Gene_ID Gene PHI_MolConn_ID Protein.ID Pathogen.ID Identity length mismatch gapopen qstart qend sstart send E_value bitscore Gene.ID Pathogen.species Pathogen.strain Disease Host.description Host.ID Host.species Gene.Function Mutant.Phenotype Exp..Technique.stable Z1_01522 STM14_RS15285 PHI:10070 A0A0F6B5R3 28901 75.8 565 136 1 14 577 5 569 0.0 894.0 ACY89857 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) Formate hydrogenlyase subunit 4 unaffected pathogenicity Gene deletion: full Z1_02447 STM14_RS07770_(ttrA) PHI:10113 A0A0F6B0X7 28901 69.1 1026 311 3 1 1026 1 1020 0.0 1461.0 0 0 0 0 0 0 0 0 0 0 Z1_01736 LptD PHI:10312 P31554 562 59.7 794 298 9 1 785 1 781 0.0 964.0 BAA34130 Escherichia coli KP7600 Urinary tract infection Rodents 10090 Mus musculus (related: house mouse) LPS-assembly protein unaffected pathogenicity Gene mutation Z1_00502 NarG PHI:10512 P09152 562 79.4 1240 253 2 1 1240 1 1238 0.0 2129.0 0 0 0 0 0 0 0 0 0 0 Z1_00501 NarH PHI:10513 P11349 562 84.6 508 76 1 1 506 1 508 0.0 906.0 0 0 0 0 0 0 0 0 0 0 Z1_01265 SpoT PHI:10548 A0A0D6I2I2 28901 84.3 709 104 3 1 708 1 703 0.0 1182.0 0 0 0 0 0 0 0 0 0 0 Z1_02039 Hcp PHI:10593 C6DF39 554 82.4 550 97 0 1 550 1 550 0.0 941.0 0 0 0 0 0 0 0 0 0 0 Z1_03733 ClpB PHI:10595 C6DC70 554 78.9 857 181 0 1 857 1 857 0.0 1304.0 0 0 0 0 0 0 0 0 0 0 Z1_01071 FdoG PHI:10994 P32176 562 83.5 804 132 1 1 803 213 1016 0.0 1432.0 0 0 0 0 0 0 0 0 0 0 Z1_01250 BipA PHI:11030 A0A380PIP1 632 86.4 602 82 0 1 602 1 602 0.0 1041.0 0 0 0 0 0 0 0 0 0 0 Z1_01376 Edd PHI:11150 Q6D652 29471 72.9 601 163 0 16 616 1 601 0.0 892.0 0 0 0 0 0 0 0 0 0 0 Z1_02366 NuoG PHI:11247 Q9I0J6 287 64.2 907 322 2 4 910 1 904 0.0 1155.0 0 0 0 0 0 0 0 0 0 0 Z1_02931 DmsA PHI:11664 P45004 727 75.2 799 195 3 14 811 7 803 0.0 1259.0 0 0 0 0 0 0 0 0 0 0 Z1_00485 FrdA PHI:2960 C5BDL7 67780 87.5 599 74 1 1 598 1 599 0.0 1070.0 0 0 0 0 0 0 0 0 0 0 Z1_02126 GcvP PHI:2961 C5BAT0 67780 70.9 959 277 2 1 957 1 959 0.0 1380.0 0 0 0 0 0 0 0 0 0 0 Z1_03258 RNase_E PHI:3723 E8XEV4 28901 56.0 1178 390 19 1 1166 1 1062 0.0 953.0 0 0 0 0 0 0 0 0 0 0 Z1_00625 Pnp PHI:3878 Q8ZLT3 28901 83.9 700 113 0 1 700 1 700 0.0 1139.0 0 0 0 0 0 0 0 0 0 0 Z1_03375 T6SS2 PHI:4559 Q6TKU1 562 64.4 908 313 5 1 906 1 900 0.0 1097.0 KF678350 Escherichia coli TW-XM Meningitis Birds 8839 Anas platyrhynchos (related: mallard) Type VI secretion systems (T6SSs) effectors effector (plant avirulence determinant) Gene mutation; gene complementation Z1_02051 BcsA PHI:4694 D0ZKI3 28901 54.7 850 365 5 21 857 13 855 0.0 945.0 0 0 0 0 0 0 0 0 0 0 Z1_02558 Ppk PHI:5063 B4EY92 584 99.9 693 1 0 1 693 1 693 0.0 1364.0 0 0 0 0 0 0 0 0 0 0 Z1_02087 SecA PHI:5240 A0A059ZR97 470 58.8 910 363 4 1 901 1 907 0.0 1023.0 0 0 0 0 0 0 0 0 0 0 Z1_01883 HtpG PHI:6472 P0A6Z3 562 81.2 623 114 2 3 623 1 622 0.0 1009.0 0 0 0 0 0 0 0 0 0 0 Z1_01210 FeoB PHI:6941 A0A0F6UGK4 287 67.2 777 243 6 1 776 1 766 0.0 994.0 0 0 0 0 0 0 0 0 0 0 Z1_00306 CpdB PHI:7020 P08331 562 67.9 639 205 0 11 649 9 647 0.0 929.0 0 0 0 0 0 0 0 0 0 0 Z1_00242 Lon PHI:7160 D4HY24 552 89.2 784 85 0 1 784 1 784 0.0 1359.0 0 0 0 0 0 0 0 0 0 0 Z1_00227 AcrB PHI:7307 A0A0H3N916 28901 76.4 1045 243 2 1 1044 1 1042 0.0 1534.0 CBW16569 Salmonella enterica subsp. enterica serovar Typhimurium strain SL1344 Salmonellosis Moths 7137 Galleria mellonella (related: greater wax moth) Efflux pump membrane transporter reduced virulence Gene mutation Z1_00216 YjiY PHI:7575 Q8ZJY5 28901 89.3 717 75 2 1 716 1 716 0.0 1267.0 0 0 0 0 0 0 0 0 0 0 Z1_01346 RpoB PHI:7860 A3M1G3 470 70.7 1363 368 9 1 1338 1 1357 0.0 1871.0 ABO10757 Acinetobacter baumannii ATCC 17978 Nosocomial infection Nematodes 6239 Caenorhabditis elegans (related: roundworm) beta-subunit of the RNA polymerase reduced virulence Gene mutation; gene complementation Z1_03088 ArnA PHI:7951 A6TF98 573 72.7 651 178 0 1 651 1 651 0.0 1013.0 0 0 0 0 0 0 0 0 0 0 Z1_03552 SdhA PHI:7964 P0AC41 562 92.0 588 47 0 1 588 1 588 0.0 1113.0 0 0 0 0 0 0 0 0 0 0 Z1_02391 GyrA PHI:849 Q75WC1 337 62.1 849 313 3 1 840 1 849 0.0 1044.0 BAC98438 Burkholderia glumae M3 Bacterial grain rot Monocots 4530 Oryza sativa (related: rice) DNA gyrase (bacterial topoisomerase II) chemistry target: sensitivity to chemical Gene mutation: characterised Z1_03424 ClpA_(Dda3937_02363) PHI:8569 E0SMW9 204038 80.7 758 135 3 1 755 1 750 0.0 1171.0 0 0 0 0 0 0 0 0 0 0 Z1_02241 PurL_(Dda3937_03379) PHI:8580 E0SB00 204038 75.6 1295 314 2 1 1295 2 1294 0.0 2005.0 0 0 0 0 0 0 0 0 0 0 Z1_02473 FlhA PHI:8731 P40729 28901 76.3 695 161 2 1 694 1 692 0.0 1012.0 0 0 0 0 0 0 0 0 0 0 Z1_03725 YQ_(Yp_0659) PHI:8899 Q8D179 632 69.7 880 267 0 1 880 1 880 0.0 1215.0 0 0 0 0 0 0 0 0 0 0 Z1_00056 SpeC PHI:9151 P21169 562 67.9 719 223 2 1 719 1 711 0.0 1015.0 0 0 0 0 0 0 0 0 0 0 Z1_00152 RelA PHI:9161 Q8Z447 28901 77.3 743 166 1 1 743 1 740 0.0 1180.0 AAO70421 Salmonella enterica subsp. enterica serovar Typhimurium strain SL1344 Salmonellosis Primates 9606 Homo sapiens (related: human) GTP pyrophosphokinase reduced virulence Gene deletion: full; gene complementation Z1_02550 YegN PHI:9198 W8ZK20 562 75.1 1036 257 1 6 1041 6 1040 0.0 1481.0 0 0 0 0 0 0 0 0 0 0 Z1_01001 Acs PHI:9227 P27550 562 78.6 650 139 0 1 650 1 650 0.0 1082.0 0 0 0 0 0 0 0 0 0 0 Z1_01032 GlmS PHI:9308 D4I4L2 552 79.5 609 124 1 1 608 1 609 0.0 942.0 0 0 0 0 0 0 0 0 0 0 Z1_01382 Pgi PHI:9310 D4I2T0 552 79.2 548 113 1 1 548 1 547 0.0 896.0 0 0 0 0 0 0 0 0 0 0 Z1_00542 MetE PHI:9315 D4HUM7 552 75.4 755 182 2 1 754 1 752 0.0 1174.0 0 0 0 0 0 0 0 0 0 0 Z1_00841 Ppc PHI:9322 D4HUG1 552 74.5 883 220 2 1 878 1 883 0.0 1319.0 0 0 0 0 0 0 0 0 0 0 Z1_01826 CysI3 PHI:9323 D4HWM2 552 75.4 564 138 1 8 571 9 571 0.0 890.0 0 0 0 0 0 0 0 0 0 0 Z1_02352 Pta PHI:9842 Q9KT08 666 73.6 713 187 1 1 712 1 713 0.0 1033.0 0 0 0 0 0 0 0 0 0 0 Z1_02657 MsrB PHI:4582 P0A088 1280 48.3 118 60 1 18 134 5 122 1.0100000000000001e-35 119.0 0 0 0 0 0 0 0 0 0 0 Z1_03367 TssC-2__EAMY__3227 PHI:7081__PHI:7443 D4I234 552 42.5 480 270 3 13 491 38 512 1.01e-134 397.0 0 0 0 0 0 0 0 0 0 0 Z1_03106 STM14_RS15345 PHI:10082 A0A0F6B5S8 28901 65.3 285 99 0 18 302 15 299 1.01e-137 390.0 ACY89872 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) Manganese/iron ABC transporter ATP-binding protein unaffected pathogenicity Gene deletion: full Z1_01797 PA3644 PHI:3785 Q9X6P4 287 46.2 210 104 3 60 267 56 258 1.01e-59 188.0 AF142597_1 Pseudomonas aeruginosa PAO1 Infection Beetles 7067 Tenebrio molitor (related: yellow mealworm) acyltransferases reduced virulence Altered gene expression / gene regulation: overexpression Z1_02471 CheZ__Chez PHI:10050 P07800 28901 70.3 202 57 1 17 218 16 214 1.01e-94 274.0 0 0 0 0 0 0 0 0 0 0 Z1_02441 LpxL1_(BN49_2155) PHI:7946 W9BFU2 573 64.4 306 109 0 1 306 1 306 1.0299999999999999e-147 416.0 0 0 0 0 0 0 0 0 0 0 Z1_00682 Hfq PHI:4064 Q8ZIW2 632 88.5 87 9 1 1 87 1 86 1.0300000000000001e-47 145.0 CAL19055 Yersinia pestis CO92 Pneumonic plague Rodents 10090 Mus musculus (related: house mouse) RNA-binding protein reduced virulence Gene mutation Z1_03462 MagA PHI:2652 Q5KQZ9 573 82.4 193 34 0 1 193 1 193 1.03e-115 325.0 0 0 0 0 0 0 0 0 0 0 Z1_00289 YdhX PHI:10998 P77375 562 68.6 223 69 1 1 223 1 222 1.03e-118 335.0 0 0 0 0 0 0 0 0 0 0 Z1_00086 Ser PHI:4073 V5XVU3 615 51.7 495 213 7 3 491 19 493 1.03e-128 381.0 BAO08779 Serratia marcescens 2170 Hemolymph bleeding Moths 7091 Bombyx mori (related: domestic silkworm) virulence factor reduced virulence Gene disruption Z1_01907 ADE2 PHI:196 Q92210 5476 47.9 163 83 1 11 173 396 556 1.04e-40 142.0 AAC49755 Candida albicans CAI-7 Candidiasis Rodents 10090 Mus musculus (related: house mouse) Phosphoribosylaminoimidazole carboxylase reduced virulence Gene disruption; gene complementation Z1_02267 Ndk PHI:6438 Q59636 287 68.8 141 44 0 1 141 1 141 1.05e-65 194.0 AAC44154 Pseudomonas aeruginosa PAO1 Nosocomial infection Rodents 10090 Mus musculus (related: house mouse) Host-responsive regulator/Nucleoside diphosphate kinase increased virulence (hypervirulence) Gene mutation Z1_01235 PstB PHI:3412 Q8PM59 346 66.1 248 84 0 11 258 20 267 1.06e-121 346.0 0 0 0 0 0 0 0 0 0 0 Z1_02445 TtrB PHI:604 Q9Z4S8 28901 79.9 244 49 0 1 244 7 250 1.06e-151 421.0 0 0 0 0 0 0 0 0 0 0 Z1_01369 Idi PHI:10966 A0A3M5LJ40 29438 43.5 131 74 0 2 132 3 133 1.06e-36 123.0 0 0 0 0 0 0 0 0 0 0 Z1_00741 Thioredoxin_1 PHI:2644 P0AA28 28901 82.4 108 19 0 1 108 1 108 1.08e-65 192.0 0 0 0 0 0 0 0 0 0 0 Z1_01999 CadC PHI:7387__PHI:11287 Q56405 1639 43.3 67 38 0 5 71 33 99 1.09e-12 58.2 0 0 0 0 0 0 0 0 0 0 Z1_00649 Mdh PHI:2959 C5BF98 67780 76.9 312 72 0 1 312 1 312 1.12e-164 459.0 0 0 0 0 0 0 0 0 0 0 Z1_00329 Eae PHI:7913 P43261 562 43.6 362 197 3 154 512 191 548 1.13e-83 295.0 0 0 0 0 0 0 0 0 0 0 Z1_01675 PA4916 PHI:4718 Q9HUP7 287 40.3 206 111 7 54 251 7 208 1.14e-36 128.0 AE004904_9 Pseudomonas aeruginosa PAO1-L Nosocomial infection Flies 7227 Drosophila melanogaster (related: fruit fly) unknown reduced virulence Gene mutation Z1_03384 YcbK PHI:11001 P0AB06 562 65.4 182 63 0 1 182 1 182 1.14e-86 251.0 0 0 0 0 0 0 0 0 0 0 Z1_02771 Grx4_(CNAG_02950) PHI:8615 J9VHR2 5207 47.2 89 47 0 11 99 145 233 1.16e-24 92.0 0 0 0 0 0 0 0 0 0 0 Z1_02368 NuoI_(PA2644) PHI:8937 Q9I0J4 287 78.5 181 36 1 3 180 2 182 1.16e-90 261.0 0 0 0 0 0 0 0 0 0 0 Z1_00869 CpxP PHI:8515 D2TU75 67825 55.7 106 41 2 73 176 42 143 1.1799999999999999e-25 95.5 0 0 0 0 0 0 0 0 0 0 Z1_00871 CpxA PHI:8513__PHI:8689 D2TU77 67825 79.2 452 94 0 1 452 1 452 1.17e-266 729.0 0 0 0 0 0 0 0 0 0 0 Z1_02790 PspB PHI:7658 A0A0F6B1X0 28901 66.7 75 23 1 1 75 1 73 1.1800000000000001e-29 98.6 0 0 0 0 0 0 0 0 0 0 Z1_00319 HybA PHI:10995 P0AAJ8 562 73.3 337 81 2 1 337 1 328 1.22e-190 526.0 0 0 0 0 0 0 0 0 0 0 Z1_03121 MAM_(YPK_1779) PHI:11187 A0A0H3B2K4 633 51.4 877 318 5 1 771 1 875 1.22e-313 878.0 0 0 0 0 0 0 0 0 0 0 Z1_01248 NtrB PHI:11699 Q9HU60 287 44.9 354 184 4 6 348 1 354 1.22e-90 274.0 0 0 0 0 0 0 0 0 0 0 Z1_02970 SssB PHI:3780 D0ZX10 28901 56.5 317 135 3 1 317 1 314 1.23e-120 347.0 0 0 0 0 0 0 0 0 0 0 Z1_03009 MdtJ PHI:8966 A0A1C1TY69 573 71.4 112 32 0 1 112 1 112 1.23e-44 140.0 0 0 0 0 0 0 0 0 0 0 Z1_03296 CigR PHI:3751 D0ZLQ3 28901 59.3 86 35 0 81 166 74 159 1.2499999999999999e-23 89.4 0 0 0 0 0 0 0 0 0 0 Z1_01872 AmpR PHI:10922 Q66T04 573 45.0 60 33 0 7 66 11 70 1.25e-06 47.4 0 0 0 0 0 0 0 0 0 0 Z1_01322 Tlp10_(Cj0019c) PHI:11081 Q0PCA6 197 45.2 84 46 0 331 414 392 475 1.25e-14 75.1 0 0 0 0 0 0 0 0 0 0 Z1_02728 YdcR PHI:7225 A0A0F6B1M0 28901 54.3 468 213 1 1 468 1 467 1.25e-174 497.0 0 0 0 0 0 0 0 0 0 0 Z1_01002 YjcH PHI:9228 P0AF54 562 61.8 102 39 0 1 102 1 102 1.25e-39 125.0 0 0 0 0 0 0 0 0 0 0 Z1_01792 PXO_01122 PHI:3895 B2SR06 347 40.0 440 250 6 11 446 12 441 1.25e-91 283.0 ACD59567 Xanthomonas oryzae pv. oryzae strain PXO99A Bacterial leaf blight Monocots 4530 Oryza sativa (related: rice) PDZ domain-containing proteases reduced virulence Gene disruption; gene complementation Z1_02359 AspC_(PXO_02420) PHI:9989 A0A0K0GPI8 347 43.2 389 221 0 9 397 14 402 1.2700000000000002e-110 329.0 0 0 0 0 0 0 0 0 0 0 Z1_02624 STM14_RS07760_(orf245) PHI:10111 A0A0F6B0X5 28901 67.8 245 79 0 1 245 1 245 1.27e-123 349.0 0 0 0 0 0 0 0 0 0 0 Z1_03458 Bcpgd PHI:9835 A0A384JMC8 40559 53.0 451 208 3 7 454 11 460 1.27e-168 482.0 0 0 0 0 0 0 0 0 0 0 Z1_00244 ClpP PHI:3040 P0A1D7 28901 85.0 207 31 0 1 207 1 207 1.2900000000000002e-125 351.0 BAA94668 Salmonella enterica subsp. enterica serovar Typhimurium strain C5 Food poisoning Rodents 10090 Mus musculus (related: house mouse) proteolytic component reduced virulence Gene deletion: full; gene complementation Z1_00640 GreA PHI:7130 P64281 28901 84.2 158 25 0 1 158 1 158 1.29e-92 264.0 0 0 0 0 0 0 0 0 0 0 Z1_02650 GntR PHI:11407 A6TAW6 573 77.8 234 52 0 1 234 1 234 1.2e-132 372.0 0 0 0 0 0 0 0 0 0 0 Z1_02203 Orf82_(VK055_1982) PHI:7477 D8L2S4 573 53.8 676 275 14 20 667 6 672 1.2e-232 660.0 0 0 0 0 0 0 0 0 0 0 Z1_02136 Krs_(BBA_03037) PHI:9409 J5K1T7 176275 40.4 513 278 9 15 502 82 591 1.3000000000000001e-110 338.0 0 0 0 0 0 0 0 0 0 0 Z1_02253 SuhB PHI:3915 Q02RX2 287 54.6 271 119 2 1 267 1 271 1.31e-94 278.0 ABJ13079 Pseudomonas aeruginosa PAK Nosocomial infection Rodents 10090 Mus musculus (related: house mouse) an essential gene for the T3SS gene expression loss of pathogenicity Gene mutation Z1_00872 GigX1 PHI:6953 A0A0J9WXH4 347 51.7 362 170 2 4 361 3 363 1.35e-128 372.0 0 0 0 0 0 0 0 0 0 0 Z1_02547 CreB PHI:11268 Q8ZJU6 28901 43.2 220 120 3 10 225 6 224 1.3899999999999998e-52 168.0 0 0 0 0 0 0 0 0 0 0 Z1_03399 HimD PHI:2673 P64394 28901 88.2 93 11 0 1 93 1 93 1.38e-57 170.0 0 0 0 0 0 0 0 0 0 0 Z1_01394 Alr-2 PHI:11459 A0KL98 644 54.8 363 161 3 1 363 1 360 1.3900000000000001e-132 382.0 0 0 0 0 0 0 0 0 0 0 Z1_01308 PpiA PHI:11417 A0A0D6I7L0 28901 75.4 167 41 0 21 187 22 188 1.3e-89 259.0 0 0 0 0 0 0 0 0 0 0 Z1_02592 GuaB_(Dda3937_00004) PHI:8579 E0SN64 204038 89.1 487 53 0 1 487 1 487 1.42e-304 827.0 0 0 0 0 0 0 0 0 0 0 Z1_03549 OdhB PHI:7353 Q2FH26 1280 42.9 431 200 12 5 401 3 421 1.42e-94 288.0 0 0 0 0 0 0 0 0 0 0 Z1_01463 GntK PHI:6701 A0A0H6FRN3 666 48.3 89 45 1 84 172 1 88 1.43e-20 80.1 0 0 0 0 0 0 0 0 0 0 Z1_03759 CsrA PHI:7161 D4HX67 552 96.6 59 2 0 1 59 1 59 1.44e-33 107.0 0 0 0 0 0 0 0 0 0 0 Z1_02287 PtsI PHI:9312 D4HXP6 552 77.7 575 128 0 1 575 1 575 1.46e-318 870.0 0 0 0 0 0 0 0 0 0 0 Z1_00298 PhoB PHI:8032 Q5GWK1 347 55.9 227 100 0 1 227 1 227 1.47e-93 272.0 AAW76920 Xanthomonas oryzae pv. oryzae strain PXO99A Bacterial leaf blight Monocots 4530 Oryza sativa (related: rice) Two-component signal transduction system response regulator unaffected pathogenicity Gene deletion: full Z1_00021 NqrC_(PA2997) PHI:8943 Q9HZK8 287 47.5 259 129 3 6 258 3 260 1.4899999999999999e-74 226.0 0 0 0 0 0 0 0 0 0 0 Z1_01442 InvA PHI:647__PHI:9467 P0A1I4 28901 50.8 691 324 4 10 699 10 685 1.4900000000000002e-224 641.0 0 0 0 0 0 0 0 0 0 0 Z1_02466 Tsr PHI:6981 A0A0F6BB74 28901 50.9 568 264 3 1 568 1 553 1.49e-114 350.0 0 0 0 0 0 0 0 0 0 0 Z1_03117 Prc PHI:9896 P23865 562 67.5 668 211 3 14 680 9 671 1.4e-317 877.0 BAA00577 Escherichia coli RS218 Urinary tract infection Rodents 10090 Mus musculus (related: house mouse) Tail-specific protease reduced virulence Gene mutation; gene complementation Z1_02084 LpxC PHI:10612 B2I1I9 470 51.2 297 144 1 2 298 1 296 1.5000000000000002e-110 321.0 0 0 0 0 0 0 0 0 0 0 Z1_03090 ArnB PHI:7949 A6TFA0 573 66.5 376 126 0 1 376 1 376 1.51e-189 527.0 0 0 0 0 0 0 0 0 0 0 Z1_00314 STM14_RS15315 PHI:10076 A0A0F6B5S1 28901 75.2 234 58 0 155 388 57 290 1.52e-126 364.0 ACY89865 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) Hydrogenase assembly chaperone unaffected pathogenicity Gene deletion: full Z1_01714 RfaE PHI:3147 B8F4X8 738 67.9 467 150 0 6 472 7 473 1.52e-227 631.0 0 0 0 0 0 0 0 0 0 0 Z1_02938 KdpB PHI:4712 P57698 287 58.2 677 257 7 15 685 33 689 1.52e-242 686.0 0 0 0 0 0 0 0 0 0 0 Z1_03015 ZnuA PHI:11005 P39172 562 58.0 314 121 3 1 310 1 307 1.54e-124 357.0 0 0 0 0 0 0 0 0 0 0 Z1_02369 NuoJ_(PA2645) PHI:8938 Q9I0J3 287 65.9 164 55 1 1 163 1 164 1.55e-65 196.0 0 0 0 0 0 0 0 0 0 0 Z1_00226 AdeI PHI:6386 Q2FD95 470 43.2 370 204 3 10 374 11 379 1.55e-93 285.0 0 0 0 0 0 0 0 0 0 0 Z1_01083 CjrB PHI:10793 C8CGJ1 562 42.1 76 43 1 176 251 162 236 1.56e-09 55.5 0 0 0 0 0 0 0 0 0 0 Z1_00737 EpsC PHI:7052 Q8DTB7 1309 51.9 370 169 2 1 369 4 365 1.59e-125 365.0 0 0 0 0 0 0 0 0 0 0 Z1_02462 MotA PHI:6361 A0A0E9B8Z9 553 68.3 284 90 0 1 284 9 292 1.5e-138 391.0 0 0 0 0 0 0 0 0 0 0 Z1_03672 GnoA PHI:3277 Q4WIQ3 746128 64.4 365 129 1 4 367 12 376 1.5e-172 484.0 0 0 0 0 0 0 0 0 0 0 Z1_03536 TolA PHI:3472 Q8X965 562 54.4 90 40 1 267 355 305 394 1.5e-24 101.0 AAG55075 Escherichia coli TW14359 Infection Moths 7137 Galleria mellonella (related: greater wax moth) Periplasm spanning protein reduced virulence Gene mutation; gene complementation Z1_01289 PdeC__PdeA PHI:8644__PHI:8642 D4I4B4 552 42.5 226 123 2 4 225 2 224 1.5e-49 170.0 0 0 0 0 0 0 0 0 0 0 Z1_02474 HxfA_(PD_2118)_(pspA) PHI:3659 Q879S6 2371 40.0 55 33 0 82 136 128 182 1.61e-06 48.9 0 0 0 0 0 0 0 0 0 0 Z1_03535 TolB PHI:10905 D2TPE2 67825 81.0 431 81 1 1 431 1 430 1.61e-156 447.0 0 0 0 0 0 0 0 0 0 0 Z1_00772 RsmB PHI:2694 Q6D000 29471 68.5 428 128 1 1 421 1 428 1.62e-216 599.0 0 0 0 0 0 0 0 0 0 0 Z1_01795 PA3646 PHI:3784 Q9HXY6 287 52.2 335 160 0 3 337 6 340 1.62e-82 253.0 AE004784_7 Pseudomonas aeruginosa PAO1 Infection Beetles 7067 Tenebrio molitor (related: yellow mealworm) acyltransferases reduced virulence Altered gene expression / gene regulation: overexpression Z1_02249 GlyA PHI:2962 C5BEV2 67780 86.8 417 55 0 1 417 1 417 1.63e-272 740.0 0 0 0 0 0 0 0 0 0 0 Z1_02322 XC_1565 PHI:3966 Q4UWE2 339 47.5 297 150 3 9 302 5 298 1.63e-87 263.0 AAY48631 Xanthomonas campestris pv. campestris strain 8004 Black rot Eudicots 3726 Raphanus sativus (related: radish) N-5-glutamine S-adenosyl-L-methionine-dependent methyltransferase reduced virulence Gene mutation Z1_02063 LeuC PHI:8964 W9BBU8 573 83.8 463 75 0 1 463 1 463 1.65e-286 780.0 0 0 0 0 0 0 0 0 0 0 Z1_00493 FleQ PHI:3219 Q5GZM8 347 43.7 350 155 6 218 531 142 485 1.65e-76 248.0 0 0 0 0 0 0 0 0 0 0 Z1_03400 GzOB019 PHI:1579 I1RM25 5518 41.6 77 37 3 196 264 229 305 1.67e-08 55.8 FGSG_05002 Fusarium graminearum GZ3639 Fusarium ear blight Monocots 4564 Triticum (related: wheat) transcription factor unaffected pathogenicity Gene deletion Z1_01362 XC_0509 PHI:3942 Q4UZD3 339 65.7 426 145 1 1 426 1 425 1.67e-192 539.0 AAY47590 Xanthomonas campestris pv. campestris strain 8004 Black rot Eudicots 3726 Raphanus sativus (related: radish) Phosphoribosylamine-glycine ligase reduced virulence Gene mutation Z1_00492 STM14_RS15255 PHI:10064 A0A0F6B5Q6 28901 62.2 185 66 1 1 185 1 181 1.67e-84 245.0 ACY89850 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) Hypothetical protein unaffected pathogenicity Gene deletion: full Z1_00023 NqrA_(PA2999) PHI:8945 Q9HZK6 287 58.3 446 185 1 1 446 1 445 1.69e-178 504.0 0 0 0 0 0 0 0 0 0 0 Z1_03060 FTT0673p/prsAp PHI:4732 Q5NH02 263 55.4 314 135 4 3 313 4 315 1.6e-122 352.0 CAG45307 Francisella tularensis SCHU S4 Tularemia Rodents 10090 Mus musculus (related: house mouse) ribose phosphate pyrophosphokinase unaffected pathogenicity Gene mutation Z1_02871 VK055_1961 PHI:7511 A0A076ZHT9 573 47.6 248 126 3 3 247 1 247 1.7000000000000002e-72 220.0 AIK80567 Klebsiella pneumoniae KPPR1 Pneumonia Rodents 10090 Mus musculus (related: house mouse) Serine 3-dehydrogenase unaffected pathogenicity Gene deletion: full Z1_02956 AhpC PHI:11383 P0A251 28901 87.7 187 23 0 1 187 1 187 1.71e-127 354.0 0 0 0 0 0 0 0 0 0 0 Z1_01371 MetA PHI:9313 D4I2T4 552 73.8 309 81 0 1 309 1 309 1.71e-169 471.0 0 0 0 0 0 0 0 0 0 0 Z1_02673 Hns PHI:6369 P0ACF8 562 77.0 135 30 1 1 134 1 135 1.71e-61 183.0 0 0 0 0 0 0 0 0 0 0 Z1_01247 NtrC PHI:10343 A0A072ZJC4 287 62.4 465 169 3 6 470 7 465 1.72e-207 580.0 0 0 0 0 0 0 0 0 0 0 Z1_02353 AckA PHI:9843 A0A0H3Q0Y8 666 72.1 398 107 3 3 399 2 396 1.73e-207 574.0 0 0 0 0 0 0 0 0 0 0 Z1_03688 Cab_(NMB0789) PHI:8623 Q9K033 487 48.8 246 119 1 1 239 1 246 1.73e-73 222.0 0 0 0 0 0 0 0 0 0 0 Z1_02070 RsmH PHI:4961 P60392 1280 42.8 313 166 6 6 311 2 308 1.73e-75 232.0 0 0 0 0 0 0 0 0 0 0 Z1_03229 CobB_(Yp_1760) PHI:8898 Q8ZFR1 632 71.7 269 74 2 4 272 1 267 1.74e-139 392.0 0 0 0 0 0 0 0 0 0 0 Z1_03405 XacFhaB PHI:5388 Q8PLI3 346 43.6 110 40 3 52 141 74 181 1.75e-16 80.5 AAM36677 Xanthomonas citri subsp. citri strain 99-1330 Canker (citrus) Eudicots 2711 Citrus sinensis (related: sweet orange) Virulence factor/non-fimbrial adhesin protein reduced virulence Functional test in host: transient expression Z1_02820 TrpC_(PXO_04004) PHI:9984 B2SL03 347 43.6 257 137 4 3 251 4 260 1.76e-54 181.0 0 0 0 0 0 0 0 0 0 0 Z1_00423 PtsN PHI:3133 Q665I9 633 70.5 149 43 1 1 149 7 154 1.76e-72 213.0 0 0 0 0 0 0 0 0 0 0 Z1_02032 PA0423 PHI:3166 Q9I690 287 63.9 191 69 0 1 191 1 191 1.77e-90 261.0 AE004479_7 Pseudomonas aeruginosa PAO1 Nosocomial infection Primates 9606 Homo sapiens (related: human) factor responsible for cytotoxicity in lung epithelial cells reduced virulence Gene mutation Z1_02539 BfvR_(YPO1737) PHI:8505 Q7CHU5 632 81.0 121 23 0 1 121 1 121 1.78e-71 208.0 0 0 0 0 0 0 0 0 0 0 Z1_02686 Bab2_0700 PHI:9130 Q2YKG0 235 40.5 499 286 10 42 536 25 516 1.79e-114 348.0 0 0 0 0 0 0 0 0 0 0 Z1_03702 LipA PHI:6492 V5VBJ6 470 58.8 320 129 2 1 320 1 317 1.7e-134 384.0 0 0 0 0 0 0 0 0 0 0 Z1_01372 MLS1__Mls1 PHI:365__PHI:2267 Q5J4D6 13684 46.7 508 259 8 21 522 23 524 1.7e-150 440.0 0 0 0 0 0 0 0 0 0 0 Z1_03453 HisA PHI:9324 D4HW76 552 71.3 244 70 0 1 244 1 244 1.8000000000000002e-123 349.0 0 0 0 0 0 0 0 0 0 0 Z1_00028 LysA_(Dda3937_02577) PHI:8581 E0SEI0 204038 71.9 402 113 0 10 411 17 418 1.81e-211 586.0 0 0 0 0 0 0 0 0 0 0 Z1_01460 NiuD PHI:6849 D7FDG3 210 42.0 317 173 6 17 329 15 324 1.82e-62 200.0 0 0 0 0 0 0 0 0 0 0 Z1_02446 STM14_RS07775_(ttrC) PHI:10114 A0A0F6B0X8 28901 47.2 335 176 1 8 342 7 340 1.8300000000000002e-110 323.0 0 0 0 0 0 0 0 0 0 0 Z1_00001 RecA PHI:10380 A3M645 470 72.2 327 91 0 3 329 1 327 1.8400000000000002e-169 474.0 ABO12389 Acinetobacter baumannii ATCC 17978 Nosocomial infection Nematodes 6239 Caenorhabditis elegans (related: roundworm) DNA strand exchange and recombination protein reduced virulence Gene deletion: full; gene complementation Z1_00158 XC_0892 PHI:3950 Q4UYA7 339 61.5 423 162 1 2 424 4 425 1.84e-193 541.0 AAY47966 Xanthomonas campestris pv. campestris strain 8004 Black rot Eudicots 3726 Raphanus sativus (related: radish) Glutamate-1-semialdehyde aminotransferase reduced virulence Gene mutation Z1_00707 PldA_(CBU_0489) PHI:7998 Q83E43 777 41.0 210 113 6 85 291 143 344 1.84e-41 144.0 0 0 0 0 0 0 0 0 0 0 Z1_02289 MecA PHI:6556 Q4X256 746128 41.7 314 170 7 9 313 18 327 1.84e-64 210.0 0 0 0 0 0 0 0 0 0 0 Z1_03418 Lrp PHI:6497__PHI:7128 D3VBH2 628 98.8 164 2 0 1 164 1 164 1.85e-113 317.0 0 0 0 0 0 0 0 0 0 0 Z1_00257 XC_3703 PHI:3259 Q4UQD0 339 48.8 164 80 3 25 187 1 161 1.85e-43 140.0 AAY50743 Xanthomonas campestris pv. campestris strain 8004 Black rot Eudicots 3726 Raphanus sativus (related: radish) Cyclic di-GMP Effectors effector (plant avirulence determinant) Gene deletion: full Z1_03446 Smp PHI:7699 Q4ZTI4 317 40.4 193 114 1 1 192 1 193 1.86e-45 148.0 AAY37538 Pseudomonas syringae pv. syringae strain B728a Brown spot (bean) Eudicots 3885 Phaseolus vulgaris (related: kidney bean) Swarm motility-promoting regulatory protein unaffected pathogenicity Gene mutation; gene complementation Z1_01027 AtpA PHI:10773 Q2FWE8 1280 55.9 490 205 2 1 490 1 479 1.87e-184 525.0 0 0 0 0 0 0 0 0 0 0 Z1_00346 YaaA PHI:11408 A0A378CFB4 573 73.9 257 66 1 1 257 294 549 1.8899999999999998e-126 368.0 0 0 0 0 0 0 0 0 0 0 Z1_01199 MetF PHI:9325 D4HUG0 552 80.5 297 58 0 1 297 1 297 1.8899999999999998e-180 498.0 0 0 0 0 0 0 0 0 0 0 Z1_00447 PccS1_001523 PHI:10577 C6DIJ6 554 95.9 98 4 0 1 98 1 98 1.91e-61 180.0 ACT11296 Pectobacterium carotovorum subsp. carotovorum strain PccS1 Soft rot Monocots 69721 Zantedeschia aethiopica (related: arum-lily) Transcriptional regulator, Fis family, Fis unaffected pathogenicity Gene deletion: full; gene complementation Z1_02560 PurN PHI:8652 P08179 562 66.8 202 67 0 3 204 2 203 1.91e-94 273.0 0 0 0 0 0 0 0 0 0 0 Z1_00431 XC_1510 PHI:3952 Q4UWJ5 339 60.5 479 185 1 2 480 5 479 1.92e-195 550.0 AAY48578 Xanthomonas campestris pv. campestris strain 8004 Black rot Eudicots 3726 Raphanus sativus (related: radish) TldD protein, DNA gyrase control? reduced virulence Gene mutation Z1_00865 PfkA PHI:9309 D4HUC7 552 83.2 321 52 1 5 325 2 320 1.96e-198 545.0 0 0 0 0 0 0 0 0 0 0 Z1_00124 Tkt PHI:8028 Q8MPM3 5665 47.0 676 324 11 1 664 1 654 1.98e-193 560.0 CAD20572 Leishmania mexicana M379 Leishmaniasis Primates 9606 Homo sapiens (related: human) Transketolase loss of pathogenicity Gene deletion: full; gene complementation Z1_00408 MurA PHI:7630 Q9HVW7 287 60.4 419 163 2 1 416 1 419 1.99e-174 492.0 0 0 0 0 0 0 0 0 0 0 Z1_02789 PspA PHI:7657 A0A0F6B1X1 28901 71.0 217 63 0 1 217 1 217 1.99e-97 281.0 0 0 0 0 0 0 0 0 0 0 Z1_01715 YqiC PHI:6697 A0A0U1J4N7 28901 71.1 83 24 0 1 83 1 83 1.9e-35 115.0 0 0 0 0 0 0 0 0 0 0 Z1_00535 UbiE PHI:10294 W8TW76 1280 42.0 226 128 1 25 250 11 233 1e-59 187.0 0 0 0 0 0 0 0 0 0 0 Z1_00829 ArgG PHI:9316 D4HUG4 552 83.3 401 67 0 3 403 4 404 2.01e-250 683.0 0 0 0 0 0 0 0 0 0 0 Z1_03274 PA2769 PHI:10776 Q9I074 287 42.4 118 61 4 5 120 6 118 2.0300000000000002e-21 82.0 AE004704_11 Pseudomonas aeruginosa PAO1161 Infection Nematodes 6239 Caenorhabditis elegans (related: roundworm) Nudix hydrolase domain-containing protein unaffected pathogenicity Gene deletion: full; gene complementation Z1_00384 Urease_(MAA_07458) PHI:9533 E9F5A9 568076 62.0 571 210 4 1 567 270 837 2.0300000000000002e-252 712.0 0 0 0 0 0 0 0 0 0 0 Z1_00799 GzOB009 PHI:1569 I1RCH5 5518 48.5 301 114 9 7 268 59 357 2.0399999999999998e-74 230.0 FGSG_01290 Fusarium graminearum GZ3639 Fusarium ear blight Monocots 4564 Triticum (related: wheat) transcription factor lethal Gene deletion Z1_01437 STM14_RS15405_(prgI) PHI:10094 A0A0F6B5U1 28901 46.4 69 37 0 16 84 12 80 2.03e-12 55.5 0 0 0 0 0 0 0 0 0 0 Z1_02461 FlhC_(Dda3937_02784) PHI:8572 E0SIM9 204038 82.3 186 32 1 1 186 1 185 2.0499999999999998e-108 306.0 0 0 0 0 0 0 0 0 0 0 Z1_01389 SSBX PHI:2737 Q5H2X8 347 56.5 115 46 2 3 117 2 112 2.04e-40 133.0 AAW74693 Xanthomonas oryzae pv. oryzicola strain RS105 Leaf blight Monocots 4530 Oryza sativa (related: rice) Single-stranded DNA-binding protein reduced virulence Gene deletion: full Z1_03573 Fur PHI:11509 Q7CQY3 28901 86.4 147 20 0 1 147 1 147 2.04e-96 273.0 0 0 0 0 0 0 0 0 0 0 Z1_03554 SdhC PHI:7962 P69054 562 74.7 91 23 0 3 93 39 129 2.05e-45 140.0 0 0 0 0 0 0 0 0 0 0 Z1_02064 LeuB PHI:8963 W9BCN0 573 78.2 362 79 0 1 362 1 362 2.06e-211 581.0 0 0 0 0 0 0 0 0 0 0 Z1_02469 CheB PHI:6461 P04042 28901 76.6 350 81 1 1 350 1 349 2.07e-188 522.0 0 0 0 0 0 0 0 0 0 0 Z1_00756 HdfR_(Dda3937_04419) PHI:8567 E0SLG2 204038 58.5 272 111 2 1 271 5 275 2.08e-104 303.0 0 0 0 0 0 0 0 0 0 0 Z1_00241 HupB_(XAC1081) PHI:8676 Q8NL12 346 71.1 90 26 0 1 90 1 90 2.08e-39 124.0 0 0 0 0 0 0 0 0 0 0 Z1_02593 Gua1 PHI:6871 J9VUY6 5207 49.0 543 255 6 2 524 3 543 2.0900000000000002e-179 514.0 0 0 0 0 0 0 0 0 0 0 Z1_02604 Rdf PHI:9805 A0A6C7HRI3 28901 40.0 55 33 0 3 57 6 60 2.09e-08 45.1 0 0 0 0 0 0 0 0 0 0 Z1_03752 GshA PHI:9280__PHI:11327 Q9HTY6 287 40.4 520 287 10 8 516 10 517 2.1100000000000002e-117 355.0 0 0 0 0 0 0 0 0 0 0 Z1_02750 STM14_RS07725_(ynhA/sufE) PHI:10103 A0A0F6B0W8 28901 52.8 127 60 0 3 129 1 127 2.1200000000000003e-43 138.0 0 0 0 0 0 0 0 0 0 0 Z1_02392 RcsC11 PHI:3011 P58662 28901 43.6 926 503 8 1 917 24 939 2.12e-256 740.0 0 0 0 0 0 0 0 0 0 0 Z1_00240 PrsA2 PHI:6137__PHI:7070 Q71XE6 1639 41.5 94 51 2 276 367 143 234 2.13e-10 60.5 0 0 0 0 0 0 0 0 0 0 Z1_01097 Int PHI:9804 Q9X961 28901 100.0 37 0 0 1 37 1 37 2.13e-18 75.9 0 0 0 0 0 0 0 0 0 0 Z1_02004 Eda PHI:6699 A0A0H6T2F5 666 52.6 196 92 1 9 204 7 201 2.13e-70 211.0 0 0 0 0 0 0 0 0 0 0 Z1_01318 Aer PHI:6979 A0A0F6B6Z9 28901 40.7 514 297 3 1 514 1 506 2.14e-114 346.0 0 0 0 0 0 0 0 0 0 0 Z1_03448 Prt PHI:5109 B5QZL1 28901 86.6 299 40 0 1 299 1 299 2.15e-181 500.0 0 0 0 0 0 0 0 0 0 0 Z1_02090 PA4400 PHI:10781 Q9HW06 287 43.4 122 69 0 5 126 2 123 2.1900000000000002e-29 106.0 AE004855_10 Pseudomonas aeruginosa PAO1161 Infection Nematodes 6239 Caenorhabditis elegans (related: roundworm) Probable pyrophosphohydrolase reduced virulence Gene deletion: full; gene complementation Z1_01526 STM14_RS15265 PHI:10066 A0A0F6B5Q9 28901 64.8 142 50 0 10 151 4 145 2.2199999999999998e-67 200.0 ACY89853 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) Formate hydrogenlyase maturation protein unaffected pathogenicity Gene deletion: full Z1_03118 ProQ PHI:8783 P60317 28901 62.7 244 61 5 1 230 1 228 2.21e-83 246.0 AAL20761 Salmonella enterica subsp. enterica serovar Typhimurium strain SL1344 Salmonellosis Rodents 10090 Mus musculus (related: house mouse) RNA chaperone  reduced virulence Gene mutation; gene complementation Z1_00204 PCC21__023220 PHI:3711 J7KWZ6 554 52.5 200 94 1 11 210 9 207 2.25e-68 206.0 0 0 0 0 0 0 0 0 0 0 Z1_02464 CheA PHI:6535 P07363 562 61.3 729 196 7 1 727 3 647 2.2699999999999997e-282 788.0 0 0 0 0 0 0 0 0 0 0 Z1_03285 RplY PHI:7469 C6DEJ2 554 66.7 93 31 0 1 93 1 93 2.26e-40 127.0 ACT12677 Pectobacterium carotovorum subsp. carotovorum strain PccS1 Soft rot Monocots 94108 Zantedeschia elliottiana (no common name found) 50S Ribosomal protein reduced virulence Gene deletion: full; gene complementation Z1_02057 SpeB PHI:9150 P60651 562 81.8 302 55 0 5 306 3 304 2.2799999999999998e-191 526.0 0 0 0 0 0 0 0 0 0 0 Z1_03014 Ypo2062 PHI:4185 Q0WF94 632 66.4 423 133 4 22 441 1 417 2.2799999999999998e-197 551.0 0 0 0 0 0 0 0 0 0 0 Z1_02656 GAPDH PHI:6904 P0A038 1280 47.5 337 167 6 1 331 1 333 2.27e-102 302.0 CAB38645 Staphylococcus aureus USA300 JE2 White muscardine Moths 7137 Galleria mellonella (related: greater wax moth) Glyceraldehyde-3-phosphate dehydrogenase reduced virulence Functional test in host: direct injection Z1_03685 AatJ_(PSPTO_4171) PHI:10621 Q87XK7 317 58.2 292 114 2 12 295 7 298 2.27e-114 330.0 0 0 0 0 0 0 0 0 0 0 Z1_02055 MGG_00383 PHI:877 G4NCL5 318829 53.6 373 167 4 3 369 15 387 2.27e-135 390.0 MGG_00383 Magnaporthe oryzae KJ201 Blast (rice) Monocots 4530 Oryza sativa (related: rice) Hypothetical protein reduced virulence Gene disruption Z1_02764 LhnR PHI:3491 Q0GPY7 373 41.7 72 42 0 7 78 20 91 2.32e-07 49.7 0 0 0 0 0 0 0 0 0 0 Z1_00734 RmlA PHI:7634 Q9HU22 287 66.3 285 96 0 2 286 4 288 2.32e-138 390.0 0 0 0 0 0 0 0 0 0 0 Z1_03081 RamA PHI:5370 Q57RZ3 28901 47.3 110 54 2 1 108 3 110 2.3400000000000003e-32 108.0 0 0 0 0 0 0 0 0 0 0 Z1_02671 GalU PHI:3112 Q8P8Q1 339 48.8 297 143 3 6 301 3 291 2.37e-87 261.0 0 0 0 0 0 0 0 0 0 0 Z1_03528 AroG1 PHI:8884 Q8XW15 305 62.5 352 129 1 1 349 1 352 2.38e-157 444.0 0 0 0 0 0 0 0 0 0 0 Z1_01399 PotA PHI:6319 Q8DPC2 1313 53.1 288 127 3 9 294 4 285 2.38e-92 280.0 0 0 0 0 0 0 0 0 0 0 Z1_00186 EfeB PHI:10992 P31545 562 50.1 407 197 2 20 420 14 420 2.42e-144 416.0 0 0 0 0 0 0 0 0 0 0 Z1_00351 ArcA PHI:6532 P0A9Q1 562 92.0 238 19 0 1 238 1 238 2.42e-159 439.0 0 0 0 0 0 0 0 0 0 0 Z1_01411 Vatr1 PHI:3027 A5CUE1 28447 43.4 53 30 0 16 68 19 71 2.43e-06 44.7 CAN02728 Clavibacter michiganensis subsp. michiganensis strain NCPPB382 Wilt (tomato); canker (tomato) Eudicots 4081 Solanum lycopersicum (related: tomato) TetR family of transcriptional regulators reduced virulence Gene disruption; gene complementation Z1_00907 WaaA PHI:7635 Q9HUH7 287 51.4 418 200 3 5 420 5 421 2.44e-135 393.0 0 0 0 0 0 0 0 0 0 0 Z1_02749 STM14_RS07720_(sufS) PHI:10102 A0A0F6B0W7 28901 63.1 412 146 1 2 413 1 406 2.44e-184 516.0 0 0 0 0 0 0 0 0 0 0 Z1_00038 PilT PHI:6363 A0A0U1YU79 553 54.1 331 151 1 1 331 1 330 2.4599999999999997e-115 335.0 0 0 0 0 0 0 0 0 0 0 Z1_00416 KdsD PHI:7067 Q5NGP7 263 51.3 312 147 3 12 320 14 323 2.45e-100 296.0 YP_169795 Francisella tularensis SCHU S4 Tularemia Rodents 10090 Mus musculus (related: house mouse) D-arabinose 5-phosphate isomerase reduced virulence Gene disruption; gene complementation Z1_00623 CshA__Lmo0866 PHI:6510__PHI:7620 Q8Y8N0 1639 43.8 429 232 3 9 435 4 425 2.4999999999999998e-112 344.0 0 0 0 0 0 0 0 0 0 0 Z1_01909 PpiB PHI:11418 A0A0F7DI09 28901 83.5 164 27 0 1 164 1 164 2.49e-102 289.0 0 0 0 0 0 0 0 0 0 0 Z1_00340 NhaA PHI:3266 P13738 562 59.9 374 149 1 5 377 4 377 2.4e-155 441.0 0 0 0 0 0 0 0 0 0 0 Z1_01475 GbpA PHI:5560 Q7MEW9 672 49.2 179 84 2 30 201 22 200 2.4e-58 189.0 0 0 0 0 0 0 0 0 0 0 Z1_00693 Orn PHI:6274 P57665 287 69.1 178 55 0 3 180 2 179 2.52e-87 252.0 AE004908_2 Pseudomonas aeruginosa PA14 Opportunistic infection Rodents 10090 Mus musculus (related: house mouse) Oligoribonuclease reduced virulence Gene mutation Z1_02101 LpdA PHI:6520 Q5ZVD8 446 62.3 475 177 2 1 474 6 479 2.5400000000000003e-208 583.0 AAU27584 Legionella pneumophila 130b Legionnaires' disease Rodents 10090 Mus musculus (related: house mouse) Effector (plant avirulence determinant) effector (plant avirulence determinant) Gene deletion: full Z1_02833 SodCI PHI:9808__PHI:11378 P0CW86 28901 52.9 172 81 0 3 174 5 176 2.5400000000000003e-56 173.0 0 0 0 0 0 0 0 0 0 0 Z1_01778 GlcB PHI:6309 A8Z3D6 1280 47.7 509 227 8 1 470 1 509 2.56e-138 412.0 0 0 0 0 0 0 0 0 0 0 Z1_02228 RNase_III PHI:3724 Q56056 28901 85.4 226 33 0 1 226 1 226 2.56e-139 387.0 0 0 0 0 0 0 0 0 0 0 Z1_02162 Eco PHI:4101 Q63W37 28450 43.5 131 73 1 23 153 44 173 2.59e-37 124.0 CAH35049 Burkholderia pseudomallei K96423 Melioidosis Rodents 10090 Mus musculus (related: house mouse) serine protease inhibitor reduced virulence Gene mutation Z1_01240 OmpR PHI:11693 P0AA16 562 87.8 237 29 0 1 237 1 237 2.5e-155 429.0 0 0 0 0 0 0 0 0 0 0 Z1_00922 PyrE_(Dda3937_03258) PHI:8576 E0SLM3 204038 77.0 213 49 0 1 213 1 213 2.61e-119 336.0 0 0 0 0 0 0 0 0 0 0 Z1_00251 XAC1258 PHI:4147 Q8PN16 346 54.4 281 118 5 17 289 20 298 2.62e-103 303.0 AAM36129 Xanthomonas citri subsp. citri Canker (citrus) Eudicots 2711 Citrus sinensis (related: sweet orange) CyoA, cytochrome O ubiquinol oxidase reduced virulence Gene mutation Z1_03017 ZnuB PHI:5013 A0A0H3B439 633 72.9 255 69 0 1 255 1 255 2.62e-119 340.0 0 0 0 0 0 0 0 0 0 0 Z1_01375 Eda PHI:11149 Q6D4B5 29471 79.7 212 43 0 1 212 1 212 2.62e-121 341.0 0 0 0 0 0 0 0 0 0 0 Z1_03084 ArnF PHI:7955 A6TF94 573 42.5 120 67 2 4 123 2 119 2.6600000000000002e-21 81.3 0 0 0 0 0 0 0 0 0 0 Z1_01000 SodA PHI:11376 P43019 28901 77.2 206 46 1 1 206 1 205 2.6699999999999998e-120 338.0 0 0 0 0 0 0 0 0 0 0 Z1_00531 TatB PHI:8758 A0A0U1FMH1 28901 77.8 99 21 1 1 99 1 98 2.6799999999999996e-42 138.0 0 0 0 0 0 0 0 0 0 0 Z1_03004 YeaZ PHI:6870 A0A165G9C3 669 54.9 233 105 0 1 233 1 233 2.68e-86 254.0 0 0 0 0 0 0 0 0 0 0 Z1_00659 TamA PHI:10714 D4F0Q0 636 59.3 580 234 1 1 580 1 578 2.69e-264 733.0 0 0 0 0 0 0 0 0 0 0 Z1_02337 AccD PHI:10348 Q5HF73 1280 47.0 264 137 1 13 276 17 277 2.6e-75 231.0 0 0 0 0 0 0 0 0 0 0 Z1_00499 NarI PHI:10515 P11350 562 77.3 225 51 0 1 225 1 225 2.7000000000000003e-129 362.0 0 0 0 0 0 0 0 0 0 0 Z1_02288 PtsH PHI:9311 D4HXP5 552 87.1 85 11 0 1 85 1 85 2.74e-46 141.0 0 0 0 0 0 0 0 0 0 0 Z1_03705 CspE PHI:7263 A0A0F6AYC2 28901 85.5 69 10 0 1 69 1 69 2.7699999999999997e-41 127.0 0 0 0 0 0 0 0 0 0 0 Z1_03501 MoaA PHI:10987 P30745 562 73.6 326 84 1 3 326 4 329 2.76e-182 504.0 0 0 0 0 0 0 0 0 0 0 Z1_00532 TatA PHI:8757 A0A0U1FZZ2 28901 61.4 88 30 1 1 88 1 84 2.78e-26 90.9 0 0 0 0 0 0 0 0 0 0 Z1_00369 DedA PHI:11405 W9B383 573 74.4 215 55 0 1 215 1 215 2.79e-113 321.0 0 0 0 0 0 0 0 0 0 0 Z1_00606 mG PHI:10212 B0LF87 573 53.3 165 76 1 5 169 2 165 2.7e-57 175.0 0 0 0 0 0 0 0 0 0 0 Z1_00740 Rho PHI:8558 T1YC56 1280 52.0 415 190 5 7 419 24 431 2.8099999999999996e-147 424.0 AGU62228 Staphylococcus aureus HG001 Nosocomial infection Rodents 10090 Mus musculus (related: house mouse) Transcriptional regulator increased virulence (hypervirulence) Gene mutation; gene complementation Z1_00135 C2516 PHI:11344 A0A0H2V4D2 562 70.9 340 99 0 19 358 10 349 2.82e-161 454.0 0 0 0 0 0 0 0 0 0 0 Z1_00022 NqrB_(PA2998) PHI:8944 Q9HZK7 287 66.7 412 127 4 1 412 1 402 2.82e-201 559.0 0 0 0 0 0 0 0 0 0 0 Z1_03249 FabG1 PHI:5271 Q8Y0J2 305 63.1 244 87 1 3 243 5 248 2.8300000000000003e-97 283.0 0 0 0 0 0 0 0 0 0 0 Z1_00804 Bfr_(atu2771) PHI:10827 Q7CWA3 358 50.3 149 74 0 1 149 9 157 2.85e-44 142.0 0 0 0 0 0 0 0 0 0 0 Z1_02155 ExsA__Exsa PHI:6399__PHI:6992__PHI:8765 P26993 287 47.4 249 130 1 24 272 20 267 2.85e-75 229.0 0 0 0 0 0 0 0 0 0 0 Z1_03340 Ompk35__OmpK35 PHI:9529__PHI:10186 O87753 573 54.2 373 155 6 1 371 1 359 2.8600000000000004e-129 373.0 0 0 0 0 0 0 0 0 0 0 Z1_02062 LeuD PHI:8965 W9BQ45 573 78.2 197 43 0 3 199 4 200 2.86e-112 317.0 0 0 0 0 0 0 0 0 0 0 Z1_02701 VK055_1952 PHI:7520 A0A076ZMY5 573 75.9 485 114 2 8 491 5 487 2.8799999999999998e-263 723.0 AIK80558 Klebsiella pneumoniae KPPR1 Pneumonia Rodents 10090 Mus musculus (related: house mouse) Betaine aldehyde dehydrogenase unaffected pathogenicity Gene deletion: full Z1_02811 TonB PHI:6651 P45610 573 46.9 96 46 2 144 238 149 240 2.8899999999999995e-23 92.8 0 0 0 0 0 0 0 0 0 0 Z1_00739 WecA PHI:4074 V6A547 615 77.9 353 78 0 1 353 21 373 2.88e-200 553.0 0 0 0 0 0 0 0 0 0 0 Z1_02988 PSPTO_4541 PHI:10942 Q87WK5 317 43.1 102 44 2 358 445 377 478 2.8e-14 73.6 AAO57989 Pseudomonas syringae pv. tomato strain DC3000 Bacterial speck Eudicots 4081 Solanum lycopersicum (related: tomato) Methyl-accepting chemotaxis protein unaffected pathogenicity Gene deletion: full; gene complementation Z1_00981 PCK1 PHI:424 F5HAA8 5207 47.4 504 247 9 44 537 53 548 2.8e-145 427.0 EAL19243 Cryptococcus neoformans H99 Cryptococcosis Rodents 10090 Mus musculus (related: house mouse) Phosphoenolpyruvate carboxykinase reduced virulence Gene deletion; gene complementation Z1_03326 Rmf3 PHI:3676__PHI:3682 D4I0C5 552 80.4 51 10 0 1 51 1 51 2.9100000000000004e-26 88.6 0 0 0 0 0 0 0 0 0 0 Z1_01157 STM14_1285_(AsiR) PHI:11065 A0A0F6AZV0 28901 74.1 286 73 1 8 292 7 292 2.93e-144 405.0 0 0 0 0 0 0 0 0 0 0 Z1_03109 STM14_RS15360 PHI:10085 A0A0F6B5T1 28901 54.8 259 117 0 9 267 7 265 2.94e-93 275.0 ACY89875 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) Putative inner membrane protein unaffected pathogenicity Gene deletion: full Z1_02323 AroB PHI:7654 Q4WJ77 746128 43.4 389 183 7 7 358 5 393 2.9500000000000003e-97 293.0 0 0 0 0 0 0 0 0 0 0 Z1_03273 ANP1 PHI:3793 Q6FM27 5478 47.1 263 137 2 5 266 15 276 2.97e-80 244.0 CAG61680 Candida glabrata CBS 138 Disseminated candidiasis Rodents 10090 Mus musculus (related: house mouse) encode alpha -(1-6)-mannosyl-transferases increased virulence (hypervirulence) Gene disruption; gene complementation Z1_00277 NrdR PHI:3464 P67320 1314 45.6 147 80 0 1 147 1 147 2.9800000000000002e-43 139.0 0 0 0 0 0 0 0 0 0 0 Z1_01031 LpxA PHI:8042 B2I2B5 470 56.5 451 196 0 7 457 4 454 2e-177 503.0 0 0 0 0 0 0 0 0 0 0 Z1_01345 Rv0652_(rplL) PHI:7583 P9WHE3 1773 44.1 127 63 2 3 121 4 130 2e-18 73.6 0 0 0 0 0 0 0 0 0 0 Z1_00556 PafP PHI:4631 P19642 562 44.2 52 29 0 20 71 460 511 3.03e-06 47.8 0 0 0 0 0 0 0 0 0 0 Z1_03086 ArnT PHI:7953 A6TF96 573 47.5 535 275 5 5 536 2 533 3.0499999999999997e-175 504.0 0 0 0 0 0 0 0 0 0 0 Z1_03538 RSp0672 PHI:10834 Q3J038 305 43.6 218 121 1 3 220 13 228 3.07e-50 162.0 CAD17823 Ralstonia solanacearum OE1-1 Bacterial wilt Eudicots 4111 Solanum melongena (related: eggplant) Effector protein effector (plant avirulence determinant) Gene deletion: full Z1_01330 FkpA PHI:4583 C9Y236 413502 59.2 250 97 1 1 245 1 250 3.0899999999999996e-94 276.0 CBA34185 Cronobacter turicensis LMG 23827 Meningitis; bacteremia Primates 9606 Homo sapiens (related: human) virulence factor reduced virulence Gene mutation; gene complementation Z1_02318 RpfF PHI:8852 Q8PLC3 346 40.2 87 50 1 115 201 128 212 3.11e-12 66.2 0 0 0 0 0 0 0 0 0 0 Z1_01838 NlpD PHI:9369 Q7CKC8 632 46.0 385 145 6 1 374 1 333 3.1200000000000003e-97 291.0 0 0 0 0 0 0 0 0 0 0 Z1_03016 ZnuC PHI:11007 P0A9X1 562 74.7 237 60 0 1 237 1 237 3.13e-129 363.0 0 0 0 0 0 0 0 0 0 0 Z1_02734 HmuS PHI:7906 Q66FJ7 633 62.9 345 121 2 1 345 1 338 3.13e-151 427.0 0 0 0 0 0 0 0 0 0 0 Z1_00658 TamB PHI:10715 D4F0Q2 636 60.5 613 242 0 661 1273 13 625 3.1500000000000003e-257 743.0 0 0 0 0 0 0 0 0 0 0 Z1_01201 GlpD PHI:3272 Q8CWG4 632 79.0 496 102 2 1 496 29 522 3.15e-296 808.0 0 0 0 0 0 0 0 0 0 0 Z1_02459 MgtC PHI:3668__PHI:4693__PHI:4698__PHI:9435 D0ZLQ7 28901 62.4 229 84 1 1 229 5 231 3.15e-89 261.0 0 0 0 0 0 0 0 0 0 0 Z1_01523 STM14_RS15280 PHI:10069 A0A0F6B5R2 28901 52.1 167 78 2 1 167 1 165 3.18e-45 145.0 ACY89856 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) Formate hydrogenlyase subunit 5 unaffected pathogenicity Gene deletion: full Z1_03716 MprA PHI:5407__PHI:7646 P0ACR9 562 69.2 169 48 1 1 169 1 165 3.18e-76 224.0 0 0 0 0 0 0 0 0 0 0 Z1_02168 GalK PHI:6269 P0A6T3 562 64.1 370 133 0 12 381 11 380 3.19e-168 474.0 0 0 0 0 0 0 0 0 0 0 Z1_00806 TufA PHI:10282 W8TRT9 1280 76.1 393 94 0 1 393 1 393 3.2000000000000002e-226 621.0 0 0 0 0 0 0 0 0 0 0 Z1_01829 RaxP_(cysD) PHI:1138 B2SI03 347 68.0 297 95 0 6 302 6 302 3.21e-145 409.0 0 0 0 0 0 0 0 0 0 0 Z1_03737 YfiA PHI:3675__PHI:3681 D4HX89 552 68.9 103 32 0 1 103 1 103 3.21e-48 148.0 0 0 0 0 0 0 0 0 0 0 Z1_01839 RpoS PHI:10574 C6DDF7 554 80.5 329 62 2 1 327 1 329 3.22e-182 504.0 0 0 0 0 0 0 0 0 0 0 Z1_01810 MetP PHI:11570 R4ZAR0 1311 41.6 209 117 3 11 217 25 230 3.22e-40 135.0 0 0 0 0 0 0 0 0 0 0 Z1_01761 AmiC PHI:9372 A0A380PMR4 632 72.0 415 113 2 1 414 1 413 3.2400000000000006e-210 583.0 0 0 0 0 0 0 0 0 0 0 Z1_02038 AldA_(PSPTO_0092) PHI:7787 Q88BC5 317 40.7 477 276 5 18 489 21 495 3.27e-120 360.0 0 0 0 0 0 0 0 0 0 0 Z1_00754 YfiB PHI:7572 W9BJ64 573 59.2 512 198 2 1 508 1 505 3.2e-210 590.0 0 0 0 0 0 0 0 0 0 0 Z1_00490 STM14_RS15320 PHI:10077 A0A0F6B5S2 28901 53.8 93 36 3 1 90 1 89 3.32e-28 96.3 ACY89866 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) Hydrogenase formation protein unaffected pathogenicity Gene deletion: full Z1_00376 RsmI PHI:4960 A0A0H3JLK2 1280 47.1 221 116 1 14 234 4 223 3.33e-58 186.0 0 0 0 0 0 0 0 0 0 0 Z1_02731 HmuV PHI:7909 Q66FK0 633 59.6 255 103 0 9 263 11 265 3.34e-105 304.0 0 0 0 0 0 0 0 0 0 0 Z1_03419 TRR1 PHI:2846 Q5RZ66 5207 49.5 321 142 8 6 313 2 315 3.34e-95 284.0 AY796185 Cryptococcus neoformans H99 Lethal pathogen phenotype Lethal pathogen phenotype Lethal pathogen phenotype Thioredoxin reductase lethal Altered gene expression / gene regulation Z1_01309 XC_0481 PHI:3941 Q4UZG1 339 60.2 191 75 1 1 190 1 191 3.36e-81 238.0 AAY47562 Xanthomonas campestris pv. campestris strain 8004 Black rot Eudicots 3726 Raphanus sativus (related: radish) Anthranilate synthase component II reduced virulence Gene mutation Z1_02528 YebN PHI:7899 G1BJ13 347 50.5 190 91 2 1 187 1 190 3.38e-58 179.0 0 0 0 0 0 0 0 0 0 0 Z1_02700 BetL PHI:10583 C6DKY6 554 69.3 192 59 0 1 192 1 192 3.39e-91 263.0 0 0 0 0 0 0 0 0 0 0 Z1_01856 mC PHI:10209 A0A086ITU0 573 40.7 204 113 5 19 218 20 219 3.42e-50 161.0 0 0 0 0 0 0 0 0 0 0 Z1_00243 ClpX PHI:9833 Q8PBY5 339 75.8 422 98 2 5 423 8 428 3.4599999999999994e-225 621.0 0 0 0 0 0 0 0 0 0 0 Z1_01525 STM14_RS15270 PHI:10067 A0A0F6B5R0 28901 49.2 130 65 1 6 134 4 133 3.48e-40 129.0 ACY89854 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) NADH-quinone oxidoreductase subunit unaffected pathogenicity Gene deletion: full Z1_02757 STM14_RS07745_(pykF) PHI:10107 A0A0F6B0X2 28901 84.5 470 73 0 1 470 1 470 3.49e-280 764.0 0 0 0 0 0 0 0 0 0 0 Z1_01485 XC_3615 PHI:3957 Q4UQL6 339 46.7 122 64 1 190 311 194 314 3.5100000000000004e-27 106.0 AAY50657 Xanthomonas campestris pv. campestris strain 8004 Black rot Eudicots 3726 Raphanus sativus (related: radish) Electron transfer flavoprotein alpha subunit reduced virulence Gene mutation Z1_03075 AlsS PHI:8543 Q836A5 1351 47.4 544 279 3 9 551 5 542 3.5199999999999995e-170 492.0 AAO81010 Enterococcus faecalis JH2-2 Nosocomial infection Moths 7137 Galleria mellonella (related: greater wax moth) alpha-Acetolactate synthase reduced virulence Gene deletion: full Z1_02748 STM14_RS07715_(sufD) PHI:10101 A0A0F6B0W6 28901 51.5 412 194 5 24 432 10 418 3.51e-137 398.0 0 0 0 0 0 0 0 0 0 0 Z1_03428 MacA PHI:3929 E8XCP9 28901 56.4 360 155 1 7 364 6 365 3.5700000000000003e-125 363.0 ADX1663 Salmonella enterica subsp. enterica serovar Typhimurium strain ATCC 14028 Food poisoning; enteritis Rodents 10090 Mus musculus (related: house mouse) ABC-Type Efflux Pump reduced virulence Gene deletion Z1_02530 YeaB PHI:9496 A0A0H3NC59 28901 52.7 182 85 1 4 185 8 188 3.59e-60 184.0 0 0 0 0 0 0 0 0 0 0 Z1_02382 KatA PHI:10648 O52762 287 77.3 475 107 1 2 475 3 477 3.6000000000000004e-291 793.0 0 0 0 0 0 0 0 0 0 0 Z1_02292 AdeN PHI:7809 A3M2U3 470 51.6 669 314 5 7 671 8 670 3.6199999999999997e-230 654.0 0 0 0 0 0 0 0 0 0 0 Z1_00993 AroB PHI:4250 C5A9K4 337 55.2 344 152 2 1 344 1 342 3.61e-123 357.0 0 0 0 0 0 0 0 0 0 0 Z1_02172 IreA PHI:6654 Q93FB0 562 57.0 676 286 4 5 679 11 682 3.6299999999999996e-282 786.0 0 0 0 0 0 0 0 0 0 0 Z1_00168 XC_2466 PHI:3968 Q4UTV7 339 45.5 123 67 0 4 126 4 126 3.6500000000000003e-35 116.0 AAY49516 Xanthomonas campestris pv. campestris strain 8004 Black rot Eudicots 3726 Raphanus sativus (related: radish) Aspartate alpha-decarboxylase reduced virulence Gene mutation Z1_02675 AdhE PHI:8932 A0A116Q7Z1 1307 45.2 876 451 10 9 871 20 879 3.66e-251 723.0 0 0 0 0 0 0 0 0 0 0 Z1_01537 SerB_(BAB1_1410) PHI:11161 Q2YS30 29459 42.6 230 127 4 88 315 63 289 3.69e-44 151.0 0 0 0 0 0 0 0 0 0 0 Z1_02689 OppD_(bb0334) PHI:7820 H7C7Q3 139 47.0 279 145 2 9 284 6 284 3.7199999999999998e-81 246.0 0 0 0 0 0 0 0 0 0 0 Z1_02065 LeuA_(Dda3937_04301) PHI:8578 E0SG93 204038 74.0 524 131 1 1 519 1 524 3.72e-280 768.0 0 0 0 0 0 0 0 0 0 0 Z1_02746 SufB__STM14_RS07705_(sufB) PHI:6893__PHI:10099 A0A0F6B0W4 28901 80.6 495 92 3 5 498 4 495 3.72e-293 799.0 0 0 0 0 0 0 0 0 0 0 Z1_02541 PagP PHI:9385 A0A0H2YXJ2 562 51.6 161 76 2 53 212 26 185 3.76e-55 172.0 0 0 0 0 0 0 0 0 0 0 Z1_02837 CysB PHI:8764 G3XCU6 287 62.8 323 120 0 1 323 1 323 3.77e-143 405.0 0 0 0 0 0 0 0 0 0 0 Z1_00827 SoxR PHI:3092 H3RI38 66269 81.2 298 56 0 1 298 1 298 3.77e-178 492.0 EHT98951 Pantoea stewartii subsp. stewartii strain DC283 Stewart's wilt Monocots 4577 Zea mays (related: maize) activate gene expression in response to oxidative stress reduced virulence Gene mutation Z1_03459 PSPTO_2691 PHI:3118 Q882D7 317 45.1 246 133 1 1 244 5 250 3.77e-65 210.0 AAO56193 Pseudomonas syringae pv. tomato strain DC3000 Bacterial speck (tomato) Eudicots 4081 Solanum lycopersicum (related: tomato) Membrane protein, TerC family unaffected pathogenicity Gene mutation Z1_00792 RplN PHI:11120 Q7VTC1 520 74.0 123 31 1 1 123 1 122 3.78e-59 176.0 0 0 0 0 0 0 0 0 0 0 Z1_01821 PG0343 PHI:7938 Q7MX71 837 53.4 386 178 2 8 392 11 395 3.7e-150 429.0 AAQ65554 Porphyromonas gingivalis W83 Periodontitis Rodents 10090 Mus musculus (related: house mouse) L-methionine gamma-lyase reduced virulence Gene deletion: full Z1_02702 Bab2_0277 PHI:9126 Q2YIV2 235 40.9 531 304 7 3 531 5 527 3.8099999999999997e-115 350.0 0 0 0 0 0 0 0 0 0 0 Z1_01105 TfmR_(XAC3052) PHI:9118 Q8PI46 346 43.6 55 31 0 12 66 21 75 3.81e-07 47.4 0 0 0 0 0 0 0 0 0 0 Z1_00753 MoIlv2 PHI:3975 G4MMK2 318829 43.3 577 280 11 2 538 83 652 3.81e-147 437.0 EHA56980 Magnaporthe oryzae Guy11 Blast (rice) Monocots 4513 Hordeum vulgare (related: barley) Acetolactate synthases loss of pathogenicity Gene disruption; gene complementation Z1_01020 GidA PHI:11091 A4VYE0 1307 49.4 621 311 2 3 622 5 623 3.82e-203 582.0 0 0 0 0 0 0 0 0 0 0 Z1_00309 YedF PHI:7643 P0AA34 28901 94.7 76 4 0 5 80 2 77 3.83e-50 150.0 0 0 0 0 0 0 0 0 0 0 Z1_00199 CueO PHI:10985 P36649 562 61.6 526 190 4 1 524 1 516 3.87e-237 659.0 0 0 0 0 0 0 0 0 0 0 Z1_03237 NagZ PHI:3282 Q4USG7 339 43.0 279 156 2 4 280 2 279 3.87e-68 215.0 AAY50006 Xanthomonas campestris pv. campestris strain Xc17 Black rot Eudicots 3712 Brassica oleracea (no common name found) b-lactamase induction reduced virulence Gene disruption; gene complementation Z1_01846 PmpA PHI:10243 Q51917 584 100.0 183 0 0 1 183 1 183 3.88e-122 340.0 0 0 0 0 0 0 0 0 0 0 Z1_00994 DamX PHI:6729 P11557 562 50.0 100 47 1 217 313 329 428 3.89e-25 102.0 0 0 0 0 0 0 0 0 0 0 Z1_03174 GpT PHI:3319 B8F4F0 738 69.2 39 12 0 962 1000 785 823 3.96e-10 62.4 0 0 0 0 0 0 0 0 0 0 Z1_01882 PurT PHI:8653 P33221 562 69.4 385 118 0 1 385 1 385 3.98e-195 543.0 0 0 0 0 0 0 0 0 0 0 Z1_02670 Hnr PHI:2679 Q7CQF1 28901 40.2 336 198 2 1 334 1 335 3.98e-84 256.0 0 0 0 0 0 0 0 0 0 0 Z1_00252 QoxB PHI:4038 A6QFR9 1280 47.8 638 315 8 29 660 28 653 3.99e-203 584.0 0 0 0 0 0 0 0 0 0 0 Z1_02514 FliZ PHI:3922 N1NKQ7 628 85.1 168 25 0 1 168 1 168 3e-103 292.0 CCW30936 Xenorhabdus nematophila F1 Moths 7109 Spodoptera littoralis (related: african cotton leafworm) Global Regulatory Protein reduced virulence Gene mutation Z1_01216 EaAdeP_(EAMY_3685) PHI:10919 D4I4J9 552 78.7 432 92 0 13 444 6 437 3e-238 656.0 0 0 0 0 0 0 0 0 0 0 Z1_00510 MCC PHI:5068 I1S2C4 5518 40.1 459 269 5 5 461 637 1091 4.0199999999999996e-94 314.0 CEF86247 Fusarium graminearum Z-3639 Fusarium head blight Monocots 4565 Triticum aestivum (related: bread wheat) Encoding methylcrotonyl-CoA-carboxylase reduced virulence Gene mutation; gene complementation Z1_00339 NhaR PHI:3267 P0A9G2 562 76.8 297 69 0 1 297 1 297 4.02e-172 477.0 0 0 0 0 0 0 0 0 0 0 Z1_01310 ArgD PHI:3126__PHI:9305 D4I307 552 69.3 394 121 0 6 399 8 401 4.02e-202 561.0 0 0 0 0 0 0 0 0 0 0 Z1_00441 OadD PHI:8542 Q2KKC1 1351 41.0 61 36 0 95 155 72 132 4.03e-06 42.4 AAX97431 Enterococcus faecalis JH2-2 Nosocomial infection Primates 9606 Homo sapiens (related: human) Biotin acceptor protein reduced virulence Gene deletion: full Z1_01178 QsvR_(VPA0606) PHI:8742 Q87IK0 670 41.5 53 31 0 221 273 209 261 4.03e-07 48.5 0 0 0 0 0 0 0 0 0 0 Z1_01303 DsbA_(ROD_38991) PHI:8691 D2TUX9 67825 61.8 207 79 0 1 207 1 207 4.04e-92 266.0 0 0 0 0 0 0 0 0 0 0 Z1_02244 PXO_RS06935__PilR_(PXO_04881) PHI:9027__PHI:10487 A0A0K0GIH5 347 43.0 379 209 2 1 374 4 380 4.09e-93 287.0 0 0 0 0 0 0 0 0 0 0 Z1_02499 Flil PHI:6995 Q9I4N1 287 63.0 424 151 1 29 452 29 446 4.17e-176 499.0 AE004540_13 Pseudomonas aeruginosa PA14 Opportunistic infection Rodents 10090 Mus musculus (related: house mouse) Flagellin reduced virulence Gene mutation Z1_00422 YhbH PHI:3674__PHI:3680 D4HUY4 552 64.2 95 34 0 1 95 1 95 4.1999999999999997e-41 129.0 0 0 0 0 0 0 0 0 0 0 Z1_03002 FadD PHI:4108 A5F6S0 666 71.1 553 159 1 1 552 1 553 4.2200000000000003e-296 812.0 0 0 0 0 0 0 0 0 0 0 Z1_00624 NlpI PHI:2459 D4ICB6 552 79.4 296 58 3 1 295 1 294 4.29e-165 458.0 0 0 0 0 0 0 0 0 0 0 Z1_02248 FhpB PHI:3276 Q4WC12 746128 42.4 399 219 3 2 389 31 429 4.33e-106 318.0 0 0 0 0 0 0 0 0 0 0 Z1_03454 HisF_(A1S_3245) PHI:10701 A3M9P1 470 42.4 257 143 2 1 257 1 252 4.34e-68 209.0 0 0 0 0 0 0 0 0 0 0 Z1_02443 STM14_RS07790_(ttrR) PHI:10117 Q7CQM8 28901 63.9 83 30 0 1 83 1 83 4.3e-31 106.0 0 0 0 0 0 0 0 0 0 0 Z1_00870 CpxR PHI:8512__PHI:8688 D2TU76 67825 87.1 232 30 0 1 232 1 232 4.41e-143 397.0 0 0 0 0 0 0 0 0 0 0 Z1_03024 Hcp1 PHI:10597 C6DCT4 554 87.8 172 21 0 1 172 1 172 4.46e-118 329.0 0 0 0 0 0 0 0 0 0 0 Z1_01886 WzzfepE PHI:3727 E8X960 28901 40.6 345 198 2 28 369 26 366 4.47e-76 238.0 ADX16335 Salmonella enterica subsp. enterica serovar Typhimurium strain NCTC 12023 Food poisoning Moths 7137 Galleria mellonella (related: greater wax moth) Ferric enterobactin transport protein FepE loss of pathogenicity Gene mutation Z1_03661 MoDeam PHI:5472 G4NB53 318829 57.1 259 111 0 1 259 1 259 4.48e-109 318.0 EHA48815 Magnaporthe oryzae KJ201 Blast (rice) Monocots 4530 Oryza sativa (related: rice) GlcN-6-phosphate deaminase reduced virulence Gene deletion: full; gene complementation Z1_00134 C2515 PHI:11343 A0A0H2VAW4 562 63.5 255 90 1 7 261 2 253 4.4900000000000003e-110 316.0 0 0 0 0 0 0 0 0 0 0 Z1_03490 RhlE1_(PA3950)__RhlE2_(PA0428) PHI:11622__PHI:11623 Q9HX66 287 54.8 394 173 3 4 393 3 395 4.54e-139 405.0 0 0 0 0 0 0 0 0 0 0 Z1_01569 HopA1 PHI:3165 W0H866 36746 40.0 255 152 1 4 257 29 283 4.5799999999999997e-54 175.0 0 0 0 0 0 0 0 0 0 0 Z1_02066 LeuO PHI:7770 A0A0H6RQV7 666 48.8 295 148 2 19 312 20 312 4.57e-96 285.0 0 0 0 0 0 0 0 0 0 0 Z1_02019 KduD PHI:10587 A0A518VKX7 554 70.5 251 74 0 1 251 3 253 4.5e-125 353.0 0 0 0 0 0 0 0 0 0 0 Z1_00059 LssD PHI:4976 Q83XM0 446 42.9 375 194 8 50 419 19 378 4.6100000000000004e-86 265.0 CAD90950 Legionella pneumophila Paris Legionnaires' disease Eukaryotes 5755 Acanthamoeba castellanii (no common name found) Functional Type 1 Secretion System reduced virulence Gene disruption Z1_03711 ProV PHI:8968 A0A086IQC3 573 73.1 398 107 0 1 398 1 398 4.64e-210 581.0 0 0 0 0 0 0 0 0 0 0 Z1_01500 GroEL PHI:3085 P42375 837 61.8 526 200 1 3 527 2 527 4.64e-222 623.0 BAA04222 Porphyromonas gingivalis ATCC 33277 Periodontitis Rodents 10114 Rattus (related: rat) folding of newly synthesized proteins, preventing misfolding and aggregation increased virulence (hypervirulence) Functional test in host: direct injection Z1_00637 FtsH PHI:11203 Q6NF92 1717 45.8 616 310 7 6 602 5 615 4.66e-166 494.0 0 0 0 0 0 0 0 0 0 0 Z1_02470 CheY PHI:8732__PHI:10049 P0A2D5 28901 82.2 129 23 0 1 129 1 129 4.71e-72 209.0 0 0 0 0 0 0 0 0 0 0 Z1_03089 ArnC PHI:7950 A6TF99 573 76.1 314 75 0 1 314 1 314 4.72e-171 476.0 0 0 0 0 0 0 0 0 0 0 Z1_03280 MepS PHI:11093 P0AFV4 562 60.8 186 69 2 2 186 3 185 4.73e-74 220.0 AAC75236 Escherichia coli UTI89 Infection Rodents 10090 Mus musculus (related: house mouse) Peptidoglycan DD-endopeptidase/peptidoglycan LD-carboxypeptidase reduced virulence Gene deletion: full; gene complementation Z1_02460 FlhD PHI:4075 L0MK13 615 79.3 116 24 0 1 116 1 116 4.750000000000001e-59 176.0 0 0 0 0 0 0 0 0 0 0 Z1_00229 YmoA PHI:3819 P0A3X0 632 88.1 67 8 0 1 67 1 67 4.7e-39 121.0 0 0 0 0 0 0 0 0 0 0 Z1_02264 SseB PHI:3761 D0ZRW0 28901 40.9 115 65 1 17 131 142 253 4.8099999999999994e-23 89.4 0 0 0 0 0 0 0 0 0 0 Z1_00297 PhoR PHI:9434 Q8ZRE1 28901 62.4 428 161 0 1 428 1 428 4.8099999999999997e-197 550.0 0 0 0 0 0 0 0 0 0 0 Z1_02498 Filj PHI:6463 P0A1K1 28901 45.9 146 78 1 1 146 1 145 4.82e-33 112.0 0 0 0 0 0 0 0 0 0 0 Z1_01435 STM14_RS15395_(prgK) PHI:10092 A0A0F6B5T9 28901 43.8 233 112 6 1 225 1 222 4.8499999999999995e-45 150.0 0 0 0 0 0 0 0 0 0 0 Z1_00057 PotE PHI:9154 P0AAF1 562 82.8 429 74 0 15 443 7 435 4.8499999999999996e-256 701.0 0 0 0 0 0 0 0 0 0 0 Z1_02733 HmuT PHI:7907 Q66FJ8 633 55.2 268 119 1 5 271 10 277 4.84e-100 292.0 0 0 0 0 0 0 0 0 0 0 Z1_01202 YihW PHI:6545 Q9L7R1 28901 41.8 244 142 0 6 249 11 254 4.84e-72 219.0 0 0 0 0 0 0 0 0 0 0 Z1_03271 YeiE PHI:11609 Q8ZNK8 28901 64.1 287 102 1 1 287 1 286 4.86e-130 369.0 0 0 0 0 0 0 0 0 0 0 Z1_02862 FumC PHI:10048 Q8ZPL7 28901 83.6 463 76 0 1 463 1 463 4.87e-285 776.0 0 0 0 0 0 0 0 0 0 0 Z1_03373 ImpJ PHI:10596 A0A1M5U2L7 554 47.3 446 232 2 1 446 1 443 4.8999999999999995e-147 425.0 0 0 0 0 0 0 0 0 0 0 Z1_01452 BicA PHI:5323 A0A069B9Y9 28450 51.7 147 71 0 11 157 12 158 4.89e-52 162.0 0 0 0 0 0 0 0 0 0 0 Z1_01524 STM14_RS15275 PHI:10068 A0A0F6B5R1 28901 63.9 244 83 2 15 258 16 254 4.99e-113 323.0 ACY89855 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) Formate hydrogenlyase complex iron-sulfur subunit unaffected pathogenicity Gene deletion: full Z1_01003 ActP PHI:9229 P32705 562 80.3 532 104 1 20 551 19 549 4e-294 806.0 0 0 0 0 0 0 0 0 0 0 Z1_01428 VexB PHI:7771 A6P7G9 666 46.4 1008 529 2 1 1007 1 998 4e-311 887.0 0 0 0 0 0 0 0 0 0 0 Z1_02590 CjrC PHI:10794 C8CGJ2 562 44.7 745 404 6 9 749 13 753 5.0299999999999994e-216 624.0 0 0 0 0 0 0 0 0 0 0 Z1_02434 GzZC087 PHI:1772 I1S053 5518 46.3 54 28 1 105 158 587 639 5.03e-08 50.8 FGSG_10069 Fusarium graminearum GZ3639 Fusarium ear blight Monocots 4564 Triticum (related: wheat) transcription factor reduced virulence Gene deletion Z1_00311 STM14_RS15330 PHI:10079 A0A0F6B5S4 28901 66.0 335 114 0 5 339 2 336 5.05e-162 454.0 ACY89868 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) Formate hydrogenlyase transcriptional activator unaffected pathogenicity Gene deletion: full Z1_01720 MdsABC PHI:6553 Q54001 28901 63.7 452 161 1 1 452 3 451 5.09e-184 521.0 TOLC_SALEN Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Salmonellosis Rodents 10090 Mus musculus (related: house mouse) Multidrug transporter of Salmonella reduced virulence Gene mutation Z1_00929 MurQ PHI:7350 Q2FK71 1280 46.1 295 155 2 5 297 2 294 5.1199999999999994e-89 266.0 0 0 0 0 0 0 0 0 0 0 Z1_03379 VasK PHI:3979 Q0PZG0 644 42.9 1157 632 11 35 1182 25 1161 5.13e-312 900.0 0 0 0 0 0 0 0 0 0 0 Z1_01875 PA2537 PHI:3783 Q9I0U7 287 40.7 214 110 3 12 223 5 203 5.16e-51 163.0 AE004681_7 Pseudomonas aeruginosa PAO1 Infection Beetles 7067 Tenebrio molitor (related: yellow mealworm) acyltransferases reduced virulence Altered gene expression / gene regulation: overexpression Z1_01451 BsaZ PHI:5324 Q63K32 28450 40.0 340 203 1 1 339 1 340 5.16e-71 225.0 0 0 0 0 0 0 0 0 0 0 Z1_03402 AroA PHI:2624__PHI:6460__PHI:6586 P07637 28901 76.7 424 99 0 1 424 1 424 5.2100000000000004e-235 646.0 0 0 0 0 0 0 0 0 0 0 Z1_01444 InvC PHI:645__PHI:8301 P0A1B9 28901 52.6 416 195 1 6 421 11 424 5.22e-149 428.0 0 0 0 0 0 0 0 0 0 0 Z1_03224 PhoP PHI:7904 I3NI96 633 70.7 222 65 0 1 222 1 222 5.24e-117 331.0 0 0 0 0 0 0 0 0 0 0 Z1_02463 MotB PHI:6534 P0AF06 562 61.1 270 103 1 7 274 8 277 5.2599999999999994e-104 306.0 0 0 0 0 0 0 0 0 0 0 Z1_02255 IscR PHI:3043__PHI:7900 Q667Y0 633 80.5 164 30 2 1 163 1 163 5.27e-88 253.0 0 0 0 0 0 0 0 0 0 0 Z1_00846 MetJ PHI:2695 Q6CZA0 29471 91.4 105 9 0 1 105 1 105 5.28e-69 200.0 0 0 0 0 0 0 0 0 0 0 Z1_03551 SdhB PHI:7965 P07014 562 87.8 238 29 0 1 238 1 238 5.3100000000000005e-163 448.0 0 0 0 0 0 0 0 0 0 0 Z1_00605 FimH PHI:2690__PHI:7180__PHI:7204__PHI:7846__PHI:8107__PHI:9788__PHI:11259 P08191 562 47.0 287 144 4 25 310 21 300 5.31e-84 253.0 0 0 0 0 0 0 0 0 0 0 Z1_02166 GalE PHI:9264 P24325 727 61.0 336 131 0 1 336 1 336 5.33e-150 424.0 0 0 0 0 0 0 0 0 0 0 Z1_03751 LuxS PHI:3731 A1AEN2 562 84.2 171 27 0 1 171 1 171 5.34e-105 296.0 ABJ02122 Escherichia coli serotype O78:K80:H9 strain χ7122 Colibacillosis; cellulitis; swollen head syndrome Birds 9031 Gallus gallus (related: chicken) controller in the Quorum sensing reduced virulence Gene deletion; gene complementation Z1_02515 PutA PHI:7999 Q9I5F6 287 48.9 1051 484 14 92 1119 24 1044 5.34e-316 912.0 0 0 0 0 0 0 0 0 0 0 Z1_02189 Mqo PHI:6190 Q5HDJ0 1280 48.5 493 251 2 4 496 3 492 5.36e-170 487.0 AGY90568 Staphylococcus aureus Newman Skin infection; food poisoning; respiratory disease Rodents 10090 Mus musculus (related: house mouse) malate-quinone oxidoreductases reduced virulence Gene mutation Z1_01295 Glr1 PHI:4904 C4YR40 5476 49.0 482 209 11 3 449 36 515 5.38e-145 422.0 EEQ46193 Candida albicans Disseminated candidiasis Rodents 10090 Mus musculus (related: house mouse) Glutathione recycling enzymes/ glutathione reductase reduced virulence Gene disruption; gene complementation Z1_02257 IscU PHI:6892 A0A0L9JQ40 28901 89.8 128 13 0 1 128 1 128 5.38e-82 234.0 0 0 0 0 0 0 0 0 0 0 Z1_00901 RfaC PHI:9594 P26469 28901 70.5 312 92 0 3 314 2 313 5.3e-159 445.0 0 0 0 0 0 0 0 0 0 0 Z1_01241 GreB PHI:7131 Q8ZLJ2 28901 58.4 154 64 0 3 156 2 155 5.430000000000001e-57 174.0 0 0 0 0 0 0 0 0 0 0 Z1_03108 STM14_RS15355 PHI:10084 A0A0F6B5T0 28901 67.3 275 90 0 5 279 4 278 5.4799999999999996e-126 359.0 ACY89874 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) Iron ABC transporter permease unaffected pathogenicity Gene deletion: full Z1_01239 EnvZ PHI:2686 P08982 28901 52.7 440 208 0 1 440 1 440 5.490000000000001e-166 473.0 0 0 0 0 0 0 0 0 0 0 Z1_00665 BcPIC5__BcFKBP12 PHI:548__PHI:2305 Q2LK92 40559 43.5 115 53 2 103 205 2 116 5.49e-18 74.7 0 0 0 0 0 0 0 0 0 0 Z1_00353 RamA_(VK055_1983) PHI:7475 Q48413 573 50.0 102 51 0 6 107 7 108 5.51e-31 110.0 0 0 0 0 0 0 0 0 0 0 Z1_02098 PdhR PHI:3135 Q66EI1 633 81.5 254 47 0 6 259 1 254 5.56e-145 404.0 0 0 0 0 0 0 0 0 0 0 Z1_02791 PspC PHI:7659 A0A0F6B1W9 28901 48.2 114 58 1 5 118 7 119 5.56e-31 105.0 0 0 0 0 0 0 0 0 0 0 Z1_02465 CheW PHI:6536 P0A964 562 82.5 154 27 0 8 161 9 162 5.5e-82 238.0 0 0 0 0 0 0 0 0 0 0 Z1_02751 STM14_RS07730_(ynhG) PHI:10104 A0A0F6B0W9 28901 50.0 300 146 2 5 304 9 304 5.6199999999999997e-98 290.0 0 0 0 0 0 0 0 0 0 0 Z1_03487 SseA PHI:609__PHI:616 Q8Z4N6 28901 43.8 276 152 2 5 279 5 278 5.64e-79 239.0 0 0 0 0 0 0 0 0 0 0 Z1_02690 OppF_(bb0335) PHI:7821 H7C7L2 139 48.3 286 141 3 9 289 5 288 5.64e-85 258.0 0 0 0 0 0 0 0 0 0 0 Z1_02747 STM14_RS07710_(sufC) PHI:10100 A0A0F6B0W5 28901 81.9 248 45 0 1 248 1 248 5.65e-147 409.0 0 0 0 0 0 0 0 0 0 0 Z1_03299 CspA PHI:7637 P0A355 1639 68.9 61 18 1 7 67 4 63 5.65e-25 86.3 CAA62903 Listeria monocytogenes EGD-e Listeriosis Bony fishes 7955 Danio rerio (related: zebrafish) Cold shock protein reduced virulence Gene mutation Z1_00312 STM14_RS15325 PHI:10078 A0A0F6B5S3 28901 65.9 375 122 1 1 375 1 369 5.6600000000000005e-192 533.0 ACY89867 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) Hydrogenase expression/formation protein unaffected pathogenicity Gene deletion: full Z1_01834 XAC1722 PHI:4145 Q8PLR7 346 52.6 154 73 0 1 154 5 158 5.749999999999999e-54 166.0 AAM36589 Xanthomonas citri subsp. citri Canker (citrus) Eudicots 2711 Citrus sinensis (related: sweet orange) 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase reduced virulence Gene mutation Z1_02623 Orf408 PHI:612 H9L428 28901 48.9 395 198 1 2 392 3 397 5.75e-114 337.0 0 0 0 0 0 0 0 0 0 0 Z1_02444 TtrS PHI:605 Q83T39 28901 53.4 575 265 3 10 582 4 577 5.7e-205 583.0 0 0 0 0 0 0 0 0 0 0 Z1_02456 CspC PHI:7262 P0A9Y9 28901 89.6 67 7 0 4 70 3 69 5.84e-41 126.0 0 0 0 0 0 0 0 0 0 0 Z1_02068 FruR PHI:2672 P0A2P8 28901 83.2 334 56 0 1 334 1 334 5.85e-206 565.0 0 0 0 0 0 0 0 0 0 0 Z1_03480 Dps_(atu2477) PHI:10828 Q8UCK6 358 55.8 154 65 1 17 167 6 159 5.9199999999999996e-55 169.0 0 0 0 0 0 0 0 0 0 0 Z1_02123 UbiI PHI:7028 P25535 562 65.3 404 133 2 1 401 1 400 5.93e-195 543.0 0 0 0 0 0 0 0 0 0 0 Z1_03500 Rv3111 PHI:7748 P9WJR9 1773 56.4 156 67 1 4 159 8 162 5.93e-47 149.0 0 0 0 0 0 0 0 0 0 0 Z1_00491 STM14_RS15310 PHI:10075 A0A0F6B5S0 28901 53.5 114 52 1 1 113 1 114 5.95e-41 130.0 ACY89864 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) Hydrogenase nickel incorporation protein unaffected pathogenicity Gene deletion: full Z1_00667 AdcA PHI:9798 Q9A0L9 1314 47.2 178 91 2 41 215 338 515 5.95e-47 160.0 0 0 0 0 0 0 0 0 0 0 Z1_02158 STM14_RS15340 PHI:10081 A0A0F6B5S6 28901 67.9 109 33 1 1 107 1 109 5.95e-50 152.0 ACY89870 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) Iron ABC transporter substrate-binding protein unaffected pathogenicity Gene deletion: full Z1_02775 RovA PHI:6114 P69988 632 77.9 140 31 0 1 140 1 140 5.95e-70 205.0 AAM85527 Yersinia pestis 201 Plague Rodents 10090 Mus musculus (related: house mouse) MarR-family regulator reduced virulence Gene deletion: full Z1_03718 B0754 PHI:11544 C0RLS8 29459 57.6 420 168 3 4 413 72 491 5.96e-149 430.0 ACO02561 Brucella melitensis M28 Brucellosis Rodents 10090 Mus musculus (related: house mouse) ABC transporter substrate-binding protein unaffected pathogenicity Gene deletion: full; gene complementation Z1_01727 SufI PHI:10978 A7ZRQ3 562 59.0 471 190 3 1 471 1 468 5.98e-209 584.0 0 0 0 0 0 0 0 0 0 0 Z1_02766 SodB PHI:11377 P0A2F4 28901 80.2 192 38 0 1 192 1 192 5.99e-117 328.0 0 0 0 0 0 0 0 0 0 0 Z1_03553 SdhD PHI:7963 P0AC44 562 69.6 115 34 1 1 114 1 115 5.9e-50 152.0 0 0 0 0 0 0 0 0 0 0 Z1_00403 DegQ_(Dda3937_00697) PHI:8575 E0SHD8 204038 72.2 457 124 3 4 459 2 456 6.03e-222 616.0 0 0 0 0 0 0 0 0 0 0 Z1_01594 DsbC PHI:11406 A6GV51 573 46.7 199 106 0 30 228 34 232 6.050000000000001e-70 212.0 0 0 0 0 0 0 0 0 0 0 Z1_02472 FlhB PHI:11174 P76299 562 56.5 382 164 2 1 381 1 381 6.06e-142 407.0 0 0 0 0 0 0 0 0 0 0 Z1_00611 FimA PHI:9888 Q0SXL9 562 54.5 189 78 2 1 188 1 182 6.11e-57 176.0 0 0 0 0 0 0 0 0 0 0 Z1_02074 MurF PHI:7632 Q9HVZ7 287 43.9 433 230 9 29 454 24 450 6.14e-101 308.0 0 0 0 0 0 0 0 0 0 0 Z1_03225 PhoQ PHI:4899__PHI:6318__PHI:7356 D0ZV89 28901 54.4 480 217 2 8 487 10 487 6.14e-180 511.0 0 0 0 0 0 0 0 0 0 0 Z1_03427 MacB PHI:3928 Q8ZQE4 28901 63.8 654 224 2 1 647 1 648 6.16e-281 781.0 AAL19878 Salmonella enterica subsp. enterica serovar Typhimurium strain ATCC 14028 Food poisoning; enteritis Rodents 10090 Mus musculus (related: house mouse) ABC-Type Efflux Pump reduced virulence Gene deletion Z1_00500 NarJ PHI:10514 P0AF26 562 58.0 231 96 1 2 232 1 230 6.25e-88 258.0 0 0 0 0 0 0 0 0 0 0 Z1_00328 Bbakr1_(XP_008600433.1) PHI:9444 J4VZT4 176275 44.9 274 142 4 1 267 31 302 6.27e-73 224.0 0 0 0 0 0 0 0 0 0 0 Z1_02762 CFAS PHI:2643 A4HTK3 5671 49.5 386 171 6 17 378 96 481 6.2e-127 372.0 CAM65755 Leishmania infantum JPCM5 Leishmaniasis Rodents 10090 Mus musculus (related: house mouse) Cyclopropane fatty acid synthetase reduced virulence Gene deletion: full; gene complementation Z1_00285 GGT PHI:3146 O25743 210 48.1 538 277 2 15 551 20 556 6.31e-177 511.0 AAD08162 Helicobacter pylori G27 Gastric infection Moths 7137 Galleria mellonella (related: greater wax moth) virulence determinants unaffected pathogenicity Gene mutation Z1_00530 TatC PHI:8726 Q7CPD5 28901 71.7 258 73 0 1 258 1 258 6.39e-129 364.0 0 0 0 0 0 0 0 0 0 0 Z1_00660 MsrA1 PHI:4579 P0A082 1280 42.7 157 87 1 38 194 2 155 6.3e-35 120.0 0 0 0 0 0 0 0 0 0 0 Z1_02345 PA4841 PHI:10782 Q9HUW9 287 42.4 158 89 2 10 165 10 167 6.43e-36 121.0 AE004897_4 Pseudomonas aeruginosa PAO1161 Infection Nematodes 6239 Caenorhabditis elegans (related: roundworm) Nudix hydrolase domain-containing protein unaffected pathogenicity Gene deletion: full; gene complementation Z1_00845 MetB PHI:9314 D4HUF7 552 69.2 386 119 0 1 386 1 386 6.44e-194 539.0 0 0 0 0 0 0 0 0 0 0 Z1_01805 NlpE PHI:8514 D2TI83 67825 40.3 233 123 5 3 220 2 233 6.44e-49 158.0 0 0 0 0 0 0 0 0 0 0 Z1_03056 PrfA_(lmo2543) PHI:9821 Q8Y4A8 1639 51.1 354 169 2 8 358 4 356 6.48e-120 349.0 0 0 0 0 0 0 0 0 0 0 Z1_00769 DprA PHI:11059 Q8DPI7 1313 41.2 204 119 1 76 279 75 277 6.5e-47 160.0 0 0 0 0 0 0 0 0 0 0 Z1_01098 PdeB PHI:8643 D4I3P5 552 47.1 51 23 1 76 126 466 512 6.66e-07 47.4 0 0 0 0 0 0 0 0 0 0 Z1_03235 Ndh PHI:11248 A0A069PYL4 287 57.6 436 176 4 5 435 4 435 6.66e-168 477.0 0 0 0 0 0 0 0 0 0 0 Z1_03085 ArnE PHI:7954 A6TF95 573 50.0 100 48 1 10 109 11 108 6.68e-27 94.4 0 0 0 0 0 0 0 0 0 0 Z1_03248 Acp1_(PA1869) PHI:8556 O52658 287 50.0 76 38 0 1 76 1 76 6.69e-19 71.6 0 0 0 0 0 0 0 0 0 0 Z1_00020 NqrD_(PA2996) PHI:8942 Q9HZK9 287 70.5 207 61 0 1 207 2 208 6.74e-100 287.0 0 0 0 0 0 0 0 0 0 0 Z1_02732 HmuU PHI:7908 Q66FJ9 633 67.4 322 105 0 7 328 7 328 6.75e-144 408.0 0 0 0 0 0 0 0 0 0 0 Z1_02743 YbdB PHI:6270 Q8XBU9 562 61.0 136 53 0 1 136 1 136 6.76e-55 167.0 0 0 0 0 0 0 0 0 0 0 Z1_01290 Ypo3991 PHI:4189 Q7CG15 632 49.2 476 240 2 1 475 1 475 6.8300000000000005e-161 464.0 0 0 0 0 0 0 0 0 0 0 Z1_01837 Pimt PHI:6187 Q8ZMF9 28901 63.9 208 75 0 1 208 1 208 6.84e-96 276.0 0 0 0 0 0 0 0 0 0 0 Z1_00424 HpaP_(XC_1307) PHI:7824 Q4UX47 339 47.6 271 137 3 4 270 1 270 6.87e-84 251.0 0 0 0 0 0 0 0 0 0 0 Z1_00386 UreA PHI:7264 P14916 210 61.0 100 38 1 1 99 1 100 6.89e-35 117.0 BAA84532 Helicobacter pylori X47 Gastric infection Rodents 10090 Mus musculus (related: house mouse) Hydrolase reduced virulence Gene mutation Z1_01431 OxyR PHI:3091 H3RJ93 66269 55.0 149 67 0 1 149 1 149 6.910000000000001e-56 171.0 EHT98350 Pantoea stewartii subsp. stewartii strain DC283 Stewart's wilt Monocots 4577 Zea mays (related: maize) activate gene expression in response to oxidative stress unaffected pathogenicity Gene mutation Z1_01746 PA0336_(RppH) PHI:7474 Q9X4P2 287 66.0 153 52 0 1 153 1 153 6.91e-79 230.0 0 0 0 0 0 0 0 0 0 0 Z1_02393 RcsB_(YE1397) PHI:10469 A1JLB7 630 92.0 213 17 0 1 213 1 213 6.9499999999999995e-137 380.0 0 0 0 0 0 0 0 0 0 0 Z1_01895 CopA PHI:5275 B7VKI8 212663 46.6 915 457 8 75 982 62 951 6.949999999999999e-258 747.0 0 0 0 0 0 0 0 0 0 0 Z1_02006 FbaA PHI:6903 P99075 1280 40.9 279 160 2 1 276 1 277 6.950000000000001e-66 206.0 BAB43211 Staphylococcus aureus USA300 JE2 White muscardine Moths 7137 Galleria mellonella (related: greater wax moth) Fructose-bisphosphate aldolase reduced virulence Functional test in host: direct injection Z1_03264 PccS1_004012 PHI:10584 C6D9H7 554 41.0 83 49 0 1 83 1 83 6.96e-16 70.1 ACT13704 Pectobacterium carotovorum subsp. carotovorum strain PccS1 Soft rot Monocots 69721 Zantedeschia aethiopica (related: arum-lily) LysR family transcriptional regulator, partial unaffected pathogenicity Gene deletion: full; gene complementation Z1_03087 ArnD PHI:7952 A6TF97 573 62.7 295 109 1 1 295 1 294 6.97e-138 390.0 0 0 0 0 0 0 0 0 0 0 Z1_00666 Sdh1 PHI:3914 Q0V515 13684 52.8 483 219 3 2 481 7 483 6.98e-174 496.0 EAT92394 Parastagonospora nodorum SN15 Stagonospora nodorum blotch Monocots 4565 Triticum aestivum (related: bread wheat) encodes succinic semialdehyde dehydrogenase reduced virulence Gene disruption; gene complementation Z1_00782 SecY PHI:5257 Q8Y448 1639 42.9 427 230 7 16 434 11 431 7.01e-108 324.0 0 0 0 0 0 0 0 0 0 0 Z1_02096 PilA PHI:6362 A0A0U1YU94 553 45.7 138 74 1 9 145 3 140 7.01e-36 119.0 0 0 0 0 0 0 0 0 0 0 Z1_02467 McpB PHI:6985 A0A0F6B6S3 28901 49.4 241 121 1 190 430 186 425 7.04e-38 145.0 0 0 0 0 0 0 0 0 0 0 Z1_01479 HK2_(BB0763) PHI:10875 A0A0H3LHY6 139 40.0 250 141 6 13 261 19 260 7.04e-50 163.0 0 0 0 0 0 0 0 0 0 0 Z1_01302 RdoA_(ROD_39001) PHI:8692 D2TUY0 67825 52.5 326 153 2 6 331 5 328 7.05e-127 364.0 0 0 0 0 0 0 0 0 0 0 Z1_01323 Cj1564 PHI:4052 Q0P864 197 58.1 62 26 0 353 414 525 586 7.05e-14 72.8 CAL35661 Campylobacter jejuni NCTC 11168-O Gastroenteritis Birds 9031 Gallus gallus (related: chicken) Chemoreceptor unaffected pathogenicity Gene mutation; gene complementation Z1_00718 Cya PHI:9840 Q9KVL9 666 53.2 838 379 10 1 832 1 831 7.05e-314 881.0 0 0 0 0 0 0 0 0 0 0 Z1_02115 YbtP PHI:6912 A0A086VCI7 562 42.0 317 181 3 387 702 233 547 7.139999999999999e-68 231.0 0 0 0 0 0 0 0 0 0 0 Z1_03677 YbeY PHI:7671 A1JQ74 630 79.4 155 32 0 1 155 1 155 7.13e-89 254.0 0 0 0 0 0 0 0 0 0 0 Z1_02102 RtxA1 PHI:6878__PHI:8498 F1CLH1 672 53.7 162 75 0 3313 3474 1394 1555 7.189999999999999e-48 189.0 0 0 0 0 0 0 0 0 0 0 Z1_01660 Pyk__PykM_(BAB1_1761) PHI:6684__PHI:9762 Q2YRY5 235__29459 40.1 424 235 7 2 420 5 414 7.18e-81 257.0 0 0 0 0 0 0 0 0 0 0 Z1_03687 Ctp_(NMB0788) PHI:8622 Q9K034 487 42.1 107 62 0 99 205 90 196 7.23e-19 80.1 0 0 0 0 0 0 0 0 0 0 Z1_02363 NOS1 PHI:445 I1RA52 5518 42.6 385 215 2 217 598 87 468 7.24e-106 325.0 FG00376 Fusarium graminearum PH-1 Fusarium ear blight Monocots 4565 Triticum aestivum (related: bread wheat) Ubiquinone oxidoreductase reduced virulence Gene disruption Z1_01360 HupA PHI:3074 D0Z9U0 636 74.4 90 23 0 1 90 1 90 7.259999999999999e-42 130.0 0 0 0 0 0 0 0 0 0 0 Z1_03451 HisB PHI:7790 G7TE30 347 50.7 373 161 3 5 355 4 375 7.25e-132 380.0 AEQ96355 Xanthomonas oryzae pv. oryzicola strain RS105 Bacterial blight (rice) Monocots 4530 Oryza sativa (related: rice) Bifunctional enzyme implicated in the imidazoleglycerol-phosphate dehydratase activity reduced virulence Gene deletion: full; gene complementation Z1_00341 DnaJ PHI:10485 Q9HV44 287 59.2 380 148 3 1 376 1 377 7.25e-136 391.0 0 0 0 0 0 0 0 0 0 0 Z1_02431 PmrA PHI:3599 Q83CA1 777 40.3 221 130 1 1 219 10 230 7.33e-55 173.0 AAO90736 Coxiella burnetii Nine Mile Phase I Q fever Primates 9606 Homo sapiens (related: human) Response Regulator reduced virulence Gene mutation; gene complementation Z1_02341 PurF PHI:9317 D4HXG4 552 82.2 505 90 0 1 505 1 505 7.35e-309 840.0 0 0 0 0 0 0 0 0 0 0 Z1_03231 VraD PHI:6579 A0A0H3JS81 1280 43.6 204 115 0 24 227 20 223 7.389999999999999e-52 167.0 BAB43798 Staphylococcus aureus JE2 Skin infection; food poisoning; respiratory disease Moths 7137 Galleria mellonella (related: greater wax moth) Involved in Gallidermin and Daptomycin Resistance reduced virulence Gene mutation; gene complementation Z1_00698 mA PHI:10207 A0A0S3FFR9 573 40.4 156 82 5 25 172 40 192 7.38e-22 85.9 0 0 0 0 0 0 0 0 0 0 Z1_01514 EF-P PHI:6420 P64036 28901 84.6 188 29 0 1 188 1 188 7.4e-118 330.0 AAL23157 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Salmonellosis Rodents 10090 Mus musculus (related: house mouse) Elongation factor increased virulence (hypervirulence) Altered gene expression / gene regulation: downregulation Z1_03322 OmpA2 PHI:4160 B5XY48 573 69.3 361 97 4 1 360 1 348 7.51e-171 478.0 ACI08342 Klebsiella pneumoniae 52.145 Pneumonia Moths 7137 Galleria mellonella (related: greater wax moth) outer membrane proteins reduced virulence Gene mutation Z1_03425 ClpS PHI:8568 E0SMW8 204038 64.9 97 34 0 8 104 10 106 7.51e-44 136.0 0 0 0 0 0 0 0 0 0 0 Z1_01111 XOC_2335 PHI:6224 G7TEV4 347 45.1 206 111 2 13 216 438 643 7.51e-51 174.0 AEQ96469 Xanthomonas oryzae pv. oryzicola strain RS105 Bacterial blight (rice) Monocots 4530 Oryza sativa (related: rice) GGDEF-EAL domain proteins reduced virulence Gene mutation; gene complementation Z1_00589 ArgF PHI:2634 A0A0H2XHH2 1280 62.2 331 123 2 1 330 1 330 7.55e-143 405.0 0 0 0 0 0 0 0 0 0 0 Z1_00019 NqrE_(PA2995) PHI:8941 Q9HZL0 287 69.8 202 57 1 1 198 1 202 7.61e-96 275.0 0 0 0 0 0 0 0 0 0 0 Z1_03166 YadA PHI:7901 P10858 633 65.4 78 25 1 691 768 357 432 7.65e-22 97.4 CAF25356 Yersinia pseudotuberculosis IP2666 Zoonotic infection Even-toed ungulates 9940 Ovis aries (related: sheep) Adhesin unaffected pathogenicity Gene mutation Z1_02360 RovM PHI:5089 Q7CJ94 632 69.2 286 88 0 1 286 1 286 7.74e-137 388.0 AE013766_1 Yersinia pestis KIM6+ Bubonic plague Fleas 163159 Xenopsylla cheopis (related: oriental rat flea) LysR-Type Transcriptional Regulator reduced virulence Gene deletion: full; gene complementation Z1_00284 TsaA PHI:11384 A0A0H3NDI1 28901 79.0 200 42 0 1 200 1 200 7.76e-119 333.0 0 0 0 0 0 0 0 0 0 0 Z1_00895 EnvC PHI:5573 A0A0D6I3U0 28901 50.7 418 200 2 13 430 16 427 7.850000000000001e-109 326.0 0 0 0 0 0 0 0 0 0 0 Z1_00543 MetR PHI:9326 D4HUM6 552 71.7 297 84 0 1 297 1 297 7.860000000000001e-157 439.0 0 0 0 0 0 0 0 0 0 0 Z1_01410 FVEG_12529 PHI:3385 W7MS09 117187 53.6 422 195 1 4 424 10 431 7.87e-161 458.0 EWG54273 Fusarium verticillioides M-3125 Ear rot (maize); stalk rot (maize) Monocots 4577 Zea mays (related: maize) fusaric acid biosynthesis unaffected pathogenicity Gene deletion: full Z1_00149 Eno PHI:11234 A4VWH9 1307 54.5 431 186 5 1 426 1 426 7.929999999999999e-146 421.0 ABP90468 Streptococcus suis CVCC606 Meningitis; septicemia; arthritis; pneumonia (pig) Rodents 10090 Mus musculus (related: house mouse) Enolase unaffected pathogenicity Functional test in host Z1_02229 BglB PHI:11438 P0C0B9 1314 45.0 291 156 4 9 297 5 293 7.92e-81 245.0 0 0 0 0 0 0 0 0 0 0 Z1_02819 TrpB PHI:9321 D4I3E6 552 83.6 396 65 0 1 396 1 396 7.960000000000001e-251 684.0 0 0 0 0 0 0 0 0 0 0 Z1_01336 GzOB039 PHI:1599 I1RZ39 5518 57.6 125 50 2 2 123 53 177 7.96e-43 137.0 FGSG_09662 Fusarium graminearum GZ3639 Fusarium ear blight Monocots 4564 Triticum (related: wheat) transcription factor unaffected pathogenicity Gene deletion Z1_01825 CysJ_(Dda3937_00209) PHI:8574 E0SDK2 204038 59.8 602 231 2 10 604 10 607 7.97e-253 706.0 0 0 0 0 0 0 0 0 0 0 Z1_00985 PA5176 PHI:10783 Q9HU13 287 42.8 180 100 2 5 181 3 182 7.97e-48 152.0 AE004930_7 Pseudomonas aeruginosa PAO1161 Infection Nematodes 6239 Caenorhabditis elegans (related: roundworm) Nudix hydrolase domain-containing protein reduced virulence Gene deletion: full; gene complementation Z1_02627 GLPX__GPM2 PHI:6486__PHI:6487 P9WN21 1773 42.0 319 171 2 7 324 33 338 7.9800000000000005e-75 233.0 0 0 0 0 0 0 0 0 0 0 Z1_01300 MobA PHI:5304 Q4QM57 727 43.2 183 102 2 6 186 5 187 7.98e-46 148.0 0 0 0 0 0 0 0 0 0 0 Z1_03426 CspA_(WP_011258294.1) PHI:8636 A0A0U2P760 347 50.8 63 30 1 2 64 7 68 8.06e-21 75.9 0 0 0 0 0 0 0 0 0 0 Z1_01249 GlnA PHI:7742 P0A1P6 28901 82.7 468 81 0 1 468 1 468 8.12e-297 806.0 0 0 0 0 0 0 0 0 0 0 Z1_01516 STM14_RS15300 PHI:10073 A0A0F6B5R6 28901 55.4 184 78 2 1 184 1 180 8.21e-69 207.0 ACY89860 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) Formate hydrogenlyase regulator unaffected pathogenicity Gene deletion: full Z1_01784 Map PHI:9334 D2TI55 67825 77.4 265 58 1 1 265 1 263 8.26e-155 430.0 0 0 0 0 0 0 0 0 0 0 Z1_00320 HybO PHI:10996 P69741 562 79.3 368 75 1 1 368 1 367 8.350000000000001e-223 611.0 0 0 0 0 0 0 0 0 0 0 Z1_01023 AtpB PHI:9436 A0A0F6B941 28901 80.1 272 51 2 4 274 2 271 8.36e-152 423.0 0 0 0 0 0 0 0 0 0 0 Z1_02735 HmuR PHI:7905 Q66FJ6 633 55.5 650 279 5 33 680 35 676 8.41e-265 742.0 0 0 0 0 0 0 0 0 0 0 Z1_03415 RarA PHI:6447 A0A164J6A6 573 85.5 447 65 0 9 455 1 447 8.43e-279 759.0 0 0 0 0 0 0 0 0 0 0 Z1_01402 PotD PHI:11189 B8F6H2 738 53.1 337 158 0 11 347 13 349 8.45e-130 373.0 0 0 0 0 0 0 0 0 0 0 Z1_02587 CjrA PHI:10792 A0A061L181 562 48.0 248 129 0 35 282 35 282 8.48e-78 236.0 0 0 0 0 0 0 0 0 0 0 Z1_00035 GshB PHI:9281 Q9I697 287 62.6 313 116 1 2 314 3 314 8.51e-139 394.0 0 0 0 0 0 0 0 0 0 0 Z1_00018 NqrF_(PA2994)__NqrF PHI:8940__PHI:11246 Q9HZL1 287 68.7 403 123 2 6 408 8 407 8.51e-217 598.0 0 0 0 0 0 0 0 0 0 0 Z1_02653 STM14_RS15250 PHI:10063 A0A0F6B5Q4 28901 54.7 762 315 9 3 763 7 739 8.570000000000001e-257 728.0 ACY89848 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) Electron transport protein unaffected pathogenicity Gene deletion: full Z1_02076 MurD PHI:7631 Q9HVZ9 287 48.6 440 209 6 10 435 11 447 8.59e-118 350.0 0 0 0 0 0 0 0 0 0 0 Z1_03449 HisD_(PXO_00833) PHI:9983 A0A0K0GKU8 347 50.4 415 201 2 24 434 18 431 8.700000000000001e-133 387.0 0 0 0 0 0 0 0 0 0 0 Z1_00006 ProA PHI:11263 A5ICA4 446 40.8 412 237 4 7 416 10 416 8.75e-102 307.0 0 0 0 0 0 0 0 0 0 0 Z1_02211 SmpB PHI:4218 A1AEE9 562 85.0 160 24 0 1 160 1 160 8.78e-101 285.0 0 0 0 0 0 0 0 0 0 0 Z1_03247 PKS9__KSA1 PHI:724__PHI:730 I1RSU2 5518 45.9 427 211 7 4 412 2 426 8.78e-120 353.0 0 0 0 0 0 0 0 0 0 0 Z1_02450 PyrC PHI:9307 D4I0W8 552 68.4 348 108 1 3 348 2 349 8.7e-181 503.0 0 0 0 0 0 0 0 0 0 0 Z1_03107 STM14_RS15350 PHI:10083 A0A0F6B5S9 28901 65.0 266 84 1 10 275 6 262 8.82e-120 343.0 ACY89873 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) Iron ABC transporter permease unaffected pathogenicity Gene deletion: full Z1_00222 RsmS_(ECA1172) PHI:8933 Q6D803 29471 54.5 44 20 0 1 44 1 44 8.83e-11 49.3 0 0 0 0 0 0 0 0 0 0 Z1_00678 PurA PHI:2625__PHI:9416 P65882 28901 85.2 432 64 0 1 432 1 432 8.83e-280 760.0 0 0 0 0 0 0 0 0 0 0 Z1_00331 CarA_(Dda3937_01390) PHI:8577 E0SH08 204038 84.9 378 57 0 1 378 1 378 8.859999999999999e-242 660.0 0 0 0 0 0 0 0 0 0 0 Z1_00828 ArgH PHI:2632 Q2FIB5 1280 47.8 454 236 1 4 457 6 458 8.85e-143 415.0 0 0 0 0 0 0 0 0 0 0 Z1_01187 MGA_0220 PHI:7715 Q7NAX1 2096 44.4 108 60 0 147 254 222 329 8.949999999999999e-23 95.1 AAP56864 Mycoplasma gallisepticum Ap3AS Airsacculitis Birds 9031 Gallus gallus (related: chicken) Oligopeptide transporter ATP-binding protein OppD1 reduced virulence Gene deletion: full; gene complementation Z1_02314 VacJ PHI:6900 B8F8P8 738 46.4 248 129 3 2 247 3 248 9.010000000000001e-72 218.0 0 0 0 0 0 0 0 0 0 0 Z1_03690 LptE PHI:10313 P0ADC1 562 52.2 159 74 1 1 157 1 159 9.01e-50 157.0 BAA35288 Escherichia coli KP7600 Urinary tract infection Moths 7091 Bombyx mori (related: domestic silkworm) LPS-assembly protein increased virulence (hypervirulence) Gene mutation Z1_00162 DksA PHI:6508 P0A1G5 28901 94.7 151 8 0 1 151 1 151 9.02e-101 284.0 AAD01437 Salmonella enterica subsp. enterica serovar Typhimurium Salmonellosis Rodents 10090 Mus musculus (related: house mouse) Response Regulator reduced virulence Gene mutation; gene complementation Z1_01726 MrLPAAT1 PHI:6380 E9F1A7 568076 41.8 165 90 4 66 225 102 265 9.02e-29 108.0 0 0 0 0 0 0 0 0 0 0 Z1_00421 RpoN PHI:2906__PHI:3673__PHI:3679 D4HUY5 552 69.5 491 136 1 1 491 1 477 9.069999999999999e-234 648.0 0 0 0 0 0 0 0 0 0 0 Z1_01448 SpaP PHI:5325 A0A0H3HVR2 28450 58.3 223 85 1 2 216 3 225 9.08e-82 241.0 0 0 0 0 0 0 0 0 0 0 Z1_02966 FNR__Fnr PHI:4876__PHI:7248 P0A9E5 562 93.9 244 15 0 1 244 1 244 9.090000000000001e-166 456.0 0 0 0 0 0 0 0 0 0 0 Z1_01830 RaxQ PHI:1139 B2SI02 347 48.8 402 202 3 43 444 1 398 9.190000000000001e-129 385.0 0 0 0 0 0 0 0 0 0 0 Z1_02487 FlgK PHI:6360 A0A0U1YUA0 553 42.6 544 308 3 5 546 4 545 9.21e-139 411.0 0 0 0 0 0 0 0 0 0 0 Z1_01518 STM14_RS15290 PHI:10071 A0A0F6B5R4 28901 57.0 298 127 1 15 311 5 302 9.309999999999999e-104 304.0 ACY89858 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) Formate hydrogenlyase subunit 3 unaffected pathogenicity Gene deletion: full Z1_01733 RsmA PHI:10573 C6DEY6 554 77.4 265 60 0 1 265 1 265 9.32e-151 420.0 0 0 0 0 0 0 0 0 0 0 Z1_02941 KdpE PHI:6314 Q48K32 317 47.5 221 116 0 6 226 7 227 9.32e-75 224.0 0 0 0 0 0 0 0 0 0 0 Z1_00063 HilC PHI:631 P0CL09 28901 43.6 94 53 0 157 250 193 286 9.36e-15 70.9 0 0 0 0 0 0 0 0 0 0 Z1_01311 Crp PHI:4063 Q7CFV3 632 98.6 210 3 0 1 210 1 210 9.36e-150 412.0 AE014000_4 Yersinia pestis CO92 Pneumonic plague Rodents 10090 Mus musculus (related: house mouse) transcriptional regulator reduced virulence Gene mutation Z1_02782 FabI PHI:7915 Q2FZQ3 1280 44.8 250 135 2 4 251 4 252 9.409999999999999e-67 206.0 0 0 0 0 0 0 0 0 0 0 Z1_03514 ModA10 PHI:5422 P45323 727 51.4 259 114 4 1 254 1 252 9.42e-78 234.0 0 0 0 0 0 0 0 0 0 0 Z1_02796 TyrR PHI:4563 Q0WEH7 632 65.6 518 173 3 1 515 1 516 9.45e-239 664.0 CAL20972 Yersinia pestis 201 Plague Rodents 10090 Mus musculus (related: house mouse) regulator of aromatic amino acid metabolism reduced virulence Gene deletion: full; gene complementation Z1_03504 UvrB PHI:11576 Q8DYL6 1311 57.7 659 272 3 5 663 10 661 9.46e-263 736.0 0 0 0 0 0 0 0 0 0 0 Z1_03142 STM14_RS07800_(orf319) PHI:10119 A0A0F6B0Y3 28901 54.3 317 145 0 15 331 2 318 9.59e-130 371.0 0 0 0 0 0 0 0 0 0 0 Z1_02752 STM14_RS07740_(lpp) PHI:10106 A0A0F6B0X1 28901 75.6 78 17 1 2 79 3 78 9.61e-19 71.2 0 0 0 0 0 0 0 0 0 0 Z1_00603 YhbU PHI:11411 A0A0W8AWM7 573 86.4 331 45 0 1 331 1 331 9.660000000000001e-217 592.0 0 0 0 0 0 0 0 0 0 0 Z1_03008 MdtI PHI:8967 B5XR94 573 70.1 107 32 0 4 110 3 109 9.82e-49 149.0 0 0 0 0 0 0 0 0 0 0 Z1_02222 RpoE PHI:5238 B4F053 584 100.0 192 0 0 1 192 1 192 9.859999999999999e-134 370.0 CAR43933 Proteus mirabilis N2 Urinary tract infection Rodents 10090 Mus musculus (related: house mouse) RNA polymerase sigma-E factor reduced virulence Gene disruption; gene complementation Z1_00749 IlvA PHI:9318 D4HUI1 552 79.0 515 106 1 1 515 1 513 9.86e-298 813.0 0 0 0 0 0 0 0 0 0 0 Z1_02511 FliC PHI:2642 D0Z9I9 636 50.5 422 146 6 1 365 1 416 9.909999999999999e-89 271.0 ACY84965 Edwardsiella tarda H1 Edwardsiellosis Bony fishes 7955 Danio rerio (related: zebrafish) Flagellin Protein reduced virulence Gene deletion: full; gene complementation Z1_03341 AAT PHI:11103 A0A125YKR6 5811 43.2 396 221 4 1 392 192 587 9.92e-107 325.0 ESS34268 Toxoplasma gondii RH Toxoplasmosis Primates 9534 Chlorocebus aethiops (related: grivet) Aspartate aminotransferase reduced virulence Gene deletion: full; gene complementation Z1_00146 Ipx10 PHI:2975 Q9JP38 317 44.3 244 123 3 65 302 97 333 9.97e-61 204.0 0 0 0 0 0 0 0 0 0 0