Gene_ID Gene PHI_MolConn_ID Protein.ID Pathogen.ID Identity length mismatch gapopen qstart qend sstart send E_value bitscore Gene.ID Pathogen.species Pathogen.strain Disease Host.description Host.ID Host.species Gene.Function Mutant.Phenotype Exp..Technique.stable C1_01567 FumA PHI:10046 P40720 28901 95.8 543 23 0 1 543 1 543 0.0 1051.0 0 0 0 0 0 0 0 0 0 0 C1_03486 FumB PHI:10047 Q8ZKE2 28901 93.1 548 38 0 1 548 1 548 0.0 1038.0 0 0 0 0 0 0 0 0 0 0 C1_04214 GlgA PHI:10051 P05416 28901 94.3 477 27 0 1 477 1 477 0.0 919.0 0 0 0 0 0 0 0 0 0 0 C1_00422 STM14_RS15250 PHI:10063 A0A0F6B5Q4 28901 84.7 743 114 0 1 743 1 743 0.0 1218.0 ACY89848 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) Electron transport protein unaffected pathogenicity Gene deletion: full C1_00410 STM14_RS15285 PHI:10070 A0A0F6B5R3 28901 96.8 569 18 0 1 569 1 569 0.0 1132.0 ACY89857 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) Formate hydrogenlyase subunit 4 unaffected pathogenicity Gene deletion: full C1_00408 STM14_RS15295 PHI:10072 A0A0F6B5R5 28901 89.0 608 67 0 1 608 1 608 0.0 1040.0 ACY89859 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) Formate hydrogenlyase subunit 2 unaffected pathogenicity Gene deletion: full C1_02048 TreA PHI:10199 P13482 562 99.6 565 2 0 1 565 1 565 0.0 1157.0 0 0 0 0 0 0 0 0 0 0 C1_03172 LptD PHI:10312 P31554 562 100.0 784 0 0 1 784 1 784 0.0 1615.0 BAA34130 Escherichia coli KP7600 Urinary tract infection Moths 7091 Bombyx mori (related: domestic silkworm) LPS-assembly protein increased virulence (hypervirulence) Gene mutation C1_02017 NarG PHI:10512 P09152 562 99.8 1247 3 0 1 1247 1 1247 0.0 2595.0 0 0 0 0 0 0 0 0 0 0 C1_02016 NarH PHI:10513 P11349 562 99.8 512 1 0 1 512 1 512 0.0 1065.0 0 0 0 0 0 0 0 0 0 0 C1_01734 NarZ PHI:10516 P19319 562 99.8 1246 2 0 1 1246 1 1246 0.0 2609.0 0 0 0 0 0 0 0 0 0 0 C1_01735 NarY PHI:10517 P19318 562 99.6 514 2 0 1 514 1 514 0.0 1076.0 0 0 0 0 0 0 0 0 0 0 C1_00966 NapA PHI:10522 P33937 562 100.0 828 0 0 1 828 1 828 0.0 1701.0 0 0 0 0 0 0 0 0 0 0 C1_03978 SpoT PHI:10548 A0A0D6I2I2 28901 98.2 703 12 1 1 702 1 703 0.0 1343.0 0 0 0 0 0 0 0 0 0 0 C1_02356 Hcp PHI:10593 C6DF39 554 77.5 550 124 0 1 550 1 550 0.0 879.0 0 0 0 0 0 0 0 0 0 0 C1_03008 ImpL PHI:10594 A0A1M5U341 554 44.4 1170 626 13 17 1174 9 1165 0.0 931.0 0 0 0 0 0 0 0 0 0 0 C1_00554 ClpB PHI:10595 C6DC70 554 84.0 857 137 0 1 857 1 857 0.0 1367.0 0 0 0 0 0 0 0 0 0 0 C1_00424 NorV PHI:10668 A0A6C8TBQ7 562 99.8 479 1 0 1 479 1 479 0.0 986.0 0 0 0 0 0 0 0 0 0 0 C1_02094 PhoQ PHI:10954 P23837 562 100.0 486 0 0 1 486 1 486 0.0 934.0 0 0 0 0 0 0 0 0 0 0 C1_00111 SufI PHI:10978 A7ZRQ3 562 100.0 470 0 0 1 470 1 470 0.0 957.0 0 0 0 0 0 0 0 0 0 0 C1_02915 YahJ PHI:10984 P77554 562 98.7 460 6 0 1 460 1 460 0.0 904.0 0 0 0 0 0 0 0 0 0 0 C1_03108 CueO PHI:10985 P36649 562 99.2 516 4 0 1 516 1 516 0.0 1022.0 0 0 0 0 0 0 0 0 0 0 C1_01123 WcaM PHI:10990 P71244 562 97.8 464 10 0 1 464 1 464 0.0 907.0 0 0 0 0 0 0 0 0 0 0 C1_01779 MdoD PHI:10993 P40120 562 99.8 539 1 0 1 539 13 551 0.0 1126.0 0 0 0 0 0 0 0 0 0 0 C1_03724 FdoG PHI:10994 P32176 562 99.9 804 1 0 1 804 213 1016 0.0 1675.0 0 0 0 0 0 0 0 0 0 0 C1_01728 FdnG PHI:10997 P24183 562 99.6 803 3 0 1 803 213 1015 0.0 1662.0 0 0 0 0 0 0 0 0 0 0 C1_03750 BipA PHI:11030 A0A380PIP1 632 88.9 606 67 0 1 606 1 606 0.0 1075.0 0 0 0 0 0 0 0 0 0 0 C1_01318 Edd PHI:11150 Q6D652 29471 75.7 601 146 0 1 601 1 601 0.0 916.0 0 0 0 0 0 0 0 0 0 0 C1_01337 MAM_(YPK_1779) PHI:11187 A0A0H3B2K4 633 68.2 877 277 1 1 877 1 875 0.0 1216.0 0 0 0 0 0 0 0 0 0 0 C1_00894 NuoG PHI:11247 Q9I0J6 287 67.0 908 297 2 1 908 1 905 0.0 1254.0 0 0 0 0 0 0 0 0 0 0 C1_01444 KatE PHI:11380 H9L460 28901 87.3 750 93 1 4 753 3 750 0.0 1341.0 0 0 0 0 0 0 0 0 0 0 C1_03670 KatG PHI:11381 P17750 28901 92.0 725 58 0 1 725 1 725 0.0 1361.0 0 0 0 0 0 0 0 0 0 0 C1_02326 DmsA PHI:11664 P45004 727 73.3 803 211 3 13 814 6 806 0.0 1238.0 0 0 0 0 0 0 0 0 0 0 C1_03450 FrdA PHI:2960 C5BDL7 67780 85.0 602 87 1 1 602 1 599 0.0 1042.0 0 0 0 0 0 0 0 0 0 0 C1_00250 GcvP PHI:2961 C5BAT0 67780 74.7 959 240 2 1 956 1 959 0.0 1436.0 0 0 0 0 0 0 0 0 0 0 C1_00953 RcsC11 PHI:3011 P58662 28901 89.2 947 102 0 1 947 1 947 0.0 1665.0 0 0 0 0 0 0 0 0 0 0 C1_02138 RNase_E PHI:3723 E8XEV4 28901 78.0 1075 214 13 1 1061 1 1067 0.0 1376.0 0 0 0 0 0 0 0 0 0 0 C1_04471 Pnp PHI:3878 Q8ZLT3 28901 97.2 711 20 0 1 711 1 711 0.0 1311.0 0 0 0 0 0 0 0 0 0 0 C1_02350 MacB PHI:3928 Q8ZQE4 28901 83.2 648 109 0 1 648 1 648 0.0 1026.0 AAL19878 Salmonella enterica subsp. enterica serovar Typhimurium strain ATCC 14028 Food poisoning; enteritis Rodents 10090 Mus musculus (related: house mouse) ABC-Type Efflux Pump reduced virulence Gene deletion C1_00686 AcrD PHI:4043 D4HXR8 552 78.3 1018 221 0 19 1036 1 1018 0.0 1551.0 CBA21871 Erwinia amylovora Ea1189 Fire blight Eudicots 23211 Pyrus communis (related: pear) a resistance-nodulation-cell division (RND) transporter unaffected pathogenicity Gene disruption; gene complementation C1_03005 T6SS2 PHI:4559 Q6TKU1 562 88.5 942 82 4 1 939 1 919 0.0 1552.0 KF678350 Escherichia coli TW-XM Meningitis Birds 8839 Anas platyrhynchos (related: mallard) Type VI secretion systems (T6SSs) effectors effector (plant avirulence determinant) Gene mutation; gene complementation C1_02993 VgrG PHI:4560 D3QWN3 562 99.2 713 6 0 1 713 1 713 0.0 1166.0 ADD54889 Escherichia coli TW-XM Meningitis Birds 8839 Anas platyrhynchos (related: mallard) Type VI secretion systems (T6SSs) effectors effector (plant avirulence determinant) Gene mutation; gene complementation C1_01558 PafP PHI:4631 P19642 562 99.6 530 2 0 1 530 1 530 0.0 1029.0 0 0 0 0 0 0 0 0 0 0 C1_04105 BcsA PHI:4694 D0ZKI3 28901 88.3 871 102 0 1 871 1 871 0.0 1590.0 0 0 0 0 0 0 0 0 0 0 C1_00647 Ppk PHI:5063 B4EY92 584 79.0 691 139 3 1 687 1 689 0.0 1107.0 0 0 0 0 0 0 0 0 0 0 C1_03131 SecA PHI:5240 A0A059ZR97 470 58.9 913 356 8 1 900 1 907 0.0 1019.0 0 0 0 0 0 0 0 0 0 0 C1_01942 RpfR PHI:5504 C9XTL5 413502 73.6 659 174 0 1 659 21 679 0.0 957.0 0 0 0 0 0 0 0 0 0 0 C1_00562 Pat PHI:5571__PHI:6366 Q8ZMX2 28901 92.2 886 69 0 1 886 1 886 0.0 1615.0 0 0 0 0 0 0 0 0 0 0 C1_00354 BarA PHI:562 Q8Z445 28901 90.0 921 86 2 1 918 1 918 0.0 1624.0 0 0 0 0 0 0 0 0 0 0 C1_02022 YchO PHI:6184 P39165 562 99.4 464 3 0 1 464 1 464 0.0 943.0 0 0 0 0 0 0 0 0 0 0 C1_02892 LacZ PHI:6268__PHI:9897 P00722 562 98.7 1024 13 0 1 1024 1 1024 0.0 2132.0 0 0 0 0 0 0 0 0 0 0 C1_02766 HtpG PHI:6472 P0A6Z3 562 99.8 624 1 0 1 624 1 624 0.0 1216.0 0 0 0 0 0 0 0 0 0 0 C1_01280 CheA PHI:6535 P07363 562 99.4 654 4 0 1 654 1 654 0.0 1219.0 0 0 0 0 0 0 0 0 0 0 C1_01494 SufB__STM14_RS07705_(sufB) PHI:6893__PHI:10099 A0A0F6B0W4 28901 96.0 495 20 0 1 495 1 495 0.0 969.0 0 0 0 0 0 0 0 0 0 0 C1_04236 FeoB PHI:6941 A0A0F6UGK4 287 67.2 744 240 2 1 743 1 741 0.0 958.0 0 0 0 0 0 0 0 0 0 0 C1_00159 YghJ PHI:7003 E3PJ90 562 89.9 1526 146 5 1 1525 1 1519 0.0 2684.0 CBJ02741 Escherichia coli Urinary tract infection Rodents 10090 Mus musculus (related: house mouse) Secreted metalloprotease and surface associated lipoprotein unaffected pathogenicity Functional test in host: direct injection C1_03393 CpdB PHI:7020 P08331 562 99.8 647 1 0 1 647 1 647 0.0 1292.0 0 0 0 0 0 0 0 0 0 0 C1_02777 AcrB PHI:7307 A0A0H3N916 28901 94.7 1048 56 0 1 1048 1 1048 0.0 1890.0 CBW16569 Salmonella enterica subsp. enterica serovar Typhimurium strain SL1344 Salmonellosis Rodents 10090 Mus musculus (related: house mouse) Efflux pump membrane transporter reduced virulence Gene mutation C1_02610 EntE_(VK055_1924) PHI:7486 W9B580 573 81.3 529 99 0 3 531 2 530 0.0 879.0 0 0 0 0 0 0 0 0 0 0 C1_02621 FepA_(VK055_1934) PHI:7538 W9B570 573 81.4 751 126 5 1 746 1 742 0.0 1233.0 0 0 0 0 0 0 0 0 0 0 C1_02618 EntF_(VK055_1931) PHI:7540 B5XZY6 573 77.8 1293 284 2 1 1291 1 1292 0.0 1996.0 0 0 0 0 0 0 0 0 0 0 C1_03276 YjiY PHI:7575 Q8ZJY5 28901 96.6 716 24 0 1 716 1 716 0.0 1378.0 0 0 0 0 0 0 0 0 0 0 C1_02606 CstA PHI:7577 Q8ZR28 28901 97.4 701 18 0 1 701 1 701 0.0 1305.0 0 0 0 0 0 0 0 0 0 0 C1_03751 GlnA PHI:7742 P0A1P6 28901 98.1 469 9 0 1 469 1 469 0.0 929.0 0 0 0 0 0 0 0 0 0 0 C1_03624 RpoB PHI:7860 A3M1G3 470 70.9 1363 366 10 1 1338 1 1357 0.0 1868.0 ABO10757 Acinetobacter baumannii ATCC 17978 Nosocomial infection Nematodes 6239 Caenorhabditis elegans (related: roundworm) beta-subunit of the RNA polymerase reduced virulence Gene mutation; gene complementation C1_00918 ArnA PHI:7951 A6TF98 573 77.3 657 149 0 1 657 1 657 0.0 1056.0 0 0 0 0 0 0 0 0 0 0 C1_02484 SdhA PHI:7964 P0AC41 562 99.8 588 1 0 1 588 1 588 0.0 1182.0 0 0 0 0 0 0 0 0 0 0 C1_03917 TnaA PHI:7966 P0A853 562 100.0 471 0 0 1 471 1 471 0.0 946.0 0 0 0 0 0 0 0 0 0 0 C1_00946 GyrA PHI:849 Q75WC1 337 58.6 862 347 3 1 852 1 862 0.0 968.0 BAC98438 Burkholderia glumae M3 Bacterial grain rot Monocots 4530 Oryza sativa (related: rice) DNA gyrase (bacterial topoisomerase II) chemistry target: sensitivity to chemical Gene mutation: characterised C1_03704 CpxA PHI:8513__PHI:8689 D2TU77 67825 98.5 457 7 0 1 457 1 457 0.0 877.0 0 0 0 0 0 0 0 0 0 0 C1_02347 ClpA_(Dda3937_02363) PHI:8569 E0SMW9 204038 90.2 757 73 1 1 757 1 756 0.0 1323.0 0 0 0 0 0 0 0 0 0 0 C1_00367 CysJ_(Dda3937_00209) PHI:8574 E0SDK2 204038 75.5 608 139 3 1 599 1 607 0.0 893.0 0 0 0 0 0 0 0 0 0 0 C1_01289 FlhA PHI:8731 P40729 28901 95.4 692 32 0 1 692 1 692 0.0 1242.0 0 0 0 0 0 0 0 0 0 0 C1_02799 Lon PHI:8808 A0A0F6AXS9 28901 99.4 784 5 0 1 784 1 784 0.0 1495.0 0 0 0 0 0 0 0 0 0 0 C1_03153 LeuA PHI:8962 B5Y1W2 573 92.7 523 38 0 1 523 1 523 0.0 957.0 0 0 0 0 0 0 0 0 0 0 C1_03155 LeuC PHI:8964 W9BBU8 573 97.4 466 12 0 1 466 1 466 0.0 903.0 0 0 0 0 0 0 0 0 0 0 C1_01475 YdiD PHI:9092 Q8ZPS2 28901 83.0 542 92 0 1 542 1 542 0.0 936.0 0 0 0 0 0 0 0 0 0 0 C1_00175 SpeC PHI:9151 P21169 562 98.9 711 8 0 1 711 1 711 0.0 1435.0 0 0 0 0 0 0 0 0 0 0 C1_00356 RelA PHI:9161 Q8Z447 28901 96.1 743 29 0 1 743 1 743 0.0 1439.0 AAO70421 Salmonella enterica subsp. enterica serovar Typhimurium strain SL1344 Salmonellosis Primates 9606 Homo sapiens (related: human) GTP pyrophosphokinase reduced virulence Gene deletion: full; gene complementation C1_03972 HilE_(STM14_4514) PHI:9177 A0A0F6B8Q0 28901 80.4 567 111 0 1 567 1 567 0.0 916.0 0 0 0 0 0 0 0 0 0 0 C1_01091 YegN PHI:9198 W8ZK20 562 99.7 1040 3 0 1 1040 1 1040 0.0 1900.0 0 0 0 0 0 0 0 0 0 0 C1_03535 Acs PHI:9227 P27550 562 100.0 652 0 0 1 652 1 652 0.0 1347.0 0 0 0 0 0 0 0 0 0 0 C1_03537 ActP PHI:9229 P32705 562 99.8 549 1 0 1 549 1 549 0.0 1028.0 0 0 0 0 0 0 0 0 0 0 C1_04061 MalS PHI:9246 Q8Z2C1 28901 81.7 676 123 1 1 676 1 675 0.0 1179.0 0 0 0 0 0 0 0 0 0 0 C1_03891 GlmS PHI:9308 D4I4L2 552 84.1 609 97 0 1 609 1 609 0.0 1005.0 0 0 0 0 0 0 0 0 0 0 C1_03582 Pgi PHI:9310 D4I2T0 552 83.6 548 89 1 1 548 1 547 0.0 949.0 0 0 0 0 0 0 0 0 0 0 C1_03790 MetE PHI:9315 D4HUM7 552 85.4 752 109 1 1 751 1 752 0.0 1323.0 0 0 0 0 0 0 0 0 0 0 C1_00864 PurF PHI:9317 D4HXG4 552 88.9 505 56 0 1 505 1 505 0.0 899.0 0 0 0 0 0 0 0 0 0 0 C1_03851 IlvA PHI:9318 D4HUI1 552 85.8 514 73 0 2 515 1 514 0.0 881.0 0 0 0 0 0 0 0 0 0 0 C1_00590 PurL PHI:9320 D4HYF4 552 84.3 1295 202 1 1 1295 1 1294 0.0 2205.0 0 0 0 0 0 0 0 0 0 0 C1_03656 Ppc PHI:9322 D4HUG1 552 83.6 883 145 0 1 883 1 883 0.0 1494.0 0 0 0 0 0 0 0 0 0 0 C1_00368 CysI3 PHI:9323 D4HWM2 552 83.1 567 96 0 3 569 4 570 0.0 992.0 0 0 0 0 0 0 0 0 0 0 C1_02533 AsnB PHI:9327 D4HYW4 552 87.4 554 69 1 1 553 1 554 0.0 997.0 0 0 0 0 0 0 0 0 0 0 C1_00730 PtsI PHI:9499 C3T127 562 100.0 575 0 0 1 575 1 575 0.0 1088.0 0 0 0 0 0 0 0 0 0 0 C1_03817 Cya PHI:9840 Q9KVL9 666 55.3 835 361 8 1 827 1 831 0.0 915.0 0 0 0 0 0 0 0 0 0 0 C1_00879 Pta PHI:9842 Q9KT08 666 74.6 714 180 1 1 714 1 713 0.0 1042.0 0 0 0 0 0 0 0 0 0 0 C1_01341 Prc PHI:9896 P23865 562 99.7 682 2 0 1 682 1 682 0.0 1314.0 BAA00577 Escherichia coli RS218 Urinary tract infection Rodents 10090 Mus musculus (related: house mouse) Tail-specific protease reduced virulence Gene mutation; gene complementation C1_00371 Cas3_(AV79_16420) PHI:9967 A0A638ILJ8 28901 70.5 668 196 1 15 681 1 668 0.0 968.0 0 0 0 0 0 0 0 0 0 0 C1_01691 LsrK PHI:9990 P77432 562 99.8 530 1 0 1 530 1 530 0.0 1063.0 0 0 0 0 0 0 0 0 0 0 C1_01689 LsrA PHI:9992 P77257 562 98.8 511 6 0 1 511 1 511 0.0 970.0 0 0 0 0 0 0 0 0 0 0 C1_04472 NlpI PHI:2459 D4ICB6 552 88.4 294 34 0 1 294 1 294 1.01e-188 518.0 0 0 0 0 0 0 0 0 0 0 C1_01539 MliC PHI:2646 E0IWR8 562 100.0 107 0 0 1 107 1 107 1.01e-76 219.0 ADT75274 Escherichia coli CH2 Colibacillosis; cellulitis; swollen head syndrome Birds 9031 Gallus gallus (related: chicken) Lysozyme inhibitor reduced virulence Gene deletion: full; gene complementation C1_03317 mI PHI:10208 B0LF83 573 75.5 163 40 0 3 165 16 178 1.01e-93 268.0 0 0 0 0 0 0 0 0 0 0 C1_01923 PspA PHI:7657 A0A0F6B1X1 28901 91.4 222 19 0 1 222 1 222 1.02e-127 358.0 0 0 0 0 0 0 0 0 0 0 C1_01253 Ctp_(NMB0788) PHI:8622 Q9K034 487 56.4 163 71 0 54 216 54 216 1.02e-57 180.0 0 0 0 0 0 0 0 0 0 0 C1_00297 KduD PHI:10587 A0A518VKX7 554 83.8 253 41 0 1 253 1 253 1.0300000000000001e-156 434.0 0 0 0 0 0 0 0 0 0 0 C1_02470 RSp0672 PHI:10834 Q3J038 305 43.6 218 121 1 3 220 13 228 1.03e-51 166.0 CAD17823 Ralstonia solanacearum OE1-1 Bacterial wilt Eudicots 4111 Solanum melongena (related: eggplant) Effector protein effector (plant avirulence determinant) Gene deletion: full C1_02093 PhoP PHI:10955 P23836 562 99.6 223 1 0 1 223 1 223 1.04e-157 434.0 0 0 0 0 0 0 0 0 0 0 C1_01575 SssB PHI:3780 D0ZX10 28901 89.5 314 33 0 1 314 1 314 1.0600000000000001e-200 550.0 0 0 0 0 0 0 0 0 0 0 C1_01518 LhnR PHI:3491 Q0GPY7 373 50.9 57 28 0 6 62 19 75 1.06e-06 47.8 0 0 0 0 0 0 0 0 0 0 C1_02576 LipA PHI:6492 V5VBJ6 470 58.1 320 131 2 1 320 1 317 1.06e-130 374.0 0 0 0 0 0 0 0 0 0 0 C1_03842 Rho PHI:8558 T1YC56 1280 52.0 415 190 5 7 419 24 431 1.06e-149 430.0 AGU62228 Staphylococcus aureus HG001 Nosocomial infection Rodents 10090 Mus musculus (related: house mouse) Transcriptional regulator increased virulence (hypervirulence) Gene mutation; gene complementation C1_03781 TatC PHI:10983 P69423 562 100.0 258 0 0 1 258 1 258 1.06e-172 474.0 0 0 0 0 0 0 0 0 0 0 C1_04164 MGA_0220 PHI:7715 Q7NAX1 2096 41.0 122 72 0 122 243 208 329 1.06e-24 100.0 AAP56864 Mycoplasma gallisepticum Ap3AS Airsacculitis Birds 9031 Gallus gallus (related: chicken) Oligopeptide transporter ATP-binding protein OppD1 reduced virulence Gene deletion: full; gene complementation C1_03210 NhaA PHI:3266 P13738 562 99.2 388 3 0 1 388 1 388 1.06e-267 726.0 0 0 0 0 0 0 0 0 0 0 C1_03691 GLPX__GPM2 PHI:6486__PHI:6487 P9WN21 1773 42.8 325 172 2 3 326 31 342 1.0700000000000001e-86 263.0 0 0 0 0 0 0 0 0 0 0 C1_04287 ArgD PHI:8863 B5F8I0 28901 91.3 404 35 0 1 404 1 404 1.0799999999999999e-278 755.0 ACH49836 Salmonella enterica subsp. enterica serovar Agona strain Ag 1 Infection Rodents 10090 Mus musculus (related: house mouse) Acetylornithine/succinyldiaminopimelate aminotransferase reduced virulence Gene mutation C1_01821 Ompk35__OmpK35 PHI:9529__PHI:10186 O87753 573 56.3 378 144 7 1 377 2 359 1.07e-140 402.0 0 0 0 0 0 0 0 0 0 0 C1_01309 ZnuB PHI:11006 P39832 562 94.6 261 14 0 1 261 1 261 1.08e-162 449.0 0 0 0 0 0 0 0 0 0 0 C1_04372 ModK1 PHI:10188 A0A2H4QBA5 504 41.0 83 38 1 198 280 517 588 1.09e-07 51.2 0 0 0 0 0 0 0 0 0 0 C1_01579 MdtJ PHI:8966 A0A1C1TY69 573 82.2 118 21 0 4 121 3 120 1.09e-57 172.0 0 0 0 0 0 0 0 0 0 0 C1_01684 LsrG PHI:9997 P64461 562 99.0 96 1 0 1 96 1 96 1.11e-68 198.0 0 0 0 0 0 0 0 0 0 0 C1_04123 ZmpR PHI:3008 Q9S1J0 1313 40.3 67 37 1 167 233 176 239 1.12e-06 46.6 0 0 0 0 0 0 0 0 0 0 C1_03625 Rv0652_(rplL) PHI:7583 P9WHE3 1773 43.3 127 64 2 3 121 4 130 1.12e-17 71.6 0 0 0 0 0 0 0 0 0 0 C1_02965 ProA PHI:11263 A5ICA4 446 40.1 411 239 4 8 416 11 416 1.12e-93 286.0 0 0 0 0 0 0 0 0 0 0 C1_03899 PstB PHI:3412 Q8PM59 346 66.5 251 84 0 7 257 17 267 1.1300000000000001e-125 356.0 0 0 0 0 0 0 0 0 0 0 C1_01506 YdhX PHI:10998 P77375 562 99.5 222 1 0 1 222 1 222 1.1399999999999999e-174 476.0 0 0 0 0 0 0 0 0 0 0 C1_02948 YagT PHI:10988 J7QMF7 562 99.6 229 1 0 1 229 1 229 1.13e-164 452.0 0 0 0 0 0 0 0 0 0 0 C1_03275 Tsr PHI:6981 A0A0F6BB74 28901 80.5 554 107 1 1 554 1 553 1.14e-245 684.0 0 0 0 0 0 0 0 0 0 0 C1_00732 MecA PHI:6556 Q4X256 746128 42.0 312 167 6 12 314 21 327 1.14e-64 211.0 0 0 0 0 0 0 0 0 0 0 C1_01939 FabI PHI:7915 Q2FZQ3 1280 43.6 250 138 2 4 251 4 252 1.1699999999999998e-67 208.0 0 0 0 0 0 0 0 0 0 0 C1_03652 ArgH PHI:2632 Q2FIB5 1280 47.9 453 235 1 4 456 6 457 1.16e-147 427.0 0 0 0 0 0 0 0 0 0 0 C1_03702 CpxP PHI:8515 D2TU75 67825 88.6 166 19 0 1 166 1 166 1.16e-92 265.0 0 0 0 0 0 0 0 0 0 0 C1_03840 WecA PHI:4074 V6A547 615 76.2 357 85 0 2 358 17 373 1.17e-199 552.0 0 0 0 0 0 0 0 0 0 0 C1_00128 HybO PHI:10996 P69741 562 100.0 372 0 0 1 372 1 372 1.17e-281 759.0 0 0 0 0 0 0 0 0 0 0 C1_04133 DctR PHI:11605 P37195 562 100.0 176 0 0 1 176 1 176 1.1800000000000001e-124 346.0 0 0 0 0 0 0 0 0 0 0 C1_03331 Rdf PHI:9805 A0A6C7HRI3 28901 43.4 53 30 0 25 77 12 64 1.18e-10 50.8 0 0 0 0 0 0 0 0 0 0 C1_02528 MoDeam PHI:5472 G4NB53 318829 60.2 259 103 0 1 259 1 259 1.1e-116 337.0 EHA48815 Magnaporthe oryzae KJ201 Blast (rice) Monocots 4530 Oryza sativa (related: rice) GlcN-6-phosphate deaminase reduced virulence Gene deletion: full; gene complementation C1_03519 YraS PHI:3268 U3M7S2 29486 40.1 633 368 5 32 661 43 667 1.1e-161 479.0 AGT97036 Yersinia ruckeri 150 Enteric redmouth disease Bony fishes 8022 Oncorhynchus mykiss (related: rainbow trout) Heat sensitive alkyl sulphatase unaffected pathogenicity Gene mutation: characterised; gene complementation C1_02312 AroA PHI:9459 P19786 28901 89.7 427 44 0 1 427 1 427 1.21e-279 759.0 0 0 0 0 0 0 0 0 0 0 C1_01884 ECA3851 PHI:7691 Q6D0E8 29471 42.8 166 88 2 248 410 368 529 1.2299999999999999e-30 121.0 CAG76749 Pectobacterium atrosepticum SCRI 1043 Soft rot (potato); blackleg disease (potato) Eudicots 4113 Solanum tuberosum (related: potato) Cyclic-di-GMP signalling protein reduced virulence Altered gene expression / gene regulation: overexpression C1_04227 NarL PHI:3620 P9WGM5 1773 50.9 57 28 0 836 892 155 211 1.22e-08 54.7 0 0 0 0 0 0 0 0 0 0 C1_04352 AroE_(XOC_4333) PHI:7791 G7TM49 347 45.0 269 142 5 4 267 6 273 1.22e-62 197.0 0 0 0 0 0 0 0 0 0 0 C1_04111 Ypo3991 PHI:4189 Q7CG15 632 62.1 478 180 1 1 477 1 478 1.2399999999999999e-219 613.0 0 0 0 0 0 0 0 0 0 0 C1_04345 RsmB PHI:2694 Q6D000 29471 71.5 428 122 0 1 428 1 428 1.23e-229 633.0 0 0 0 0 0 0 0 0 0 0 C1_00284 PrdR PHI:9139 Q17ZY8 1496 42.6 324 169 5 270 589 271 581 1.23e-72 242.0 CAJ70142 Clostridioides difficile JIR8094 Pseudomembranous colitis Rodents 10036 Mesocricetus auratus (related: golden hamster) Proline-responsive regulatory protein increased virulence (hypervirulence) Gene deletion: full; gene complementation C1_02609 EntB__EntB_(VK055_1923) PHI:6565__PHI:6652__PHI:7479 W9BNM8 573 87.3 284 34 1 1 284 1 282 1.2400000000000001e-184 507.0 0 0 0 0 0 0 0 0 0 0 C1_02924 IcsA PHI:4647__PHI:9890 Q7BCK4 623 44.4 520 276 4 814 1327 590 1102 1.24e-117 393.0 0 0 0 0 0 0 0 0 0 0 C1_02522 Fur PHI:4887 P0A9A9 562 100.0 148 0 0 1 148 1 148 1.2500000000000001e-110 308.0 CAA26429 Escherichia coli CFT073 Urinary tract infection Rodents 10090 Mus musculus (related: house mouse) global ferric uptake regulator reduced virulence Gene deletion: full; gene complementation C1_02581 PagP PHI:9385 A0A0H2YXJ2 562 97.8 186 4 0 1 186 1 186 1.2599999999999999e-142 392.0 0 0 0 0 0 0 0 0 0 0 C1_03133 LpxC PHI:10612 B2I1I9 470 51.2 297 144 1 1 297 1 296 1.25e-111 323.0 0 0 0 0 0 0 0 0 0 0 C1_01501 STM14_RS07745_(pykF) PHI:10107 A0A0F6B0X2 28901 95.7 470 20 0 1 470 1 470 1.25e-319 864.0 0 0 0 0 0 0 0 0 0 0 C1_02265 LonC PHI:5467 A3N3I4 715 42.1 430 240 5 115 541 73 496 1.26e-93 296.0 ABN74970 Actinobacillus pleuropneumoniae LD20 Lung infection Rodents 10090 Mus musculus (related: house mouse) Lon proteases unaffected pathogenicity Gene mutation C1_00295 ERG10 PHI:2529 Q4WCL5 746128 42.4 394 222 4 1 390 4 396 1.2799999999999999e-95 290.0 XP_747207 Aspergillus fumigatus CEA10 Invasive pulmonary aspergillosis Lethal pathogen phenotype Lethal pathogen phenotype Lethal pathogen phenotype Acetyl-CoA acetyl-transferase lethal Altered gene expression / gene regulation C1_02611 EntC_(VK055_1925) PHI:7487 A0A085DFX7 573 75.4 391 96 0 1 391 1 391 1.2800000000000002e-212 587.0 0 0 0 0 0 0 0 0 0 0 C1_02776 AdeI PHI:6386 Q2FD95 470 47.0 400 198 7 7 395 7 403 1.28e-109 326.0 0 0 0 0 0 0 0 0 0 0 C1_00967 NapG PHI:10523__PHI:10986 P0AAL3 562 100.0 231 0 0 1 231 1 231 1.28e-171 469.0 0 0 0 0 0 0 0 0 0 0 C1_02815 XC_3703 PHI:3259 Q4UQD0 339 51.8 166 72 3 1 163 1 161 1.2900000000000001e-47 150.0 AAY50743 Xanthomonas campestris pv. campestris strain 8004 Black rot Eudicots 3726 Raphanus sativus (related: radish) Cyclic di-GMP Effectors reduced virulence Gene deletion: full C1_01281 CheW PHI:6536 P0A964 562 100.0 167 0 0 1 167 1 167 1.2900000000000002e-110 310.0 0 0 0 0 0 0 0 0 0 0 C1_00105 QseB PHI:6882 P66796 28901 87.6 218 27 0 1 218 1 218 1.29e-140 390.0 CAD03009 Salmonella enterica subsp. enterica serovar Typhi strain GIFU10007 Salmonellosis Primates 9606 Homo sapiens (related: human) Two-component system response regulator increased virulence (hypervirulence) Gene mutation; gene complementation C1_01808 PaaA PHI:3524__PHI:9576 B4E5A2 95486 66.1 301 102 0 6 306 26 326 1.29e-153 431.0 0 0 0 0 0 0 0 0 0 0 C1_01970 SEN1538 PHI:10387 A0A6C7HPB2 28901 93.3 30 2 0 1 30 1 30 1.2e-13 57.0 CAR33117 Salmonella enterica subsp. enterica serovar Enteritidis strain P125109 Salmonellosis Rodents 10090 Mus musculus (related: house mouse) Conserved hypothetical protein reduced virulence Gene deletion: full; gene complementation C1_00970 NapC PHI:10526 P0ABL5 562 100.0 200 0 0 1 200 1 200 1.2e-156 429.0 0 0 0 0 0 0 0 0 0 0 C1_02880 MoSFA1 PHI:4616 G4N4N6 318829 61.7 366 138 1 4 367 11 376 1.3100000000000001e-166 469.0 EHA52051 Magnaporthe oryzae Guy11 Blast (rice) Monocots 4530 Oryza sativa (related: rice) S-(Hydroxymethyl)Glutathione Dehydrogenase reduced virulence Gene deletion: full; gene complementation C1_02613 EntS_(VK055_1927) PHI:7481 W1B397 573 100.0 416 0 0 1 416 1 416 1.3199999999999999e-282 766.0 0 0 0 0 0 0 0 0 0 0 C1_00129 HybA PHI:10995 P0AAJ8 562 99.7 328 1 0 1 328 1 328 1.31e-258 697.0 0 0 0 0 0 0 0 0 0 0 C1_02483 SdhB PHI:7965 P07014 562 99.6 238 1 0 1 238 1 238 1.33e-181 495.0 0 0 0 0 0 0 0 0 0 0 C1_00447 LuxS PHI:3731 A1AEN2 562 99.4 171 1 0 1 171 1 171 1.34e-123 343.0 ABJ02122 Escherichia coli serotype O78:K80:H9 strain χ7122 Colibacillosis; cellulitis; swollen head syndrome Birds 9031 Gallus gallus (related: chicken) controller in the Quorum sensing reduced virulence Gene deletion; gene complementation C1_04014 EnvC PHI:5573 A0A0D6I3U0 28901 89.7 417 43 0 3 419 11 427 1.3500000000000001e-223 617.0 0 0 0 0 0 0 0 0 0 0 C1_02928 Bab2_0277 PHI:9126 Q2YIV2 235 40.3 531 307 8 3 531 5 527 1.3599999999999999e-112 343.0 0 0 0 0 0 0 0 0 0 0 C1_01274 OtsA PHI:9814 Q8XQW3 305 55.8 462 192 6 1 452 1 460 1.35e-177 504.0 0 0 0 0 0 0 0 0 0 0 C1_02619 SCAB_85461 PHI:11107 C9Z1K8 1930 42.2 64 37 0 4 67 2 65 1.36e-17 67.8 CBG75491 Streptomyces scabiei 87.22 Common scab (potato) Eudicots 4113 Solanum tuberosum (related: potato) Putative MbtH homolog reduced virulence Gene deletion: full; gene complementation C1_02351 MacA PHI:3929 E8XCP9 28901 83.9 367 59 0 3 369 4 370 1.37e-211 582.0 ADX1663 Salmonella enterica subsp. enterica serovar Typhimurium strain ATCC 14028 Food poisoning; enteritis Rodents 10090 Mus musculus (related: house mouse) ABC-Type Efflux Pump reduced virulence Gene deletion C1_01922 PspB PHI:7658 A0A0F6B1X0 28901 89.2 74 8 0 1 74 1 74 1.37e-41 128.0 0 0 0 0 0 0 0 0 0 0 C1_00379 XAC1722 PHI:4145 Q8PLR7 346 53.9 154 71 0 1 154 5 158 1.37e-54 168.0 AAM36589 Xanthomonas citri subsp. citri Canker (citrus) Eudicots 2711 Citrus sinensis (related: sweet orange) 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase reduced virulence Gene mutation C1_00648 PurN PHI:8652 P08179 562 99.1 212 2 0 1 212 1 212 1.38e-152 420.0 0 0 0 0 0 0 0 0 0 0 C1_02994 Hcp2 PHI:8554 A0A0G3K3H0 562 100.0 172 0 0 1 172 1 172 1.39e-130 361.0 0 0 0 0 0 0 0 0 0 0 C1_01805 PaaD PHI:3171 B4E599 95486 46.7 167 75 4 10 163 17 182 1.39e-47 151.0 0 0 0 0 0 0 0 0 0 0 C1_02806 XAC1258 PHI:4147 Q8PN16 346 59.0 266 104 3 20 282 20 283 1.3e-111 324.0 AAM36129 Xanthomonas citri subsp. citri Canker (citrus) Eudicots 2711 Citrus sinensis (related: sweet orange) CyoA, cytochrome O ubiquinol oxidase reduced virulence Gene mutation C1_01014 YeiE PHI:11609 Q8ZNK8 28901 91.3 287 25 0 1 287 1 287 1.3e-189 520.0 0 0 0 0 0 0 0 0 0 0 C1_00215 Tkt PHI:8028 Q8MPM3 5665 47.9 668 326 11 1 662 1 652 1.3e-196 568.0 CAD20572 Leishmania mexicana M379 Leishmaniasis Primates 9606 Homo sapiens (related: human) Transketolase loss of pathogenicity Gene deletion: full; gene complementation C1_00719 MurQ PHI:7350 Q2FK71 1280 46.4 293 157 0 3 295 2 294 1.3e-86 259.0 0 0 0 0 0 0 0 0 0 0 C1_03056 PXO_01122 PHI:3895 B2SR06 347 41.1 443 240 10 12 446 12 441 1.3e-97 298.0 ACD59567 Xanthomonas oryzae pv. oryzae strain PXO99A Bacterial leaf blight Monocots 4530 Oryza sativa (related: rice) PDZ domain-containing proteases reduced virulence Gene disruption; gene complementation C1_00456 ProV PHI:8968 A0A086IQC3 573 91.5 400 34 0 1 400 1 400 1.4199999999999998e-262 714.0 0 0 0 0 0 0 0 0 0 0 C1_03835 RmlA PHI:7634 Q9HU22 287 66.0 285 97 0 2 286 4 288 1.41e-139 394.0 0 0 0 0 0 0 0 0 0 0 C1_03079 FhuD PHI:10989 P07822 562 100.0 296 0 0 1 296 1 296 1.41e-221 601.0 0 0 0 0 0 0 0 0 0 0 C1_03152 LeuO PHI:7770 A0A0H6RQV7 666 53.6 295 134 2 19 312 20 312 1.42e-102 301.0 0 0 0 0 0 0 0 0 0 0 C1_03220 YaaA PHI:11408 A0A378CFB4 573 82.9 257 44 0 1 257 294 550 1.42e-148 424.0 0 0 0 0 0 0 0 0 0 0 C1_03995 WaaA PHI:7635 Q9HUH7 287 53.7 410 189 1 5 413 5 414 1.4300000000000002e-144 417.0 0 0 0 0 0 0 0 0 0 0 C1_00972 CcmA_(VK055_1938) PHI:7534 W1ATL3 573 64.5 211 75 0 10 220 216 426 1.4300000000000002e-79 243.0 0 0 0 0 0 0 0 0 0 0 C1_01365 YeaZ PHI:6870 A0A165G9C3 669 56.7 231 98 2 2 231 4 233 1.43e-85 252.0 0 0 0 0 0 0 0 0 0 0 C1_00846 XC_1565 PHI:3966 Q4UWE2 339 49.8 295 142 3 9 300 5 296 1.43e-88 265.0 AAY48631 Xanthomonas campestris pv. campestris strain 8004 Black rot Eudicots 3726 Raphanus sativus (related: radish) N-5-glutamine S-adenosyl-L-methionine-dependent methyltransferase reduced virulence Gene mutation C1_00406 STM14_RS15305 PHI:10074 A0A0F6B5R8 28901 88.8 152 17 0 1 152 1 152 1.43e-98 278.0 ACY89862 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) Hydrogenase maturation nickel metallochaperone unaffected pathogenicity Gene deletion: full C1_03195 CarA_(Dda3937_01390) PHI:8577 E0SH08 204038 87.4 380 48 0 1 380 1 380 1.4400000000000002e-248 677.0 0 0 0 0 0 0 0 0 0 0 C1_03019 Ipx10 PHI:2975 Q9JP38 317 41.0 266 152 3 12 274 79 342 1.44e-65 215.0 0 0 0 0 0 0 0 0 0 0 C1_01495 SufC PHI:6894 A0A0M2J080 28901 92.3 248 19 0 1 248 1 248 1.45e-165 456.0 0 0 0 0 0 0 0 0 0 0 C1_00414 STM14_RS15265 PHI:10066 A0A0F6B5Q9 28901 92.3 155 12 0 1 155 1 155 1.4799999999999999e-106 299.0 ACY89853 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) Formate hydrogenlyase maturation protein unaffected pathogenicity Gene deletion: full C1_03901 PafR PHI:4630 P11989 562 100.0 278 0 0 1 278 1 278 1.47e-189 519.0 AAA23509 Escherichia coli CFT073 Urinary tract infection Rodents 10090 Mus musculus (related: house mouse) Transcription Regulator reduced virulence Gene deletion: full; gene complementation C1_00954 RcsB PHI:3012 C4PCU2 28901 99.1 216 2 0 1 216 1 216 1.48e-149 412.0 0 0 0 0 0 0 0 0 0 0 C1_01765 YdcR PHI:7225 A0A0F6B1M0 28901 87.2 468 60 0 1 468 1 468 1.4900000000000002e-293 798.0 0 0 0 0 0 0 0 0 0 0 C1_01497 STM14_RS07720_(sufS) PHI:10102 A0A0F6B0W7 28901 87.4 406 51 0 1 406 1 406 1.49e-267 727.0 0 0 0 0 0 0 0 0 0 0 C1_03776 THIOL PHI:598 Q0QWD8 5022 40.7 354 192 8 45 386 10 357 1.49e-62 203.0 ABB55459 Leptosphaeria maculans ICBN 18 Phoma stem canker Eudicots 3708 Brassica napus (related: rape) 3-ketoacyl-CoA thiolase reduced virulence Altered gene expression / gene regulation: overexpression C1_00887 LrhA PHI:7647 P36771 562 99.7 312 1 0 1 312 1 312 1.4e-220 600.0 CAA52637 Escherichia coli PA45B Urinary tract infection Primates 9606 Homo sapiens (related: human) Probable HTH-type transcriptional regulator reduced virulence Altered gene expression / gene regulation: overexpression C1_02622 EntD_(VK055_1935) PHI:7537 B5XZZ0 573 54.1 205 92 1 4 206 1 205 1.51e-71 214.0 0 0 0 0 0 0 0 0 0 0 C1_00226 LmiA_(z4267) PHI:10953 A0A4V1DMY4 562 99.3 143 1 0 1 143 1 143 1.5299999999999998e-104 293.0 0 0 0 0 0 0 0 0 0 0 C1_00580 RNase_III PHI:3724 Q56056 28901 97.3 226 6 0 1 226 1 226 1.5300000000000002e-156 431.0 0 0 0 0 0 0 0 0 0 0 C1_03703 CpxR PHI:4523__PHI:8273__PHI:9363 P0AE88 562 100.0 232 0 0 1 232 1 232 1.5399999999999998e-168 462.0 0 0 0 0 0 0 0 0 0 0 C1_01552 NqrE_(PA2995) PHI:8941 Q9HZL0 287 42.2 199 105 2 1 189 1 199 1.53e-39 132.0 0 0 0 0 0 0 0 0 0 0 C1_01347 CspC PHI:7262 P0A9Y9 28901 100.0 69 0 0 1 69 1 69 1.53e-47 143.0 0 0 0 0 0 0 0 0 0 0 C1_03858 HdfR_(Dda3937_04419) PHI:8567 E0SLG2 204038 63.5 271 95 2 1 271 5 271 1.5400000000000001e-117 337.0 0 0 0 0 0 0 0 0 0 0 C1_00999 XC_2359 PHI:3953 Q4UU61 339 42.0 188 108 1 3 190 2 188 1.54e-46 149.0 AAY49412 Xanthomonas campestris pv. campestris strain 8004 Black rot Eudicots 3726 Raphanus sativus (related: radish) Elongation factor P reduced virulence Gene mutation C1_04457 FtsH PHI:11203 Q6NF92 1717 46.4 610 301 8 6 595 5 608 1.5500000000000002e-166 495.0 0 0 0 0 0 0 0 0 0 0 C1_04080 OmpA PHI:9283__PHI:11127__PHI:11364 Q6RYW5 470 46.4 110 58 1 108 216 226 335 1.55e-20 86.7 0 0 0 0 0 0 0 0 0 0 C1_01806 PaaC PHI:3525__PHI:9578 B4E5A0 95486 45.2 259 126 2 6 248 9 267 1.55e-69 213.0 0 0 0 0 0 0 0 0 0 0 C1_01670 MarA PHI:5369 Q57PB8 28901 95.2 126 6 0 1 126 1 126 1.55e-85 243.0 AAX65443 Salmonella enterica subsp. enterica serovar Choleraesuis strain ATCC13312 Bacteremia Rodents 10090 Mus musculus (related: house mouse) Transcriptional regulator reduced virulence Gene mutation C1_04446 MurA PHI:7630 Q9HVW7 287 60.1 421 165 2 1 418 1 421 1.5600000000000001e-173 490.0 0 0 0 0 0 0 0 0 0 0 C1_02008 Hnr PHI:2679 Q7CQF1 28901 90.8 337 31 0 1 337 1 337 1.5699999999999998e-225 615.0 0 0 0 0 0 0 0 0 0 0 C1_02400 OppF_(bb0335) PHI:7821 H7C7L2 139 49.3 286 139 3 311 590 6 291 1.5699999999999998e-81 258.0 0 0 0 0 0 0 0 0 0 0 C1_04365 B0934 PHI:11546 C0RM94 29459 56.9 341 145 2 1 341 1 339 1.56e-133 382.0 ACO02727 Brucella melitensis M28 Brucellosis Rodents 10090 Mus musculus (related: house mouse) MetQ/NlpA family ABC transporter substrate-binding protein unaffected pathogenicity Gene deletion: full; gene complementation C1_03805 CorA PHI:2479 E1AP33 554 88.6 316 36 0 1 316 1 316 1.57e-203 557.0 0 0 0 0 0 0 0 0 0 0 C1_01685 LsrF PHI:9996 P76143 562 99.3 291 2 0 1 291 1 291 1.57e-211 575.0 0 0 0 0 0 0 0 0 0 0 C1_00116 Bbakr1_(XP_008600433.1) PHI:9444 J4VZT4 176275 42.7 262 141 4 7 261 37 296 1.5899999999999998e-67 210.0 0 0 0 0 0 0 0 0 0 0 C1_00581 BglB PHI:11438 P0C0B9 1314 44.0 291 159 4 9 297 5 293 1.59e-77 236.0 0 0 0 0 0 0 0 0 0 0 C1_00415 STM14_RS15260 PHI:10065 A0A0F6B5Q8 28901 70.5 244 70 1 6 247 22 265 1.5e-128 363.0 ACY89852 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) Hydrogenase maturation peptidase unaffected pathogenicity Gene deletion: full C1_01441 QsvR_(VPA0606) PHI:8742 Q87IK0 670 43.4 53 30 0 219 271 209 261 1.61e-07 49.7 0 0 0 0 0 0 0 0 0 0 C1_02085 YcgE PHI:11409 W9BEV6 573 65.7 242 83 0 1 242 1 242 1.61e-116 331.0 0 0 0 0 0 0 0 0 0 0 C1_00596 GlyA PHI:2962 C5BEV2 67780 87.5 417 52 0 1 417 1 417 1.63e-272 740.0 0 0 0 0 0 0 0 0 0 0 C1_02798 HupB_(XAC1081) PHI:8676 Q8NL12 346 68.9 90 28 0 1 90 1 90 1.64e-38 122.0 0 0 0 0 0 0 0 0 0 0 C1_03032 MetP PHI:11570 R4ZAR0 1311 46.4 151 80 1 15 165 29 178 1.65e-33 118.0 0 0 0 0 0 0 0 0 0 0 C1_02166 PA0423 PHI:3166 Q9I690 287 74.7 190 48 0 1 190 2 191 1.6699999999999998e-104 296.0 AE004479_7 Pseudomonas aeruginosa PAO1 Nosocomial infection Primates 9606 Homo sapiens (related: human) factor responsible for cytotoxicity in lung epithelial cells reduced virulence Biochemical analysis C1_02309 GzOB019 PHI:1579 I1RM25 5518 41.6 77 37 3 196 264 229 305 1.67e-08 55.8 FGSG_05002 Fusarium graminearum GZ3639 Fusarium ear blight Monocots 4564 Triticum (related: wheat) transcription factor unaffected pathogenicity Gene deletion C1_04140 CadC PHI:7387__PHI:11287 Q56405 1639 46.3 67 36 0 8 74 33 99 1.67e-13 60.5 0 0 0 0 0 0 0 0 0 0 C1_04244 PCK1 PHI:424 F5HAA8 5207 46.9 503 251 9 45 538 53 548 1.67e-141 418.0 EAL19243 Cryptococcus neoformans H99 Cryptococcosis Rodents 10090 Mus musculus (related: house mouse) Phosphoenolpyruvate carboxykinase reduced virulence Gene deletion; gene complementation C1_02267 Rmf3 PHI:3676__PHI:3682 D4I0C5 552 78.2 55 12 0 1 55 1 55 1.67e-27 91.7 0 0 0 0 0 0 0 0 0 0 C1_02038 FTT0673p/prsAp PHI:4732 Q5NH02 263 54.1 314 139 4 25 335 4 315 1.68e-120 348.0 CAG45307 Francisella tularensis SCHU S4 Tularemia Rodents 10090 Mus musculus (related: house mouse) ribose phosphate pyrophosphokinase unaffected pathogenicity Gene mutation C1_04215 Gph1__GPH1 PHI:2062__PHI:3815 G4MW66 318829 48.4 820 407 9 8 815 71 886 1.6900000000000002e-266 760.0 0 0 0 0 0 0 0 0 0 0 C1_02485 SdhD PHI:7963 P0AC44 562 100.0 115 0 0 1 115 1 115 1.6900000000000002e-72 209.0 0 0 0 0 0 0 0 0 0 0 C1_01320 PurT PHI:8653 P33221 562 99.2 392 3 0 1 392 1 392 1.6e-280 758.0 0 0 0 0 0 0 0 0 0 0 C1_03893 mC PHI:10209 A0A086ITU0 573 40.3 216 123 4 23 237 6 216 1.6e-48 157.0 0 0 0 0 0 0 0 0 0 0 C1_02034 PrfA_(lmo2543) PHI:9821 Q8Y4A8 1639 50.6 354 171 2 8 358 4 356 1.71e-117 343.0 0 0 0 0 0 0 0 0 0 0 C1_02173 OpgG PHI:5564__PHI:8654 Q9F496 204038 76.2 500 119 0 1 500 23 522 1.72e-296 809.0 0 0 0 0 0 0 0 0 0 0 C1_02513 KdpE PHI:6314 Q48K32 317 52.0 221 106 0 4 224 7 227 1.72e-79 236.0 0 0 0 0 0 0 0 0 0 0 C1_02191 PksI PHI:9106 I6ZFI8 5599 42.6 54 31 0 5 58 1066 1119 1.73e-07 48.1 AFN68300 Alternaria alternata ATCC 66981 Brown spot Eudicots 2706 Citrus (no common name found) Polyketide synthase reduced virulence Gene mutation C1_01359 YeaB PHI:9496 A0A0H3NC59 28901 87.0 192 25 0 1 192 1 192 1.73e-118 332.0 0 0 0 0 0 0 0 0 0 0 C1_01144 HisD_(PXO_00833) PHI:9983 A0A0K0GKU8 347 51.6 426 201 2 6 427 3 427 1.73e-131 384.0 0 0 0 0 0 0 0 0 0 0 C1_03783 TatA PHI:10981 P69428 562 100.0 89 0 0 1 89 1 89 1.73e-53 159.0 0 0 0 0 0 0 0 0 0 0 C1_02352 YbjX PHI:9384 A0A0H2YXK5 562 99.7 328 1 0 1 328 1 328 1.7499999999999998e-239 649.0 0 0 0 0 0 0 0 0 0 0 C1_03385 TamB PHI:10715 D4F0Q2 636 62.9 614 227 1 646 1259 13 625 1.75e-270 776.0 0 0 0 0 0 0 0 0 0 0 C1_00095 MdsABC PHI:6553 Q54001 28901 89.2 492 49 2 1 492 3 490 1.75e-298 812.0 TOLC_SALEN Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Salmonellosis Rodents 10090 Mus musculus (related: house mouse) Multidrug transporter of Salmonella reduced virulence Gene mutation C1_03464 GroEL PHI:3085 P42375 837 62.2 529 199 1 3 530 2 530 1.76e-219 617.0 BAA04222 Porphyromonas gingivalis ATCC 33277 Periodontitis Rodents 10114 Rattus (related: rat) folding of newly synthesized proteins, preventing misfolding and aggregation increased virulence (hypervirulence) Functional test in host: direct injection C1_02516 PotE PHI:9154 P0AAF1 562 100.0 439 0 0 1 439 1 439 1.78e-310 838.0 0 0 0 0 0 0 0 0 0 0 C1_02580 CspE PHI:7263 A0A0F6AYC2 28901 98.6 69 1 0 1 69 1 69 1.79e-46 140.0 0 0 0 0 0 0 0 0 0 0 C1_01197 Inv PHI:6252 Q56889 630 40.4 381 213 5 170 537 69 448 1.79e-81 286.0 CAA88188 Yersinia enterocolitica serotype O:8 Yersiniosis Rodents 10090 Mus musculus (related: house mouse) Invasin reduced virulence Gene mutation C1_03598 MetA PHI:9313 D4I2T4 552 84.5 309 48 0 1 309 1 309 1.7e-199 546.0 0 0 0 0 0 0 0 0 0 0 C1_03154 LeuB PHI:8862 B5F7U8 28901 94.2 363 21 0 1 363 1 363 1.7e-249 677.0 ACH50288 Salmonella enterica subsp. enterica serovar Agona strain Ag 1 Infection Rodents 10090 Mus musculus (related: house mouse) 3-Isopropylmalate dehydrogenase reduced virulence Gene mutation C1_01074 FbaA PHI:6903 P99075 1280 42.2 287 161 3 1 284 1 285 1.7e-69 215.0 BAB43211 Staphylococcus aureus USA300 JE2 White muscardine Moths 7137 Galleria mellonella (related: greater wax moth) Fructose-bisphosphate aldolase reduced virulence Functional test in host: direct injection C1_01977 TonB PHI:6651 P45610 573 69.5 246 56 6 13 246 1 239 1.8000000000000002e-86 255.0 0 0 0 0 0 0 0 0 0 0 C1_03355 ArgF PHI:2634 A0A0H2XHH2 1280 59.0 332 134 2 1 332 1 330 1.81e-136 389.0 0 0 0 0 0 0 0 0 0 0 C1_02205 PutA PHI:7999 Q9I5F6 287 48.6 1042 492 11 95 1116 24 1041 1.81e-310 897.0 0 0 0 0 0 0 0 0 0 0 C1_00291 HopA1 PHI:3165 W0H866 36746 42.8 285 161 1 1 285 3 285 1.81e-74 228.0 0 0 0 0 0 0 0 0 0 0 C1_00860 AccD PHI:10348 Q5HF73 1280 47.3 264 136 1 11 274 17 277 1.8200000000000003e-79 241.0 0 0 0 0 0 0 0 0 0 0 C1_01524 Grx4_(CNAG_02950) PHI:8615 J9VHR2 5207 49.4 87 44 0 14 100 147 233 1.82e-24 91.7 0 0 0 0 0 0 0 0 0 0 C1_04430 HpaP_(XC_1307) PHI:7824 Q4UX47 339 48.4 273 131 4 4 269 1 270 1.84e-86 258.0 0 0 0 0 0 0 0 0 0 0 C1_00373 RaxP_(cysD) PHI:1138 B2SI03 347 67.0 297 98 0 6 302 6 302 1.85e-144 407.0 0 0 0 0 0 0 0 0 0 0 C1_00403 STM14_RS15320 PHI:10077 A0A0F6B5S2 28901 96.7 90 3 0 1 90 1 90 1.85e-62 182.0 ACY89866 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) Hydrogenase formation protein unaffected pathogenicity Gene deletion: full C1_03782 TatB PHI:10982 P69425 562 99.4 171 1 0 1 171 1 171 1.86e-105 297.0 0 0 0 0 0 0 0 0 0 0 C1_02201 EfeB PHI:10992 P31545 562 98.8 423 5 0 1 423 1 423 1.86e-313 844.0 0 0 0 0 0 0 0 0 0 0 C1_01800 PaaD PHI:9579 A0A088UAI6 95486 52.6 133 59 3 9 139 18 148 1.86e-41 133.0 0 0 0 0 0 0 0 0 0 0 C1_04432 YhbH PHI:3674__PHI:3680 D4HUY4 552 82.1 95 17 0 1 95 1 95 1.87e-53 160.0 0 0 0 0 0 0 0 0 0 0 C1_01340 ProQ PHI:8783 P60317 28901 87.9 232 24 2 1 232 1 228 1.88e-127 358.0 AAL20761 Salmonella enterica subsp. enterica serovar Typhimurium strain SL1344 Salmonellosis Primates 9606 Homo sapiens (related: human) RNA chaperone  reduced virulence Gene mutation; gene complementation C1_01310 ZnuC PHI:11007 P0A9X1 562 100.0 251 0 0 1 251 1 251 1.88e-183 501.0 0 0 0 0 0 0 0 0 0 0 C1_03545 SSBX PHI:2737 Q5H2X8 347 56.1 114 46 2 3 116 2 111 1.88e-39 130.0 AAW74693 Xanthomonas oryzae pv. oryzicola strain RS105 Leaf blight Monocots 4530 Oryza sativa (related: rice) Single-stranded DNA-binding protein reduced virulence Gene deletion: full C1_02486 SdhC PHI:7962 P69054 562 100.0 129 0 0 6 134 1 129 1.8900000000000002e-86 246.0 0 0 0 0 0 0 0 0 0 0 C1_02600 PhcA PHI:7611 P52698 305 46.0 63 34 0 11 73 5 67 1.89e-07 50.1 0 0 0 0 0 0 0 0 0 0 C1_01972 Xrp8 PHI:4137 G7TG38 347 53.1 160 75 0 9 168 72 231 1.8e-51 162.0 0 0 0 0 0 0 0 0 0 0 C1_02059 GntR PHI:11407 A6TAW6 573 90.4 239 23 0 1 239 1 239 1.92e-161 444.0 0 0 0 0 0 0 0 0 0 0 C1_03890 LpxA PHI:8042 B2I2B5 470 55.8 450 199 0 7 456 4 453 1.92e-177 503.0 0 0 0 0 0 0 0 0 0 0 C1_02635 CusR_(ABUW_3323) PHI:10397 A0A090B8T6 470 62.2 225 85 0 1 225 1 225 1.93e-102 294.0 0 0 0 0 0 0 0 0 0 0 C1_01085 STM14_3563 PHI:11470 A0A0F6B629 28901 90.9 77 7 0 5 81 1 77 1.96e-42 131.0 ACY89976 Salmonella enterica subsp. enterica serovar Typhimurium strain ATCC 14028s Salmonellosis Rodents 10090 Mus musculus (related: house mouse) Putative transcriptional regulator reduced virulence Gene deletion: full; gene complementation C1_04289 CRP PHI:6616 W9BB63 573 99.5 210 1 0 1 210 1 210 1.97e-151 417.0 AIT00739 Klebsiella pneumoniae K2044 Pneumonia Rodents 10090 Mus musculus (related: house mouse) cAMP receptor protein reduced virulence Gene mutation; gene complementation C1_00301 LysA_(Dda3937_02577) PHI:8581 E0SEI0 204038 73.9 418 109 0 1 418 1 418 1.97e-233 642.0 0 0 0 0 0 0 0 0 0 0 C1_04407 DegQ_(Dda3937_00697) PHI:8575 E0SHD8 204038 70.0 457 134 2 1 455 1 456 1.98e-218 607.0 0 0 0 0 0 0 0 0 0 0 C1_03673 MetB_(Dda3937_03888) PHI:8570 E0SGC8 204038 86.0 385 54 0 1 385 1 385 1.98e-239 654.0 0 0 0 0 0 0 0 0 0 0 C1_00222 CpxA PHI:8050 Q44135 715 52.4 42 20 0 19 60 21 62 1.99e-08 51.2 0 0 0 0 0 0 0 0 0 0 C1_02614 FepD_(VK055_1928) PHI:7483 W9BNM7 573 85.9 333 47 0 1 333 1 333 1.9e-188 521.0 0 0 0 0 0 0 0 0 0 0 C1_04239 GreB PHI:7131 Q8ZLJ2 28901 94.9 157 8 0 1 157 1 157 1e-107 302.0 0 0 0 0 0 0 0 0 0 0 C1_02997 TssC-2__EAMY__3227 PHI:7081__PHI:7443 D4I234 552 44.5 447 247 1 45 490 66 512 1e-142 418.0 0 0 0 0 0 0 0 0 0 0 C1_01145 Prt PHI:5109 B5QZL1 28901 95.7 299 13 0 1 299 1 299 1e-202 554.0 0 0 0 0 0 0 0 0 0 0 C1_01105 BceD PHI:5296 B4EMX6 95486 40.1 147 82 2 1 142 1 146 1e-26 96.3 CAR54715 Burkholderia cenocepacia K56-2 Cystic fibrosis Moths 7137 Galleria mellonella (related: greater wax moth) Protein tyrosine phosphatases reduced virulence Gene mutation C1_00897 NuoJ_(PA2645) PHI:8938 Q9I0J3 287 66.9 163 53 1 1 162 1 163 1e-65 197.0 0 0 0 0 0 0 0 0 0 0 C1_04405 Mdh PHI:2959 C5BF98 67780 83.0 312 53 0 1 312 1 312 2.01e-181 501.0 0 0 0 0 0 0 0 0 0 0 C1_00405 STM14_RS15310 PHI:10075 A0A0F6B5S0 28901 87.0 115 15 0 1 115 1 115 2.02e-74 214.0 ACY89864 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) Hydrogenase nickel incorporation protein unaffected pathogenicity Gene deletion: full C1_01137 WzzST PHI:3728 Q04866 28901 71.1 325 94 0 1 325 1 325 2.0300000000000002e-160 449.0 CAA78946 Salmonella enterica subsp. enterica serovar Typhimurium strain NCTC 12023 Food poisoning Moths 7137 Galleria mellonella (related: greater wax moth) chain length determinant loss of pathogenicity Gene mutation C1_03149 FruR PHI:2672 P0A2P8 28901 98.8 334 4 0 1 334 1 334 2.0499999999999998e-240 652.0 0 0 0 0 0 0 0 0 0 0 C1_02292 PsAAT3 PHI:6261 G4YQK3 67593 41.1 399 229 3 4 396 26 424 2.04e-105 316.0 EGZ30267 Phytophthora sojae race 2 strain P6497 Stem rot (soybean); root rot (soybean) Eudicots 3847 Glycine max (related: soybean) Aspartate aminotransferase reduced virulence Altered gene expression / gene regulation: silencing C1_01896 OvrB_(Z0346) PHI:9508 Q8X6J9 562 40.6 293 172 2 2 294 3 293 2.04e-65 205.0 0 0 0 0 0 0 0 0 0 0 C1_03671 MetF PHI:9325 D4HUG0 552 87.2 296 38 0 1 296 1 296 2.0599999999999998e-197 540.0 0 0 0 0 0 0 0 0 0 0 C1_02620 Fes PHI:4859 P13039 562 98.5 400 6 0 1 400 1 400 2.05e-312 840.0 AAA23757 Escherichia coli serotype O78:K80:H9 strain χ7122 Respiratory disease (poultry); systemic disease (poultry) Birds 9031 Gallus gallus (related: chicken) Catecholate siderophore esterases reduced virulence Gene mutation; gene complementation C1_01319 Eda PHI:11149 Q6D4B5 29471 89.2 212 23 0 1 212 1 212 2.06e-134 374.0 0 0 0 0 0 0 0 0 0 0 C1_01522 SodB PHI:11377 P0A2F4 28901 94.8 193 10 0 1 193 1 193 2.0799999999999999e-140 387.0 0 0 0 0 0 0 0 0 0 0 C1_01389 Dgc PHI:3873 P64825 1773 40.0 115 65 3 347 459 187 299 2.07e-13 70.9 0 0 0 0 0 0 0 0 0 0 C1_00402 STM14_RS15325 PHI:10078 A0A0F6B5S3 28901 94.9 372 19 0 1 372 1 372 2.07e-271 734.0 ACY89867 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) Hydrogenase expression/formation protein unaffected pathogenicity Gene deletion: full C1_00995 MepS PHI:11093 P0AFV4 562 100.0 188 0 0 1 188 1 188 2.08e-133 369.0 AAC75236 Escherichia coli UTI89 Infection Rodents 10090 Mus musculus (related: house mouse) Peptidoglycan DD-endopeptidase/peptidoglycan LD-carboxypeptidase reduced virulence Gene deletion: full; gene complementation C1_03096 YadC PHI:6567 P31058 562 64.2 424 140 4 1 424 1 412 2.08e-187 525.0 0 0 0 0 0 0 0 0 0 0 C1_02424 Rv3111 PHI:7748 P9WJR9 1773 58.5 159 63 2 4 161 8 164 2.08e-50 157.0 0 0 0 0 0 0 0 0 0 0 C1_03077 XC_0892 PHI:3950 Q4UYA7 339 63.6 423 153 1 2 424 4 425 2.09e-194 543.0 AAY47966 Xanthomonas campestris pv. campestris strain 8004 Black rot Eudicots 3726 Raphanus sativus (related: radish) Glutamate-1-semialdehyde aminotransferase reduced virulence Gene mutation C1_02114 Ndh PHI:11248 A0A069PYL4 287 56.9 434 179 4 7 434 4 435 2.1100000000000003e-166 473.0 0 0 0 0 0 0 0 0 0 0 C1_02896 PsCA1 PHI:9599 Q9I730 287 47.3 207 100 2 1 202 22 224 2.11e-61 190.0 0 0 0 0 0 0 0 0 0 0 C1_00831 VacJ PHI:6900 B8F8P8 738 48.6 249 124 3 2 249 3 248 2.12e-76 230.0 0 0 0 0 0 0 0 0 0 0 C1_04387 OadD PHI:8542 Q2KKC1 1351 45.9 61 33 0 95 155 72 132 2.14e-08 48.5 AAX97431 Enterococcus faecalis JH2-2 Nosocomial infection Rodents 10090 Mus musculus (related: house mouse) Biotin acceptor protein reduced virulence Gene deletion: full C1_02987 Ivy PHI:2647 A1A7T3 562 100.0 148 0 0 1 148 10 157 2.14e-104 293.0 0 0 0 0 0 0 0 0 0 0 C1_01687 LsrD PHI:9994 P0AFS1 562 100.0 330 0 0 1 330 1 330 2.1500000000000002e-224 611.0 0 0 0 0 0 0 0 0 0 0 C1_01803 FgEch1_(FGSG_13111) PHI:9517 I1S8D3 5518 41.8 239 137 2 16 252 49 287 2.1599999999999997e-54 175.0 0 0 0 0 0 0 0 0 0 0 C1_03495 PmrA PHI:4497 P36556 28901 90.5 222 21 0 1 222 1 222 2.15e-145 402.0 AAA72365 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Salmonellosis Rodents 10090 Mus musculus (related: house mouse) lipopolysaccharide modification regulator increased virulence (hypervirulence) Gene mutation C1_03571 B0446 PHI:11542 C0RL06 29459 41.4 215 119 3 4 215 3 213 2.1799999999999997e-42 147.0 ACO02289 Brucella melitensis M28 Brucellosis Rodents 10090 Mus musculus (related: house mouse) ABC transporter substrate-binding protein unaffected pathogenicity Gene deletion: full; gene complementation C1_01597 XOC_3249 PHI:9586 G7TB42 347 60.6 99 39 0 4 102 7 105 2.17e-38 123.0 AEQ97343 Xanthomonas oryzae pv. oryzicola strain BLS256 Bacterial leaf streak Monocots 4530 Oryza sativa (related: rice) Membrane protein reduced virulence Gene deletion: full; gene complementation C1_00844 YfcO PHI:6598 P76498 562 46.3 255 125 6 7 255 25 273 2.17e-75 228.0 KU295573 Escherichia coli DE205B Neonatal meningitis Birds 8839 Anas platyrhynchos (related: mallard) reduced virulence Gene deletion: full; gene complementation C1_02140 FlgK PHI:6360 A0A0U1YUA0 553 55.0 549 240 5 1 546 1 545 2.1999999999999998e-190 543.0 0 0 0 0 0 0 0 0 0 0 C1_01345 YobH_(SL1344_1770) PHI:9521 A0A0H3NC74 28901 73.4 79 21 0 1 79 1 79 2.19e-38 120.0 0 0 0 0 0 0 0 0 0 0 C1_02308 HimD PHI:2673 P64394 28901 98.9 94 1 0 1 94 1 94 2.19e-65 190.0 0 0 0 0 0 0 0 0 0 0 C1_01286 CheY PHI:8732__PHI:10049 P0A2D5 28901 97.7 129 3 0 1 129 1 129 2.19e-86 246.0 0 0 0 0 0 0 0 0 0 0 C1_04117 YhjC PHI:11592 Q0SZB7 623 98.8 323 4 0 1 323 1 323 2.1e-232 631.0 0 0 0 0 0 0 0 0 0 0 C1_02607 YbdB PHI:6270 Q8XBU9 562 99.3 137 1 0 1 137 1 137 2.2199999999999998e-101 284.0 0 0 0 0 0 0 0 0 0 0 C1_02426 MoaA PHI:10987 P30745 562 99.4 329 2 0 1 329 1 329 2.2299999999999998e-246 667.0 0 0 0 0 0 0 0 0 0 0 C1_01798 PaaK2 PHI:9584 A0A1V2WCB4 95486 67.5 428 136 3 7 432 11 437 2.22e-211 587.0 0 0 0 0 0 0 0 0 0 0 C1_01312 Ypo2062 PHI:4185 Q0WF94 632 72.8 419 112 2 22 440 1 417 2.22e-225 622.0 0 0 0 0 0 0 0 0 0 0 C1_04283 PpiA PHI:11417 A0A0D6I7L0 28901 95.8 190 8 0 1 190 1 190 2.23e-129 359.0 0 0 0 0 0 0 0 0 0 0 C1_01536 SlyA PHI:2678 P40676 28901 89.4 142 15 0 1 142 1 142 2.23e-84 242.0 0 0 0 0 0 0 0 0 0 0 C1_04305 GzOB039 PHI:1599 I1RZ39 5518 58.4 125 49 2 2 123 53 177 2.2699999999999998e-42 136.0 FGSG_09662 Fusarium graminearum GZ3639 Fusarium ear blight Monocots 4564 Triticum (related: wheat) transcription factor unaffected pathogenicity Gene deletion C1_02128 PKS9__KSA1 PHI:724__PHI:730 I1RSU2 5518 46.9 426 208 6 4 412 2 426 2.2800000000000002e-125 367.0 0 0 0 0 0 0 0 0 0 0 C1_02608 EntA_(VK055_1922) PHI:7485 W9BF24 573 89.9 248 25 0 1 248 14 261 2.28e-156 433.0 0 0 0 0 0 0 0 0 0 0 C1_04241 EnvZ PHI:2686 P08982 28901 95.8 449 19 0 1 449 1 449 2.28e-314 849.0 0 0 0 0 0 0 0 0 0 0 C1_02006 Hns PHI:6369 P0ACF8 562 100.0 137 0 0 1 137 1 137 2.29e-85 244.0 0 0 0 0 0 0 0 0 0 0 C1_00104 QseC PHI:6890__PHI:10174 P40719 562 98.4 449 7 0 1 449 1 449 2.2e-316 854.0 0 0 0 0 0 0 0 0 0 0 C1_03542 RamA_(VK055_1983) PHI:7475 Q48413 573 49.0 100 51 0 5 104 6 105 2.3100000000000002e-33 110.0 0 0 0 0 0 0 0 0 0 0 C1_01499 STM14_RS07730_(ynhG) PHI:10104 A0A0F6B0W9 28901 85.6 334 47 1 1 334 1 333 2.31e-207 568.0 0 0 0 0 0 0 0 0 0 0 C1_04473 CshA__Lmo0866 PHI:6510__PHI:7620 Q8Y8N0 1639 43.7 428 231 3 6 431 2 421 2.34e-111 342.0 0 0 0 0 0 0 0 0 0 0 C1_00880 AckA PHI:9843 A0A0H3Q0Y8 666 73.1 398 103 3 3 399 2 396 2.34e-212 587.0 0 0 0 0 0 0 0 0 0 0 C1_01688 LsrC PHI:9993 P77672 562 99.7 342 1 0 1 342 1 342 2.3599999999999998e-234 637.0 0 0 0 0 0 0 0 0 0 0 C1_00529 SmpB PHI:4218 A1AEE9 562 100.0 160 0 0 1 160 1 160 2.35e-114 319.0 0 0 0 0 0 0 0 0 0 0 C1_04220 GlpD PHI:3272 Q8CWG4 632 77.4 504 111 1 1 501 29 532 2.36e-292 799.0 0 0 0 0 0 0 0 0 0 0 C1_01736 NarW PHI:10518 P19317 562 99.6 231 1 0 1 231 1 231 2.3700000000000003e-167 459.0 0 0 0 0 0 0 0 0 0 0 C1_01498 STM14_RS07725_(ynhA/sufE) PHI:10103 A0A0F6B0W8 28901 87.7 138 17 0 1 138 1 138 2.37e-83 239.0 0 0 0 0 0 0 0 0 0 0 C1_02981 DinJ PHI:6844 Q87CH2 2371 52.9 68 32 0 1 68 1 68 2.38e-20 75.9 0 0 0 0 0 0 0 0 0 0 C1_02097 PotA PHI:6319 Q8DPC2 1313 53.1 288 127 3 16 301 4 285 2.3999999999999998e-91 278.0 0 0 0 0 0 0 0 0 0 0 C1_00735 AdeN PHI:7809 A3M2U3 470 51.7 671 315 4 3 669 5 670 2.39e-232 659.0 0 0 0 0 0 0 0 0 0 0 C1_02828 NrdR PHI:3464 P67320 1314 44.9 147 81 0 1 147 1 147 2.4199999999999998e-42 136.0 0 0 0 0 0 0 0 0 0 0 C1_00626 SseA PHI:609__PHI:616 Q8Z4N6 28901 80.4 280 55 0 1 280 1 280 2.42e-171 473.0 0 0 0 0 0 0 0 0 0 0 C1_01478 XC_3615 PHI:3957 Q4UQL6 339 44.3 122 67 1 190 311 194 314 2.42e-25 101.0 AAY50657 Xanthomonas campestris pv. campestris strain 8004 Black rot Eudicots 3726 Raphanus sativus (related: radish) Electron transfer flavoprotein alpha subunit reduced virulence Gene mutation C1_02754 CopA PHI:5275 B7VKI8 212663 49.6 839 413 5 1 832 116 951 2.42e-259 745.0 0 0 0 0 0 0 0 0 0 0 C1_04066 Bab2_1109 PHI:9129 Q2YJE8 235 59.9 314 125 1 17 330 24 336 2.44e-127 366.0 0 0 0 0 0 0 0 0 0 0 C1_00985 RplY PHI:7469 C6DEJ2 554 69.9 93 28 0 1 93 1 93 2.46e-44 137.0 ACT12677 Pectobacterium carotovorum subsp. carotovorum strain PccS1 Soft rot Eudicots 3711 Brassica rapa (related: field mustard) 50S Ribosomal protein reduced virulence Gene deletion: full; gene complementation C1_00400 AauR PHI:10620 A0A1I5AAS6 317 42.4 356 179 4 345 686 99 442 2.48e-70 234.0 0 0 0 0 0 0 0 0 0 0 C1_01397 SpMsrAB2 PHI:3913 Q04LM6 1313 47.7 132 68 1 4 134 169 300 2.49e-38 130.0 ABJ53896 Streptococcus pneumoniae serotype 2 strain D39 Pneumonia; otitis media; septicemia; meningitis Rodents 10090 Mus musculus (related: house mouse) methionine sulfoxide reductase reduced virulence Gene mutation C1_03086 DksA PHI:6508 P0A1G5 28901 98.7 151 2 0 1 151 1 151 2.4e-105 295.0 AAD01437 Salmonella enterica subsp. enterica serovar Typhimurium Salmonellosis Rodents 10090 Mus musculus (related: house mouse) Response Regulator reduced virulence Gene mutation; gene complementation C1_03444 Orn PHI:6274 P57665 287 67.4 178 58 0 4 181 3 180 2.52e-87 252.0 AE004908_2 Pseudomonas aeruginosa PA14 Opportunistic infection Rodents 10090 Mus musculus (related: house mouse) Oligoribonuclease reduced virulence Gene mutation C1_02807 QoxB PHI:4038 A6QFR9 1280 50.9 623 296 6 29 647 28 644 2.5700000000000003e-215 615.0 0 0 0 0 0 0 0 0 0 0 C1_04250 PA5176 PHI:10783 Q9HU13 287 47.3 182 93 2 6 184 3 184 2.5799999999999996e-54 169.0 AE004930_7 Pseudomonas aeruginosa PAO1161 Infection Nematodes 6239 Caenorhabditis elegans (related: roundworm) Nudix hydrolase domain-containing protein reduced virulence Gene deletion: full; gene complementation C1_04142 Glr1 PHI:4904 C4YR40 5476 48.0 483 212 12 3 449 36 515 2.57e-140 410.0 EEQ46193 Candida albicans Disseminated candidiasis Rodents 10090 Mus musculus (related: house mouse) Glutathione recycling enzymes/ glutathione reductase reduced virulence Gene disruption; gene complementation C1_01233 Flil PHI:6995 Q9I4N1 287 62.4 410 147 1 29 438 29 431 2.58e-172 489.0 AE004540_13 Pseudomonas aeruginosa PA14 Opportunistic infection Rodents 10090 Mus musculus (related: house mouse) Flagellin reduced virulence Gene mutation C1_02220 DnjA_(AFLA_050040_) PHI:9939 B8NSQ3 5059 44.4 63 34 1 5 67 8 69 2.59e-06 47.0 0 0 0 0 0 0 0 0 0 0 C1_04118 STM3124 PHI:8811 Q8ZM32 28901 48.4 64 32 1 138 200 157 220 2.62e-10 56.2 AAL21998 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Salmonellosis Bony fishes 7955 Danio rerio (related: zebrafish) Putative response regulator reduced virulence Gene deletion: full; gene complementation C1_04397 XC_1510 PHI:3952 Q4UWJ5 339 62.6 479 175 1 2 480 5 479 2.62e-205 575.0 AAY48578 Xanthomonas campestris pv. campestris strain 8004 Black rot Eudicots 3726 Raphanus sativus (related: radish) TldD protein, DNA gyrase control? reduced virulence Gene mutation C1_03459 EF-P PHI:6420 P64036 28901 98.9 188 2 0 1 188 1 188 2.6399999999999998e-136 377.0 AAL23157 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Salmonellosis Rodents 10090 Mus musculus (related: house mouse) Elongation factor increased virulence (hypervirulence) Altered gene expression / gene regulation: downregulation C1_01968 TrpB PHI:9321 D4I3E6 552 89.4 395 42 0 3 397 2 396 2.6699999999999997e-263 715.0 0 0 0 0 0 0 0 0 0 0 C1_01465 HmuU PHI:7908 Q66FJ9 633 42.9 282 147 7 52 323 50 327 2.67e-55 181.0 0 0 0 0 0 0 0 0 0 0 C1_00361 Eno PHI:11234 A4VWH9 1307 55.1 430 182 4 1 424 1 425 2.69e-146 422.0 ABP90468 Streptococcus suis CVCC606 Meningitis; septicemia; arthritis; pneumonia (pig) Rodents 10090 Mus musculus (related: house mouse) Enolase unaffected pathogenicity Functional test in host C1_03856 YfiB PHI:7572 W9BJ64 573 76.0 505 121 0 1 505 1 505 2.7000000000000003e-272 747.0 0 0 0 0 0 0 0 0 0 0 C1_04109 PdeC__PdeA PHI:8644__PHI:8642 D4I4B4 552 49.8 648 321 2 2 646 15 661 2.72e-214 612.0 0 0 0 0 0 0 0 0 0 0 C1_02069 PliG PHI:2648 P76002 562 98.5 133 2 0 1 133 1 133 2.73e-91 258.0 0 0 0 0 0 0 0 0 0 0 C1_01012 ANP1 PHI:3793 Q6FM27 5478 46.3 283 147 4 2 280 11 292 2.7400000000000005e-79 242.0 CAG61680 Candida glabrata CBS 138 Disseminated candidiasis Rodents 10090 Mus musculus (related: house mouse) encode alpha -(1-6)-mannosyl-transferases increased virulence (hypervirulence) Gene disruption; gene complementation C1_00432 STM14_RS15195_(srlA) PHI:10052 A0A0F6B5P2 28901 97.3 187 5 0 1 187 1 187 2.74e-133 369.0 0 0 0 0 0 0 0 0 0 0 C1_01995 OppD_(bb0334) PHI:7820 H7C7Q3 139 50.0 264 130 1 15 276 2 265 2.75e-83 252.0 0 0 0 0 0 0 0 0 0 0 C1_00629 XC_2203 PHI:3945 Q4UUL4 339 63.1 141 52 0 1 141 1 141 2.7699999999999998e-61 183.0 AAY49259 Xanthomonas campestris pv. campestris strain 8004 Black rot Eudicots 3726 Raphanus sativus (related: radish) Nucleotide diphosphate kinase reduced virulence Gene mutation C1_00914 ArnF PHI:7955 A6TF94 573 51.6 126 61 0 1 126 1 126 2.7700000000000003e-35 116.0 0 0 0 0 0 0 0 0 0 0 C1_00382 Pimt PHI:6187 Q8ZMF9 28901 94.2 208 12 0 1 208 1 208 2.77e-141 391.0 0 0 0 0 0 0 0 0 0 0 C1_03986 PyrE PHI:7662 P08870 28901 96.2 213 8 0 1 213 1 213 2.77e-148 409.0 0 0 0 0 0 0 0 0 0 0 C1_02510 KdpB PHI:4712 P57698 287 60.3 675 255 5 7 681 28 689 2.78e-257 724.0 0 0 0 0 0 0 0 0 0 0 C1_01248 FliC PHI:7845 Q9K2Y6 562 58.1 616 190 16 1 579 1 585 2.79e-139 415.0 0 0 0 0 0 0 0 0 0 0 C1_00413 STM14_RS15270 PHI:10067 A0A0F6B5R0 28901 90.4 136 13 0 1 136 1 136 2.7e-88 251.0 ACY89854 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) NADH-quinone oxidoreductase subunit unaffected pathogenicity Gene deletion: full C1_01532 SodCII PHI:9809__PHI:11379 O68901 28901 82.1 173 31 0 1 173 1 173 2.8199999999999998e-101 287.0 0 0 0 0 0 0 0 0 0 0 C1_02466 OmpA1 PHI:3937 D2UB90 29447 40.5 84 49 1 71 153 254 337 2.81e-12 62.0 CBA15086 Xanthomonas albilineans XaFL07-1 Leaf scald Monocots 4547 Saccharum officinarum (related: sugarcane) putative ompa family outer membrane protein precursor reduced virulence Gene mutation: characterised; gene complementation C1_01782 Trg PHI:6982 A0A0F6B1Q1 28901 69.1 521 161 0 6 526 10 530 2.8200000000000004e-179 514.0 0 0 0 0 0 0 0 0 0 0 C1_00969 NapB PHI:10525 P0ABL3 562 99.3 149 1 0 1 149 1 149 2.82e-112 313.0 0 0 0 0 0 0 0 0 0 0 C1_03053 PA3646 PHI:3784 Q9HXY6 287 46.3 335 180 0 3 337 6 340 2.8300000000000002e-77 239.0 AE004784_7 Pseudomonas aeruginosa PAO1 Infection Beetles 7067 Tenebrio molitor (related: yellow mealworm) acyltransferases reduced virulence Altered gene expression / gene regulation: overexpression C1_03190 HK2_(BB0763) PHI:10875 A0A0H3LHY6 139 42.1 254 138 6 9 261 15 260 2.83e-55 177.0 0 0 0 0 0 0 0 0 0 0 C1_02468 TolA PHI:3472 Q8X965 562 93.7 395 24 1 1 395 1 394 2.8599999999999997e-113 335.0 AAG55075 Escherichia coli TW14359 Infection Moths 7137 Galleria mellonella (related: greater wax moth) Periplasm spanning protein reduced virulence Gene mutation; gene complementation C1_00374 RaxQ PHI:1139 B2SI02 347 54.2 397 181 1 36 432 1 396 2.8699999999999997e-150 439.0 0 0 0 0 0 0 0 0 0 0 C1_04134 Slp PHI:9256 P37194 562 99.5 188 1 0 1 188 1 188 2.86e-140 387.0 0 0 0 0 0 0 0 0 0 0 C1_04240 OmpR PHI:11693 P0AA16 562 100.0 239 0 0 1 239 1 239 2.88e-172 472.0 0 0 0 0 0 0 0 0 0 0 C1_04286 XC_0481 PHI:3941 Q4UZG1 339 60.4 192 71 1 1 187 1 192 2.88e-81 238.0 AAY47562 Xanthomonas campestris pv. campestris strain 8004 Black rot Eudicots 3726 Raphanus sativus (related: radish) Anthranilate synthase component II reduced virulence Gene mutation C1_02168 LpxL1_(BN49_2155) PHI:7946 W9BFU2 573 86.3 306 42 0 1 306 1 306 2.9000000000000004e-210 573.0 0 0 0 0 0 0 0 0 0 0 C1_04538 IagB PHI:636 P43018 28901 41.9 124 70 2 33 156 21 142 2.91e-25 93.6 0 0 0 0 0 0 0 0 0 0 C1_00323 AmiC PHI:10980 P63883 562 100.0 417 0 0 1 417 1 417 2.9500000000000002e-291 788.0 0 0 0 0 0 0 0 0 0 0 C1_01927 AldA_(PSPTO_0092) PHI:7787 Q88BC5 317 58.3 489 200 1 9 493 9 497 2.96e-202 569.0 0 0 0 0 0 0 0 0 0 0 C1_03838 EpsC PHI:7052 Q8DTB7 1309 51.1 370 172 2 1 369 4 365 2.9700000000000002e-123 359.0 0 0 0 0 0 0 0 0 0 0 C1_02598 AhpC PHI:11383 P0A251 28901 98.4 187 3 0 1 187 1 187 2.97e-137 379.0 0 0 0 0 0 0 0 0 0 0 C1_02895 GzLam001 PHI:1532 I1RTF5 5518 43.4 136 76 1 22 156 29 164 2.97e-26 95.9 FGSG_07458 Fusarium graminearum GZ3639 Fusarium ear blight Monocots 4564 Triticum (related: wheat) transcription factor unaffected pathogenicity Gene deletion C1_04454 GreA PHI:7130 P64281 28901 96.8 158 5 0 1 158 1 158 2.98e-107 301.0 0 0 0 0 0 0 0 0 0 0 C1_00472 Sdh1 PHI:3914 Q0V515 13684 55.6 482 205 3 3 481 8 483 2.98e-190 538.0 EAT92394 Parastagonospora nodorum SN15 Stagonospora nodorum blotch Monocots 4565 Triticum aestivum (related: bread wheat) encodes succinic semialdehyde dehydrogenase reduced virulence Gene disruption; gene complementation C1_01135 Bcpgd PHI:9835 A0A384JMC8 40559 49.4 451 224 3 7 454 11 460 3.02e-154 446.0 0 0 0 0 0 0 0 0 0 0 C1_01206 YedX PHI:2651 Q8ZQ52 28901 68.4 136 43 0 2 137 1 136 3.0399999999999996e-67 198.0 0 0 0 0 0 0 0 0 0 0 C1_02467 TolB PHI:10905 D2TPE2 67825 97.0 430 13 0 1 430 1 430 3.0399999999999997e-207 576.0 0 0 0 0 0 0 0 0 0 0 C1_00407 STM14_RS15300 PHI:10073 A0A0F6B5R6 28901 95.5 202 9 0 1 202 1 202 3.03e-140 388.0 ACY89860 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) Formate hydrogenlyase regulator unaffected pathogenicity Gene deletion: full C1_03212 DnaJ PHI:10485 Q9HV44 287 62.5 379 135 2 1 374 1 377 3.04e-149 425.0 0 0 0 0 0 0 0 0 0 0 C1_00917 ArnD PHI:7952 A6TF97 573 67.8 295 92 1 1 292 1 295 3.0500000000000002e-148 416.0 0 0 0 0 0 0 0 0 0 0 C1_01207 CovR PHI:4198__PHI:4846 B3VA60 1314 41.8 220 123 2 39 253 4 223 3.0599999999999997e-52 168.0 0 0 0 0 0 0 0 0 0 0 C1_02103 Cob PHI:5572 P0A2F2 28901 91.2 273 24 0 1 273 1 273 3.06e-184 505.0 0 0 0 0 0 0 0 0 0 0 C1_02349 CspD_(_WP_003488188.1) PHI:8639 A0A0K0GLJ4 347 63.2 68 25 0 1 68 1 68 3.0899999999999998e-28 94.7 0 0 0 0 0 0 0 0 0 0 C1_00430 STM14_RS15205_(slrB) PHI:10054 A0A0F6B5P4 28901 81.4 118 22 0 1 118 1 118 3.09e-69 202.0 0 0 0 0 0 0 0 0 0 0 C1_02679 STM14_RS07800_(orf319) PHI:10119 A0A0F6B0Y3 28901 68.6 318 100 0 1 318 1 318 3.1299999999999997e-170 473.0 0 0 0 0 0 0 0 0 0 0 C1_01142 HisB PHI:7790 G7TE30 347 52.2 372 155 3 6 355 5 375 3.1300000000000002e-133 383.0 AEQ96355 Xanthomonas oryzae pv. oryzicola strain RS105 Bacterial blight (rice) Monocots 4530 Oryza sativa (related: rice) Bifunctional enzyme implicated in the imidazoleglycerol-phosphate dehydratase activity reduced virulence Gene deletion: full; gene complementation C1_00401 STM14_RS15330 PHI:10079 A0A0F6B5S4 28901 92.0 336 27 0 1 336 1 336 3.13e-220 601.0 ACY89868 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) Formate hydrogenlyase transcriptional activator unaffected pathogenicity Gene deletion: full C1_00616 IscR PHI:6895 Q7CQ10 28901 97.0 164 3 1 1 162 1 164 3.16e-109 306.0 0 0 0 0 0 0 0 0 0 0 C1_04132 MgtC PHI:3593 B2HSV6 1781 43.4 113 53 4 3 114 7 109 3.16e-20 84.0 ACC41130 Mycobacterium marinum M Opportunistic infection Bony fishes 7955 Danio rerio (related: zebrafish) intramacrophage growth/Mg2+ transport p-type ATPase unaffected pathogenicity Gene deletion: full; gene complementation C1_02002 AdhE PHI:8932 A0A116Q7Z1 1307 46.8 869 435 12 9 864 20 874 3.16e-256 736.0 0 0 0 0 0 0 0 0 0 0 C1_02215 Bab1_1070 PHI:9134 Q2YQ23 235 57.0 200 83 3 1 198 1 199 3.1799999999999996e-68 205.0 0 0 0 0 0 0 0 0 0 0 C1_02546 PA3984 PHI:3782 Q9ZI86 287 40.0 508 282 13 15 512 13 507 3.17e-98 304.0 AAC97167 Pseudomonas aeruginosa PAO1 Infection Beetles 7067 Tenebrio molitor (related: yellow mealworm) acyltransferases reduced virulence Altered gene expression / gene regulation: overexpression C1_00545 YfiR PHI:7570 W9BND0 573 60.0 165 63 1 5 169 13 174 3.18e-66 198.0 0 0 0 0 0 0 0 0 0 0 C1_02444 ModA10 PHI:5422 P45323 727 51.2 246 118 2 13 257 10 254 3.18e-76 230.0 0 0 0 0 0 0 0 0 0 0 C1_01188 PccS1_004012 PHI:10584 C6D9H7 554 77.8 90 20 0 1 90 1 90 3.1999999999999996e-42 139.0 ACT13704 Pectobacterium carotovorum subsp. carotovorum strain PccS1 Soft rot Monocots 69721 Zantedeschia aethiopica (related: arum-lily) LysR family transcriptional regulator, partial unaffected pathogenicity Gene deletion: full; gene complementation C1_04348 DprA PHI:11059 Q8DPI7 1313 44.1 204 112 2 82 285 81 282 3.19e-43 150.0 0 0 0 0 0 0 0 0 0 0 C1_04007 RfaC PHI:9594 P26469 28901 83.5 316 52 0 1 316 1 316 3.1e-195 536.0 0 0 0 0 0 0 0 0 0 0 C1_03631 TufA PHI:10282 W8TRT9 1280 75.1 393 98 0 1 393 1 393 3.2000000000000002e-226 621.0 0 0 0 0 0 0 0 0 0 0 C1_00886 AspC_(PXO_02420) PHI:9989 A0A0K0GPI8 347 43.0 398 227 0 3 400 8 405 3.2699999999999998e-111 331.0 0 0 0 0 0 0 0 0 0 0 C1_02657 GpT PHI:3319 B8F4F0 738 59.6 47 19 0 730 776 784 830 3.28e-09 58.9 0 0 0 0 0 0 0 0 0 0 C1_03764 MobA PHI:5304 Q4QM57 727 40.3 186 109 1 6 189 4 189 3.2e-45 146.0 0 0 0 0 0 0 0 0 0 0 C1_01257 SirA PHI:560 P96058 28901 96.3 218 8 0 1 218 1 218 3.34e-147 407.0 0 0 0 0 0 0 0 0 0 0 C1_02015 NarJ PHI:10514 P0AF26 562 98.3 236 4 0 1 236 1 236 3.34e-165 454.0 0 0 0 0 0 0 0 0 0 0 C1_03882 AtpB PHI:9436 A0A0F6B941 28901 96.3 271 10 0 1 271 1 271 3.34e-187 512.0 0 0 0 0 0 0 0 0 0 0 C1_01349 YebN PHI:7899 G1BJ13 347 53.0 183 82 1 7 185 7 189 3.34e-59 182.0 0 0 0 0 0 0 0 0 0 0 C1_00847 AroB PHI:7654 Q4WJ77 746128 44.5 384 178 5 4 352 2 385 3.34e-96 290.0 0 0 0 0 0 0 0 0 0 0 C1_00383 NlpD PHI:9369 Q7CKC8 632 57.4 387 103 7 1 379 1 333 3.35e-136 390.0 0 0 0 0 0 0 0 0 0 0 C1_03230 CreB PHI:11268 Q8ZJU6 28901 84.3 229 36 0 1 229 1 229 3.36e-141 392.0 0 0 0 0 0 0 0 0 0 0 C1_03227 ArcA PHI:6532 P0A9Q1 562 100.0 238 0 0 1 238 1 238 3.38e-175 479.0 0 0 0 0 0 0 0 0 0 0 C1_04071 AtaT PHI:11169 P37669 562 99.7 331 1 0 1 331 1 331 3.4099999999999996e-242 656.0 0 0 0 0 0 0 0 0 0 0 C1_01162 RadC PHI:4701 B2IQ18 1313 43.0 100 57 0 55 154 127 226 3.4399999999999997e-23 89.7 0 0 0 0 0 0 0 0 0 0 C1_00310 PA0336_(RppH) PHI:7474 Q9X4P2 287 67.8 152 49 0 1 152 1 152 3.43e-79 231.0 0 0 0 0 0 0 0 0 0 0 C1_02937 Inv PHI:3781 D0ZEM2 636 41.3 455 245 6 80 518 178 626 3.46e-102 342.0 0 0 0 0 0 0 0 0 0 0 C1_00955 RcsD PHI:2501 D4HWX6 552 53.0 887 399 8 11 890 5 880 3.46e-311 877.0 0 0 0 0 0 0 0 0 0 0 C1_00428 STM14_RS15215_(gutM) PHI:10056 A0A0F6B5P6 28901 83.2 119 20 0 1 119 1 119 3.46e-67 196.0 0 0 0 0 0 0 0 0 0 0 C1_03532 NrfC PHI:10999 P0AAK7 562 100.0 223 0 0 1 223 1 223 3.4e-172 470.0 0 0 0 0 0 0 0 0 0 0 C1_01002 PtsH PHI:11269 P99143 1280 43.0 79 42 1 290 368 6 81 3.55e-13 63.2 0 0 0 0 0 0 0 0 0 0 C1_01686 LsrB PHI:9995 P76142 562 98.8 340 4 0 1 340 1 340 3.55e-244 662.0 0 0 0 0 0 0 0 0 0 0 C1_01655 VK055_1961 PHI:7511 A0A076ZHT9 573 49.2 248 122 3 3 247 1 247 3.5800000000000004e-79 237.0 AIK80567 Klebsiella pneumoniae KPPR1 Pneumonia Rodents 10090 Mus musculus (related: house mouse) Serine 3-dehydrogenase unaffected pathogenicity Gene deletion: full C1_04012 Cps2J PHI:4130__PHI:6140 A4VTV0 1307 42.0 112 65 0 7 118 3 114 3.58e-23 96.7 0 0 0 0 0 0 0 0 0 0 C1_00731 PtsH PHI:9311 D4HXP5 552 95.3 85 4 0 1 85 1 85 3.59e-51 153.0 0 0 0 0 0 0 0 0 0 0 C1_03752 NtrB PHI:11699 Q9HU60 287 47.3 347 173 5 12 349 10 355 3.5e-101 301.0 0 0 0 0 0 0 0 0 0 0 C1_01664 Cel-EIIB_(SAG0329) PHI:8620 Q8E1M5 1311 41.0 105 55 3 1 102 1 101 3.5e-15 63.9 0 0 0 0 0 0 0 0 0 0 C1_04039 PPECC33_0249_(Rhs1) PHI:11588 A0A1B2RBP7 562 46.2 106 52 3 1147 1250 1148 1250 3.61e-18 89.4 0 0 0 0 0 0 0 0 0 0 C1_01356 PSPTO_2691 PHI:3118 Q882D7 317 52.3 239 108 3 1 233 1 239 3.62e-75 236.0 AAO56193 Pseudomonas syringae pv. tomato strain DC3000 Bacterial speck (tomato) Eudicots 4081 Solanum lycopersicum (related: tomato) Membrane protein, TerC family unaffected pathogenicity Gene mutation C1_01807 PaaB PHI:3170 B4E5A1 95486 65.6 93 32 0 3 95 2 94 3.64e-44 136.0 0 0 0 0 0 0 0 0 0 0 C1_00446 GshA PHI:9280__PHI:11327 Q9HTY6 287 44.4 475 244 8 25 494 27 486 3.65e-128 382.0 0 0 0 0 0 0 0 0 0 0 C1_00193 PilT PHI:6363 A0A0U1YU79 553 60.1 328 127 1 1 324 1 328 3.65e-131 375.0 0 0 0 0 0 0 0 0 0 0 C1_03786 UbiE PHI:10294 W8TW76 1280 41.7 228 130 1 23 250 9 233 3.65e-57 181.0 0 0 0 0 0 0 0 0 0 0 C1_00404 STM14_RS15315 PHI:10076 A0A0F6B5S1 28901 94.5 290 16 0 1 290 1 290 3.66e-205 559.0 ACY89865 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) Hydrogenase assembly chaperone unaffected pathogenicity Gene deletion: full C1_03175 RsmA PHI:10573 C6DEY6 554 79.8 272 55 0 1 272 1 272 3.72e-155 431.0 0 0 0 0 0 0 0 0 0 0 C1_03474 ToxR PHI:701__PHI:6217__PHI:7777__PHI:11032 P15795 666 40.2 122 62 5 30 145 51 167 3.73e-11 62.4 0 0 0 0 0 0 0 0 0 0 C1_00163 ExeD PHI:11440 P31780 644 49.1 645 286 10 19 647 4 622 3.73e-193 560.0 0 0 0 0 0 0 0 0 0 0 C1_02448 GalE PHI:9264 P24325 727 57.7 338 143 0 1 338 1 338 3.7599999999999996e-138 394.0 0 0 0 0 0 0 0 0 0 0 C1_01502 STM14_RS07795_(orf70) PHI:10118 A0A0F6B0Y2 28901 87.0 69 9 0 1 69 1 69 3.7600000000000004e-37 117.0 0 0 0 0 0 0 0 0 0 0 C1_04431 PtsN PHI:3133 Q665I9 633 86.2 152 21 0 4 155 3 154 3.7999999999999994e-89 255.0 0 0 0 0 0 0 0 0 0 0 C1_03118 PdhR PHI:3135 Q66EI1 633 86.2 253 35 0 1 253 1 253 3.79e-148 412.0 0 0 0 0 0 0 0 0 0 0 C1_02778 TomB PHI:11220 A0A0F7J4C9 28901 95.2 124 6 0 1 124 1 124 3.8399999999999996e-89 252.0 0 0 0 0 0 0 0 0 0 0 C1_01484 AroD PHI:7062 A0A0U1GNF3 28901 80.6 252 49 0 1 252 1 252 3.8399999999999997e-140 392.0 0 0 0 0 0 0 0 0 0 0 C1_01367 FadD PHI:4108 A5F6S0 666 71.5 562 159 1 23 583 1 562 3.85e-295 811.0 0 0 0 0 0 0 0 0 0 0 C1_03483 SlnCl1_(GU907087) PHI:8857 D5LHI2 290576 40.0 70 36 1 472 535 829 898 3.87e-06 48.1 0 0 0 0 0 0 0 0 0 0 C1_04489 RsmI PHI:4960 A0A0H3JLK2 1280 48.9 227 115 1 14 240 4 229 3.88e-61 193.0 0 0 0 0 0 0 0 0 0 0 C1_01921 PspC PHI:7659 A0A0F6B1W9 28901 84.0 119 19 0 1 119 1 119 3.88e-64 189.0 0 0 0 0 0 0 0 0 0 0 C1_01758 LacA PHI:3526 D3QJB2 28901 44.0 50 28 0 47 96 134 183 3.89e-07 46.2 0 0 0 0 0 0 0 0 0 0 C1_03761 DsbA_(ROD_38991) PHI:8691 D2TUX9 67825 87.0 208 26 1 1 208 1 207 3.9099999999999997e-134 373.0 0 0 0 0 0 0 0 0 0 0 C1_02481 OdhB PHI:7353 Q2FH26 1280 42.2 434 202 9 5 404 3 421 3.9399999999999994e-95 290.0 0 0 0 0 0 0 0 0 0 0 C1_03156 LeuD PHI:8965 W9BQ45 573 88.1 201 24 0 1 201 1 201 3.95e-133 370.0 0 0 0 0 0 0 0 0 0 0 C1_02544 YbeY PHI:7671 A1JQ74 630 79.4 155 32 0 1 155 1 155 3.95e-86 247.0 0 0 0 0 0 0 0 0 0 0 C1_00618 IscU PHI:6892 A0A0L9JQ40 28901 98.4 128 2 0 1 128 1 128 3e-88 250.0 0 0 0 0 0 0 0 0 0 0 C1_02130 FabG1 PHI:5271 Q8Y0J2 305 64.3 244 84 1 3 243 5 248 3e-99 288.0 0 0 0 0 0 0 0 0 0 0 C1_01288 FlhB PHI:11174 P76299 562 99.5 382 2 0 1 382 1 382 4.0000000000000005e-269 729.0 0 0 0 0 0 0 0 0 0 0 C1_01255 RhlR PHI:7289 A0A0H2ZEG8 287 40.8 238 141 0 3 240 4 241 4.0300000000000004e-56 177.0 ABJ12732 Pseudomonas aeruginosa UCBPP-PA14 Opportunistic infection Nematodes 6239 Caenorhabditis elegans (related: roundworm) LuxI/R Quorum-sensing systems loss of pathogenicity Gene deletion: full C1_03065 Map PHI:9334 D2TI55 67825 89.8 264 27 0 1 264 1 264 4.03e-180 494.0 0 0 0 0 0 0 0 0 0 0 C1_01568 FumC PHI:10048 Q8ZPL7 28901 91.6 467 39 0 1 467 1 467 4.06e-312 845.0 0 0 0 0 0 0 0 0 0 0 C1_01278 MotA PHI:6533 P09348 562 99.7 295 1 0 1 295 1 295 4.0700000000000005e-200 547.0 0 0 0 0 0 0 0 0 0 0 C1_01516 CFAS PHI:2643 A4HTK3 5671 49.4 395 176 6 1 371 81 475 4.07e-127 373.0 CAM65755 Leishmania infantum JPCM5 Leishmaniasis Rodents 10090 Mus musculus (related: house mouse) Cyclopropane fatty acid synthetase reduced virulence Gene deletion: full; gene complementation C1_03855 MoIlv2 PHI:3975 G4MMK2 318829 43.7 568 280 12 14 544 95 659 4.08e-140 419.0 EHA56980 Magnaporthe oryzae Guy11 Blast (rice) Monocots 4530 Oryza sativa (related: rice) Acetolactate synthases loss of pathogenicity Gene disruption; gene complementation C1_03123 PilA PHI:6362 A0A0U1YU94 553 61.1 144 55 1 1 144 1 143 4.08e-59 178.0 0 0 0 0 0 0 0 0 0 0 C1_03494 Mcr-3 PHI:11670 A0A2R2ZJD0 562 40.7 496 289 3 52 545 65 557 4.13e-143 422.0 0 0 0 0 0 0 0 0 0 0 C1_02801 ClpP PHI:3040 P0A1D7 28901 99.0 207 2 0 1 207 1 207 4.13e-147 405.0 BAA94668 Salmonella enterica subsp. enterica serovar Typhimurium strain C5 Food poisoning Rodents 10090 Mus musculus (related: house mouse) proteolytic component reduced virulence Gene deletion: full; gene complementation C1_03232 BfvR_(YPO1737) PHI:8505 Q7CHU5 632 41.0 105 62 0 2 106 5 109 4.14e-22 87.8 0 0 0 0 0 0 0 0 0 0 C1_01285 CheB PHI:6461 P04042 28901 95.4 349 16 0 1 349 1 349 4.24e-236 642.0 0 0 0 0 0 0 0 0 0 0 C1_02328 RarA PHI:6447 A0A164J6A6 573 95.7 447 19 0 1 447 1 447 4.24e-313 845.0 0 0 0 0 0 0 0 0 0 0 C1_03110 SpeE PHI:9153 P09158 562 100.0 288 0 0 1 288 1 288 4.2e-219 594.0 0 0 0 0 0 0 0 0 0 0 C1_01648 Z3917 PHI:6736 Q8X415 562 95.5 22 1 0 145 166 7 28 4.35e-06 40.4 AE005492_1 Escherichia coli EDL933 Urinary tract infection Nematodes 6239 Caenorhabditis elegans (related: roundworm) increased virulence (hypervirulence) Gene mutation; gene complementation C1_01283 McpB PHI:6985 A0A0F6B6S3 28901 44.8 268 146 2 158 424 158 424 4.37e-36 139.0 0 0 0 0 0 0 0 0 0 0 C1_00916 ArnT PHI:7953 A6TF96 573 63.5 551 200 1 1 550 1 551 4.39e-251 697.0 0 0 0 0 0 0 0 0 0 0 C1_03762 RdoA_(ROD_39001) PHI:8692 D2TUY0 67825 85.1 328 49 0 1 328 1 328 4.4299999999999996e-216 590.0 0 0 0 0 0 0 0 0 0 0 C1_03780 PsTatD4 PHI:3071 G4Z2B4 67593 40.1 177 94 4 1 168 58 231 4.44e-34 122.0 EGZ19258 Phytophthora sojae race 2 strain P6497 Stem rot (soybean) Eudicots 3847 Glycine max (related: soybean) nuclease reduced virulence Altered gene expression / gene regulation: overexpression C1_04207 GntK PHI:6701 A0A0H6FRN3 666 45.6 90 48 1 84 173 1 89 4.4799999999999997e-23 86.3 0 0 0 0 0 0 0 0 0 0 C1_04162 NikR_(bab2_0432) PHI:9061 Q2YJ35 235 50.4 131 64 1 1 130 1 131 4.4e-44 139.0 0 0 0 0 0 0 0 0 0 0 C1_03429 PurA PHI:2625__PHI:9416 P65882 28901 99.5 432 2 0 1 432 1 432 4.53e-320 862.0 0 0 0 0 0 0 0 0 0 0 C1_00034 DedA PHI:11405 W9B383 573 92.3 220 17 0 1 220 1 220 4.54e-146 404.0 0 0 0 0 0 0 0 0 0 0 C1_00429 STM14_RS15210_(srlD) PHI:10055 A0A0F6B5P5 28901 97.7 259 6 0 1 259 1 259 4.5500000000000005e-179 491.0 0 0 0 0 0 0 0 0 0 0 C1_00915 ArnE PHI:7954 A6TF95 573 65.5 110 38 0 2 111 3 112 4.5599999999999997e-48 147.0 0 0 0 0 0 0 0 0 0 0 C1_02617 FepE PHI:9093 Q8ZR36 28901 73.2 373 99 1 1 373 1 372 4.59e-192 533.0 0 0 0 0 0 0 0 0 0 0 C1_02206 FasR PHI:10876 O05858 1773 40.7 54 32 0 19 72 40 93 4.5e-06 44.3 0 0 0 0 0 0 0 0 0 0 C1_02779 Hha PHI:11219 Q7CR17 28901 98.6 72 1 0 1 72 1 72 4.6199999999999994e-48 144.0 0 0 0 0 0 0 0 0 0 0 C1_00636 MnmE PHI:9270__PHI:11090 A4VWD1 1307 41.0 134 74 2 203 336 224 352 4.6200000000000005e-21 94.0 0 0 0 0 0 0 0 0 0 0 C1_00197 GshB PHI:9281 Q9I697 287 65.1 312 109 0 2 313 3 314 4.63e-145 409.0 0 0 0 0 0 0 0 0 0 0 C1_00965 NapD PHI:10521 P0A9I5 562 100.0 87 0 0 1 87 1 87 4.6400000000000004e-57 168.0 0 0 0 0 0 0 0 0 0 0 C1_00288 NlpD_(XC_2522) PHI:7780 A0A0H2X8G8 339 44.2 208 107 3 39 243 63 264 4.6599999999999994e-46 153.0 0 0 0 0 0 0 0 0 0 0 C1_03070 DegP_(ROD_01651) PHI:8690 D2TI49 67825 94.3 474 24 1 1 474 1 471 4.6799999999999995e-307 832.0 0 0 0 0 0 0 0 0 0 0 C1_04163 B0779 PHI:11545 C0RLV2 29459 53.3 261 122 0 1 261 1 261 4.67e-89 263.0 ACO02585 Brucella melitensis M28 Brucellosis Rodents 10090 Mus musculus (related: house mouse) ABC transporter substrate-binding protein unaffected pathogenicity Gene deletion: full; gene complementation C1_02842 PhoB PHI:8032 Q5GWK1 347 59.0 227 93 0 1 227 1 227 4.69e-97 281.0 AAW76920 Xanthomonas oryzae pv. oryzae strain PXO99A Bacterial leaf blight Monocots 4530 Oryza sativa (related: rice) Two-component signal transduction system response regulator unaffected pathogenicity Gene deletion: full C1_01580 MdtI PHI:8967 B5XR94 573 84.4 109 17 0 1 109 1 109 4.6e-65 190.0 0 0 0 0 0 0 0 0 0 0 C1_01189 PccS1_002702 PHI:10578 C6DD61 554 70.3 317 93 1 1 316 1 317 4.719999999999999e-159 445.0 ACT12440 Pectobacterium carotovorum subsp. carotovorum strain PccS1 Soft rot Monocots 69721 Zantedeschia aethiopica (related: arum-lily) Transcriptional regulator, LysR family unaffected pathogenicity Gene deletion: full; gene complementation C1_01903 TyrR PHI:4563 Q0WEH7 632 70.6 517 144 2 1 510 1 516 4.72e-263 725.0 CAL20972 Yersinia pestis 201 Plague Rodents 10090 Mus musculus (related: house mouse) regulator of aromatic amino acid metabolism reduced virulence Gene deletion: full; gene complementation C1_02583 PXO_RS05400 PHI:9021 A0A0K0GHV7 347 40.2 82 43 2 32 109 183 262 4.76e-06 44.7 Xanthomonas oryzae pv. oryzae strain PXO99A Bacterial leaf blight Monocots 4530 Oryza sativa (related: rice) Response regulator unaffected pathogenicity Gene mutation C1_04279 NirC PHI:3597 P0AC26 562 100.0 268 0 0 1 268 1 268 4.83e-199 542.0 CAA32418 Escherichia coli APEC strain SCI-07 Colibacillosis Birds 9031 Gallus gallus (related: chicken) Nitrite transporter reduced virulence Gene mutation; gene complementation C1_04076 CspA PHI:7637 P0A355 1639 68.9 61 18 1 7 67 4 63 4.83e-26 89.0 CAA62903 Listeria monocytogenes EGD-e Listeriosis Bony fishes 7955 Danio rerio (related: zebrafish) Cold shock protein reduced virulence Gene mutation C1_03649 OxyR PHI:3714 C8TZQ2 562 100.0 305 0 0 1 305 1 305 4.91e-222 603.0 BAI33414 Escherichia coli UCB34 (O17:K+:H18) Urinary tract infection Rodents 10090 Mus musculus (related: house mouse) oxidative stress response regulator reduced virulence Gene mutation; gene complementation C1_04333 SecY PHI:5257 Q8Y448 1639 41.5 427 236 7 16 434 11 431 4.92e-106 319.0 0 0 0 0 0 0 0 0 0 0 C1_02737 VtlR PHI:5012 Q2YRP4 235 42.2 83 48 0 3 85 6 88 4.93e-10 57.8 0 0 0 0 0 0 0 0 0 0 C1_00060 Aer PHI:6979 A0A0F6B6Z9 28901 80.4 506 99 0 1 506 1 506 4.9499999999999995e-242 671.0 0 0 0 0 0 0 0 0 0 0 C1_03886 AtpA PHI:10773 Q2FWE8 1280 53.7 512 224 3 1 512 1 499 4.96e-182 518.0 0 0 0 0 0 0 0 0 0 0 C1_00431 STM14_RS15200_(srlE) PHI:10053 A0A0F6B5P3 28901 92.3 323 21 2 1 319 1 323 4.96e-214 584.0 0 0 0 0 0 0 0 0 0 0 C1_02181 VraR PHI:7986 A0A0Z9GQC2 1307 54.5 55 25 0 156 210 148 202 4.97e-09 52.8 0 0 0 0 0 0 0 0 0 0 C1_04477 YhbU PHI:11411 A0A0W8AWM7 573 97.6 331 8 0 1 331 1 331 5.05e-244 661.0 0 0 0 0 0 0 0 0 0 0 C1_00964 NapF PHI:10520 P0AAL0 562 99.4 164 1 0 1 164 1 164 5.1100000000000005e-129 356.0 0 0 0 0 0 0 0 0 0 0 C1_02160 PyrC PHI:9307 D4I0W8 552 71.8 348 96 1 1 346 1 348 5.13e-184 511.0 0 0 0 0 0 0 0 0 0 0 C1_00877 PA4841 PHI:10782 Q9HUW9 287 40.1 167 98 1 1 165 1 167 5.14e-35 119.0 AE004897_4 Pseudomonas aeruginosa PAO1161 Infection Nematodes 6239 Caenorhabditis elegans (related: roundworm) Nudix hydrolase domain-containing protein unaffected pathogenicity Gene deletion: full; gene complementation C1_01241 YedF PHI:7643 P0AA34 28901 100.0 77 0 0 1 77 1 77 5.1699999999999996e-54 160.0 0 0 0 0 0 0 0 0 0 0 C1_01247 FliD PHI:6733 P24216 562 99.6 468 2 0 1 468 1 468 5.18e-281 766.0 0 0 0 0 0 0 0 0 0 0 C1_02926 BetI_(VK055_1951) PHI:7521 B5Y006 573 93.3 193 13 0 1 193 1 193 5.19e-126 351.0 0 0 0 0 0 0 0 0 0 0 C1_01276 FlhDC__FlhD PHI:7271__PHI:9419 P0A2R2 28901 89.7 116 9 1 1 116 1 113 5.1e-67 196.0 0 0 0 0 0 0 0 0 0 0 C1_02348 ClpS PHI:8568 E0SMW8 204038 77.4 106 24 0 1 106 1 106 5.23e-56 167.0 0 0 0 0 0 0 0 0 0 0 C1_01101 MagA PHI:2652 Q5KQZ9 573 95.3 193 9 0 1 193 1 193 5.269999999999999e-134 371.0 0 0 0 0 0 0 0 0 0 0 C1_00574 RpoE PHI:2680 P0A2F0 28901 99.5 191 1 0 1 191 1 191 5.28e-133 369.0 0 0 0 0 0 0 0 0 0 0 C1_02331 Lrp PHI:6497__PHI:7128 D3VBH2 628 97.6 164 4 0 1 164 1 164 5.29e-113 316.0 0 0 0 0 0 0 0 0 0 0 C1_03746 YihW PHI:6545 Q9L7R1 28901 71.0 255 74 0 1 255 1 255 5.3000000000000004e-123 349.0 0 0 0 0 0 0 0 0 0 0 C1_01405 Orf408 PHI:612 H9L428 28901 40.0 70 38 1 1 66 1 70 5.32e-09 54.3 0 0 0 0 0 0 0 0 0 0 C1_00426 STM14_RS15230 PHI:10059 A0A0F6B5P9 28901 92.8 321 23 0 1 321 1 321 5.330000000000001e-209 572.0 ACY89843 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) NorR family transcriptional regulator unaffected pathogenicity Gene deletion: full C1_03100 XC_2466 PHI:3968 Q4UTV7 339 51.2 123 60 0 4 126 4 126 5.3499999999999997e-42 133.0 AAY49516 Xanthomonas campestris pv. campestris strain 8004 Black rot Eudicots 3726 Raphanus sativus (related: radish) Aspartate alpha-decarboxylase reduced virulence Gene mutation C1_03611 HupA PHI:3074 D0Z9U0 636 94.4 90 5 0 1 90 1 90 5.34e-53 158.0 0 0 0 0 0 0 0 0 0 0 C1_00088 YqiC PHI:6697 A0A0U1J4N7 28901 84.0 94 14 1 1 94 1 93 5.3699999999999995e-45 139.0 0 0 0 0 0 0 0 0 0 0 C1_01277 FlhC_(Dda3937_02784) PHI:8572 E0SIM9 204038 83.3 192 32 0 1 192 1 192 5.3e-113 318.0 0 0 0 0 0 0 0 0 0 0 C1_03848 PpiC PHI:11419 A0A0F7DJX4 28901 94.6 92 5 0 1 92 1 92 5.4299999999999995e-61 179.0 0 0 0 0 0 0 0 0 0 0 C1_01417 Plc2_(bpsl0337) PHI:10934 Q63Y51 28450 49.0 51 25 1 9 59 13 62 5.42e-07 44.3 0 0 0 0 0 0 0 0 0 0 C1_00710 EutR PHI:11464 D2TT81 67825 92.0 349 28 0 1 349 1 349 5.44e-244 662.0 0 0 0 0 0 0 0 0 0 0 C1_01099 Bcam2256 PHI:8833 B4EGX2 95486 41.5 164 91 2 678 838 249 410 5.45e-27 113.0 0 0 0 0 0 0 0 0 0 0 C1_02649 HilD PHI:635__PHI:7270__PHI:9084__PHI:9231__PHI:9522__PHI:11209 P0CL08 28901 41.7 120 70 0 116 235 186 305 5.46e-23 93.6 0 0 0 0 0 0 0 0 0 0 C1_03115 LpdA PHI:6520 Q5ZVD8 446 62.7 475 175 2 1 474 6 479 5.53e-212 592.0 AAU27584 Legionella pneumophila 130b Legionnaires' disease Rodents 10090 Mus musculus (related: house mouse) Effector (plant avirulence determinant) effector (plant avirulence determinant) Gene deletion: full C1_04006 WaaL__RfaL_(ocw) PHI:3106__PHI:9414 P27243 562 93.6 419 27 0 1 419 1 419 5.53e-265 721.0 0 0 0 0 0 0 0 0 0 0 C1_04316 GzOB009 PHI:1569 I1RCH5 5518 47.3 300 119 8 7 268 59 357 5.5499999999999995e-74 229.0 FGSG_01290 Fusarium graminearum GZ3639 Fusarium ear blight Monocots 4564 Triticum (related: wheat) transcription factor lethal Gene deletion C1_02453 AroG1 PHI:8884 Q8XW15 305 64.2 352 123 1 1 349 1 352 5.55e-165 463.0 0 0 0 0 0 0 0 0 0 0 C1_02410 RhlE1_(PA3950)__RhlE2_(PA0428) PHI:11622__PHI:11623 Q9HX66 287 58.3 379 157 1 1 379 1 378 5.56e-145 420.0 0 0 0 0 0 0 0 0 0 0 C1_00573 NadB PHI:8507 Q83F48 777 53.1 531 225 7 10 531 5 520 5.570000000000001e-184 526.0 0 0 0 0 0 0 0 0 0 0 C1_03150 MoIlv6 PHI:3976 G4NC97 318829 44.7 94 52 0 2 95 81 174 5.5e-18 77.4 EHA48246 Magnaporthe oryzae Guy11 Blast (rice) Monocots 4530 Oryza sativa (related: rice) Acetolactate synthases loss of pathogenicity Gene disruption; gene complementation C1_00550 YfiA PHI:3675__PHI:3681 D4HX89 552 82.1 112 20 0 1 112 1 112 5.5e-61 180.0 0 0 0 0 0 0 0 0 0 0 C1_03454 BlaCMY-2 PHI:6133 Q6PT92 28901 75.8 380 89 1 1 377 2 381 5.63e-217 597.0 0 0 0 0 0 0 0 0 0 0 C1_00409 STM14_RS15290 PHI:10071 A0A0F6B5R4 28901 90.2 307 30 0 1 307 1 307 5.67e-197 540.0 ACY89858 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) Formate hydrogenlyase subunit 3 unaffected pathogenicity Gene deletion: full C1_03674 MetJ PHI:9083 P06203 28901 98.1 105 2 0 1 105 1 105 5.700000000000001e-73 210.0 0 0 0 0 0 0 0 0 0 0 C1_01496 STM14_RS07715_(sufD) PHI:10101 A0A0F6B0W6 28901 79.3 421 87 0 1 421 1 421 5.749999999999999e-246 674.0 0 0 0 0 0 0 0 0 0 0 C1_03003 ImpJ PHI:10596 A0A1M5U2L7 554 46.4 446 231 5 3 443 2 444 5.78e-133 389.0 0 0 0 0 0 0 0 0 0 0 C1_00919 PmrF PHI:2656 D0ZPP5 28901 87.7 318 39 0 1 318 1 318 5.78e-201 551.0 0 0 0 0 0 0 0 0 0 0 C1_02100 PotD PHI:11189 B8F6H2 738 53.4 341 156 1 8 348 12 349 5.79e-128 369.0 0 0 0 0 0 0 0 0 0 0 C1_04373 PccS1_001523 PHI:10577 C6DIJ6 554 98.0 98 2 0 1 98 1 98 5.7e-63 184.0 ACT11296 Pectobacterium carotovorum subsp. carotovorum strain PccS1 Soft rot Monocots 69721 Zantedeschia aethiopica (related: arum-lily) Transcriptional regulator, Fis family, Fis unaffected pathogenicity Gene deletion: full; gene complementation C1_02615 FepG_(VK055_1929) PHI:7542 W9B576 573 82.7 330 57 0 1 330 1 330 5.8100000000000005e-183 506.0 0 0 0 0 0 0 0 0 0 0 C1_01571 RstA PHI:9601 A0A0E1M219 562 99.6 239 1 0 1 239 1 239 5.81e-172 471.0 AJF56459 Escherichia coli serotype O157:H7 Infection Primates 9606 Homo sapiens (related: human) Two-component response regulator reduced virulence Gene deletion: full; gene complementation C1_03147 RsmH PHI:4961 P60392 1280 41.1 314 169 5 5 309 2 308 5.83e-73 226.0 0 0 0 0 0 0 0 0 0 0 C1_00450 MprA PHI:5407__PHI:7646 P0ACR9 562 100.0 176 0 0 1 176 1 176 5.84e-125 347.0 0 0 0 0 0 0 0 0 0 0 C1_04015 Pgm PHI:11412 Q8ZJN0 632 83.5 515 84 1 1 514 1 515 5.85e-313 851.0 0 0 0 0 0 0 0 0 0 0 C1_04323 RplN PHI:11120 Q7VTC1 520 76.4 123 28 1 1 123 1 122 5.85e-63 186.0 0 0 0 0 0 0 0 0 0 0 C1_01232 Filj PHI:6463 P0A1K1 28901 87.8 147 18 0 1 147 1 147 5.85e-86 246.0 0 0 0 0 0 0 0 0 0 0 C1_02548 AatJ_(PSPTO_4171) PHI:10621 Q87XK7 317 56.5 292 126 1 10 300 7 298 5.94e-111 322.0 0 0 0 0 0 0 0 0 0 0 C1_00767 STY3178_(YfdX) PHI:8849 Q8Z3Y9 28901 46.9 162 86 0 46 207 24 185 5.9599999999999995e-46 149.0 0 0 0 0 0 0 0 0 0 0 C1_02637 VgrG-1 PHI:9887 A0A0H3AIG7 666 42.3 522 286 6 5 514 4 522 5.96e-131 410.0 ABQ19866 Vibrio cholerae serogroup O139 Cholera Primates 9606 Homo sapiens (related: human) Actin cross-linking toxin reduced virulence Gene mutation C1_03216 SatP PHI:9230 P0AC98 562 100.0 188 0 0 1 188 1 188 5.97e-133 368.0 0 0 0 0 0 0 0 0 0 0 C1_00979 PXO_RS06090 PHI:9020 A0A0K0GI78 347 43.4 205 110 2 7 206 2 205 5.97e-45 147.0 Xanthomonas oryzae pv. oryzae strain PXO99A Bacterial leaf blight Monocots 4530 Oryza sativa (related: rice) Response regulator reduced virulence Gene mutation; gene complementation C1_04368 OqxB PHI:6449 W9B4Q6 573 41.8 1040 587 11 2 1030 4 1036 5.99e-248 726.0 0 0 0 0 0 0 0 0 0 0 C1_01254 Cab_(NMB0789) PHI:8623 Q9K033 487 55.3 244 104 2 4 244 2 243 6.01e-84 249.0 0 0 0 0 0 0 0 0 0 0 C1_02450 GalK PHI:6269 P0A6T3 562 99.7 382 1 0 1 382 1 382 6.029999999999999e-280 756.0 0 0 0 0 0 0 0 0 0 0 C1_01804 PaaE PHI:3172__PHI:9580 B4E598 95486 46.1 358 184 3 4 353 6 362 6.02e-105 311.0 0 0 0 0 0 0 0 0 0 0 C1_03606 PXO_RS02690 PHI:9014 A0A0K0GGF6 347 45.7 446 222 7 8 439 4 443 6.03e-111 332.0 Xanthomonas oryzae pv. oryzae strain PXO99A Bacterial leaf blight Monocots 4530 Oryza sativa (related: rice) Response regulator unaffected pathogenicity Gene mutation C1_01500 STM14_RS07740_(lpp) PHI:10106 A0A0F6B0X1 28901 96.2 78 3 0 1 78 1 78 6.05e-31 102.0 0 0 0 0 0 0 0 0 0 0 C1_03435 Cpipt-log__Ipt-log_(cpur_04177) PHI:6267__PHI:8120 M1WES1 5111 40.6 106 61 1 12 117 7 110 6.07e-13 67.4 0 0 0 0 0 0 0 0 0 0 C1_03753 NtrC PHI:11700 Q9HU59 287 69.3 463 138 1 6 468 7 465 6.1000000000000006e-226 627.0 0 0 0 0 0 0 0 0 0 0 C1_01920 PspD PHI:7660 A0A0F6B1W8 28901 87.5 72 9 0 1 72 1 72 6.149999999999999e-42 129.0 0 0 0 0 0 0 0 0 0 0 C1_04300 FkpA PHI:4583 C9Y236 413502 83.9 273 40 2 1 269 1 273 6.14e-147 410.0 CBA34185 Cronobacter turicensis LMG 23827 Meningitis; bacteremia Primates 9606 Homo sapiens (related: human) virulence factor reduced virulence Gene mutation; gene complementation C1_03708 SodA PHI:11376 P43019 28901 98.1 206 4 0 1 206 1 206 6.14e-153 420.0 0 0 0 0 0 0 0 0 0 0 C1_04514 RegA PHI:5244 D2TIS0 67825 40.2 97 58 0 137 233 172 268 6.17e-18 79.3 CBG90830 Citrobacter rodentium ICC180 Rodents 10090 Mus musculus (related: house mouse) Transcriptional regulator of virulence reduced virulence Gene mutation; gene complementation C1_00399 STM14_RS15340 PHI:10081 A0A0F6B5S6 28901 86.8 114 15 0 1 114 1 114 6.19e-73 211.0 ACY89870 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) Iron ABC transporter substrate-binding protein unaffected pathogenicity Gene deletion: full C1_02784 GzWing006 PHI:1634 I1RDI9 5518 41.6 113 53 4 2 101 5 117 6.1e-18 71.6 FGSG_01689 Fusarium graminearum GZ3639 Fusarium ear blight Monocots 4564 Triticum (related: wheat) transcription factor unaffected pathogenicity Gene deletion C1_02800 ClpX PHI:9833 Q8PBY5 339 76.2 416 95 2 1 413 1 415 6.240000000000001e-226 623.0 0 0 0 0 0 0 0 0 0 0 C1_04259 DamX PHI:6729 P11557 562 97.0 428 13 0 1 428 1 428 6.2499999999999994e-220 608.0 0 0 0 0 0 0 0 0 0 0 C1_00157 Rv1837c_(glcB) PHI:7586 P9WK17 1773 57.6 724 293 4 1 716 1 718 6.249999999999999e-297 828.0 0 0 0 0 0 0 0 0 0 0 C1_04258 AroB PHI:4250 C5A9K4 337 58.3 345 143 1 1 345 1 344 6.28e-131 377.0 0 0 0 0 0 0 0 0 0 0 C1_00712 AmiA PHI:10979 P36548 562 99.7 289 1 0 1 289 1 289 6.29e-201 548.0 0 0 0 0 0 0 0 0 0 0 C1_01737 NarV PHI:10519 P0AF32 562 99.6 226 1 0 1 226 1 226 6.31e-165 452.0 0 0 0 0 0 0 0 0 0 0 C1_04025 Apa1 PHI:4673__PHI:5230 A3MZG1 715 42.0 138 69 1 1479 1616 3221 3347 6.31e-19 92.4 0 0 0 0 0 0 0 0 0 0 C1_03541 OxyR PHI:3091 H3RJ93 66269 69.7 145 44 0 9 153 9 153 6.33e-72 211.0 EHT98350 Pantoea stewartii subsp. stewartii strain DC283 Stewart's wilt Monocots 4577 Zea mays (related: maize) activate gene expression in response to oxidative stress unaffected pathogenicity Gene mutation C1_03315 mD PHI:10210 A0A2X3EJX6 573 40.2 694 370 12 40 727 36 690 6.340000000000001e-163 493.0 0 0 0 0 0 0 0 0 0 0 C1_04198 GGT PHI:7689 D6XQY8 210 52.5 537 248 5 41 571 29 564 6.359999999999999e-191 546.0 0 0 0 0 0 0 0 0 0 0 C1_01311 ZnuA PHI:11005 P39172 562 100.0 310 0 0 19 328 1 310 6.35e-223 607.0 0 0 0 0 0 0 0 0 0 0 C1_00423 NorW PHI:10669 P37596 562 99.2 377 3 0 1 377 1 377 6.38e-268 725.0 0 0 0 0 0 0 0 0 0 0 C1_01802 PaaB PHI:9577 A0A088U4K2 95486 52.8 250 116 2 13 262 16 263 6.38e-87 258.0 0 0 0 0 0 0 0 0 0 0 C1_00640 Gua1 PHI:6871 J9VUY6 5207 49.7 547 245 8 2 524 3 543 6.420000000000001e-181 518.0 0 0 0 0 0 0 0 0 0 0 C1_00247 UbiI PHI:7028 P25535 562 98.8 400 5 0 1 400 1 400 6.42e-291 785.0 0 0 0 0 0 0 0 0 0 0 C1_00279 ArcC PHI:3475 Q97NA2 1313 49.7 312 150 5 2 308 3 312 6.46e-94 279.0 0 0 0 0 0 0 0 0 0 0 C1_00595 BCFHG1 PHI:2304 B0JFC8 40559 41.8 409 215 5 2 391 3 407 6.570000000000001e-103 309.0 CAP74387 Botrytis cinerea B05.10 Grey mold Eudicots 4081 Solanum lycopersicum (related: tomato) NO detoxification unaffected pathogenicity Gene deletion: full C1_00896 NuoI_(PA2644) PHI:8937 Q9I0J4 287 86.0 172 24 0 9 180 11 182 6.610000000000001e-97 276.0 0 0 0 0 0 0 0 0 0 0 C1_00435 RecA PHI:10380 A3M645 470 74.1 328 85 0 3 330 1 328 6.61e-174 485.0 ABO12389 Acinetobacter baumannii ATCC 17978 Nosocomial infection Nematodes 6239 Caenorhabditis elegans (related: roundworm) DNA strand exchange and recombination protein reduced virulence Gene deletion: full; gene complementation C1_01223 RcsA PHI:3013 P54698 28901 87.9 207 25 0 1 207 1 207 6.659999999999999e-128 357.0 0 0 0 0 0 0 0 0 0 0 C1_03209 NhaR PHI:3267 P0A9G2 562 99.7 299 1 0 1 299 3 301 6.69e-222 602.0 0 0 0 0 0 0 0 0 0 0 C1_02571 PA4485 PHI:5448 Q9HVT6 287 44.3 97 52 1 75 169 28 124 6.74e-18 77.4 AAG07873 Pseudomonas aeruginosa PAO1 Nosocomial infection Rodents 10090 Mus musculus (related: house mouse) Cell envelope protein unaffected pathogenicity Gene mutation C1_01891 FNR__Fnr PHI:4876__PHI:7248 P0A9E5 562 100.0 250 0 0 1 250 1 250 6.79e-181 494.0 0 0 0 0 0 0 0 0 0 0 C1_02014 NarI PHI:10515 P11350 562 99.6 225 1 0 1 225 1 225 6.8200000000000006e-164 449.0 0 0 0 0 0 0 0 0 0 0 C1_00625 SseB PHI:3761 D0ZRW0 28901 90.7 258 24 0 1 258 4 261 6.859999999999999e-172 473.0 0 0 0 0 0 0 0 0 0 0 C1_02197 PgaC PHI:3448 B5Y383 573 66.2 438 147 1 1 437 1 438 6.860000000000001e-212 589.0 0 0 0 0 0 0 0 0 0 0 C1_02482 VdOGDH_(VDAG_10018) PHI:9378 G2XIN6 27337 40.1 979 522 13 11 932 68 1039 6.86e-229 674.0 0 0 0 0 0 0 0 0 0 0 C1_02332 Trr1 PHI:6470 J5K974 176275 47.7 323 151 6 6 317 2 317 6.899999999999999e-90 270.0 EJP70691 Beauveria bassiana ARSEF 2860 White muscardine Moths 7137 Galleria mellonella (related: greater wax moth) Thioredoxin reductase unaffected pathogenicity Gene mutation; gene complementation C1_00956 OmpC PHI:9892 A0A2S4MYF8 623 95.2 375 16 1 1 375 1 373 6.89e-266 720.0 AAN43817 Shigella flexneri serotype 2a strain 301 Shigellosis Primates 9606 Homo sapiens (related: human) Outer membrane protein C reduced virulence Gene disruption C1_03937 IbpA PHI:4102 Q8FXL4 29461 57.6 139 56 2 1 136 1 139 6.89e-47 147.0 0 0 0 0 0 0 0 0 0 0 C1_00657 FleQ PHI:3219 Q5GZM8 347 47.1 348 146 6 351 664 142 485 6.91e-84 271.0 0 0 0 0 0 0 0 0 0 0 C1_00427 STM14_RS15225 PHI:10058 A0A0F6B5P8 28901 94.9 257 13 0 1 257 1 257 6.930000000000001e-173 475.0 ACY89842 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) Arabinose 5-phosphate isomerase unaffected pathogenicity Gene deletion: full C1_03386 TamA PHI:10714 D4F0Q0 636 66.3 572 189 2 10 577 7 578 6.93e-283 780.0 0 0 0 0 0 0 0 0 0 0 C1_00614 SuhB PHI:3915 Q02RX2 287 55.0 271 118 2 1 267 1 271 6.94e-97 283.0 ABJ13079 Pseudomonas aeruginosa PAK Nosocomial infection Rodents 10090 Mus musculus (related: house mouse) an essential gene for the T3SS gene expression loss of pathogenicity Gene mutation C1_02612 FepB_(VK055_1926) PHI:7478 A0A060VFL5 573 84.7 307 46 1 13 318 12 318 6.96e-183 505.0 0 0 0 0 0 0 0 0 0 0 C1_03879 GidA PHI:11091 A4VYE0 1307 49.6 619 311 1 3 620 5 623 6.9e-203 581.0 0 0 0 0 0 0 0 0 0 0 C1_02248 HyaA PHI:11000 P69739 562 99.7 372 1 0 1 372 1 372 7.06e-283 763.0 0 0 0 0 0 0 0 0 0 0 C1_03843 Thioredoxin_1 PHI:2644 P0AA28 28901 100.0 109 0 0 1 109 1 109 7.06e-78 223.0 0 0 0 0 0 0 0 0 0 0 C1_03605 XC_0509 PHI:3942 Q4UZD3 339 69.7 429 129 1 1 429 1 428 7.08e-206 573.0 AAY47590 Xanthomonas campestris pv. campestris strain 8004 Black rot Eudicots 3726 Raphanus sativus (related: radish) Phosphoribosylamine-glycine ligase reduced virulence Gene mutation C1_00438 CsrA PHI:10254 P69913 562 100.0 61 0 0 1 61 1 61 7.09e-36 113.0 0 0 0 0 0 0 0 0 0 0 C1_03997 RfaG PHI:9593 H9L435 28901 89.6 374 39 0 1 374 1 374 7.21e-252 684.0 0 0 0 0 0 0 0 0 0 0 C1_02625 YbdK_(VK055_1976) PHI:7496 A0A086IIR8 573 69.5 370 113 0 1 370 1 370 7.240000000000001e-200 553.0 0 0 0 0 0 0 0 0 0 0 C1_02007 GalU PHI:3112 Q8P8Q1 339 46.6 290 146 5 4 291 1 283 7.269999999999999e-76 232.0 0 0 0 0 0 0 0 0 0 0 C1_02428 UvrB PHI:11576 Q8DYL6 1311 56.2 662 279 3 5 666 10 660 7.27e-256 719.0 0 0 0 0 0 0 0 0 0 0 C1_03597 AoMls PHI:4021 G1XLT2 2813651 49.9 509 243 8 22 525 22 523 7.28e-163 472.0 EGX45923 Orbilia oligospora CBS 115.81 Nematode trapping fungus Nematodes 6239 Caenorhabditis elegans (related: roundworm) Malate synthase reduced virulence Gene deletion: full C1_02773 RsmS_(ECA1172) PHI:8933 Q6D803 29471 66.7 48 16 0 1 48 1 48 7.32e-15 59.7 0 0 0 0 0 0 0 0 0 0 C1_04310 Bfr_(atu2771) PHI:10827 Q7CWA3 358 49.0 151 77 0 1 151 9 159 7.32e-45 143.0 0 0 0 0 0 0 0 0 0 0 C1_03151 ILV2 PHI:358 Q6SSJ3 5207 41.8 595 305 14 4 568 126 709 7.37e-136 410.0 AAR29084 Cryptococcus neoformans H99 Cryptococcosis Rodents 10090 Mus musculus (related: house mouse) Acetolactate synthase loss of pathogenicity Gene disruption; gene complementation C1_03143 MurF PHI:7632 Q9HVZ7 287 47.2 449 224 8 6 446 7 450 7.43e-112 335.0 0 0 0 0 0 0 0 0 0 0 C1_01720 XC_1368 PHI:3951 Q4UWY6 339 51.7 145 67 3 1 143 1 144 7.510000000000001e-43 137.0 AAY48437 Xanthomonas campestris pv. campestris strain 8004 Black rot Eudicots 3726 Raphanus sativus (related: radish) Osmotically inducible protein, oxidative stress resistance reduced virulence Gene mutation C1_00968 NapH PHI:10524 P33934 562 100.0 287 0 0 1 287 1 287 7.520000000000001e-217 588.0 0 0 0 0 0 0 0 0 0 0 C1_02719 ADE2 PHI:14 P0C017 5207 51.0 155 74 1 10 164 414 566 7.579999999999999e-42 145.0 AAB09711 Cryptococcus neoformans var. grubii serotype A strain H99 Cryptococcosis Rabbits & hares 9986 Oryctolagus cuniculus (related: rabbit) Phosphoribosylaminoimidazole carboxylase loss of pathogenicity Gene disruption; gene complementation C1_02306 YbtQ PHI:6913 A0A0E0V727 562 48.1 239 123 1 341 579 343 580 7.62e-63 216.0 0 0 0 0 0 0 0 0 0 0 C1_00961 Mqo PHI:6190 Q5HDJ0 1280 51.1 472 228 2 27 498 3 471 7.63e-165 476.0 AGY90568 Staphylococcus aureus Newman Skin infection; food poisoning; respiratory disease Rodents 10090 Mus musculus (related: house mouse) malate-quinone oxidoreductases reduced virulence Gene mutation C1_00206 SpeB PHI:9150 P60651 562 100.0 306 0 0 1 306 1 306 7.63e-231 625.0 0 0 0 0 0 0 0 0 0 0 C1_04433 RpoN PHI:2906__PHI:3673__PHI:3679 D4HUY5 552 76.3 477 113 0 1 477 1 477 7.690000000000001e-248 683.0 0 0 0 0 0 0 0 0 0 0 C1_03051 PA3644 PHI:3785 Q9X6P4 287 52.7 203 96 0 60 262 56 258 7.72e-69 211.0 AF142597_1 Pseudomonas aeruginosa PAO1 Infection Beetles 7067 Tenebrio molitor (related: yellow mealworm) acyltransferases reduced virulence Altered gene expression / gene regulation: overexpression C1_02129 Acp1_(PA1869) PHI:8556 O52658 287 49.3 73 37 0 1 73 1 73 7.75e-18 68.9 0 0 0 0 0 0 0 0 0 0 C1_03478 Krs_(BBA_03037) PHI:9409 J5K1T7 176275 40.5 499 273 7 29 504 95 592 7.769999999999999e-113 344.0 0 0 0 0 0 0 0 0 0 0 C1_03313 mG PHI:10212 B0LF87 573 74.3 167 42 1 1 167 1 166 7.86e-82 237.0 0 0 0 0 0 0 0 0 0 0 C1_01344 KdgR PHI:4175 U6ZHA8 1089444 89.4 263 28 0 1 263 1 263 7.91e-166 457.0 0 0 0 0 0 0 0 0 0 0 C1_00592 QseG PHI:9122 P0AD45 562 98.3 237 4 0 1 237 1 237 7.92e-169 463.0 0 0 0 0 0 0 0 0 0 0 C1_00544 YfiN PHI:7571 W9B3Z6 573 62.2 407 154 0 2 408 1 407 7.959999999999999e-170 479.0 0 0 0 0 0 0 0 0 0 0 C1_00468 LruA PHI:4150 Q3BDH0 173 48.7 39 20 0 109 147 423 461 7.95e-06 42.7 AAW65729 Leptospira interrogans serovar Manilae strain L495 Leptospirosis Rodents 10036 Mesocricetus auratus (related: golden hamster) lipoprotein that has been implicated in leptospiral uveitis as a target of the immune response reduced virulence Gene mutation C1_01786 GAPDH PHI:6904 P0A038 1280 58.7 334 132 5 3 333 4 334 7.98e-131 375.0 CAB38645 Staphylococcus aureus USA300 JE2 White muscardine Moths 7137 Galleria mellonella (related: greater wax moth) Glyceraldehyde-3-phosphate dehydrogenase reduced virulence Functional test in host: direct injection C1_00202 MGG_00383 PHI:877 G4NCL5 318829 54.3 372 164 4 5 370 17 388 7.98e-136 392.0 MGG_00383 Magnaporthe oryzae KJ201 Blast (rice) Monocots 4530 Oryza sativa (related: rice) Hypothetical protein reduced virulence Gene disruption C1_01139 HisF_(A1S_3245) PHI:10701 A3M9P1 470 42.0 257 144 2 1 257 1 252 7.9e-69 211.0 0 0 0 0 0 0 0 0 0 0 C1_01466 Gpx31 PHI:4936 Q59WW7 5476 47.8 159 64 2 11 169 10 149 8.02e-44 141.0 0 0 0 0 0 0 0 0 0 0 C1_03364 MgtB PHI:7573 Q669S4 633 52.0 870 393 5 50 896 29 896 8.06e-313 882.0 CAH21648 Yersinia pseudotuberculosis IP32953 Zoonotic infection Moths 7137 Galleria mellonella (related: greater wax moth) Magnesium ion transporter reduced virulence Gene deletion: full; gene complementation C1_00421 STM14_RS15255 PHI:10064 A0A0F6B5Q6 28901 96.0 173 7 0 1 173 1 173 8.13e-126 349.0 ACY89850 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) Hypothetical protein unaffected pathogenicity Gene deletion: full C1_03434 Hfq PHI:2687 P0A1R0 28901 91.2 102 9 0 1 102 1 102 8.16e-49 149.0 0 0 0 0 0 0 0 0 0 0 C1_00384 RpoS PHI:7256 P13445 562 99.7 330 1 0 1 330 1 330 8.18e-229 622.0 BAA02747 Escherichia coli E2348/69 Diarrhea Primates 9606 Homo sapiens (related: human) RNA polymerase sigma factor unaffected pathogenicity Gene mutation C1_01004 FruA1 PHI:6524 O51369 139 46.7 465 221 11 104 552 164 617 8.250000000000001e-79 258.0 0 0 0 0 0 0 0 0 0 0 C1_04102 BcsE PHI:11602 Q8ZLB5 28901 80.0 519 104 0 1 519 5 523 8.27e-314 853.0 0 0 0 0 0 0 0 0 0 0 C1_02616 FepC_(VK055_1930) PHI:7541 W9B5Y9 573 88.6 263 30 0 1 263 1 263 8.31e-168 463.0 0 0 0 0 0 0 0 0 0 0 C1_03111 SpeD PHI:9152 P0A7F6 562 100.0 264 0 0 1 264 1 264 8.34e-198 538.0 0 0 0 0 0 0 0 0 0 0 C1_03911 EaAdeP_(EAMY_3685) PHI:10919 D4I4J9 552 83.4 433 72 0 13 445 5 437 8.390000000000001e-248 680.0 0 0 0 0 0 0 0 0 0 0 C1_03312 FimH PHI:2690__PHI:7180__PHI:7204__PHI:7846__PHI:8107__PHI:9788__PHI:11259 P08191 562 99.7 300 1 0 1 300 1 300 8.419999999999999e-216 587.0 0 0 0 0 0 0 0 0 0 0 C1_02717 PpiB PHI:11418 A0A0F7DI09 28901 98.2 164 3 0 1 164 1 164 8.48e-119 330.0 0 0 0 0 0 0 0 0 0 0 C1_03039 NlpE PHI:8514 D2TI83 67825 79.7 231 47 0 3 233 2 232 8.49e-140 389.0 0 0 0 0 0 0 0 0 0 0 C1_03791 PccS1_001441 PHI:10576 C6DI95 554 84.8 310 47 0 1 310 1 310 8.4e-198 543.0 ACT15089 Pectobacterium carotovorum subsp. carotovorum strain PccS1 Soft rot Monocots 69721 Zantedeschia aethiopica (related: arum-lily) Transcriptional regulator, LysR family, MetR unaffected pathogenicity Gene deletion: full; gene complementation C1_01118 RfbB PHI:703 Q06951 666 67.1 462 144 3 1 456 1 460 8.54e-229 633.0 AAF93418 Vibrio cholerae O395 Cholera Rodents 10090 Mus musculus (related: house mouse) O-antigen biosynthesis reduced virulence Gene disruption C1_01203 AdcA PHI:9798 Q9A0L9 1314 47.3 188 96 2 39 223 328 515 8.55e-53 176.0 0 0 0 0 0 0 0 0 0 0 C1_00080 RfaE PHI:3147 B8F4X8 738 70.4 467 138 0 6 472 7 473 8.570000000000001e-235 650.0 0 0 0 0 0 0 0 0 0 0 C1_02647 STM14_RS15375 PHI:10088 A0A0F6B5T5 28901 40.2 102 61 0 143 244 189 290 8.57e-20 84.7 ACY89879 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) Transcriptional regulator unaffected pathogenicity Gene deletion: full C1_02927 VK055_1952 PHI:7520 A0A076ZMY5 573 89.3 487 52 0 4 490 1 487 8.64e-318 861.0 AIK80558 Klebsiella pneumoniae KPPR1 Pneumonia Rodents 10090 Mus musculus (related: house mouse) Betaine aldehyde dehydrogenase unaffected pathogenicity Gene deletion: full C1_02202 EfeO PHI:10991 P0AB24 562 99.5 375 2 0 1 375 1 375 8.67e-265 717.0 0 0 0 0 0 0 0 0 0 0 C1_03141 MurD PHI:7631 Q9HVZ9 287 50.3 443 199 8 10 437 11 447 8.6e-124 365.0 0 0 0 0 0 0 0 0 0 0 C1_02838 TreY PHI:2745 Q02LV5 287 42.5 80 44 1 177 254 15 94 8.74e-10 60.1 0 0 0 0 0 0 0 0 0 0 C1_02563 LptE PHI:10313 P0ADC1 562 100.0 193 0 0 1 193 1 193 8.74e-133 368.0 BAA35288 Escherichia coli KP7600 Urinary tract infection Rodents 10090 Mus musculus (related: house mouse) LPS-assembly protein unaffected pathogenicity Gene mutation C1_01554 ExpI PHI:4179 U6ZHS1 1089444 74.3 70 18 0 1 70 1 70 8.81e-39 121.0 0 0 0 0 0 0 0 0 0 0 C1_01250 FliZ PHI:9178 P0A210 28901 79.2 183 38 0 1 183 1 183 8.820000000000001e-103 291.0 BAA36398 Salmonella enterica subsp. enterica serovar Typhimurium strain ATCC 14028 Salmonellosis Rodents 10090 Mus musculus (related: house mouse) Flagellar protein reduced virulence Gene mutation C1_00425 STM14_RS15235 PHI:10060 A0A0F6B5Q0 28901 88.8 507 53 2 1 504 1 506 8.83e-317 860.0 ACY89844 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) Anaerobic nitric oxide reductase flavorubredoxin unaffected pathogenicity Gene deletion: full C1_01106 Ams PHI:2471 Q46631 552 53.0 713 330 2 1 710 1 711 8.85e-255 720.0 X77921 Erwinia amylovora Ea1189 Fire blight Eudicots 3750 Malus domestica (related: apple) Exopolysaccharides Amylovoran loss of pathogenicity Gene deletion: full C1_00867 Bab2_0612 PHI:7201 Q2YKP4 235 40.0 240 126 4 26 258 25 253 8.899999999999999e-55 175.0 0 0 0 0 0 0 0 0 0 0 C1_01282 CheM PHI:6983 P02941 28901 78.3 554 118 2 1 553 1 553 8.8e-233 651.0 0 0 0 0 0 0 0 0 0 0 C1_03536 YjcH PHI:9228 P0AF54 562 100.0 104 0 0 1 104 1 104 8.8e-72 207.0 0 0 0 0 0 0 0 0 0 0 C1_00962 Eco PHI:4101 Q63W37 28450 44.4 142 77 2 20 160 37 177 8.91e-39 128.0 CAH35049 Burkholderia pseudomallei K96423 Melioidosis Rodents 10090 Mus musculus (related: house mouse) serine protease inhibitor reduced virulence Gene mutation C1_03700 PfkA PHI:9309 D4HUC7 552 87.8 320 39 0 1 320 1 320 8.92e-212 578.0 0 0 0 0 0 0 0 0 0 0 C1_00412 STM14_RS15275 PHI:10068 A0A0F6B5R1 28901 96.5 255 9 0 1 255 1 255 8.930000000000001e-184 502.0 ACY89855 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) Formate hydrogenlyase complex iron-sulfur subunit unaffected pathogenicity Gene deletion: full C1_03555 PspG PHI:7661 A0A0F6BA89 28901 90.0 60 6 0 1 60 1 60 9.030000000000001e-27 91.7 0 0 0 0 0 0 0 0 0 0 C1_02214 PA2146 PHI:10946 Q9I1W9 287 80.0 30 6 0 1 30 1 30 9.04e-10 47.0 AE004642_1 Pseudomonas aeruginosa PAO1 Nosocomial infection Primates 9606 Homo sapiens (related: human) Conserved hypothetical protein increased virulence (hypervirulence) Gene deletion: full; gene complementation C1_01287 CheZ__Chez PHI:10050 P07800 28901 93.0 214 15 0 1 214 1 214 9.069999999999999e-134 372.0 0 0 0 0 0 0 0 0 0 0 C1_02648 IcsP PHI:6577 O33641 623 57.7 317 132 1 1 317 1 315 9.13e-133 378.0 AAC45084 Shigella flexneri M90T Shigellosis Rodents 10090 Mus musculus (related: house mouse) Outer membrane protease reduced virulence Gene deletion: full; gene complementation C1_00160 VcpD PHI:702 O68839 666 46.1 267 133 4 4 259 2 268 9.17e-72 220.0 AAC63504 Vibrio cholerae O395 Cholera Rodents 10090 Mus musculus (related: house mouse) Required for philus assembly and CT secretion reduced virulence Gene disruption C1_02263 OmpA PHI:9891 A0A2S4N3N0 623 98.0 350 5 1 1 350 1 348 9.26e-256 692.0 AAN42586 Shigella flexneri serotype 2a strain 301 Shigellosis Primates 9606 Homo sapiens (related: human) Outer membrane protein A reduced virulence Gene disruption C1_02294 YcbK PHI:11001 P0AB06 562 100.0 182 0 0 1 182 1 182 9.27e-134 370.0 0 0 0 0 0 0 0 0 0 0 C1_02116 NagZ PHI:3282 Q4USG7 339 45.2 279 150 2 4 280 2 279 9.33e-76 234.0 AAY50006 Xanthomonas campestris pv. campestris strain Xc17 Black rot Eudicots 3712 Brassica oleracea (no common name found) b-lactamase induction reduced virulence Gene disruption; gene complementation C1_03318 FimA PHI:9888 Q0SXL9 562 95.1 182 9 0 1 182 1 182 9.34e-109 306.0 0 0 0 0 0 0 0 0 0 0 C1_01044 Orf242 PHI:602 H9L471 28901 44.3 228 127 0 4 231 3 230 9.39e-64 197.0 0 0 0 0 0 0 0 0 0 0 C1_04603 StbA PHI:3113 F4MD99 562 65.6 326 107 2 1 321 1 326 9.3e-145 409.0 0 0 0 0 0 0 0 0 0 0 C1_01087 PXO_RS06785 PHI:9026 A0A0K0GIX3 347 41.0 227 127 3 12 233 5 229 9.42e-46 150.0 Xanthomonas oryzae pv. oryzae strain PXO99A Bacterial leaf blight Monocots 4530 Oryza sativa (related: rice) Response regulator unaffected pathogenicity Gene mutation C1_01279 MotB PHI:6534 P0AF06 562 100.0 308 0 0 1 308 1 308 9.44e-217 590.0 0 0 0 0 0 0 0 0 0 0 C1_01956 CysB PHI:8764 G3XCU6 287 63.7 322 117 0 1 322 1 322 9.47e-151 424.0 0 0 0 0 0 0 0 0 0 0 C1_04438 KdsD PHI:7067 Q5NGP7 263 54.3 311 137 3 18 324 14 323 9.480000000000001e-109 318.0 YP_169795 Francisella tularensis SCHU S4 Tularemia Rodents 10090 Mus musculus (related: house mouse) D-arabinose 5-phosphate isomerase reduced virulence Gene disruption; gene complementation C1_03552 Alr-2 PHI:11459 A0KL98 644 56.8 359 154 1 1 359 1 358 9.51e-142 405.0 0 0 0 0 0 0 0 0 0 0 C1_00411 STM14_RS15280 PHI:10069 A0A0F6B5R2 28901 97.2 178 5 0 1 178 1 178 9.53e-117 327.0 ACY89856 Salmonella enterica subsp. enterica serovar Typhimurium strain 14028s Infection Eudicots 4236 Lactuca sativa (related: garden lettuce) Formate hydrogenlyase subunit 5 unaffected pathogenicity Gene deletion: full C1_02841 PhoR PHI:9434 Q8ZRE1 28901 91.2 431 38 0 1 431 1 431 9.58e-295 798.0 0 0 0 0 0 0 0 0 0 0 C1_00920 ArnB PHI:7949 A6TFA0 573 79.4 379 78 0 7 385 1 379 9.63e-222 609.0 0 0 0 0 0 0 0 0 0 0 C1_00639 GuaB PHI:9306 D4HYB2 552 93.2 488 33 0 1 488 1 488 9.66e-317 858.0 0 0 0 0 0 0 0 0 0 0 C1_01140 HisA PHI:9324 D4HW76 552 75.4 244 60 0 1 244 1 244 9.799999999999999e-135 377.0 0 0 0 0 0 0 0 0 0 0 C1_01690 LsrR PHI:9991 P76141 562 98.7 317 4 0 1 317 1 317 9.82e-203 555.0 0 0 0 0 0 0 0 0 0 0 C1_02122 GlcA PHI:6308 A8Z0F5 1280 49.8 500 225 8 1 474 1 500 9.84e-144 426.0 0 0 0 0 0 0 0 0 0 0 C1_02291 OmpF PHI:7023 P02931 562 100.0 362 0 0 1 362 1 362 9.8e-269 726.0 0 0 0 0 0 0 0 0 0 0