ORF_ID Contig Start Stop Orientation Cut_Off Pass_Bitscore Best_Hit_Bitscore Best_Hit_ARO Best_Identities ARO Model_type SNPs_in_Best_Hit_ARO Other_SNPs Drug Class Resistance Mechanism AMR Gene Family Predicted_DNA Predicted_Protein CARD_Protein_Sequence Percentage Length of Reference Sequence ID Model_ID Nudged Note Z1_00030 HTH-type transcriptional regulator DmlR Loose 650 131.3 adeL 31.16 3000620 protein homolog model n/a n/a fluoroquinolone antibiotic; tetracycline antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MDKIKASEVFVTIVKQGSMIKAADYLGMSRAMVTRYLNEMEEWAGVRLLHRTTRKQSLTSVGELVYQQSLQLLEMAERIPANIPKESHQISGLVRITTAQSLANCALSVAITEFIQLYPLIAVDLQISNQTVNLIEERIDIALRITNHLEPNLIARPLAKCLSVVCAHKDYLAKHGIPNTPDDLTYHQCLTYRFFGSSLWEFSLGDERYSVPVGGNLSANESVVLLQATLQGAGVSLQPYCSAKPYLERGELEILLADYQPQPMGIYAVLASRQNMPAAVRVLLDFLVDWFASSPHWLSLSGERVS MRVFNKVVETNSFSLAADSLGLPRASVTTTIQALEKHLQVRLLNRTTRKISLTPDGAVYYDRTARILADVADIESSFHDAERGPRGQLRIDVPVSIGRLILIPRLRDFHARYPDIDLVIGLNDRPVDLVGEAVDCAIRVGELKDSSLIARRIGTFQCATAASPIYLEKYGEPTSIEDLQKNHKAIHFFSSRTGRNFDWDFVVDDLIKSVSVRGRVSVNDGDAYIDLALQGFGIIQGPRYMLTNHLESGLLKEVLPQWTPAPMPISAVYLQNRHLSLKVKVFVDWVAELFAGCPLLGGTALPFDQKCEFACDKETGHEYTIRTLVEQHNIAEAYTLKT 90.80 gnl|BL_ORD_ID|2323|hsp_num:0 2654 Z1_00060 Leukotoxin export ATP-binding protein LtxB Loose 1000 152.5 msbA 26.2 3003950 protein homolog model n/a n/a nitroimidazole antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MKLIIEGLSLTTQLLGTHLSVATLTAHTIRTTKMGIDFSSLVEYLKSEGFENTLSQRLLDDIPSLAMPVLLLLKNEESAVLTEVSFDETGQRKYKIQQVDGLSIWLTQSELSEKYLGYCWFIKPRITEDVRSELPEYTMPKAWFFKVIWRFKKYYYQIILATFVINFLALVSSLYVMNVYDRVIPNKSYQTLWVLSIGVIIAILFEFTAKMLRGRLTDIAGKKADLIISSALFRKVTNLKLQEKPISSGSYVNNLRDFESVRDFMTSASLLTLVDMPFLILFVSVIALVGGYLAFVPLTIIPLVIIVGLLAQIPLSKYINESMKESSQRQGLAVEAIEGIETLKTNNAMNWAQKRWDYYTAKTASSSMKVKNISNFVIYFAVMMQQLNTIFLVIIGTYLIHSDDPASKITMGALIATVILSGRALSPLGQIAGLAVRFQQAWVALKGVNGIVERPSERESARKYITLKQINGNIKFQNVSFAYNQDSSSVVKNLSFEIKSGEKVGILGRIGSGKSTTLKLAAGLYPAEQGSITLDDVDIRQIDPHYLRNQVLLLEQEPRLFLGSLRENLDLARMDGFSSDQDLIVALKRFGLDKVIKKHPRGLDMSLGENGLGLSGGQKQIVALARMTLRNPKIVLLDEPTTGLDQYSEIQALNAISAWCRSKTLLVVTHRPQVLSIVNRIIVVDNGKVVMDGPRDAVLQQLAKNETEKQITAHSKNQNR MHNDKDLSTWQTFRRLWPTIAPFKAGLIVAGVALILNAASDTFMLSLLKPLLDDGFGKTDRSVLVWMPLVVIGLMILRGITSYVSSYCISWVSGKVVMTMRRRLFGHMMGMPVSFFDKQSTGTLLSRITYDSEQVASSSSGALITVVREGASIIGLFIMMFYYSWQLSIILIVLAPIVSIAIRVVSKRFRNISKNMQNTMGQVTTSAEQMLKGHKEVLIFGGQEVETKRFDKVSNRMRLQGMKMVSASSISDPIIQLIASLALAFVLYAASFPSVMDSLTAGTITVVFSSMIALMRPLKSLTNVNAQFQRGMAACQTLFTILDSEQEKDEGKRVIERATGDVEFRNVTFTYPGRDVPALRNINLKIPAGKTVALVGRSGSGKSTIASLITRFYDIDEGEILMDGHDLREYTLASLRNQVALVSQNVHLFNDTVANNIAYARTEQYSREQIEEAARMAYAMDFINKMDNGLDTVIGENGVLLSGGQRQRIAIARALLRDSPILILDEATSALDTESERAIQAALDELQKNRTSLVIAHRLSTIEKADEIVVVEDGVIVERGTHNDLLEHRGVYAQLHKMQFGQ 123.71 gnl|BL_ORD_ID|2193|hsp_num:0 2423 Z1_00063 Virulence regulon transcriptional activator VirF Loose 470 63.9 gadW 27.2 3003838 protein homolog model n/a n/a macrolide antibiotic; fluoroquinolone antibiotic; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MNAYIDNTLKFKNIIFSNHILLLIRKDCEISITKDNVKYQIDNDSIVFIKKNSALDIILGKNKMPEFIFLSHEVMMEVLKITINNKKEEVTQDNNKDSFIKQANHEDILFFNRLKNKFNDEVITNNKTSLSQILKIAYLLLNFDIPNLILKSKPELTSVKVKDIIISDLQHSWSLKEISSKLFISESSLRKKLEAEKTNFMTLLTTVRMAHAMNLLATTNLTIGQISSLSGYKNTSYFIKKFKKYYKSSPKKLKCLNYRDKII MAHVCSVILVRRSFDIHHEQQKISLHNESILLLDKNLADDFAFCSLDTRRLDIEELTVCHYLQNIRQLPRNLGLHSKDRLLINQSPPIQLVTAIFDSFNDPRVNSPILSKMLYLSCLSMFSHKKELIPLLFNSISTVSGKVERLISFDIAKRWYLRDIAERMYTSESLIKKKLQDENTCFSKILLASRMSMARRLLELRQIPLHTIAEKCGYSSTSYFINTFRQYYGVTPHQFSQHSPGTFS 108.68 gnl|BL_ORD_ID|2087|hsp_num:0 2324 Z1_00064 HTH-type transcriptional activator RhaR Loose 200 83.6 Escherichia coli soxS with mutation conferring antibiotic resistance 42.16 3003511 protein overexpression model n/a n/a fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics antibiotic target alteration; antibiotic efflux; reduced permeability to antibiotic ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams MHDKIINDILDWIEDNLTKPISTIDVIKKSGYSQRYFQDLFLHKTKSTIAKYILSRKLSMSAILLKLTRYSISEISNDYSFTSQQNFSRAFKRYFKVTPEFYRKSKFWDFRYYRPQHKVFDFKKINCQLIYLSKDRLLDNNSDDFKFFDISIPFDFKSNIAIEGLGYKNKKQIEIIKSLVDSSNDNLCVSYNYFLSSKVKNKITVKYNIKYIHDYNFSFNKEGLKYYLFSFLGSWEDYMILSNIIYMRELPLLQAKRRDGYDIEIFNSGKLDKNICSLNYLIPII MSHQKIIQDLIAWIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGYVSQQTFSRVFRRQFDRTPSDYRHRL 266.36 gnl|BL_ORD_ID|1978|hsp_num:0 2066 Z1_00087 Type I secretion system ATP-binding protein PrsD Loose 710 124.8 efrB 27.94 3003949 protein homolog model n/a n/a macrolide antibiotic; fluoroquinolone antibiotic; rifamycin antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MPQIKYNNEITSIIKERRKVFLSIGLFTALINILMLVPSIYMLQVYDRVLPSGNEMTLLMLTIIMLALFIFMGGLEYLRSIIVIRMSNKLDLSLNSRIYTAAYREKLNKIANINPTLALTDLITLRQFITSHAIFTFFDLPWFPIYLLVITLFNPWLGLFALCGALILFALAILNEYLSKNHLKKANNFANQAQLIQSHHLEHPQTIEAMGMLSQLRKQWQTSHFKYLQAQTQASDNAAGINAITKVTRMALQSLMLGLGGWLAIDNTISPGMMIAGSILLGRALAPIEQVINVWKSWDSSKAAYNRLTTLLKTYPQENKKMALPKPQGQLLVNIDEAVYPHSDRILLNNINFALLPGDILGIIGPSASGKSSLAKFIVGIWQVKKGIVRLDNADIFQWSKEEIGPHIGYLPQEIALFPGTIAENIARFTEVDPQKVIQAAKMAHVHEMILRFPQGYETQIGAHGEGLSGGQKQRIALARALYGDPTLVVLDEPNSNLDDLGIRALTQAIETLKQHKKTVILITHQKQLLSVTNKLLVIFDGNTKLFGPTASVIAELNNPTITKTANTISSTPATSNNA LDTCRIFRRNAKSPVNIAKHAKFIRRLKWLCSENMTGFSVLKLYVRKKKPLKGFKQVNHRFKWFGFKASFISGLMLPLVQMTAYGTYIGVAVLGSYYVVAGVIVVGQLQAFIQYIWQISQPMGNITQLSAALQSASASTMRIFEILDEPEEELNEQDVPLPEPILGSVEFENVSFSYDPEKPLIRNLNFKVDAGQMVAIVGPTGAGKTTLINLLMRFYDVTEGAIKIDGIDTKKMNRSDVRSVFGMVLQDAWLYKGTIADNIRFGKLDATDYEVVDAAKTANVDHFIRTMPDGYEMEINSEGDNVSLGQKQLLTIARAVISDPKILILDEATSSVDTRLEALIQKAMDRVMEGRTSFVIAHR 159.94 gnl|BL_ORD_ID|2191|hsp_num:0 2422 Z1_00089 Outer membrane protein TolC Loose 850 124.0 OpmH 23.52 3003682 protein homolog model n/a n/a disinfecting agents and antiseptics antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MPASAVTLSDLYFLAIKHDPTFNAAVKEQVAGKEYENIGLSQLLPNISVNYKNNPRNWQRKAYPINIFQDKITTVEYQNYQSYSVNAIISQPLFDYTAFSEYKASIIKTLLADSHYQNKFSELIIRLIDNYIQVAYTQDKLLLNQAQQEIYQKQLASSQRLFELGEGTKTDIAEIETRLYLTQSQYTDLQLEIEKAKNKLSAMIGSQLPTHEHIAKLTDTKFVLQSLAPDDYSTWEKNAIQNNLKIQSARHEMAIAKQEIEKNRGEFFPTVQFYAAYSSSNSDSNNTINQKYQSANVGFYVSMPLFNGGKTTASMRQSTAKYQMSAFERDAIIQNIMQELRYQYQICSTSHIKLMAFEQAVSSAKLQLNATRKSYIGGQRTMVDVLNAEELLYRAQQDLIKAKYDYIQAWALLHQYTNTLDIEKIKIIENYFQ MLRRLSLAAAVAAATGVAWAAQPTPLPTKTDLISVYKEAVDNNADLAAAQADYLARKEVVPQARAGLLPQLGAGARVGDTRIAFDERPATVKRNSQVVQATLSQPLFRADRWFQWQAAKETSDQARLEFSATQQDLILRSAETYFTVLRAQDNLATSKAEEAAFKRQLDQANERFDVGLSDKTDVLEAQASYDTARANRLIAEQRVDDAFQALVTLTNRDYSAIEGMRHTLPVVPPAPNDAKAWVDTAVQQNLRLLASNYAVNAAEETLRQRKAGHLPTLDAVAQYQKGDNDALGFANSAANPLVHYGKYVDERSIGLELNIPIYSGGLTSSQVRESYQRLNQSEQSREGQRRQVVQDTRNLHRAVNTDVEQVQARRQAIISNQSSLEATEIGYQVGTRNIVDVLNAQRQLYAAVRDYNNSRYDYILDTLRLKQAAGTLSPADLEALSAYLKQDYDPDKDFLPPDLAKAAAEQLQSKPRQQY 89.83 gnl|BL_ORD_ID|2009|hsp_num:0 2195 Z1_00090 Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase Loose 1000 391.0 ArnT 41.33 3005053 protein homolog model n/a n/a peptide antibiotic antibiotic target alteration pmr phosphoethanolamine transferase MNIAMTERYKWLLFFLFILLTYFIPLETRLLWQPDEIRYAEISREMLVSGNWSVPYLLDIRYFEKPVLGYWINCIAQWLFGESHFAVRIVVVTSTLLTGWLIYKAAMVVWRNSALAFNAMTVFLSSFLVLAIGTYNILDPIVTLFVTAAMYSFLVALSTPNKKGKIIAYMGIGFFCALGFLTKGFIAVVLPALVFLVMAISQARFKEVVCYSSIALLALAITAGPWVITVALQAPDYWNYFFWVEHVQRFIAKESARSQPTWFYIPIVILGVLPWLGFLFGALKSAFSLKKGTLYFLLWFALFFAFFSASKGKLLTYMLPCFVPLSILIAHYIEELKDRPDEKISKVNASINIAFGLMGISAVIYSLYSAKFALYDTNETLKIVLAISGFLFWSVIGAGALFRQTQFLTMFCSIGLSLVIGYAIPEKIESRSTPENIIQRYYEPLSNKSYLLTDEVGIGTSLAWGLKRTDIRLTETKGELAYGLNYPDVKNKYYSLEQLLALIEANQYKGVAIVLVRPDRKQILTKLTTLKEKPIVEKEGDLTLVFFN MKSIRYGVSLIALFALYYLLPLNFRLLWQPDETRYAEISREMLATGDWVVPHFLGLRYFEKPIAGYWINSIGQWLFGHNNFGVRFGSVFAITMTALLVAWLAWRIFRDKRVAILSLIIFLTAMLVYAIGTYAVLDPMITLWLALAMCSFWGAVQAHSRSGKILGYVLLGVACGMGVMTKGFLALAVPVVGVLPWVIARKRWREVLTYGWLAVIVCTLVVLPWGLAIAQREPDFWRYFFWVEHIQRFAEKDAQHKAPFWYYIPFLIAGSLPWLALLPGALKRGWLERDEARGALYLLGWVAMPFLFFSIAKGKLPTYILPCFAPLSILMARYALEAAKTGAKALRINGMINLGVGLLGLIAVLVVSPWGFMHKPVWTKIELYKCLLAAIAFAVWALMGWLAMKDSGRRWSLAALCPLGLALLVGFAIPDRVIDSKQPQFLVDIVSESLQPSRYVLTNNVGIAGGLAWELKRSDIIMFDKQGELKYGLDWPDAQGSFVSQAGFADWLAAHRQQGPVSLVLLMDKGESMLDLPLPKPDNAYELGRVVFLQYLPQ 99.46 gnl|BL_ORD_ID|2792|hsp_num:0 3795 Z1_00116 HTH-type transcriptional regulator FarR Loose 270 45.1 mgrA 22.79 3000815 protein homolog model n/a n/a fluoroquinolone antibiotic; cephalosporin; penam; tetracycline antibiotic; peptide antibiotic; disinfecting agents and antiseptics antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump MHESLTIALLQARESAMGFFRPVLKEHNLTEQQWRIIRVLADKRSIDFHELAQKTCILRPSLTGILIRMERDELICRLKPVSDQRKLFVSLSTNGQNLYDKIQPKIEEGYQLLEQKFSTEKLQHLSILLKELIALNPENSHSTEK MSDQHNLKEQLCFSLYNAQRQVNRYYSNKVFKKYNLTYPQFLVLTILWDESPVNVKKVVTELALDTGTVSPLLKRMEQVDLIKRERSEVDQREVFIHLTDKSETIRPELSNASDKVASASSLSQDEVKELNRLLGKVIHAFDETKEK 98.64 gnl|BL_ORD_ID|134|hsp_num:0 154 Z1_00127 Staphyloferrin B transporter Loose 750 75.1 pmrA 24.22 3000822 protein homolog model n/a n/a fluoroquinolone antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MRVTGSVIFIVQFLFIVQLLSMGAMEMSGPFWPLHLESMASTELLSIVGTGVYIAPMLGVMLTSTFWGRIGDKTGNKVMMIRALMGLALTQLGLAFANDVWVILLLRFLQGTCAGYIAPAQAYGIAMIPIAQRTRLLAWLQVSTNAGSLAGAIAGGAILDLLSFFWINFGAFIICTLCALLVFFILPNDLPRYASSNCVTSSTNKAKAISSINHSVIVGLLTVLGLLLVSRMITQTPFSLYVSSVFNAPNWLTGGAYGLQATGVIVSASLWARWFEAHNISHALYRMVGIIAGCFIVTLLLAAVREISWFIGLYFLWGILLGATTPVLTALISRSTAESKQGYILGLVQSISQFASIVGIALGGGILVWPGLTTLFLCVAVMYCITLIITLKMSYSSKNTNQK MTEINWKDNLRIAWFGNFLTGASISLVVPFMPIFVENLGVGSQQVAFYAGLAISVSAISAALFSPIWGILADKYGRKPMMIRAGLAMTITMGGLAFVPNIYWLIFLRLLNGVFAGFVPNATALIASQVPKEKSGSALGTLSTGVVAGTLTGPFIGGFIAELFGIRTVFLLVGSFLFLAAILTICFIKEDFQPVAKEKAIPTKELFTSVKYPYLLLNLFLTSFVIQFSAQSIGPILALYVRDLGQTENLLFVSGLIVSSMGFSSMMSAGVMGKLGDKVGNHRLLVVAQFYSVIIYLLCANASSPLQLGLYRFLFGLGTGALIPGVNALLSKMTPKAGISRVFAFNQVFFYLGGVVGPMAGSAVAGQFGYHAVFYATSLCVAFSCLFNLIQFRTLLKVKEI 101.00 gnl|BL_ORD_ID|1928|hsp_num:0 2003 Z1_00134 Fe(3+) dicitrate transport ATP-binding protein FecE Loose 570 80.5 bcrA 27.19 3002987 protein homolog model n/a n/a peptide antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MNTGLNAGLRIEKLSTGYSKQEIIKELTVSLLPRGKITVLLGPNGSGKSTLLRALAGLNSAQGKLFLGDDELFSLSFSKRAEQVVYLPQTLPAGVHLSVLESILVARRALGEHRSHSANDEVIDLLEQLGISHLAMRYLDELSGGQKQLVGLAQSLIRRPSLLLLDEPLSALDLNYQFHVMELIARETKKRNMITVVVVHDINIALRHGEHVLMLKNGELVANGLPTEVITPEILADVYRVSARIERCSRGHPQVLIDGRINDI MSTIIKTTDLTKMYGSQKSVDHLNINVKQGDIYGFLGRNGAGKTTTIRMLLGLIKPTSGQIEIFGENFFKNKKEILRRIGSIVEVPGFYANLTARENLLINAKIIGIHKKNAIDEVLEIVGLQHETKKLVGKFSLGMKQRLGIARALLHYPELLILDEPTNGLDPIGIKEMRRLIHSLAKERNITIFISSHILSEIEQLVDHVGIIHEGKLLEEIPFDHLKKRNRKYLEFQLSDQNKAVVLMEQHFDIHDYEVHQDGIIRVYSHLGQQGKLNKLFVENGIDVLKITMSEDSLEDYFVKLIGGGTIG 86.27 gnl|BL_ORD_ID|316|hsp_num:0 345 Z1_00169 Transcriptional regulatory protein UhpA Loose 390 98.6 evgA 25.98 3000832 protein homolog model n/a n/a macrolide antibiotic; fluoroquinolone antibiotic; penam; tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump MINVALIDDHIVVRSGFAQLLMLEPDINIVGEYANGQEAWPYLLNDNIDVAVMDLSMPGESGLQLQSRLKQKRPDFRTIILSIYDTPAFVQSALDSGAHGYLTKRCGPQELVQAVRAVYQGGCYLCADAMKALRQTPEKEDALHSLTPREREIFNLLVQGINVKAIAVQLNLSHKTVHVHRANILGKLNCETTIDLVHFALNNQLITGTL MNAIIIDDHPLAIAAIRNLLIKNDIEILAELTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQVLETLRKRQYSGIIIIVSAKNDHFYGKHCADAGANGFVSKKEGMNNIIAAIEAAKNGYCYFPFSLNRFVGSLTSDQQKLDSLSKQEISVMRYILDGKDNNDIAEKMFISNKTVSTYKSRLMEKLECKSLMDLYTFAQRNKIG 102.94 gnl|BL_ORD_ID|939|hsp_num:0 1015 Z1_00174 sn-glycerol-3-phosphate import ATP-binding protein UgpC Loose 500 128.6 RanA 30.86 3005091 protein homolog model n/a n/a aminoglycoside antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MTQSHFVELKNIVKRFGTNTVIDTLSLSIPQGKMVSLLGPSGCGKTTVLRLVAGLEKPTEGKIFIDGEDVTDRSIQQRDICMVFQSYALFPHMSLGDNIGYGLKMLGRPKAEIKQRVAEALALVDLAGFEDRFVDQISGGQQQRVALARALILKPKVLLFDEPLSNLDANLRRSMREKIRELQQQFNITSLYVTHDQSEAFAVSDMVLVMNKGKIMQLGSPQTLYRQPASEFMASFMGDANLFPATLGADYVDIFNYRLPRPENFNSNKTEIRVGVRPEAITLSQQGEACQQCTIIHVAYMGPQYEVTVAWQNQTLLLQVNATQLQPNEGDSYYLQIHPYGMFILE MIEVKDLRKSFNDVEVLKGITTTFETGKINLVIGQSGSGKTVFLKCLLNVFDPSSGDILFDGRNLSIMGRTEKQEIRSEIGTVFQGSALFDSMTVEENISFPLDMFTNLTYTEKRKRVKEVIGRVHLENANTKFPSEISGGMQKRVAIARAIVNNPKYLFCDEPNSGLDPNTAIVIDELIKEITEEYNTTTIINTHDMNSVLTIGEKIVYLRKGVKEWEGNKDLIIKAENEHLIDFVYSSALFKQVRETMLRNNQTNL 134.11 gnl|BL_ORD_ID|2817|hsp_num:0 3825 Z1_00177 HTH-type transcriptional regulator DsdC Loose 550 105.5 NmcR 27.05 3003665 protein homolog model n/a n/a carbapenem; cephalosporin; cephamycin; penam antibiotic inactivation NmcA beta-lactamase MFGSSNVILRNKRLSSYQLARLHTFEATGRHLSFALAAEELSLTPSAISHRINTLEKELGIKLFNRFHRRIELTEEGERIYWALKKTLEDINQEILDIYNQEISGVLTVYSRPSIAQCWLVPRISDFTQRYPSIELNLLTGNDDINFRGYGIDLAIYFDDKHLKNLYCEDLISESIIPVCSPEYAARHELVGNIHHLANCTLLHDRQAWSNNSDFDEWRAWSEYMGLGLFPNKSNICFDRSDLAVIAAVNHSGVAMGRKRLIQKQLANNELIIPFDNCEFFCAQRYYLVTRDEKSNAKVQLFIQWLKKQILQGM MRARLPLNALRAFEASARYLNFTKAGLELHVSQAAVSQQVRTLEQMLGVALFTRVPRGLQLTDEGMHLLPSITEALQMMSSAMDKFHEGKIKEVLTIAVVGTFAIGWLLPRITAFLNENPWIDIRILTHNNVVNLAAEGIDASIRFGTGGWINTENILLFQAPHTVLCSPETSKKLYIPSDLKKVCLLRSYRKEEWNNWFKAAGIDPWTITGPIFDSTRLMIDAVKLGDYAALVPYHMFQKELNERSVAKPFEIYATLGGYWLTLQKSRVNHNSEALNVFKEWIIEHSREFVLKS 106.44 gnl|BL_ORD_ID|1908|hsp_num:0 2072 Z1_00194 Putative niacin/nicotinamide transporter NaiP Loose 750 48.1 tet(39) 29.2 3000566 protein homolog model n/a n/a tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MAVASETAKEPTVLSRRKLLCIAGMGWTFDAMDVGLLAFLLTALKEDWGLTAAQLGWIGSINSIGMAVGAFVFGIMADRKGRKPVFILTLLLFSLGCGLTALASSLMVVLILRFFIGMGLGGELPVASTLVSESVKAHERGRIVVLLESFWAVGWLIAALIAYFIIPDYGWRMAMLLSALPAVYALYLRSKLPEPSSTQLLLQNRLSLRQSMALIWSPQYRRSTLMLWVLWFCVVFSYYGIFLWLPSVAMLKGFSLIKSFQYVLIMTLAQLPGYFTAAWFIERYGRKFVLITYLAGTAISAYYFSVADSTTTLLVFGMLLSFFNLGAWGALYAYTPEQYPDGIRATGAGTATAIGRIGGILGPLMVGYLVQYQFDISTIFLIFSLSIVIAILAVMLLGKETKNRPLNSI MKKSLSVILITIFLDAVGIGLIMPILPELLRSLAGAEAGGVHYGALLAVYALMQFIFAPILGALSDRFGRRPVLIISIAGATADYLLMAAAPSLLWLYIGRIFAGITGANMAVATAYVSDITPAHERAKRFGLLGAVFGIGFIAGPVIGGVLGEWNLHAPFFAAAFMNGINLIMTAVLLKESKHSNKMTEKVQEQSILKKLSYLITQPNMAPLLGIFLIITLVSQVPATLWVIYGQDRYGWSIFIAGVSLASYGICHSIAQAFAIAPMVKRFGEKNTLLCGIACDAIGLLLLSIAVEEWVPFALLPLFALGGVAVPALQAMMSRGISDERQGELQGLLSSFNSLGAIIGPVLVTSLYFMTQASAPGMVWALAAILYVITLPLLLKYRLNKYSGVP 103.54 gnl|BL_ORD_ID|1040|hsp_num:0 1092 Z1_00196 putative ABC transporter ATP-binding protein YadG Loose 650 141.4 tetA(58) 29.36 3003980 protein homolog model n/a n/a tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MTYALELTELTKTYHNGVKALKGINLTVEAGDFYALLGPNGAGKSTTIGIISSLVNKSSGKVKVFGYDTDTDMVNAKRQLGLVPQEFNFNPFETVLQIVLNQAGYYGVPRKVALERAKTYLTQLDLWEKKDDRARFLSGGMKRRLMIARALMHEPKLLILDEPTAGVDIELRRSMWTFLQHLNAQGTTIILTTHYLEEAEMLCRNIGIIQHGELVENTSMKGLLSKLESETFILDLAAKSPLPELQNYQYRLVDTSTLEVDVKREQGLNGVFAQLNAQGIQVLSMRNKANRLEELFVHLVNEDHTETEKGERE MEHAYKKKIEPKPGDLAVEAYGLIKTFGDNRAVDGVDLNVRTGTIYGVLGPNGAGKTTTIRMLATLLRPDAGSARIFGHDVQAESQIVRQLIGVTGQYASVDESLSATENLIIFSRLLGLGRKEARRKAEELLEEFGLSEAAKRPLKNFSGGMRRRLDLAASLIAQPPLIFLDEPTTGLDPRTRSQMWDTIRRLVNTGSTVLLTTQYLEEADQLADRIAVIDYGRVVAEGTADELKMSVGTSSLHLTVEDSVDMDRACHTVEQVLGVHANVSPEAGKITAPMANAGLVTDLLIELRTAGIGLSEMSVQKPTLDEVFLTITGHGVKEDAAQESYESNDREVARV 91.25 gnl|BL_ORD_ID|2251|hsp_num:0 2517 Z1_00209 putative FMN/FAD exporter YeeO Loose 900 114.4 MdtK 24.77 3001327 protein homolog model n/a n/a fluoroquinolone antibiotic antibiotic efflux multidrug and toxic compound extrusion (MATE) transporter MHQSDVADRSLFSLSWPIFIDIFLHLATLLINTYMISHVSTAYLAAMGVGNQVFDLFITIFNFISVGCSVVIAQYLGAGKRDKASQAIHISIAFNFLLGFSSAIIILFFGYNILNVMNTPEHLVQDGYNYLHILGICLIPEAISIILAACLRVYGKSKAAMYVTLIANIVTVIGNMIVLYGFFGLPQYGLVGVAWSTVVGRIIAVVLLCGLLFYGLRIKFDIRLLVIWSKNMLAKILHIGLPAAGENLVWILHYMTASAFIGLMGEVPLAAQTLYFQLSLFLMLFGIAISIGNEILVGHLVGAKRFDEAFTRGFKSLKAGVLFTIGVVIIYWFMRDPILYSITEDQRIIDQLLPLFILSVFLEPGRTFNIVMVNALRAAGDAKFPLITAVCFMWGVAIPVGYFLGIKMEMGLIGIWIGFLCDEWLRGLTNAWRWRSRKWQAKRLDI MNVSTALRQAVVRTPWYAKRKSYKVLFWREITPLAIPIFLENTCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARAAARQSLVIMTLFAVVLAVVIHYFGSEIINIVAGEATPEVKGLALTYLELTVLSYPAAAIALIGSGALRGAGNTKIPLMINGGMNILNIIISSILIYGAFSWQGLGFAGAGLGLTISRYIGAVAIIWVLMIGFNPALRIPLKSYLKPLNFGIIWEVMGIGIPASIESVLFNGSKLLTQMFVAGMGTNVIAGNFIAFSVAALINLPGNALGSASTIITGKRLGTGQIGQAERQLRHVFWMSTIVLTAIAWGTAPFAGLFASFYTQEQDVKEVVKVLLWLNAAFMPIWAAAWVLPSGFKGARDVRFAMWVSMLGMWGCRVVAGYTLGIVLGMGVVGVWLGMFLDWAVRGALFYWRLISGRWLWRYPRVKRE 94.09 gnl|BL_ORD_ID|1653|hsp_num:0 1752 Z1_00225 HTH-type transcriptional regulator AcrR Loose 375 239.6 Escherichia coli AcrAB-TolC with AcrR mutation conferring resistance to ciprofloxacin, tetracycline, and ceftazidime 59.2 3003807 protein overexpression model n/a n/a fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic target alteration; antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MARKTKRQAQETRQQIIDAALRLFTVQGVSATSLSDIATEAGVTRGAIYWHFKNKVDLFTEACELTDLKIESLELEYQSKYPDDPLFVLRELLIYILTSIVEDPKHNALLEIYFHKCEFVGEMTPIVEIRRELCAADYSRIEQSLSRCIEKKQLPANLDLRRAAIMLRAMMTGLAENWLFSPESFSIKEESQYLVDSFIDMIKHSVNMRISALS MARKTKQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSESNIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVGEMAVVQQAQRNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYISGLMENWLFAPQSFDLKKEARDYVAILLEMYLLCPTLRNPATNE 99.53 gnl|BL_ORD_ID|2095|hsp_num:0 2306 Z1_00226 Multidrug efflux pump subunit AcrA Loose 670 451.8 Escherichia coli acrA 61.96 3004043 protein homolog model n/a n/a fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MRKNRGVLPLALLVLSGSLVIAGCGDKNQSAGGPPPAPAVGVVTLDAKPLTITTDLPGRTSAYRIAEVRPQVGGIILKRNYTEGSYVEAGTSLYQIDPAIFQATLNSAQADLAKAKANAEIARLTVERYKPLLGTNYVSKQDFDTATSQYAQAVAAVKAAEATVTNAKINLEYTKVTAPISGRSGKSTVTEGALVAPGQQVALTTVQQIDPIYVDVTQSSEDYLKLKNEIESGIVRQEQGKPVVHLTLTNGQSYAQKGHLEFSDVTVDESTGSITMRAIVPNPKGELLPGMFVRTKLENGIRQNAILIPQQAVIRTPRGEATTMVVNKDNVVEVRTIEVSQAVGNKWLVNSGVQVGDRVIVSGLQKAKPEMKVTPQEENLDATASTEKSEPAKDPQ MNKNRGFTPLAVVLMLSGSLALTGCDDKQAQQGGQQMPAVGVVTVKTEPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFKEGSDIEAGVSLYQIDPATYQATYDSAKGDLAKAQAAANIAQLTVNRYQKLLGTQYISKQEYDQALADAQQANAAVTAAKAAVETARINLAYTKVTSPISGRIGKSNVTEGALVQNGQATALATVQQLDPIYVDVTQSSNDFLRLKQELANGTLKQENGKAKVSLITSDGIKFPQDGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGLNPNAILVPQQGVTRTPRGDATVLVVGADDKVETRPIVASQAIGDKWLVTEGLKAGDRVVISGLQKVRPGVQVKAQEVTADNNQQAASGAQPEQSKS 99.75 gnl|BL_ORD_ID|2329|hsp_num:0 2661 Z1_00227 Multidrug efflux pump subunit AcrB Strict 750 760.8 adeF 42.17 3000777 protein homolog model n/a n/a fluoroquinolone antibiotic; tetracycline antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MPKFFIDRPIFAWVIAIITMLAGLLALIKLPVAQYPTIAPPAISISAVYPGADATTVQNTVTQVIEQNMNGIDNMVYMSSTSDSAGMMNITLTFEAGTDPDIAQVQVQNKLQLAMPLLPQEVQQQGISVDKSSSSFLMVAGFISGDGSMSQDDIADYVGATIKDPLSRVTGVGETQLFGTQYAMRIWLDPDKLVKYNMTTLDVINAIKSQNNQVAAGQLGGTPPVPGQRLNVSIIAQTRLNTPEQFADILMKVNQDGSQVKLKDLGIVEMGAENYSTIARFNGLPAAGIGIKLATGANALDTATAVRAALADMEPFFPSGLEVVYPYDTTPFVKISIFEVVKTLVEAIMLVFVVMYLFLQNFRATLIPTIAVPVVLLGTFAILSAFGYSINTLTMFAMVLAIGLLVDDAIVVVENVERVMQEEGLSPKEATRKSMGQIQGALVGIALVLSAVFIPMAFFGGSTGAIYRQFSVTIVSAMVLSVFVALILTPALCATLLKPIPKGSHGVQTGFFGWFNRVFEKSSHHYTDSVSRTLRGTGRYLLIYVLLVAAMAIMFVRLPASFLPEEDQGVLLTMVQLPAGSTQEQTQDVLAQVNDYFNTKEKDVVKSVFTVSGFGFGGQGQNMGLAFVVLNDWDERKSDQDKVPAIVGRANQALSQIKEAFVYSFNIPAIVELGSAGGFEFELIDNANLGHEKLMEARNQLLGMAAQEPQMLTGVRPNGQEDTSQYRLYIDLEKAQAQGVAVSDIYSTLGTMFGGSYVNDFIDRGRVKKVYVQAESQFRMLPQDIANLYVRNNAGQMVPFSSFIDTSKDPWLYGSPRLERYNGLPAVQIQGSATPGQSSGDAMLMMEQLASKLPSGIGYEWTGMSYQERLSGNQAPALYTISLIVVFLCLAALYESWSVPFSVMLVVPLGVIGALAFTTLRGLENDVYFKVGLLTTIGLSAKNAILIVEFAKDLMEKEGKGLVEATLDSVRMRLRPILMTSLAFMLGVIPLVLSNGAGSGAQNSVGTGVFGGMIAATSLAIYFVPIFFVVIRRRFAKKNEDLEHPNYPHQTK MNISKFFIDRPIFAGVLSVLILLAGLLSVFQLPISEYPEVVPPSVVVRAQYPGANPKVIAETVASPLEESINGVEDMLYMQSQANSDGNLTITVNFKLGIDPDKAQQLVQNRVSQAMPRLPEDVQRLGVTTLKSSPTLTMVVHLTSPDNRYDMTYLRNYAVLNVKDRLARLQGVGEVGLFGSGDYAMRVWLDPQKVAQRNLTATEIVNAIREQNIQVAAGTIGASPSNSPLQLSVNAQGRLTTEQEFADIILKTAPDGAVTRLGDVARVELAASQYGLRSLLDNKQAVAIPIFQAPGANALQVSDQVRSTMKELSKDFPSSIKYDIVYDPTQFVRASIKAVVHTLLEAITLVVVVVILFLQTWRASIIPLLAVPVSIIGTFALMLAFGYSINALSLFGMVLAIGIVVDDAIVVVENVERNIEAGLNPREATYRAMREVSGPIIAIALTLVAVFVPLAFMTGLTGQFYKQFAMTIAISTVISAFNSLTLSPALAALLLKGHDAKPDALTRIMNRVFGRFFALFNRVFSRASDRYSQGVSRVISHKASAMGVYAALLGLTVGISYIVPGGFVPAQDKQYLISFAQLPNGASLDRTEAVIRKMSDTALKQPGVESAVAFPGLSINGFTNSSSAGIVFVTLKPFDERKAKDLSANAIAGALNQKYSAIQDAYIAVFPPPPVMGLGTMGGFKLQLEDRGALGYSALNDAAQNFMKAAQSAPELGPMFSSYQINVPQLNVDLDRVKAKQQGVAVTDVFNTMQIYLGSQYVNDFNRFGRVYQVRAQADAPFRANPEDILQLKTRNSAGQMVPLSSLVNVTQTYGPEMVVRYNGYTSADINGGPAPGYSSSQAEAAVERIAAQTLPRGIKFEWTDLTYQKILAGNAGLWVFPISVLLVFLVLAAQYESLTLPLAVILIVPMGILAALTGVWLTAGDNNIFTQIGLMVLVGLACKNAILIVEFARELEMQGATAFKAAVEASRLRLRPILMTSIAFIMGVVPLVTSTGAGSEMRHAMGVAVFFGMIGVTFFGLFLTPAFYVLIRTLNSKHKLHSAAVHEAPLASPHDH 99.34 gnl|BL_ORD_ID|133|hsp_num:0 153 Z1_00234 Multidrug resistance-like ATP-binding protein MdlB Loose 1100 288.5 tetB(60) 32.19 3004036 protein homolog model n/a n/a tetracycline antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MTINNNKSIKTLLPALKRLLAYGKTYRKPMTLGVVMLWVAAIAEVGGPLLISYFIDAKVATHQVEWRGALGLAAAFILLQIIAALLHYYQTIVFNYAAVGVVQQLRADVMSAALKQPLSAFDNQPVGQLISRVTNDTETIKDLFVNVFPALFRAIALVVVMLIAMFLLEWQMALVAMTIFPAVIGVMMLYQRLSTPIVRNVRHYLANINDGFHEVINGMSVIQQFRQQARFGKRMSDDSWQHYQARMKALKLDGLLLRPLLSMLSALVLCGLLILFGYQGSAVIGVGVIYAFISYLGRLNEPLITLTSQQSLLQQAVVSGERVFELMDAPMQQYGNASYTINQGDIAINGLWFAYLKQQWVLKEINLDIPARHFVAFVGHTGSGKSTLASLLMGNYPWQKGHIYLDNHPLECYSHQALRSGIAMVQQDPVLLSGTLRDNITLGRHCSEAHLWQVLATVQLNSWVKTLPDGLETPLGEQGSRLSAGQKQLLALARVLLFPPRILILDEATANIDSGTEQAVQKALTEIREKTTLIVIAHRLSTIIDADEIVVLHRGEIVEQGKHAQLLAQKGRYYNMYQLQQVKESLQVQKPAVVE MRTMKRLLSYLRYEKKGVLIGLFCLLLSTGATLTGPLVAKHIIDNVITPMGQAHDFKAGGLLLWVGIYVTVNLVGVAGAYLNRVYMKTLSNRIAKRIRDEVFEHVQTLPVSYFDHLPAGKVVSRITSDTESVRANFYVSGISTLFSTIVMLVGVYITIFLLNATLGLVLLFLVPVMILWQRTVATKQKKYYSENRELYSQLSGQLNESIQGAGIVQAFQQEEKIVAEYDATATSWVEVGRKELILESYFSWSLVGMLRNITHFGVIYYFSMQFIGGTLGISAGLLYAFIDYINRIYEPIQTFMNVVSGFQQSMAAGDRVFELMDTPSEESGEELFTFDEGCIEFKDVSFEYTAGVPVLKHLNFTVEPGQTVAFVGHTGSGKSSIMNLLFRFYDPTSGAIFIDGKNTRDFNRRSVRSEMGIVLQDPYLFTGTIASNVGLNNESIEPETIKEAIIKVGGGHLLTKSDKGLDYEVKEKGMDFSSGERQLISFARAIVFDPKILILDEATSHIDTETEEIIQNAINVVKEGRTTFMIAHRLSTIAHADQIFVLDKGEIVERGTHDELLQLQGQYAEMVALQKG 102.76 gnl|BL_ORD_ID|2315|hsp_num:0 2646 Z1_00235 putative multidrug resistance ABC transporter ATP-binding/permease protein YheI Loose 1100 320.1 tetA(60) 34.45 3004035 protein homolog model n/a n/a tetracycline antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MALFSQLSWYFISEWRRYVGAIFLLMVIAVLQVIPPKIVGIIVDGVDSHSLSFQQIMGWIGIMVLIALAVYLLRYIWRLWLFGASYQLAVKLRMQIYRQLSLQSSAFYQRYRTGDLIARTTNDVDKVVFAAGEGVLTLVDSMVMGLAVLVMMSIQLSWQLTLISLLPMPLMAILIKRYGDKLHHRFKSAQALFSSLNNQAQESLSSIRMIKSFGLEQQHASRFETVAKETGRQNMRVAKVDALFDPTIFMAIGFANLLAVAGGSYFVLNGTMTLGELTSFVMYLGQMIWPMLALAWMFNIVERGSAAYSRINALLNEQPAMIDGQLSLMHQKGTLAVDIKAFHYPKQQVDVLKNIHFTLSPGEMLGICGMTGAGKSTLLALIQRLYDVSEGDIRFQSVPLYQLKLDEWRGRLAVVNQTPFLFSDTIAGNIALGRPDATKEEIEAVAKIANIHDDILNLPEGYLTQVGEKGVMLSGGQKQRISIARALLLDAEILLLDDALSAVDGQTEYQILQNLAQWRKEKTIIISAHRLSALVDATNILVLKQGEIIEQGTHQTLIAVPGWYQDMYHYQQLEAALDDDK MNDLLKVIINFIKKHPMRYLVSFILMIGSSIAAVYPARIIGQVVDKIVASELNAEWLGTQLVILVGIILVAYITESIWTYFIFIGYYEIQKELRVKLLRNNLRKKIPFYAHFRTGEIITRSSEDVTTIGDMMGFGMFALMNSTLLMSVSIYMMVTTISLPLTIAAILPLPILSYLVYKWGFDLEEEYNKAQNAVSQLNNEVLEMIDGTYVIRAYGQEDAMMDEFRAKTKKAMKQNIIVTEIESRFIPLAQLFMMISFTIALFYGGYLVSTGAILVGDVIAFQVYMGAIMWPMFMIGDIITNYKRGKVATERINEVLKHDDEIERGGTKTLETIESIEFKDFHFMYPGEEAPLLKEINLTLRKGETLGIVGKTGSGKTTLLMQLLHQFPYRGEKLLINGEPLIDYDTQSVAGHLAYVPQEHTLFSRTIRENMLFGKEDATDDEIWEALTLASFEGDVKRMPDELDTMVGEKGVSLSGGQKQRLSIARAFLRNRECLILDDALSAVDAKTEREIISHLQQERGGCMNIISAHRLSAIRHADEIIVMNEGRISERGTHEELLEQRGWYYEQYLTQEMEEEIE 100.35 gnl|BL_ORD_ID|2318|hsp_num:0 2645 Z1_00256 Inner membrane transport protein YajR Loose 850 176.8 hp1181 30.61 3003964 protein homolog model n/a n/a fluoroquinolone antibiotic; tetracycline antibiotic; nitroimidazole antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MNDNKMTPLERKATWGLGAVFSLRMLGMFMVLPVLTTYGLQLQHATESLIGLAIGIYGLTQAIFQIPFGFFSDKFGRKSMIVFGLIIFIVGSIIAALSDSIYGIIIGRALQGAGAISAAVMALLSDLTREQNRTKAMAFIGISFGITFALALVLGPILTHIFGLQGLFWGIALLAFCGIMITLITVPNSEHHILNRESSFVRGSVKKVLFDAQLLKLNVGIFSLHTLLMAAFVALPLIMHNAGLVNEKHWVVYLVTMLIAFISVLPFIIYAEKKRKMKQVFLLCIFLLIIAQAIFMISGTSLWLIILGIQIFFIGFNIMEALLPSLISKEAPAGYKGTAMGIYSTSQFLGVALGGILGGWLYQHYDAQAVFAGCLLIGLVWFAISLTLRQPPYVSSLRIELPAHLSNAQQQQLEQKFKQQPGVNEVVIMVHEQSAYIKVDTKQTPRATLESLVLGV MFKKIFPLALVSSLRFLGLFIVLPVISLYADSFHSSSPLLVGLAVGGAYLTQIVFQTPMGILSDKIGRKVVVMVCLLLFLAGSLVCFIANDIVWLVIGRFIQGMGALGGVISAMVADEVKEEERTKAMAIMGAFIFISFTISMAIGPGVVAFLGGAKWLFLLTAILTLLSLLMLLKVKDAPKISYQIKNIKAYQPNSKALYLLYLSSFFEKAFMTLIFVLIPLALVNEFHKDESFLILVYVPGALLGVLSMGIASVMAEKYNKPKGVMLSGVLLFIVSYLCLFLADSSFLGKYLWLFIVGVAFFFIGFATLEPIMQSLASKFAKVHEKGKVLGQFTTFGYLGSFVGGVSGGLSYHHLGVSNTSLIVVALGLIWGLSLFLLNNPSKQKNVYFPLDAYNEEQFETLEDKIIEWYVNISEEIIIVKYNSDHISEEEIIHLAQNFRK 102.93 gnl|BL_ORD_ID|2199|hsp_num:0 2430 Z1_00267 Ribose import ATP-binding protein RbsA Loose 1280 99.8 macB 31.28 3000535 protein homolog model n/a n/a macrolide antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MEALLELKNIDKSFPGVKALSGATLRIYPGRVMALVGENGAGKSTLMKVLTGIYQKDAGEIIYQGERCSFNGPKSSQEAGIGIIHQELNLIPELTIAENIFLGREFTRAFGAIDWKKMYAEADKLLARLNLPYRSHRLVSELSIGDQQMVEIAKVLSFGSKVIIMDEPTDALTDTETRSLFSVITELRNQGCGIVYISHRLKEIFDICDDVTVLRDGQFIGEKPVSSLQEETLIEMMVGRKLEDQYPRIHIPAGKTKLNVSHLSGADIHDVSFSLYENEILGISGLMGAGRTELMKMIYGALPKTQGSVALEGKICQIKKPADALAQGIVYISEDRKRDGLVLGMSVKENMSLTALPYFSRTMGILNHKEEQLTVSDFIKLFNIKTPSINQIIGFLSGGNQQKVAIARGLMTRPKVLILDEPTRGVDVGAKKEIYQLINKFKQEGLSIILISSEMPEVMGMSDRILVMHEGRISGEFSANNVTQEMLMAAAVGKQYGATVGV MSLIECKNINRYFGSGENRVHILKDISLSIEKGDFVAIIGQSGSGKSTLMNILGCLDTAGSGSYRIDGIETAKMQPDELAALRRERFGFIFQRYNLLSSLTARDNVALPAVYMGMGGKERSARADKLLQDLGLASKEGNKPGELSGGQQQRVSIARALMNGGEIIFADEPTGALDTASGKNVMEIIRRLHEAGHTVIMVTHDPGIAANANRVIEIRDGEIISDTSKNPEIPASNVGRIQEKASWSFYYDQFVEAFRMSVQAVLAHKMRSLLTMLGIIIGIASVVSVVALGNGSQKKILEDISSMGTNTISIFPGRGFGDRRSGKIKTLTIDDAKIIAKQSYVASATPMTSSGGTLTYRNTDLTASLYGVGEQYFDVRGLKLETGRLFDENDVKEDAQVVVIDQNVKDKLFADSDPLGKTILFRKRPLTVIGVMKKDENAFGNSDVLMLWSPYTTVMHQITGESHTNSITVKIKDNANTRVAEKGLAELLKARHGTEDFFMNNSDSIRQMVESTTGTMKLLISSIALISLVVGGIGVMNIMLVSVTERTKEIGIRMAIGARRGNILQQFLIEAVLICIIGGLVGVGLSAAVSLVFNHFVTDFPMDISAASVIGAVACSTGIGIAFGFMPANKAAKLNPIDALAQD 77.95 gnl|BL_ORD_ID|447|hsp_num:0 487 Z1_00280 Sec translocon accessory complex subunit YajC Loose 200 88.2 YajC 46.9 3005040 protein homolog model n/a n/a fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; oxazolidinone antibiotic; glycopeptide antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MSFFISDAVASAGQAAPEASFMSILPMLVIFILIFYFMILRPQQKRTKEHRKLMESIGKGDEVLTTGGLIGRVVKVSDNGYIVVALNETTEVTIKRDFVAAVLPKGTMKAI MSFLIPAAYADAAAPAAAGPAGTGFEWVFLVGFLVIFYLMIWRPQAKRAKEHKNLLGNLQKGDEVVTSGGIAGKVTKVADDFVVVEVSDNVELKFQKAAIAATLPKGTLKAI 99.11 gnl|BL_ORD_ID|2780|hsp_num:0 3783 Z1_00297 Phosphate regulon sensor protein PhoR Loose 890 113.2 cpxA 31.48 3000830 protein homolog model n/a n/a aminoglycoside antibiotic; aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MLERLSWKALVWGLFLFCLPAFVLSLFIGHLPWLLVVSLLSALIWHAYNLMKLSKWLWLDRSVLPPEGKGGWEPIFYGIRQTQQRNRKRRRELGDLIKRFRSGAESLPDAVVMITNEGNIFWCNSLAQHLLGFRWPDDNGQNIFNLLRYPDFLHYFTVADFSRPLTIALNNGAIVEFRVMPYADDQRLMVARDVTEKNKLENSRRDFFANVSHELRTPLTVIQGYLEMMEENTAENPAEHKVIKTMQEQAKRMDLLVQQLLQLSRIESAPHIDLNTVVDMPALLSVLEHDAHSLSQEQQNIIFDIDHKWAVRGNEEQLRSAVSNLVYNAINHTPEGTTIRVSWKKVPQGMLFSVSDNGPGISAEHLTRLTERFYRVDKARSRHTGGTGLGLAIVKKSLQHHHSILNIESKVGVGSTFSFIMPQTLLTEKK MIGSLTARIFAIFWLTLALVLMLVLMLPKLDSRQMTELLDSEQRQGLMIEQHVEAELANDPPNDLMWWRRLFRAIDKWAPPGQRLLLVTTEGRVIGAERSEMQIIRNFIGQADNADHPQKKKYGRVELVGPFSVRDGEDNYQLYLIRPASSSQSDFINLLFDRPLLLLIVTMLVSTPLLLWLAWSLAKPARKLKNAADEVAQGNLRQHPELEAGPQEFLAAGASFNQMVTALERMMTSQQRLLSDISHELRTPLTRLQLGTALLRRRSGESKELERIETEAQRLDSMINDLLVMSRNQQKNALVSETIKANQLWSEVLDNAAFEAEQMGKSLTVNFPPGPWPLYGNPNALESALENIVRNALRYSHTKIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAIVETAIQQHRGWVKAEDSPLGGLRLVIWLPLYKRS 94.09 gnl|BL_ORD_ID|132|hsp_num:0 152 Z1_00298 Phosphate regulon transcriptional regulatory protein PhoB Loose 420 174.1 mtrA 42.67 3000816 protein homolog model n/a n/a macrolide antibiotic; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MARRILVVEDETAIREMICFVLEQNGFQPIEAEDYDTALSFLIDPYPDLVLLDWMIPGGSGIQVIKQMKRENNTRDIPIIMLTAKGEEEDKVKGLETGADDYVIKPFSPKELVARVKAILRRLSPMSAEDVIEFNGLSLDPVSHRVTSQDKPIDMGPTEFKLLHFFMTHPERVYSREQLLNYVWGTNVYVEDRTVDVHIRRLRKAIEQDGHDRMIQTVRGTGYRFSARF MDTMRQRILVVDDDASLAEMLTIVLRGEGFDTAVIGDGTQALTAVRELRPDLVLLDLMLPGMNGIDVCRVLRADSGVPIVMLTAKTDTVDVVLGLESGADDYIMKPFKPKELVARVRARLRRNDDEPAEMLSIADVEIDVPAHKVTRNGEQISLTPLEFDLLVALARKPRQVFTRDVLLEQVWGYRHPADTRLVNVHVQRLRAKVEKDPENPTVVLTVRGVGYKAGPP 100.44 gnl|BL_ORD_ID|1434|hsp_num:0 1559 Z1_00307 hypothetical protein Loose 700 54.3 Klebsiella pneumoniae OmpK37 24.46 3004122 protein homolog model n/a n/a monobactam; carbapenem; cephalosporin; cephamycin; penam; penem reduced permeability to antibiotic General Bacterial Porin with reduced permeability to beta-lactams MGILIMKSLKPLAALVGLLVLSGSANAVNVYNDKGTRFDVNGQFRLKTQVTSQNHEMKMNDDGSRIGFFGSHELTNDIKVFGKLEWGSDTQKTNSDNPKSNFEMYNRVGYVGFSHRDYGQIQFGRTYIPIDWVKKSSYGYGNTGVFYFSDVLGRAVGYSNGYADGKGVGKNNFMTRLPQTIFIETNRYEGFKLAGTITGKTGDDNTRTTGDITRAYSIVGFYKSTFGLEFDAGYSAAKGEATHSSKSTVRGKTPENSILAFGAEYFFPGREFSIGIDYGQSRGKNSGLTLASNASEKDYRWNSVKGDWKANLYGVGVKWHWDRIESGMYAGYYLRDGDANTFNYKKETYTVGVDKRFAVSKYNNLRLFAEMAYDDARSENPAYEDKKQYIFETGMRLYF MKRKVLALVIPALLAAGAAHAAEIYNKDGNKLDLYGKVDGLHYFSSDSKKDGDQTYLRFGFKGETQINDILTGYGQWEYNVQANNTETSSDQAWTRLAFAGIKVGDYGSFDYGRNYGVLYDVEGWTDILPEFGGDSYTYADNFMAGRANGVATYRNSDFFGLVEGLNFALQYQGKNEGQNAQDINVGTNNRSSDSDVRFDNGDGFGLSTSYDFGMGISAAAAYTSSDRTNDQMTQTNARGDKAEAWTAGLKYDANDIYLATMYSETRNMTPYGNDGVANKTQNFEVTAQYQFDFGLRPAISYLQSKGKDLYNNGRYADKDLVKYMDVGATYYFNRNMSTYVDYKINLLDGNDKFYEDNGISTDNIVALGLVYQF 106.68 gnl|BL_ORD_ID|2634|hsp_num:0 2785 Z1_00336 Isoleucine--tRNA ligase Loose 2000 358.6 Staphylococcus aureus mupA conferring resistance to mupirocin 28.88 3000521 protein homolog model n/a n/a mupirocin-like antibiotic antibiotic target alteration antibiotic-resistant isoleucyl-tRNA synthetase (ileS) MSDYKNTLNLPETGFPMRGDLAKREPEMLSRWYKEGLYQAIRQAKSGKKTFILHDGPPYANGNIHIGHSVNKILKDIIIKSKGLSGFDSPYIPGWDCHGLPIELKVEQIVGKPGEKVSAAQFREECRKYAYEQIEAQKKDFIRLGVLGDWDKPYLTMDYKTEANTIRALARIIANGHLLKGAKPVHWCTACGSSLAEAEVEYYDKTSPSIDVRFRAVDSNAVAAKFGVVTDKPISLVIWTTTPWTLPANRAIALNGEFNYALVSFDDECVILAADLVEHVMKRIGVTDWAVLGECKGSDLELLRFNHPFMGFDVPAILGDHVTLDAGTGAVHTAPGHGPDDFVIGQKYGLEVANPVGPNGCYLPNTYPTLDGVFVFKANDVIVELLKEKGALLHHEAMQHSYPCCWRHKTPVIFRATPQWFIGMDKNGLRQQSLKEIKGVKWIPDWGQARIESMVENRPDWCISRQRTWGTPMSLFVHKETQEPHPRTLELMEEVAKRVEVSGIQAWWDLDIRELLGDEADDYMKTPDTLDVWFDSGSTHSTVVDARPEFHGNSADLYLEGSDQHRGWFMSSLMISTAIKGKAPYREVLTHGFTVDGQGRKMSKSIGNTVSPQDVMNKLGADILRLWVASTDYTGEIAVSDEILKRSADTYRRIRNTARFFLANLNGFDPAKHQVKPEEMVILDRWAVGRAKAAQEDILKHYENYDFHNVIQRLMQFCSVEMGSFYLDIIKDRQYTAKSDSVARRSCQTALYHIIEALVRWMAPIMSFTADEIWAQLPGERAKFVFTQEWYTDLFGLEASETLNDEYWAELLAVRSEVNKVLEQARTDKQLRGSLEAAVTLYADKALAEKLNALGNELRFVLLTSQATVADIHDAPENALASDMAGLKIVLSKAQGEKCPRCWHYATDIGQVAEHADLCGRCVTNVAGNGEERKFA MTKKYLNTQNEISAFWNTQKIFKKSIDNRKGQESFVFYDGPPTANGLPHAGHVLGRVIKDLVARLKTMQGFYVERKAGWDTHGLPVELEVEKKIGIKGKQDIEKYGIENFINECKKSVFNYEKEWRDFSKDLGYWVDMDSPYITLENNYIESVWNILSTFHKKGLLYKGHKVTPYCTHDQTALSSHEVAQGYKNVKDLSAVVKFQLTNSKDTYFLSWTTTPWTLPANVALAINKDLNYSKIRVENEYYILATDLINSIITEKYEIIDTFSGSNLINLKYIPPFESDGLVNAYYVVDGEFVTNSEGTGIVHIAPAHGEDDYQLVLERDLDFLNVITREGVYNDRFPELVGNKAKNSDIEIIKLLSKKQLLYKKQKYEHNYPHCWRCGNPLIYYAMEGWFIKTTNFKNEIINNNNNIEWFPSHIKEGRMGNFLENMVDWNIGRNRYWGTPLNVWICNDCNHEYAPSSIKDLQNNSINKIDEDIELHRPYVDNITLSCPKCNGKMSRVEEVIDVWFDSGSMPFAQHHYPFDNQKIFNQHFPADFIAEGVDQTRGWFYSLLVISTILKGKSSYKRALSLGHILDSNGKKMSKSKGNVINPTELINKYGADSLRWALISDSAPWNNKRFSENIVAQTKSKFIDTLDNIYKFYNMYNKIDHYNPNNEITKSRNTLDNWALSRLNTLIKESNIYVNNYDFTSAARLINEYTNTISNWYIGDSRGRFWEQGISNDKKDAYNTLYEILTTLSRLVAPFVPFISEKIHYNLTGKSVHLQDYPQYKESFINQALEDEMHTVIKIVELSRQARKNADLKIKQPLSKMVIKPNSQLNLSFLPNYYSIIKDELNIKNIELTDNINDYITYELKLNFSSVGPKLGNKTKNIQTLIDSLSEYDKKSLIESNNFKSLSSDAELTKDDFIIKTLPKDSYQLSEDNDCVILLDKNLSPELIREGHARELIRLIQQLRKKKNLPINQRIDIYIGVTGELLESIKTNKNMFKENFVIKNIHLNVIDEYENTIHFNNKEIKISLLY 91.41 gnl|BL_ORD_ID|4708|hsp_num:0 2270 Z1_00337 Bifunctional riboflavin kinase/FMN adenylyltransferase Loose 450 155.2 mreA 33.55 3007050 protein homolog model n/a n/a macrolide antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MELIRGIQNIRAQHHGCVLTIGNFDGVHRGHQALLKHLKQEASRRGLPTVVMTFEPQPLEFFLPEKAPARLTRLRDKIKYLAECGIDYLLCVKFDKQFAAQTPEEFVSSLLVDKLGVKFLAIGDDFRFGKNRAGDFHFLQQAGARYGFEVANTESYCDKGLRISSTAVREALFNDDLALAESLLGHPYSVCGRVVHGNQLGRTIGFPTANIPMKRLVAPVAGVYAVDVYLADHQSPLAGVANIGSRPTVKGKGVQLEVHLIDVNMDLYGRRIDVVLRKKLRNEQRFASLDALKQQIANDVAAARDFLLQRSES MMKIHYINDYKDIQAKEDCVLVLGYFDGLHLGHKALFDKAKKIATEKNLKIVVLTFNETPRLTFARFQPELLLHLTSPEKRSEKFQEYGVDELYLMNFTSHFSKVSSDLFIKKYIYGLRAKAAVVGFDYKFGHNRTSGDYLARNFKGPVYIIDEISEGGEKISSTRIRQLITEGNVEKANQLLGYEFSTCGMVVHGDARGRTIGFPTANLAPINRTYLPADGVYISNVLINGKYYRAMTSIGKNITFGGTELRLEANIFDFDGDIYGETIEIFWLKRIREMVKFNGIDDLVKQLKKDKEIALNWKKDSQTL 100.64 gnl|BL_ORD_ID|4761|hsp_num:0 5749 Z1_00351 Aerobic respiration control protein ArcA Loose 400 135.6 vanR gene in vanE cluster 34.22 3002924 protein homolog model n/a n/a glycopeptide antibiotic antibiotic target alteration glycopeptide resistance gene cluster; vanR MQTPHILIVEDEVVTRNTLKSIFEAEGYIVHEATDGNEMHNILSDHDINLVIMDINLPGKNGLLLARELREQVSVALMFLTGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSRTMNLANGTEERRLVESYKFNGWELDINSRSLISPTGEQYKLPRSEFRAMLHFCENPGKIQTRAELLKKMTGRELKPHDRTVDVTIRRIRKHFESTPDTPEIIATIHGEGYRFCGDLDE MAKILILDDEKEIVSLLSTLLSNEGYEVYEAMSGKESLEIIENNKIDLAILDVMLPDISGFDVLQSIREKQFFPVLMLTARGQDMDKITGLSMGADDYIVKPFNPFEVLARVKTQLRRYQTYNSQSIDETNEYAKNGLNISVNSRKVFLYDEEIKLTPIEFDILWYLCRNEGRVISSEELFEKVWKEDYLENNNTVMAHIAKIREKMHEKPRQPNIIKTVWGVGYTIEK 103.93 gnl|BL_ORD_ID|4683|hsp_num:0 691 Z1_00353 Right origin-binding protein Loose 200 133.7 Escherichia coli soxS with mutation conferring antibiotic resistance 60.58 3003511 protein overexpression model n/a n/a fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics antibiotic target alteration; antibiotic efflux; reduced permeability to antibiotic ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams MDQTNIIRDLLAWLDNNLDQPLSLDNVATKAGYSKWHLQRMFKEVTGQAIGSYIRSRRLSRAAVALRLTSRPILDIALQYRFDSQQTFTRAFKKQFDRTPALYRRSDEWCAVGICPPIKLDPQPLPKWEYVQLPEIKLIGIEQTCSHTLEQWANACSDMRQTFWQNYITKVNTIPHEVYGLHHTQHSDEHEDEQRVIYTTAVEPAYASFVEDDTAYEVILEAGDYIRFDFEGEAKRGAMQEFLFLIYGVCLPTMGLTRRKGHDIEKYYLKEVHYDNVMTAEPQDHIKRFEYYIPIKRETA MSHQKIIQDLIAWIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGYVSQQTFSRVFRRQFDRTPSDYRHRL 280.37 gnl|BL_ORD_ID|1978|hsp_num:0 2066 Z1_00358 Energy-dependent translational throttle protein EttA Loose 1200 363.2 TaeA 40.12 3003986 protein homolog model n/a n/a pleuromutilin antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MAQYVYSMLRVGKVVPPKRHILKNISLSFFPGAKIGVLGLNGAGKSTLLRIMAGIDTDIEGEARPQPGLKIGYLPQEPKLNPQQTVREAVEEAVSEVKNALNRLDEVYAAYADPDADFDQLAKEQGQLEAIIQSHDGHNLDNQLERAAEALRLPDWDAKIEHLSGGERRRVAICRLLLEKPDMLLLDEPTNHLDAESVAWLERFLHDYEGTVVAITHDRYFLDNVAGWILELDRGEGIPWEGNYSSWLEQKDARLEQEAATEAARHKSIQKELEWIRQNPKGRQAKGKARLARFEELNSVDYQKRNETSELFIPPGPRLGDKVLEVSHLTKSYGDRVLIDDLSFSIPKGAIVGIIGPNGAGKSTLFRMISGQEQPDSGTVTLGETVKLASVDQFRDSMDDSKTVWEEVSGGQDIMRIGNFEIPSRAYVGRFNFKGVDQGKRVGELSGGERGRLHLAKLLQVGGNMLLLDEPTNDLDVETLRALENALLEFPGCAMVISHDRWFLDRIATHIIDYQDEGKVEFFEGNFTEYEEYKKRTLGNEAIQPRRMKYKRITK MNILTVEQVTKSYGDKILFQDASFGMEDQDKIGIIGVNGTGKSTFLRVIAGLEPPDSGKISMGNRIRVRYLAQNPEFDPDKTVLQQVFEGDLPEMKAVREYTETMELLELHPSHEELQQKLLKLNQTLETLQAWQLESDAKTILSKLGIRNYEAKMGTLSGGQRKRVALAAALIQPSDLLILDEPTNHIDNESVAWLEQYLQKRRGALLMITHDRYFLDRVANVMLELDHGRLFRYEANYSRFLELKAEREEREAASEQKRQNLLRSELAWIRRGAKARTTKQKARIERFEKLKDQEMVHSSGELDVSVASTRLGRKILEIEGLRMKIDDKTLIQDLSYIAVPEDRIGIVGPNGSGKSTLLNLIAGRIQPGGGEVVLGPTVKLGYFTQEHQEMDGSQRVIEYIKDEAEVVRTADGSAITAAQMLERFLFPPALQWTPIAKLSGGEKRRLYLLRVLMSAPNVLLLDEPTNDLDIQTLSVLEQYLDEFPGVCIVVSHDRFFLDRTVDKIMAFEGDGQIRVHVGSYSEYAEWMQRHGGEASGSKAEASIAKSASGSSDGTDSDSAKEAPRERLKFSYKEQREFDQIDGLIEDTESKLASIQSEMETAGSDAARLQELMKAQEETERELEHLMERWTYLNELAEKIEQSKKS 85.65 gnl|BL_ORD_ID|2238|hsp_num:0 2522 Z1_00363 Inner membrane ABC transporter ATP-binding protein YddA Loose 1100 67.0 oleB 33.96 3003036 protein homolog model n/a n/a macrolide antibiotic antibiotic target protection Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins MKTIKQFFYLVSPFWGRRAALYCWFLLILSLTLTLSSVWFNVKMNEWNGSFYNALQQLDGQALYKLLQQFVIIIAGLITVVVMGDFLRQKMIIRWREGMTEQVLERWLSKNSKHYMLRLTSQEPDNPDQRIAEDIRLLIESTMRLTVTFLHSLLTLISFATILWSLSGALSFSLAGKEWNIPGYMFWACIIYTLIGITITQLIGSPLRKINMDKQRKEADYRTALITRKQHGDAIAGQRGEMSDRHELMGRFLGVIRNWNNLIRYERNLAFFTVGYQQATAMAPIIFALPKFLAGELMLGGLMQLRQAFSSVAGALSWFIFSYKEIAAWQATVTRLYHFVVLLEHDHQPEITELDDKQTKLTANLSLFMQDDRLLINNIHFSLKAGELAVIEGSSGIGKSTLLRALSGHWPYFKGDIQRVTNISWLPQRMYLPVARLDNLLAYPCQASQFSQQEYQEVLHWVGLDKIKNQLSLETDWTTRLSGGEQQRLIFARLLLNKPDLILLDETTSALDEQNALHMLLLLKQHLPTSGIVLVSHQRFTHAIAEQVISLQAPTASSSQSAGVTEYVS MQNAHRSDTGAAALTGTPEKLLPTQPETGSFQVVLDDVVRAPGGRPLLDGVNQSVALGERVGIIGENGSGKSTLLRMLAGVDRPDGGQVLVRAPGGCGYLPQTPDLPPEDTVQDAIDHALAELRSLERGLREAEQALAGAEPEELEGLLGAYGDLLEAFEARDGYAADARVDAAMHGLGLAGITGDRRLGSLSGGEQARLNLACLLAASPQLMLLDEPTNHLDVGALEWLEERLRAHRGSVLVVSHDRVFLERVATALWEVDGERRTVNRHGGGYAGYLQAKAAARRRWEQAYQDWLEDLARQRELARSAADHLATGPRRNTERSNQRHQRNVEKQISARVRNAKERVRRLEENPVPRPPQPMRFRARVEGGGTVGRGGALAELYKVTVGTRLDVPSFTVDPGERILITGHNGAGKSTLLRVLAGDLAPDQGECERPERIGWLPQETEITDRQQSLLAAFAAGLPGIAEEHRGALLGFGLFRPSALGTAVGDLSTGQLRRLALARLLRDPADLLLLDEPTNHLSPALVEDLEEALAHYRGALVVVSHDRMFAQRFTGRRMHMEGGRFVE 100.00 gnl|BL_ORD_ID|1275|hsp_num:0 1388 Z1_00388 Urease operon transcriptional activator Loose 470 77.0 gadW 27.54 3003838 protein homolog model n/a n/a macrolide antibiotic; fluoroquinolone antibiotic; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MIAMVYGAKGEICINGQTITVTTNLTLIIPKYSQVSCDVTNFFPTKPIELHTLVLSETELQSVFSLLKPLIKSGAPITRHLPDYHLSTPEVVKTNFTLLQQCLPLEHGTPSQETLFMQQSLFFILLAVYHEGVDILNIFRFNYDEPKNQAITHLITQDPQRKWHLEDVAKTLYTTPSTLRRHLSKEGVSFCQLLLDVRMGIALNYLTFSNYSVFQISHRCGFGSNAYFCDAFKRKYGMTPSQFRTQSRQANDPNAIATMASQNDESIKKVF MAHVCSVILVRRSFDIHHEQQKISLHNESILLLDKNLADDFAFCSLDTRRLDIEELTVCHYLQNIRQLPRNLGLHSKDRLLINQSPPIQLVTAIFDSFNDPRVNSPILSKMLYLSCLSMFSHKKELIPLLFNSISTVSGKVERLISFDIAKRWYLRDIAERMYTSESLIKKKLQDENTCFSKILLASRMSMARRLLELRQIPLHTIAEKCGYSSTSYFINTFRQYYGVTPHQFSQHSPGTFS 111.98 gnl|BL_ORD_ID|2087|hsp_num:0 2324 Z1_00391 Aerobic respiration control sensor protein ArcB Loose 2300 204.9 evgS 27.9 3000833 protein homolog model n/a n/a macrolide antibiotic; fluoroquinolone antibiotic; penam; tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump MKLLKGLAQYYVDLMMRLGLIRFSLLLASALVVLAMVVQMAVTFLLAGDVTSIDLVRSIFFGLIITPWAVYFLSVVVEQLEESRRRLSRMVDKLGVMRQRDLELNSQLKENIEQLNLEIQEREKVEKAHLELLEKLKSEMKRRELTQIELEQQSSLLRSFLDASPDLVYYRNEDNEFSGCNRATELLTGKSEKQLIGLTPLDVYDEDIAVKVMETDEKVFRHNVSLTYEQWLVYPDGRKACFELRKVPFYDRIGKRHGLMGFGRDITERKRYQDALENASRDKTTFISTISHELRTPLNGIVGLSRILLDTELSPEQLNYLKTIHVSAITLGNIFNDVIEMDKIERRKIQLDNQPIDFTEFISDLENLSGLLVQPKGLKFTLEAQETLPHKITTDGTRLRQILWNLIGNAVKFTQEGEIKVRIWQEAPDKLFFEVKDSGIGIPQGELEKIFAMYYQVNDSQGGRSATGTGIGLAVSKRLAQHMGGDIHVESELGHGSIFTLSIVAPAIKEQSDFEEDDELLLPALNILLVEDIELNVIVACSVLEKLGNTVDVAMTGQEALQMFKPGEYDLVLLDIQLPDMTGFDISRKLRQEFDSSELPPLIALTANVLKDKKEYLDAGMNDVLSKPLSVDALTAIINKFWGDEAVSVTSSESPQLLSKNEELLDIDMLNQYIELVGPQLITDGLDVFEKMMPSYLSVLESNLTARDQKGITEEGHKIKGAAGSIGLKHLQQLAKQIQSPELPAWWDNVQEWVDELERDWRKDVESLRNWLADARKK MKFLPYIFLLCCGLWSTISFADEDYIEYRGISSNNRVTLDPLRLSNKELRWLASKKNLVIAVHKSQTATLLHTDSQQRVRGINADYLNLLKRALNIKLTLREYADHQKAMDALAEGEVDIVLSHLVTSPPLNNDIAATKPLIITFPALVTTLHDSMRPLTSPKPVNIARVANYPPDEVIHQSFPKATIISFTNLYQALASVSAGHNDYFIGSNIITSSMISRYFTHSLNVVKYYNSPRQYNFFLTRKESVILNEVLNRFVDALTNEVRYEVSQNWLDTGNLAFLNKPLELTEHEKQWIKQHPNLKVLENPYSPPYSMTDENGSVRGVMGDILNIITLQTGLNFSPITVSHNIHAGTQLSPGGWDIIPGAIYSEDRENNVLFAEAFITTPYVFVMQKAPDSEQTLKKGMKVAIPYYYELHSQLKEMYPEVEWIQVDNASAAFHKVKEGELDALVATQLNSRYMIDHYYPNELYHFLIPGVPNASLSFAFPRGEPELKDIINKALNAIPPSEVLRLTEKWIKMPNVTIDTWDLYSEQFYIVTTLSVLLVGSSLLWGFYLLRSVRRRKVIQGDLENQISFRKALSDSLPNPTYVVNWQGNVISHNSAFEHYFTADYYKNAMLPLENSDSPFKDVFSNAHEVTAETKENRTIYTQVFEIDNGIEKRCINHWHTLCNLPASDNAVYICGWQDITETRDLINALEVEKNKAIKATVAKSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALSCSSTFPEHYLVKIDPQAFKQVLSNLLSNALKFTTEGAVKITTSLGHIDDNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPVEISQQVATVEAKAEQPITLPEKLSILIADDHPTNRLLLKRQLNLLGYDVDEATDGVQALHKVSMQHYDLLITDVNMPNMDGFELTRKLREQNSSLPIWGLTANAQANEREKGLSCGMNLCLFKPLTLDVLKTHLSQLHQVAHIAPQYRHLDIEALKNNTANDLQLMQEILMTFQHETHKDLPAAFQALEAGDNRTFHQCIHRIHGAANILNLQKLINISHQLEITPVSDDSKPEILQLLNSVKEHIAELDQEIAVFCQKND 65.00 gnl|BL_ORD_ID|1217|hsp_num:0 1318 Z1_00396 hypothetical protein Loose 290 57.0 golS 27.88 3000504 protein homolog model n/a n/a monobactam; carbapenem; cephalosporin; cephamycin; penam; phenicol antibiotic; penem antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MLFQVGEIAKKTGLTVRTLHHYEEIGLLQPTARTDAGYRLYDMKSIERLTQIQMLRQIGVKLKDIGHILNGHSAEIACLIEERISQLTTQMQQIAKLRYQLEHVQQQIQTGTPFTQHDWFSLLEMMSMYDKYFTYSELAQLPLYTAHTLKSQAWQQRISIVNNLIKQGKSADSNEAMQVSREWMIALEQDTGGNPDFFVRLNKMHIADDKFATATGITKQMIDFVAKGFNEYQLSVFKPHLTPEQFAVVHQHYFDAGSVWPELISGLYNALTCGEKADSEQVQNLAKMWLNMFNQFTQGDSDIQAKIRTIYQTDHEIAKGTWMTPEIGQYLFTAISFLVQK MNIGKAAKASKVSAKMIRYYEQIGLIPAASRTDSGYRAYTQADVNQLHFIRRARDLGFSVAEISDLLNLWNNQSRQSADVKRLAQTHIDELDRRIQNMQHMAQTLKALIHCCAGDALPDCPILHTLGQPDDSEPEARTGAVLRRPRRHGLAKRL 221.43 gnl|BL_ORD_ID|36|hsp_num:0 44 Z1_00408 UDP-N-acetylglucosamine 1-carboxyvinyltransferase Loose 800 394.0 Staphylococcus aureus murA with mutation conferring resistance to fosfomycin 49.88 3003776 protein variant model D278E D116C:2286 phosphonic acid antibiotic antibiotic target alteration antibiotic-resistant murA transferase MDKFRVQGPTCLSGEVTISGAKNAALPILFAAILAEEPVELTNVPKLKDIDTTIKLLNRLGTKVERNGSVFVDARHINEFCAPYELVKTMRASIWALGPLVARFGRGQVSLPGGCAIGARPVDLHITGLEQLGAEITLDEGYVKARVDGRLKGAHIVMDKVSVGATITIMTAAVLAEGKTIIENAAREPEIEDTANFLNTLGAKISGAGTDSITIEGVERLGGGTYQILPDRIETGTFLVAAAVSRGRVVCRNAKPDTLDAVLAKLREAGADIETGEDWISLDMHGKRPKAVTLRTAPHPGFPTDMQAQFSLLNLVADGAGMITETIFENRFMHIPELIRMGAHAEIESNTVLCHGVDKLSGAQVMATDLRASASLVLAGCIAEGTTIVDRIYHIDRGYENIEAKLQGLGAKIERLHSND MDKIVIKGGNKLTGEVKVEGAKNAVLPILTASLLASDKPSKLVNVPALSDVETINNVLTTLNADVTYKKDENAVVVDATKTLNEEAPYEYVSKMRASILVMGPLLARLGHAIVALPGGCAIGSRPIEQHIKGFEALGAEIHLENGNIYANAKDGLKGTSIHLDFPSVGATQNIIMAASLAKGKTLIENAAKEPEIVDLANYINEMGGRITGAGTDTITINGVESLHGVEHAIIPDRIEAGTLLIAGAITRGDIFVRGAIKEHMASLVYKLEEMGVELEYQEDGIRVRAEGDLQPVDIKTLPHPGFPTDMQSQMMALLLTANGHKVVTETVFENRFMHVAEFKRMNANINVEGRSAKLEGKSQLQGAQVKATDLRAAAALILAGLVADGKTSVTELTHLDRGYVDLHGKLKQLGADIERIND 99.76 gnl|BL_ORD_ID|2076|hsp_num:0 2285 Z1_00413 Intermembrane phospholipid transport system permease protein MlaE Loose 450 93.6 RanB 29.54 3005090 protein homolog model n/a n/a aminoglycoside antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MVNLLARLGARSLSIFATFGRAGIMLFRALIGKPEFRKQWPLLMKQLYSVGVQSLLIIMVSGLFIGMVLGLQGYLVLTTFSAEASLGMMVALSLLRELGPVVTALLFAGRAGSALTAEIGLMKATEQISSLEMMAVDPLRRVVAPRFWAGFISMPLLSLIFVAVGIWGGAIVGVDWKGIDEGFFWASMQGAVEWQKDLVNCFIKSVVFAITVTWIALFNGYDAIPTSEGISRATTRTVVHSSLAVLGLDFVLTALMFGN MLKLSKRMLTSVGEYVLLLGKVIKRPQKHNIFFKLLMREINDLGVNSFGLVLFTSIFVGAVVAIQMYNNFKASTIPIPLYFIGYATKVVLILEFSPTIISLILAGKVGSYIASSIGTMRVTEQIDALDIMGVNSPNFLILPKIVANVIFNPLLIAISIVFGIYGGYLAGVATGNWTEADYITGIQRYIPDYFIWYAFFKTVVFAFLIATIPAYFGYNVKGGSLEVGRASTQAVVWTMVAIIIAELISTQLFLS 102.37 gnl|BL_ORD_ID|2816|hsp_num:0 3824 Z1_00414 Intermembrane phospholipid transport system ATP-binding protein MlaF Loose 500 131.3 RanA 34.35 3005091 protein homolog model n/a n/a aminoglycoside antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MNAQPDNLIEVRNMNFTRGSRKIFSQINLDVPRGKVTAIMGPSGIGKTTLLRLMGGQILPDSGDIWFDGDNIPKLSRSALYQSRKKMSMLFQSGALFTDMNVFENVAFPLREHTNLPEALIHTTVMMKLEAVGLRGAANLMPSELSGGMARRAALARAIALDPDLIMFDEPFVGQDPITMGVLVKLIDELNHALGVTCVVVSHDVPEVLSIADYAYIIAEQKIIAQGSAKELQENPDRQVRQFLDGIADGPVPFRFPAGNYQDDLLGRGN MIEVKDLRKSFNDVEVLKGITTTFETGKINLVIGQSGSGKTVFLKCLLNVFDPSSGDILFDGRNLSIMGRTEKQEIRSEIGTVFQGSALFDSMTVEENISFPLDMFTNLTYTEKRKRVKEVIGRVHLENANTKFPSEISGGMQKRVAIARAIVNNPKYLFCDEPNSGLDPNTAIVIDELIKEITEEYNTTTIINTHDMNSVLTIGEKIVYLRKGVKEWEGNKDLIIKAENEHLIDFVYSSALFKQVRETMLRNNQTNL 104.65 gnl|BL_ORD_ID|2817|hsp_num:0 3825 Z1_00420 Lipopolysaccharide export system ATP-binding protein LptB Loose 650 128.3 tetA(58) 35.75 3003980 protein homolog model n/a n/a tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MALLKAENLAKAYKGRTVVGDVSLNVNSGEIVGLLGPNGAGKTTTFYMVVGIVARDAGSITIDDEDITLLPLHERARKGIGYLPQEASIFRRLSVYDNIMGILEIRHDLTAEQRKDRAEELLEEFNVSHLRNSLGQSLSGGERRRVEIARALAANPKFILLDEPFAGVDPISVLDIKKIIQHLRDYGLGVLITDHNVRETLDVCERAYIVSQGHLIAHGSPEEILANEQVKRVYLGEGFRL MEHAYKKKIEPKPGDLAVEAYGLIKTFGDNRAVDGVDLNVRTGTIYGVLGPNGAGKTTTIRMLATLLRPDAGSARIFGHDVQAESQIVRQLIGVTGQYASVDESLSATENLIIFSRLLGLGRKEARRKAEELLEEFGLSEAAKRPLKNFSGGMRRRLDLAASLIAQPPLIFLDEPTTGLDPRTRSQMWDTIRRLVNTGSTVLLTTQYLEEADQLADRIAVIDYGRVVAEGTADELKMSVGTSSLHLTVEDSVDMDRACHTVEQVLGVHANVSPEAGKITAPMANAGLVTDLLIELRTAGIGLSEMSVQKPTLDEVFLTITGHGVKEDAAQESYESNDREVARV 70.26 gnl|BL_ORD_ID|2251|hsp_num:0 2517 Z1_00442 Biotin carboxylase Loose 275 43.5 vanE 21.97 3002907 protein homolog model n/a n/a glycopeptide antibiotic antibiotic target alteration glycopeptide resistance gene cluster; Van ligase MLEKILIANRGEIALRILRACKELGIKAVAVHSTADRDLKHVLLADETICIGPAASAKSYLNIPAIIAAAEISGAQAIHPGYGFLSENADFAEQVERSGFIFIGPKAETIRLMGDKVSAIEAMKKAGVPCVPGSDGPLGNDTAKNIEIAKRIGYPVIIKASGGGGGRGMRVVRSEKDLAQAISMTRAEAKAAFSNDMVYMEKYLENPRHVEIQVMADGQGNAIYLAERDCSMQRRHQKVVEEAPAPGITPEIRKNIGERCANACIEIGYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVTEMITGVDLIKEQLRIASGLPLSVTQDQIHVHGHAIECRINAEDPKTFLPSPGTITRFHSPGGFGVRWESHIYAGYTVPPHYDSMIGKLITYGETREIAISRMKNALAELIIDGIKTNIELHQFIMNDEQFQKGGTNIHYLEKRLGLTEN MKTVAIIFGGVSSEYEVSLKSAVAIIKNMESIDYNVMKIGITEEGHWYLFEGTTDKIKKDRWFLDESCEEIVVDFAKKSFVLKNSKKIIKPDILFPVLHGGYGENGAMQGVFELLDIPYVGCGIGAAAISMNKIMLHQFAEAIGVKSTPSMIIEKGQDLQKVDAFAKIHGFPLYIKPNEAGSSKGISKVERKSDLYKAIDEASKYDSRILIQKEVKGVEIGCGILGNEQLVVGECDQISLVDGFFDYEEKYNLVTAEILLPAKLSIDKKEDIQMKAKKLYRLLGCKGLARIDFFLTDDGEILLNEINTMPGFTEHSRFPMMMNEIGMDYKEIIENLLVLAVENHEKKLSTID 127.56 gnl|BL_ORD_ID|1481|hsp_num:0 1617 Z1_00457 sn-glycerol-3-phosphate import ATP-binding protein UgpC Loose 500 105.1 RanA 28.96 3005091 protein homolog model n/a n/a aminoglycoside antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MTTVTLTNLEKRYPNGYQAISTLNLSIEQGEMVVLVGPSGCGKSTLLRMIAGLETITDGDLLIDNRRVNEHEPSERDIAMVFQNYALYPHMSVYDNMAYGLRNRKVPKAEIIARVDRAAHMLEISHLLDRKPKELSGGQRQRVAMGRAIVRDPKVFLFDEPLSNLDAKLRVQMRLEIKKLQQKLATTSVYVTHDQVEAMTLADKLVVLNQGHIEQVGSPLEIYESPASVFVATFMGSPAMNILTTHINRGIIEIADGHLAISAHSLPNGEIQLGLRPEHLLINQQNPLFHANVDFIEALGADVLIYATTCDQQSIVIRAANDHGVNVGNRIGVAIYPENLHFFDRQTQKRIERPTMLLSERLVS MIEVKDLRKSFNDVEVLKGITTTFETGKINLVIGQSGSGKTVFLKCLLNVFDPSSGDILFDGRNLSIMGRTEKQEIRSEIGTVFQGSALFDSMTVEENISFPLDMFTNLTYTEKRKRVKEVIGRVHLENANTKFPSEISGGMQKRVAIARAIVNNPKYLFCDEPNSGLDPNTAIVIDELIKEITEEYNTTTIINTHDMNSVLTIGEKIVYLRKGVKEWEGNKDLIIKAENEHLIDFVYSSALFKQVRETMLRNNQTNL 141.09 gnl|BL_ORD_ID|2817|hsp_num:0 3825 Z1_00460 Multidrug resistance protein MdtL Loose 500 92.8 bcr-1 26.36 3003801 protein homolog model n/a n/a bicyclomycin-like antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MKLSIRSLFYLVCFSALLGSLAQNIYTPVLPLIQQQFNTTLSLVNLTVSAFTFAMAVMQLCYGSLIDKWGRKPILLSGLTISIIGALICIWANSINLLIFGRVIQAIGIAAIPVVAATILGDLYQGNERAKAMGSYQMLLALAPASGPLLGGYLAQNYHYQSIFVFLSMVGLVLLIAHLFYLPETRPEQKQSVKSLSAMRQVLAAPEGKSVFVISFMVFYNYFCLLVFLPLIAFHLYHLNSSEIGGLYVPMSIALVLGSYLYRKVCHLFSAEYGVIITSCINLAMLSLFALFWQISLPIMLILTVLYGLSLGLTMPTHTTLLTSHFSSVRATAMGIYNFIRYCGMAAGPMVASYFVTDNHYQYVFYSCVILTSLALCFAIKTLLSTLKQQRQTID MPASASRIQVGSGERRLLLLLSALVAFGPLSIDMYLPSLPAIAADLGASDAQVQRSISGFLVGFCVGMLFYGPLSDRFGRRPVLLAGIALYLFSSLACALADSAGQLVLLRVLQALGGGAASVLARAMVRDLYPLGEAARMLALMHMVTMLAPLAAPLLGGYLMLWAGWRALFVVLALFAGLCLLAVWRVAESHPPERRGGSLAQAFLAYGRLLGDRRALGYVLCMGLAFAGMFAYISAAPFVFIEHFGVRAERFGWFFGLNILGVMLATWCSARLVRRHGPRPLLRAGSLLACVSGLFLLGYAALGERGGLWALVPGLLCFVSVTGLLGANCIASLLALYPGQAGAASAVAVSGQFGLGCLASLAVGWLALPGVLPMALVMAVCGVGSLLALGLALHGGNR 98.26 gnl|BL_ORD_ID|2340|hsp_num:0 2303 Z1_00465 Cell division ATP-binding protein FtsE Loose 1280 134.0 macB 34.0 3000535 protein homolog model n/a n/a macrolide antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MIRFEHVSKAYLGGRQALQGVDFHLRPGEMAFLTGHSGAGKSTLLKLICGIERPSDGAIWFAGHDISRLKNSEIPFLRRQIGMIFQDHHLLMDRTVYDNVSLPLIIAGASEEDIRRRVSAALDKVGLLDKAKNYPIQLSGGEQQRVGIARAVVNKPTVLLADEPTGNLDGELSEGIMRLFEEFNRVGVTVLMATHDMTLVERRNYRILTLGQGRMVGGQNG MSLIECKNINRYFGSGENRVHILKDISLSIEKGDFVAIIGQSGSGKSTLMNILGCLDTAGSGSYRIDGIETAKMQPDELAALRRERFGFIFQRYNLLSSLTARDNVALPAVYMGMGGKERSARADKLLQDLGLASKEGNKPGELSGGQQQRVSIARALMNGGEIIFADEPTGALDTASGKNVMEIIRRLHEAGHTVIMVTHDPGIAANANRVIEIRDGEIISDTSKNPEIPASNVGRIQEKASWSFYYDQFVEAFRMSVQAVLAHKMRSLLTMLGIIIGIASVVSVVALGNGSQKKILEDISSMGTNTISIFPGRGFGDRRSGKIKTLTIDDAKIIAKQSYVASATPMTSSGGTLTYRNTDLTASLYGVGEQYFDVRGLKLETGRLFDENDVKEDAQVVVIDQNVKDKLFADSDPLGKTILFRKRPLTVIGVMKKDENAFGNSDVLMLWSPYTTVMHQITGESHTNSITVKIKDNANTRVAEKGLAELLKARHGTEDFFMNNSDSIRQMVESTTGTMKLLISSIALISLVVGGIGVMNIMLVSVTERTKEIGIRMAIGARRGNILQQFLIEAVLICIIGGLVGVGLSAAVSLVFNHFVTDFPMDISAASVIGAVACSTGIGIAFGFMPANKAAKLNPIDALAQD 34.32 gnl|BL_ORD_ID|447|hsp_num:0 487 Z1_00472 Toluene efflux pump membrane transporter TtgH Loose 1950 1231.1 MexB 60.86 3000378 protein homolog model n/a n/a macrolide antibiotic; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; cephamycin; penam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; penem antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MSRFFINRPILSWVMAIVIMIAGGLSLIKLPVSQYPEIAAPAIMITAVYPGASAETVQDTVVQVIEQELSGLDGFRYLSSNSNTDGSFEVIATFEQGTDSDIALMQVQNKLQLATPKLPLEVQRQGMRVVKFQINFMQVVALVDESGKLDAFDLGNYLASHMKDPISRIDGMGDILLLGSPRAMRIWLDPDKLTNYHLMPKDIAAAIQDENVQVSAGQLAGLPALKGVELNATITSSSRMVSVDEFNHILLKVNLDGSQVLLQDVAKVEVGADNFSISSLYNGKPSAGMAMRLAPGANLLDVSKKVKEVVEAQSQFFPQGVKALFPYDTTPSVKSSISSVVRTIVEASILVFLVMFLFLQNIRATLVPTLAIPVVLLGTFGVLAALGLTINVLTMYAMVLAIGLLVDDAIVVVENVERIMHEQAISVKEATILSMTQIQGALVGIGLVLSAVFVPMAFFGGSAGIIYRQFAATIVVAMALSVLIALTFTPALCASILKKPQPKVKKRRGFFWLFNRFFDRGTNYYEKGVRNILYRRGRYMFIFLIITVGTGWLFTQLPKAFLPNEDQGVVMIEVRMPANSTAERMEQTMAEFRDYLLTEEKHLVKTVFTVNGFNFAGRGQNAGMAFVNLADWSERKGKGEDVFSLVARAQQHFNSIRDGMVIAFPPPAIMEMGNAMGFDFYLQDNAGLGHTELVKARDKFLELAAQSPVLTNVRPNGKNDEPQLRVVIDKERARALQLRLSDINDTLSAAWGSMYVNDFIDEGRVKRVYLQGEASARMLPTDLDKWHVRNQRGEMIPFNAFATTQWYMGPPKLERFNGLSAIEILGEPAPGYSTGDAMLAIADIMKQLPSEISLSYSGLSYEEIQTQDQAPALYVMTILFVFLSLAALYESWSVPFSVALVVPFGILGAVIATLLRGLSSDVYFQIGLMTTIGLSAKNAILIVEFAKHLYEKDGKPLIDAAAEAARMRLRPIIMTSLAFTFGVLPMALASGAGQGSQHSVATGVIGGMLASTFLAIFFVPLFYVFVVKLFSRKKAHVSIEEIDK MSKFFIDRPIFAWVIALVIMLAGGLSILSLPVNQYPAIAPPAIAVQVSYPGASAETVQDTVVQVIEQQMNGIDNLRYISSESNSDGSMTTTVTFEQGTDPDIAQVQVQNKLQLATPLLPQEVQRQGIRVTKAVKNFLMVVGVVSTDGSMTKEDLSNYIVSNIQDPLSRTKGVGDFQVFGSQYSMRIWLDPAKLNSYQLTPGDVSSAIQAQNVQISSGQLGGLPAVKGQQLNATIIGKTRLQTAEQFENILLKVNPDGSQVRLKDVADVGLGGQDYSINAQFNGSPASGIAIKLATGANALDTAKAIRQTIANLEPFMPQGMKVVYPYDTTPVVSASIHEVVKTLGEAILLVFLVMYLFLQNFRATLIPTIAVPVVLLGTFGVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVMAEEGLSPREAARKSMGQIQGALVGIAMVLSAVFLPMAFFGGSTGVIYRQFSITIVSAMALSVIVALILTPALCATMLKPIEKGDHGEHKGGFFGWFNRMFLSTTHGYERGVASILKHRAPYLLIYVVIVAGMIWMFTRIPTAFLPDEDQGVLFAQVQTPPGSSAERTQVVVDSMREYLLEKESSSVSSVFTVTGFNFAGRGQSSGMAFIMLKPWEERPGGENSVFELAKRAQMHFFSFKDAMVFAFAPPSVLELGNATGFDLFLQDQAGVGHEVLLQARNKFLMLAAQNPALQRVRPNGMSDEPQYKLEIDDEKASALGVSLADINSTVSIAWGSSYVNDFIDRGRVKRVYLQGRPDARMNPDDLSKWYVRNDKGEMVPFNAFATGKWEYGSPKLERYNGVPAMEILGEPAPGLSSGDAMAAVEEIVKQLPKGVGYSWTGLSYEERLSGSQAPALYALSLLVVFLCLAALYESWSIPFSVMLVVPLGVIGALLATSMRGLSNDVFFQVGLLTTIGLSAKNAILIVEFAKELHEQGKGIVEAAIEACRMRLRPIVMTSLAFILGVVPLAISTGAGSGSQHAIGTGVIGGMVTATVLAIFWVPLFYVAVSTLFKDEASKQQASVEKGQ 99.81 gnl|BL_ORD_ID|1792|hsp_num:0 1925 Z1_00473 Solvent efflux pump periplasmic linker SrpA Loose 650 318.2 MexA 45.9 3000377 protein homolog model n/a n/a macrolide antibiotic; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; cephamycin; penam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; penem antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MKKTKHLFKTKGCNIPFTSVMMVSFVLMGCNDQSTQPTKPAIPEVGVYTVKEEILPLTVDLPARTASYRVSQVRPQVDGILEKRLFTEGSDVKKDQPLYQIDKKPYETQVAKAQAAYDNVKKLAARYKSLRATNAISQQEYDDVVSRLDQAKADLNQAKINLGYTQVLSPISGKISRSFVSEGALVSSGQNQPLATITQLDPIYVDITQPITNQLKLKSLIQQGVVTDSEDKMDVTLFLEDGSQYPYTGTLSFSEVQVEPSTGSVTLRAKFPNPQHQLLPGMYTKARIMQGTQEKAIVVPQQAITFDARGKSITYIVDQQQVLQARDVEILKPQGNGWIIKQGLQAGDRIMTEGHHRAKPGVKVNAVPANNISLKTTLE MQRTPAMRVLVPALLVAISALSGCGKSEAPPPAQTPEVGIVTLEAQTVTLNTELPGRTNAFRIAEVRPQVNGIILKRLFKEGSDVKAGQQLYQIDPATYEADYQSAQANLASTQEQAQRYKLLVADQAVSKQQYADANAAYLQSKAAVEQARINLRYTKVLSPISGRIGRSAVTEGALVTNGQANAMATVQQLDPIYVDVTQPSTALLRLRRELASGQLERAGDNAAKVSLKLEDGSQYPLEGRLEFSEVSVDEGTGSVTIRAVFPNPNNELLPGMFVHAQLQEGVKQKAILAPQQGVTRDLKGQATALVVNAQNKVELRVIKADRVIGDKWLVTEGLNAGDKIITEGLQFVQPGVEVKTVPAKNVASAQKADAAPAKTDSKG 98.96 gnl|BL_ORD_ID|439|hsp_num:0 440 Z1_00489 Guanidinium exporter Loose 180 69.3 qacL 35.92 3005098 protein homolog model n/a n/a disinfecting agents and antiseptics antibiotic efflux small multidrug resistance (SMR) antibiotic efflux pump MSWIILFVAGLLEIVWAVGLKYTHGFTRLTPSIITISAMIVSMGMLSYAMKGLPAGTAYAIWTGIGAVGTAIFGIIVFGESANIYRLLSLAMIVFGIIGLKLAS MKNWIFMAVAIFGEVIATSALKSSHGFTRLVPSVVVVAGYGLAFYFLSLALKSIPVGIAYAVWAGLGIVLVAAIAWIFHGQKLDFWAFIGMGLIVSGVAVLNLLSKVSAH 94.55 gnl|BL_ORD_ID|2823|hsp_num:0 3830 Z1_00493 DNA-binding transcriptional activator HyfR Loose 400 221.5 TxR 38.12 3005008 protein homolog model n/a n/a tetracycline antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MKLSSNNAETMESLRSERNQYRILVDITNSVLAHLDMDGLISEVSKEIHRFFGLNHISLMLCRTSSQNSHEGILYSSRYQTGKSVIRQQRKFSSANNKAEEIIHQNKPVLIDINKEDQDDVLIKRLVKQNMQTALLLPLAFNRKPLGLLILAHEISSVFTEETCQLLQQIAARIGIAIENAAAYEEITHLKDSLKNENIWLNEQINRNGSFSEIIYQSDAMHNVLEQIELVAQSDSTVLILGETGTGKELIARAIHRLSHRKNKTMIKMNCAAVPSGLLESDLFGHDKGAFTGATHAHVGRFEMADKSTLFLDEIGDMPIELQPKLLRVLQEREIERLGGNKVIPVDVRLIAATNKDLCELTDEGEFREDLYYRLNVFPIIIPPLRERPEDIPLLAKYFTQKIARRMDRKIDCIPTHALEQLTHYPWPGNVRELENIIERAVILTRGSTLNLQLKELNINKPSRLKQVLSQPSAIEKKMQTSAPESDDEERERIIQALRETNGVVAGARGAALKLGLKRTTLLSRMQRLGISIPEIL MKVQKCKATIHRRSLDADPLLPLIGNSTCISELRNKLKKYAQCDAEVLIQGETGVGKGMCARIIHELSSRHIYPFVEVNCGAIPSGLIASELFGHEKGAFTGAISDRIGFIQKANKGTLFLDEIGDMPPDLQIHLLHFLESKQIHKVGADKIIDVDCRVIAASHVDLKSEVIQGGFREDLFYRQNILPLTIPPLRKRGEDTVILSERFLEELSNGKVQSMSPEVKKKLLKHKWPGNVRELRNVIQRAIVMCEDNTLHIADLGLDNNERQLLPSVEQIDLDYLLKAIEDNKHNMSAAARNLGISRTTLYRLIKKYNLPI 168.87 gnl|BL_ORD_ID|4730|hsp_num:0 3753 Z1_00497 Kdo(2)-lipid A phosphoethanolamine 7''-transferase Loose 1000 529.3 eptB 47.56 3005047 protein homolog model n/a n/a peptide antibiotic antibiotic target alteration pmr phosphoethanolamine transferase MQKLKFLRFSKEKVSLFLAVYIGLFLNLSVYIGRYGTQNSHNSLIESLYILGEVAVNIAFTFFLLRLISFCGTLFFKIVASFILLISVCASYYISFFDVVIGYGIIISTLTTDIDLSKELISPNVIIWIIGLSILPLALTWLCKKPEKNITQQQKKKIWIKNTVKMLVIALAVFAYLKTLDSKQKAYEIKNNLDLPSYSGGLSYAYLPTNWIIPLFQYAITQYDDHFNSQNIFDPADNFTYIPSKANEDVYVVFIIGETARWDHMGLFGYERQTNPLLSQEKNLIALKGISCDTATKLSLKCMFVRENGTENNDQRTLKENNIFSVLHQLGMTSELFSMQSELWFYNKLDLDNYAMKEMMTAKNSNFGKELDDTLLINEVADSVAHYSKGNHLVILHTKGSHFMYSQRYPNAFKKYQPECLNVDDECTKEQLINAYDNSILYTDYFIDGVLNTLRDKKAIVFYTSDHGESISEKGGLHGTPKEIAPPEQFKVPFLVWMSDSYLAEPENKQLFDNLKRNQDNNRTFYHHNIFDSILGCLGYSSPDGGINNQNNLCFGDIASEAH MPQRQAVFYSSFSRFACMKYIRTMTQQKLSFWLALYIGWFMNVAVFFRRFDGYAQEFTFWKGLSGVVELVATVFVTFFLLRLLSLFGRRIWRILATLIVLFSAAASYYMTFLNVVIGYGIIASVMTTDIDLSKEVIGWHLILWLVVVSAPPLLFIWSNRCRHTLLRQLRTPGQRVKNVLIVVLAGLIVWGPIRLLELRQHDVERHSEVDMPSYGGVIANSYLPSNWLSALGLYAWAQVDESSDNKSLINPAKKFTYVAPEGLDDTYVVFIIGETTRWDHMGILDYSRNTTPELEKEKNLVAFRGYLCDTATKLSLRCMFVREGGAEDNPQRTLKEQNVFAVLHQLGFSGNLYAMQSEMWFYSNTMANNIAYREQIGAEPRNRGKSVDDMLLVDEMKRGMAQGNASGKHLIILHTKGSHFNYTQRYPRSFAQWKPECVGVDNKCSKAELINSYDNSVTYVDHFIVSVLDQLRDKKAIVFYAADHGESINEREHLHGTPRKMAPPEQFRVPMMVWMSDKYLENPDHAAAFAHLQQQAAMKVPRRHVELYDTIMGCLGYTSPDGGINENNNWCRWKK 98.08 gnl|BL_ORD_ID|2787|hsp_num:0 3791 Z1_00505 Nitrate/nitrite response regulator protein NarL Loose 390 92.8 evgA 27.18 3000832 protein homolog model n/a n/a macrolide antibiotic; fluoroquinolone antibiotic; penam; tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump MNNMGAVADKATILLIDDHPMLRNGVKQLLSLDTTLTVVGEAGDGIQGVKLAEELDPDLILLDLNMPGMNGFETLDQLRLRSLSGRIVVFSVSNYSDDLITALKRGADGYLLKDMEPEELLAALKQAAAGKMVVSPTLTPILAQSLREDRSEGERDIDQLTPRERDILKLIAQGLSNKMIARKLDITESTVKVHVKHLLKKMKLKSRVEVAVWVHQQRVD MNAIIIDDHPLAIAAIRNLLIKNDIEILAELTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQVLETLRKRQYSGIIIIVSAKNDHFYGKHCADAGANGFVSKKEGMNNIIAAIEAAKNGYCYFPFSLNRFVGSLTSDQQKLDSLSKQEISVMRYILDGKDNNDIAEKMFISNKTVSTYKSRLMEKLECKSLMDLYTFAQRNKIG 107.84 gnl|BL_ORD_ID|939|hsp_num:0 1015 Z1_00510 Carbamoyl-phosphate synthase large chain Loose 350 47.8 vanM 23.76 3002911 protein homolog model n/a n/a glycopeptide antibiotic antibiotic target alteration glycopeptide resistance gene cluster; Van ligase MITTNQKQRVKHRVLIANRGEIAVRIIRACQDYGATSIAIYADDDIDALHVRLADEAYGLKGNSPKESYLAIDKIIEIAHKSKATMIHPGYGFLSERADFAKAVQQAGLLWIGPDPQTIEVLGDKVQARKIAQSVGAPLVNGTADPVSDAKEVLDFAKQYGLPIAIKAAFGGGGRGLKIAHHMAEIEELYHSAVREAVTAFGRGECYVEQFLDKPRHIEAQIIADKLGHVVVVGTRDCSLQRRNQKLIEEAPAPYLTDEQRQRIHQSAKDICAKAGYIGAGTVEFLLSANGTISFLEVNTRLQVEHPVTEETAGIDLVIEQLRIAEGLPLSINETPEPRGHSFEFRINAEDPAKGFLPTPGLISQFSQPAGPGVRVDSGVAENDQVSRQFDSMMAKLIVTGASREQAIARARRALAEFNIAGVASVLPFHREMMEHPDFIDNFSVHTRWIESDFQAKNSHFPRSIPAENEPLVRTFIEIDGRRHQLALPAQLLSLSAVIPTAISEHKECQVRENAVTAPISGILHSWLLSDGDKVNQGDVIAIMEAMKMEVQVVATCHGVLQQKAKAGDYFSADSLLAEIN MNRLKIAILFGGCSEEHNVSVKSAAEIANNIDIGKYEPIYIGITQSGVWKTCEKPCIDWDNEHCRSAVLSPDKKMHGLLIMQDKGYQIQRIDVVFSVLHGKSGEDGAIQGLFELSGIPYVGCDIQSSAVCMDKSLAYIIAKNAGIATPEFQVIYKDDKPAADSFTYPVFVKPARSGSSYGVNKVNSADELDSAIDLARQYDSKILIEQGVLGYEVGCAVLGNSFDLIVGEVDQIRLQHGIFRIHQEAEPEKGSENATITVPAELSAEERERIKEAAKNIYKALGCRGLSRVDMFLQDNGRIVLNEVNTMPGFTSYSRYPRMMVSAGITIPELIDHLIVLAVKE 169.39 gnl|BL_ORD_ID|1777|hsp_num:0 1924 Z1_00546 L-amino acid N-acetyltransferase AaaT Loose 275 42.7 AAC(6')-Isa 26.17 3002563 protein homolog model n/a n/a aminoglycoside antibiotic antibiotic inactivation AAC(6') MHQIEIRHGEPEDAIAIQQLYTHPDLYICTCQFPYPSVTMWKKRLIEFSEQNIPHFVASFDGQIAGHLALIIDNHPRRRHIVSFGIGVGAEFSGKGIGKALINTAIDYAFNWLAATRIELEVYADNERGLHLYKKLGFEVEGIRRNAAFREGKYCDVVMMAQLKSIE MELRGDDVVLRPVADGEGEVLDRIVREPEVAAWWSPPEDFAGMLAIVFEGEVVGAIQFYEETDPEFHHAGIDVFLTARHQGKGLGTDAVRTLARWLVAERGHHRLTIDPAAANTAAIRSYRKVGFRPVGIMRAYGRDHRTGRWQDALLMDLLADELT 106.37 gnl|BL_ORD_ID|889|hsp_num:0 967 Z1_00548 putative MFS-type transporter YcaD Loose 750 47.4 blt 22.88 3003006 protein homolog model n/a n/a fluoroquinolone antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MLQQNYRQSELFAITTITVSIAVIGIVIGLTIPMVALRLNLAGISESIIGLISAAPAMGMLIISPFARYIVQWLGKRLAMLLATIISAISLLPLMGSLPLEFLFPLRLITGIASGVMICLGETWINELVPDNKRGRILAIYTTVFTISQLLGPSIIALYGVADKTPILISVLLHIISIVLFLMMDQKVGDKLAKDSEESHFSILRFIKVAPAICGGIIFFAFFDGTVLSMFPIYGLSVGHSEAIAAMMISAILAGDAIMQMPFGWLADHMNRTRLYRICGVITLLASLLLPIAMPHTLVIWPLLLVLGATAGAIYTIALVQIGQYFSGNDLMIANASAAMLWGIGNLSGPILAGAMSEISPSALPFLLVVMTGLFLISTMDRFNLHVDTLNRHTS MKKSINEQKTIFIILLSNIFVAFLGIGLIIPVMPSFMKIMHLSGSTMGYLVAAFAISQLITSPFAGRWVDRFGRKKMIILGLLIFSLSELIFGLGTHVSIFYFSRILGGVSAAFIMPAVTAYVADITTLKERSKAMGYVSAAISTGFIIGPGAGGFIAGFGIRMPFFFASAIALIAAVTSVFILKESLSIEERHQLSSHTKESNFIKDLKRSIHPVYFIAFIIVFVMAFGLSAYETVFSLFSDHKFGFTPKDIAAIITISSIVAVVIQVLLFGKLVNKLGEKRMIQLCLITGAILAFVSTVMSGFLTVLLVTCFIFLAFDLLRPALTAHLSNMAGNQQGFVAGMNSTYTSLGNIFGPALGGILFDLNIHYPFLFAGFVMIVGLGLTMVWKEKKNDAAALN 98.75 gnl|BL_ORD_ID|1828|hsp_num:0 1975 Z1_00579 D-alanyl-D-alanine-carboxypeptidase/endopeptidase AmpH Loose 700 76.6 CSA-2 24.77 3006870 protein homolog model n/a n/a cephalosporin antibiotic inactivation CSA beta-lactamase MADLFCSLFFHLTRYVDHKMKKHLLKYLLIPVALLTLNACSQRATVTPTLPAKFNQHNVPELSQWPTTLSPKANNSREIFDKYAQQIYQKSNPQGMVIVMINNTQSLNRAFGTTSPDSRQTPSMNSLIRIASITKLMTSEVMLKLQDDGKLLVTDPLQKYSYYGVDIPLVNNQSPIRLYHLATHTSGFPREQPGGKWGRPVFIWPTHGDRWNWLKKASLTTPAGQSASYSNLAYDLLADALVKASGKNYPQLLKQYVTQPAGMRDTTLTPNSTQCQRLLIGYRPSPCSETIAAAGSGGVYSTPADMQRWMQGFLNSNNTMRKATASKEQSIYFPRQRLSSIEGMDVAGRADGIGLGWVYMAPANGVPAIYQKTGGGGGFNTYMATIPELNIGVFVVITRKANGTKFSEVTRGTNALVRALAQSF MKSKVSALLMMIVLAGHAQAAPVAPPDAVVKPLMARYQIPGMAVAVSVNGETHFWHYGVASKATRKPVDENTLFEIGSLSKTFTATLASKAQQDGKLDFSAPASQYLPALKGSAFDHVTLLNLATHTAGTPLFVPDAVKNTPQLMDWYRAWQPEKPVGTERVYSNLGIGLLGMITAKALDKPFSEAMEQGLLRDFGMTHTFINVPDAAMGDYAQGYNKDDKPVRVTPGPLDAESYGLKSGSADLLRYLQIQLGEQEVAPGWRQAINATHNGYYRSGEFTQGLMWEYYPWPSPLSRLVEGNSSQRIMKGLATTAIVPPQPAPQAAWYNKTGSTNGFSTYAVFIPEKRIALIMLANKWFPNDDRVKAAYAIIQELDK 113.07 gnl|BL_ORD_ID|3427|hsp_num:0 4486 Z1_00584 Valine--tRNA ligase Loose 2000 213.4 Staphylococcus aureus mupB conferring resistance to mupirocin 22.16 3000510 protein homolog model n/a n/a mupirocin-like antibiotic antibiotic target alteration antibiotic-resistant isoleucyl-tRNA synthetase (ileS) MENKSAPKEPSLDTTYNPTEIEQPLYQHWEKNGYFKANGDTSKESFCIVIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQAGTDHAGIATQMVVERKIAAEEGKNRHDYGRDAFIDKIWEWKAESGGNISNQMRRLGNSVDWDRERFTMDEGLSKAVKEAFVRLHKEDLIYRGKRLVNWDPKLHTAISDLEVENREVKGSMWHLRYPLADGVKTAEGKDYLIVATTRPETLLGDTGVAVNPEDPRYKDLIGKEVILPLMNRRIPILADEHADMEKGTGCVKITPAHDFNDYEVGRRHQLPMINIMDFDGNIRVSAEVLDTNGVESDVYSTEIPEAYQGMERFAARKAIVAEFERLGLLEEIKPHDLTVPYGDRGGVVIEPLLTDQWYVRAAPLAKPAVEAVKNGDIQFVPKQYENMYFSWMNDIQDWCISRQLWWGHRIPAWYDNEGHVYVGRDEEEVRRENNIAADVALRQDEDVLDTWFSSALWTFSTLGWPENTEALKTFHPTNVLVSGFDIIFFWIARMIMMTMHFIKDDEGKPQVPFKTVYMTGLIRDEEGQKMSKSKGNVLDPLDMIDGITLDKLLEKRTGNMMQPQMAERIAKRTKKEFPEGIEAHGTDALRFTLAALASTGRDINWDMKRLSGYRNFCNKLWNASRFVLMNTEDQDCGYQGGEMTFSLADRWILAEFNNTIKAYREALDNYRFDIAAGILYEFTWNQFCDWYLELSKPAVHKGNDAQKRAARHTLIEVLEGLLRLAHPIIPFITETIWQRVKEVKGIEGETIMLQAFPEFDASLVDEQALNDLEWIKEVIVAVRNIRAEMNIAPGKPLDVILRGADETAKRRVSDNIGFLKAMGRLADIRPLAEGEEAPLSVTKLVSGAELLIPMAGFIDKDAELARLDKELEKVEKDITTLDSKLSNEGFVNRAPEAVVAKERERLASCLNAKEKLIAQKVSIAAL MENENIIEEQKILNFWKEENIFKKSIDNRKNDNPFVFYDGPPTANGLPHTGHVLGRVIKDLFARYKTMQGFYVERKAGWDTHGLPVELGVEKKLGIKDKNEIEKYGIEKFINECKNSVFMYEKQWREFSELIGYWVDMEKPYKTMDNTYIESIWYILSDFHKKGLLYKGHKVTPYCPSCETSLSSHEVAQGYKEVKDISVILKFPILDSDENFLVWTTTPWSLPGNIALAINAEEIYVKVNYDNEIFIIMESLLQSVFKDEDNIDIVSKHKGKEFVGKEYLAPFPNKSLMNNENSYKVLPADFVTNKDGTGIVHIAPAYGEDDYKLVQENNIPFINVIDSRGKYNQDSPIFKGELAKESDINIIKELTHLNLLFKKEKYEHSYPFCWRCDNPLIYYAMEGWFIKTTAYKNEIKENNQKIEWYPDHIKNGRFGNFLDNMIDWNIGRKRYWGTPLNIWKCSTCSHEFSPKSINDLIQHSIEDIPSDIELHRPYIDNVKCKCQNCGGDMCREEEVIDVWFDSGSMPFAQNHYPFSGPIQNSYPADFIAEGVDQTRGWFYSLLVISTIFKGEAPYKNALSLGHILDSNGQKMSKSKGNVIDPISMIKTYGADSLRWTLVSDSVPWTNKRFSENMVAQSKSRVIDTLKNIFNFYNMYQKIDNYDYTRDTPKQLNLLDNWAISRMNSVIKEVELHLEKYNPTNASRAIGEFINEISNWYIRRSRSRFWSSEMNEDKKSAYFTLRLILINTCKIIAPFTPFTSEEIHLNLTKKSVHLEDFPQAKEEYINLKLEEDMNKVLDIVEKSRSIRNNINIKTKQPLSNMYIYDNNNLDNEFLRKYKDIIKDEINVKKINIVSDLDNFLEYDVKPNFSTLGPKLGKDMKQFQILFKNIKKEEMNKLINDFDKLQKVFDSLGVTIEEKDFIISKIPKKGFSLSSNDSDRLIILDTNLTQELIREGFVRELIRVIQQLRKQQNFNIEERINVVIDIDSDGLLSIKNNINILKENVLINNLKFEKRETMKYFKINQKEIGIQLMSSFTN 93.13 gnl|BL_ORD_ID|4707|hsp_num:0 2271 Z1_00585 Acetyltransferase YpeA Loose 340 46.6 sta 28.57 3004699 protein homolog model n/a n/a nucleoside antibiotic antibiotic inactivation streptothricin acetyltransferase (SAT) MTANPNATQNIIIRAIEKRDNAGIARVIREVSAEHGLTADKGFAVADPILDTLFEVYHQPRSAYWVVEMDGEIVGGGGVAPLAGGDGETCELQKMYLSSKLRGKGIAKKIVQQSLEFGKQQGFSRCYLETTDILKAAIGLYEKLGFEFIDKALGNTGHSDCEIRMLKSL MTTTHGSTYEFRSARPGDAEAIEGLDGSFTTSTVFEVDVTGDGFALREVPADPPLVKVFPDDGGSDGEDGAEGEDADSRTFVAVGADGDLAGFAAVSYSAWNQRLTIEDIEVAPGHRGKGIGRVLMRHAADFARERGAGHLWLEVTNVNAPAIHAYRRMGFAFCGLDSALYQGTASEGEHALYMSMPCP 89.42 gnl|BL_ORD_ID|2228|hsp_num:0 3397 Z1_00601 N-acetyltransferase Eis Loose 275 42.0 AAC(6')-33 30.26 3002587 protein homolog model n/a n/a aminoglycoside antibiotic antibiotic inactivation AAC(6') MLIRVEIPVDIPAIDDLLRQSFPTGAEADLVGHLREEGLLTLGMVAINDEGRIVGYIGFTPVDIEGKDCQWVGLAPLAVAPQYRGQGIGRQLINEGLDSLNEFGYGAVVVLGEPTYYQKSGFIPAKSQGLHCKWPNTEEAFQFYALDNGNVDDIHGLVNFSPLFDEV MAYEFCEIGESNEYIILAARILTKSFLDIGNNSWPDMKSATKEVEECIEKPNICLGIHENEKLLGWIGLRPMYKLTWELHPLVISTQYQNKGIGRLLINELEKKAKQIGIIGIVLGTDDEYFKTSLSAVDLYGENILDEIRTIKNIKNHPYEFYQKCGYSIVGVIPDANGKRKPDIWMWKKIND 90.76 gnl|BL_ORD_ID|852|hsp_num:0 924 Z1_00614 hypothetical protein Loose 600 72.0 mdtN 26.77 3003548 protein homolog model n/a n/a nucleoside antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MKKRAIYLILLMLILIALAVLFRAHNQYLLLQGEVDAPEVIVASKAKGRVIERHIERGDDVKAGQLMITLDSPELNAQVAALEAAKAQAQAQLDLSIHGTREESIRNLQAILSQAQAQATNATKDYQRLSAVANKGYVSANELDSARSRRDVAVQQAKAAQAELDEAKNGDRIELREKYRAALQQAEQQLIELKVQQQDLQVKAPVDGEVGPIPAEVGELFNANSPLATLIRLPEAYFVYNLREDILADIRKGDRITITVPALGNKEVEAEVRYIAPMGDYATKRATRATGDFDLKTFEVRLYPTAQIEGLRPGMSALWRWDK MESTPKKAPRSKFPALLVVALALVALVFVIWRVDSAPSTNDAYASADTIDVVPEVSGRIVELAVTDNQAVKQGDLLFRIDPRPYEANLAKAEASLAALDKQIMLTQRSVDAQQFGADSVNATVEKARAAAKQATDTLRRTEPLLKEGFVSAEDVDRARTAQRAAEADLNAVLLQAQSAASAVSGVDALVAQRAAVEADIALTKLHLEMATVRAPFDGRVISLKTSVGQFASAMRPIFTLIDTRHWYVIANFRETDLKNIRSGTPATIRLMSDSGKTFEGKVDSIGYGVLPDDGGLVLGGLPKVSRSINWVRVAQRFPVKIMVDKPDPEMFRIGASAVANLEPQ 94.17 gnl|BL_ORD_ID|1324|hsp_num:0 1442 Z1_00616 Transcriptional regulatory protein BtsR Loose 390 52.0 evgA 30.86 3000832 protein homolog model n/a n/a macrolide antibiotic; fluoroquinolone antibiotic; penam; tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump MNILIVDDEPLARENLRCLLEEEKDIHIIGECSNAIEAIGEIHRKKPDVVFLDIQMPRITGLEMVSMLDPEHRPYIVFLTAFEEYAIQAFEEHAFDYLLKPLEQERLAKTLSRLRQGNKQNIDLLSPPEERLKCIPCTGHSRIWLMPIDEAVFATSRLSGVYVTNNQGQEGFTELTLRTLETRTPLVRCHRQYLVNMDYVNEIVFGDNGQAELILHNNKQIPVSRRYLKPLKEAIGLI MNAIIIDDHPLAIAAIRNLLIKNDIEILAELTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQVLETLRKRQYSGIIIIVSAKNDHFYGKHCADAGANGFVSKKEGMNNIIAAIEAAKNGYCYFPFSLNRFVGSLTSDQQKLDSLSKQEISVMRYILDGKDNNDIAEKMFISNKTVSTYKSRLMEKLECKSLMDLYTFAQRNKIG 116.67 gnl|BL_ORD_ID|939|hsp_num:0 1015 Z1_00629 Translation initiation factor IF-2 Loose 275 66.6 Streptomyces rimosus otr(A) 35.77 3002891 protein homolog model n/a n/a tetracycline antibiotic antibiotic target protection tetracycline-resistant ribosomal protection protein MTDETVKSLAEEIQTPVERLVQQFADAGIKKTVSDSVSQKEKETLLAWLNRDKESTSQPEKLTLQRKVRSTLSVPGTGGKNKSVAIEVRKKRTYVNRDAVEKAQAAEQAQREAEEKARREAEEKAQREAQEKAQREAEEKAKREAEEAKKKAEEKAKREAEEAKREAAELAKREAAEKDKVKQNEKPKADKADQEKARRIAEQAELKRKTEEAQRRKAEEEARIAAEKARRLAEENAEKWTSDTSSETEGTDYHVTTSRYARDAEDESDAEVEGGRGRGRAAKAPRPKKNNRHSEKADREEARAAGRSNKKGKGRKNSTLQQGFNKPAAAVNRDVVIGETISVADLANKMAVKGSEVIKTMMKMGAMATINQVLDQETAQLVAEEMGHKVILRRENELEEQVMNDRDTSDEMAVSRAPVVTIMGHVDHGKTSLLDYIRSTKVASGEAGGITQHIGAYHVKTDKGEITFLDTPGHAAFTSMRARGAQVTDIVVLVVAADDGVMPQTIEAIQHAKAANVPVVVAVNKIDKPEADPDRVKTELSQYGILPEDWGGETQFIHVSAKQGLGIDELLDAILLQAEVLELKAVKEGMASGVVIESYLDKGRGPVATILVREGTLNKGDIVLCGFEYGRIRAMRNELGKEVQSAGPSMPVEILGLSNVPSAGDEATVVRDEKKAREVALYRQGKFREVKLARQQKSKLENMFANMEEGKVSELNIVLKTDVQGTCEAITDALVKLSTDEVKLKIIGSGVGGITETDATLAAASDAIILGFNVRADASARRIIEQESVDLRYYSVIYSLIDEIKSAMSGMLEPEYKQEIMGLAEVRDVFKSPKFGAIAGCMVVEGNIKRNNPIRVLRDNVVIYEGELESLRRFKDDVNEVRNGMECGIGVKNYNDVRVGDMIEVFQVIEIKRSID MNKLNLGILAHVDAGKTSLTERLLHRTGVIDEVGSVDAGTTTTDSMELERQRGITIRSAVATFVLDDLKVNLIDTPGHSDFISEVERALGVLDGAVLVVSAVEGVQPQTRILMRTLRRLGIPTLVFVNKIDRGGARPDGVLREIRDRLTPAAVALSAVADAGTPRARAIALGPDTDPDFAVRVGELLADHDDAFLTAYLDEEHVLTEKEYAEELAAQTARGLVHPVYFGSALTGEGLDHLVHGIRELLPSVHASQDAPLRATVFKVDRGARGEAVAYLRLVSGTLGTRDSVTLHRVDHTGRVTEHAGRITALRVFEHGSATSETRATAGDIAQAWGLKDVRVGDRAGHLDGPPPRNFFAPPSLETVIRPERPEEAGRLHAALRMLDEQDPSIDLRQDEENAAGAVVRLYGEVQKEILGSTLAESFGVRVRFDPTRTVCIEKPVGTGEALIELDTRTHNYFWGAPWVCASDRPSPARAITFRLAVELGSLPLAFHKAIEETVHTTLRHGLYGWQVTDCAVTLTRTGVRSPVSAADDFRKANARLVLMDALGRAGTEVHEPVSSFELEVPAARLSPVLAKLAELGATPGVPTAEGDVFRLEGTMPTSLVHDFNQRVPGLTQGEGVFLAEHRGYRPAVGQPPVRPRPEGPNPLNRDEYILHVLKRV 138.16 gnl|BL_ORD_ID|4813|hsp_num:0 1273 Z1_00636 Dihydropteroate synthase Loose 500 208.8 sul4 42.54 3004361 protein homolog model n/a n/a sulfonamide antibiotic antibiotic target replacement sulfonamide resistant sul MKLIARGRELNLSSPQVMGILNVTPDSFSDGGTHNSLNDAINHAAKLIAEGASIIDIGGESTRPGASDVSVDEELHRVIPVVEAIQQRFDVWISVDTSKAQVITESAQAGASIINDIRSLTEPGALQAAAKTGLPVCIMHMQGLPKTMQHSPQYKNVMIEVDAFLAENIQRCIDAGIEKNQIILDPGFGFGKNLAHNYQLLAHLSDFHHFGLPILAGMSRKSMVGQLLNVPPQERVAGSVACAVIAAMQGAQIIRVHDVKETVDAMKVVQATLSAKENNE MSTTLTSFKWGERTYIMGILNVTPDSFSGDGVMVEEDVIAKAVAQAKQFVADGADIIDIGGESTRPGSSPISAEEELARVLPVVQAVRQAVDVVISIDSYRASVAEAALAAGASWLNDVWGLRMDPDMAGLAAQAGCPIVLMHNRSKPKNIAQEKKLGGRFIGVKYDDLITDVKRELQESIDIALKAGVKESQIILDPGIGFGKTVEQSLQLLDQINQFKTMGFPILIGPSRKSFIGYTLDLPPDQRIEGTAATVAIGIDRGADVVRVHDVKAIVRVARMTDAIVRR 97.56 gnl|BL_ORD_ID|2492|hsp_num:0 2875 Z1_00675 23S rRNA (guanosine-2'-O-)-methyltransferase RlmB Loose 450 55.1 tsnR 29.71 3003060 protein homolog model n/a n/a peptide antibiotic antibiotic target alteration non-erm 23S ribosomal RNA methyltransferase (A1067) MSEDIIYGIHAVKALLERDPTRFKEVYVLKGREDRRLMPVIHALEEQGILVQVANRQWLDNQTEGAVHQGIIAKVKPSRQYQEQDLPDLLAEVGTPFLLVLDGVTDPHNLGACLRSADAAGVHAVIVPKDRSAQLNATAKKVACGAAESVPLIRVTNLARTLRLLQEENIWIVGTAGEADHTLYQSKLTGPLALVMGAEGEGMRRLTREHCDELISIPMAGSVSSLNVSVATGVCLFEAMRQRISVK MANLDVIVDRSDPAVQRIVDVTKHSRSVVRTVLIEDIEPLTQSIRAGVEFTEVYGLDTVPFPGDLLAACEKRGIRVRLLSAAVANQVFKTEKKPKVFGIAKVPPAGRFADLESLSGDVVLLDGVKIVGNIGAIVRTRSALGAAGIVLVDSGLGTIADRRLIRASRGYVFSLPIVLATRDEALAFFRDGGMRPVVFEADGKLSIGELDGIDERLVLVFGSEKTGPSGEFAGVATESVSIPMNPAAESLNVSVSAGIALHRRARRNLSRPRG 91.48 gnl|BL_ORD_ID|149|hsp_num:0 49 Z1_00748 HTH-type transcriptional regulator HdfR Loose 550 51.2 NmcR 28.17 3003665 protein homolog model n/a n/a carbapenem; cephalosporin; cephamycin; penam antibiotic inactivation NmcA beta-lactamase MDIRDLKLFLHLAESCHFTKTAQAMHVSPSTLSRQIQRLEEQLGHPLFLRDNRQVTLTDAGEQLKRYAQHTLLQYKQLKHTLNQNSPSLSGELRLFCSVTAAYSHLPPILDRFRAENPLVEIKLTTGDAADAVDKVISDEADLGIAGKPEKLPENICFEKIGEIPLVLIAPALPGNVRHLATQEKPDWLNIPFIIPEHGPSRQRIALWFKRHRIQNPLIYATVSGHEAIVSMVALGCGIALIPQVVVDNCPEPVRNRISLLDNISLVEPFELGVCGLHKRLQEPVISAFWRLLHH MRARLPLNALRAFEASARYLNFTKAGLELHVSQAAVSQQVRTLEQMLGVALFTRVPRGLQLTDEGMHLLPSITEALQMMSSAMDKFHEGKIKEVLTIAVVGTFAIGWLLPRITAFLNENPWIDIRILTHNNVVNLAAEGIDASIRFGTGGWINTENILLFQAPHTVLCSPETSKKLYIPSDLKKVCLLRSYRKEEWNNWFKAAGIDPWTITGPIFDSTRLMIDAVKLGDYAALVPYHMFQKELNERSVAKPFEIYATLGGYWLTLQKSRVNHNSEALNVFKEWIIEHSREFVLKS 100.00 gnl|BL_ORD_ID|1908|hsp_num:0 2072 Z1_00756 HTH-type transcriptional regulator HdfR Loose 550 42.0 NmcR 27.13 3003665 protein homolog model n/a n/a carbapenem; cephalosporin; cephamycin; penam antibiotic inactivation NmcA beta-lactamase MDTELLKTFLEVSKTRHFGRAAESLYLTQSAVSFRIRQLETQLGTNLFTRHRNNIRLTLAGERLIPYAESLMNTWLQAKKEISHASQHSELSIGATASLWDAYLTSWLQEAYLERNELRIESRVSTRQSLVKQLHARELDLLFTTEAPKMDELESKVIGNITFQLMKRASHLNQQSAQFIKIEWSADLSPLSQNSSAPKTEPILTTNSAMIAYQLMKTTNAVAFLPTHWLDLYPDLSPAAVEIIQKPLFAVWLNTSDQQVLIQQLLSQPVSNHQ MRARLPLNALRAFEASARYLNFTKAGLELHVSQAAVSQQVRTLEQMLGVALFTRVPRGLQLTDEGMHLLPSITEALQMMSSAMDKFHEGKIKEVLTIAVVGTFAIGWLLPRITAFLNENPWIDIRILTHNNVVNLAAEGIDASIRFGTGGWINTENILLFQAPHTVLCSPETSKKLYIPSDLKKVCLLRSYRKEEWNNWFKAAGIDPWTITGPIFDSTRLMIDAVKLGDYAALVPYHMFQKELNERSVAKPFEIYATLGGYWLTLQKSRVNHNSEALNVFKEWIIEHSREFVLKS 92.88 gnl|BL_ORD_ID|1908|hsp_num:0 2072 Z1_00771 Methionyl-tRNA formyltransferase Loose 1200 127.1 arnA 30.96 3002985 protein homolog model n/a n/a peptide antibiotic antibiotic target alteration pmr phosphoethanolamine transferase MSDSLRIIFAGTPDFAARHLAALLSTQHHIVGVLTPPDKPAGRGKKLTINPVKELALTNNIPVYQPTSLKPEENHEWIKALQPDVMIVVAYGMILPKAVLDIPRLGCLNVHGSLLPKWRGAAPIQRALWAGDTETGVTIMQMDVGLDTGDMLYKASCPITHQDTSASLYAKLAELGPKALINTLDLIISGELKAEKQDDSLANYAEKLSKEEAKINWSLSAQQIERCIRAFNPWPMSFFMLDDQPVKVWEAQVIASDNTNQIPGTLLKADKTGIYIVTGEGILNITKLQPSGKKPMASADFLNSKRDWFTPGKIIQ MTSKAVVFAYHDIGCTGIEALLNAGYEIAAVFTHADDPRENTFYASVARLCAERGIPLHAPEDVNHPLWLERIRQLRPDFLFSFYYRRLLGAELLACAARGAYNLHGSLLPRYRGRAPANWVLVNGETQTGVTLHRMIERADAGPILAQQAVAIDPEDTALSLHGKLRKAAGALLRDSLPLLALGVLPEVEQDESQASHFGRRTPADGLLDWHRPARQLYDLVRAVTQPYPGAFCQVGEQKLIVWSAEVVAGNHGREPGSVLSCDPLRIACGEDSLVLRFGQRGERGLYLAGTQLATELGLVEGARLRGAACSPQRRTRVLILGVNGFIGNHLSERLLRDGRYEVHGMDIGSDAIERLKADPHFHFVEGDIGIHSEWLEYHVKKCDVILPLVAIATPIEYTRNPLRVFELDFEENLRIVRYCVKYGKRVVFPSTSEVYGMCQDPDFDEDRSNLVVGPINKQRWIYSVSKQLLDRVIWAYGQQGLRFTLFRPFNWMGPRLDRLDSARIGSSRAITQLILHLVEGTPIRLVDGGAQKRCFTDVDDGIEALARIIDNRDGRCDGQIVNIGNPDNEASIRQLGEELLRQFEAHPLRAQFPPFAGFREVESRSFYGDGYQDVAHRKPSIDNARRLLDWQPTIELRETIGKTLDFFLHEALREREAQA 47.73 gnl|BL_ORD_ID|1516|hsp_num:0 1643 Z1_00776 HTH-type transcriptional regulator ZntR Loose 290 81.3 golS 35.43 3000504 protein homolog model n/a n/a monobactam; carbapenem; cephalosporin; cephamycin; penam; phenicol antibiotic; penem antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MYRIGQIAKLANVTTDTIRFYEKQGLMEHDRRTEGGYRLYTEQDLQRLRFIRYAKELGFTLDAITELLSIRVDPAHHTCVESKHIVDARLAEVEARLKEMEKMRDSLKMLSNACCGTAHESTYCSILEILESGATKQ MNIGKAAKASKVSAKMIRYYEQIGLIPAASRTDSGYRAYTQADVNQLHFIRRARDLGFSVAEISDLLNLWNNQSRQSADVKRLAQTHIDELDRRIQNMQHMAQTLKALIHCCAGDALPDCPILHTLGQPDDSEPEARTGAVLRRPRRHGLAKRL 88.96 gnl|BL_ORD_ID|36|hsp_num:0 44 Z1_00806 Elongation factor Tu 1 Strict 700 752.3 Escherichia coli EF-Tu mutants conferring resistance to Pulvomycin 94.42 3003369 protein variant model R234F elfamycin antibiotic antibiotic target alteration elfamycin resistant EF-Tu MSKEKFERSKPHVNVGTIGHVDHGKTTLTAAITTVLAKTYGGAARAFDQIDNAPEEKARGITISTSHVEYDTPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFLNKCDMVDDEELLELVEMEVRELLSQYDFPGDDTPVIRGSALKALEGEAEWEAKIVELAEALDTYIPEPERAIDKPFLLPIEDVFSISGRGTVVTGRVERGIIKVGDEVEIVGIKETAKTTCTGVEMFRKLLDEGRAGENVGVLLRGTKREEIERGQVLAKPGSINPHNKFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNVNMIVELIHPIAMDEGLRFAIREGGRTVGAGVVAKVLG MLSPEGESTIVRNIAVSKEKFERTKPHVNVGTIGHVDHGKTTLTAAITTVLAKTYGGAARAFDQIDNAPEEKARGITINTSHVEYDTPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFLNKCDMVDDEELLELVEMEVRELLSQYDFPGDDTPIVRGSALKALEGDAEWEAKILELAGFLDSYIPEPERAIDKPFLLPIEDVFSISGRGTVVTGRVERGIIKVGEEVEIVGIKETQKSTCTGVEMFRKLLDEGRAGENVGVLLRGIKREEIERGQVLAKPGTIKPHTKFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNIKMVVTLIHPIAMDDGLRFAIREGGRTVGAGVVAKVLG 96.33 gnl|BL_ORD_ID|1973|hsp_num:0 2158 Z1_00827 Hydrogen peroxide-inducible genes activator Loose 650 48.1 adeL 26.12 3000620 protein homolog model n/a n/a fluoroquinolone antibiotic; tetracycline antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MNIRDLEYLVALAEHKHFRRAADSCHVSQPTLSGQIRKLEDELGVMLLERTSRKVLFTQQGLLLVEQAKTVLREVKVLQEMASLQGESMAGPLHIGLIPTVGPYLLPHIIPELHRNYPKLEMYLHEAQTNSLLAQLDSGKLDCAILAMVKESAPFIEVPLFEEPMKLAIYDEHPWHDRKSVPMGDLAGQRLLMLEDGHCLRDQALGFCFQAGAKEDTHFRATSLETLRNMVAAGSGITLLPDLAVPQAQKRDGVCYLDCTSPNPSRSIILAYRPGSPLRNRYEQLAETIRDHMTAFYEAKKAASK MRVFNKVVETNSFSLAADSLGLPRASVTTTIQALEKHLQVRLLNRTTRKISLTPDGAVYYDRTARILADVADIESSFHDAERGPRGQLRIDVPVSIGRLILIPRLRDFHARYPDIDLVIGLNDRPVDLVGEAVDCAIRVGELKDSSLIARRIGTFQCATAASPIYLEKYGEPTSIEDLQKNHKAIHFFSSRTGRNFDWDFVVDDLIKSVSVRGRVSVNDGDAYIDLALQGFGIIQGPRYMLTNHLESGLLKEVLPQWTPAPMPISAVYLQNRHLSLKVKVFVDWVAELFAGCPLLGGTALPFDQKCEFACDKETGHEYTIRTLVEQHNIAEAYTLKT 90.50 gnl|BL_ORD_ID|2323|hsp_num:0 2654 Z1_00838 Proline/betaine transporter Loose 700 233.4 Acinetobacter baumannii AbaF 31.62 3004573 protein homolog model n/a n/a phosphonic acid antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MKLKKKRNKPLRINDITIIDDSKLKKAITAAALGNAMEWFDFGVYGFLAYVLGQVFFPGASPGVQMIAALATFSVPFLVRPLGGVVFGMLGDKFGRQKVLSVTIIIMALSTFAIGLIPGYDTIGIWAPVLLLLAKLAQGFSIGGEYSGAAIFVAEYSPDRKRGFMGSWLDFGSIAGFVMGAGVVVLISTIMGEAAFHEWGWRIPFFLALPLGLIGLYLRHALEETPAFQQHVDEMNSDDRKSIENPPRVSLREIASKYWKSLTVCVGLVIATNVTYYMLLTYMPSYLSHNLNYSADHGVLIIIAIMIGMLFVQPVIGLLSDKIGRKPFVIGGSVGLFILAYPAFMMINSDEIGLIFLGLLILAVLLNCFTGVMASILPAIFPTHIRYSALAIAFNISVLIAGATPTAAAWLVEATGNLYMPAYYLMVVAVVGLITGIKMIETANKPLRGATPAASDKSEAKEILSEHYDNIEQRVEDIEAEIEALQKKRQALIDQHPKLD MTTTLKKVVAASMVGSVAEWYEFFLYGTASALVFGELFFQQTGNAIDGILAAFALYAVGFLARPLGGLVFGHYGDKIGRKKLLQISLIIVGITTFLMGCIPTFHQIGYWAPTLLVILRLIQGFAFGGEWGGAVILVSEHSPDDRRGYWASWPQTGVPLGNLVATLVLLLLSKNLSPEQFLDWGWRCAFWFSAVVVLIGLWIRKNVDDAEVFKEAQAKQQLLEKQQLGIIEVLKYHKKSVIAGIGARFAENILYYMVVTFSISYLKLVVHKDTSQILLLMFGAHLIHFFIIPFMGHLSDIFGRKPIYLIGAVLTAFWGFVGFPLMDTGNDWLIMLAIVLGLFIESMTYSPYSALMTELFPTHIRYTALSFCYQVAPIMAGSLAPLIALTLLKEFNSSIPISLYLVAASLISIVSILLVKETKGRSLAFKD 116.55 gnl|BL_ORD_ID|2725|hsp_num:0 3277 Z1_00840 Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase Loose 550 49.7 PmrF 29.03 3003578 protein homolog model n/a n/a peptide antibiotic antibiotic target alteration pmr phosphoethanolamine transferase MKTPIISVIVPMFNEASRITRLLESLLCQTFHDFEVIIINDGSTDNSVDIAMLYCQQDNRFHLYHQTNQGLSSARNTGLKYAQGDWIVFFDSDDFIKPQLLAHWHQLACEQHIDVLIGNGERYDVHNPQKHQTTIHQRQPYQQVISGQEWVIHAVTQHQWPHFVWLQFIRHEIIKKHHLRFIDGLYHEDILWTTQLALVTQRIGFDDQPLYYYCANPNSITRKPNPQKEAKRAQSYLQIVIQLLQLADKQHQPLLANALRQQALRELGSFFILFRKRCDTKNQAIIAQQFRTYHLFPALNKGAQNWHQRWFICRVYCVLYWHRWKKR MFEIHPVKKVSVVIPVYNEQESLPELIRRTTTACESLGKEYEILLIDDGSSDNSAHMLVEASQAENSHIVSILLNRNYGQHSAIMAGFSHVTGDLIITLDADLQNPPEEIPRLVAKADEGYDVVGTVRQNRQDSWFRKTASKMINRLIQRTTGKAMGDYGCMLRAYRRHIVDAMLHCHERSTFIPILANIFARRAIEIPVHHAEREFGESKYSFMRLINLMYDLVTCLTTTPLRMLSLLGSIIAIGGFSIAVLLVILRLTFGPQWAAEGVFMLFAVLFTFIGAQFIGMGLLGEYIGRIYTDVRARPRYFVQQVIRPSSKENE 101.55 gnl|BL_ORD_ID|1940|hsp_num:0 2014 Z1_00859 Multidrug resistance protein D Loose 500 107.5 bcr-1 26.19 3003801 protein homolog model n/a n/a bicyclomycin-like antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MRKLEHANLLLLIIALVAVGQMTQTIYVPVIADMAVYFGEPTGAVQQVMGAYLFSYGFSQLIYGPISDRVGRRPVILVGMSIFCLATIVAIFSQNLTTLVIASTLQGMGTGVAGVMTRTQPRDLYTGTALRYANSLLNMGVLVSPLLAPMIGGVVAHFFGWHACYIFLLLLGGSVLFSMYHWMPETRPVQAERRSMLSSFYLLLSNSTFSAFLIMLICALSGIAVFEASSGVLMGGVLGLNSITISILFILPIPAAFFGAWYAGREGKTFVQLMWHSVFCCVAAGILMWLPGWLNIINIWTLLVPAALFFFGAGMLFPLATTGAMEPFPYLAGAAGALVGGLQNVGSGIATWFSALLPQHNQFSLGMIMFIMSVAIMLCWIPLSHRFSHQQNTV MPASASRIQVGSGERRLLLLLSALVAFGPLSIDMYLPSLPAIAADLGASDAQVQRSISGFLVGFCVGMLFYGPLSDRFGRRPVLLAGIALYLFSSLACALADSAGQLVLLRVLQALGGGAASVLARAMVRDLYPLGEAARMLALMHMVTMLAPLAAPLLGGYLMLWAGWRALFVVLALFAGLCLLAVWRVAESHPPERRGGSLAQAFLAYGRLLGDRRALGYVLCMGLAFAGMFAYISAAPFVFIEHFGVRAERFGWFFGLNILGVMLATWCSARLVRRHGPRPLLRAGSLLACVSGLFLLGYAALGERGGLWALVPGLLCFVSVTGLLGANCIASLLALYPGQAGAASAVAVSGQFGLGCLASLAVGWLALPGVLPMALVMAVCGVGSLLALGLALHGGNR 98.01 gnl|BL_ORD_ID|2340|hsp_num:0 2303 Z1_00870 Transcriptional regulatory protein CpxR Loose 400 189.1 Pseudomonas aeruginosa CpxR 46.05 3004054 protein homolog model n/a n/a macrolide antibiotic; fluoroquinolone antibiotic; monobactam; aminoglycoside antibiotic; carbapenem; cephalosporin; cephamycin; penam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; penem antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MHKILLVDDDRELTSLLKELLEMEGFNVVLATDGEQALKLLDASIDLLLLDIMMPRKNGIETLKELRQNFQTPVIMLTARGSDLDRVLGLELGADDYLPKPFNDRELVARIRAILRRSNWSEQKQTDGNTSPILQVDKLQLNPGRQEASFDNEPLELTGTEFTLLYLLAQHLGQVVSREHLSQEVLGKRLTPFDRAIDMHISNLRRKLPERTDGQPWFKTLRGRGYLMVSIT MSELLLIDDDRELCELLGTWLVQEGFSVRASHDGAQARRALAEQTPDAVVLDVMLPDGSGLELLKQLRGDHPDLPVLMLSARGEPLDRILGLELGADDYLAKPCDPRELTARLRAVLRRTHPAQPSAQMQLGDLSLNLTRGVAQIDGQEISLTLSESRILEALLRQPGEPLDKQALAQLALGRKLTLYDRSLDMHVSNLRKKLGSHPDGSPRILALRGRGYYYSH 103.11 gnl|BL_ORD_ID|2308|hsp_num:0 2685 Z1_00871 Sensor histidine kinase CpxA Loose 890 734.9 cpxA 79.2 3000830 protein homolog model n/a n/a aminoglycoside antibiotic; aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MINSLSARIFAIFWLTLALVLVLVMMVPKLDSRQLTTLLESEYRQGVMLEQHIEAELAQDPANDLLWWRRLIRAIDKWAPPGQRLIIVTSEGRIIGAQRNEIQVVRNFMGQSDNADHPKKKKYGRSEMLGPFSIRDGEDHYQLYLVRPSSSPQSDFINLLFDKPLLLLIFTMLISTPLLVWLSWSLAKPARKLKNAADDVAKGNLRPHPELETGPQEFLAAGTSFNQMISALERMVEAQQRLISDISHELRTPLTRLQLASALLRRRSGESKELERIETETQRLDGMINDLLVLSRNQYKNELLRETVKANELWNDILDNAKFEAEQSNKTLTVTAPPGPWTIYCNPYSLASAFENIVRNALRYSHSRIEVAFTEQNQGITIIVDDDGPGVSPEDREHIFRPFYRTDEARDRESGGTGLGLAIVETAISQHRGHVKADDSPLGGLRVEIWLPRGSVVNKLNNN MIGSLTARIFAIFWLTLALVLMLVLMLPKLDSRQMTELLDSEQRQGLMIEQHVEAELANDPPNDLMWWRRLFRAIDKWAPPGQRLLLVTTEGRVIGAERSEMQIIRNFIGQADNADHPQKKKYGRVELVGPFSVRDGEDNYQLYLIRPASSSQSDFINLLFDRPLLLLIVTMLVSTPLLLWLAWSLAKPARKLKNAADEVAQGNLRQHPELEAGPQEFLAAGASFNQMVTALERMMTSQQRLLSDISHELRTPLTRLQLGTALLRRRSGESKELERIETEAQRLDSMINDLLVMSRNQQKNALVSETIKANQLWSEVLDNAAFEAEQMGKSLTVNFPPGPWPLYGNPNALESALENIVRNALRYSHTKIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAIVETAIQQHRGWVKAEDSPLGGLRLVIWLPLYKRS 101.31 gnl|BL_ORD_ID|132|hsp_num:0 152 Z1_00886 UDP-glucose 6-dehydrogenase Loose 700 609.4 ugd 76.29 3003577 protein homolog model n/a n/a peptide antibiotic antibiotic target alteration pmr phosphoethanolamine transferase MKITISGTGYVGLSNGILLSQHNKVVALDINKEKVELLNQKISPISDKEIEEFLATKELDFTATLDKEFAYKDAEFVIIATPTDYDPKTNYFNTSSVESVIRDVLEYNPNTTMIIKSTIPVGFTKQMREKYHTDNIIFSPEFLREGRALYDNLYPSRIVIGEQSARAEKFAELLQQGALKKDIDVLFTDSTEAEAIKLFANTYLALRVAYFNELDSYAQAYGLNARQIIEGVCLDPRIGNHYNNPSFGYGGYCLPKDTKQLLANYESVPNNIIGAIVEANRTRKDFIADSIIAKSPKIVGVYRLIMKSGSDNFRSSSIQGIMKRIKAKGIEVVIYEPEMKEETFFNSKLIRDLDAFKAMSDVIITNRMASALNDVEEKVYTRDLFGND MKITISGTGYVGLSNGLLIAQNHEVVALDILPSRVAMLNDRISPIVDKEIQQFLQSDKIHFNATLDKNEAYRDADYVIIATPTDYDPKTNYFNTSSVESVIKDVVEINPYAVMVIKSTVPVGFTAAMHKKYRTENIIFSPEFLREGKALYDNLHPSRIVIGERSERAERFAALLQEGAIKQNIPMLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYAESLGLNSRQIIEGVCLDPRIGNHYNNPSFGYGGYCLPKDTKQLLANYQSVPNNLISAIVDANRTRKDFIADAILSRKPQVVGIYRLIMKSGSDNFRASSIQGIMKRIKAKGVEVIIYEPVMKEDSFFNSRLERDLATFKQQADVIISNRMAEELKDVADKVYTRDLFGSD 100.00 gnl|BL_ORD_ID|897|hsp_num:0 842 Z1_00889 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase Loose 400 38.1 vatE 48.78 3002844 protein homolog model n/a n/a streptogramin antibiotic; streptogramin A antibiotic antibiotic inactivation streptogramin vat acetyltransferase MHAQAKVTLAELKDCLQAEYIGDKKPFSWLRLFHRVFFCQRSRYLFWWRVAQYFYFSPHRFLHKLGIRIGASNNRKYCNDISLKTRIGKGLSLPHPIGIVLTNYCQLGEYVTIMQGVTIGVKEKGGKANIQVGNHVYIGCNSSIIGGEINIGDNAIIGAHALVLKDVGEGCRYITKVIADIRRV MTIPDANAIYPNSAIKEVVFIKNVIKSPNIEIGDYTYYDDPVNPTDFEKHVTHHYEFLGDKLIIGKFCSIASGIEFIMNGANHVMKGISTYPFNILGGDWQQYTPELTDLPLKGDTVVGNDVWFGQNVTVLPGVKIGDGAIIGANSVVTKDVAPYTIVGGNPIQLIGPRFEPEVIQALENLAWWNKDIEWITANVPKLMQTTPTLELINSLMEK 85.98 gnl|BL_ORD_ID|1401|hsp_num:0 1519 Z1_00931 dTDP-fucosamine acetyltransferase Loose 350 43.1 SatA 27.03 3005045 protein homolog model n/a n/a nucleoside antibiotic antibiotic inactivation streptothricin acetyltransferase (SAT) MSTISMAVSVQLIEQEHYAQWLPYWLSYQEFYNVELSEEITLKTWARFFDEKEPIYCAVATDGKKILGFVHYLFHRSTWAESDFCYLEDLFVSPEARGCHVGKKLIDFVNQQAKQRNCARLYWHTQETNLRGQRLYDWVAEKPGVIEYRMAL MSLLIRELETNDLDNFPEIDDSFIVNARLMLSLSKVNRRIEYTVEDVPSYEKSYLQNDNEELVYNEYINKPNQIIYIALLHNQIIGFIVLKKNWNNYAYIEDITVDKKYRTLGVGKRLIAQAKQWAKEGNMPGIMLETQNNNVAACKFYEKCGFVIGGFDFLVYKGLNMTSDEVAIYWYLHFDS 82.61 gnl|BL_ORD_ID|2784|hsp_num:0 3788 Z1_00967 Beta-lactamase PSE-1 Strict 500 594.3 CARB-3 99.67 3002242 protein homolog model n/a n/a penam antibiotic inactivation CARB beta-lactamase MLLYKMCDNQNYGVTYMKFLLAFSLLIPSVVFASSSKFQQVEQDVKAIEVSLSARIGVSVLDTQNGEYWDYNGNQRFPLTSTFKTIACAKLLYDAEQGKVNPNSTVEIKKADLVTYSPVIEKQVGQAITLDDACFATMTTSDNTAANIILSAVGGPKGVTDFLRQIGDKETRLDRIEPDLNEGKLGDLRDTTTPKAIASTLNKFLFGSALSEMNQKKLESWMVNNQVTGNLLRSVLPAGWNIADRSGAGGFGARSITAVVWSEHQAPIIVSIYLAQTQASMAERNDAIVKIGHSIFDVYTSQSR MLLYKMCDNQNYGVTYMKFLLAFSLLIPSVVFASSSKFQQVEQDVKAIEVSLSARIGVSVLDTQNGEYWDYNGNQRFPLTSTFKTIACAKLLYDAEQGKVNPNSTVEIKKADLVTYSPVIEKQVGQAITLDDACFATMTTSDNTAANIILSAVGGPKGVTDFLRQIGDKETRLDRIEPDLNEGKLGDLRDTTTPKAIASTLNKLLFGSALSEMNQKKLESWMVNNQVTGNLLRSVLPAGWNIADRSGAGGFGARSITAVVWSEHQAPIIVSIYLAQTQASMAERNDAIVKIGHSIFDVYTSQSR 100.00 gnl|BL_ORD_ID|421|hsp_num:0 467 Z1_00968 Multidrug transporter EmrE Perfect 190 224.2 qacEdelta1 100.0 3005010 protein homolog model n/a n/a disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MKGWLFLVIAIVGEVIATSALKSSEGFTKLAPSAVVIIGYGIAFYFLSLVLKSIPVGVAYAVWSGLGVVIITAIAWLLHGQKLDAWGFVGMGLIIAAFLLARSPSWKSLRRPTPW MKGWLFLVIAIVGEVIATSALKSSEGFTKLAPSAVVIIGYGIAFYFLSLVLKSIPVGVAYAVWSGLGVVIITAIAWLLHGQKLDAWGFVGMGLIIAAFLLARSPSWKSLRRPTPW 100.00 gnl|BL_ORD_ID|2753|hsp_num:0 3755 Z1_00969 Dihydropteroate synthase Perfect 500 548.9 sul1 100.0 3000410 protein homolog model n/a n/a sulfonamide antibiotic antibiotic target replacement sulfonamide resistant sul MVTVFGILNLTEDSFFDESRRLDPAGAVTAAIEMLRVGSDVVDVGPAASHPDARPVSPADEIRRIAPLLDALSDQMHRVSIDSFQPETQRYALKRGVGYLNDIQGFPDPALYPDIAEADCRLVVMHSAQRDGIATRTGHLRPEDALDEIVRFFEARVSALRRSGVAADRLILDPGMGFFLSPAPETSLHVLSNLQKLKSALGLPLLVSVSRKSFLGATVGLPVKDLGPASLAAELHAIGNGADYVRTHAPGDLRSAITFSETLAKFRSRDARDRGLDHA MVTVFGILNLTEDSFFDESRRLDPAGAVTAAIEMLRVGSDVVDVGPAASHPDARPVSPADEIRRIAPLLDALSDQMHRVSIDSFQPETQRYALKRGVGYLNDIQGFPDPALYPDIAEADCRLVVMHSAQRDGIATRTGHLRPEDALDEIVRFFEARVSALRRSGVAADRLILDPGMGFFLSPAPETSLHVLSNLQKLKSALGLPLLVSVSRKSFLGATVGLPVKDLGPASLAAELHAIGNGADYVRTHAPGDLRSAITFSETLAKFRSRDARDRGLDHA 100.00 gnl|BL_ORD_ID|982|hsp_num:0 1070 Z1_00973 Multidrug efflux pump Tap Loose 700 136.7 tap 28.92 3000343 protein homolog model n/a n/a tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MSERRYSPLATLFAATFLFRIGNAVAALALPWFVLSHTKSAAWAGATAASSVIATIIGAWVGGGLVDRFGRAPVALISGVVGGVAMASIPLLDAVGALSNTGLIACVVLGAAFDAPGMAAQDSELPKLGHVAGLSVERVSSLKAVIGNVAILGGPALGGAAIGLLGAAPTLGLTAFCSVLAGLLGAWVLPARAARTMTTTATLSMRAGVAFLWSEPLLRPLFGIVMIFVGIVGANGSVIMPALFVDAGRQVAELGLFSSMMGAGGLLGIAIHASVGARISAQNWLAVAFCGSAVGSLLLSQLPGVPVLMLLGALVGLLTGSVSPILNAAIYNRTPPELLGRVLGTVSAVMLSASPMVMLAAGAFVDLAGPLPGLVVSAVFAGLVALLSLRLQFATMAAAATASAPTHTEGEH MTNTKRGPLLLILFAALTAGAGNGITIVAFPWLVLQHNGSALDASIVAMAGTLPLLVATLIAGAAVDYLGRRRVSMISDLLSALSVAAVPVLALIFGVDAVNVAVLAVLAGLGAFFDPAGMTARETMLPEAAGRAGWTLDHANSVYEAVFNLGYIVGPGIGGLMIATLGGINTMWVTAGAFCCSILAISVLRLEGAGAPDRSVLTEAVLAGIVEGLRFVWYTPVLRTLAIVDLVATGLYMPMESVLFPKYFTDRNEPTELGWVLMALSIGGLLGALGYAVMSRYMSRRATMLTAVITLGVAMTVIAFLPPLPLILVLCAIVGFVYGPIAPIYNYVMQTTAPQHLRGRVVGVMGSLAYAAGPLGLILAGPLADAAGLHATFLALSLPMLLLGVVAVFLPRLRELDLASKP 100.73 gnl|BL_ORD_ID|1580|hsp_num:0 1720 Z1_00974 hypothetical protein Perfect 500 593.6 mphA 100.0 3000316 protein homolog model n/a n/a macrolide antibiotic antibiotic inactivation macrolide phosphotransferase (MPH) MTVVTTADTSQLYALAARHGLKLHGPLTVNELGLDYRIVIATVDDGRRWVLRIPRRAEVSAKVEPEARVLAMLKNRLPFAVPDWRVANAELVAYPMLEDSTAMVIQPGSSTPDWVVPQDSEVFAESFATALAALHAVPISAAVDAGMLIRTPTQARQKVADDVDRVRREFVVNDKRLHRWQRWLDDDSSWPDFSVVVHGDLYVGHVLIDNTERVSGMIDWSEARVDDPAIDMAAHLMVFGEEGLAKLLLTYEAAGGRVWPRLAHHIAERLAFGAVTYALFALDSGNEEYLAAAKAQLAAAE MTVVTTADTSQLYALAARHGLKLHGPLTVNELGLDYRIVIATVDDGRRWVLRIPRRAEVSAKVEPEARVLAMLKNRLPFAVPDWRVANAELVAYPMLEDSTAMVIQPGSSTPDWVVPQDSEVFAESFATALAALHAVPISAAVDAGMLIRTPTQARQKVADDVDRVRREFVVNDKRLHRWQRWLDDDSSWPDFSVVVHGDLYVGHVLIDNTERVSGMIDWSEARVDDPAIDMAAHLMVFGEEGLAKLLLTYEAAGGRVWPRLAHHIAERLAFGAVTYALFALDSGNEEYLAAAKAQLAAAE 100.00 gnl|BL_ORD_ID|1142|hsp_num:0 1243 Z1_01004 Putative transferase YhbX Loose 1000 95.1 MCR-8.1 24.69 3004516 protein homolog model n/a n/a peptide antibiotic antibiotic target alteration MCR phosphoethanolamine transferase MVNFLFYMEKGDNDKSMSQVINFSLLFILSIVPALLAGSTLHIEQKFSMVIIGWLLMLLCAGIYRFTIGKVITFIVAALWSLNLSISLFFYREHDIPFSSSIAETFINTNGSETVGMLSYNKYYVLFYIVIFTCFFYLIHISARYLNNKTNKRCLIAIFILIILISLYKNLAIRSESKTQLLAEYYLLNTPFYNAAALVRTFHENRQIKKITSEKVNFNYDKVDQKTEIYILLIGESVRRDHLGIYGYPYDTTPNLEKEKNNILLFKQAYSPAPVTILSVPISLSNINLTELYDKKHYADNIISLANHAGFKTYWLSNQGKGNPKTSVISVIANMAQHKKWNEFIGYDEELLPFLDNALNDNSSNKKLIVLHTYGSHEPACNRFPSTYLKTFSQQEDDNCYDSSIAYTDKLISQIIEKIQDKPASILYFSDHALQRLDKNREVRYHHGVNSPRQEAYNIPLFIWYSASATRPNINKENLNKPFSTADNYWLLSQWLGIEHNSAKKCYSPLSECYQTKTSMMVIDGNKKLLNYALLESEEQAPQ MFKYLLSFKLNPVQRTWAAAFFFTTIGNIALWQTLWINVDVHNIHNLLFFASLPIFLFCFLSILLTPVMVIPYLCRPLLVVLILISACCSYFMMKYNILIDRSMVQNFFETNQAELTSYLSVPFLSTLFLLGIVPAIILALPSTDNKRGAFRIELWWLAHICIAVVLLAMVTMVFYKDYASLIRNNMQIKDQALPFNFVRNTNGYLKRKYQASSTILQSVGEDAVRPIYSNAPPKLVVVVVGETARAQNFQLNGYSRVTNPYLSRRHDVISFKNVSSCGTATAISLPCMFSRMSRNEYNEVRAASEENLLDILKRTGVEVLWRNNNNGGCKGICKRVPTDDMPAMKVIGECVNKDGTCFDEVLLNQLSSRINAMQGDALIVLHQMGSHGPTYFERYPSTSKVFSPTCDSNLIEKCSNKELVNTYDNTLVYTDRMLSKTIELLQRYSGMRDVAMIYLSDHGESLGESGIYLHGTPYIIAPNEQTHIPMFMWFSSSFAQHSKLNLECLTGNADKQYSHDNFYHSILGLFNVKTSVYKPELDMFTLCRQSDHTPLSSAVVREKTDGNG 96.11 gnl|BL_ORD_ID|4727|hsp_num:0 3144 Z1_01013 putative transport protein HsrA Loose 900 156.0 emrY 29.56 3000254 protein homolog model n/a n/a tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MAFFMQSLDATILNTALPDIAKSLNHSPLAMQSAVISYTLTVALLIPVSGWLADRFGTRKIFIIAVSLFSGGSLLCALSPNLAFLVISRVIQGIGGAMMMPVARLALLRAYPRSELLPILNFVTMPGLVGPIAGPLLGGILVTYASWHWIFIINIPIGLLGIFYAIKHMPNFTMPKRKFDLLGFIFFGFGLVMLSVSLDLFGDKNISRYIPLAVILGGFFLLGLYINHAKRHQQPLIPLNIFKTRTFSVGIAGNIATRLGTGCIPFLMPLMLQVGFGYPAIISGMMMAPMALGSILAKSFVTKVLVTFSYRRTLFGITIIIGLMIAQFSLQSPDMSIYYLVLPLFLLGVVMSIQFTSMNTISLADLTDNNASSGNSVLAVTQQLAISFGIAVSASILNYFDAENAGSTVDNFHYTFITVGAITLLSSFVFLLLNKHDGDNLTNKKKNEN MAITKSTPAPLTGGTLWCVTIALSLATFMQMLDSTISNVAIPTISGFLGASTDEGTWVITSFGVANAIAIPVTGRLAQRIGELRLFLLSVTFFSLSSLMCSLSTNLDVLIFFRVVQGLMAGPLIPLSQSLLLRNYPPEKRTFALALWSMTVIIAPICGPILGGYICDNFSWGWIFLINVPMGIIVLTLCLTLLKGRETETSPVKMNLPGLTLLVLGVGGLQIMLDKGRDLDWFNSSTIIILTVVSVISLISLVIWESTSENPILDLSLFKSRNFTIGIVSITCAYLFYSGAIVLMPQLLQETMGYNAIWAGLAYAPIGIMPLLISPLIGRYGNKIDMRLLVTFSFLMYAVCYYWRSVTFMPTIDFTGIILPQFFQGFAVACFFLPLTTISFSGLPDNKFANASSMSNFFRTLSGSVGTSLTMTLWGRRESLHHSQLTATIDQFNPVFNSSSQIMDKYYGSLSGVLNEINNEITQQSLSISANEIFRMAAIAFILLTVLVWFAKPPFTAKGVG 87.70 gnl|BL_ORD_ID|492|hsp_num:0 540 Z1_01031 Bifunctional protein GlmU Loose 400 40.4 vatB 25.69 3002841 protein homolog model n/a n/a streptogramin antibiotic; streptogramin A antibiotic antibiotic inactivation streptogramin vat acetyltransferase MSNSAKSVVILAAGKGTRMYSQLPKVLHKLAGKSMVQHVIDTAKSLGAQQTHLVYGHGGELMKETLGSQPVNWVLQAEQLGTGHAMQQAAPFFADDEDILMLYGDVPLITKETLERLIAVKPAGGIGLLTVILDNPMGYGRIVRENGDVVGIVEQKDASEEQLKIKEINTGILVANGGDLKRWLAKLDNNNAQKEYYITDIIALAHQEGRKIETAHPTRHSEMEGVNNRLQLAALERIYQTEQAERLLLEGVMLLDPARFDLRGTLTHGKDVVIDTNVIIEGEVTLGNNVEIGTGCVLKNCVIGDGSIISPYTVIEDANLAQECTVGPFARLRPGAQLADKAHVGNFVEMKKASLGVGSKAGHLTYLGDTEVGANVNIGAGTITCNYDGANKFKTIIGDDVFIGSDTQLVAPVCVANGATIGAGTTLTKDVNENELVISRVKQTHISGWKRPVKKKQ MKYGPDPNSIYPHEEIKSVCFIKNTITNPNIIVGDYTYYSDVNGAEKFEEHVTHHYEFRGDKLVIGKFCAIAEGIEFIMNGANHRMNSITTYPFNIMGNGWEKATPSLEDLPFKGDTVVGNDVWIGQNVTVMPGIQIGDGAIVAANSVVTKDVPPYRIIGGNPSRIIKKRFEDELIDYLLQIKWWDWSAQKIFSNLETLCSSDLEKIKSIRD 215.57 gnl|BL_ORD_ID|1099|hsp_num:0 1189 Z1_01033 Sulfate/thiosulfate import ATP-binding protein CysA Loose 500 116.3 RanA 29.91 3005091 protein homolog model n/a n/a aminoglycoside antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MLQFNINSQNGSMPHIRVENIQKRFNQFIALDGVSLEIKQGELVCLLGPSGCGKTTLLRCIAGLETQDHGSIFNYDNNISHLPPQARDYGILFQSYALFPNLTVQQNIAYGLAGQPRNVIKNRVNEMLELVGLQDRKKKYPGELSGGQQQRVALARALAPAPSLLLLDEPMSALDAQVREHLCVELRNLQQSLNITTLMVTHNQDEAMLMADRIAVMNNGKVEQYGSSEEIYNHPQTPFVAEFVGKGNWLPFNRNQHGEAMIGSREVQLKHTAVPHNQGRLFC MIEVKDLRKSFNDVEVLKGITTTFETGKINLVIGQSGSGKTVFLKCLLNVFDPSSGDILFDGRNLSIMGRTEKQEIRSEIGTVFQGSALFDSMTVEENISFPLDMFTNLTYTEKRKRVKEVIGRVHLENANTKFPSEISGGMQKRVAIARAIVNNPKYLFCDEPNSGLDPNTAIVIDELIKEITEEYNTTTIINTHDMNSVLTIGEKIVYLRKGVKEWEGNKDLIIKAENEHLIDFVYSSALFKQVRETMLRNNQTNL 109.69 gnl|BL_ORD_ID|2817|hsp_num:0 3825 Z1_01043 Tetracycline repressor protein class B from transposon Tn10 Loose 400 99.0 tetR 33.01 3003479 protein overexpression model n/a n/a tetracycline antibiotic antibiotic target alteration; antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MKSSKIDRLNVLDTALSLLEKEGIEGLTMRKLADALHIKAASLYWHFDNKQTLIEGMADRIVSEVAVDFHYSQDWKADLKRLATELREAFLQHRDGARVFAGTYVISENVLRINNTLITLIMQSGASAELASNMSMTLLYFILGCCIEQQAITLIDSEILMQKRLAFEQIVRDKYPQTWQVREILFADDFAMRFNFGLEQLVTGFEHQLMTP MMSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS 101.92 gnl|BL_ORD_ID|443|hsp_num:0 276 Z1_01044 Colistin resistance protein EmrA Loose 730 115.9 farA 26.11 3003961 protein homolog model n/a n/a antibacterial free fatty acids antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MENIQSKKEKIMQLVMVYTPWITVICVVAFIGIATADWDRWWSDARYQTTDNAYIKADSTILKSRMTGFISQINKEDYQVVKRGEVIAEINKKEQILNRQAALAEYQKAQLALDNLTEEIKEYQLNIEKLANRYQASVIDVTQAKRSPMLRKDLINSGAITQQNYLDAQSDLQRLMKLQSAAKNEWDQAKQALVLLKSQEKIRLAQKDIAQTQYQQAETELSYATIKAPFDAQLNKIKVNIGSLVTAGSEIVTLTPINDVYIIANLKETQIKKVQPEQSVAIKVDAFPTDVFSGKVRYIGAQSSGESALIPADNASGNFTKVVQRIPVYITLNSDNRHLAKLRAGMSVQVKIDTESLPVEEGERSD MDTHTDETKLQNTQAKRKRRLTALTLLFALAAAAAGSAFFLWWQHEEETEDAYVAGRVVQVTPQKGGTVRKVLHDDTDAVKKGDVLAVLDDDNDVLAYERAKNELVQAVRQNRRQNAATSQAGAQVALRRADLARAQDDLRRRSALAESGAVSAEELAHARAAVSQAQAAVKAALAEESSARAALGGQVSLREQPAVQTAIGRLKDAWLNLQRTQIRAPADGQVAKRSVQVGQQVAAGAPLMAVVPLSDVWVDANFKETQLRHMKIGQPAELVSDLYGKQIVYRGRVAGFSAGTGSAFSLIPAQNATGNWIKVVQRVPVRIVLNREDVDRHPLRIGLSMTVKVDTSAAGAPVSKTPGAALPEMESTDWSEVDRTVDEILGQSAP 95.31 gnl|BL_ORD_ID|2197|hsp_num:0 2428 Z1_01045 Fatty acid resistance protein FarB Loose 900 53.5 lmrB 22.06 3002813 protein homolog model n/a n/a lincosamide antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MIKLLSAAQNHRPIFVVMAVFTGAILSTLFVRMFSISLADLRGVFGLDVAQGSWLNVALNIAQLISMTLVPWFMVVYGAEKILISASFILFCCGLAVPIIGQQIGFGGLFIAHFMIGFCIGVYLPMTISLALKSLNPSVWLIVMAAYSLRVSVGMDAGVGISGEFVDILNWRWIYWLSAIFTLVILFFTWWGMPLSPINKALLAQSDWGGMALKCLGLTLLYIGVVQGELLGWWDSGLVVSCLIGSAILMGTFIIRAYIYKQSFGHLNWIKDSNLRLCFIIACLYGFLMLPNSLFIPSFLSVVGGLKPLQIGQVTNLAFFIYLLCSPIAIFLARRLEPRLMMLIGIMIIGGACLIGHQIDYQWRANDFFIVISMQAMGECLLLIGLIASFVTNIKPQEALHLGAYISIARVLMPALAGAIINTYLRISYDTHYDLLRGYIQTGEQKLAGNIAEHYQTTMALVIREAHVASFIDGFDLIMLLVILGALCMSFLKSSPENPVVPRLVK METTAKASQQYKVMPIMISLLLAGFIGMFSETALNIALTDLMKELNITAATVQWLTTGYLLVLGILVPVSGLLLQWFTTRQLFTVSLIFSILGTFIAALAPSFSFLLAARIVQALGTGLLLPLMFNTILVIFPPHKRGAAMGTIGLVIMFAPAIGPTFSGLVLEHLNWHWIFWISLPFLVLALVFGIAYMQNVSETTKPKIDVLSIILSTIGFGGIVFGFSNAGEGSGGWSSPTVIVSLIVGVVGLILFSIRQLTMKQPMMNLRAFKYPMFILGVIMVFICMMVILSSMLLLPMYLQGGLVLTAFASGLVLLPGGILNGFMSPVTGRLFDKYGPKWLVIPGFVIVTVVLWFFSNVTTTSTAVLIIILHTCLMIGISMIMMPAQTNGLNQLPREFYPDGTAIMNTLQQMAGAIGTAVAVSIMAAGQHDYMSTVKNPADPAVIPQALTAGVQHAFVFAMIVAIIGLIGAFFMKRVKVDH 106.08 gnl|BL_ORD_ID|541|hsp_num:0 592 Z1_01066 Selenocysteine-specific elongation factor Loose 700 125.6 Planobispora rosea EF-Tu mutants conferring resistance to inhibitor GE2270A 28.17 3003361 protein variant model G279A R234F:2158 elfamycin antibiotic antibiotic target alteration elfamycin resistant EF-Tu MIFATAGHVDHGKTTLIQAITGVDTTHLPEEKKRGMTIDLGYAYWPQTDGSVIGFVDVPGHEKFLSNMLAGIGGISHALLIVACDDGVMAQTIEHTAILRLAGCPNITVILTKADRVEPPRIDEVKQQITTHLLNLGWSAPQIFVTSASTGVGIAQLRDYLVTLHQQEQQHPQWHKRFRLAIDRVFSIKGAGLVVTGTALAGQIALGDTFWLTGADKPVRIRALHAQNQPVEQAGAGMRIAINISGDVSKETVSRGDWLLSQAPLYPSHKILVSLTADEPIKHWQPVHIHHGTRHITGRIALLNNTDETPLLAELILDEPLWLVDNDRLILRDISAQRTLAAAKVLCLHSPRRGKRQAEFLSWLSALDKANTVSDNLALYLPKGELLLTQFAWAQQLTETALDTLLTTFDVISISGVVISKANAEQAKAKLLRTLEEYHQQHNDQMGVGRSRLKRMALPTYHDELVYHLIDQLRQEGAIKQTRGWLHLPTHGLAFSAEQEALWQIAKNYFQQSEPWWVRDLAHEMKHDEKVIRSLLRKAAQLGLIIPIIADRYYTHDSIEKFAAIIVKYNETNGSVTAADFRDELAVGRKLAVQILEYFDRTGFTRRKKDLHILRDKGLF MAKAKFERTKPHMNIGTIGHIDHGKTTLTAAITKVLHDRYPELNKATPFDKIDKAPEEKARGITISIAHVEYQTEKRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATAGPMPQTKEHVLLARQVGVPYIVVALNKADMVDDEEILELVELEVRELLSAQEFPGDDLPVVRVSALKALEGDEKWADSIIELMNAVDENIPEPPRDTDKPFLMPIEDVFSITGRGTVVTGRIERGVVKVNEQVDIIGIKSEKTTTTVTSIEMFNKMLDEGHAGDNAALLLRGIKREQVERGQCIIKPGTTTPHTEFEAQVYILSKDEGGRHTPFFNNYRPQFYFRTTDVTGVVNLPEGTEMVMPGDNTEMTVQLIQPIAMEEGLKFAIREGGRTVGAGRVTKILK 156.17 gnl|BL_ORD_ID|2045|hsp_num:0 2257 Z1_01079 HTH-type transcriptional regulator BenM Loose 550 47.4 NmcR 41.67 3003665 protein homolog model n/a n/a carbapenem; cephalosporin; cephamycin; penam antibiotic inactivation NmcA beta-lactamase MDTRLLNAFVVLADTGHFGEASKQLCISQPALTKQIKTLESQLDIVLFERGRHGAKLTQEGQYLLNQAQVVLRESHILEKQARQLVEPQKVSLYAGFGLSSLSFITSLLARFNQIEPNISVNIDDMSSHKMEEKLLMGELDVAFSRLPVMPPLQGIALTQEQLMLAIATQHITVLEADYNPLHYFDSLGLILLAPEKGKKLYQQIHAFLQQHKLAPRLLQQSQDIQTQLALVAAGLGIALVPKSAQLICDKQRVTLLPLSGLYTQWKIGVIWNSNIKNKERDLFIKIITEKIDIK MRARLPLNALRAFEASARYLNFTKAGLELHVSQAAVSQQVRTLEQMLGVALFTRVPRGLQLTDEGMHLLPSITEALQMMSSAMDKFHEGKIKEVLTIAVVGTFAIGWLLPRITAFLNENPWIDIRILTHNNVVNLAAEGIDASIRFGTGGWINTENILLFQAPHTVLCSPETSKKLYIPSDLKKVCLLRSYRKEEWNNWFKAAGIDPWTITGPIFDSTRLMIDAVKLGDYAALVPYHMFQKELNERSVAKPFEIYATLGGYWLTLQKSRVNHNSEALNVFKEWIIEHSREFVLKS 100.00 gnl|BL_ORD_ID|1908|hsp_num:0 2072 Z1_01093 Dihydropteroate synthase Perfect 500 548.9 sul1 100.0 3000410 protein homolog model n/a n/a sulfonamide antibiotic antibiotic target replacement sulfonamide resistant sul MVTVFGILNLTEDSFFDESRRLDPAGAVTAAIEMLRVGSDVVDVGPAASHPDARPVSPADEIRRIAPLLDALSDQMHRVSIDSFQPETQRYALKRGVGYLNDIQGFPDPALYPDIAEADCRLVVMHSAQRDGIATRTGHLRPEDALDEIVRFFEARVSALRRSGVAADRLILDPGMGFFLSPAPETSLHVLSNLQKLKSALGLPLLVSVSRKSFLGATVGLPVKDLGPASLAAELHAIGNGADYVRTHAPGDLRSAITFSETLAKFRSRDARDRGLDHA MVTVFGILNLTEDSFFDESRRLDPAGAVTAAIEMLRVGSDVVDVGPAASHPDARPVSPADEIRRIAPLLDALSDQMHRVSIDSFQPETQRYALKRGVGYLNDIQGFPDPALYPDIAEADCRLVVMHSAQRDGIATRTGHLRPEDALDEIVRFFEARVSALRRSGVAADRLILDPGMGFFLSPAPETSLHVLSNLQKLKSALGLPLLVSVSRKSFLGATVGLPVKDLGPASLAAELHAIGNGADYVRTHAPGDLRSAITFSETLAKFRSRDARDRGLDHA 100.00 gnl|BL_ORD_ID|982|hsp_num:0 1070 Z1_01094 Multidrug transporter EmrE Perfect 190 224.2 qacEdelta1 100.0 3005010 protein homolog model n/a n/a disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MKGWLFLVIAIVGEVIATSALKSSEGFTKLAPSAVVIIGYGIAFYFLSLVLKSIPVGVAYAVWSGLGVVIITAIAWLLHGQKLDAWGFVGMGLIIAAFLLARSPSWKSLRRPTPW MKGWLFLVIAIVGEVIATSALKSSEGFTKLAPSAVVIIGYGIAFYFLSLVLKSIPVGVAYAVWSGLGVVIITAIAWLLHGQKLDAWGFVGMGLIIAAFLLARSPSWKSLRRPTPW 100.00 gnl|BL_ORD_ID|2753|hsp_num:0 3755 Z1_01095 Streptomycin 3''-adenylyltransferase Perfect 450 526.9 aadA5 100.0 3002605 protein homolog model n/a n/a aminoglycoside antibiotic antibiotic inactivation ANT(3'') MGEFFPAQVFKQLSHARAVIERHLAATLDTIHLFGSAIDGGLKPDSDIDLLVTVSAAPNDSLRQALMLDLLKVSSPPGDGGTWRPLELTVVARSEVVPWRYPARRELQFGEWLRHDILSGTFEPAVLDHDLAILLTKARQHSLALLGPSAATFFEPVPKEHFSKALFDTIAQWNAESDWKGDERNVVLALARIWYSASTGLIAPKDVAAAWVSERLPAEHRPLICKARAAYLGSEDDDLAMRVEETAAFVRYAKATIERILR MGEFFPAQVFKQLSHARAVIERHLAATLDTIHLFGSAIDGGLKPDSDIDLLVTVSAAPNDSLRQALMLDLLKVSSPPGDGGTWRPLELTVVARSEVVPWRYPARRELQFGEWLRHDILSGTFEPAVLDHDLAILLTKARQHSLALLGPSAATFFEPVPKEHFSKALFDTIAQWNAESDWKGDERNVVLALARIWYSASTGLIAPKDVAAAWVSERLPAEHRPLICKARAAYLGSEDDDLAMRVEETAAFVRYAKATIERILR 100.00 gnl|BL_ORD_ID|1305|hsp_num:0 1420 Z1_01096 hypothetical protein Strict 300 315.8 dfrA17 99.36 3002860 protein homolog model n/a n/a diaminopyrimidine antibiotic antibiotic target replacement trimethoprim resistant dihydrofolate reductase dfr MPRASKQQARYAVGRCLMLWSSNDVTQQGSRPKTKLAIKGVKLKISLISAVSENGVIGSGPDIPWSVKGEQLLFKALTYNQWLLVGRKTFDSMGVLPNRKYAVVSKNGISSSNENVLVFPSIENALKELSKVTDHVYVSGGGQIYNSLIEKADIIHLSTVHVEVEGDIKFPIMPENFNLVFEQFFMSNINYTYQIWKKG MKISLISAVSENGVIGSGPDIPWSVKGEQLLFKALTYNQWLLVGRKTFDSMGVLPNRKYAVVSKNGISSSNENVLVFPSIENALKELSKVTDHVYVSGGGQIYNSLIEKADIIHLSTVHVEVEGDIKFPIMPENFNLVFEQFFMSNINYTYQIWKKG 126.75 gnl|BL_ORD_ID|1053|hsp_num:0 1142 Z1_01103 Chloramphenicol acetyltransferase Perfect 400 469.9 catI 100.0 3002683 protein homolog model n/a n/a phenicol antibiotic antibiotic inactivation chloramphenicol acetyltransferase (CAT) MEKKITGYTTVDISQWHRKEHFEAFQSVAQCTYNQTVQLDITAFLKTVKKNKHKFYPAFIHILARLMNAHPEFRMAMKDGELVIWDSVHPCYTVFHEQTETFSSLWSEYHDDFRQFLHIYSQDVACYGENLAYFPKGFIENMFFVSANPWVSFTSFDLNVANMDNFFAPVFTMGKYYTQGDKVLMPLAIQVHHAVCDGFHVGRMLNELQQYCDEWQGGA MEKKITGYTTVDISQWHRKEHFEAFQSVAQCTYNQTVQLDITAFLKTVKKNKHKFYPAFIHILARLMNAHPEFRMAMKDGELVIWDSVHPCYTVFHEQTETFSSLWSEYHDDFRQFLHIYSQDVACYGENLAYFPKGFIENMFFVSANPWVSFTSFDLNVANMDNFFAPVFTMGKYYTQGDKVLMPLAIQVHHAVCDGFHVGRMLNELQQYCDEWQGGA 100.00 gnl|BL_ORD_ID|702|hsp_num:0 763 Z1_01104 Tetracycline resistance protein, class C Strict 700 800.0 tet(A) 100.0 3000165 protein homolog model n/a n/a tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MSTNLSVIKNPRVQSDQRRLVRRPDVKPNRPLIVILSTVALDAVGIGLIMPVLPGLLRDLVHSNDVTAHYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYAIMATAPFLWVLYIGRIVAGITGATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLMGGFSPHAPFFAAAALNGLNFLTGCFLLPESHKGERRPLRREALNPLASFRWARGMTVVAALMAVFFIMQLVGQVPAALWVIFGEDRFHWDATTIGISLAAFGILHSLAQAMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWMAFPIMVLLASGGIGMPALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLFTAIYAASITTWNGWAWIAGAALYLLCLPALRRGLWSGAGQRADR MSTNLSVIKNPRVQSDQRRLVRRPDVKPNRPLIVILSTVALDAVGIGLIMPVLPGLLRDLVHSNDVTAHYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYAIMATAPFLWVLYIGRIVAGITGATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLMGGFSPHAPFFAAAALNGLNFLTGCFLLPESHKGERRPLRREALNPLASFRWARGMTVVAALMAVFFIMQLVGQVPAALWVIFGEDRFHWDATTIGISLAAFGILHSLAQAMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWMAFPIMVLLASGGIGMPALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLFTAIYAASITTWNGWAWIAGAALYLLCLPALRRGLWRNSSNSRCT 100.00 gnl|BL_ORD_ID|1795|hsp_num:0 1808 Z1_01106 hypothetical protein Loose 290 62.8 golS 29.13 3000504 protein homolog model n/a n/a monobactam; carbapenem; cephalosporin; cephamycin; penam; phenicol antibiotic; penem antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MQEWRPARRRRAHRARFVVQTYVGPFEFGLDSVTLLPYSCTESSDMENNLENLTIGVFAKAAGVNVETIRFYQRKGLLREPDKPYGSIRRYGEADVVRVKFVKSAQRLGFSLDEIAELLRLDDGTHCEEASSLAEHKLKDVREKMADLARMETVLSELVCACHARKGNVSCPLIASLQGEAGLARSAMP MNIGKAAKASKVSAKMIRYYEQIGLIPAASRTDSGYRAYTQADVNQLHFIRRARDLGFSVAEISDLLNLWNNQSRQSADVKRLAQTHIDELDRRIQNMQHMAQTLKALIHCCAGDALPDCPILHTLGQPDDSEPEARTGAVLRRPRRHGLAKRL 122.73 gnl|BL_ORD_ID|36|hsp_num:0 44 Z1_01114 hypothetical protein Strict 500 562.8 APH(6)-Id 99.64 3002660 protein homolog model n/a n/a aminoglycoside antibiotic antibiotic inactivation APH(6) MFMPPVFPAHWHVSQPVLIADTFSSLVWKVSLPDGTPAIVKGLKPIEDIADELRGADYLVWRNGRGAVRLLGRENNLMLLEYAGERMLSHIVAEHGDYQATEIAAELMAKLYAASEEPLPSALLPIRDRFAALFQRARDDQNAGCQTDYVHAAIIADQMMSNASELRGLHGDLHHENIMFSSRGWLVIDPVGLVGEVGFGAANMFYDPADRDDLCLDPRRIAQMADAFSRALDVDPRRLLDQAYAYGCLSAAWNADGEEEQRDLAIAAAIKQVRQTSY MFMPPVFPAHWHVSQPVLIADTFSSLVWKVSLPDGTPAIVKGLKPIEDIADELRGADYLVWRNGRGAVRLLGRENNLMLLEYAGERMLSHIVAEHGDYQATEIAAELMAKLYAASEEPLPSALLPIRDRFAALFQRARDDQNAGCQTDYVHAAIIADQMMSNASELRGLHGDLHHENIMFSSRGWLVIDPVGLVGEVGFGAANMFYDPADRDDLCLDPRRIAQMADAFSRALDVDPRRLLDQAYAYGCLSAAWNADGEQEQRDLAIAAAIKQVRQTSY 100.00 gnl|BL_ORD_ID|953|hsp_num:0 1031 Z1_01115 Aminoglycoside 3'-phosphotransferase Strict 500 553.1 APH(3'')-Ib 99.63 3002639 protein homolog model n/a n/a aminoglycoside antibiotic antibiotic inactivation APH(3'') MNRTNIFFGESHSDWLPVRGGESGDFVFRRGDGHAFAKIAPASRRGELAGERDRLIWLKGRGVACPEVINWQEEQEGACLVITAIPGVPAADLSGADLLKAWPSMGQQLGAVHSLSVDQCPFERRLSRMFGRAVDVVSRNAVNPDFLPDEDKSTPQLDLLARVERELPVRLDQERTDMVVCHGDPCMPNFMVDPKTLQCTGLIDLGRLGTADRYADLALMIANAEENWAAPDEAERAFAVLFNVLGIEAPDRERLAFYLRLDPLTWG MNRTNIFFGESHSDWLPVRGGESGDFVFRRGDGHAFAKIAPASRRGELAGERDRLIWLKGRGVACPEVINWQEEQEGACLVITAIPGVPAADLSGADLLKAWPSMGQQLGAVHSLLVDQCPFERRLSRMFGRAVDVVSRNAVNPDFLPDEDKSTPQLDLLARVERELPVRLDQERTDMVVCHGDPCMPNFMVDPKTLQCTGLIDLGRLGTADRYADLALMIANAEENWAAPDEAERAFAVLFNVLGIEAPDRERLAFYLRLDPLTWG 100.00 gnl|BL_ORD_ID|1693|hsp_num:0 1830 Z1_01116 Dihydropteroate synthase Strict 500 515.0 sul2 99.63 3000412 protein homolog model n/a n/a sulfonamide antibiotic antibiotic target replacement sulfonamide resistant sul MNKSLIIFGIVNITSDSFSDGGRYLAPDAAIAQARKLMAEGADVIDLGPASSNPDAAPVSSDTEIERIAPVLDALKADGIPVSLDSYQPATQAYALSRGVAYLNDIRGFPDAAFYPQLAKSSAKLVVMHSVQDGQADRREAPAGDIMDHIAAFFDARIAALTGAGIKRNRLVLDPGMGFFLGAAPETSLSVLARFDELRLRFDLPVLLSVSRKSFLRALTGRGPGDVGAATLAAELAAAAGGADFIRTHEPRPLRDGLAVLAALKETARIR MNKSLIIFGIVNITSDSFSDGGRYLAPDAAIAQARKLMAEGADVIDLGPASSNPDAAPVSSDTEIARIAPVLDALKADGIPVSLDSYQPATQAYALSRGVAYLNDIRGFPDAAFYPQLAKSSAKLVVMHSVQDGQADRREAPAGDIMDHIAAFFDARIAALTGAGIKRNRLVLDPGMGFFLGAAPETSLSVLARFDELRLRFDLPVLLSVSRKSFLRALTGRGPGDVGAATLAAELAAAAGGADFIRTHEPRPLRDGLAVLAALKETARIR 100.00 gnl|BL_ORD_ID|877|hsp_num:0 952 Z1_01119 Beta-lactamase TEM Perfect 500 570.9 TEM-1 100.0 3000873 protein homolog model n/a n/a monobactam; cephalosporin; penam; penem antibiotic inactivation TEM beta-lactamase MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 100.00 gnl|BL_ORD_ID|325|hsp_num:0 355 Z1_01169 Methyl viologen resistance protein SmvA Loose 600 294.7 Acinetobacter baumannii AmvA 38.95 3004577 protein homolog model n/a n/a macrolide antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MIKDYKRWIVLLLVSSMLFLIVVDVTVLYTALPRLTHDLNASASEKLWIMNAYPLIVAGLLPAAGMLTDRIGHKTLFISGLPLFAIASLCAAYSPSATSLIISRGFLAVGAAMSMPATLSIVRQVFTHPQERAVAIGIWSAVASGGAALGPLIGGLLLNHFWWGSVFLINVPIVLLVLPFSIWLIPHFSGQRQHKIDYLSSILILIGLVSAIYTLKEIGKAYTQWNEVIIATLIAIIFLTLFARRQRRQTHPMIDFSLFKKRYFSVGVAMSTLSMVIIVGIEFLLSQRLQLVAGFTPLNAALVILPIPIGSVLASPLAGFWLARLGAVRLIIIGFALTLMGNLWLIAISNSPIMLMGSLFLIGFGLGIIFTTASTSIMLSVDDKQAGMAASIEDIAYELGSVIGVTFMGSLMSTLYTLKLTLPNTLNVNSVVYDSLDEALIVAEKLPEAAATLLIAQANSAFEYAFSIVLIATAIVTTISLIALPYCLRNAVRENKPSH MQKKWLILTIIVLIYLPVTIDATVMHVATPSLSAALNLTANQLLWIIDIYSLIMAGLILPMGALGDRIGFKKLLFIGTAVFGVGSLAAAFSPTAYALIASRAILGLGAAMLIPATLSGIRNAFTEEKQRNFALGIWSTVGGGGAAFGPLVGGFVLEHFHWGAVFLINIPIILAVLVMIVMIIPKQQEKTDQPINLGQALVLVVAILSLIYSIKSAMYNFSVLTVVMFVVGISTLIHFIRSQKRATTPMIDLELFKHPVISTSIVMAVVSMIALVGFELLLSQELQFVHGFSPLQAAMFIIPFMIAISLGGPLAGICLNKWGLRRVSSLGILVSALSLWGLAQLNFSTDHFLAWTCMVFLGFSIEIALLASTAAIMSSVPPQKASAAGAIEGMAYELGAGLGVAIFGLMLSWFYSRSIILPAELPSNLIEKASISIGETMQLASNLENPLGGQLIVVAQQAFSYAHSWVLTLSAICFFLLTVFVWFSFPKKVN 101.42 gnl|BL_ORD_ID|2727|hsp_num:0 3280 Z1_01171 Petrobactin import ATP-binding protein YclP Loose 500 107.1 RanA 27.39 3005091 protein homolog model n/a n/a aminoglycoside antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MIEISKISKRYQDTTVLDNITTTIQRGGITSIIGPNGAGKSTLLSVIGRLLMPESGMVSVNGMDVAATESDVLAKNLSILRQENQFVSRLTVEELVGFGRYPYSKGRLTLEDKKVIDESLDFLNLTEFRHRYLDELSGGQRQRTYVAMVLCQDTEYVMLDEPLNNLDMKHAVIMMKLLRKAADELGKTIIIVIHDINFASVYSDYILAMRNGQLYYHGSPKEIMKSDIIEDIFDTPVDVKELDDKLIAMYY MIEVKDLRKSFNDVEVLKGITTTFETGKINLVIGQSGSGKTVFLKCLLNVFDPSSGDILFDGRNLSIMGRTEKQEIRSEIGTVFQGSALFDSMTVEENISFPLDMFTNLTYTEKRKRVKEVIGRVHLENANTKFPSEISGGMQKRVAIARAIVNNPKYLFCDEPNSGLDPNTAIVIDELIKEITEEYNTTTIINTHDMNSVLTIGEKIVYLRKGVKEWEGNKDLIIKAENEHLIDFVYSSALFKQVRETMLRNNQTNL 97.29 gnl|BL_ORD_ID|2817|hsp_num:0 3825 Z1_01187 Metal-staphylopine import system ATP-binding protein CntD Loose 500 81.3 RanA 26.39 3005091 protein homolog model n/a n/a aminoglycoside antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MNNLLTLNQVSIYDPHSEKKRVDNLSFSLKQGRTLAIVGESGSGKSLISKAIIGLLPSTLALSGEIFFDEKPLHLYSEQQRRALLGTSLGMIVQNGMSAFDPLIKIGKQVSQTLIYHFSYTKLQAFNATKQALDEVFEHQSLMIMQAFPHQLSGGQLQRVMIAMALALSPRLLIADEPTTALDAPLRREILQLLQRITISKNTTLIFISHDLGLVSQIADDILVMKEGKLIEFGDKNSVLDTPKQAYTRYLIEARAKLSQRFAQVLYAR MIEVKDLRKSFNDVEVLKGITTTFETGKINLVIGQSGSGKTVFLKCLLNVFDPSSGDILFDGRNLSIMGRTEKQEIRSEIGTVFQGSALFDSMTVEENISFPLDMFTNLTYTEKRKRVKEVIGRVHLENANTKFPSEISGGMQKRVAIARAIVNNPKYLFCDEPNSGLDPNTAIVIDELIKEITEEYNTTTIINTHDMNSVLTIGEKIVYLRKGVKEWEGNKDLIIKAENEHLIDFVYSSALFKQVRETMLRNNQTNL 104.26 gnl|BL_ORD_ID|2817|hsp_num:0 3825 Z1_01188 Metal-staphylopine import system ATP-binding protein CntF Loose 300 73.2 poxtA 29.6 3004470 protein homolog model n/a n/a tetracycline antibiotic; oxazolidinone antibiotic; phenicol antibiotic antibiotic target protection Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins MLLRVDNVSKYYYQKGARFFKEKVTILDALSFNIQKGEAFGLVGESGSGKSTLARLISGLELPDQGAIYLNDKPVTKRCYRQGVISIVFQDHIASVNPTFTVGEMIAEPIKLINPTLRHNELETIIFSFLEKVQLPKSCYQRYIFELSGGQAQRVCLCRALASYPQLIILDEAISSLDIPTQVEILDLLKLLKEELQLSYLFISHDIQTVTYFCDKVMFILQGQQIELCEINKLSTVTHPYAKKLIQSVI MKGKNMNLAFGLEEIYEDAEFQIGDLDKVGIVGVNGAGKTTLFRLLLGELELDNGSLTSGNARIGYLPQEIVLEDEDITVWDFLFEGRPIKKYEQELEEIYKKLETAVNAEQEALLARMGTLQERLEYFDFYEAETILLEFADKMSIDAELYHRPMRELSGGQKSKMAFARLLYSKPEILLLDEPTNHLDVSTKDFVIKYLKNYRGSVLIISHDIDFLNRIINKIMYINKATHKISVYDGDYYIYKKKYAEEQRIREMAIVQQEKEIKELSDFVQKAKQASQTNHHLKRMGQERALRLDKKRGELQKRNRLYKRVKMDIRPKREGAQVPLEVENITFHYSGYPTLYQNLSFQINGRERFLVVGENGVGKSTLLKLMMGILSPDEGCIRFNQKTDIAYYAQELEQLDENKTVIDNVESEGYTPWQIRAVLSNFLFYDDDVNKKVSVLSPGEKARVALCKILLQKANLLILDEPTNHLDPETQKIIGGNFNLFEGTIIAVSHNPSFVEQIGISRMLILPSGRIEPYSRELLEYYYEINGSVAKF 46.13 gnl|BL_ORD_ID|2519|hsp_num:0 2904 Z1_01235 Phosphate import ATP-binding protein PstB Loose 500 111.3 RanA 30.52 3005091 protein homolog model n/a n/a aminoglycoside antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MTMANDNAGNKIQVRDLNFYYGKFHALKNISLDIAKNKVTAFIGPSGCGKSTLLRTFNKMYELYGEQRAEGEILLDGNNILTDKQDIALLRAKVGMVFQKPTPFPMSIYDNIAFGVRLFEKLSRAEMDERVQWALTKAALWNETKDKLHQSGYSLSGGQQQRLCIARGIAIRPEVLLLDEPCSALDPISTGRIEELISELKSEYTVVIVTHNMQQAARCSDYTAFMYLGELIEFSDTDTLFTRPAKKQTEDYITGRYG MIEVKDLRKSFNDVEVLKGITTTFETGKINLVIGQSGSGKTVFLKCLLNVFDPSSGDILFDGRNLSIMGRTEKQEIRSEIGTVFQGSALFDSMTVEENISFPLDMFTNLTYTEKRKRVKEVIGRVHLENANTKFPSEISGGMQKRVAIARAIVNNPKYLFCDEPNSGLDPNTAIVIDELIKEITEEYNTTTIINTHDMNSVLTIGEKIVYLRKGVKEWEGNKDLIIKAENEHLIDFVYSSALFKQVRETMLRNNQTNL 100.00 gnl|BL_ORD_ID|2817|hsp_num:0 3825 Z1_01239 Osmolarity sensor protein EnvZ Loose 890 124.0 cpxA 28.21 3000830 protein homolog model n/a n/a aminoglycoside antibiotic; aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MRRLRLSPHNKLTRSLFLVILLLFFSLIASYVVVQHLIVGPSLQQFNKVLAYEIRTLVPEELILVDGTPLKISPALRNKIYNELGISFFDKDAALKAGLEWAREDLELSQQMTDYLNSDTTIWLENTLEYPILWINTQLSPTLWIRVPLTELGQNFLLPVYRQAIIFIIIVVAFFWLYNRFQNRPLHEVEYAARRIGKGVIPPPIPESGTAEMRSIIRAFNQMSSDIRSLDNDRTLVMAGVSHDLRTPLTRIRLATEMMSPEDSYLADSINKDIEDCDAIIGQFLDYMRTGKEMSLELCDMNGLLREVICAESNSGKVSEEHLYPYPINITANPIAVKRALTNMIVNATRYGHGWISITSNQNEEYAWFQVEDDGPGIAKEDRQRLFQPFVQGEQARSSTGAGLGLSIIRRIMDAHGGFVELGDSTKGGLLIRANFPLKVQEDEDD MIGSLTARIFAIFWLTLALVLMLVLMLPKLDSRQMTELLDSEQRQGLMIEQHVEAELANDPPNDLMWWRRLFRAIDKWAPPGQRLLLVTTEGRVIGAERSEMQIIRNFIGQADNADHPQKKKYGRVELVGPFSVRDGEDNYQLYLIRPASSSQSDFINLLFDRPLLLLIVTMLVSTPLLLWLAWSLAKPARKLKNAADEVAQGNLRQHPELEAGPQEFLAAGASFNQMVTALERMMTSQQRLLSDISHELRTPLTRLQLGTALLRRRSGESKELERIETEAQRLDSMINDLLVMSRNQQKNALVSETIKANQLWSEVLDNAAFEAEQMGKSLTVNFPPGPWPLYGNPNALESALENIVRNALRYSHTKIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAIVETAIQQHRGWVKAEDSPLGGLRLVIWLPLYKRS 97.59 gnl|BL_ORD_ID|132|hsp_num:0 152 Z1_01240 Transcriptional regulatory protein OmpR Loose 400 181.4 ParR 41.56 3005068 protein homolog model n/a n/a macrolide antibiotic; fluoroquinolone antibiotic; monobactam; aminoglycoside antibiotic; carbapenem; cephalosporin; cephamycin; penam; tetracycline antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics antibiotic efflux; reduced permeability to antibiotic resistance-nodulation-cell division (RND) antibiotic efflux pump; Outer Membrane Porin (Opr) MQDSYKVLIVDDDLRLRSLLERYLTEQGFQIRTAANSDQMDRLLTRESIHLIVLDLMLPGEDGLSICRRLRSQNNPIPIIMVTAKGEEVDRIVGLEIGADDYISKPFNPRELLARIRAVLRRQANELPGAPSQDNAIVSFGKFKLNLGTREMFHEDQHMPLTSGEFAVLKVLVSHPREPLSRDKLMSLARGREYSAMERSIDVQISRLRRMIEEDPTHPRYIQTVWGLGYVFVPDGTSVS MDCPTLSKVLLVEDDQKLARLIASFLSQHGFEVRQVHRGDAAFAAFLDFKPQVVVLDLMLPGQNGLQVCREIRRVANLPILILTAQEDDLDHILGLESGADDYVIKPIEPPVLLARLRALMRRHAPLPASPESLTFGKLNIDRRRREAELEGLGIELTTMEFELLWLLASQAGEILSRDEILNQIRGIGFDGLNRSVDVCISKLRNKLKDNPREPVRIKTVWGKGYLFNPLGWEL 102.13 gnl|BL_ORD_ID|2800|hsp_num:0 3806 Z1_01247 DNA-binding transcriptional regulator NtrC Loose 400 193.0 TxR 35.15 3005008 protein homolog model n/a n/a tetracycline antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MQKGNIWVVDDDSSIRWVLERAITREGLTCKTFEHANDVLSALNSELPDVLLSDIRMPDIDGLSLLKSVKEQHPTLPVIIMTAHSDLDAAVNAYQQGAFDYLPKPFDIDDTLALIHRAITHYREQKQPNTTETNLQSVSDMIGEAPAMQEVYRIIGRLSRSSISVLINGESGTGKELVAHALHRHSPRAQAPFIALNMAAIPKDLIESELFGHEKGAFTGASQVRQGRFEQANGGSLFLDEIGDMPLDIQTRLLRVLAEGQFYRVGGYAPVKVDVRIIAATHQDLEKRVMEGDFREDLYHRLNVIRIQLPPLRDRTEDIPSLARYFLQKTARELGVETKVLHQQSLHCMMEYHWSGNVRQLENVCRWLTVMTASQEIMPQDLPQEIRQSDEKGKSIPRISSQHWSQHLSLWADEVFSEGKENILNDALPQFERTLLLSALSYTKGHKQDAARLLGWGRNTLTRKLKELGIEEF MKVQKCKATIHRRSLDADPLLPLIGNSTCISELRNKLKKYAQCDAEVLIQGETGVGKGMCARIIHELSSRHIYPFVEVNCGAIPSGLIASELFGHEKGAFTGAISDRIGFIQKANKGTLFLDEIGDMPPDLQIHLLHFLESKQIHKVGADKIIDVDCRVIAASHVDLKSEVIQGGFREDLFYRQNILPLTIPPLRKRGEDTVILSERFLEELSNGKVQSMSPEVKKKLLKHKWPGNVRELRNVIQRAIVMCEDNTLHIADLGLDNNERQLLPSVEQIDLDYLLKAIEDNKHNMSAAARNLGISRTTLYRLIKKYNLPI 148.74 gnl|BL_ORD_ID|4730|hsp_num:0 3753 Z1_01248 Sensory histidine kinase/phosphatase NtrB Loose 880 64.7 arlS 29.73 3000839 protein homolog model n/a n/a fluoroquinolone antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump METADLPDNTLILDSLIHSVLVINQEFIICYANHAALQLLAQSRRKLFETPFSALFSYSSFDEQLMRETLANGQSFTDNEVILVINNQSHTMSLSAQPISEQHILLELAPMDSQRRLSQEQIQQAQQMAARELVRGLAHEIKNPLGGLRGAAQLLAKSLPDPALTEYTQVIIEQADRLRALVDRLLGPQHPGTKTFQSIHHVVERVAQLITLECPENVTLLKDYDPSLPELSHYPDQIEQVLLNITRNALQAVEKTGGTIILRTRTAFQVTLQGERHRLVARIDVIDTGAGIPPHLQDTLFYPMVSGREGGNGLGLSIARSLVDQHAGKIEFTSWPGNTEFSIYLPIK MTKRKLRNNWIIVTTMITFVTIFLFCLIIIFFLKDTLHNSELDDAERSSSDINNLFHSKPVKDISALDLNASLGNFQEIIIYDEHNNKLFETSNDNTVRVEPGYEHRYFDRVIKKRYKGIEYLIIKEPITTQDFKGYSLLIHSLENYDNIVKSLYIIALAFGVIATIITATISYVFSTQITKPLVSLSNKMIEIRRDGFQNKLQLNTNYEEIDNLANTFNEMMSQIEESFNQQRQFVEDASHELRTPLQIIQGHLNLIQRWGKKDPAVLEESLNISIEEMNRIIKLVEELLELTKGDVNDISSEAQTVHINDEIRSRIHSLKQLHPDYQFDTDLTSKNLEIKMKPHQFEQLFLIFIDNAIKYDVKNKKIKVKTRLKNKQKIIEITDHGIGIPEEDQDFIFDRFYRVDKSRSRSQGGNGLGLSIAQKIIQLNGGSIKIKSEINKGTTFKIIF 77.16 gnl|BL_ORD_ID|166|hsp_num:0 182 Z1_01250 GTP-binding protein TypA/BipA Loose 275 121.3 Streptomyces rimosus otr(A) 40.69 3002891 protein homolog model n/a n/a tetracycline antibiotic antibiotic target protection tetracycline-resistant ribosomal protection protein MIENLRNIAIIAHVDHGKTTIVDKLLQQSGTFGERETVAERVMDSNDLERERGITILAKNTAIKWNDYRINIVDTPGHADFGGEVERVMSMVDSVLLLVDAMDGPMPQTRFVTQKAFANNLKPIVVINKVDRPGARPDWVVDQVFDLFVNLGATDEQLDFPIIYASALNGIAGTDYNDMADDMTPLYEAIVKYVEPPKVDLEGTFQMQISQLDYNNYLGVIGIGRIKRGKVKPNQQVTIIDSEGNTRNGKVGKVLGHLGLERIDVDVAEAGDIIAITGLGELNISDTICEVGAVEALPALAVDEPTVSMYFCVNTSPFCGREGKFVTSRQILDRLKKELVHNVALRVEETEDPDAFRVSGRGELHLSVLIENMRREGYELAVSRPKVIFREIDGRKQEPFEQVTIDIEEQHQGDVMQAMGERKGEMRDMQPDGKGRVRLDYIIPSRGLIGFRTEFMTMTSGTGLLYATFSHYDDVRPGEIGRRNNGVMISNGQGKAVAYALYSLQDRGKLFVTHGAEVYEGQVIGIHTRSNDLTVNCLTGKKLTNMRASGTDEATTLTPHIKQTLEQALEFIDDDELVEVTPQSIRLRKRHLSENDRRRAYRSKD MNKLNLGILAHVDAGKTSLTERLLHRTGVIDEVGSVDAGTTTTDSMELERQRGITIRSAVATFVLDDLKVNLIDTPGHSDFISEVERALGVLDGAVLVVSAVEGVQPQTRILMRTLRRLGIPTLVFVNKIDRGGARPDGVLREIRDRLTPAAVALSAVADAGTPRARAIALGPDTDPDFAVRVGELLADHDDAFLTAYLDEEHVLTEKEYAEELAAQTARGLVHPVYFGSALTGEGLDHLVHGIRELLPSVHASQDAPLRATVFKVDRGARGEAVAYLRLVSGTLGTRDSVTLHRVDHTGRVTEHAGRITALRVFEHGSATSETRATAGDIAQAWGLKDVRVGDRAGHLDGPPPRNFFAPPSLETVIRPERPEEAGRLHAALRMLDEQDPSIDLRQDEENAAGAVVRLYGEVQKEILGSTLAESFGVRVRFDPTRTVCIEKPVGTGEALIELDTRTHNYFWGAPWVCASDRPSPARAITFRLAVELGSLPLAFHKAIEETVHTTLRHGLYGWQVTDCAVTLTRTGVRSPVSAADDFRKANARLVLMDALGRAGTEVHEPVSSFELEVPAARLSPVLAKLAELGATPGVPTAEGDVFRLEGTMPTSLVHDFNQRVPGLTQGEGVFLAEHRGYRPAVGQPPVRPRPEGPNPLNRDEYILHVLKRV 91.25 gnl|BL_ORD_ID|4813|hsp_num:0 1273 Z1_01264 tRNA (guanosine(18)-2'-O)-methyltransferase Loose 450 44.7 tsnR 27.21 3003060 protein homolog model n/a n/a peptide antibiotic antibiotic target alteration non-erm 23S ribosomal RNA methyltransferase (A1067) MNPTRYARICQMMAMRQPDLTVCLEEVHKSHNVAAVIRTADAVGIPKIHAIWPEEKMRMLVSPAAGSNSWVNVNTHPTIADAINTFRAQGMQVLATHLSDKAVDFREIDYTQPTCIIMGQEKTGISPEAIALADQDIIVPMMGMVQSLNVSVASALILYEAQRQRQAAGMYNRTESALTAEEQQILLFEGGYPVLAEVSRRKGLPRPYINDRGEIEAPDSWWAEMQMTQKQLRKFKLTE MANLDVIVDRSDPAVQRIVDVTKHSRSVVRTVLIEDIEPLTQSIRAGVEFTEVYGLDTVPFPGDLLAACEKRGIRVRLLSAAVANQVFKTEKKPKVFGIAKVPPAGRFADLESLSGDVVLLDGVKIVGNIGAIVRTRSALGAAGIVLVDSGLGTIADRRLIRASRGYVFSLPIVLATRDEALAFFRDGGMRPVVFEADGKLSIGELDGIDERLVLVFGSEKTGPSGEFAGVATESVSIPMNPAAESLNVSVSAGIALHRRARRNLSRPRG 88.52 gnl|BL_ORD_ID|149|hsp_num:0 49 Z1_01286 Dipeptide transport ATP-binding protein DppD Loose 500 88.6 RanA 26.72 3005091 protein homolog model n/a n/a aminoglycoside antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MALLNINQLSVHFGDEDTPFKAVDRISYQVEEGQVVGIVGESGSGKSVSSLAIMGLIDFPGRVSAQALQFDGRDLMQISESERRDLVGAEVAMIFQDPMTSLNPCFTVGYQIMEALKVHQGGSHRTRKQRAIDLLTLVGIPDPASRLNVYPHQLSGGMSQRVMIAMAIACQPKLLIADEPTTALDVTIQAQIIELLLELQKQENMALVLITHDLALVAEAADTIIVMYAGQVVESGLATEIFKAPRHPYTQALLKALPEFASDKARLESLPGVVPGRYDRPMGCLLNPRCPYAQDTCFQIEPELKEMGKHRVKCHTPLDDTGRPTYG MIEVKDLRKSFNDVEVLKGITTTFETGKINLVIGQSGSGKTVFLKCLLNVFDPSSGDILFDGRNLSIMGRTEKQEIRSEIGTVFQGSALFDSMTVEENISFPLDMFTNLTYTEKRKRVKEVIGRVHLENANTKFPSEISGGMQKRVAIARAIVNNPKYLFCDEPNSGLDPNTAIVIDELIKEITEEYNTTTIINTHDMNSVLTIGEKIVYLRKGVKEWEGNKDLIIKAENEHLIDFVYSSALFKQVRETMLRNNQTNL 126.74 gnl|BL_ORD_ID|2817|hsp_num:0 3825 Z1_01287 Glutathione import ATP-binding protein GsiA Loose 500 96.3 RanA 27.65 3005091 protein homolog model n/a n/a aminoglycoside antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MANVNPNTAVPLLKAVNLAKYYSVKGGLFAKEKTVKALDGVSFELERGKTLAVVGESGCGKSTLGRLLTMIEVPTSGELSYQGQNLLVKDKSAEKLRRQKIQIVFQNPYGSLNPRKKVGQILEEPLLINTTLSAQDRKEKVLSMMAKVGLKAEHYSRYPHMFSGGQRQRIAIARGLMLEPDIVVADEPVSALDVSVRAQVLNLMMDLQQEMGLSYVFISHDLSVVEHIADEVVVMYLGRCVEKGTKAQIFENPQHPYTQALLSATPRLTPTLRRERIKLTGELPSPLNPPPGCAFAARCRRAFGMCTQLQPTLKEYHGQLIACFAVEQDHGEF MIEVKDLRKSFNDVEVLKGITTTFETGKINLVIGQSGSGKTVFLKCLLNVFDPSSGDILFDGRNLSIMGRTEKQEIRSEIGTVFQGSALFDSMTVEENISFPLDMFTNLTYTEKRKRVKEVIGRVHLENANTKFPSEISGGMQKRVAIARAIVNNPKYLFCDEPNSGLDPNTAIVIDELIKEITEEYNTTTIINTHDMNSVLTIGEKIVYLRKGVKEWEGNKDLIIKAENEHLIDFVYSSALFKQVRETMLRNNQTNL 129.07 gnl|BL_ORD_ID|2817|hsp_num:0 3825 Z1_01311 cAMP-activated global transcriptional regulator CRP Strict 400 412.5 CRP 98.1 3000518 protein homolog model n/a n/a macrolide antibiotic; fluoroquinolone antibiotic; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MVLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEDQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMANRLQTTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR MVLGKPQTDPTLEWFLSHCHIHKYPSKSKLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR 100.00 gnl|BL_ORD_ID|804|hsp_num:0 869 Z1_01324 putative ABC transporter ATP-binding protein YheS Loose 1300 300.4 optrA 31.66 3003746 protein homolog model n/a n/a oxazolidinone antibiotic; phenicol antibiotic antibiotic target protection Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins MIVFSSLQIRRGVRVLLDNASATINPGQKIGLVGKNGCGKTTLLSLLKGDLQAEAGNVTFPSTWSMAWVNQETPALDVPAIDYVIDGDREYRELERRLQQANDNNDGHAIALIHGQLDAINAWTIQSRAATLLNGLGFSQQQLTEPVKSFSGGWRMRLNLAQALICRSDLLLLDEPTNHLDLDAVIWLEKWLKSYNGTLILISHDRDFLDPIVDKILHIEQEKIFEYSGNYSSFEMQRATKLAQQQALFENQQAKIAHLQSFIDRFKAKATKAKQAQSRVKMLERMERVAPAHSDNPFQFSFRQPESLPNPLLSMEKVSAGYGDKIILNNIKLNLIPGSRIGLLGRNGAGKSTLIKLLAGELAPLQGKVALSKGIKLGYFAQHQLEYLRADESALQHLTRLAPQETEQKLRDYLGGFGFHGDKVTDACGQFSGGEKARLVLSLLVWQRPNLLLMDEPTNHLDLDMRQALTQTLISFEGAIVVVSHDRHLLRSTTDDLYLVHDGQVEPFEGDLDDYQQWLVDQNRQETQANKTQPDQETTNASNLTAQDKKEQKRKEAEFRQQTQPLRKKLTTLESKMDKLSQELTAIETELSDSQIYEAKNKATLTDCLNRQSIAKSALEEVEMAWMELQEKLEEMTNAFESQ MSKATFAIASTNAKEDMKMQYKIINGAVYYDGNMVLENIGIEINDNEKIAIVGRNGCGKTTLLKAIIGEIELEEGTGESEFQVIKTGNPYISYLRQMPFEDESISMVDEVRTVFKTLIDMENKMKQLIDKMENQYDDKIINEYSDISERYMALGGLTYQKEYETMIRSMGFTEADYKKPISEFSGGQRTKIAFIKILLTKPDILLLDEPTNHLDIETIQWLESYLRSYKSTLVIISHDRMFLNRIVDKVYEIEWGETKCYKGNYSAFEEQKRENHIKQQKDYDLQQIEIERITRLIERFRYKPTKAKMVQSKIKLLQRMQILNAPDQYDTKTYMSKFQPRISSSRQVLSASELVIGYDTPLAKVNFNLERGQKLGIVGSNGIGKSTLLKTLMGGVAALSGDFKFGYNVEISYFDQQLAQISGDDTLFEIFQSEYPELNDTEVRTALGSFQFSGDDVFRPVSSLSGGEKVRLTLCKLLYKRTNVLILDEPTNHMDIIGKENLENILCSYQGTIIFVSHDRYFTNKIADRLLVFDKDGVEFVQSTYGEYEKKRMNSEKPFNNIKVEQKVEKNNTVKGDRNSIEKEKVKKEKRIEKLEVLINQYDEELERLNKIISEPNNSSDYIVLTEIQKSIDDVKRCQGNYFNEWEQLMRELEVM 98.17 gnl|BL_ORD_ID|2074|hsp_num:0 2263 Z1_01338 Elongation factor G Loose 1350 816.6 Staphylococcus aureus fusA with mutation conferring resistance to fusidic acid 58.24 3003735 protein variant model V90I fusidane antibiotic antibiotic target alteration antibiotic resistant fusA MARQTPIARYRNIGISAHIDAGKTTTSERILFYTGVNHKIGETHEGSATMDWMEQEQERGITITSAATTAFWSGMAKQFEPHRVNIIDTPGHVDFTIEVERSMRVLDGAVMVYCAVGGVQPQSETVWRQANKYHVPRIAFVNKMDRMGANFLRVVEQIKTRLAANPVPLQIPVGAEEDFTGVVDLIKMKAIRWNEEDQGVTFEYEDIPADLQDLAEEWHNNLIESAAEASEDLMDKYLGGEELSEAEIKSALRKRVLDNEIILVTCGSAFKNKGVQAMLDAVIEYLPAPTDVPAIKGILPDGKDTPAERHSSDEEPFSALAFKIATDPFVGNLTFFRVYSGVVNSGDTVLNPVKDKKERFGRIVQMHANKREEIKEVRAGDIAAAIGLKDVTTGDTLCAIDAPIILERMEFPEPVISVAIEPKTKADQEKMGIALNRLAQEDPSFRVSSDEESGQTIIAGMGELHLDVLVDRMRREFKVEANVGKPQVAYRETIREEITDVEGKHAKQSGGRGQYGHVVIDLSPLPSGGEENYVFVNDIVGGVIPKEFIPAVDKGIQEQLKSGPLAGYPVVDIKARLHFGSYHDVDSSEIAFKIAASMAFKEGFMKAKPILLEPIMKVEIETPEDYMGDVIGDLNRRRGMVEGMDDLPTGKIIRAQVPLAEMFGYATDLRSQTQGRASYSMEFLKYNEAPSNVAQAIIEARKAK MAREFSLEKTRNIGIMAHIDAGKTTTTERILYYTGRIHKIGETHEGASQMDWMEQEQDRGITITSAATTAAWEGHRVNIIDTPGHVDFTVEVERSLRVLDGAVTVLDAQSGVEPQTETVWRQATTYGVPRIVFVNKMDKLGANFEYSVSTLHDRLQANAAPIQLPIGAEDEFEAIIDLVEMKCFKYTNDLGTEIEEIEIPEDHLDRAEEARASLIEAVAETSDELMEKYLGDEEISVSELKEAIRQATTNVEFYPVLCGTAFKNKGVQLMLDAVIDYLPSPLDVKPIIGHRASNPEEEVIAKADDSAEFAALAFKVMTDPYVGKLTFFRVYSGTMTSGSYVKNSTKGKRERVGRLLQMHANSRQEIDTVYSGDIAAAVGLKDTGTGDTLCGEKNDIILESMEFPEPVIHLSVEPKSKADQDKMTQALVKLQEEDPTFHAHTDEETGQVIIGGMGELHLDILVDRMKKEFNVECNVGAPMVSYRETFKSSAQVQGKFSRQSGGRGQYGDVHIEFTPNETGAGFEFENAIVGGVVPREYIPSVEAGLKDAMENGVLAGYPLIDVKAKLYDGSYHDVDSSEMAFKIAASLALKEAAKKCDPVILEPMMKVTIEMPEEYMGDIMGDVTSRRGRVDGMEPRGNAQVVNAYVPLSEMFGYATSLRSNTQGRGTYTMYFDHYAEVPKSIAEDIIKKNKGE 101.59 gnl|BL_ORD_ID|4704|hsp_num:0 2254 Z1_01339 Elongation factor Tu 1 Strict 700 753.4 Escherichia coli EF-Tu mutants conferring resistance to Pulvomycin 94.67 3003369 protein variant model R234F elfamycin antibiotic antibiotic target alteration elfamycin resistant EF-Tu MSKEKFERSKPHVNVGTIGHVDHGKTTLTAAITTVLAKTYGGAARAFDQIDNAPEEKARGITISTSHVEYDTPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFLNKCDMVDDEELLELVEMEVRELLSQYDFPGDDTPVIRGSALKALEGEAEWEAKIVELAEALDSYIPEPERAIDKPFLLPIEDVFSISGRGTVVTGRVERGIIKVGDEVEIVGIKETAKTTCTGVEMFRKLLDEGRAGENVGVLLRGTKREEIERGQVLAKPGSINPHNKFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNVNMIVELIHPIAMDEGLRFAIREGGRTVGAGVVAKVLG MLSPEGESTIVRNIAVSKEKFERTKPHVNVGTIGHVDHGKTTLTAAITTVLAKTYGGAARAFDQIDNAPEEKARGITINTSHVEYDTPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFLNKCDMVDDEELLELVEMEVRELLSQYDFPGDDTPIVRGSALKALEGDAEWEAKILELAGFLDSYIPEPERAIDKPFLLPIEDVFSISGRGTVVTGRVERGIIKVGEEVEIVGIKETQKSTCTGVEMFRKLLDEGRAGENVGVLLRGIKREEIERGQVLAKPGTIKPHTKFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNIKMVVTLIHPIAMDDGLRFAIREGGRTVGAGVVAKVLG 96.33 gnl|BL_ORD_ID|1973|hsp_num:0 2158 Z1_01346 DNA-directed RNA polymerase subunit beta Loose 2300 689.5 Mycobacterium tuberculosis rpoB mutants conferring resistance to rifampicin 57.88 3003283 protein variant model S531G, H526S, D516N, L511R rifamycin antibiotic antibiotic target alteration; antibiotic target replacement rifamycin-resistant beta-subunit of RNA polymerase (rpoB) MVYSYTEKKRIRKDFGKRPQVLDVPYLLSIQLDSFQKFIEQDPDGQNGLEAAFRSVFPIQSYSGNAELQYVSYRLGEPVFDVKECQIRGVTYSAPLRVKLRLVIYEREAPEGTVKDIKEQEVYMGEIPLMTDNGTFVINGTERVIVSQLHRSPGVFFDSDKGKTHSSGKVLYNARIIPYRGSWLDFEFDPKDNLFVRIDRRRKLPATIILRAMNYSTEDILNLFFEKTTFEISNNKLMMTLVPERLRGETASFDIEANGKVYVEKGRRITARHIRQLEKEQIERIEVPVEYIAGKVVARDYIDEATGELICAANMEISLDVLARLSQAGHKTIETLFTNDLDHGAYISETIRVDPTNDRLSALVEIYRMMRPGEPPTREAAENLFENLFFSEDRYDLSAVGRMKFNRSLGREEVEGSGILSQEDIIEVMKKLIDIRNGKGEVDDIDHLGNRRIRSVGEMAENQFRVGLVRVERAVKERLSLGDLDALMPQDMINAKPISAAVKEFFGSSQLSQFMDQNNPLSEITHKRRISALGPGGLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSLSVYAQTNEYGFLETPYRVVENNAVTDEIHYLSAIEEGNFIIAQANSVLDDDGHFVEELVTCRHKGESSLFSRDQVQYMDVSTQQVVSVGASLIPFLEHDDANRALMGANMQRQAVPTLRGDKPLVGTGMERAVAVDSGVTAVAKRGGTVQYVDASRIVIKVNEDETYAGEAGIDIYSLTKYTRSNQNTCINQTPCVSLGEPVERGDVLADGPSTDLGELALGQNMRVAFMPWNGYNYEDSILVSERVVQEDRFTTIHIQELACVSRDTKLGPEEITADIPNVGEAALSKLDESGIVYIGAEVKGGDILVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDSSLRVPNGVSGTVIDVQVFTRDGVEKDKRALEIEESQLREVKKDLTEELRIFEAGLFARIRGVLIAGGIEADKLDKLPRERWLELGLADEEKQNQLEQLAEQYDELKAEFAKKLEAKRRKITQGDDLAPGVLKIVKVYLAVKRQIQPGDKMAGRHGNKGVISKINPIEDMPYDENGNPVDLVLNPLGVPSRMNIGQILETHLGMAAKGIGDKINAMLKQQQEVAKLREFIQKAYDLGMAPRQKVDLDTFSDEEVLRLAENLKKGMPTATPVFDGAEEMEIKEMLKLADLPTSGQITLFDGRTGEQFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVNGRTKMYKNIVDGNHQMEPGMPESFNVLLKEIRSLGINIELEDE MADSRQSKTAASPSPSRPQSSSNNSVPGAPNRVSFAKLREPLEVPGLLDVQTDSFEWLIGSPRWRESAAERGDVNPVGGLEEVLYELSPIEDFSGSMSLSFSDPRFDDVKAPVDECKDKDMTYAAPLFVTAEFINNNTGEIKSQTVFMGDFPMMTEKGTFIINGTERVVVSQLVRSPGVYFDETIDKSTDKTLHSVKVIPSRGAWLEFDVDKRDTVGVRIDRKRRQPVTVLLKALGWTSEQIVERFGFSEIMRSTLEKDNTVGTDEALLDIYRKLRPGEPPTKESAQTLLENLFFKEKRYDLARVGRYKVNKKLGLHVGEPITSSTLTEEDVVATIEYLVRLHEGQTTMTVPGGVEVPVETDDIDHFGNRRLRTVGELIQNQIRVGMSRMERVVRERMTTQDVEAITPQTLINIRPVVAAIKEFFGTSQLSQFMDQNNPLSGLTHKRRLSALGPGGLSRERAGLEVRDVHPSHYGRMCPIETPEGPNIGLIGSLSVYARVNPFGFIETPYRKVVDGVVSDEIVYLTADEEDRHVVAQANSPIDADGRFVEPRVLVRRKAGEVEYVPSSEVDYMDVSPRQMVSVATAMIPFLEHDDANRALMGANMQRQAVPLVRSEAPLVGTGMELRAAIDAGDVVVAEESGVIEEVSADYITVMHDNGTRRTYRMRKFARSNHGTCANQCPIVDAGDRVEAGQVIADGPCTDDGEMALGKNLLVAIMPWEGHNYEDAIILSNRLVEEDVLTSIHIEEHEIDARDTKLGAEEITRDIPNISDEVLADLDERGIVRIGAEVRDGDILVGKVTPKGETELTPEERLLRAIFGEKAREVRDTSLKVPHGESGKVIGIRVFSREDEDELPAGVNELVRVYVAQKRKISDGDKLAGRHGNKGVIGKILPVEDMPFLADGTPVDIILNTHGVPRRMNIGQILETHLGWCAHSGWKVDAAKGVPDWAARLPDELLEAQPNAIVSTPVFDGAQEAELQGLLSCTLPNRDGDVLVDADGKAMLFDGRSGEPFPYPVTVGYMYIMKLHHLVDDKIHARSTGPYSMITQQPLGGKAQFGGQRFGEMECWAMQAYGAAYTLQELLTIKSDDTVGRVKVYEAIVKGENIPEPGIPESFKVLLKELQSLCLNVEVLSSDGAAIELREGEDEDLERAAANLGINLSRNESASVEDLA 114.51 gnl|BL_ORD_ID|1960|hsp_num:0 1237 Z1_01390 UvrABC system protein A Loose 900 41.6 msrH 30.77 3005088 protein homolog model n/a n/a macrolide antibiotic; streptogramin antibiotic antibiotic target protection msr-type ABC-F protein MDKIEVRGARTHNLKNINLVIPRDKLIVITGLSGSGKSSLAFDTLYAEGQRRYVESLSAYARQFLSLMEKPDVDHIEGLSPAISIEQKSTSHNPRSTVGTITEIHDYLRLLFARVGEPRCPDHDIPLAAQTVSQMVDNVLAQPEGKRLMLLAPIVKERKGEHVKLLNNLAAQGYIRARIDGEVCDLSDPPTLELQKKHTIEVVIDRFKVRDDLAQRLAESFETALELSGGTAVISDMDDSSTEDIVFSANFACPICGYSMSELEPRLFSFNNPAGACPTCDGLGVQQFFDPDLVIQNREISLAGGAIKGWDRRNFYYFQMLRSLGEHYHFDVEAPFDSLPDKIQKVILSGSGKENIEFKYTNDRGDVVVRHHPFEGVLNNMERRYRETESSAVREELAKYISNRPCASCGGTRLRREARHVYVENTTLPEIADYSIGHAMSFFQNLKLSGQRAKIAEKVLKEIGDRLKFLVNVGLNYLTLSRSAETLSGGEAQRIRLASQIGAGLVGVMYVLDEPSIGLHQRDNDRLLETLIHLRDLGNTVIVVEHDEDAIRAADHIIDIGPGAGVHGGEIVAQGTLEDIVNNPNSLTGKFLSGERRIAIPEKRVPVDREKMLTILGAKGNNLKNVNLKIPVGLFTCITGVSGSGKSTLINDTLFPIAQRQLNGATNSVPAPYLDVEGLEHFDKVIDINQSPIGRTPRSNPATYTGVFTPIRELFAGVPESRTRGYTPGRFSFNVKGGRCEACQGDGVLKVEMHFLPDVYVPCDQCKGQRYNRETLEIKYKGKNIHEALDMTIEEAREFFDAVPALARKLQTLIDVGLSYIRLGQSATTLSGGEAQRVKLAKELSKRGTGQTLYILDEPTTGLHFADIELLLDVLHQLRDQGNTIVVIEHNLDVIKTADWIVDLGPEGGSGGGQILISGTPEQVADFEGSHTARFLKPILERGY MEQICFELENIELSYLDKKVLDIDRLAIHQFDRIGIVGRNGAGKSTLLKIIGGIINPSRGKVNQYVEYGYFEQLEGPIAKATNPRLLGKLQVKENASNLSGGEQTRLKLAQLFTHFYDALLIDEPTTHLDQDGISFLIEELKNYYGALILISHDRAFLDELVTTIWEIDEGTVKIYSGNYSDYMRQKQIERTQQVYNHEQFLKEKNRLEKASLEKMKKAEKIAKSTSMSKKESKAKPNRMFESKSKGTSQKSLQRAAKAIEQRINQLQVVEAPNDDYVIHFHSTNNISKLHNKFPIMGDCITLEIDDKVLLKETSFQFPLGKTIAITGKNGSGKTTLIRHIIENGEGITISPKAEIGIYEQMGYQFDEDKTVLSYIKDRSDYDESKIRSVLNAMSFTGNDLKKKVQNLSGGESIRLVLCQLFLGRYNILVLDEPTNFLDIFCIEALESILKEYKGTVIIISHDKKFVEHVSDIVYRIENQKLKLVN 194.24 gnl|BL_ORD_ID|2814|hsp_num:0 3822 Z1_01394 Alanine racemase, biosynthetic Loose 200 154.5 vanT gene in vanE cluster 33.79 3002971 protein homolog model n/a n/a glycopeptide antibiotic antibiotic target alteration glycopeptide resistance gene cluster; vanT MKAATAVIDRRALRHNFQHVRDYAPHSHLIAVVKANAYGHGLLETAYTLMDDADCFGVARIGEALTLRSGGIVKPILLLEGFFDAVDLPILVVNHIETVVHSEEQLEALENADLEEPVKVWMKLDTGMHRLGVRPEEAEAFYQRLCACKNVQQPVNLVSHFSRADEPDIPEVTQNQIQLFQAFIQDKAGDKSIAASAGILFWPQVHYQWVRPGIITYGISPTGDNRTGKDFGLTPAMTLKTSLIAVRKHKAGEPVGYGGTWVSEKDTYLGVIAIGYGDGYPRSAPSGTPVWINGRKVPIVGRVSMDMISVDLGSELIDRVGDEAILWGDVLPVEEIAKYSGISAYELITKLTSRVIMEYLDEQ MKHRANGIDLFRIFAATMVVAIHTFPFQSIAPFLDEVITLTVFRVAVPFFFMITGYFLLGRLSLNFSYNNNQRVKKYLYKIGMIYLYSILLYFPLSLLNGTISLKMNILLLLKVFIFDGTFYHLWYFPASIIGTILVTLLLRSIGFKLTVAFSTCLYLVGLGGDSWYGITNQVPLLNKLYTFIFSWSDYTRSGVFFTPVFLCLGIFAYRVSKKLTASKILNLLFYVFIIGMTFESIFLHRFTNVKHDSMYLLLPSCALILFLMLLNWQPKLKVKESADLTLLVYILHPLVIVIVHSISKYIPILKNSLLNFLLVVVCSFILAQLLLNLKRKLRVSKQKIPFERASKEISASAIHHNINEIRKIIPKNTNIMGVVKANAYGCGMVEVAYELEKIGISFFCVATIEEAIALRKSGNQGDILILGYTHPNRINDIKKYNLIQSIVSEEHGKVLNLKKIPIRCHLQVDTGMHRLGVTPNVTIIQQMYLFSNLKIEGIYSHLGSSDSLEQESIARTNTQIFLFNNILSDLEQMGISYGYTHIQSSYGILNYPELSFDFVRIGILCYGFLSDYNSPTKIPIDLQPIVKVKASLITERIVEAGEYVGYGLGAKVEKRTRIGVVSIGYADGIPRALSNAKLTLEFKGQSIKQIGNICMDMMLVDLSEVEDISLNDELIVLPNISKIADEEQTITNELLSRLGSRLGTELN 51.71 gnl|BL_ORD_ID|4689|hsp_num:0 1308 Z1_01399 Spermidine/putrescine import ATP-binding protein PotA Loose 500 133.3 RanA 31.4 3005091 protein homolog model n/a n/a aminoglycoside antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MTEKTSLTPLVELKSLSKGFDGKQIISRLDLTINHGEFLTILGPSGCGKTTVLRLIAGLEDADDGQIILDGQDITHIPAEQRFVNTVFQSYALFPHMTVFENVAFGLRMQKTPAAEINNRVMEALRMVQLEDFAQRRPAHLSGGQQQRVAIARAVVNKPKVLLLDESLSALDYKLRKQMQNELKALQRKLGITFIFVTHDQEEALTMSDRIVVMKEGRIEQDGTPREIYEEPTNLFVAQFIGEINIFDARVLHRIDETRIRADVEGHECDIYTQLPVTQNQQLKVLLRPEDLRVEEIHDLENLPGLIGYVRERNYKGMTLDSVVEMENGKMVMVSEFFNEDDPDVDHSLDQKIAVTWVESWEVVLADEENT MIEVKDLRKSFNDVEVLKGITTTFETGKINLVIGQSGSGKTVFLKCLLNVFDPSSGDILFDGRNLSIMGRTEKQEIRSEIGTVFQGSALFDSMTVEENISFPLDMFTNLTYTEKRKRVKEVIGRVHLENANTKFPSEISGGMQKRVAIARAIVNNPKYLFCDEPNSGLDPNTAIVIDELIKEITEEYNTTTIINTHDMNSVLTIGEKIVYLRKGVKEWEGNKDLIIKAENEHLIDFVYSSALFKQVRETMLRNNQTNL 143.80 gnl|BL_ORD_ID|2817|hsp_num:0 3825 Z1_01411 HTH-type transcriptional regulator BetI Loose 375 42.0 Escherichia coli AcrAB-TolC with AcrR mutation conferring resistance to ciprofloxacin, tetracycline, and ceftazidime 23.64 3003807 protein overexpression model n/a n/a fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic target alteration; antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MNTTAHHRKKDPIRVQEQLLEAASIIVANEGIASLSLNAVAKEAGVSKGGLLHHFPGKIELIQAVFKRLLGIMDKRIALIMANDPIEAGRFSRAYLTYISDLKQSDESRQLAILSLAMPNEPIMRQCWRDWMLGHLAKGDKLDNSYLGTLIRYAADGLWLSELTEGPTISQQERSALVERLLKMTFEYMADTANQSC MARKTKQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSESNIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVGEMAVVQQAQRNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYISGLMENWLFAPQSFDLKKEARDYVAILLEMYLLCPTLRNPATNE 91.63 gnl|BL_ORD_ID|2095|hsp_num:0 2306 Z1_01425 Spermidine export protein MdtJ Loose 190 90.1 qacE 41.67 3005009 protein homolog model n/a n/a disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MSPKAKSWLWMLAVIISETSATSTLKMFDNSEGITKTLLLGLIIVLYIVCYYSLSRAVKNIPVGLAYATWSGTGILVVSTLGMAFYGQHPDTAAIIGMAVIASGIVIMNLFSKMGSEEESEETTELSNIKQTVSSVNK MKGWLFLVIAIVGEVIATSALKSSEGFTKLAPSAVVIIGYGIAFYFLSLVMKSIPVGVAYALWSGLGVVIITAIAWLLHGQKLDAWGFVGMGLIVSGVVVLNLLSKASAH 125.45 gnl|BL_ORD_ID|2752|hsp_num:0 3754 Z1_01426 Multidrug transporter EmrE Strict 75 85.5 qacJ 37.86 3007014 protein homolog model n/a n/a disinfecting agents and antiseptics antibiotic efflux small multidrug resistance (SMR) antibiotic efflux pump MFTGFLWLALSIGSEITGTSMIKKTNGFSKLAPSVLVIAAYCICYFALTRAMGYIPVGVAYSLWCGFGIVGVTLVAMILYKQKPDLPAIFSMALIISGGIIMNTFSTM MPYLYLVIAIITEIIGTSFLKTAEGFTKLWPTLGTLISFGICFYFLSVTMKYLPLNVSYATWAGLGLVLTTIVSVVIFKESVNLISIFSIILIIIGVVLLNVFGSSH 100.93 gnl|BL_ORD_ID|4668|hsp_num:0 5730 Z1_01428 Efflux pump membrane transporter BepE Loose 1900 1504.2 MexI 77.28 3000808 protein homolog model n/a n/a fluoroquinolone antibiotic; tetracycline antibiotic; disinfecting agents and antiseptics antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MKFTDIFVRRPVLALVVSTLIFLLGAFAFSKLPIRQYPMLQNSTITIATDYPGASSELMQGFVTQPITQAVSSVEGVDYISSSSVQGKSFVTVRMELNRDPTQALTQVMAKVNQVRYKLPEQAYDPVIELSSGESTAVAYVGFSSEQISIPELTDYLSRVVEPMFSSINGVAKVQVFGGQQLAMRVWLDTDKLAGRNLTASDVADAIRRNNYQAAPGKVEGEFVIANVYVNTDLTNVEEFKDMVIHNDGHNLIRLRDIGTVELGAAATETSGIMNGKKAVFLGLFPTPTGNPLIIVDGIRENLTDIEKTLPPGVNVELAFETSRFIKASIDQVVQTLIEAILIVIAVIYLCLGSLRSVIIPVLAIPLSMLGAAGLMLAFGFSINLLTLLAMVLAIGLVVDDAIVVVENVHRHIEEGLSPVQAALVGAREVAGPVIAMTITLAAVYAPIGLMSGLTGALFKEFAITLAGSVIVSGIVALTLSPVMSSLMLKPKENEGRMAKIAEYTFDKLTYYYSYLLNFSLTHRWLTVVFALAVFVSLPFLYSQTKQELAPLEDQASVLTAVKAPQHANLAYAEHFNQKLDDIYMSLPETDSTWIINGTDGPSASFGGINFDGWKGRDRNANQIQADLQNRVADVEGSSIFAFQLASLPGSVGGLPVQMVLRSPLGYPVLFDTMEEIKQQARESGLFVVVDSDLDYNNPVVQITIDRAKANTLGIRMQDIGESLSLLVGEHYINRFGMDGRSYDVIPQSIRQQRLTPAALAGHYIRTQDNLLIPLSTVVNITTQVEPNKLTQFNQQNAAIFQAIPAPGVTMGQAVAFLEHVANSLPAGFSHDWQSDARQFTQEGNTLVFAFIAALIVIYLVLAAQYESLVDPLIILITVPLSICGALVPLALGMVTLNIYTQIGLVTLIGLISKHGILMVEFANELQVHKNLNRREAIVEAAKIRLRPVLMTTAAMVIGLIPLLFASGAGANSRYGLGLIIVSGMLVGTLFTLFVLPTMYSFLARNHQVSAQTERQKQLQQISEQ MTFTDLFVRRPVLALVVSTLILLLGLFSLGKLPIRQYPLLESSTITVTTEYPGASADLMQGFVTQPIAQAVSSVEGIDYLSSTSVQGRSVVTIRMLLNRDSTQAMTETMAKVNSVRYKLPERAYDSVIERSSGETTAVAYVGFSSKTLPIPALTDYLSRVVEPMFSSIDGVAKVQTFGGQRLAMRLWLDADRLAGRGLTASDVAEAIRRNNYQAAPGMVKGQYVLSNVRVNTDLTNVDDFREMVIRNDGNGLVRLRDVGTVELGAAATETSALMDGDPAVHLGLFPTPTGNPLVIVDGIRKLLPEIQKTLPPDVRVDLAYETSRFIQASIDEVVRTLVEALLIVVLVIYLCLGSLRSVLIPVATIPLSMLGAAALMLAFGFSVNLLTLLAMVLAIGLVVDDAIVVVENVHRHIEEGKSPVAAALIGAREVAGPVIAMTITLAAVYTPIGLMGGLTGALFREFALTLAGAVIVSGVVALTLSPVMSSLLLQAHQNEGRMGRAAEWFFGGLTRRYGQVLEFSLGHRWLTGGLALLVCISLPLLYSMPKRELAPTEDQAAVLTAIKAPQHANLDYVELFARKLDQVYTSIPETVSTWIINGTDGPAASFGGINLAAWEKRERDASAIQSELQGKVGDVEGSSIFAFQLAALPGSTGGLPVQMVLRSPQDYPVLYRTMEEIKQKARQSGLFVVVDSDLDYNNPVVQVRIDRAKANSLGIRMQDIGESLAVLVGENYVNRFGMEGRSYDVIPQSLRDQRFTPQALARQFVRTQDGNLVPLSTVVRVALQVEPNKLIQFDQQNAATLQAIPAPGVSMGQAVAFLDDVARGLPAGFSHDWQSDSRQYTQEGNTLVFAFLAALVVIYLVLAAQYESLADPLIILITVPLSICGALLPLALGYATMNIYTQIGLVTLIGLISKHGILMVEFANELQLHERLDRRAAILRAAQIRLRPVLMTTAAMVFGLVPLLFASGAGAASRFGLGVVIVSGMLVGTLFTLFVLPTVYTLLARNHAEVDKSPRSRQLAEADLLVNKA 99.61 gnl|BL_ORD_ID|4692|hsp_num:0 1647 Z1_01429 Multidrug resistance protein MdtA Loose 650 355.9 MexH 53.46 3000807 protein homolog model n/a n/a fluoroquinolone antibiotic; tetracycline antibiotic; disinfecting agents and antiseptics antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MNKKLTLTLCASLFLLSAGAMVYATMGSDEDETQPFAYPPTKVALATAQSAELPNTMHGVGELEAARQVYLAAETNGRIATIHFASGQTVTAGQILVKLNDEPEQAELLRLQAQLTNAEKLYSRTRQLYSKNVAAAAQLDSTLSERDMIVASIREVKARIAQKTIKAPFDGIVGIKLVHEGQYLNAGERVASLVDASHLKLNFSLDEQVAPQLSTHQPINIAVDAYPNQTFTGSLNAIDPLIGPSRTVQVQAILPNTDNKLKAGMFARVQVTSPTRHQALTVPETAVTYTAYGDTVFVAQSDNQKNLIAKRVSVKVGLRYNGLIEIKEGLNQGDQVVTSGQIKLSDGTSIAPIEQDTLTLAQSTTRQP MQKPVLIASAALICAAVIGIAVYATGSAKKDAGGFAGYPPVKVALASVERRVVPRVFDGVGELEAGRQVQVAAEAAGRITRIAFESGQQVQQGQLLVQLNDAVEQAELIRLKAQLRNAEILHARARKLVERNVASQEQLDNAVAARDMALGAVRQTQALIDQKAIRAPFSGQLGIRRVHLGQYLGVAEPVASLVDARTLKSNFSLDESTSPELKLGQPLEVLVDAYPGRSFPARISAIDPLIGKSRTVQVQALLDNPEGLLAAGMFASIRVSRKADAPSLSVPETAVTYTAYGDTVFVAHQDGDRPLSAKRVSVRIGERWDGRVEILQGLAEGDRVVTSGQINLSDGMAVEPVKEDTLSSAAPPVPVAGR 99.46 gnl|BL_ORD_ID|1353|hsp_num:0 1344 Z1_01430 hypothetical protein Loose 260 160.2 MexG 62.79 3000806 protein homolog model n/a n/a fluoroquinolone antibiotic; tetracycline antibiotic; disinfecting agents and antiseptics antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MPNSIARILESQTLWIVARVLILLLFLSSGFAKVFDYENSLAEMRAAGLNPDWFFNLASAIVLFAGSILVLFDRYLWLGAGALATFLFLTIVIVHTFWNMTGDKAMLSMYFAIEHTSVIGGLMATAMASHFRALWKKFNS MQRFIDNSLESNWLWLTARICLALMFVASGLAKLFDYQASLEEMRAAGLEPAWLFNIATAVTLLAGSALVLLDRKLWLGAGALAVFLLLTILIVHTFWSKTGVEAKLAMFFALEHIAVIGGLIATAIASAQRQRLRQDVSVAATYQKA 94.59 gnl|BL_ORD_ID|4686|hsp_num:0 995 Z1_01431 Redox-sensitive transcriptional activator SoxR Loose 300 171.8 Escherichia coli soxR with mutation conferring antibiotic resistance 57.72 3003381 protein overexpression model n/a n/a fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic target alteration; antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump MSKEKIDFNRALTVGEVAKRSGVPISTLHFYEEKGLIKSSRSPGNQRRYPSVVLRYVAIIKAAQSTGIPLKEIQEILGKYPPNSKLTAEQWHEISTDWKIRLDERIRRLKRLRNGLDHCIGCGCLSLNDCPLRNPDDILGEKGPSAQML MEKKLPRIKALLTPGEVAKRSGVAVSALHFYESKGLITSIRNSGNQRRYKRDVLRYVAIIKIAQRIGIPLATIGEAFGVLPEGHTLSAKEWKQLSSQWREELDRRIHTLVALRDELDGCIGCGCLSRSDCPLRNPGDRLGEEGTGARLLEDEQN 96.75 gnl|BL_ORD_ID|1976|hsp_num:0 1005 Z1_01458 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial Loose 400 38.9 Erm(K) 23.61 3004643 protein homolog model n/a n/a macrolide antibiotic; lincosamide antibiotic; streptogramin antibiotic antibiotic target alteration Erm 23S ribosomal RNA methyltransferase MNTIETTDFAELYKNHMQQAQRTKKEPEHWDKRAEKMAENCANPNDPYLIKFREMMDFSDAETLLDVGCGPGSISIHVADKFKKIIGIDYSTGMLTVAKRRAAQAGIHHADFLHYSWEDNWDALPPCDIAVASRSTLVMDLKTALLKLNRQAKLRVYTTHTVSPTFVDQRILRLLGRNVPTLPTYIYAVNILNQMGIHPKVDYIRSRNCQNNFNSLEQFIDSINFSVGPLNENEIAHLTTYYHESMKNDVALISPTRDWAMVSWDVVPESELTL MTKKKHKYSNKKLSRGEPPNFSGQHLMHNKKLLQEIVDQAKVSKKDTVLELGAGKGALTTFLSERAKRVLAVEYDQTFIQVLNRKMAHAANTTIIHEDIMRIHLPKGEFVVVSNIPYSITTPIMKKLLSNPVSGFQRGVIVMEKGAAKRFTSPFIKNAYVLAWRMWFDLEYVKGISRECFSPPPKVDSAMVFISRKPDPIVPYKDRSAFFGLAEYALREPKAPADSLLRGIFTATQLKHVKRNAGIKHDVSIGALSERQWGVIFETMTQYVRRPLWPRPRKTTL 96.48 gnl|BL_ORD_ID|2128|hsp_num:0 3341 Z1_01459 putative ABC transporter ATP-binding protein Loose 600 85.9 oleC 26.37 3003748 protein homolog model n/a n/a macrolide antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MIITAAKQLTIGYKTTPLIQNLSFNIKQGQIVCLLGANGCGKTTLMRTLLGLLPSLAGHIIIEGKEISKWSPTDLAKVIAYVPQATHLPFSFKVIDMVIMGRGAHISFFSMPSSQDKAMAMETLEMLSLSHLAHRTFDTLSGGEKQLVLIARALVQQPKLLIMDEPAASLDFGNQIKLINQIKTLKALGISVFMSTHHPQHAALLADEVILLTPHRHVLQDKPELLLTPEHLAQLYNVKPTDIQAHFYAYPDNNNPYRQEYEHH MTVRGLVKHYGETKALDGVDLDVREGTVMGVLGPNGAGKTTLVRILSTLITPDSGQATVAGYDVVRQPRQLRRVIGLTGQYASVDEKLPGWENLYLIGRLLDLSRKEARARADELLERFSLTEAARRPAGTYSGGMRRRLDLAASMIGRPAVLYLDEPTTGLDPRTRNEVWDEVKAMVGDGVTVLLTTQYMEEAEQLASELTVVDRGRVIAKGGIEELKARVGGRTLRVRPVDPLQLRPLAGMLDELGITGLASTTVDTETGALLVPILSDEQLTAVVGAVTARGITLSSITTELPSLDEVFLSLTGHRASAPQDAEPARQEVAV 81.23 gnl|BL_ORD_ID|2055|hsp_num:0 2264 Z1_01488 Inner membrane metabolite transport protein YgcS Loose 990 57.4 qacB 32.76 3003047 protein homolog model n/a n/a fluoroquinolone antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MQPRNFDDIRFTSVHRRVMLWGSGGPFLDGYVLVIIGVALEQLTPILQLDTRWIGLLGAATLAGLFIGTSLFGYICDKVGRRKMFLVDIVAIAVISIATMFVSTPIGLLVMRFLIGIVIGADYPIATSMITEFSNKKQRAFAVGFIAAMWYIGATCANLVGYLLYDVQDGWRWMLGSAFIPCVIILIGRFDLPESPLWLIRQGRIKECNKMMIKLFGEPVVFEAEDAKTTRFIELFNKRHFSFVLFVAVIWTCQVIPMFAIYTFGPQIVSLLGWDTGRSAALGNVVISLFFMLGCIPAMFWLNQTGRRPLLIGSFAMMTLALFTLGIFPNLPILFVILAFATYAFFSGGPGILQWLYPNELFPTDIRASAVGVIMSISRIGTVISTCALPAFIATYGINTTMLVGAAISLFGMMVSVLFAPETKGLTLKQTSTMPMRRGK MISFFTKTTDMMTSKKRWAALVVLAVSLFVVTMDMTILIMALPELVRELEPSGTQQLWIVDIYSLVLAGFIIPLSAFADKWGRKKALLTGFALFGLVSLAIFFAESAEFVIAIRFLLGIAGALIMPTTLSMIRVIFENPKERATALAVWSIVSSIGAVFGPIIGGALLEQFSWHSAFLINVPFAIIAVVAGLFLLPESKLSKEKSHSWDIPSTILSIAGMIGLVWSIKEFSKEGLADIIPWVVIVLAITMIVIFVKRNLSSSDPMLDVRLFKKRSFSAGTIAAFMTMFAMTSVLLLASQWLQVVEELSPFKAGLYLLPMAIGAMVFAPIAPGLAARFGPKIVLPSGIGIAAIGMFIMYFFGHPLSYSTMALALILVEAGTASLAVASALIMLETPTSKAGNAAAVEESMYDLGNVFGVAVLGSLSSMLYRVFLDISSFSSKGIVGDLAHVAEESVVGAVEVAKATGIKQLANEAVTSFNDAFVATALVGGIIMIIISIVVYLLIPKSLDITKQK 85.60 gnl|BL_ORD_ID|509|hsp_num:0 558 Z1_01527 Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase Loose 550 48.9 PmrF 31.25 3003578 protein homolog model n/a n/a peptide antibiotic antibiotic target alteration pmr phosphoethanolamine transferase MSSSFPQLSIVVAVFNGEKFLPQFFNCLHAQQLENWELILVDDGSTDNSRQILDKWEKHFPNVTILTQENQGVSVARNTGFAVAKGEYVAFPDIDDVIDKRMYPRLLEIAKADNLDVATCNGNYIYDDKNRPTRPIFPSTRLTTTEVLTGPQWLERALESKKFLHVTWLNIYRRQFLLEHGYYFEPGLHHQDIPWTTEVLLTAKRVKYIDERYYDYFIHSGSVSHTTPDDRIHVRTIYNYMKILEMLDAINQRHAEIAKTINACYWQIAKEGLGIIHSIDAISSPETKKQIVKVFFERGIWALIWKNAKDFRLKWRLGRRYFRLKKILAE MFEIHPVKKVSVVIPVYNEQESLPELIRRTTTACESLGKEYEILLIDDGSSDNSAHMLVEASQAENSHIVSILLNRNYGQHSAIMAGFSHVTGDLIITLDADLQNPPEEIPRLVAKADEGYDVVGTVRQNRQDSWFRKTASKMINRLIQRTTGKAMGDYGCMLRAYRRHIVDAMLHCHERSTFIPILANIFARRAIEIPVHHAEREFGESKYSFMRLINLMYDLVTCLTTTPLRMLSLLGSIIAIGGFSIAVLLVILRLTFGPQWAAEGVFMLFAVLFTFIGAQFIGMGLLGEYIGRIYTDVRARPRYFVQQVIRPSSKENE 102.48 gnl|BL_ORD_ID|1940|hsp_num:0 2014 Z1_01531 Metal-staphylopine import system ATP-binding protein CntD Loose 1280 76.6 macB 31.28 3000535 protein homolog model n/a n/a macrolide antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MLSFEQLSIDIAQFRWLGKRTWQPLLKSISLDIKPGKMLALVGGSGEGKSLLLQSALGLLPANMRTRGTIKLNGHPLTERELIAYRGNTFCYIPQGVTALNPLISIGEQLGRSARLSGADITYEDIKHQFGLYHLSSSLVKTYPAKLSGGMAKRVLACNATLSNAQYILADEITSWLDDEHACLLLEHLKELCHQGKSVLWVTHDLALAARYADTIAVLRQGELNEIVAAKALYHHGGSEWLKTLWNALPEQQFLDLQEGACNPYPY MSLIECKNINRYFGSGENRVHILKDISLSIEKGDFVAIIGQSGSGKSTLMNILGCLDTAGSGSYRIDGIETAKMQPDELAALRRERFGFIFQRYNLLSSLTARDNVALPAVYMGMGGKERSARADKLLQDLGLASKEGNKPGELSGGQQQRVSIARALMNGGEIIFADEPTGALDTASGKNVMEIIRRLHEAGHTVIMVTHDPGIAANANRVIEIRDGEIISDTSKNPEIPASNVGRIQEKASWSFYYDQFVEAFRMSVQAVLAHKMRSLLTMLGIIIGIASVVSVVALGNGSQKKILEDISSMGTNTISIFPGRGFGDRRSGKIKTLTIDDAKIIAKQSYVASATPMTSSGGTLTYRNTDLTASLYGVGEQYFDVRGLKLETGRLFDENDVKEDAQVVVIDQNVKDKLFADSDPLGKTILFRKRPLTVIGVMKKDENAFGNSDVLMLWSPYTTVMHQITGESHTNSITVKIKDNANTRVAEKGLAELLKARHGTEDFFMNNSDSIRQMVESTTGTMKLLISSIALISLVVGGIGVMNIMLVSVTERTKEIGIRMAIGARRGNILQQFLIEAVLICIIGGLVGVGLSAAVSLVFNHFVTDFPMDISAASVIGAVACSTGIGIAFGFMPANKAAKLNPIDALAQD 41.46 gnl|BL_ORD_ID|447|hsp_num:0 487 Z1_01532 Glutathione import ATP-binding protein GsiA Loose 1200 64.3 TaeA 28.0 3003986 protein homolog model n/a n/a pleuromutilin antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MPLLALQQLSVQQAGKMLWHDLSFSLEAGERLGISAPSGRGKTTLGRVLAQWQMPTSGQILFNQQPLPKKGYCPIQLVPQHPDKCFNPFRTTGESVRDAWVPDSLWLEKLMIEPEWLTRRPNELSGGELARIALLRALDPRTQLLIADEVTAQLDAQIQAKIWQVLIDESQKRPLSLIIFSHNKALLEKVSTRIWWVDKEKTC MNILTVEQVTKSYGDKILFQDASFGMEDQDKIGIIGVNGTGKSTFLRVIAGLEPPDSGKISMGNRIRVRYLAQNPEFDPDKTVLQQVFEGDLPEMKAVREYTETMELLELHPSHEELQQKLLKLNQTLETLQAWQLESDAKTILSKLGIRNYEAKMGTLSGGQRKRVALAAALIQPSDLLILDEPTNHIDNESVAWLEQYLQKRRGALLMITHDRYFLDRVANVMLELDHGRLFRYEANYSRFLELKAEREEREAASEQKRQNLLRSELAWIRRGAKARTTKQKARIERFEKLKDQEMVHSSGELDVSVASTRLGRKILEIEGLRMKIDDKTLIQDLSYIAVPEDRIGIVGPNGSGKSTLLNLIAGRIQPGGGEVVLGPTVKLGYFTQEHQEMDGSQRVIEYIKDEAEVVRTADGSAITAAQMLERFLFPPALQWTPIAKLSGGEKRRLYLLRVLMSAPNVLLLDEPTNDLDIQTLSVLEQYLDEFPGVCIVVSHDRFFLDRTVDKIMAFEGDGQIRVHVGSYSEYAEWMQRHGGEASGSKAEASIAKSASGSSDGTDSDSAKEAPRERLKFSYKEQREFDQIDGLIEDTESKLASIQSEMETAGSDAARLQELMKAQEETERELEHLMERWTYLNELAEKIEQSKKS 31.33 gnl|BL_ORD_ID|2238|hsp_num:0 2522 Z1_01550 [Ribosomal protein S18]-alanine N-acetyltransferase Loose 300 39.3 SAT-4 32.84 3002897 protein homolog model n/a n/a nucleoside antibiotic antibiotic inactivation streptothricin acetyltransferase (SAT) MKTISPLNPADLPLAWEIEKLSHSFPWSEETFYSNQGDHYFNLKICIDNIMVGFAITQLILDEATLFNIAIHPDYQGKGYGKALLLELIDNIERKDIATLWLEVRESNQKASNLYESIGFNSVSVRKNYYPTATGKEDAIIMAYPIKF MITEMKAEHLKDIDKPSEPFEVIGKIIPRYENENWTFTELLYEAPYLKSYQDEEDEEDEEADCLEYIDNTDKIIYLYYQDDKCVGKVKLRKNWNRYAYIEDIAVCKDFRGQGIGSALINISIEWAKHKNLHGLMLETQDNNLIACKFYHNCGFKIGSVDTMLYANFENNFEKAVFWYLRF 82.22 gnl|BL_ORD_ID|1486|hsp_num:0 1505 Z1_01563 Inner membrane transport protein YdhC Strict 750 750.0 floR 99.5 3002705 protein homolog model n/a n/a phenicol antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MTTTRPAWAYTLPAALLLMAPFDILASLAMDIYLPVVPAMPGILNTTPAMIQLTLSLYMVMLGVGQVIFGPLSDRIGRRPILLAGATAFVIASLGAAWSSTAPAFVAFRLLQAVGASAMLVATFATVRDVYANRPEGVVIYGLFTSILAFVPALGPIAGALIGEFLGWQAIFITLAILAMLALLNAGFRWHETRPLDQVKTRRSVLPIFASPAFWVYTVGFSAGMGTFFVFFSTAPRVLIGQAEYSEIGFSFAFATVALVMIVTTRFAKSFVARWGIAGCVARGMALLVCGAVLLGIGELYGSPSFLTFILPMWVVAVGIVFTVSVTANGALAEFDDIAGSAVAFYFCVQSLIVSIVGTLAVALLNGDTAWPVICYATAMAVLVSLGLVLLRLRGAATEKSPVV MTTTRPAWAYTLPAALLLMAPFDILASLAMDIYLPVVPAMPGILNTTPAMIQLTLSLYMVMLGVGQVIFGPLSDRIGRRPILLAGATAFVIASLGAAWSSTAPAFVAFRLLQAVGASAMLVATFATVRDVYANRPEGVVIYGLFSSVLAFVPALGPIAGALIGEFLGWQAIFITLAILAMLALLNAGFRWHETRPLDQVKTRRSVLPIFASPAFWVYTVGFSAGMGTFFVFFSTAPRVLIGQAEYSEIGFSFAFATVALVMIVTTRFAKSFVARWGIAGCVARGMALLVCGAVLLGIGELYGSPSFLTFILPMWVVAVGIVFTVSVTANGALAEFDDIAGSAVAFYFCVQSLIVSIVGTLAVALLNGDTAWPVICYATAMAVLVSLGLVLLRLRGAATEKSPVV 100.00 gnl|BL_ORD_ID|2319|hsp_num:0 522 Z1_01565 hypothetical protein Strict 500 562.8 APH(6)-Id 99.64 3002660 protein homolog model n/a n/a aminoglycoside antibiotic antibiotic inactivation APH(6) MFMPPVFPAHWHVSQPVLIADTFSSLVWKVSLPDGTPAIVKGLKPIEDIADELRGADYLVWRNGRGAVRLLGRENNLMLLEYAGERMLSHIVAEHGDYQATEIAAELMAKLYAASEEPLPSALLPIRDRFAALFQRARDDQNAGCQTDYVHAAIIADQMMSNASELRGLHGDLHHENIMFSSRGWLVIDPVGLVGEVGFGAANMFYDPADRDDLCLDPRRIAQMADAFSRALDVDPRRLLDQAYAYGCLSAAWNADGEEEQRDLAIAAAIKQVRQTSY MFMPPVFPAHWHVSQPVLIADTFSSLVWKVSLPDGTPAIVKGLKPIEDIADELRGADYLVWRNGRGAVRLLGRENNLMLLEYAGERMLSHIVAEHGDYQATEIAAELMAKLYAASEEPLPSALLPIRDRFAALFQRARDDQNAGCQTDYVHAAIIADQMMSNASELRGLHGDLHHENIMFSSRGWLVIDPVGLVGEVGFGAANMFYDPADRDDLCLDPRRIAQMADAFSRALDVDPRRLLDQAYAYGCLSAAWNADGEQEQRDLAIAAAIKQVRQTSY 100.00 gnl|BL_ORD_ID|953|hsp_num:0 1031 Z1_01566 Aminoglycoside 3'-phosphotransferase Strict 500 553.1 APH(3'')-Ib 99.63 3002639 protein homolog model n/a n/a aminoglycoside antibiotic antibiotic inactivation APH(3'') MNRTNIFFGESHSDWLPVRGGESGDFVFRRGDGHAFAKIAPASRRGELAGERDRLIWLKGRGVACPEVINWQEEQEGACLVITAIPGVPAADLSGADLLKAWPSMGQQLGAVHSLSVDQCPFERRLSRMFGRAVDVVSRNAVNPDFLPDEDKSTPQLDLLARVERELPVRLDQERTDMVVCHGDPCMPNFMVDPKTLQCTGLIDLGRLGTADRYADLALMIANAEENWAAPDEAERAFAVLFNVLGIEAPDRERLAFYLRLDPLTWG MNRTNIFFGESHSDWLPVRGGESGDFVFRRGDGHAFAKIAPASRRGELAGERDRLIWLKGRGVACPEVINWQEEQEGACLVITAIPGVPAADLSGADLLKAWPSMGQQLGAVHSLLVDQCPFERRLSRMFGRAVDVVSRNAVNPDFLPDEDKSTPQLDLLARVERELPVRLDQERTDMVVCHGDPCMPNFMVDPKTLQCTGLIDLGRLGTADRYADLALMIANAEENWAAPDEAERAFAVLFNVLGIEAPDRERLAFYLRLDPLTWG 100.00 gnl|BL_ORD_ID|1693|hsp_num:0 1830 Z1_01567 Dihydropteroate synthase Strict 500 515.0 sul2 99.63 3000412 protein homolog model n/a n/a sulfonamide antibiotic antibiotic target replacement sulfonamide resistant sul MNKSLIIFGIVNITSDSFSDGGRYLAPDAAIAQARKLMAEGADVIDLGPASSNPDAAPVSSDTEIERIAPVLDALKADGIPVSLDSYQPATQAYALSRGVAYLNDIRGFPDAAFYPQLAKSSAKLVVMHSVQDGQADRREAPAGDIMDHIAAFFDARIAALTGAGIKRNRLVLDPGMGFFLGAAPETSLSVLARFDELRLRFDLPVLLSVSRKSFLRALTGRGPGDVGAATLAAELAAAAGGADFIRTHEPRPLRDGLAVLAALKETARIR MNKSLIIFGIVNITSDSFSDGGRYLAPDAAIAQARKLMAEGADVIDLGPASSNPDAAPVSSDTEIARIAPVLDALKADGIPVSLDSYQPATQAYALSRGVAYLNDIRGFPDAAFYPQLAKSSAKLVVMHSVQDGQADRREAPAGDIMDHIAAFFDARIAALTGAGIKRNRLVLDPGMGFFLGAAPETSLSVLARFDELRLRFDLPVLLSVSRKSFLRALTGRGPGDVGAATLAAELAAAAGGADFIRTHEPRPLRDGLAVLAALKETARIR 100.00 gnl|BL_ORD_ID|877|hsp_num:0 952 Z1_01607 HTH-type transcriptional regulator CueR Loose 290 76.6 golS 36.52 3000504 protein homolog model n/a n/a monobactam; carbapenem; cephalosporin; cephamycin; penam; phenicol antibiotic; penem antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MRIGQLAQLVGVETQTIRFYEQQGLLPPPDRQDNGYRVYTEKHGEGLAFIRRCRILGLSLAEVHELQSYQDDPHQPCTAVNALLDDHISHVRSQITALQALEKQLVSLRASCNDDREVEACGVLAGISEGNMHQQ MNIGKAAKASKVSAKMIRYYEQIGLIPAASRTDSGYRAYTQADVNQLHFIRRARDLGFSVAEISDLLNLWNNQSRQSADVKRLAQTHIDELDRRIQNMQHMAQTLKALIHCCAGDALPDCPILHTLGQPDDSEPEARTGAVLRRPRRHGLAKRL 87.66 gnl|BL_ORD_ID|36|hsp_num:0 44 Z1_01609 Tetracycline resistance protein, class C Strict 500 748.0 tet(C) 99.49 3000167 protein homolog model n/a n/a tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MKSNNALIVILGTVTLDAVGIGLVMPVLPGLLRDIVHSDSIASHYGVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATIDYAIMATTPVLWILYAGRIVAGITGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGAISLHAPFLAAAVLNGLNLLLGCFLMQESHKGERRPMPLRAFNPVSSFRWARGMTIVAALMTVFFIMQLVGQVPAALWVIFGEDRFRWSATMIGLSLAVFGILHALAQAFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRDWMAFPIMILLASGGIGMPALQAMLSRQVDDDHQGQLQGSLAALTSLTSIIGPLIFTAIYAASASTWNGLAWIVGAALYLVCLPALRRGAWSRATST MKSNNALIVILGTVTLDAVGIGLVMPVLPGLLRDIVHSDSIASHYGVLLALYALMQFLCAPVLGALSDRFGRRPVLLASLLGATIDYAIMATTPVLWILYAGRIVAGITGATGAVAGAYIADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGAISLHAPFLAAAVLNGLNLLLGCFLMQESHKGERRPMPLRAFNPVSSFRWARGMTIVAALMTVFFIMQLVGQVPAALWVIFGEDRFRWSATMIGLSLAVFGILHALAQAFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRGWMAFPIMILLASGGIGMPALQAMLSRQVDDDHQGQLQGSLAALTSLTSIIGPLIVTAIYAASASTWNGLAWIVGAALYLVCLPALRRGAWSRATST 100.00 gnl|BL_ORD_ID|895|hsp_num:0 900 Z1_01613 hypothetical protein Strict 300 317.0 dfrA32 99.36 3004555 protein homolog model n/a n/a diaminopyrimidine antibiotic antibiotic target replacement trimethoprim resistant dihydrofolate reductase dfr MPRASKQQARYAVGRCLMLWSSNDVTQQGSRPKTKLAISGVKLKISLISAVSENGVIGSGPDIPWSAKGEQLIFKALTYNQWLLVGRKTFDSMGVLPNRKYAVVSKNGISGSNENVLVFPSIENALQELSKITDHVYISGGGQIYESLIEKADIIHLSTIHVEVEGDIKFPILPEGFNLVFEQFFVSNINYTYQIWKKG MKISLISAVSENGVIGSGPDIPWSAKGEQLIFKALTYNQWLLVGRKTFDSMGVLPNRKYAVVSKNGISGSNENVLVFPSIENALQELSKITDHVYISGGGQIYESLIEKADIIHLSTIHVEVEGDIKFPILPEGFNLVFEQFFVSNINYTYQIWKKG 126.75 gnl|BL_ORD_ID|2718|hsp_num:0 3263 Z1_01614 hypothetical protein Strict 650 782.3 EreA 98.77 3000361 protein homolog model n/a n/a macrolide antibiotic antibiotic inactivation macrolide esterase MTWRTTRTLLQPQNLDFNEFEILTSVIEGARIVGIGEGAHFVAEFSLARASLIRYLVERHDFNAIGLECGAIQASRLSEWLNSTAGAHELERFSDTLTFSVYGSVLIWLKSYLRESGRKLQLVGIDLPNTLNPRDDLAQLAEIIQLIDHLMKPHVDMLTHLLASIDGQSAVISSAKWGELETARQEKAISGVTRLKLRLASLAPVLKKHVNSDLFRKASDRIESIEYTLETLRIMKTFFDGTSLEGDTSVRDSYMAGVVDGMVRANPDVKIILLAHNNHLQKTPVSFSGELTAVPMGQHLAERVNYRAIAFTHLGPTVPEMHFPSPDSPLGFSVVTTPADAIREDSMEQYVIDACGTENSCLTLTDAPMEAKRMRSQSASVKTKLSEAFDAIVCVPSAGKDSLVAL MTWRTTRTLLQPQKLDFNEFEILTSVIEGARIVGIGEGAHFVAEFSLARASLIRYLVERHEFNAIGLECGAIQASRLSEWLNSTAGAHELERFSDTLTFSVYGSVLIWLKSYLRESGRKLQLVGIDLPNTLNPRDDLAQLAEIIQLIDHLMKPHVDMLTHLLASIDGQSAVISSAKWGELETARQEKAISGVTRLKLRLASLAPVLKKHVNSDLFRKASDRIESIEYTLETLRIMKTFFDGTSLEGDTSVRDSYMAGVVDGMVRANPDVKIILLAHNNHLQKTPVSFSGELTAVPMGQHLAERVNYRAIAFTHLGPTVPEMHFPSPKSPLGFSVVTTPADAIREDSMEQYVIDACGTENSCLTLTDAPMEAKRMRSQSASVETKLSEAFDAIVCVTSAGKDSLVAL 100.00 gnl|BL_ORD_ID|920|hsp_num:0 991 Z1_01615 Streptomycin 3''-adenylyltransferase Perfect 450 515.8 aadA2 100.0 3002602 protein homolog model n/a n/a aminoglycoside antibiotic antibiotic inactivation ANT(3'') MTIEISNQLSEVLSVIERHLESTLLAVHLYGSAVDGGLKPYSDIDLLVTVAVKLDETTRRALLNDLMEASAFPGESETLRAIEVTLVVHDDIIPWRYPAKRELQFGEWQRNDILAGIFEPAMIDIDLAILLTKAREHSVALVGPAAEEFFDPVPEQDLFEALRETLKLWNSQPDWAGDERNVVLTLSRIWYSAITGKIAPKDVAADWAIKRLPAQYQPVLLEAKQAYLGQKEDHLASRADHLEEFIRFVKGEIIKSVGK MTIEISNQLSEVLSVIERHLESTLLAVHLYGSAVDGGLKPYSDIDLLVTVAVKLDETTRRALLNDLMEASAFPGESETLRAIEVTLVVHDDIIPWRYPAKRELQFGEWQRNDILAGIFEPAMIDIDLAILLTKAREHSVALVGPAAEEFFDPVPEQDLFEALRETLKLWNSQPDWAGDERNVVLTLSRIWYSAITGKIAPKDVAADWAIKRLPAQYQPVLLEAKQAYLGQKEDHLASRADHLEEFIRFVKGEIIKSVGK 100.00 gnl|BL_ORD_ID|1129|hsp_num:0 1227 Z1_01619 HTH-type transcriptional regulator CueR Loose 290 77.0 golS 37.39 3000504 protein homolog model n/a n/a monobactam; carbapenem; cephalosporin; cephamycin; penam; phenicol antibiotic; penem antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MRIGQLAQLVGVETQTIRFYEQQGLLPPPDRQDNGYRVYTEKHGEGLAFIRRCRILGLSLAEIHELQSYQDDPHQPCTAVNALLDDHISHVRSQITALQALEKQLVSLRASCNDDREVEACGVLAGISEGNMHQQ MNIGKAAKASKVSAKMIRYYEQIGLIPAASRTDSGYRAYTQADVNQLHFIRRARDLGFSVAEISDLLNLWNNQSRQSADVKRLAQTHIDELDRRIQNMQHMAQTLKALIHCCAGDALPDCPILHTLGQPDDSEPEARTGAVLRRPRRHGLAKRL 87.66 gnl|BL_ORD_ID|36|hsp_num:0 44 Z1_01646 Peptide chain release factor RF3 Loose 1350 175.6 Staphylococcus aureus fusA with mutation conferring resistance to fusidic acid 28.18 3003735 protein variant model H457Q fusidane antibiotic antibiotic target alteration antibiotic resistant fusA MANQDFLNEINKRRTFAIISHPDAGKTTITEKVLLFGQAIQRAGTVKGRGSNQHAKSDWMEMEKQRGISITTSVMQFPYADCLVNLLDTPGHEDFSEDTYRTLTAVDCCLMVIDSSKGVEDRTRKLMEVTRLRDTPILTFMNKLDRDIRDPMELMDEVETELKIACSPVTWPIGCGKLFKGVYHILRDETYLYQTGQGHTIQNSRVIKGLDNPELDEAIGDDLAVQLRDELELVLGASHEFDHEAFLAGELTPVFFGTALGNFGVNHMLDGLVKWAPAPMPRQTDMREVTAAEETFTGFVFKIQANMDPKHRDRVAFLRVVSGMYDKGMKLHQVRTKKDVVISDALTFMAGDRSHVEHAYPGDIIGLHNHGTIQIGDTFTQGEMLKFTGIPNFAPELFRRIRLRDPLKQKQLLKGLVQLSEEGAVQVFRPLANNDLIVGAVGVLQFDVVVARLKGEYNVEAIYESVNVSTARWVECSNEKKLEEFKRKNEQHLALDGGDNLTYIAPTMVNLNLTRERYPDIEFHQTREH MAREFSLEKTRNIGIMAHIDAGKTTTTERILYYTGRIHKIGETHEGASQMDWMEQEQDRGITITSAATTAAWEGHRVNIIDTPGHVDFTVEVERSLRVLDGAVTVLDAQSGVEPQTETVWRQATTYGVPRIVFVNKMDKLGANFEYSVSTLHDRLQANAAPIQLPIGAEDEFEAIIDLVEMKCFKYTNDLGTEIEEIEIPEDHLDRAEEARASLIEAVAETSDELMEKYLGDEEISVSELKEAIRQATTNVEFYPVLCGTAFKNKGVQLMLDAVIDYLPSPLDVKPIIGHRASNPEEEVIAKADDSAEFAALAFKVMTDPYVGKLTFFRVYSGTMTSGSYVKNSTKGKRERVGRLLQMHANSRQEIDTVYSGDIAAAVGLKDTGTGDTLCGEKNDIILESMEFPEPVIHLSVEPKSKADQDKMTQALVKLQEEDPTFHAHTDEETGQVIIGGMGELHLDILVDRMKKEFNVECNVGAPMVSYRETFKSSAQVQGKFSRQSGGRGQYGDVHIEFTPNETGAGFEFENAIVGGVVPREYIPSVEAGLKDAMENGVLAGYPLIDVKAKLYDGSYHDVDSSEMAFKIAASLALKEAAKKCDPVILEPMMKVTIEMPEEYMGDIMGDVTSRRGRVDGMEPRGNAQVVNAYVPLSEMFGYATSLRSNTQGRGTYTMYFDHYAEVPKSIAEDIIKKNKGE 76.33 gnl|BL_ORD_ID|4704|hsp_num:0 2254 Z1_01664 C4-dicarboxylate transport transcriptional regulatory protein DctD Loose 400 42.4 Pseudomonas aeruginosa CpxR 32.0 3004054 protein homolog model n/a n/a macrolide antibiotic; fluoroquinolone antibiotic; monobactam; aminoglycoside antibiotic; carbapenem; cephalosporin; cephamycin; penam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; penem antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MTQSLLSDIDILLIDDDEDILESYRHLLNLAGMVARVTDSPEKALSLLTPEYEGAVVLDIYMPAMNGMEVLARIQQIDPRIPVITVIYPLL MSELLLIDDDRELCELLGTWLVQEGFSVRASHDGAQARRALAEQTPDAVVLDVMLPDGSGLELLKQLRGDHPDLPVLMLSARGEPLDRILGLELGADDYLAKPCDPRELTARLRAVLRRTHPAQPSAQMQLGDLSLNLTRGVAQIDGQEISLTLSESRILEALLRQPGEPLDKQALAQLALGRKLTLYDRSLDMHVSNLRKKLGSHPDGSPRILALRGRGYYYSH 40.44 gnl|BL_ORD_ID|2308|hsp_num:0 2685 Z1_01665 C4-dicarboxylate transport transcriptional regulatory protein DctD Loose 400 89.7 TxR 26.62 3005008 protein homolog model n/a n/a tetracycline antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MITTTQERLVGDSAQITAIRQQVQQIADIDKDLMIEGEMGTGRHLLAQLLHELSPHSDKAVTTVDCQNLVDIKPLIAQIEQEEVGTLILRSPYDLPSGAQRWLSAYLLDMERQGKRQFRTIAILENNTQQLVTEGRLIPEFYYYFSQITFSLPPLSARRPDIIPLFRAFLRQSAQRLGIAVPKIDRNYLDILKRYDWPGNIRELRNVAELYAVGIVKMVDSEQHRAIIPPEGPLDNLVDDYERRLIEDALYLFAGRVSDVADYLGIPRKKLYLRMKKHELDKESYKPKV MKVQKCKATIHRRSLDADPLLPLIGNSTCISELRNKLKKYAQCDAEVLIQGETGVGKGMCARIIHELSSRHIYPFVEVNCGAIPSGLIASELFGHEKGAFTGAISDRIGFIQKANKGTLFLDEIGDMPPDLQIHLLHFLESKQIHKVGADKIIDVDCRVIAASHVDLKSEVIQGGFREDLFYRQNILPLTIPPLRKRGEDTVILSERFLEELSNGKVQSMSPEVKKKLLKHKWPGNVRELRNVIQRAIVMCEDNTLHIADLGLDNNERQLLPSVEQIDLDYLLKAIEDNKHNMSAAARNLGISRTTLYRLIKKYNLPI 90.88 gnl|BL_ORD_ID|4730|hsp_num:0 3753 Z1_01671 Tetracycline resistance protein, class B Strict 250 369.0 tet(D) 53.79 3000168 protein homolog model n/a n/a tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MNKSIIIILLVTVLDAIGIGLIMPVLPTLLNEFVSENRLANHYGILLALYATMQVIFAPILGKLSDKYGRKPILLFSLLGAALDYLLMACSTSLWMLYIGRIIAGITGATGAVCASAMTDVTHPHERTRYFGFLGGAFGVGLIIGPMLGGLLGEISAHTPFIFAAISHSLLFIFSLLCFQETQTTKISTEISALNQDTAPHSATGFIKKSLCFWLIAYFIIQLIGQIPATIWVLFTQVRFAWHTTEVGLSLAFLGVLHIFFQAVLAGKLAQKWGERNTVIISMSIDAFGCLLLAWISHVWVMLPALICLAVGGMGQPALQGYLSKSVDHHVQGQLQGTLVSLTNITGIVGPLLFSFIYSYSVEYWDGLLWFIGAMLYSGLLVASYFKQKSPILKKFPS MNKPAVIALVITLLDAMGIGLIMPVLPSLLREYLPEADVANHYGILLALYAVMQVCFAPLLGRWSDKLGRRPVLLLSLAGAAFDYTLLALSNVLWMLYLGRIISGITGATGAVAASVVADSTAVSERTAWFGRLGAAFGAGLIAGPAIGGLAGDISPHLPFVIAAILNACTFLMVFFIFKPAVQTEEKPAEQKQESAGISFITLLKPLALLLFVFFTAQLIGQIPATVWVLFTESRFAWDSAAVGFSLAGLGAMHALFQAVVAGALAKRLSEKTIIFAGFIADATAFLLMSAITSGWMVYPVLILLAGGGIALPALQGIISAGASAANQGKLQGVLVSLTNLTGVAGPLLFAFIFSQTQQSADGTVWLIGTALYGLLLAICLLIRKPAPVAATC 101.02 gnl|BL_ORD_ID|1190|hsp_num:0 1138 Z1_01720 Outer membrane protein TolC Loose 900 569.7 TolC 67.26 3000237 protein homolog model n/a n/a macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; rifamycin antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump MKKLLSLLVTMSLAGFSTASQAEDLLQVYQKAKDSNPELRKSLAERNQAFEKINEARSPLLPQLGLGASIDYKSGYRDAKNTESNSLGANLTLTQTIFDMSLWRQLTMQEKTAGMSDVTYQTSQQQLILDTATAYFNVLRAIDSLSFIEAQKEQVYRQLDQTTQRFNVGLVAITDVQNARANYDSVLAQEVAGRNELDNALEKLRQVSGVYYINLASLNIARFSTTPPDAIDKLLKDAEERNLSLLSARLGQDLARENIRLAQSGHLPTVNLNASTGVSNSHNHGSALPPETPANSRNSYNGQSSIGLSLSIPLYTGGRTSSQVEQAQYGFTSASEQLESVYRSIVQIARSSYNNISASISSIKAYQQVVVSAQSSLDATEAGYQVGTRTIVDVLNATTTLYDAKQKLSSARYDYLINQLNIQYARGTLNENDLIQLNNALGEEISTSPDNIIRPLTSPVLNTTN MQMKKLLPILIGLSLSGFSSLSQAENLMQVYQQARLSNPELRKSAADRDAAFEKINEARSPLLPQLGLGADYTYSNGYRDANGINSNATSASLQLTQSIFDMSKWRALTLQEKAAGIQDVTYQTDQQTLILNTATAYFNVLNAIDVLSYTQAQKEAIYRQLDQTTQRFNVGLVAITDVQNARAQYDTVLANEVTARNNLDNAVEQLRQITGNYYPELAALNVENFKTDKPQPVNALLKEAEKRNLSLLQARLSQDLAREQIRQAQDGHLPTLDLTASTGISDTSYSGSKTRGAAGTQYDDSNMGQNKVGLSFSLPIYQGGMVNSQVKQAQYNFVGASEQLESAHRSVVQTVRSSFNNINASISSINAYKQAVVSAQSSLDAMEAGYSVGTRTIVDVLDATTTLYNAKQELANARYNYLINQLNIKSALGTLNEQDLLALNNALSKPVSTNPENVAPQTPEQNAIADGYAPDSPAPVVQQTSARTTTSNGHNPFRN 93.94 gnl|BL_ORD_ID|4685|hsp_num:0 826 Z1_01730 IS1595 family transposase ISSsu9 Loose 300 145.2 dfrA3 48.15 3003105 protein homolog model n/a n/a diaminopyrimidine antibiotic antibiotic target replacement trimethoprim resistant dihydrofolate reductase dfr MNISLIAALAADRIIGMEKAMPWTLPGDLAWFKKNTLNKPVIMGRVTYESIGRPLPNRLNIVLSSQPGNDDNVVWVKSVEEALQAAENNDEIMVIGGGKVYEQFLPMANKLYLTHIDAEVIGDTTFPDYEPDEWDSTFMEYHEADENNSHNYCFEILKRRK MLISLIAALAHNNLIGKDNLIPWHLPADLRHFKAVTLGKPVVMGRRTFESIGRPLPGRRNVVVSRNPQWQAEGVEVAPSLDAALALLTDCEEAMIIGGGQLYAEALPRADRLYLTYIDAQLNGDTHFPDYLSLGWQELERSTHPADDKNSYACEFVTLSRQR 99.38 gnl|BL_ORD_ID|471|hsp_num:0 511 Z1_01733 Ribosomal RNA small subunit methyltransferase A Loose 400 83.2 ErmE 30.85 3000326 protein homolog model n/a n/a macrolide antibiotic; lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; streptogramin B antibiotic antibiotic target alteration Erm 23S ribosomal RNA methyltransferase MNNRVHQGHFARKRFGQNFLTDSYIIESIVESIYPQPGEAVIEIGPGLGALTEPVGERMDKMTVVEIDRDLAARLEVHPTLKDKLTIIQQDAMTIDFAQLAKERQQPLRVFGNLPYNISTPLMFHLFSFADAISDMTFMLQKEVVNRLVASHGSKTYGRLSVMAQYHCQVIPIIEVPPSSFKPAPKVDSAVVRLIPYKEKPYPVTDIAMLSRITAQAFNQRRKTLRNSLGGLLTAEDMLALDIDPTARAENISVEQYCKVANWLSSQQQHAE MSSSDEQPRPRRRNQDRQHPNQNRPVLGRTERDRNRRQFGQNFLRDRKTIARIAETAELRPDLPVLEAGPGEGLLTRELADRARQVTSYEIDPRLAKSLREKLSGHPNIEVVNADFLTAEPPPEPFAFVGAIPYGITSAIVDWCLEAPTIETATMVTQLEFARKRTGDYGRWSRLTVMTWPLFEWEFVEKVDRRLFKPVPKVDSAIMRLRRRAEPLLEGAALERYESMVELCFTGVGGNIQASLLRKYPRRRVEAALDHAGVGGGAVVAYVRPEQWLRLFERLDQKNEPRGGQPQRGRRTGGRDHGDRRTGGQDRGDRRTGGRDHRDRQASGHGDRRSSGRNRDDGRTGEREQGDQGGRRGPSGGGRTGGRPGRRGGPGQR 71.39 gnl|BL_ORD_ID|95|hsp_num:0 109 Z1_01736 LPS-assembly protein LptD Loose 1500 951.0 LptD 58.06 3005059 protein homolog model n/a n/a carbapenem; peptide antibiotic; aminocoumarin antibiotic; rifamycin antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MKKSYPTLLATLVWATIYAQPAYADLASQCLLGVPVYNKPLVEGDPNSLPVTITAKDMQGEYPRMIQYRGNVDIKQGNQTLSADNVELTQTEGETPLRMVTATGNVSYDDPQIILKGPRAWSNLNNKDTDIEEGKYQMVGRQGRGYANKMQMRGENRYTIMDKGMFTSCLPGDDSWSVVGSEVILDREEQVAEIWNARFRVANVPVFYSPYLQLPIGDKRRSGFLIPNGNYSRSSGFDFQLPYYWNIAPNYDATITTNYISRRGLKLDNEFRYLTKPGRGTIAVDWINHDSQYNKDKADEKAGYLARDSATRWLFYWGHSGVMNNVWRFNVDYTKVSDNKYFTDFTSQYGNTTDGYATQKFSTGYAQQNWNATLTTKQFQIFSDNKDARAYRAEPQLDLNYYKNDIGPFDFRTYAQFVRFTSVGENTPEANRYHIEPTISLPASTGWASFNNEFKLMATHYDQDIPDAYKKKYPHQKLDDSVNRVLPQFKSDMKVVFERQYDTNDITQTLEPRVQYLYVPYKDQSNINNFDSALLQSNYSGLFRDRMYGGLDRIASANQLTAGVTSRFYDSELVERFNISVGQIYFFERPKTGSSNEIINSKDETGSMVWAGDAYWRITDTLGMRGGLQYDRRLGSVSMGDAIMEYRRDSDHLLQLSYRYVDRDYIQATRVRPYDGGVNQLPEYQKGISQIGVVGSWPLAERWGLVGAYYFDTKDSEPVSQMVGLQYNTCCWAVNVGYERKIVGWKEDHSDIDNKWSINLELRGLSNNHSLGSQKMLERGILPYQRAF MKKRIPSLLATMIASALYSQQGLAADLATQCMLGVPSYDRPLVEGRPGDLPVTINADHAKGNYPDNAVFTGNVDINQGNSRLRADEVQLHQQQAAGQAQPVRTVDALGNVHYDDNQVILKGPKAWSNLNTKDTNVWQGDYQMVGRQGRGTADLMKQRGENRYTILENGSFTSCLPGSDTWSVVGSEVIHDREEQVAEIWNARFKLGSVPIFYSPYLQLPVGDKRRSGFLIPNAKYSTKNGVEFSLPYYWNIAPNFDATITPHYMNKRGGVMWENEFRYLTQLGSGLTEFDYLPSDKVYEDDHSSDSNSRRWLFYWNHSGVIDQVWRLNADYTKVSDPDYFNDFSSKYGSSTDGYATQKFSAGYVNQNFDATVSTKQFQVFDRESSNSYSAEPQLDVNYYQNDVGPFDTHLYGQVAHFVNSNNNMPEATRVHFEPTINLPLSNGWGSLNTEAKLLATHYQQSNLDKYNAANGTDYKESVSRVMPQFKVDGKMVFERDLQEGFTQTLEPRVQYLYVPYRDQSEIGNYDSTLLQSDYTGLFRDRTYSGLDRIASANQVTTGLTSRVYDAAAVERFNISVGQIYYFTESRTGDDNINWENNDTTGSLVWAGDTYWRIADEWGLRGGIQYDTRLDNVATGNGTIEYRRDENRLVQLNYRYASPEYIQATLPSYSTAAQYKQGISQVGMTASWPIVDRWSVVGAYYYDTNTRKAANQMLGVQYNSCCYAIRLGYERKVNGWNSNDNGGESKYDNTFGINIELRGLSSNYGLGTQQMLRSNILPYQSSL 100.77 gnl|BL_ORD_ID|2793|hsp_num:0 3799 Z1_01743 Thiamine import ATP-binding protein ThiQ Loose 500 100.5 RanA 29.31 3005091 protein homolog model n/a n/a aminoglycoside antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MIKLEQLTYTYEHQHLTFNLTVKAGERIAILGPSGAGKSSLLSLIAGFLPSESGSLFLKGKDHTKTAPAQRPISMLFQDNNLFPHLTVRQNIGLGLDPGLKLTVAQKALLESRAKQVSLSDYLERLPSQLSGGQRQRVAIARCLVREQPILLLDEPFSALDPALRIEMLTLLEQICDEKNLTLLMVSHSLEDAHKIAPRALVIDNGTIVYDGNTASLIKGEVDQSLLLGIPFN MIEVKDLRKSFNDVEVLKGITTTFETGKINLVIGQSGSGKTVFLKCLLNVFDPSSGDILFDGRNLSIMGRTEKQEIRSEIGTVFQGSALFDSMTVEENISFPLDMFTNLTYTEKRKRVKEVIGRVHLENANTKFPSEISGGMQKRVAIARAIVNNPKYLFCDEPNSGLDPNTAIVIDELIKEITEEYNTTTIINTHDMNSVLTIGEKIVYLRKGVKEWEGNKDLIIKAENEHLIDFVYSSALFKQVRETMLRNNQTNL 90.31 gnl|BL_ORD_ID|2817|hsp_num:0 3825 Z1_01769 Glycine cleavage system transcriptional activator Loose 550 153.3 NmcR 33.56 3003665 protein homolog model n/a n/a carbapenem; cephalosporin; cephamycin; penam antibiotic inactivation NmcA beta-lactamase MSKRLPPLNALRVFDSAARHLSFTKAAEELFVTQAAVSHQIKTLEEFLGLKLFRRRNRSLLLTEEGQSYYLDIKEIFSSINEATRKLLARSAKGALTVSLSPSFAIQWLVPRLSGFNQAYPGIDVRIQAVDREEDKLADDVDVAIFYGRGNWTGLRTDRLYAEYLIPVCAPSLLTGEKPLKTPSDLIYHTLLHDTSRRDWQAYVRQLEIQNQINVQQGPIFSHSSMVIQAAVHGQGVALVNNVMARSEIESGRLVRPFQDVLVSKNAFYLVCQDSQAELGKIAAFRQWILSQAANEQEKLGLLATS MRARLPLNALRAFEASARYLNFTKAGLELHVSQAAVSQQVRTLEQMLGVALFTRVPRGLQLTDEGMHLLPSITEALQMMSSAMDKFHEGKIKEVLTIAVVGTFAIGWLLPRITAFLNENPWIDIRILTHNNVVNLAAEGIDASIRFGTGGWINTENILLFQAPHTVLCSPETSKKLYIPSDLKKVCLLRSYRKEEWNNWFKAAGIDPWTITGPIFDSTRLMIDAVKLGDYAALVPYHMFQKELNERSVAKPFEIYATLGGYWLTLQKSRVNHNSEALNVFKEWIIEHSREFVLKS 103.73 gnl|BL_ORD_ID|1908|hsp_num:0 2072 Z1_01811 Methionine import ATP-binding protein MetN Loose 1280 151.4 macB 36.13 3000535 protein homolog model n/a n/a macrolide antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MIKLTNINKVFKQGARSIQALSNINLHVPQGQIFGVIGSSGAGKSTLIRCVNMLEKPTSGEVWVDGRDLTKLSDKELTKARRGIGMIFQHFNLLSSRTVFDNVALPLELDNTPRADINKRVNELLELVGLADKKEYYPANLSGGQKQRVAIARALANSPNVLLCDEATSALDPATTRSILELLKDINRRLGLTILLITHEMDVVKRICDQVAVISGGQLVESDAVSEVFSHPKTPVSQAFIQSTLQLDIPDDYKERMKPEWEEGLFPLLKLEFNGLSVDAPLMSIVARRFDADINILSSQMDYAGGVKFGVMLAELHGKNGNTEKSIAFLEEHHVKVEVLGYV MSLIECKNINRYFGSGENRVHILKDISLSIEKGDFVAIIGQSGSGKSTLMNILGCLDTAGSGSYRIDGIETAKMQPDELAALRRERFGFIFQRYNLLSSLTARDNVALPAVYMGMGGKERSARADKLLQDLGLASKEGNKPGELSGGQQQRVSIARALMNGGEIIFADEPTGALDTASGKNVMEIIRRLHEAGHTVIMVTHDPGIAANANRVIEIRDGEIISDTSKNPEIPASNVGRIQEKASWSFYYDQFVEAFRMSVQAVLAHKMRSLLTMLGIIIGIASVVSVVALGNGSQKKILEDISSMGTNTISIFPGRGFGDRRSGKIKTLTIDDAKIIAKQSYVASATPMTSSGGTLTYRNTDLTASLYGVGEQYFDVRGLKLETGRLFDENDVKEDAQVVVIDQNVKDKLFADSDPLGKTILFRKRPLTVIGVMKKDENAFGNSDVLMLWSPYTTVMHQITGESHTNSITVKIKDNANTRVAEKGLAELLKARHGTEDFFMNNSDSIRQMVESTTGTMKLLISSIALISLVVGGIGVMNIMLVSVTERTKEIGIRMAIGARRGNILQQFLIEAVLICIIGGLVGVGLSAAVSLVFNHFVTDFPMDISAASVIGAVACSTGIGIAFGFMPANKAAKLNPIDALAQD 53.26 gnl|BL_ORD_ID|447|hsp_num:0 487 Z1_01830 Sulfate adenylyltransferase subunit 1 Loose 300 58.5 tet(S) 31.45 3000192 protein homolog model n/a n/a tetracycline antibiotic antibiotic target protection tetracycline-resistant ribosomal protection protein MGLAAIKTNQLIAGEIAQSGGVENYLKTQQNKGLLRFLTCGNVDDGKSTLIGRLLHDTRQIYEDQLSTLQNESKKIGTQGEKLDLALLVDGLAAEREQGITIDVAYRYFSTAKRKFIIADTPGHAQYTRNMATGASTSTLSILLIDARKGVQEQTRRHSFISTLLGIRHLVVAINKMDLLDYQQEIFESIQQDYLHFAQQLPRDLTIEFVPISALEGDNVVSPSLNMPWYTGKTLLALLEDAPVKFKLGAKSQRLRFPVQYVNRPDLDFRGYSGTVSSGSLYQGQQIKVLPSGQRSTIKRIVTFDGDLTQAQVGQAITLVLADEIDISRGDIIVDANDTTANVSNHALVDIVWMSEQPLVQGQTLDIKVAGKKSRAKIENIHYQVDVDKLTQQVTESLALNAIGHVEVLFEEPLVLDNYQLNAQTGGLIFIDRLSNVTVGAGLIREIRDNEQPTTSQYDAFEIELNQLIRRHFPHWGARDLLGGK MKIINIGILAHVDAGKTTLTESLLYSSGAIKELGSVDSGTTKTDTMFLERQRGITIQTAITSFQRENVKVNIVDTPGHMDFLADVYRSLSVLDGAILLISAKDGVQSQTRILFHALRKMNIPIIFFINKIDQNGINLPDVYQDIKDKLSDDIIIKQTVNLNLKPYVIDYTEPEQWETVIVGNDYLLEKYTIGKTLNIAELEKEENERIQSCSLYPVYHGSAKNNIGIKQLIEVITSKLFSPTQLNSDKLCGNVFKVEYSDDGQRLVYVRLYSGTLHLRDSVNISEKEKIKVTEMYTSINGELRQIDKAEPGEIIILKNELLKLNNVLGDKKRLPHREILENPLPMLQTTIEPCKSVQREKLLDALFEISDSDPLLQYYVDTVTHEIVLSFLGEVQMEVTCTLIQEKYHIEIETRKPTVIYMERPLKKSEFTIDIEVPPNPFWASIGLSVTPLPLGSGIQYESLVSLGYLNQSFQNAVMEGIRYGCEQGLYGWKLTDCKICFKYGLYYSPVSTPADFRMLAPIVLEQAFRKSGTELLEPYLSFEIYVPQEYLSRAYNDASKYCANILNTKLKGNEVILIGEIPARCIQEYRNSLTFFTNGRSVCLTELKGYQVTNIKSAFQPRRPNNRIDKVRHMFNKINLH 75.66 gnl|BL_ORD_ID|1527|hsp_num:0 1553 Z1_01864 HTH-type transcriptional regulator DmlR Loose 650 121.7 adeL 29.25 3000620 protein homolog model n/a n/a fluoroquinolone antibiotic; tetracycline antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MKYDLNDLYYFVKVVEFGGFSQAAETLGIPKSKLSRRIADLEERLKVSLIYRSTRQFHVTKIGQTFYQQCKNVVEQAEIAQEVICSAQGHPHGTIKLSCPVALLQIYIQDILVDFMAKYPDINIQILAINRPVDVISEGLDLALRVRALPLDDSGLTMKILGYSRRVLVANPLLFATNSAPDSPEQLADYPILANSEHSQQYTLTLTHNDGTVSTQHVTPKLATTDVMTLYKATLKGLGITRLPLSVVEKELADGSLVEVLPQWRFPKDVIHAVYPSRKGLLPAIQVLLDYLAQNMAPYKE MRVFNKVVETNSFSLAADSLGLPRASVTTTIQALEKHLQVRLLNRTTRKISLTPDGAVYYDRTARILADVADIESSFHDAERGPRGQLRIDVPVSIGRLILIPRLRDFHARYPDIDLVIGLNDRPVDLVGEAVDCAIRVGELKDSSLIARRIGTFQCATAASPIYLEKYGEPTSIEDLQKNHKAIHFFSSRTGRNFDWDFVVDDLIKSVSVRGRVSVNDGDAYIDLALQGFGIIQGPRYMLTNHLESGLLKEVLPQWTPAPMPISAVYLQNRHLSLKVKVFVDWVAELFAGCPLLGGTALPFDQKCEFACDKETGHEYTIRTLVEQHNIAEAYTLKT 89.32 gnl|BL_ORD_ID|2323|hsp_num:0 2654 Z1_01871 putative galactarate transporter Loose 750 69.7 blt 22.86 3003006 protein homolog model n/a n/a fluoroquinolone antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MNDAQVNESKGKVPYWVKLTIIFFFGWIALYGSRAIVGPLMVNIGAEFDLTKAQLGSIMSIFFIGYTALNIPSGIIGDYLGKKKVLVTGVVLFGGFTIIAGMMPTYVTFMFAWVMVGVFQGFYYGPQYGLSSEAIPKHRITLGSAIINSGMAFGLSIGYYISSISVGEMGMSWRAPFYIIGVPIIIIGLMMLWIIKDKPKTKATDMAPNAPKQKTKLTFKDLFGNRNINLAYITIFCSIYGFFVLVTWLPYYLETERGITGTQISTIASLMPWFAIPGSLLFSWFSDKLGRRKPVLLIMLPLSLVAILAVPMSDSMPVLIGALILYGIVGKISTNPVLVAVVADNSPRHALGTSFGVYNCIGMLGSVFAPTLTGFLSDKTGSMDSGFYFAAILICIGIVASLFIKENPDATATN MKKSINEQKTIFIILLSNIFVAFLGIGLIIPVMPSFMKIMHLSGSTMGYLVAAFAISQLITSPFAGRWVDRFGRKKMIILGLLIFSLSELIFGLGTHVSIFYFSRILGGVSAAFIMPAVTAYVADITTLKERSKAMGYVSAAISTGFIIGPGAGGFIAGFGIRMPFFFASAIALIAAVTSVFILKESLSIEERHQLSSHTKESNFIKDLKRSIHPVYFIAFIIVFVMAFGLSAYETVFSLFSDHKFGFTPKDIAAIITISSIVAVVIQVLLFGKLVNKLGEKRMIQLCLITGAILAFVSTVMSGFLTVLLVTCFIFLAFDLLRPALTAHLSNMAGNQQGFVAGMNSTYTSLGNIFGPALGGILFDLNIHYPFLFAGFVMIVGLGLTMVWKEKKNDAAALN 103.50 gnl|BL_ORD_ID|1828|hsp_num:0 1975 Z1_01872 HTH-type transcriptional activator AllS Loose 650 47.0 adeL 26.32 3000620 protein homolog model n/a n/a fluoroquinolone antibiotic; tetracycline antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MLDQEMIRTFIQVADCQSFTKAAEMLHKTSAAISYRIKTLEENIGTQLFNRTTRTVTLTPAGEYLLEKCRQWIVWLESMPIELQQMNAGVEHQVNIVINNLLYDRTAVASMLACLHQRFPSTQFHITRQVYMGVWDALINEDYHFAIGVTGNESLKNNINICAMGEIQWQFVVAPNHPLANVSGVLSDDQMRIYSAVNVEDTSRHLSKRTAWRLSGQHEIKVPDLHTKLACHLKGVGIGFLPLSLCKPLIDSGQLIAKEVKNRRHNSPLSLAWCEDKKGAVVSYLVDLFRQGHPSVQSFYDPLN MRVFNKVVETNSFSLAADSLGLPRASVTTTIQALEKHLQVRLLNRTTRKISLTPDGAVYYDRTARILADVADIESSFHDAERGPRGQLRIDVPVSIGRLILIPRLRDFHARYPDIDLVIGLNDRPVDLVGEAVDCAIRVGELKDSSLIARRIGTFQCATAASPIYLEKYGEPTSIEDLQKNHKAIHFFSSRTGRNFDWDFVVDDLIKSVSVRGRVSVNDGDAYIDLALQGFGIIQGPRYMLTNHLESGLLKEVLPQWTPAPMPISAVYLQNRHLSLKVKVFVDWVAELFAGCPLLGGTALPFDQKCEFACDKETGHEYTIRTLVEQHNIAEAYTLKT 90.21 gnl|BL_ORD_ID|2323|hsp_num:0 2654 Z1_01877 Response regulator protein TmoT Loose 390 47.0 evgA 24.32 3000832 protein homolog model n/a n/a macrolide antibiotic; fluoroquinolone antibiotic; penam; tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump MESIIHLITFEDDSTKVQLKAVLSSLAANVKTYSNEQAFLKYYFSSTKGAHKECIIINTKSSASPSIALVKELNKLKNIIPVIIISGDASIESCRNAFKAGAFEYLTRPLNVNELLNIVSESFLHYESEVEQFRTYISLKDKFSKLSNREKEVMEMILDGNTSKEAAEKLSLSPRTVEVHRSNMYTKLKIRSLPQLVQEYDFFKKYDLRAN MNAIIIDDHPLAIAAIRNLLIKNDIEILAELTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQVLETLRKRQYSGIIIIVSAKNDHFYGKHCADAGANGFVSKKEGMNNIIAAIEAAKNGYCYFPFSLNRFVGSLTSDQQKLDSLSKQEISVMRYILDGKDNNDIAEKMFISNKTVSTYKSRLMEKLECKSLMDLYTFAQRNKIG 103.43 gnl|BL_ORD_ID|939|hsp_num:0 1015 Z1_01888 Putative cation/proton antiporter YbaL Loose 1080 660.6 rosB 66.19 3003049 protein homolog model n/a n/a peptide antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MPHSTPLITTIVGGLALAYILGMIAQRLKISPLVGYLAAGVLAGPFTPGFVADTSLAPELAEIGVILLMFGVGLHFSLKDLMAVKAIAIPGAIAQITVATLLGLGLSTFFGWGLFSGIVFGLCLSTASTVVLLRALEERGLIDSQRGQIAIGWLIVEDLAMVLALVLLPAIANMLESSDQTSISQLLINLGITIGKVVAFILIMMIVGRKLIPWILAKTAATGSRELFTLCVLALALGIAYAAVTLFDASFALGAFFAGMVLNESDLSHRAAQDTLPLRDAFAVLFFVSVGMLFDPMVLIEHPLGILATLAIIIIGKSLAALVLVRMFGHSRRTALTISASLAQIGEFAFILAGMGVALNVLEPDARNLVLAGALVSIMLNPVLFSLLDRYLAKTETKEEQEQLQQEEMEEEMPVPVDICGHAIIVGYGRAGSMLAEKLQPQAIPLVIIENSRNKFAELKEKGLNAVLGNAMTKESLALARVDCAKSLLLTIPNGYEAADIAETARKMNPDLNIIVRAHFDDIIVRANYDEEASFILEKGANHVIIDEDQTASAMAEMLIQEVEFGCTIDDTPEEGQQIIAPNAAQ MHHSTPLITTIVGGLVLAFLLGSLAHRLRSSPLVGYLAAGVLAGPFTPGFVADTSLAPELAEIGVILLMFGVGLHFSLKDLLAVKAIAIPGAVAQIAVATLLGMGLSHLLGWDLMTGFVFGLCLSTASTVVLLRALEERQLIDSQRGQIAIGRSIVEDLAMVLTLVLLPAFAGVMGNETTSLSQLFTELAITIGKVIAFITLMIVVGRRLVPWILAKTASTGSRELFTLAVLVLALGIAYGAVGLFDVSFALGAFFAGMVLNESELSHRAAQDTLPLRDAFAVLFFVSVGMLFDPMILLREPLAVLASLAIIIFGKSAAAFILVRMFGHSNVYSTHHFCPWRKSVNLPFILAGLGISLGLMSEHGRNLVLAGAILSIMLNPLLFTLLDRYLAKNETMEDLILEEAVEEEKQIPGRFVQSCTVSRLWSGGSLLGAKLHAEGIPLVVIENSRPRVEALREQGINAVLGNAASADIMSLARLDCALVIILTIPNGYEAGEIVASARIKRPDLEIIARAHYDDEVVYISVRGANQVVMGEREIANSMLNMLKIETLTEEDKRPLCPI 104.09 gnl|BL_ORD_ID|467|hsp_num:0 507 Z1_01896 HTH-type transcriptional regulator CueR Loose 290 87.8 golS 36.51 3000504 protein homolog model n/a n/a monobactam; carbapenem; cephalosporin; cephamycin; penam; phenicol antibiotic; penem antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MNISEIATKTGLTTKAIRFYEEKDLITPPHRGENGYRYYLPQHIEELTLLKQAREVGFSLEECRSLLMLLRNPSRHSADVKEATLKKVAEIEKTINELNAIRQRLLLLANECPGDDGAECPIINHLSGCCHHQ MNIGKAAKASKVSAKMIRYYEQIGLIPAASRTDSGYRAYTQADVNQLHFIRRARDLGFSVAEISDLLNLWNNQSRQSADVKRLAQTHIDELDRRIQNMQHMAQTLKALIHCCAGDALPDCPILHTLGQPDDSEPEARTGAVLRRPRRHGLAKRL 86.36 gnl|BL_ORD_ID|36|hsp_num:0 44 Z1_01902 Lipoprotein-releasing system ATP-binding protein LolD Loose 1280 164.1 macB 38.81 3000535 protein homolog model n/a n/a macrolide antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MSTEKVLEVHQLTKQVGEGDSQISILQGVELVVESAQTIALIGESGSGKSTLLGIIAGLDDGGAGHVQLMGHDLTEMNEEERAKLRAQHVGFVFQSFMLIPTLNALENVQLPALLKGESEKQSHTRAVDLLKQLGLGERLYHMPAQLSGGEQQRVALARAFCTQPAILFADEPTGNLDRKTGDKIADLLFSLNRDYATTLILVTHDNELAARCQRRLRLVDGQLKEES MSLIECKNINRYFGSGENRVHILKDISLSIEKGDFVAIIGQSGSGKSTLMNILGCLDTAGSGSYRIDGIETAKMQPDELAALRRERFGFIFQRYNLLSSLTARDNVALPAVYMGMGGKERSARADKLLQDLGLASKEGNKPGELSGGQQQRVSIARALMNGGEIIFADEPTGALDTASGKNVMEIIRRLHEAGHTVIMVTHDPGIAANANRVIEIRDGEIISDTSKNPEIPASNVGRIQEKASWSFYYDQFVEAFRMSVQAVLAHKMRSLLTMLGIIIGIASVVSVVALGNGSQKKILEDISSMGTNTISIFPGRGFGDRRSGKIKTLTIDDAKIIAKQSYVASATPMTSSGGTLTYRNTDLTASLYGVGEQYFDVRGLKLETGRLFDENDVKEDAQVVVIDQNVKDKLFADSDPLGKTILFRKRPLTVIGVMKKDENAFGNSDVLMLWSPYTTVMHQITGESHTNSITVKIKDNANTRVAEKGLAELLKARHGTEDFFMNNSDSIRQMVESTTGTMKLLISSIALISLVVGGIGVMNIMLVSVTERTKEIGIRMAIGARRGNILQQFLIEAVLICIIGGLVGVGLSAAVSLVFNHFVTDFPMDISAASVIGAVACSTGIGIAFGFMPANKAAKLNPIDALAQD 35.40 gnl|BL_ORD_ID|447|hsp_num:0 487 Z1_01997 Prophage bactoprenol glucosyl transferase Loose 550 160.6 PmrF 33.98 3003578 protein homolog model n/a n/a peptide antibiotic antibiotic target alteration pmr phosphoethanolamine transferase MKISLVVPVFNEEEAIPIFYKTVRENEELKKYDVEIIFINDGSKDSTENIINALSLADEQVIALSFTRNFGKEPALFAGLDHATGEAIIPIDVDLQDPIEVIPQLIEKWKQGADVVLAKRTDRSTDGWLKRKTAEWFYKLHNKISTPKIEENVGDFRLMSRETVENIKLLPERNLFMKGVLSWVGGKVDIVEYSRAERSAGESKFNGWKLWNLALEGITSFSTFPLRMWTYIGLFVGAISFVYGGWMIIDKLIWGNPVPGYPSLLVSILFLGGIQLIGIGVLGEYIGRIYVESKQRPKYILKARK MFEIHPVKKVSVVIPVYNEQESLPELIRRTTTACESLGKEYEILLIDDGSSDNSAHMLVEASQAENSHIVSILLNRNYGQHSAIMAGFSHVTGDLIITLDADLQNPPEEIPRLVAKADEGYDVVGTVRQNRQDSWFRKTASKMINRLIQRTTGKAMGDYGCMLRAYRRHIVDAMLHCHERSTFIPILANIFARRAIEIPVHHAEREFGESKYSFMRLINLMYDLVTCLTTTPLRMLSLLGSIIAIGGFSIAVLLVILRLTFGPQWAAEGVFMLFAVLFTFIGAQFIGMGLLGEYIGRIYTDVRARPRYFVQQVIRPSSKENE 94.72 gnl|BL_ORD_ID|1940|hsp_num:0 2014 Z1_02072 Peptidoglycan D,D-transpeptidase FtsI Strict 500 564.3 Haemophilus influenzae PBP3 conferring resistance to beta-lactam antibiotics 51.45 3004446 protein variant model D350N cephalosporin; cephamycin; penam antibiotic target alteration Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics MKFSRSAKAKTKTKSNAKLRKPEEKTGFVSWRFALLCGGIGIALAALLIRVAYLQIINPDPLIREGDLRSLRVQKVPTARGMISDRMGRPLAVSVPVYAIWADPKVVLEANPDMTDSRWLALADALKLPVNQISQKISATPSARFIYLARQVNPEISDYISKLKIKGINMRQESKRYYPSGEVTAHIIGVTNIDGDGIEGVEKSFNQWLTGAPGERVVRKDGFNRVIENIAQTDSQAAHNLMLSIDERLQSVVYRELTNAVIENKAESGTAVLVDVNTGEVLAMANSPSYNPNNLAGTPKDAMRNRAITDIFEPGSTVKPMVVMSALNNNIIKENTVINTVPYRISGHQIKDVALYRELSITGILQKSSNVGVSRLALAMPASELVDVYSRFGLGKPTNLGLVGESSGIFPIKKQRWSDLERATFSFGYGLMVTPLQLARVYATIGSFGIYRPLSITKVDPPVPGTRVFPEKVMRTVVHMMESVALPGGGGVRAAIKGYRVAIKTGTAKKVGPDGKYINAYISYAAGVAPASRPRFALVVIINEPKAGKYYGGAVSAPVFGTIMGAVLRTMNVEPDALTPDDKSEIVINKKEDTSGRS MVKFNSSRKSGKSKKTIRKLTAPETVKQNKPQKVFEKCFMRGRYMLSTVLILLGLCALVARAAYVQSINADTLSNEADKRSLRKDEVLSVRGSILDRNGQLLSVSVPMSAIVADPKTMLKENSLADKERIAALAEELGMTENDLVKKIEKNSKSGYLYLARQVELSKANYIRRLKIKGIILETEHRRFYPRVEEAAHVVGYTDIDGNGIEGIEKSFNSLLVGKDGSRTVRKDKRGNIVAHISDEKKYDAQDVTLSIDEKLQSMVYREIKKAVSENNAESGTAVLVDVRTGEVLAMATAPSYNPNNRVGVKSELMRNRAITDTFEPGSTVKPFVVLTALQRGVVKRDEIIDTTSFKLSGKEIVDVAPRAQQTLDEILMNSSNRGVSRLALRMPPSALMETYQNAGLSKPTDLGLIGEQVGILNANRKRWADIERATVAYGYGITATPLQIARAYATLGSFGVYRPLSITKVDPPVIGKRVFSEKITKDIVGILEKVAIKNKRAMVEGYRVGVKTGTARKIENGHYVNKYVAFTAGIAPISDPRYALVVLINDPKAGEYYGGAVSAPVFSNIMGYALRANAIPQDAEAAENTTTKSAKRIVYIGEHKNQKVN 98.03 gnl|BL_ORD_ID|2504|hsp_num:0 2886 Z1_02112 HTH-type transcriptional regulator ArgP Loose 550 49.3 NmcR 30.97 3003665 protein homolog model n/a n/a carbapenem; cephalosporin; cephamycin; penam antibiotic inactivation NmcA beta-lactamase MKRPDYRALQALDAVIRERGFERAAQKLCITQSAVSQRIKQLENLFGQPLLVRTVPPQPTEQGQKLLALLHQVEMLEEQWLGDENSGSTPLLLSLAVNADSLATWLLPALHPVLTQLPIRLNIQVEDETRTQERLRRGEVVGAISIQPQALPSCLVDQLGALDYLFVASPDFAQRYFANGVTKSSLLKAPAVAFDHLDDMHQAFLQQNFGLSPGSVPCHIVNSSEAFVQLAKQGSTCCMIPHLQIADELKSGELIDLTPGLCQRRMLYWHRFAPESRTMRKVTDALLDYGRKVLKQDEE MRARLPLNALRAFEASARYLNFTKAGLELHVSQAAVSQQVRTLEQMLGVALFTRVPRGLQLTDEGMHLLPSITEALQMMSSAMDKFHEGKIKEVLTIAVVGTFAIGWLLPRITAFLNENPWIDIRILTHNNVVNLAAEGIDASIRFGTGGWINTENILLFQAPHTVLCSPETSKKLYIPSDLKKVCLLRSYRKEEWNNWFKAAGIDPWTITGPIFDSTRLMIDAVKLGDYAALVPYHMFQKELNERSVAKPFEIYATLGGYWLTLQKSRVNHNSEALNVFKEWIIEHSREFVLKS 101.36 gnl|BL_ORD_ID|1908|hsp_num:0 2072 Z1_02114 D-3-phosphoglycerate dehydrogenase Loose 200 118.2 vanH gene in vanB cluster 33.09 3002943 protein homolog model n/a n/a glycopeptide antibiotic antibiotic target alteration vanH; glycopeptide resistance gene cluster MVKVSLEKEKIKFLLLEGVHQSAVENLRAAGYTNIEYHKGALSGEELKQAIRDARFVGIRSRTHLTEEIFAAAEKLVAVGCFCIGTNQVDLDAAARRGIPVFNAPFSNTRSVAEMVLGELLLLLRRIPEANAKAHRGIWDKQAKGCFEARGKKLGIIGYGHIGTQLGILAESVGLDVYFYDIENKLPLGNATQIRHLSELLNMCDIVSLHVPETPSTKNMIGHEELLRMKPGAILINASRGTVVDIPALAQALESKHLSGAAVDVFPTEPGANNDPNDPFVSELIKFDNVILTPHIGGSTQEAQENIGYEVAGKLAKYSDNGSTLSAVNFPEVSLPSHGDDVNRLLHIHENRPGIMNSINNVFTEENINVAAQYLRTAGNVGYVVIDVATQTKAQAELVLQKLKGLPGTIRARMLY MRKSMGITVFGCEQDEANAFRTLSPDFHIIPTLISDAISADNAKLAAGNQCISVGHKSEVSEATILALRKVGVKYISTRSIGCNHIDTTAAERMGISVGTVAYSPDSVADYALMLMLMAIRGAKSTIHAVAQQNFRLDCVRGKELRDMTVGVIGTGHIGQAVVKRLRGFGCRVLAYDNSRKIEADYVQLDELLKNSDIVTLHVPLCADTRHLIGQSEIGEMKQGAFLINTGRGALVDTGSLVEALGSGKLGGAALDVLEGEDQFVYTDCSQKVLDHPFLSQLLRMPNVIITPHTAYYTERVLRDTTEKTIRNCLNFERSLQHE 128.79 gnl|BL_ORD_ID|4682|hsp_num:0 626 Z1_02115 Alpha-hemolysin translocation ATP-binding protein HlyB Loose 750 235.7 patB 30.67 3000025 protein homolog model n/a n/a fluoroquinolone antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MNYITKNTPSLHPSIIDGLIYFSKKNKGTLKKEQLIHFLGNDDNLSELNIIEAAQQLNLKCEFSFFNSESEYKDKIIIDTLIEINGYWYILKNRISDKLIIIDPSTNTESHYHIDKKITYTTLLIINKIFTPKQSKFSLMWCIPSLLKQKKSLYLIFILSCFIQLFALVNPIILEKIIDKVLTGRSLSNLQVLGVLLVLLAIIEPIYLLLRDKLYAFVSCTLGAEFSGKIYQHLIRLPSQFFNQRQSGQIIARIQELAHIRQFITGSALMMVLDFIFIIVFLSVMFAYSVLLTWITIAALVVYFLFWLILGPMIRYWVEQEYQANADNTSLLTEAINGIETIKITATEHQFIEKWQYKLTNYILKRFSAAKKALFAQQLIGAIHKITMAIILWHGVNLIMKAQLSVGELVAFNMFATHITQPILRLAQLWQDIQQTGISIRRIGEIVNTPTEHQHQGLATVPNIAGSIVFSHVRFRYTANTPDVIEQLSFSIPAGKFIGITGPSGSGKSTITRLIQRFYTPQQGQIYIDGMDLAIANPLTLRQSISVVLQDNFLFSGTIMENIRLSKPDCSEEDIIEASKLAGAFHFITQLPEGFNTQVGERGSNLSGGQRQRIALARALLPDPRILILDEATSALDYASEAEILANLPAICKNRTVICIAHRLNAISISDYIYVINKGRILEEGTHSDLLNKKTLYQQLWQQQTQQ MKTVQFFWHYFKVYKFSFVVVILMIVLATFAQALFPVFSGQAVTQLANLVQAYQNGNPELVWQSLSGIMVNLGLLVLVLFISSVIYMCLMTRVIAESTNEMRKGLFGKLAQLTVSFFDRRQDGDILSHFTSDLDNILQAFNESLIQVMSNIVLYIGLILVMFSRNVTLALITIASTPLAFLMLIFIVKMARKYTNLQQKEVGKLNAYMDESISGQKAVIVQGIQEDMMAGFLEQNERVRKATFKGRMFSGILFPVMNGMSLINTAIVIFAGSAVLLNDKSIETSTALGLIVMFAQFSQQYYQPIIQVAASWGSLQLAFTGAERIQEMFDAEEEIRPEKAPTFTKLQESVEISHIVFSYLPDKPILKDVSISAPKGQMTAVVGPTGSGKTTIMNLINRFYDVDAGGIYFDGKDIRGYDLDSLRSKVGIVLQDSVLFSGTIRDNIRFGVPDASQEMVEVAAKATHIHDYIESLPDKYDTLIDDDQSIFSTGQKQLISIARTLMTDPEVLILDEATSNVDTVTESKIQHAMEVVVAGRTSFVIAHRLKTILNADQIIVLKDGEVIERGNHHELLKLGGFYSELYHNQFVFE 120.24 gnl|BL_ORD_ID|1914|hsp_num:0 2112 Z1_02117 Toxin RTX-I translocation ATP-binding protein Loose 1190 236.5 novA 29.28 3002522 protein homolog model n/a n/a aminocoumarin antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MKNRESTKFIKSINIILNLSGKQLDNTKPNINKYDDTIASLEKKHAFKLKKKNIHYIFKKQLHYPMIFLDRSKNIFILLKYNNNEFLIYNLQTDNMETWNKERLINNSINHYYYLDFAEKHFFDITWFVPTFMKYRILFQSVLFYSLILQLLALASPIITQIIMDKVIIHQALSTLDVLIIGLIFVAVSESVLKGIREYIYHHTANKIDMLLSLKLTNHLFKLPISYFKSRQTGIIVTRVKELDIIREFITKTLLMLLVDFSFIFIFLFVMAYLSLKLTLIFLATIPLYFILAKLIAPKIEKTVQQLYQYSATNSAFLTETLGGIETIKSLSLEPRFTQQWHTQIHQLTNENLKLQNIDNLSQYIVSFLQKITTAILLCLGAFEVISLAMTIGQLIAFNMLLNHCLQPLSSAIEVWGKYIRAKTAIYNLQDILNLPIEQEKANKKMTLQGEVSFENVSFSYQHDAPPVVRQISFRINKYETIGIVGTSGSGKSTLARIIAGLYIPQLGQVKLDGIPVCEIPPAVLRQQIGFVLQENFLFHLTVLDNIRLTQPSASLDDVIHVAKLAGAHEFILKLPLGYDTLIAENGRSLSGGQCQRIAIARALLSSPKILIFDEATSALDGESQAIIEKNLPLITQDKTVIMIAHRLSTIKNCDRIIVLEKGQIIEEGKHNELIRKDGAYKKLWQHQQG MKSALSTWKPSDRPPDPTLPEPPAQLRRIFRLFRPYRGRLAVVGLLVGASSLVAVASPFMLREILDTAIPQGRTGLLSLLALGMILTAVLSSVFGVVQTLISTTVGQRVMHDLRTAVYAQLQRMPLAFFTRTRTGEVQSRIANDIGGMQATVTSTATSLVSNLTAVIATVVAMLALDWRLTVVSLLLLPVFVWISRRVGRERKRITLQRQKQMATMAATVTESLSVSGILLGRTMGRADSLTRSFAEESERLVDLEVRSNMAGRWRMSVIGIVMAAMPAVIYWAAGFVLQSGGTVVSIGTLVAFVSLQQGLFRPAVSLLATGVQMQTSLALFQRIFEYLDLPVDITEPERPVALDKVRGEVRFDGVDFSYEEKDGNTLHGLDLTVPAGGSLAVVGPTGSGKSTLSYLVPRLYDVTGGRVLLDGVDVRDLAFDTLARAVGVVSQETYLFHASVADNLRFAKPDATDEEIEKAARAAQIHEHIVTLPDGYDTLVGERGYRFSGGEKQRLAIARTILRDPPVLVLDEATSALDTRTEHAVQQAIDSLSEGRTTITIAHRLSTVRDADQIVVLDAGRIAERGTHEELIDRDGRYAALVRRDGAPAPAPVPARDERVGAA 112.20 gnl|BL_ORD_ID|1115|hsp_num:0 1210 Z1_02122 2-octaprenyl-6-methoxyphenol hydroxylase Loose 750 51.6 tet(54) 23.28 3004590 protein homolog model n/a n/a tetracycline antibiotic antibiotic inactivation tetracycline inactivation enzyme MNVIIVGGGMAGATLALALSALNKGNISISLIEAREPDNGHPGFDARAIALAHGTAKRLAQIGLWSVLKPFVTPINHVHISDRGHCGFVNINAQDYDIDALGYVIELHDAGRQLFAQLKKQPNITLYCPAKVEHVQRHLDNVEVTLDDGTQLSGDLLVAADGTHSPIGHQCHIQWQKTPYHQVAVIANVKTEIDPKGCAFERFTQFGPLAMLPMSEGRSSLVWCHPIEKLEQVSQWDDQTTIAQLQRDFGWRLGKIEQVGQRHCYPLVLQKAQQMISHRLALIGNASQTLHPIAGQGFNLGLRDVMTLANTLTTAIQSGRDIGSYRVLSQYQQLREQDRESTITITDGLVKVFANRCMPLIISRNLGLMTMELVPALRNKLAHQTLGWTN MSTIKKILVIGAGIAGTAVCYWLRRFGFYPVLIEKSACIRKGGQGLDIRGVAIDIVKKMVIYEQICKMRTQVECGRYVDVVGKTLHEEKGEKFAFRQDEDVEILRGDLIEILMKTIDDVPCHFNQSIDSIEQNDDDVIVYFKDARVEHYDLIIGADGIHSSIRRMVFDKDEYRLVNLAEAYFSIFSIPNYLNLSHTEVQCETNEKLVSITSDKDPKTAQVAFMFRSQHVWNNLRDEHEQMQFLRDIFHDFGWEAQKILELMPNSHDFYFDSVTQVKMRSWTKGQVALVGDASYSASPLSGQGNNLALVGAYILAGELKAAEGNYRLAFNRYNELLHPFVEANQQLGAWVSESFLVPDAVSKEVAEERSNRILQKVQIISNAIKLPEYE 100.52 gnl|BL_ORD_ID|2735|hsp_num:0 3292 Z1_02123 2-octaprenylphenol hydroxylase Loose 600 67.0 Streptomyces venezuelae rox 24.14 3007209 protein homolog model n/a n/a rifamycin antibiotic antibiotic inactivation rifampin monooxygenase MKSFDVVIAGGGMVGLALACGLHGCGLRIAIIENHPVTTHFHPQDDFALRVSAINTASELLLKKLGVWENLTALRTAPYQGMEVWDQDSFGRIAFSAQQEGLSHLGTIIENHLIREVLWQKVTSHSDITCYSPAQIERIVWGENEAFISLNDGEMLTARLVVGADGANSWLRKNADIPLTFWDYEHHALVATIRTEQPHDNVARQVFHGEGILAFLPLADPHTCSIVWSLPSSLAEDYKSADKTRFERTLGVTFDMCLGQCELVSERMTIPLTGRYARQFAAPRLALLGDAAHTIHPLAGQGVNLGFMDVAELIGEIRRLKAEGKDFGEYLYLRRFERRRKHAAAVMLATMQGFRELFEGNNPIKKWVRDIGLSLADSLPGVKPKLLEQAMGLSDLPEWLKHKNSVSAEKI MFDVIVVGGGPTGLMLAGELRLHGVRVLVLEKETEPTRQSRAQGLHVRSIEVMAQRGLLERFLERGHTVAVGGFFAGLATSWPERLDTAHSYVLAVPQVITEQLLAEHATALGAEIRRGRALVGLRQDEDGVTVDLADGEQLRARYVVGCDGGRSTVRKLLGVAFPGEPSRVETLLGEMEMTASQEELTSVMTEVRKTQQRFGAMPLGDGVFRVVVPAEGVAEDRTASPTLDEFKQQLRAHAGTDFGVHSPRWLSRFGDATRQAERYRVDRVFLAGDAAHIHPPTGGQGLNLGIQDAFNLGWKLAAEVDGWAPEGLLDTYHAERHPVATEVLDNTRAQIQLMSTEPGPQAVRRLMAELVEFENVNRYLIEKITAISVRYDVGEGHELLGRRMRDLALKHGRLYERMHEGRGLLLDQTGRLSVAGWEDRVDHVVEVSEELDVPAVLLRPDGHVVWAGEDQQELLTRMPAWFGAATAG 86.34 gnl|BL_ORD_ID|4836|hsp_num:0 5820 Z1_02165 Glyoxylate/hydroxypyruvate reductase B Loose 200 110.9 vanH gene in vanO cluster 32.56 3002948 protein homolog model n/a n/a glycopeptide antibiotic antibiotic target alteration vanH; glycopeptide resistance gene cluster MKPVVILYQPLPEKLQQKLSAVAEVKQFNALSLDCADFKATLAHAEGLLGAGGNIDKHFIEKAPKLKAVSTISVGYDNVDVAALTERHIKLMHTPTVLTDTVADTMMALVLTVSRRIPELADNIKQGLWVKSITPDWYGTDVHHKTMGIIGMGRIGKALAQRAHFGFDMDIIYHSRTEYNDVNQHFNAKFCSLEMLLQQADFVCITLPLTPETHHLLSAKQFALMKADAYLINAGRGAVVDEKALINALEQRQIAGAGLDVFEQEPLPTSSPLLTMKNVVALPHIGSATKETRYAMAECAVDNLIAALTDNVKENCVNF MSYRDLGLIDSEVIAERRVRALDDSSPSAVPTTGVRVFGCGHDEAVLFREMGTRLGITPSITEEAISETNAELARGNRCISVSHKTQIDNSTLLALSRVGVEYISTRSVGYNHIDVEFAASIGISVGNVDYSPDSVGDYTLMLMLMTVRHAKSIVRRADTHDYRLNDTRGRELRDLTVGVIGTGRIGTAVIDRLQGFGCRVLAHDSGPHASADYVPLDELLRQSDIVTLHTPLTADTHHLLDRQRIDQMKHGAYIVNTGRGPLLDTEALLSALESGRLGGAALDVVEGEEGIFYADCRNRLIENKALVRLQRLPNVLISPHSAYYTDHALNDTVENSLVNCLNFESGRTA 91.14 gnl|BL_ORD_ID|762|hsp_num:0 786 Z1_02185 Inner membrane transport protein YdhP Loose 700 159.8 cmlv 30.14 3002700 protein homolog model n/a n/a phenicol antibiotic antibiotic inactivation chloramphenicol phosphotransferase MKAFFPLFALATGAFAIGATEFTPMGLLPNIANGLSISIATAGGLITGYAVGVMIGAPIMTLSLGKLTKRHALGLLLLLFIAGNLLAAQADSYWSLMIARLITSLNHGAFFGIGSVVAASLVEKHKQASAVAAMFMGLTIANLVGVPLVTWIGQQYGWRLAFILISGLGFITLIGLLMFLPVMPKGNKPNIKYELGVLTRLPVVLALLTTVFGASALFALYTYIAPFLTNTVHISESHVAVVLVIIGLGFTIGNYLGGKLSSYGIEKTLILFFILLIGSMSVLPLVSNNVYLAVATIFIWSISSFALVPALQIKTMQIAHDAPALVSSVNIGAFNLGNAIGAIIGGIALKYSYNIVPLTAALVGVIGLLLVYSQIKIKKSFSSECCVNSL MPSPSAEPTTSTPTPDAGPAASPRMPLAVYILGLSAFALGTSEFMLSGLVPPIAEDMNVSIPRAGLLISAFAIGMVVGAPLLAVATLRLPRKTTLIALITVFGLRQMAGALAPNYAVLFASRVISALPCAGFWAVGAAVAIAMVPVGSRARALAVMIGGLSIANVLRVPAGAFLGEHLGWASAFWAVGLASAIALVGVVTRIPRIPLPETRPRPLKNEVAIYRDRQVLLSIAVTALAAGGVFCAFSYLAPLLTDVSGLDEAWVSGVLGLFGIGAVVGTTIGGRVADAHLFGVLLTGISASTVFLVALALFASNPAATIVLTFLLGVSAFYTAPALNARMFNVAGAAPTLAGATTTAAFNLGNTGGPWLGGTVIDANLGFASTAWAGAAMTVLGLGTAALALRLTKRPAPGHVVARSRGAGGTTPSEPARGKATSSC 89.45 gnl|BL_ORD_ID|650|hsp_num:0 703 Z1_02226 Elongation factor 4 Loose 400 104.4 tetB(P) 35.43 3000195 protein homolog model n/a n/a tetracycline antibiotic antibiotic target protection tetracycline-resistant ribosomal protection protein MKNIRNFSIIAHIDHGKSTLSDRIIQICGGLTDREMAAQVLDSMDLERERGITIKAQSVTLNYTADDGEVYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAGQGVEAQTLANCYTAIDMDLTVVPVLNKIDLPAAEPERVAEEIEDIVGIDATDAVRCSAKTGVGVKEVIERLVKEIPAPEGDPDAPLQALIIDSWFDNYLGVVSLIRIKNGKVNKGDKIKVMSTGQVYNIDRIGIFTPKQVDTTSLSCGEVGWVVCGIKDILGAPVGDTLTAAQKPADKPLPGFKKVKPQVYAGLFPVSSDDYESFRDALGKLSLNDASLFYEPESSSALGFGFRCGFLGLLHMEIIQERLEREYDLDLITTAPTVVYEVEMTNGDIIMVDSPSKLPALNNIEEIREPIAECHMLLPQEYLGNVITLCVEKRGVQTNMVYHGNQVSLTYEIPMAEVVLDFFDRLKSTSRGYASLDYNFLRFQGSNMVRVDVLINGERVDALALITHNDNAPYRGRELVEKMKEFIPRQQFDIAIQAAIGNHIIARSTVKQLRKNVLAKCYGGDVSRKKKLLQKQKEGKKRMKQIGNVELPQEAFLAILHVGKDK MKKIINIGIVAHVDAGKTTITENLLYYSGAIKSVGRVDLGNTQTDSMELERKRGITIKSSTISFNWNNVKVNIIDTPGHVDFISEVERSLNSLDGAILVISGVEGIQSQTRILFDTLKELNIPTIIFVNKLDRIGANFNKVFEEIKKNMSNKVVRLQEVYDVGSKAVYIKKLFDTCIINDDAINVLSDLDEAFLERYIGGIEPDKEEIQEKLSLYAREGSLYPVFCGAAAIGLGIEDLLDGICSYFPFASNDCESDLSGVVFKIERTSKNEKKVYVRLFGGKISVRDKIQVPNKEIAEKVKKINRLENGGVVEAQRIEAGDIGILYGLTSFQVGDVIGISNDKIKNISIAKPALKTTISAIDKEKNPELFKALTLLAEEDPLLAFAMNDIDKEIYVNLFGEVQMEILSSMLDDLYGIKVEFSNIETIYKETPKGFGASIMHMQEDLNPFWATVGLEIEPAGRGEGLRYISNVSVGSLPKSFQNAIEEAVIKTSKQGLFGWEVTDVKVTLSCGEFFSPASTPADFRNVTPMVFMEALYKAQTVLLEPLHEFELKIPQNALSKAVWDLETMRATFDNPIVIGDEFSIKGLIPVENSKEYKMKIASYTEGRGMFVTKFYGYKEASAEFSKARKKTTYDPLNKKEYLLHKLNAIRD 91.72 gnl|BL_ORD_ID|738|hsp_num:0 804 Z1_02242 Sensor histidine kinase GlrK Loose 850 85.5 baeS 27.24 3000829 protein homolog model n/a n/a aminoglycoside antibiotic; aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MISLKKWRIFPRSLRQLVIMAFWMVLLPLLVLAYQAYQSLDQLSNQAAITNKNALADTERSEVMRNLAIEMEGNYRRYCVLRDKTDEEMYQQRYQQYSKMFSTLQQTIIPLSESKEAQALNTSLKTLKSIQCKNSEPTSQMQQALEQFSYANNRIVVLTKEIIFSRGEQLQMAIAEKGRYFGWQSLIVFVFSLILIALFTRMIIGPVKGIEKMINRLGEGRTLNNNLNSFQGPRELRSLAQRIIWLSERLAWLESQRHEFLRHISHELKTPLASMREGTELLADEVAGPLTLDQKEVVAILDNSSKQLQLLIEQLLDYNRKLSEVPQQIEEVDLTTLVNDVVLAHSLPARAKGIKTIISLDLKKCRAETTLLSRVIDNLYSNAVHYGAESGNIWISSYQIEQKIVIDIANKGTPIPESEQKMIFEPFFQGSLLRKGAVKGSGLGLSIAHDCIKRMDGELNIVHSDYADVCFRIELPLLSENK MKFWRPGITGKLFLAIFATCIVLLISMHWAVRISFERGFIDYIKHGNEQRLQLLSDALGEQYAQHGNWRFLRNNDRFVFQILRSFEHDNSEDKPGPGMPPHGWRTQFWVVDQNNKVLVGPRAPIPPDGTRRPILVNGAEVGAVIASPVERLTRNTDINFDKQQRQTSWLIVALATLLAALATFLLARGLLAPVKRLVDGTHKLAAGDFTTRVTPTSEDELGKLAQDFNQLASTLEKNQQMRRDFMADISHELRTPLAVLRGELEAIQDGVRKFTPETVASLQAEVGTLTKLVDDLHQLSMSDEGALAYQKAPVDLIPLLEVAGGAFRERFASRGLKLQFSLPDSITVFGDRDRLMQLFNNLLENSLRYTDSGGSLQISAGQRDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERDLQREV 103.21 gnl|BL_ORD_ID|916|hsp_num:0 986 Z1_02244 Transcriptional regulatory protein QseF Loose 400 218.8 TxR 40.07 3005008 protein homolog model n/a n/a tetracycline antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MAGHKSANLLLVDDDPGLLKLLGMRLTSEGFHIVTAESGQEALKLLLKEKIDLVISDLRMDEMDGMALFAEIQRQQPGMPVIILTAHGSIPDAVAATQQGVFSFLTKPVDRDALYKAIDEALELVTTVSDEEWSKDIVTRSPQMLRLLEQAKLVAQSDVSVLINGQSGTGKEVLAQAIHRASPRAKKPFIAINCGALPEQLLESELFGHAKGAFTGAVSSREGLFQAAEGGTLFLDEIGDMPMALQVKLLRVLQERKVRPLGSNRDIDIDVRILSATHRDLPKAMERNEFREDLYYRLNVVNLRIPTLSERAEDIPVLANHLLRESAKRHKPFVRSFSTDAMKCLMTASWPGNVRQLVNVIEQCVALTTAPVISEALVTQALQGENTALPTFAEARGHFEMTYLRKLLQMTKGNVTQAARMAGRNRTEFYKLLSRHGLDANDFKE MKVQKCKATIHRRSLDADPLLPLIGNSTCISELRNKLKKYAQCDAEVLIQGETGVGKGMCARIIHELSSRHIYPFVEVNCGAIPSGLIASELFGHEKGAFTGAISDRIGFIQKANKGTLFLDEIGDMPPDLQIHLLHFLESKQIHKVGADKIIDVDCRVIAASHVDLKSEVIQGGFREDLFYRQNILPLTIPPLRKRGEDTVILSERFLEELSNGKVQSMSPEVKKKLLKHKWPGNVRELRNVIQRAIVMCEDNTLHIADLGLDNNERQLLPSVEQIDLDYLLKAIEDNKHNMSAAARNLGISRTTLYRLIKKYNLPI 139.94 gnl|BL_ORD_ID|4730|hsp_num:0 3753 Z1_02268 Dual-specificity RNA methyltransferase RlmN Loose 600 172.2 clbB 33.91 3002815 protein homolog model n/a n/a lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; oxazolidinone antibiotic; phenicol antibiotic; pleuromutilin antibiotic antibiotic target alteration Cfr 23S ribosomal RNA methyltransferase MTQSTTPAPSASVAVSKENTVNQKTKINLLDLNRKQMRELFVSMGEKPFRADQIMKWIYHYCYDDFDQMTDINKVLRAKLKEIAEIKAPEVSEEQRSADGTIKWAIKVGSQQVETVYIPEDDRATLCVSSQVGCALECKFCSTAQQGFNRNLKVSEIIGQVWRAAKIIGALKETGRRPITNVVMMGMGEPLLNLNNVIPALEIMMDDFGFGLSKRRVTVSTSGVVPALDKLADAVDVALAISLHAPTDDIRDEIVPINKKYNIEMFLDGVRRYIAKSNANQGRVTVEYVMLDHINDSTEQAHQLAECLKDTPCKINLIPWNPFPGAPYGRSSNSRIDRFSKVLMEYGFTTIVRKTRGDDIDAACGQLAGDVIDRTKRTLKKRLQGEPISVKAV MKLTSKYETIRRILSECKQPEYRYAQIMDAIFKQNIGEYERMTILPKFLRDELNRILGPNVCSIAPVKELTSKQVSKVLFAIPGDEQVEAVRLTYERGWKSYCISTQCGCGFRCKFCATGTIGLKRNLTADEITDQLLYFRLNGHSLDSISFMGMGEALANPHIFEAMTILTDPYLFGLGHRRITISTIGLLPGIDKLTREFPQVNLTFSLHSPFDDQRSELMPINDRFPVRDVLIALDRHIRETGRKVYIAYILLRGVNDSTAHAEAVAELLRGRGAWEHLYHVNLIPFNSTEVTPDSYRQSDPSRIKAFVRILKSRGISVTVRTQFGSDINAACGQLYRSE 114.58 gnl|BL_ORD_ID|110|hsp_num:0 127 Z1_02284 Sulfate/thiosulfate import ATP-binding protein CysA Loose 500 123.6 RanA 30.0 3005091 protein homolog model n/a n/a aminoglycoside antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MSIEINHVTKYFDRTEVLHDVNLTVNSGEMMALLGPSGSGKTTLLRIIAGLEHQTEGKICFAGQDVSRLHARERKVGFVFQHYALFRHMTVFENIAFGLSVLPRRERPNKAAINKKVTQLLEMIQLPHLAQRYPAQLSGGQKQRVALARALAVEPQILLLDEPFGALDAKVRTELRSWLRELHSELKFTSVFVTHDQQEAMEVADRIVIMGNGKIEQVGTPQQVWHTPESRFVLEFLGDVNHLQGEINGAQLQIAGYHLPLSVTPLYQGKVDVFLRPWEISLNPHSDSLCKLPVKVIEVTPKGHYWQLVLQPIEWGNTPISAVWNDMTSIPHKGDIYYMGGAKARLYAQERPLTTVSLAYTA MIEVKDLRKSFNDVEVLKGITTTFETGKINLVIGQSGSGKTVFLKCLLNVFDPSSGDILFDGRNLSIMGRTEKQEIRSEIGTVFQGSALFDSMTVEENISFPLDMFTNLTYTEKRKRVKEVIGRVHLENANTKFPSEISGGMQKRVAIARAIVNNPKYLFCDEPNSGLDPNTAIVIDELIKEITEEYNTTTIINTHDMNSVLTIGEKIVYLRKGVKEWEGNKDLIIKAENEHLIDFVYSSALFKQVRETMLRNNQTNL 140.31 gnl|BL_ORD_ID|2817|hsp_num:0 3825 Z1_02287 Phosphoenolpyruvate-protein phosphotransferase Loose 1100 873.6 Escherichia coli PtsI with mutation conferring resistance to fosfomycin 77.91 3003899 protein variant model V25I phosphonic acid antibiotic antibiotic target alteration antibiotic-resistant ptsI phosphotransferase MISGILASPGIAFGQALLLKEEPIIISQRKIQSDEVDTQIERFKDGRNKSAQQLEIIKARAEKNLGADKAEIFEGHIMLLEDEELEQEIISLIKSDKKTAEAAVQSVIEDQATALEALDDEYLKERAADVRDIGKRLMRNILEMPIIDLSAISEKVILVATDLTPSETAQLSLDNVLGFITDLGGRTSHTSIMARSLEIPAIVGTSNATETIKKEDYLVLDAINNKIIINPSDEELEALKAIKEEYLHEKEELAKLKDLPAITLDGHQVEVCANIGTVRDVAGAERNGAEGVGLYRTEFLFMDRDSLPTEEEQFQAYKAVAEAVGSPAVIIRTMDIGGDKDLPYMNLPKEENPFLGWRAIRICLDRKEILHPQLRAILRASAFGKLRIMFPMIISVEEIRALKAELEILKSQLREENKPFDESIEVGVMVETPAAAVMARHMAKEVDFFSIGTNDLTQYTLAVDRGNELISHLYNPMSPAVLNLIKQVIDASHAEGKWTGMCGELAGDERATMLLLGMGLDEFSMSAISIPRIKKIIRNANFDDAKALAEQALAQPTAKELMDLVETFTKEKTLC MISGILASPGIAFGKALLLKEDEIVIDRKKISADQVDQEVERFLSGRAKASAQLETIKTKAGETFGEEKEAIFEGHIMLLEDEELEQEIIALIKDKHMTADAAAHEVIEGQASALEELDDEYLKERAADVRDIGKRLLRNILGLKIIDLSAIQDEVILVAADLTPSETAQLNLKKVLGFITDAGGRTSHTSIMARSLELPAIVGTGSVTSQVKNDDYLILDAVNNQVYVNPTNEVIDKMRAVQEQVASEKAELAKLKDLPAITLDGHQVEVCANIGTVRDVEGAERNGAEGVGLYRTEFLFMDRDALPTEEEQFAAYKAVAEACGSQAVIVRTMDIGGDKELPYMNFPKEENPFLGWRAIRIAMDRREILRDQLRAILRASAFGKLRIMFPMIISVEEVRALRKEIEIYKQELRDEGKAFDESIEIGVMVETPAAATIARHLAKEVDFFSIGTNDLTQYTLAVDRGNDMISHLYQPMSPSVLNLIKQVIDASHAEGKWTGMCGELAGDERATLLLLGMGLDEFSMSAISIPRIKKIIRNTNFEDAKVLAEQALAQPTTDELMTLVNKFIEEKTIC 100.00 gnl|BL_ORD_ID|2464|hsp_num:0 2377 Z1_02295 hypothetical protein Loose 280 39.3 emrR 27.47 3000516 protein homolog model n/a n/a fluoroquinolone antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MEQLELENALSLLQCTLVAQRTRYTPEQVTWGQYDILELLRLRGDLTPSQLCEILAISRQNLSKFMRGLKSLGFIAQDRSKKDKRELITHLTDEGKAFLARAALGRKQNAQKLQAQLTPTEQAMFIELSHKVINALIADKLPTEPD MDSSFTPIEQMLKFRASRHEDFPYQEILLTRLCMHMQSKLLENRNKMLKAQGINETLFMALITLESQENHSIQPSELSCALGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHEFLREVLPPQHNCLHQLWSALSTTEKDQLEQITRKLLSRLDQMEQDGVVLEAMS 82.95 gnl|BL_ORD_ID|1228|hsp_num:0 1330 Z1_02328 hypothetical protein Loose 275 40.0 AAC(6')-Ia 37.93 3002545 protein homolog model n/a n/a aminoglycoside antibiotic antibiotic inactivation AAC(6') MTNASNKIATHEITIRPTQLADANQLPKIEQSAGELFSSIKELSWISESGVQSVEAHIQFIHQHAHWVAVNHDNHPVGFIMTQQLPESVFIHELSVSKDWQNKGIGKLLIQTVKNEAKLQQFNAVTLTTFRDVPWNAPYYQRLGFHILLEHQIPYSLQQILDNEVEHGGFAREMRCAMKCEI MNYQIVNIAECSNYQLEAANILTEAFNDLGNNSWPDMTSATKEVKECIESPNLCFGLLINNSLVGWIGLRPMYKETWELHPLVVRPDYQNKGIGKILLKELENRAREQGIIGIALGTDDEYYRTSLSLITITEDNIFDSIKNIKNINKHPYEFYQKNGYYIVGIIPNANGKNKPDIWMWKSLIKE 98.38 gnl|BL_ORD_ID|523|hsp_num:0 574 Z1_02332 HTH-type transcriptional regulator NimR Loose 470 40.4 gadW 36.84 3003838 protein homolog model n/a n/a macrolide antibiotic; fluoroquinolone antibiotic; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MTIEQQKEMQWLLSDPDTVRFRDEQLLAETEFRYHQHEFGQLLYVISGVMDLEAGGQRFLAPPEFSVWIPEKVGHASYNKKTLSFKVLDIAPSWCEGLLDKPCLIQLSPIFSTIFADFFRRGVCKPQTKEDLRLSQVLIDQLKVSPIHHTYLPSSKDKLLAPVLAALEQNPADNTSLELWAKKRYTSERTLSRRCQQELGMSFSEWRKRLRFLHAISLLEQGKSVNDVAFDVGYSSSSSFIAMFQQFAGTTPERFRRLPNG MAHVCSVILVRRSFDIHHEQQKISLHNESILLLDKNLADDFAFCSLDTRRLDIEELTVCHYLQNIRQLPRNLGLHSKDRLLINQSPPIQLVTAIFDSFNDPRVNSPILSKMLYLSCLSMFSHKKELIPLLFNSISTVSGKVERLISFDIAKRWYLRDIAERMYTSESLIKKKLQDENTCFSKILLASRMSMARRLLELRQIPLHTIAEKCGYSSTSYFINTFRQYYGVTPHQFSQHSPGTFS 107.85 gnl|BL_ORD_ID|2087|hsp_num:0 2324 Z1_02333 Erythronate-4-phosphate dehydrogenase Loose 200 104.8 vanH gene in vanB cluster 33.2 3002943 protein homolog model n/a n/a glycopeptide antibiotic antibiotic target alteration vanH; glycopeptide resistance gene cluster MKILVDENMPYAQQLFCQLGEVKAVPGRPLPIEELDDTDALMVRSITKVNASLLAGKPVKFVGTATAGFDHVDTAWLEQQKIAFSSAPGCNAIAVVEYVFSALMVFAEQEGFQLTDKTVGIVGVGNVGGRLAKRLRALGVNVLLCDPPRADRGDDEQFHSLETLLKQADILTFHTPLNKSGRYNSYHLINESNLDILPEGRILINASRGEVIDNAALLSALNQGKKLRVVLDVWEPEPDLSLELLNKVDIATPHIAGYTLEGKARGTTQVYEAYCDFIGQPQHVELSTLLPKPLISTISVQGELTQTLLKQLIHLVYDVRRDDAPLRKVAGIKGEFDKLRKFYPVRREWSSLQVVCDNPTTASLLNAIGFNATHK MRKSMGITVFGCEQDEANAFRTLSPDFHIIPTLISDAISADNAKLAAGNQCISVGHKSEVSEATILALRKVGVKYISTRSIGCNHIDTTAAERMGISVGTVAYSPDSVADYALMLMLMAIRGAKSTIHAVAQQNFRLDCVRGKELRDMTVGVIGTGHIGQAVVKRLRGFGCRVLAYDNSRKIEADYVQLDELLKNSDIVTLHVPLCADTRHLIGQSEIGEMKQGAFLINTGRGALVDTGSLVEALGSGKLGGAALDVLEGEDQFVYTDCSQKVLDHPFLSQLLRMPNVIITPHTAYYTERVLRDTTEKTIRNCLNFERSLQHE 116.10 gnl|BL_ORD_ID|4682|hsp_num:0 626 Z1_02350 Lysine racemase Loose 175 149.1 vanT gene in vanG cluster 27.42 3002972 protein homolog model n/a n/a glycopeptide antibiotic antibiotic target alteration glycopeptide resistance gene cluster; vanT MSLAIRYLALLPLFVITACQQPVNYNPPATQVAQVQPAIVNNSWIEISRSALDFNVKKVQSLLGKQSSLCAVLKGDAYGHDLSLVAPIMIENNVQCIGVTNNQELKEVRDLGFKGRLMRVRNATEQEMAQATNYNVEELIGDLDMAKRLDAIAKQQNKVIPIHLALNSGGMSRNGLEVDNKSGLEKAKQISQLANLKVVGIMSHYPEEDANKVREDLARFKQQSQQVLEVMGLERNNVTLHMANTFATITVPESWLDMVRVGGIFYGDTIASTDYKRVMTFKSNIASINYYPKGNTVGYDRTYTLKRDSVLANIPVGYADGYRRVFSNAGHALIAGQRVPVLGKTSMNTVMVDITSLNNIKPGDEVVFFGKQGNSEITAEEIEDISGALFTEMSILWGATNQRVLVD MTKNESYSGIDYFRFIAALLIVAIHTSPLSSFSETGNFIFTRIVARVAVPFFFMTSGFFLISRYTCNAEKLGAFIKKTTLIYGVAILLYIPINVYNGYFKMDNLLPNIIKDIVFDGTLYHLWYLPASIIGAAIAWYLVKKVHYRKAFLIASILYIIGLFGDSYYGIVKSVSCLNVFYNLIFQLTDYTRNGIFFAPIFFVLGGYISDSQNRLSLKRSIVGFIVCFALMFGEALTLHHFDIQKHDSMYVLLLPSVYCLFNLLLHFRGKRRTGLRTISLIIYIIHPFMIVVIRLFAKLLHLQSLLVENSLVHYIAVCFASVVLAVVITALLSSLKPKKAKHTADTDRAYLEINLNNLEHNVNTLQKAMSPKCELMAVVKAEAYGHGMYEVTTYLEQIGVSSFAVATIDEGIRLRKYGISSEILILGYTSPSRAKELCKYELTQTLIDYRYSLLLNKQGYDIKAHIKIDTGMHRLGFSTEDKDKILAAFSLKHIKVAGIFTHLCAADSLEENDVAFTNKQIGSFYKVLDWLKSSGLNIPKVHIQSSYGLLNYPELECDYIRVGVALYGVLSSTNDKTKLELDLRPVLSLKAKVVLIRKIKQGESVGYSRAFTATRDSLIAILPIGYADGFPRNLSCGNSYVLIGGRQAPIVGKICMDQLAVDVTDIPNVKTGSIATLIGKDGKEEITAPMVAESAESITNELLSRMGHRLNIIRRA 57.16 gnl|BL_ORD_ID|1525|hsp_num:0 1561 Z1_02360 HTH-type transcriptional regulator HdfR Loose 550 42.4 NmcR 38.46 3003665 protein homolog model n/a n/a carbapenem; cephalosporin; cephamycin; penam antibiotic inactivation NmcA beta-lactamase MINANRPIMNLDLDLLRTFVAVADLNTFAAAAAAVCRTQSAVSQQMQRLEQLVGRELFARHGRNKLLTEHGLQLLGYARQILRANDDATASLTYSDAEGELRIGASDDSVDTLLPFLLNRIASVYPRLAVDVRIKRSQFIETMLDNHEIDLALTTARIGHHPRTALRTAPVLWHCAPDFQLQMNEPIPLVVMDETNPFRQLATNTLDDAGIQWRIAYEAASLSAVRAAVNAEVGITARPLEMQNADLRILGESEGLPRLPETQYWLYRNFDEQNEAVLTVFNAIENKKTPYTVTSVEEAHSLDLE MRARLPLNALRAFEASARYLNFTKAGLELHVSQAAVSQQVRTLEQMLGVALFTRVPRGLQLTDEGMHLLPSITEALQMMSSAMDKFHEGKIKEVLTIAVVGTFAIGWLLPRITAFLNENPWIDIRILTHNNVVNLAAEGIDASIRFGTGGWINTENILLFQAPHTVLCSPETSKKLYIPSDLKKVCLLRSYRKEEWNNWFKAAGIDPWTITGPIFDSTRLMIDAVKLGDYAALVPYHMFQKELNERSVAKPFEIYATLGGYWLTLQKSRVNHNSEALNVFKEWIIEHSREFVLKS 103.39 gnl|BL_ORD_ID|1908|hsp_num:0 2072 Z1_02373 NADH-quinone oxidoreductase subunit N Loose 750 40.4 blt 31.25 3003006 protein homolog model n/a n/a fluoroquinolone antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MTITPEQLIAMLPLLVVILTVVVVMLSIAWRRDHFTIATLTATGFIIALGSLYYVNALGVVDVTTLYHVDGYSSFFTALTIIAGLGTVAFAYPWLEGYQDNKEEFYMLVAIAVIGGILLSSAHHLASMFIGIELLTLPLFGLIGYAFQQRPSLEASIKYMLLSAAASSFLLFGMALLYAEAGNLSFTAMGQSLSDSNIHKPLVLAGLGMMLVGIGFKLSLFPFQLWTPDVYQGAPAPTGAFLATASKIGIFAVVMRLFLEAPAADSETLRMILGFMAIASILFGNIMALTQKNVKRLLGYSSVSHLGYLLVALIVLQYSPILAQETAEIYLAGYLFASLGAFGAIAVASSPYNKGELESLEDYRGLFWRRPVAAIVMSLMMLSLAGVPITLGFIGKLYVILAGIDSSLWWLTGMVVLGSAIGLFYYLRAAAIVFLRKPDNDNAPAVTTTSQNMATLITLVCAIIVIVLGVWPQPLIELTRFAIIAPAIN MKKSINEQKTIFIILLSNIFVAFLGIGLIIPVMPSFMKIMHLSGSTMGYLVAAFAISQLITSPFAGRWVDRFGRKKMIILGLLIFSLSELIFGLGTHVSIFYFSRILGGVSAAFIMPAVTAYVADITTLKERSKAMGYVSAAISTGFIIGPGAGGFIAGFGIRMPFFFASAIALIAAVTSVFILKESLSIEERHQLSSHTKESNFIKDLKRSIHPVYFIAFIIVFVMAFGLSAYETVFSLFSDHKFGFTPKDIAAIITISSIVAVVIQVLLFGKLVNKLGEKRMIQLCLITGAILAFVSTVMSGFLTVLLVTCFIFLAFDLLRPALTAHLSNMAGNQQGFVAGMNSTYTSLGNIFGPALGGILFDLNIHYPFLFAGFVMIVGLGLTMVWKEKKNDAAALN 122.25 gnl|BL_ORD_ID|1828|hsp_num:0 1975 Z1_02392 Sensor histidine kinase RcsC Loose 2300 134.8 evgS 33.21 3000833 protein homolog model n/a n/a macrolide antibiotic; fluoroquinolone antibiotic; penam; tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump MLWAMGALLTMFYLINIFNDTKSDIRQEYSNNYTDLLGFFRQTSSTIRDLQYLAERHQEQLNLNPKMNNSFFYEGPFSLHKLSESADCELFKGQTNNYFRSFNSILYYWKDNTPALQGINQVFMVGSHSMCMINFPLRASPIDTELLKKMVYENTRNYINQRAQGKESNQYWIVPDAKGDSGILYVMSPVYASGKFIALIGIERAIRLEYFSPTKDRVISIHLLNNKNNPVLSYPEENNYRSVRDVPDVSAPYFGFDDDFSDLVAKRKLLPSSFSVVYSLPLKQILNEFKFTIFNAIILNIISAIVIFIFVWIFERKIFSPAENNASRLEEHEQFNHKIVASAPVGISILRIRDGMIILSNELAHNYFRLLSHSDKQNILSIIAEKSSNIVDVVTNNHNHLQISFVNSRYQNEDVAICVLVDISARVKMERSLQNMATAAEQANQAKSMFLATVSHELRTPLYGIIGNLELLQSLTQNEETARLLKTMDNSSSLLLKIISDILDFSKIESKQLKIDVKPFNCRQVVSFVISNYLPLIAKKDLAIYCFIEPDVPKIVNNDPVRVQQVISNLLNNSIKFTTTGCITLHLYRDEYYLYFDIHDTGRGINEKMLHQLFEPFFQVSQNTESASEGTGLGLAICEKLINLMDGDISVVSQENVGSRFTVRIPLYGALNSSDGQTKYNLYKESTIRCFISIKNLYLESFVERYLSYVGLHCQLFTEVTQVSENDFIITDHDECLDNSCQFIRIYEHYFEPAKKISENNWLCSTYKLNELIKIILQLPQTKLESDDSENNALMTDHDLQLLTVLIVDDHPINRLLLTDQLKKIGFNTATAEDGCDALAFMQENHVDIILTDVNMPNMNGYQLATTVRELSSTIPIIGVTANAIAEEKQRCIDAGMNDCVSKPVSLTVLKDVLLTYVA MKFLPYIFLLCCGLWSTISFADEDYIEYRGISSNNRVTLDPLRLSNKELRWLASKKNLVIAVHKSQTATLLHTDSQQRVRGINADYLNLLKRALNIKLTLREYADHQKAMDALAEGEVDIVLSHLVTSPPLNNDIAATKPLIITFPALVTTLHDSMRPLTSPKPVNIARVANYPPDEVIHQSFPKATIISFTNLYQALASVSAGHNDYFIGSNIITSSMISRYFTHSLNVVKYYNSPRQYNFFLTRKESVILNEVLNRFVDALTNEVRYEVSQNWLDTGNLAFLNKPLELTEHEKQWIKQHPNLKVLENPYSPPYSMTDENGSVRGVMGDILNIITLQTGLNFSPITVSHNIHAGTQLSPGGWDIIPGAIYSEDRENNVLFAEAFITTPYVFVMQKAPDSEQTLKKGMKVAIPYYYELHSQLKEMYPEVEWIQVDNASAAFHKVKEGELDALVATQLNSRYMIDHYYPNELYHFLIPGVPNASLSFAFPRGEPELKDIINKALNAIPPSEVLRLTEKWIKMPNVTIDTWDLYSEQFYIVTTLSVLLVGSSLLWGFYLLRSVRRRKVIQGDLENQISFRKALSDSLPNPTYVVNWQGNVISHNSAFEHYFTADYYKNAMLPLENSDSPFKDVFSNAHEVTAETKENRTIYTQVFEIDNGIEKRCINHWHTLCNLPASDNAVYICGWQDITETRDLINALEVEKNKAIKATVAKSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALSCSSTFPEHYLVKIDPQAFKQVLSNLLSNALKFTTEGAVKITTSLGHIDDNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPVEISQQVATVEAKAEQPITLPEKLSILIADDHPTNRLLLKRQLNLLGYDVDEATDGVQALHKVSMQHYDLLITDVNMPNMDGFELTRKLREQNSSLPIWGLTANAQANEREKGLSCGMNLCLFKPLTLDVLKTHLSQLHQVAHIAPQYRHLDIEALKNNTANDLQLMQEILMTFQHETHKDLPAAFQALEAGDNRTFHQCIHRIHGAANILNLQKLINISHQLEITPVSDDSKPEILQLLNSVKEHIAELDQEIAVFCQKND 76.78 gnl|BL_ORD_ID|1217|hsp_num:0 1318 Z1_02394 Phosphotransferase RcsD Loose 700 50.8 adeS 20.9 3000549 protein homolog model n/a n/a glycylcycline; tetracycline antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MRTLTQLKPNTLTRLYALFLLFMAISLFLYAYSYFDTWLESKKNAINNTTNKFASQVEDYRYHANQLFQLSNKINDPTLFLPLKINPVKLRSDVYWLEGRDQTVDAIVFGKSNEQTFQLAGYFANALEIIWGVRNNYSSLYYLNGKGNDLILITTHSILKPELRYKESYLTLTAENKRSELLMQSTALDEKESLSPIRKMPTENIYYYTYRTMFNVPGQLTSVIAFDLPINNFLPAELSPQYLRLLPTGQQSVYDKNNIEVSTDGTSLIFSQPIAGIPYSLSYEYPLKSIFNEIVYKNIWLLISLLIFISISVFGHIYIRNKYVFPYISMTRNLRIKEEMTNDIISNLPIGLLVYNFSSNHKIISNSHAEKLLPHIDLSKIRQMAIEHNGLIQTAIDNEIYEIRTSSNSNIDNTALFIFLNKDNEALINKKLQLAQQEYEKNTIARRKILSNMSLELIRPIKDINEMVYQFKDLLPNDTHQQLLSLLLEKTNYISEWIENITLINKLENQEWKIHQDEFELSTLVESILITASPFMIRKGLTLYFHNNIKPSLLLFNDGPALSKIILSLINYAISTTNYGKITVNLNLEKNNDKEEIVIDIIDSGSGLTAQDLANIKYPFLGQAMGDKYYSNSGIIFYLCHLLCNKIQGTLTITSQESIGSHFRIVLPYQHIDTEERSFDILLEGITAKLAIKNPEIEKIICQQLDKYGATYFDKNKENLYSEYDIILRDTPDNNPESATVLLVSSITGFEKIARNLIKCNYNFGDPLIEAITYLIEENEQLSLETTQTSIRNENNNLDHHEVILNNYRKKLNDSDYKELFINTVPIDVEKLHLEATNKDFHSLAQTAHRLKGVFAMLDLEYLRENCEYLEDDIKNHNELEIKERINQLDKWIRQLL MKSKLGISKQLFIALTIVNLSVTLFSIVLGYIIYNYAIEKGWISLSSFQQEDWTSFHFVDWIWLATVIFCGCIISLVIGMRLAKRFIVPINFLVEAAKKISHGDLSARAYDNRIHSAEMSELLYNFNDMAQKLEVSVKNAQVWNAAIAHELRTPITILQGRLQGIIDGVFKPDEVLFKSLLNQVEGLSHLVEDLRTLSLVENQQLRLNYELFDLKAVVEKVLKAFEDRLDQAKLVPELDLTSTPVYCDRRRIEQVLIALIDNAIRYSNAGKLKISSEVVADNWILKIEDEGPGIATEFRDDLFKPFFRLEESRNKEFGGTGLGLAVVHAIIVALKGTIKYSNQGSKSVFTIKISMGHEEMG 248.48 gnl|BL_ORD_ID|167|hsp_num:0 183 Z1_02430 Swarming motility regulation sensor protein RssA Loose 900 147.1 basS 30.57 3003583 protein homolog model n/a n/a peptide antibiotic antibiotic target alteration; antibiotic efflux pmr phosphoethanolamine transferase MKIRSFFIYTIFLQTISIVMLWGVWLAWIEFDYLADFETIYNKQQEIIAEGFANTLETVSSQPETVKQIAHHLQNMYIDTMLNGEDDDLHYLPWFIVLNKDNDLIYTNRPELSLPKRVLSLASEKISVAGEKWYLSYSWGKQHKIKVFIGESVEDRGHVIGNPISGTFVPFLFILATVILAILITAYFSLRPLRQAAELISNRKPRNLTPINVGQQFKEIRPIFKELNQLMARIDAANIREKQFMADAAHELRTPIAAVIAQLHILSLVDEKQEREEIIEDMKQSLDRAAALSHQLIDLARLECDDFPIKIESFDVYNIIGNAIAQRVPYALTKNIELSLNEGMSLKIETDKQALLSIFNNLLDNAIKYCPNNSQVEVTIEHKDTHHLNIILRDNGPGIAPEYISSLFSRFYRVPGSQGTGSGLGLSIAQNLAEKIQATISITEGLHNKGIGFIITLPLKIKPLDNE MSRAAVPSVRRRLLVNLLVGFVLCWLSVAALTYHLSLKQVNRLFDDDMVDFGEAALRLLDLATEDQAGEDGSITEIIERSREAIQGLPLLRRESALGYALWRDGQPLLSSLNLPPEITAQGPGFSTVEAQGTHWRVLQLNIDGFQIWISENLIYRQHTMNLLLFYSLFPLLLALPLLGGLVWFGVARGLAPLREVQAEVQQRSARHLQPIAVEAVPLEIRGLIDELNLLLERLRTALEAERRLTSDAAHEIRTPLASLRTHAQVALRSEDPKAHARGLLQVSRSVERISTLMEQILLLARLDGDALLEQFHPVNLATLAEDVLSELARQAIDKDIELSLHQETVHVMGIDLWLKAMVGNLVGNALRYTPAGGQVEIRVENRAQHAVLRVRDNGPGVALEEQQAIFTRFYRSPATSSGEGSGLGLPIVKRIVELHFGSIGLGKGLEGKGLEVQVFLPKTQPDATRPPARGPDSGRSHI 97.90 gnl|BL_ORD_ID|2358|hsp_num:0 249 Z1_02431 Swarming motility regulation protein RssB Loose 420 124.4 mtrA 35.48 3000816 protein homolog model n/a n/a macrolide antibiotic; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MNILLVEDDLQLGKALCRGLEIAGFQPCWVRLLTDARVQLNQKAFDLMLLDLGLPDGDGQDELIALRKSGEKIPIIILTARTQIDNLVQTLDSGADDFLPKPFAMPELISRVKAVSRRMAGFSSQIWSIGDLQLNPSNHQVTLNGELLLLSGKEYQLLYELMRNTDNVVRKSDLEQRLFGLDDKIESNSLEVHMHNLRRKIGKERIITVRGIGYLLKKEVN MDTMRQRILVVDDDASLAEMLTIVLRGEGFDTAVIGDGTQALTAVRELRPDLVLLDLMLPGMNGIDVCRVLRADSGVPIVMLTAKTDTVDVVLGLESGADDYIMKPFKPKELVARVRARLRRNDDEPAEMLSIADVEIDVPAHKVTRNGEQISLTPLEFDLLVALARKPRQVFTRDVLLEQVWGYRHPADTRLVNVHVQRLRAKVEKDPENPTVVLTVRGVGYKAGPP 96.93 gnl|BL_ORD_ID|1434|hsp_num:0 1559 Z1_02434 Chloramphenicol acetyltransferase Loose 400 160.2 catB9 45.92 3002681 protein homolog model n/a n/a phenicol antibiotic antibiotic inactivation chloramphenicol acetyltransferase (CAT) MNTKHWSRVEYLHETVKNKNIIIKGQHSYYSDCWDNGFEASVVRYLYGDEFSLQWEPLWEIDKLYIGDYVCIGAEAVILMGGNHTHRMDWFSLYPFLDNIKEAYIGKGDTYIHDGVWIGMRAMIMPGVTIGEGAIIAANSVVTKDVAPYSIVGGIPAKHVKYRFEPKVIEQLLSLNIYSWPEKKFAALKPYLCQASIDKLLTAHTQYNQDMK MNFFTSPFSGIPLDQQVTNPNIIVGKHSYYSGYYHGHSFDDCVRYLHPERDDVDKLVIGSFCSIGSGAVFMMAGNQGHRSDWISTFPFFYQDNDNFADARDGFTRSGDTIIGHDVWIGTEAMIMPGVKIGHGAIIASRSVVTKDVAPYEVVGSNPAKHIKFRFSDVEIAMLLEMAWWNWPESWLKESMQSLCSSDIEGLYLNWQSKART 101.44 gnl|BL_ORD_ID|92|hsp_num:0 106 Z1_02440 Staphyloferrin B transporter Loose 700 557.8 mdtG 72.24 3001329 protein homolog model n/a n/a phosphonic acid antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MNLKPRNNSWKRNLYIVWFGCFLTGAGFSLIMPFLPLYVEELGIKDHESLNLWTGVAFSITFLFSAIAAPFWGKLSDRKGRKLMLLRSALGMAIVMVLIGFAQNIWQLLILRALLGVLGGFVPNANALIATQVPVKKSGWALGTLSTGAVSGALIGPLIGGILADLYGLRPVFFITAAVLFICFIVTLFFVSENFTPVSKKDALSTQQVFSSLKNKRLVICLFFTTMIIQVATGSVTPILTLYIRDLAGSISNLAFISGVIASVPGIAALISAPRFGKLGDRIGPDKVLIFTLGLSIFMLIPMALVSNYWELGALRFLLGAVNAAMLPAVQTLILYNITPAIAGRIFSYNQALRDVGNVTGPLMGAFVAANYGFRAVFYFTAAVVFFNLIYSWISFRTPQRK MSPCENDTPINWKRNLIVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSALNMWSGIVFSITFLFSAIASPFWGGLADRKGRKLMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPMAGGLLADSYGLRPVFFITASVLILCFFVTLFCIREKFQPVSKKEMLHMREVVTSLKNPKLVLSLFVTTLIIQVATGSIAPILTLYVRELAGNVSNVAFISGMIASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSYVQTPLQLGILRFLLGAADGALLPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISANYGFRAVFLVTAGVVLFNAVYSWNSLRRRRIPQVSN 98.53 gnl|BL_ORD_ID|551|hsp_num:0 603 Z1_02442 Tetrathionate response regulatory protein TtrR Loose 300 50.8 Escherichia coli uhpA with mutation conferring resistance to fosfomycin 35.51 3003893 protein variant model G97D phosphonic acid antibiotic antibiotic target alteration antibiotic-resistant UhpT MVPMAVEEIKKGAIDFLQKPVDSNALLSALKSAFTETATRFTADDIRRRYASLTPREKDIAYYVIQGLMNREIAETACVSIRTVEVHRAKVMDKMAVKNIAELVTALQGIDIVAPNL MITVALIDDHLIVRSGFAQLLGLEPDLQVVAEFGSGREALAGLPGRGVQVCICDISMPDISGLELLSQLPKGMATIMLSVHDSPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGCYLTPDIAIKLASGRQDPLTKRERQVAEKLAQGMAVKEIAAELGLSPKTVHVHRANLMEKLGVSNDVELARRMFDGW 59.69 gnl|BL_ORD_ID|2145|hsp_num:0 2374 Z1_02443 Tetrathionate response regulatory protein TtrR Loose 400 47.4 vanR gene in vanF cluster 32.53 3002925 protein homolog model n/a n/a glycopeptide antibiotic antibiotic target alteration glycopeptide resistance gene cluster; vanR MPTIHLVDDDLAVTDACQFLLESLGYAAQVWNDSEYFLHNIDLYQQGVVLLDMRMPKADGRQVHQYLIEKHSTLAVIFLTGHGADGG MKNITILIADDDAEIADLVAIHLEKEGYRVIKVSDGQETIDVIQNQPIDLLILDIMMPKMDGFEVTRRIREKHNMPIIFLSAKTSDFDKVQGLVIGADDYMTKPFIPIELVARVNAQLRRFMKLNQPKTKQNSNLEFGGLTISPEQRTVTLYGKNIELTPKEFEILFLLASNPNKVYRAEDIFQKVWGDAYYEGGNTVMVHIRTLRKKLEEDKRKNKLIQTVWGVGYKFNG 37.66 gnl|BL_ORD_ID|299|hsp_num:0 240 Z1_02444 Tetrathionate sensor histidine kinase TtrS Loose 700 50.8 vanS gene in vanE cluster 22.27 3002935 protein homolog model n/a n/a glycopeptide antibiotic antibiotic target alteration vanS; glycopeptide resistance gene cluster MTIKQTIGIKKIASLSLLLLFFLLSSSAVAKEWTIGVLALRGDASTQRHWQPLIDTLDQQIPTDSFLLLPLNLSEMKQAVADKRVDFLLTNPAQFVQLDSAYPLRWLLSLRSGYEPDNTTRNVIGSLILVRKDSAITSIHELVGKRVGAIAPDAFGGYLLGYKALREEGIDPEQDFTLRFSGFPADALLYLLRDGDINAAIIPVCLLENMDNEGLINKEDYRPLLNYSTNTSCLTSTPLYPNWSFAALDTVPDTLVDKVTRTLLNDESDAMKWGAPASHSQVENLLREVNQHPRQRQLWQDAKIWAIQHRFIIGLSLGAIILLVFNQIWISYLVRRRSHQLEQAHIHLREQKEALEQAQRLNILGEMASGFAHELNQPLSAIKSYAQGSAIRLEKENKNHPLLPALRQIDQQAQRGADIIRNLRLWVGKQSANSDTVPLSEQNIAQCIEHIWRLLRIDEKYPQVTLITKIDKHDTLYLPETLLEQILSNLITNSLQAGTKVLQISTHKAPDRLLIVIKDDAGGMSHSQLEQPFSPFQTTKTEGLGLGLVICQRLLNSQGADIHIENQKDKQNNVGLKITLIFPNNNN MKNNLTVQITKKYFYTMIIITTILVILPLVAKMFLSLRVWQGTEFFYPILYILNRSLGVWLIVTPLFIWLIVTYMFFRKMISYLEEMIVATKSLIETPNEKIVLRVELAEFENEINHIRIDSLENKKMAEEAGKKRDDLLTYLAHDLRTPLTSIIGYISLLQNEQTYLELDSTKRKNYIDIISDKANRLEHLLNDFFEIAKTGKSREEVYKEEVDLSLMLSQISSEFLPLLDEKKLEWDFKIEPNVFVQLNINKFERVLDNLIRNAISYSLNDTTIKLTLEKVDEKVVVSVGNITDKVSEKDIDQLFEPFYRGDKSRNTKTGNAGLGLAIAKQIISEHGGTIEAELQNNDFKVSIIL 164.43 gnl|BL_ORD_ID|1507|hsp_num:0 1571 Z1_02469 Protein-glutamate methylesterase/protein-glutamine glutaminase Loose 400 48.5 vanR gene in vanF cluster 26.67 3002925 protein homolog model n/a n/a glycopeptide antibiotic antibiotic target alteration glycopeptide resistance gene cluster; vanR MNKITVLCVDDSALMRQIMREIINSHHDMEVVDCAPDPIVARDLIKKFNPQVLTLDVEMPRMDGIDFLEKLMRLRPMPVVMVSSLTAKGSEVTLKALELGAVDFVTKPQLGLREGMLAYSELIAEKIRAAAQARISRHETKTLPSKSLSFTPMISSEKLIAVGASTGGTEAIRHFLEPLPITSPAVLITQHMPAGFTHSFAERLNRLCQISVKEAEDGERVLPGHAYIAPGDYHMELRRNGANYQIHINKDPAVNRHRPSVDVLFNSVAKYAGRNAIGVILTGMGSDGATGLLAMRRAGSYTFAQDEASCVVFGMPRSAVELGAVDEVKSISSMSKAVLMKISTTQSLRI MKNITILIADDDAEIADLVAIHLEKEGYRVIKVSDGQETIDVIQNQPIDLLILDIMMPKMDGFEVTRRIREKHNMPIIFLSAKTSDFDKVQGLVIGADDYMTKPFIPIELVARVNAQLRRFMKLNQPKTKQNSNLEFGGLTISPEQRTVTLYGKNIELTPKEFEILFLLASNPNKVYRAEDIFQKVWGDAYYEGGNTVMVHIRTLRKKLEEDKRKNKLIQTVWGVGYKFNG 151.52 gnl|BL_ORD_ID|299|hsp_num:0 240 Z1_02470 Chemotaxis protein CheY Loose 2300 74.3 evgS 35.83 3000833 protein homolog model n/a n/a macrolide antibiotic; fluoroquinolone antibiotic; penam; tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump MASKDLRFLVVDDFSTMRRIVRNLLKELGFMNVEEAEDGADALAKLQSSAYDFVITDWNMPNMDGLELLKNIRSDAGLATLPVLMVTAEAKKENIIAAAQSGASGYVVKPFTAAILEEKLNKIFEKLGI MKFLPYIFLLCCGLWSTISFADEDYIEYRGISSNNRVTLDPLRLSNKELRWLASKKNLVIAVHKSQTATLLHTDSQQRVRGINADYLNLLKRALNIKLTLREYADHQKAMDALAEGEVDIVLSHLVTSPPLNNDIAATKPLIITFPALVTTLHDSMRPLTSPKPVNIARVANYPPDEVIHQSFPKATIISFTNLYQALASVSAGHNDYFIGSNIITSSMISRYFTHSLNVVKYYNSPRQYNFFLTRKESVILNEVLNRFVDALTNEVRYEVSQNWLDTGNLAFLNKPLELTEHEKQWIKQHPNLKVLENPYSPPYSMTDENGSVRGVMGDILNIITLQTGLNFSPITVSHNIHAGTQLSPGGWDIIPGAIYSEDRENNVLFAEAFITTPYVFVMQKAPDSEQTLKKGMKVAIPYYYELHSQLKEMYPEVEWIQVDNASAAFHKVKEGELDALVATQLNSRYMIDHYYPNELYHFLIPGVPNASLSFAFPRGEPELKDIINKALNAIPPSEVLRLTEKWIKMPNVTIDTWDLYSEQFYIVTTLSVLLVGSSLLWGFYLLRSVRRRKVIQGDLENQISFRKALSDSLPNPTYVVNWQGNVISHNSAFEHYFTADYYKNAMLPLENSDSPFKDVFSNAHEVTAETKENRTIYTQVFEIDNGIEKRCINHWHTLCNLPASDNAVYICGWQDITETRDLINALEVEKNKAIKATVAKSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALSCSSTFPEHYLVKIDPQAFKQVLSNLLSNALKFTTEGAVKITTSLGHIDDNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPVEISQQVATVEAKAEQPITLPEKLSILIADDHPTNRLLLKRQLNLLGYDVDEATDGVQALHKVSMQHYDLLITDVNMPNMDGFELTRKLREQNSSLPIWGLTANAQANEREKGLSCGMNLCLFKPLTLDVLKTHLSQLHQVAHIAPQYRHLDIEALKNNTANDLQLMQEILMTFQHETHKDLPAAFQALEAGDNRTFHQCIHRIHGAANILNLQKLINISHQLEITPVSDDSKPEILQLLNSVKEHIAELDQEIAVFCQKND 10.78 gnl|BL_ORD_ID|1217|hsp_num:0 1318 Z1_02527 23S rRNA (guanine(745)-N(1))-methyltransferase Loose 550 130.6 RlmA(II) 29.26 3001301 protein homolog model n/a n/a macrolide antibiotic; lincosamide antibiotic antibiotic target alteration non-erm 23S ribosomal RNA methyltransferase (G748) MSYQCPLCSQPLALKAHSWVCDNHHQFDCAKEGYVNLLPVQFKRSKEPGDSAEMISARRDFLDAGFYQPMRDKVAQLVAEHLPEDNPQVLDIGCGEGYYTYQIYQQLKSKNPQVYGLDVAKVAIKYAAKRYAPIQFCVASSQRLPFCDASLNAVVRIYAPCNASELTRVIAQGGYIITVTPAPRHLYQLKALIYSTVHLHPLKDEIFAGFKLIAQHQVAYNMALTGKQAVDLLQMTPFAWRASEEVKEKLDKTEQFACETDFLIRVYQRV MNTNLKPKLQRFASATAFACPICQENLTLLETNFKCCNRHSFDLAKFGYVNLAPQIKQSANYNKENFQNRQQILEAGFYQAILDAVSDLLASSKTTTTILDIGCGEGFYSRKLQESHSEKTFYAFDISKDSVQIAAKSEPNWAVNWFVGDLARLPIKDANMDILLDIFSPANYGEFRRVLSKDGILIKVIPTENHLKEIRQRVQDQLTNKEYSNQDIKEHFQEHFTILSSQTASLTKTITAEQLQALLSMTPLLFHVDQSKIDWSQLTEITIEAEILVGKAF 95.74 gnl|BL_ORD_ID|2057|hsp_num:0 2274 Z1_02539 Regulatory protein SoxS Loose 215 103.2 Salmonella serovars soxS with mutation conferring antibiotic resistance 45.63 3003383 protein variant model E52K fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics antibiotic target alteration; antibiotic efflux; reduced permeability to antibiotic ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams MPQDNHLALVCALSKWIEEHLGRVIHLEELAAYSGYSLWHMQKIFKEVTGTSLGKYIRQRRLAGAIHLLRTSDRSIFDIALDFGFGSQSHFTYMFRKEYGITPFDFRQNQDIELETKQPLHLQSLCCD MSHQQIIQTLIEWIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGEYIRQRRLLLAAVELRTTERPIFDIAMDLGYVSQQTFSRVFRREFDRTPSDYRHRL 119.63 gnl|BL_ORD_ID|1983|hsp_num:0 1671 Z1_02547 Transcriptional regulatory protein BaeR Loose 450 304.3 baeR 65.22 3000828 protein homolog model n/a n/a aminoglycoside antibiotic; aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MTTTTSTYSILIVEDEPKLAQLLIDYLQASDYQTQWLADGTEVIQHIKQSHYDLVLLDLMLPGKDGITLCKELRQFSDIPIIMVTAKTEEVDRLLGLEIGADDYICKPYSPREVVARVKTLLRRYYRPQDIVQNSALVIIDEQAYQIQYHNKILDLTTAEFRLIKALATQPGKVLSRDQLMDHLYDDYRIVTDRTIDSHIKNLRRKLEQLNDQIEFIRSIYGQGYRWETAAYRFR MTELPIDENTPRILIVEDEPKLGQLLIDYLRAASYAPTLISHGDQVLPYVRQTPPDLILLDLMLPGTDGLTLCREIRRFSDIPIVMVTAKIEEIDRLLGLEIGADDYICKPYSPREVVARVKTILRRCKPQRELQQQDAESPLIIDEGRFQASWRGKMLDLTPAEFRLLKTLSHEPGKVFSREQLLNHLYDDYRVVTDRTIDSHIKNLRRKLESLDAEQSFIRAVYGVGYRWEADACRIV 97.92 gnl|BL_ORD_ID|1234|hsp_num:0 1337 Z1_02548 Signal transduction histidine-protein kinase BaeS Loose 850 479.2 baeS 53.96 3000829 protein homolog model n/a n/a aminoglycoside antibiotic; aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MKLRSKLFLVIFATCMIVVFAMHIGIRSSFQQGFIGYIKKNSEQRATLLAEALSDQYQLTGDWRFLNRDDRSIYQILRTIDQISQSGEGPAPRGWRTQFWIVDKQMKRLFGHDNQFPAETFKKPITYHDEIVGWVIVSAADKISNEADISFDKQQLRTSWIIAGLTVLFALLITLILSRSMIRPVKRLVEATHKLAAGDFAVRVTPTNKDEISQLATDFNQLASTLEKNEQIRRDYMADISHELRTPLAILKGELEALQDGVRKPTAETLNSLLFEVTNLTKLVNDLHQLSLSDRGSLTYRKDFIDINEIILLAVASYRHIYQAKEIALQTDLDDNVKLIVQADPDRLIQLFHNLLENSVRYTNSGGQLHISSKREHNNVLIVWEDSAPGLDKAQYEAVFQRFYRAESSRNRSSGGSGLGLAICENIVEAHNGKITAMPSAIGGVKILIVLPVYSEDN MKFWRPGITGKLFLAIFATCIVLLISMHWAVRISFERGFIDYIKHGNEQRLQLLSDALGEQYAQHGNWRFLRNNDRFVFQILRSFEHDNSEDKPGPGMPPHGWRTQFWVVDQNNKVLVGPRAPIPPDGTRRPILVNGAEVGAVIASPVERLTRNTDINFDKQQRQTSWLIVALATLLAALATFLLARGLLAPVKRLVDGTHKLAAGDFTTRVTPTSEDELGKLAQDFNQLASTLEKNQQMRRDFMADISHELRTPLAVLRGELEAIQDGVRKFTPETVASLQAEVGTLTKLVDDLHQLSMSDEGALAYQKAPVDLIPLLEVAGGAFRERFASRGLKLQFSLPDSITVFGDRDRLMQLFNNLLENSLRYTDSGGSLQISAGQRDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERDLQREV 98.07 gnl|BL_ORD_ID|916|hsp_num:0 986 Z1_02549 Multidrug resistance protein MdtC Loose 1800 1412.1 mdtC 72.79 3000794 protein homolog model n/a n/a aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MKLFALFIQRPVATTLLSLAISLCGALGFMLLPVAPLPQVDYPVINIYASLPGASPETMASSVATPLERSLGRIAGIDEMTSSSALGSTSITLVFDLNKDINTAARDVQAALNASQSLLPSGMPSRPRYYKSNPSDAPIMILTLTSETQNTGELYDLASTRLAQKISQIEGVSEVSVGGGSLPAVRVALNPDALFNQNVSLDDVRKAISQSNVRRPQGFIHNDENRWQIQTNDELSKAQDYRPIIVHYNQDAIVRLSDVAQVTDSVQNARAAGMSGGEPAILLVIRREAGANIIETVNRIRDELPELRELLPASVNLKVAQDRTPTIRASLAEVERALAIAVALVILVVFLFLRSGRATLIPAVAVPVSLIGTFSAMYLCGFSLNNLSLMALTVATGFVVDDAIVVLENISRHIENGLKPKQAALKGVSEVGFTVLSMSISLVAVFIPLLLMDGLVGRLFKEFAITLTTAIGISLFVSLTLTPMMCAHLLKGIKPKAQSHLRGFGKLIFRLQQGYSVTLQAALRHKRWIMAIFITTLGLNAYLYISAPKTFFPDQDTGRLMGFVRADQSISFQSMKEKMTRFMQEINADKDVDSVTGFTGGGRINSGFMFISLNPLSERTDSANQVINRLRIKLANEPGATLFLMPVQDVRAGGRQANASYQFTLLADDLSELRKWEPLIRKALGELPELVDVNSDKEDKGAEMALTYDRDTMSQLGINVSDANNLLNNAFGQRQISTIYAPLNQYKVVMEVSEQYTQDVSALDKMYVMNTQGERIPLSAFASWYPANAPLSVNHQGLSAASTIAFNVPEGYTLSDAINAIERTMTELGVPNTVRGTFAGTAQIFQETIKSQLILILAAIVTVYIVLGVLYESYIHPLTILSTLPSAGVGALLALRLFDTPFSLIALIGIMLLIGIVKKNAIIMVDFAITAQREGKLSAQEAIIQASLLRFRPIIMTTLAALFGALPLMLSSGDGAELRQPLGITIVGGLLMSQLLTLYTTPIIYLFFDGVRQRWQQRRHNKKEANA MKFFALFIYRPVATILLSVAITLCGILGFRMLPVAPLPQVDFPVIIVSASLPGASPETMASSVATPLERSLGRIAGVSEMTSSSSLGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMPSRPTYRKANPSDAPIMILTLTSDTYSQGELYDFASTQLAPTISQIDGVGDVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRTAVSNANVRKPQGALEDGTHRWQIQTNDELKTAAEYQPLIIHYNNGGAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRAKLPELQETIPAAIDLQIAQDRSPTIRASLEEVEQTLIISVALVILVVFLFLRSGRATIIPAVSVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIVVLENIARHLEAGMKPLQAALQGTREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLLVSLTLTPMMCGWMLKASKPREQKRLRGFGRMLVALQQGYGKSLKWVLNHTRLVGVVLLGTIALNIWLYISIPKTFFPEQDTGVLMGGIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTGGSRVNSGMMFITLKPRDERSETAQQIIDRLRVKLAKEPGANLFLMAVQDIRVGGRQSNASYQYTLLSDDLAALREWEPKIRKKLATLPELADVNSDQQDNGAEMNLVYDRDTMARLGIDVQAANSLLNNAFGQRQISTIYQPMNQYKVVMEVDPRYTQDISALEKMFVINNEGKAIPLSYFAKWQPANAPLSVNHQGLSAASTISFNLPTGKSLSDASAAIDRAMTQLGVPSTVRGSFAGTAQVFQETMNSQVILIIAAIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRHGNLTPQEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRLRFSRKPKQTVTE 100.20 gnl|BL_ORD_ID|1215|hsp_num:0 1315 Z1_02550 Multidrug resistance protein MdtB Loose 1800 1481.1 mdtB 75.86 3000793 protein homolog model n/a n/a aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MSEKIPATGGGPSRLFILRPVATTLFMVAILLAGIVGYRMLPVSALPEVDYPTIQVVTLYPGANPEVMTSAVTAPLERQFGQMSGLKQMSSQSSGGASVITLMFQLTLPLDVAEQEVQAAINAATNLLPTDLPYPPIYSKVNPADPPVLTLAVTSSVLPMTQLQDMVETRISQKISQVNGVGLVSLAGGQRPAVRVKLNAQAAASYGLDSETIRVAINNANVNSAKGSLDGPTRSVTLSANDQMKSLDDYRKLIVSYKNGAPIRLADIATIEQAPENNQLGAWANNQQAIIINVQRQPGVNVIETTDNIRNLLPDLVSNLPKSVNVEILTDRTTSIRASVKDVQFELGLAIALVVMVIYLFLRNGVATLIPSIAVPLSLVGTFAVMYFCGFSVNNLTLMALTIATGFVVDDAIVVIENISRYLERGDKPLTAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAITLAVAILISAVVSLTLTPMMCARLLKPESQIKHNRFEMACERFFEKMIAVYAVWLKRVLNHQWITLGVALSTLALTVLLYLFIPKGFFPLQDNGLLQGTIETSQSISYQAMVEKQQQVVEKLIDDPAVENIASFVGIDGSNATLNTGRLQITLKPLDQRDSRIDEIIPRLQARVASIAGITLYLQPTQDLTIDTQVSRTQYQFTLQATSLDELAYWVPKLSQALQESPELTDISSDWQADGMMAYINVDRDSASRLGISMSSIDNALYNAFGQRLISTIYTQANQYRVVLEQNMHNSEGLQALSAVHLTGKEGAMVPLLSIASVEQRLAPLSINHQEQFPATTFSFNVAKDASLEAAVNAVKQAEEQIAMPKDITTQFQGATLAFESALSSTLWLIIAAIVAMYIVLGVLYESFIHPITILSTLPTAGVGALLALMAAGNELDIIAIIGIILLIGIVKKNAIMMIDFALAAEREQGLSPYEAIYQACLLRFRPILMTTMAALLGALPLMLSTGVGAELRQPLGVCMVGGLIMSQILTLFTTPVIYLLFDKLSLYLNRHKRVEHDNGAVS MQVLPPSSTGGPSRLFIMRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSTAMPMTQVEDMVETRVAQKISQISGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPSRAVTLSANDQMQSAEEYRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKEQAIVMNVQRQPGANIISTADSIRQMLPQLTESLPKSVKVTVLSDRTTNIRASVDDTQFELMMAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAITLAVAILISAVVSLTLTPMMCARMLSQESLRKQNRFSRASEKMFDRIIAAYGRGLAKVLNHPWLTLSVALSTLLLSVLLWVFIPKGFFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVDGTNPSLNSARLQINLKPLDERDDRVQKVIARLQTAVDKVPGVDLFLQPTQDLTIDTQVSRTQYQFTLQATSLDALSTWVPQLMEKLQQLPQLSDVSSDWQDKGLVAYVNVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIAKIEQRFAPLSINHLDQFPVTTISFNVPDNYSLGDAVQAIMDTEKTLNLPVDITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIVLGILYESFIHPITILSTLPTAGVGALLALLIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPREAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLIVSQVLTLFTTPVIYLLFDRLALWTKSRFARHEEEA 100.29 gnl|BL_ORD_ID|758|hsp_num:0 820 Z1_02551 Multidrug resistance protein MdtA Loose 725 422.5 mdtA 57.11 3000792 protein homolog model n/a n/a aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MNNNKKTKKRFSLIITLLIVIAGAIAYWQYSSNNSAPPVSKDTPTANTPNRSTAGSRRPPMPPVQVAISTQEDVPQFLTALGTVKAVNSVTVTSRVEGQLMALHFTEGQQVNQGDLLAEIDPRPFEVQLAQAKGQLAKDQSTLANARLDLARYQKLAKTHLVSQQELDNQAALVKQSEASISIDKAAINNAQLQLTYSKITAPISGRVGLKQVDVGNYISGGSSTPIVVINQMDPVDVLFTLPEQDLSQVILARKNNPTLPVIALDRNNKIELAQGALFSVDNQIDATTGTIKLKARFPQQESTLFPNQFVNIRLYVTTLEKAVVIPNAALQMGNEGHFVWVVDEENKVSKLAVEVASQNADKVVIASGLSANQRVVTDGVDRLTQGAKVEIVTPLAPKAKTTDPVVAEKA MKGSYKSRWVIVIVVVIAAIAAFWFWQGRNDSRSAAPGATKQAQQSPAGGRRGMRSGPLAPVQAATAVEQAVPRYLTGLGTITAANTVTVRSRVDGQLIALHFQEGQQVKAGDLLAEIDPSQFKVALAQAQGQLAKDKATLANARRDLARYQQLAKTNLVSRQELDAQQALVSETEGTIKADEASVASAQLQLDWSRITAPVDGRVGLKQVDVGNQISSGDTTGIVVITQTHPIDLVFTLPESDIATVVQAQKAGKPLVVEAWDRTNSKKLSEGTLLSLDNQIDATTGTIKVKARFNNQDDALFPNQFVNARMLVDTEQNAVVIPTAALQMGNEGHFVWVLNSENKVSKHLVTPGIQDSQKVVIRAGISAGDRVVTDGIDRLTEGAKVEVVEAQSATTPEEKATSREYAKKGARS 99.04 gnl|BL_ORD_ID|354|hsp_num:0 387 Z1_02554 Proline/betaine transporter Loose 700 168.3 Acinetobacter baumannii AbaF 28.37 3004573 protein homolog model n/a n/a phosphonic acid antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MTSQSHSTQPLSQPTARPLNRNDYKTLGLSSLGGTLEFYDFVIFVFFTKTLSHLFFPGDNAFIAQMQTLGIFAAGYLARPLGGIIMAHYGDIIGRKRMFTLSIFLMAVPTLVIGLLPTYASIGVAAPLLLLLMRIMQGAAIGGEMPGAWVFIAEHTPKQRYGLGVGTLTSGITGGILLGSIVAIIVQRSYSAQEVNDFAWRIPFILGGIFGLISVYLRRFLQETPIFKEMAAKKALAQEMPVVSVIKNHKQACLITAALTWSLSTAIVVTILMTPSVIVEGIYKIDRTTSLEANCVATLTLTLGCIFWGWLGDKLGTRASMTLSWGGLIVTAFHFYGSLDANMSGIQLAFNYGLMGFFVGAIATTPIVSTRAFPPSIRFSGLSFAYNMAYAVFGGLTPMLTGAWLEKTAMAGAYYVAAVSALAIVIAFLPLAYKGWIAVNTSSREKEIALQVDKVAS MTTTLKKVVAASMVGSVAEWYEFFLYGTASALVFGELFFQQTGNAIDGILAAFALYAVGFLARPLGGLVFGHYGDKIGRKKLLQISLIIVGITTFLMGCIPTFHQIGYWAPTLLVILRLIQGFAFGGEWGGAVILVSEHSPDDRRGYWASWPQTGVPLGNLVATLVLLLLSKNLSPEQFLDWGWRCAFWFSAVVVLIGLWIRKNVDDAEVFKEAQAKQQLLEKQQLGIIEVLKYHKKSVIAGIGARFAENILYYMVVTFSISYLKLVVHKDTSQILLLMFGAHLIHFFIIPFMGHLSDIFGRKPIYLIGAVLTAFWGFVGFPLMDTGNDWLIMLAIVLGLFIESMTYSPYSALMTELFPTHIRYTALSFCYQVAPIMAGSLAPLIALTLLKEFNSSIPISLYLVAASLISIVSILLVKETKGRSLAFKD 106.53 gnl|BL_ORD_ID|2725|hsp_num:0 3277 Z1_02585 Transcriptional regulatory protein DegU Loose 390 90.9 evgA 26.84 3000832 protein homolog model n/a n/a macrolide antibiotic; fluoroquinolone antibiotic; penam; tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump MPSYSIMIVDDHPIMRYGLRLLLEQDKEFIVVSESGNAQEAITTAKQLNPDLIMMDLHLQGRSGIDIIRSLRRCGLTSYVLVLSISDSRNDVYAALDAGANGYLLKECELDMLLLSLRKAVVGRPVYSEKVWQYIQLRQNYSDPLSALTKRELDVLQEVAVGMKNKQIAENLFISEETVKVHIRNILKKLQVTSRLAASLILIKHQH MNAIIIDDHPLAIAAIRNLLIKNDIEILAELTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQVLETLRKRQYSGIIIIVSAKNDHFYGKHCADAGANGFVSKKEGMNNIIAAIEAAKNGYCYFPFSLNRFVGSLTSDQQKLDSLSKQEISVMRYILDGKDNNDIAEKMFISNKTVSTYKSRLMEKLECKSLMDLYTFAQRNKIG 101.47 gnl|BL_ORD_ID|939|hsp_num:0 1015 Z1_02614 Fe(3+) ions import ATP-binding protein FbpC Loose 1280 91.3 macB 34.3 3000535 protein homolog model n/a n/a macrolide antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MLTIHSLTTGILTEVSLHLEQGCCLGISGSSGSGKTTLLNAIAGYTGYTGDIVLANQNMNKLPVWQRPCRYLNQRLYLFPFLTVKQNLWLAQYAAKQKRSKEKEIALLEQMGIAHLATRYPSQISGGEQQRVALARALISQPKLLLMDEPFSSLDWETRYQLWELIISLKKQQITMIIVTHEPRELQALADKTLLLSNGKIVQESKN MSLIECKNINRYFGSGENRVHILKDISLSIEKGDFVAIIGQSGSGKSTLMNILGCLDTAGSGSYRIDGIETAKMQPDELAALRRERFGFIFQRYNLLSSLTARDNVALPAVYMGMGGKERSARADKLLQDLGLASKEGNKPGELSGGQQQRVSIARALMNGGEIIFADEPTGALDTASGKNVMEIIRRLHEAGHTVIMVTHDPGIAANANRVIEIRDGEIISDTSKNPEIPASNVGRIQEKASWSFYYDQFVEAFRMSVQAVLAHKMRSLLTMLGIIIGIASVVSVVALGNGSQKKILEDISSMGTNTISIFPGRGFGDRRSGKIKTLTIDDAKIIAKQSYVASATPMTSSGGTLTYRNTDLTASLYGVGEQYFDVRGLKLETGRLFDENDVKEDAQVVVIDQNVKDKLFADSDPLGKTILFRKRPLTVIGVMKKDENAFGNSDVLMLWSPYTTVMHQITGESHTNSITVKIKDNANTRVAEKGLAELLKARHGTEDFFMNNSDSIRQMVESTTGTMKLLISSIALISLVVGGIGVMNIMLVSVTERTKEIGIRMAIGARRGNILQQFLIEAVLICIIGGLVGVGLSAAVSLVFNHFVTDFPMDISAASVIGAVACSTGIGIAFGFMPANKAAKLNPIDALAQD 32.14 gnl|BL_ORD_ID|447|hsp_num:0 487 Z1_02629 Response regulator UvrY Loose 390 52.0 evgA 23.65 3000832 protein homolog model n/a n/a macrolide antibiotic; fluoroquinolone antibiotic; penam; tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump MINTLVISQVEIFSLGIEKLLCQIKKINIRKIMNDESEAFRYCRQYSVNLIIFYSLPTVSLIDVIKRIKRFSPIIKIVVISPKIDSILSVTLLQLGIEGFIVIDSSAANVLQAIRQICIGQRYISPEIAMDIALTKVQADLNPLHHLSERELQIMSMIIRGKKIAQIAQELNISTKTVNSYRYRMFSKLKISGDVELTHIAVRYGLIEIESYLQSGKHI MNAIIIDDHPLAIAAIRNLLIKNDIEILAELTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQVLETLRKRQYSGIIIIVSAKNDHFYGKHCADAGANGFVSKKEGMNNIIAAIEAAKNGYCYFPFSLNRFVGSLTSDQQKLDSLSKQEISVMRYILDGKDNNDIAEKMFISNKTVSTYKSRLMEKLECKSLMDLYTFAQRNKIG 107.35 gnl|BL_ORD_ID|939|hsp_num:0 1015 Z1_02633 Response regulator UvrY Loose 390 52.0 evgA 23.65 3000832 protein homolog model n/a n/a macrolide antibiotic; fluoroquinolone antibiotic; penam; tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump MINTLVISQVEIFSLGIEKLLCQIKKINIRKIMNDESEAFRYCRQYSVNLIIFYSLPTVSLIDVIKRIKRFSPIIKIVVISPKIDSILSVTLLQLGIEGFIVIDSSAANVLQAIRQICIGQRYISPEIAMDIALTKVQADLNPLHHLSERELQIMSMIIRGKKIAQIAQELNISTKTVNSYRYRMFSKLKISGDVELTHIAVRYGLIEIESYLQSGKHI MNAIIIDDHPLAIAAIRNLLIKNDIEILAELTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQVLETLRKRQYSGIIIIVSAKNDHFYGKHCADAGANGFVSKKEGMNNIIAAIEAAKNGYCYFPFSLNRFVGSLTSDQQKLDSLSKQEISVMRYILDGKDNNDIAEKMFISNKTVSTYKSRLMEKLECKSLMDLYTFAQRNKIG 107.35 gnl|BL_ORD_ID|939|hsp_num:0 1015 Z1_02645 Sugar efflux transporter Loose 700 127.5 cmlv 27.3 3002700 protein homolog model n/a n/a phenicol antibiotic antibiotic inactivation chloramphenicol phosphotransferase MNITTPNSVNEVSRKTAWIRVIILSFAAFVFNTTEFVPVALLSNISESFAMVPAQTGLMITIYAWVVALMSLPLMIMTSKVERRKLLIILFIVFILSHVLSGVAWDFNSLIVGRVGVAFAHAVFWSITASLAIRMAPHGKKAQALSLLATGVALATVLGLPLGRVVGQWLGWRATFLGIGVLALITMLALMRYLPLLPSEHSGSLKSVPILLKRAPLVGIFLLTVIAVTAHFTAYSYIEPFVIDIAKLDENFATIVLLIFGGAGILGSVLFSRYSTKMPTSFLFFALILLTVCLSTLMMSSQHTLTFIALIIFWGIGFMCIALGLQVKVIDLAPDATDIAMSIYSGIFNIGIGAGALLGNQVILHAGMPNIGYAGTALSIIALAWCGFIFTRYRVAMGGKPREKNRLH MPSPSAEPTTSTPTPDAGPAASPRMPLAVYILGLSAFALGTSEFMLSGLVPPIAEDMNVSIPRAGLLISAFAIGMVVGAPLLAVATLRLPRKTTLIALITVFGLRQMAGALAPNYAVLFASRVISALPCAGFWAVGAAVAIAMVPVGSRARALAVMIGGLSIANVLRVPAGAFLGEHLGWASAFWAVGLASAIALVGVVTRIPRIPLPETRPRPLKNEVAIYRDRQVLLSIAVTALAAGGVFCAFSYLAPLLTDVSGLDEAWVSGVLGLFGIGAVVGTTIGGRVADAHLFGVLLTGISASTVFLVALALFASNPAATIVLTFLLGVSAFYTAPALNARMFNVAGAAPTLAGATTTAAFNLGNTGGPWLGGTVIDANLGFASTAWAGAAMTVLGLGTAALALRLTKRPAPGHVVARSRGAGGTTPSEPARGKATSSC 93.58 gnl|BL_ORD_ID|650|hsp_num:0 703 Z1_02646 Multidrug transporter EmrE Strict 75 83.2 qacJ 37.25 3007014 protein homolog model n/a n/a disinfecting agents and antiseptics antibiotic efflux small multidrug resistance (SMR) antibiotic efflux pump MNGLTYLILAIISEVIATTVLKASDGFSRLYPSIVVVVGYCFSFWALSQVVKVMPLGIAYAIWSGLGIVLVSVAAVFVYQQKLDLPAIVGMTLIIAGVLVINLLSNSTSH MPYLYLVIAIITEIIGTSFLKTAEGFTKLWPTLGTLISFGICFYFLSVTMKYLPLNVSYATWAGLGLVLTTIVSVVIFKESVNLISIFSIILIIIGVVLLNVFGSSH 102.80 gnl|BL_ORD_ID|4668|hsp_num:0 5730 Z1_02652 Alanine racemase, catabolic Loose 175 167.5 vanT gene in vanG cluster 32.34 3002972 protein homolog model n/a n/a glycopeptide antibiotic antibiotic target alteration glycopeptide resistance gene cluster; vanT MSRPAKISINLDALSHNLSVIKSKAQGSKVWSVVKADAYGHGLSCVWPALSHTDGFALIELDKAIMLREQGWVGPILLLEGFFKPDDVYLLERYSLTTVVHADWQFEAIEQAQLERPINIYLKLNSGMNRLGYRPENYQQAIQRAKRITNIGSIVQMSHFANADSGLNMATQKQIIDSSMVNDLPRCLANSAAILFEPQTYHSWVRPGIILYGVSPSGVWQDIADFDLQPVMTFNSEVLAIQSVKKGEQIGYGSRYTAQRDMRIAVVACGYADGYPRHAPDGTPVIVKGHKTQLVGRISMDMLTIDVTDLPDVEHGSPVELWGNQLPVDEVALACGTIGYELLCAIAPRVAVEVTINVANSTFSDLNESC MTKNESYSGIDYFRFIAALLIVAIHTSPLSSFSETGNFIFTRIVARVAVPFFFMTSGFFLISRYTCNAEKLGAFIKKTTLIYGVAILLYIPINVYNGYFKMDNLLPNIIKDIVFDGTLYHLWYLPASIIGAAIAWYLVKKVHYRKAFLIASILYIIGLFGDSYYGIVKSVSCLNVFYNLIFQLTDYTRNGIFFAPIFFVLGGYISDSQNRLSLKRSIVGFIVCFALMFGEALTLHHFDIQKHDSMYVLLLPSVYCLFNLLLHFRGKRRTGLRTISLIIYIIHPFMIVVIRLFAKLLHLQSLLVENSLVHYIAVCFASVVLAVVITALLSSLKPKKAKHTADTDRAYLEINLNNLEHNVNTLQKAMSPKCELMAVVKAEAYGHGMYEVTTYLEQIGVSSFAVATIDEGIRLRKYGISSEILILGYTSPSRAKELCKYELTQTLIDYRYSLLLNKQGYDIKAHIKIDTGMHRLGFSTEDKDKILAAFSLKHIKVAGIFTHLCAADSLEENDVAFTNKQIGSFYKVLDWLKSSGLNIPKVHIQSSYGLLNYPELECDYIRVGVALYGVLSSTNDKTKLELDLRPVLSLKAKVVLIRKIKQGESVGYSRAFTATRDSLIAILPIGYADGFPRNLSCGNSYVLIGGRQAPIVGKICMDQLAVDVTDIPNVKTGSIATLIGKDGKEEITAPMVAESAESITNELLSRMGHRLNIIRRA 51.97 gnl|BL_ORD_ID|1525|hsp_num:0 1561 Z1_02670 Regulator of RpoS Loose 420 58.2 mtrA 31.07 3000816 protein homolog model n/a n/a macrolide antibiotic; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MNKALVGKKILIIDDEVVFRTMLTEYFSHEKACVYATDNGSQALLLLEEGLRPDLILCDIRMPVMNGPTFLCHLEQRHWSFPVIAISCTDNMAEIDDMLRFGAQDVFLKPVTNLAKLKQKVIEVLCPGFFESELIARGQLGPLWNNLREQPHYIQSFVKQMQPQVKQIVAGYNVNYRQLNDASQMGLLFDIATLSKDQIIFYCVDVSNDEENGLLVALLLRVVFNRFLKATEKRRFLPSMYNILNKINKMLEDMGVRGSFPLILGYYHTKEKNILLASAGLRAEIKTENKKYVLNSGIPLGTLHSLYINQIKCVGIDWQCKIWNQHHKINLMFSPIHKR MDTMRQRILVVDDDASLAEMLTIVLRGEGFDTAVIGDGTQALTAVRELRPDLVLLDLMLPGMNGIDVCRVLRADSGVPIVMLTAKTDTVDVVLGLESGADDYIMKPFKPKELVARVRARLRRNDDEPAEMLSIADVEIDVPAHKVTRNGEQISLTPLEFDLLVALARKPRQVFTRDVLLEQVWGYRHPADTRLVNVHVQRLRAKVEKDPENPTVVLTVRGVGYKAGPP 148.68 gnl|BL_ORD_ID|1434|hsp_num:0 1559 Z1_02672 UDP-N-acetylglucosamine 4-epimerase Loose 1200 62.0 arnA 25.3 3002985 protein homolog model n/a n/a peptide antibiotic antibiotic target alteration pmr phosphoethanolamine transferase MKILVTGAAGFIGYHLSQRLIEMGYHVIGIDNLNDYYDVRLKEARLAKLNQLDNFQFEKIDITDSVSIAQLFADHRFDRVIHLAAQPGVRYSIENPMAYIDANIVGHINILEGCRHHNVGHLIYSSSSSVYGLNQKQPFSTEDSVDHPVSLYAATKKANELMSHSYSHLYQLPTTGLRFFTVYGPWGRPDMALFKFTKAMLAGEPIDVYNGGNMTRDFTYVDDIVSSVVRLINIIPQPNPNWTVEQGETSSSSAPYKIYNVGNGQPTKLMDFITAIEKSLNIKAKLNLMPMQDGDVLSTCANCSDLAQTTGFSPNTAVEYGVKQFVDWYVDYYQQ MTSKAVVFAYHDIGCTGIEALLNAGYEIAAVFTHADDPRENTFYASVARLCAERGIPLHAPEDVNHPLWLERIRQLRPDFLFSFYYRRLLGAELLACAARGAYNLHGSLLPRYRGRAPANWVLVNGETQTGVTLHRMIERADAGPILAQQAVAIDPEDTALSLHGKLRKAAGALLRDSLPLLALGVLPEVEQDESQASHFGRRTPADGLLDWHRPARQLYDLVRAVTQPYPGAFCQVGEQKLIVWSAEVVAGNHGREPGSVLSCDPLRIACGEDSLVLRFGQRGERGLYLAGTQLATELGLVEGARLRGAACSPQRRTRVLILGVNGFIGNHLSERLLRDGRYEVHGMDIGSDAIERLKADPHFHFVEGDIGIHSEWLEYHVKKCDVILPLVAIATPIEYTRNPLRVFELDFEENLRIVRYCVKYGKRVVFPSTSEVYGMCQDPDFDEDRSNLVVGPINKQRWIYSVSKQLLDRVIWAYGQQGLRFTLFRPFNWMGPRLDRLDSARIGSSRAITQLILHLVEGTPIRLVDGGAQKRCFTDVDDGIEALARIIDNRDGRCDGQIVNIGNPDNEASIRQLGEELLRQFEAHPLRAQFPPFAGFREVESRSFYGDGYQDVAHRKPSIDNARRLLDWQPTIELRETIGKTLDFFLHEALREREAQA 50.60 gnl|BL_ORD_ID|1516|hsp_num:0 1643 Z1_02673 DNA-binding protein H-NS Loose 240 200.3 H-NS 79.26 3000676 protein homolog model n/a n/a macrolide antibiotic; fluoroquinolone antibiotic; cephalosporin; cephamycin; penam; tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump MSESLKILNNIRTLRAQARETSLETLEEMLEKLEVVVNERREEEQAMQAEIEERQQKLQKYRELLIADGIDPTDLLEAAGASKTGRAKRAARPAKYSYVDDNGETKTWTGQGRTPAVIKRAIEEEGKSLEDFLI MSEALKILNNIRTLRAQARECTLETLEEMLEKLEVVVNERREEESAAAAEVEERTRKLQQYREMLIADGIDPNELLNSLAAVKSGTKAKRAQRPAKYSYVDENGETKTWTGQGRTPAVIKKAMDEQGKSLDDFLIKQ 97.81 gnl|BL_ORD_ID|1147|hsp_num:0 1248 Z1_02677 Oligopeptide transport ATP-binding protein OppF Loose 570 99.8 bcrA 33.33 3002987 protein homolog model n/a n/a peptide antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MLIDIHHLRVQFEQNRQIKQVVKGVNLQVKQGETFSLIGRSGCGKSTVLRVIAGLLHHWQGDIKLLGQAIKPQQRFQGKLRRNIQMVFQDPYASLHPQHRIERAFIEPLKIHHIAYDKTTITSALEQVGLEGDIAYRYPHQLSGGQRQRVAIARALLLQPQLLLLDEPTSALDMSVQAEILNLLNTLKKQHNMTYLLVSHDADVIAHMSDSAALMEEGQLTCYYDRKALSQGLHRLD MSTIIKTTDLTKMYGSQKSVDHLNINVKQGDIYGFLGRNGAGKTTTIRMLLGLIKPTSGQIEIFGENFFKNKKEILRRIGSIVEVPGFYANLTARENLLINAKIIGIHKKNAIDEVLEIVGLQHETKKLVGKFSLGMKQRLGIARALLHYPELLILDEPTNGLDPIGIKEMRRLIHSLAKERNITIFISSHILSEIEQLVDHVGIIHEGKLLEEIPFDHLKKRNRKYLEFQLSDQNKAVVLMEQHFDIHDYEVHQDGIIRVYSHLGQQGKLNKLFVENGIDVLKITMSEDSLEDYFVKLIGGGTIG 77.45 gnl|BL_ORD_ID|316|hsp_num:0 345 Z1_02678 Dipeptide transport ATP-binding protein DppD Loose 1280 77.8 macB 29.3 3000535 protein homolog model n/a n/a macrolide antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MNKAPLIEVDNLCIDFPRARVVNNVSFQLGQERLALVGESGSGKSMTARSLMGLVRKPGKVSADKLHFMGDDLLAYSPKQWNQLRGKTISMVLQDPRYALNPVKTIYQQVEETVKLHQKLSHKDRHALITETLLSVGLPEQSISRYPGELSGGMGQRAMIAIALINNPTVLIADEPTSALDAQLRHQILELIITQCAQRDMALLLISHDLPLVAEYCDRVMVMYQGEQVDELEAKALPQATHPYTRTLWTCRPNASTYGTQLPVLDRTLNFKGTPYAN MSLIECKNINRYFGSGENRVHILKDISLSIEKGDFVAIIGQSGSGKSTLMNILGCLDTAGSGSYRIDGIETAKMQPDELAALRRERFGFIFQRYNLLSSLTARDNVALPAVYMGMGGKERSARADKLLQDLGLASKEGNKPGELSGGQQQRVSIARALMNGGEIIFADEPTGALDTASGKNVMEIIRRLHEAGHTVIMVTHDPGIAANANRVIEIRDGEIISDTSKNPEIPASNVGRIQEKASWSFYYDQFVEAFRMSVQAVLAHKMRSLLTMLGIIIGIASVVSVVALGNGSQKKILEDISSMGTNTISIFPGRGFGDRRSGKIKTLTIDDAKIIAKQSYVASATPMTSSGGTLTYRNTDLTASLYGVGEQYFDVRGLKLETGRLFDENDVKEDAQVVVIDQNVKDKLFADSDPLGKTILFRKRPLTVIGVMKKDENAFGNSDVLMLWSPYTTVMHQITGESHTNSITVKIKDNANTRVAEKGLAELLKARHGTEDFFMNNSDSIRQMVESTTGTMKLLISSIALISLVVGGIGVMNIMLVSVTERTKEIGIRMAIGARRGNILQQFLIEAVLICIIGGLVGVGLSAAVSLVFNHFVTDFPMDISAASVIGAVACSTGIGIAFGFMPANKAAKLNPIDALAQD 43.17 gnl|BL_ORD_ID|447|hsp_num:0 487 Z1_02689 Oligopeptide transport ATP-binding protein OppD Loose 1280 87.0 macB 30.41 3000535 protein homolog model n/a n/a macrolide antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MTNSTNKPLLSVKDLCVTFGTPDGDVTAVNKLNFELSAGETLGIVGESGSGKSQTAFALMGLLAKNGRTAGSAHFNGREILNLRQSQLNKMRAEEISMIFQDPMTSLNPYMKVGTQLIEVLMLHKGMSKNDAYAESVRMLDAVKMPEAHKRMGMYPHEFSGGMRQRVMIAMALLCKPKLLIADEPTTALDVTVQAQIMTLLNELKKELNTAIIMITHDLGVVAGICDKVLVMYAGRTMEYGNARDIFYQPSHPYSIGLLQAVPRLDGEDERLATIPGNPPNLLRLPKGCPFQPRCQYATEQCLNSEPQLTQFAQGRLRACFKAAEELV MSLIECKNINRYFGSGENRVHILKDISLSIEKGDFVAIIGQSGSGKSTLMNILGCLDTAGSGSYRIDGIETAKMQPDELAALRRERFGFIFQRYNLLSSLTARDNVALPAVYMGMGGKERSARADKLLQDLGLASKEGNKPGELSGGQQQRVSIARALMNGGEIIFADEPTGALDTASGKNVMEIIRRLHEAGHTVIMVTHDPGIAANANRVIEIRDGEIISDTSKNPEIPASNVGRIQEKASWSFYYDQFVEAFRMSVQAVLAHKMRSLLTMLGIIIGIASVVSVVALGNGSQKKILEDISSMGTNTISIFPGRGFGDRRSGKIKTLTIDDAKIIAKQSYVASATPMTSSGGTLTYRNTDLTASLYGVGEQYFDVRGLKLETGRLFDENDVKEDAQVVVIDQNVKDKLFADSDPLGKTILFRKRPLTVIGVMKKDENAFGNSDVLMLWSPYTTVMHQITGESHTNSITVKIKDNANTRVAEKGLAELLKARHGTEDFFMNNSDSIRQMVESTTGTMKLLISSIALISLVVGGIGVMNIMLVSVTERTKEIGIRMAIGARRGNILQQFLIEAVLICIIGGLVGVGLSAAVSLVFNHFVTDFPMDISAASVIGAVACSTGIGIAFGFMPANKAAKLNPIDALAQD 50.93 gnl|BL_ORD_ID|447|hsp_num:0 487 Z1_02690 Vitamin B12 import ATP-binding protein BtuD Loose 500 106.7 RanA 29.0 3005091 protein homolog model n/a n/a aminoglycoside antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MSQATLQDRKVILEVNDLKVYFDVQDNKQWFWQPKKSLKAVDGVTLRLYEGETLGVVGESGCGKSTFARAIIGLVKASGGTVTWLGNDLLGMGNKQWRDVRQDIQMIFQDPLASLNPRMTIGDIIAEPLKTYHPKMKQAEVVEKVKAMMMRVGLLPNLINRYPHEFSGGQCQRIGIARALILEPKLVICDEPVSALDVSIQAQVVNLLKDIQKEMGLSLIFIAHDLAVVKHISDRVLVMYLGHAVELGTYDEVYHHPLHPYTKALMSAVPIPDPDKERNKHIDLLEGELPSPINPPSGCIFRTRCPMADEECAKTRPLLEGSFRHAVSCLKVDPL MIEVKDLRKSFNDVEVLKGITTTFETGKINLVIGQSGSGKTVFLKCLLNVFDPSSGDILFDGRNLSIMGRTEKQEIRSEIGTVFQGSALFDSMTVEENISFPLDMFTNLTYTEKRKRVKEVIGRVHLENANTKFPSEISGGMQKRVAIARAIVNNPKYLFCDEPNSGLDPNTAIVIDELIKEITEEYNTTTIINTHDMNSVLTIGEKIVYLRKGVKEWEGNKDLIIKAENEHLIDFVYSSALFKQVRETMLRNNQTNL 129.84 gnl|BL_ORD_ID|2817|hsp_num:0 3825 Z1_02731 Hemin import ATP-binding protein HmuV Loose 650 77.0 tetA(58) 28.7 3003980 protein homolog model n/a n/a tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MMENQHTPLLYGNNLSYKIGNKTILEDVSIALNTGELITIIGPNGAGKSSLLRLLTGYTPPTQGECFFKGKTYSQWNSQLLAQNRAVMRQNSQLSFSFSVEEVVAMGRAPHGQKHKQIAIETALLQTNCLKLKTRDYRQLSGGEQQRVQLARVLAQLWQPTPENVALFLDEPTSALDLYHQQQSLRLLKQLVKTQNLMVCCVLHDLNLASLYADRILLLHQGKLVCEGTPQDVLTAENIEKWYGAEVSVNTHPELSQPQVFLRP MEHAYKKKIEPKPGDLAVEAYGLIKTFGDNRAVDGVDLNVRTGTIYGVLGPNGAGKTTTIRMLATLLRPDAGSARIFGHDVQAESQIVRQLIGVTGQYASVDESLSATENLIIFSRLLGLGRKEARRKAEELLEEFGLSEAAKRPLKNFSGGMRRRLDLAASLIAQPPLIFLDEPTTGLDPRTRSQMWDTIRRLVNTGSTVLLTTQYLEEADQLADRIAVIDYGRVVAEGTADELKMSVGTSSLHLTVEDSVDMDRACHTVEQVLGVHANVSPEAGKITAPMANAGLVTDLLIELRTAGIGLSEMSVQKPTLDEVFLTITGHGVKEDAAQESYESNDREVARV 76.97 gnl|BL_ORD_ID|2251|hsp_num:0 2517 Z1_02740 Phosphoenolpyruvate synthase Loose 1500 185.3 rphB 36.83 3003992 protein homolog model n/a n/a rifamycin antibiotic antibiotic inactivation rifampin phosphotransferase MSSNSLTPCNVLWYNQLGMNDVDRVGGKNASLGEMITNLAELGVSVPNGFATTAQAFNDFLEQSGINQRIYELLDSIDVDDVNQLAQAGNQIRQWVIDTPFTPQFEKDIRDAYQTLSEGESEASFAVRSSATAEDMPDASFAGQQETFLNVQGIDAILVAIKHVFASLFNDRAISYRVHQGYDHRGVALSAGVQRMVRSDLASSGVMFTIDTESGFDQVVFITSAYGLGEMVVQGAVNPDEFYVHKPTLAKGLPAIVRRNLGSKKIQMVYADSIEHGKQVRIEDTPEALRNRFSLTDDEVQELAKQAVLIEQHYGRPMDIEWAKDGHNGRLYIVQARPETVRSNQQVMERYQLNETGTVIVEGRAIGHRIGSGTVKVIHNLSEMDRIEAGDVLVTDMTDPDWEPIMKKASAIVTNRGGRTCHAAIIARELGIPAVVGCGDATECISEGQVVTVSCAEGDTGFVYDGKLDFSIQSSAIDNMPELGLKIMMNVGNPDRAFDFAGLPNDGVGLARLEFIINRMIGVHPRALLEYEDQTDALKAEIDEMMAGYASPVEYYIGKLTEGIATLAAAFWPKRVIVRLSDFKSNEYANLVGGDRYEPDEENPMLGFRGAGRYVSDDFRRCFALECEAVKRVRNEMELTNVEVMIPFVRTVRQAEEVIDELARNGLKRGENGLKVIMMCEIPSNALLADQFLAHFDGFSIGSNDMTQLTLGLDRDSGVVSSLFDERNDAVKALLSMAIQSAKRQGKYVGICGQGPSDHEDFAQWLMEEGIDSLSLNPDTVIKTWVKLAQQ MRSLVLDFQEMDKKQLGLVGGKGLHLGELSKIEGIRVPEGFCVTTIGYQRAIEQNETYQAMLNRLTMLSAEDRDQMVEISRKIRQTIMEVEIPSDVVTAVTRYLSRFGEEQAYAVRSSATAEDLPHASFAGQQDTYLNIIGVDAILQHISKCWASLFTDRAVIYRMQNGFDHRQVYLSVVVQRMVFPEASGILFTADPMTSNRKLLSIDAGFGLGEALVSGLVSADGYKVREGEIIEKRIAAKTLAIYGRKEGGTETKQIDPDQQKSQTLTDEQILQLARIGRQIEAHFGQPQDIEWCLAQDTFYIVQSRPITTLYPIPEANDQENHVYVSVGHQQMMTDPMKPLGLSFFLLTTPAPMRTAGGRLFVDTTAMLASPVSRENVLNTLGQSDPLIKDALMTILERGDFIKSLPIAENEQTPGKNNISSAGYQTPIDHDPTIVSDLMERTQSSIEVLKQNIQTKSGSDLFDFILEDIQELKKNLFDPQSSAVIMAAMNASTWINEKMNEWLGEKNAADTLSQSVPGNVTSEMGLALLDVADVIRPYPEIIDYLEQAKDDHFLDKLLTFDGGQQAQDAILDFLDKYGMRCAGEIDLTRTRWSEKPIALVPLILGNIKNFEPNASHRKFEQGRQEALKKEQELLDRLKQLPDGEGKAQETKRMIDLIRNFMGYREYPKYGMVNRYFIYKQALLKEAERLVQAGVIHHKEDIYYLTFEELDEVVRTNKLDNPGSMVEQQAKLAIRQMISKRKEEYNVFEKLTPPRVITSDGEIIAGEYKRENIPAEAIVGLPVSSGTVEGRARVILNMKDADLEEGDILVTAFTDPSWTPLFVSIKGLVTEVGGLMTHGAVIAREYGLPAVVGVENATKRIKDGQRIRVHGSEGYIEILS 89.48 gnl|BL_ORD_ID|2243|hsp_num:0 2528 Z1_02747 putative ATP-dependent transporter SufC Loose 1150 72.0 tetB(46) 26.36 3004033 protein homolog model n/a n/a tetracycline antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MLDIKNLHVSVEGNEILKGLDLQVRAGEVHAIMGPNGSGKSTLSATLAGREEYEVDEGSVTFKNKDLLELEPEERAGEGIFMAFQYPVEIPGVSNQFFLQSSVNAVREYRGQEPLDRFDFEDFIEGKIKLLDMPQDLLTRSVNVGFSGGEKKRNDILQMAALEPELCILDETDSGLDIDALKIVANGVNSLRDGKRAFIVVTHYQRILDYIKPDYVHVLYQGKIIKSGDFSLAQKLEEQGYGWLIDPQ MKVLKRLLSRITLYPTVFLAGFICLLLATIFSELSPFLLQKMIDGPLTALTHGGGQGDLLQMGGFYLLVLSLGQLISYMGNRILLHGSNQVTASLRDQAFQVMQGLPISYFDDKPAGKIATRIVNDTETLRTQFYNSCMILVIYLVRFLFILGILFYLSPMMGLLLCLVFPIFYGIQYLYKVMTDQPMKDFFDARSEVNTQVNELLHGASMIQLYHQEPGVVEEFEATTQKMLGANDRILLADSIASWTLTELLKFLVIAGILTIAGISFLQGNIGVTAGFLFININYVINLFDLMANLSRQFPNIRRSLETGSRVLAFLDQPLEADGALELKIEKAEVVFDDVQFAYEEGKPVLKDISIQAHPGQTLALVGHTGSGKSSIMNLLYRFYDPQEGEIRIDGQNIRHFSRESLRSHMGIVLQDPYLFTGTIASNVAMSQEHIDRNAVKDALKKVGAWPFVERLEKGIDHPVVEKGSAFSSGERQLISFARTLYMNPQILILDEATSHIDTETEEIIQKAMAVLQKGRTTFIIAHRLSTIQDADQILVLSEGRIVERGQHADLVAHGGIYAQMQAIQQTVE 42.91 gnl|BL_ORD_ID|2317|hsp_num:0 2644 Z1_02760 Multidrug resistance protein MdtK Loose 900 400.6 hmrM 43.89 3003953 protein homolog model n/a n/a fluoroquinolone antibiotic; disinfecting agents and antiseptics antibiotic efflux multidrug and toxic compound extrusion (MATE) transporter MQKYIKEARSLLALGIPVIIAQFSQTAMGVVDTVMAGAVNATEMSAVAVGTSIWLPTILLGQGILMALTPIVAQLNGSGQRKHIANRTQQGFWLATFLSIMVIAILYNSRFIIEAQHDIEPELAEKAIGFIHAIMWGAPGCLYYQVLRSQCEGLSKTKPGMIIGFIGLLINIPVNYAFIYGKFGAPQLGGIGCGVATASVFWAMFLMMRYYVRRAPTQRDVMPKKRLVLPEFHTIKRITLLGLPVGLALFFEVTLFAVVALLVSPLGVTAVASHQIALNFSSLMFMFPLSLGIAATIRVGYNLGQRSTEQARTSAITALAVGLMLASCTAIFSIIFREKIALMYNDNIEVVTLASHLMLFAALYQLSDSVQVIGSGVLRGYKDTRSIFFITFIAYWVIGLPSGYLLGRTDYIVEAMGPAGFWIGFILGLTASAIMMGTRIWWIQRQSDEVVLLRSER MNFRLLSQYHTDIKKLIKISLPILLAQIAQNSMGLADTIMAGRVSSTDMAAISIGASIWMPLMFFGQGLLLALPPTISYLNGSGQHHRIAHQVRQGIWLVLGVSIPLGLLIYFCEIPLQYMQMESKMSDLARNYLHAMLWGLPAYLMLINFRCLNDGIEKTKPAMVITFLGLLINIPLNYIFIYGKFGMPAFGAVGCGIATAIVNWAMCLMMIFYSYTNTQERSLKVFSQLIEMPNPKTLKKLLRLGLPIAIAICCEVALYALTSLMLSPLGATIVASHQITLNTSSFIFMFPMSIGMATTILVGQALGAGSPQNAKKIGYAALLLGLTVTIVTALITIFFRYEIASIFVTDEIVIAMAANLLLFAALYQFSDTIQMVVGGILRGYKDTKVILYITLFSYWVIGVPLGYTLGRTDWLVPHIDAKGFWIAFVVSLTFAAFLLSLRMKKMQAMNDNAILQRLEKLK 98.49 gnl|BL_ORD_ID|2194|hsp_num:0 2425 Z1_02763 Inner membrane transport protein YdhC Loose 500 119.4 bcr-1 28.8 3003801 protein homolog model n/a n/a bicyclomycin-like antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MTLKNSTQSKTPSLFMVYLACLSMLGYLAIDMYLPAFGMMQRELSISEGAVSNSLSIFLFGFAVAQLLWGPLSDKLGRKPILLIGLSFFSLGCLGMLWVDSAAGLLTMRFLQAFGVCSAAVIWQALVIDRFDESRAQHVFASIMPLVALSPALAPLIGAFLLNHGGWRMIFMLLMAITLVLMLPTLMLKNIKQKSVIDAGPSTVSFLTLLKSPIYAGNVLVYASCSAGFFAWLAGSPIILEKMGYSPQDIGLSYIPQTIAFMVGGYGCRILLSKMSGKTLLPLLLIGYAVSMTALFLVAKYTHPTLTTILIPFCIMAVMNGASYPIAVSNALSAYPEVSGKAAALQNALQLGLCSLASFIVSAFISQQPLINTTAIMALTAIPMALGYFIQRNKSVSKHTVQATE MPASASRIQVGSGERRLLLLLSALVAFGPLSIDMYLPSLPAIAADLGASDAQVQRSISGFLVGFCVGMLFYGPLSDRFGRRPVLLAGIALYLFSSLACALADSAGQLVLLRVLQALGGGAASVLARAMVRDLYPLGEAARMLALMHMVTMLAPLAAPLLGGYLMLWAGWRALFVVLALFAGLCLLAVWRVAESHPPERRGGSLAQAFLAYGRLLGDRRALGYVLCMGLAFAGMFAYISAAPFVFIEHFGVRAERFGWFFGLNILGVMLATWCSARLVRRHGPRPLLRAGSLLACVSGLFLLGYAALGERGGLWALVPGLLCFVSVTGLLGANCIASLLALYPGQAGAASAVAVSGQFGLGCLASLAVGWLALPGVLPMALVMAVCGVGSLLALGLALHGGNR 100.75 gnl|BL_ORD_ID|2340|hsp_num:0 2303 Z1_02764 HTH-type transcriptional activator AllS Loose 650 57.0 adeL 30.65 3000620 protein homolog model n/a n/a fluoroquinolone antibiotic; tetracycline antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MWSEYSLEVVDAVARTGSFSSAAQELHRVPSAVSYTVRQLEEWLAVPLFERRHRDVELTDAGKIFIKEARSVIKKMNDTRHMCQQVSNGWRGQFSIAVDGIVKPARTQQLILDFYRHFPDIELYVYPEVFNGVWDSLVNGRVDLAIGATRASPIGERYSFKDMGFMPWRCVCHAEHPLASAAHPLTDDELRPYPSLCLEDTSRSLPKRDTWALNNQRRMIVPSWDMGLECLLAGLCVGMVPWHRAEPLIEQGKLVTLTLAQPLPDSPCCLTWVDKSESPALTWLLDYLGDSQTLNEEWLR MRVFNKVVETNSFSLAADSLGLPRASVTTTIQALEKHLQVRLLNRTTRKISLTPDGAVYYDRTARILADVADIESSFHDAERGPRGQLRIDVPVSIGRLILIPRLRDFHARYPDIDLVIGLNDRPVDLVGEAVDCAIRVGELKDSSLIARRIGTFQCATAASPIYLEKYGEPTSIEDLQKNHKAIHFFSSRTGRNFDWDFVVDDLIKSVSVRGRVSVNDGDAYIDLALQGFGIIQGPRYMLTNHLESGLLKEVLPQWTPAPMPISAVYLQNRHLSLKVKVFVDWVAELFAGCPLLGGTALPFDQKCEFACDKETGHEYTIRTLVEQHNIAEAYTLKT 89.02 gnl|BL_ORD_ID|2323|hsp_num:0 2654 Z1_02775 Transcriptional regulator SlyA Loose 250 40.8 mepR 27.1 3000746 protein homolog model n/a n/a glycylcycline; tetracycline antibiotic antibiotic efflux multidrug and toxic compound extrusion (MATE) transporter MESTLGADLARLVRLWRALIDHRLKPLKLTQTHWVTLYNISQLPPEQSQIQLAKAIGIEQPSLVRTLDQLEEKKLICRHTCSSDRRAKRITLTKESEPFISEVYAVIEKTRQEILSGIKKEEIDNLIYLIKKLEKNIIRLHD MEFTYSYLFRMISHEMKQKADQKLEQFDITNEQGHTLGYLYAHQQDGLTQNDIAKALQRTGPTVSNLLRNLERKKLIYRYVDAQDTRRKNIGLTTSGIKLVEAFTSIFDEMEQTLVSQLSEEENEQMKANLTKMLSSLQ 102.16 gnl|BL_ORD_ID|792|hsp_num:0 856 Z1_02783 Peptide transport system ATP-binding protein SapF Loose 1100 91.3 tetB(60) 33.33 3004036 protein homolog model n/a n/a tetracycline antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MFDKLLEVKNLSKTFRYRTGLFHRQQLKAVKPVSFTLEPKQTLAIIGANGSGKSTLARMLSGVTEPTGGDIFINGHQLSFGDYSYRSQRIRMIFQDPTNSLNPRQRIGQTLDLPLRLNTELSGIEREKRIYQTLRQVGLLPEHANYYPHMFASGQRQRIALARALILQPQVIIADEAIASLDMSLRSQIINLMLELQETHEIAYIYVTQNLGMTKHISDKVMVMDNGEVVERGNTAEVLASPLHEVTRRLVASHFGEALTAEAWRQDLP MRTMKRLLSYLRYEKKGVLIGLFCLLLSTGATLTGPLVAKHIIDNVITPMGQAHDFKAGGLLLWVGIYVTVNLVGVAGAYLNRVYMKTLSNRIAKRIRDEVFEHVQTLPVSYFDHLPAGKVVSRITSDTESVRANFYVSGISTLFSTIVMLVGVYITIFLLNATLGLVLLFLVPVMILWQRTVATKQKKYYSENRELYSQLSGQLNESIQGAGIVQAFQQEEKIVAEYDATATSWVEVGRKELILESYFSWSLVGMLRNITHFGVIYYFSMQFIGGTLGISAGLLYAFIDYINRIYEPIQTFMNVVSGFQQSMAAGDRVFELMDTPSEESGEELFTFDEGCIEFKDVSFEYTAGVPVLKHLNFTVEPGQTVAFVGHTGSGKSSIMNLLFRFYDPTSGAIFIDGKNTRDFNRRSVRSEMGIVLQDPYLFTGTIASNVGLNNESIEPETIKEAIIKVGGGHLLTKSDKGLDYEVKEKGMDFSSGERQLISFARAIVFDPKILILDEATSHIDTETEEIIQNAINVVKEGRTTFMIAHRLSTIAHADQIFVLDKGEIVERGTHDELLQLQGQYAEMVALQKG 46.46 gnl|BL_ORD_ID|2315|hsp_num:0 2646 Z1_02784 Putrescine export system ATP-binding protein SapD Loose 1280 75.9 macB 25.57 3000535 protein homolog model n/a n/a macrolide antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MPLLDIRNLTIEFMTPDGPVKAVDRVSITLSEGEVRGLVGESGSGKSLIAKAICGVTKDNIKVTADRFRFDDIDLLKLSPRARRRVIGHNVSMIFQEPQSCLDPATKIEHQLIQAIPGWTFKGHWWQRFHWRKRRAIELLHRVGIKDHKDIMRSYPYELTEGECQKVMIAIAIANQPRLLIADEPTNAMEPATQTQIFRLLTRLNQNNNMTILLISHDLQWMSKLASKITVMYCGQTVETAIPEELLVTPYHPYTQALIRSIPDFTNSLPHKSRLNTLPGAIPSLEHLPVGCRLGPRCPYAQRQCIEAPRLRAFKNHAVACHFPLNVETTDVR MSLIECKNINRYFGSGENRVHILKDISLSIEKGDFVAIIGQSGSGKSTLMNILGCLDTAGSGSYRIDGIETAKMQPDELAALRRERFGFIFQRYNLLSSLTARDNVALPAVYMGMGGKERSARADKLLQDLGLASKEGNKPGELSGGQQQRVSIARALMNGGEIIFADEPTGALDTASGKNVMEIIRRLHEAGHTVIMVTHDPGIAANANRVIEIRDGEIISDTSKNPEIPASNVGRIQEKASWSFYYDQFVEAFRMSVQAVLAHKMRSLLTMLGIIIGIASVVSVVALGNGSQKKILEDISSMGTNTISIFPGRGFGDRRSGKIKTLTIDDAKIIAKQSYVASATPMTSSGGTLTYRNTDLTASLYGVGEQYFDVRGLKLETGRLFDENDVKEDAQVVVIDQNVKDKLFADSDPLGKTILFRKRPLTVIGVMKKDENAFGNSDVLMLWSPYTTVMHQITGESHTNSITVKIKDNANTRVAEKGLAELLKARHGTEDFFMNNSDSIRQMVESTTGTMKLLISSIALISLVVGGIGVMNIMLVSVTERTKEIGIRMAIGARRGNILQQFLIEAVLICIIGGLVGVGLSAAVSLVFNHFVTDFPMDISAASVIGAVACSTGIGIAFGFMPANKAAKLNPIDALAQD 51.71 gnl|BL_ORD_ID|447|hsp_num:0 487 Z1_02788 Psp operon transcriptional activator Loose 400 169.5 TxR 31.69 3005008 protein homolog model n/a n/a tetracycline antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MQENLETIIGVDSHFIDVLEQTSALAQLKKPVLIIGERGTGKELIAHRLHYLSPWWQGPFISINCSALNDNLLDSELFGHEAGAFTGAKNRHQGRFERADGGSLFLDELATAPMLVQEKLLRVIEYGHLERVGGSQSLHVDVRLICATNADLPAMADEGKFRADLLDRLAFDVIRLPPLRERKADIMLLAENFAIAMCQELGLPFFPGFSDNARQILLDYRWPGNIRELKNVVERSVYRHGTSERELDNIIIDPFARFSSSTIAEQPQPQKEMIFSLPPLPLDLRQWQHSTEKNLLEQALKESRYNQKMAAEKLALSYDQLRGLIKKHHIKLSV MKVQKCKATIHRRSLDADPLLPLIGNSTCISELRNKLKKYAQCDAEVLIQGETGVGKGMCARIIHELSSRHIYPFVEVNCGAIPSGLIASELFGHEKGAFTGAISDRIGFIQKANKGTLFLDEIGDMPPDLQIHLLHFLESKQIHKVGADKIIDVDCRVIAASHVDLKSEVIQGGFREDLFYRQNILPLTIPPLRKRGEDTVILSERFLEELSNGKVQSMSPEVKKKLLKHKWPGNVRELRNVIQRAIVMCEDNTLHIADLGLDNNERQLLPSVEQIDLDYLLKAIEDNKHNMSAAARNLGISRTTLYRLIKKYNLPI 105.03 gnl|BL_ORD_ID|4730|hsp_num:0 3753 Z1_02796 Transcriptional regulatory protein TyrR Loose 400 203.0 TxR 37.13 3005008 protein homolog model n/a n/a tetracycline antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MRLEVTCKDRIGLTRELLDLLVLKNIDLRGIEIFPIGLIYLNFSQIDFNIFQPLMAEIRRIEGVIDVRTVAFMPSEQEHRAMWTLLESVPVPVFSINTKGQIKLLNPATRHLFELDENDKNEKSFNQLIPNFNIHRWLEQKDPHAEIISIKLKKQHFDMEIVPIKLTDDNQFNHCVGALILLKYRGIIHEHPKLIVNDNSGFEQVIAVSTPMKQLVERAKKMAKMDDPLLLVGDTGTGKDLFAKACHLLSPRAREPFLGLNCASMPDDVVESELFGYAAGAYPNAIEGKKGFFEQANRGTVLLDEIGEMSPQMQIKLLRFLNDGTFRRVGEEHEVKVDVRIICATQKNLWELVQKGLFREDLYYRLNVLTLTLPPLRERKADIMPLALHFINQYCLEQKASKPVISPDLSAYLVQYGWPGNVRQLRNTIYQAMAQLVGNTLRPQDIALPEHTADTLFDEDLLEGSLDEMTKRFEASILRRLYRDYPSTRKLAKRLGISHTAIANKLREYDLTSKKADKTEK MKVQKCKATIHRRSLDADPLLPLIGNSTCISELRNKLKKYAQCDAEVLIQGETGVGKGMCARIIHELSSRHIYPFVEVNCGAIPSGLIASELFGHEKGAFTGAISDRIGFIQKANKGTLFLDEIGDMPPDLQIHLLHFLESKQIHKVGADKIIDVDCRVIAASHVDLKSEVIQGGFREDLFYRQNILPLTIPPLRKRGEDTVILSERFLEELSNGKVQSMSPEVKKKLLKHKWPGNVRELRNVIQRAIVMCEDNTLHIADLGLDNNERQLLPSVEQIDLDYLLKAIEDNKHNMSAAARNLGISRTTLYRLIKKYNLPI 163.84 gnl|BL_ORD_ID|4730|hsp_num:0 3753 Z1_02837 HTH-type transcriptional regulator CysB Loose 550 40.0 NmcR 27.59 3003665 protein homolog model n/a n/a carbapenem; cephalosporin; cephamycin; penam antibiotic inactivation NmcA beta-lactamase MKLQQLRYIVEVVNNDLNVSTTAERLYTSQPGISKQIRMLEDELGIQIFSRSGKHLTHVTPAGEEIVRLSREILSKTEAIRSAAGEHTYPDRGSLSIATTHTQARYVLPPVIKGFIERYPEVSLHMNQGSPTQIAEDVCRGKSDFAIATESLHLYNDLVMLPCYRWNRIVVVTKDHPLAQKREVTLQELATYDIVTYTHGFTGRSDLDEAFGKVGLKPKIVFTATDADVIKTYVRLHLGIGVIASMAFDPMLDSDLVAIDMRDKFSYSTTKIAFRRSGFLRGYMYDFMWRFAPHLTRNLVEQATALRTNEEIEELFKDIELPLV MRARLPLNALRAFEASARYLNFTKAGLELHVSQAAVSQQVRTLEQMLGVALFTRVPRGLQLTDEGMHLLPSITEALQMMSSAMDKFHEGKIKEVLTIAVVGTFAIGWLLPRITAFLNENPWIDIRILTHNNVVNLAAEGIDASIRFGTGGWINTENILLFQAPHTVLCSPETSKKLYIPSDLKKVCLLRSYRKEEWNNWFKAAGIDPWTITGPIFDSTRLMIDAVKLGDYAALVPYHMFQKELNERSVAKPFEIYATLGGYWLTLQKSRVNHNSEALNVFKEWIIEHSREFVLKS 109.83 gnl|BL_ORD_ID|1908|hsp_num:0 2072 Z1_02865 Inner membrane transport protein YnfM Loose 900 56.2 QepA4 29.94 3004379 protein homolog model n/a n/a fluoroquinolone antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MDTHEISSKNMALKEDVSINTTSKPNSPKHYIQRDDALYIKVTVSFFMVGLATFALLYFVQPILPILSKEFSVTPATSSLALSLSTGLMACGLLITGPLSDAFGRKNVMVIALFCAAFFTLLSAMMNSWTGILITRALVGLSLSGVAAVAMTYLSEEIHPAYLALSMGLYISGNSIGGMSGRVITGVLSDYYSWRVSVIILGIFALVAAIIFWRILPTSQHFRPATLKPRNLLITTKLHFRDKGLPLLFIEGGLLMGGFVTLFNYIGYRLLDAPYSLTQTTVGLISIVYLSGTYSASKAGLLTNKYGLGKVFIAGVSMMLAGILITLFDSLAIIFIGMLILTTGFFAAHAVASSWVGRRAKRGRAQASSLYLFTYYAGSSIAGTLGGIFWVNFGWLGVGLFIAFLMLTALLIALRLNQIAQ MSATLHDTAADRRKATRREWIGLAVVALPCLVYAMDLTVLNLALPVLSRELQPSSAQLLWILDIYGFFVAGFLITMGTLGDRIGRRRLLLIGAALFAFASVLAALADTAALLIAARALLGLAGATIAPSTMALIRNMFHDPRQRQFAIGVWIAAFSLGSAIGPLVGGVLLEFFHWGAVFWLNVPVMLLTLALGPRFLPEYRDPDAGHLDLASVLLSLAAVLLTIYGLKQLAEHGAGLASMAALLAGLAVGALFLRRQGHIAYPLLDLRLFAHAPFRAALAAYALAALAMFGVYIFMTQYLQLVLGLSPLQAGLATLPWSLCFVIGSLLSPQLAARWPAARILVVGLSAAAFGFAVLGLGQGLWWLVPATIVMGLGLAPVFTIGNEIIITSAPSERAGAASALSETVSEFSGALGIALFGSVGLVVYRQALTSAALPGLPADALQAAGASLGGAVHLADTLPAWQGAALLAAARAGFTDALQATAWAGAVLVLVAAGLVARLLRKRPALASG 82.39 gnl|BL_ORD_ID|2499|hsp_num:0 2880 Z1_02866 HTH-type transcriptional regulator BenM Loose 650 62.4 adeL 31.36 3000620 protein homolog model n/a n/a fluoroquinolone antibiotic; tetracycline antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MNIELRHLRYFIAVAEELHFGKAAERLNISQPPLSQQIQALESEIGARLLERTNRSVSLTPAGQMFLKGSYQIMAQVKAVATRASRMEKGELGEISIGFTSTTPFMHLVTLSLRQFRENYPEVGIHMHQMNTKQQISPLLTGHIDLGIMRNTVLPDNLHHQLLFREPFILAVYEGHPLLEYKETGVNIQDIGQYPFVFFERDVGTALYDEIIQLLSLAGITPTIAQEAGEAMTILGLVAAGLGISIVTKSFTRMKVDGVHYLHFANSNAFSEVWLVSHNKRTIPAAANRLTQLLLKNILEDQKS MRVFNKVVETNSFSLAADSLGLPRASVTTTIQALEKHLQVRLLNRTTRKISLTPDGAVYYDRTARILADVADIESSFHDAERGPRGQLRIDVPVSIGRLILIPRLRDFHARYPDIDLVIGLNDRPVDLVGEAVDCAIRVGELKDSSLIARRIGTFQCATAASPIYLEKYGEPTSIEDLQKNHKAIHFFSSRTGRNFDWDFVVDDLIKSVSVRGRVSVNDGDAYIDLALQGFGIIQGPRYMLTNHLESGLLKEVLPQWTPAPMPISAVYLQNRHLSLKVKVFVDWVAELFAGCPLLGGTALPFDQKCEFACDKETGHEYTIRTLVEQHNIAEAYTLKT 90.21 gnl|BL_ORD_ID|2323|hsp_num:0 2654 Z1_02874 hypothetical protein Loose 300 51.6 AAC(2')-Ia 29.79 3002523 protein homolog model n/a n/a aminoglycoside antibiotic antibiotic inactivation AAC(2') MRIECYSWSDVSEQILEQAIALQNSAFEDMKGNFYQVDIPYKLVLAIDDNQVIGHVAVYLRDVYLDSFPETIGILSCVVVAHKYRGKGVAASLIKRAHAILKEHSVNFSILFAVSHAYYLSSGYIPMKNLTRFIENNEKKEFIYDGGMVCELGSQNWNVNILELNGEVV MGIEYRSLHTSQLTLSEKEALYDLLIEGFEGDFSHDDFAHTLGGMHVMAFDQQKLVGHVAIIQRHMALDNTPISVGYVEAMVVEQSYRRQGIGRQLMLQTNKIIASCYQLGLLSASDDGQKLYHSVGWQIWKGKLFELKQGSYIRSIEEEGGVMGWKADGEVDFTASLYCDFRGGDQW 94.94 gnl|BL_ORD_ID|1638|hsp_num:0 1781 Z1_02879 Xylose operon regulatory protein Loose 450 45.8 gadX 29.33 3000508 protein homolog model n/a n/a macrolide antibiotic; fluoroquinolone antibiotic; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MKKDKYFRIVLLFNANKVYDRQVVEGVGEYLQASQCHWDVFIEEDFRTRLDNINHWVCDGIIADFDDPIITQHLSQSPLSVIGVGGSYHQAKDYPSVPYIATDNYQLIHQAFLHLKQKGLKHFAFYGLPAKNYPHWSNEREYAFRQLVTREKYPGIIYNGMDITQENWQHAQNRLSDWIQTLPPQTGIIAVTDARARHLLQVCDNLNINVPEEISIIGIDDEDMTRYLSRIALSSVVQGSRQMGYLAAKLLHQILEGHLTEQLPRILVPPVKIIERRSTDFHSFSDPTVVQAMHYIYYNACKGIKTEQVLDAVNMSRSNLEQRFKKELGKTIHAVIYEEKLKRAKNLLATTTLSIQEISLMCGYPSLQYFYSIFKKEFGMTPKDFRDEN MQSLHGNCLIAYARHKYILTMVNGEYRYFNGGDLVFADASQIRVDKCVENFVFVSRDTLSLFLPMLKEEALNLHAHKKVSSLLVHHCSRDIPVFQEVAQLSQNKNLRYAEMLRKRALIFALLSVFLEDEHFIPLLLNVLQPNMRTRVCTVINNNIAHEWTLARIASELLMSPSLLKKKLREEETSYSQLLTECRMQRALQLIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTEYQERSAQRLSNRDSAASIVAQGNFYGTDRSAEGIRL 141.97 gnl|BL_ORD_ID|79|hsp_num:0 91 Z1_02881 Malate-2H(+)/Na(+)-lactate antiporter Loose 710 49.7 tet(35) 30.6 3000481 protein homolog model n/a n/a tetracycline antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MKTQTINNPRTPTLLESLFPIFTMVVLLGGGYAAFDLPPEPLMVLSTVVAALLVKRLGYRYDEILTAISQKIAKTMPALLILISVGLLIGTWMVGGTIPLMIYYGLKMISPEMLYVTALLVTSLVSVCTGTSWGSAGTIGVAFMGVAVGMEANLAATAGAVVAGAYFGDKLSPLSGDTNLAAMAARIDLYQHICHLLYTTLPSLILTAIIMIVYGMNGDLAGQGEPEKVTLITNGLENIYHFNLILLIPVLVILYGSVTKKPTIPVMLASAAIAMLNAYLIQGFGLHDIVKSAVDGFNVSMIQGKEVPELLGNLLNRGGMNSMMSTLLICFCALSFAGTLSLSGALEVIVHALLKMVHSTGSMILATIACGLTMIGVTCNGQISILIPIEMLRGAYIERGLHPKNLARTVEDSATIFEPILPWTAAGAYMAGTLGVATLSYLPWAVLCWSGIFFAMLWGFTGFGIAKLTPEEQEEMTAELGSHSELQLDTK MCVIMPASSWGAYIITIIGGILVSHGITEYSALGAYVRLIPMNFYAVFALLMVFAVAWFGLDIGKMREHEIAASQGRGFDKDKENDSQEAHDLNEELDIRESEKGKVSDLILPIVTLIVATIASMLYTGGQALAADGKEFVLLGAFENTDVGTSLIYGSLLGLAVALFTVIKQGLPMVEIARTLWIGAKSMFGAILILVFAWTIGSVIGDMKTGSYLSTMAQGNINPHWLPVILFLLSGLMAFSTGTSWGTFGIMLPIAGDMAGATDVALMLPMLSAVLAGAVFGDHCSPISDTTILSSTGARCNHIDHVSTQLPYALSVAFVSCIGFITLGMTASIAFSFIAASITFVIVCAILSWLSKSKMASCQNA 133.06 gnl|BL_ORD_ID|1930|hsp_num:0 1969 Z1_02889 Outer membrane protein OprJ Loose 850 89.4 OprJ 23.66 3000802 protein homolog model n/a n/a macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; cephalosporin; penam; tetracycline antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MIKSAINHKKYILSSWLSLLLVGCIDTSDYGKYSAQQPMPYNNTNYMAASEQYLATPQQEQTTKTSYGLAELIDLGQQNNPETRIAWLLAKKSATDIGMVESTYLPIITATALAGYQRGKVDLPANPIVDDIKTSNSAFIPALTFRWLIFDFGKRGALADAAKHASLATNLNFNLMHQKIIHDVSVAYFSYGAALKKVTLTQEALQRSKDILYAIEQKRARGLATVLDVALAKQQVAQVELQHVLAKGHEKDQYQLLLSAIGVSPFEKIKVNYDNDARLPDDISPLTHDVIKKALSQRPDILAHYELEQAALKTARSVESDYFPKVYLAGALAGGSGHFDVQGLPEISQRTSSSNILIGVSIPLYEGGMRQSRMSNAQSDIQLAQENLRKSQDTAIKEISLSENALRSALEANKAAKNLVDTAQLSYTASVDFFNNGLGTVTEINTAEIALLNAQLSHIDAYTGSLIAAVDLAFALGDIDQGLSNIHLDK MRKPAFGVSALLIALTLGACSMAPTYERPAAPVADSWSGAAAQRQGAAIDTLDWKSFIVDAELRRLVDMALDNIRSLRQTLLDIEAARAQYRIQRADRVPGLNAAATGNRQRQPADLSAGNRSEVASSYQVGLALPEYELDLFGRVKSLTDAALQQYLASEEAARAARIALVAEVSQAYLSYDGALRRLALTRQTLVSREYSFALIDQRRAAGAATALDYQEALGLVEQARAEQERNLRQKQQAFNALVLLLGSDDAAQAIPRSPGQRPKLLQDIAPGTPSELIERRPDILAAEHRLRARNADIGAARAAFFPRISLTGSFGTSSAEMSGLFDGGSRSCSFLPTLTLPIFDGGRNRANLSLAEARKDSAVAAYEGTIQTAFREVADALAASDTLRREEKALRALANSSNEALKLAKARYESGVDNHLRYLDAQRSSFLNEIAFIDGSTQRQIALVDLFRALGGGWDEGRSLVVHRGGRS 102.30 gnl|BL_ORD_ID|746|hsp_num:0 704 Z1_02890 hypothetical protein Loose 1300 141.4 mdtO 39.25 3003549 protein homolog model n/a n/a nucleoside antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MTVKSSLIAKQVKQDLLPFDYRFATTWRIALLCALMAVIAMVYEIPESAISCYLIIYLIKADAVQNILLSLGVIILCSIVVGVALVLFNLTIQNIILRFFFMAFFSAIFMYLASASSLGDIGNLVALVIAFLMTLIEDIPFGDAATRGLLYALLMAVSPMLLVIVFNYFFGISPRKLLLNKISTRFMAAHDFFLGKKTNQITLSEILGTQAECQRYLMVMKILYLLGKEDIQWLENMVDNSYAILVMSITMDDNTSTSLRFMLAKRCKYIADCFANHSLDNIKDSVQRLQPINRIALLAKFNTILLTKRTTKPIKKATPFFVSDAFSNPNHKYFAIKTTLAAILCYLFYDYFKWQGIHTAMITCYVVALTSVGETVHKLTLRIIGCLIGALIGMISLLYIIPNISDIFQLMVLIFFCLLPAAWVAAGNERISYAGVQVGLAFLLTTLHGFKPSFDMDVVSDRILGILLGNIVMYVIFTRVWPASIVNTIYKQLATILDDYTKLRCSTNKSECLDLVASINETIAQSKDNIDLLLFERKDKERNKVFTLFFKQSLSKISYISRHSYADRFIFDDNGEYSDTLPLSPDDFKKNVLTEEIKMLPINEREQVFKQLIRENR MSALNSLPLPVVRLLAFFHEELSERRPGRVPQTVQLWVGCLLVILISMTFEIPFVALSLAVLFYGIQSNAFYTKFVAILFVVATVLEIGSLFLIYKWSYGEPLIRLIIAGPILMGCMFLMRTHRLGLVFFAVAIVAIYGQTFPAMLDYPEVVVRLTLWCIVVGLYPTLLMTLIGVLWFPSRAISQMHQALNDRLDDAISHLTDSLAPLPETRIEREALALQKLNVFCLADDANWRTQNAWWQSCVATVTYIYSTLNRYDPTSFADSQAIIEFRQKLASEINKLQHAVAEGQCWQSDWRISESEAMAARECNLENICQTLLQLGQMDPNTPPTPAAKPPSMAADAFTNPDYMRYAVKTLLACLICYTFYSGVDWEGIHTCMLTCVIVANPNVGSSYQKMVLRFGGAFCGAILALLFTLLVMPWLDNIVELLFVLAPIFLLGAWIATSSERSSYIGTQMVVTFALATLENVFGPVYDLVEIRDRALGIIIGTVVSAVIYTFVWPESEARTLPQKLAGTLGMLSKVMRIPRQQEVTALRTYLQIRIGLHAAFNACEEMCQRVALERQLDSEERALLIERSQTVIRQGRDLLHAWDATWNSAQALDNALQPDRAGQFADALEKYAAGLATALSRSPQITLEETPASQAILPTLLKQEQHVCQLFARLPDWTAPALTPATEQAQGATQ 90.34 gnl|BL_ORD_ID|1896|hsp_num:0 2056 Z1_02891 Multidrug resistance protein MdtN Loose 600 184.5 mdtN 34.25 3003548 protein homolog model n/a n/a nucleoside antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MDKKIKKSLARVITIIVFLITLILLWQSIHISALNPLSEDAIIDANKINISASVPGRIAAVYVKENSKVKKGDLLFTLDPTMYALRVEQAKEQLQIAQATLSNKQRIIIAETSNSEVAQEQIKRAQVNLSLATQSLNRLEPLLAKGFVTAQQVDDARTLKHDAEVTLKQAQKQNVASEALINNTDSEEALVKSLKTSLAMAEWELSNTEVRAPSNGYIAGVVLSPGEFILSGQSVFTLIDSDTWFASAYFKETDLNNIKIGSCVVIYSMIDNQHPIKGKVEGISRGVMSTDLINIPRDLPYVPKSLNWVRVEQRFPVKVIITEPPEALMRIGATATVNIVPNDDDC MESTPKKAPRSKFPALLVVALALVALVFVIWRVDSAPSTNDAYASADTIDVVPEVSGRIVELAVTDNQAVKQGDLLFRIDPRPYEANLAKAEASLAALDKQIMLTQRSVDAQQFGADSVNATVEKARAAAKQATDTLRRTEPLLKEGFVSAEDVDRARTAQRAAEADLNAVLLQAQSAASAVSGVDALVAQRAAVEADIALTKLHLEMATVRAPFDGRVISLKTSVGQFASAMRPIFTLIDTRHWYVIANFRETDLKNIRSGTPATIRLMSDSGKTFEGKVDSIGYGVLPDDGGLVLGGLPKVSRSINWVRVAQRFPVKIMVDKPDPEMFRIGASAVANLEPQ 100.87 gnl|BL_ORD_ID|1324|hsp_num:0 1442 Z1_02894 Penicillin-binding protein 4* Loose 700 75.5 DHA-23 22.6 3002154 protein homolog model n/a n/a cephalosporin; cephamycin antibiotic inactivation DHA beta-lactamase MKNIDNHYIENKIRQLLNPILNDEPGAIIMARFDNGLIYQAEKGLADISQKQKIDENSIFNLASVSKQFTAFSILLLAQEGKLSLDESVLTYLPELGDYAKKISLYELIYHTSGLIDYMELAFERGITYQMPLTPAESFADVVRQTKTYYPIGQKFEYNNTGYFLLSQIIERVSQKPFSVFAEEKIFTPLKMNNTFIVEEYPTINPIVSGYAKDKQGNYQLSESPWTQTGDGAIHSSTSDLMKWGENFRTAKVGGSEVIRKMTQAFSPLTREGQLVIDYEAYGFGLFINNTLGELSFEHGGSWMGTATYFMRLPHLRLTIAVLSNREEYNADVIAIEVAKILIQACKRIG MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSSSKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE 92.35 gnl|BL_ORD_ID|3517|hsp_num:0 4576 Z1_02895 Multidrug resistance protein MdtL Loose 500 100.1 bcr-1 23.91 3003801 protein homolog model n/a n/a bicyclomycin-like antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MIYPLGVDLYLTGLTAIASDLNASEVTLHHAFSIYLMGMVSSMLIAGWCSDNLGRKPVILFGTLIFFFASLSAGLSITEKQFLISRFFQGSGSGFCYVVTFAILRDTLTEQQRAKVLSMINGITCIIPVLAPVLGFIILLYCEWSMMFYLMGAYSLLVFIFCFLGIKETYHKKEIKNKKVNLSVIKPTTDSFFTRYFLSRLLISCLGMAVILTYVNISPIVVMQQMNYSTGEYSILMTSLAMISMTISFLMPKILMKYRYKHILSVGFICFGIGIIFLFIGKKSDMRWFFITFALCGSGFALLFGIIMSQALSPFSQRAGVASSVLGISQLSFSSLYIWVMGWIEVSSINMLVVILFISCIVGTLFLCFPRFTEQKKVKYNV MPASASRIQVGSGERRLLLLLSALVAFGPLSIDMYLPSLPAIAADLGASDAQVQRSISGFLVGFCVGMLFYGPLSDRFGRRPVLLAGIALYLFSSLACALADSAGQLVLLRVLQALGGGAASVLARAMVRDLYPLGEAARMLALMHMVTMLAPLAAPLLGGYLMLWAGWRALFVVLALFAGLCLLAVWRVAESHPPERRGGSLAQAFLAYGRLLGDRRALGYVLCMGLAFAGMFAYISAAPFVFIEHFGVRAERFGWFFGLNILGVMLATWCSARLVRRHGPRPLLRAGSLLACVSGLFLLGYAALGERGGLWALVPGLLCFVSVTGLLGANCIASLLALYPGQAGAASAVAVSGQFGLGCLASLAVGWLALPGVLPMALVMAVCGVGSLLALGLALHGGNR 95.02 gnl|BL_ORD_ID|2340|hsp_num:0 2303 Z1_02899 putative ABC transporter ATP-binding protein YbiT Loose 1300 273.5 optrA 31.61 3003746 protein homolog model n/a n/a oxazolidinone antibiotic; phenicol antibiotic antibiotic target protection Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins MQFGSKPLFENISVKFGGGNRYGLIGANGSGKSTFMKILGGDLAPTSGNVFLDPNERLGKLKQDQFAYEEFTVLDTVIMGHAELWEIKQERERIYSLPEMSEEEGLRVADLEVKFGEMDGYTVESRAGELLLNVGIPLEQHNGPMSEVAPGWKLRVLLAQALFADPDILLLDEPTNNLDIDTIRWLEQTLNERNSTMIIISHDRHFLNMVCTHMADLDYGGLTVHPGNYDEYMLAATQARERLLADNAKKKAQISELQSFVSRFSANASKSRQATSRAKQIEKIQLTEVKASSRQNPFIRFEQEKKLFRNALEVENIAKGYEANTPLFKDVNMMLEVGEKVAILGTNGVGKSTMIKTLVGELTPDNGRVKWSENATIGYYAQDHATDFEVDMTVFDWMSLWMKPEDDEQSVRSVLGRLLFSQDDIKKSVKVLSGGEKGRMLFGKLMMQKPNVLIMDEPTNHLDMESIESLNMALELYQGTLIFVSHDREFVSSLANRIIEITPEKVTNFQGTYDEFLAKKGIDG MSKATFAIASTNAKEDMKMQYKIINGAVYYDGNMVLENIGIEINDNEKIAIVGRNGCGKTTLLKAIIGEIELEEGTGESEFQVIKTGNPYISYLRQMPFEDESISMVDEVRTVFKTLIDMENKMKQLIDKMENQYDDKIINEYSDISERYMALGGLTYQKEYETMIRSMGFTEADYKKPISEFSGGQRTKIAFIKILLTKPDILLLDEPTNHLDIETIQWLESYLRSYKSTLVIISHDRMFLNRIVDKVYEIEWGETKCYKGNYSAFEEQKRENHIKQQKDYDLQQIEIERITRLIERFRYKPTKAKMVQSKIKLLQRMQILNAPDQYDTKTYMSKFQPRISSSRQVLSASELVIGYDTPLAKVNFNLERGQKLGIVGSNGIGKSTLLKTLMGGVAALSGDFKFGYNVEISYFDQQLAQISGDDTLFEIFQSEYPELNDTEVRTALGSFQFSGDDVFRPVSSLSGGEKVRLTLCKLLYKRTNVLILDEPTNHMDIIGKENLENILCSYQGTIIFVSHDRYFTNKIADRLLVFDKDGVEFVQSTYGEYEKKRMNSEKPFNNIKVEQKVEKNNTVKGDRNSIEKEKVKKEKRIEKLEVLINQYDEELERLNKIISEPNNSSDYIVLTEIQKSIDDVKRCQGNYFNEWEQLMRELEVM 80.00 gnl|BL_ORD_ID|2074|hsp_num:0 2263 Z1_02901 HTH-type transcriptional regulator BetI Loose 420 48.5 adeN 40.98 3000559 protein homolog model n/a n/a macrolide antibiotic; fluoroquinolone antibiotic; lincosamide antibiotic; carbapenem; cephalosporin; tetracycline antibiotic; rifamycin antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; penem antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MSLEEKNIDKPRTKPAEVRLEELMNAAETLFLEKGFDATTVSDIVKQAGVAKGTYYHYFTAKTDILDALRTRYMDWYIDKIEQAMASCQIQDFRAKLKQWCETSVIAYVEKQELHDMLFHQVFHQSGNIHENRALQQLQKILMGGTENKTWQVLQPELTCTLIYHGMHAAVDNLEHSTEYTSQTLGALLYRQFTQLLN MHDPVLESHHLVCEKPQTRRGIERRLALLLSATELFLEKGYDAVSLDDIVNHAGGSKTSIYKYFGNKDGLFTAICDYRREMFFKDICIAFQPEQTSLKDYLIQTLIRFYKPFIQPEHIAFLRLVIEQTQCNATLSQYLYEKCALDVQNTIAQALLISHQSGEITCTSPDHSSLMYFGILRDIEWRMIMGMPLPPNETEVIDYINYCVDIFLKGHHKV 91.24 gnl|BL_ORD_ID|1740|hsp_num:0 1880 Z1_02902 Multidrug resistance protein Stp Loose 1050 184.5 facT 32.79 3001313 protein homolog model n/a n/a elfamycin antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MSYTKRLSLICAICLGTFMATLDISIVNVALPTIQNDINANMATLQWIVDAYALCLSACILSSGPLSDRFGRKKVWLWGGIIFTLGSLICAIAQQHEILILGRIIQGIAAAALIPGALSLITHAFPVDIERIRIIGIWSSVSALSLIIGPILGGALVHASGWASIFLINIPIGAITVLLGWYGLSESADPEDVALDPLGQLTSILGLGLLTYGFIEAGSVGWSDYRTVFALIVGLIFITLFVIVEKRIERPLLPLSLFKDRSFFQYNLSSFTLGFATYSNVFFIAFFLQKAQGWSALETGLRMAPEFIAMALFSMLFGRFSRYISVRKLMIFGFLLIAISSCLLATLATNSPYAITGSYLFILGAGMGLATPAIGVLVMKSVAPSRSGMASATMNALRQTGMTMGIALLGTLMIQQAINYMMIQSQALGIVAEPINIITLVTENKTASLDNQLVALLPEAFNSGFAYAMLTAGLSCFITLFIMLFPCKEKQGALSQQIAD MNKAGQAEKPAAAGPPATPETPEPDPKRWLALTVLLVATFMDLLDANIITVAIPSIQRDLGASTFAIQAMTAGYTLSFAVLLITGGRLGDIFGRKRMFLVGVGGFVLASAMCAAAPSTDLLVVARALQGLTAAVMVPQVLALIHVSFAPQEIGRVVSLYASMVGLAIVSGPLIGGALISWNPLDLGWRSIFVVNLPVGVLALVGAAKWMRESSSPHAKRLDIAGMLLIVLGLLLLMVPLTLGRELDWPVWSIVSLVAAAPVLVLFVVYERHKTAKDGSPLVTLSLFKVRAFGAGIGVQLLFSAIPAGFFLSWTLYLQAGLGWSALHTGLTAIPFSLCVPIVGGLAVRRLSPLYGRYCLLAGAVLMLAGILSYAWAADRFGTDITSWHAIPSMLLIGSGMGMLMPPLTALVLREVQPQEAGAASGIINATGQLGAALGVAVIGSLFFAALAGNAGPQAERVAPTVQSVSPRQASDLRDCATEALGQDDLAKVPDICSTLVQGADDGTRDTINGALGEIRAKTFVSTYSETLYWAAGGLVPVTALVLLLPHHRVRREEPAQ 89.45 gnl|BL_ORD_ID|1348|hsp_num:0 1469 Z1_02903 HTH-type transcriptional regulator DmlR Loose 650 102.4 adeL 27.49 3000620 protein homolog model n/a n/a fluoroquinolone antibiotic; tetracycline antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MSIDLNLLRIFSAVAEQAQFASAARSLSMPTSNVSRAIKQLEQQLNCRLIDRTTRKMRLTEQGKILYQQAKKTLYELDNVVEHITSDGPLTGTFRLTIPSEYGSELLADILADFAALHPNLTIQCDTQLMPRNVIEDDIDLLLTFHRGQLADSSYHSRLIKSWRSIVVASESLLTKTGIPTDIEQLSQLPCISSLSALEGQPWIFIDKEQNPVKVTINSCYRVNSAILAKAAVLKGLGFAILAEHCCLDAIKAGKLRAISFPQQPASISLVAIYASRRSLSRNIEHFLAFLTQRL MRVFNKVVETNSFSLAADSLGLPRASVTTTIQALEKHLQVRLLNRTTRKISLTPDGAVYYDRTARILADVADIESSFHDAERGPRGQLRIDVPVSIGRLILIPRLRDFHARYPDIDLVIGLNDRPVDLVGEAVDCAIRVGELKDSSLIARRIGTFQCATAASPIYLEKYGEPTSIEDLQKNHKAIHFFSSRTGRNFDWDFVVDDLIKSVSVRGRVSVNDGDAYIDLALQGFGIIQGPRYMLTNHLESGLLKEVLPQWTPAPMPISAVYLQNRHLSLKVKVFVDWVAELFAGCPLLGGTALPFDQKCEFACDKETGHEYTIRTLVEQHNIAEAYTLKT 87.54 gnl|BL_ORD_ID|2323|hsp_num:0 2654 Z1_02906 Na(+), Li(+), K(+)/H(+) antiporter Loose 780 39.3 tet(H) 23.13 3000175 protein homolog model n/a n/a tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MFSKKSRSTTALLFSSLILTIGRGATLPFMAIYLSRQYKLPVDDIGIAMSISLTTGIVFSLAFGMLADKFEKKRYMVFSIITFIIAFSAIPMVNSTILVVIFFSIINCSYLVFSTVLKAYFSETLSISAKPKIFSLNYTFINIGWTVGPPIGTLLLMYGTQLPFWLAAISASIPLFMIQCFVQRSVVDHSTEENSVKWDPKIMLKDKALGWFVLSTFFGTLTFGTFASCISQYLLVVYDAKLAESAIAVILPVNAAIVVSLQYIVGKQVVAERLRKLMTLGTLFFILGLAGFMLAGDNLIFWAMAIAIFTFGELIYAPGEYMMIDNIAPLGMKASYFSAQSLGWLGAALNPLASGYILTTLPPISLFAILMGIAVLAWLCMLQGMNYSEKRIAA MNKSIIIILLITVLDAIGIGLIMPVLPTLLNEFVSENSLATHYGVLLALYATMQVIFAPILGRLSDKYGRKPILLFSLLGAALDYLLMAFSTTLWMLYIGRIIAGITGATGAVCASAMSDVTPAKNRTRYFGFLGGAFGVGLIIGPMLGGLLGDISAHMPFIFAAISHSILLILSLLFFRETQKREALVANRTPENQTASNTVTVFFKKSLYFWLATYFIIQLIGQIPATIWVLFTQYRFDWNTTSIGMSLAVLGVLHIFFQAIVAGKLAQKWGEKTTIMISMSIDMMGCLLLAWIGHVWVILPALICLAAGGMGQPALQGYLSKSVDDNAQGKLQGTLVSLTNITGIIGPLLFAFIYSYSVAYWDGLLWLMGAILYAMLLITAYFHQRKTTPKAVISTP 98.50 gnl|BL_ORD_ID|1039|hsp_num:0 1027 Z1_02913 Virulence protein Loose 250 38.5 FosM3 24.79 3007099 protein homolog model n/a n/a phosphonic acid antibiotic antibiotic inactivation fosfomycin thiol transferase MKITHLDHLVLTVADIEASCHFYHNVLGFEIITFKQGRKALAFGHQKINLHQLGKEFLPKAAKPTAGSADLCFITETPLLDVIEHINQQGINIEEGPVPRTGATGPIMSVYLRDPDNNLLEIANIIE MVKIKGLNHLLFSVSNLEESIEFYRNVFDAKLLVKGRSTAYFDVNGIWLALNEEKDIPRNEINQSYTHIAFSIEETEFDGIYHKLKELNVNILSGRPRDQKDKKSIYFTDLDGHKFEFHTGTLQDRLDYYKEEKKHMEFYNE 89.44 gnl|BL_ORD_ID|4785|hsp_num:0 5774 Z1_02914 D-alanine--D-alanine ligase A Strict 250 264.2 vanG 39.09 3002909 protein homolog model n/a n/a glycopeptide antibiotic antibiotic target alteration glycopeptide resistance gene cluster; Van ligase MSKLRVAIIFGGKSTEHQVSLQSAKNIINELDRTKFDLCLIGINEQGQWHEYAEDNYLINSDNPSTISLSQPLRPVAIIPGSTRQQFISLTDGQPLAQIDVVFPIVHGAYGEDGTLQGLLHMIDMPYVGPNIMSSAACMDKDITKRLLDDAGLAVAPFITLMAHQLNDISYNEVVEQLGLPLFIKPANLGSSVGISKVNNEAEFNAALSMAFEYDLKVIIESAIVGREIECAVLGNEEPEVSPCGEIVLNDAFYAYNTKYIDDDGAKVVVPADLDNAISLHIRQTALKAYQVLNCLGMSRVDVFLTEDNQVIINEINTLPGFTNISMYPKLWQSTGLDYQSLITKLIELALEHHKKTAVLKTKCEL MQNKKIAVIFGGNSTEYEVSLQSASAVFENINTNKFDIIPIGITRSGEWYHYTGEKEKILNNTWFEDSKNLCPVVVSQNRSVKGFLEIASDKYRIIKVDLVFPVLHGKNGEDGTLQGIFELAGIPVVGCDTLSSALCMDKDRAHKLVSLAGISVPKSVTFKRFNEEAAMKEIEANLTYPLFIKPVRAGSSFGITKVIEKQELDAAIELAFEHDTEVIVEETINGFEVGCAVLGIDELIVGRVDEIELSSGFFDYTEKYTLKSSKIYMPARIDAEAEKRIQEAAVTIYKALGCSGFSRVDMFYTPSGEIVFNEVNTIPGFTSHSRYPNMMKGIGLSFSQMLDKLIGLYVE 104.87 gnl|BL_ORD_ID|1072|hsp_num:0 1157 Z1_02915 putative ABC transporter ATP-binding protein YheS Loose 1300 204.1 optrA 29.04 3003746 protein homolog model n/a n/a oxazolidinone antibiotic; phenicol antibiotic antibiotic target protection Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins MSTLLSTQNLSFHNNHGILLSNISLALTKGEKIGLIGYNGCGKSTLLKLLSHQLIPTDGSITIANQVIMAYVEQQLPSELQSMRLIDAVLHKLPEELRISESWRSELLLSEMGFKANEINLLVSQLSGGQHTRLLLARALILQPDLLLLDEPSNHLDLPTILWLETFLTQWRGSFILVSHDNRLLDKVTNCTWIIRDKTLSVFRLPCSQARQEQEAQDISAQHRCDAQQKEIDRIAQSAKQLAIWGKVYDNESLSRKAKQMEKQIVRLKDEQVDVTEGNQWTLQLSGTILRADRLLELHQLSVIPAPDAPILYTIDNQRIKSGDRVAIVGANGTGKSSLLKMIWSSFHGSTTSTENMIRLHPRVELGYYDQSLAQLNDNDTLADALKPFAPLLDEQRKMALINAGFVYSRHNQQVKSLSGGERARLLFIGLSLAKYSLLMLDEPTNHLDMEGKQALAEQIQRFSGGILLVSHDRELIEKSCNRFWYIHNGILSEHHDIETIYQLISQQDMSSVSNEQNGHHAPSVEIVKHHNEDELLMKLIALEDKLNADLARKSAHQKPILQAQWQAEIEILKQQLDLA MSKATFAIASTNAKEDMKMQYKIINGAVYYDGNMVLENIGIEINDNEKIAIVGRNGCGKTTLLKAIIGEIELEEGTGESEFQVIKTGNPYISYLRQMPFEDESISMVDEVRTVFKTLIDMENKMKQLIDKMENQYDDKIINEYSDISERYMALGGLTYQKEYETMIRSMGFTEADYKKPISEFSGGQRTKIAFIKILLTKPDILLLDEPTNHLDIETIQWLESYLRSYKSTLVIISHDRMFLNRIVDKVYEIEWGETKCYKGNYSAFEEQKRENHIKQQKDYDLQQIEIERITRLIERFRYKPTKAKMVQSKIKLLQRMQILNAPDQYDTKTYMSKFQPRISSSRQVLSASELVIGYDTPLAKVNFNLERGQKLGIVGSNGIGKSTLLKTLMGGVAALSGDFKFGYNVEISYFDQQLAQISGDDTLFEIFQSEYPELNDTEVRTALGSFQFSGDDVFRPVSSLSGGEKVRLTLCKLLYKRTNVLILDEPTNHMDIIGKENLENILCSYQGTIIFVSHDRYFTNKIADRLLVFDKDGVEFVQSTYGEYEKKRMNSEKPFNNIKVEQKVEKNNTVKGDRNSIEKEKVKKEKRIEKLEVLINQYDEELERLNKIISEPNNSSDYIVLTEIQKSIDDVKRCQGNYFNEWEQLMRELEVM 88.55 gnl|BL_ORD_ID|2074|hsp_num:0 2263 Z1_02940 Sensor protein KdpD Loose 850 96.7 baeS 29.69 3000829 protein homolog model n/a n/a aminoglycoside antibiotic; aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MEQAPQWQRPSPDDLLALTRAPHRGRLKIFFGACAGVGKTYAMLQEAQRLHQQGIDVLAGVVETHQRQETAQQLEGLPLLPPLKLHYRGRKLSAFNLDAALARHPAVILMDELAFSNPHKCRHPKRWQDVEELLDAGIDVLTTINVQHIESLNDIVGSITGIRVQETIPDYIFDNADEVVMVDLPPDDLQQRLNEGKVYLAGQAERAIEHFFRKGNLIALRELALRRMADRVDSQVKEFRDSQGGTPVWHTTDSLMVCLGAHGRNDKLVRTAARYAAAFGCQWHAIYVETPKLHQIGEHKRRAILHSLKLAQHLGARTAILSDNQAEKAVIRYAREHNLGKVIIGQRPYQKWQWLKRWVRMRFAERLARYAPDLHVISVALNEEEPRYKTKTFVPQNDKWRQNLKGYLTAIGLCLAITLFSRTFLLALDKANLVTLYLLGVVLIALFFGRRPSIFAALINVISFDLFFVQPHFSLAVLDMQYLVTFSVMLIVGLVVGNLTAGMRYQTRVARYREQRTRHLFEMTRELSRALTLQEVVRTSYHFLSSAFDAKVCLLMPNHHGELTPYNAEGMGQLPIDSGIARWCWDKDQIAGAGTDTLPSVPYQLHPISASQQVLAILAIEPNNLRQVLIPEQQQLLQTFNGLIANALERLQQAEMAEQSRINIEREQLRNALLAALSHDLKTPLTVLFGQSEILLLDLSAEGSAHTEQVSQIRQQILTTSRLVNNLLDMARIQSGGIQVNLQWNLLQEIAGSAVRSLSYLLDKHPLQIDISADLLLYCDSLLIERVLTNLLENAVKYTASQTKLGIKATVEEDQIHVEVWDEGAGIPTEQLQFIFNKFSRAVKESAIPGVGLGLAICSAIIHLHEGKIWAENNKKGGASFHFVLPLKSLPNIDEIEIKQ MKFWRPGITGKLFLAIFATCIVLLISMHWAVRISFERGFIDYIKHGNEQRLQLLSDALGEQYAQHGNWRFLRNNDRFVFQILRSFEHDNSEDKPGPGMPPHGWRTQFWVVDQNNKVLVGPRAPIPPDGTRRPILVNGAEVGAVIASPVERLTRNTDINFDKQQRQTSWLIVALATLLAALATFLLARGLLAPVKRLVDGTHKLAAGDFTTRVTPTSEDELGKLAQDFNQLASTLEKNQQMRRDFMADISHELRTPLAVLRGELEAIQDGVRKFTPETVASLQAEVGTLTKLVDDLHQLSMSDEGALAYQKAPVDLIPLLEVAGGAFRERFASRGLKLQFSLPDSITVFGDRDRLMQLFNNLLENSLRYTDSGGSLQISAGQRDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERDLQREV 192.72 gnl|BL_ORD_ID|916|hsp_num:0 986 Z1_02941 KDP operon transcriptional regulatory protein KdpE Loose 400 300.8 kdpE 63.96 3003841 protein homolog model n/a n/a aminoglycoside antibiotic antibiotic efflux kdpDE MTPYNILIVEDEKEILRFVRLALENEGFRVYDASECQRGLIEAASRKPDLVILDLGLPDKDGLCFIQDFRQWSSTPIIVLSARDSEQDKVDALDAGADDYLTKPFGMSELLARVRASLRRFVKQETETTQFTFGDITIDWVKRIVTRQGVPIHFTPTEFRLLSELVNNSGKVLTQRHLMQHVWGPNFVEHSHYLRIYMGHLRQKIETDPTCPVHLITETGIGYRFMP MTNVLIVEDEQAIRRFLRTALEGDGMRVFEAETLQRGLLEAATRKPDLIILDLGLPDGDGIEFIRDLRQWSAVPVIVLSARSEESDKIAALDAGADDYLSKPFGIGELQARLRVALRRHSATTAPDPLVKFSDVTVDLAARVIHRGEEEVHLTPIEFRLLAVLLNNAGKVLTQRQLLNQVWGPNAVEHSHYLRIYMGHLRQKLEQDPARPRHFITETGIGYRFML 100.89 gnl|BL_ORD_ID|2108|hsp_num:0 2331 Z1_02943 Ribosome-associated ATPase Loose 570 152.1 bcrA 32.6 3002987 protein homolog model n/a n/a peptide antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MRTQSHSHIIELTHVSQHYGDTKALDDVTLTIPAGKMVGLIGPDGVGKSSLISLISGAREIQQGQVIVLNGDMNDVNHRRAVCPKIAYMPQGLGKNLYHTLSVFENVDFFGRLFGQSKQEREERINDLLESTGLAPFKDRPAGKLSGGMKQKLGLCCALIHDPQLLILDEPTTGVDPLSRAQFWELINRIRKRQTNMSVLVATAYMEEAERFDWLVAMDAGKVLATGHAEELKAQTATDELEAAFIELLPEEKRKNHQKVIIPPRDKSDDDIIAIEAKELTMRFGQFVAVDHVSFRIPKGEIFGFLGSNGCGKSTTMKMLTGLLEASEGRAWLFGQEVDPKDIETRKRVGYMSQAFSLYSELTVRQNLELHAKLFHIPEQDIPQRIKEMSERFNLTDVEDMMPDGLPLGIRQRLSLAVAVIHKPEMLILDEPTSGVDPIARDMFWKLMVDLSRRDGVTIFISTHFMNEAARCDRMSLMHAGKVLVTDTPANLVKNSQFDTLEEVFIDYLKKASGETEAPDIEDKQLQLPASSEESAEKALKQRFSLRRLFSYSIREGMELRRDPVRLTLALLGTVILMFIMGYGISMDVENLRFAIMDRDQTGLSQAYSQNLSGSRYFIEKAPITDYNQLERRLRSGDITVAIEIPPNFARDVAKGHKVKIGVWIDGAMPNRAETVRGYIQAMHLTWMLDMAMRQPTNMVDQFSPIDIETRYRYNPDVKSLPAIVPAVIPLLLMMIPAMLSALSVVREKELGSIINLYVTPVTKAEFLLGKQIPYILLGMFNFFMLCALSVFVFGVSFKGSMLTLSLGALLYITIATGMGLLISCFMKSQIAAIFGTSIITLIPATQFSGMIDPVSSLEGIGKWIGHIYPTSHFLTITRGTFSKGLNLFDLPWSFIPLLITIPIVIGLSVFFLKKQEA MSTIIKTTDLTKMYGSQKSVDHLNINVKQGDIYGFLGRNGAGKTTTIRMLLGLIKPTSGQIEIFGENFFKNKKEILRRIGSIVEVPGFYANLTARENLLINAKIIGIHKKNAIDEVLEIVGLQHETKKLVGKFSLGMKQRLGIARALLHYPELLILDEPTNGLDPIGIKEMRRLIHSLAKERNITIFISSHILSEIEQLVDHVGIIHEGKLLEEIPFDHLKKRNRKYLEFQLSDQNKAVVLMEQHFDIHDYEVHQDGIIRVYSHLGQQGKLNKLFVENGIDVLKITMSEDSLEDYFVKLIGGGTIG 300.00 gnl|BL_ORD_ID|316|hsp_num:0 345 Z1_02944 hypothetical protein Loose 730 58.2 farA 25.9 3003961 protein homolog model n/a n/a antibacterial free fatty acids antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MKNQKTNRFFVYGIIIVAIIAAGIFWWKTQAPALPDGFAQSNGRIEATEIDISTKTPGRIDTILVKEGDFVKAGEVLATMDTRTLKEQLHEVQAQLEQAKSSVMTAESALSQRQSEQVAAQAVVRQRIAELDASVKRLNRSRALVKTKAISIQQLDDDIARTEGARAAVEAAKAQVTATIAAIDSAKSGIIQAKTKVDAATATERRIMAELDDSILKAPRNGRVQYRVAEPGEVLGAGGRVLNMVDLSDVYMTFFLPTEAAGKAALGSDVHIILDAAPHIVIPAKTTYVASVAQFTPKTVETDNERLKLMFRVRARISPELLEKHLEYVKTGLPGRAYIRLDNSQPWPTDLEVKLPQ MDTHTDETKLQNTQAKRKRRLTALTLLFALAAAAAGSAFFLWWQHEEETEDAYVAGRVVQVTPQKGGTVRKVLHDDTDAVKKGDVLAVLDDDNDVLAYERAKNELVQAVRQNRRQNAATSQAGAQVALRRADLARAQDDLRRRSALAESGAVSAEELAHARAAVSQAQAAVKAALAEESSARAALGGQVSLREQPAVQTAIGRLKDAWLNLQRTQIRAPADGQVAKRSVQVGQQVAAGAPLMAVVPLSDVWVDANFKETQLRHMKIGQPAELVSDLYGKQIVYRGRVAGFSAGTGSAFSLIPAQNATGNWIKVVQRVPVRIVLNREDVDRHPLRIGLSMTVKVDTSAAGAPVSKTPGAALPEMESTDWSEVDRTVDEILGQSAP 92.97 gnl|BL_ORD_ID|2197|hsp_num:0 2428 Z1_02966 Fumarate and nitrate reduction regulatory protein Loose 400 59.7 CRP 23.6 3000518 protein homolog model n/a n/a macrolide antibiotic; fluoroquinolone antibiotic; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MIPEKRVVRRIQSGGCAIHCQDCSISQLCIPFTLNEHELDQLDNIIERKKPIQKGQTLFKAGDELKSLYAIRSGTIKSYTITEEGDEQITGFHLAGDLVGFDAIINTEHPSFAQALETSMVCEIPFETLDDLSGKMPNLRQQMMRLMSGEIKGDQEMILLLSKKNAEERLAAFIYNLSRRFAQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKSGMLSVKGKYITIEDSEMLSELAGKLPSSTEA MVLGKPQTDPTLEWFLSHCHIHKYPSKSKLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR 120.00 gnl|BL_ORD_ID|804|hsp_num:0 869 Z1_02987 D-lactate dehydrogenase Loose 200 180.3 vanH gene in vanO cluster 33.68 3002948 protein homolog model n/a n/a glycopeptide antibiotic antibiotic target alteration vanH; glycopeptide resistance gene cluster MKIVSYSTKHYDRKHMEWVNQHNGYHYDIEYFDFNLTEQTAKNAVGADAVCIFVNDDANRAVLQELASLNIRILALRCAGFNNVDLKAAAELGITVVRVPAYSPEAIAEHTVGMMLSLNRRIHRAYQRTRDANFSLEGLTGFNMHNRTAGIIGTGKIGLATLRILKGFGMKLLAYDPYPNQAVLDLGAEYVDLATLYANSHVISLHCPLTAENHHLLNESAFSQMKDGVMIINTSRGALIDSAAAINALKQGKIGALGMDVYENERDLFFEDKSNDVIQDDVFRRLSSCHNVLFTGHQAFLTEEALISISETTLHNIKEVAAGITSPNEVKA MSYRDLGLIDSEVIAERRVRALDDSSPSAVPTTGVRVFGCGHDEAVLFREMGTRLGITPSITEEAISETNAELARGNRCISVSHKTQIDNSTLLALSRVGVEYISTRSVGYNHIDVEFAASIGISVGNVDYSPDSVGDYTLMLMLMTVRHAKSIVRRADTHDYRLNDTRGRELRDLTVGVIGTGRIGTAVIDRLQGFGCRVLAHDSGPHASADYVPLDELLRQSDIVTLHTPLTADTHHLLDRQRIDQMKHGAYIVNTGRGPLLDTEALLSALESGRLGGAALDVVEGEEGIFYADCRNRLIENKALVRLQRLPNVLISPHSAYYTDHALNDTVENSLVNCLNFESGRTA 94.86 gnl|BL_ORD_ID|762|hsp_num:0 786 Z1_02989 Transposon Tn10 TetC protein Loose 375 58.9 nalD 37.89 3000819 protein overexpression model n/a n/a macrolide antibiotic; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; cephamycin; penam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; penem antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MKLKSRQQENSEQTRLALLEAGQYLFVNQCYYDVSIDEISRYARVTKGAFYHHFSNKKALLRECYLLQVKHAVQKLDEVPTYDDKWQELTALFSLCVDHIYQCKNELIPLQEVISVLGWKEWEEIDANILIPRIQYCVDILFAEKQICAYSPAIVVNLIYGFITHIAINLKNEASLPKEACSDFKAIFADFLIGVKQASPQRHQHRV MRRTKEDSEKTRTAILLAAEELFLEKGVSHTSLEQIARAAGVTRGAVYWHFQNKAHLFNEMLNQVRLPPEQLTERLSGCDGSDPLRSLYDLCLEAVQSLLTQEKKRRILTILMQRCEFTEELREAQERNNAFVQMFIELCEQLFARDECRVRLHPGMTPRIASRALHALILGLFNDWLRDPRLFDPDTDAEHLLEPMFRGLVRDWGQASSAP 97.64 gnl|BL_ORD_ID|2343|hsp_num:0 1213 Z1_02990 Right origin-binding protein Loose 230 110.2 marA 47.79 3000263 protein homolog model n/a n/a fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics antibiotic efflux; reduced permeability to antibiotic resistance-nodulation-cell division (RND) antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams MSSQFNGLIPSNSLSSFNIEVIKELLLWIEVNLEKPLLLDDVAIKSGYTKWHLQRVFKQATGLTLASYIRGRRLTKAATELRLTKLPVLTIALRYQFDSQQSFTRRFKAVFGVTPSEYRKVDVLCSDNFQPPINFEVTDLPIPNIIELPESFLYVIQYQYFCSIEDIGKLHEDIRHQFWNDFLLYTDKNFTESSVLISYQPNTLRKDKIQIDYEIGLNNLDHFTRPRGFRKKAIAGGRYVRFQFKGTLEEYKQFAIKIYFYTLPALGLCRRLGPDIENYICIETDSDIMELPKTLEIDYYVPIH MSRRNTDAITIHSILDWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEIAQKLKESNEPILYLAERYGFESQQTLTRTFKNYFDVPPHKYRMTNMQGESRFLHPLNHYNS 239.37 gnl|BL_ORD_ID|1775|hsp_num:0 1922 Z1_02992 putative iron export ATP-binding protein FetA Loose 750 88.2 patA 27.72 3000024 protein homolog model n/a n/a fluoroquinolone antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MNNNRALLCLEKIGFQLDSKIILDNVTFSLQPSEFKLITGPSGCGKSTLLKIIASLLSPTSGTLFFDGKDYLTLSPEQYRQQVSYCTQTPMLFGETVYDNLKFPYLLRKIAVDEKKLAKDLDYFNLPNEILNKGINELSGGEKQRISLIRNLQFLPKVLLLDEITSALDEDNKIKVNELIHHYVKEQKIAALWVTHDQNEIKHADDVIHLPSHMNN MLIQKIKTYKWQALASLLMTGLMVASSLLQPRYLQEVLGALLTGKYEAIYSIGAWLIGVAVVGLVAGGLNVVLAAYIAQGVSSDLREDAFRKIQTFSYADIEQFNAGNLVVRMTNDINQIQNVVMMTFQILFRLPLLFIGSFILAVQTLPSLWWVIVLMVVLIFGLTAVMMGMMGPRFAKFQTLLERINAIAKENLRGVRVVKSFVQEKEQFAKFTEVSDELLGQNLYIGYAFSVVEPFMMLVGYGAVFLSIWLVAGMVQSDPSVVGSIASFVNYLSQIIFTIVMVGFLGNSVSRAMISMRRIREILDAEPAMTFKDIPDEELVGSLSFENVTFTYPMDKEPMLKDVSFTIEPGQMVGVVGATGAGKSTLAQLIPRLFDPQDGAIKIGGKDIREVSEGTLRKTVSIVLQRAILFSGTIADNLRQGKGNATLFEMERAANIAQASEFIHRMEKTFESPVEERGTNFSGGQKQRMSIARGIVSNPRILIFDDSTSALDAKSERLVQEALNKDLKGTTTIIIAQKISSVVHADKILVLNQGRLIGQGTHADLVANNAVYREIYETQK 38.30 gnl|BL_ORD_ID|1910|hsp_num:0 2081 Z1_03008 Spermidine export protein MdtI Strict 150 150.6 Klebsiella pneumoniae KpnF 68.81 3004583 protein homolog model n/a n/a macrolide antibiotic; aminoglycoside antibiotic; cephalosporin; tetracycline antibiotic; peptide antibiotic; rifamycin antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MLAQFEWWHGAFLLLAVVLEIVANIFLKMSNGFSRWGLGILSLLCVLGAFSSLAMAVKGIELSVAYALWGAFGIIATIAAGWILFNQRLNYKGWSGIILLLVGMIMIKFA MQQFEWIHAAWLAIAIVLEIIANVFLKFSDGFRRKIYGILSLAAVLGAFSALSQAVKGIDLSVAYALWGGFGIAATIAAGWVLFGQRLNNKGWAGVILLVAGMVLIKLA 100.92 gnl|BL_ORD_ID|2730|hsp_num:0 3286 Z1_03009 Spermidine export protein MdtJ Loose 150 140.2 Klebsiella pneumoniae KpnE 69.91 3004580 protein homolog model n/a n/a macrolide antibiotic; aminoglycoside antibiotic; cephalosporin; tetracycline antibiotic; peptide antibiotic; rifamycin antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MIYWIFLVLAIICEVIGTLSMKYASVSGGYTGMIVMWLMIATSYIFLAIAVKKVALGVAYALWEGIGIVIITTFSVLWFGESLSALKLGGLAMLIAGITLIKSGTKKSAVAKKTTDSVKNIAGKAKQVATVVKGVNKPISSNVKEA MFYWILLALAIIAEITGTLSMKWASVSGGHTGFILMLAMIALSYIFLAFAVKKIALGVAYALWEGIGILLITLFSVLLFDESLSLLKIAGLTTLVIGIVLIKSGTQKKASSQQEVAHAAV 121.67 gnl|BL_ORD_ID|2728|hsp_num:0 3283 Z1_03016 Zinc import ATP-binding protein ZnuC Loose 570 88.6 bcrA 32.85 3002987 protein homolog model n/a n/a peptide antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MSDLIRLKSVGVSFGESVILKDISFNLKAGRILTLLGPNGAGKSTIIRLVLGLLAPSSGKIERQHSLRIGYVPQKLYLDPTMPLTVKRFMTLKPGVKDKDILPALERVNAAKLINAPMQKLSGGESQRVLLARALLNQPQLLVLDEPTQGVDVNGQLALYDLINQLRNELGCAILMVSHDLHLVMAKTDEVLCLNGHICCSGTPDVVSSHPEFIAMFGSRGAEQLGIYRHHHQHNKECHHD MSTIIKTTDLTKMYGSQKSVDHLNINVKQGDIYGFLGRNGAGKTTTIRMLLGLIKPTSGQIEIFGENFFKNKKEILRRIGSIVEVPGFYANLTARENLLINAKIIGIHKKNAIDEVLEIVGLQHETKKLVGKFSLGMKQRLGIARALLHYPELLILDEPTNGLDPIGIKEMRRLIHSLAKERNITIFISSHILSEIEQLVDHVGIIHEGKLLEEIPFDHLKKRNRKYLEFQLSDQNKAVVLMEQHFDIHDYEVHQDGIIRVYSHLGQQGKLNKLFVENGIDVLKITMSEDSLEDYFVKLIGGGTIG 78.76 gnl|BL_ORD_ID|316|hsp_num:0 345 Z1_03034 Vitamin B12 import ATP-binding protein BtuD Loose 1050 110.9 lmrC 27.02 3002881 protein homolog model n/a n/a lincosamide antibiotic antibiotic target protection Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins MTIACQFSQLNIEFNQEALFPPLTHSLACQRNALIGQNGKGKSVLLKLLAQKLLPSSGHIMWRMPFIHIDQLTHLTGNTIADALGIDIFFQAFKRVDNGSASLEDFELLEDKWHLPMTWQNLLHSAQLPVSLETPIPHLSGGEQTRLALCQAFLHDDHFLLLDEPDNHLDHQGQQWLVEQLMHHKSGVLFISHNRHLLSYAENIFELSEKGLQEYGGNYSLYETQKNAQIASIEAANERINSQIKQEKRQQHVTLQKALQRRKQGEKIRNSGSQSLLLLDMQTNRAEKKQSSIAKRHQRVMDDM MADASIVCTNLSFSWPDETPVFDGLSFALGAGRCGLVGPNGAGKSTLLRLAVGELTPTAGSITAQGHVGYLPQSLPLIDGTVDEALEIASIRAALHAIESGDVDEAHFTTVGDHWDIEERTTIVLDRLGLGDVSLDRPLRSLSGGQVLAIGLAAQLLKRPDVLILDEPTNNLDLAARQRLYQVVEEWKGALLVVSHDRELLDRVDTIAELQASELRLYGGNFTAYTEAVELEQENVQRAVRGAEQELRRHKREAQAAQERAQRRASNAKRNKASSGVPRIHAGALQRQAQESAGRAASVHQDRVSQAKAKLDEASQGMREEARLAITLPQTSVPAGRTVLTCHEANVRYGERTLFTGSGVDLGIRGPERIALLGPNGSGKSTLLKLIAGELEPSSGTVTAPTDRVSYLSQRLDLLDLDASVLDNLRRFAPHLQDGEVRYRLAQFLFRGDRVHRTAGWLSGGERLRATLACVLSTDPAPQLLLLDEPTNNLDLNSAAQLENALNAFQGAFVVVSHDQAFLRAIGVSRWLRLADGTLEEIAEADDAWPHRDK 55.27 gnl|BL_ORD_ID|903|hsp_num:0 974 Z1_03035 putative ABC transporter ATP-binding protein Loose 1050 89.4 lmrC 37.32 3002881 protein homolog model n/a n/a lincosamide antibiotic antibiotic target protection Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins MGKLSPLSGEYRLNPNYCYLDQHLTLLDKSLPVAEALYQYQPLMTIEQWRTKLGMLRIRGNKSLFPLETLSGGEQLKATLLALIYSPQPPAVLLLDEPDNYLDLDSKQLLENLLFQYQGTLLLISHDEDFVKQCGITNTLLL MADASIVCTNLSFSWPDETPVFDGLSFALGAGRCGLVGPNGAGKSTLLRLAVGELTPTAGSITAQGHVGYLPQSLPLIDGTVDEALEIASIRAALHAIESGDVDEAHFTTVGDHWDIEERTTIVLDRLGLGDVSLDRPLRSLSGGQVLAIGLAAQLLKRPDVLILDEPTNNLDLAARQRLYQVVEEWKGALLVVSHDRELLDRVDTIAELQASELRLYGGNFTAYTEAVELEQENVQRAVRGAEQELRRHKREAQAAQERAQRRASNAKRNKASSGVPRIHAGALQRQAQESAGRAASVHQDRVSQAKAKLDEASQGMREEARLAITLPQTSVPAGRTVLTCHEANVRYGERTLFTGSGVDLGIRGPERIALLGPNGSGKSTLLKLIAGELEPSSGTVTAPTDRVSYLSQRLDLLDLDASVLDNLRRFAPHLQDGEVRYRLAQFLFRGDRVHRTAGWLSGGERLRATLACVLSTDPAPQLLLLDEPTNNLDLNSAAQLENALNAFQGAFVVVSHDQAFLRAIGVSRWLRLADGTLEEIAEADDAWPHRDK 25.82 gnl|BL_ORD_ID|903|hsp_num:0 974 Z1_03043 Multidrug resistance protein MdtH Loose 750 590.9 mdtH 73.62 3001216 protein homolog model n/a n/a fluoroquinolone antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MALVTQARTLGKYFLLLDNMLVVLGFFVVFPLISIRFVEQLGWAGVIVGFALGLRQLVQQGLGIFGGAIADRFGAKPMIITGMLLRALGFALMALADEPWILWLSCILSALGGTLFDPPRTALVIKLTRPYERGRFYSLLLMQDSAGAVIGALIGSWLLLYDFHLVCWVGAGVFVLAAIFNAWLLPAYRISTTRTPIKEGLKRVILDKRFVQYVLTLTGYFVLSVQVMLMFPIVVNEIAGTPSAVKWMYAIEALLSLTLLYPIARWSEKHFRLEQRLMAGLFLMSISMFPVGITHSLHAIFLIITLFYLGTITAEPARETLSASLADPRARGSYMGFSRLGLAFGGAIGYTGGGWMYDIGKQLELPELPWFLLGTIGFITLYALHRQFNRKKIETAMLTP MSRVSQARNLGKYFLLIDNMLVVLGFFVVFPLISIRFVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEPWLLWFSCLLSGLGGTLFDPPRSALVVKLIRPQQRGRFFSLLMMQDSAGAVIGALLGSWLLQYDFRLVCATGAVLFVLCAAFNAWLLPAWKLSTVRTPVREGMTRVMRDKRFVTYVLTLAGYYMLAVQVMLMLPIMVNDVAGAPSAVKWMYAIEACLSLTLLYPIARWSEKHFRLEHRLMAGLLIMSLSMMPVGMVSGLQQLFTLICLFYIGSIIAEPARETLSASLADARARGSYMGFSRLGLAIGGAIGYIGGGWLFDLGKSAHQPELPWMMLGIIGIFTFLALGWQFSQKRAARRLLERDA 99.50 gnl|BL_ORD_ID|343|hsp_num:0 375 Z1_03048 Glyoxylate/hydroxypyruvate reductase A Loose 200 65.5 vanH gene in vanF cluster 26.46 3002945 protein homolog model n/a n/a glycopeptide antibiotic antibiotic target alteration vanH; glycopeptide resistance gene cluster MNIIFYHPFFDANTWISGMKARLPDAHIRVWEHGDDKPADYAMVWLPPYEMLASRNQLKGIFALGAGVDAILKQEQQKPGTLPAGVPVMRLEDTGMGLQMQEYAIAKVMYYFRRMDDYKRQQSQRLWKQLPAHTYDNFVIGVLGAGALGASVATKLAELGFNVRCWSRSKKQINQVESFYGNDQLSDFVKECQLLINLLPYTPQTHGILNFSLFEQLKPSSYLINLARGAHLVDQDLLEAIDQGYIADASLDVFSQEPLPGMHPFWTHPRISITPHIAAFTIPDIAMDTIVENIQRIEKGETPFGVVDMKSGY MKNIGITIYGCERDEAEVFNELSPRFGVIPAITSSAVSETNAMLAPGNQCISVGHKSEISESILLALKESGVKYISTRSIGCNHIDVKAAESMGIAVGNVAYSPDSVADYTLMLMLMAIRNAKSIVSRAEKYDFRLDTVPGKELREMTVGVLGTGQIGKAVIERLRGFGCHVLAYGHSKEAAANYVSLNELLQKSDILTIHVPLGTDTYHMIGHEQIEAVKQGAFLINTARGGLVDTGALIKALENGRLGGAALDVLEGEEGLFYFDCTQKPIDNQLLLKLHKMPNVIITPHTAYYTGRALYDTVEKTILNCLEFERRETLE 97.20 gnl|BL_ORD_ID|1655|hsp_num:0 1790 Z1_03081 Right origin-binding protein Loose 230 107.8 ramA 45.28 3000823 protein homolog model n/a n/a fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics antibiotic efflux; reduced permeability to antibiotic resistance-nodulation-cell division (RND) antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams MAENVVNDILKWLETQLQRNEGIKIDTIANKSGYSKWHLQRIFKDFKGCTLGEYVRKRRLLEAAKSLQEKDMSILDIALMYGFSSQATFTRIFKKHFNTTPAKFREHGELPDTRRFMSCENS MINQEAEGESSMTISAQIIDTIVEWIDDNLHQPLRIEEIARHAGYSKWHLQRLFMQYKGESLGRYIRERKLLLAARDLRESDARVYDICLRYGFDSQQTFTRIFTRTFNQPPGAYRKENHSRAH 98.39 gnl|BL_ORD_ID|1540|hsp_num:0 1665 Z1_03086 Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase Loose 1000 538.1 ArnT 49.35 3005053 protein homolog model n/a n/a peptide antibiotic antibiotic target alteration pmr phosphoethanolamine transferase MLNNRASKIGAILLALFFVLTYLFPLNSRLLWQPDETRYAEISREMVVSGNWIVPHMLDIRYFEKPIAGYWINNISQLIFGHTNFAVRFGSVISILLSALLIYLLARMMWRNRQVAFVASLIYLSMFLVFSVGTYSVLDPMLALWVTASMVCCFWALKATTVKTRILAWITLGLACGMAFMTKGFLALAIPVIVMIPVTLYQKQFTRMLLYGVLAVLSAALISLPWVLAVAKAEPDYWHYFFWVEHIQRFSGDDAQHSSPFWYYIPIILLGVIPWLGLLPGALTSAWKKRRKRPELFFLLCWFVVPFLFFSIAKGKLPTYMLPFMGPLAMLMAKYGVDCARKFKMKALRINGYINIFIGVAAVVAILIIQLVSSKPIYMPYEWSKWVLAIVAFSLWGIIGYLCSTLNGKHWLWAASCSLGVSLCIGQAIPNSSIDGKLPQEFIRQNIDTLNASKYIVSNSVGVGAGLAWELQRSDIYLYERTGELTYGIEYPDSQHRLLKPESFEQWLENARKEGNVSVVITYKDPKKLAQMPRPEELVTNRRMAILTYEKRK MKSIRYGVSLIALFALYYLLPLNFRLLWQPDETRYAEISREMLATGDWVVPHFLGLRYFEKPIAGYWINSIGQWLFGHNNFGVRFGSVFAITMTALLVAWLAWRIFRDKRVAILSLIIFLTAMLVYAIGTYAVLDPMITLWLALAMCSFWGAVQAHSRSGKILGYVLLGVACGMGVMTKGFLALAVPVVGVLPWVIARKRWREVLTYGWLAVIVCTLVVLPWGLAIAQREPDFWRYFFWVEHIQRFAEKDAQHKAPFWYYIPFLIAGSLPWLALLPGALKRGWLERDEARGALYLLGWVAMPFLFFSIAKGKLPTYILPCFAPLSILMARYALEAAKTGAKALRINGMINLGVGLLGLIAVLVVSPWGFMHKPVWTKIELYKCLLAAIAFAVWALMGWLAMKDSGRRWSLAALCPLGLALLVGFAIPDRVIDSKQPQFLVDIVSESLQPSRYVLTNNVGIAGGLAWELKRSDIIMFDKQGELKYGLDWPDAQGSFVSQAGFADWLAAHRQQGPVSLVLLMDKGESMLDLPLPKPDNAYELGRVVFLQYLPQ 100.36 gnl|BL_ORD_ID|2792|hsp_num:0 3795 Z1_03088 Bifunctional polymyxin resistance protein ArnA Loose 1200 941.4 arnA 67.23 3002985 protein homolog model n/a n/a peptide antibiotic antibiotic target alteration pmr phosphoethanolamine transferase MKAIVFAYHDIGCVGLKALEKAGFDIQAVFTHTDDPNENHFFSSVARVSAEMGLTVFAPENVNHPLWIERIREMKPDVIFSFYYRHMLSDEILNLAPKGAFNLHGSLLPKYRGRAPINWAIVNGETETGVTLHKMTAKADAGDIVAQEKVTIEDTDTSLILHEKVREAAAKLMAHTLPHIASGNYSTTAQDESQATYYGRRCADDGLIDWNADAKTVHNLVRAVTEPYPGAFTFLGERKMIIWRARPVADNQCKRPGTVISTEPLVIACAKGAIEVITGQSENGLYVQGSRLATEMGIVTDVRVGPKATAQVKRRQRVLILGVNGFIGNHLTERLLKDGNYDIYGMDIGSSAIERFIGNPRFHFIEGDVSIHTEWIEYHIKKCDVILPLVAIATPIEYTRNPLRVFELDFEENLKIVRYCVKYNKRIIFPSTSEVYGMCDDKEFDEDNSRLIVGPINKQRWIYSVSKQLLDRVIWAYGAKEGLKFTLFRPFNWMGPRLDNLNSARIGSSRAITQLILNLVEGSPIKLVDGGEQKRCFTDINDGIEALFRIIENRDNKCDGQIINIGNPTNEASIRELAEMLLDCFEKHELRGHFPPFAGFKKIESSSYYGKGYQDVEHRKPSIKNAERLLDWKPTIETRQTVEETLDFFLRGAVEELGNK MTSKAVVFAYHDIGCTGIEALLNAGYEIAAVFTHADDPRENTFYASVARLCAERGIPLHAPEDVNHPLWLERIRQLRPDFLFSFYYRRLLGAELLACAARGAYNLHGSLLPRYRGRAPANWVLVNGETQTGVTLHRMIERADAGPILAQQAVAIDPEDTALSLHGKLRKAAGALLRDSLPLLALGVLPEVEQDESQASHFGRRTPADGLLDWHRPARQLYDLVRAVTQPYPGAFCQVGEQKLIVWSAEVVAGNHGREPGSVLSCDPLRIACGEDSLVLRFGQRGERGLYLAGTQLATELGLVEGARLRGAACSPQRRTRVLILGVNGFIGNHLSERLLRDGRYEVHGMDIGSDAIERLKADPHFHFVEGDIGIHSEWLEYHVKKCDVILPLVAIATPIEYTRNPLRVFELDFEENLRIVRYCVKYGKRVVFPSTSEVYGMCQDPDFDEDRSNLVVGPINKQRWIYSVSKQLLDRVIWAYGQQGLRFTLFRPFNWMGPRLDRLDSARIGSSRAITQLILHLVEGTPIRLVDGGAQKRCFTDVDDGIEALARIIDNRDGRCDGQIVNIGNPDNEASIRQLGEELLRQFEAHPLRAQFPPFAGFREVESRSFYGDGYQDVAHRKPSIDNARRLLDWQPTIELRETIGKTLDFFLHEALREREAQA 99.70 gnl|BL_ORD_ID|1516|hsp_num:0 1643 Z1_03089 Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase Loose 550 474.6 PmrF 71.69 3003578 protein homolog model n/a n/a peptide antibiotic antibiotic target alteration pmr phosphoethanolamine transferase MSTFEKINKVSVVIPVYNEEESLPQLLERTIKSCKQLEQEYELILVDDGSSDNSAKMLEEAANIEDNHVIAIILNRNYGQHSAIMAGFNQADGDLVITLDADLQNPPEEIPRLVATAEEGYDVVGTRRRNRQDSWFRKTASKMINAMITKATGRSMGDYGCMLRAYRRHIIDAMLQCHERSTFIPILANTFARRTIEIEVAHAEREYGDSKYSFLKLINLMYDLLTCLTTAPLRLLSVVGSVIAVAGFLLAVLLIVLRLIFGAIWAADGVFTLFAILFMFIGAQFVAMGLLGEYIGRIYNDVRARPRYFIQKVVGVKKPNKNQEED MFEIHPVKKVSVVIPVYNEQESLPELIRRTTTACESLGKEYEILLIDDGSSDNSAHMLVEASQAENSHIVSILLNRNYGQHSAIMAGFSHVTGDLIITLDADLQNPPEEIPRLVAKADEGYDVVGTVRQNRQDSWFRKTASKMINRLIQRTTGKAMGDYGCMLRAYRRHIVDAMLHCHERSTFIPILANIFARRAIEIPVHHAEREFGESKYSFMRLINLMYDLVTCLTTTPLRMLSLLGSIIAIGGFSIAVLLVILRLTFGPQWAAEGVFMLFAVLFTFIGAQFIGMGLLGEYIGRIYTDVRARPRYFVQQVIRPSSKENE 101.24 gnl|BL_ORD_ID|1940|hsp_num:0 2014 Z1_03091 Vitamin B12 import ATP-binding protein BtuD Loose 800 65.5 msrA 27.84 3000251 protein homolog model n/a n/a macrolide antibiotic; streptogramin antibiotic; streptogramin B antibiotic antibiotic target protection msr-type ABC-F protein MAQLKLYKLAVNKRLYGITEQVNDGERIHLIGANGAGKSTLLMAIAGEVSYVGNIFLNETSMRDYKIAELSRIQSVVRQQSLALPFMPVFHYLSLSYQLSKMDIQELNALLSDFQINKLLSKNIHHLSGGEWQRVRIVATFIQLWSSDDLTGKLMMLDEPTNNLDIVQLTLLDKWLDKFCLQGGSIIMSTHDLNHSYLKADKLWFMLEGKIINSGDSALLLDENLLSTTFNTKIRCNRSANSVIWQVIE MEQYTIKFNQINHKLTDLRSLNIDHLYAYQFEKIALIGGNGTGKTTLLNMIAQKTKPESGTVETNGEIQYFEQLNMDVENDFNTLDGSLMSELHIPMHTTDSMSGGEKAKYKLRNVISNYSPILLLDEPTNHLDKIGKDYLNNILKYYYGTLIIVSHDRALIDQIADTIWDIQEDGTIRVFKGNYTQYQNQYEQEQLEQQRKYEQYISEKQRLSQASKAKRNQAQQMAQASSKQKNKSIAPDRLSASKEKGTVEKAAQKQAKHIEKRMEHLEEVEKPQSYHEFNFPQNKIYDIHNNYPIIAQNLTLVKGSQKLLTQVRFQIPYGKNIALVGANGVGKTTLLEAIYHQIEGIDCSPKVQMAYYRQLAYEDMRDVSLLQYLMDETDSSESFSRAILNNLGLNEALERSCNVLSGGERTKLSLAVLFSTKANMLILDEPTNFLDIKTLEALEMFMNKYPGIILFTSHDTRFVKHVSDKKWELTGQSIHDIT 51.02 gnl|BL_ORD_ID|1108|hsp_num:0 1200 Z1_03101 HTH-type transcriptional activator RhaS Loose 200 54.3 Escherichia coli soxS with mutation conferring antibiotic resistance 33.7 3003511 protein overexpression model n/a n/a fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics antibiotic target alteration; antibiotic efflux; reduced permeability to antibiotic ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams MLLPELHLRCYTQDTVSHQHENIWQIIFGLTGTMEVNFNRQDFLISQQNCLIIPPTIDHAFAGHLNNKNLILELPVTSQWRLNERGGMFALSPAAIGLLAWVHQYPQAPEHHTTLARLLLAQMKVQPSWGDKLDLWLEDKLHMPLTASDIAGALNISISTLQRKVKAELGISIMQYVMQKRLAKSAELLKYTSSTIENIALAVGYDSHSAFSQAFRQYFHKTPSEYRQ MSHQKIIQDLIAWIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGYVSQQTFSRVFRRQFDRTPSDYRHRL 213.08 gnl|BL_ORD_ID|1978|hsp_num:0 2066 Z1_03107 Vitamin B12 import ATP-binding protein BtuD Loose 650 85.9 tetA(58) 25.0 3003980 protein homolog model n/a n/a tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MNDKKVNPTLTVDNATVTYNNGHTAIYDASFSITGGTICALVGINGSGKSTLFKTIMGLVKPSKGTVTLNNQPIQQALKQNMIAYVPQTEEVDWNFPVLVSDVVMMGRYGKMGFFRIPSKQDHEVVEACLERVGLSGLGHRQIGELSGGQKKRVFLARAMAQEGTVLLLDEPFTGVDVKTENAIIELLRNLRKEGHLVLVSTHNLGSVPEFCDHVILINRTVLDSGPTETTFTQKNLEHAFGGVLRHISLSGPDLHDDDDPRSLTVITDDERAAVFYGHHEQHTPAHQSKRKQGD MEHAYKKKIEPKPGDLAVEAYGLIKTFGDNRAVDGVDLNVRTGTIYGVLGPNGAGKTTTIRMLATLLRPDAGSARIFGHDVQAESQIVRQLIGVTGQYASVDESLSATENLIIFSRLLGLGRKEARRKAEELLEEFGLSEAAKRPLKNFSGGMRRRLDLAASLIAQPPLIFLDEPTTGLDPRTRSQMWDTIRRLVNTGSTVLLTTQYLEEADQLADRIAVIDYGRVVAEGTADELKMSVGTSSLHLTVEDSVDMDRACHTVEQVLGVHANVSPEAGKITAPMANAGLVTDLLIELRTAGIGLSEMSVQKPTLDEVFLTITGHGVKEDAAQESYESNDREVARV 86.01 gnl|BL_ORD_ID|2251|hsp_num:0 2517 Z1_03224 Transcriptional regulatory protein PhoP Loose 420 134.0 mtrA 35.62 3000816 protein homolog model n/a n/a macrolide antibiotic; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MRILIIEDNILLRHHLSVQFRDAGHQVDAAQDAKEADHFIAESTPDVAIVDLGLPDEDGISLIRRWRENNITIPIMVLTARESWQEKVTALNAGADDYVTKPFHFEEIVARVQALMRRNMGIASQILTIAPFELDLSRKEFMILGEQIKLTAFEYTILETLMRNQNKVVSKDVLMRQLYPDAEQRESHTIDVLMGRLRKKILQKYDNDVIVTVRGQGYRFDMKA MDTMRQRILVVDDDASLAEMLTIVLRGEGFDTAVIGDGTQALTAVRELRPDLVLLDLMLPGMNGIDVCRVLRADSGVPIVMLTAKTDTVDVVLGLESGADDYIMKPFKPKELVARVRARLRRNDDEPAEMLSIADVEIDVPAHKVTRNGEQISLTPLEFDLLVALARKPRQVFTRDVLLEQVWGYRHPADTRLVNVHVQRLRAKVEKDPENPTVVLTVRGVGYKAGPP 98.25 gnl|BL_ORD_ID|1434|hsp_num:0 1559 Z1_03225 Virulence sensor histidine kinase PhoQ Loose 890 110.5 cpxA 28.36 3000830 protein homolog model n/a n/a aminoglycoside antibiotic; aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MHKKQRSPFSLRTRFLLATSAIILALTLSYGLVAIVGSIVSFDKTTFMLMRSQSNLYYSLAQWKDGQLQIEFPTNLNNNNTSLVVIFDEKGNVLWTPTDLPQVIPNSIAPKWRNKEGLFEISVNVKTTRFMLQQLPQYRAYLKKLNEYSSNDTLTHSVVINHYPAADNMPYLSIAVIDPIPQSLQNVSRVWDWFLYILLANFLLVIPLIWLAAHWSLRPIKSIIEQISALEKGTRDNLDENPPKELKGLVYNLNILLRNERNRYSKYRTSLSDLTHSLKTPLAVLQSTLRALRAGKQMSIEQAEPIMQSQIERISQQVGYYLHRASLHGDHDITTRKLHSLSGLLDNLCSALNKVYQSKGVDITLNVSPEMMWLGEKNDFMEVMGNVLDNACKYCLEFVEINVSHDDNCVIITVDDDGPGVSPEKRELIFQRGTRADTLRPGQGLGLSIAVDIIEQYNGDITITDSPLGGARLIVTFAEQQLTTEIE MIGSLTARIFAIFWLTLALVLMLVLMLPKLDSRQMTELLDSEQRQGLMIEQHVEAELANDPPNDLMWWRRLFRAIDKWAPPGQRLLLVTTEGRVIGAERSEMQIIRNFIGQADNADHPQKKKYGRVELVGPFSVRDGEDNYQLYLIRPASSSQSDFINLLFDRPLLLLIVTMLVSTPLLLWLAWSLAKPARKLKNAADEVAQGNLRQHPELEAGPQEFLAAGASFNQMVTALERMMTSQQRLLSDISHELRTPLTRLQLGTALLRRRSGESKELERIETEAQRLDSMINDLLVMSRNQQKNALVSETIKANQLWSEVLDNAAFEAEQMGKSLTVNFPPGPWPLYGNPNALESALENIVRNALRYSHTKIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAIVETAIQQHRGWVKAEDSPLGGLRLVIWLPLYKRS 106.56 gnl|BL_ORD_ID|132|hsp_num:0 152 Z1_03231 Lipoprotein-releasing system ATP-binding protein LolD Loose 1280 167.9 macB 39.82 3000535 protein homolog model n/a n/a macrolide antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MSNTPLLQCHALCKQYQDGAISTQVLKSVSFAINQGDFMAIVGSSGSGKSTLLHLLGGLDSPTSGEVIFKGQSLNKLTSTAKADLRNTQLGFIYQFHHLLPDFTALENVAMPLMIGGMSAVKAKQKAMSLLDAVGLTARAHHRPSELSGGERQRVAIARALVNDPALVLADEPTGNLDQKNAEGIFELLMKLNKEKKTAFLVVTHDLSLAARFQRQLEMKDGQLESQEAISGVE MSLIECKNINRYFGSGENRVHILKDISLSIEKGDFVAIIGQSGSGKSTLMNILGCLDTAGSGSYRIDGIETAKMQPDELAALRRERFGFIFQRYNLLSSLTARDNVALPAVYMGMGGKERSARADKLLQDLGLASKEGNKPGELSGGQQQRVSIARALMNGGEIIFADEPTGALDTASGKNVMEIIRRLHEAGHTVIMVTHDPGIAANANRVIEIRDGEIISDTSKNPEIPASNVGRIQEKASWSFYYDQFVEAFRMSVQAVLAHKMRSLLTMLGIIIGIASVVSVVALGNGSQKKILEDISSMGTNTISIFPGRGFGDRRSGKIKTLTIDDAKIIAKQSYVASATPMTSSGGTLTYRNTDLTASLYGVGEQYFDVRGLKLETGRLFDENDVKEDAQVVVIDQNVKDKLFADSDPLGKTILFRKRPLTVIGVMKKDENAFGNSDVLMLWSPYTTVMHQITGESHTNSITVKIKDNANTRVAEKGLAELLKARHGTEDFFMNNSDSIRQMVESTTGTMKLLISSIALISLVVGGIGVMNIMLVSVTERTKEIGIRMAIGARRGNILQQFLIEAVLICIIGGLVGVGLSAAVSLVFNHFVTDFPMDISAASVIGAVACSTGIGIAFGFMPANKAAKLNPIDALAQD 36.34 gnl|BL_ORD_ID|447|hsp_num:0 487 Z1_03261 Glutathione transferase FosA Loose 200 171.8 FosA 58.52 3000149 protein homolog model n/a n/a phosphonic acid antibiotic antibiotic inactivation fosfomycin thiol transferase MIMLTDLNHLTLAVNDVKKSFHFYVEVLGFKPLALWDHGAYLQLNTLWLCLSEDTRNITEISDYTHYAFSLSANNFETFKQHLLSHGITSWKENKSEGDSFYFYDPDNHKLEIHVGDLESRLKTCRQYPYSGMQFFDNK MLTGLNHLTLAVADLPASIAFYRDLLGFRLEARWDQGAYLELGSLWLCLSREPQYGGPAADYTHYAFGIAAADFARFAAQLRAHGVREWKQNRSEGDSFYFLDPDGHRLEAHVGDLRSRLAACRQAPYAGMRFAD 102.96 gnl|BL_ORD_ID|1207|hsp_num:0 1222 Z1_03264 HTH-type transcriptional regulator CynR Loose 650 68.6 adeL 31.09 3000620 protein homolog model n/a n/a fluoroquinolone antibiotic; tetracycline antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MDIRVLRYFIEVVQLNGFSRAADALFITQPAISRSIKKLEDELGTVLLIREVDGVKLTDDGAILYEHAKQILAQFNSMNKALNDKDEPLTGALNVGLPPVIASTYFADIIMAFSSRHPNVELKIFELGTKQMEDAMLEGTVETAAVMLPFNDKDFELTIFSEDHLMLLVAQSHPLAKDKKVNFKQLITERFIFFSEDFRINDLVRSACGIYNTEPQIVGRSNHLDLIIAMVKAGVGITLLPNSMCNKYPIDDLVVIPITSPRLSYQLALATNQNSYQSRSCQAWNKLAIEKLMKENI MRVFNKVVETNSFSLAADSLGLPRASVTTTIQALEKHLQVRLLNRTTRKISLTPDGAVYYDRTARILADVADIESSFHDAERGPRGQLRIDVPVSIGRLILIPRLRDFHARYPDIDLVIGLNDRPVDLVGEAVDCAIRVGELKDSSLIARRIGTFQCATAASPIYLEKYGEPTSIEDLQKNHKAIHFFSSRTGRNFDWDFVVDDLIKSVSVRGRVSVNDGDAYIDLALQGFGIIQGPRYMLTNHLESGLLKEVLPQWTPAPMPISAVYLQNRHLSLKVKVFVDWVAELFAGCPLLGGTALPFDQKCEFACDKETGHEYTIRTLVEQHNIAEAYTLKT 88.13 gnl|BL_ORD_ID|2323|hsp_num:0 2654 Z1_03271 HTH-type transcriptional regulator CysL Loose 650 80.5 adeL 25.0 3000620 protein homolog model n/a n/a fluoroquinolone antibiotic; tetracycline antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MRITLRQLEVFTEVLKSGSTTQASQQLALSQSAVSASLTDLENQLGVQLFDRVGKRLVTNEHGRLLYPRALSLLERATEVEQLFQAGNGALRIAASTTIGNYILPQMLGNFHRNYPDIPLEMSIGNTEEVVKSVSEFRVDLGLIEGACQSSELISQKWLLDEMVIFCSPEHPLAKAKTVTLADLQSAPWILRENGSGTRDVLNHLLFASLPGYRIEMELGNSEAIKHAVMYEMGISCLSRRVIQDQIESGSLKEIKVEGLKLQRTLYLVYHRQKHVSDALKKLLSYCNAEHLIDNA MRVFNKVVETNSFSLAADSLGLPRASVTTTIQALEKHLQVRLLNRTTRKISLTPDGAVYYDRTARILADVADIESSFHDAERGPRGQLRIDVPVSIGRLILIPRLRDFHARYPDIDLVIGLNDRPVDLVGEAVDCAIRVGELKDSSLIARRIGTFQCATAASPIYLEKYGEPTSIEDLQKNHKAIHFFSSRTGRNFDWDFVVDDLIKSVSVRGRVSVNDGDAYIDLALQGFGIIQGPRYMLTNHLESGLLKEVLPQWTPAPMPISAVYLQNRHLSLKVKVFVDWVAELFAGCPLLGGTALPFDQKCEFACDKETGHEYTIRTLVEQHNIAEAYTLKT 87.83 gnl|BL_ORD_ID|2323|hsp_num:0 2654 Z1_03282 Bicyclomycin resistance protein Loose 500 228.8 bcr-1 37.6 3003801 protein homolog model n/a n/a bicyclomycin-like antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MQEQRPSYFSLILILGLISMLMPLAIDMYLPSLPTIARDFGVPGGQVQMTLSSYIFGFAIGQMVYGPMADSLGRKPVILGGVIVFALASSACALSDSIDMLIGMRFLHGFAAAAASVVINALMRDMFSRDEFSRSMSFVALVMTIAPLLAPLLGAWVMNWFSWHAIFWSIAIAAIIAAALIALYIPETLPKQHRQRFSLRVTFSQFISLFRARRVLCYILASGFSFAGMFSFLSAGPFVYIELHGIPFDQFGLYFGFNIIFLIVMTSINGRYVRRFGALNMLRFGLTVQFLMGIFLILVVALNLHFYFLVVGVAMYVGGIAMITSNAMAVILEDYPHMAGTVSSLAGTIRFGVGALVGTAIAMLPAKTEWPMVSSMAFCVICAMSFLLLARRYK MPASASRIQVGSGERRLLLLLSALVAFGPLSIDMYLPSLPAIAADLGASDAQVQRSISGFLVGFCVGMLFYGPLSDRFGRRPVLLAGIALYLFSSLACALADSAGQLVLLRVLQALGGGAASVLARAMVRDLYPLGEAARMLALMHMVTMLAPLAAPLLGGYLMLWAGWRALFVVLALFAGLCLLAVWRVAESHPPERRGGSLAQAFLAYGRLLGDRRALGYVLCMGLAFAGMFAYISAAPFVFIEHFGVRAERFGWFFGLNILGVMLATWCSARLVRRHGPRPLLRAGSLLACVSGLFLLGYAALGERGGLWALVPGLLCFVSVTGLLGANCIASLLALYPGQAGAASAVAVSGQFGLGCLASLAVGWLALPGVLPMALVMAVCGVGSLLALGLALHGGNR 98.01 gnl|BL_ORD_ID|2340|hsp_num:0 2303 Z1_03302 Right origin-binding protein Loose 200 105.5 Escherichia coli soxS with mutation conferring antibiotic resistance 42.45 3003511 protein overexpression model n/a n/a fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics antibiotic target alteration; antibiotic efflux; reduced permeability to antibiotic ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams MLQENVVKDIIVWIEQNLDSRLSLDIIAEKSGYTKWHFQRLFKAYTGISLGKYVLARRLSCGAYALRITRSSLLDISLKYHFDSQQTFCRAFKKQFNITPSEYRKKQGWDISELIFPALETVELKAKYEVMTLPSKELIGMAHQYNKNISAWNYDKKKFRKEFWKKFLKEIHTIPTEMYATHRASAGSLDDTTYIYTTAVSKEQLTSSANISTMSKVELPNGKYLVITFEMDNILDSLTGYDDIIYTVYTKVLPKMNLLRRAGPDIERYTLKQSVSYDKLIGHSEQHLQEISYYIPVL MSHQKIIQDLIAWIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGYVSQQTFSRVFRRQFDRTPSDYRHRL 278.50 gnl|BL_ORD_ID|1978|hsp_num:0 2066 Z1_03305 HTH-type transcriptional regulator DmlR Loose 650 156.4 adeL 34.36 3000620 protein homolog model n/a n/a fluoroquinolone antibiotic; tetracycline antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MKATSEEVQVFIAVVESGSFTRAAEKLALANSAVSRTVKKLESKLGVNLLNRTTRQLSLTEEGEHYFHRMQVILQDMKLAEDELINTQKTPQGLLRIDAATPVVLHLLVPFIKQFQQKYPQITLSLVSSETFINLIERKVDIAIRVGNLTDSSLRAKPLLNSYRKIVATPDYLARYGQPKIAEDLLDHTCLTFTEPVSLNTWPIERDNGQLLEAPMGISSNSGETIRQLCLEGNGIACLSDFMVVNDIENGRFIELFPDKLQPIAMPFNAVYYSEKVVSQRIRVFIDSLSEYIAKKVG MRVFNKVVETNSFSLAADSLGLPRASVTTTIQALEKHLQVRLLNRTTRKISLTPDGAVYYDRTARILADVADIESSFHDAERGPRGQLRIDVPVSIGRLILIPRLRDFHARYPDIDLVIGLNDRPVDLVGEAVDCAIRVGELKDSSLIARRIGTFQCATAASPIYLEKYGEPTSIEDLQKNHKAIHFFSSRTGRNFDWDFVVDDLIKSVSVRGRVSVNDGDAYIDLALQGFGIIQGPRYMLTNHLESGLLKEVLPQWTPAPMPISAVYLQNRHLSLKVKVFVDWVAELFAGCPLLGGTALPFDQKCEFACDKETGHEYTIRTLVEQHNIAEAYTLKT 88.43 gnl|BL_ORD_ID|2323|hsp_num:0 2654 Z1_03311 Acetyltransferase Loose 275 39.7 AAC(6')-Ia 35.94 3002545 protein homolog model n/a n/a aminoglycoside antibiotic antibiotic inactivation AAC(6') MMIYCYDDKISEIKIEQLTKLLYRCVLGGASVGYTDAETQVDDMRNYWLSVNHSLSTNTFKLITAVIDGQIVGVVGLELCTKPNGKHRGEICKLLVSPDHRHKGIAQQLMQKAEQIAWERGITLLTLDTITKGMTVSLYRFLGWQVSGEIPEFAQAVDGKFEATTIMFKLKPESNS MNYQIVNIAECSNYQLEAANILTEAFNDLGNNSWPDMTSATKEVKECIESPNLCFGLLINNSLVGWIGLRPMYKETWELHPLVVRPDYQNKGIGKILLKELENRAREQGIIGIALGTDDEYYRTSLSLITITEDNIFDSIKNIKNINKHPYEFYQKNGYYIVGIIPNANGKNKPDIWMWKSLIKE 95.14 gnl|BL_ORD_ID|523|hsp_num:0 574 Z1_03322 Outer membrane protein A Loose 700 513.1 OmpA 71.67 3005044 protein homolog model n/a n/a peptide antibiotic reduced permeability to antibiotic General Bacterial Porin with reduced permeability to peptide antibiotics MKKTAIALAVAVAAFATAAQAAPKDNTWYTGGKLGWSQYQSTGNNWDGVNIGNGSTHKDQIGAGAFAGYQYNQYLGFELGYDWLGRMAYKGSYNNGAFKAQGIQLTTKLSYPVMDDLDVYTRLGGMVWRADSTATINATSAGTQKRFSENDTGVSPVFALGTEYAITPNIATRLEYQWINNIGDKGTLNARPDNGMLSVGVAYRFNQETPAPVVEPAPVVAPAPVVENKTFTLRSDVLFNYNKSSLKAEGQEALNGLYNELANIDPTQGRVVVIGYTDRIGSQNYNLPLSEKRAQSVVDYLVSKGIPANSISAEGRGKENPVTGNTCDNIKARAALIDCLAPDRRVEIEIQGTTEVVVQPGQ MRSFVTSWRILDDNEAQKMKKTAIAIAVALAGFATVAQAAPKDNTWYAGGKLGWSQYHDTGFYGNGFQNNNGPTRNDQLGAGAFGGYQVNPYLGFEMGYDWLGRMAYKGSVDNGAFKAQGVQLTAKLGYPITDDLDIYTRLGGMVWRADSKGNYASTGVSRSEHDTGVSPVFAGGVEWAVTRDIATRLEYQWVNNIGDAGTVGTRPDNGMLSLGVSYRFGQEDAAPVVAPAPAPAPEVATKHFTLKSDVLFNFNKATLKPEGQQALDQLYTQLSNMDPKDGSAVVLGYTDRIGSEAYNQQLSEKRAQSVVDYLVAKGIPAGKISARGMGESTPVTGNTCDNVKARAALIDCLAPDRRVEIEVKGYKEVVTQPAA 96.79 gnl|BL_ORD_ID|2783|hsp_num:0 3787 Z1_03331 ABC transporter ATP-binding protein uup Loose 1200 354.8 TaeA 33.07 3003986 protein homolog model n/a n/a pleuromutilin antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MPLISLTGAYLAFSDAPLLDNTDLFIDENERVCLVGRNGAGKSTLLRVLAKEQPLDDGQVVYEQDLVTARLQQDPPRDIEGTIFDFVAQGVAEDAQYITEYHRVSKVIETDPSEKNLNRLAQLQEVLDNRNLWLLDSRIAEVLEKLGLNGEAELSSLSGGWLRKAALGRALVSAPKVLFLDEPTNHLDIETILWLEKFLKDFQGSIVFISHDRSFIRNMATRIIDLDRGKLSSWPGNYDKYLESKEEALRVEEQQNAEFDRKLAQEEAWIRQGIKARRTRNEGRVRALKALRVERSERREVLGSARMQVEEATRSGKIVFELEDVNYSIGTRRLVRDFSAKVQRGDKIALVGPNGCGKTTLLKLMLGDLKADSGRIHCGTKLEVAYFDQHRATLDPDKTVMDNLAEGKQEVMVNGRPRHVLGYLQDFLFPPKRAMTPVRALSGGERNRLLLARLFLKPSNLLILDEPTNDLDVETLELLEELVDAYQGTVLLVSHDREFVDNSVTECWIFEGDGVINSYVGGYYDAQQQRAQSVSLKNEANKSRNAPEKTEKETKPKQNAKKATRSNNKLSYHLIRELEQLPAKLERLEEELGCLQEEVAAADFFTRPHEETEKVLKALADKENELETAFDRWQELEMMQNGE MNILTVEQVTKSYGDKILFQDASFGMEDQDKIGIIGVNGTGKSTFLRVIAGLEPPDSGKISMGNRIRVRYLAQNPEFDPDKTVLQQVFEGDLPEMKAVREYTETMELLELHPSHEELQQKLLKLNQTLETLQAWQLESDAKTILSKLGIRNYEAKMGTLSGGQRKRVALAAALIQPSDLLILDEPTNHIDNESVAWLEQYLQKRRGALLMITHDRYFLDRVANVMLELDHGRLFRYEANYSRFLELKAEREEREAASEQKRQNLLRSELAWIRRGAKARTTKQKARIERFEKLKDQEMVHSSGELDVSVASTRLGRKILEIEGLRMKIDDKTLIQDLSYIAVPEDRIGIVGPNGSGKSTLLNLIAGRIQPGGGEVVLGPTVKLGYFTQEHQEMDGSQRVIEYIKDEAEVVRTADGSAITAAQMLERFLFPPALQWTPIAKLSGGEKRRLYLLRVLMSAPNVLLLDEPTNDLDIQTLSVLEQYLDEFPGVCIVVSHDRFFLDRTVDKIMAFEGDGQIRVHVGSYSEYAEWMQRHGGEASGSKAEASIAKSASGSSDGTDSDSAKEAPRERLKFSYKEQREFDQIDGLIEDTESKLASIQSEMETAGSDAARLQELMKAQEETERELEHLMERWTYLNELAEKIEQSKKS 99.23 gnl|BL_ORD_ID|2238|hsp_num:0 2522 Z1_03340 Outer membrane porin protein OmpD Loose 700 411.8 Klebsiella pneumoniae OmpK37 56.92 3004122 protein homolog model n/a n/a monobactam; carbapenem; cephalosporin; cephamycin; penam; penem reduced permeability to antibiotic General Bacterial Porin with reduced permeability to beta-lactams MMKRNILAVVIPALMFAGAANAAEMYNKDGNKVDIYGKVDVRHYFADADTKGDHESGDASRARIGFKGETQINKDLTGFGRFEYEVKTNTTEGENKAKTRLAYAGLKFADFGSLDYGRNYGVIYDTNAWTDVLPLWGGDSMAQTDVYMTSRTTGVLTYRNTDMFGYVDGLSFALQYQGKNNENTNNKRKDNAEANGDGFGFSTAYNLGWGVTLGGGYSSSARTNWQEHKSDATGKRAEAWNVGGKFEANNVYLAAMYGETRNMNYYGDGAIANKTQNIELTAQYDFADLGIKPSLGYVQSKGKDLNNGVGGLKDNNHDLVKYISVGSFYKFNKNMTAVVDYKINLLDEDDFTKANGVATDNVVGLGLTYQF MKRKVLALVIPALLAAGAAHAAEIYNKDGNKLDLYGKVDGLHYFSSDSKKDGDQTYLRFGFKGETQINDILTGYGQWEYNVQANNTETSSDQAWTRLAFAGIKVGDYGSFDYGRNYGVLYDVEGWTDILPEFGGDSYTYADNFMAGRANGVATYRNSDFFGLVEGLNFALQYQGKNEGQNAQDINVGTNNRSSDSDVRFDNGDGFGLSTSYDFGMGISAAAAYTSSDRTNDQMTQTNARGDKAEAWTAGLKYDANDIYLATMYSETRNMTPYGNDGVANKTQNFEVTAQYQFDFGLRPAISYLQSKGKDLYNNGRYADKDLVKYMDVGATYYFNRNMSTYVDYKINLLDGNDKFYEDNGISTDNIVALGLVYQF 99.20 gnl|BL_ORD_ID|2634|hsp_num:0 2785 Z1_03383 Hydroxyacylglutathione hydrolase GloC Loose 500 56.2 GOB-38 25.86 3005687 protein homolog model n/a n/a carbapenem; cephalosporin; penam antibiotic inactivation GOB beta-lactamase MMYHIIPVTNYMQNCTLIWCDDTKEAAIVDPGGDVETLIAEIEQRQLKLTKVLLTHGHFDHVAGTAQIVEHFHVPVYGPHKDDNFLIEDLEQQCRMFNFPSGKSFTPDQWLNEGDTVTIGKTITLSVLHCPGHTPGHIIFVNHQNKLISMGDVLFRESIGRTDFPRGNHADLIASIKNKVLPLGDDYLFIPGHGPMSNLGHERQYNPFLQDEMPIW MRNFVILFFMFICLGLNAQVVKEPENMPKEWNQTYEPFRIAGNLYYVGTYDLASYLIVTDKGNILINTGTAESLPIIKANIQKLGFNYKDIKILLLTQAHYDHTGALQDLKTETGAKFYADKEDADVLRTGGKSDYEMGKYGVTFKPVTPDKTLKDQDKITLGNTILTLLHHPGHTKGSCSFIFETKDEKRKYRVLIANMPSVIVDKKFSEVTAYPNIQSDYAYTFKAMKNLDFDLWVASHASQFDLHEKRKEGDPYNPQLFMDKQSYFQNLNDLEKSYLDKIKKDSQDK 74.48 gnl|BL_ORD_ID|3592|hsp_num:0 4651 Z1_03387 Chloramphenicol acetyltransferase Strict 400 443.0 catA4 96.77 3004657 protein homolog model n/a n/a phenicol antibiotic antibiotic inactivation chloramphenicol acetyltransferase (CAT) MDTKRVGYTVVDLSQWGRKEHFEAFQSFAQCTFSQTVQLDITSLLKTVKQNGYKFYPTFIYIISRLVNKHAEFRMAMKDGELVIWDSVNPGYTIFHEQTETFSSLWSYYHKDINQFLKTYSEDIAQYGDNLAYFPKEFIENMFFVSANPWVSFTSFNLNVANINNFFAPVFTIGKYYTQGDKVLMPLAIQVHHAVCDGFHVGRLLNEIQQYCDEGCK MDTKRVGILVVDLSQWGRKEHFEAFQSFAQCTFSQTVQLDITSLLKTVKQNGYKFYPTFIYIISLLVNKHAEFRMAMKDGELVIWDSVNPGYNIFHEQTETFSSLWSYYHKDINRFLKTYSEDIAQYGDDLAYFPKEFIENMFFVSANPWVSFTSFNLNMANINNFFAPVFTIGKYYTQGDKVLMPLAIQVHHAVCDGFHVGRLLNEIQQYCDEGCK 100.00 gnl|BL_ORD_ID|2206|hsp_num:0 3357 Z1_03397 Lipid A export ATP-binding/permease protein MsbA Loose 1000 900.2 msbA 80.34 3003950 protein homolog model n/a n/a nitroimidazole antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MNDIDLSTWQTFRRLWPMIRIFKAGLFAAAGALIINAGVDAFMISLLKPLLDEGFGKASNDVLKWMPLAVIGLIVLRGISNFISSYCLSWVSGKVVMNMRRRLFSHIMGMPVSFFDQQSTGTLLSRITYDSEQVASSSSGALITVVREGAYIIGLFGLMFYYSWQLSLILIVIAPIVAVVIRMVSTRFRTISKRIQNSMGQVTTSAEQMLKGHKEVLIFNGQEVENKRFNHVSNHIRRQGMRMVVASSISDPIIQLIASFALAFVLYAASFPEIMDTLTAGTITVVFSSMVALMRPLKSLTNVNAQFQRGMAACQTLFAILDMEQEKDTGTLELKKPTGDIEFRNVTFQYITKDTPALKNLSFTIPEGKTVALVGRSGSGKSTIANLLTRFYDVNEGEILINGHDIRDYTLRSLRNQVALVSQNVHLFNETVANNIVYACEDQYTREDIEKAAKMAHAMDFIQKLDNGLDTEIGENGVLLSGGQRQRIAIARALLRDAPILILDEATSALDTESERAIQAALDELQKNRTSLVIAHRLSTIEKADEILVIEDGEIVERGAHLDLIERKGVYAQLHRMQFGK MHNDKDLSTWQTFRRLWPTIAPFKAGLIVAGVALILNAASDTFMLSLLKPLLDDGFGKTDRSVLVWMPLVVIGLMILRGITSYVSSYCISWVSGKVVMTMRRRLFGHMMGMPVSFFDKQSTGTLLSRITYDSEQVASSSSGALITVVREGASIIGLFIMMFYYSWQLSIILIVLAPIVSIAIRVVSKRFRNISKNMQNTMGQVTTSAEQMLKGHKEVLIFGGQEVETKRFDKVSNRMRLQGMKMVSASSISDPIIQLIASLALAFVLYAASFPSVMDSLTAGTITVVFSSMIALMRPLKSLTNVNAQFQRGMAACQTLFTILDSEQEKDEGKRVIERATGDVEFRNVTFTYPGRDVPALRNINLKIPAGKTVALVGRSGSGKSTIASLITRFYDIDEGEILMDGHDLREYTLASLRNQVALVSQNVHLFNDTVANNIAYARTEQYSREQIEEAARMAYAMDFINKMDNGLDTVIGENGVLLSGGQRQRIAIARALLRDSPILILDEATSALDTESERAIQAALDELQKNRTSLVIAHRLSTIEKADEIVVVEDGVIVERGTHNDLLEHRGVYAQLHKMQFGQ 99.83 gnl|BL_ORD_ID|2193|hsp_num:0 2423 Z1_03404 putative multidrug-efflux transporter Loose 200 99.8 sdrM 24.75 3007013 protein homolog model n/a n/a fluoroquinolone antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MSGSQYKKEDASWGMLLKGRNSLKSLALAGGVALHAINVYITITTLPSIVRDIGGLNLYAWNTTVFILASILSSALTSRLLILLAPRNSYLFATLCFLAGSIICATAPSMPILLVGRFIQGAGGGMLLALAYSLVRVMFPQPLWSRAMALMSSMWGISTLLGPALGGIFAEYNIWRGAFWSILCVGIPYAILLFTILPKENSADIANKKTSLPYLQLTLLILAVLSISIGSLYHVTLYHILSFLLAIIFILLLIYIDKRSHDGLFPKGTFSFSAPLSPIYLTMALLGISVQTEVFVPYFLQMIHGITPLLSGYLAALVGAGWSFSAIISSSQPSGIAQRLMRIGPAINFTAIIVLGLLISNYLLLPYGQVIIICLALFFTGAGIGMAWPHYLTRVLQVSQGEEAQKAATSITTIQLFSTAVGAAISGTVVNIAGLTNPGGIAGAQNAAHWLFIVFSITPLIAFITAKIVVSNIRKH MRLKSIITVIALILIMFMSAIESSIISLALPTIKQDLNAGNLISLIFTAYFIALVIANPIVGELLSRFKIIYVAIAGLLLFSIGSFMCGLSTNFTMLIISRVIQGFGSGVLMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLFYINIPIAIIAIILVIWTFHFPEEETVAKSKFDTKGLTLFYVFIGLIMFALLNQQLLLLNFLSFILAIVVAMCLFKVEKHVSSPFLPVVEFNRSITLVFITDLLTAICLMGFNLYIPVYLQEQLGLSPLQSGLVIFPLSVAWITLNFNLHRIEAKLSRKVIYLLSFTLLLVSSIIISFGIKLPVLIAFVLILAGLSFGYIYTKDSVIVQEETSPLQMKKMMSFYGLTKNLGASIGSTIMGYLYAIQSGIFGPNLHNVLSAVAVISIGLIVLWVVFFKEQSSQSKE 106.49 gnl|BL_ORD_ID|4667|hsp_num:0 5729 Z1_03420 ATP-binding/permease protein CydD Loose 1000 165.6 msbA 26.59 3003950 protein homolog model n/a n/a nitroimidazole antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MDKTKQNELVRWLKQQSAPARRWLRLSMILGVVSGLLIIAQAWLLAILLQAFIMDGLSRDTHTTTFLILISIFILRAVVMAIRERVGYRCGMAVRQQIRKIVLDRLEALGPVWVKGKPAGSWATIILEQIEDMQDYYARYLPQMYLASIVPLLILITIFPINWAAGLILFVTAPLIPLFMALVGLGAADANRRNFLALGRLSGNFLDRLRGLDTLRLFNRGDAEVKQITDATEDFRKRTMEVLRMAFLSSGVLEFFTAVSIAVVAVYFGFSYLGELSFGDYGLGVTLFSGFLALILAPEFFQPLRDLGTYYHAKAQAVGAAGSLVEFLEAEGEQPQPTGNQTINTDQGIEIVAQQLEILSHQGAKLAGPLNFTIHPKQRIALVGQSGAGKSSLLNVLLGFLPYRGSLTVNGVELTQLSPQAWRQCISWVGQNPNLPEQTLLDNIRLSDPNASEAKINQAIEKAYVSDFINELPDGLNTIIGDNAARLSVGQAQRIAVARALLSPCHFLLLDEPAASLDSHSEQRVMQALNEASLHQTTLLITHLLEETMEYDQIWVMEKGQVIETGTYQSLSQQHGVFARLLAHRKEEL MHNDKDLSTWQTFRRLWPTIAPFKAGLIVAGVALILNAASDTFMLSLLKPLLDDGFGKTDRSVLVWMPLVVIGLMILRGITSYVSSYCISWVSGKVVMTMRRRLFGHMMGMPVSFFDKQSTGTLLSRITYDSEQVASSSSGALITVVREGASIIGLFIMMFYYSWQLSIILIVLAPIVSIAIRVVSKRFRNISKNMQNTMGQVTTSAEQMLKGHKEVLIFGGQEVETKRFDKVSNRMRLQGMKMVSASSISDPIIQLIASLALAFVLYAASFPSVMDSLTAGTITVVFSSMIALMRPLKSLTNVNAQFQRGMAACQTLFTILDSEQEKDEGKRVIERATGDVEFRNVTFTYPGRDVPALRNINLKIPAGKTVALVGRSGSGKSTIASLITRFYDIDEGEILMDGHDLREYTLASLRNQVALVSQNVHLFNDTVANNIAYARTEQYSREQIEEAARMAYAMDFINKMDNGLDTVIGENGVLLSGGQRQRIAIARALLRDSPILILDEATSALDTESERAIQAALDELQKNRTSLVIAHRLSTIEKADEIVVVEDGVIVERGTHNDLLEHRGVYAQLHKMQFGQ 101.20 gnl|BL_ORD_ID|2193|hsp_num:0 2423 Z1_03421 putative ABC transporter ATP-binding/permease protein Loose 1000 187.6 msbA 26.2 3003950 protein homolog model n/a n/a nitroimidazole antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MRVLLPFLALYRRHWFMLLLGILLAILTLLASIGLLTLSGWFLAGTSLAGFAGIYSFNYMLPAAGVRGAAIFRTAGRYFERLVSHDATFRVLSHLRVFTFKKILPLSPGGIARFRQGELLNRLVADVETLDHLYIRVISPIIAAFVVIMTIMFGLGLIDARLANTLGGIMLTLLVVLPFVFYYAGKPIGRDLTDLRGQYRTVLTSMLQGQAELTIFGALPRFRQNLAQLEARWLRRQAQQANLTGLSQSLMILASGLTATLILWLAADGIDAHFMPEALIALFTFCALAAFESLGPVTVAFQHLGQVMTSATRITHLIEQQPDVTFPAQGGEIKPSASLTLRDVCFTYPNQPMPVINHVDLTIEAGQHVALLGKTGCGKSTLLQLVNRAFDPSQGVITLNHLSLADYDEATLRSMMSVVPQRVHVFSHTLRENLIMAKEDATDEELTHVLRQVGLEQLVENDEGLNAWMGDGGRQLSGGEQRRLGLARAILHNAPLILLDEPTEGLDADTEQQILALLQQHCQGKAVLMITHRLSGLDKMDKICVMDGGHIVETGTHRQLLQQQGQYAKFHQRQALLMPHDEA MHNDKDLSTWQTFRRLWPTIAPFKAGLIVAGVALILNAASDTFMLSLLKPLLDDGFGKTDRSVLVWMPLVVIGLMILRGITSYVSSYCISWVSGKVVMTMRRRLFGHMMGMPVSFFDKQSTGTLLSRITYDSEQVASSSSGALITVVREGASIIGLFIMMFYYSWQLSIILIVLAPIVSIAIRVVSKRFRNISKNMQNTMGQVTTSAEQMLKGHKEVLIFGGQEVETKRFDKVSNRMRLQGMKMVSASSISDPIIQLIASLALAFVLYAASFPSVMDSLTAGTITVVFSSMIALMRPLKSLTNVNAQFQRGMAACQTLFTILDSEQEKDEGKRVIERATGDVEFRNVTFTYPGRDVPALRNINLKIPAGKTVALVGRSGSGKSTIASLITRFYDIDEGEILMDGHDLREYTLASLRNQVALVSQNVHLFNDTVANNIAYARTEQYSREQIEEAARMAYAMDFINKMDNGLDTVIGENGVLLSGGQRQRIAIARALLRDSPILILDEATSALDTESERAIQAALDELQKNRTSLVIAHRLSTIEKADEIVVVEDGVIVERGTHNDLLEHRGVYAQLHKMQFGQ 100.17 gnl|BL_ORD_ID|2193|hsp_num:0 2423 Z1_03427 Macrolide export ATP-binding/permease protein MacB Loose 1280 597.4 macB 49.15 3000535 protein homolog model n/a n/a macrolide antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MSALLELNNVSRLYTNGEEDTVVLDQISLTINAGEMVAIIGASGSGKSTLMNILGCLDKPSSGEYKVAGQCVADMESDQLAALRREHFGFIFQRYHLMAHLTAEQNVEIPAIYAGKSTEQRKERARALLTRLGLAERIHYRPSQLSGGQQQRVSIARALMNGGEVILADEPTGALDSQSGKEVMAILKQLNQQGHTVIIVTHDPLIAQQADRIIEIKDGQIISDNNNHHSVPVKKAPPAIQTASYFHQVIGRFTQALNMAWRAMVVNKIRTLLTMLGIIIGIASVVTIIVIGDAAKDRVLADIKAIGANTIDIYPGKELGSDSPEDKQSLTIQDVDALKQQSYIQSVTPQIYFSSRLRRGNQDAPATVSGVNEDYFSVYALKFAQGSTFTPDMIHRQAQVVVIDENTRHRFFPNKQAVIGEQIIIRNIPSTIIGVVAEQKSTFGDNKSLRVWVPYSTLSSRIYNRSYLDNITVKVKEGYDASVAEQQILRLLTIRHGKKDIFTYNIDSFIKAAEKTTQTMQLFLTLVAVISLVVGGIGVMNIMLVSVTERTREIGIRMAVGARASDVMQQFLIESVLVCLVGGLLGISLSFAIAMFASMMLPNWHFVFQPTALISAFACSTAIGVIFGFLPARNAAKMNPIDALARE MSLIECKNINRYFGSGENRVHILKDISLSIEKGDFVAIIGQSGSGKSTLMNILGCLDTAGSGSYRIDGIETAKMQPDELAALRRERFGFIFQRYNLLSSLTARDNVALPAVYMGMGGKERSARADKLLQDLGLASKEGNKPGELSGGQQQRVSIARALMNGGEIIFADEPTGALDTASGKNVMEIIRRLHEAGHTVIMVTHDPGIAANANRVIEIRDGEIISDTSKNPEIPASNVGRIQEKASWSFYYDQFVEAFRMSVQAVLAHKMRSLLTMLGIIIGIASVVSVVALGNGSQKKILEDISSMGTNTISIFPGRGFGDRRSGKIKTLTIDDAKIIAKQSYVASATPMTSSGGTLTYRNTDLTASLYGVGEQYFDVRGLKLETGRLFDENDVKEDAQVVVIDQNVKDKLFADSDPLGKTILFRKRPLTVIGVMKKDENAFGNSDVLMLWSPYTTVMHQITGESHTNSITVKIKDNANTRVAEKGLAELLKARHGTEDFFMNNSDSIRQMVESTTGTMKLLISSIALISLVVGGIGVMNIMLVSVTERTKEIGIRMAIGARRGNILQQFLIEAVLICIIGGLVGVGLSAAVSLVFNHFVTDFPMDISAASVIGAVACSTGIGIAFGFMPANKAAKLNPIDALAQD 100.47 gnl|BL_ORD_ID|447|hsp_num:0 487 Z1_03428 Macrolide export protein MacA Loose 760 193.0 macA 35.34 3000533 protein homolog model n/a n/a macrolide antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MAFFLTKNQGKIIAAILIFIAIGLFFFWPKEHLPSYQTQKITRGELSKEVTATGKLDAVRKVDVGAQVSGQLQTLYVKEGDVVKKGDLLAIIDPKKAQNEVAESQETNNELTANLQQAKAELRLAQLTYQRQLKLIGTHVIAQEELDRTKTDVEVKKARVATYEAQIRKNQATLDTARTNLQYTRITAPMDGVVTFIKTLEGQTVIAAQEAPTILTLADLDTMLVKAEVSEADVIYLKPDLKASFTVLGAPDKAFNGKLKDILPTPEKINDAIFYYARFEVPNEQHLLRLQMTAQVKILLEHKKDILLVPLSALGEDVGINEYQVEVLVNGQPEKRVVKIGIRTDVYAEVISGLNENDDVILGEIAGES MAKMMKWSAVAAVAAAAVWGGWHYLKPEPQAAYITETVRRGGISRTVSATGEISPSNLVSVGAQASGQIKKLYVKLGQQVKKGDLIAEINSTTQTNTLNMEKSKLETYQAKLVSAQIALGSAEKKYKRQTALWKDDATSKEDLESAQDALAAAKANVAELKALIRQSKISINTAESDLGYTRITATMDGTVVAIPVEEGQTVNAAQSTPTIVQLANLDMMLNKMQIAEGDITKVKAGQDISFTILSEPDTPIKAKLDSVDPGLTTMSSGGYNSSTDTASNAVYYYARSFVPNPDGKLATGMTTQNTVEIDGVKNVLLIPSLTVKNRGGKAFVRVLGADGKAAEREIRTGMRDSMNTEVKSGLKEGDKVVISEITAAEQQESGERALGGPPRR 94.13 gnl|BL_ORD_ID|1549|hsp_num:0 1680 Z1_03432 Arginine transport ATP-binding protein ArtP Loose 1280 138.3 macB 39.64 3000535 protein homolog model n/a n/a macrolide antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MTIQKKRMSIQLKNINCFYGSHQALYDINLECSAGETMVLLGPSGAGKSSLMRVLNLLEMPRSGELDIAGLHFDFGQQPNAKAIRTLRQNVGMVFQQYNLWPHLTVLDNLIEAPCRVLGLAKPQAKEKAMKLLERLRLSDYAQRFPLHLSGGQQQRVAIARALMMEPQVLLFDEPTAALDPEITAQVVDIIKELSETGITQVIVTHEVEIARKAASKVVYMENGRIIEQGDNHHFTAPQTEAFANYLSH MSLIECKNINRYFGSGENRVHILKDISLSIEKGDFVAIIGQSGSGKSTLMNILGCLDTAGSGSYRIDGIETAKMQPDELAALRRERFGFIFQRYNLLSSLTARDNVALPAVYMGMGGKERSARADKLLQDLGLASKEGNKPGELSGGQQQRVSIARALMNGGEIIFADEPTGALDTASGKNVMEIIRRLHEAGHTVIMVTHDPGIAANANRVIEIRDGEIISDTSKNPEIPASNVGRIQEKASWSFYYDQFVEAFRMSVQAVLAHKMRSLLTMLGIIIGIASVVSVVALGNGSQKKILEDISSMGTNTISIFPGRGFGDRRSGKIKTLTIDDAKIIAKQSYVASATPMTSSGGTLTYRNTDLTASLYGVGEQYFDVRGLKLETGRLFDENDVKEDAQVVVIDQNVKDKLFADSDPLGKTILFRKRPLTVIGVMKKDENAFGNSDVLMLWSPYTTVMHQITGESHTNSITVKIKDNANTRVAEKGLAELLKARHGTEDFFMNNSDSIRQMVESTTGTMKLLISSIALISLVVGGIGVMNIMLVSVTERTKEIGIRMAIGARRGNILQQFLIEAVLICIIGGLVGVGLSAAVSLVFNHFVTDFPMDISAASVIGAVACSTGIGIAFGFMPANKAAKLNPIDALAQD 38.66 gnl|BL_ORD_ID|447|hsp_num:0 487 Z1_03477 dTDP-fucosamine acetyltransferase Loose 300 48.1 SAT-3 30.17 3002898 protein homolog model n/a n/a nucleoside antibiotic antibiotic inactivation streptothricin acetyltransferase (SAT) MITIRKAVLSDVEQINTLYGYLFAEMAKLQPERLKPGKQDEAFIINGIKNDKFHLLVAELEQKIVGFTIAQIQETPLFNCLVQRKYAYIFDIVVDPSVRGQGAGALLLNAMKAWAKQQKMTHLELSVLAENADAKRFYQREGLKEVSTVMGIAL MTPQSMRELVICRASDADVLQLARCDFSFEVTAELEEPFDDMRSVPVKPPYLKNYGFDADELVEHMNNSAGALFVARADNCLVGYLAVSQSWNEYAVIDDIAVDVPYRGSGVSRLLMDAAVDWARNVPSAGVRLETQSVNLAACRFYRRYGFRLGGYDRYLYRGLHPGSREVALFWYLSF 85.56 gnl|BL_ORD_ID|594|hsp_num:0 531 Z1_03482 HTH-type transcriptional regulator HdfR Loose 550 43.9 NmcR 26.06 3003665 protein homolog model n/a n/a carbapenem; cephalosporin; cephamycin; penam antibiotic inactivation NmcA beta-lactamase MTSAKRPIFNLELDLLRTFVAVADGSTFAAAAESVCRTQSAVSQQMQRLESLIGKELFARQGRNKTLTEAGTQLLNYARRILRINDEACLSLLHEEIDGILKIGSPDDTANTILPDLLARFSGAYPRLIMEIIVKRSPFLMSMLENNEVDLAISTEEHVGYPKIVLRVSPSLWYCGKHFRFDLDEPLPLVVLDEPSTYRDMMINHLDQQNIRWRIAYIATTLSGARAAVRAGLGIMARSIELSGDDLRILGEKEGLPPLPAIRYNLYLNANSPSKAAQILFDSLKNEQNEVINHADITLQNH MRARLPLNALRAFEASARYLNFTKAGLELHVSQAAVSQQVRTLEQMLGVALFTRVPRGLQLTDEGMHLLPSITEALQMMSSAMDKFHEGKIKEVLTIAVVGTFAIGWLLPRITAFLNENPWIDIRILTHNNVVNLAAEGIDASIRFGTGGWINTENILLFQAPHTVLCSPETSKKLYIPSDLKKVCLLRSYRKEEWNNWFKAAGIDPWTITGPIFDSTRLMIDAVKLGDYAALVPYHMFQKELNERSVAKPFEIYATLGGYWLTLQKSRVNHNSEALNVFKEWIIEHSREFVLKS 102.37 gnl|BL_ORD_ID|1908|hsp_num:0 2072 Z1_03491 HTH-type transcriptional dual regulator CecR Loose 420 45.1 adeN 28.32 3000559 protein homolog model n/a n/a macrolide antibiotic; fluoroquinolone antibiotic; lincosamide antibiotic; carbapenem; cephalosporin; tetracycline antibiotic; rifamycin antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; penem antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MPDTHQKKTRGELAKRQLLEAACEIFGKNGPDGATTRQIAQAAKQNIAAIAYYFGSKEGLYLAVAQYIADLIRIDFEPTVAQLDDFLEKPNPTEHLPLLQKLIIDSFLQYARLVLDKSNVHISRIMAREQLVPTEAYSLIHQQALSPLLTRVNRLLALYIGLDPTLPKTMLHTHAILGEVLSFRLVRETILRQTGWDRIGKQEYEIISNTLKVHITLLLDGLREIYTHNNHA MHDPVLESHHLVCEKPQTRRGIERRLALLLSATELFLEKGYDAVSLDDIVNHAGGSKTSIYKYFGNKDGLFTAICDYRREMFFKDICIAFQPEQTSLKDYLIQTLIRFYKPFIQPEHIAFLRLVIEQTQCNATLSQYLYEKCALDVQNTIAQALLISHQSGEITCTSPDHSSLMYFGILRDIEWRMIMGMPLPPNETEVIDYINYCVDIFLKGHHKV 106.91 gnl|BL_ORD_ID|1740|hsp_num:0 1880 Z1_03492 hypothetical protein Loose 730 70.9 farA 26.38 3003961 protein homolog model n/a n/a antibacterial free fatty acids antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MKTKKISVFIILMIIIGIIAGIYYYEENKDPELVLYGNVDIRTVNLSFRVAGKLAELQVDEGAPVTKGQLLGQLDDAPYINALNKAYGERDSAIASLALMEAGYRSEEIAQAQSDVSLKRAAWQYAENFYKRQQDLANRKVISANDLDSARNNRNQAAAALKAAQDKLNQYQNGYRQEDIDMARGQVLQAKAAVAQAELNLQDTKLTSPAEGTILTRAVEPGTILSAGSPVFTVSLTNPVWVRAYISENHLGEAIPNREVYLYTDSRKDKPYHGTIGFVSPTAEFTPKSVETPELRTDLVYRIRVVVTDADDALRQGMPVTLKFAPTH MDTHTDETKLQNTQAKRKRRLTALTLLFALAAAAAGSAFFLWWQHEEETEDAYVAGRVVQVTPQKGGTVRKVLHDDTDAVKKGDVLAVLDDDNDVLAYERAKNELVQAVRQNRRQNAATSQAGAQVALRRADLARAQDDLRRRSALAESGAVSAEELAHARAAVSQAQAAVKAALAEESSARAALGGQVSLREQPAVQTAIGRLKDAWLNLQRTQIRAPADGQVAKRSVQVGQQVAAGAPLMAVVPLSDVWVDANFKETQLRHMKIGQPAELVSDLYGKQIVYRGRVAGFSAGTGSAFSLIPAQNATGNWIKVVQRVPVRIVLNREDVDRHPLRIGLSMTVKVDTSAAGAPVSKTPGAALPEMESTDWSEVDRTVDEILGQSAP 85.42 gnl|BL_ORD_ID|2197|hsp_num:0 2428 Z1_03493 putative multidrug ABC transporter ATP-binding protein YbhF Loose 650 180.6 tetA(58) 40.17 3003980 protein homolog model n/a n/a tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MDNTNYTINLSGVEKRFIGLEKPAVASLTATITGGSVTGLVGPDGAGKTTLIRMLAGLLKPDAGEIKILGMDPQKQSVDVRAILGYMPQKFGLYEDLTVLENLNLYADLKNVIGEERKRVYQQLLSFTDLTRFTSRLAGNLSGGMKQKLGLACTLLGSPKVLLLDEPGVGVDPIARRELWQMVHTLAGDGMLILWSTSYLDEAEQCKNILLLNKGELLYSGVPQTLTAKMAGRSFLLNVEGHQRRKVLQQAIIQPQVTDGVIQGQSVRLILKKHSDQTALLNALGKPDAKLIPATPRFEDAFIDLLGGGPSHKSELAEIMPQIPPAPDETVIEAQQLTKMFGQFAATDHVDFQVKRGEIFGLLGPNGAGKSTTFKMMCGLLVPTSGKALVLGMDLKVSSGKARQHLGYMAQKFSLYSNLKVGQNLKFFSGVYGLYGKQQRNKINDMITAFGLQPMINQITDTLPLGYKQRLALACSLMHEPDILFLDEPTSGVDPLTRREFWLHINGMVDKGVTVMVTTHFMDEAEYCDRIGLVYRGKIIAAGEPDSLKQMVATEENPTPSMEDAFIGLVLDYDKKLEQENHQGSEKHE MEHAYKKKIEPKPGDLAVEAYGLIKTFGDNRAVDGVDLNVRTGTIYGVLGPNGAGKTTTIRMLATLLRPDAGSARIFGHDVQAESQIVRQLIGVTGQYASVDESLSATENLIIFSRLLGLGRKEARRKAEELLEEFGLSEAAKRPLKNFSGGMRRRLDLAASLIAQPPLIFLDEPTTGLDPRTRSQMWDTIRRLVNTGSTVLLTTQYLEEADQLADRIAVIDYGRVVAEGTADELKMSVGTSSLHLTVEDSVDMDRACHTVEQVLGVHANVSPEAGKITAPMANAGLVTDLLIELRTAGIGLSEMSVQKPTLDEVFLTITGHGVKEDAAQESYESNDREVARV 171.72 gnl|BL_ORD_ID|2251|hsp_num:0 2517 Z1_03512 Sulfate/thiosulfate import ATP-binding protein CysA Loose 570 90.5 bcrA 29.9 3002987 protein homolog model n/a n/a peptide antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MLEMNFKQTLGSLCLEVNTQLPTESITAVFGLSGAGKTSLINVIGGLTKPDSGHIVLNNHTLVDIEKKIYLPPEKRKVGYVFQDARLFPHYTVKGNLLYGMSPTMKVQFDRIIYLLGIEHLLSRFPITLSGGEKQRVAIGRALLTAPDIMLMDEPLASLDLPRKRELLPYLEKLSQDVQIPILYVSHSLDEIIRLADNVIVMDAGKIKAMGKLEDVWASSALRPWLQKETLSSVANVMVVEHHSHYAMTATAFGNQVLWLPQIEAKIGRDVRVRIDASDVSLTTTRPSNSSIRNILHMKVVEMIKHDDQVDVKLVNDGNYLWARITPWARDELNIQEGQWLYAQIKSISLSRHL MSTIIKTTDLTKMYGSQKSVDHLNINVKQGDIYGFLGRNGAGKTTTIRMLLGLIKPTSGQIEIFGENFFKNKKEILRRIGSIVEVPGFYANLTARENLLINAKIIGIHKKNAIDEVLEIVGLQHETKKLVGKFSLGMKQRLGIARALLHYPELLILDEPTNGLDPIGIKEMRRLIHSLAKERNITIFISSHILSEIEQLVDHVGIIHEGKLLEEIPFDHLKKRNRKYLEFQLSDQNKAVVLMEQHFDIHDYEVHQDGIIRVYSHLGQQGKLNKLFVENGIDVLKITMSEDSLEDYFVKLIGGGTIG 115.69 gnl|BL_ORD_ID|316|hsp_num:0 345 Z1_03526 ABC transporter ATP-binding protein ModF Loose 570 69.3 bcrA 28.44 3002987 protein homolog model n/a n/a peptide antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MKYLQLTKTQFRLSDTLCLHIDDLTINEGESWAFVGSNGSGKTALANTLCQEGILLSGELINRFTRPINLSFEKLQKMIEEEWLRNNTDLLSEDEDDTGLTVAQVIQMQVKDNDRCLLLAKQFGIDALLSRRFKYLSTGESRKVLLIQLLMNKPDLLILDEPFDGLDIDSRRTLSELLSSLHQQKLTIVLILNRFNDIPDFVQNAGLLIDCKLVAQGKKSDILSDSVIAQLSHSETLENLILPASDSVDAVPTLPPTLSPIILKDGVVSYNDKPVLHHLTWEVKPQQHWQILGPNGAGKSTLLSLITGDHPQGYSNDLTLFGRKRGSGETIWEIKRHIGYVSNALHQSYRVSSSVKNVIISGFHDSIGIYQAVTDKQQKLADEWLTLIGLTALANHPFHSLSWGQQRLVLIVRALVKHPTLLILDEPLQGLDTTNRLLVQRFIDIMISHSNTQLLFVSHHQEDAPHCITHQLIFIKEGDIYRYQQQPC MSTIIKTTDLTKMYGSQKSVDHLNINVKQGDIYGFLGRNGAGKTTTIRMLLGLIKPTSGQIEIFGENFFKNKKEILRRIGSIVEVPGFYANLTARENLLINAKIIGIHKKNAIDEVLEIVGLQHETKKLVGKFSLGMKQRLGIARALLHYPELLILDEPTNGLDPIGIKEMRRLIHSLAKERNITIFISSHILSEIEQLVDHVGIIHEGKLLEEIPFDHLKKRNRKYLEFQLSDQNKAVVLMEQHFDIHDYEVHQDGIIRVYSHLGQQGKLNKLFVENGIDVLKITMSEDSLEDYFVKLIGGGTIG 159.48 gnl|BL_ORD_ID|316|hsp_num:0 345 Z1_03534 Peptidoglycan-associated lipoprotein Loose 700 41.2 OmpA 31.76 3005044 protein homolog model n/a n/a peptide antibiotic reduced permeability to antibiotic General Bacterial Porin with reduced permeability to peptide antibiotics MQLNKVFKGLMLALPLVAVAACSSNKNDDQTDTSNNVPVTEQGPTAEELARQQLEQLKQTNIVYFGFDKYDVTSEYAQLLDAHAAFLRANPSVRITIEGHADERGTPEYNIALGERRANAVKMYLQGKGVSADQLSIVSYGKEKPAVLGHDEAAYAKNRRAVLVY MRSFVTSWRILDDNEAQKMKKTAIAIAVALAGFATVAQAAPKDNTWYAGGKLGWSQYHDTGFYGNGFQNNNGPTRNDQLGAGAFGGYQVNPYLGFEMGYDWLGRMAYKGSVDNGAFKAQGVQLTAKLGYPITDDLDIYTRLGGMVWRADSKGNYASTGVSRSEHDTGVSPVFAGGVEWAVTRDIATRLEYQWVNNIGDAGTVGTRPDNGMLSLGVSYRFGQEDAAPVVAPAPAPAPEVATKHFTLKSDVLFNFNKATLKPEGQQALDQLYTQLSNMDPKDGSAVVLGYTDRIGSEAYNQQLSEKRAQSVVDYLVAKGIPAGKISARGMGESTPVTGNTCDNVKARAALIDCLAPDRRVEIEVKGYKEVVTQPAA 44.12 gnl|BL_ORD_ID|2783|hsp_num:0 3787 Z1_03541 Multidrug resistance protein 3 Loose 900 100.5 emrB 24.18 3000074 protein homolog model n/a n/a fluoroquinolone antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MSYRYQIAIIFLLGFFIDCINIFMSAIALPAIAADMKVSIVSITWVSNSYILGLTLIIPLSHWLSQRFGVRVLMVSSMLIFSASVALVGYSHSFFELILWRFIQGLSGGLLIPIGQALTFQYFQGHERSKVSTLIMAVALIAPAISPTIGGFIVDAVSWRWVFYSNVPFSLLTAFLAFIWVKESKSQENIIPDLKGILLISIIIVSGLCALSAYGEYHSTQLALVISFFAALFSLLYYRHYKQSLSPVINLNLLKNRNLSLSIFLYYCIPGVFTGVNILAIFYLQQYLHFSGQGTGSFMLLYAIGAFISIIVGGALYNKLGMKRLAIFALILHSIGIALLALVDKESDLPLLILAYLMMGIGGGIGANTAQTTALYDFDKQRLIQASVIWNINRQVVFSVGATLVAMIFNTLSLFVSSQMAYSTTFFICATIGLFPLFLFILLKQKTNLQETNHEH MQQQKPLEGAQLVIMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPLTGWLAKRVGEVKLFLWSTIAFAIASWACGVSSSLNMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGVAVVLMTLQTLRGRETRTERRRIDAVGLALLVIGIGSLQIMLDRGKELDWFSSQEIIILTVVAVVAICFLIVWELTDDNPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGIIPVILSPIIGRFAHKLDMRRLVTFSFIMYAVCFYWRAYTFEPGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERLAAASSLSNFTRTLAGSIGTSITTTMWTNRESMHHAQLTESVNPFNPNAQAMYSQLEGLGMTQQQASGWIAQQITNQGLIISANEIFWMSAGIFLVLLGLVWFAKPPFGAGGGGGGAH 89.06 gnl|BL_ORD_ID|1709|hsp_num:0 1847 Z1_03542 HTH-type transcriptional regulator DmlR Loose 650 105.1 adeL 26.44 3000620 protein homolog model n/a n/a fluoroquinolone antibiotic; tetracycline antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MQNQIDRIRSFIAVVDTGSFTQAAKYLRLSKSMVSIHIKALETELNVSLLNRNTRRFTLTETGEILYQDFRQVLVQLEQTLDKARLGQQNLQGTLRLTSTAEFGEHYILPLLHQFMCLHPQLKVQYIFNSSIDDLINHKLDLAIRLGALKDSNYRYRKLADYTIKLVVSPHLLKKYPIQEIADLAAVPYLANSNLRHSKLSQQEKINQLFSQLHSMALFETNTISALKQMALKQMGMTILPEWYIQQEITQGELVSPIPELTLLNQSINVIFPHGEHMPRKTRLFIDFLKERINSMP MRVFNKVVETNSFSLAADSLGLPRASVTTTIQALEKHLQVRLLNRTTRKISLTPDGAVYYDRTARILADVADIESSFHDAERGPRGQLRIDVPVSIGRLILIPRLRDFHARYPDIDLVIGLNDRPVDLVGEAVDCAIRVGELKDSSLIARRIGTFQCATAASPIYLEKYGEPTSIEDLQKNHKAIHFFSSRTGRNFDWDFVVDDLIKSVSVRGRVSVNDGDAYIDLALQGFGIIQGPRYMLTNHLESGLLKEVLPQWTPAPMPISAVYLQNRHLSLKVKVFVDWVAELFAGCPLLGGTALPFDQKCEFACDKETGHEYTIRTLVEQHNIAEAYTLKT 88.13 gnl|BL_ORD_ID|2323|hsp_num:0 2654 Z1_03557 Inner membrane transport protein YdhC Loose 500 111.3 bcr-1 28.39 3003801 protein homolog model n/a n/a bicyclomycin-like antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MNRKLSLWLAIALMMFPQIAETIYSPALTDISNGFRVSANEAGQTLSLYFFAFALGVIIWGRLCDVIGRRPTMLAGLFIYAIACIGVFMTDNFSVLLILRMLSAFGAAVGSVGTQTIMRDVYSGEELAKVFSVMGAAIALSPAIGMLSGSLLVSYAGYQGVFSGLALLAVVLLLWSTIALPESRPATIKTAPLAETAIKMLKDKQIAKTILLIAFFNISLFAYYQLAPFMFDNQGYSASTFGYSGIVLAIGVGIGSYINKALLSHHWQCEKLVLLASIIAVISAVSVYLLRNHISFIIPMMTSVVAYGIAIPNILATALAQYKDRLGTAGALLGLFYYLLIGGGLALAGWGQSLAITLLICSIGALLLSFSRQTAK MPASASRIQVGSGERRLLLLLSALVAFGPLSIDMYLPSLPAIAADLGASDAQVQRSISGFLVGFCVGMLFYGPLSDRFGRRPVLLAGIALYLFSSLACALADSAGQLVLLRVLQALGGGAASVLARAMVRDLYPLGEAARMLALMHMVTMLAPLAAPLLGGYLMLWAGWRALFVVLALFAGLCLLAVWRVAESHPPERRGGSLAQAFLAYGRLLGDRRALGYVLCMGLAFAGMFAYISAAPFVFIEHFGVRAERFGWFFGLNILGVMLATWCSARLVRRHGPRPLLRAGSLLACVSGLFLLGYAALGERGGLWALVPGLLCFVSVTGLLGANCIASLLALYPGQAGAASAVAVSGQFGLGCLASLAVGWLALPGVLPMALVMAVCGVGSLLALGLALHGGNR 93.53 gnl|BL_ORD_ID|2340|hsp_num:0 2303 Z1_03674 3-demethoxyubiquinol 3-hydroxylase Loose 600 78.6 Streptomyces venezuelae rox 25.07 3007209 protein homolog model n/a n/a rifamycin antibiotic antibiotic inactivation rifampin monooxygenase MMRNVKNDFDAVIAGGGMIGAAVAIGLAQEGLRVAMVERQSPAPFDASSHPDIRISAISCASVSLLKQLGAWQHVLAMRSAPYLTLETWEEDNAHVIFDAKSLGLPELGYMVENRILQLALWQEAERYSNITLLCPNSLSNMKYLDNKWQVTLADGQEITTQLVVGADGANSQVRQMAGIGSNGWQYRQSCMLITVKTQLPPEKGTWQRFYPSGPRAYLPLFDNWACLVWYDSPQRIRKLQTMPMAQLEKEIEHAFPERLGKVTPIAAGSFPLTRQHASRYVDNGVILVGDAAHTINPLAGQGVNLGYRDVDCLLNLVAQAKQHFEPWHSMALLKKYQRRRMPDNMLMQAGMDLFYHAFSHQLPGLKLARNIGLLAAQHAGKAKEAALRYALGIK MFDVIVVGGGPTGLMLAGELRLHGVRVLVLEKETEPTRQSRAQGLHVRSIEVMAQRGLLERFLERGHTVAVGGFFAGLATSWPERLDTAHSYVLAVPQVITEQLLAEHATALGAEIRRGRALVGLRQDEDGVTVDLADGEQLRARYVVGCDGGRSTVRKLLGVAFPGEPSRVETLLGEMEMTASQEELTSVMTEVRKTQQRFGAMPLGDGVFRVVVPAEGVAEDRTASPTLDEFKQQLRAHAGTDFGVHSPRWLSRFGDATRQAERYRVDRVFLAGDAAHIHPPTGGQGLNLGIQDAFNLGWKLAAEVDGWAPEGLLDTYHAERHPVATEVLDNTRAQIQLMSTEPGPQAVRRLMAELVEFENVNRYLIEKITAISVRYDVGEGHELLGRRMRDLALKHGRLYERMHEGRGLLLDQTGRLSVAGWEDRVDHVVEVSEELDVPAVLLRPDGHVVWAGEDQQELLTRMPAWFGAATAG 82.98 gnl|BL_ORD_ID|4836|hsp_num:0 5820 Z1_03688 Glutamine transport ATP-binding protein GlnQ Loose 1280 124.8 macB 35.37 3000535 protein homolog model n/a n/a macrolide antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MISLKDVSKWYGQFQVLTDCSTEVKKGEVVVVCGPSGSGKSTLIKTVNGLEPIQQGEILVNDIKVNDKRTDLAKLRAKVGMVFQHFELFPHLSIIENLTLAQVKVLNREKGAAKEKGLKLLERVGLANHANKYPAQLSGGQQQRVAIARALCMDPIAMLFDEPTSALDPEMINEVLDVMVELANEGMTMMVVTHEMGFAKKVADRIIFMDEGRIVEDSPKNDFFDNPKSERAKDFLAKILH MSLIECKNINRYFGSGENRVHILKDISLSIEKGDFVAIIGQSGSGKSTLMNILGCLDTAGSGSYRIDGIETAKMQPDELAALRRERFGFIFQRYNLLSSLTARDNVALPAVYMGMGGKERSARADKLLQDLGLASKEGNKPGELSGGQQQRVSIARALMNGGEIIFADEPTGALDTASGKNVMEIIRRLHEAGHTVIMVTHDPGIAANANRVIEIRDGEIISDTSKNPEIPASNVGRIQEKASWSFYYDQFVEAFRMSVQAVLAHKMRSLLTMLGIIIGIASVVSVVALGNGSQKKILEDISSMGTNTISIFPGRGFGDRRSGKIKTLTIDDAKIIAKQSYVASATPMTSSGGTLTYRNTDLTASLYGVGEQYFDVRGLKLETGRLFDENDVKEDAQVVVIDQNVKDKLFADSDPLGKTILFRKRPLTVIGVMKKDENAFGNSDVLMLWSPYTTVMHQITGESHTNSITVKIKDNANTRVAEKGLAELLKARHGTEDFFMNNSDSIRQMVESTTGTMKLLISSIALISLVVGGIGVMNIMLVSVTERTKEIGIRMAIGARRGNILQQFLIEAVLICIIGGLVGVGLSAAVSLVFNHFVTDFPMDISAASVIGAVACSTGIGIAFGFMPANKAAKLNPIDALAQD 37.42 gnl|BL_ORD_ID|447|hsp_num:0 487 Z1_03689 Leucine--tRNA ligase Loose 2200 80.1 Bifidobacterium bifidum ileS conferring resistance to mupirocin 26.88 3003730 protein homolog model n/a n/a mupirocin-like antibiotic antibiotic target alteration antibiotic-resistant isoleucyl-tRNA synthetase (ileS) MQEQYRPEDIEQTIQEHWEKNNTFKVTEDNNKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVISRYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYENINYMKGQLKKLGFGYDWDREVTTCTPEYYRWEQWFFTKLYEKGLVYKKTSAVNWCPHDLTVLANEQVIDGCCWRCDTPVERKEIPQWFIKITDYAEELLNDLDTLDEWPEQVKTMQRNWIGRSEGVEITFDVADSDDTMTVYTTRPDTFMGVTYVAVAAGHPLAQKAAQNNPEIQHFIDECRNMKMAEAEMATMEKKGIATGLYAIHPLTQEKVAIWVANFVLMEYGTGAVMAVPGHDERDWEFATKYGLPIKAVIADAEGNQPDLSTGALTEKNSLINSGEFSGLDNQAGFNAIADKLTAMGVGERKVNYRLRDWGVSRQRYWGAPIPMATLEDGSVVPVPDDQLPVILPEDVKMDGITSPIKADPEWAKTTINGQPALRETDTFDTFMESSWYYARYTCPDYDKGMLDPKAANYWLPVDWYIGGIEHAIMHLMYFRFFHKLMRDAGLVNSDEPAKRLLCQGMVLADAFYYTGEDGARHWVSPAEAIVERDEKNRIIKATDSAGHELTYAGMSKMSKSKNNGIDPQTMVERYGADTVRLFMMFAAPPELTLEWQESSVEGANRFLRRLWRLVHEHTEKGTTQSLDLATLTTEQKDLRRDLHKTIAKVSDDVGRRLAFNTAIAAIMELMNKLTRAPQETEQDRALMQEALEAVVRMLSPIIPHACFVMWQALGGKEDIDVAPWPVADEEAMVDDTKLIIVQVNGKVRGRITVPANSEKDYVQEMATKEYSVAKYLENVTVRKVIYVPGKLLNIVVG MSETTNSHVYPKANEGGETASVAPNPSFPNMEETVLKYWDKDDTFNKSVERNPSGDHSQNEFVFFDGPPFANGLPHYGHLLTGYAKDVIPRYQTMKGRKVNRVFGWDTHGLPAELEAQKELGIDSVDQIEKMGIDKFNDACRASVLKYTHEWQDYVHRQARWVDFEHGYKTLNIPYMESVMWAFKQLYEKGLAYQGYRVLPYCPKDQTPLSAHELRMDADVYQDRQDTTVSVAVKLRDEEDAYAVFWTTTPWTVPTNFAIVVGADIDYVEVRPTQGKYAGKKFYFGKPLLSKYEKELGEDYEVVRELKGSEMAGWRYWPVFPYFAGDKAESEGNVPGPEGYQIFTADYVDTVEGTGLVHQAPYGEDDMNTLNAHGIKSTDVLDAGCRFTAQCPDYEGMYVFDANKPILRNLRNGDGPLAEIPAEHRAILFQEKSYVHSYPHCWRCATPLIYKPVSSWFVSVTKIKPRLLELNQQINWIPENVKDGQFGKWLANARDWSISRNRFWGSPIPVWVSDDPKYPRVDVYGSLEELKADFGDYPRDKDGNVNMHRPWIDNLTRVNPDDPTGKSHMHRISDVLDCWFESGSMSFAQFHYPFENKEKFEQHFPADYIVEYIGQTRGWFYLLHVMATALFDRPAFKNVICHGIVLGSDGQKMSKHLRNYPDVNGVFDKYGSDAMRWFLMSSPILRGGNLIVTAEGIRDTVRQVMLPVWSSYYFFTLYANAANGGAGFDARQLRADEVAGLPEMDRYLLARTRRLVERVEKSLDEFAISDACDAASDFIDVLTNWYIRNTRDRFWKEDVNAFNTLYTVLEVFMRVLAPLAPMESESVWRGLTGGESVHLADWPYVADEKTGEATELGRVLVDDPALVDAMEKVREIVSGALSLRKAAQIRVRQPLAKLTVVVEDVDAVKAYDEILKSELNIKDIEFCTMEDAGSQGLKIVHELKVNARAAGPRLGKQVQFAIKASKTGAWHVDAATGAPVVETPNGEVALEAGEYELINRVEEENAAEADASVSAALPTGGFVILDTVLTADLEAEGYARDVIRAVQDARKAADLDIADRIALVLTVPSANVADVERFRDLIAHETLATSFAVKEGAELGVEVAKA 77.69 gnl|BL_ORD_ID|4703|hsp_num:0 2278 Z1_03696 Peptidoglycan D,D-transpeptidase MrdA Loose 1000 287.7 Helicobacter pylori pbp2 mutants conferring resistance to amoxicillin 31.5 3007058 protein variant model E572G R384G:320 cephalosporin; cephamycin; penam antibiotic target alteration Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics MKSTNGMKKRKRTPFRDYTAESKLFIRRVIVAFSGILVLTGILVFNLYHLQVARHDDYQTRSNDNRIKLVPIPPSRGIIYDRNGVPLALNRTIYQLEIVPEKVANIQETLESLREVVDLTDDDIAAFEKERKRSRRFSSIPLKTSLDQVQVARFAINQYRYPGLEIKGYQRRYYPYGSALTHVIGYVAKINDKDVERLEKEGLYPNYAATRDIGKLGIERYYESVLHGKTGYEEVEVNSRGRVIRQLHEQPPQAGKDIYLTIDLELQTYIETLLTTSRAAVVVTDPRNGEILALVSNPSYDPNLFVGGISNTDYQGLLNNPDRPLINRATQGLYPPASTVKPFMSVAALSEGVITPNTTIHDPGWWQLPGSEKRYRDWKRWGHGKLNVTKSIIESADTFFYQVAYDMGIDRISTWMSRFGYGEYTGIDLSEERNGIMPTREWKQQRYKKPWYQGDTIPVGIGQGYWTATPIQMSKALMTLINDGQVKTPHLLYGTKLGNEMLPYVDKETRQIGDINSGYWELAKYGMYGVANLPNGTGRRSFADAPYKIAAKSGTAQVFSYETYNASQLAEHLRDHKLMIAFAPYENPTVAVSIILENGGAGPSVGDITRQILDHIILGDNNTELPISPPSPRGSEE MKNLRYKLLLFVFIGFWGLLVLNLFILSVKNQEYYEKLAERNMTKKEFLVPTRGDITDRNDEFLATNELVFGVFLPSRLKQKELLEKIEIIQKFFPNFSKETLLNNYQKENSLYNHNLIKVVGFIPYIAMQPLYAKLIQTQGIFALPLDKRYYPNNALASHVLGYVGVASLQDLKDDEENQYSQIVGKTGIEKEYNKLLQGKVGYKIMRVNALNQELATLEVVPPSTNNHLQLSLDKRLQKEADKLFENKRGAILVMNAENGELLVAGSYPEYNLNDFVGGISQDKWQKLQDDIYNPLLNRFANALYPPGSVVKMGVGLSFLENLHITENTTIPTPPFIEVGKRKFRDWKKTGHGNSNLYKAIRESVDVYFYKFGLEISIEKLSKTLREVGFGEKTGVDLPNEFVGIVPDNLWKLKRFNQDWRVGDTLITAIGQGSFLATPLQVLAYTGLIATGKLATPHFAINNKQPLKDPLNSFQKKKLQALRVGMYEVCNHKDGTAYHSTRGSKVTLACKTGTAQVVEIAQNIVNRMKEKDMEYFHRSHAWITAFLPYEKPKYAITILVEHGEGGSKLGGLLVKMSNKLYELGYL 108.33 gnl|BL_ORD_ID|4767|hsp_num:0 5757 Z1_03703 Putative fluoride ion transporter CrcB Loose 250 55.8 CrcB 33.33 3005049 protein homolog model n/a n/a aminoglycoside antibiotic antibiotic efflux multidrug and toxic compound extrusion (MATE) transporter MLNIAIAVFIGGGLGSVLRWLISYRLNSLFPHFATGTLVANCIGAFIIAFGIAWFSKAPNIDPIWKIMLTTGFCGGLTTFSTFSVEVVALFNEGRIGWALGTMGANLAGSFLMTAFAFWLLREM MLNFTILIFVGGAFGAICRELLMLVVPRLSDGFPLDIFIANIIAAFLLGLCTSLYKRNRVNQYIHMMVATGIMGGLSTFSSFVSGAVEMMNEPLSALIAICYLVISLIVGFMAVELGLRLGSRVKPAPPMTHNRSTG 90.51 gnl|BL_ORD_ID|2789|hsp_num:0 3792 Z1_03711 Glycine betaine/choline transport system ATP-binding protein OusV Loose 500 120.2 RanA 30.54 3005091 protein homolog model n/a n/a aminoglycoside antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MAIKLEVKNLYKIFGEHPKRAFELLESGMNKDQIFDKTGLTVGVQNANLAIEEGEIFVIMGLSGSGKSTLVRLLNRLIDPTKGEVLIDGENITTMSDKDLRQVRRKKISMVFQSFALMPHMNVLDNTAFGMELAGISKEERYEKAMAALEQVNLSSHAQSWPDELSGGMRQRIGLARALANDPDILLMDEAFSALDPLIRTEMQDELLSLQGDKQRTIVFISHDLDEAMRIGDRIAIMQGGVVVQIGTPDEILNNPANDYVRTFFRGVDISHVFSAKDIAKRRPETLLHIAPGFGPRSALKVLEDEDRNFGYLIERGRKFAGIVSVTSLEEALKAKQPIGSAILTEPCAINGDTPLNELISTVAQSPCAIPVIDEKNRYIGLISKGMLLQALDKETPNE MIEVKDLRKSFNDVEVLKGITTTFETGKINLVIGQSGSGKTVFLKCLLNVFDPSSGDILFDGRNLSIMGRTEKQEIRSEIGTVFQGSALFDSMTVEENISFPLDMFTNLTYTEKRKRVKEVIGRVHLENANTKFPSEISGGMQKRVAIARAIVNNPKYLFCDEPNSGLDPNTAIVIDELIKEITEEYNTTTIINTHDMNSVLTIGEKIVYLRKGVKEWEGNKDLIIKAENEHLIDFVYSSALFKQVRETMLRNNQTNL 154.65 gnl|BL_ORD_ID|2817|hsp_num:0 3825 Z1_03716 Transcriptional repressor MprA Loose 280 224.6 emrR 68.64 3000516 protein homolog model n/a n/a fluoroquinolone antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MESSFTPTEELLNTRATQQKSLNKDIPYQEILLTRLSMHVQSKLLESRNNMLKSQGINETLFMALMILDTTENRSIQPSELSAALGSSRTNATRIADELEKQGWIERRESHNDRRCLHLHLTDAGEEFLNSLLPPQHECLKKIWSVLDEGEQKQLETLMRKLLLQLDTLADNQQE MDSSFTPIEQMLKFRASRHEDFPYQEILLTRLCMHMQSKLLENRNKMLKAQGINETLFMALITLESQENHSIQPSELSCALGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHEFLREVLPPQHNCLHQLWSALSTTEKDQLEQITRKLLSRLDQMEQDGVVLEAMS 99.43 gnl|BL_ORD_ID|1228|hsp_num:0 1330 Z1_03718 Staphyloferrin B transporter Loose 700 288.5 mdtG 42.08 3001329 protein homolog model n/a n/a phosphonic acid antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MVYQLGIPEKNISMTQLYNSFWRRNLLVCFIGSFSTVFAMTLMLPFLPLYVEELGVQGHAAIVQWSGVAFSATFITAGLIAPVWGKLGDKYGRKSMLVRASLGMAVTVSLMGMVTNIWQLVGLRLLVGLAGGYSSGATILIAVQAPRERVAWALGIVSCGVMAGNLIGPLAGGWLPDLFGIRNTFFCAGALIFLSFIMTLTLIREDTPKYINTTTKMQVSWSQLPARFVIVSMLCTGLLLMLANMSIEPIITVYVRTLVNDPAQITRVAGYVMATAALGSIISASWLGKLADRIGHLRIITLALAIAGLLLIPQAFVTSGWQLIILRFLMGLALGGLLPCIAAVIRHHVPEGMIGSILGYSVAAQFAGQFIGPLIGGVIGGHIGMRAVFLATSVVLLLGAAWNFKLHRNSVIR MSPCENDTPINWKRNLIVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSALNMWSGIVFSITFLFSAIASPFWGGLADRKGRKLMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPMAGGLLADSYGLRPVFFITASVLILCFFVTLFCIREKFQPVSKKEMLHMREVVTSLKNPKLVLSLFVTTLIIQVATGSIAPILTLYVRELAGNVSNVAFISGMIASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSYVQTPLQLGILRFLLGAADGALLPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISANYGFRAVFLVTAGVVLFNAVYSWNSLRRRRIPQVSN 101.23 gnl|BL_ORD_ID|551|hsp_num:0 603 Z1_03720 Multidrug export protein EmrA Loose 700 474.2 Klebsiella pneumoniae KpnG 63.43 3004588 protein homolog model n/a n/a macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; penam; peptide antibiotic; penem antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MSVNEEKNPPQAPIRNKKRTRRNVLLLLTFIFILAGLAYTAYWFMVLRHHETTDNAYVTGNQIMVMPQISGSVTTVYVDNTDYVKAGEPLVQLDDSDEILALDKAKTALANSVRQMHQQIINGRQLKANIVLRETELAKLQNDLRRREVLGERNVIGKEELQHAREAVATAKAALDVAKEQYNANQAIILTTPIAQQPSVLQAATEVRNAWLALQRTKILSPAEGYVSRRSVQVGAQVAPGKPLMAVVPVTGMWIDANFKETQLANMRIGQPAKITTDFYGKKVIYHGRVQGLDMGTGSAFSLLPAQNASGNWIKVVQRLPVRISLDEKEVAEKPLRIGLSTEVTVDTVNLDGKVLSQSERQAPAYHTDALTIDMSEINSLINEIIEQNAG MSANAESQTPQQPGSKKGKRKGALLLLTLLFIIIAVAYGIYWFLVLRHYEETDDAYVAGNQVQIMAQVAGSVTKVWADNTDYVQKGDPLVTLDRTDAQQAFEKAKTQLAASVRQTRQQMINSKQLQANIDVKKTALSQAQADLNRRIPLGAANLIGREELQHARDTVASAQAELDVAIQQYNANQAIVLGTRLEQQPAVLQAATEVRNAWLALQRTQIVSPISGYVSRRSVQPGAQIGTTTPLMAVVPATNLWIDANFKETQLAHMRIGQPATVISDIYGDDVKYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLPVRIELDEKQLAEHPLRIGLSTLVEVNTTDRDGEMLASQVRSSPVYESNAREIALDPVNKLIDEIIQANAG 100.26 gnl|BL_ORD_ID|2740|hsp_num:0 3298 Z1_03721 Multidrug export protein EmrB Strict 700 767.3 Klebsiella pneumoniae KpnH 72.71 3004597 protein homolog model n/a n/a macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; penam; peptide antibiotic; penem antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MIKEPLQGGKLAIMTIALALATFMQVLDSTIANVAIPTIAGNLGASNSQGTWVITSFGVANAISIPITGWLAKRIGEVRLFMWSTALFALTSWLCGISQSLEMLIFFRVLQGLVAGPLIPLSQSLLLNNYPPAKRNMALALWSVTIVVAPILGPILGGYISDNYHWGWIFFINVPFGVLIIMCISNTLAGRETKTEIKPIDTIGLVLLVVGVGALQIMLDQGKELDWFNSTEIIVLTIIAVVALSFLIVWELTDEHPVIDLSLFKSRNFTIGCLTLSLAYMIYFGTIVLLPLLLQEVFGYTATWAGLAAASVGLLPLIITPIIGKFGGKVDLRYIISFSFIMFAVCFYWRAYTFEPGMDFATVAWPQFWQGLGVACFFMPLTTMTLSGLPPEKMASASSLSNFLRTLAGAIGASLTTTIWTQRESLHHETFVEKINPLDPDAQLAFQQMRELGLSDEQTSAYLAKTITEQGLIISANEIFWLAAGIFILMLVVVWFAKPPFSPGK MQQQKPLEGAQLVIMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPLTGWLAKRVGEVKLFLWSTIAFAIASWACGVSSSLNMLIFFRVIQGIVAGPLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGVAVVLMTLQTLRGRETRTERRRIDAVGLALLVIGIGSLQIMLDRGKELDWFSSQEIIILTVVAVVAICFLIVWELTDDNPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGIIPVILSPIIGRFAHKLDMRRLVTFSFIMYAVCFYWRAYTFEPGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERLAAASSLSNFTRTLAGSIGTSITTTMWTNRESMHHAQLTESVNPFNPNAQAMYSQLEGLGMTQQQASGWIAQQITNQGLIISANEIFWMSAGIFLILLGLVWFAKPPFGAGGGGGGAH 98.63 gnl|BL_ORD_ID|2741|hsp_num:0 3299 Z1_03722 putative tRNA/rRNA methyltransferase YfiF Loose 450 45.1 tsnR 27.46 3003060 protein homolog model n/a n/a peptide antibiotic antibiotic target alteration non-erm 23S ribosomal RNA methyltransferase (A1067) MNDSYEGKNGKVKVMYVRSEDSADNKPKKPSRRPNNARGDTDRSHRRDDKRGDNKFSRRDERGAGKSSGRNPSRSGSSSSRDNNSEGGNYSPWKTISRPGDEPLKEHDGITGKSQIDPEQLRRQRLEETRIYGENACQAMFKNRPEAIVRAWFLQEVTPRFREALKWMAANRKAYHVVEEEEMVKAARTDHHGGVCFLIKKRVGHDAQTYLKDAPTKDCVLALEDVGNPHNVGAIMRSCAHFGVKGVISPDSSVLESGAAVRTAEGGAEYIQGIDADNFAQTLEQFKQAGYTLVTTSSHKGSVPLAKAQLPEKMVLILGQEKDGLSDSTLKQGDMSIYIGGTGHIESLNVSVASGVLLAEWWRQHHG MANLDVIVDRSDPAVQRIVDVTKHSRSVVRTVLIEDIEPLTQSIRAGVEFTEVYGLDTVPFPGDLLAACEKRGIRVRLLSAAVANQVFKTEKKPKVFGIAKVPPAGRFADLESLSGDVVLLDGVKIVGNIGAIVRTRSALGAAGIVLVDSGLGTIADRRLIRASRGYVFSLPIVLATRDEALAFFRDGGMRPVVFEADGKLSIGELDGIDERLVLVFGSEKTGPSGEFAGVATESVSIPMNPAAESLNVSVSAGIALHRRARRNLSRPRG 135.93 gnl|BL_ORD_ID|149|hsp_num:0 49 Z1_03759 Translational regulator CsrA Strict 100 102.8 rsmA 92.98 3005069 protein homolog model n/a n/a fluoroquinolone antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MLILTRRVGETLMIGDDVTVTVLGVKGNQVRIGVNAPKEVSVHREEIYQRIQAEKTQPTDNY MLILTRRVGETLMVGDDVTVTVLGVKGNQVRIGVNAPKEVAVHREEIYQRIQKEKDQEPNH 101.64 gnl|BL_ORD_ID|2801|hsp_num:0 3807 Z1_00159 Penicillin-binding protein 1B Loose 1300 254.2 Helicobacter pylori pbp1 mutants conferring resistance to amoxicillin 31.62 3007060 protein variant model S414R, I450V cephalosporin; cephamycin; penam antibiotic target alteration Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics MSRKKKPVKKTNRRRSWFWLFVKIAIVVAVLVGIYGVYLYSQIKERLDGNVWELPAAVYGRTVNLEPGMNYSQKEMVSLLEGMQYRHVNKITRPGEFVVKNGTIEMLRRPFDFPDGREEQILAKLTFEQNSLVSITNMNNQRQFGFFRLDPKLITMMQSANGEQRLFLARDKFPQLLVDTLIATEDRRFYEHDGISIYSIGRAVLANFTAGRAVQGGSTLTQQLVKNLFLTNERTLKRKLNEAYMAIIMDASYSKDRILELYLNEVFLGQSGDEQIRGFPLASLYYFGRPVDELSLDQQALLVGMVKGASAYNPWRNPKAALERRNVVLKLLQTQQIIDQELYDVLSARPLGVKPRSEALTPQPAFMQLVRQELQTKLGDQVKDLSGTKIFTTLDPVSQDAAEKAVEAGVADLRKTRKINDLEGAMVVVDRLSGEVRALVGGSQPQYAGFNRAMSARRSIGSLAKPATYLTALSEPERFRLNTWLADEPISVPIPGGKPWQPRNYDRGYKGRLMLVDALATSRNVPTVNLGLEVGLDQVIKTWIKLGAPAENLEKVPAMLLGALNLTPMEVAQTFQTIGSLGNRAKLSALRSVITQDGTVLYQSYPQAETTVSPQAAYMTLFGMQQVVNSGTAARALKPKFGQYNLAGKTGTTNDLRDSWFAGIDGKEVTIAWMGRDNNGPTNLTGSTGALILYRHYLENQTPLTLNPPVPEDIAQMSINAEGNFVCYGGGVRTLPVWTADPDSLCTPLPQESDGDDSAAPKWLRDLFSE MLKKIFYGFIVLFLIIVGLLAILIAQVWVTTDKDIAKIKDYRPGVASQILDRKGRLIANIYDKEFRFYARFEEIPPRFIESLLAVEDTLFFEHGGINLDAIMRAMIKNAKSGRYTEGGSTLTQQLVKNMVLTREKTLTRKLKEAIISIRIEKVLSKEEILERYLNQTFFGHGYYGVKTASLGYFKKPLDKLTLKEIAMLVALPRAPSFYDPTKNLEFSLSRANDILRRLYSLGWISSNELKSALNEVPIVYNQTSTQNIAPYVVDEVLKQLDQLDGLKTQGYIIKLTIDLDYQRLALESLRFGHQKILEKIAKEKPKTNASNEDEDNLNASMIVTDTSTGKILALVGGIDYKKSAFNRATQAKRQFGSAIKPFVYQIAFDNGYSTTSKIPDTARNFENGNYSKNSKQNHAWHPSNYSRKFLGLVTLQEALSHSLNLATINLSDQLGFEKIYQSLSDMGFKNLPKDLSIVLGSFAISPIEAAEKYSLFSNYGTMLKPMLIESITNQQNDVKTFTPMETKKITSKEQAFLTISVLMNAVENGTGSLAHIKGLEVAGKTGTSNNNIDAWFIGFTPTLQSVIWFGRDDNTPISKGATGGVVSAPVYSYFMRNILSIEPSLKRKFDVPKGLRKEIVDKIPYYSTPNSITPTPKRTDDSEERLLF 116.84 gnl|BL_ORD_ID|4768|hsp_num:0 5758 Z1_00171 Membrane sensor protein UhpC Loose 800 236.5 Staphylococcus aureus GlpT with mutation conferring resistance to fosfomycin 33.49 3003901 protein variant model A100V phosphonic acid antibiotic antibiotic target alteration antibiotic-resistant GlpT MLGKNSASINKTYDFWRKNLMLSMIIGYATFYLTRKSVNFVMPVMQTELHLDKSDIGWIASLFYLTYGLSKFLSGIFHDQYGYRWFMGAGLVMTGVMNIIFAYCLSFPALLLVWALNGFFQGWGWPPCARLLTHWYSRNERGFWWGLWNISINLGGMSIPLLTAWLATHFSWQIALVIPGLIGIVMGLWLCMQLKGTPAEEGLPTVGVWRRDIFELRQEQVSPPTPMLTILKESILFNRMIWLLGFSYILIYLIRMAINDWGNIWLSETHGANLLSANAILSLFEMGGLLGALCSGWGSDLLFRGQRAPMILLFSLGLFIAVTALWLMPIHHYALLAACFFSIGFFVFGPQMLIGLAATEYCHKNAAGTVTGYLGLYAYLGAAIAGWPLSQVMAHYGWTGMFVLLTSAAALMGLLLMPLLIADVSKREHLVGPLSFSDDDTFKRF MNFLKPAKHIKPLPENQIDDTYKRLRLQVFLGIFIGYAGYYLLRKNFSLAMPALQEQGFTKAELGFALSAVSIAYGFSKFFMGTVSDRSNARIFLVLGLVLTAIVNLLMGFVPFFTSGIGIMFVLLFLNGWFQGMGWPPSGRVLVHWFSVSERGSKTALWNVAHNVGGGIMAPIAAWGITTTAFINFGYLKGFEGVFIYPALLALIIAAISYILIRDTPQSQGLPPIEIYKNDFATSDKKTLETELTTKEILFKYVLNNKWVWAIAFANIFVYFVRYGVLDWAPVYLSEEKHFDLKASGWAYFLYEWAGIPGTLLCGYISDKLFKGRRGPAGFFFMLGVTVFVLIYWLNPPGNAWLDNVSLIAIGFLIYGPVMLIGLQALDYVPKKAAGTAAGLTGLFGYLFGAVMANIVLGAVVDKFGWDVGFILLTAISVFAMLSFILTWNKVGQETVHH 98.45 gnl|BL_ORD_ID|2185|hsp_num:0 2380 Z1_00482 Glycerol-3-phosphate transporter Loose 850 821.6 Escherichia coli GlpT with mutation conferring resistance to fosfomycin 86.83 3003889 protein variant model E448K phosphonic acid antibiotic antibiotic target alteration antibiotic-resistant GlpT MLSLFRPAPHKARLPKEQIDPVYRRLRWQIFMGIFFGYAAYYLVRKNFALAMPYLVEEGFSKGDLGFALSGISIAYGFSKFIMGSFSDRANPRYFLPAGLILASIVMLIMGFVPWATSSIMIMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSIWNCAHNVGGGLPPLLFLLGMAWFNDWKAALYMPAFAAILVAMIAFALMRDTPQSCGLPPIEEYKNDYPPDYKETDEQELTAKEIFMKYVFPNKLLWMIAIANVFVYLLRYGVLDWSPTYLREVKDFAMDKSSWAYFLYEYAGIPGTLLCGWMSDKVFKGNRGATGVFFMTLVTIATIVFWMNPAGNPNIDMACMLIIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAASAIVGYTVDYFGWDGGFMVMIGGSVLSVVLLLIVMINETKHKREMSQKYE MLSIFKPAPHKARLPAAEIDPTYRRLRWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVPWATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFNDWHAALYMPAFCAILVALFAFAMMRDTPQSCGLPPIEEYKNDYPDDYNEKAEQELTAKQIFMQYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFRGNRGATGVFFMTLVTIATIVYWMNPAGNPTVDMICMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAASAIVGYTVDFFGWDGGFMVMIGGSILAVILLIVVMIGEKRRHEQLLQERNGG 99.56 gnl|BL_ORD_ID|2135|hsp_num:0 2372 Z1_00866 3-oxoacyl-[acyl-carrier-protein] reductase FabG Loose 450 66.6 Escherichia coli fabI mutations conferring resistance to isoniazid and triclosan 26.59 3004045 protein variant model F203L disinfecting agents and antiseptics; isoniazid-like antibiotic antibiotic target alteration antibiotic resistant fabI MFDLTGKIALVSGGAKGIGKGIVSALKNSGAQVIIADIDDVAGNATKQALGVDFMHLDVTSQAACEQVVNDIVKQYGKLDILCSNTGIFPQATIKEMTEADWDKMHTVNLKGMFFLVKAALAVMEKQQYGRVIITSSITGAITGYPGWSHYGASKAGQLGFMRSAALEYARHGITINAVMPGNILTEGLQAQGETYLNQMKASIPTHTLGEPEDIGYAAAFFASNEAKYITGQTIIVDGGQILPESPEALL MGFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMNELELK 95.80 gnl|BL_ORD_ID|4719|hsp_num:0 2666 Z1_00935 DNA gyrase subunit B Strict 1200 1374.4 Morganella morganii gyrB conferring resistance to fluoroquinolones 84.58 3003306 protein variant model S463A fluoroquinolone antibiotic antibiotic target alteration fluoroquinolone resistant gyrB MSNTYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGYCDEIIVTIHSDNSVSVRDDGRGIPTGIHEEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEKLELTIHRDGKIHQQIYRSGVPDDRLKVIGETDKSGTFVRFWPSLDTFKGETEFQYDILAKRLRELSFLNSGVSIRLIDKRDNREDHFHYEGGIKAFVEYLSRNKTPIHQNVFYFSTEKDGIGVEVAMLWNDGFQENVYCFTNNIPQRDGGTHLVGFRTAMTRTLNNYMDKEGFNKKSKISATGDDAREGLIAVISVKVPDPKFSSQTKDKLVSSEVKTAVETLMNEKLVEYLLENPTDAKIVVGKIIDAARAREAARKAREMTRRKGALDLGGLPGKLADCSERDPAFSELYLVEGDSAGGSAKQGRNRKTQAILPLKGKILNVEKARFDKMLASQEVATLITALGCGIGRDEYNPDKLRYHSIIIMTDADVDGSHIRTLLLTFFYRQMPEIIERGHIFIAQPPLYKVKKGKQEQYIKDDDAMDEYLMSIALDGAALYVSEHAPAMHGAQLEKLVVDYHAAHKIIRRMERLYPLSMLNSLVYHSTLTEDDLSDKAKVEEWMSGLVNRLNNAEEQSSTYSYTITQNEENRLFEPVLRIRTYGIDTDYKLDYDFIHSSEYQRITNLGDIIGNLIEEGAYIERGERRQAISSFEEALEWLTKESRRGLAVQRYKGLGEMNPEQLWETTMNPDTRRMMQVTVKDAIATDELFTTLMGDAVEPRRAFIEENALKAENIDI MSNTYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGYCKDIIVTIHNDNSVSVQDDGRGIPTGIHEEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEKLELVIRRDGKVHEQIYRHGEPQDRLTVVGETDKTGTRVRFWPSMDTFKGETEFQYDILAKRLRELSFLNSGVSIRLIDKRDGKEDHFHYEGGIKAFVEYLSRAKTSIHNNVFYFSTEKDDIGVEISMQWNDSFQENVYCFTNNIPQRDGGAHLAGFRAAMTRTLNSYIEKEGLNKKSKVSTTGDDAREGLVAVISVKVPDPKFSSQTKDKLVSSEVKTAVETLMNEKLSEYLDENPNDTKIIVGKIIDAARAREAARRAREMTRRKGALDLAGLPGKLADCQERDPAFSELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLASQEVATLITALGCGIGRDEYNPDKLRYHSIIIMTDADVDGSHIRTLLLTFFYRQMPEIIERGYVYIAQPPLYKVKKGKQEQYIKDDEAMEQYQVSIALDGAALYVNENAAPIQGEHLEKLLHEYNGAHKIIRRLERLYPLALLNSLVYQPKLEESALLNKTEVEAWAQSLTERLTRHEEHGSTYSYRIAENKERQLFEPVLTIRTHGVDTDYNLDFDFVHGSEYARISKLGELIRGLIEEGAYVVRGERRQNVSNFEQALDWLMKESRRGLAVQRYKGLGEMNPEQLWETTMNPETRRMLQVTVKDAIATDQLFTTLMGDDVEPRRAFIEENALKAANIDV 100.00 gnl|BL_ORD_ID|1999|hsp_num:0 535 Z1_01021 Ribosomal RNA small subunit methyltransferase G Loose 400 84.0 Mycobacterium tuberculosis gidB mutation conferring resistance to streptomycin 34.75 3003470 protein variant model Q127P aminoglycoside antibiotic antibiotic target alteration antibiotic resistant gidB MSDLLNRLKKLAKQANIELTDVQAQKLTAYVAMLDKWNKAYNLTSVRDPQQMLIRHILDSIVVSQYLEGNNFIDVGTGPGLPGIPLAIMRPDHHFVLLDSLGKRVRFMKQVQHELALHNIEPVQYRVEEYQVEKPFDGVISRAFASMKDMLSWCSHLVTEEHGRFYALKGQIHQEELDELSENGLKMPEKVINLAIPELNEQRHLVIF MSPIEPAASAIFGPRLGLARRYAEALAGPGVERGLVGPREVGRLWDRHLLNCAVIGELLERGDRVVDIGSGAGLPGVPLAIARPDLQVVLLEPLLRRTEFLREMVTDLGVAVEIVRGRAEESWVQDQLGGSDAAVSRAVAALDKLTKWSMPLIRPNGRMLAIKGERAHDEVREHRRVMIASGAVDVRVVTCGANYLRPPATVVFARRGKQIARGSARMASGGTA 92.86 gnl|BL_ORD_ID|1937|hsp_num:0 489 Z1_01347 DNA-directed RNA polymerase subunit beta' Loose 3000 1075.5 Helicobacter pylori rpoB mutation conferring resistance to rifampicin 54.37 3007051 protein variant model K2068R fluoroquinolone antibiotic; rifamycin antibiotic antibiotic target alteration; antibiotic target replacement rifamycin-resistant beta-subunit of RNA polymerase (rpoB) MKDLLKFLKAQTKTEEFDAIKIALASPDMIRSWSFGEVKKPETINYRTFKPERDGLFCARIFGPVKDYECLCGKYKRLKHRGVICEKCGVEVTQTKVRRERMGHIELASPVAHIWFLKSLPSRIGLLLDMPLRDIERVLYFESYVVVEGGMTSLERGQILTEEQYLDALEEFGDEFDAKMGAEAVQNLLQSMDLEQECETLREELNETNSETKRKKLTKRIKLLEAFMQSGNKPEWMILTVLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLDLAAPDIIVRNEKRMLQESVDALLDNGRRGRAITGSNKRPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVITVGPYLRLHQCGLPKKMALELFKPFIYGKLETRGLATTIKAAKKMVEREEAVVWDILDEVIREHPVMLNRAPTLHRLGIQAFEPILIEGKAIQLHPLVCAAYNADFDGDQMAVHVPLTLEAQLEARALMMSTNNILSPASGDPIIVPSQDVVLGLYYMTRDCINAKGEGMVLSGPKEAERVYRAGLASLHARVKVRITEEIKDGEGNITTETSLKDTTVGRAILWMIVPKGLPYALVNQPLGKKAISKMLNTCYRVMGLKPTVIFADQIMYTGFAYAARSGASVGIDDMVIPAKKAEIIAEAEAEVAEIQEQFQSGLVTAGERYNKVIDIWAAANERVAKAMMENLSTETVINRDGEEEQQVSFNSIFMMADSGARGSAAQIRQLAGMRGLMAKPDGSIIETPITANFREGLNVLQYFISTHGARKGLADTALKTANSGYLTRRLVDVAQDLVVTESDCGTTEGVMMTPVIEGGDVKEPLRERVLGRVTAEDILKPGTADILVPRNTLLNEKLCDLLEENSVDSVKVRSVVTCDTDFGVCAKCYGRDLARGHIINKGEAIGVIAAQSIGEPGTQLTMRTFHIGGAASRAAAESSIQVRNKGTLKLINAKFITNTAGKLVITSRNTELRLIDEFGRTKESYKVPYGAQLSKGDGEAVNGGETVANWDPHTMPVVSEVSGIIRFADMVDGQTITRQTDELTGLSSLVVLDTAERTGSGKDLRPALRITDAQGNDVLIPNTDMPAQYFLPGKAIVQLDDGVAINAGDTLARIPQESGGTKDITGGLPRVADLFEARRPKEPAILAEISGIVSFGKETKGKRRLVISPLDGSDAYEEMIPKWRQLNVFEGEVVERGDVISDGPESPHDILRLRGVHAVTRYITNEVQEVYRLQGVKINDKHIEVIVRQMLRKVTIENAGSSEFLEGEQVEYARVKVSNRILEEEGKVPATYSRDLLGITKASLATESFISAASFQETTRVLTEAAVAGKRDELRGLKENVIVGRLIPAGTGFAYHQDRIQRRQQQLPTDETEATISADEASANLAELLNAGFGGSSNN MSKKIPLKNRLRADFTKTPTDLEVPNLLLLQRDSYDSFLYSKEGKESGIEKVFKSIFPIQDEHNRITLEYAGCEFGKSKYTVREAMERGITYSIPLKIKVRLILWEKDTKSGEKNGIKDIKEQSIFIREIPLMTERTSFIINGVERVVVNQLHRSPGVIFKEEESSTSLNKLIYTGQIIPDRGSWLYFEYDSKDVLYARINKRRKVPVTILFRAMDYQKQDIIKMFYPLVKVRYENDKYLIPFASLDANQRMEFDLKDPQGKVILLAGKKLTSRKIKELKENHLEWVEYPMDILLNRHLAEPVMVGKEVLLDMLTQLDKNKLEKIHDLGVQEFVIINDLALGHDASIIQSFSADSESLKLLKQTEKIDDENALAAIRIHKVMKPGDPVTTEVAKQFVKKLFFDPERYDLTMVGRMKMNHKLGLHVPDYITTLTHEDIITTVKYLMKIKNNQGKIDDRDHLGNRRIRAVGELLANELHSGLVKMQKTIKDKLTTMSGAFDSLMPHDLVNSKMITSTIMEFFMGGQLSQFMDQTNPLSEVTHKRRLSALGEGGLVKDRVGFEARDVHPTHYGRICPIETPEGQNIGLINTLSTFTRVNDLGFIEAPYKKVVDGKVVGETIYLTAIQEDSHIIAPASTPIDEEGNILGDLIETRVEGEIVLNEKSKVTLMDLSSSMLVGVAASLIPFLEHDDANRALMGTNMQRQAVPLLRSDAPIVGTGIEKIIARDSWGAIKANRAGVVEKIDSKNIYILGESKEEAYIDAYSLQKNLRTNQNTSFNQVPIVKVGDKVGAGQIIADGPSMDRGELALGKNVRVAFMPWNGYNFEDAIVVSECITKDDIFTSTHIYEKEVDARELKHGVEEFTADIPDVKEEALAHLDESGIVKVGTYVSAGMILVGKTSPKGEIKSTPEERLLRAIFGDKAGHVVNKSLYCPPSLEGTVIDVKVFTKKGYEKDARVLSAYEEEKAKLDMEHFDRLTMLNREELLRVSSLLSQAILEEPFSHNGKDYKEGDQIPKEEIASINRFTLASLVKKYSKEVQNHYEITKNNFLEQKKVLGEEHEEKLSILEKDDILPNGVIKKVKLYIATKRKLKVGDKMAGRHGNKGIVSNIVPVADMPYTADGEPVDIVLNPLGVPSRMNIGQILEMHLGLVGKEFGKQIARMLEDKTKDFAKELRAKMLEIANAINEKDPLTIHALENCSDEELLEYAKDWSKGVKMAIPVFEGISQEKFYKLFELAKIAMDGKMDLYDGRTGEKMRERVNVGYMYMIKLHHLVDEKVHARSTGPYSLVTHQPVGGKALFGGQRFGEMEVWALEAYGAAHTLKEMLTIKSDDIRGRENAYRAIAKGEQVGESEIPETFYVLTKELQSLALDINIFGDDVDEDGAPKPIVIKEDDRPKDFSSFQLTLASPEKIHSWSYGEVKKPETINYRTLKPERDGLFCMKIFGPTKDYECLCGKYKKPRFKDIGTCEKCGVAITHSKVRRFRMGHIELATPVAHIWYVNSLPSRIGTLLGVKMKDLERVLYYEAYIVKEPGEAAYDNEGTKLVMKYDILNEEQYQNISRRYEDRGFVAQMGGEAIKDLLEEIDLITLLQSLKEEVKDTNSDAKKKKLIKRLKVVESFLNSGNRPEWMMLTVLPVLPPDLRPLVALDGGKFAVSDVNELYRRVINRNQRLKRLMELGAPEIIVRNEKRMLQEAVDVLFDNGRSTNAVKGANKRPLKSLSEIIKGKQGRFRQNLLGKRVDFSGRSVIVVGPNLKMDECGLPKNMALELFKPHLLSKLEERGYATTLKQAKRMIEQKSNEVWECLQEITEGYPVLLNRAPTLHKQSIQAFHPKLIDGKAIQLHPLVCSAFNADFDGDQMAVHVPLSQEAIAECKVLMLSSMNILLPASGKAVAIPSQDMVLGLYYLSLEKSGVKGEHKLFSSVNEIITAIDTKELDIHAKIRVLDQGNIIATSAGRMIIKSILPDFIPTDLWNRPMKKKDIGVLVDYVHKVGGIGITATFLDNLKTLGFRYATKAGISISMEDIITPKDKQKMVEKAKVEVKKIQQQYDQGLLTDQERYNKIIDTWTEVNDKMSKEMMTAIAQDKEGFNSIYMMADSGARGSAAQIRQLSAMRGLMTKPDGSIIETPIISNFKEGLNVLEYFNSTHGARKGLADTALKTANAGYLTRKLIDVSQNVKVVSDDCGTHEGIEITDIAVGSELIEPLEERIFGRVLLEDVIDPITNEILLYADTLIDEEGAKKVVEAGIKSITIRTPVTCKAPKGVCAKCYGLNLGEGKMSYPGEAVGVVAAQSIGEPGTQLTLRTFHVGGTASRSQDEREIVASKEGFVRFYNLRTYTNKEGKNIIANRRNASILVVEPKIKAPFDGELRIETVYEEVVVSVKNGDQEAKFVLRRSDIVKPSELAGVGGKIEGKVYLPYASGHKVHKGGSIADIIQEGWNVPNRIPYASELLVKDNDPIAQDVYAKEKGVIKYYVLEANHLERTHGIKKGDMVSEKGLFAVIADDNGREAARHYIARGSEILIDDNSEVSTNSVISKPTTNTFKTIATWDPYNTPIIADFKGKVGFVDVIAGVTVAEKEDENTGITSLVVNDYIPSGYKPSLFLEGANGEEMRYFLEPKTSIAISDGSSVEQAEVLAKIPKATVKSRDITGGLPRVSELFEARKPKPKDVAILSEVDGIVSFGKPIRNKEHIIVTSKDGRSMDYFVDKGKQILVHADEFVHAGEAMTDGVISSHDILRISGEKELYKYIVSEVQQVYRRQGVSIADKHIEIIVSQMLRQVRILDSGDSKFIEGDLVSKKLFKEENARVIALKGEPAIAEPVLLGITRAAIGSDSIISAASFQETTKVLTEASIAMKKDFLEDLKENVVLGRMIPVGTGMYKNKKIVLRALEDNSKF 48.75 gnl|BL_ORD_ID|4773|hsp_num:0 5750 Z1_01724 DNA topoisomerase 4 subunit B Loose 1000 444.5 Clostridioides difficile gyrB conferring resistance to fluoroquinolones 38.99 3004562 protein variant model V423F, I139R S463A:535 fluoroquinolone antibiotic antibiotic target alteration fluoroquinolone resistant gyrB MTQSSYNAKDIEVLNGLEPVRRRPGMYTDTTRPNHLAQEVIDNSVDEALAGHATKVEVILYADQSIEVIDNGRGMPVDIHPELKVSAIELILAHLHAGGKFSNKNYQYSGGLHGVGISVVNALSKRIEVTVRREGKIYQIAFENGDKVEELHQIGTCAKRDTGTSVHFWPDSTYFDIPRFSSKSLSHVLKAKAVLCPGVNVSFTDKVNNTQETWCYADGLTDYLSEAVAEFVRLPEEPFTGKFEGDNEAVEWSMLWLPEGGDLLTESYVNLIPTVQGGTHVNGLRQGVLDAMREFCEFHNLLPRGIKLTADDTWERCAYVLSVKMQDPQFAGQTKERLSSRQTSAFVASAVKNAFSLWLNQNVQVGELLAEMAISSAQRRMRAAKKVVRKKLTSGPALPGKLADCTSQDLRYTELFLVEGDSAGGSAKQARDREYQAIMPLRGKILNTWEVSSDEVLASQEVHDISVAIGMDPDSDDLSQLRYGKICILADADSDGLHIATLLCALFVRHFTALVKQGHVYMAMPPLYRIDLGKEVSYALDEAEKNAILQRLSRKKGKPNVQRFKGLGEMNPLQLRETTLDPNTRRLVQLVIDDENYQETLGMMDMLLAKKRSEDRRNWLQEKGDEVDIEV MMQEKKQTYDENQIQVLEGLEAVRKRPGMYIGSTSSRGLHHLVYEIVDNSIDEALAGYCDKINVIIHKDNSITVTDNGRGMPVGMHHKMKKPTVEVIMTILHAGGKFGGGGYKVSGGLHGVGASVVNALSEICEVEVKRESHIWRQVFKRGKVASGLDIIGDSEEHGTKIHFKPDAEIFDEIEYDYDTLAQRLRELAFLNKGIKIRLEDERDDKEEIFHYEGGIKSFVTYLNRNKQPIHKEPIYVEGKKDDYSVEIAIQYNDGYTENIFAFANNIDTVEGGTHLAGFKSALTRVFNDYAKKFGILKENDKNLSGEDIREGLTAVISVKLVDPQFEGQTKTKLGNSEVRGIVDSIMGESLNNFLQENPQVAKMILDKSLMASRAREAARKARELTRRKSILENTSLPGKLADCSSKDPSECEIYLVEGDSAGGSAKQGRNRKFQAILPLRGKIMNVEKQRLDKILGYEEIRAMITAFGAGIGKDFDVNKIRYNKIIIMTDADVDGAHIRTLLLTFFFRYMKELVEKCHVYIAQPPLYRVAKGKKEYYAYSDDELDVLLTEIGGKDSNVDIQRYKGLGEMDSEQLWDTTMNPETRTLIQVNVEDTMAADEIFTILMGDKVEPRRNFIQENAKKVVNLDI 99.06 gnl|BL_ORD_ID|4729|hsp_num:0 3268 Z1_01725 DNA topoisomerase 4 subunit A Loose 1400 771.2 Acinetobacter baumannii parC conferring resistance to fluoroquinolones 56.55 3003818 protein variant model V104I S87R:2405 fluoroquinolone antibiotic antibiotic target alteration fluoroquinolone resistant parC MSELTHDGVERQPLHLFTENAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNSSAKFKKSARTVGDVLGKYHPHGDRACYEAMVLMAQPFSYRYPLIDGQGNWGTPDDPKSFAAMRYTESRLSKYSQILLSELGHGTVDWIPNFDGTLQEPKMLPARLPNILLNGTTGIAVGMATDIPPHNAREIGQALTMLLDNPDAGLSDVMQYVQGPDYPTEAEVITAPEDIKKIYKTGRGSIRMRAVWQKEEGCAVITALPHQVSGAKVLEQIAALMRAKKLPLVDDLRDESDHENPTRLVIVPRSNRVDLEQVMYYLFVNTDLEKSYRVNLNMIGLDNRPAVKGLLTILNEWLVYRRQTVTNRLNHRLEKVLRRLEILKGLLIAYLNIDEVIEIIRYEDEPKAELMRRFALSDIQAEAILELRLRHLAKLEEIKLQAESDELEKERDSIEKLLNSPRRLNTLLKKEIEADAKEFGDERRSPIRPQEEAKVVNEQDMLPSEPVTIVLSEMGWVRSAKGHEIDPSTMSYRAGDSYHSAVRGMSNQPVLFLDSTGRSYSLSPNDMPSGRSQGEPLTGKLTFPPDASVKYMLAGAAKQEYLLATKEGYGSVLSYEEMETKNKTGKGLLTVSDETELLAPFLVDAEKKNNQHWLVIITDKTRILAISAEHLNEMNKKGRGTRLVALGKEQSDVIEQIVLIAKNEALTFTVDGQQQTLKAEEISYFSGDVGDEPIPLKHLHPEAVTVIMSEKGLIRCQKGHNIDAKSVGFKTGDDYFDAVEGMSNQAVHLIDTTGQSYTVDVDALPSGRSKGDDLTGRLKVQKGAQLRHVVMGESSDKILMASDAGYGFICSIDDLTSKNRAGKSLLTLPENALPLPPQRLNDELSDLIMIITQGGRMLIFEASELPTMVKGKGNQMVSIPASQAASGEDKVAWLRVLPENASVTLHFGKRKLTMSMNELQTFKAKRGRRGTSLPRGAQSIDHIDIETH MTSLAHHATENRSVAEFTEQAYLNYAMYVIMDRALPHISDGLKPVQRRIVYAMSELGLKSSGKPKKSARTVGDVLGKYHPHGDLACYEAMVLMAQPFSYRYPLIEGQGNWGSPDDPKSFAAMRYTEAKLSAYSELLLSELGQGTSEWQDNFDGSLKEPITLPARVPNILLNGTTGIAVGMATDIPPHNLREVVKGTIALIRNPQTSDEKLAEYIPAPDLPTKAEIITPPEELLKIQTTGRGSYRMRAVYTIEKNEIVITELPYQVSGSKVITQIADQMQAKKLPLVVDVRDESDHENPTRLVIVLRSNRIDAEAVMSHLFATTDLESSYRVNLNMIGEDGRPQVKSIRRILLEWIEIRKKTVTRRLQYHLNRIEKRLHILAGLLIAYLDIDTVIRIIREEDQPKPVLMEHFNIDEIQAEAILELKLRHLAKLEEMEIRHEQDELSAKAAIIREQLENPESLKNLIIGELKEDAKKFGDERRSPIVARAEAVQIKEQDLMPAETVTVVLSEAGWVRAAKGADVDAENLNYRAGDQYLSHAVGKTNQRVYFLDETGRSYALPISNLPSARGLGDPLSSKLSPASGVSFIQVYLDDDESELIAASSAGYGFKTQTKQLDTNAKAGKTFLTVPDKAKALPLISAQNMTHLAVLSSAGRLLILDLAELPNLNKGKGNKLIQLEGKEQILSMTTLNLDEIIQVVAGQQHLKLKGDDLQKYMGKRASKGQLLPRGYQKANKLLIQR 133.29 gnl|BL_ORD_ID|2117|hsp_num:0 2315 Z1_02266 Penicillin-binding protein 1C Loose 1300 187.6 Helicobacter pylori pbp1 mutants conferring resistance to amoxicillin 26.61 3007060 protein variant model N562Y, A201V cephalosporin; cephamycin; penam antibiotic target alteration Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics MKLGYKRLIAASVIFLLVTPLLLWIADKIWPLPDPEPQIATIVTAEDGTPLWRFADKEGIWRYHVTLSDVSPEYLQALIAYEDRWFYQHPGVNPIAILRAAWQDLSSGKIVSGGSTLSMQVARLIDPHSRTLGGKLKQLWRTLQLEWYYSKDEILEIYLNRAPFGGTLEGIGAASWAYLGKSPADLSAGEATLMAVLPQAPSRLRPDRYPERAQAARDKVLDRLAEYQIWPKEKVAEIKQEQVLLAPRQTPQLAPLLARRMYNEQKAPVITTTIDINLQRQLEELAKQWKYQLADKTSLAILVVDHTDMSVKGYVGSADFNDNQRFGHVDMISAWRSPGSTLKPFIYGLALDEGLIHAESLLQDVPRRFEDYRPGNFDTGFNGAVSASEALSRSLNLPAVQLIEAYGAKKFAAKLRHNHLEMRFPYGSEPNLALILGGTATRMDQLVATFSALARHGKTAPLRFTPEQTINERMLMSPGAAWIIRRILAGEARPRPDSAISAVVPLAWKTGTSYGYRDAWSIGVNARYTIGVWVGRPDGTPVAGQFGFATAVPIMNQVNNLLTSYFYQNKQRPPVDPRPNSVSAAAICWPTGKALPKEDSNCRVSRRSWILDNTIPPTLLNESQEGILGINEKVWIDKEGKRTGPNCPGAQLKDIALWPIALDAWLPEKERRAKRLPPISLTCPPIKEDMIPLYISGIRKGDLLRPLPGETQLEITVSTQGGSGMQWWFLNGEQIGKTENGATFSYLLEKRGKYQLSVLDLSGQTDMVNFSFR MLKKIFYGFIVLFLIIVGLLAILIAQVWVTTDKDIAKIKDYRPGVASQILDRKGRLIANIYDKEFRFYARFEEIPPRFIESLLAVEDTLFFEHGGINLDAIMRAMIKNAKSGRYTEGGSTLTQQLVKNMVLTREKTLTRKLKEAIISIRIEKVLSKEEILERYLNQTFFGHGYYGVKTASLGYFKKPLDKLTLKEIAMLVALPRAPSFYDPTKNLEFSLSRANDILRRLYSLGWISSNELKSALNEVPIVYNQTSTQNIAPYVVDEVLKQLDQLDGLKTQGYIIKLTIDLDYQRLALESLRFGHQKILEKIAKEKPKTNASNEDEDNLNASMIVTDTSTGKILALVGGIDYKKSAFNRATQAKRQFGSAIKPFVYQIAFDNGYSTTSKIPDTARNFENGNYSKNSKQNHAWHPSNYSRKFLGLVTLQEALSHSLNLATINLSDQLGFEKIYQSLSDMGFKNLPKDLSIVLGSFAISPIEAAEKYSLFSNYGTMLKPMLIESITNQQNDVKTFTPMETKKITSKEQAFLTISVLMNAVENGTGSLAHIKGLEVAGKTGTSNNNIDAWFIGFTPTLQSVIWFGRDDNTPISKGATGGVVSAPVYSYFMRNILSIEPSLKRKFDVPKGLRKEIVDKIPYYSTPNSITPTPKRTDDSEERLLF 117.30 gnl|BL_ORD_ID|4768|hsp_num:0 5758 Z1_02391 DNA gyrase subunit A Loose 1500 1375.1 Escherichia coli gyrA conferring resistance to fluoroquinolones 80.71 3003294 protein variant model S83I T83I:3656, T83I:2196, T82I:2550, P116A:2550, T87I:5752, N87I:5752, T86I:2294, M95I:3330, S80I:1450, A85T:2412, S91I:2083 fluoroquinolone antibiotic antibiotic target alteration fluoroquinolone resistant gyrA MSDIAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMNVLGNDWNKPYKKSARVVGDVIGKYHPHGDIAVYETIVRLAQPFSMRYMLVDGQGNFGSVDGDSAAAMRYTEVRMAKIAHELLADLEKETVDFVPNYDGTENIPAVMPTRIPNLLVNGSSGIAVGMATNIPPHNLGEVIDGCLAYVDNEDITIEELMEYITGPDFPTAAIINGRRGILDAYRTGRGKIYIRAQADIETDEKTGRETIIVTEIPYQVNKARLIEKIAELVKDKRIEGISGLRDESDKDGMRIVVEIKRDAVGEVVLNHLFSQTQMQVSFGINMVALHQGQPKLLNLKEIIAAFIRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPVIELIRQAPTPAEAKAALIAQPWDLGSVSAMLERAGDSNVARPEWLEPQFGVHDGKYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYRELLLQIAELLHILRSPERLMDVIREELTAIKTQYNDPRRTEITENTADINIEDLINEENVVVTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIINLLPLEQDERITAILPVREYEEGKFVFMATASGTVKKTPLQDFSRPRSAGIIAVNLNDGDELIGVDLTDGSNEAMLFSADGKVVRFAEECVRPMGRTATGVRGMKLVDDDKVVSLIIPRGEGDILTVTENGYGKRTVQSEYPTKNRATQGVISIKVSERNGKVVGAIQVEETDQIMMITNAGTLVRTRVSEVSIVGRNTQGVTLIRTTEDELVVGLQRVEDEDDALDDDEVDEMISDNISDVPESEPTDDADSEEE MSDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTEKIPDVMPTKIPNLLVNGSSGIAVGMATNIPPHNLTEVINGCLAYIDDEDISIEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEVDAKTGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRHAPTPAEAKTALVANPWQLGNVAAMLERAGDDAARPEWLEPEFGVRDGLYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLDQIAELLRILGSADRLMEVIREELELVREQFGDKRRTEITANSADINLEDLITQEDVVVTLSHQGYVKYQPLSEYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDHILCFSSRGRVYSMKVYQLPEATRGARGRPIVNLLPLEQDERITAILPVTEFEEGVKVFMATANGTVKKTVLTEFNRLRTAGKVAIKLVDGDELIGVDLTSGEDEVMLFSAEGKVVRFKESSVRAMGCNTTGVRGIRLGEGDKVVSLIVPRGDGAILTATQNGYGKRTAVAEYPTKSRATKGVISIKVTERNGLVVGAVQVDDCDQIMMITDAGTLVRTRVSEISIVGRNTQGVILIRTAEDENVVGLQRVAEPVDEEDLDTIDGSAAEGDDEIAPEVDVDDEPEEE 100.23 gnl|BL_ORD_ID|1975|hsp_num:0 1545 Z1_02635 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase Loose 300 86.7 Staphylococcus aureus pgsA mutations conferring resistance to daptomycin 35.68 3003323 protein variant model K66R peptide antibiotic antibiotic target alteration daptomycin resistant pgsA MQLNIPTWLTLFRVALIPFFVLVFYLPFKDAPLICAIIFMVAAATDWFDGFLARRWKQTTRFGAFLDPVADKVMVATALVLITEHYHVWWITLPAATMIAREIIISSLREWMAELGKRNSVAVSWIGKVKTTAQMGALVVLLWRPTIEAEWFGFVLLYIATVLTFWSMFQYLSAAWSDLREA MNIPNQITVFRVVLIPVFILFALVDFGFGNVSFLGGYEIRIELLISGFIFILASLSDFVDGYLARKWNLVTNMGKFLDPLADKLLVASALIVLVQLGLTNSVVAIIIIAREFAVTGLRLLQIEQGFVSAAGQLGKIKTAVTMVAITWLLLGDPLATLIGLSLGQILLYIGVIFTILSGIEYFYKGRDVFKQK 94.79 gnl|BL_ORD_ID|1936|hsp_num:0 462 Z1_02659 Nicotinamidase Loose 300 102.1 Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide 34.15 3003394 protein variant model N118T, T47S, F58L pyrazine antibiotic antibiotic target alteration Pyrazinamide resistant pncA MKNSALLLVDLQNDFCTGGALAVKESDTVIDTANRLIDYFQRHQRPIIASKDWHPADHLSFAKNSGTVVGEIGQLNGRPQVWWPVHCVQNSHGADFHPLLTDDLISHIIYKGQNRLIDSYSAFFDNDHEYQTGLHTLLQSMQIEHLTILGIATDYCVKFTVLDALQLGYQVSVVMDGCRGVNIQPDDSQLAFNQMQQHGAVLVDSVTMLKSDK MRALIIVDVQNDFCEGGSLAVTGGAALARAISDYLAEAADYHHVVATKDFHIDPGDHFSGTPDYSSSWPPHCVSGTPGADFHPSLDTSAIEAVFYKGAYTGAYSGFEGVDENGTPLLNWLRQRGVDEVDVVGIATDHCVRQTAEDAVRNGLATRVLVDLTAGVSADTTVAALEEMRTASVELVCSS 114.52 gnl|BL_ORD_ID|1948|hsp_num:0 851 Z1_02809 Cardiolipin synthase A Loose 900 186.8 Enterococcus faecium cls conferring resistance to daptomycin 27.67 3003092 protein variant model H215R H215R:2272 peptide antibiotic antibiotic target alteration daptomycin resistant cls MTTFYTVLSWLTFFFYWLLIAGVTFRVLMHRRPVTSTMTWLLIIYILPLVGVIAYFAFGELHLGKRRVEHARQMWPSVVAWLEELKKCKHIFAKHYSDVAEPIFQLTAKRQGINGVKGNKIQLLTTCEDSLNAITRDINNARDNIEMVFYIWQSGGLVEEVTEALIQAAKRGVKCRIMVDSAGSRSFFRTNGPARMRAAGIEFVESLQVNLFRFFLRRMDLRQHRKIVLIDNYISYTGSMNMVDPRYFKQDAGVGQWIDIMVRMEGPVSTTLGIIYAFDWEMETGERHLPPPPDNNIMPFEQANGHTTQVIASGPGFPEELIQQSLITAIYSARKELVMTTPYFVPSDDLAHAISTAAMRGVDVSIIVPRSNDSFLVRWASRAFFTEILEAGVKVFQFEDGLLHTKSVMVDGQLSMVGSVNLDMRSLWLNFEITVVIDDECFASDLSIVQYDYIARSTQLTLDEWEKRPFMNRVLERLCYFFSPLL MVSSIITALYLLNALIALVAILIKPRDVAAIWAWLLVLFALPGVGFVLYLFFGRGLTDKKKFYLRQSDLKELENFQSFRGDTIEHYDPDMGDKDKQQFVDFFSSLNRMPLTRMNSVTLLTDGQEKLDSLLQDLKKAKHSIHIEYYAFVTDNIGQQVLHVLEEKAAEGVEVRILYDAFGSHGTKAKDFNRLIKNGGHVHTFVTSQRALLRFRLNYHDHRKIVVIDGKISYTGGFNIANQYVNTTKKFGYWRDTHIRIFGAASSLLQLRFLTDWNVSVPEEKKVGYHLNYFFKKADRDESKLADTSIQLVSSGPNNEREQIKLSFIKLITSAKKRVWIQTPYLVPDESVIAALKIATASGVDVKIMIPNKPDHPFIYRATQYYARQLIKENVQILVYENGFLHAKTLIMDDEICMVGSANQDIRSYRLNFETSAVIYDPEFLEELATQFKEDETHCSSMTTETVKEMSNWLLFKQQISRLFSPIL 100.62 gnl|BL_ORD_ID|1953|hsp_num:0 1175 Z1_03235 NADH dehydrogenase Loose 800 147.5 Mycobacterium tuberculosis ndh with mutation conferring resistance to isoniazid 27.34 3003461 protein variant model R268H isoniazid-like antibiotic antibiotic target alteration antibiotic resistant ndh MSLTKIVIVGGGAGGLELATKLGDKLGRKKKAEITLVDRNNSHLWKPLLHEVATGSLDDGVDALSYLAHGYNHHFNFQLGTLTGLDRQHKNITLAAIYDENQELLVPERQLDYDILVMALGSKSNDFGTPGIKEHCIFLDSPQQAHRFHNEMLNLFLKYSADSNAEAENRKVNIAIVGGGATGVELSAELHNAVRQLNSYGLKKLAPSALNITLVEAGERILPALPVRISSAAHQELTKLGVRVMTKTMVTSADEKGLNTKDGEHIDADLMVWAAGIKAPDFMKDIAGLETNRINQLVVKPTLQTTLDDAIFAIGDCASCPRKEGGFVPPRAQSAHQMASRCYSNILAMLKGKTLKEYVFKDHGSLVSLSKFSTVGSLMGNLMKGDMMIEGRIARIVYISLYRMHQIALHGYLKTGLMMLVGSINRVIRPKLKLH MSPQQEPTAQPPRRHRVVIIGSGFGGLNAAKKLKRADVDIKLIARTTHHLFQPLLYQVATGIISEGEIAPPTRVVLRKQRNVQVLLGNVTHIDLAGQCVVSELLGHTYQTPYDSLIVAAGAGQSYFGNDHFAEFAPGMKSIDDALELRGRILSAFEQAERSSDPERRAKLLTFTVVGAGPTGVEMAGQIAELAEHTLKGAFRHIDSTKARVILLDAAPAVLPPMGAKLGQRAAARLQKLGVEIQLGAMVTDVDRNGITVKDSDGTVRRIESACKVWSAGVSASRLGRDLAEQSRVELDRAGRVQVLPDLSIPGYPNVFVVGDMAAVEGVPGVAQGAIQGAKYVASTIKAELAGANPAEREPFQYFDKGSMATVSRFSAVAKIGPVEFSGFIAWLIWLVLHLAYLIGFKTKITTLLSWTVTFLSTRRGQLTITDQQAFARTRLEQLAELAAEAQGSAASAKVAS 93.95 gnl|BL_ORD_ID|1993|hsp_num:0 1203 Z1_01105 Tetracycline repressor protein class A from transposon 1721 Loose 400 204.5 tetR 52.74 3003479 protein overexpression model n/a n/a tetracycline antibiotic antibiotic target alteration; antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MFISDKVSSMTKLQPNTVIRAALDLLNEVGVDGLTTRKLAERLGVQQPALYWHFRNKRALLDALAEAMLAENHTHSVPRADDDWRSFLIGNARSFRQALLAYRDGARIHAGTRPGAPQMETADAQLRFLCEAGFSAGDAVNALMTISYFTVGAVLEEQAGDSDAGERGGTVEQAPLSPLLRAAIDAFDEAGPDAAFEQGLAVIVDGLAKRRLVVRNVEGPRKGDD MMSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS 108.17 gnl|BL_ORD_ID|443|hsp_num:0 276 Z1_01178 HTH-type transcriptional regulator ChbR Loose 200 44.3 Escherichia coli soxS with mutation conferring antibiotic resistance 28.83 3003511 protein overexpression model n/a n/a fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics antibiotic target alteration; antibiotic efflux; reduced permeability to antibiotic ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams MMMHSLKAQAEIRMVYENQLFNGKNFHVFIYNKTESVSGLHQHDYYEFTIVLTGRYYQEINGKKVLLERGDFVFIPIGSHHQSFYDFGVTRILNVGISKAFFDKHYLPLLPAYFVASQVYALKNEFLSYIESVISSLNFRHTEFNEFIEIVTFNVVNRLRHYRDDRIEDDIPLWLKDAIDGMHDKSRFGENALANMVQLSGKSQEYLTRATRRYYDKTPMQIIHDIRINFAKKQLEITNYSVTDIAFDAGYSSPSLFIKTFKKITSLTPNSYRKNLYSIKETN MSHQKIIQDLIAWIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGYVSQQTFSRVFRRQFDRTPSDYRHRL 264.49 gnl|BL_ORD_ID|1978|hsp_num:0 2066 Z1_01396 Quinone oxidoreductase 1 Loose 660 93.6 MexS 32.67 3000813 protein overexpression model n/a n/a fluoroquinolone antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MAKRIQFAAHGNADVLELTSFTPAPLGDNEVQVANKAIGINYIDTYVRSGLYPVEHFPSGLGTEAAGVVIKTGAHVTSLKEGDRVVYAQSPLGAYSDTHNVPENKVARLPDNISFEQAAASFLKGLTVYYLFNETYKLRAGETFLFHAAAGGVGLIASQWAKAIGAKMIGTAGSDEKVAKAKAAGAWKVINYQTESIVERVLALTNNQKVPVVYDSVGKATWLDSLHCLQRRGLMVSFGNASGAVTGVDLGILNKLGSLYVTRPSISGYITTREELDAASEALFTLIGRGKIDVSVPDNQKFALADAKAAHRYLESRQSQGSSLLIP MSRVIRFHQFGPPEVLKCEELPTPAPAAGEVLVRVQAIGVSWKDVLWRQNLAPEQAALPSGLGFELAGEVLAVGAGVGDLPLGSRVASFPAHTPDHYPAYGDVVLMPRAALAVYPEVLTPVEASVYYTGLLVAYFGLVDLAGLKAGQTVLITEAARMYGPVSIQLAKALGARVIASTKSAEEREFLREQGADKVVVTDEQDLVLEVERFTEGKGVNVILDELGGPQMTLLGDVSATRGKLVLYGCNGGNESAFPACAAFKKHLQFYRHCLMDFTGHPEMGLERNDESVSKALAHIEQLTRDRLLKPVVDRVFEFDQVVEAHRYMETCPKRGRVVIHVAD 96.46 gnl|BL_ORD_ID|1042|hsp_num:0 1041 Z1_01610 Tetracycline repressor protein class A from transposon 1721 Loose 400 206.1 tetR 53.2 3003479 protein overexpression model n/a n/a tetracycline antibiotic antibiotic target alteration; antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MNKLQREAVIRTALELLNDVGMEGLTTRRLAERLGVQQPALYWHFKNKRALLDALAEAMLTINHTHSTPRDDDDWRSFLKGNACSFRRALLAYRDGARIHAGTRPAAPQMEKADAQLRFLCDAGFSAGDATYALMAISYFTVGAVLEQQASEADAEERGEDQLTTSASTMPARLQSAMKIVYEGGPDAAFERGLALIIGGLEKMRLTTNDIEVLKNVDE MMSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS 105.29 gnl|BL_ORD_ID|443|hsp_num:0 276 Z1_01672 Tetracycline repressor protein class H Loose 400 261.2 tetR 66.01 3003479 protein overexpression model n/a n/a tetracycline antibiotic antibiotic target alteration; antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MAKLDKEQVIDNALILLNEVGMEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAETILQKHHHHVLPLANESWQDFLRNNAKSFRQALLMYRDGGKIHAGTRPSANQFETSEQQLQFLCDAGFTLTQAVYALSSIAHFTLGSVLETQEHQESQKEREKVPKTEINYPPLLTQAIDIMDSDNGEAAFLFVLDVMISGLETVLNNHH MMSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS 99.52 gnl|BL_ORD_ID|443|hsp_num:0 276 Z1_02066 HTH-type transcriptional regulator LeuO Loose 500 75.1 MexT 22.01 3000814 protein overexpression model n/a n/a fluoroquinolone antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MTDYTSATTTNKESADMHLRNVDLNLLTVFDAVMQMQNVTRAAQVLGMSQPAVSNAVSRLKIMFNDELFVRYGRGIQPTLRAKQLFGPVRQALQLVHNELPGAGFEPEQSDRVFSLSICSPLDIKLAPKIVERIKNKTPNINVNIKSYLNSNIEHQLKYQEVEFFINYKQFDKPEFHSHPLFNDEVVLAVSNQHPRIKESVTEEMLLNEHHSIVSLEDVGSFSAAYYKNTELEDLITYEGTDLNSVLNLVSKTYSVAIAPRWLVESYSEQLNIKAISLPWEKVERPCYLIWHESTARDKGHLWMKNLLSEVCQN MPVSDPMPLRHLARPRPVSHARLDGEPPRLQPLAPGNEERHEPKRPAPRRSEPADRVRDPDARTQRDPRRRETVPRPAGQPAISAALSRLRTLFDDPLFVRTGRSMEPTARAQEIFAHLSPALDSISTAMSRASEFDPATSTAVFRIGLSDDVEFGLLPPLLRRLRAEAPGFVLVVRRANYLLMPNLLASGEISVGVSYTDELPANAKRKTVRRSKPKILRADSAPGQLTLDDYCARPHALVSFAGDLSGFVDEELEKFGRKRKVVLAVPQFNGLGTLLAGTDIIATVPDYAAQALIAAGGLRAEDPPFETRAFELSMAWRGAQDNDPAERWLRSRISMFIGDPDSL 90.49 gnl|BL_ORD_ID|1487|hsp_num:0 1608 Z1_02155 Exoenzyme S synthesis regulatory protein ExsA Loose 200 46.2 Escherichia coli soxS with mutation conferring antibiotic resistance 29.52 3003511 protein overexpression model n/a n/a fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics antibiotic target alteration; antibiotic efflux; reduced permeability to antibiotic ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams MNTIQCGENTKQDCVIQKLSYFYPQYQILENNQKALYIIRNNALVLQNCTNTITINKDQIIFLQQGNYTIKTLGNEPCETIYIPLSDDFLRNFMSKNSDILSNIDREENFSSAFICFEDSPLIHFCSNGFDYLSSQNCPDTFTQLRIEEMLILLLSSEQGANLMALLRQLSHRQVDRLKIFMEKNHLKNWKLKQFAREFGMGLTTFKELFNHVYGTSPRTWICERRIIYAHQLLLTTEMSIVDISMESGFSSQSYFTQSYHRRFNMTPSKARHLKLKL MSHQKIIQDLIAWIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGYVSQQTFSRVFRRQFDRTPSDYRHRL 259.81 gnl|BL_ORD_ID|1978|hsp_num:0 2066 Z1_02252 HTH-type transcriptional dual regulator CecR Loose 375 40.0 Escherichia coli AcrAB-TolC with AcrR mutation conferring resistance to ciprofloxacin, tetracycline, and ceftazidime 28.81 3003807 protein overexpression model n/a n/a fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic target alteration; antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MKNTSKTAVSTEQTQEKLVQEGIRLFALHGISGLRTRQLAQDAGVNQSAIPYHFGGKLGVYTAVIRYIATELASEIQFDQFDNKLQFLLKENRPYKNEKVAELVLLLVTGLARALLSPKRHYYSQLILREQLEPTENYDLIYSNLIEPFHLRLSRLVGLMDTKSDEVTITIRAHALIGQILGFVIARKAFLLRVNKQEITSQLLDKIAQEISQLSVNALLIENA MARKTKQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSESNIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVGEMAVVQQAQRNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYISGLMENWLFAPQSFDLKKEARDYVAILLEMYLLCPTLRNPATNE 104.19 gnl|BL_ORD_ID|2095|hsp_num:0 2306 Z1_02896 HTH-type transcriptional regulator YidZ Loose 500 52.4 MexT 23.83 3000814 protein overexpression model n/a n/a fluoroquinolone antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MSNKPLHRIDLNLLVIFQILLQERSVTLAAKWLSISPSAVSKALAKLRIWFDDPLFIRSPQGLIPTPLSLSIEDSLSDFINISHHIANKRNTEVPVGLKFNLVLETPLHQVMLPSLPQQILSHYPKSTLQIKNWEYNSLSNIIDGEVDIGLVGREYYSRSKELLELLPDVIDYEILFDDIPLVYLHKNHPLMKMKWDLNNFLSFSQVSTEYDKQSHWALDNILKEMNKSRQIAITYTSFEQSLFMISQPDHQLITCAPGYCRYYVKTHFPDIVTLPIPLPPVFLEQLHLPFVLLWHKRNSHNTKIIWLRNTIRKSINQQISDI MPVSDPMPLRHLARPRPVSHARLDGEPPRLQPLAPGNEERHEPKRPAPRRSEPADRVRDPDARTQRDPRRRETVPRPAGQPAISAALSRLRTLFDDPLFVRTGRSMEPTARAQEIFAHLSPALDSISTAMSRASEFDPATSTAVFRIGLSDDVEFGLLPPLLRRLRAEAPGFVLVVRRANYLLMPNLLASGEISVGVSYTDELPANAKRKTVRRSKPKILRADSAPGQLTLDDYCARPHALVSFAGDLSGFVDEELEKFGRKRKVVLAVPQFNGLGTLLAGTDIIATVPDYAAQALIAAGGLRAEDPPFETRAFELSMAWRGAQDNDPAERWLRSRISMFIGDPDSL 93.08 gnl|BL_ORD_ID|1487|hsp_num:0 1608 Z1_02961 Phthiocerol synthesis polyketide synthase type I PpsC Loose 660 122.1 MexS 28.13 3000813 protein overexpression model n/a n/a fluoroquinolone antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MIKNNDLPAFMTQVVITEPGGVDKLQLENSPLPSLPPHYMLVKVNAAGVNRPDIFQRQGSYPPPADASPILGLEIAGEVVKLGEHCTKWAIGDRVCALVAGGGYAEYCLVHEDIALPSQGLSDIEAAALPENLFTVWANLFQLGQLKAGESVLIHGGTSGIGSMAIMLAHNLGCEIYTTVGSKEKAEVAQKLGANHVINYREKDFATEIPVLTQGKGVDVILDIIGGDYVEKNYQVAAKFGRVIQVGMMKGAPKNLNMMPLMLKRLIHTGSTMRSRTSEEKTHIAQELKQQVWPLIIKGQIKPIINAVFSLQEVAKAHQLMESGDLIGKVVLEIDMNKSLV MSRVIRFHQFGPPEVLKCEELPTPAPAAGEVLVRVQAIGVSWKDVLWRQNLAPEQAALPSGLGFELAGEVLAVGAGVGDLPLGSRVASFPAHTPDHYPAYGDVVLMPRAALAVYPEVLTPVEASVYYTGLLVAYFGLVDLAGLKAGQTVLITEAARMYGPVSIQLAKALGARVIASTKSAEEREFLREQGADKVVVTDEQDLVLEVERFTEGKGVNVILDELGGPQMTLLGDVSATRGKLVLYGCNGGNESAFPACAAFKKHLQFYRHCLMDFTGHPEMGLERNDESVSKALAHIEQLTRDRLLKPVVDRVFEFDQVVEAHRYMETCPKRGRVVIHVAD 100.59 gnl|BL_ORD_ID|1042|hsp_num:0 1041 Z1_03672 S-(hydroxymethyl)glutathione dehydrogenase Loose 660 49.7 MexS 38.37 3000813 protein overexpression model n/a n/a fluoroquinolone antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MKSRAAVAFGPGEPLKIVEVDVMPPQAGEVLIKISHTGVCHTDAFTLSGDDPEGVFPAILGHEGAGVVVEVGEGVTSVKPGDHVIPLYTAECGECLFCKSGKTNLCVAVRATQGKGLMPDGTTRFSYNGQPIYHYMGCSTFSEYTVVAEVSLAKINPQANHEEVCLLGCGVTTGIGAVHNTAKVQEGDSVAVFGLGGIGLAVLQGARQAKAGRIFAIDTNPEKFALARQFGATDCLNPNDYDKPIQEVLVEMTQWGVDHTFECIGNVNVMRAALESAHRGWGQSIIIGVAGAGQEISTRPFQLVTGRSWKGTAFGGVKGRSQLPNMVEDAMNGKIELKPFVTHTLPLEKINEAFDLMHEGKSIRTVIHFD MSRVIRFHQFGPPEVLKCEELPTPAPAAGEVLVRVQAIGVSWKDVLWRQNLAPEQAALPSGLGFELAGEVLAVGAGVGDLPLGSRVASFPAHTPDHYPAYGDVVLMPRAALAVYPEVLTPVEASVYYTGLLVAYFGLVDLAGLKAGQTVLITEAARMYGPVSIQLAKALGARVIASTKSAEEREFLREQGADKVVVTDEQDLVLEVERFTEGKGVNVILDELGGPQMTLLGDVSATRGKLVLYGCNGGNESAFPACAAFKKHLQFYRHCLMDFTGHPEMGLERNDESVSKALAHIEQLTRDRLLKPVVDRVFEFDQVVEAHRYMETCPKRGRVVIHVAD 109.14 gnl|BL_ORD_ID|1042|hsp_num:0 1041