC02892 ko00000,ko00001,ko00002,ko01000 Bacteria 1UYYD@1239,24AC2@186801,26150@186807,COG1962@1,COG1962@2 NA|NA|NA H Tetrahydromethanopterin S-methyltransferase MtrH subunit PFHLONEA_01415 589924.Ferp_1757 5e-37 161.0 Archaea Archaea COG0599@1,arCOG02148@2157 NA|NA|NA S PFAM Carboxymuconolactone decarboxylase PFHLONEA_01416 1205680.CAKO01000004_gene3674 3.9e-44 184.5 Proteobacteria ko:K01998 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 1NU5I@1224,COG4177@1,COG4177@2 NA|NA|NA E Branched-chain amino acid transport system / permease component PFHLONEA_01418 497964.CfE428DRAFT_0438 5.6e-12 77.4 Bacteria ko:K20274 ko02024,map02024 ko00000,ko00001,ko01002 Bacteria COG1520@1,COG1520@2,COG1572@1,COG1572@2,COG3227@1,COG3227@2,COG3391@1,COG3391@2,COG4782@1,COG4782@2 NA|NA|NA P Protein conserved in bacteria PFHLONEA_01420 102129.Lepto7375DRAFT_1533 1.3e-32 146.0 Cyanobacteria Bacteria 1G9Y9@1117,2ETWY@1,32VZU@2 NA|NA|NA PFHLONEA_01421 323261.Noc_1459 0.0 1102.8 Chromatiales 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 iAF987.Gmet_0348 Bacteria 1MV86@1224,1SYTD@1236,1X2IM@135613,COG0265@1,COG0265@2,COG0308@1,COG0308@2,COG2234@1,COG2234@2 NA|NA|NA EO Peptidase family M28 PFHLONEA_01422 1123284.KB899042_gene1365 6.8e-45 188.3 Sporolactobacillaceae 1.6.99.3 ko:K03885 ko00190,map00190 ko00000,ko00001,ko01000 Bacteria 1TR6X@1239,26NY8@186821,4HA14@91061,COG1252@1,COG1252@2 NA|NA|NA C Pyridine nucleotide-disulphide oxidoreductase PFHLONEA_01423 289376.THEYE_A0511 3e-22 111.3 Bacteria Bacteria COG1504@1,COG1504@2 NA|NA|NA L Protein of unknown function (DUF498/DUF598) PFHLONEA_01425 1255043.TVNIR_3349 1.9e-96 359.4 Proteobacteria Bacteria 1N3RW@1224,COG1085@1,COG1085@2 NA|NA|NA C galactose-1-phosphate uridylyltransferase PFHLONEA_01426 1089553.Tph_c09580 8e-49 200.7 Thermoanaerobacterales Bacteria 1UYWK@1239,25DVG@186801,42IP1@68295,COG0639@1,COG0639@2 NA|NA|NA T Calcineurin-like phosphoesterase superfamily domain PFHLONEA_01428 1232410.KI421424_gene1667 3.6e-49 202.6 Deltaproteobacteria Bacteria 1QGH3@1224,28HEC@1,2WT75@28221,2Z7QS@2,42WU7@68525 NA|NA|NA PFHLONEA_01431 96561.Dole_1741 7.9e-40 171.0 Desulfobacterales Bacteria 1REEI@1224,2MMKQ@213118,2WNS4@28221,42RTM@68525,COG2199@1,COG2203@1,COG2203@2,COG3706@2 NA|NA|NA T PFAM GGDEF domain containing protein PFHLONEA_01432 1121430.JMLG01000007_gene2531 1.1e-09 68.6 Clostridia mobB GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 2.10.1.1,2.7.7.77 ko:K03750,ko:K03753,ko:K13818 ko00790,ko01100,map00790,map01100 R09735,R11581 RC03462 ko00000,ko00001,ko01000 iB21_1397.B21_03691,iBWG_1329.BWG_3527,iECBD_1354.ECBD_4174,iECDH1ME8569_1439.ECDH1ME8569_3728,iEcDH1_1363.EcDH1_4130,iJO1366.b3856,iSbBS512_1146.SbBS512_E4328,iY75_1357.Y75_RS17805 Bacteria 1UMSA@1239,25GPP@186801,COG1763@1,COG1763@2 NA|NA|NA H Mo-molybdopterin cofactor biosynthetic process PFHLONEA_01433 453591.Igni_0911 3e-61 242.3 Crenarchaeota trxB 1.8.1.9 ko:K00384,ko:K03387 ko00450,map00450 R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 Archaea 2XPSW@28889,COG0492@1,arCOG01296@2157 NA|NA|NA C FAD-dependent pyridine nucleotide-disulphide oxidoreductase PFHLONEA_01434 289376.THEYE_A0361 6.9e-104 384.4 Nitrospirae moeA 2.10.1.1 ko:K03750,ko:K07219 ko00790,ko01100,map00790,map01100 R09735 RC03462 ko00000,ko00001,ko01000 Bacteria 3J0MX@40117,COG0303@1,COG0303@2 NA|NA|NA H Probable molybdopterin binding domain PFHLONEA_01435 370438.PTH_2616 4.6e-205 721.1 Peptococcaceae MA20_10225 2.10.1.1 ko:K03750,ko:K07219 ko00790,ko01100,map00790,map01100 R09735 RC03462 ko00000,ko00001,ko01000 Bacteria 1TRH3@1239,24ATZ@186801,2612F@186807,COG0303@1,COG0303@2,COG1910@1,COG1910@2 NA|NA|NA HP TIGRFAM molybdenum cofactor synthesis PFHLONEA_01436 671143.DAMO_0494 2.1e-41 176.0 unclassified Bacteria tolQ ko:K03561,ko:K03562 ko01120,map01120 ko00000,ko02000 1.A.30.2.1,1.A.30.2.2 Bacteria 2NPFR@2323,COG0811@1,COG0811@2 NA|NA|NA U MotA/TolQ/ExbB proton channel family PFHLONEA_01437 330214.NIDE3362 3.3e-31 141.4 Nitrospirae tolR ko:K03559,ko:K03560 ko00000,ko02000 1.A.30.2.1,1.A.30.2.2 Bacteria 3J0T6@40117,COG0848@1,COG0848@2 NA|NA|NA U Biopolymer transport protein ExbD/TolR PFHLONEA_01439 671143.DAMO_0497 2.5e-29 136.7 unclassified Bacteria tolB GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0009719,GO:0009987,GO:0010033,GO:0010243,GO:0015031,GO:0015833,GO:0015893,GO:0017038,GO:0019534,GO:0019904,GO:0022857,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0032991,GO:0033036,GO:0042221,GO:0042493,GO:0042597,GO:0042886,GO:0042891,GO:0043213,GO:0044464,GO:0044877,GO:0045184,GO:0046677,GO:0046678,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0070887,GO:0071236,GO:0071237,GO:0071310,GO:0071417,GO:0071495,GO:0071702,GO:0071705,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1901998 ko:K03641 ko00000,ko02000 2.C.1.2 Bacteria 2NNZC@2323,COG0823@1,COG0823@2 NA|NA|NA U TolB amino-terminal domain PFHLONEA_01440 269799.Gmet_2409 5.4e-63 247.3 Desulfuromonadales 3.5.1.124 ko:K05520 ko00000,ko01000,ko01002 Bacteria 1MY0C@1224,2WPE1@28221,42SWA@68525,43W0S@69541,COG0693@1,COG0693@2 NA|NA|NA S DJ-1/PfpI family PFHLONEA_01442 909663.KI867150_gene54 6.5e-215 753.8 Syntrophobacterales yyaL ko:K06888 ko00000 Bacteria 1MUUT@1224,2MQ5N@213462,2WJ7Y@28221,42MP3@68525,COG1331@1,COG1331@2 NA|NA|NA O Protein of unknown function, DUF255 PFHLONEA_01443 335543.Sfum_2837 5.8e-118 431.8 Syntrophobacterales Bacteria 1RCM9@1224,2MQRX@213462,2X7QC@28221,42QA2@68525,COG4191@1,COG4191@2,COG4251@1,COG4251@2 NA|NA|NA T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PFHLONEA_01444 370438.PTH_0131 1.3e-91 343.2 Peptococcaceae Bacteria 1TPZ4@1239,249UR@186801,2606I@186807,COG0535@1,COG0535@2 NA|NA|NA S Protein of unknown function (DUF3641) PFHLONEA_01445 1382358.JHVN01000015_gene614 4.2e-23 115.5 Bacilli Bacteria 1UHFB@1239,4HCQT@91061,COG4244@1,COG4244@2 NA|NA|NA S Membrane PFHLONEA_01446 941449.dsx2_2407 4.5e-69 267.7 Desulfovibrionales ko:K07025 ko00000 Bacteria 1Q4QT@1224,2MGMT@213115,2WUXD@28221,42ZNN@68525,COG1011@1,COG1011@2 NA|NA|NA S Haloacid dehalogenase-like hydrolase PFHLONEA_01447 399550.Smar_0766 2.7e-33 148.3 Archaea 1.16.3.1 ko:K03594 ko00860,map00860 R00078 RC02758 ko00000,ko00001,ko01000 Archaea COG2193@1,arCOG01094@2157 NA|NA|NA P Ferritin-like domain PFHLONEA_01448 1304888.ATWF01000001_gene2190 8.9e-30 136.7 Deferribacteres usp-2 ko:K06149 ko00000 Bacteria 2GFI3@200930,COG0589@1,COG0589@2 NA|NA|NA T Universal stress protein family PFHLONEA_01453 1121422.AUMW01000023_gene2749 1.2e-57 229.9 Peptococcaceae bioD GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.3 ko:K01935 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03182 RC00868 ko00000,ko00001,ko00002,ko01000 Bacteria 1UYA3@1239,24F15@186801,26262@186807,COG0132@1,COG0132@2 NA|NA|NA H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring PFHLONEA_01454 443143.GM18_3952 3e-14 85.1 Bacteria shp 1.11.1.5 ko:K00428 ko00000,ko01000 Bacteria COG1858@1,COG1858@2 NA|NA|NA C electron transfer activity PFHLONEA_01456 237368.SCABRO_00633 3.9e-194 684.5 Planctomycetes hycE Bacteria 2IZ46@203682,COG3261@1,COG3261@2 NA|NA|NA C Respiratory-chain NADH dehydrogenase, 30 Kd subunit PFHLONEA_01457 237368.SCABRO_00632 1.5e-134 486.5 Planctomycetes hyfF GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0033554,GO:0044425,GO:0044464,GO:0050896,GO:0051716,GO:0071944 ko:K12141 ko00000,ko01000 iECIAI39_1322.ECIAI39_2625,iZ_1308.Z3746 Bacteria 2IYC5@203682,COG0651@1,COG0651@2 NA|NA|NA CP Proton-conducting membrane transporter PFHLONEA_01458 1121405.dsmv_3266 2e-62 246.1 Desulfobacterales Bacteria 1MV5G@1224,2MHW1@213118,2WJG9@28221,42MPT@68525,COG1032@1,COG1032@2,COG5011@1,COG5011@2 NA|NA|NA C SMART Elongator protein 3 MiaB NifB PFHLONEA_01460 289376.THEYE_A1019 2.3e-121 442.2 Nitrospirae hypD ko:K04654 ko00000 iAF987.Gmet_0117 Bacteria 3J0W7@40117,COG0409@1,COG0409@2 NA|NA|NA O Hydrogenase formation hypA family PFHLONEA_01462 1121423.JONT01000013_gene345 1.6e-53 216.5 Peptococcaceae pyrK ko:K02823 ko00240,ko01100,map00240,map01100 ko00000,ko00001 Bacteria 1TQ5D@1239,24AY2@186801,261I3@186807,COG0543@1,COG0543@2 NA|NA|NA C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) PFHLONEA_01463 289376.THEYE_A0541 1.4e-41 176.0 Nitrospirae greA GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006354,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0030312,GO:0031323,GO:0031326,GO:0032774,GO:0032784,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 ko:K03624 ko00000,ko03021 Bacteria 3J0NA@40117,COG0782@1,COG0782@2 NA|NA|NA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides PFHLONEA_01464 1125863.JAFN01000001_gene353 8.3e-234 816.6 Deltaproteobacteria carB GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 iAF1260.b0033,iBWG_1329.BWG_0031,iECDH10B_1368.ECDH10B_0034,iECDH1ME8569_1439.ECDH1ME8569_0031,iECUMN_1333.ECUMN_0034,iEcDH1_1363.EcDH1_3566,iJN746.PP_4723,iJO1366.b0033,iJR904.b0033,iPC815.YPO0482,iY75_1357.Y75_RS00170,iYL1228.KPN_00041 Bacteria 1MUDZ@1224,2WJQH@28221,42MGK@68525,COG0458@1,COG0458@2 NA|NA|NA F Belongs to the CarB family PFHLONEA_01467 592015.HMPREF1705_02120 3e-61 241.5 Synergistetes tpx 1.11.1.15 ko:K11065 ko00000,ko01000 Bacteria 3TAX1@508458,COG2077@1,COG2077@2 NA|NA|NA O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides PFHLONEA_01468 909663.KI867150_gene187 3.5e-23 113.6 Syntrophobacterales cspA ko:K03704 ko00000,ko03000 Bacteria 1N6Q5@1224,2MS84@213462,2WR92@28221,42V0K@68525,COG1278@1,COG1278@2 NA|NA|NA K SMART Cold shock protein PFHLONEA_01469 309807.SRU_1312 1.5e-67 264.2 Bacteroidetes Order II. Incertae sedis pepF ko:K08602 ko00000,ko01000,ko01002 Bacteria 1FIWW@1100069,4NFYH@976,COG1164@1,COG1164@2 NA|NA|NA E Oligopeptidase F PFHLONEA_01470 269799.Gmet_0515 1.6e-64 252.7 Deltaproteobacteria 2.5.1.105 ko:K04088,ko:K06897 ko00790,map00790 M00742 R10339 RC00121 ko00000,ko00001,ko00002,ko01000 Bacteria 1ND3V@1224,2WWYS@28221,431R3@68525,COG0053@1,COG0053@2 NA|NA|NA P Cation efflux family PFHLONEA_01472 243231.GSU3268 5.8e-308 1063.1 Desulfuromonadales feoB ko:K04759 ko00000,ko02000 9.A.8.1 Bacteria 1MUZC@1224,2WIWJ@28221,42MCY@68525,43UAC@69541,COG0370@1,COG0370@2 NA|NA|NA P transporter of a GTP-driven Fe(2 ) uptake system PFHLONEA_01473 243231.GSU3269 1.3e-26 125.2 Desulfuromonadales feoA ko:K03709,ko:K04758 ko00000,ko02000,ko03000 Bacteria 1Q29B@1224,2WS7A@28221,42VSV@68525,43VT4@69541,COG1918@1,COG1918@2 NA|NA|NA P PFAM FeoA family protein PFHLONEA_01474 161156.JQKW01000006_gene1184 8.9e-15 85.9 Bacteria ko:K04758 ko00000,ko02000 Bacteria COG1918@1,COG1918@2 NA|NA|NA P iron ion homeostasis PFHLONEA_01475 1125863.JAFN01000001_gene2794 3.4e-39 167.9 Deltaproteobacteria petB Bacteria 1MV97@1224,2WMNX@28221,42MD6@68525,COG1290@1,COG1290@2 NA|NA|NA C PFAM Cytochrome b b6 domain PFHLONEA_01476 1125863.JAFN01000001_gene2793 3e-76 292.7 Deltaproteobacteria qcrC GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005507,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006464,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016667,GO:0016669,GO:0016740,GO:0016782,GO:0016783,GO:0018192,GO:0018193,GO:0018198,GO:0018307,GO:0019417,GO:0019538,GO:0020037,GO:0022900,GO:0031224,GO:0031226,GO:0036211,GO:0040007,GO:0042597,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046906,GO:0046914,GO:0046982,GO:0046983,GO:0048037,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:0098822,GO:1901363,GO:1901564 1.8.2.2 ko:K00406,ko:K03889,ko:K17222,ko:K19713 ko00190,ko00920,ko01100,ko01120,ko02020,map00190,map00920,map01100,map01120,map02020 M00151,M00156,M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002,ko01000 3.D.4.3 Bacteria 1RJJ2@1224,2WPS4@28221,42SCM@68525,COG2010@1,COG2010@2,COG3258@1,COG3258@2 NA|NA|NA C Cytochrome c PFHLONEA_01477 1379698.RBG1_1C00001G0011 1.6e-42 179.9 unclassified Bacteria narJ GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016530,GO:0022607,GO:0034622,GO:0042126,GO:0042128,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0051131,GO:0065003,GO:0071704,GO:0071840,GO:0071941,GO:0140104,GO:2001057 ko:K00373,ko:K00405,ko:K17052 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 ko00000,ko00001,ko00002,ko02000 3.D.4.3,5.A.3.8 iE2348C_1286.E2348C_1350,iECABU_c1320.ECABU_c15020,iECIAI1_1343.ECIAI1_1469,iECO103_1326.ECO103_1331,iECO111_1330.ECO111_1557,iECW_1372.ECW_m1594,iEKO11_1354.EKO11_2354,iLF82_1304.LF82_1462,iNRG857_1313.NRG857_06280,iSSON_1240.SSON_1659,iWFL_1372.ECW_m1594,ic_1306.c1687 Bacteria 2NR8D@2323,COG2010@1,COG2010@2,COG2180@1,COG2180@2 NA|NA|NA C Cytochrome c PFHLONEA_01478 436114.SYO3AOP1_0161 1.5e-45 189.9 Aquificae moxG ko:K00406,ko:K16255 ko00190,ko00680,ko01100,ko01120,ko02020,map00190,map00680,map01100,map01120,map02020 M00156 ko00000,ko00001,ko00002 3.D.4.3 Bacteria 2G55S@200783,COG2010@1,COG2010@2 NA|NA|NA C Cytochrome c class I PFHLONEA_01479 1255043.TVNIR_1638 1.5e-181 642.9 Chromatiales nosZ GO:0000041,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0008150,GO:0015677,GO:0030001,GO:0042597,GO:0044464,GO:0051179,GO:0051234 1.7.2.4,1.9.3.1 ko:K00376,ko:K02275 ko00190,ko00910,ko01100,ko01120,map00190,map00910,map01100,map01120 M00155,M00529 R00081,R02804 RC00016,RC02861 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 Bacteria 1MVIH@1224,1RQSW@1236,1WZYX@135613,COG4263@1,COG4263@2 NA|NA|NA C Cytochrome c oxidase subunit PFHLONEA_01480 305700.B447_07709 1.8e-57 229.9 Rhodocyclales nosR ko:K19339 ko00000,ko03000 Bacteria 1MY5M@1224,2KXJC@206389,2VH7V@28216,COG0348@1,COG0348@2,COG3901@1,COG3901@2 NA|NA|NA C 4Fe-4S binding domain PFHLONEA_01481 62928.azo3125 8.1e-26 122.9 Rhodocyclales Bacteria 1NDV6@1224,28JUM@1,2KWGF@206389,2VJ3P@28216,2Z9JN@2 NA|NA|NA PFHLONEA_01482 1123367.C666_09885 2.5e-27 128.6 Rhodocyclales Bacteria 1NDV6@1224,28JUM@1,2KWGF@206389,2VJ3P@28216,2Z9JN@2 NA|NA|NA PFHLONEA_01486 555779.Dthio_PD3237 5.9e-40 170.6 Desulfovibrionales bamG 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 1MWS2@1224,2M7XW@213115,2WPP9@28221,42SED@68525,COG1905@1,COG1905@2 NA|NA|NA C PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit PFHLONEA_01487 330214.NIDE1796 1.9e-138 499.2 Nitrospirae glgC GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008878,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0070566,GO:0071704,GO:1901576 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0BI@40117,COG0448@1,COG0448@2 NA|NA|NA H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans PFHLONEA_01488 1131269.AQVV01000016_gene1868 5.1e-22 110.9 Bacteria 2.7.7.80,2.8.1.11,3.13.1.6 ko:K21140,ko:K21147 ko04122,map04122 R07459,R07461,R11524 RC00043,RC00064,RC00090 ko00000,ko00001,ko01000 Bacteria COG1310@1,COG1310@2 NA|NA|NA S proteolysis PFHLONEA_01489 56780.SYN_02760 0.0 1125.2 Syntrophobacterales mgtA 3.6.3.2 ko:K01531 ko00000,ko01000 3.A.3.4 Bacteria 1MUU5@1224,2MQU9@213462,2WIU0@28221,42M8F@68525,COG0474@1,COG0474@2 NA|NA|NA P Cation transporter/ATPase, N-terminus PFHLONEA_01490 862908.BMS_0545 4.6e-14 84.3 Bdellovibrionales Bacteria 1N7GY@1224,2E6J8@1,2MU5V@213481,2WRHG@28221,3316B@2,42V6W@68525 NA|NA|NA PFHLONEA_01493 1123009.AUID01000001_gene1054 9e-28 130.6 unclassified Clostridiales rnfB 1.8.99.2 ko:K00395,ko:K02572,ko:K02573,ko:K02574,ko:K03616 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00596 R00860,R04927,R08553 RC00007,RC01239,RC02862 ko00000,ko00001,ko00002,ko01000 Bacteria 1TQGD@1239,24904@186801,268S4@186813,COG1245@1,COG1245@2,COG2878@1,COG2878@2 NA|NA|NA C Putative Fe-S cluster PFHLONEA_01494 289376.THEYE_A1007 2e-38 165.2 Nitrospirae gcvH ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 Bacteria 3J0SD@40117,COG0509@1,COG0509@2 NA|NA|NA E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein PFHLONEA_01497 909663.KI867150_gene187 8.4e-20 102.4 Syntrophobacterales cspA ko:K03704 ko00000,ko03000 Bacteria 1N6Q5@1224,2MS84@213462,2WR92@28221,42V0K@68525,COG1278@1,COG1278@2 NA|NA|NA K SMART Cold shock protein PFHLONEA_01498 211114.JOEF01000003_gene2828 1.5e-09 70.1 Pseudonocardiales cwlM GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 3.2.1.17,3.5.1.28 ko:K01185,ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 Bacteria 2GPA9@201174,4E10H@85010,COG0860@1,COG0860@2,COG3409@1,COG3409@2 NA|NA|NA M N-acetylmuramoyl-L-alanine amidase PFHLONEA_01500 1094508.Tsac_0605 7.7e-70 270.8 Thermoanaerobacterales 4.1.99.14 ko:K03716 ko00000,ko01000 Bacteria 1TQA6@1239,24A2T@186801,42F9K@68295,COG1533@1,COG1533@2 NA|NA|NA L Domain of unknown function (DUF1848) PFHLONEA_01501 177439.DP2959 1.1e-41 176.4 Desulfobacterales ko:K03719 ko00000,ko03000,ko03036 Bacteria 1MXVU@1224,2MK1J@213118,2WNB1@28221,42S5E@68525,COG1522@1,COG1522@2 NA|NA|NA K helix_turn_helix ASNC type PFHLONEA_01504 1125863.JAFN01000001_gene972 1.2e-34 153.7 Deltaproteobacteria motB ko:K02557 ko02030,ko02040,map02030,map02040 ko00000,ko00001,ko02000,ko02035 1.A.30.1 Bacteria 1MU4S@1224,2WPPV@28221,42T2J@68525,COG1360@1,COG1360@2 NA|NA|NA N PFAM OmpA MotB domain protein PFHLONEA_01506 696369.KI912183_gene214 4.3e-18 97.1 Peptococcaceae hpt 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 Bacteria 1V1C9@1239,24FR4@186801,261JF@186807,COG0634@1,COG0634@2 NA|NA|NA F Belongs to the purine pyrimidine phosphoribosyltransferase family PFHLONEA_01507 880073.Calab_3603 2.2e-18 99.4 Bacteria 2.1.1.334 ko:K21310 ko00920,map00920 R11546 RC02653 ko00000,ko00001,ko01000 Bacteria COG2020@1,COG2020@2 NA|NA|NA O methyltransferase activity PFHLONEA_01508 517417.Cpar_0120 6.1e-78 298.5 Chlorobi nagA 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 Bacteria 1FDM0@1090,COG1472@1,COG1472@2 NA|NA|NA G PFAM glycoside hydrolase, family 3 domain protein PFHLONEA_01509 1191523.MROS_0856 4.2e-33 147.9 Bacteria ko:K03976,ko:K19055 ko00000,ko01000,ko03016 Bacteria COG2606@1,COG2606@2 NA|NA|NA S Cys-tRNA(Pro) hydrolase activity PFHLONEA_01510 595460.RRSWK_05290 2e-80 305.8 Bacteria 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria COG0204@1,COG0204@2 NA|NA|NA I Acyl-transferase PFHLONEA_01511 909663.KI867150_gene711 3.7e-72 278.1 Syntrophobacterales 5.2.1.8 ko:K01802,ko:K03773 ko00000,ko01000,ko03110 Bacteria 1RDA1@1224,2MS4J@213462,2X21K@28221,43A29@68525,COG0545@1,COG0545@2 NA|NA|NA M FKBP-type peptidyl-prolyl cis-trans isomerase PFHLONEA_01512 1267533.KB906747_gene24 4.2e-36 157.5 Bacteria nuoA GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria COG0838@1,COG0838@2 NA|NA|NA C NADH dehydrogenase (ubiquinone) activity PFHLONEA_01513 629265.PMA4326_07916 2.9e-59 235.0 Pseudomonas syringae group 3.4.22.38 ko:K01371 ko04142,ko04210,ko04380,ko04620,ko05323,map04142,map04210,map04380,map04620,map05323 ko00000,ko00001,ko01000,ko01002,ko03110 Bacteria 1MV6S@1224,1S02V@1236,1Z6BR@136849,COG4870@1,COG4870@2 NA|NA|NA O Papain cysteine protease family protein PFHLONEA_01514 1144310.PMI07_006565 4e-98 364.8 Proteobacteria Bacteria 1NE5Q@1224,COG3291@1,COG3291@2 NA|NA|NA O Pregnancy-associated plasma protein-A PFHLONEA_01515 1173024.KI912151_gene2020 2.5e-18 98.2 Bacteria Bacteria 2E8HZ@1,332W1@2 NA|NA|NA PFHLONEA_01518 96561.Dole_2567 2.3e-20 105.5 Desulfobacterales Bacteria 1NA8U@1224,2EBR1@1,2MP89@213118,2WRH5@28221,335QY@2,42W3V@68525 NA|NA|NA PFHLONEA_01519 330214.NIDE3826 1.6e-303 1048.5 Nitrospirae Bacteria 3J0XX@40117,COG1924@1,COG1924@2,COG3580@1,COG3580@2,COG3581@1,COG3581@2 NA|NA|NA I CoA enzyme activase uncharacterised domain (DUF2229) PFHLONEA_01520 330214.NIDE0419 4.8e-89 334.3 Nitrospirae pheA GO:0003674,GO:0003824,GO:0004106,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 1.3.1.12,2.3.1.79,4.2.1.51,4.2.1.91,5.4.99.5 ko:K00661,ko:K01713,ko:K04092,ko:K04093,ko:K04516,ko:K04518,ko:K14170,ko:K14187 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715,R01728 RC00125,RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 iECNA114_1301.ECNA114_2667 Bacteria 3J0A9@40117,COG0077@1,COG0077@2,COG1605@1,COG1605@2 NA|NA|NA E Chorismate mutase type II PFHLONEA_01521 330214.NIDE0420 9.2e-102 377.1 Nitrospirae hisC 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 3J0XY@40117,COG0079@1,COG0079@2 NA|NA|NA E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily PFHLONEA_01522 330214.NIDE0421 8e-124 450.3 Nitrospirae aroF 2.5.1.54 ko:K03856 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0A5@40117,COG2876@1,COG2876@2 NA|NA|NA E NeuB family PFHLONEA_01523 717231.Flexsi_2029 3e-131 474.9 Deferribacteres glyQ GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016874,GO:0016875,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0140098,GO:0140101 6.1.1.14 ko:K01878,ko:K14164 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iAF1260.b3560,iAF987.Gmet_2942,iJO1366.b3560,iPC815.YPO4072,iY75_1357.Y75_RS19360 Bacteria 2GEZ4@200930,COG0752@1,COG0752@2 NA|NA|NA J Glycyl-tRNA synthetase alpha subunit PFHLONEA_01524 398767.Glov_1022 8.3e-176 624.0 Deltaproteobacteria glyS GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.14 ko:K01879,ko:K14164 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iAPECO1_1312.APECO1_2891,iE2348C_1286.E2348C_3810,iECABU_c1320.ECABU_c40010,iECED1_1282.ECED1_4242,iECH74115_1262.ECH74115_4934,iECNA114_1301.ECNA114_3710,iECOK1_1307.ECOK1_4005,iECP_1309.ECP_3661,iECS88_1305.ECS88_3976,iECSF_1327.ECSF_3393,iECSP_1301.ECSP_4554,iECs_1301.ECs4442,iG2583_1286.G2583_4300,iJN678.glyS,iUMN146_1321.UM146_17960,iUTI89_1310.UTI89_C4099,ic_1306.c4378 Bacteria 1MV2F@1224,2WJIT@28221,42M6A@68525,COG0751@1,COG0751@2 NA|NA|NA J Glycyl-tRNA synthetase beta subunit PFHLONEA_01525 1329516.JPST01000014_gene622 9.7e-71 273.5 Thermoactinomycetaceae gidA GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 ko:K03495 R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 Bacteria 1TQ4B@1239,27B0A@186824,4HA6S@91061,COG0445@1,COG0445@2 NA|NA|NA D GidA associated domain 3 PFHLONEA_01526 269799.Gmet_3558 2.7e-35 155.6 Desulfuromonadales rsmG GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 ko:K03501 ko00000,ko01000,ko03009,ko03036 Bacteria 1MY0K@1224,2WPKF@28221,42SB8@68525,43UZG@69541,COG0357@1,COG0357@2 NA|NA|NA J Specifically methylates the N7 position of guanine in position 527 of 16S rRNA PFHLONEA_01527 272844.PAB0124 2.2e-39 169.9 Thermococci GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019205,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0051731,GO:0071704,GO:0090304,GO:1901360 ko:K06947 ko00000,ko01000,ko03009 Archaea 243KY@183968,2XT4Z@28890,COG5623@1,arCOG04127@2157 NA|NA|NA A Polynucleotide kinase that can phosphorylate the 5'- hydroxyl groups of both single-stranded RNA (ssRNA) and single- stranded DNA (ssDNA). Exhibits a strong preference for ssRNA PFHLONEA_01528 1089550.ATTH01000001_gene2122 7.3e-85 320.5 Bacteroidetes Order II. Incertae sedis soj ko:K03496 ko00000,ko03036,ko04812 Bacteria 1FJ0J@1100069,4NFEX@976,COG1192@1,COG1192@2 NA|NA|NA D Cellulose biosynthesis protein BcsQ PFHLONEA_01529 555079.Toce_2275 6.1e-69 267.7 Thermoanaerobacterales parB ko:K03497 ko00000,ko03000,ko03036,ko04812 Bacteria 1TQ2B@1239,249VV@186801,42FPF@68295,COG1475@1,COG1475@2 NA|NA|NA K Belongs to the ParB family PFHLONEA_01530 502025.Hoch_6068 4.8e-24 117.5 Myxococcales Bacteria 1N7TF@1224,2WRPF@28221,2YVIX@29,42VWZ@68525,COG1664@1,COG1664@2 NA|NA|NA M Polymer-forming cytoskeletal PFHLONEA_01531 289376.THEYE_A0629 0.0 1667.5 Nitrospirae purL GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016884,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 iECH74115_1262.ECH74115_3792,iECO111_1330.ECO111_3283,iECSP_1301.ECSP_3501,iECs_1301.ECs3423,iG2583_1286.G2583_3088,iJN746.PP_1037,ic_1306.c3080 Bacteria 3J0TJ@40117,COG0046@1,COG0046@2,COG0047@1,COG0047@2 NA|NA|NA F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL PFHLONEA_01532 747365.Thena_1452 3.5e-14 84.7 Thermoanaerobacterales Bacteria 1V7U2@1239,24JE5@186801,42GI5@68295,COG4747@1,COG4747@2 NA|NA|NA S PFAM amino acid-binding ACT domain protein PFHLONEA_01533 330214.NIDE1002 1.2e-60 239.6 Nitrospirae leuA 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS10690,iYO844.BSU28280 Bacteria 3J0F7@40117,COG0119@1,COG0119@2 NA|NA|NA E Belongs to the alpha-IPM synthase homocitrate synthase family PFHLONEA_01534 289376.THEYE_A0867 4.6e-177 627.5 Nitrospirae leuC 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 3J0IH@40117,COG0065@1,COG0065@2 NA|NA|NA H Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate PFHLONEA_01535 1125863.JAFN01000001_gene2477 5.2e-68 263.8 Deltaproteobacteria leuD 1.1.1.85,4.2.1.33,4.2.1.35,4.2.1.85 ko:K00052,ko:K01704,ko:K20453 ko00290,ko00660,ko00760,ko01100,ko01110,ko01120,ko01210,ko01230,map00290,map00660,map00760,map01100,map01110,map01120,map01210,map01230 M00432,M00535 R00994,R03069,R03896,R03898,R03968,R04001,R04426,R10052,R10170 RC00084,RC00417,RC00843,RC00976,RC00977,RC01041,RC01046,RC03036,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1MVXB@1224,2X5ND@28221,42R6H@68525,COG0066@1,COG0066@2 NA|NA|NA E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate PFHLONEA_01536 665571.STHERM_c03940 4.1e-150 537.7 Bacteria leuB GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044464,GO:0055114 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria COG0473@1,COG0473@2 NA|NA|NA CE 3-isopropylmalate dehydrogenase activity PFHLONEA_01537 279714.FuraDRAFT_1689 1.8e-161 575.5 Neisseriales asd GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004073,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006553,GO:0006555,GO:0006566,GO:0006790,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009081,GO:0009082,GO:0009085,GO:0009086,GO:0009088,GO:0009089,GO:0009090,GO:0009092,GO:0009097,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0033554,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 iECP_1309.ECP_3527 Bacteria 1MUHG@1224,2KPMB@206351,2VH2N@28216,COG0136@1,COG0136@2 NA|NA|NA E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate PFHLONEA_01539 1449063.JMLS01000001_gene4153 1.5e-14 85.9 Paenibacillaceae erpA GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009061,GO:0009987,GO:0010467,GO:0015980,GO:0016020,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055114,GO:0071704,GO:0071840,GO:0071944,GO:1901564 ko:K13628,ko:K15724 ko00000,ko03016 Bacteria 1V6IN@1239,26Y3H@186822,4HKN2@91061,COG0316@1,COG0316@2 NA|NA|NA S Belongs to the HesB IscA family PFHLONEA_01540 335543.Sfum_3201 1e-170 606.7 Syntrophobacterales cobA GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 ko:K01719,ko:K02302,ko:K02303,ko:K13542 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03165,R03194,R03947 RC00003,RC00871,RC01012,RC01034,RC01861 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS15755,iYO844.BSU15610 Bacteria 1MUI0@1224,2MQX4@213462,2WIRJ@28221,42MCB@68525,COG0007@1,COG0007@2,COG1587@1,COG1587@2 NA|NA|NA H Belongs to the precorrin methyltransferase family PFHLONEA_01541 269799.Gmet_3234 2.5e-111 408.7 Desulfuromonadales hemC GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018065,GO:0018130,GO:0018160,GO:0018193,GO:0018198,GO:0019438,GO:0019538,GO:0033013,GO:0033014,GO:0034641,GO:0036211,GO:0042168,GO:0042440,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107,2.5.1.61,4.2.1.75 ko:K01749,ko:K13542 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084,R03165,R03194 RC00003,RC00871,RC01861,RC02317 ko00000,ko00001,ko00002,ko01000 iEC55989_1330.EC55989_4275,iECH74115_1262.ECH74115_5243,iECIAI1_1343.ECIAI1_3991,iECO103_1326.ECO103_4362,iECO111_1330.ECO111_4628,iECO26_1355.ECO26_4784,iECSE_1348.ECSE_4086,iEKO11_1354.EKO11_4554,iHN637.CLJU_RS15760,iPC815.YPO3849 Bacteria 1MU56@1224,2WJ5V@28221,42M84@68525,43T66@69541,COG0181@1,COG0181@2 NA|NA|NA H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps PFHLONEA_01542 1232410.KI421412_gene411 1.2e-119 436.8 Desulfuromonadales hemA GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040 1.2.1.70 ko:K02407,ko:K02492 ko00860,ko01100,ko01110,ko01120,ko02040,map00860,map01100,map01110,map01120,map02040 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000,ko02035 Bacteria 1MU41@1224,2WISB@28221,42MUG@68525,43SX3@69541,COG0373@1,COG0373@2 NA|NA|NA H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) PFHLONEA_01543 443143.GM18_3974 3.1e-70 271.9 Desulfuromonadales Bacteria 1RCCI@1224,2WJ7I@28221,42PVM@68525,43TXA@69541,COG0755@1,COG0755@2 NA|NA|NA O PFAM cytochrome c assembly protein PFHLONEA_01544 338966.Ppro_3016 7.4e-67 260.4 Desulfuromonadales lolD ko:K09810 ko02010,map02010 M00255 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.125 Bacteria 1MVSQ@1224,2WMSN@28221,42QNS@68525,43SYM@69541,COG1136@1,COG1136@2 NA|NA|NA V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner PFHLONEA_01546 316067.Geob_2095 2.6e-100 372.5 Desulfuromonadales lolC GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008104,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0034613,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0070727,GO:0071944,GO:0072657,GO:0089705,GO:0098796,GO:0098797,GO:1990778 ko:K02004,ko:K09808 ko02010,map02010 M00255,M00258 ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.125 Bacteria 1MVV7@1224,2WITK@28221,42MV0@68525,43T9B@69541,COG4591@1,COG4591@2 NA|NA|NA M TIGRFAM lipoprotein releasing system, transmembrane protein, LolC E family PFHLONEA_01547 289376.THEYE_A1233 1.2e-171 609.8 Nitrospirae lysS GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006518,GO:0006520,GO:0006629,GO:0006644,GO:0006650,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009059,GO:0009405,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019637,GO:0019752,GO:0030312,GO:0030322,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0040007,GO:0042221,GO:0042391,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046471,GO:0046483,GO:0046486,GO:0046677,GO:0046872,GO:0050896,GO:0051704,GO:0065007,GO:0065008,GO:0071704,GO:0071944,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iAF1260.b4129,iECDH1ME8569_1439.ECDH1ME8569_3989,iECW_1372.ECW_m4490,iEcDH1_1363.EcDH1_3862,iJN678.lysS,iJO1366.b4129,iWFL_1372.ECW_m4490 Bacteria 3J0AW@40117,COG1190@1,COG1190@2 NA|NA|NA J tRNA synthetases class II (D, K and N) PFHLONEA_01548 1121405.dsmv_2798 5.6e-105 387.5 Desulfobacterales purC GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6,6.3.4.13 ko:K01923,ko:K01945,ko:K03566 ko00230,ko01100,ko01110,ko01130,ko02026,map00230,map01100,map01110,map01130,map02026 M00048 R04144,R04591 RC00064,RC00090,RC00162,RC00166 ko00000,ko00001,ko00002,ko01000,ko03000 Bacteria 1MUR9@1224,2MI2P@213118,2WJY0@28221,42M8A@68525,COG0152@1,COG0152@2 NA|NA|NA F PFAM SAICAR synthetase PFHLONEA_01549 574087.Acear_0620 4.4e-62 245.0 Halanaerobiales tlyC ko:K03699,ko:K06189 ko00000,ko02000,ko02042 9.A.40.1.2 Bacteria 1TPN0@1239,2489N@186801,3WAE6@53433,COG1253@1,COG1253@2 NA|NA|NA S CBS domain PFHLONEA_01550 338966.Ppro_0392 2.1e-09 68.2 Desulfuromonadales XK27_07760 Bacteria 1NB49@1224,2WRVH@28221,42W0M@68525,43SQE@69541,COG4980@1,COG4980@2 NA|NA|NA S YtxH-like protein PFHLONEA_01551 1218075.BAYA01000004_gene1553 4.4e-15 88.6 Burkholderiaceae Bacteria 1KH7T@119060,1RHDD@1224,2VSDT@28216,COG0745@1,COG0745@2 NA|NA|NA T response regulator PFHLONEA_01552 880073.Calab_1678 1.2e-59 237.3 unclassified Bacteria Bacteria 2NPFQ@2323,COG0515@1,COG0515@2 NA|NA|NA KLT Serine threonine protein kinase PFHLONEA_01553 1278073.MYSTI_05913 5.2e-51 208.0 Deltaproteobacteria 3.1.3.16 ko:K01090,ko:K20074 ko00000,ko01000,ko01009 Bacteria 1R7UF@1224,2WP2A@28221,42QUA@68525,COG0631@1,COG0631@2 NA|NA|NA T protein phosphatase 2C domain protein PFHLONEA_01554 903818.KI912269_gene201 2.3e-52 212.6 Acidobacteria ko:K03455,ko:K07058 ko00000 2.A.37 Bacteria 3Y3RZ@57723,COG0664@1,COG0664@2,COG1295@1,COG1295@2 NA|NA|NA K Virulence factor BrkB PFHLONEA_01555 944481.JAFP01000001_gene254 1.5e-191 676.0 Desulfurellales ytcI GO:0003674,GO:0003824,GO:0003996,GO:0004321,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006633,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0015645,GO:0016053,GO:0016405,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0016874,GO:0016877,GO:0016878,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901576 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 1MUF5@1224,2M6V7@213113,2WJMC@28221,42P0M@68525,COG0365@1,COG0365@2 NA|NA|NA I AMP-binding enzyme C-terminal domain PFHLONEA_01556 269799.Gmet_0515 1.5e-65 256.1 Deltaproteobacteria 2.5.1.105 ko:K04088,ko:K06897 ko00790,map00790 M00742 R10339 RC00121 ko00000,ko00001,ko00002,ko01000 Bacteria 1ND3V@1224,2WWYS@28221,431R3@68525,COG0053@1,COG0053@2 NA|NA|NA P Cation efflux family PFHLONEA_01557 706587.Desti_3149 3.7e-34 151.8 Deltaproteobacteria 3.1.3.97 ko:K07053 R00188,R11188 RC00078 ko00000,ko01000 Bacteria 1RF04@1224,2WNC8@28221,42RR4@68525,COG0613@1,COG0613@2 NA|NA|NA S PFAM PHP domain PFHLONEA_01559 304371.MCP_1951 4.7e-16 91.3 Archaea Archaea arCOG11656@1,arCOG11656@2157 NA|NA|NA PFHLONEA_01561 419665.Maeo_0964 8e-10 70.1 Euryarchaeota ko:K07235,ko:K07236 ko04122,map04122 ko00000,ko00001,ko01000,ko03016 Archaea 2Y0VW@28890,COG1553@1,arCOG02068@2157 NA|NA|NA P DsrE/DsrF-like family PFHLONEA_01563 1487923.DP73_00805 4.4e-41 174.5 Peptococcaceae Bacteria 1VQ7W@1239,251NF@186801,265N8@186807,2CDHP@1,32RXU@2 NA|NA|NA S RsbT co-antagonist protein rsbRD N-terminal domain PFHLONEA_01564 913865.DOT_2386 2.1e-121 442.2 Peptococcaceae dsrM 1.7.5.1 ko:K00374 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000 5.A.3.1 Bacteria 1UYRK@1239,24FM8@186801,266ZT@186807,COG2181@1,COG2181@2 NA|NA|NA C PFAM Nitrate reductase gamma subunit PFHLONEA_01565 756499.Desde_0271 8.2e-264 916.0 Peptococcaceae dsrK Bacteria 1TSC1@1239,24B10@186801,260AF@186807,COG0247@1,COG0247@2 NA|NA|NA C 4Fe-4S dicluster domain PFHLONEA_01566 439235.Dalk_0841 4.2e-127 461.5 Desulfobacterales ko:K02843,ko:K02849 ko00540,ko01100,map00540,map01100 M00080 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 GT9 Bacteria 1PQIG@1224,2MN6W@213118,2WPZT@28221,42MUM@68525,COG0859@1,COG0859@2 NA|NA|NA M Glycosyltransferase family 9 (heptosyltransferase) PFHLONEA_01568 269799.Gmet_0887 4.4e-66 259.2 Desulfuromonadales arnT 2.4.2.43 ko:K07264 ko01503,map01503 M00721 R09773,R09774,R09781 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 Bacteria 1NMIZ@1224,2WNF1@28221,42RXF@68525,43TBY@69541,COG1807@1,COG1807@2 NA|NA|NA M PFAM glycosyl transferase family 39 PFHLONEA_01569 635013.TherJR_1410 3.4e-24 119.4 Bacteria mprF ko:K07027 ko00000,ko02000 4.D.2 Bacteria COG0392@1,COG0392@2 NA|NA|NA M lysyltransferase activity PFHLONEA_01570 1123376.AUIU01000014_gene680 8.8e-183 647.1 Nitrospirae valS GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iLJ478.TM1817 Bacteria 3J0B9@40117,COG0525@1,COG0525@2 NA|NA|NA J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner PFHLONEA_01571 720554.Clocl_4213 2.8e-82 312.0 Ruminococcaceae nadC GO:0003674,GO:0003824,GO:0004514,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016054,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034213,GO:0034641,GO:0034654,GO:0042737,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0072526,GO:0090407,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 1.4.3.16,2.4.2.19 ko:K00278,ko:K00767 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481,R03348 RC00006,RC02566,RC02877 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1988,iHN637.CLJU_RS12010,iLJ478.TM1645 Bacteria 1TPQC@1239,248P2@186801,3WGJ1@541000,COG0157@1,COG0157@2 NA|NA|NA H Belongs to the NadC ModD family PFHLONEA_01572 1449126.JQKL01000035_gene2179 4.6e-74 285.0 unclassified Clostridiales birA 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 Bacteria 1TQCU@1239,248CK@186801,2685H@186813,COG0340@1,COG0340@2 NA|NA|NA HK Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor PFHLONEA_01573 401526.TcarDRAFT_0920 1.8e-86 325.9 Negativicutes coaX GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1986 Bacteria 1TR0X@1239,4H2ZZ@909932,COG1521@1,COG1521@2 NA|NA|NA H Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis PFHLONEA_01574 338966.Ppro_0435 6.2e-29 133.7 Deltaproteobacteria 3.1.3.3 ko:K07315 ko00000,ko01000,ko03021 Bacteria 1RKC4@1224,2WPI1@28221,42SJ3@68525,COG2204@1,COG2204@2 NA|NA|NA T PFAM response regulator receiver PFHLONEA_01575 1162668.LFE_2206 2.1e-108 399.1 Nitrospirae galT 2.7.7.12 ko:K00965 ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917 M00362,M00554,M00632 R00955 RC00002 ko00000,ko00001,ko00002,ko01000 iLJ478.TM0896 Bacteria 3J0ER@40117,COG1085@1,COG1085@2 NA|NA|NA H Galactose-1-phosphate uridyl transferase, N-terminal domain PFHLONEA_01577 484770.UFO1_0827 6.4e-247 860.1 Negativicutes acnA 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2763 Bacteria 1VTMM@1239,4H2CQ@909932,COG1048@1,COG1048@2 NA|NA|NA C aconitate hydratase PFHLONEA_01578 880072.Desac_2444 1.1e-28 132.9 Syntrophobacterales ko:K03798 M00742 ko00000,ko00002,ko01000,ko01002,ko03110 Bacteria 1MU6J@1224,2MQ7P@213462,2WJZ3@28221,42M4Z@68525,COG0465@1,COG0465@2 NA|NA|NA O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins PFHLONEA_01579 1131269.AQVV01000011_gene2518 3.4e-207 728.4 Bacteria parC GO:0000819,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008150,GO:0008152,GO:0009330,GO:0009987,GO:0016020,GO:0016043,GO:0019897,GO:0019898,GO:0022402,GO:0030541,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0098813,GO:1901360,GO:1901363 5.99.1.3 ko:K02469,ko:K02621 ko00000,ko01000,ko02048,ko03032,ko03036,ko03400 Bacteria COG0188@1,COG0188@2 NA|NA|NA L DNA topoisomerase II activity PFHLONEA_01580 316067.Geob_1875 1e-195 689.9 Deltaproteobacteria 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 Bacteria 1MWBB@1224,2WK49@28221,42NR7@68525,COG2414@1,COG2414@2 NA|NA|NA C PFAM Aldehyde ferredoxin oxidoreductase PFHLONEA_01581 926561.KB900617_gene1659 2.1e-77 297.0 Halanaerobiales btuB ko:K02014,ko:K16089,ko:K16092 ko00000,ko02000 1.B.14,1.B.14.1,1.B.14.10,1.B.14.3 Bacteria 1V287@1239,24SUD@186801,3WB9E@53433,COG4206@1,COG4206@2 NA|NA|NA H TonB-dependent Receptor Plug PFHLONEA_01582 398767.Glov_3559 8.8e-46 190.7 Deltaproteobacteria 3.6.3.34 ko:K02013 ko02010,map02010 M00240 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 Bacteria 1QV5A@1224,2X7WZ@28221,43CPR@68525,COG1120@1,COG1120@2 NA|NA|NA P ABC transporter PFHLONEA_01583 398767.Glov_3558 4.1e-44 184.5 Desulfuromonadales btuC 3.6.3.34 ko:K02013,ko:K02015 ko02010,map02010 M00240 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 Bacteria 1MV9W@1224,2WN16@28221,42N28@68525,43V85@69541,COG0609@1,COG0609@2 NA|NA|NA P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily PFHLONEA_01587 269799.Gmet_0037 3e-30 138.3 Deltaproteobacteria Bacteria 1N0BX@1224,2WX3U@28221,431VB@68525,COG3794@1,COG3794@2 NA|NA|NA C PFAM blue (type 1) copper domain protein PFHLONEA_01589 305700.B447_16562 9.5e-38 163.7 Rhodocyclales Bacteria 1MWT5@1224,2KV5C@206389,2VH65@28216,COG2928@1,COG2928@2 NA|NA|NA S Protein of unknown function (DUF502) PFHLONEA_01590 330214.NIDE2922 1.1e-126 460.3 Nitrospirae glmU GO:0000270,GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0005975,GO:0005976,GO:0006022,GO:0006023,GO:0006024,GO:0006629,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009252,GO:0009273,GO:0009987,GO:0016051,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0019134,GO:0022610,GO:0030203,GO:0030260,GO:0033692,GO:0034637,GO:0034645,GO:0035635,GO:0040007,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044650,GO:0046872,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0070569,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1903509 2.3.1.157,2.7.7.23 ko:K04042,ko:K11528,ko:K16203 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000,ko01002 3.A.1.5.2 iJN678.glmU,iLJ478.TM1629 Bacteria 3J0CG@40117,COG1207@1,COG1207@2 NA|NA|NA M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain PFHLONEA_01594 316067.Geob_0754 1.5e-83 316.6 Desulfuromonadales boxA 1.14.13.208,1.18.1.2,1.19.1.1 ko:K00528,ko:K15511 ko00362,map00362 R09555,R10159 RC01739 ko00000,ko00001,ko01000 Bacteria 1RABP@1224,2WMRX@28221,42QQA@68525,43U50@69541,COG1145@1,COG1145@2,COG2006@1,COG2006@2 NA|NA|NA C Domain of unknown function (DUF362) PFHLONEA_01595 1379698.RBG1_1C00001G0560 2.9e-73 282.0 unclassified Bacteria suhB GO:0003674,GO:0003824,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0042578,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616 3.1.3.25,3.1.3.7 ko:K01082,ko:K01092 ko00521,ko00562,ko00920,ko01100,ko01120,ko01130,ko04070,map00521,map00562,map00920,map01100,map01120,map01130,map04070 M00131 R00188,R00508,R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000,ko03016 Bacteria 2NP94@2323,COG0483@1,COG0483@2 NA|NA|NA G Inositol monophosphatase PFHLONEA_01597 269799.Gmet_2029 2.3e-66 260.0 Desulfuromonadales ko:K07011 ko00000 Bacteria 1MVBX@1224,2WKRC@28221,42PYQ@68525,43SUS@69541,COG3206@1,COG3206@2 NA|NA|NA M Chain length determinant protein PFHLONEA_01598 316067.Geob_2979 6e-55 221.5 Deltaproteobacteria epsB 2.7.10.1 ko:K08252 ko00000,ko01000 Bacteria 1MVI9@1224,2WMX0@28221,42QS3@68525,COG0489@1,COG0489@2 NA|NA|NA D Capsular exopolysaccharide family PFHLONEA_01599 243231.GSU1981 6.3e-57 228.4 Desulfuromonadales ko:K20920 ko05111,map05111 ko00000,ko00001,ko02000 1.B.66.3.1,1.B.66.3.2 Bacteria 1RI00@1224,2WPSI@28221,42T4A@68525,43UP2@69541,COG5338@1,COG5338@2 NA|NA|NA S Putative beta-barrel porin 2 PFHLONEA_01600 443144.GM21_1599 7.7e-81 307.0 Deltaproteobacteria glmM GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006464,GO:0006468,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008966,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019538,GO:0034641,GO:0034654,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046777,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 R02060 RC00408 ko00000,ko00001,ko01000 iAF987.Gmet_1886,iSBO_1134.SBO_3206 Bacteria 1MU24@1224,2WJTV@28221,42M6I@68525,COG1109@1,COG1109@2 NA|NA|NA G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate PFHLONEA_01601 289376.THEYE_A0680 2.4e-87 328.9 Nitrospirae rbcR Bacteria 3J16P@40117,COG0583@1,COG0583@2,COG1910@1,COG1910@2 NA|NA|NA K Transcriptional regulator PFHLONEA_01602 671143.DAMO_0696 1.6e-61 243.8 unclassified Bacteria cca 2.7.7.19,2.7.7.72 ko:K00970,ko:K00974,ko:K07276,ko:K19545 ko03013,ko03018,map03013,map03018 R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko01504,ko03016,ko03019 Bacteria 2NPB4@2323,COG0617@1,COG0617@2 NA|NA|NA J Poly A polymerase head domain PFHLONEA_01603 491952.Mar181_2286 1.4e-42 179.9 Proteobacteria Bacteria 1MYVB@1224,297A5@1,2ZUHQ@2 NA|NA|NA S Domain of unknown function (DUF4145) PFHLONEA_01604 1123242.JH636437_gene6143 1.3e-13 82.4 Planctomycetes aroB 2.7.1.71,4.2.3.4 ko:K01735,ko:K13829 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412,R03083 RC00002,RC00078,RC00847 ko00000,ko00001,ko00002,ko01000 Bacteria 2IXAM@203682,COG0337@1,COG0337@2 NA|NA|NA E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) PFHLONEA_01605 321332.CYB_0455 2.7e-78 298.5 Synechococcus pdxJ GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 ko:K03474 ko00750,ko01100,map00750,map01100 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000 iAF1260.b2564,iAF987.Gmet_1885,iB21_1397.B21_02422,iBWG_1329.BWG_2328,iEC55989_1330.EC55989_2852,iECBD_1354.ECBD_1117,iECB_1328.ECB_02458,iECDH10B_1368.ECDH10B_2732,iECDH1ME8569_1439.ECDH1ME8569_2491,iECD_1391.ECD_02458,iECH74115_1262.ECH74115_3800,iECIAI1_1343.ECIAI1_2675,iECO103_1326.ECO103_3142,iECO111_1330.ECO111_3290,iECO26_1355.ECO26_3611,iECSE_1348.ECSE_2852,iECSP_1301.ECSP_3509,iECW_1372.ECW_m2792,iECs_1301.ECs3430,iEKO11_1354.EKO11_1169,iEcDH1_1363.EcDH1_1104,iEcE24377_1341.EcE24377A_2850,iEcHS_1320.EcHS_A2719,iEcolC_1368.EcolC_1113,iG2583_1286.G2583_3145,iJO1366.b2564,iJR904.b2564,iWFL_1372.ECW_m2792,iY75_1357.Y75_RS13390 Bacteria 1G0QW@1117,1GZKF@1129,COG0854@1,COG0854@2 NA|NA|NA H Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate PFHLONEA_01606 96561.Dole_1197 3.6e-75 288.9 Desulfobacterales Bacteria 1R83K@1224,28MK7@1,2MISC@213118,2WKYR@28221,2ZAWI@2,42MZ5@68525 NA|NA|NA PFHLONEA_01607 273068.TTE0975 7.1e-52 210.7 Thermoanaerobacterales deoC GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 4.1.2.4,5.4.3.3 ko:K01619,ko:K01844 ko00030,ko00310,map00030,map00310 R01066,R02852,R03275 RC00436,RC00437,RC00719 ko00000,ko00001,ko01000 Bacteria 1TPAJ@1239,249XB@186801,42FFH@68295,COG0274@1,COG0274@2 NA|NA|NA F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate PFHLONEA_01608 644966.Tmar_2150 1.6e-80 306.2 Clostridiales incertae sedis ilvE 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 Bacteria 1TPY2@1239,25CC3@186801,3WDJY@538999,COG0115@1,COG0115@2 NA|NA|NA E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family PFHLONEA_01609 1121481.AUAS01000007_gene1077 8e-219 766.5 Cytophagia prfC GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016150,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02837,ko:K07133 ko00000,ko03012 Bacteria 47JQE@768503,4NFEZ@976,COG4108@1,COG4108@2 NA|NA|NA J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP PFHLONEA_01612 547144.HydHO_0695 8.7e-42 177.6 Bacteria 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria COG0204@1,COG0204@2 NA|NA|NA I Acyl-transferase PFHLONEA_01613 56780.SYN_02018 1.4e-26 125.6 delta/epsilon subdivisions GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 Bacteria 1N0UT@1224,43B8R@68525,COG0011@1,COG0011@2 NA|NA|NA S Thiamine-binding protein PFHLONEA_01615 671143.DAMO_0988 2.1e-35 155.6 unclassified Bacteria Bacteria 2NS26@2323,COG1499@1,COG1499@2 NA|NA|NA J ribosomal large subunit export from nucleus PFHLONEA_01616 269799.Gmet_0936 1.7e-32 145.2 Desulfuromonadales ko:K07451 ko00000,ko01000,ko02048 Bacteria 1MWEQ@1224,2WQ00@28221,42U6P@68525,43V75@69541,COG1403@1,COG1403@2 NA|NA|NA L SMART HNH nuclease PFHLONEA_01617 1121289.JHVL01000030_gene400 2.4e-35 155.2 Clostridiaceae mraZ GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 ko:K03925 ko00000 Bacteria 1V3JD@1239,24HB9@186801,36I1C@31979,COG2001@1,COG2001@2 NA|NA|NA K Belongs to the MraZ family PFHLONEA_01618 386456.JQKN01000007_gene3316 7.6e-09 67.0 Archaea ko:K04749 ko00000,ko03021 Archaea COG1366@1,arCOG06891@2157 NA|NA|NA T PFAM Sulfate transporter antisigma-factor antagonist STAS PFHLONEA_01619 338963.Pcar_2210 5.1e-83 314.7 Desulfuromonadales rsmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 ko:K03438 ko00000,ko01000,ko03009 Bacteria 1MUT4@1224,2WJ8J@28221,42N5Q@68525,43SBK@69541,COG0275@1,COG0275@2 NA|NA|NA J MraW methylase family PFHLONEA_01621 330214.NIDE0755 5e-134 485.0 Nitrospirae ftsI GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.4.16.4 ko:K03587,ko:K08384,ko:K08724,ko:K12552,ko:K12556 ko00550,ko01100,ko01501,map00550,map01100,map01501 ko00000,ko00001,ko01000,ko01011,ko03036 Bacteria 3J0FH@40117,COG0768@1,COG0768@2 NA|NA|NA M Penicillin-binding Protein dimerisation domain PFHLONEA_01622 696281.Desru_3352 4.1e-124 451.8 Peptococcaceae murE GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.10,6.3.2.13,6.3.2.7 ko:K01928,ko:K05362,ko:K15792 ko00300,ko00550,ko01100,map00300,map00550,map01100 R02786,R02788,R04617 RC00064,RC00090,RC00141 ko00000,ko00001,ko01000,ko01011 Bacteria 1TPQE@1239,248Q4@186801,260X6@186807,COG0769@1,COG0769@2 NA|NA|NA M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan PFHLONEA_01624 1095769.CAHF01000005_gene1636 6.8e-08 63.5 Oxalobacteraceae Bacteria 1QZK6@1224,2DKFZ@1,2WHMG@28216,309D6@2,476NY@75682 NA|NA|NA S Domain of unknown function (DUF4382) PFHLONEA_01625 1380346.JNIH01000053_gene6583 9.2e-21 106.7 Bacteria Bacteria COG5485@1,COG5485@2 NA|NA|NA S SnoaL-like polyketide cyclase PFHLONEA_01626 926569.ANT_26630 9.4e-122 443.4 Chloroflexi tas Bacteria 2G5VT@200795,COG0667@1,COG0667@2 NA|NA|NA C Aldo/keto reductase family PFHLONEA_01629 555779.Dthio_PD3478 4e-75 288.5 Desulfovibrionales Bacteria 1NV7D@1224,2M8BU@213115,2WV1N@28221,42ZEV@68525,COG2006@1,COG2006@2 NA|NA|NA S Domain of unknown function (DUF362) PFHLONEA_01630 1047013.AQSP01000092_gene317 2.1e-72 278.9 unclassified Bacteria Bacteria 2NR7M@2323,COG0778@1,COG0778@2 NA|NA|NA C Nitroreductase family PFHLONEA_01635 243231.GSU1458 8.9e-79 301.2 Deltaproteobacteria Bacteria 1NSZ2@1224,2WTRC@28221,42Z7H@68525,COG0457@1,COG0457@2 NA|NA|NA S Tetratricopeptide repeat PFHLONEA_01637 269799.Gmet_2350 1.6e-104 386.3 Desulfuromonadales lpxB GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 GT19 Bacteria 1MVBI@1224,2WJFA@28221,42P35@68525,43SZS@69541,COG0763@1,COG0763@2 NA|NA|NA M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell PFHLONEA_01638 1232410.KI421414_gene2843 3.8e-119 434.9 Desulfuromonadales gnnB iAF987.Gmet_2351 Bacteria 1MUPN@1224,2WJ1Q@28221,42M4C@68525,43T8C@69541,COG0399@1,COG0399@2 NA|NA|NA E Belongs to the DegT DnrJ EryC1 family PFHLONEA_01639 269799.Gmet_2352 7.4e-79 300.8 Desulfuromonadales gnnA ko:K09949 ko00000 iAF987.Gmet_2352 Bacteria 1MV7C@1224,2WK1Y@28221,42NV0@68525,43T3I@69541,COG0673@1,COG0673@2 NA|NA|NA S Oxidoreductase family, NAD-binding Rossmann fold PFHLONEA_01640 880072.Desac_2714 2.3e-81 308.9 Deltaproteobacteria cdsA2 GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008758,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 ko:K00748,ko:K09949 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 GT19 Bacteria 1MWTH@1224,2WK7K@28221,42P40@68525,COG3494@1,COG3494@2 NA|NA|NA S Protein of unknown function (DUF1009) PFHLONEA_01641 96561.Dole_2840 2.5e-30 138.3 Desulfobacterales lpxA GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0008780,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 iIT341.HP1375,iPC815.YPO1056 Bacteria 1MUHQ@1224,2MI18@213118,2WJVP@28221,42NPG@68525,COG1043@1,COG1043@2 NA|NA|NA M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell PFHLONEA_01642 1232410.KI421424_gene1590 3.4e-85 322.0 Desulfuromonadales 2.7.13.3 ko:K10942 ko02020,ko05111,map02020,map05111 M00515 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 1NTTH@1224,2X7F1@28221,43C4K@68525,43TX3@69541,COG3852@1,COG3852@2 NA|NA|NA T Domains HisKA, HATPase_c PFHLONEA_01643 269799.Gmet_2453 6.2e-140 504.2 Desulfuromonadales ko:K02481 ko00000,ko02022 Bacteria 1MU0N@1224,2WIT0@28221,42M03@68525,43TS4@69541,COG2204@1,COG2204@2 NA|NA|NA T response regulator PFHLONEA_01644 580327.Tthe_0716 1.5e-11 75.1 Thermoanaerobacterales copZ ko:K07213 ko04978,map04978 ko00000,ko00001 Bacteria 1VERB@1239,24U5J@186801,42H68@68295,COG2608@1,COG2608@2 NA|NA|NA C PFAM Heavy metal transport detoxification protein PFHLONEA_01645 1379698.RBG1_1C00001G1790 3.4e-104 385.2 unclassified Bacteria 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 Bacteria 2NPSG@2323,COG0191@1,COG0191@2 NA|NA|NA G Fructose-bisphosphate aldolase class-II PFHLONEA_01646 1304888.ATWF01000001_gene623 3.9e-25 122.1 Deferribacteres Bacteria 2DMMW@1,2GFD5@200930,32SIJ@2 NA|NA|NA PFHLONEA_01649 706587.Desti_4753 2.4e-33 147.9 Deltaproteobacteria nuoK GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 ko:K00340 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 iIT341.HP1270 Bacteria 1RH0S@1224,2WRE5@28221,42VAT@68525,COG0713@1,COG0713@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient PFHLONEA_01650 323261.Noc_1119 2e-51 208.8 Gammaproteobacteria nuoJ GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 e_coli_core.b2280,iAF1260.b2280,iAPECO1_1312.APECO1_4285,iB21_1397.B21_02165,iBWG_1329.BWG_2054,iE2348C_1286.E2348C_2420,iEC042_1314.EC042_2521,iEC55989_1330.EC55989_2524,iECABU_c1320.ECABU_c26120,iECBD_1354.ECBD_1381,iECB_1328.ECB_02205,iECDH10B_1368.ECDH10B_2442,iECDH1ME8569_1439.ECDH1ME8569_2217,iECD_1391.ECD_02205,iECED1_1282.ECED1_2744,iECH74115_1262.ECH74115_3419,iECIAI1_1343.ECIAI1_2354,iECIAI39_1322.ECIAI39_2427,iECNA114_1301.ECNA114_2370,iECO103_1326.ECO103_2744,iECO111_1330.ECO111_3028,iECO26_1355.ECO26_3268,iECOK1_1307.ECOK1_2513,iECP_1309.ECP_2319,iECS88_1305.ECS88_2427,iECSE_1348.ECSE_2537,iECSF_1327.ECSF_2157,iECSP_1301.ECSP_3154,iECUMN_1333.ECUMN_2619,iECW_1372.ECW_m2468,iECs_1301.ECs3164,iEKO11_1354.EKO11_1487,iETEC_1333.ETEC_2415,iEcDH1_1363.EcDH1_1377,iEcE24377_1341.EcE24377A_2573,iEcHS_1320.EcHS_A2429,iEcSMS35_1347.EcSMS35_2434,iEcolC_1368.EcolC_1372,iJO1366.b2280,iJR904.b2280,iLF82_1304.LF82_1547,iNRG857_1313.NRG857_11545,iSBO_1134.SBO_2313,iSDY_1059.SDY_2476,iSFV_1184.SFV_2347,iSF_1195.SF2356,iSFxv_1172.SFxv_2600,iSSON_1240.SSON_2337,iS_1188.S2491,iSbBS512_1146.SbBS512_E2656,iUMN146_1321.UM146_05415,iUMNK88_1353.UMNK88_2830,iUTI89_1310.UTI89_C2560,iWFL_1372.ECW_m2468,iY75_1357.Y75_RS11955,iZ_1308.Z3539,ic_1306.c2821 Bacteria 1MWJV@1224,1S65T@1236,COG0839@1,COG0839@2 NA|NA|NA C Belongs to the complex I subunit 6 family PFHLONEA_01651 472759.Nhal_2134 5.6e-65 253.8 Gammaproteobacteria nuoI GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 e_coli_core.b2281,iAF1260.b2281,iAPECO1_1312.APECO1_4284,iB21_1397.B21_02166,iBWG_1329.BWG_2055,iE2348C_1286.E2348C_2421,iEC042_1314.EC042_2522,iEC55989_1330.EC55989_2525,iECABU_c1320.ECABU_c26130,iECBD_1354.ECBD_1380,iECB_1328.ECB_02206,iECDH10B_1368.ECDH10B_2443,iECDH1ME8569_1439.ECDH1ME8569_2218,iECD_1391.ECD_02206,iECED1_1282.ECED1_2745,iECH74115_1262.ECH74115_3420,iECIAI1_1343.ECIAI1_2355,iECIAI39_1322.ECIAI39_2428,iECNA114_1301.ECNA114_2371,iECO103_1326.ECO103_2745,iECO111_1330.ECO111_3029,iECO26_1355.ECO26_3269,iECOK1_1307.ECOK1_2514,iECP_1309.ECP_2320,iECS88_1305.ECS88_2428,iECSE_1348.ECSE_2538,iECSF_1327.ECSF_2158,iECSP_1301.ECSP_3155,iECUMN_1333.ECUMN_2620,iECW_1372.ECW_m2469,iECs_1301.ECs3165,iEKO11_1354.EKO11_1486,iETEC_1333.ETEC_2416,iEcDH1_1363.EcDH1_1376,iEcE24377_1341.EcE24377A_2574,iEcHS_1320.EcHS_A2430,iEcSMS35_1347.EcSMS35_2435,iEcolC_1368.EcolC_1371,iG2583_1286.G2583_2818,iJO1366.b2281,iJR904.b2281,iLF82_1304.LF82_1546,iNRG857_1313.NRG857_11550,iPC815.YPO2548,iSBO_1134.SBO_2314,iSFV_1184.SFV_2348,iSF_1195.SF2357,iSFxv_1172.SFxv_2601,iS_1188.S2492,iSbBS512_1146.SbBS512_E2657,iUMN146_1321.UM146_05410,iUMNK88_1353.UMNK88_2831,iUTI89_1310.UTI89_C2561,iWFL_1372.ECW_m2469,iY75_1357.Y75_RS11960,iZ_1308.Z3540,ic_1306.c2822 Bacteria 1MV90@1224,1RN32@1236,COG1143@1,COG1143@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient PFHLONEA_01652 929556.Solca_3106 1.6e-65 255.8 Sphingobacteriia nuoH 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 1IVA3@117747,4NGK7@976,COG1005@1,COG1005@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone PFHLONEA_01653 1121439.dsat_1278 6e-85 320.9 Desulfovibrionales Bacteria 1MWMZ@1224,2M9ER@213115,2WMHU@28221,42P7W@68525,COG0726@1,COG0726@2 NA|NA|NA G TIGRFAM polysaccharide deactylase family protein, PEP-CTERM locus subfamily PFHLONEA_01654 215803.DB30_8808 1.1e-81 310.5 Bacteria Bacteria COG5653@1,COG5653@2 NA|NA|NA M Protein involved in cellulose biosynthesis PFHLONEA_01655 1538295.JY96_10875 1.4e-63 250.0 unclassified Burkholderiales ko:K00318 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 R10507 RC00083 ko00000,ko00001,ko01000 Bacteria 1KMRX@119065,1PFQW@1224,2VZ1T@28216,COG0506@1,COG0506@2 NA|NA|NA E proline dehydrogenase activity PFHLONEA_01656 1089544.KB912942_gene1735 6.1e-52 213.0 Actinobacteria Bacteria 2GYU3@201174,COG0561@1,COG0561@2 NA|NA|NA S phosphatase activity PFHLONEA_01657 1499967.BAYZ01000167_gene6755 2.6e-106 392.1 Bacteria Bacteria COG5653@1,COG5653@2 NA|NA|NA M Protein involved in cellulose biosynthesis PFHLONEA_01658 330214.NIDE2865 7e-98 364.4 Bacteria Bacteria COG0399@1,COG0399@2 NA|NA|NA E UDP-4-amino-4-deoxy-L-arabinose aminotransferase PFHLONEA_01659 330214.NIDE2864 4.2e-129 468.0 Nitrospirae gt2M Bacteria 3J15U@40117,COG1215@1,COG1215@2 NA|NA|NA M Glycosyltransferase like family 2 PFHLONEA_01660 330214.NIDE2861 5e-70 271.6 Nitrospirae Bacteria 3J1D4@40117,COG0726@1,COG0726@2 NA|NA|NA G Polysaccharide deacetylase PFHLONEA_01661 443143.GM18_1652 7.2e-57 228.0 Desulfuromonadales Bacteria 1MU9C@1224,2WPW2@28221,42T55@68525,43UYN@69541,COG0438@1,COG0438@2 NA|NA|NA H Glycosyltransferase Family 4 PFHLONEA_01662 443143.GM18_1634 1.5e-84 319.7 Deltaproteobacteria walW Bacteria 1MX6K@1224,2WUQF@28221,42Z2Y@68525,COG0726@1,COG0726@2 NA|NA|NA G lipopolysaccharide biosynthesis protein PFHLONEA_01663 502025.Hoch_5827 2.1e-46 193.4 Myxococcales celD Bacteria 1N7WR@1224,2WSGU@28221,2YX5B@29,42VU5@68525,COG5653@1,COG5653@2 NA|NA|NA M Acetyltransferase (GNAT) domain PFHLONEA_01664 768671.ThimaDRAFT_1955 2.3e-28 133.3 Bacteria ko:K20444 ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 Bacteria COG1216@1,COG1216@2 NA|NA|NA V Glycosyl transferase, family 2 PFHLONEA_01666 56780.SYN_02462 4.6e-93 348.6 Syntrophobacterales ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 Bacteria 1MWX5@1224,2MRDS@213462,2X5KP@28221,42S0Z@68525,COG1538@1,COG1538@2 NA|NA|NA MU Outer membrane efflux protein PFHLONEA_01667 247490.KSU1_C1013 1.8e-33 149.1 Bacteria yvkB GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141 Bacteria COG1309@1,COG1309@2 NA|NA|NA K transcriptional regulator PFHLONEA_01668 515635.Dtur_0011 3.9e-40 171.0 Bacteria bfr GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008150,GO:0009987,GO:0019725,GO:0030003,GO:0042592,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0097577,GO:0098771 1.16.3.1 ko:K03594 ko00860,map00860 R00078 RC02758 ko00000,ko00001,ko01000 Bacteria COG2193@1,COG2193@2 NA|NA|NA P ferroxidase activity PFHLONEA_01669 1232437.KL662047_gene5175 6.8e-45 186.8 Desulfobacterales bacB GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016853,GO:0016860,GO:0016863,GO:0016999,GO:0017000,GO:0017144,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0046872,GO:0046914,GO:0050897 5.3.3.19,5.4.99.5 ko:K04093,ko:K19547 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025,M00787 R01715 RC03116 ko00000,ko00001,ko00002,ko01000 Bacteria 1N0G1@1224,2MNEN@213118,2WPN5@28221,42U3P@68525,COG1917@1,COG1917@2 NA|NA|NA S Cupin domain PFHLONEA_01670 344747.PM8797T_14716 9.3e-13 80.1 Bacteria Bacteria 2DX6Z@1,343NZ@2 NA|NA|NA S SnoaL-like domain PFHLONEA_01671 1268237.G114_10895 9.5e-36 156.0 Proteobacteria Bacteria 1N2NN@1224,2DWY1@1,342G1@2 NA|NA|NA PFHLONEA_01674 269799.Gmet_0715 1.2e-21 109.8 Desulfuromonadales Bacteria 1PXCU@1224,2CHSG@1,2WVAX@28221,316CZ@2,4308W@68525,43V1W@69541 NA|NA|NA S Domain of unknown function (DUF4149) PFHLONEA_01675 586416.GZ22_03485 6.6e-17 93.2 Bacilli rluD 5.4.99.23,5.4.99.28,5.4.99.29 ko:K06177,ko:K06180 ko00000,ko01000,ko03009,ko03016 Bacteria 1TSPG@1239,4HBGS@91061,COG0564@1,COG0564@2 NA|NA|NA J Responsible for synthesis of pseudouridine from uracil PFHLONEA_01676 338963.Pcar_0283 1.2e-21 109.4 delta/epsilon subdivisions Bacteria 1RBWN@1224,43BBQ@68525,COG3439@1,COG3439@2 NA|NA|NA S Domain of unknown function DUF302 PFHLONEA_01677 111781.Lepto7376_2023 8.7e-09 67.4 Oscillatoriales Z012_00420 Bacteria 1G3RC@1117,1H7H9@1150,COG5413@1,COG5413@2 NA|NA|NA S integral membrane protein PFHLONEA_01678 349163.Acry_0348 1.3e-19 102.8 Alphaproteobacteria ko:K07112 ko00000 Bacteria 1RIWE@1224,2U4F1@28211,COG2391@1,COG2391@2 NA|NA|NA S Sulphur transport PFHLONEA_01679 443144.GM21_2333 1.7e-90 340.1 Desulfuromonadales glnD 2.7.7.59 ko:K00990 ko02020,map02020 ko00000,ko00001,ko01000 Bacteria 1MV54@1224,2WINN@28221,42MN5@68525,43SYQ@69541,COG2844@1,COG2844@2 NA|NA|NA H Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism PFHLONEA_01680 1123376.AUIU01000014_gene576 3.2e-66 260.8 Bacteria ko:K09800 ko00000,ko02000 Bacteria COG2911@1,COG2911@2 NA|NA|NA S protein secretion PFHLONEA_01681 1232410.KI421418_gene2160 1.6e-272 945.7 Desulfuromonadales polA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 Bacteria 1MU31@1224,2WJ3W@28221,42NAV@68525,43RY4@69541,COG0258@1,COG0258@2,COG0749@1,COG0749@2 NA|NA|NA L DNA polymerase A domain PFHLONEA_01683 449447.MAE_03350 1.3e-22 113.2 Cyanobacteria ko:K07494 ko00000 Bacteria 1G0GB@1117,COG3335@1,COG3335@2,COG3415@1,COG3415@2 NA|NA|NA L Winged helix-turn helix PFHLONEA_01684 78245.Xaut_3589 1.3e-18 99.8 Alphaproteobacteria ko:K07494 ko00000 Bacteria 1Q66S@1224,2UR2V@28211,COG3335@1,COG3335@2 NA|NA|NA L DDE superfamily endonuclease PFHLONEA_01686 1499967.BAYZ01000038_gene2261 2.2e-90 338.6 unclassified Bacteria Bacteria 2NPGI@2323,COG0705@1,COG0705@2 NA|NA|NA S (Rhomboid) family PFHLONEA_01687 316067.Geob_1341 3.1e-27 127.9 Bacteria Bacteria 2C5I4@1,33FNH@2 NA|NA|NA PFHLONEA_01688 269799.Gmet_0534 1.4e-109 402.9 Deltaproteobacteria Bacteria 1RGTJ@1224,293RH@1,2WNTI@28221,2ZR74@2,42RWW@68525 NA|NA|NA C Cytochrome c554 and c-prime PFHLONEA_01689 358681.BBR47_36230 2.4e-138 498.8 Paenibacillaceae fabF 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 1TPA7@1239,26QJA@186822,4H9SD@91061,COG0304@1,COG0304@2 NA|NA|NA I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP PFHLONEA_01690 1121468.AUBR01000017_gene2382 1.3e-32 147.1 Thermoanaerobacterales ko:K09942 ko00000 Bacteria 1V2ZT@1239,24H5R@186801,42GZA@68295,COG3330@1,COG3330@2 NA|NA|NA S Domain of unknown function (DUF4912) PFHLONEA_01691 247490.KSU1_D0142 1.3e-226 792.3 Planctomycetes 2.4.1.18 ko:K03406,ko:K16149 ko00500,ko01100,ko01110,ko02020,ko02030,map00500,map01100,map01110,map02020,map02030 M00565 R02110 ko00000,ko00001,ko00002,ko01000,ko02035 GH57 Bacteria 2J2W9@203682,COG1543@1,COG1543@2 NA|NA|NA G Domain of unknown function (DUF1957) PFHLONEA_01692 338963.Pcar_2765 4.3e-144 518.1 Desulfuromonadales larD 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 R00475 RC00042 ko00000,ko00001,ko01000 iAF987.Gmet_3245 Bacteria 1MU6Y@1224,2WIQ1@28221,42M0V@68525,43SAR@69541,COG0277@1,COG0277@2 NA|NA|NA C FAD linked oxidases, C-terminal domain PFHLONEA_01693 316067.Geob_3043 1.1e-82 313.9 Desulfuromonadales Bacteria 1RFCV@1224,2WP0D@28221,42S1B@68525,43VZG@69541,COG2239@1,COG2239@2 NA|NA|NA P MgtE intracellular N domain PFHLONEA_01694 635013.TherJR_2354 2.8e-15 89.0 Peptococcaceae nptA ko:K14683 ko00000,ko02000,ko04147 2.A.58.1 Bacteria 1UDIA@1239,25I9C@186801,266EZ@186807,COG1283@1,COG1283@2 NA|NA|NA P sodium-dependent phosphate transmembrane transporter activity PFHLONEA_01695 748449.Halha_1430 2.7e-42 179.1 Halanaerobiales ylbK GO:0003674,GO:0003824,GO:0016787 ko:K07001 ko00000 Bacteria 1UUVB@1239,24HQS@186801,3WAJH@53433,COG1752@1,COG1752@2 NA|NA|NA S PFAM Patatin-like phospholipase PFHLONEA_01696 671143.DAMO_1397 4.4e-81 308.1 unclassified Bacteria livH GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015190,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015820,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0043090,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098713,GO:0098739,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039 ko:K01997 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 iJN746.PP_4866,iSFV_1184.SFV_3460,iSF_1195.SF3475,iSFxv_1172.SFxv_3791,iS_1188.S4288 Bacteria 2NP7Z@2323,COG0559@1,COG0559@2 NA|NA|NA E Branched-chain amino acid transport system / permease component PFHLONEA_01697 671143.DAMO_1398 1e-23 116.3 unclassified Bacteria livK GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0008150,GO:0015711,GO:0015803,GO:0015804,GO:0015818,GO:0015820,GO:0015829,GO:0015849,GO:0016597,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0070728,GO:0071702,GO:0071705 ko:K01999 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 iECNA114_1301.ECNA114_3569,iECSF_1327.ECSF_3279,iECs_1301.ECs4309,iEcSMS35_1347.EcSMS35_3743,iG2583_1286.G2583_4163,iSFxv_1172.SFxv_3794,iSSON_1240.SSON_3698,iS_1188.S4285,iUTI89_1310.UTI89_C3965,iYL1228.KPN_03820,iZ_1308.Z4834 Bacteria 2NPSN@2323,COG0683@1,COG0683@2 NA|NA|NA E Receptor family ligand binding region PFHLONEA_01700 1158338.JNLJ01000001_gene338 4e-78 298.9 Aquificae pilR ko:K02667 ko02020,map02020 M00501 ko00000,ko00001,ko00002,ko02022,ko02035 Bacteria 2G3R2@200783,COG2204@1,COG2204@2 NA|NA|NA T Bacterial regulatory protein, Fis family PFHLONEA_01701 1460640.JCM19046_1537 1.1e-18 101.3 Bacillus pilS GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0009653,GO:0009987,GO:0030154,GO:0030435,GO:0032502,GO:0042802,GO:0043934,GO:0043937,GO:0043938,GO:0048518,GO:0048646,GO:0048856,GO:0048869,GO:0050789,GO:0050793,GO:0051094,GO:0065007 2.7.13.3 ko:K02491,ko:K02668,ko:K07698,ko:K17763 ko02020,map02020 M00485,M00501 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035,ko03021 Bacteria 1TRH0@1239,1ZARI@1386,4HD4A@91061,COG3852@1,COG3852@2,COG4191@1,COG4191@2 NA|NA|NA T COG0642 Signal transduction histidine kinase PFHLONEA_01702 404380.Gbem_3239 1.5e-12 78.2 Deltaproteobacteria iHN637.CLJU_RS07840 Bacteria 1N0XH@1224,2X6IC@28221,43B4Q@68525,COG1914@1,COG1914@2 NA|NA|NA P PFAM natural resistance-associated macrophage protein PFHLONEA_01703 316067.Geob_2394 4.3e-62 244.6 Desulfuromonadales nth GO:0000702,GO:0000703,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006289,GO:0006296,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033683,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.11.2,4.2.99.18 ko:K01142,ko:K10773 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 1MUYQ@1224,2WN0H@28221,42R18@68525,43UH3@69541,COG0177@1,COG0177@2 NA|NA|NA L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate PFHLONEA_01704 880073.Calab_2509 3.4e-81 308.1 unclassified Bacteria queC 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 R09978 RC00959 ko00000,ko00001,ko01000,ko03016 iAF987.Gmet_3075 Bacteria 2NPD6@2323,COG0603@1,COG0603@2 NA|NA|NA F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) PFHLONEA_01705 247490.KSU1_C1594 6.3e-15 86.3 Planctomycetes Bacteria 2A5W3@1,2J4MS@203682,30UMY@2 NA|NA|NA S Domain of unknown function (DUF1858) PFHLONEA_01706 123214.PERMA_1556 5e-88 330.9 Bacteria 3.2.1.52 ko:K12373 ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142 M00079 R00022,R06004,R11316 RC00049 ko00000,ko00001,ko00002,ko01000,ko03110 GH20 Bacteria COG5492@1,COG5492@2 NA|NA|NA N domain, Protein PFHLONEA_01707 404589.Anae109_2759 9e-39 167.2 delta/epsilon subdivisions ko:K02305 ko00910,ko01120,map00910,map01120 M00529 R00294 RC02794 ko00000,ko00001,ko00002 3.D.4.10 Bacteria 1RDSI@1224,42WEW@68525,COG2010@1,COG2010@2 NA|NA|NA C cytochrome c PFHLONEA_01708 404380.Gbem_1248 1.4e-123 449.9 Deltaproteobacteria norB GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016661,GO:0016662,GO:0016966,GO:0055114 1.7.2.5 ko:K04561 ko00910,ko01120,map00910,map01120 M00529 R00294 RC02794 ko00000,ko00001,ko00002,ko01000 3.D.4.10 Bacteria 1MVT1@1224,2WKTG@28221,42NBM@68525,COG3256@1,COG3256@2 NA|NA|NA P PFAM Cytochrome c oxidase, subunit I PFHLONEA_01710 269799.Gmet_0261 2.5e-92 346.3 Desulfuromonadales 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 Bacteria 1NRG9@1224,2WTKJ@28221,42YC6@68525,43TP5@69541,COG1846@1,COG1846@2 NA|NA|NA K Domain of unknown function (DUF4388) PFHLONEA_01711 1121918.ARWE01000001_gene1396 9.9e-141 506.5 Desulfuromonadales pilT-2 ko:K02669 ko00000,ko02035,ko02044 3.A.15.2 Bacteria 1R6FY@1224,2WK57@28221,42MPJ@68525,43SCV@69541,COG2805@1,COG2805@2 NA|NA|NA NU Type II/IV secretion system protein PFHLONEA_01712 1123376.AUIU01000011_gene1021 3.5e-28 131.7 Nitrospirae nudF 3.6.1.13 ko:K01515 ko00230,map00230 R01054 RC00002 ko00000,ko00001,ko01000 Bacteria 3J0TN@40117,COG0494@1,COG0494@2 NA|NA|NA L NUDIX domain PFHLONEA_01713 909663.KI867150_gene1861 5.1e-62 244.2 Syntrophobacterales Bacteria 1NANP@1224,2MQJ5@213462,2WIJ7@28221,42Q16@68525,COG0655@1,COG0655@2 NA|NA|NA S PFAM NADPH-dependent FMN reductase PFHLONEA_01714 247490.KSU1_C1682 5.7e-223 780.4 Planctomycetes 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 R02111 ko00000,ko00001,ko01000 GT35 Bacteria 2IY0J@203682,COG0058@1,COG0058@2 NA|NA|NA G COG0058 Glucan phosphorylase PFHLONEA_01717 272134.KB731324_gene4275 7.9e-62 243.8 Oscillatoriales hesA Bacteria 1G0HR@1117,1H7HY@1150,COG0476@1,COG0476@2 NA|NA|NA H Dinucleotide-utilizing enzyme possibly involved in molybdopterin or thiamin biosynthesis PFHLONEA_01718 410358.Mlab_0679 5.6e-81 307.8 Methanomicrobia nifB ko:K02585 ko00000 Archaea 2N96X@224756,2XU9R@28890,COG0535@1,arCOG00956@2157 NA|NA|NA S PFAM Radical SAM domain protein PFHLONEA_01719 1121456.ATVA01000014_gene561 7e-87 327.4 Desulfovibrionales ko:K07098 ko00000 Bacteria 1MUH5@1224,2MAUU@213115,2WPMH@28221,42SS8@68525,COG1408@1,COG1408@2 NA|NA|NA S PFAM Metallophosphoesterase PFHLONEA_01720 1173027.Mic7113_4358 1.4e-68 266.5 Oscillatoriales 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 Bacteria 1FZX6@1117,1H94D@1150,COG0412@1,COG0412@2 NA|NA|NA Q PFAM Dienelactone hydrolase family PFHLONEA_01721 335543.Sfum_3774 7.3e-80 305.8 Syntrophobacterales Bacteria 1NSC1@1224,2MQQM@213462,2X7QS@28221,43CFQ@68525,COG3164@1,COG3164@2 NA|NA|NA S AsmA-like C-terminal region PFHLONEA_01723 289376.THEYE_A0084 2e-88 332.0 Nitrospirae trpB 4.2.1.20 ko:K01696,ko:K06001 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 Bacteria 3J1FC@40117,COG1350@1,COG1350@2 NA|NA|NA E Pyridoxal-phosphate dependent enzyme PFHLONEA_01724 880072.Desac_1567 1.4e-09 69.7 Syntrophobacterales Bacteria 1P7TZ@1224,290YH@1,2MSEA@213462,2WXS0@28221,2ZNK8@2,433I3@68525 NA|NA|NA PFHLONEA_01725 289376.THEYE_A1917 1.4e-45 189.9 Nitrospirae crp ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 ko00000,ko00001,ko03000 Bacteria 3J182@40117,COG0664@1,COG0664@2 NA|NA|NA K Cyclic nucleotide-monophosphate binding domain PFHLONEA_01726 1123376.AUIU01000019_gene1244 2.1e-103 382.5 Bacteria pta ko:K06873 ko00000 Bacteria COG0857@1,COG0857@2 NA|NA|NA C belongs to the CobB CobQ family PFHLONEA_01727 289376.THEYE_A1602 1.5e-225 789.3 Nitrospirae 6.2.1.13 ko:K01905,ko:K09181,ko:K22224 ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120 R00229,R00920 RC00004,RC00012,RC00014 ko00000,ko00001,ko01000,ko01004 Bacteria 3J0ZI@40117,COG0045@1,COG0045@2,COG1042@1,COG1042@2 NA|NA|NA C ATP-grasp domain PFHLONEA_01728 635013.TherJR_0525 2.6e-261 907.9 Peptococcaceae ko:K18122 ko00650,ko01100,ko01200,map00650,map01100,map01200 R05336 RC00012,RC00014 ko00000,ko00001,ko01000 iAF987.Gmet_2142 Bacteria 1TPHC@1239,247V0@186801,260IW@186807,COG0427@1,COG0427@2,COG1670@1,COG1670@2 NA|NA|NA C PFAM Acetyl-CoA hydrolase transferase PFHLONEA_01729 290397.Adeh_1209 5.6e-128 465.7 Deltaproteobacteria 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 Bacteria 1QTYC@1224,2WKQF@28221,42Q43@68525,COG0457@1,COG0457@2,COG4262@1,COG4262@2 NA|NA|NA S Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine PFHLONEA_01732 545276.KB898724_gene1998 2.9e-73 283.1 Chromatiales cbrA Bacteria 1RCM9@1224,1T44V@1236,1WWXN@135613,COG0591@1,COG0591@2,COG4191@1,COG4191@2 NA|NA|NA T His Kinase A (phosphoacceptor) domain PFHLONEA_01733 1123376.AUIU01000018_gene44 2.6e-122 445.7 Nitrospirae cbrB Bacteria 3J10B@40117,COG2204@1,COG2204@2 NA|NA|NA T Sigma-54 interaction domain PFHLONEA_01734 667014.Thein_2063 7.7e-57 228.4 Thermodesulfobacteria 2.7.13.3 ko:K07709 ko02020,map02020 M00499 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 2GIGP@200940,COG4191@1,COG4191@2 NA|NA|NA T His Kinase A (phosphoacceptor) domain PFHLONEA_01741 56780.SYN_02346 1.2e-92 346.3 Deltaproteobacteria 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 Bacteria 1MW7S@1224,2X5CC@28221,42Q9U@68525,COG0412@1,COG0412@2 NA|NA|NA Q BAAT / Acyl-CoA thioester hydrolase C terminal PFHLONEA_01744 935863.AWZR01000003_gene2752 1.8e-13 82.0 Xanthomonadales Bacteria 1Q7T4@1224,1TH5X@1236,1XA4T@135614,2DZI5@1,32VBA@2 NA|NA|NA S ABC-2 family transporter protein PFHLONEA_01745 1131269.AQVV01000011_gene2517 1e-204 719.9 Bacteria parE GO:0000819,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0022402,GO:0030541,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0098813,GO:0140097,GO:1901360 5.99.1.3 ko:K02470,ko:K02622 ko00000,ko01000,ko02048,ko03032,ko03036,ko03400 Bacteria COG0187@1,COG0187@2 NA|NA|NA L DNA topoisomerase II activity PFHLONEA_01746 690850.Desaf_3380 5.1e-51 208.4 Desulfovibrionales 2.1.1.302 ko:K21377 ko00000,ko01000 Bacteria 1QW86@1224,2MA1B@213115,2WJJS@28221,42N1Q@68525,COG0500@1,COG0500@2 NA|NA|NA Q O-methyltransferase, family 2 PFHLONEA_01747 1499967.BAYZ01000100_gene3449 5.8e-31 140.6 Bacteria msrA 1.8.4.11,1.8.4.12 ko:K07304,ko:K12267 ko00000,ko01000 Bacteria COG0225@1,COG0225@2 NA|NA|NA O peptide-methionine (S)-S-oxide reductase activity PFHLONEA_01749 386456.JQKN01000004_gene198 3.1e-54 218.0 Euryarchaeota msrB 1.8.4.11,1.8.4.12 ko:K07305,ko:K12267 ko00000,ko01000 Archaea 2XXVK@28890,COG0229@1,arCOG02815@2157 NA|NA|NA O COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase PFHLONEA_01750 338969.Rfer_0358 1.2e-134 486.5 Comamonadaceae Bacteria 1NE49@1224,2VNGV@28216,4ADNV@80864,COG0477@1,COG2814@2 NA|NA|NA EGP Major Facilitator Superfamily PFHLONEA_01751 443598.AUFA01000028_gene7138 3.6e-63 247.7 Alphaproteobacteria Bacteria 1MYDE@1224,2TV61@28211,COG4275@1,COG4275@2 NA|NA|NA S Chromate resistance exported protein PFHLONEA_01753 1038859.AXAU01000001_gene3619 1.6e-47 195.7 Bradyrhizobiaceae Bacteria 1RDM5@1224,2UG54@28211,3JY4A@41294,COG4922@1,COG4922@2 NA|NA|NA S SnoaL-like polyketide cyclase PFHLONEA_01754 237368.SCABRO_00634 3.2e-60 238.0 Planctomycetes hycG Bacteria 2J033@203682,COG3260@1,COG3260@2 NA|NA|NA C NADH ubiquinone oxidoreductase, 20 Kd subunit PFHLONEA_01755 765913.ThidrDRAFT_4195 1.3e-178 633.3 Chromatiales hyfB Bacteria 1MXRW@1224,1RM9Q@1236,1WW1W@135613,COG0651@1,COG0651@2 NA|NA|NA CP Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit PFHLONEA_01756 1116472.MGMO_167c00190 6.6e-88 330.9 Methylococcales hycD Bacteria 1MXV5@1224,1RPCY@1236,1XE7T@135618,COG0650@1,COG0650@2 NA|NA|NA C NADH dehydrogenase PFHLONEA_01757 909663.KI867150_gene273 2e-44 185.3 Syntrophobacterales isplu5A ko:K07491 ko00000 Bacteria 1N7RA@1224,2MSB6@213462,2X6VU@28221,43BHH@68525,COG1943@1,COG1943@2 NA|NA|NA L Transposase IS200 like PFHLONEA_01758 311424.DhcVS_1309 1.8e-25 121.7 Dehalococcoidia ko:K07483,ko:K07497 ko00000 Bacteria 2GAW0@200795,34DGC@301297,COG2963@1,COG2963@2 NA|NA|NA L Transposase PFHLONEA_01759 255470.cbdbA1487 9.6e-107 393.3 Dehalococcoidia Bacteria 2G8GQ@200795,34DDP@301297,COG2801@1,COG2801@2 NA|NA|NA L PFAM Integrase catalytic region PFHLONEA_01760 316067.Geob_3374 8.6e-117 426.8 Desulfuromonadales pilB ko:K02454,ko:K02504,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 Bacteria 1MU7V@1224,2WIPP@28221,42M51@68525,43TCZ@69541,COG2804@1,COG2804@2 NA|NA|NA NU General secretory system II, protein E domain protein PFHLONEA_01761 316067.Geob_3373 2.2e-151 542.0 Deltaproteobacteria pilT ko:K02669 ko00000,ko02035,ko02044 3.A.15.2 Bacteria 1MU3J@1224,2WIMF@28221,42M7F@68525,COG2805@1,COG2805@2 NA|NA|NA NU twitching motility protein PFHLONEA_01762 1232410.KI421416_gene2594 6.6e-125 454.1 Desulfuromonadales pilC ko:K02653 ko00000,ko02035,ko02044 3.A.15.2 Bacteria 1MV4U@1224,2WJ0V@28221,42NES@68525,43RZ2@69541,COG1459@1,COG1459@2 NA|NA|NA NU Type II secretion system (T2SS), protein F PFHLONEA_01763 1499967.BAYZ01000027_gene1787 6.5e-99 368.2 unclassified Bacteria pilS 2.7.13.3 ko:K02668 ko02020,map02020 M00501 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 Bacteria 2NP6K@2323,COG5000@1,COG5000@2 NA|NA|NA T His Kinase A (phosphoacceptor) domain PFHLONEA_01765 1254432.SCE1572_15570 1.2e-49 204.5 Myxococcales ko:K05802 ko00000,ko02000 1.A.23.1.1 Bacteria 1QX62@1224,2WNY0@28221,2YVPP@29,42S57@68525,COG0664@1,COG0664@2,COG3264@1,COG3264@2 NA|NA|NA MT Mechanosensitive ion channel PFHLONEA_01766 997346.HMPREF9374_0087 1.2e-50 206.5 Thermoactinomycetaceae engB GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:0097367,GO:1901265,GO:1901363 ko:K03978 ko00000,ko03036 Bacteria 1TSPW@1239,27BMU@186824,4HBXZ@91061,COG0218@1,COG0218@2 NA|NA|NA D Ferrous iron transport protein B PFHLONEA_01767 330214.NIDE0260 3.8e-168 597.8 Nitrospirae clpX GO:0000166,GO:0000502,GO:0002020,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009376,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019899,GO:0019904,GO:0030163,GO:0030164,GO:0030312,GO:0030554,GO:0031333,GO:0031597,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0043335,GO:0044087,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0051704,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0097718,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 ko:K03544 ko04112,map04112 ko00000,ko00001,ko03110 Bacteria 3J0AM@40117,COG1219@1,COG1219@2 NA|NA|NA O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP PFHLONEA_01768 436114.SYO3AOP1_0322 8.3e-81 306.6 Aquificae clpP 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 ko00000,ko00001,ko01000,ko01002 Bacteria 2G3IM@200783,COG0740@1,COG0740@2 NA|NA|NA O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins PFHLONEA_01769 471223.GWCH70_2588 1.1e-80 307.4 Geobacillus tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 ko:K03545 ko00000 Bacteria 1TQQ8@1239,1WEKT@129337,4H9Q8@91061,COG0544@1,COG0544@2 NA|NA|NA D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase PFHLONEA_01774 1121440.AUMA01000009_gene681 3.6e-91 341.3 Desulfovibrionales livF ko:K01996 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 1MVVC@1224,2MGE1@213115,2WJAH@28221,42MSC@68525,COG0410@1,COG0410@2 NA|NA|NA E ATPases associated with a variety of cellular activities PFHLONEA_01775 1121440.AUMA01000009_gene682 2.1e-94 352.1 Desulfovibrionales ko:K01995 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 1MUFT@1224,2M9HK@213115,2WMN1@28221,42QV6@68525,COG0411@1,COG0411@2 NA|NA|NA E pfam abc PFHLONEA_01776 1121440.AUMA01000009_gene683 4.2e-111 407.9 Desulfovibrionales ko:K01998 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 1MU52@1224,2MA30@213115,2WNVC@28221,42RI3@68525,COG4177@1,COG4177@2 NA|NA|NA E Belongs to the binding-protein-dependent transport system permease family PFHLONEA_01777 1121440.AUMA01000009_gene684 9e-130 469.9 Desulfovibrionales ko:K01997 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 1N5XH@1224,2M8YK@213115,2WIRP@28221,42PN7@68525,COG0559@1,COG0559@2 NA|NA|NA E Belongs to the binding-protein-dependent transport system permease family PFHLONEA_01778 1121440.AUMA01000009_gene685 3.9e-146 524.6 Desulfovibrionales ko:K01999 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 1MWQB@1224,2M994@213115,2WM53@28221,42PN2@68525,COG0683@1,COG0683@2 NA|NA|NA E PFAM Extracellular ligand-binding receptor PFHLONEA_01779 338963.Pcar_0444 1e-90 339.7 Desulfuromonadales frdB 1.3.5.1,1.3.5.4 ko:K00240,ko:K00245 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00149,M00150,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2395 Bacteria 1MVHS@1224,2WK9D@28221,42M2J@68525,43S0Z@69541,COG0479@1,COG0479@2 NA|NA|NA C 2Fe-2S iron-sulfur cluster binding domain PFHLONEA_01780 1123376.AUIU01000016_gene333 6.4e-30 136.7 Nitrospirae prs GO:0003674,GO:0003824,GO:0004749,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016772,GO:0016778,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2848 Bacteria 3J0D0@40117,COG0462@1,COG0462@2 NA|NA|NA F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) PFHLONEA_01781 330214.NIDE0782 1e-43 183.7 Nitrospirae ctc GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02897 ko03010,map03010 M00178 ko00000,ko00001,ko00002,ko03011 Bacteria 3J0NK@40117,COG1825@1,COG1825@2 NA|NA|NA J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance PFHLONEA_01782 1408254.T458_25610 2.5e-42 178.7 Paenibacillaceae pth GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016787,GO:0016788,GO:0040007,GO:0044464,GO:0052689,GO:0071944,GO:0140098,GO:0140101 3.1.1.29 ko:K01056 ko00000,ko01000,ko03012 Bacteria 1V3NB@1239,26QYM@186822,4HH2Z@91061,COG0193@1,COG0193@2 NA|NA|NA J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis PFHLONEA_01783 243231.GSU0664 4.6e-133 481.1 Desulfuromonadales ychF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 ko:K06942 ko00000,ko03009 Bacteria 1MVM4@1224,2WIZZ@28221,42MNJ@68525,43T1T@69541,COG0012@1,COG0012@2 NA|NA|NA J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner PFHLONEA_01784 1242864.D187_005224 8.1e-73 281.2 Deltaproteobacteria capA ko:K07282 ko00000 Bacteria 1Q4SV@1224,2WV46@28221,42ZT3@68525,COG2843@1,COG2843@2 NA|NA|NA M Bacterial capsule synthesis protein PGA_cap PFHLONEA_01785 1123371.ATXH01000019_gene589 4.2e-57 227.6 Thermodesulfobacteria Bacteria 2GHTQ@200940,COG0778@1,COG0778@2 NA|NA|NA C Putative TM nitroreductase PFHLONEA_01787 909663.KI867150_gene1244 8.4e-54 216.5 Syntrophobacterales npd 1.13.12.16 ko:K00459 ko00910,map00910 R00025 RC02541,RC02759 ko00000,ko00001,ko01000 Bacteria 1N52W@1224,2MQUQ@213462,2WKX7@28221,42N6F@68525,COG2070@1,COG2070@2 NA|NA|NA S Nitronate monooxygenase PFHLONEA_01788 243231.GSU2501 2e-127 462.6 Desulfuromonadales Bacteria 1NPVB@1224,28WYN@1,2WTBQ@28221,30ZZ9@2,42XW6@68525,43VPR@69541 NA|NA|NA PFHLONEA_01796 269799.Gmet_2583 5.2e-144 518.5 Deltaproteobacteria Bacteria 1R9AF@1224,2WTP2@28221,42YQG@68525,COG2132@1,COG2132@2 NA|NA|NA Q Multicopper oxidase PFHLONEA_01798 335543.Sfum_2247 1.8e-112 413.3 Syntrophobacterales cusB ko:K07798,ko:K15727 ko02020,map02020 ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1,8.A.1.2.1 Bacteria 1MVAS@1224,2MRTA@213462,2WM5K@28221,42PKU@68525,COG0845@1,COG0845@2,COG3350@1,COG3350@2 NA|NA|NA M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family PFHLONEA_01799 1283300.ATXB01000002_gene3018 4.6e-08 65.5 Methylococcales cpoB 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 Bacteria 1MUSV@1224,1RQWA@1236,1XFEG@135618,COG1729@1,COG1729@2 NA|NA|NA D Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division PFHLONEA_01800 335543.Sfum_2435 4.5e-60 238.8 Deltaproteobacteria cebC Bacteria 1PCPQ@1224,2X5QT@28221,42Q6P@68525,COG1538@1,COG1538@2 NA|NA|NA MU Outer membrane efflux protein PFHLONEA_01801 667014.Thein_2065 5.9e-72 277.7 Thermodesulfobacteria ppdK 2.7.9.1,2.7.9.2 ko:K01006,ko:K01007 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173,M00374 R00199,R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 Bacteria 2GHHP@200940,COG0574@1,COG0574@2,COG3848@1,COG3848@2 NA|NA|NA GT Pyruvate phosphate dikinase, PEP/pyruvate binding domain PFHLONEA_01802 926562.Oweho_3009 2.7e-37 162.9 Bacteria 3.5.2.6 ko:K17836 ko00311,ko01130,ko01501,map00311,map01130,map01501 M00627,M00628 R06363 RC01499 ko00000,ko00001,ko00002,ko01000,ko01504 Bacteria COG2367@1,COG2367@2 NA|NA|NA V Beta-lactamase PFHLONEA_01803 926562.Oweho_3009 2.4e-40 172.9 Bacteria 3.5.2.6 ko:K17836 ko00311,ko01130,ko01501,map00311,map01130,map01501 M00627,M00628 R06363 RC01499 ko00000,ko00001,ko00002,ko01000,ko01504 Bacteria COG2367@1,COG2367@2 NA|NA|NA V Beta-lactamase PFHLONEA_01805 521011.Mpal_1139 6.4e-59 234.6 Methanomicrobia 1.5.99.15,1.6.5.3,1.8.4.10,1.8.4.8 ko:K00335,ko:K00390,ko:K18853 ko00190,ko00790,ko00920,ko01100,ko01120,map00190,map00790,map00920,map01100,map01120 M00144,M00176 R02021,R10802,R11945 RC00007,RC00061,RC01584,RC02862 ko00000,ko00001,ko00002,ko01000 3.D.1 Archaea 2NAWH@224756,2Y7JC@28890,COG2221@1,arCOG02059@2157 NA|NA|NA C Nitrite sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein PFHLONEA_01806 247490.KSU1_C0520 1.9e-84 318.9 Planctomycetes cysK GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 Bacteria 2IXCX@203682,COG0031@1,COG0031@2 NA|NA|NA E cysteine synthase PFHLONEA_01807 720554.Clocl_3813 1.5e-26 125.6 Ruminococcaceae ko:K21471 ko00000,ko01000,ko01002,ko01011 Bacteria 1V3ZU@1239,24JM4@186801,3WK89@541000,COG0739@1,COG0739@2 NA|NA|NA M Membrane proteins related to metalloendopeptidases PFHLONEA_01808 56780.SYN_00756 2.7e-70 272.3 Deltaproteobacteria lpxC GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0008654,GO:0008759,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 3.5.1.108,4.2.1.59 ko:K02535,ko:K16363 ko00061,ko00540,ko01100,ko01212,map00061,map00540,map01100,map01212 M00060,M00083 R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965 RC00166,RC00300,RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004,ko01005 iECS88_1305.ECS88_0100 Bacteria 1MV6T@1224,2WJ4I@28221,42MVM@68525,COG0774@1,COG0774@2 NA|NA|NA M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis PFHLONEA_01809 1125863.JAFN01000001_gene1608 2.1e-22 112.8 Deltaproteobacteria Bacteria 1N5BD@1224,2WQUR@28221,42U63@68525,COG0457@1,COG0457@2 NA|NA|NA S TPR repeat PFHLONEA_01810 207559.Dde_1182 2.3e-104 385.6 Desulfovibrionales appD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02031,ko:K02032,ko:K15269,ko:K15583 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 2.A.7.3.3,3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 1R4KB@1224,2M7V3@213115,2WJ32@28221,42M3F@68525,COG0444@1,COG0444@2 NA|NA|NA P Belongs to the ABC transporter superfamily PFHLONEA_01811 1499967.BAYZ01000105_gene3494 7.7e-108 397.1 Bacteria MA20_20675 ko:K02032,ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria COG4608@1,COG4608@2 NA|NA|NA P Belongs to the ABC transporter superfamily PFHLONEA_01814 909663.KI867150_gene72 6.4e-177 627.1 Syntrophobacterales rhlE 3.6.4.13 ko:K11927 ko03018,map03018 ko00000,ko00001,ko01000,ko03019 Bacteria 1MU49@1224,2MRD6@213462,2WIY6@28221,42MGZ@68525,COG0513@1,COG0513@2 NA|NA|NA L helicase superfamily c-terminal domain PFHLONEA_01815 269799.Gmet_0340 1.3e-25 121.7 Deltaproteobacteria cspA ko:K03704 ko00000,ko03000 Bacteria 1N6Q5@1224,2WR92@28221,42V0K@68525,COG1278@1,COG1278@2 NA|NA|NA K PFAM Cold-shock protein, DNA-binding PFHLONEA_01816 880072.Desac_2420 5.3e-153 547.7 Syntrophobacterales Bacteria 1PKG6@1224,2MQ8R@213462,2WJFI@28221,42MY4@68525,COG1924@1,COG1924@2,COG3580@1,COG3580@2,COG3581@1,COG3581@2 NA|NA|NA I BadF BadG BcrA BcrD PFHLONEA_01817 1041522.MCOL_V218691 2e-42 179.9 Bacteria Bacteria 2DVD7@1,33VCX@2 NA|NA|NA PFHLONEA_01818 237368.SCABRO_02247 9.6e-77 293.9 Planctomycetes ko:K07011 ko00000 Bacteria 2J0AR@203682,COG1216@1,COG1216@2 NA|NA|NA S Glycosyltransferase like family 2 PFHLONEA_01819 572477.Alvin_2609 1.9e-27 130.2 Chromatiales ko:K00754 ko00000,ko01000 GT4 Bacteria 1MU9C@1224,1RZRG@1236,1WVXI@135613,COG0438@1,COG0438@2 NA|NA|NA M glycosyl transferase group 1 PFHLONEA_01820 443144.GM21_3410 8.4e-50 204.5 Bacteria Bacteria COG0438@1,COG0438@2 NA|NA|NA M transferase activity, transferring glycosyl groups PFHLONEA_01821 1382359.JIAL01000001_gene2751 7.9e-63 247.3 Acidobacteriia ko:K12984 ko00000,ko01000,ko01003,ko01005,ko02000 4.D.1.3 GT2 Bacteria 2JIGQ@204432,3Y34G@57723,COG0463@1,COG0463@2 NA|NA|NA M PFAM Glycosyl transferase family 2 PFHLONEA_01822 316067.Geob_2111 2e-128 465.7 Desulfuromonadales ko:K02843,ko:K02849 ko00540,ko01100,map00540,map01100 M00080 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 GT9 Bacteria 1MXA2@1224,2WJNJ@28221,42NEW@68525,43S6D@69541,COG0859@1,COG0859@2 NA|NA|NA M Glycosyltransferase family 9 (heptosyltransferase) PFHLONEA_01823 1123376.AUIU01000016_gene303 2e-114 419.1 Nitrospirae obg GO:0000003,GO:0000160,GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007059,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019538,GO:0019954,GO:0022607,GO:0022611,GO:0022613,GO:0022618,GO:0023052,GO:0030436,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032991,GO:0034622,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0040007,GO:0042254,GO:0042255,GO:0043021,GO:0043022,GO:0043023,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043412,GO:0043933,GO:0043934,GO:0044085,GO:0044087,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090069,GO:0090071,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1990904 ko:K03979 ko00000,ko01000,ko03009 Bacteria 3J0E3@40117,COG0536@1,COG0536@2 NA|NA|NA S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control PFHLONEA_01824 555088.DealDRAFT_1008 2.1e-28 131.3 Syntrophomonadaceae rpmA GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904 ko:K02899 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V6HW@1239,24N3D@186801,42K0N@68298,COG0211@1,COG0211@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL27 family PFHLONEA_01825 177439.DP2592 5.2e-26 123.6 Desulfobacterales rplU GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02888 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1MZEW@1224,2MKN7@213118,2WQ3I@28221,42SGM@68525,COG0261@1,COG0261@2 NA|NA|NA J This protein binds to 23S rRNA in the presence of protein L20 PFHLONEA_01826 1499689.CCNN01000007_gene1724 3e-39 169.1 Clostridiaceae prmA ko:K02687 ko00000,ko01000,ko03009 Bacteria 1TPKI@1239,247VY@186801,36FBU@31979,COG2264@1,COG2264@2 NA|NA|NA J Ribosomal protein L11 methyltransferase PFHLONEA_01827 402777.KB235898_gene5792 1.1e-140 507.3 Oscillatoriales Bacteria 1G0SY@1117,1H7V4@1150,COG5001@1,COG5001@2 NA|NA|NA T signal transduction protein containing a membrane domain an EAL and a GGDEF domain PFHLONEA_01828 497964.CfE428DRAFT_4928 2.1e-175 622.5 Verrucomicrobia Bacteria 46SSZ@74201,COG0515@1,COG0515@2 NA|NA|NA KLT Serine/threonine phosphatases, family 2C, catalytic domain PFHLONEA_01829 497964.CfE428DRAFT_4929 5.7e-83 313.9 Bacteria yeeF GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006928,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008324,GO:0008519,GO:0009056,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015101,GO:0015203,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015489,GO:0015672,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0016020,GO:0022804,GO:0022857,GO:0022890,GO:0033554,GO:0034220,GO:0034641,GO:0040011,GO:0042402,GO:0044106,GO:0044237,GO:0044464,GO:0048870,GO:0050896,GO:0051179,GO:0051234,GO:0051674,GO:0051716,GO:0055085,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0072488,GO:0097164,GO:0098655,GO:0098660,GO:0098662,GO:1901564,GO:1901565,GO:1901575,GO:1902047,GO:1902600 ko:K14052 ko00000,ko02000 2.A.3.1.13 iSBO_1134.SBO_1766 Bacteria COG0531@1,COG0531@2 NA|NA|NA E amino acid PFHLONEA_01831 289376.THEYE_A0862 7.7e-225 786.6 Nitrospirae ilvD GO:0003674,GO:0003824,GO:0004160,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.9 ko:K01687,ko:K16786 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00770,map01100,map01110,map01130,map01210,map01230,map02010 M00019,M00570,M00582 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 iAF987.Gmet_1259,iECIAI39_1322.ECIAI39_3015 Bacteria 3J0ES@40117,COG0129@1,COG0129@2 NA|NA|NA EG Dehydratase family PFHLONEA_01833 555079.Toce_1892 1.5e-24 119.4 Thermoanaerobacterales rimI 2.3.1.128 ko:K03789,ko:K14742 ko00000,ko01000,ko03009,ko03016 Bacteria 1V6KU@1239,24J9Z@186801,42G5T@68295,COG0454@1,COG0456@2 NA|NA|NA K This enzyme acetylates the N-terminal alanine of ribosomal protein S18 PFHLONEA_01834 671143.DAMO_1553 9e-50 203.8 unclassified Bacteria yeaZ GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 ko:K01409,ko:K14742 R10648 RC00070,RC00416 ko00000,ko01000,ko03016 Bacteria 2NPK8@2323,COG1214@1,COG1214@2 NA|NA|NA O Glycoprotease family PFHLONEA_01836 688270.Celal_4040 1.4e-18 100.1 Cellulophaga Bacteria 1F9ZM@104264,1I5C7@117743,2CRK8@1,32SP8@2,4NWA3@976 NA|NA|NA S Domain of unknown function (DUF4253) PFHLONEA_01837 1123371.ATXH01000008_gene272 1.3e-177 629.4 Thermodesulfobacteria yngH 6.3.4.14,6.4.1.2,6.4.1.3,6.4.1.4 ko:K01961,ko:K01965,ko:K01968 ko00061,ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00036,M00082,M00373,M00376,M00741 R00742,R01859,R04138,R04385 RC00040,RC00097,RC00253,RC00367,RC00609,RC00942 ko00000,ko00001,ko00002,ko01000 Bacteria 2GH0C@200940,COG0439@1,COG0439@2 NA|NA|NA I Biotin carboxylase C-terminal domain PFHLONEA_01838 383372.Rcas_2954 2.7e-307 1060.8 Chloroflexia 6.4.1.1 ko:K01958 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 Bacteria 2GBN8@200795,376ZR@32061,COG1038@1,COG1038@2 NA|NA|NA C Conserved carboxylase domain PFHLONEA_01840 1123376.AUIU01000011_gene979 2e-54 219.5 Bacteria Bacteria COG0589@1,COG0589@2 NA|NA|NA T AMP binding PFHLONEA_01841 289376.THEYE_A0707 1.5e-127 463.0 Bacteria ko:K02584,ko:K07713 ko02020,map02020 M00499 ko00000,ko00001,ko00002,ko02022,ko03000 Bacteria COG2204@1,COG2204@2 NA|NA|NA T phosphorelay signal transduction system PFHLONEA_01843 289376.THEYE_A0727 3.3e-29 135.6 Bacteria ko:K03710 ko00000,ko03000 Bacteria COG2188@1,COG2188@2 NA|NA|NA K DNA-binding transcription factor activity PFHLONEA_01844 880072.Desac_2535 1.7e-28 132.5 Deltaproteobacteria Bacteria 1MVPE@1224,2WJCG@28221,42Q17@68525,COG2855@1,COG2855@2 NA|NA|NA S Conserved hypothetical protein 698 PFHLONEA_01845 1123376.AUIU01000013_gene1910 3.7e-15 86.7 Bacteria Bacteria 2EQ37@1,33HPJ@2 NA|NA|NA PFHLONEA_01846 880072.Desac_0514 7.5e-71 273.9 Syntrophobacterales terC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 1QZU6@1224,2MQEU@213462,2WNNS@28221,42S1Q@68525,COG0861@1,COG0861@2 NA|NA|NA P PFAM Integral membrane protein TerC PFHLONEA_01847 706587.Desti_1076 4.6e-66 258.1 Syntrophobacterales Bacteria 1R4GX@1224,2MRNW@213462,2X6GW@28221,42QKV@68525,COG1102@1,COG1102@2 NA|NA|NA F Cytidylate kinase-like family PFHLONEA_01848 1499967.BAYZ01000186_gene3978 1.2e-148 534.3 unclassified Bacteria ko:K03641 ko00000,ko02000 2.C.1.2 Bacteria 2NRA2@2323,COG0823@1,COG0823@2,COG4775@1,COG4775@2 NA|NA|NA MU WD40-like Beta Propeller Repeat PFHLONEA_01849 156889.Mmc1_0977 1.4e-66 260.0 Alphaproteobacteria nueM 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 R11945 RC00061 ko00000,ko00001,ko01000 Bacteria 1MW54@1224,2TQMD@28211,COG0702@1,COG0702@2 NA|NA|NA GM 3-beta hydroxysteroid dehydrogenase PFHLONEA_01850 555079.Toce_0372 9e-33 147.9 Thermoanaerobacterales Bacteria 1TQIK@1239,249Y6@186801,42FQY@68295,COG2199@1,COG2203@1,COG2203@2,COG3706@2 NA|NA|NA T Diguanylate cyclase with GAF sensor PFHLONEA_01853 443144.GM21_2638 4.9e-68 264.2 Desulfuromonadales fdnG GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008430,GO:0009055,GO:0009061,GO:0009326,GO:0009987,GO:0015942,GO:0015944,GO:0015980,GO:0016491,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0030151,GO:0030288,GO:0030313,GO:0031975,GO:0032787,GO:0032991,GO:0033554,GO:0036397,GO:0042597,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046872,GO:0046914,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0052738,GO:0055114,GO:0071704,GO:1902494 1.17.1.9,1.17.5.3 ko:K00123,ko:K08348 ko00630,ko00680,ko01100,ko01120,ko01200,ko02020,map00630,map00680,map01100,map01120,map01200,map02020 R00519 RC02796 ko00000,ko00001,ko01000 5.A.3.2 iECW_1372.ECW_m4203,iECs_1301.ECs2078,iUMNK88_1353.UMNK88_1879,iWFL_1372.ECW_m4203,iYL1228.KPN_04190,iZ_1308.Z2236 Bacteria 1MW3N@1224,2WIWD@28221,43BJY@68525,43TK1@69541,COG0243@1,COG0243@2,COG3383@1,COG3383@2 NA|NA|NA C Molybdopterin oxidoreductase Fe4S4 domain PFHLONEA_01855 443143.GM18_1046 1.8e-84 318.9 Proteobacteria 1.5.1.40 ko:K06988 ko00000,ko01000 Bacteria 1RCXR@1224,COG2085@1,COG2085@2 NA|NA|NA S nadp oxidoreductase, coenzyme f420-dependent PFHLONEA_01856 56780.SYN_02721 7.9e-135 487.3 Syntrophobacterales 3.1.3.3 ko:K07315 ko00000,ko01000,ko03021 Bacteria 1RAQS@1224,2MSKQ@213462,2X71A@28221,42MEJ@68525,COG2206@1,COG2206@2,COG5000@1,COG5000@2 NA|NA|NA T HD domain PFHLONEA_01857 316067.Geob_2397 6.3e-12 77.8 Desulfuromonadales Bacteria 1P6KE@1224,2BX4M@1,2WYFI@28221,2ZKVT@2,4331W@68525,43VNM@69541 NA|NA|NA PFHLONEA_01858 289376.THEYE_A1837 1.8e-59 235.7 Nitrospirae rdgB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66,5.1.1.3 ko:K01776,ko:K02428 ko00230,ko00471,ko01100,map00230,map00471,map01100 R00260,R00426,R00720,R01855,R02100,R02720,R03531 RC00002,RC00302 ko00000,ko00001,ko01000,ko01011 iAF987.Gmet_1875 Bacteria 3J0ST@40117,COG0127@1,COG0127@2 NA|NA|NA F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions PFHLONEA_01859 289376.THEYE_A1836 2.7e-85 321.6 Nitrospirae adk 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 3J0K3@40117,COG0563@1,COG0563@2 NA|NA|NA F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism PFHLONEA_01862 1158318.ATXC01000002_gene1601 2.7e-47 194.9 Aquificae argH GO:0003674,GO:0003824,GO:0004042,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016043,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0040007,GO:0042450,GO:0042802,GO:0042803,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,4.3.2.1 ko:K00619,ko:K14681 ko00220,ko00250,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map01100,map01110,map01130,map01210,map01230 M00028,M00029,M00844 R00259,R01086 RC00004,RC00064,RC00445,RC00447 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_0946 Bacteria 2G4ZU@200783,COG1246@1,COG1246@2 NA|NA|NA E Acetyltransferase (GNAT) domain PFHLONEA_01863 1121430.JMLG01000001_gene2284 3.6e-80 305.4 Peptococcaceae hemN GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 Bacteria 1TPES@1239,247P8@186801,260TE@186807,COG0635@1,COG0635@2 NA|NA|NA H Involved in the biosynthesis of porphyrin-containing compound PFHLONEA_01864 289376.THEYE_A0094 5.3e-155 555.1 Nitrospirae bamA GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 ko:K07277 ko00000,ko02000,ko03029 1.B.33 Bacteria 3J0AC@40117,COG4775@1,COG4775@2 NA|NA|NA M Surface antigen PFHLONEA_01865 330214.NIDE3042 8.9e-08 63.9 Nitrospirae ompH ko:K06142 ko00000 Bacteria 3J1AH@40117,COG2825@1,COG2825@2 NA|NA|NA M Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology PFHLONEA_01866 671143.DAMO_2848 8.6e-162 576.6 unclassified Bacteria guaB GO:0003674,GO:0003824,GO:0003938,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 iAPECO1_1312.APECO1_4018,iECABU_c1320.ECABU_c28100,iECP_1309.ECP_2510,iECSF_1327.ECSF_2349,iUTI89_1310.UTI89_C2826,ic_1306.c3027 Bacteria 2NNX4@2323,COG0516@1,COG0516@2,COG0517@1,COG0517@2 NA|NA|NA F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth PFHLONEA_01868 1123400.KB904789_gene234 2.5e-19 100.9 Gammaproteobacteria Bacteria 1R3P4@1224,1T6AF@1236,2BZQB@1,32Y98@2 NA|NA|NA PFHLONEA_01871 398767.Glov_0546 3.9e-12 78.2 Deltaproteobacteria ko:K09005 ko00000 Bacteria 1R507@1224,2WQ0C@28221,42NQA@68525,COG4393@1,COG4393@2 NA|NA|NA S Predicted membrane protein (DUF2318) PFHLONEA_01872 589865.DaAHT2_2403 1.9e-17 95.1 Deltaproteobacteria Bacteria 1P70I@1224,2DG9R@1,2WX9H@28221,2ZV2B@2,432AA@68525 NA|NA|NA PFHLONEA_01873 589865.DaAHT2_2402 1e-90 340.1 Deltaproteobacteria Bacteria 1RGTJ@1224,293RH@1,2WNTI@28221,2ZR74@2,42RWW@68525 NA|NA|NA C Cytochrome c554 and c-prime PFHLONEA_01874 243231.GSU0793 4.6e-34 151.0 Deltaproteobacteria ko:K21601 ko00000,ko03000 Bacteria 1RID8@1224,2WPEE@28221,42SYX@68525,COG4314@1,COG4314@2 NA|NA|NA C NosL PFHLONEA_01875 760568.Desku_3015 2e-07 62.8 Peptococcaceae resA GO:0008150,GO:0009987,GO:0016043,GO:0017004,GO:0022607,GO:0034622,GO:0043933,GO:0044085,GO:0065003,GO:0071840 ko:K06196 ko00000,ko02000 5.A.1.2 Bacteria 1V7JP@1239,25ET7@186801,265GZ@186807,COG0526@1,COG0526@2 NA|NA|NA CO Thioredoxin-like PFHLONEA_01877 1397527.Q670_14575 2.5e-10 73.9 Oceanospirillales Bacteria 1QXK5@1224,1T3DJ@1236,1XRU6@135619,COG4447@1,COG4447@2 NA|NA|NA S cellulose binding PFHLONEA_01878 796606.BMMGA3_10990 2e-27 129.0 Bacillus resA GO:0008150,GO:0009987,GO:0016043,GO:0017004,GO:0022607,GO:0034622,GO:0043933,GO:0044085,GO:0065003,GO:0071840 Bacteria 1VAPY@1239,1ZPVW@1386,4HI6P@91061,COG0526@1,COG0526@2 NA|NA|NA CO Thiol-disulfide oxidoreductase which is required in disulfide reduction during c-type cytochrome synthesis. May accept reducing equivalents from CcdA, leading to breakage of disulfide bonds in apocytochrome c PFHLONEA_01881 663610.JQKO01000003_gene1495 1.4e-25 123.2 Beijerinckiaceae Bacteria 1RGGR@1224,2U8HC@28211,3NCD4@45404,COG1136@1,COG1136@2 NA|NA|NA V (ABC) transporter PFHLONEA_01882 1279019.ARQK01000048_gene103 3.5e-15 88.6 Bacteria Bacteria COG1136@1,COG1136@2 NA|NA|NA V lipoprotein transporter activity PFHLONEA_01884 1313421.JHBV01000005_gene4581 1.5e-60 239.6 Sphingobacteriia macB ko:K02003 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 1IQ8R@117747,4NE5N@976,COG1136@1,COG1136@2 NA|NA|NA V ABC transporter PFHLONEA_01885 1255043.TVNIR_2757 2.2e-107 396.0 Gammaproteobacteria VPA0017 ko:K02004,ko:K09808 ko02010,map02010 M00255,M00258 ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.125 Bacteria 1R1KM@1224,1T554@1236,COG4591@1,COG4591@2 NA|NA|NA M MacB-like periplasmic core domain PFHLONEA_01886 608538.HTH_1022 5.5e-63 247.7 Aquificae ko:K02003,ko:K09810 ko02010,map02010 M00255,M00258 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.125 Bacteria 2G3W9@200783,COG1136@1,COG1136@2 NA|NA|NA V ABC transporter PFHLONEA_01887 1255043.TVNIR_2759 8.4e-112 410.6 Gammaproteobacteria ko:K02004 M00258 ko00000,ko00002,ko02000 3.A.1 Bacteria 1R5BD@1224,1S8BS@1236,COG0577@1,COG0577@2 NA|NA|NA V FtsX-like permease family PFHLONEA_01888 1255043.TVNIR_2760 4.5e-58 230.7 Proteobacteria Bacteria 1R69Q@1224,COG3391@1,COG3391@2 NA|NA|NA S amine dehydrogenase activity PFHLONEA_01889 671143.DAMO_1662 1.3e-27 130.2 Bacteria Bacteria COG3794@1,COG3794@2 NA|NA|NA C PFAM blue (type 1) copper domain protein PFHLONEA_01890 1185652.USDA257_c56640 3.4e-36 158.7 Alphaproteobacteria Bacteria 1RHQU@1224,2UBHY@28211,COG3794@1,COG3794@2 NA|NA|NA C PFAM blue (type 1) copper domain protein PFHLONEA_01891 666685.R2APBS1_1015 4.1e-16 92.8 Xanthomonadales 1.16.9.1 ko:K20150 ko00000,ko01000 Bacteria 1QCH9@1224,1S04D@1236,1X4XF@135614,28JQB@1,2Z9G8@2 NA|NA|NA PFHLONEA_01892 1049564.TevJSym_ac00600 1.5e-117 430.3 Bacteria 1.10.3.14 ko:K00425,ko:K08738 ko00190,ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00190,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00153,M00595 R10151,R11325 RC00061,RC03151,RC03152 ko00000,ko00001,ko00002,ko01000 3.D.4.3,3.D.4.6 Bacteria COG1271@1,COG1271@2 NA|NA|NA C aerobic electron transport chain PFHLONEA_01893 247490.KSU1_B0267 6.5e-13 80.9 Planctomycetes ko:K02305 ko00910,ko01120,map00910,map01120 M00529 R00294 RC02794 ko00000,ko00001,ko00002 3.D.4.10 Bacteria 2IXPN@203682,COG2010@1,COG2010@2 NA|NA|NA C Cytochrome c PFHLONEA_01894 1049564.TevJSym_ac00580 1.1e-40 173.7 Gammaproteobacteria Bacteria 1R28S@1224,1T5JD@1236,COG2010@1,COG2010@2 NA|NA|NA C Cytochrome c PFHLONEA_01896 555088.DealDRAFT_0314 3.4e-40 171.4 Syntrophomonadaceae ysnB ko:K07095 ko00000 Bacteria 1VA0U@1239,24MMK@186801,42K6X@68298,COG0622@1,COG0622@2 NA|NA|NA S Calcineurin-like phosphoesterase superfamily domain PFHLONEA_01897 338963.Pcar_1041 4.3e-127 461.5 Desulfuromonadales hisS 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 1MV2K@1224,2WJE1@28221,42MG0@68525,43SAP@69541,COG0124@1,COG0124@2 NA|NA|NA J Histidyl-tRNA synthetase PFHLONEA_01899 1265505.ATUG01000001_gene3109 7.5e-10 69.7 Desulfobacterales rsbU 3.1.3.3,4.6.1.1 ko:K01079,ko:K01768,ko:K07315 ko00230,ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,ko02025,ko04113,ko04213,map00230,map00260,map00680,map01100,map01120,map01130,map01200,map01230,map02025,map04113,map04213 M00020,M00695 R00089,R00434,R00582 RC00017,RC00295 ko00000,ko00001,ko00002,ko01000,ko01009,ko03021 Bacteria 1MXJQ@1224,2MIMK@213118,2WIJ4@28221,42MFQ@68525,COG2203@1,COG2203@2,COG2208@1,COG2208@2 NA|NA|NA T Stage II sporulation protein E (SpoIIE) PFHLONEA_01900 316067.Geob_0885 2.7e-129 468.8 Deltaproteobacteria htpX_2 3.4.24.84 ko:K06013 ko00900,ko01130,map00900,map01130 R09845 RC00141 ko00000,ko00001,ko01000,ko01002,ko04147 Bacteria 1MUXT@1224,2WKJ2@28221,42P1M@68525,COG0501@1,COG0501@2 NA|NA|NA O PFAM peptidase M48 Ste24p PFHLONEA_01901 406124.ACPC01000041_gene2332 2.7e-16 92.4 Bacillus vraR ko:K07694,ko:K11618 ko02020,map02020 M00480,M00481,M00754 ko00000,ko00001,ko00002,ko02022 Bacteria 1TQ1U@1239,1ZAT4@1386,4HA4B@91061,COG2197@1,COG2197@2 NA|NA|NA KT COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain PFHLONEA_01902 555079.Toce_0738 9.6e-45 186.8 Thermoanaerobacterales maf ko:K06287 ko00000 Bacteria 1V6FH@1239,24JRN@186801,42GIM@68295,COG0424@1,COG0424@2 NA|NA|NA D Maf-like protein PFHLONEA_01903 159087.Daro_1897 7e-177 627.5 Betaproteobacteria 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 Bacteria 1MUB8@1224,2VH1F@28216,COG3437@1,COG3437@2,COG4252@1,COG4252@2 NA|NA|NA T metal-dependent phosphohydrolase, HD sub domain PFHLONEA_01904 909663.KI867150_gene268 1.7e-246 858.6 Syntrophobacterales kup GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662 ko:K03549 ko00000,ko02000 2.A.72 Bacteria 1MUVH@1224,2MQ9X@213462,2WJEH@28221,42P5Y@68525,COG3158@1,COG3158@2 NA|NA|NA P Transport of potassium into the cell PFHLONEA_01905 485916.Dtox_0166 4.5e-09 66.6 Peptococcaceae tatA GO:0008150,GO:0040007 ko:K03116 ko03060,ko03070,map03060,map03070 M00336 ko00000,ko00001,ko00002,ko02044 2.A.64 Bacteria 1TV3X@1239,259BA@186801,2639X@186807,COG1826@1,COG1826@2 NA|NA|NA U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system PFHLONEA_01907 639282.DEFDS_1980 3.6e-212 744.6 Deferribacteres nuoF-1 1.12.1.3,1.6.5.3 ko:K00335,ko:K18331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 2GF0Z@200930,COG1894@1,COG1894@2 NA|NA|NA C PFAM Respiratory-chain NADH dehydrogenase domain 51 kDa subunit PFHLONEA_01908 555779.Dthio_PD3232 9.3e-46 189.9 Desulfovibrionales bamG 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 1RHBU@1224,2MAD2@213115,2WQ8V@28221,42U8S@68525,COG1905@1,COG1905@2 NA|NA|NA C Thioredoxin-like [2Fe-2S] ferredoxin PFHLONEA_01909 429009.Adeg_0336 2e-236 825.5 Thermoanaerobacterales cdhC 2.3.1.169 ko:K00193,ko:K14138 ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200 M00357,M00377,M00422 R08433,R09096,R10219,R10243 RC00004,RC00113,RC01144,RC02963,RC02964,RC02977 ko00000,ko00001,ko00002,ko01000 Bacteria 1TSWZ@1239,248Y2@186801,42EW2@68295,COG1614@1,COG1614@2 NA|NA|NA C CO dehydrogenase acetyl-CoA synthase complex beta subunit PFHLONEA_01910 289376.THEYE_A1471 3.3e-125 455.3 Bacteria acsC 2.1.1.245 ko:K00197 ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200 M00357,M00377,M00422 R09096,R10219,R10243 RC00004,RC00113,RC02977 ko00000,ko00001,ko00002,ko01000 Bacteria COG1456@1,COG1456@2 NA|NA|NA C acetyl-CoA catabolic process PFHLONEA_01911 1123376.AUIU01000011_gene1087 9.6e-14 82.4 Bacteria acsD 1.2.7.4,2.1.1.245 ko:K00194,ko:K00198 ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200 M00357,M00377,M00422 R07157,R08034,R09096,R10219,R10243 RC00004,RC00113,RC00250,RC02800,RC02977 ko00000,ko00001,ko00002,ko01000 Bacteria COG2069@1,COG2069@2 NA|NA|NA C one-carbon metabolic process PFHLONEA_01912 316067.Geob_3588 1.2e-142 513.1 Desulfuromonadales tyrS GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006437,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 iJN746.PP_0436,iLJ478.TM0478 Bacteria 1MVUQ@1224,2WIP6@28221,42N2A@68525,43TMJ@69541,COG0162@1,COG0162@2 NA|NA|NA J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) PFHLONEA_01913 562970.Btus_1798 6.2e-18 97.1 Alicyclobacillaceae cbiX 4.99.1.3,4.99.1.4 ko:K02006,ko:K03794,ko:K03795 ko00860,ko01100,ko01110,ko01120,ko02010,map00860,map01100,map01110,map01120,map02010 M00121,M00245,M00246 R02864,R05807 RC01012 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 Bacteria 1TRDV@1239,278MT@186823,4HQSK@91061,COG2138@1,COG2138@2 NA|NA|NA S CbiX PFHLONEA_01914 1232410.KI421416_gene2597 3.9e-77 295.0 Desulfuromonadales ribF 2.7.1.26,2.7.7.2 ko:K07011,ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS06310 Bacteria 1MV9I@1224,2WJTU@28221,42MV7@68525,43S5P@69541,COG0196@1,COG0196@2 NA|NA|NA H TIGRFAM riboflavin biosynthesis protein RibF PFHLONEA_01915 1232410.KI421416_gene2600 3.6e-108 398.7 Desulfuromonadales Bacteria 1NPPY@1224,2WKNX@28221,42NTB@68525,43U98@69541,COG4198@1,COG4198@2 NA|NA|NA S Protein of unknown function (DUF1015) PFHLONEA_01916 1009370.ALO_11594 2.1e-132 478.8 Negativicutes gap 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 Bacteria 1TNYU@1239,4H298@909932,COG0057@1,COG0057@2 NA|NA|NA C Belongs to the glyceraldehyde-3-phosphate dehydrogenase family PFHLONEA_01917 289376.THEYE_A0247 3.8e-157 561.2 Nitrospirae pgk GO:0003674,GO:0003824,GO:0004618,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.2.3,5.3.1.1 ko:K00927,ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01015,R01512 RC00002,RC00043,RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 3J0DE@40117,COG0126@1,COG0126@2 NA|NA|NA G Phosphoglycerate kinase PFHLONEA_01918 264732.Moth_0264 1.7e-78 299.3 Thermoanaerobacterales tpiA GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1TP2F@1239,248JN@186801,42FAI@68295,COG0149@1,COG0149@2 NA|NA|NA G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) PFHLONEA_01919 644282.Deba_1969 1e-16 92.8 Deltaproteobacteria secG GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 Bacteria 1NJ1D@1224,2WRA3@28221,42TKW@68525,COG1314@1,COG1314@2 NA|NA|NA U PFAM Preprotein translocase SecG subunit PFHLONEA_01920 243231.GSU1433 5.4e-181 641.0 Desulfuromonadales appA ko:K02035 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 1MUZH@1224,2WKBU@28221,42MFK@68525,43U0I@69541,COG0747@1,COG0747@2 NA|NA|NA E PFAM extracellular solute-binding protein, family 5 PFHLONEA_01921 1382306.JNIM01000001_gene660 4.6e-100 371.3 Chloroflexi ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2G5RD@200795,COG1131@1,COG1131@2 NA|NA|NA V PFAM ABC transporter related PFHLONEA_01922 1121472.AQWN01000010_gene533 1.1e-61 243.4 Peptococcaceae pedC ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 1UYEB@1239,24BUQ@186801,261NQ@186807,COG0842@1,COG0842@2 NA|NA|NA V Transport permease protein PFHLONEA_01923 330214.NIDE1215 1.3e-121 443.0 Nitrospirae hemE GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_0016 Bacteria 3J0C3@40117,COG0407@1,COG0407@2 NA|NA|NA H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III PFHLONEA_01924 316067.Geob_1076 1.5e-48 199.9 Desulfuromonadales hemH GO:0003674,GO:0003824,GO:0004325,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051540,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 Bacteria 1MVR1@1224,2WMJ2@28221,42M0C@68525,43TS8@69541,COG0276@1,COG0276@2 NA|NA|NA H Catalyzes the ferrous insertion into protoporphyrin IX PFHLONEA_01925 246194.CHY_0481 5.4e-110 404.8 Clostridia hemY 1.3.3.15,1.3.3.4 ko:K00231 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03222,R04178 RC00885 ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS09325 Bacteria 1TQ6W@1239,24IHQ@186801,COG1232@1,COG1232@2 NA|NA|NA H Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX PFHLONEA_01926 289376.THEYE_A0945 1.5e-35 156.0 Nitrospirae rfaF 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527,ko:K02841,ko:K02843,ko:K12982 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 GT30,GT9 Bacteria 3J0KI@40117,COG0859@1,COG0859@2 NA|NA|NA M Glycosyltransferase family 9 (heptosyltransferase) PFHLONEA_01929 29581.BW37_01163 1.3e-42 179.9 Betaproteobacteria nosD ko:K07218 ko00000 Bacteria 1MVCD@1224,2VIYN@28216,COG3420@1,COG3420@2 NA|NA|NA P Periplasmic copper-binding PFHLONEA_01930 338969.Rfer_3201 4.4e-65 255.0 Comamonadaceae nosF ko:K01990,ko:K19340 ko02010,map02010 M00254,M00762 ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.132.2 Bacteria 1MUX3@1224,2VKGA@28216,4ABF7@80864,COG1131@1,COG1131@2 NA|NA|NA V PFAM ABC transporter related PFHLONEA_01931 887898.HMPREF0551_2640 6.6e-28 130.6 Burkholderiaceae nosY ko:K19341 ko02010,map02010 M00762 ko00000,ko00001,ko00002,ko02000 3.A.1.132.2 Bacteria 1K3DW@119060,1MWUZ@1224,2VJDE@28216,COG1277@1,COG1277@2 NA|NA|NA S ABC-2 family transporter protein PFHLONEA_01932 404380.Gbem_2329 5.1e-119 434.1 Desulfuromonadales purF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009507,GO:0009536,GO:0040007,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 iSB619.SA_RS05225 Bacteria 1MU0V@1224,2WITV@28221,42MDB@68525,43UES@69541,COG0034@1,COG0034@2 NA|NA|NA F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine PFHLONEA_01934 1121428.DESHY_60117___1 2.6e-92 345.1 Peptococcaceae 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1UZ67@1239,247Q7@186801,2613R@186807,COG1013@1,COG1013@2 NA|NA|NA C PFAM Thiamine pyrophosphate PFHLONEA_01935 1121430.JMLG01000003_gene540 7.1e-50 203.8 Peptococcaceae 1.2.7.3,1.2.7.7 ko:K00177,ko:K00187 ko00020,ko00280,ko00720,ko01100,ko01120,ko01200,map00020,map00280,map00720,map01100,map01120,map01200 M00009,M00011,M00173,M00620 R01197,R07160,R08566,R08567 RC00004,RC02833,RC02856 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1UYYG@1239,24I53@186801,261KE@186807,COG1014@1,COG1014@2 NA|NA|NA C TIGRFAM 2-oxoacid acceptor oxidoreductase, gamma subunit, pyruvate 2-ketoisovalerate PFHLONEA_01936 289376.THEYE_A1473 5.2e-86 324.3 Nitrospirae metH 2.1.1.13,2.1.1.245,2.1.1.258 ko:K00197,ko:K00548,ko:K15023 ko00270,ko00450,ko00670,ko00680,ko00720,ko01100,ko01110,ko01120,ko01200,ko01230,map00270,map00450,map00670,map00680,map00720,map01100,map01110,map01120,map01200,map01230 M00017,M00357,M00377,M00422 R00946,R02289,R09096,R09365,R10219,R10243 RC00004,RC00035,RC00113,RC01144,RC01241,RC02871,RC02977 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0UH@40117,COG1410@1,COG1410@2 NA|NA|NA H Pterin binding enzyme PFHLONEA_01937 555779.Dthio_PD3219 7.9e-67 260.8 Deltaproteobacteria Bacteria 1RBEZ@1224,2WPBQ@28221,42PJR@68525,COG5495@1,COG5495@2 NA|NA|NA S Domain of unknown function (DUF2520) PFHLONEA_01938 1125863.JAFN01000001_gene2547 1e-70 273.5 Deltaproteobacteria acsF ko:K07321 ko00000 Bacteria 1R819@1224,2WKE4@28221,42PQR@68525,COG3640@1,COG3640@2 NA|NA|NA D PFAM Cobyrinic acid a,c-diamide synthase PFHLONEA_01939 289376.THEYE_A0969 1.9e-82 312.4 Bacteria thyX 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 R06613 RC00022,RC00332 ko00000,ko00001,ko01000 Bacteria COG1351@1,COG1351@2 NA|NA|NA F thymidylate synthase (FAD) activity PFHLONEA_01940 370438.PTH_0220 1e-89 336.7 Peptococcaceae panB 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPZA@1239,248RR@186801,260CY@186807,COG0413@1,COG0413@2 NA|NA|NA H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate PFHLONEA_01941 96561.Dole_1151 1.5e-36 159.5 Desulfobacterales metF3 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 Bacteria 1MXTZ@1224,2MJC0@213118,2WK04@28221,42NTS@68525,COG0685@1,COG0685@2 NA|NA|NA E PFAM Methylenetetrahydrofolate reductase PFHLONEA_01942 1267535.KB906767_gene2422 1.5e-16 92.4 Bacteria Bacteria COG3055@1,COG3055@2 NA|NA|NA G Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses PFHLONEA_01945 765911.Thivi_1063 3.2e-61 242.7 Chromatiales pqiA1 ko:K03808 ko00000 Bacteria 1R864@1224,1T67W@1236,1WXD3@135613,COG2995@1,COG2995@2 NA|NA|NA S Paraquat-inducible protein A PFHLONEA_01947 1232410.KI421421_gene3284 9.2e-36 157.5 Deltaproteobacteria yeiR GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0008270,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0043167,GO:0043169,GO:0046872,GO:0046914 ko:K07089 ko00000 Bacteria 1MVZV@1224,2WR5K@28221,42UA6@68525,COG0523@1,COG0523@2 NA|NA|NA S cobalamin synthesis protein, P47K PFHLONEA_01948 880073.Calab_2887 8.5e-58 230.3 unclassified Bacteria ko:K02481,ko:K07714 ko02020,map02020 M00500 ko00000,ko00001,ko00002,ko02022 Bacteria 2NQHI@2323,COG2204@1,COG2204@2 NA|NA|NA T Sigma-54 interaction domain PFHLONEA_01949 671143.DAMO_2589 1.3e-45 189.9 Bacteria Bacteria COG0500@1,COG2226@2 NA|NA|NA Q methyltransferase PFHLONEA_01950 1538295.JY96_19505 7.8e-33 147.1 unclassified Burkholderiales norB GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016661,GO:0016662,GO:0016966,GO:0055114 1.7.2.5 ko:K04561 ko00910,ko01120,map00910,map01120 M00529 R00294 RC02794 ko00000,ko00001,ko00002,ko01000 3.D.4.10 Bacteria 1KJTB@119065,1MVT1@1224,2VHXU@28216,COG3256@1,COG3256@2 NA|NA|NA C Belongs to the heme-copper respiratory oxidase family PFHLONEA_01952 1125863.JAFN01000001_gene1462 3.9e-286 990.7 Deltaproteobacteria pacS GO:0000041,GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0008150,GO:0015677,GO:0016020,GO:0030001,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0051179,GO:0051234,GO:0071944 3.6.3.4,3.6.3.54 ko:K01533,ko:K17686 ko01524,ko04016,map01524,map04016 R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 Bacteria 1MU08@1224,2WJ4J@28221,42M2R@68525,COG2217@1,COG2217@2 NA|NA|NA P ATPase, P-type (transporting), HAD superfamily, subfamily IC PFHLONEA_01954 1304885.AUEY01000052_gene1549 9.3e-07 60.1 Bacteria Bacteria 2CCD9@1,2ZWK6@2 NA|NA|NA S YtkA-like PFHLONEA_01955 1217720.ALOX01000040_gene2917 5.1e-21 107.5 Rhodospirillales Bacteria 1QTTP@1224,2JR3G@204441,2TVY9@28211,COG0477@1,COG0477@2 NA|NA|NA EGP Major facilitator superfamily PFHLONEA_01956 1121926.AXWO01000003_gene669 8.8e-25 119.8 Glycomycetales ybhF_2 ko:K01990,ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2I2I7@201174,4EZ4U@85014,COG1131@1,COG1131@2 NA|NA|NA V ATPases associated with a variety of cellular activities PFHLONEA_01957 1120985.AUMI01000016_gene1763 4.6e-77 294.7 Negativicutes dtpT ko:K03305 ko00000 2.A.17 Bacteria 1TP81@1239,4H520@909932,COG3104@1,COG3104@2 NA|NA|NA E POT family PFHLONEA_01959 1382306.JNIM01000001_gene2504 6.9e-28 130.2 Bacteria Bacteria COG1917@1,COG1917@2 NA|NA|NA L Cupin 2, conserved barrel domain protein PFHLONEA_01961 1121423.JONT01000009_gene1515 3.1e-24 118.2 Peptococcaceae Bacteria 1TZ1N@1239,24CEW@186801,2636N@186807,COG2761@1,COG2761@2 NA|NA|NA Q DSBA-like thioredoxin domain PFHLONEA_01963 1254432.SCE1572_09215 6.7e-198 696.8 Myxococcales kdpB GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031004,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090533,GO:0090662,GO:0098533,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.12 ko:K01547 ko02020,map02020 ko00000,ko00001,ko01000 3.A.3.7 iAF987.Gmet_2434,iECNA114_1301.ECNA114_0634,iECSF_1327.ECSF_0632 Bacteria 1MU7D@1224,2WJC0@28221,2YWXY@29,42NGX@68525,COG2216@1,COG2216@2 NA|NA|NA P Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system PFHLONEA_01964 1234364.AMSF01000016_gene1734 4.6e-60 237.7 Xanthomonadales kdpC GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 ko:K01548 ko02020,map02020 ko00000,ko00001,ko01000 3.A.3.7 Bacteria 1RABG@1224,1S2B0@1236,1X6DA@135614,COG2156@1,COG2156@2 NA|NA|NA P Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex PFHLONEA_01966 1329516.JPST01000048_gene1880 6.1e-130 471.9 Thermoactinomycetaceae mutS2 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 ko:K07456 ko03430,map03430 ko00000,ko00001,ko03400 Bacteria 1TP5W@1239,27AZ8@186824,4H9NZ@91061,COG1193@1,COG1193@2 NA|NA|NA L Small MutS-related domain PFHLONEA_01967 289376.THEYE_A1027 4.8e-89 334.3 Bacteria Bacteria COG0327@1,COG0327@2 NA|NA|NA L Belongs to the GTP cyclohydrolase I type 2 NIF3 family PFHLONEA_01970 1158756.AQXQ01000008_gene2335 1.2e-22 113.6 Chromatiales cheW ko:K02659,ko:K03408 ko02020,ko02025,ko02030,map02020,map02025,map02030 ko00000,ko00001,ko02035,ko02044 Bacteria 1RAH1@1224,1SYDF@1236,1WXZ3@135613,COG0835@1,COG0835@2 NA|NA|NA NT PFAM CheW domain protein PFHLONEA_01972 861299.J421_2157 1.3e-141 510.8 Gemmatimonadetes 2.7.11.1 ko:K12132 ko00000,ko01000,ko01001 Bacteria 1ZUXK@142182,COG3629@1,COG3629@2,COG3899@1,COG3899@2 NA|NA|NA T AAA ATPase domain PFHLONEA_01978 1125863.JAFN01000001_gene2150 3.7e-19 100.9 Deltaproteobacteria cimA 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1MUNQ@1224,2WJC9@28221,42MAV@68525,COG0119@1,COG0119@2 NA|NA|NA E Belongs to the alpha-IPM synthase homocitrate synthase family PFHLONEA_01979 289376.THEYE_A1522 2.7e-158 565.1 Nitrospirae lysC GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.3,2.7.2.4 ko:K00928,ko:K12524 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480,R01773,R01775 RC00002,RC00043,RC00087 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0AZ@40117,COG0527@1,COG0527@2 NA|NA|NA E ACT domain PFHLONEA_01980 289376.THEYE_A1682 9.8e-137 493.4 Nitrospirae apgM 5.4.2.12 ko:K15635 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0YA@40117,COG3635@1,COG3635@2 NA|NA|NA G Metalloenzyme superfamily PFHLONEA_01981 289376.THEYE_A1680 8.8e-21 105.9 Nitrospirae ko:K02071 ko02010,map02010 M00238 ko00000,ko00001,ko00002,ko02000 3.A.1.24 Bacteria 3J0VT@40117,COG1135@1,COG1135@2 NA|NA|NA P NIL PFHLONEA_01982 289376.THEYE_A1679 8e-26 122.9 Nitrospirae 2.7.7.80,2.8.1.11 ko:K03636,ko:K21147 ko04122,map04122 R07459,R07461 RC00043 ko00000,ko00001,ko01000 Bacteria 3J0T2@40117,COG1977@1,COG1977@2 NA|NA|NA H ThiS family PFHLONEA_01983 1123376.AUIU01000013_gene1808 1.9e-164 585.5 Nitrospirae thrC1 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0FZ@40117,COG0498@1,COG0498@2 NA|NA|NA E Pyridoxal-phosphate dependent enzyme PFHLONEA_01984 59374.Fisuc_0166 3e-21 108.2 Bacteria mec 3.13.1.6 ko:K21140 ko04122,map04122 R11524 RC00064,RC00090 ko00000,ko00001,ko01000 Bacteria COG1310@1,COG1310@2 NA|NA|NA S proteolysis PFHLONEA_01985 1131269.AQVV01000007_gene999 2.2e-100 372.1 Bacteria moeB 2.7.7.80 ko:K21029 ko04122,map04122 R07459 RC00043 ko00000,ko00001,ko01000 Bacteria COG0476@1,COG0476@2 NA|NA|NA H Involved in molybdopterin and thiamine biosynthesis, family 2 PFHLONEA_01986 123214.PERMA_0128 3e-19 100.9 Aquificae 1.8.7.1 ko:K00392 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00859,R03600 RC00065 ko00000,ko00001,ko00002,ko01000 Bacteria 2G5AY@200783,COG0425@1,COG0425@2 NA|NA|NA O Belongs to the sulfur carrier protein TusA family PFHLONEA_01987 330214.NIDE4114 7.6e-151 540.4 Nitrospirae hom GO:0003674,GO:0003824,GO:0004412,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.3,2.2.1.6 ko:K00003,ko:K01653 ko00260,ko00270,ko00290,ko00300,ko00650,ko00660,ko00770,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00270,map00290,map00300,map00650,map00660,map00770,map01100,map01110,map01120,map01130,map01210,map01230 M00017,M00018,M00019,M00570 R00006,R00014,R00226,R01773,R01775,R03050,R04672,R04673,R08648 RC00027,RC00087,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv1294,iSB619.SA_RS06610 Bacteria 3J0G1@40117,COG0440@1,COG0440@2,COG0460@1,COG0460@2 NA|NA|NA E Homoserine dehydrogenase PFHLONEA_01988 1123376.AUIU01000015_gene436 6.3e-47 193.4 Nitrospirae yfdZ GO:0003674,GO:0003824,GO:0004021,GO:0006082,GO:0006090,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009078,GO:0009079,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019272,GO:0019752,GO:0030632,GO:0032787,GO:0042851,GO:0042852,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0047635,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.83 ko:K10206,ko:K14261 ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230 M00527 R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 iEcSMS35_1347.EcSMS35_2531,iSBO_1134.SBO_2405 Bacteria 3J0ED@40117,COG0436@1,COG0436@2 NA|NA|NA E Aminotransferase class I and II PFHLONEA_01992 398767.Glov_2384 1.1e-18 100.1 Proteobacteria Bacteria 1RK55@1224,2ATWF@1,31JFP@2 NA|NA|NA PFHLONEA_01993 706587.Desti_1873 1.1e-71 277.3 Syntrophobacterales ko:K07079 ko00000 Bacteria 1RAU3@1224,2MS7U@213462,2X9UN@28221,43A0M@68525,COG1453@1,COG1453@2 NA|NA|NA S PFAM aldo keto reductase PFHLONEA_01994 706587.Desti_1874 1.8e-26 126.7 Syntrophobacterales Bacteria 1NNEB@1224,2CK1R@1,2MSEY@213462,2X38Q@28221,32V4M@2,437YS@68525 NA|NA|NA PFHLONEA_01998 330214.NIDE0998 1.2e-58 232.6 Nitrospirae ilvH GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 iAPECO1_1312.APECO1_1906,iECNA114_1301.ECNA114_0072,iEcSMS35_1347.EcSMS35_0084,iG2583_1286.G2583_0082,iSFxv_1172.SFxv_0077,iUTI89_1310.UTI89_C0086 Bacteria 3J0K8@40117,COG0440@1,COG0440@2 NA|NA|NA E ACT domain PFHLONEA_01999 1123376.AUIU01000012_gene1590 8.1e-126 456.8 Nitrospirae ilvI GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030976,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 iAPECO1_1312.APECO1_1907,iB21_1397.B21_00078,iBWG_1329.BWG_0073,iECBD_1354.ECBD_3539,iECB_1328.ECB_00079,iECD_1391.ECD_00079,iUTI89_1310.UTI89_C0085,iYL1228.KPN_00082 Bacteria 3J0D6@40117,COG0028@1,COG0028@2 NA|NA|NA H Thiamine pyrophosphate enzyme, N-terminal TPP binding domain PFHLONEA_02004 1121918.ARWE01000001_gene738 1.3e-31 143.7 Desulfuromonadales gspC ko:K02452,ko:K02463 ko03070,ko05111,map03070,map05111 M00331 ko00000,ko00001,ko00002,ko02044 3.A.15 Bacteria 1PUWN@1224,2WR4E@28221,42T73@68525,43UXS@69541,COG3031@1,COG3031@2 NA|NA|NA U Type II secretion system protein C PFHLONEA_02005 290512.Paes_0081 4.4e-111 408.3 Chlorobi Bacteria 1FEII@1090,COG3547@1,COG3547@2 NA|NA|NA L transposase IS116 IS110 IS902 family protein PFHLONEA_02006 269799.Gmet_0141 6.7e-48 197.6 Bacteria Bacteria COG0755@1,COG0755@2 NA|NA|NA O cytochrome complex assembly PFHLONEA_02007 316067.Geob_3806 1.2e-31 143.7 Desulfuromonadales ccs1 ko:K07399 ko00000 Bacteria 1RIJF@1224,2WPA1@28221,42T2N@68525,43VTI@69541,COG1333@1,COG1333@2 NA|NA|NA O cytochrome c biogenesis protein PFHLONEA_02008 760568.Desku_2029 8.7e-86 323.9 Peptococcaceae mnmA 2.8.1.13 ko:K00566 ko04122,map04122 R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 Bacteria 1TPIZ@1239,247YV@186801,2608Q@186807,COG0482@1,COG0482@2 NA|NA|NA J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 PFHLONEA_02009 637389.Acaty_c2171 3e-45 189.1 Acidithiobacillales rbcR Bacteria 1MWVU@1224,1RPT8@1236,2NC29@225057,COG0583@1,COG0583@2 NA|NA|NA K Transcriptional regulator, LysR PFHLONEA_02010 643648.Slip_1758 1.6e-69 269.6 Syntrophomonadaceae tupA ko:K05772 ko02010,map02010 M00186 ko00000,ko00001,ko00002,ko02000 3.A.1.6.2,3.A.1.6.4 Bacteria 1TQA9@1239,249EZ@186801,42JT0@68298,COG2998@1,COG2998@2 NA|NA|NA H ABC-type tungstate transport system permease component-like protein PFHLONEA_02011 1123376.AUIU01000015_gene360 4.3e-99 367.9 Bacteria ko:K05772 ko02010,map02010 M00186 ko00000,ko00001,ko00002,ko02000 3.A.1.6.2,3.A.1.6.4 Bacteria COG2998@1,COG2998@2 NA|NA|NA H PBP superfamily domain PFHLONEA_02012 289376.THEYE_A0048 5.3e-74 284.3 Nitrospirae tupB 3.6.3.55 ko:K05773,ko:K06857 ko02010,map02010 M00186 R10531 RC00002 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.6.2,3.A.1.6.4 Bacteria 3J12J@40117,COG4662@1,COG4662@2 NA|NA|NA P Binding-protein-dependent transport system inner membrane component PFHLONEA_02013 1123376.AUIU01000015_gene362 6.4e-66 257.3 Bacteria gtsA 3.6.3.30,3.6.3.55 ko:K02010,ko:K02049,ko:K02068,ko:K02071,ko:K06857,ko:K10112 ko02010,map02010 M00186,M00188,M00190,M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00211,M00238,M00491,M00602,M00605,M00606 R10531 RC00002 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.1,3.A.1.10,3.A.1.16,3.A.1.17,3.A.1.24,3.A.1.6.2,3.A.1.6.4 Bacteria COG3842@1,COG3842@2 NA|NA|NA P ATPase activity PFHLONEA_02014 388739.RSK20926_02579 2.8e-16 91.3 Roseobacter Bacteria 1RG1P@1224,294D0@1,2P4FJ@2433,2UQ6D@28211,2ZRSZ@2 NA|NA|NA PFHLONEA_02016 330214.NIDE0989 6.3e-61 241.5 Nitrospirae dnaG GO:0003674,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090304,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 ko:K02316 ko03030,map03030 ko00000,ko00001,ko01000,ko03032 Bacteria 3J0IN@40117,COG0358@1,COG0358@2 NA|NA|NA L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication PFHLONEA_02017 370438.PTH_2521 1e-71 276.6 Peptococcaceae gatB GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.12,6.3.5.6,6.3.5.7 ko:K01876,ko:K02434 ko00970,ko01100,map00970,map01100 M00359,M00360 R03905,R04212,R05577 RC00010,RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 Bacteria 1TPG3@1239,247MS@186801,260XG@186807,COG0064@1,COG0064@2 NA|NA|NA J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) PFHLONEA_02018 1121405.dsmv_2046 1e-21 110.5 Desulfobacterales ppiD 5.2.1.8 ko:K01802,ko:K03769,ko:K03770 ko00000,ko01000,ko03110 Bacteria 1MWV0@1224,2MHM6@213118,2WJM1@28221,42MPK@68525,COG0760@1,COG0760@2 NA|NA|NA O PFAM PpiC-type peptidyl-prolyl cis-trans isomerase PFHLONEA_02019 1144275.COCOR_06542 2.5e-139 502.3 Myxococcales Bacteria 1MW20@1224,2WIRX@28221,2YUYT@29,42N09@68525,COG0624@1,COG0624@2 NA|NA|NA E Peptidase dimerisation domain PFHLONEA_02022 397287.C807_02969 1.3e-46 193.0 unclassified Lachnospiraceae flr_1 Bacteria 1V1EA@1239,24FWS@186801,27MEN@186928,COG1853@1,COG1853@2 NA|NA|NA S Flavin reductase like domain PFHLONEA_02023 1302286.BAOT01000023_gene1171 2.1e-32 146.0 Lactobacillaceae 2.5.1.105 ko:K04088,ko:K06897 ko00790,map00790 M00742 R10339 RC00121 ko00000,ko00001,ko00002,ko01000 Bacteria 1V9B6@1239,3F4M1@33958,4HJTJ@91061,COG0053@1,COG0053@2 NA|NA|NA P Cation efflux family PFHLONEA_02024 1123376.AUIU01000015_gene506 8e-23 112.5 Nitrospirae 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 Bacteria 3J13U@40117,COG1960@1,COG1960@2 NA|NA|NA C Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology PFHLONEA_02025 1123376.AUIU01000004_gene1163 4.6e-87 327.8 Bacteria etfB GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016020,GO:0016491,GO:0022900,GO:0030312,GO:0040007,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944 ko:K03521 ko00000 Bacteria COG2086@1,COG2086@2 NA|NA|NA C electron transfer activity PFHLONEA_02026 697281.Mahau_1319 4.1e-119 434.9 Thermoanaerobacterales fixB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0019395,GO:0019752,GO:0022900,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575 1.3.1.108 ko:K03522,ko:K22432 ko00000,ko01000,ko04147 iAF987.Gmet_2066,iAF987.Gmet_2257 Bacteria 1TPC8@1239,247NF@186801,42FKR@68295,COG2025@1,COG2025@2 NA|NA|NA C electron transfer flavoprotein, alpha subunit PFHLONEA_02027 273068.TTE1473 9.1e-90 337.0 Thermoanaerobacterales fabD 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 Bacteria 1TPB7@1239,247UF@186801,42EZH@68295,COG0331@1,COG0331@2 NA|NA|NA I malonyl coa-acyl carrier protein transacylase PFHLONEA_02028 330214.NIDE0797 9.4e-82 310.1 Nitrospirae Bacteria 3J0J6@40117,COG1028@1,COG1028@2 NA|NA|NA IQ Evidence 2a Function of homologous gene experimentally demonstrated in an other organism PFHLONEA_02029 639282.DEFDS_0153 2.8e-24 117.5 Deferribacteres acpP GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0050896,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 ko:K02078 ko00000,ko00001 Bacteria 2GG1C@200930,COG0236@1,COG0236@2 NA|NA|NA IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis PFHLONEA_02030 289376.THEYE_A0103 2.3e-162 578.6 Nitrospirae fabF GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0033817,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 iAF1260.b1095,iAPECO1_1312.APECO1_176,iB21_1397.B21_01099,iBWG_1329.BWG_0943,iE2348C_1286.E2348C_1187,iEC042_1314.EC042_1165,iEC55989_1330.EC55989_1207,iECABU_c1320.ECABU_c13085,iECBD_1354.ECBD_2506,iECB_1328.ECB_01091,iECDH10B_1368.ECDH10B_1167,iECDH1ME8569_1439.ECDH1ME8569_1030,iECD_1391.ECD_01091,iECED1_1282.ECED1_1238,iECH74115_1262.ECH74115_1474,iECIAI1_1343.ECIAI1_1130,iECIAI39_1322.ECIAI39_2066,iECO103_1326.ECO103_1140,iECO111_1330.ECO111_1372,iECO26_1355.ECO26_1428,iECOK1_1307.ECOK1_1202,iECP_1309.ECP_1087,iECS88_1305.ECS88_1109,iECSE_1348.ECSE_1159,iECSF_1327.ECSF_0994,iECSP_1301.ECSP_1396,iECUMN_1333.ECUMN_1270,iECW_1372.ECW_m1203,iECs_1301.ECs1473,iEKO11_1354.EKO11_2739,iETEC_1333.ETEC_1160,iEcDH1_1363.EcDH1_2552,iEcE24377_1341.EcE24377A_1216,iEcSMS35_1347.EcSMS35_2032,iG2583_1286.G2583_1355,iJO1366.b1095,iJR904.b1095,iLF82_1304.LF82_0607,iNRG857_1313.NRG857_05280,iSF_1195.SF1099,iSFxv_1172.SFxv_1251,iS_1188.S1179,iUMN146_1321.UM146_11850,iWFL_1372.ECW_m1203,iY75_1357.Y75_RS05720,iZ_1308.Z1734,ic_1306.c1365 Bacteria 3J0DH@40117,COG0304@1,COG0304@2 NA|NA|NA I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP PFHLONEA_02031 1162668.LFE_1933 8.4e-56 223.8 Nitrospirae rnc GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3,3.1.3.97 ko:K03685,ko:K07053 ko03008,ko05205,map03008,map05205 R00188,R11188 RC00078 ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 Bacteria 3J119@40117,COG0571@1,COG0571@2 NA|NA|NA J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism PFHLONEA_02032 1123371.ATXH01000003_gene1951 3.8e-90 339.3 Thermodesulfobacteria Bacteria 2GI6R@200940,COG3852@1,COG3852@2 NA|NA|NA T PAS domain PFHLONEA_02034 880072.Desac_1081 5.1e-24 117.1 Syntrophobacterales 4.1.1.44 ko:K01607 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 R03470 RC00938 ko00000,ko00001,ko01000 Bacteria 1N2ZQ@1224,2MSC8@213462,2WRKS@28221,42VDR@68525,COG0599@1,COG0599@2 NA|NA|NA S Carboxymuconolactone decarboxylase family PFHLONEA_02035 269799.Gmet_0861 5.3e-116 425.2 Deltaproteobacteria ko:K02652 ko00000,ko02035,ko02044 3.A.15.2 Bacteria 1MU7V@1224,2WM6A@28221,42P9Y@68525,COG2804@1,COG2804@2 NA|NA|NA NU General secretory system II protein E domain protein PFHLONEA_02036 1158345.JNLL01000001_gene1612 5.6e-65 254.6 Bacteria yfbL Bacteria COG2234@1,COG2234@2 NA|NA|NA DZ aminopeptidase activity PFHLONEA_02040 1487923.DP73_20920 1.1e-91 343.2 Peptococcaceae dsrO ko:K00184 ko00000 5.A.3 Bacteria 1UZKF@1239,24EM4@186801,263Y7@186807,COG0437@1,COG0437@2 NA|NA|NA C TIGRFAM Tat (twin-arginine translocation) pathway signal sequence PFHLONEA_02041 756499.Desde_0274 5.2e-143 514.2 Peptococcaceae dsrP ko:K00185 ko00000 5.A.3 Bacteria 1UYGM@1239,24EQA@186801,263KI@186807,COG5557@1,COG5557@2 NA|NA|NA C PFAM Polysulphide reductase, NrfD PFHLONEA_02042 747365.Thena_1364 1.4e-10 71.6 Clostridia MA20_14855 1.6.5.3 ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 1UJK8@1239,25F5P@186801,COG1146@1,COG1146@2 NA|NA|NA C 4Fe-4S single cluster domain PFHLONEA_02043 1379698.RBG1_1C00001G1759 1.7e-86 325.9 unclassified Bacteria qmcA Bacteria 2NNUC@2323,COG0330@1,COG0330@2 NA|NA|NA O prohibitin homologues PFHLONEA_02044 289376.THEYE_A0592 4.6e-107 394.8 Nitrospirae nfeD ko:K07403 ko00000 Bacteria 3J0WF@40117,COG1030@1,COG1030@2 NA|NA|NA O NfeD-like C-terminal, partner-binding PFHLONEA_02045 269799.Gmet_2348 1.7e-91 343.2 Desulfuromonadales kdtA GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 GT30 iECNA114_1301.ECNA114_3778,iIT341.HP0957,iUMNK88_1353.UMNK88_4417 Bacteria 1MU9F@1224,2WMQM@28221,42PCH@68525,43TBC@69541,COG1519@1,COG1519@2 NA|NA|NA M 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) PFHLONEA_02046 1379698.RBG1_1C00001G1645 6.4e-34 151.0 unclassified Bacteria MA20_05800 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527,ko:K09778 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 GT30 Bacteria 2NPP6@2323,COG2121@1,COG2121@2 NA|NA|NA S Domain of unknown function (DUF374) PFHLONEA_02047 56780.SYN_01564 3.7e-93 348.2 Syntrophobacterales msbA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0006869,GO:0008144,GO:0008150,GO:0008289,GO:0008559,GO:0009987,GO:0010876,GO:0015221,GO:0015238,GO:0015399,GO:0015405,GO:0015437,GO:0015893,GO:0015920,GO:0016020,GO:0016021,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0034040,GO:0034204,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042802,GO:0042908,GO:0042910,GO:0043167,GO:0043168,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0065007,GO:0065008,GO:0071702,GO:0071840,GO:0071944,GO:0097035,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901265,GO:1901363,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 ko:K02021,ko:K06147,ko:K11085 ko02010,map02010 ko00000,ko00001,ko01000,ko02000 3.A.1.106,3.A.1.109,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21 iJN746.PP_4935,iPC815.YPO1395,iUMN146_1321.UM146_12980 Bacteria 1MUBM@1224,2MQ69@213462,2WJ7M@28221,42M01@68525,COG1132@1,COG1132@2 NA|NA|NA V Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation PFHLONEA_02049 880073.Calab_2028 2.3e-87 328.9 unclassified Bacteria 1.1.1.31,1.1.1.60 ko:K00020,ko:K00042 ko00280,ko00630,ko01100,map00280,map00630,map01100 R01745,R01747,R05066 RC00099 ko00000,ko00001,ko01000 Bacteria 2NP96@2323,COG2084@1,COG2084@2 NA|NA|NA I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase PFHLONEA_02050 706587.Desti_3511 5.9e-47 193.7 Deltaproteobacteria mscL GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 ko:K03282 ko00000,ko02000 1.A.22.1 Bacteria 1RHG8@1224,2WP7G@28221,42RNC@68525,COG1970@1,COG1970@2 NA|NA|NA M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell PFHLONEA_02051 269799.Gmet_3072 2.6e-58 232.3 Desulfuromonadales ilvA 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 iLJ478.TM0356 Bacteria 1MVWJ@1224,2WM9K@28221,42MKY@68525,43S98@69541,COG1171@1,COG1171@2 NA|NA|NA E PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit PFHLONEA_02052 96561.Dole_1152 7.5e-76 290.4 Desulfobacterales rnfC ko:K03615 ko00000 iHN637.CLJU_RS18525 Bacteria 1MWAX@1224,2MHNS@213118,2WJJB@28221,42NJM@68525,COG4656@1,COG4656@2 NA|NA|NA C Methylene-tetrahydrofolate reductase C terminal PFHLONEA_02053 555088.DealDRAFT_1101 1e-136 494.2 Syntrophomonadaceae pcmB Bacteria 1TQ1A@1239,248EK@186801,42KA9@68298,COG0493@1,COG0493@2 NA|NA|NA C FAD-dependent pyridine nucleotide-disulphide oxidoreductase PFHLONEA_02054 289376.THEYE_A0673 1.6e-65 255.8 Nitrospirae folE GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006082,GO:0006139,GO:0006575,GO:0006725,GO:0006729,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008616,GO:0009058,GO:0009108,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0019752,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0042455,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901657,GO:1901659 2.7.6.3,3.5.4.16 ko:K00950,ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R03503,R04639,R05046,R05048 RC00002,RC00017,RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 iIT341.HP0928,iNJ661.Rv3609c Bacteria 3J0Q0@40117,COG0302@1,COG0302@2 NA|NA|NA F GTP cyclohydrolase I PFHLONEA_02055 926692.AZYG01000049_gene15 6.4e-32 144.1 Halanaerobiales ygfA GO:0003674,GO:0003824,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019752,GO:0022611,GO:0030272,GO:0032502,GO:0034641,GO:0035999,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.2 ko:K01934 ko00670,ko01100,map00670,map01100 R02301 RC00183 ko00000,ko00001,ko01000 iECABU_c1320.ECABU_c31940,iECOK1_1307.ECOK1_3298,iECSF_1327.ECSF_2705,iUTI89_1310.UTI89_C3298 Bacteria 1VA91@1239,24N7H@186801,3WATI@53433,COG0212@1,COG0212@2 NA|NA|NA H PFAM 5-formyltetrahydrofolate cyclo-ligase PFHLONEA_02056 2325.TKV_c20090 2.2e-81 308.9 Thermoanaerobacterales cooC ko:K07321 ko00000 Bacteria 1TPCY@1239,247JM@186801,42F6P@68295,COG3640@1,COG3640@2 NA|NA|NA D CO dehydrogenase PFHLONEA_02057 269799.Gmet_2685 1.9e-96 359.4 Desulfuromonadales rlmN GO:0000049,GO:0000154,GO:0001510,GO:0002935,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016426,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0070040,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:0140102,GO:1901360,GO:1901363 2.1.1.192 ko:K06941 ko00000,ko01000,ko03009 Bacteria 1MUYK@1224,2WIUJ@28221,42N69@68525,43STZ@69541,COG0820@1,COG0820@2 NA|NA|NA J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity PFHLONEA_02058 404380.Gbem_0750 1.4e-41 175.6 Desulfuromonadales cheY40H-4 ko:K03413 ko02020,ko02030,map02020,map02030 M00506 ko00000,ko00001,ko00002,ko02022,ko02035 Bacteria 1MZZV@1224,2WVIG@28221,42UXH@68525,43W0I@69541,COG2199@1,COG3706@2 NA|NA|NA T cheY-homologous receiver domain PFHLONEA_02059 1232410.KI421413_gene806 4.9e-63 248.1 Desulfuromonadales 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 Bacteria 1RJ35@1224,2WPIM@28221,42T0K@68525,43T60@69541,COG2203@1,COG2203@2 NA|NA|NA T Domain present in phytochromes and cGMP-specific phosphodiesterases. PFHLONEA_02060 243231.GSU2214 1.6e-93 349.7 Desulfuromonadales cheB 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 Bacteria 1R5IM@1224,2WMDB@28221,42Q4X@68525,43T38@69541,COG2201@1,COG2201@2 NA|NA|NA NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR PFHLONEA_02061 443143.GM18_3603 9.9e-91 340.1 Desulfuromonadales cheR40H-1 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 ko00000,ko00001,ko01000,ko02035 Bacteria 1MU6W@1224,2WMNM@28221,42QPJ@68525,43UG4@69541,COG1352@1,COG1352@2 NA|NA|NA H Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP PFHLONEA_02062 269799.Gmet_2306 2.5e-20 107.5 Desulfuromonadales Bacteria 1N55Z@1224,2WPWV@28221,42Q7F@68525,43UH8@69541,COG1413@1,COG1413@2 NA|NA|NA C HEAT repeat PFHLONEA_02063 1121456.ATVA01000016_gene2000 3.6e-32 144.8 Desulfovibrionales cheW ko:K03408 ko02020,ko02030,map02020,map02030 ko00000,ko00001,ko02035 Bacteria 1RAH1@1224,2MGVV@213115,2X5TT@28221,42S69@68525,COG0835@1,COG0835@2 NA|NA|NA NT Two component signalling adaptor domain PFHLONEA_02065 1232410.KI421412_gene447 9e-32 146.0 Desulfuromonadales ko:K03406 ko02020,ko02030,map02020,map02030 ko00000,ko00001,ko02035 Bacteria 1RG2B@1224,2WNHC@28221,42RYX@68525,43T4Y@69541,COG0840@1,COG0840@2 NA|NA|NA NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). PFHLONEA_02066 1144275.COCOR_06432 9.6e-39 168.7 Myxococcales rppA ko:K03406 ko02020,ko02030,map02020,map02030 ko00000,ko00001,ko02035 Bacteria 1RG2B@1224,2WNHC@28221,2YU4H@29,42RYX@68525,COG0840@1,COG0840@2,COG2770@1,COG2770@2 NA|NA|NA NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). PFHLONEA_02067 443143.GM18_3087 1.4e-50 206.8 Desulfuromonadales CP_0258 ko:K01989 M00247 ko00000,ko00002,ko02000 Bacteria 1MW5D@1224,2WJW5@28221,42MU0@68525,43UU9@69541,COG2984@1,COG2984@2 NA|NA|NA S ABC transporter substrate binding protein PFHLONEA_02068 269799.Gmet_1745 1.8e-55 224.2 Desulfuromonadales Bacteria 1NTI4@1224,2E1I6@1,2WTNY@28221,32WW2@2,42YDB@68525,43TFS@69541 NA|NA|NA PFHLONEA_02069 316067.Geob_2912 2.1e-84 319.3 Desulfuromonadales omcI Bacteria 1RHMA@1224,2WU8J@28221,42Z4M@68525,43U75@69541,COG3005@1,COG3005@2 NA|NA|NA C cytochrome C PFHLONEA_02070 589865.DaAHT2_0837 1.3e-129 469.2 Desulfobacterales fhs GO:0000096,GO:0000097,GO:0000105,GO:0003674,GO:0003824,GO:0004329,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006144,GO:0006520,GO:0006547,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009108,GO:0009110,GO:0009112,GO:0009113,GO:0009256,GO:0009257,GO:0009396,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0016874,GO:0016879,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0052803,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.5.1.5,3.5.4.9,6.3.4.3 ko:K00288,ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00141,M00377 R00943,R01220,R01655 RC00026,RC00111,RC00202,RC00578 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1MUR8@1224,2MJ0Z@213118,2WJF1@28221,42MKE@68525,COG2759@1,COG2759@2 NA|NA|NA F Belongs to the formate--tetrahydrofolate ligase family PFHLONEA_02071 443144.GM21_2067 1.6e-64 252.3 Bacteria 3.5.4.13 ko:K01494 ko00240,ko01100,map00240,map01100 M00053 R00568,R02325 RC00074 ko00000,ko00001,ko00002,ko01000 Bacteria COG0717@1,COG0717@2 NA|NA|NA F dUTP biosynthetic process PFHLONEA_02072 665571.STHERM_c06110 5.8e-128 464.5 Spirochaetes ko:K09155 ko00000 Bacteria 2J7GM@203691,COG2461@1,COG2461@2 NA|NA|NA S PAS domain PFHLONEA_02073 596151.DesfrDRAFT_1726 7.7e-12 76.6 Desulfovibrionales rbpA Bacteria 1N6VR@1224,2MCID@213115,2WRRT@28221,42V9Q@68525,COG0724@1,COG0724@2 NA|NA|NA S PFAM RNP-1 like RNA-binding protein PFHLONEA_02074 1283300.ATXB01000001_gene146 2.4e-17 95.5 Methylococcales Bacteria 1R5AB@1224,1SJEE@1236,1XGBF@135618,2C5IF@1,2Z9B7@2 NA|NA|NA S Protein of unknown function (DUF1264) PFHLONEA_02078 247490.KSU1_D0644 5.4e-153 547.7 Planctomycetes ko:K02029,ko:K02030 M00236 ko00000,ko00002,ko02000 3.A.1.3 Bacteria 2IY5R@203682,COG0765@1,COG0765@2,COG0834@1,COG0834@2 NA|NA|NA P TIGRFAM amine acid ABC transporter, permease protein, 3-TM region, His Glu Gln Arg opine family PFHLONEA_02080 247490.KSU1_D0643 1.7e-78 299.3 Planctomycetes 3.6.3.21 ko:K02028 M00236 ko00000,ko00002,ko01000,ko02000 3.A.1.3 Bacteria 2IYVK@203682,COG1126@1,COG1126@2 NA|NA|NA E ABC-type polar amino acid transport system ATPase component PFHLONEA_02082 56780.SYN_02155 5.7e-133 481.1 Syntrophobacterales argD GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 iAF987.Gmet_0204,iHN637.CLJU_RS10560 Bacteria 1MV3C@1224,2MQ76@213462,2WIMW@28221,42MHH@68525,COG4992@1,COG4992@2 NA|NA|NA E TIGRFAM acetylornithine and succinylornithine PFHLONEA_02083 635013.TherJR_0353 1.4e-104 386.3 Peptococcaceae argF GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 Bacteria 1TPF2@1239,248I5@186801,2608G@186807,COG0078@1,COG0078@2 NA|NA|NA E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline PFHLONEA_02084 1487921.DP68_16100 1.3e-43 183.3 Clostridiaceae ko:K07010 ko00000,ko01002 Bacteria 1V1KC@1239,24JCU@186801,36DTE@31979,COG2071@1,COG2071@2 NA|NA|NA S Peptidase C26 PFHLONEA_02085 926561.KB900620_gene2911 1.7e-96 360.1 Clostridia ko:K02035,ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 Bacteria 1TNYQ@1239,25E4B@186801,COG4166@1,COG4166@2 NA|NA|NA E Family 5 PFHLONEA_02088 706587.Desti_4751 2.9e-170 605.1 Deltaproteobacteria nuoM GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0048037,GO:0048038,GO:0048039,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1902600,GO:1990204 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 iSDY_1059.SDY_2473 Bacteria 1MV7V@1224,2X5HD@28221,42MBQ@68525,COG1008@1,COG1008@2 NA|NA|NA C NADH-quinone oxidoreductase, chain M PFHLONEA_02089 1123368.AUIS01000006_gene665 8.2e-53 213.8 Acidithiobacillales nuoL GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015672,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0051179,GO:0051234,GO:0055085,GO:0070469,GO:0070470,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1902600,GO:1990204 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 e_coli_core.b2278,iAF1260.b2278,iBWG_1329.BWG_2052,iECDH10B_1368.ECDH10B_2440,iECDH1ME8569_1439.ECDH1ME8569_2215,iEcDH1_1363.EcDH1_1379,iJN746.PP_4129,iJO1366.b2278,iJR904.b2278,iY75_1357.Y75_RS11945 Bacteria 1MW2M@1224,1RNKN@1236,2NCNU@225057,COG1009@1,COG1009@2 NA|NA|NA CP NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus PFHLONEA_02090 443143.GM18_3171 7.1e-87 327.4 Deltaproteobacteria Bacteria 1MX4H@1224,2WJ2Y@28221,42PY0@68525,COG0491@1,COG0491@2 NA|NA|NA S Metallo-beta-lactamase superfamily PFHLONEA_02093 909663.KI867150_gene485 2.5e-73 282.7 Syntrophobacterales hdrA 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 Bacteria 1N26U@1224,2MRJK@213462,2X2B6@28221,43EWE@68525,COG1148@1,COG1148@2 NA|NA|NA C 4Fe-4S binding domain PFHLONEA_02095 335543.Sfum_0670 3.6e-29 134.4 Syntrophobacterales ko:K13735 ko05100,map05100 ko00000,ko00001 Bacteria 1PFB5@1224,2MRPS@213462,2X2NT@28221,437G8@68525,COG4447@1,COG4447@2 NA|NA|NA S cellulose binding PFHLONEA_02097 1232410.KI421415_gene3017 5e-176 624.4 Desulfuromonadales hflX ko:K03665 ko00000,ko03009 Bacteria 1MUA0@1224,2WIMU@28221,42NA6@68525,43SCK@69541,COG2262@1,COG2262@2 NA|NA|NA S GTP-binding GTPase Middle Region PFHLONEA_02098 1047013.AQSP01000111_gene1661 6.9e-13 80.9 unclassified Bacteria yegQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 ko:K08303 ko05120,map05120 ko00000,ko00001,ko01000,ko01002 Bacteria 2NS1M@2323,COG0826@1,COG0826@2 NA|NA|NA O peptidase U32 PFHLONEA_02104 1125863.JAFN01000001_gene2024 1.1e-12 80.1 Deltaproteobacteria gspM ko:K02462 ko03070,ko05111,map03070,map05111 M00331 ko00000,ko00001,ko00002,ko02044 3.A.15 Bacteria 1NEZ3@1224,2WSE1@28221,42WMP@68525,COG3149@1,COG3149@2 NA|NA|NA U Type II secretion system (T2SS), protein M PFHLONEA_02105 1121405.dsmv_0462 8.3e-28 131.7 Desulfobacterales gspL ko:K02461,ko:K02662 ko03070,ko05111,map03070,map05111 M00331 ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15 Bacteria 1MYIB@1224,2MKAU@213118,2WP1G@28221,42SIX@68525,COG4972@1,COG4972@2 NA|NA|NA NU Fimbrial assembly family protein PFHLONEA_02106 316067.Geob_0889 7.3e-09 68.2 Deltaproteobacteria gspK GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 ko:K02460,ko:K12286 ko03070,ko05111,map03070,map05111 M00331 ko00000,ko00001,ko00002,ko02044 3.A.15 Bacteria 1N9I4@1224,2WRR8@28221,42V0N@68525,COG3156@1,COG3156@2 NA|NA|NA U PFAM General secretion pathway protein K PFHLONEA_02107 391625.PPSIR1_25836 6.1e-09 68.2 Myxococcales gspJ GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0098776 ko:K02459 ko03070,ko05111,map03070,map05111 M00331 ko00000,ko00001,ko00002,ko02044 3.A.15 Bacteria 1NPEC@1224,2WSPB@28221,2YVMW@29,42WZG@68525,COG4795@1,COG4795@2 NA|NA|NA U Type II secretion system (T2SS), protein J PFHLONEA_02108 1232410.KI421418_gene2153 1.4e-08 66.2 Desulfuromonadales gspI ko:K02458 ko03070,ko05111,map03070,map05111 M00331 ko00000,ko00001,ko00002,ko02044 3.A.15 Bacteria 1PSVT@1224,2X2IT@28221,43EXX@68525,43VM1@69541,COG4967@1,COG4967@2 NA|NA|NA NU Prokaryotic N-terminal methylation motif PFHLONEA_02109 1232410.KI421418_gene2154 1.8e-16 92.8 Desulfuromonadales gspI ko:K02457,ko:K02458,ko:K10926 ko03070,ko05111,map03070,map05111 M00331 ko00000,ko00001,ko00002,ko02044 3.A.15 Bacteria 1NZKC@1224,2WVSQ@28221,430RG@68525,43V4M@69541,COG2165@1,COG2165@2 NA|NA|NA NU general secretion pathway protein PFHLONEA_02110 1125863.JAFN01000001_gene2967 6.6e-46 190.3 Deltaproteobacteria gspG ko:K02246,ko:K02456 ko03070,ko05111,map03070,map05111 M00331,M00429 ko00000,ko00001,ko00002,ko02044 3.A.15 Bacteria 1RDX2@1224,2WP3B@28221,42SFB@68525,COG2165@1,COG2165@2 NA|NA|NA U general secretion pathway protein G PFHLONEA_02111 404589.Anae109_0728 6.5e-96 357.8 Myxococcales gspF GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0016020,GO:0032940,GO:0033036,GO:0042886,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098776 ko:K02455,ko:K02653 ko03070,ko05111,map03070,map05111 M00331 ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 Bacteria 1MV4U@1224,2WJE0@28221,2YTZT@29,42MH9@68525,COG1459@1,COG1459@2 NA|NA|NA U General secretion pathway protein F PFHLONEA_02112 215803.DB30_5334 7.2e-170 604.0 Myxococcales gspE ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 Bacteria 1MU7V@1224,2WIPP@28221,2YUKY@29,42M51@68525,COG2804@1,COG2804@2 NA|NA|NA NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB PFHLONEA_02113 96561.Dole_3193 4.3e-79 301.6 Desulfobacterales 2.7.11.1,2.7.13.3,3.1.3.3 ko:K03407,ko:K07315,ko:K12132 ko02020,ko02030,map02020,map02030 M00506 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035,ko03021 Bacteria 1NT1K@1224,2MMVQ@213118,2WN0S@28221,42R1P@68525,COG2199@1,COG2199@2,COG3850@1,COG3850@2 NA|NA|NA T PFAM GGDEF domain containing protein PFHLONEA_02117 56780.SYN_00856 4.3e-123 448.0 Deltaproteobacteria ko:K00786 ko00000,ko01000 Bacteria 1MXG7@1224,2X5MW@28221,42MRD@68525,COG1215@1,COG1215@2 NA|NA|NA M Glycosyl transferase family 21 PFHLONEA_02118 1049564.TevJSym_ap00330 4.4e-28 131.0 Gammaproteobacteria 2.7.7.72 ko:K00974 ko03013,map03013 R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 Bacteria 1RJU0@1224,1S8F6@1236,COG1371@1,COG1371@2 NA|NA|NA S Archease protein family (MTH1598/TM1083) PFHLONEA_02120 373903.Hore_00620 1.3e-88 333.2 Halanaerobiales nadA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0030312,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS12020 Bacteria 1TP6R@1239,247IJ@186801,3WA9Y@53433,COG0379@1,COG0379@2 NA|NA|NA H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate PFHLONEA_02121 1047013.AQSP01000140_gene2513 1.6e-85 323.2 unclassified Bacteria rmuC ko:K09760 ko00000 Bacteria 2NPXU@2323,COG1322@1,COG1322@2 NA|NA|NA S RmuC family PFHLONEA_02125 247490.KSU1_B0448 2.9e-67 261.5 Bacteria flr Bacteria COG1853@1,COG1853@2 NA|NA|NA S FMN binding PFHLONEA_02128 56780.SYN_02111 4e-40 171.0 Deltaproteobacteria Bacteria 1NA6E@1224,2ED7H@1,2WS45@28221,33743@2,42V2U@68525 NA|NA|NA PFHLONEA_02130 1111479.AXAR01000004_gene2204 5.8e-178 630.9 Bacilli kscP ko:K08677 ko00000,ko01002 Bacteria 1VSEJ@1239,4HU7V@91061,COG4934@1,COG4934@2 NA|NA|NA O Pro-kumamolisin, activation domain PFHLONEA_02131 933262.AXAM01000009_gene1466 1.7e-33 149.8 Desulfobacterales wecA GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0005975,GO:0005976,GO:0006629,GO:0008144,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008963,GO:0009058,GO:0009059,GO:0009103,GO:0009246,GO:0009274,GO:0009276,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016051,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0030312,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0033692,GO:0034637,GO:0034645,GO:0042546,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046378,GO:0046872,GO:0046914,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.8.33,2.7.8.35,5.1.3.14 ko:K01791,ko:K02851 ko00520,ko01100,ko05111,map00520,map01100,map05111 M00362 R00420,R08856 RC00002,RC00290 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 iAF987.Gmet_1505,iECSF_1327.ECSF_3624 Bacteria 1MWYW@1224,2MJRY@213118,2WK13@28221,42QFA@68525,COG0472@1,COG0472@2 NA|NA|NA M Glycosyl transferase family 4 PFHLONEA_02132 56780.SYN_01095 1.1e-41 178.3 Deltaproteobacteria Bacteria 1MXMD@1224,2WIY5@28221,42NZK@68525,COG0457@1,COG0457@2 NA|NA|NA A Tetratricopeptide TPR_2 repeat protein PFHLONEA_02133 933262.AXAM01000009_gene1468 1.4e-49 203.0 Desulfobacterales ko:K01991,ko:K02237 ko02026,map02026 M00429 ko00000,ko00001,ko00002,ko02000,ko02044 1.B.18,3.A.11.1,3.A.11.2 Bacteria 1N7GP@1224,2MKDY@213118,2WNYF@28221,42SP0@68525,COG1596@1,COG1596@2 NA|NA|NA M Polysaccharide biosynthesis/export protein PFHLONEA_02134 933262.AXAM01000009_gene1469 5e-40 172.2 Desulfobacterales ko:K20920 ko05111,map05111 ko00000,ko00001,ko02000 1.B.66.3.1,1.B.66.3.2 Bacteria 1N5KN@1224,2MMEY@213118,2WQAA@28221,42UYK@68525,COG5338@1,COG5338@2 NA|NA|NA S Protein conserved in bacteria PFHLONEA_02136 330214.NIDE1608 1e-23 117.1 Bacteria 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 ko00000,ko00001,ko00002,ko01000,ko04147 CBM48,GH13 Bacteria COG0296@1,COG0296@2 NA|NA|NA G 1,4-alpha-glucan branching enzyme activity PFHLONEA_02137 316274.Haur_3433 1.5e-31 142.9 Chloroflexia ko:K03088 ko00000,ko03021 Bacteria 2G6T5@200795,375JF@32061,COG1595@1,COG1595@2 NA|NA|NA K PFAM sigma-70 region 2 domain protein PFHLONEA_02138 941824.TCEL_01381 8.1e-15 86.7 Clostridiaceae apu 3.2.1.133,3.2.1.135,3.2.1.54 ko:K01208 ko00500,ko01100,map00500,map01100 R02112,R03122,R11262 ko00000,ko00001,ko01000 GH13 Bacteria 1TNZ0@1239,247YM@186801,36EQD@31979,COG0296@1,COG0296@2,COG0366@1,COG0366@2 NA|NA|NA G Belongs to the glycosyl hydrolase 13 family PFHLONEA_02140 1322246.BN4_12518 4.8e-66 258.5 Desulfovibrionales mreB GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005856,GO:0005886,GO:0007049,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0032505,GO:0042802,GO:0043093,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051301,GO:0051302,GO:0051782,GO:0051983,GO:0065007,GO:0065008,GO:0071944 ko:K03569 ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 Bacteria 1MUMW@1224,2M7RW@213115,2WIQR@28221,42M1J@68525,COG1077@1,COG1077@2 NA|NA|NA D Cell shape determining protein MreB Mrl PFHLONEA_02141 1209989.TepiRe1_2036 1.4e-39 169.5 Thermoanaerobacterales ETR1 Bacteria 1V6MN@1239,24JDQ@186801,42GGE@68295,COG4191@1,COG4191@2 NA|NA|NA H PFAM ATP-binding region, ATPase domain protein PFHLONEA_02142 706587.Desti_2749 5.1e-42 177.9 Deltaproteobacteria 3.1.3.97 ko:K07053 R00188,R11188 RC00078 ko00000,ko01000 Bacteria 1N68X@1224,2WR34@28221,42TYN@68525,COG0613@1,COG0613@2 NA|NA|NA S PHP-associated PFHLONEA_02143 706587.Desti_2748 5.3e-27 127.1 Bacteria Bacteria COG4109@1,COG4109@2 NA|NA|NA K DRTGG domain PFHLONEA_02144 706587.Desti_2743 1.8e-56 226.5 Bacteria RsbW 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 Bacteria COG2172@1,COG2172@2,COG2524@1,COG2524@2 NA|NA|NA K Domain in cystathionine beta-synthase and other proteins. PFHLONEA_02145 1123288.SOV_1c07880 3.1e-22 111.3 Negativicutes Bacteria 1VA3T@1239,4H5DJ@909932,COG4109@1,COG4109@2 NA|NA|NA K DRTGG domain protein PFHLONEA_02146 1162668.LFE_1697 2e-35 155.2 Nitrospirae nuoD GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00333,ko:K13378 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 3J0FM@40117,COG0649@1,COG0649@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient PFHLONEA_02147 1123376.AUIU01000001_gene776 7.4e-08 63.9 Bacteria Bacteria COG0589@1,COG0589@2 NA|NA|NA T AMP binding PFHLONEA_02148 1128427.KB904821_gene4001 1.1e-91 344.0 Oscillatoriales 5.4.99.9 ko:K01854 ko00052,ko00520,map00052,map00520 R00505,R09009 RC00317,RC02396 ko00000,ko00001,ko01000 Bacteria 1G05M@1117,1H8M6@1150,COG1232@1,COG1232@2 NA|NA|NA H Protoporphyrinogen oxidase PFHLONEA_02150 716928.AJQT01000047_gene2149 1.2e-154 553.1 Alphaproteobacteria ko:K02027 M00207 ko00000,ko00002,ko02000 3.A.1.1 Bacteria 1MU64@1224,2VFE8@28211,COG1653@1,COG1653@2 NA|NA|NA G Extracellular solute-binding protein PFHLONEA_02151 589924.Ferp_1746 4.1e-45 187.6 Euryarchaeota hemE 2.1.1.246,2.1.1.247,4.1.1.37 ko:K01599,ko:K14080,ko:K14082 ko00680,ko00860,ko01100,ko01110,ko01120,ko01200,map00680,map00860,map01100,map01110,map01120,map01200 M00121,M00356,M00563 R03197,R04972,R09098,R09124,R09998,R09999,R10000 RC00035,RC00556,RC00732,RC00872,RC01144,RC02440,RC02984,RC02985,RC02986 ko00000,ko00001,ko00002,ko01000 Archaea 2XV21@28890,COG0407@1,arCOG03323@2157 NA|NA|NA H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III PFHLONEA_02152 635013.TherJR_0983 9.8e-81 306.6 Peptococcaceae Bacteria 1V1P0@1239,24G08@186801,2626Y@186807,COG5012@1,COG5012@2 NA|NA|NA S Methionine synthase, cobalamin (vitamin B12)-binding module, cap PFHLONEA_02153 1121430.JMLG01000004_gene809 2.7e-40 172.2 Peptococcaceae Bacteria 1TP6Q@1239,24B04@186801,2670T@186807,COG1600@1,COG1600@2 NA|NA|NA C TIGRFAM iron-sulfur cluster binding protein PFHLONEA_02155 1232410.KI421428_gene968 3e-110 405.2 Deltaproteobacteria Bacteria 1R58E@1224,2WPAQ@28221,42NSA@68525,COG0535@1,COG0535@2 NA|NA|NA C Iron-sulfur cluster-binding domain PFHLONEA_02156 264732.Moth_1212 1.1e-60 239.6 Thermoanaerobacterales Bacteria 1V4DP@1239,24HBZ@186801,42J1R@68295,COG0778@1,COG0778@2 NA|NA|NA C Nitroreductase family PFHLONEA_02158 706587.Desti_2024 8.8e-140 504.2 Syntrophobacterales 2.7.13.3 ko:K02030,ko:K13040 ko02020,map02020 M00236,M00514 ko00000,ko00001,ko00002,ko01000,ko01001,ko02000,ko02022 3.A.1.3 Bacteria 1RCM9@1224,2MQW1@213462,2WJT4@28221,42N46@68525,COG0784@1,COG0784@2,COG0834@1,COG0834@2,COG2202@1,COG2202@2,COG4191@1,COG4191@2 NA|NA|NA T His Kinase A (phosphoacceptor) domain PFHLONEA_02159 443254.Marpi_0217 5.4e-38 163.7 Thermotogae Bacteria 2GDP0@200918,COG4912@1,COG4912@2 NA|NA|NA L PFAM DNA alkylation repair enzyme PFHLONEA_02160 316067.Geob_1750 4.1e-46 191.0 Desulfuromonadales folA 1.5.1.3 ko:K00287,ko:K18589,ko:K18590 ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523 M00126,M00840 R00936,R00937,R00939,R00940,R02235,R02236,R11765 RC00109,RC00110,RC00158 br01600,ko00000,ko00001,ko00002,ko01000,ko01504 Bacteria 1RH0P@1224,2WQAV@28221,42UMS@68525,43SQB@69541,COG0262@1,COG0262@2 NA|NA|NA H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis PFHLONEA_02162 671143.DAMO_1565 4e-139 501.1 unclassified Bacteria ftsH GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019222,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 ko:K03798 M00742 ko00000,ko00002,ko01000,ko01002,ko03110 Bacteria 2NNQ5@2323,COG0465@1,COG0465@2 NA|NA|NA O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins PFHLONEA_02163 246194.CHY_2383 6.1e-88 331.3 Thermoanaerobacterales folP GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.15,2.7.6.3 ko:K00796,ko:K13941 ko00790,ko01100,map00790,map01100 M00126,M00840,M00841 R03066,R03067,R03503 RC00002,RC00017,RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS03115 Bacteria 1TPKT@1239,248BE@186801,42FAT@68295,COG0294@1,COG0294@2 NA|NA|NA H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives PFHLONEA_02164 1123376.AUIU01000011_gene928 2.5e-75 288.9 Nitrospirae dacA 2.7.7.85 ko:K18672 ko00000,ko01000 Bacteria 3J0XP@40117,COG1624@1,COG1624@2 NA|NA|NA S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria PFHLONEA_02165 289376.THEYE_A0045 7.4e-30 137.5 Nitrospirae dacA Bacteria 3J1EE@40117,COG4856@1,COG4856@2 NA|NA|NA S YbbR-like protein PFHLONEA_02167 1232410.KI421424_gene1758 4.7e-134 484.6 Deltaproteobacteria ko:K00185 ko00000 5.A.3 Bacteria 1PFX4@1224,2WJHN@28221,42NUN@68525,COG5557@1,COG5557@2 NA|NA|NA C PFAM Polysulphide reductase, NrfD PFHLONEA_02168 1121920.AUAU01000009_gene1859 6.5e-101 373.6 Acidobacteria ko:K00184 ko00000 5.A.3 Bacteria 3Y2Z0@57723,COG0437@1,COG0437@2 NA|NA|NA C 4Fe-4S dicluster domain PFHLONEA_02169 1232410.KI421415_gene3122 6.2e-39 167.5 Desulfuromonadales ko:K03688 ko00000 Bacteria 1MU1Z@1224,2WK1B@28221,42N87@68525,43S4A@69541,COG0661@1,COG0661@2 NA|NA|NA S ABC1 family PFHLONEA_02170 289376.THEYE_A0365 2e-74 286.2 Nitrospirae mltG ko:K07082 ko00000 Bacteria 3J0IR@40117,COG1559@1,COG1559@2 NA|NA|NA S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation PFHLONEA_02172 395961.Cyan7425_4809 2.2e-16 91.7 Cyanothece Bacteria 1G5BB@1117,3KGBC@43988,COG2199@1,COG3706@2 NA|NA|NA T PFAM GGDEF domain containing protein PFHLONEA_02173 397948.Cmaq_0518 3.8e-50 204.9 Archaea Archaea COG1028@1,arCOG01261@2157 NA|NA|NA IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) PFHLONEA_02174 1499967.BAYZ01000145_gene6206 5.3e-30 137.1 unclassified Bacteria folX GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008719,GO:0009987,GO:0016853,GO:0019752,GO:0034641,GO:0042558,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0071704,GO:1901360,GO:1901564 1.13.11.81,4.1.2.25,5.1.99.7,5.1.99.8 ko:K01633,ko:K07589 ko00790,ko01100,map00790,map01100 M00126,M00840 R03504,R11037,R11073,R11082 RC00721,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 Bacteria 2NQ1A@2323,COG1539@1,COG1539@2 NA|NA|NA H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin PFHLONEA_02175 397948.Cmaq_0517 1.9e-36 159.1 Archaea Archaea COG0801@1,arCOG07203@2157 NA|NA|NA H Dihydroneopterin aldolase PFHLONEA_02176 1499967.BAYZ01000145_gene6204 1.9e-61 242.3 unclassified Bacteria folE GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 Bacteria 2NPAT@2323,COG0302@1,COG0302@2 NA|NA|NA H GTP cyclohydrolase I PFHLONEA_02178 316067.Geob_0760 2.3e-49 202.2 Bacteria Bacteria 28HPC@1,2Z7XD@2 NA|NA|NA S Domain of unknown function (DUF4337) PFHLONEA_02179 386456.JQKN01000008_gene1461 7e-61 240.7 Methanobacteria Archaea 23PM9@183925,2XXAZ@28890,arCOG03165@1,arCOG03165@2157 NA|NA|NA PFHLONEA_02180 443143.GM18_2580 2.7e-33 149.8 Desulfuromonadales Bacteria 1MUBV@1224,2WQR1@28221,42TT7@68525,43TI3@69541,COG1652@1,COG1652@2 NA|NA|NA S LysM domain PFHLONEA_02181 1232410.KI421415_gene3124 1.4e-136 493.8 Desulfuromonadales ntrY GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.13.3 ko:K13598 ko02020,map02020 M00498 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 1MWKZ@1224,2WIYA@28221,42MCN@68525,43SDF@69541,COG5000@1,COG5000@2 NA|NA|NA T PAS domain PFHLONEA_02182 888062.HMPREF9083_0451 4.5e-16 90.9 Negativicutes Bacteria 1U0PW@1239,4H5KG@909932,COG0607@1,COG0607@2 NA|NA|NA P Rhodanese Homology Domain PFHLONEA_02183 573063.Metin_0339 2.1e-32 146.0 Euryarchaeota ogg 4.2.99.18 ko:K03653 ko00000,ko01000 Archaea 2XWSZ@28890,COG1059@1,arCOG04357@2157 NA|NA|NA L Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites) PFHLONEA_02184 1232410.KI421424_gene1749 3.1e-47 196.1 Desulfuromonadales 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 Bacteria 1QW3K@1224,2X7EV@28221,43C4E@68525,43S1I@69541,COG0412@1,COG0412@2 NA|NA|NA Q Dienelactone hydrolase PFHLONEA_02188 443143.GM18_3144 1.8e-92 345.5 Deltaproteobacteria Bacteria 1R5UU@1224,2WPK7@28221,42SE7@68525,COG0262@1,COG0262@2 NA|NA|NA H PFAM bifunctional deaminase-reductase domain protein PFHLONEA_02190 717605.Theco_0795 2.4e-21 109.0 Paenibacillaceae mchD Bacteria 1VW9Q@1239,26YQB@186822,4HWSC@91061,COG5528@1,COG5528@2 NA|NA|NA S Predicted integral membrane protein (DUF2269) PFHLONEA_02191 1158338.JNLJ01000001_gene951 4.3e-18 98.6 Bacteria Bacteria COG3005@1,COG3005@2 NA|NA|NA C denitrification pathway PFHLONEA_02192 398767.Glov_2659 2e-73 282.7 Deltaproteobacteria copC ko:K07245,ko:K14166 ko00000,ko02000 9.B.62.1 Bacteria 1N3DP@1224,2WQFI@28221,42U1X@68525,COG1276@1,COG1276@2,COG4892@1,COG4892@2 NA|NA|NA P PFAM Cytochrome b5 PFHLONEA_02193 608538.HTH_1240 7.7e-09 66.6 Bacteria Bacteria COG1917@1,COG1917@2 NA|NA|NA L Cupin 2, conserved barrel domain protein PFHLONEA_02195 264462.Bd2601 6.8e-34 151.0 delta/epsilon subdivisions norC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K02305 ko00910,ko01120,map00910,map01120 M00529 R00294 RC02794 ko00000,ko00001,ko00002 3.D.4.10 Bacteria 1RDSI@1224,42WEW@68525,COG2010@1,COG2010@2 NA|NA|NA C cytochrome c PFHLONEA_02197 1122919.KB905549_gene1978 5.4e-20 103.2 Paenibacillaceae rph GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006401,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043170,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:1901361,GO:1901575 2.7.7.56,3.6.1.66 ko:K00989,ko:K02428 ko00230,map00230 R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000,ko03016 Bacteria 1TQM3@1239,26RZT@186822,4HBH3@91061,COG0689@1,COG0689@2 NA|NA|NA J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates PFHLONEA_02198 401526.TcarDRAFT_1759 6.7e-75 287.0 Negativicutes Bacteria 1UFX2@1239,4H3Y3@909932,COG2119@1,COG2119@2 NA|NA|NA S Uncharacterized protein family UPF0016 PFHLONEA_02199 1262914.BN533_01797 1.8e-09 68.6 Bacteria Bacteria COG0607@1,COG0607@2 NA|NA|NA P Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS PFHLONEA_02201 96561.Dole_2209 7.4e-34 150.6 Desulfobacterales pal ko:K03640 ko00000,ko02000 2.C.1.2 Bacteria 1MZTV@1224,2MJUT@213118,2WNZS@28221,42R5H@68525,COG2885@1,COG2885@2 NA|NA|NA M Belongs to the ompA family PFHLONEA_02202 1232410.KI421425_gene1543 4.7e-127 461.5 Desulfuromonadales Bacteria 1R65W@1224,2WT3A@28221,42XJ0@68525,43SUP@69541,COG0810@1,COG0810@2 NA|NA|NA M Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins PFHLONEA_02203 443144.GM21_0444 3.4e-43 181.4 Desulfuromonadales aglS ko:K03559 ko00000,ko02000 1.A.30.2.1 Bacteria 1RENY@1224,2WT0T@28221,42X3K@68525,43V5B@69541,COG0848@1,COG0848@2 NA|NA|NA U Biopolymer transport protein ExbD/TolR PFHLONEA_02204 404380.Gbem_0506 1.1e-94 353.2 Desulfuromonadales 1.1.1.1,1.6.5.5 ko:K00001,ko:K00344 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 Bacteria 1MX8A@1224,2WM4P@28221,42QBD@68525,43T7G@69541,COG0604@1,COG0604@2 NA|NA|NA C Zinc-binding dehydrogenase PFHLONEA_02205 456442.Mboo_1138 3.4e-93 348.2 Methanomicrobia ko:K15777 ko00965,map00965 R08836 RC00387 ko00000,ko00001,ko01000 Archaea 2NAWC@224756,2Y0BA@28890,COG3384@1,arCOG01730@2157 NA|NA|NA E Catalytic LigB subunit of aromatic ring-opening dioxygenase PFHLONEA_02206 472759.Nhal_1302 0.0 1202.6 Chromatiales pepN GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0009056,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0033218,GO:0034641,GO:0042277,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 iECIAI1_1343.ECIAI1_0973,iECO103_1326.ECO103_0977,iECP_1309.ECP_0944,iECSE_1348.ECSE_0993,iECW_1372.ECW_m1042,iEKO11_1354.EKO11_2898,iWFL_1372.ECW_m1042 Bacteria 1MUCI@1224,1RMA7@1236,1WWVT@135613,COG0308@1,COG0308@2 NA|NA|NA E PFAM peptidase M1, membrane alanine aminopeptidase PFHLONEA_02207 1267535.KB906767_gene1056 1.5e-124 452.6 Acidobacteriia mocA 1.1.1.91 ko:K05882 ko00000,ko01000 Bacteria 2JIS2@204432,3Y311@57723,COG0667@1,COG0667@2 NA|NA|NA C Aldo/keto reductase family PFHLONEA_02208 1499967.BAYZ01000154_gene1500 2.8e-240 838.2 unclassified Bacteria ileS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 iG2583_1286.G2583_0027,iPC815.YPO0475 Bacteria 2NNT5@2323,COG0060@1,COG0060@2 NA|NA|NA J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) PFHLONEA_02209 768670.Calni_0644 1.4e-13 82.4 Bacteria Bacteria 2DRRJ@1,33CRQ@2 NA|NA|NA S Cytochrome c7 and related cytochrome c PFHLONEA_02210 635013.TherJR_2777 1.2e-20 105.1 Peptococcaceae cspB ko:K03704 ko00000,ko03000 Bacteria 1VEE0@1239,24QJE@186801,262QJ@186807,COG1278@1,COG1278@2 NA|NA|NA K PFAM Cold-shock PFHLONEA_02212 768670.Calni_0644 1.2e-17 95.9 Bacteria Bacteria 2DRRJ@1,33CRQ@2 NA|NA|NA S Cytochrome c7 and related cytochrome c PFHLONEA_02214 644282.Deba_2665 6e-09 67.4 Deltaproteobacteria Bacteria 1NN3C@1224,2ENBB@1,2WTC3@28221,32JZD@2,42XM1@68525 NA|NA|NA PFHLONEA_02215 935948.KE386495_gene1368 2.3e-78 298.9 Thermoanaerobacterales mazG 3.6.1.66,3.6.1.9 ko:K02428,ko:K02499,ko:K04765 ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100 R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R01855,R02100,R02720,R03004,R03036,R03531,R11323 RC00002 ko00000,ko00001,ko01000,ko03036 iJN678.sll1005 Bacteria 1TPK1@1239,247XM@186801,42FE4@68295,COG1694@1,COG3956@2 NA|NA|NA S TIGRFAM MazG family protein PFHLONEA_02216 1304888.ATWF01000001_gene876 2.1e-12 79.7 Bacteria ligA1 Bacteria COG5492@1,COG5492@2 NA|NA|NA N domain, Protein PFHLONEA_02217 696369.KI912183_gene2604 5.3e-79 301.2 Peptococcaceae 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1TP1W@1239,249R3@186801,264VH@186807,COG1249@1,COG1249@2 NA|NA|NA C pyridine nucleotide-disulphide oxidoreductase dimerisation PFHLONEA_02218 204669.Acid345_4349 1.7e-21 109.4 Acidobacteriia ko:K03611 ko00000,ko03110 5.A.2.1 Bacteria 2JJFH@204432,3Y4X7@57723,COG2010@1,COG2010@2 NA|NA|NA C Cytochrome C oxidase, cbb3-type, subunit III PFHLONEA_02219 1123376.AUIU01000014_gene606 8.2e-184 650.2 Nitrospirae serA 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 3J0DZ@40117,COG0111@1,COG0111@2 NA|NA|NA E Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family PFHLONEA_02220 1123376.AUIU01000014_gene605 6.8e-156 557.0 Nitrospirae GO:0001505,GO:0003674,GO:0003824,GO:0004760,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006807,GO:0008150,GO:0008152,GO:0008453,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019265,GO:0019752,GO:0042133,GO:0042136,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 Bacteria 3J0FC@40117,COG0075@1,COG0075@2 NA|NA|NA E Evidence 2b Function of strongly homologous gene PFHLONEA_02222 1304284.L21TH_1836 7.1e-23 114.4 Clostridiaceae gspE ko:K02652 ko00000,ko02035,ko02044 3.A.15.2 Bacteria 1TPGE@1239,247KA@186801,36DG2@31979,COG2804@1,COG2804@2 NA|NA|NA NU type II secretion system protein E PFHLONEA_02223 1042375.AFPL01000004_gene605 9.3e-21 105.9 Gammaproteobacteria Bacteria 1RE1Q@1224,1S4I9@1236,29FS0@1,302PP@2 NA|NA|NA PFHLONEA_02224 933262.AXAM01000024_gene742 1.9e-66 259.2 Desulfobacterales Bacteria 1RA5I@1224,2C8XG@1,2MJGK@213118,2WMYW@28221,2Z7PK@2,42QRD@68525 NA|NA|NA S Protein of unknown function (DUF4197) PFHLONEA_02225 247490.KSU1_D0148 4.4e-96 358.2 Planctomycetes yagE Bacteria 2J0AJ@203682,COG1723@1,COG1723@2 NA|NA|NA S PFAM Uncharacterised ACR, YagE family COG1723 PFHLONEA_02226 123214.PERMA_0513 8.1e-78 297.7 Aquificae Bacteria 2G4HS@200783,COG2204@1,COG2204@2 NA|NA|NA K Sigma-54 interaction domain PFHLONEA_02227 1163617.SCD_n00425 6.5e-39 167.2 Betaproteobacteria 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 1RHRM@1224,2VTBD@28216,COG0662@1,COG0662@2 NA|NA|NA G Cupin 2, conserved barrel domain protein PFHLONEA_02229 323261.Noc_1117 1.6e-202 712.6 Chromatiales nuoL GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015672,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0051179,GO:0051234,GO:0055085,GO:0070469,GO:0070470,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1902600,GO:1990204 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 e_coli_core.b2278,iAF1260.b2278,iBWG_1329.BWG_2052,iECDH10B_1368.ECDH10B_2440,iECDH1ME8569_1439.ECDH1ME8569_2215,iEcDH1_1363.EcDH1_1379,iJN746.PP_4129,iJO1366.b2278,iJR904.b2278,iY75_1357.Y75_RS11945 Bacteria 1MW2M@1224,1RNKN@1236,1WWQ6@135613,COG1009@1,COG1009@2 NA|NA|NA CP NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein PFHLONEA_02230 485916.Dtox_4297 6.4e-53 213.8 Firmicutes 2.3.1.79 ko:K00661 ko00000,ko01000 Bacteria 1VW2R@1239,COG0454@1,COG0456@2 NA|NA|NA K Acetyltransferase (GNAT) domain PFHLONEA_02231 306281.AJLK01000008_gene5848 1.2e-83 317.0 Cyanobacteria mdsC 2.7.1.162,2.7.1.39 ko:K02204,ko:K13059 ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 M00018 R01771,R08962 RC00002,RC00017,RC00078 ko00000,ko00001,ko00002,ko01000 Bacteria 1G1QD@1117,COG2334@1,COG2334@2 NA|NA|NA S PFAM Phosphotransferase enzyme family PFHLONEA_02232 351160.LRC529 7.6e-56 223.8 Methanomicrobia Archaea 2NB4B@224756,2Y71Z@28890,COG0500@1,arCOG02702@2157 NA|NA|NA Q Methyltransferase domain PFHLONEA_02234 269799.Gmet_2030 3.2e-57 228.8 Desulfuromonadales wza ko:K01991 ko02026,map02026 ko00000,ko00001,ko02000 1.B.18 Bacteria 1RD6G@1224,2WNG9@28221,42RRZ@68525,43TX1@69541,COG1596@1,COG1596@2 NA|NA|NA M Polysaccharide biosynthesis/export protein PFHLONEA_02235 269799.Gmet_2031 5.5e-144 517.7 Desulfuromonadales tuaA Bacteria 1MV6W@1224,2WJMA@28221,42NH8@68525,43S24@69541,COG2148@1,COG2148@2 NA|NA|NA M Bacterial sugar transferase PFHLONEA_02237 395961.Cyan7425_4809 4.2e-09 67.0 Cyanothece Bacteria 1G5BB@1117,3KGBC@43988,COG2199@1,COG3706@2 NA|NA|NA T PFAM GGDEF domain containing protein PFHLONEA_02239 1125863.JAFN01000001_gene869 3.8e-41 175.3 Deltaproteobacteria 5.3.4.1 ko:K03981 ko00000,ko01000,ko02044,ko03110 3.A.7.11.1 Bacteria 1RD39@1224,2WMZS@28221,42QRZ@68525,COG1651@1,COG1651@2 NA|NA|NA M Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process PFHLONEA_02240 1082933.MEA186_02043 2.8e-35 154.8 Alphaproteobacteria Bacteria 1NH3X@1224,2VGUW@28211,COG4319@1,COG4319@2 NA|NA|NA S SnoaL-like domain PFHLONEA_02241 1120963.KB894497_gene2189 5.3e-43 180.6 Gammaproteobacteria ko:K21572 ko00000,ko02000 8.A.46.1,8.A.46.3 Bacteria 1N2JT@1224,1S9TE@1236,COG2913@1,COG2913@2 NA|NA|NA J Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane PFHLONEA_02242 290317.Cpha266_0021 2.7e-30 138.7 Bacteria Bacteria 2ATAH@1,31ITJ@2 NA|NA|NA PFHLONEA_02243 1268622.AVS7_02516 1.5e-47 195.7 Betaproteobacteria Bacteria 1RHZY@1224,2B047@1,2W3AW@28216,31SEM@2 NA|NA|NA PFHLONEA_02244 1244528.CFT03427_0207 2.9e-19 102.8 Epsilonproteobacteria pldA GO:0003674,GO:0003824,GO:0004620,GO:0004623,GO:0005488,GO:0005509,GO:0005515,GO:0005575,GO:0005623,GO:0008970,GO:0009279,GO:0016020,GO:0016021,GO:0016298,GO:0016787,GO:0016788,GO:0019867,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031975,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044425,GO:0044462,GO:0044464,GO:0045203,GO:0046872,GO:0046983,GO:0052689,GO:0071944 3.1.1.32,3.1.1.4 ko:K01058 ko00564,ko00565,ko00590,ko00591,ko00592,ko01100,ko01110,map00564,map00565,map00590,map00591,map00592,map01100,map01110 R01315,R01316,R01317,R02053,R02054,R04034,R07064,R07379,R07387,R07859,R07860 RC00020,RC00037,RC00041,RC00094 ko00000,ko00001,ko01000 iEC042_1314.EC042_4201,iECUMN_1333.ECUMN_4347,iEcSMS35_1347.EcSMS35_4188 Bacteria 1PC8I@1224,2YNMK@29547,42R3P@68525,COG2829@1,COG2829@2 NA|NA|NA M phospholipase PFHLONEA_02245 1232437.KL662060_gene4112 4.9e-24 117.1 Desulfobacterales ygiN GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0009268,GO:0009628,GO:0010447,GO:0016491,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0055114 iEcSMS35_1347.EcSMS35_3317 Bacteria 1RE0B@1224,2MKZ9@213118,2WS9H@28221,42VE2@68525,COG1359@1,COG1359@2 NA|NA|NA S Antibiotic biosynthesis monooxygenase PFHLONEA_02246 243231.GSU2362 3.4e-46 191.4 Desulfuromonadales Bacteria 1RF8X@1224,2X5RZ@28221,43AC3@68525,43UX1@69541,COG1846@1,COG1846@2 NA|NA|NA K helix_turn_helix multiple antibiotic resistance protein PFHLONEA_02247 909663.KI867150_gene1328 1.2e-28 133.3 Deltaproteobacteria pal ko:K03640 ko00000,ko02000 2.C.1.2 Bacteria 1MZTV@1224,2WNZS@28221,42R5H@68525,COG2885@1,COG2885@2 NA|NA|NA M Belongs to the ompA family PFHLONEA_02249 1206731.BAGB01000063_gene7437 1.4e-31 142.1 Nocardiaceae ko:K09780 ko00000 Bacteria 2GS0M@201174,4G4G4@85025,COG2350@1,COG2350@2 NA|NA|NA S YCII-related domain PFHLONEA_02251 765912.Thimo_2942 9.7e-30 137.5 Chromatiales Bacteria 1RDMT@1224,1S4SQ@1236,1X05Z@135613,COG1985@1,COG1985@2 NA|NA|NA H RibD C-terminal domain PFHLONEA_02252 118161.KB235922_gene4767 2.5e-20 105.1 Bacteria Bacteria 2EI52@1,33BWE@2 NA|NA|NA PFHLONEA_02253 1121428.DESHY_30085___1 5.1e-154 550.8 Peptococcaceae dsrA 1.8.99.5 ko:K11180 ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120 M00596 R00295,R00861,R08035 RC00065,RC01760 ko00000,ko00001,ko00002,ko01000 Bacteria 1TRP0@1239,24A5T@186801,260BJ@186807,COG2221@1,COG2221@2 NA|NA|NA C PFAM nitrite and sulphite reductase 4Fe-4S PFHLONEA_02254 289376.THEYE_A1018 4.7e-38 164.1 Bacteria ko:K07397 ko00000 Bacteria COG1765@1,COG1765@2 NA|NA|NA O OsmC-like protein PFHLONEA_02255 330214.NIDE2975 1.1e-73 283.1 Nitrospirae cysE GO:0000096,GO:0000097,GO:0000098,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009001,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009070,GO:0009087,GO:0009987,GO:0016053,GO:0016054,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS02865,iYO844.BSU00930 Bacteria 3J11G@40117,COG1045@1,COG1045@2 NA|NA|NA E Serine acetyltransferase, N-terminal PFHLONEA_02257 1121428.DESHY_150012___1 1.1e-37 162.9 Peptococcaceae ispF GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006629,GO:0006720,GO:0006721,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008270,GO:0008299,GO:0008610,GO:0008685,GO:0009058,GO:0009108,GO:0009987,GO:0016114,GO:0016829,GO:0016849,GO:0030145,GO:0040007,GO:0042180,GO:0042181,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051483,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.1.1.228,2.7.7.60,4.6.1.12 ko:K00554,ko:K00991,ko:K01770,ko:K12506 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R00597,R05633,R05637 RC00002,RC00003,RC00334,RC01440 ko00000,ko00001,ko00002,ko01000,ko03016 iNJ661.Rv3581c,iPC815.YPO3360 Bacteria 1V3P0@1239,24HCM@186801,26109@186807,COG0245@1,COG0245@2 NA|NA|NA I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) PFHLONEA_02258 574087.Acear_0136 5.7e-57 227.6 Halanaerobiales ispD GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0050518,GO:0070567 2.7.7.60,4.6.1.12 ko:K00991,ko:K12506 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633,R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS20335 Bacteria 1V3M7@1239,248E6@186801,3WAMP@53433,COG1211@1,COG1211@2 NA|NA|NA I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) PFHLONEA_02259 1144275.COCOR_01949 4.8e-67 261.5 Myxococcales mglA GO:0008150,GO:0032879,GO:0032880,GO:0050789,GO:0065007 ko:K06883 ko00000 Bacteria 1R6NS@1224,2WJ44@28221,2YU2F@29,42NIX@68525,COG1100@1,COG1100@2 NA|NA|NA S ADP-ribosylation factor family PFHLONEA_02260 289376.THEYE_A0972 7.8e-53 214.2 Bacteria suhB 3.1.3.25,3.1.3.7 ko:K01082,ko:K01092 ko00521,ko00562,ko00920,ko01100,ko01120,ko01130,ko04070,map00521,map00562,map00920,map01100,map01120,map01130,map04070 M00131 R00188,R00508,R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000,ko03016 Bacteria COG0483@1,COG0483@2 NA|NA|NA G inositol monophosphate 1-phosphatase activity PFHLONEA_02261 443143.GM18_3636 1.1e-18 99.4 Bacteria Bacteria 2DRRJ@1,33CRQ@2 NA|NA|NA S Cytochrome c7 and related cytochrome c PFHLONEA_02263 864702.OsccyDRAFT_0469 1.7e-13 83.6 Oscillatoriales ko:K05516 ko00000,ko03036,ko03110 Bacteria 1G0RD@1117,1H8WF@1150,COG2214@1,COG2214@2,COG2319@1,COG2319@2 NA|NA|NA O Wd40 repeat-containing protein PFHLONEA_02264 1114964.L485_18805 5.4e-54 218.0 Sphingomonadales ko:K03733,ko:K14059 ko00000,ko03036 Bacteria 1MVZB@1224,2K9P4@204457,2UHUZ@28211,COG0582@1,COG0582@2 NA|NA|NA L Arm DNA-binding domain PFHLONEA_02267 1444770.AF72_02720 1.1e-59 237.3 Gammaproteobacteria Bacteria 1RJCW@1224,1SA06@1236,COG1835@1,COG1835@2 NA|NA|NA I Acyltransferase family PFHLONEA_02268 296591.Bpro_1646 2.8e-56 224.9 Proteobacteria Bacteria 1NH3X@1224,COG4319@1,COG4319@2 NA|NA|NA S SnoaL-like domain PFHLONEA_02269 1031711.RSPO_c02538 4.8e-34 150.2 Burkholderiaceae Bacteria 1K8WI@119060,1RB46@1224,2VTVP@28216,COG3832@1,COG3832@2 NA|NA|NA S Activator of Hsp90 ATPase homolog 1-like protein PFHLONEA_02270 760568.Desku_1814 3.4e-13 80.9 Clostridia Bacteria 1VNNZ@1239,24WH1@186801,2ETFK@1,33KZG@2 NA|NA|NA PFHLONEA_02271 264732.Moth_2011 5.5e-42 177.2 Firmicutes Bacteria 1V7GS@1239,COG5573@1,COG5573@2 NA|NA|NA S PFAM PilT protein domain protein PFHLONEA_02272 338966.Ppro_2737 7.1e-72 277.3 Desulfuromonadales surE GO:0003674,GO:0003824,GO:0004309,GO:0005488,GO:0005515,GO:0006139,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008254,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009125,GO:0009129,GO:0009131,GO:0009158,GO:0009161,GO:0009164,GO:0009166,GO:0009173,GO:0009175,GO:0009218,GO:0009222,GO:0009259,GO:0009261,GO:0009987,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030145,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042578,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046049,GO:0046050,GO:0046131,GO:0046133,GO:0046135,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 iSFxv_1172.SFxv_3035 Bacteria 1MVHE@1224,2WMUX@28221,42N0I@68525,43T33@69541,COG0496@1,COG0496@2 NA|NA|NA F Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates PFHLONEA_02273 1123371.ATXH01000005_gene2046 3e-65 255.0 Thermodesulfobacteria pcm GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 ko:K00573 ko00000,ko01000 Bacteria 2GH2E@200940,COG2518@1,COG2518@2 NA|NA|NA O Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins PFHLONEA_02274 195103.CPF_1280 5.7e-21 107.8 Clostridiaceae 3.6.1.27 ko:K19302 ko00550,map00550 R05627 RC00002 ko00000,ko00001,ko01000,ko01011 Bacteria 1VB7J@1239,24JDD@186801,36JV0@31979,COG0671@1,COG0671@2 NA|NA|NA I Membrane-associated phospholipid phosphatase PFHLONEA_02275 1123371.ATXH01000020_gene485 1.2e-32 146.4 Thermodesulfobacteria sun GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.176,2.1.1.178 ko:K03500,ko:K11392,ko:K21970 ko00000,ko01000,ko03009,ko03029 Bacteria 2GGSR@200940,COG0144@1,COG0144@2,COG0781@1,COG0781@2 NA|NA|NA J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA PFHLONEA_02276 439235.Dalk_0555 9.3e-26 124.0 Desulfobacterales 2.7.11.1 ko:K08884,ko:K12132 ko00000,ko01000,ko01001 Bacteria 1RINJ@1224,2MKCQ@213118,2WP1T@28221,42SZU@68525,COG2815@1,COG2815@2 NA|NA|NA S PASTA PFHLONEA_02277 1121918.ARWE01000001_gene153 1.2e-75 289.7 Desulfuromonadales rpe GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 iIT341.HP1386,iLJ478.TM1718 Bacteria 1MUZM@1224,2WJK9@28221,42NC0@68525,43TEV@69541,COG0036@1,COG0036@2 NA|NA|NA G Ribulose-phosphate 3 epimerase family PFHLONEA_02278 1123371.ATXH01000007_gene541 3e-222 778.1 Thermodesulfobacteria GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0036440,GO:0046912,GO:0050450 iHN637.CLJU_RS03250 Bacteria 2GHCY@200940,COG0119@1,COG0119@2 NA|NA|NA E Cache domain PFHLONEA_02279 118173.KB235914_gene4074 5e-83 315.5 Oscillatoriales Bacteria 1G0X9@1117,1H92B@1150,COG0661@1,COG0661@2 NA|NA|NA S Unusual protein kinase PFHLONEA_02280 1049564.TevJSym_af00670 2.8e-107 395.2 unclassified Gammaproteobacteria yeiM ko:K03317 ko00000 2.A.41 Bacteria 1J50C@118884,1MXXX@1224,1RMBX@1236,COG1972@1,COG1972@2 NA|NA|NA U Na+ dependent nucleoside transporter N-terminus PFHLONEA_02283 690850.Desaf_2977 1.1e-84 319.7 Desulfovibrionales yhhW ko:K06911 ko00000 Bacteria 1MWIP@1224,2M9ST@213115,2WJWB@28221,42N8V@68525,COG1741@1,COG1741@2 NA|NA|NA S Belongs to the pirin family PFHLONEA_02284 269799.Gmet_2569 1.9e-09 68.2 Desulfuromonadales Bacteria 1NHMH@1224,2EIC1@1,2WT9H@28221,33C3D@2,42WXS@68525,43VPD@69541 NA|NA|NA PFHLONEA_02285 643648.Slip_2086 2.6e-82 312.4 Clostridia ko:K07497 ko00000 Bacteria 1TSXX@1239,24C90@186801,COG2801@1,COG2801@2 NA|NA|NA L Transposase and inactivated derivatives PFHLONEA_02286 1121918.ARWE01000001_gene2221 4.4e-43 181.0 Deltaproteobacteria usp-3 Bacteria 1Q0M5@1224,2WVQA@28221,430YY@68525,COG0589@1,COG0589@2 NA|NA|NA T Universal stress protein family PFHLONEA_02287 1167006.UWK_00993 2.2e-21 109.0 Deltaproteobacteria ko:K03646 ko00000,ko02000 2.C.1.2 Bacteria 1R7D3@1224,2WT88@28221,42Y44@68525,COG3064@1,COG3064@2 NA|NA|NA M Membrane PFHLONEA_02289 909663.KI867151_gene3000 1.5e-101 375.9 Syntrophobacterales gpgS 2.4.1.266 ko:K13693 ko00000,ko01000,ko01003 GT81 Bacteria 1MWH9@1224,2MQYT@213462,2WJUG@28221,42PX0@68525,COG1215@1,COG1215@2 NA|NA|NA M COG0463 Glycosyltransferases involved in cell wall biogenesis PFHLONEA_02290 1121022.ABENE_23565 1.4e-118 433.0 Caulobacterales Bacteria 1MW7X@1224,2KHTR@204458,2TTH8@28211,COG3335@1,COG3335@2 NA|NA|NA L Winged helix-turn helix PFHLONEA_02291 330214.NIDE0399 9.7e-134 483.8 Nitrospirae pheT 6.1.1.20 ko:K01889,ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 3J0U7@40117,COG0072@1,COG0072@2 NA|NA|NA J B3/4 domain PFHLONEA_02292 1121121.KB894308_gene144 5.6e-42 177.9 Paenibacillaceae rsmE GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070042,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.193 ko:K09761 ko00000,ko01000,ko03009 Bacteria 1V1CT@1239,26RFE@186822,4HH8P@91061,COG1385@1,COG1385@2 NA|NA|NA J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit PFHLONEA_02293 316067.Geob_1233 1.1e-122 446.8 Desulfuromonadales pcnB 2.7.7.19,2.7.7.72 ko:K00970,ko:K00974 ko03013,ko03018,map03013,map03018 R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016,ko03019 Bacteria 1MVCS@1224,2WJ74@28221,42QKZ@68525,43TZA@69541,COG0617@1,COG0617@2 NA|NA|NA F Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control PFHLONEA_02294 909663.KI867150_gene1017 2.5e-38 164.9 Syntrophobacterales ko:K09143 ko00000 Bacteria 1N81P@1224,2MRZH@213462,2WVQQ@28221,430JJ@68525,COG2164@1,COG2164@2 NA|NA|NA S Cyclophilin-like PFHLONEA_02295 909663.KI867151_gene3154 3.3e-99 368.6 Deltaproteobacteria pcrA 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 ko00000,ko00001,ko01000,ko03400 Bacteria 1MU0G@1224,2WJR3@28221,42MKU@68525,COG0210@1,COG0210@2 NA|NA|NA L PFAM UvrD REP helicase PFHLONEA_02296 760568.Desku_1253 6.1e-38 164.1 Peptococcaceae rsmD GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052913,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.171 ko:K08316 R07234 RC00003 ko00000,ko01000,ko03009 Bacteria 1V3JF@1239,24JHR@186801,262G6@186807,COG0742@1,COG0742@2 NA|NA|NA L Methyltransferase PFHLONEA_02297 1379281.AVAG01000009_gene607 1.2e-48 199.5 Desulfovibrionales coaD GO:0003674,GO:0003824,GO:0004595,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0015939,GO:0015940,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046390,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 1RD9F@1224,2MBFU@213115,2WNDS@28221,42RJQ@68525,COG0669@1,COG0669@2 NA|NA|NA H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate PFHLONEA_02298 1128398.Curi_c08580 5.3e-42 177.9 unclassified Clostridiales spoU 2.1.1.185 ko:K03218,ko:K03437 ko00000,ko01000,ko03009,ko03016 Bacteria 1V3JP@1239,248DV@186801,268GU@186813,COG0566@1,COG0566@2 NA|NA|NA J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family PFHLONEA_02300 926561.KB900617_gene1705 5.6e-35 154.1 Halanaerobiales cymR GO:0001047,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0032991,GO:0032993,GO:0042802,GO:0042803,GO:0043933,GO:0044085,GO:0044212,GO:0046983,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051291,GO:0065003,GO:0071840,GO:0097159,GO:1901363 ko:K17472 ko00000,ko03000 Bacteria 1V3QB@1239,24JIV@186801,3WAQ6@53433,COG1959@1,COG1959@2 NA|NA|NA K TIGRFAM transcriptional regulator, Rrf2 family PFHLONEA_02301 439235.Dalk_1595 3.7e-91 342.0 Desulfobacterales mltA GO:0000270,GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008933,GO:0009056,GO:0009057,GO:0009253,GO:0009279,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016787,GO:0016798,GO:0019867,GO:0030203,GO:0030288,GO:0030312,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0042597,GO:0043170,GO:0044425,GO:0044459,GO:0044462,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 ko:K08304 ko00000,ko01000,ko01011 GH102 iECABU_c1320.ECABU_c30840 Bacteria 1MXD4@1224,2MIJE@213118,2WKKF@28221,42P7C@68525,COG2821@1,COG2821@2 NA|NA|NA M PFAM MltA PFHLONEA_02306 639282.DEFDS_0502 5.7e-14 84.3 Deferribacteres Bacteria 2DRTV@1,2GFUB@200930,33D1E@2 NA|NA|NA S Protein of unknown function (DUF2914) PFHLONEA_02307 1254432.SCE1572_33925 4.4e-62 244.6 Myxococcales dtpT ko:K03305 ko00000 2.A.17 Bacteria 1MW6W@1224,2WKK6@28221,2YTWP@29,42NNY@68525,COG3104@1,COG3104@2 NA|NA|NA E POT family PFHLONEA_02308 264732.Moth_1029 4.5e-65 254.2 Thermoanaerobacterales hslV GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016787,GO:0017076,GO:0019538,GO:0019904,GO:0022607,GO:0030163,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0051603,GO:0065003,GO:0070003,GO:0070011,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 3.4.25.2 ko:K01419 ko00000,ko01000,ko01002 Bacteria 1TPXK@1239,24FS4@186801,42G10@68295,COG5405@1,COG5405@2 NA|NA|NA O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery PFHLONEA_02309 316067.Geob_0753 4.2e-76 291.6 Desulfuromonadales xerC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 ko:K03733,ko:K04763 ko00000,ko03036 Bacteria 1QU6A@1224,2WJ08@28221,42Q4U@68525,43U9P@69541,COG4974@1,COG4974@2 NA|NA|NA D Phage integrase, N-terminal SAM-like domain PFHLONEA_02310 404589.Anae109_2693 2.1e-252 878.6 Myxococcales topA 5.99.1.2 ko:K03168 ko00000,ko01000,ko03032,ko03400 Bacteria 1MUFZ@1224,2WJTT@28221,2YU14@29,42MM9@68525,COG0550@1,COG0550@2 NA|NA|NA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone PFHLONEA_02311 1205908.AKXW01000128_gene492 4.9e-07 61.2 Vibrionales smg ko:K03747 ko00000 Bacteria 1RD5F@1224,1S43X@1236,1XTHN@135623,COG2922@1,COG2922@2 NA|NA|NA S Belongs to the Smg family PFHLONEA_02312 1220534.B655_1415 2.4e-78 299.7 Euryarchaeota Archaea 2Y7T3@28890,arCOG02348@1,arCOG02348@2157 NA|NA|NA T Histidine kinase PFHLONEA_02313 933262.AXAM01000002_gene504 4.7e-148 531.9 Desulfobacterales 2.7.13.3 ko:K02482,ko:K14986 ko02020,map02020 M00524 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 Bacteria 1NC9X@1224,2MI6A@213118,2X73B@28221,43BSJ@68525,COG0784@1,COG0784@2,COG5002@1,COG5002@2 NA|NA|NA T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PFHLONEA_02314 404380.Gbem_0305 4.6e-34 150.2 Proteobacteria Bacteria 1MWHF@1224,COG2885@1,COG2885@2 NA|NA|NA M Belongs to the ompA family PFHLONEA_02315 1267533.KB906736_gene956 6.4e-73 280.8 Bacteria ecaA 4.2.1.1 ko:K01674 ko00910,map00910 R00132,R10092 RC02807 ko00000,ko00001,ko01000 Bacteria COG3338@1,COG3338@2 NA|NA|NA P carbonate dehydratase activity PFHLONEA_02316 56780.SYN_02927 4.4e-47 195.7 delta/epsilon subdivisions Bacteria 1RBYV@1224,42TI1@68525,COG0666@1,COG0666@2 NA|NA|NA G PFAM Ankyrin PFHLONEA_02320 1163407.UU7_11864 3.2e-23 115.5 Bacteria ko:K04772 ko00000,ko01000,ko01002 Bacteria COG0265@1,COG0265@2 NA|NA|NA O serine-type endopeptidase activity PFHLONEA_02321 1121287.AUMU01000003_gene2814 7.8e-11 74.3 Chryseobacterium Bacteria 1I5IH@117743,2DPAX@1,331AI@2,3ZS1T@59732,4NV85@976 NA|NA|NA S PEGA domain PFHLONEA_02322 583355.Caka_0208 1.7e-25 122.9 Opitutae lpxK GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008654,GO:0009029,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019637,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046401,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.7.1.130 ko:K00912 ko00540,ko01100,map00540,map01100 M00060 R04657 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 iBWG_1329.BWG_0767,iECDH10B_1368.ECDH10B_0985,iPC815.YPO1396 Bacteria 3K7KP@414999,46SBI@74201,COG1663@1,COG1663@2 NA|NA|NA M Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) PFHLONEA_02323 1167006.UWK_02835 1e-49 203.4 Desulfobacterales hisB GO:0000105,GO:0000287,GO:0003674,GO:0003824,GO:0004401,GO:0004424,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034200,GO:0034641,GO:0042578,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.1.3.15,3.1.3.82,3.1.3.83,4.2.1.19 ko:K01089,ko:K03273 ko00340,ko00540,ko01100,ko01110,ko01230,map00340,map00540,map01100,map01110,map01230 M00026,M00064 R03013,R03457,R05647,R09771 RC00017,RC00932 ko00000,ko00001,ko00002,ko01000,ko01005 iECO111_1330.ECO111_2746,iECS88_1305.ECS88_2121,iUMNK88_1353.UMNK88_2570 Bacteria 1RDGR@1224,2MJSF@213118,2WPEA@28221,42SCB@68525,COG0241@1,COG0241@2 NA|NA|NA E D,D-heptose 1,7-bisphosphate phosphatase PFHLONEA_02324 338966.Ppro_2953 5.9e-107 394.4 Desulfuromonadales proB GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_3198 Bacteria 1MUBG@1224,2WIVS@28221,42NEA@68525,43SXM@69541,COG0263@1,COG0263@2 NA|NA|NA F Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate PFHLONEA_02325 1347087.CBYO010000007_gene1221 3.3e-17 95.1 Bacilli resA Bacteria 1VAPY@1239,4HIQ3@91061,COG0526@1,COG0526@2 NA|NA|NA CO Catalyzes the reduction of the disulfide bonds in the heme binding site of apocytochrome c PFHLONEA_02326 289376.THEYE_A0790 3.2e-146 525.0 Nitrospirae proA GO:0003674,GO:0003824,GO:0004350,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0018130,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0055114,GO:0055129,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.41,1.2.1.81 ko:K00147,ko:K15515 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 iB21_1397.B21_00243,iECBD_1354.ECBD_3376,iECB_1328.ECB_00240,iECD_1391.ECD_00240,iLJ478.TM0293,iNJ661.Rv2427c,iYL1228.KPN_00280,iYO844.BSU13130 Bacteria 3J0ET@40117,COG0014@1,COG0014@2 NA|NA|NA E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate PFHLONEA_02327 1304284.L21TH_2112 6.7e-47 194.1 Clostridiaceae nadD GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18,3.6.1.55 ko:K00969,ko:K03574 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 Bacteria 1V3SK@1239,24JFM@186801,36I7Z@31979,COG1057@1,COG1057@2 NA|NA|NA H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) PFHLONEA_02328 1123250.KB908389_gene2041 3.7e-26 124.4 Negativicutes rsfS GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113 2.7.7.18 ko:K00969,ko:K09710 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000,ko03009 Bacteria 1VA2Z@1239,4H585@909932,COG0799@1,COG0799@2 NA|NA|NA J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation PFHLONEA_02329 443143.GM18_4207 8.1e-28 130.2 Desulfuromonadales rlmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042802,GO:0042803,GO:0043021,GO:0043022,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0044877,GO:0046483,GO:0046983,GO:0070037,GO:0070038,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.177 ko:K00783 ko00000,ko01000,ko03009 Bacteria 1N7WB@1224,2X6IT@28221,42V41@68525,43UX0@69541,COG1576@1,COG1576@2 NA|NA|NA J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA PFHLONEA_02330 330214.NIDE1096 8.3e-65 254.6 Nitrospirae ko:K19804 ko00000 Bacteria 3J0KC@40117,COG2956@1,COG2956@2 NA|NA|NA G Tetratricopeptide repeat PFHLONEA_02331 290397.Adeh_0235 4.9e-173 614.4 Myxococcales gpmI GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030145,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0043937,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046537,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0050789,GO:0050793,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 iECSE_1348.ECSE_3895,iJN678.yibO,iJN746.PP_5056 Bacteria 1MUQ1@1224,2WJ66@28221,2YWA3@29,42N6C@68525,COG0696@1,COG0696@2 NA|NA|NA G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate PFHLONEA_02332 1379281.AVAG01000009_gene602 1.9e-65 256.1 Desulfovibrionales ko:K09860 ko00000 Bacteria 1R9S8@1224,2MC12@213115,2WP0N@28221,42RI7@68525,COG3018@1,COG3018@2 NA|NA|NA PFHLONEA_02334 1192034.CAP_0851 5.1e-37 162.2 Myxococcales prsK 4.6.1.1 ko:K01768,ko:K16648 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000,ko01003 Bacteria 1MVN6@1224,2X710@28221,2YU4V@29,43BPS@68525,COG1287@1,COG1287@2,COG2203@1,COG2203@2,COG3852@1,COG3852@2 NA|NA|NA T Signal transduction histidine kinase PFHLONEA_02335 1278073.MYSTI_04418 4.2e-112 411.8 Myxococcales atoC GO:0003674,GO:0003700,GO:0004857,GO:0006355,GO:0008073,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0010967,GO:0019219,GO:0019222,GO:0030234,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033238,GO:0042979,GO:0043086,GO:0044092,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 ko:K02481,ko:K07712,ko:K07714 ko02020,map02020 M00497,M00500 ko00000,ko00001,ko00002,ko02022 Bacteria 1MU0N@1224,2WIT0@28221,2YU4Y@29,42M03@68525,COG2204@1,COG2204@2 NA|NA|NA T Two component, sigma54 specific, transcriptional regulator, Fis family PFHLONEA_02341 868131.MSWAN_0881 1.2e-14 85.5 Methanobacteria Archaea 23PRY@183925,2Y11K@28890,COG4855@1,arCOG02570@2157 NA|NA|NA S Uncharacterized protein conserved in archaea (DUF2180) PFHLONEA_02342 667014.Thein_1492 3.8e-25 122.5 Bacteria 3.1.4.53 ko:K03651 ko00230,ko02025,map00230,map02025 R00191 RC00296 ko00000,ko00001,ko01000 Bacteria COG1409@1,COG1409@2 NA|NA|NA S acid phosphatase activity PFHLONEA_02343 316067.Geob_3391 1.5e-144 519.6 Desulfuromonadales rnr GO:0000175,GO:0003674,GO:0003724,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008408,GO:0008997,GO:0009056,GO:0009057,GO:0009266,GO:0009409,GO:0009628,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016896,GO:0017111,GO:0019222,GO:0019439,GO:0034458,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360,GO:1901361,GO:1901575 ko:K12573 ko03018,map03018 ko00000,ko00001,ko01000,ko03016,ko03019 Bacteria 1MUS6@1224,2WIWF@28221,42NGS@68525,43TQ3@69541,COG0557@1,COG0557@2 NA|NA|NA J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs PFHLONEA_02345 1499967.BAYZ01000084_gene3995 8.4e-109 401.0 unclassified Bacteria lnt ko:K03820 ko00000,ko01000 GT2 Bacteria 2NP0R@2323,COG0815@1,COG0815@2 NA|NA|NA M Carbon-nitrogen hydrolase PFHLONEA_02347 865861.AZSU01000003_gene1762 4.8e-10 71.2 Clostridiaceae hfq ko:K03666 ko02024,ko03018,ko05111,map02024,map03018,map05111 ko00000,ko00001,ko03019,ko03036 Bacteria 1VEGI@1239,24QIM@186801,36KQP@31979,COG1923@1,COG1923@2 NA|NA|NA J RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs PFHLONEA_02349 289376.THEYE_A0569 1.1e-35 156.0 Nitrospirae queD 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 Bacteria 3J0TW@40117,COG0720@1,COG0720@2 NA|NA|NA H 6-pyruvoyl tetrahydropterin synthase PFHLONEA_02350 269799.Gmet_0947 1.3e-97 363.6 Deltaproteobacteria pmbA ko:K03592 ko00000,ko01002 Bacteria 1MUVW@1224,2WN9N@28221,42RID@68525,COG0312@1,COG0312@2 NA|NA|NA S Peptidase U62 modulator of DNA gyrase PFHLONEA_02351 1487923.DP73_13575 3.2e-59 235.0 Peptococcaceae Bacteria 1V4SU@1239,24KYP@186801,262BI@186807,COG1280@1,COG1280@2 NA|NA|NA E PFAM Lysine exporter protein (LYSE YGGA) PFHLONEA_02352 289376.THEYE_A0186 1.2e-90 339.7 Nitrospirae lgt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008961,GO:0009249,GO:0009987,GO:0010467,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0031224,GO:0031226,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051604,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.1.1.199 ko:K03438,ko:K13292 ko00000,ko01000,ko03009 Bacteria 3J0G4@40117,COG0682@1,COG0682@2 NA|NA|NA M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins PFHLONEA_02354 1232410.KI421424_gene1723 3.9e-108 398.3 Desulfuromonadales dnaJ GO:0000988,GO:0000989,GO:0003674,GO:0003756,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006457,GO:0006458,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010556,GO:0015035,GO:0015036,GO:0016020,GO:0016032,GO:0016043,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0016989,GO:0019219,GO:0019222,GO:0022607,GO:0031323,GO:0031326,GO:0032991,GO:0034641,GO:0034645,GO:0042026,GO:0043167,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051704,GO:0055114,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0140096,GO:0140110,GO:1901360,GO:1901576,GO:1903506,GO:2001141 ko:K03686 ko00000,ko03029,ko03110 Bacteria 1MVMS@1224,2WJGP@28221,42KZM@68525,43SEG@69541,COG0484@1,COG0484@2 NA|NA|NA O DnaJ central domain PFHLONEA_02355 1144275.COCOR_02637 9.3e-30 136.3 Deltaproteobacteria Bacteria 1N1TA@1224,2WPZR@28221,42V03@68525,COG0745@1,COG0745@2 NA|NA|NA T cheY-homologous receiver domain PFHLONEA_02357 269799.Gmet_2313 7.1e-60 238.0 Desulfuromonadales Bacteria 1N9YT@1224,2WS2V@28221,42W15@68525,43T56@69541,COG0745@1,COG0745@2 NA|NA|NA T regulator, PATAN and FRGAF domain-containing PFHLONEA_02358 717605.Theco_2030 3e-55 221.5 Paenibacillaceae yajQ GO:0000049,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0009987,GO:0017076,GO:0019001,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033554,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0097159,GO:0097367,GO:1901265,GO:1901363 ko:K09767 ko00000 Bacteria 1V3UR@1239,26WQF@186822,4HHVD@91061,COG1666@1,COG1666@2 NA|NA|NA S Belongs to the UPF0234 family PFHLONEA_02359 1499967.BAYZ01000158_gene441 3.1e-20 105.5 unclassified Bacteria lolA ko:K03634 ko00000 Bacteria 2NQ6V@2323,COG2834@1,COG2834@2 NA|NA|NA M Outer membrane lipoprotein carrier protein LolA PFHLONEA_02360 243231.GSU3112 6.7e-168 597.8 Desulfuromonadales ftsK GO:0000920,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006950,GO:0006970,GO:0007059,GO:0008094,GO:0008150,GO:0009628,GO:0009651,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0015616,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033676,GO:0042221,GO:0042623,GO:0042802,GO:0043085,GO:0043565,GO:0044093,GO:0044425,GO:0044459,GO:0044464,GO:0045893,GO:0045935,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051301,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0070887,GO:0071236,GO:0071944,GO:0080090,GO:0097159,GO:0140097,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 ko:K03466 ko00000,ko03036 3.A.12 Bacteria 1MVPI@1224,2WIPR@28221,42N4X@68525,43UK2@69541,COG1674@1,COG1674@2 NA|NA|NA D PFAM cell divisionFtsK SpoIIIE PFHLONEA_02361 153948.NAL212_3187 2.9e-76 292.0 Nitrosomonadales uppP 3.6.1.27 ko:K06153 ko00550,map00550 R05627 RC00002 ko00000,ko00001,ko01000,ko01011 Bacteria 1MX02@1224,2VHSA@28216,371YI@32003,COG1968@1,COG1968@2 NA|NA|NA V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin PFHLONEA_02362 521011.Mpal_1544 6.3e-47 194.1 Archaea Archaea COG0491@1,arCOG00504@2157 NA|NA|NA S COG0491 Zn-dependent hydrolases, including glyoxylases PFHLONEA_02364 573061.Clocel_1208 9.9e-20 102.8 Bacteria 1.8.1.9 ko:K00384,ko:K01420 ko00450,map00450 R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000,ko03000 Bacteria COG0664@1,COG0664@2 NA|NA|NA T cyclic nucleotide binding PFHLONEA_02365 1121904.ARBP01000009_gene4301 4.4e-75 288.1 Cytophagia phuW Bacteria 47MCF@768503,4NEQ4@976,COG3016@1,COG3016@2 NA|NA|NA S Haem-binding uptake, Tiki superfamily, ChaN PFHLONEA_02366 1123376.AUIU01000014_gene515 5.1e-07 61.2 Bacteria Bacteria 2C9ST@1,2ZVIC@2 NA|NA|NA PFHLONEA_02367 706587.Desti_5611 7.2e-142 510.4 Syntrophobacterales metB 2.5.1.48,4.4.1.8 ko:K01739,ko:K01760 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04941,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00382,RC00420,RC00488,RC00710,RC01245,RC02303,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 Bacteria 1MU57@1224,2MQ8M@213462,2WJQX@28221,42M67@68525,COG0626@1,COG0626@2 NA|NA|NA E PFAM Cys Met metabolism PFHLONEA_02368 1396141.BATP01000023_gene598 1.2e-37 162.5 Verrucomicrobiae Bacteria 2IW0F@203494,46W1W@74201,COG0662@1,COG0662@2 NA|NA|NA G Cupin 2, conserved barrel domain protein PFHLONEA_02370 1499967.BAYZ01000014_gene6353 9.9e-152 543.5 unclassified Bacteria glgA GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 GT5 Bacteria 2NP1F@2323,COG0297@1,COG0297@2 NA|NA|NA G Synthesizes alpha-1,4-glucan chains using ADP-glucose PFHLONEA_02371 204669.Acid345_0343 6.2e-129 467.2 Acidobacteriia galT 2.7.7.12 ko:K00965 ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917 M00362,M00554,M00632 R00955 RC00002 ko00000,ko00001,ko00002,ko01000 iLJ478.TM0896 Bacteria 2JMKJ@204432,3Y41K@57723,COG1085@1,COG1085@2 NA|NA|NA C Domain of unknown function (DUF4921) PFHLONEA_02372 443144.GM21_3498 2.1e-18 99.0 Desulfuromonadales Bacteria 1N6KK@1224,2WQQS@28221,42TK4@68525,43VF7@69541,COG5512@1,COG5512@2 NA|NA|NA S Protein of unknown function (DUF721) PFHLONEA_02373 237368.SCABRO_01200 1.8e-56 225.7 Planctomycetes Bacteria 2J3BI@203682,COG5483@1,COG5483@2 NA|NA|NA S Protein of unknown function, DUF488 PFHLONEA_02376 1111730.ATTM01000006_gene2659 3.9e-32 145.2 Flavobacterium Bacteria 1IDTH@117743,2B93W@1,2NZ5X@237,322ES@2,4PDAH@976 NA|NA|NA PFHLONEA_02378 880072.Desac_0735 7.8e-145 520.4 Syntrophobacterales qmoA 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388,ko:K16885,ko:K16886 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 Bacteria 1Q0ZF@1224,2MQY4@213462,2WJ6M@28221,42NHH@68525,COG1148@1,COG1148@2 NA|NA|NA C FAD dependent oxidoreductase PFHLONEA_02379 289376.THEYE_A1832 4.7e-53 213.8 Nitrospirae aprA 1.8.99.2 ko:K00394 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00596 R00860,R04927,R08553 RC00007,RC01239,RC02862 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0YZ@40117,COG1053@1,COG1053@2 NA|NA|NA C FAD binding domain PFHLONEA_02380 525904.Tter_0805 4e-62 245.0 unclassified Bacteria gdhA 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2NNRJ@2323,COG0334@1,COG0334@2 NA|NA|NA E Belongs to the Glu Leu Phe Val dehydrogenases family PFHLONEA_02381 289376.THEYE_A0132 1.5e-40 172.2 Bacteria groS GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 ko:K04078 ko00000,ko03029,ko03110 Bacteria COG0234@1,COG0234@2 NA|NA|NA O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter PFHLONEA_02382 1121918.ARWE01000001_gene386 6.2e-301 1040.0 Deltaproteobacteria ko:K07263 ko00000,ko01000,ko01002 Bacteria 1MVST@1224,2WIPJ@28221,42NYP@68525,COG0612@1,COG0612@2 NA|NA|NA S Belongs to the peptidase M16 family PFHLONEA_02383 1144342.PMI40_04304 1.5e-52 212.6 Oxalobacteraceae sodC GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.15.1.1 ko:K04565 ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020 ko00000,ko00001,ko01000 Bacteria 1RGV4@1224,2VSTR@28216,477CG@75682,COG2032@1,COG2032@2 NA|NA|NA P Destroys radicals which are normally produced within the cells and which are toxic to biological systems PFHLONEA_02385 870187.Thini_0232 1.6e-44 186.0 Gammaproteobacteria Bacteria 1N1JR@1224,1SUCZ@1236,COG0727@1,COG0727@2 NA|NA|NA S Putative zinc- or iron-chelating domain PFHLONEA_02389 913865.DOT_1086 5.8e-54 218.0 Peptococcaceae cbiQ GO:0000041,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015675,GO:0016020,GO:0016021,GO:0030001,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 ko:K02007,ko:K02008 ko02010,map02010 M00245,M00246 ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 Bacteria 1V6BC@1239,24BI0@186801,266ZB@186807,COG0619@1,COG0619@2 NA|NA|NA P Cobalt transport protein PFHLONEA_02390 269797.Mbar_A2562 2.2e-74 286.2 Methanomicrobia ko:K02006 ko02010,map02010 M00245,M00246 ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 Archaea 2N9CJ@224756,2XVRT@28890,COG1122@1,arCOG00202@2157 NA|NA|NA E AAA domain, putative AbiEii toxin, Type IV TA system PFHLONEA_02391 679926.Mpet_0030 6.9e-43 180.6 Methanomicrobia 1.2.7.12 ko:K11261 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00567 R03015,R08060,R11743 RC00197,RC00323 ko00000,ko00001,ko00002,ko01000 Archaea 2N9IR@224756,2XWVF@28890,COG2191@1,arCOG00762@2157 NA|NA|NA C formylmethanofuran dehydrogenase, subunit E PFHLONEA_02392 243231.GSU1013 9.6e-42 177.2 Desulfuromonadales motB ko:K02557 ko02030,ko02040,map02030,map02040 ko00000,ko00001,ko02000,ko02035 1.A.30.1 Bacteria 1MU4S@1224,2WPPV@28221,42T2J@68525,43TEW@69541,COG1360@1,COG1360@2 NA|NA|NA M OmpA family PFHLONEA_02393 555088.DealDRAFT_2370 2.6e-56 225.3 Syntrophomonadaceae ribE GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 iYO844.BSU23270 Bacteria 1V1EP@1239,24FVK@186801,42JUW@68298,COG0307@1,COG0307@2 NA|NA|NA H Lumazine binding domain PFHLONEA_02394 243231.GSU1690 1.2e-161 576.2 Desulfuromonadales ribBA GO:0003674,GO:0003824,GO:0003933,GO:0003935,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0008686,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0016829,GO:0016830,GO:0017144,GO:0018130,GO:0019238,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 3.5.4.25,4.1.99.12 ko:K01497,ko:K02858,ko:K14652 ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS10830,iSB619.SA_RS08945 Bacteria 1MU8P@1224,2WIP5@28221,42N1C@68525,43U14@69541,COG0108@1,COG0108@2,COG0807@1,COG0807@2 NA|NA|NA H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate PFHLONEA_02395 555079.Toce_1692 4.6e-58 230.7 Thermoanaerobacterales ribH GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 iLJ478.TM1825,iSB619.SA_RS08940,iSFV_1184.SFV_0380 Bacteria 1V1DA@1239,24FRS@186801,42G01@68295,COG0054@1,COG0054@2 NA|NA|NA H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin PFHLONEA_02396 1156937.MFUM_720039 8.1e-24 116.7 unclassified Verrucomicrobia nusB ko:K03625 ko00000,ko03009,ko03021 Bacteria 37GZF@326457,46VCF@74201,COG0781@1,COG0781@2 NA|NA|NA K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons PFHLONEA_02397 1379698.RBG1_1C00001G1066 1.8e-09 69.3 unclassified Bacteria pepA GO:0001073,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006351,GO:0006355,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009056,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016787,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019538,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042150,GO:0043170,GO:0043171,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043244,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0097718,GO:0140096,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1903506,GO:2000112,GO:2001141 3.4.11.1,3.4.11.5 ko:K01255,ko:K01259 ko00330,ko00480,ko01100,map00330,map00480,map01100 R00135,R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 Bacteria 2NNKH@2323,COG0260@1,COG0260@2 NA|NA|NA E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides PFHLONEA_02398 316067.Geob_2894 6.4e-158 563.9 Desulfuromonadales purB GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 iLJ478.TM1095,iSB619.SA_RS09895 Bacteria 1MV4B@1224,2WJ2E@28221,42MYS@68525,43TS7@69541,COG0015@1,COG0015@2 NA|NA|NA F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily PFHLONEA_02399 1158318.ATXC01000001_gene223 6.6e-87 327.4 Aquificae rfbD 1.1.1.133,5.1.3.26 ko:K00067,ko:K19997 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 Bacteria 2G5FQ@200783,COG1091@1,COG1091@2 NA|NA|NA M RmlD substrate binding domain PFHLONEA_02400 523845.AQXV01000055_gene144 9.1e-69 266.5 Methanococci 5.1.3.13 ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R06514 RC01531 ko00000,ko00001,ko00002,ko01000 Archaea 23RBN@183939,2XVIP@28890,COG1898@1,arCOG04188@2157 NA|NA|NA M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose PFHLONEA_02401 247490.KSU1_D0779 2.1e-123 448.7 Planctomycetes rfbA GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0005996,GO:0006006,GO:0006139,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008879,GO:0009058,GO:0009059,GO:0009117,GO:0009141,GO:0009147,GO:0009200,GO:0009211,GO:0009219,GO:0009225,GO:0009226,GO:0009262,GO:0009394,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019299,GO:0019300,GO:0019305,GO:0019318,GO:0019319,GO:0019438,GO:0019637,GO:0019692,GO:0030312,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0045226,GO:0046075,GO:0046364,GO:0046379,GO:0046383,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 iNJ661.Rv0334 Bacteria 2IXSQ@203682,COG1209@1,COG1209@2 NA|NA|NA H Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis PFHLONEA_02402 330214.NIDE2553 1.1e-82 313.5 Nitrospirae rfaE 2.7.1.167,2.7.7.70 ko:K03272 ko00540,ko01100,map00540,map01100 M00064 R05644,R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 Bacteria 3J0GT@40117,COG2870@1,COG2870@2 NA|NA|NA M Phosphomethylpyrimidine kinase PFHLONEA_02403 1379698.RBG1_1C00001G1249 1.8e-36 159.8 unclassified Bacteria Bacteria 2NPQF@2323,COG3170@1,COG3170@2 NA|NA|NA NU Protein of unknown function (DUF3108) PFHLONEA_02404 932678.THERU_06340 3.2e-32 145.6 Aquificae Z012_07930 GO:0000270,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006807,GO:0008150,GO:0008152,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0030203,GO:0031224,GO:0042546,GO:0043164,GO:0043170,GO:0044085,GO:0044425,GO:0044464,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901564 Bacteria 2G45V@200783,COG1434@1,COG1434@2 NA|NA|NA S DUF218 domain PFHLONEA_02405 251229.Chro_2803 2.6e-42 178.3 Cyanobacteria badR ko:K15973 ko00000,ko03000 Bacteria 1G6XI@1117,COG1846@1,COG1846@2 NA|NA|NA K MarR family transcriptional PFHLONEA_02406 443144.GM21_0540 1.8e-43 182.2 Desulfuromonadales ko:K15977 ko00000 Bacteria 1RDYW@1224,2WVS2@28221,437IE@68525,43VBF@69541,COG2259@1,COG2259@2 NA|NA|NA S DoxX PFHLONEA_02407 1267535.KB906767_gene2350 4.5e-237 827.4 Acidobacteriia typA GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840 ko:K06207 ko00000 Bacteria 2JIIC@204432,3Y33Q@57723,COG1217@1,COG1217@2 NA|NA|NA T GTP-binding protein TypA PFHLONEA_02411 545264.KB898744_gene1965 1.8e-96 359.8 Chromatiales nla19 ko:K07713 ko02020,map02020 M00499 ko00000,ko00001,ko00002,ko02022 Bacteria 1MU0N@1224,1RMCK@1236,1WWGD@135613,COG2204@1,COG2204@2 NA|NA|NA T response regulator PFHLONEA_02412 247490.KSU1_C0290 1.2e-48 200.3 Planctomycetes kinE 2.7.13.3 ko:K02491,ko:K03406,ko:K07697 ko02020,ko02030,map02020,map02030 M00485 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 Bacteria 2J07R@203682,COG4191@1,COG4191@2,COG5000@1,COG5000@2 NA|NA|NA T PAS fold PFHLONEA_02414 1379698.RBG1_1C00001G0889 1.3e-32 146.0 unclassified Bacteria hom 1.1.1.3,1.1.1.399,1.1.1.95,4.3.1.19 ko:K00003,ko:K00058,ko:K01754,ko:K04767 ko00260,ko00270,ko00290,ko00300,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00290,map00300,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00017,M00018,M00020,M00570 R00220,R00996,R01513,R01773,R01775 RC00031,RC00087,RC00418,RC02600 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2NR4R@2323,COG4747@1,COG4747@2 NA|NA|NA S ACT domain protein PFHLONEA_02415 1121405.dsmv_1643 1e-43 183.0 Deltaproteobacteria osmC ko:K04063 ko00000 Bacteria 1RH9U@1224,2WQDD@28221,42TWN@68525,COG1764@1,COG1764@2 NA|NA|NA O OsmC-like protein PFHLONEA_02418 204669.Acid345_2958 9.5e-137 493.8 Acidobacteriia arsB 1.20.4.1 ko:K03325,ko:K03741 ko00000,ko01000,ko02000 2.A.59 Bacteria 2JHZG@204432,3Y431@57723,COG0798@1,COG0798@2 NA|NA|NA P Sodium Bile acid symporter family PFHLONEA_02419 269799.Gmet_2791 4e-97 361.3 Deltaproteobacteria arsM 2.1.1.137,2.1.1.79 ko:K00574,ko:K07755 ko00000,ko01000 Bacteria 1MVXN@1224,2WJIF@28221,42PQM@68525,COG0500@1,COG2226@2 NA|NA|NA Q UbiE COQ5 methyltransferase PFHLONEA_02420 243231.GSU2958 4.1e-55 221.5 Desulfuromonadales dsbD 1.8.1.8 ko:K04084,ko:K06196 ko00000,ko01000,ko02000,ko03110 5.A.1.1,5.A.1.2 Bacteria 1PK9S@1224,2WJPK@28221,42PV0@68525,43TDW@69541,COG4232@1,COG4232@2 NA|NA|NA CO Cytochrome C biogenesis protein transmembrane region PFHLONEA_02421 56780.SYN_01342 1.6e-101 375.9 Syntrophobacterales appC ko:K02034 ko02024,map02024 M00239 ko00000,ko00001,ko00002,ko02000 3.A.1.5 Bacteria 1MU26@1224,2MQ6J@213462,2WJ47@28221,42MFP@68525,COG1173@1,COG1173@2 NA|NA|NA P PFAM Binding-protein-dependent transport system inner membrane component PFHLONEA_02422 706587.Desti_5516 1e-107 396.7 Syntrophobacterales oppB ko:K02033,ko:K13894 ko02010,ko02024,map02010,map02024 M00239,M00349 ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.21,3.A.1.5.24 Bacteria 1NS80@1224,2MQBC@213462,2WIRR@28221,42N5D@68525,COG0601@1,COG0601@2 NA|NA|NA P PFAM Binding-protein-dependent transport system inner membrane component PFHLONEA_02426 909663.KI867150_gene1866 3e-281 974.2 Syntrophobacterales murC 6.3.2.4,6.3.2.8 ko:K01921,ko:K01924,ko:K19234,ko:K19236 ko00471,ko00473,ko00550,ko01100,ko01502,ko01503,map00471,map00473,map00550,map01100,map01502,map01503 R01150,R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01002,ko01011 Bacteria 1MV68@1224,2MR03@213462,2WK50@28221,42MMP@68525,COG0773@1,COG0773@2,COG1376@1,COG1376@2 NA|NA|NA M Belongs to the MurCDEF family PFHLONEA_02427 1121920.AUAU01000026_gene1474 0.0 1263.8 Acidobacteria MA20_13830 Bacteria 3Y35W@57723,COG0841@1,COG0841@2 NA|NA|NA V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family PFHLONEA_02429 1379698.RBG1_1C00001G0755 1.9e-100 372.5 unclassified Bacteria nadE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5,6.3.5.1 ko:K01916,ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00189,R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 Bacteria 2NNW4@2323,COG0171@1,COG0171@2,COG0388@1,COG0388@2 NA|NA|NA H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses PFHLONEA_02430 1121468.AUBR01000004_gene158 9.6e-75 287.0 Thermoanaerobacterales rsmI GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.198 ko:K07056 ko00000,ko01000,ko03009 Bacteria 1TP6U@1239,24864@186801,42F0X@68295,COG0313@1,COG0313@2 NA|NA|NA H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA PFHLONEA_02431 457570.Nther_2897 3e-103 382.1 Clostridia ko:K07138 ko00000 Bacteria 1TQAW@1239,247IS@186801,COG2768@1,COG2768@2 NA|NA|NA C binding domain protein PFHLONEA_02432 113395.AXAI01000006_gene1825 1.1e-16 92.4 Bradyrhizobiaceae Bacteria 1MWDV@1224,2TV51@28211,3JWDH@41294,COG2141@1,COG2141@2 NA|NA|NA C Luciferase-like monooxygenase PFHLONEA_02434 237368.SCABRO_02958 3.5e-118 431.8 Planctomycetes dinB 2.7.7.7 ko:K02346 ko00000,ko01000,ko03400 Bacteria 2IZ2I@203682,COG0389@1,COG0389@2 NA|NA|NA L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII PFHLONEA_02435 237368.SCABRO_02960 5.3e-18 96.7 Planctomycetes Bacteria 2EJQV@1,2J3W4@203682,33DFP@2 NA|NA|NA PFHLONEA_02436 927677.ALVU02000001_gene1034 7.2e-09 66.2 Synechocystis Bacteria 1G0SY@1117,1H57M@1142,COG5001@1,COG5001@2 NA|NA|NA T Putative diguanylate phosphodiesterase PFHLONEA_02437 1232410.KI421428_gene1126 2e-25 122.5 Desulfuromonadales ko:K07216 ko00000 Bacteria 1N8CS@1224,2WRTV@28221,42VDH@68525,43VEP@69541,COG2703@1,COG2703@2 NA|NA|NA P PFAM Hemerythrin HHE cation binding domain protein PFHLONEA_02438 247490.KSU1_C0953 3.3e-32 145.6 Planctomycetes Bacteria 2J1UK@203682,COG1456@1,COG1456@2 NA|NA|NA C Domain of unknown function (DUF3786) PFHLONEA_02439 289376.THEYE_A0344 1.1e-32 146.4 Nitrospirae GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 ko:K03617,ko:K08999 ko00000 Bacteria 3J0RC@40117,COG1259@1,COG1259@2 NA|NA|NA S Bifunctional nuclease PFHLONEA_02440 555079.Toce_1347 4.8e-52 211.1 Thermoanaerobacterales ubiX GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008694,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.5.1.129 ko:K03186,ko:K16875 ko00130,ko00365,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00365,map00627,map00940,map01100,map01110,map01120,map01220 M00117 R01238,R02952,R03367,R04985,R04986,R10213,R11225 RC00391,RC00814,RC03086,RC03392 ko00000,ko00001,ko00002,ko01000 iAF1260.b2311,iAF987.Gmet_3392,iAPECO1_1312.APECO1_4253,iB21_1397.B21_02196,iBWG_1329.BWG_2085,iE2348C_1286.E2348C_2451,iEC55989_1330.EC55989_2555,iECBD_1354.ECBD_1348,iECB_1328.ECB_02236,iECDH10B_1368.ECDH10B_2473,iECDH1ME8569_1439.ECDH1ME8569_2249,iECD_1391.ECD_02236,iECED1_1282.ECED1_2775,iECH74115_1262.ECH74115_3451,iECIAI39_1322.ECIAI39_2460,iECNA114_1301.ECNA114_2401,iECO103_1326.ECO103_2775,iECOK1_1307.ECOK1_2544,iECP_1309.ECP_2350,iECS88_1305.ECS88_2458,iECSE_1348.ECSE_2620,iECSF_1327.ECSF_2187,iECSP_1301.ECSP_3186,iECs_1301.ECs3195,iETEC_1333.ETEC_2447,iEcDH1_1363.EcDH1_1345,iEcE24377_1341.EcE24377A_2605,iEcHS_1320.EcHS_A2462,iEcSMS35_1347.EcSMS35_2467,iG2583_1286.G2583_2848,iJO1366.b2311,iJR904.b2311,iLF82_1304.LF82_2354,iNRG857_1313.NRG857_11705,iSDY_1059.SDY_2510,iUMN146_1321.UM146_05255,iUMNK88_1353.UMNK88_2862,iUTI89_1310.UTI89_C2595,iY75_1357.Y75_RS12120,iZ_1308.Z3573 Bacteria 1V3JV@1239,24HE5@186801,42GQQ@68295,COG0163@1,COG0163@2 NA|NA|NA H Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN PFHLONEA_02441 243231.GSU2744 1.8e-114 419.5 Deltaproteobacteria MA20_07500 Bacteria 1QWSX@1224,2X7FI@28221,43C55@68525,COG0477@1,COG0477@2 NA|NA|NA EGP MFS/sugar transport protein PFHLONEA_02442 671143.DAMO_0898 8.4e-82 310.5 unclassified Bacteria ubiA 2.5.1.39 ko:K03179 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R05000,R05615 RC00209,RC02895 ko00000,ko00001,ko00002,ko01000,ko01006 Bacteria 2NP4W@2323,COG0382@1,COG0382@2 NA|NA|NA H UbiA prenyltransferase family PFHLONEA_02443 1121920.AUAU01000006_gene400 1.8e-98 365.9 Acidobacteria rssA ko:K07001 ko00000 Bacteria 3Y5EY@57723,COG1752@1,COG1752@2 NA|NA|NA S Patatin-like phospholipase PFHLONEA_02444 224324.aq_999 2.5e-56 226.1 Aquificae fadD 2.3.1.51,6.2.1.3 ko:K00655,ko:K01897 ko00061,ko00071,ko00561,ko00564,ko01100,ko01110,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map00561,map00564,map01100,map01110,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086,M00089 R01280,R02241,R09381 RC00004,RC00014,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 Bacteria 2G3NC@200783,COG0204@1,COG0204@2,COG1022@1,COG1022@2 NA|NA|NA I PFAM AMP-dependent synthetase and ligase PFHLONEA_02445 56780.SYN_02485 8.8e-114 416.8 Deltaproteobacteria pacL 3.6.3.8,3.6.3.9 ko:K01537,ko:K01539 ko04022,ko04024,ko04260,ko04261,ko04911,ko04918,ko04919,ko04925,ko04960,ko04961,ko04964,ko04970,ko04971,ko04972,ko04973,ko04974,ko04976,ko04978,map04022,map04024,map04260,map04261,map04911,map04918,map04919,map04925,map04960,map04961,map04964,map04970,map04971,map04972,map04973,map04974,map04976,map04978 ko00000,ko00001,ko01000,ko04147 3.A.3.1,3.A.3.2 Bacteria 1MUU5@1224,2WIU0@28221,42M8F@68525,COG0474@1,COG0474@2 NA|NA|NA P ATPase, P-type (transporting), HAD superfamily, subfamily IC PFHLONEA_02446 555779.Dthio_PD3223 4e-22 112.1 Deltaproteobacteria metH 2.1.1.13,2.1.1.245,2.1.1.258 ko:K00197,ko:K00548,ko:K15023 ko00270,ko00450,ko00670,ko00680,ko00720,ko01100,ko01110,ko01120,ko01200,ko01230,map00270,map00450,map00670,map00680,map00720,map01100,map01110,map01120,map01200,map01230 M00017,M00357,M00377,M00422 R00946,R02289,R09096,R09365,R10219,R10243 RC00004,RC00035,RC00113,RC01144,RC01241,RC02871,RC02977 ko00000,ko00001,ko00002,ko01000 Bacteria 1MV6G@1224,2WIT3@28221,42Q13@68525,COG1410@1,COG1410@2 NA|NA|NA E PFAM dihydropteroate synthase, DHPS PFHLONEA_02447 243231.GSU3153 9.6e-69 267.3 Desulfuromonadales yccM-2 Bacteria 1MY5M@1224,2WMUV@28221,42QNC@68525,43UH6@69541,COG0348@1,COG0348@2 NA|NA|NA C 4Fe-4S binding domain PFHLONEA_02448 717231.Flexsi_0924 7.1e-65 254.2 Bacteria 3.6.3.16 ko:K01551,ko:K19171 ko00000,ko01000,ko02000,ko02048 3.A.19.1,3.A.21.1,3.A.4.1 Bacteria COG0003@1,COG0003@2 NA|NA|NA P Pfam Anion-transporting ATPase PFHLONEA_02449 269799.Gmet_0034 1.2e-104 386.7 Desulfuromonadales ko:K07098 ko00000 Bacteria 1MUH5@1224,2WKJY@28221,42N75@68525,43SDV@69541,COG1408@1,COG1408@2 NA|NA|NA S Calcineurin-like phosphoesterase PFHLONEA_02450 269799.Gmet_1640 1.6e-117 429.5 Desulfuromonadales pfkA 2.7.1.11,2.7.1.90 ko:K00850,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 iJN678.pfkA Bacteria 1MVN3@1224,2WJA1@28221,42Q5V@68525,43TVR@69541,COG0205@1,COG0205@2 NA|NA|NA F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis PFHLONEA_02451 1121468.AUBR01000008_gene2058 6.2e-37 161.4 Thermoanaerobacterales Bacteria 1TQQ0@1239,24EHA@186801,42GIK@68295,COG1228@1,COG1228@2 NA|NA|NA Q Amidohydrolase family PFHLONEA_02452 386456.JQKN01000008_gene1585 1.4e-12 78.6 Methanobacteria 1.2.3.3,1.2.5.1 ko:K00156,ko:K00158 ko00620,ko01100,map00620,map01100 R00207,R03145 RC00860,RC02745 ko00000,ko00001,ko01000 Archaea 23PYA@183925,2XWG6@28890,COG0028@1,COG1773@1,arCOG01999@2157,arCOG04391@2157 NA|NA|NA CG PFAM Thiamine pyrophosphate enzyme, C-terminal TPP-binding PFHLONEA_02453 909663.KI867150_gene1859 9.4e-167 593.2 Syntrophobacterales dfa1 ko:K12264 ko05132,map05132 ko00000,ko00001 Bacteria 1NDXY@1224,2MQWF@213462,2WJ8Z@28221,42N11@68525,COG0426@1,COG0426@2 NA|NA|NA C Metallo-beta-lactamase superfamily PFHLONEA_02454 667014.Thein_0098 1.6e-33 149.1 Thermodesulfobacteria fur ko:K03711,ko:K09825 ko00000,ko03000 Bacteria 2GI0A@200940,COG0735@1,COG0735@2 NA|NA|NA P Belongs to the Fur family PFHLONEA_02455 338963.Pcar_3130 3.8e-26 124.8 Desulfuromonadales atpC GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194 3.A.2.1 iHN637.CLJU_RS01195,iJN746.PP_5412,iSbBS512_1146.SbBS512_E4190 Bacteria 1RHE4@1224,2WPVK@28221,42TII@68525,43SJV@69541,COG0355@1,COG0355@2 NA|NA|NA C Produces ATP from ADP in the presence of a proton gradient across the membrane PFHLONEA_02456 639282.DEFDS_1886 3.1e-123 448.0 Deferribacteres atpD GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 e_coli_core.b3732,iAF1260.b3732,iAPECO1_1312.APECO1_2729,iB21_1397.B21_03560,iBWG_1329.BWG_3423,iE2348C_1286.E2348C_4042,iEC042_1314.EC042_4119,iEC55989_1330.EC55989_4207,iECABU_c1320.ECABU_c42160,iECBD_1354.ECBD_4300,iECB_1328.ECB_03616,iECDH10B_1368.ECDH10B_3919,iECDH1ME8569_1439.ECDH1ME8569_3620,iECD_1391.ECD_03616,iECED1_1282.ECED1_4422,iECH74115_1262.ECH74115_5168,iECIAI1_1343.ECIAI1_3916,iECIAI39_1322.ECIAI39_4336,iECNA114_1301.ECNA114_3881,iECO103_1326.ECO103_4426,iECO111_1330.ECO111_4566,iECO26_1355.ECO26_4846,iECOK1_1307.ECOK1_4181,iECP_1309.ECP_3931,iECS88_1305.ECS88_4154,iECSE_1348.ECSE_4022,iECSF_1327.ECSF_3580,iECSP_1301.ECSP_4782,iECUMN_1333.ECUMN_4262,iECW_1372.ECW_m4035,iECs_1301.ECs4674,iEKO11_1354.EKO11_4613,iETEC_1333.ETEC_4023,iEcDH1_1363.EcDH1_4235,iEcE24377_1341.EcE24377A_4247,iEcSMS35_1347.EcSMS35_4100,iEcolC_1368.EcolC_4262,iG2583_1286.G2583_4528,iJO1366.b3732,iJR904.b3732,iLF82_1304.LF82_0194,iNRG857_1313.NRG857_18585,iPC815.YPO4121,iSFV_1184.SFV_3758,iSF_1195.SF3812,iSFxv_1172.SFxv_4154,iSSON_1240.SSON_3887,iS_1188.S3956,iSbBS512_1146.SbBS512_E4189,iUMN146_1321.UM146_18850,iUMNK88_1353.UMNK88_4544,iUTI89_1310.UTI89_C4285,iWFL_1372.ECW_m4035,iY75_1357.Y75_RS18410,iZ_1308.Z5230,ic_1306.c4658 Bacteria 2GEQN@200930,COG0055@1,COG0055@2 NA|NA|NA C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits PFHLONEA_02457 330214.NIDE1304 1.3e-148 532.7 Nitrospirae rpoC GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03046,ko:K13797 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 Bacteria 3J0BT@40117,COG0086@1,COG0086@2 NA|NA|NA K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates PFHLONEA_02458 330214.NIDE1306 1.8e-57 228.4 Nitrospirae rpsL GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02950 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 3J0IU@40117,COG0048@1,COG0048@2 NA|NA|NA J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit PFHLONEA_02459 378806.STAUR_3734 1.5e-53 215.7 Myxococcales rpsG GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0016020,GO:0016043,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 ko:K02992 ko03010,map03010 M00178,M00179 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1MXC8@1224,2WNFM@28221,2YUYC@29,42QR7@68525,COG0049@1,COG0049@2 NA|NA|NA J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA PFHLONEA_02460 243231.GSU2860 1.2e-304 1052.0 Deltaproteobacteria fusA GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02355 ko00000,ko03012,ko03029 Bacteria 1MUCV@1224,2WIM7@28221,42M4T@68525,COG0480@1,COG0480@2 NA|NA|NA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome PFHLONEA_02461 644968.DFW101_2882 1.2e-13 82.8 Desulfovibrionales Bacteria 1Q0MA@1224,2AI6Z@1,2MEUD@213115,2X1DQ@28221,318MA@2,43EQP@68525 NA|NA|NA PFHLONEA_02463 1007105.PT7_1573 1.1e-75 290.0 Betaproteobacteria Bacteria 1MVHC@1224,2VHPJ@28216,COG1638@1,COG1638@2 NA|NA|NA G TIGRFAM TRAP dicarboxylate transporter, DctP subunit PFHLONEA_02464 1131269.AQVV01000007_gene1038 1.1e-120 440.7 Bacteria mutL GO:0000018,GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0032300,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1990391 2.1.1.37 ko:K00558,ko:K03572 ko00270,ko01100,ko03430,ko05206,map00270,map01100,map03430,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036,ko03400 Bacteria COG0323@1,COG0323@2 NA|NA|NA L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex PFHLONEA_02465 395495.Lcho_3292 4e-80 304.7 unclassified Burkholderiales ygdQ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 1KKPM@119065,1MWC9@1224,2VJSY@28216,COG0861@1,COG0861@2 NA|NA|NA P Integral membrane protein TerC family PFHLONEA_02466 335543.Sfum_1920 1.2e-76 293.5 Syntrophobacterales miaA GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 Bacteria 1MUB2@1224,2MQEE@213462,2WIUB@28221,42M7V@68525,COG0324@1,COG0324@2 NA|NA|NA J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) PFHLONEA_02467 335541.Swol_0980 3.2e-19 100.9 Syntrophomonadaceae hfq ko:K03666 ko02024,ko03018,ko05111,map02024,map03018,map05111 ko00000,ko00001,ko03019,ko03036 Bacteria 1VEGI@1239,24QIM@186801,42K4T@68298,COG1923@1,COG1923@2 NA|NA|NA J RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs PFHLONEA_02468 237368.SCABRO_03752 1e-101 376.7 Planctomycetes mtnP GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004731,GO:0006082,GO:0006139,GO:0006144,GO:0006168,GO:0006520,GO:0006555,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009112,GO:0009113,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0017061,GO:0017144,GO:0018130,GO:0019438,GO:0019509,GO:0019752,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0055086,GO:0071265,GO:0071267,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.28 ko:K00772 ko00270,ko01100,map00270,map01100 M00034 R01402 RC00063,RC02819 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2684 Bacteria 2IZAA@203682,COG0005@1,COG0005@2 NA|NA|NA F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate PFHLONEA_02469 443143.GM18_1489 1.2e-115 422.9 Desulfuromonadales adoK GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004001,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005975,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019200,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032552,GO:0032553,GO:0032554,GO:0032555,GO:0032559,GO:0032560,GO:0032561,GO:0032567,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046390,GO:0046483,GO:0046835,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.15,2.7.1.20 ko:K00852,ko:K00856 ko00030,ko00230,ko01100,map00030,map00230,map01100 R00185,R01051,R02750 RC00002,RC00017 ko00000,ko00001,ko01000 iAF987.Gmet_2683 Bacteria 1Q8Y3@1224,2WJWD@28221,42NSV@68525,43S1S@69541,COG0524@1,COG0524@2 NA|NA|NA H PFAM PfkB domain protein PFHLONEA_02473 565033.GACE_2082 4.2e-33 147.9 Archaeoglobi ko:K02003 M00258 ko00000,ko00002,ko02000 3.A.1 Archaea 2460M@183980,2XUH3@28890,COG1136@1,arCOG00922@2157 NA|NA|NA E ABC transporter PFHLONEA_02474 247490.KSU1_C1282 7.1e-40 171.4 Planctomycetes Bacteria 28K4S@1,2J1UP@203682,30U3F@2 NA|NA|NA PFHLONEA_02476 404380.Gbem_2784 2.6e-12 77.4 Deltaproteobacteria Bacteria 1MWSG@1224,2WK4Q@28221,42NC8@68525,COG2358@1,COG2358@2 NA|NA|NA S TRAP transporter solute receptor TAXI family PFHLONEA_02477 247490.KSU1_C1307 3.1e-228 798.1 Planctomycetes treY GO:0000272,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009251,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0030978,GO:0030980,GO:0034637,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0047470,GO:0071704,GO:1901575,GO:1901576 2.4.1.25,5.4.99.15 ko:K00705,ko:K06044 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01824,R05196,R09995 RC00049 ko00000,ko00001,ko00002,ko01000 GH13,GH77 Bacteria 2IYFT@203682,COG3280@1,COG3280@2 NA|NA|NA G Alpha amylase, catalytic domain PFHLONEA_02480 1499967.BAYZ01000027_gene1802 1.1e-110 407.1 unclassified Bacteria fadD 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 Bacteria 2NPH9@2323,COG0318@1,COG0318@2 NA|NA|NA IQ COGs COG0318 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II PFHLONEA_02481 316067.Geob_2063 3e-25 122.5 Bacteria ko:K07052 ko00000 Bacteria COG1266@1,COG1266@2 NA|NA|NA V CAAX protease self-immunity PFHLONEA_02482 338966.Ppro_2348 1.3e-242 846.3 Desulfuromonadales hrpB 3.6.4.13 ko:K03579 ko00000,ko01000 Bacteria 1MUEQ@1224,2WJ7Z@28221,42MD4@68525,43S5U@69541,COG1643@1,COG1643@2 NA|NA|NA L TIGRFAM ATP-dependent helicase HrpB PFHLONEA_02485 1123376.AUIU01000016_gene198 2.6e-91 342.4 Bacteria Bacteria COG0535@1,COG0535@2 NA|NA|NA I radical SAM domain protein PFHLONEA_02486 289376.THEYE_A0985 4.8e-23 113.6 Bacteria ko:K11179 ko04122,map04122 ko00000,ko00001,ko01000,ko03016 Bacteria COG2920@1,COG2920@2 NA|NA|NA P part of a sulfur-relay system PFHLONEA_02487 289376.THEYE_A1598 1.1e-46 193.0 Bacteria Bacteria COG1633@1,COG1633@2 NA|NA|NA S Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) PFHLONEA_02488 1232437.KL662010_gene1569 1.2e-37 162.5 Desulfobacterales Bacteria 1N56C@1224,2MKGU@213118,2WQ0G@28221,42TK7@68525,COG1433@1,COG1433@2 NA|NA|NA S Dinitrogenase iron-molybdenum cofactor PFHLONEA_02489 177439.DP2820 2.6e-15 87.4 Deltaproteobacteria Bacteria 1N80T@1224,2WSGS@28221,42WDZ@68525,COG1342@1,COG1342@2 NA|NA|NA S Protein of unknown function DUF134 PFHLONEA_02490 1382359.JIAL01000001_gene2207 1.8e-35 155.6 Acidobacteriia Bacteria 2JN0N@204432,3Y5NG@57723,COG2905@1,COG2905@2 NA|NA|NA T Domain in cystathionine beta-synthase and other proteins. PFHLONEA_02492 1121918.ARWE01000001_gene1941 1.5e-65 256.9 Desulfuromonadales lptF ko:K07091,ko:K11720 ko02010,map02010 M00320 ko00000,ko00001,ko00002,ko02000 1.B.42.1 Bacteria 1MUF2@1224,2WKHT@28221,42NYD@68525,43S9U@69541,COG0795@1,COG0795@2 NA|NA|NA S Predicted permease YjgP/YjgQ family PFHLONEA_02493 443143.GM18_0414 9.6e-64 250.4 Desulfuromonadales Bacteria 1NSPR@1224,2EWA0@1,2WTJI@28221,33PNR@2,42YN1@68525,43U3D@69541 NA|NA|NA PFHLONEA_02494 102129.Lepto7375DRAFT_7834 8.6e-14 83.6 Oscillatoriales estC Bacteria 1G7M4@1117,1HFRE@1150,COG0596@1,COG0596@2 NA|NA|NA S Serine aminopeptidase, S33 PFHLONEA_02495 880073.Calab_1228 3e-22 112.5 unclassified Bacteria Bacteria 2NPR2@2323,COG3634@1,COG3634@2 NA|NA|NA O Thioredoxin domain PFHLONEA_02497 398767.Glov_1291 4.7e-07 61.6 Deltaproteobacteria ko:K02569,ko:K15876 ko00910,ko01120,map00910,map01120 M00530 R05712 RC00176 ko00000,ko00001,ko00002 Bacteria 1Q3YK@1224,2WT27@28221,42Y1M@68525,COG3005@1,COG3005@2 NA|NA|NA C denitrification pathway PFHLONEA_02499 767817.Desgi_1521 2e-10 71.2 Peptococcaceae tatA GO:0008150,GO:0040007 ko:K03116 ko03060,ko03070,map03060,map03070 M00336 ko00000,ko00001,ko00002,ko02044 2.A.64 Bacteria 1TV3X@1239,259BA@186801,2639X@186807,COG1826@1,COG1826@2 NA|NA|NA U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system PFHLONEA_02501 644968.DFW101_2310 2.2e-87 329.3 Desulfovibrionales Bacteria 1MW8M@1224,2MAKU@213115,2WMVR@28221,42R77@68525,COG0642@1,COG2205@2 NA|NA|NA T PhoQ Sensor PFHLONEA_02502 909663.KI867150_gene2777 9.4e-35 153.3 Deltaproteobacteria ko:K03733,ko:K04763 ko00000,ko03036 Bacteria 1RCN8@1224,2WMVF@28221,42RD9@68525,COG0582@1,COG0582@2 NA|NA|NA L viral genome integration into host DNA PFHLONEA_02503 926692.AZYG01000028_gene1788 6e-121 440.7 Halanaerobiales trpS GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 1TPY7@1239,248RC@186801,3WADX@53433,COG0180@1,COG0180@2 NA|NA|NA J PFAM tRNA synthetases class I (W and Y) PFHLONEA_02504 991.IW20_25730 3.9e-33 148.7 Flavobacterium ko:K07124 ko00000 Bacteria 1IMIN@117743,2NTWH@237,4NKNE@976,COG0300@1,COG0300@2 NA|NA|NA S Belongs to the short-chain dehydrogenases reductases (SDR) family PFHLONEA_02505 690850.Desaf_3311 3.3e-91 341.7 Desulfovibrionales paaK-2 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 R02539 RC00004,RC00014 ko00000,ko00001,ko01000 iAF987.Gmet_1825 Bacteria 1MV1W@1224,2M81G@213115,2WIWV@28221,42NKD@68525,COG1541@1,COG1541@2 NA|NA|NA H Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) PFHLONEA_02506 1198452.Jab_2c03890 5.1e-41 174.9 Betaproteobacteria Bacteria 1N2S6@1224,29WJ3@1,2WGA2@28216,30I5B@2 NA|NA|NA S Putative beta-barrel porin-2, OmpL-like. bbp2 PFHLONEA_02508 1232410.KI421426_gene1359 2.9e-96 359.0 Desulfuromonadales Bacteria 1MU48@1224,2WJ2A@28221,42MQ0@68525,43SE5@69541,COG0841@1,COG0841@2 NA|NA|NA V AcrB/AcrD/AcrF family PFHLONEA_02510 56780.SYN_00737 5.1e-26 124.4 Syntrophobacterales slp GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0016020,GO:0019867,GO:0042802 ko:K07285 ko00000 Bacteria 1MZ8C@1224,2MSI1@213462,2WQIC@28221,42TQE@68525,COG3065@1,COG3065@2 NA|NA|NA M Outer membrane lipoprotein Slp family PFHLONEA_02512 386456.JQKN01000016_gene914 3.5e-79 301.2 Euryarchaeota Archaea 2XT8P@28890,COG2249@1,arCOG02577@2157 NA|NA|NA H NADPH-quinone reductase (modulator of drug activity B) PFHLONEA_02513 767817.Desgi_0205 5.9e-52 210.3 Bacteria Bacteria COG0826@1,COG0826@2 NA|NA|NA O peptidase U32 PFHLONEA_02514 338963.Pcar_1339 1.7e-113 416.0 Deltaproteobacteria Bacteria 1NHDW@1224,28IWG@1,2WMMN@28221,2Z8US@2,42MHT@68525 NA|NA|NA S Predicted membrane protein (DUF2157) PFHLONEA_02515 289376.THEYE_A1688 5.7e-58 230.7 Nitrospirae dsrL 1.18.1.2,1.19.1.1,1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K00528,ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R10159,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 Bacteria 3J152@40117,COG0070@1,COG0070@2,COG0493@1,COG0493@2,COG1143@1,COG1143@2 NA|NA|NA C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster PFHLONEA_02516 391937.NA2_07879 1.5e-74 286.6 Phyllobacteriaceae dhaA GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006805,GO:0008150,GO:0008152,GO:0009056,GO:0009410,GO:0009987,GO:0016020,GO:0016787,GO:0016824,GO:0018786,GO:0019120,GO:0030312,GO:0042178,GO:0042197,GO:0042206,GO:0042221,GO:0042802,GO:0044237,GO:0044248,GO:0044464,GO:0050896,GO:0051716,GO:0070887,GO:0071466,GO:0071704,GO:0071944,GO:1901575 3.8.1.5 ko:K01563 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 R05284,R05367,R05368,R05369,R05370,R07669,R07670 RC01317,RC01340,RC01341,RC02013 ko00000,ko00001,ko01000 Bacteria 1R4ZX@1224,2TU6R@28211,43PBS@69277,COG0596@1,COG0596@2 NA|NA|NA S Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons PFHLONEA_02518 945713.IALB_3108 4.7e-44 184.5 Bacteria cccE Bacteria COG2010@1,COG2010@2 NA|NA|NA C Cytochrome c PFHLONEA_02519 56780.SYN_00323 1.9e-126 459.1 Deltaproteobacteria rip3 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 ko:K06212 ko00000,ko02000 1.A.16.1.1,1.A.16.1.3 Bacteria 1MY9R@1224,2WN7S@28221,42R1V@68525,COG0517@1,COG0517@2,COG1994@1,COG1994@2 NA|NA|NA K Belongs to the peptidase M50B family PFHLONEA_02520 211165.AJLN01000116_gene3381 9.6e-23 113.2 Cyanobacteria ko:K08978 ko00000,ko02000 2.A.7.2 Bacteria 1GACA@1117,COG2510@1,COG2510@2 NA|NA|NA S EamA-like transporter family PFHLONEA_02521 1380394.JADL01000009_gene3149 8.4e-45 186.8 Rhodospirillales 3.6.1.55 ko:K03574 ko00000,ko01000,ko03400 Bacteria 1RHCE@1224,2JWUA@204441,2U8N1@28211,COG4119@1,COG4119@2 NA|NA|NA L NUDIX domain PFHLONEA_02522 644282.Deba_0053 2.1e-27 129.8 Deltaproteobacteria Bacteria 1N47P@1224,2WSBM@28221,42W9J@68525,COG2202@1,COG2202@2 NA|NA|NA T PAS fold PFHLONEA_02523 589865.DaAHT2_1704 1.2e-29 136.0 Desulfobacterales dksA ko:K06204 ko02026,map02026 ko00000,ko00001,ko03000,ko03009,ko03021 Bacteria 1RD08@1224,2MJSM@213118,2WNNA@28221,42RVK@68525,COG1734@1,COG1734@2 NA|NA|NA T Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters PFHLONEA_02524 316067.Geob_1412 2.3e-39 169.1 Desulfuromonadales yfcN GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363 Bacteria 1RH34@1224,2WQG8@28221,42TQG@68525,43UXD@69541,COG2840@1,COG2840@2 NA|NA|NA S Smr domain PFHLONEA_02525 390874.Tpet_1602 1e-154 553.1 Bacteria icd GO:0000287,GO:0003674,GO:0003824,GO:0004448,GO:0004450,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006102,GO:0008150,GO:0008152,GO:0008270,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0016999,GO:0017144,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044464,GO:0045333,GO:0046487,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:0072350 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria COG0538@1,COG0538@2 NA|NA|NA C isocitrate dehydrogenase activity PFHLONEA_02527 477974.Daud_0348 3.1e-149 535.4 Peptococcaceae ppaC 3.6.1.1 ko:K15986 ko00190,map00190 ko00000,ko00001,ko01000 Bacteria 1TPH6@1239,248RQ@186801,260EW@186807,COG0517@1,COG0517@2,COG1227@1,COG1227@2 NA|NA|NA C DHHA2 domain PFHLONEA_02528 1232410.KI421418_gene2391 2.8e-68 265.8 Desulfuromonadales 2.1.1.80,2.7.13.3,3.1.1.61 ko:K07708,ko:K13924 ko02020,ko02030,map02020,map02030 M00497,M00506 ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 Bacteria 1NR54@1224,2WU15@28221,42YYW@68525,43TG5@69541,COG3852@1,COG3852@2 NA|NA|NA T His Kinase A (phosphoacceptor) domain PFHLONEA_02529 243231.GSU1989 3.3e-149 535.0 Desulfuromonadales atoC ko:K07713,ko:K07714 ko02020,map02020 M00499,M00500 ko00000,ko00001,ko00002,ko02022 Bacteria 1MU0N@1224,2WTMT@28221,42Z13@68525,43UA4@69541,COG2204@1,COG2204@2 NA|NA|NA T Bacterial regulatory protein, Fis family PFHLONEA_02530 243231.GSU1939 3.4e-189 668.3 Desulfuromonadales 2.7.13.3 ko:K02482 ko00000,ko01000,ko01001,ko02022 Bacteria 1NSAV@1224,2WURV@28221,42Z68@68525,43U68@69541,COG0642@1,COG2203@1,COG2203@2,COG2205@2,COG2206@1,COG2206@2 NA|NA|NA T Domains GAF, HisKA, HATPase_c, GAF, HD-GYP-related PFHLONEA_02531 237368.SCABRO_00284 5.9e-92 344.0 Planctomycetes 1.1.1.136 ko:K02474,ko:K13015 ko00520,map00520 R00421,R06894 RC00291 ko00000,ko00001,ko01000,ko01005 Bacteria 2IXVX@203682,COG0677@1,COG0677@2 NA|NA|NA M Belongs to the UDP-glucose GDP-mannose dehydrogenase family PFHLONEA_02533 1041930.Mtc_0697 3.1e-79 302.0 Methanomicrobia ssuA ko:K02051 M00188 ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 Archaea 2NAA1@224756,2XWEK@28890,COG0715@1,arCOG01803@2157 NA|NA|NA P NMT1-like family PFHLONEA_02534 1123376.AUIU01000012_gene1478 6.2e-118 431.4 Bacteria 1.1.1.399,1.1.1.95,4.3.1.19 ko:K00058,ko:K01754,ko:K04767 ko00260,ko00290,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00290,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00020,M00570 R00220,R00996,R01513 RC00031,RC00418,RC02600 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria COG0491@1,COG0491@2,COG4747@1,COG4747@2 NA|NA|NA GM Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid PFHLONEA_02535 1304885.AUEY01000103_gene2294 1.3e-25 122.5 Deltaproteobacteria Bacteria 1NBYS@1224,2WS01@28221,42VJA@68525,COG0607@1,COG0607@2 NA|NA|NA P SMART Rhodanese domain protein PFHLONEA_02537 1123376.AUIU01000016_gene232 6e-15 87.4 Bacteria Bacteria COG1196@1,COG1196@2 NA|NA|NA D nuclear chromosome segregation PFHLONEA_02538 1123376.AUIU01000016_gene233 7.9e-183 646.7 Nitrospirae yfhA GO:0000156,GO:0000160,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001130,GO:0001150,GO:0001151,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0023052,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035326,GO:0035556,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060089,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 ko:K07715 ko02020,ko02024,map02020,map02024 M00502 ko00000,ko00001,ko00002,ko02022 Bacteria 3J0ZU@40117,COG2204@1,COG2204@2 NA|NA|NA T Bacterial regulatory protein, Fis family PFHLONEA_02541 330214.NIDE2578 7.7e-59 234.2 Bacteria Bacteria 2F9RH@1,3421I@2 NA|NA|NA PFHLONEA_02542 1392502.JNIO01000008_gene1581 4.3e-149 534.6 Negativicutes ffh GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 Bacteria 1TP06@1239,4H29G@909932,COG0541@1,COG0541@2 NA|NA|NA U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY PFHLONEA_02543 986075.CathTA2_1873 8.1e-28 129.4 Bacilli rpsP GO:0000028,GO:0000217,GO:0000400,GO:0003674,GO:0003676,GO:0003677,GO:0003735,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006259,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016787,GO:0016788,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02959 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011,ko03029 Bacteria 1VA0X@1239,4HKNN@91061,COG0228@1,COG0228@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bS16 family PFHLONEA_02544 574087.Acear_1666 2.2e-29 135.6 Halanaerobiales rimM GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 ko:K02860 ko00000,ko03009 Bacteria 1V6HD@1239,24I1G@186801,3WATS@53433,COG0806@1,COG0806@2 NA|NA|NA J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes PFHLONEA_02545 656519.Halsa_1365 6.5e-78 297.4 Halanaerobiales trmD GO:0000287,GO:0001510,GO:0002939,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050518,GO:0052906,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228,4.6.1.12 ko:K00554,ko:K01770 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R00597,R05637 RC00002,RC00003,RC00334,RC01440 ko00000,ko00001,ko00002,ko01000,ko03016 Bacteria 1TPBV@1239,247JF@186801,3WB3E@53433,COG0336@1,COG0336@2 NA|NA|NA J Belongs to the RNA methyltransferase TrmD family PFHLONEA_02546 1392502.JNIO01000008_gene2344 3.8e-37 161.0 Negativicutes rplS GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 ko:K02884 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V6FT@1239,4H4PC@909932,COG0335@1,COG0335@2 NA|NA|NA J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site PFHLONEA_02547 404380.Gbem_3412 1.1e-34 153.3 Desulfuromonadales resA Bacteria 1N726@1224,2WQRF@28221,42U61@68525,43UYU@69541,COG0526@1,COG0526@2 NA|NA|NA CO Thioredoxin-like PFHLONEA_02548 667014.Thein_0765 2e-49 203.4 Thermodesulfobacteria mrcB 2.4.1.129,3.4.16.4 ko:K05365,ko:K05366,ko:K21464 ko00550,ko01100,ko01501,map00550,map01100,map01501 R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 GT51 iAF987.Gmet_1671 Bacteria 2GHEW@200940,COG0744@1,COG0744@2 NA|NA|NA M Transglycosylase PFHLONEA_02549 404589.Anae109_0719 5e-192 678.7 Myxococcales smc ko:K03529 ko00000,ko03036 Bacteria 1MUAQ@1224,2WJZF@28221,2YU45@29,42MN9@68525,COG1196@1,COG1196@2 NA|NA|NA D Required for chromosome condensation and partitioning PFHLONEA_02550 1499967.BAYZ01000004_gene4922 7.9e-108 397.9 Bacteria ko:K01992 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 28M0D@1,2ZAFE@2 NA|NA|NA S Putative ATP-binding cassette PFHLONEA_02551 1499967.BAYZ01000152_gene1432 1.3e-83 316.2 unclassified Bacteria ecsA ko:K01990 M00254 ko00000,ko00002,ko02000 3.A.1 Bacteria 2NPDQ@2323,COG1131@1,COG1131@2 NA|NA|NA V ATPases associated with a variety of cellular activities PFHLONEA_02552 96561.Dole_0148 1.6e-64 253.8 Desulfobacterales Bacteria 1RARF@1224,2MJNR@213118,2WN3R@28221,42R14@68525,COG1305@1,COG1305@2 NA|NA|NA E PFAM transglutaminase domain protein PFHLONEA_02553 316067.Geob_2472 1.7e-35 156.0 Deltaproteobacteria 2.1.1.137 ko:K07755 ko00000,ko01000 Bacteria 1PEBD@1224,2WPN7@28221,42T7H@68525,COG0500@1,COG2226@2 NA|NA|NA Q Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PFHLONEA_02554 1294265.JCM21738_1194 3e-34 152.1 Bacilli Bacteria 1VP9M@1239,2CRK8@1,32SP8@2,4HR71@91061 NA|NA|NA S Domain of unknown function (DUF4253) PFHLONEA_02557 13689.BV96_04686 3.4e-16 91.3 Sphingomonadales Bacteria 1PDV9@1224,2KASQ@204457,2V0U3@28211,COG0840@1,COG0840@2 NA|NA|NA NT transmembrane signaling receptor activity PFHLONEA_02558 330214.NIDE3962 1.3e-49 203.0 Nitrospirae Bacteria 3J16E@40117,COG0705@1,COG0705@2 NA|NA|NA S Rhomboid family PFHLONEA_02559 316067.Geob_2164 1.5e-51 210.3 Desulfuromonadales Bacteria 1NV0N@1224,2WUW0@28221,42ZH3@68525,43UQG@69541,COG0745@1,COG0745@2 NA|NA|NA T zinc-ribbon domain PFHLONEA_02562 909663.KI867149_gene3401 1.6e-84 319.3 Syntrophobacterales nodJ ko:K09694 ko02010,map02010 M00252 ko00000,ko00001,ko00002,ko02000 3.A.1.102 Bacteria 1N55T@1224,2MQHF@213462,2WK3B@28221,42N8F@68525,COG0842@1,COG0842@2 NA|NA|NA V ABC-2 type transporter PFHLONEA_02563 909663.KI867149_gene3402 1.5e-62 245.7 Syntrophobacterales nodI ko:K01990,ko:K09695 ko02010,map02010 M00252,M00254 ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.102 Bacteria 1MUX3@1224,2MQFC@213462,2WM7T@28221,42MV1@68525,COG1131@1,COG1131@2 NA|NA|NA V AAA domain, putative AbiEii toxin, Type IV TA system PFHLONEA_02565 1101195.Meth11DRAFT_0268 1.1e-30 139.4 Bacteria 3.1.26.11 ko:K00784 ko03013,map03013 ko00000,ko00001,ko01000,ko03016 Bacteria COG5646@1,COG5646@2 NA|NA|NA S Domain of unknown function (DU1801) PFHLONEA_02567 330214.NIDE3365 3.1e-73 283.1 Nitrospirae ko:K01999 ko02010,ko02024,map02010,map02024 M00237 ko00000,ko00001,ko00002,ko02000 3.A.1.4 Bacteria 3J18U@40117,COG0683@1,COG0683@2 NA|NA|NA E Periplasmic binding protein PFHLONEA_02568 1123376.AUIU01000011_gene879 1.3e-50 206.5 Nitrospirae ywhC ko:K06402 ko00000,ko01000,ko01002 Bacteria 3J14Q@40117,COG1994@1,COG1994@2 NA|NA|NA S Peptidase family M50 PFHLONEA_02569 671143.DAMO_2847 1.5e-119 436.0 unclassified Bacteria trpS GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 2NNQX@2323,COG0180@1,COG0180@2 NA|NA|NA J tRNA synthetases class I (W and Y) PFHLONEA_02570 335543.Sfum_1586 7.1e-77 294.3 Syntrophobacterales ispB GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663 2.5.1.30,2.5.1.90 ko:K00805,ko:K02523 ko00900,ko01110,map00900,map01110 R09247,R09248 RC00279 ko00000,ko00001,ko01000,ko01006 iYL1228.KPN_03597,ic_1306.c3945 Bacteria 1MUK6@1224,2MQBX@213462,2WK2M@28221,42M1B@68525,COG0142@1,COG0142@2 NA|NA|NA H Belongs to the FPP GGPP synthase family PFHLONEA_02571 289376.THEYE_A1293 1.4e-44 186.0 Bacteria amrA ko:K06990,ko:K09141 ko00000,ko04812 Bacteria COG2078@1,COG2078@2 NA|NA|NA S ferrous iron binding PFHLONEA_02573 1232410.KI421426_gene1360 4.7e-122 444.5 Desulfuromonadales Bacteria 1R443@1224,2X238@28221,43A2V@68525,43VF8@69541,COG0845@1,COG0845@2 NA|NA|NA M Biotin-lipoyl like PFHLONEA_02575 289376.THEYE_A1150 4.6e-154 550.8 Nitrospirae gatA 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 Bacteria 3J0AA@40117,COG0154@1,COG0154@2 NA|NA|NA J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) PFHLONEA_02576 316067.Geob_2325 4.2e-42 177.9 Desulfuromonadales ruvC GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 ko:K01159 ko03440,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 1MUJI@1224,2WNF9@28221,42QPX@68525,43US0@69541,COG0817@1,COG0817@2 NA|NA|NA L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group PFHLONEA_02577 269799.Gmet_0743 6.1e-89 334.0 Desulfuromonadales yebC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 Bacteria 1MW3X@1224,2WJ1I@28221,42N7Q@68525,43T68@69541,COG0217@1,COG0217@2 NA|NA|NA K regulation of RNA biosynthetic process PFHLONEA_02578 330214.NIDE2978 6e-87 327.8 Nitrospirae yacL GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 Bacteria 3J0G5@40117,COG4956@1,COG4956@2 NA|NA|NA S Large family of predicted nucleotide-binding domains PFHLONEA_02579 330214.NIDE2979 9.1e-132 477.2 Nitrospirae htrA GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 Bacteria 3J0X9@40117,COG0265@1,COG0265@2 NA|NA|NA M Evidence 2a Function of homologous gene experimentally demonstrated in an other organism PFHLONEA_02580 1121422.AUMW01000023_gene2748 5.9e-170 604.0 Peptococcaceae bioA 2.6.1.105,2.6.1.62 ko:K00833,ko:K19563 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03231,R10699 RC00006,RC00062,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 iSB619.SA_RS12705 Bacteria 1TP9N@1239,25E7B@186801,260CN@186807,COG0161@1,COG0161@2 NA|NA|NA H Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor PFHLONEA_02581 754476.Q7A_940 1.1e-61 244.2 Gammaproteobacteria Bacteria 1QUPY@1224,1RMJV@1236,COG4262@1,COG4262@2 NA|NA|NA S Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine PFHLONEA_02584 909663.KI867150_gene2631 1.3e-72 279.6 Syntrophobacterales pcm 2.1.1.77 ko:K00573 ko00000,ko01000 Bacteria 1MXQC@1224,2MRM3@213462,2WMZI@28221,42QXM@68525,COG2518@1,COG2518@2 NA|NA|NA O Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins PFHLONEA_02585 309801.trd_A0056 9.5e-48 196.8 Thermomicrobia 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 R00519 RC02796 ko00000,ko00001,ko01000 Bacteria 27Z11@189775,2G62W@200795,COG0243@1,COG0243@2 NA|NA|NA C Molybdopterin oxidoreductase Fe4S4 domain PFHLONEA_02586 1128421.JAGA01000002_gene1536 0.0 1085.5 unclassified Bacteria fdhA2 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 R00519 RC02796 ko00000,ko00001,ko01000 Bacteria 2NQFR@2323,COG0243@1,COG0243@2 NA|NA|NA C Molydopterin dinucleotide binding domain PFHLONEA_02587 986075.CathTA2_1826 2.3e-76 292.4 Bacilli ko:K00124 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 R00519 RC02796 ko00000,ko00001 Bacteria 1TT2G@1239,4HII4@91061,COG0437@1,COG0437@2 NA|NA|NA C 4Fe-4S ferredoxin PFHLONEA_02588 479434.Sthe_3390 4.2e-47 195.3 Thermomicrobia Bacteria 27YBQ@189775,2GA0G@200795,COG3301@1,COG3301@2 NA|NA|NA P Polysulphide reductase, NrfD PFHLONEA_02589 1005048.CFU_1840 1.9e-113 415.6 Oxalobacteraceae Bacteria 1MUQJ@1224,2VJNP@28216,475EI@75682,COG1409@1,COG1409@2 NA|NA|NA S Calcineurin-like phosphoesterase superfamily domain PFHLONEA_02590 1005048.CFU_1839 7.2e-22 110.2 Oxalobacteraceae 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 Bacteria 1NEC9@1224,2VWA0@28216,477JR@75682,COG1622@1,COG1622@2 NA|NA|NA C Cupredoxin-like domain PFHLONEA_02591 1128421.JAGA01000002_gene1531 7.7e-31 141.4 unclassified Bacteria fdhE ko:K02380 ko00000 Bacteria 2NRGD@2323,COG3058@1,COG3058@2 NA|NA|NA O Protein involved in formate dehydrogenase formation PFHLONEA_02592 909663.KI867150_gene2912 5e-40 171.0 Syntrophobacterales Bacteria 1N3AR@1224,2MQIV@213462,2WQEC@28221,42UWM@68525,COG3945@1,COG3945@2 NA|NA|NA S PFAM Hemerythrin HHE cation binding domain PFHLONEA_02593 1265505.ATUG01000001_gene3625 5.4e-77 294.3 Desulfobacterales Bacteria 1MU3A@1224,2MPTJ@213118,2WNPE@28221,42S73@68525,COG0745@1,COG0745@2 NA|NA|NA T Transcriptional regulatory protein, C terminal PFHLONEA_02598 330214.NIDE4329 2.8e-23 115.2 Nitrospirae murJ ko:K03980 ko00000,ko01011,ko02000 2.A.66.4 Bacteria 3J0CQ@40117,COG0728@1,COG0728@2 NA|NA|NA S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane PFHLONEA_02599 1157490.EL26_00450 1.9e-18 99.0 Alicyclobacillaceae ogt 2.1.1.63,3.2.2.21 ko:K00567,ko:K13529,ko:K13531 ko03410,map03410 ko00000,ko00001,ko01000,ko03000,ko03400 Bacteria 1VA03@1239,27A5E@186823,4HJRJ@91061,COG0350@1,COG0350@2 NA|NA|NA L 6-O-methylguanine DNA methyltransferase, DNA binding domain PFHLONEA_02600 1121405.dsmv_1596 2.6e-64 251.9 Desulfobacterales ycbL GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019243,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0051596,GO:0061727,GO:0071704,GO:1901575,GO:1901615 3.1.2.6 ko:K01069 ko00620,map00620 R01736 RC00004,RC00137 ko00000,ko00001,ko01000 Bacteria 1MUDN@1224,2MJKK@213118,2WN14@28221,42QWD@68525,COG0491@1,COG0491@2 NA|NA|NA S Metallo-beta-lactamase superfamily PFHLONEA_02601 555079.Toce_2133 2e-207 728.8 Thermoanaerobacterales nrdZ 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 Bacteria 1TPFH@1239,249EN@186801,42F6G@68295,COG0209@1,COG0209@2 NA|NA|NA F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen PFHLONEA_02603 420324.KI912074_gene5946 1.3e-119 436.8 Methylobacteriaceae nuoN GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 1JR8M@119045,1MV56@1224,2TQMX@28211,COG1007@1,COG1007@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient PFHLONEA_02604 330214.NIDE0603 5.8e-158 564.3 Nitrospirae nuoM 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 3J0EQ@40117,COG1008@1,COG1008@2 NA|NA|NA C Evidence 2a Function of homologous gene experimentally demonstrated in an other organism PFHLONEA_02605 706587.Desti_2759 1.2e-107 396.7 Syntrophobacterales nuoL-1 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 Bacteria 1MW2M@1224,2MS08@213462,2WIPT@28221,42KZE@68525,COG1009@1,COG1009@2 NA|NA|NA CP NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus PFHLONEA_02606 443143.GM18_1123 3.8e-153 548.1 Desulfuromonadales cimA 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 Bacteria 1MUNQ@1224,2WJC9@28221,42MAV@68525,43TBU@69541,COG0119@1,COG0119@2 NA|NA|NA E Belongs to the alpha-IPM synthase homocitrate synthase family PFHLONEA_02607 338963.Pcar_1825 7e-13 80.5 Desulfuromonadales rseC GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0016020,GO:0044464,GO:0050896,GO:0071944 ko:K03803 ko00000,ko03021 Bacteria 1PKXC@1224,2WPMZ@28221,42UU9@68525,43SP6@69541,COG3086@1,COG3086@2 NA|NA|NA T Positive regulator of sigma(E), RseC/MucC PFHLONEA_02608 1232410.KI421412_gene329 5.5e-20 103.6 Desulfuromonadales Bacteria 1N0FP@1224,2CDR8@1,2WR2G@28221,32XIQ@2,42TMS@68525,43SN9@69541 NA|NA|NA PFHLONEA_02609 1123376.AUIU01000016_gene292 4.6e-230 804.3 Nitrospirae fusA-1 ko:K02355 ko00000,ko03012,ko03029 Bacteria 3J0WU@40117,COG0480@1,COG0480@2 NA|NA|NA J Elongation factor G, domain IV PFHLONEA_02610 335543.Sfum_0520 5.7e-88 330.9 Syntrophobacterales kynB 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 Bacteria 1P8U5@1224,2MSBX@213462,2WPQ7@28221,42SY1@68525,COG1878@1,COG1878@2 NA|NA|NA S Putative cyclase PFHLONEA_02611 266117.Rxyl_2819 1.3e-31 143.3 Bacteria Bacteria COG2345@1,COG2345@2 NA|NA|NA K Transcriptional regulator PFHLONEA_02612 1391646.AVSU01000016_gene3190 3.8e-58 231.5 Clostridia M1-670 Bacteria 1V5F7@1239,25BMI@186801,COG1388@1,COG1388@2 NA|NA|NA M LysM domain PFHLONEA_02614 1278073.MYSTI_02032 3.5e-46 191.4 Bacteria tmk GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 iLJ478.TM1099 Bacteria COG0125@1,COG0125@2 NA|NA|NA F dTDP biosynthetic process PFHLONEA_02615 269799.Gmet_1703 2.4e-57 229.9 Bacteria Bacteria COG2010@1,COG2010@2 NA|NA|NA C Cytochrome c PFHLONEA_02616 1123376.AUIU01000013_gene1827 8.9e-17 92.8 Bacteria yhcC GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464,GO:0048037,GO:0051536,GO:0051539,GO:0051540 ko:K07139 ko00000 Bacteria COG1242@1,COG1242@2 NA|NA|NA K 4 iron, 4 sulfur cluster binding PFHLONEA_02617 1232410.KI421424_gene1681 1.6e-64 252.7 Desulfuromonadales Bacteria 1R9W5@1224,2WMV0@28221,42QNF@68525,43SGE@69541,COG1387@1,COG1387@2 NA|NA|NA E DNA polymerase alpha chain like domain PFHLONEA_02620 316067.Geob_0755 9.7e-93 347.4 Desulfuromonadales CP_0155 ko:K08307,ko:K12204 ko00000,ko01000,ko01011,ko02044 3.A.7.10.1,3.A.7.9.1 Bacteria 1MWKE@1224,2WJ54@28221,42M5C@68525,43U1B@69541,COG0741@1,COG0741@2,COG1388@1,COG1388@2 NA|NA|NA M Lytic transglycosylase, SLT, LysM and LysM domain-containing PFHLONEA_02621 243231.GSU1721 3e-43 182.2 Desulfuromonadales queE 1.97.1.4,4.3.99.3 ko:K04068,ko:K10026 ko00790,ko01100,map00790,map01100 R04710,R10002 RC02989 ko00000,ko00001,ko01000,ko03016 iAF987.Gmet_1658 Bacteria 1MUJ2@1224,2WNJ0@28221,42RT9@68525,43SFA@69541,COG0602@1,COG0602@2 NA|NA|NA H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds PFHLONEA_02622 1121472.AQWN01000003_gene1415 9e-60 238.0 Peptococcaceae FbpA ko:K12341 ko03070,map03070 ko00000,ko00001,ko02044 1.B.40.1.1 Bacteria 1TQ8A@1239,248RK@186801,2615B@186807,COG1293@1,COG1293@2 NA|NA|NA K Fibronectin-binding protein A N-terminus (FbpA) PFHLONEA_02623 1232410.KI421413_gene612 8.5e-17 93.6 Bacteria ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 ko00000,ko00001,ko03000 Bacteria COG0664@1,COG0664@2 NA|NA|NA T cyclic nucleotide binding PFHLONEA_02624 330214.NIDE1410 4.4e-55 221.9 Nitrospirae aroB 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 R03409 RC00002 ko00000,ko00001,ko01000 Bacteria 3J0K5@40117,COG0248@1,COG0248@2 NA|NA|NA FP Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology PFHLONEA_02625 56780.SYN_01093 1.1e-136 493.4 Syntrophobacterales ko:K02481,ko:K07713,ko:K07714 ko02020,map02020 M00499,M00500 ko00000,ko00001,ko00002,ko02022 Bacteria 1MU0N@1224,2MRFN@213462,2WIT0@28221,42M03@68525,COG2204@1,COG2204@2 NA|NA|NA T Bacterial regulatory protein, Fis family PFHLONEA_02627 671143.DAMO_1803 1.8e-26 125.6 Bacteria Bacteria 2EAWU@1,334Y1@2 NA|NA|NA S Hemerythrin HHE cation binding domain PFHLONEA_02628 868131.MSWAN_1119 7.2e-129 467.2 Archaea Archaea arCOG11926@1,arCOG11926@2157 NA|NA|NA PFHLONEA_02632 1121920.AUAU01000017_gene1231 1.8e-47 195.3 Bacteria Z012_09115 ko:K15977 ko00000 Bacteria COG2259@1,COG2259@2 NA|NA|NA S methylamine metabolic process PFHLONEA_02633 316067.Geob_1840 7.3e-58 230.7 Desulfuromonadales Bacteria 1MU7F@1224,2X6WN@28221,43BI9@68525,43U6T@69541,COG1801@1,COG1801@2 NA|NA|NA S Protein of unknown function DUF72 PFHLONEA_02634 316067.Geob_0336 2.6e-153 548.9 Desulfuromonadales ligD 6.5.1.1 ko:K01971 ko03450,map03450 R00381 RC00005 ko00000,ko00001,ko01000,ko03400 Bacteria 1MVWY@1224,2X2C1@28221,4378Y@68525,43UD2@69541,COG1793@1,COG1793@2,COG3285@1,COG3285@2 NA|NA|NA L ATP dependent DNA ligase C terminal region PFHLONEA_02635 706587.Desti_0133 4.5e-78 298.1 Deltaproteobacteria ligD GO:0000166,GO:0000287,GO:0000726,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0003896,GO:0003899,GO:0003909,GO:0003910,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0004652,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006269,GO:0006281,GO:0006302,GO:0006303,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016874,GO:0016886,GO:0016895,GO:0017076,GO:0018130,GO:0019438,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0033554,GO:0034061,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0070566,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0097747,GO:0140097,GO:0140098,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 ko:K01971,ko:K10747 ko03030,ko03410,ko03420,ko03430,ko03450,map03030,map03410,map03420,map03430,map03450 R00381,R00382,R10822,R10823 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 Bacteria 1MVWY@1224,2WU2C@28221,42Z1A@68525,COG3285@1,COG3285@2 NA|NA|NA L DNA polymerase LigD polymerase domain PFHLONEA_02636 706587.Desti_2360 5e-49 201.4 Deltaproteobacteria ku GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0097159,GO:1901363 ko:K10979 ko03450,map03450 ko00000,ko00001,ko03400 Bacteria 1N4UX@1224,2WMZ1@28221,42RD5@68525,COG1273@1,COG1273@2 NA|NA|NA L With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD PFHLONEA_02637 404589.Anae109_1008 1e-38 167.2 Myxococcales ku GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0097159,GO:1901363 ko:K10979 ko03450,map03450 ko00000,ko00001,ko03400 Bacteria 1N4UX@1224,2WMZ1@28221,2YV5B@29,42RD5@68525,COG1273@1,COG1273@2 NA|NA|NA L With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD PFHLONEA_02638 667632.KB890182_gene876 2.6e-26 125.2 Burkholderiaceae 3.5.1.56 ko:K03418 ko00630,map00630 R02509 RC00111,RC00731 ko00000,ko00001,ko01000 Bacteria 1K4V0@119060,1NDU1@1224,2WBCG@28216,COG1520@1,COG1520@2 NA|NA|NA S Pyrrolo-quinoline quinone PFHLONEA_02639 1232410.KI421426_gene1469 1.1e-27 130.6 Desulfuromonadales Bacteria 1MZYK@1224,2WR6C@28221,32Y28@2,42TR5@68525,43UQM@69541,COG1226@1 NA|NA|NA P Ion channel PFHLONEA_02641 1210884.HG799475_gene15269 3.6e-230 804.3 Planctomycetes pgm GO:0000271,GO:0003674,GO:0003824,GO:0004614,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0005996,GO:0006006,GO:0006012,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0016868,GO:0019318,GO:0019320,GO:0019388,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0055114,GO:0071704,GO:1901575,GO:1901576 5.4.2.2 ko:K01835 ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00549 R00959,R01057,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 iAPECO1_1312.APECO1_1376,iECED1_1282.ECED1_0670,iECNA114_1301.ECNA114_0627,iECOK1_1307.ECOK1_0699,iECP_1309.ECP_0709,iECS88_1305.ECS88_0725,iJN678.pgm,iLF82_1304.LF82_1632,iNRG857_1313.NRG857_03110,iUMN146_1321.UM146_14115,iYL1228.KPN_00711 Bacteria 2IYG0@203682,COG0033@1,COG0033@2 NA|NA|NA G Phosphoglucomutase/phosphomannomutase, C-terminal domain PFHLONEA_02642 706587.Desti_0534 3.4e-15 87.4 Syntrophobacterales pyk 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 Bacteria 1MU21@1224,2MQT1@213462,2WJSW@28221,42N30@68525,COG0469@1,COG0469@2 NA|NA|NA G Belongs to the pyruvate kinase family PFHLONEA_02643 269799.Gmet_1653 3e-112 411.4 Deltaproteobacteria gpmA GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031 5.4.2.11 ko:K01834 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 Bacteria 1MUVE@1224,2WKJN@28221,42PJM@68525,COG0588@1,COG0588@2 NA|NA|NA G Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily PFHLONEA_02645 255470.cbdbA1606 4.1e-08 63.9 Dehalococcoidia Bacteria 2G9EC@200795,34DEF@301297,COG2862@1,COG2862@2 NA|NA|NA S Uncharacterized protein family, UPF0114 PFHLONEA_02646 56780.SYN_01009 8.2e-301 1039.6 Syntrophobacterales 3.6.3.8 ko:K01537 ko00000,ko01000 3.A.3.2 Bacteria 1MUU5@1224,2MR2C@213462,2WIU0@28221,42M8F@68525,COG0474@1,COG0474@2 NA|NA|NA P Cation transporter/ATPase, N-terminus PFHLONEA_02652 316057.RPD_0208 1.6e-44 185.7 Bradyrhizobiaceae dut GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 Bacteria 1RA7P@1224,2U7B5@28211,3JYQC@41294,COG0756@1,COG0756@2 NA|NA|NA F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA PFHLONEA_02653 138119.DSY2506 2.3e-69 269.2 Peptococcaceae pepR GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 Bacteria 1TP5I@1239,248HT@186801,260B8@186807,COG0612@1,COG0612@2 NA|NA|NA S Belongs to the peptidase M16 family PFHLONEA_02654 1121405.dsmv_1158 1.3e-65 256.1 Deltaproteobacteria 5.2.1.8 ko:K03767,ko:K03768 ko01503,ko04217,map01503,map04217 ko00000,ko00001,ko01000,ko03110,ko04147 Bacteria 1R4KH@1224,2WWSG@28221,42R08@68525,COG0652@1,COG0652@2 NA|NA|NA O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides PFHLONEA_02657 1449126.JQKL01000012_gene3508 1.4e-123 450.3 unclassified Clostridiales recJ 3.6.4.12 ko:K03654,ko:K06877,ko:K07462 ko03018,ko03410,ko03430,ko03440,map03018,map03410,map03430,map03440 ko00000,ko00001,ko01000,ko03400 Bacteria 1TPXE@1239,247NU@186801,267Q1@186813,COG0514@1,COG0514@2,COG0608@1,COG0608@2 NA|NA|NA L DHH family PFHLONEA_02658 1123371.ATXH01000013_gene1507 2.4e-10 70.9 Thermodesulfobacteria tatA ko:K03116 ko03060,ko03070,map03060,map03070 M00336 ko00000,ko00001,ko00002,ko02044 2.A.64 Bacteria 2GIP7@200940,COG1826@1,COG1826@2 NA|NA|NA U mttA/Hcf106 family PFHLONEA_02659 264732.Moth_2174 5.7e-37 161.0 Thermoanaerobacterales mobA 2.7.7.77 ko:K03752,ko:K13818 ko00790,ko01100,map00790,map01100 R11581 ko00000,ko00001,ko01000 Bacteria 1VA6T@1239,24JG6@186801,42GTS@68295,COG0746@1,COG0746@2 NA|NA|NA H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor PFHLONEA_02662 118173.KB235914_gene4043 2.8e-24 119.0 Oscillatoriales Bacteria 1G2X4@1117,1HA68@1150,COG4221@1,COG4221@2 NA|NA|NA S Belongs to the short-chain dehydrogenases reductases (SDR) family PFHLONEA_02663 1408473.JHXO01000006_gene1373 6.4e-42 177.2 Bacteroidia paiA Bacteria 2FPFH@200643,4NQVT@976,COG0454@1,COG0456@2 NA|NA|NA K Psort location Cytoplasmic, score 8.96 PFHLONEA_02664 635013.TherJR_0831 5.6e-52 210.7 Peptococcaceae purD 6.3.2.6,6.3.4.13,6.3.5.3 ko:K01945,ko:K01952,ko:K13713 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144,R04463,R04591 RC00010,RC00064,RC00090,RC00162,RC00166,RC01160 ko00000,ko00001,ko00002,ko01000 iSB619.SA_RS05245,iYO844.BSU06530 Bacteria 1UHN9@1239,25E76@186801,2609N@186807,COG0151@1,COG0151@2 NA|NA|NA F Belongs to the GARS family PFHLONEA_02665 706587.Desti_1130 5.2e-49 201.1 Syntrophobacterales purE 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 Bacteria 1RCWJ@1224,2MRQB@213462,2WPG2@28221,42QTK@68525,COG0041@1,COG0041@2 NA|NA|NA F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) PFHLONEA_02666 765913.ThidrDRAFT_2504 1.3e-53 216.9 Chromatiales 2.7.1.33 ko:K09116,ko:K09680 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 Bacteria 1RI11@1224,1S1DR@1236,1WWIA@135613,COG1578@1,COG1578@2 NA|NA|NA S Protein of unknown function DUF89 PFHLONEA_02667 1131269.AQVV01000001_gene1325 7.6e-40 170.6 Bacteria prmC 2.7.7.87 ko:K07566 R10463 RC00745 ko00000,ko01000,ko03009,ko03016 Bacteria COG0009@1,COG0009@2 NA|NA|NA J L-threonylcarbamoyladenylate synthase PFHLONEA_02668 1232410.KI421418_gene2369 2.7e-148 531.9 Desulfuromonadales phoH ko:K07175 ko00000 Bacteria 1MUX1@1224,2WJ1C@28221,42MK9@68525,43SAB@69541,COG1875@1,COG1875@2 NA|NA|NA T Large family of predicted nucleotide-binding domains PFHLONEA_02669 565033.GACE_0099 5.1e-22 112.1 Archaeoglobi Archaea 246R3@183980,2Y31C@28890,arCOG06549@1,arCOG06549@2157 NA|NA|NA C NapC/NirT cytochrome c family, N-terminal region PFHLONEA_02670 330214.NIDE1676 3.9e-34 151.0 Nitrospirae radA ko:K04485 ko00000,ko03400 Bacteria 3J0BP@40117,COG1066@1,COG1066@2 NA|NA|NA O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function PFHLONEA_02671 247490.KSU1_C1150 7.1e-127 460.7 Planctomycetes acrA ko:K02005 ko00000 Bacteria 2IYR9@203682,COG0845@1,COG0845@2 NA|NA|NA M Barrel-sandwich domain of CusB or HlyD membrane-fusion PFHLONEA_02674 926561.KB900617_gene1766 2.1e-68 266.5 Halanaerobiales tlyC ko:K03699,ko:K06189 ko00000,ko02000,ko02042 9.A.40.1.2 Bacteria 1TPN0@1239,2489N@186801,3WAE6@53433,COG1253@1,COG1253@2 NA|NA|NA S CBS domain PFHLONEA_02677 671143.DAMO_2469 9.1e-205 719.9 unclassified Bacteria proS 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 2NNNH@2323,COG0442@1,COG0442@2 NA|NA|NA J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS PFHLONEA_02678 269799.Gmet_1353 8.8e-137 493.4 Desulfuromonadales ispG GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009055,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0022900,GO:0030312,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044464,GO:0046429,GO:0046490,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0052592,GO:0055114,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 iHN637.CLJU_RS06430,iJN678.gcpE Bacteria 1MUAX@1224,2WJJ4@28221,42M3V@68525,43T8H@69541,COG0821@1,COG0821@2 NA|NA|NA I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate PFHLONEA_02679 1499967.BAYZ01000078_gene992 3.8e-94 352.1 unclassified Bacteria rseP ko:K11749 ko02024,ko04112,map02024,map04112 ko00000,ko00001,ko01000,ko01002 Bacteria 2NP7C@2323,COG0750@1,COG0750@2 NA|NA|NA M zinc metalloprotease PFHLONEA_02680 1232410.KI421418_gene2268 4e-116 424.9 Desulfuromonadales dxr GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0050897,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 iAPECO1_1312.APECO1_1814,iECOK1_1307.ECOK1_0174,iECS88_1305.ECS88_0183,iHN637.CLJU_RS06420,iNJ661.Rv2870c,iUMN146_1321.UM146_23670,iUTI89_1310.UTI89_C0188 Bacteria 1MU4G@1224,2WK14@28221,42NI1@68525,43SBW@69541,COG0743@1,COG0743@2 NA|NA|NA I 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal PFHLONEA_02681 1304888.ATWF01000002_gene415 5.3e-44 184.9 Deferribacteres cdsA 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 Bacteria 2GEMH@200930,COG4589@1,COG4589@2 NA|NA|NA S Cytidylyltransferase family PFHLONEA_02682 289376.THEYE_A0228 1.1e-29 136.0 Nitrospirae uppS GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 iLJ478.TM1398 Bacteria 3J0HJ@40117,COG0020@1,COG0020@2 NA|NA|NA H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids PFHLONEA_02683 330214.NIDE2040 7.1e-52 209.9 Nitrospirae trpE 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0FG@40117,COG0147@1,COG0147@2 NA|NA|NA EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia PFHLONEA_02684 635013.TherJR_1606 3.7e-78 297.7 Peptococcaceae pabA GO:0000162,GO:0003674,GO:0003824,GO:0004049,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006575,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009108,GO:0009308,GO:0009309,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042398,GO:0042401,GO:0042430,GO:0042435,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046820,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 2.6.1.85,4.1.3.27 ko:K01658,ko:K01664 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716 RC00010,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 iYO844.BSU00750 Bacteria 1TT9R@1239,24FR0@186801,261J7@186807,COG0512@1,COG0512@2 NA|NA|NA EH TIGRFAM glutamine amidotransferase of anthranilate synthase PFHLONEA_02685 330214.NIDE2042 3.4e-106 391.7 Nitrospirae trpD GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 ko:K00766,ko:K13497 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R00985,R00986,R01073 RC00010,RC00440,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2495 Bacteria 3J0HE@40117,COG0547@1,COG0547@2 NA|NA|NA E Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) PFHLONEA_02686 1232410.KI421415_gene3077 1.3e-70 273.1 Desulfuromonadales trpC GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831 4.1.1.48,5.3.1.24 ko:K01609,ko:K13498 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508,R03509 RC00944,RC00945 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_2494,iJN746.PP_0422 Bacteria 1MW5K@1224,2WM94@28221,42MAG@68525,43S5I@69541,COG0134@1,COG0134@2 NA|NA|NA E Belongs to the TrpC family PFHLONEA_02687 289376.THEYE_A0943 5.2e-57 227.6 Nitrospirae trpF 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0SA@40117,COG0135@1,COG0135@2 NA|NA|NA E N-(5'phosphoribosyl)anthranilate (PRA) isomerase PFHLONEA_02688 330214.NIDE2046 1.3e-165 589.3 Nitrospirae trpB 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0E1@40117,COG0133@1,COG0133@2 NA|NA|NA E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine PFHLONEA_02691 1232410.KI421412_gene383 2.9e-63 248.4 Desulfuromonadales Bacteria 1RECN@1224,2WNXD@28221,43DS9@68525,43TGM@69541,COG0778@1,COG0778@2 NA|NA|NA C Nitroreductase family PFHLONEA_02693 686340.Metal_1264 1.7e-24 120.6 Methylococcales Bacteria 1QIY7@1224,1TGUU@1236,1XGRI@135618,2AVBQ@1,31M30@2 NA|NA|NA PFHLONEA_02694 525897.Dbac_3408 2.2e-102 379.0 Desulfovibrionales trxB 1.8.1.9 ko:K00384 ko00450,map00450 R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 Bacteria 1MV15@1224,2M86G@213115,2WIY8@28221,42MHR@68525,COG0492@1,COG0492@2 NA|NA|NA C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family PFHLONEA_02698 1123376.AUIU01000019_gene1247 3.1e-177 629.0 Nitrospirae mrcA GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 ko00000,ko00001,ko01000,ko01003,ko01011 GT51 iAF987.Gmet_0354 Bacteria 3J0BH@40117,COG5009@1,COG5009@2 NA|NA|NA M Penicillin-binding protein OB-like domain PFHLONEA_02700 857087.Metme_3902 5e-51 207.2 Methylococcales ko:K02485 ko00000,ko02022 Bacteria 1QUN7@1224,1T3Z8@1236,1XGIJ@135618,COG0784@1,COG0784@2 NA|NA|NA T SMART Signal transduction response regulator, receiver region PFHLONEA_02701 562970.Btus_2812 2.6e-22 111.3 Alicyclobacillaceae prfB GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 ko:K02836 ko00000,ko03012 Bacteria 1TPSB@1239,2797I@186823,4H9N2@91061,COG1186@1,COG1186@2 NA|NA|NA J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA PFHLONEA_02702 96561.Dole_1127 1.8e-81 310.5 Desulfobacterales amiC 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 Bacteria 1MUQK@1224,2MHPG@213118,2WJHW@28221,42MPH@68525,COG0860@1,COG0860@2 NA|NA|NA M N-acetylmuramoyl-L-alanine amidase PFHLONEA_02703 1195236.CTER_4632 3.5e-34 151.0 Ruminococcaceae rplT GO:0000027,GO:0000900,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0060255,GO:0065003,GO:0065007,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090079,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2000113,GO:2001141 ko:K02887 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1V6DB@1239,24JBJ@186801,3WIYY@541000,COG0292@1,COG0292@2 NA|NA|NA J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit PFHLONEA_02704 1487953.JMKF01000065_gene4546 8.3e-10 69.3 Oscillatoriales rpmI GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 ko:K02916 ko03010,map03010 M00178 br01610,ko00000,ko00001,ko00002,ko03011 Bacteria 1G8Z8@1117,1HCZF@1150,COG0291@1,COG0291@2 NA|NA|NA J Belongs to the bacterial ribosomal protein bL35 family PFHLONEA_02705 635013.TherJR_1877 4.6e-48 197.6 Peptococcaceae infC GO:0000049,GO:0001731,GO:0002181,GO:0002183,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006417,GO:0006446,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016020,GO:0016043,GO:0019222,GO:0019538,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032268,GO:0032270,GO:0032790,GO:0032984,GO:0032988,GO:0032991,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043254,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045727,GO:0045948,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065003,GO:0065007,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901193,GO:1901195,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:1904688,GO:1904690,GO:1990856,GO:1990904,GO:2000112,GO:2000765,GO:2000767 ko:K02520 ko00000,ko03012,ko03029 Bacteria 1V1RC@1239,24FUS@186801,260V8@186807,COG0290@1,COG0290@2 NA|NA|NA J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins PFHLONEA_02706 671143.DAMO_1865 1.6e-121 442.6 unclassified Bacteria thrS GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 Bacteria 2NNMT@2323,COG0441@1,COG0441@2 NA|NA|NA J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) PFHLONEA_02707 314345.SPV1_05487 5.1e-40 171.4 Proteobacteria Bacteria 1N0N6@1224,COG2982@1,COG2982@2 NA|NA|NA M Protein involved in outer membrane biogenesis PFHLONEA_02708 1499967.BAYZ01000170_gene5485 3.2e-66 258.5 Bacteria lyc ko:K07273 ko00000 Bacteria COG3757@1,COG3757@2 NA|NA|NA M lysozyme activity PFHLONEA_02710 1144275.COCOR_02631 6.8e-53 213.8 Myxococcales nrdR GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 ko:K07738 ko00000,ko03000 Bacteria 1RE7V@1224,2WPK0@28221,2YVAV@29,42SJP@68525,COG1327@1,COG1327@2 NA|NA|NA K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes PFHLONEA_02711 316067.Geob_2673 9.5e-56 223.0 Desulfuromonadales comEB 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 Bacteria 1RD1P@1224,2WNGV@28221,42RHI@68525,43U1G@69541,COG2131@1,COG2131@2 NA|NA|NA F PFAM CMP dCMP deaminase zinc-binding PFHLONEA_02712 1123376.AUIU01000001_gene789 1.6e-158 565.8 Nitrospirae glyA GO:0001505,GO:0003674,GO:0003824,GO:0004372,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006546,GO:0006563,GO:0006565,GO:0006730,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009070,GO:0009071,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016741,GO:0016742,GO:0017144,GO:0019264,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042133,GO:0042135,GO:0042136,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 iG2583_1286.G2583_3081 Bacteria 3J0CB@40117,COG0112@1,COG0112@2 NA|NA|NA E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism PFHLONEA_02713 458233.MCCL_1768 1.1e-45 189.5 Staphylococcaceae rpiB 5.3.1.6 ko:K01808 ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1604 Bacteria 1V3HE@1239,4H19C@90964,4HGXD@91061,COG0698@1,COG0698@2 NA|NA|NA G Ribose/Galactose Isomerase PFHLONEA_02714 290397.Adeh_2106 1.8e-83 315.8 Myxococcales fieF Bacteria 1MUDS@1224,2WM7V@28221,2Z1U0@29,42NCJ@68525,COG0053@1,COG0053@2 NA|NA|NA P Dimerisation domain of Zinc Transporter PFHLONEA_02717 404380.Gbem_0801 4.7e-137 495.4 Deltaproteobacteria Bacteria 1RCM9@1224,2WIU5@28221,42MC4@68525,COG4191@1,COG4191@2 NA|NA|NA T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PFHLONEA_02718 582744.Msip34_2222 4.1e-31 141.7 Proteobacteria 3.6.1.27 ko:K09824,ko:K19302 ko00550,map00550 R05627 RC00002 ko00000,ko00001,ko01000,ko01011 Bacteria 1MZ81@1224,COG0671@1,COG0671@2 NA|NA|NA I PFAM phosphoesterase, PA-phosphatase related PFHLONEA_02721 1499967.BAYZ01000170_gene5496 8.6e-98 364.4 Bacteria Bacteria COG1032@1,COG1032@2 NA|NA|NA C radical SAM domain protein PFHLONEA_02723 211165.AJLN01000097_gene5066 1.7e-147 529.3 Stigonemataceae ampG ko:K08218 ko01501,map01501 M00628 ko00000,ko00001,ko00002,ko02000 2.A.1.25 Bacteria 1G1K4@1117,1JJV3@1189,COG0477@1,COG2814@2 NA|NA|NA EGP Major Facilitator Superfamily PFHLONEA_02724 1458275.AZ34_08280 5.8e-08 63.9 Betaproteobacteria ko:K05807,ko:K06894,ko:K07114,ko:K08309 ko00000,ko01000,ko01011,ko02000 1.A.13.2.2,1.A.13.2.3,1.B.33.1 GH23 Bacteria 1P69R@1224,2W622@28216,COG1729@1,COG1729@2 NA|NA|NA S Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division PFHLONEA_02725 3218.PP1S13_142V6.1 1.8e-17 95.1 Streptophyta GO:0000162,GO:0003674,GO:0003824,GO:0004834,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0006950,GO:0006952,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009605,GO:0009606,GO:0009607,GO:0009617,GO:0009628,GO:0009629,GO:0009630,GO:0009719,GO:0009725,GO:0009735,GO:0009987,GO:0010033,GO:0016043,GO:0016053,GO:0016829,GO:0016830,GO:0016832,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0033036,GO:0033037,GO:0033554,GO:0033984,GO:0034641,GO:0042221,GO:0042401,GO:0042430,GO:0042435,GO:0042545,GO:0042742,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045229,GO:0046219,GO:0046394,GO:0046483,GO:0050896,GO:0051179,GO:0051641,GO:0051704,GO:0051707,GO:0051716,GO:0052386,GO:0052482,GO:0052542,GO:0052543,GO:0052544,GO:0052545,GO:0070727,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0098542,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.2.8,4.2.1.20 ko:K01695,ko:K13222 ko00260,ko00400,ko00402,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map00402,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 Viridiplantae 37QAU@33090,3GCHM@35493,COG0159@1,KOG4175@2759 NA|NA|NA E Belongs to the TrpA family PFHLONEA_02726 316067.Geob_1031 4.9e-146 525.0 Deltaproteobacteria 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 Bacteria 1MV1V@1224,2WIUS@28221,42N5S@68525,COG2114@1,COG2114@2,COG4252@1,COG4252@2 NA|NA|NA T Adenylyl cyclase class-3 4 guanylyl cyclase PFHLONEA_02727 404380.Gbem_1579 1.1e-56 226.9 Deltaproteobacteria 3.1.26.11,3.1.4.17 ko:K00784,ko:K01120 ko00230,ko03013,map00230,map03013 R00191,R01234 RC00296 ko00000,ko00001,ko01000,ko03016 Bacteria 1QU4B@1224,2WPGG@28221,42SHU@68525,COG1234@1,COG1234@2 NA|NA|NA S cAMP phosphodiesterases class-II PFHLONEA_02728 289376.THEYE_A0559 3.6e-93 348.2 Nitrospirae accD 2.1.3.15,6.4.1.2 ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 iJN678.accD Bacteria 3J0CK@40117,COG0777@1,COG0777@2 NA|NA|NA I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA PFHLONEA_02729 1124780.ANNU01000005_gene2377 2.5e-14 84.3 Cytophagia Bacteria 29WP1@1,30I9X@2,47SR6@768503,4NXPZ@976 NA|NA|NA S Protein of unknown function (DUF2905) PFHLONEA_02730 604354.TSIB_0718 1.4e-163 582.8 Thermococci Archaea 245MX@183968,2Y8EH@28890,COG0477@1,arCOG00143@2157 NA|NA|NA G Sugar (and other) transporter PFHLONEA_02731 56780.SYN_02059 1.2e-107 396.4 Syntrophobacterales Bacteria 1QMGX@1224,2MQHV@213462,2WMFN@28221,42PRJ@68525,COG2006@1,COG2006@2 NA|NA|NA S Domain of unknown function (DUF362) PFHLONEA_02732 56780.SYN_02058 3.9e-194 684.5 Syntrophobacterales napG ko:K02572,ko:K02573,ko:K02574,ko:K03616 ko00000 Bacteria 1MY5M@1224,2MSKF@213462,2WJVS@28221,43BPV@68525,COG0348@1,COG0348@2,COG1143@1,COG1143@2,COG1245@1,COG1245@2 NA|NA|NA C 4Fe-4S binding domain PFHLONEA_02734 289376.THEYE_A0954 1.2e-226 792.7 Nitrospirae tkt 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 Bacteria 3J0MM@40117,COG0021@1,COG0021@2 NA|NA|NA G Transketolase, pyrimidine binding domain PFHLONEA_02735 1123368.AUIS01000006_gene667 1.3e-29 136.0 Acidithiobacillales nuoN GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008137,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1902600,GO:1990204 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 iEC042_1314.EC042_2517,iSbBS512_1146.SbBS512_E2652 Bacteria 1MV56@1224,1RPJB@1236,2NCQ0@225057,COG1007@1,COG1007@2 NA|NA|NA C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient PFHLONEA_02736 748449.Halha_1865 3.8e-14 84.3 Clostridia rnhA GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006401,GO:0006725,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016891,GO:0016893,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0032296,GO:0033013,GO:0033014,GO:0034641,GO:0034655,GO:0042364,GO:0042578,GO:0043170,GO:0043755,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046700,GO:0051186,GO:0051188,GO:0071667,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576 3.1.26.4,3.1.3.73 ko:K03469,ko:K06864,ko:K22316 ko00860,ko01100,ko03030,map00860,map01100,map03030 M00122 R04594 RC00017 ko00000,ko00001,ko00002,ko01000,ko03032 Bacteria 1VAJW@1239,24NJ8@186801,COG0328@1,COG0328@2 NA|NA|NA L PFAM ribonuclease H PFHLONEA_02737 290397.Adeh_3940 1.3e-21 110.2 Myxococcales yfcN GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363 Bacteria 1RH34@1224,2WQG8@28221,2YW3V@29,42TQG@68525,COG2840@1,COG2840@2 NA|NA|NA S Smr domain PFHLONEA_02738 247490.KSU1_C0728 3.5e-88 331.6 Planctomycetes mutY ko:K03575 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 2IY33@203682,COG1194@1,COG1194@2 NA|NA|NA L COG1194 A G-specific DNA glycosylase PFHLONEA_02739 289376.THEYE_A0163 3.5e-40 172.2 Bacteria ko:K06871 ko00000 Bacteria COG0641@1,COG0641@2 NA|NA|NA C radical SAM PFHLONEA_02740 1123368.AUIS01000030_gene1253 5.9e-29 133.3 Gammaproteobacteria QU41_18010 2.4.2.18 ko:K00766,ko:K03719 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000,ko03000,ko03036 Bacteria 1NC1H@1224,1SE9N@1236,COG1522@1,COG1522@2 NA|NA|NA K Transcriptional PFHLONEA_02741 1121957.ATVL01000010_gene162 6.5e-13 80.5 Cytophagia Bacteria 47MIE@768503,4NIH4@976,COG1305@1,COG1305@2 NA|NA|NA E Transglutaminase/protease-like homologues PFHLONEA_02742 243164.DET0618 3.8e-10 71.6 Dehalococcoidia Bacteria 2G72F@200795,34DAG@301297,COG0526@1,COG0526@2 NA|NA|NA CO AhpC/TSA family PFHLONEA_02746 330214.NIDE0003 6.6e-294 1016.5 Nitrospirae gyrB GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 ko:K02470 ko00000,ko01000,ko03032,ko03400 Bacteria 3J0BB@40117,COG0187@1,COG0187@2 NA|NA|NA L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner PFHLONEA_02747 330214.NIDE0002 3.9e-103 381.7 Nitrospirae dnaN 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 Bacteria 3J0RU@40117,COG0592@1,COG0592@2 NA|NA|NA L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria PFHLONEA_02748 289376.THEYE_A0015 1.8e-123 449.5 Nitrospirae dnaA GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010556,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:1990837,GO:2000112 ko:K02313 ko02020,ko04112,map02020,map04112 ko00000,ko00001,ko03032,ko03036 Bacteria 3J0FQ@40117,COG0593@1,COG0593@2 NA|NA|NA L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids PFHLONEA_02749 290318.Cvib_0036 1.5e-20 105.1 Chlorobi ko:K04085 ko04122,map04122 ko00000,ko00001,ko01000,ko03016 Bacteria 1FE4M@1090,COG0425@1,COG0425@2 NA|NA|NA O Belongs to the sulfur carrier protein TusA family PFHLONEA_02750 644282.Deba_2661 9.4e-48 196.4 Deltaproteobacteria perX Bacteria 1RDUG@1224,2WRRQ@28221,42VFB@68525,COG2210@1,COG2210@2 NA|NA|NA S DsrE/DsrF/DrsH-like family PFHLONEA_02751 1209989.TepiRe1_0724 5.5e-35 153.7 Thermoanaerobacterales hisE GO:0000105,GO:0000287,GO:0003674,GO:0003824,GO:0004636,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0043167,GO:0043169,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044419,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052803,GO:0071704,GO:0071944,GO:0075136,GO:0075139,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.4.19,3.6.1.31,5.3.1.16 ko:K01496,ko:K01523,ko:K01814,ko:K11755 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035,R04037,R04640 RC00002,RC00945,RC01055 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_1897,iSB619.SA_RS14110,iYO844.BSU34860 Bacteria 1UYNA@1239,247RS@186801,42F6A@68295,COG0139@1,COG0139@2,COG0140@1,COG0140@2 NA|NA|NA E Histidine biosynthesis bifunctional protein hisIE PFHLONEA_02752 289376.THEYE_A0787 4.1e-35 154.1 Nitrospirae hinT ko:K02503 ko00000,ko04147 Bacteria 3J0TA@40117,COG0537@1,COG0537@2 NA|NA|NA FG Scavenger mRNA decapping enzyme C-term binding PFHLONEA_02753 1123507.ATVQ01000003_gene617 8.4e-07 60.1 Bacteria ko:K06039,ko:K07092 ko00000 Bacteria COG2044@1,COG2044@2 NA|NA|NA PFHLONEA_02754 1232410.KI421424_gene1844 4.5e-71 274.2 Desulfuromonadales ko:K07023 ko00000 Bacteria 1R71H@1224,2WKMF@28221,42NGN@68525,43S2K@69541,COG1896@1,COG1896@2 NA|NA|NA S HD domain PFHLONEA_02755 667014.Thein_1367 6.9e-39 167.5 Thermodesulfobacteria adk 2.7.4.3,6.3.4.4 ko:K00939,ko:K01939 ko00230,ko00250,ko00730,ko01100,ko01110,ko01130,map00230,map00250,map00730,map01100,map01110,map01130 M00049 R00127,R01135,R01547,R11319 RC00002,RC00458,RC00459 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2GI9A@200940,COG0563@1,COG0563@2 NA|NA|NA F Adenylate kinase PFHLONEA_02756 1443122.Z958_01730 4.8e-25 120.9 Clostridiaceae rppH_2 3.6.1.55 ko:K03574 ko00000,ko01000,ko03400 Bacteria 1V5NQ@1239,24PPQ@186801,36K3B@31979,COG1051@1,COG1051@2 NA|NA|NA F Belongs to the Nudix hydrolase family PFHLONEA_02757 1536775.H70737_30345 2.9e-08 64.7 Paenibacillaceae rnpA GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031123,GO:0031404,GO:0031974,GO:0031981,GO:0032991,GO:0033204,GO:0034414,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042301,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043168,GO:0043170,GO:0043199,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043628,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901681,GO:1902494,GO:1902555,GO:1905267,GO:1905348,GO:1990904 3.1.26.5 ko:K03536,ko:K08998 ko00000,ko01000,ko03016 Bacteria 1VA78@1239,26XN0@186822,4HKG6@91061,COG0594@1,COG0594@2 NA|NA|NA J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme PFHLONEA_02758 269799.Gmet_3561 3e-75 289.7 Desulfuromonadales yidC GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0031224,GO:0031226,GO:0032940,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051205,GO:0051234,GO:0051259,GO:0051260,GO:0051641,GO:0061024,GO:0065003,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150 ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 Bacteria 1MV5M@1224,2WJB6@28221,42MS8@68525,43T3A@69541,COG0706@1,COG0706@2 NA|NA|NA U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins PFHLONEA_02760 368407.Memar_1765 5.7e-47 193.7 Methanomicrobia mtfK1 5.2.1.8 ko:K01802,ko:K03768,ko:K03775 ko00000,ko01000,ko03110 Archaea 2NAZY@224756,2XXFW@28890,COG1047@1,arCOG00981@2157 NA|NA|NA O peptidyl-prolyl cis-trans isomerase PFHLONEA_02762 289376.THEYE_A1002 2.7e-185 655.6 Nitrospirae Bacteria 3J0AQ@40117,COG1449@1,COG1449@2 NA|NA|NA G Glycosyl hydrolase family 57 PFHLONEA_02763 671143.DAMO_2462 1e-08 66.2 Bacteria divIC ko:K05589,ko:K12065,ko:K13052 ko00000,ko02044,ko03036 3.A.7.11.1 Bacteria COG2919@1,COG2919@2 NA|NA|NA D cell cycle PFHLONEA_02764 671143.DAMO_1184 2.9e-23 115.2 unclassified Bacteria Bacteria 2NRN4@2323,COG1895@1,COG1895@2 NA|NA|NA S HEPN domain PFHLONEA_02765 671143.DAMO_1183 6.6e-43 180.6 Bacteria ko:K07075 ko00000 Bacteria COG1669@1,COG1669@2 NA|NA|NA S nucleotidyltransferase activity PFHLONEA_02766 316067.Geob_1759 2.4e-138 498.8 Desulfuromonadales rhlB GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0019904,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0090304,GO:0097718,GO:0140098,GO:1901360,GO:1901361,GO:1901575 3.6.4.13 ko:K03732 ko03018,map03018 M00394 ko00000,ko00001,ko00002,ko01000,ko03019 Bacteria 1MU49@1224,2WIY6@28221,42MGZ@68525,43TW5@69541,COG0513@1,COG0513@2 NA|NA|NA JKL DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA PFHLONEA_02767 671143.DAMO_2604 1.2e-177 629.8 unclassified Bacteria 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 Bacteria 2NPH9@2323,COG0318@1,COG0318@2 NA|NA|NA IQ COGs COG0318 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II PFHLONEA_02768 1307761.L21SP2_2376 1.2e-116 426.8 Spirochaetes fadA 2.3.1.16,2.3.1.9 ko:K00626,ko:K00632 ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00087,M00088,M00095,M00113,M00373,M00374,M00375 R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000,ko04147 Bacteria 2JBB9@203691,COG0183@1,COG0183@2 NA|NA|NA I Thiolase, C-terminal domain PFHLONEA_02769 745411.B3C1_04925 8.5e-160 570.9 unclassified Gammaproteobacteria fadJ GO:0003674,GO:0003824,GO:0003857,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0008692,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016856,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 iECABU_c1320.ECABU_c26730,iETEC_1333.ETEC_2476,iEcE24377_1341.EcE24377A_2637,ic_1306.c2886 Bacteria 1J5FY@118884,1MU9P@1224,1RMZ8@1236,COG1024@1,COG1024@2,COG1250@1,COG1250@2 NA|NA|NA I 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain PFHLONEA_02770 313624.NSP_4890 1.4e-82 313.2 Nostocales apa2 2.7.7.53 ko:K00988 ko00230,map00230 R00126,R01618 RC00002,RC02753,RC02795 ko00000,ko00001,ko01000 Bacteria 1G2S9@1117,1HIMD@1161,COG4360@1,COG4360@2 NA|NA|NA F PFAM ATP adenylyltransferase PFHLONEA_02773 237368.SCABRO_02049 3.8e-21 107.8 Planctomycetes Bacteria 2J43C@203682,COG3011@1,COG3011@2 NA|NA|NA S Protein of unknown function, DUF393 PFHLONEA_02774 123214.PERMA_0425 5.4e-29 134.4 Aquificae GO:0003674,GO:0003824,GO:0004844,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360 3.2.2.27 ko:K21929 ko03410,map03410 ko00000,ko00001,ko01000,ko03400 Bacteria 2G41P@200783,COG1573@1,COG1573@2 NA|NA|NA L TIGRFAM Phage SPO1 DNA polymerase-related protein PFHLONEA_02776 443143.GM18_3041 4.4e-20 103.6 Bacteria Bacteria COG1051@1,COG1051@2 NA|NA|NA F GDP-mannose mannosyl hydrolase activity PFHLONEA_02777 1232410.KI421421_gene3767 2e-29 134.8 Desulfuromonadales Bacteria 1MVCB@1224,2WMP0@28221,42QPB@68525,43T71@69541,COG0745@1,COG0745@2 NA|NA|NA K response regulator PFHLONEA_02778 1121423.JONT01000006_gene2416 3.7e-09 67.0 Peptococcaceae tatA GO:0008150,GO:0040007 ko:K03116 ko03060,ko03070,map03060,map03070 M00336 ko00000,ko00001,ko00002,ko02044 2.A.64 Bacteria 1TV3X@1239,259BA@186801,2639X@186807,COG1826@1,COG1826@2 NA|NA|NA U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system PFHLONEA_02779 292564.Cyagr_1974 3.3e-48 198.0 Cyanobacteria Bacteria 1G658@1117,COG2323@1,COG2323@2 NA|NA|NA S Protein of unknown function (DUF421) PFHLONEA_02780 1408473.JHXO01000001_gene2324 1.3e-09 70.1 Bacteria Bacteria COG0586@1,COG0586@2 NA|NA|NA S FtsZ-dependent cytokinesis PFHLONEA_02781 1286093.C266_15137 5.4e-81 307.8 Burkholderiaceae uppP 3.6.1.27 ko:K06153 ko00550,map00550 R05627 RC00002 ko00000,ko00001,ko01000,ko01011 Bacteria 1KI4N@119060,1QIA2@1224,2VJDA@28216,COG1968@1,COG1968@2 NA|NA|NA V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP) PFHLONEA_02782 316067.Geob_3763 1.1e-120 440.7 Proteobacteria Bacteria 1QYX0@1224,COG5492@1,COG5492@2 NA|NA|NA N Protein of unknown function (DUF3443) PFHLONEA_02783 269799.Gmet_1675 6e-42 177.2 Proteobacteria Bacteria 1N890@1224,2E5QB@1,330EW@2 NA|NA|NA S Protein of unknown function (DUF2844) PFHLONEA_02784 1370121.AUWS01000082_gene801 8.5e-44 183.3 Mycobacteriaceae 3.1.4.3 ko:K01114 ko00562,ko00564,ko00565,ko01100,ko01110,ko02024,ko04919,map00562,map00564,map00565,map01100,map01110,map02024,map04919 R01312,R02027,R02052,R03332,R07381 RC00017,RC00425 ko00000,ko00001,ko01000,ko02042 Bacteria 2368C@1762,2GKPN@201174,COG3511@1,COG3511@2 NA|NA|NA M virulence factor implicated in the pathogenesis of mycobacterium tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity catalytic activity a phosphatidylcholine H(2)O 1,2- diacylglycerol choline phosphate PFHLONEA_02786 338963.Pcar_0587 2.1e-10 71.6 Desulfuromonadales Bacteria 1NCBW@1224,2EE6A@1,2WSI3@28221,3380W@2,42V9R@68525,43VQV@69541 NA|NA|NA PFHLONEA_02787 289376.THEYE_A0955 3e-154 551.6 Bacteria Bacteria COG3876@1,COG3876@2 NA|NA|NA G Protein conserved in bacteria PFHLONEA_02788 1123373.ATXI01000005_gene900 5.2e-127 461.8 Thermodesulfobacteria hddC GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0006022,GO:0006040,GO:0006082,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017076,GO:0019200,GO:0019752,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046835,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564 2.7.1.221,2.7.7.13,2.7.7.24 ko:K00966,ko:K00973,ko:K07102 ko00051,ko00520,ko00521,ko00523,ko00525,ko01100,ko01110,ko01130,map00051,map00520,map00521,map00523,map00525,map01100,map01110,map01130 M00114,M00361,M00362,M00793 R00885,R02328,R08968,R11024 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 Bacteria 2GHXN@200940,COG1208@1,COG1208@2,COG3178@1,COG3178@2 NA|NA|NA JM Ecdysteroid kinase PFHLONEA_02790 526222.Desal_2901 3e-41 175.3 Deltaproteobacteria ko:K03088 ko00000,ko03021 Bacteria 1PEU8@1224,2WPVH@28221,42T76@68525,COG1595@1,COG1595@2 NA|NA|NA K Belongs to the sigma-70 factor family. ECF subfamily PFHLONEA_02791 243231.GSU2027 1.3e-36 159.1 Desulfuromonadales aroC GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016491,GO:0016651,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 iAF987.Gmet_0976,iNJ661.Rv2540c Bacteria 1MU98@1224,2WJ57@28221,42MF9@68525,43U6V@69541,COG0082@1,COG0082@2 NA|NA|NA E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system PFHLONEA_02792 717231.Flexsi_1828 4.9e-37 161.0 Deferribacteres aroK GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71,4.2.1.10,4.2.3.4 ko:K00891,ko:K03786,ko:K13829 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412,R03083,R03084 RC00002,RC00078,RC00847,RC00848 ko00000,ko00001,ko00002,ko01000 Bacteria 2GFRF@200930,COG0703@1,COG0703@2 NA|NA|NA F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate # 2098 queries scanned # Total time (seconds): 36.9521398544 # Rate: 56.78 q/s