qseqid	Gene ID	Identity	length	gapopen	mismatch	qstart	qend	sstart	send	E_value	bitscore	Protein ID	PHI_MolConn_ID	Gene	Pathogen ID	Multiple mutation	Pathogen species	Pathogen strain	Disease	Host description	Host ID	Host species	Gene Function	Mutant Phenotype	Exp. Technique-stable	PMID
Z1_00001	BAO08779	51.7	495	7	213	3	491	19	493	1.12e-128	381.0	V5XVU3	PHI:4073	Ser	615	nan	Serratia marcescens	2170	hemolymph bleeding	Moths	7091	Bombyx mori (related: domestic silkworm)	virulence factor	reduced virulence	Gene disruption	24530643
Z1_00039	CAD20572	47.0	676	11	324	1	664	1	654	2.15e-193	560.0	Q8MPM3	PHI:8028	Tkt	5665	nan	Leishmania mexicana	M379	leishmaniasis	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Transketolase	loss of pathogenicity	Gene deletion: full; gene complementation	29554142
Z1_00049	AE016755_285	63.5	255	1	90	7	261	2	253	4.88e-110	316.0	A0A0H2VAW4	PHI:11343	c2515	562	PHI:11344_nan	Escherichia coli	E516	avian colibacillosis	Birds	9031	Gallus gallus (related: chicken)	Putative iron transport protein	reduced virulence	Gene deletion: full; gene complementation	33912608
Z1_00050	AE016755_284	70.9	340	0	99	19	358	10	349	3.07e-161	454.0	A0A0H2V4D2	PHI:11344	c2516	562	nan_PHI:11343	Escherichia coli	E516	avian colibacillosis	Birds	9031	Gallus gallus (related: chicken)	Putative iron transport protein	reduced virulence	Gene deletion: full; gene complementation	33912608
Z1_00061	AAF71498	44.3	244	3	123	65	302	97	333	1.09e-60	204.0	Q9JP38	PHI:2975	ipx10	317	nan	Pseudomonas syringae	pv. tomato strain DC3000	bacterial speck (tomato)	Eudicots	4081_3702	Solanum lycopersicum (related: tomato)_Arabidopsis thaliana (related: thale cress)	Effector	effector (plant avirulence determinant)	Gene mutation	11967070
Z1_00064	ABP90468	54.5	431	5	186	1	426	1	426	8.63e-146	421.0	A4VWH9	PHI:11234	Eno	1307	nan	Streptococcus suis	CVCC606	meningitis; septicemia; arthritis; pneumonia (pig)	Even-toed ungulates_Rodents	9823_10090	Sus scrofa (related: pig)_Mus musculus (related: house mouse)	Enolase	unaffected pathogenicity	Functional test in host	33618766
Z1_00067	AAO70421	77.3	743	1	166	1	743	1	740	0.0	1180.0	Q8Z447	PHI:9161	RelA	28901	PHI:9162	Salmonella enterica	subsp. enterica serovar Typhi strain Ty2_subsp. enterica serovar Typhimurium strain SL1344	salmonellosis	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	GTP pyrophosphokinase	reduced virulence	Gene deletion: full; gene complementation	31013389
Z1_00073	AAY47966	61.5	423	1	162	2	424	4	425	1.9999999999999999e-193	541.0	Q4UYA7	PHI:3950	XC_0892	339	nan	Xanthomonas campestris	pv. campestris strain 8004	black rot	Eudicots	3726	Raphanus sativus (related: radish)	Glutamate-1-semialdehyde aminotransferase	reduced virulence	Gene mutation	23819805
Z1_00077	AAD01437	94.7	151	0	8	1	151	1	151	9.82e-101	284.0	P0A1G5	PHI:6508	DksA	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Response Regulator	reduced virulence	Gene mutation; gene complementation	26553464
Z1_00083	AAY49516	45.5	123	0	67	4	126	4	126	3.97e-35	116.0	Q4UTV7	PHI:3968	XC_2466	339	nan	Xanthomonas campestris	pv. campestris strain 8004	black rot	Eudicots	3726	Raphanus sativus (related: radish)	Aspartate alpha-decarboxylase	reduced virulence	Gene mutation	23819805
Z1_00101	AAC74104	50.1	407	2	197	20	420	14	420	2.63e-144	416.0	P31545	PHI:10992	efeB	562	PHI:10991	Escherichia coli	PCN033	infection	Rodents	10090	Mus musculus (related: house mouse)	Deferrochelatase/peroxidase	unaffected pathogenicity	Gene deletion: full	32962530
Z1_00114	AAC73234	61.6	526	4	190	1	524	1	516	4.21e-237	659.0	P36649	PHI:10985	cueO	562	nan	Escherichia coli	PCN033	infection	Rodents	10090	Mus musculus (related: house mouse)	Blue copper oxidase	reduced virulence	Gene deletion: full	32962530
Z1_00119	AFR03725	52.5	200	1	94	11	210	9	207	2.4399999999999997e-68	206.0	J7KWZ6	PHI:3711	PCC21 _023220	554	nan	Pectobacterium carotovorum	subsp. carotovorum strain Pcc21	soft rot	Eudicots	3711	Brassica rapa (related: field mustard)	Putative DNA-binding protein	reduced virulence	Gene mutation; gene complementation	23676432
Z1_00131	AAL23350	89.3	717	2	75	1	716	1	716	0.0	1267.0	Q8ZJY5	PHI:7575	yjiY	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028	salmonellosis	Nematodes_Rodents	6239_10090	Caenorhabditis elegans (related: roundworm)_Mus musculus (related: house mouse)	Peptide-utilizing carbon starvation protein	reduced virulence_unaffected pathogenicity	Gene deletion: full; gene complementation	26497384
Z1_00138	CAG74082	54.5	44	0	20	1	44	1	44	9.6e-11	49.3	Q6D803	PHI:8933	rsmS (ECA1172)	29471	nan	Pectobacterium atrosepticum	SCRI 1043	soft rot (potato); blackleg disease (potato)	Eudicots	4113	Solanum tuberosum (related: potato)	Uncharacterized protein	increased virulence (hypervirulence)	Gene deletion: full	30872786
Z1_00142	AAA74436	51.3	372	7	157	5	373	8	358	1.03e-111	330.0	P52477	PHI:11922	mexA	287	PHI:11923	Pseudomonas aeruginosa	PAO1	infection	Rodents	10090	Mus musculus (related: house mouse)	Multidrug resistance protein	unaffected pathogenicity	Gene deletion: full; gene complementation	34680745
Z1_00143	CBW16569	76.4	1045	2	243	1	1044	1	1042	0.0	1534.0	A0A0H3N916	PHI:7307	AcrB	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain SL1344	salmonellosis	Primates_Moths_Rodents	7137_10090_9606	Homo sapiens (related: human)_Galleria mellonella (related: greater wax moth)_Mus musculus (related: house mouse)	Efflux pump membrane transporter	reduced virulence	Gene deletion: full_Gene mutation	28720734
Z1_00145	CAL21733	88.1	67	0	8	1	67	1	67	5.11e-39	121.0	P0A3X0	PHI:3819	ymoA	632	nan	Yersinia pestis	KIM/D27	pneumonic plague	Rodents	10090	Mus musculus (related: house mouse)	represses the transcription and expression of T3SS genes at room temperature	increased virulence (hypervirulence)	Gene deletion	23988036
Z1_00156	AAT05019	41.5	94	2	51	276	367	143	234	2.32e-10	60.5	Q71XE6	PHI:6137_PHI:7070	prsA2_PrsA2	1639	PHI:7069_nan	Listeria monocytogenes	10403S	listeriosis	Marsupials_Primates_Rodents	9606_10090_9310	Homo sapiens (related: human)_Potorous tridactylus (related: long-nosed potoroo)_Mus musculus (related: house mouse)	Secreted chaperone_Foldase	reduced virulence_unaffected pathogenicity	Gene mutation_Gene mutation; gene complementation	27007641_27481256
Z1_00157	AAM35959	70.0	90	0	27	6	95	1	90	1.13e-38	122.0	Q8NL12	PHI:8676	hupB (XAC1081)	346	nan	Xanthomonas citri	subsp. citri strain 306	canker (citrus)	Eudicots	2708	Citrus limon (related: lemon)	Histone-like protein	reduced virulence	Gene mutation; gene complementation	30537413
Z1_00158	CBJ45669	89.2	784	0	85	1	784	1	784	0.0	1359.0	D4HY24	PHI:7160	lon	552	PHI:7161_nan	Erwinia amylovora	Ea1189	fire blight	Eudicots	23211	Pyrus communis (related: pear)	Protease	loss of pathogenicity_increased virulence (hypervirulence)	Gene deletion: full; gene complementation_Gene mutation	28509355
Z1_00159	AAM40281	75.8	422	2	98	5	423	8	428	3.76e-225	621.0	Q8PBY5	PHI:9833	clpX	339	nan	Xanthomonas campestris	pv. campestris strain Xc17	black rot	Eudicots	3712	Brassica oleracea (no common name found)	ATP-binding subunit of ATP-dependent Clp protease	reduced virulence	Gene mutation; gene complementation	31741013
Z1_00160	BAA94668	85.0	207	0	31	1	207	1	207	1.4e-125	351.0	P0A1D7	PHI:3040	ClpP	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain C5	food poisoning	Rodents	10090	Mus musculus (related: house mouse)	proteolytic component	reduced virulence	Gene deletion: full; gene complementation	23676436
Z1_00167	AAM36129	54.4	281	5	118	17	289	20	298	2.850000000000001e-103	303.0	Q8PN16	PHI:4147	XAC1258	346	nan	Xanthomonas citri	subsp. citri	canker (citrus)	Eudicots	2711	Citrus sinensis (related: sweet orange)	CyoA, cytochrome O ubiquinol oxidase	reduced virulence	Gene mutation	24676796
Z1_00168	BAF67201	47.8	638	8	315	29	660	28	653	4.35e-203	584.0	A6QFR9	PHI:4038	qoxB	1280	nan	Staphylococcus aureus	nan	skin infection; food poisoning; respiratory disease	Rodents	10090	Mus musculus (related: house mouse)	Terminal Oxidases	reduced virulence	Gene mutation	24302255
Z1_00172	AAY50743	48.8	164	3	80	25	187	1	161	2.0100000000000003e-43	140.0	Q4UQD0	PHI:3259	XC_3703	339	PHI:3260_nan	Xanthomonas campestris	pv. campestris strain 8004	black rot	Eudicots	3726	Raphanus sativus (related: radish)	Cyclic di-GMP Effectors	reduced virulence_effector (plant avirulence determinant)	Gene deletion: full	25329577
Z1_00192	AAK33390	45.6	147	0	80	1	147	1	147	3.2400000000000007e-43	139.0	P67320	PHI:3464	nrdR	1314	PHI:3465_nan	Streptococcus pyogenes	1529	toxic shock syndrome	Rodents	10090	Mus musculus (related: house mouse)	regulator	reduced virulence_unaffected pathogenicity	Gene mutation; gene complementation	25469586
Z1_00199	CBW16497	79.0	200	0	42	1	200	1	200	8.439999999999999e-119	333.0	A0A0H3NDI1	PHI:11384	tsaA	28901	PHI:11383	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028	salmonellosis	Moths	7137	Galleria mellonella (related: greater wax moth)	Peroxiredoxin	reduced virulence	Gene deletion: full	33732665
Z1_00200	AAD08162	48.1	538	2	277	15	551	20	556	6.86e-177	511.0	O25743	PHI:3146	GGT	210	nan	Helicobacter pylori	G27	gastric infection	Moths	7137	Galleria mellonella (related: greater wax moth)	virulence determinants	unaffected pathogenicity	Gene mutation	25170542
Z1_00204	AAC74741	68.6	223	1	69	1	223	1	222	1.12e-118	335.0	P77375	PHI:10998	ydhX	562	nan	Escherichia coli	PCN033	infection	Rodents	10090	Mus musculus (related: house mouse)	Putative 4Fe-4S ferredoxin-like protein	unaffected pathogenicity	Gene deletion: full	32962530
Z1_00213	AAL19352	62.4	428	0	161	1	428	1	428	5.23e-197	550.0	Q8ZRE1	PHI:9434	phoR	28901	PHI:9435_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	gastroenteritis	Rodents	10090	Mus musculus (related: house mouse)	Histidine kinase	reduced virulence_increased virulence (hypervirulence)	Gene mutation: characterised	31346161
Z1_00214	AAL19351	79.5	229	0	47	1	229	1	229	8.6e-140	389.0	Q7CR43	PHI:123534	phoB	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028s	gastroenteritis	Rodents	10090	Mus musculus (related: house mouse)	Transcriptional regulator	reduced virulence	Gene deletion: full	31610610
Z1_00222	AAA97109	67.9	639	0	205	11	649	9	647	0.0	929.0	P08331	PHI:7020	cpdB	562	nan	Escherichia coli	APEC-34 O91	colibacillosis	Birds	9031	Gallus gallus (related: chicken)	2′,3′-Cyclic phosphodiesterase	reduced virulence	Gene mutation	28266315
Z1_00225	AAL20878	94.7	76	0	4	5	80	2	77	4.17e-50	150.0	P0AA34	PHI:7643	yedF	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain SL1344	salmonellosis	Primates	9606	Homo sapiens (related: human)	Hypothetical transcription factor	reduced virulence	Gene mutation; gene complementation	29127378
Z1_00227	ACY89868	66.0	335	0	114	5	339	2	336	5.49e-162	454.0	A0A0F6B5S4	PHI:10079	STM14_RS15330	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Formate hydrogenlyase transcriptional activator	unaffected pathogenicity	Gene deletion: full	32038592
Z1_00228	ACY89867	65.9	375	1	122	1	375	1	369	6.15e-192	533.0	A0A0F6B5S3	PHI:10078	STM14_RS15325	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Hydrogenase expression/formation protein	unaffected pathogenicity	Gene deletion: full	32038592
Z1_00230	ACY89865	75.2	234	0	58	155	388	57	290	1.65e-126	364.0	A0A0F6B5S1	PHI:10076	STM14_RS15315	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Hydrogenase assembly chaperone	unaffected pathogenicity	Gene deletion: full	32038592
Z1_00235	AAC76032	73.3	337	2	81	1	337	1	328	1.33e-190	526.0	P0AAJ8	PHI:10995	hybA	562	PHI:10996	Escherichia coli	PCN033	infection	Rodents	10090	Mus musculus (related: house mouse)	Hydrogenase-2 operon protein	unaffected pathogenicity	Gene deletion: full	32962530
Z1_00236	AAC76033	79.3	368	1	75	1	368	1	367	9.09e-223	611.0	P69741	PHI:10996	hybO	562	PHI:10995	Escherichia coli	PCN033	infection	Rodents	10090	Mus musculus (related: house mouse)	Hydrogenase-2 small chain	unaffected pathogenicity	Gene deletion: full	32962530
Z1_00244	EJP63790	44.9	274	4	142	1	267	31	302	6.82e-73	224.0	J4VZT4	PHI:9444	Bbakr1 (XP_008600433.1)	176275	nan	Beauveria bassiana	Bb0062	white muscardine	Moths	7137	Galleria mellonella (related: greater wax moth)	Aldo/keto reductase	unaffected pathogenicity	Altered gene expression / gene regulation: overexpression_Gene disruption; gene complementation	29305969
Z1_00245	CAA77642	43.6	362	3	197	154	512	191	548	1.23e-83	295.0	P43261	PHI:7913	eae	562	nan	Escherichia coli	EDL933	urinary tract infection	Primates	9606	Homo sapiens (related: human)	Intimin	unaffected pathogenicity	Gene deletion: full	29533744
Z1_00247	ADN00101	84.9	378	0	57	1	378	1	378	9.64e-242	660.0	E0SH08	PHI:8577	carA (Dda3937_01390)	204038	nan	Dickeya dadantii	3937	soft rot	Eudicots	13427	Cichorium intybus (related: chicory)	Carbamoyl-phosphate synthase small subunit	reduced virulence	Gene deletion: full	30267562
Z1_00255	CAA27969	76.8	297	0	69	1	297	1	297	4.37e-172	477.0	P0A9G2	PHI:3267	nhaR	562	PHI:3266	Escherichia coli	536	infection	Rodents	10090	Mus musculus (related: house mouse)	Transcriptional activator protein	reduced virulence	Gene mutation: characterised; gene complementation	25268639
Z1_00256	AAA23448	59.9	374	1	149	5	377	4	377	2.62e-155	441.0	P13738	PHI:3266	nhaA	562	PHI:3267_nan	Escherichia coli	536	infection	Rodents	10090	Mus musculus (related: house mouse)	Antiporter gene	reduced virulence	Gene mutation: characterised; gene complementation	25268639
Z1_00257	AE004889_9	59.2	380	3	148	1	376	1	377	7.89e-136	391.0	Q9HV44	PHI:10485	dnaJ	287	nan	Pseudomonas aeruginosa	PAO1	opportunistic infection	Flies	7227	Drosophila melanogaster (related: fruit fly)	Heat shock protein	reduced virulence	Gene mutation; gene complementation	32178243
Z1_00263	STV70203	73.9	257	1	66	1	257	294	549	2.06e-126	368.0	A0A378CFB4	PHI:11408	yaaA	573	nan	Klebsiella pneumoniae	ATCC 43816; MKP203	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Alanine/glycine transport protein	reduced virulence	Gene deletion: full; gene complementation	31988174
Z1_00268	AAA97297	92.0	238	0	19	1	238	1	238	2.63e-159	439.0	P0A9Q1	PHI:6532	arcA	562	nan	Escherichia coli	XM	meningitis	Birds	8839	Anas platyrhynchos (related: mallard)	Aerobic respiration control protein	reduced virulence	Gene mutation; gene complementation	26099584
Z1_00270	AIK80589	50.0	102	0	51	6	107	7	108	5.99e-31	110.0	Q48413	PHI:7475	ramA (VK055_1983)	573	PHI:7488; PHI:7489; PHI:7490; PHI:7476; PHI:7477; PHI:7491; PHI:7492; PHI:7493; PHI:7494; PHI:7495; PHI:7496; PHI:7497; PHI:7498; PHI:7499; PHI:7500; PHI:7501; PHI:7502; PHI:7503; PHI:7504; PHI:7505; PHI:7506; PHI:7507; PHI:7508; PHI:7509; PHI:7510; PHI:7511; PHI:7512_PHI:7476; PHI:7477_nan	Klebsiella pneumoniae	KPPR1	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Bacterial regulatory helix-turn-helix, AraC family protein	unaffected pathogenicity	Gene deletion: full	28861522
Z1_00286	ARA47408	74.4	215	0	55	1	215	1	215	3.04e-113	321.0	W9B383	PHI:11405	dedA	573	nan	Klebsiella pneumoniae	ATCC 43816; MKP203	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	DedA family inner membrane protein	reduced virulence	Gene deletion: full; gene complementation	31988174
Z1_00294	BAB41677	47.1	221	1	116	14	234	4	223	3.63e-58	186.0	A0A0H3JLK2	PHI:4960	rsmI	1280	nan	Staphylococcus aureus	RN4220	skin infection; food poisoning; respiratory disease	Moths	7091	Bombyx mori (related: domestic silkworm)	Ribosomal RNA small subunit methyltransferase I	reduced virulence	Gene deletion: full; gene complementation	25893373
Z1_00300	CAR47188	99.5	221	0	1	1	221	2	222	2.21e-161	443.0	P17091	PHI:123444	ureF	584	PHI:123443_PHI:123442	Proteus mirabilis	HI4320	catheter-associated urinary tract infection	Rodents	10090	Mus musculus (related: house mouse)	Urease accessory protein UreF	unaffected pathogenicity	Gene deletion: full	32255226
Z1_00302	EFY97162	62.0	571	4	210	1	567	270	837	2.21e-252	712.0	E9F5A9	PHI:9533	urease (MAA_07458)	568076	nan	Metarhizium robertsii	ARSEF 2575	nan	Monocots_Beetles_Moths	7067_7137_4513	Galleria mellonella (related: greater wax moth)_Hordeum vulgare (related: barley)_Tenebrio molitor (related: yellow mealworm)	Urease	unaffected pathogenicity	Gene mutation	31618269
Z1_00304	BAA84532	61.0	100	1	38	1	99	1	100	7.5e-35	117.0	P14916	PHI:7264	UreA	210	nan	Helicobacter pylori	X47	gastric infection	Rodents	10090	Mus musculus (related: house mouse)	Hydrolase	reduced virulence	Gene mutation	28644872
Z1_00321	ADM96537	72.2	457	3	124	4	459	2	456	6.56e-222	616.0	E0SHD8	PHI:8575	degQ (Dda3937_00697)	204038	nan	Dickeya dadantii	3937	soft rot	Eudicots	13427	Cichorium intybus (related: chicory)	Protease	reduced virulence	Gene deletion: full	30267562
Z1_00326	AAG07838	60.4	419	2	163	1	416	1	419	2.17e-174	492.0	Q9HVW7	PHI:7630	murA	287	nan	Pseudomonas aeruginosa	PAO1	infection	Eudicots_Rodents	4236_10090	Lactuca sativa (related: garden lettuce)_Mus musculus (related: house mouse)	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	reduced virulence_unaffected pathogenicity	Gene deletion: full	29045498
Z1_00334	YP_169795	51.3	312	3	147	12	320	14	323	2.67e-100	296.0	Q5NGP7	PHI:7067	KdsD	263	nan	Francisella tularensis	SCHU S4	tularemia	Rodents	10090	Mus musculus (related: house mouse)	D-arabinose 5-phosphate isomerase	reduced virulence	Gene disruption; gene complementation	28328947
Z1_00339	CBA19258	69.5	491	1	136	1	491	1	477	9.870000000000001e-234	648.0	D4HUY5	PHI:3673_PHI:3679_PHI:2906	rpoN	552	nan	Erwinia amylovora	HKN06P1_Ea1189	fire blight	Eudicots	3750_23211	Malus domestica (related: apple)_Pyrus communis (related: pear)	Sigma factor, regulating essential virulence gene expression_a nitrogen limitation sigma factor	loss of pathogenicity	Gene mutation_Gene mutation; gene complementation	23721085_23937726
Z1_00340	CBA19257	64.2	95	0	34	1	95	1	95	4.57e-41	129.0	D4HUY4	PHI:3674_PHI:3680	yhbH	552	nan	Erwinia amylovora	Ea1189	fire blight	Eudicots	3750_23211	Malus domestica (related: apple)_Pyrus communis (related: pear)	a novel ribosome-associated modulation protein	loss of pathogenicity	Gene mutation; gene complementation	23937726
Z1_00341	CAH22766	70.5	149	1	43	1	149	7	154	1.91e-72	213.0	Q665I9	PHI:3133	ptsN	633	nan	Yersinia pseudotuberculosis	YPIII	gut-associated disease; diarrhea; enteritis; colitis	Rodents	10090	Mus musculus (related: house mouse)	Part of the pyruvate - tricarboxylic acid cycle node	reduced virulence	Gene disruption	25164818
Z1_00342	AAY48376	47.6	271	3	137	4	270	1	270	7.479999999999999e-84	251.0	Q4UX47	PHI:7824	HpaP (XC_1307)	339	nan	Xanthomonas campestris	pv. campestris strain 8004	black rot	Eudicots	3712_4072	Brassica oleracea (no common name found)_Capsicum annuum (no common name found)	Regulatory protein with ATPase and phosphatase activity	reduced virulence	Gene deletion: full; gene complementation	29345052
Z1_00349	AAY48578	60.5	479	1	185	2	480	5	479	2.0900000000000006e-195	550.0	Q4UWJ5	PHI:3952	XC_1510	339	nan	Xanthomonas campestris	pv. campestris strain 8004	black rot	Eudicots	3726	Raphanus sativus (related: radish)	TldD protein, DNA gyrase control?	reduced virulence	Gene mutation	23819805
Z1_00359	AAX97431	41.0	61	0	36	95	155	72	132	4.38e-06	42.4	Q2KKC1	PHI:8542	OadD	1351	nan	Enterococcus faecalis	JH2-2	nosocomial infection	Primates_Moths_Rodents	7137_10090_9606	Homo sapiens (related: human)_Galleria mellonella (related: greater wax moth)_Mus musculus (related: house mouse)	Biotin acceptor protein	reduced virulence	Gene deletion: full	30335810
Z1_00360	CAG62563	42.4	439	4	246	5	440	633	1067	4.260000000000001e-110	355.0	Q6FJK7	PHI:123297	DUR1,2	5476	nan	Candida albicans	nan	disseminated candidiasis	Rodents	10090	Mus musculus (related: house mouse)	urea amidolyase	reduced virulence	Gene deletion: full; gene complementation	35795910
Z1_00365	ACT11296	95.9	98	0	4	1	98	1	98	2.08e-61	180.0	C6DIJ6	PHI:10577	PccS1_001523	554	nan	Pectobacterium carotovorum	subsp. carotovorum strain PccS1	soft rot	Monocots	69721	Zantedeschia aethiopica (related: arum-lily)	Transcriptional regulator, Fis family, Fis	unaffected pathogenicity	Gene deletion: full; gene complementation	32267092
Z1_00389	EFE21438	63.6	712	3	254	77	787	24	731	2.2599999999999998e-297	832.0	D4F9X0	PHI:11870	cadA	636	PHI:11871_PHI:11872_nan	Edwardsiella tarda	TX01	edwardsiellosis	Rodents_Bony fishes_Primates	8128_10090_9606	Homo sapiens (related: human)_Oreochromis niloticus (related: nile tilapia)_Mus musculus (related: house mouse)	Lysine-dependent acid resistance (LDAR) system protein	reduced virulence_unaffected pathogenicity	Gene deletion: full; gene complementation	34521475
Z1_00397	AAL21246	40.1	314	0	188	5	318	5	318	4.05e-73	228.0	Q8ZND1	PHI:123532	pagR (STM2345)	28901	PHI:123533_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028s	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	transcriptional regulator	reduced virulence	Gene deletion: full_Gene deletion: full; gene complementation	31610610
Z1_00398	AE004897_4	42.4	158	2	89	10	165	10	167	7e-36	121.0	Q9HUW9	PHI:10782	PA4841	287	nan	Pseudomonas aeruginosa	PAO1161	infection	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	Nudix hydrolase domain-containing protein	unaffected pathogenicity	Gene deletion: full; gene complementation	32419387
Z1_00402	CBA21663	82.2	505	0	90	1	505	1	505	7.99e-309	840.0	D4HXG4	PHI:9317	purF	552	nan	Erwinia amylovora	HKN06P1	fire blight	Eudicots	3750	Malus domestica (related: apple)	Amidophosphoribosyltransferase	reduced virulence	Gene mutation	31152019
Z1_00406	AAW36851	47.0	264	1	137	13	276	17	277	2.83e-75	231.0	Q5HF73	PHI:10348	accD	1280	nan	Staphylococcus aureus	AH1263	skin infection; food poisoning; respiratory disease	Rodents	10090	Mus musculus (related: house mouse)	Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta	reduced virulence	Gene deletion: full	32430471
Z1_00407	ACR27839	48.3	207	2	102	9	212	2	206	2.92e-63	195.0	C5ABM8	PHI:123500	dbcA(bglu_1g06460)	337	nan	Burkholderia glumae	BGR1	bacterial panicle blight (rice)	Monocots	4530	Oryza sativa (related: rice)	membrane transporter	reduced virulence	Gene deletion: full; gene complementation	34260305
Z1_00420	EAL88405	43.4	389	7	183	7	358	5	393	3.21e-97	293.0	Q4WJ77	PHI:7654	aroB	746128	nan	Aspergillus fumigatus	AfS35	invasive pulmonary aspergillosis	Rodents	10090	Mus musculus (related: house mouse)	Chorismate synthase	reduced virulence	Gene deletion: full; gene complementation	26605426
Z1_00421	AAY48631	47.5	297	3	150	9	302	5	298	1.77e-87	263.0	Q4UWE2	PHI:3966	XC_1565	339	nan	Xanthomonas campestris	pv. campestris strain 8004	black rot	Eudicots	3726	Raphanus sativus (related: radish)	N-5-glutamine S-adenosyl-L-methionine-dependent methyltransferase	reduced virulence	Gene mutation	23819805
Z1_00425	AAM36741	40.2	87	1	50	115	201	128	212	3.38e-12	66.2	Q8PLC3	PHI:8852	rpfF	346	nan	Xanthomonas citri	subsp. citri strain 306	canker (citrus)	Eudicots	37656	Citrus x paradisi (related: grapefruit)	Putative enoyl-CoA hydratase	unaffected pathogenicity	Gene mutation	30654743
Z1_00429	ACL33700	46.4	248	3	129	2	247	3	248	9.8e-72	218.0	B8F8P8	PHI:6900	vacJ	738	nan	Glaesserella parasuis	HS49	glasser's disease	Rodents	10090	Mus musculus (related: house mouse)	virulence related outer membrane lipoprotein	reduced virulence	Gene deletion: full; gene complementation	27988234
Z1_00451	ABO11237	51.6	669	5	314	7	671	8	670	3.94e-230	654.0	A3M2U3	PHI:7809	adeN	470	nan	Acinetobacter baumannii	ATCC 17978	nosocomial infection	Moths	7137	Galleria mellonella (related: greater wax moth)	TetR type regulator	increased virulence (hypervirulence)	Gene disruption; gene complementation	28436748
Z1_00454	EAL93059	41.7	314	7	170	9	313	18	327	2.0000000000000003e-64	210.0	Q4X256	PHI:6556	mecA	746128	PHI:6557_nan	Aspergillus fumigatus	ATCC 46645	invasive pulmonary aspergillosis	Rodents	10090	Mus musculus (related: house mouse)	Cystathionine-beta -synthase	reduced virulence_unaffected pathogenicity	Gene deletion: full	26787716
Z1_00455	CBA21825	87.1	85	0	11	1	85	1	85	2.9799999999999998e-46	141.0	D4HXP5	PHI:9311	ptsH	552	nan	Erwinia amylovora	HKN06P1	fire blight	Eudicots	3750	Malus domestica (related: apple)	Phosphocarrier protein HPr	reduced virulence	Gene mutation	31152019
Z1_00456	CBA21827	77.7	575	0	128	1	575	1	575	1.59e-318	870.0	D4HXP6	PHI:9312	ptsI	552	nan	Erwinia amylovora	HKN06P1	fire blight	Eudicots	3750	Malus domestica (related: apple)	Phosphoenolpyruvate-protein phosphotransferase	reduced virulence	Gene mutation	31152019
Z1_00476	AAC44154	68.8	141	0	44	1	141	1	141	1.14e-65	194.0	Q59636	PHI:6438	Ndk	287	nan	Pseudomonas aeruginosa	PAO1	nosocomial infection	Rodents	10090	Mus musculus (related: house mouse)	Host-responsive regulator/Nucleoside diphosphate kinase	increased virulence (hypervirulence)	Gene mutation	27345215
Z1_00479	ACY89541	40.9	115	1	65	17	131	142	253	5.24e-23	89.4	D0ZRW0	PHI:3761	sseB	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	self-limiting gastroenteritis; typhoid-like disease (mice)	Rodents	10090	Mus musculus (related: house mouse)	Secreted effector protein	effector (plant avirulence determinant)	Gene mutation; gene complementation	23950998
Z1_00486	APQ81541	89.8	128	0	13	1	128	1	128	5.849999999999998e-82	234.0	A0A0L9JQ40	PHI:6892	iscU	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain 12023	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Fe-S cluster sensor	reduced virulence	Gene mutation	27704705
Z1_00488	CAH22098	80.5	164	2	30	1	163	1	163	5.740000000000001e-88	253.0	Q667Y0	PHI:7900_PHI:3043	iscR_IscR	633	nan	Yersinia pseudotuberculosis	IP2666	gastrointestinal disease; yersiniosis_zoonotic infection	Even-toed ungulates_Rodents	10090_9940	Ovis aries (related: sheep)_Mus musculus (related: house mouse)	Type III secretion system_HTH-type transcriptional regulator	reduced virulence	Gene mutation: characterised; gene complementation_Gene mutation	29520342_24945271
Z1_00490	ABJ13079	54.6	271	2	119	1	267	1	271	1.42e-94	278.0	Q02RX2	PHI:3915	SuhB	287	nan	Pseudomonas aeruginosa	PAK	nosocomial infection	Rodents	10090	Mus musculus (related: house mouse)	an essential gene for the T3SS gene expression	loss of pathogenicity	Gene mutation	24169572
Z1_00494	ACR70340	86.8	417	0	55	1	417	1	417	1.7700000000000002e-272	740.0	C5BEV2	PHI:2962	glyA	67780	nan	Edwardsiella ictaluri	93-146	enteric septicemia	Bony fishes	7998	Ictalurus punctatus (related: channel catfish)	Serine h ydroxymethyltra nsferase	reduced virulence	Gene deletion: partial	23762452
Z1_00495	QKV33237	99.5	396	0	2	1	396	1	396	9.21e-294	792.0	A0A7U1CQE7	PHI:123275	hmpA	584	nan	Proteus mirabilis	BA6163_HI4320	urinary tract infection; urolithiasis	Primates	9606	Homo sapiens (related: human)	Flavohemoprotein	loss of pathogenicity	Gene deletion	35651758
Z1_00499	ACD58129_nan	43.0	379	2	209	1	374	4	380	4.45e-93	287.0	A0A0K0GIH5	PHI:10487_PHI:9027	PXO_RS06935_pilR (PXO_04881)	347	nan	Xanthomonas oryzae	pv. oryzae strain PXO99A	bacterial leaf blight_bacterial blight (rice)	Eudicots_Monocots	4530	Oryza sativa (related: rice)	Response regulator	reduced virulence_unaffected pathogenicity	Gene deletion: full; gene complementation_Gene mutation	30828283_32112711
Z1_00501	EBV8836849	57.8	479	3	198	4	482	1	475	1.89e-180	512.0	A0A5Z5IUY8	PHI:12148	qseE	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ST4/74	infection	Rodents_Moths_Primates	7137_10090_9606	Homo sapiens (related: human)_Galleria mellonella (related: greater wax moth)_Mus musculus (related: house mouse)	Two-component regulatory system protein	unaffected pathogenicity	Gene deletion: full	35137015
Z1_00502	ADM99559	75.6	1295	2	314	1	1295	2	1294	0.0	2005.0	E0SB00	PHI:8580	purL (Dda3937_03379)	204038	nan	Dickeya dadantii	3937	soft rot	Eudicots	13427	Cichorium intybus (related: chicory)	Phosphoribosylformyl-glycineamide synthetase	reduced virulence	Gene deletion: full	30267562
Z1_00514	AAK33487	45.0	291	4	156	9	297	5	293	8.61e-81	245.0	P0C0B9	PHI:11438	bglB	1314	PHI:11439_nan	Streptococcus pyogenes	5448	infection	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Putative phospho--glucosidase	reduced virulence_increased virulence (hypervirulence)	Gene deletion: full; gene complementation	32719156
Z1_00515	AAA92440	85.4	226	0	33	1	226	1	226	2.79e-139	387.0	Q56056	PHI:3724	RNase III	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain SL1344	food poisoning	Moths	7137	Galleria mellonella (related: greater wax moth)	endoribonucleases	reduced virulence	Gene mutation; gene complementation	23913419
Z1_00521	CAR43933	100.0	192	0	0	1	192	1	192	1.07e-133	370.0	B4F053	PHI:5238	RpoE	584	nan	Proteus mirabilis	N2	urinary tract infection	Rodents	10090	Mus musculus (related: house mouse)	RNA polymerase sigma-E factor	reduced virulence	Gene disruption; gene complementation	25547796
Z1_00532	ABJ02039	85.0	160	0	24	1	160	1	160	9.55e-101	285.0	A1AEE9	PHI:4218	smpB	562	nan	Escherichia coli	E058	avian colibacillosis	Birds	9031	Gallus gallus (related: chicken)	trans -translation is a bacterial translational control system that directs the modification and degradation of proteins,	reduced virulence	Gene disruption; gene complementation	24013628
Z1_00540	AIK80588	53.8	676	14	275	20	667	6	672	1.3e-232	660.0	D8L2S4	PHI:7477	orf82 (VK055_1982)	573	PHI:7475; PHI:7476_nan_PHI:7488; PHI:7489; PHI:7490; PHI:7476; PHI:7475; PHI:7491; PHI:7492; PHI:7493; PHI:7494; PHI:7495; PHI:7496; PHI:7497; PHI:7498; PHI:7499; PHI:7500; PHI:7501; PHI:7502; PHI:7503; PHI:7504; PHI:7505; PHI:7506; PHI:7507; PHI:7508; PHI:7509; PHI:7510; PHI:7511; PHI:7512	Klebsiella pneumoniae	KPPR1	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Hypothetical protein_hypothetical protein	unaffected pathogenicity	Gene deletion: full	28861522
Z1_00554	AGY90568	48.5	493	2	251	4	496	3	492	5.83e-170	487.0	Q5HDJ0	PHI:6190	Mqo	1280	PHI:6191_nan	Staphylococcus aureus	Newman	skin infection; food poisoning; respiratory disease	Rodents	10090	Mus musculus (related: house mouse)	malate-quinone oxidoreductases	reduced virulence	Gene mutation	26851155
Z1_00570	AAK49483	57.0	676	4	286	5	679	11	682	3.94e-282	786.0	Q93FB0	PHI:6654	ireA	562	nan	Escherichia coli	DE205B	avian colibacillosis	Birds	8839	Anas platyrhynchos (related: mallard)	Iron-regulated outer membrane virulence protein	unaffected pathogenicity	Gene mutation; gene complementation	27531140
Z1_00574	CAA26172	64.1	370	0	133	12	381	11	380	3.47e-168	474.0	P0A6T3	PHI:6269	galK	562	nan	Escherichia coli	UTI89	urinary tract infection	Rodents	10090	Mus musculus (related: house mouse)	Galactokinase	reduced virulence	Gene mutation	27073089
Z1_00576	CAA40568	61.0	336	0	131	1	336	1	336	5.8e-150	424.0	P24325	PHI:9264	galE	727	PHI:9263_nan	Haemophilus influenzae	NTHi 375	nosocomial infection	Rodents	10090	Mus musculus (related: house mouse)	UDP-glucose 4-epimerase	reduced virulence_unaffected pathogenicity	Gene mutation; gene complementation	31157175
Z1_00580	CAH35049	43.5	131	1	73	23	153	44	173	2.8100000000000003e-37	124.0	Q63W37	PHI:4101	Eco	28450	nan	Burkholderia pseudomallei	K96423	melioidosis	Rodents	10090	Mus musculus (related: house mouse)	serine protease inhibitor	reduced virulence	Gene mutation	24462575
Z1_00584	ACY89870	67.9	109	1	33	1	107	1	109	6.47e-50	152.0	A0A0F6B5S6	PHI:10081	STM14_RS15340	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Iron ABC transporter substrate-binding protein	unaffected pathogenicity	Gene deletion: full	32038592
Z1_00587	AAA25816_AE004598_1	47.4	249	1	130	24	272	20	267	3.1e-75	229.0	P26993	PHI:6399_PHI:6992_PHI:12233_PHI:8765	exsa_ExsA_exsA	287	PHI:12232_nan	Pseudomonas aeruginosa	PA103_PAO1_PA14	nosocomial infection_opportunistic infection_infection	Rodents	10090	Mus musculus (related: house mouse)	HTH-type transcriptional regulator_Exoenzyme S synthesis regulatory protein_iT3SS: translocating effectors in the host cells_Type III secretion regulator	reduced virulence	Other evidence: chemical inhibition_Gene deletion: full; gene complementation_Gene mutation	30618115_35336241_27412581_28246361
Z1_00606	EJP68141	40.4	513	9	278	15	502	82	591	1.4200000000000002e-110	338.0	J5K1T7	PHI:9409	Krs (BBA_03037)	176275	nan	Beauveria bassiana	ARSEF 2860	white muscardine	Moths	7137	Galleria mellonella (related: greater wax moth)	Lysine-tRNA synthetase	reduced virulence	Gene deletion: full; gene complementation	29029702
Z1_00617	ACR70489	70.9	959	2	277	1	957	1	959	0.0	1380.0	C5BAT0	PHI:2961	gcvP	67780	nan	Edwardsiella ictaluri	93-146	enteric septicemia	Bony fishes	7998	Ictalurus punctatus (related: channel catfish)	Glycine dehydrogenase	reduced virulence	Gene deletion: partial	23762452
Z1_00620	BAA14327	65.3	404	2	133	1	401	1	400	6.450000000000001e-195	543.0	P25535	PHI:7028	ubiI	562	nan	Escherichia coli	UTI89	urinary tract infection	Rodents	10090	Mus musculus (related: house mouse)	Aerobic ubiquinone-8 synthase	reduced virulence	Gene mutation; gene complementation	27161114
Z1_00628	AJE56481	42.0	317	3	181	387	702	233	547	7.76e-68	231.0	A0A086VCI7	PHI:6912	ybtP	562	PHI:6912	Escherichia coli	UTI89	urinary tract infection	Rodents	10090	Mus musculus (related: house mouse)	ATP Binding Cassette Protein	reduced virulence	Gene mutation	26883590
Z1_00643	ADX36382	53.7	162	0	75	3313	3474	1394	1555	7.819999999999998e-48	189.0	F1CLH1	PHI:8498_PHI:6878	rtxA1	672	PHI:6876_PHI:8497	Vibrio vulnificus	CMCP6 ΔvvhA Rifr_CMCP6rif	vibriosis	Rodents	10090	Mus musculus (related: house mouse)	MARTX Cytotoxin	loss of pathogenicity_reduced virulence_unaffected pathogenicity_increased virulence (hypervirulence)	Gene deletion: full	28060924_30289477
Z1_00644	AAU27584	62.3	475	2	177	1	474	6	479	2.7600000000000004e-208	583.0	Q5ZVD8	PHI:6520	LpdA	446	nan	Legionella pneumophila	130b	legionnaires' disease	Rodents	10090	Mus musculus (related: house mouse)	Effector (plant avirulence determinant)	effector (plant avirulence determinant)	Gene deletion: full	26216420
Z1_00645	AAC45354	54.6	546	6	217	104	621	5	547	2.91e-158	464.0	Q59638	PHI:12232	aceF	287	PHI:12233_nan	Pseudomonas aeruginosa	PA14	nosocomial infection	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Dihydrolipoamide acetyltransferase	reduced virulence_unaffected pathogenicity	Gene deletion: full; gene complementation	35336241
Z1_00647	CAH19952	81.5	254	0	47	1	254	1	254	4.96e-145	404.0	Q66EI1	PHI:3135	pdhR	633	nan	Yersinia pseudotuberculosis	YPIII	gut-associated disease; diarrhea; enteritis; colitis	Rodents	10090	Mus musculus (related: house mouse)	Part of the pyruvate - tricarboxylic acid cycle node	reduced virulence	Gene disruption	25164818
Z1_00649	AJF38890	45.7	138	1	74	9	145	3	140	7.63e-36	119.0	A0A0U1YU94	PHI:6362	pilA	553	nan	Pantoea ananatis	LMG 20103	nan	Monocots	4679	Allium cepa (related: onion)	Twitching motility	reduced virulence	Gene mutation; gene complementation	27226224
Z1_00655	AE004855_10	43.4	122	0	69	38	159	2	123	7.46e-29	106.0	Q9HW06	PHI:10781	PA4400	287	nan	Pseudomonas aeruginosa	PAO1161	infection	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	Probable pyrophosphohydrolase	reduced virulence	Gene deletion: full; gene complementation	32419387
Z1_00658	AKJ44529	58.8	910	4	363	1	901	1	907	0.0	1023.0	A0A059ZR97	PHI:5240	secA	470	nan	Acinetobacter baumannii	ATCC 19606	nosocomial infection	Moths	7137	Galleria mellonella (related: greater wax moth)	Iron utilization	reduced virulence	Gene mutation; gene complementation	25605767
Z1_00661	ACC58837	51.2	297	1	144	2	298	1	296	1.63e-110	321.0	B2I1I9	PHI:10612	lpxC	470	nan	Acinetobacter baumannii	ATCC 19606	nosocomial infection	Primates	9606	Homo sapiens (related: human)	UDP-3-O-acyl-N-acetylglucosamine deacetylase	reduced virulence	Gene mutation; gene complementation	32373082
Z1_00669	AE004856_13	48.6	440	6	209	10	435	11	447	9.35e-118	350.0	Q9HVZ9	PHI:7631	murD	287	nan	Pseudomonas aeruginosa	PAO1	infection	Eudicots_Rodents	4236_10090	Lactuca sativa (related: garden lettuce)_Mus musculus (related: house mouse)	UDP-N-acetylmuramoylalanine--D-glutamate ligase	loss of pathogenicity_reduced virulence	Gene deletion: full	29045498
Z1_00671	AAG07804	43.9	433	9	230	29	454	24	450	6.68e-101	308.0	Q9HVZ7	PHI:7632	murF	287	nan	Pseudomonas aeruginosa	PAO1	infection	Eudicots_Rodents	4236_10090	Lactuca sativa (related: garden lettuce)_Mus musculus (related: house mouse)	Peptidyl-prolyl cis-trans isomerase	loss of pathogenicity_unaffected pathogenicity	Gene deletion: full	29045498
Z1_00675	BAB42274	42.8	313	6	166	6	311	2	308	1.88e-75	232.0	P60392	PHI:4961	rsmH	1280	nan	Staphylococcus aureus	RN4220	skin infection; food poisoning; respiratory disease	Moths	7091	Bombyx mori (related: domestic silkworm)	Ribosomal RNA small subunit methyltransferase H	reduced virulence	Gene deletion: full; gene complementation	25893373
Z1_00677	CRA_SALTY	83.2	334	0	56	1	334	1	334	6.36e-206	565.0	P0A2P8	PHI:2672	fruR	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028s	food poisoning	Rodents	10090	Mus musculus (related: house mouse)	Regulators of systemic infection	reduced virulence	Gene deletion: full; gene complementation	19229334
Z1_00679	AKO75949	48.8	295	2	148	19	312	20	312	4.97e-96	285.0	A0A0H6RQV7	PHI:7770	leuO	666	PHI:7771; PHI:7772; PHI:7773; PHI:7774; PHI:7775; PHI:7776	Vibrio cholerae	JB58 (Smr ΔlacZ)	cholera	Rodents	10090	Mus musculus (related: house mouse)	Leucine transcriptional activator	reduced virulence	Gene mutation	29304169
Z1_00680	ADN00061	74.0	524	1	131	1	519	1	524	4.05e-280	768.0	E0SG93	PHI:8578	leuA (Dda3937_04301)	204038	nan	Dickeya dadantii	3937	soft rot	Eudicots	13427	Cichorium intybus (related: chicory)	2-Isopropylmalate synthase	reduced virulence	Gene deletion: full	30267562
Z1_00681	AIT01852	78.2	362	0	79	1	362	1	362	2.25e-211	581.0	W9BCN0	PHI:8963	leuB	573	nan	Klebsiella pneumoniae	KPPR1	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	3-Isopropylmalate dehydrogenase	reduced virulence	Gene deletion: full	29712730
Z1_00682	AIT01851	83.8	463	0	75	1	463	1	463	1.79e-286	780.0	W9BBU8	PHI:8964	leuC	573	nan	Klebsiella pneumoniae	KPPR1	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	3-Isopropylmalate dehydratase large subunit	reduced virulence	Gene deletion: full	29712730
Z1_00683	AIT01850	78.2	197	0	43	3	199	4	200	3.11e-112	317.0	W9BQ45	PHI:8965	leuD	573	nan	Klebsiella pneumoniae	KPPR1	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	3-Isopropylmalate dehydratase small subunit	reduced virulence	Gene deletion: full	29712730
Z1_00688	AAC75974	81.8	302	0	55	5	306	3	304	2.48e-191	526.0	P60651	PHI:9150	speB	562	PHI:9151	Escherichia coli	APEC serotype O83:H4 ST117	colibacillosis	Birds	9031	Gallus gallus (related: chicken)	Agmatinase	reduced virulence_unaffected pathogenicity	Gene mutation	29519523
Z1_00690	MGG_00383	53.6	373	4	167	3	369	15	387	2.47e-135	390.0	G4NCL5	PHI:877	MGG_00383	318829	nan	Magnaporthe oryzae	KJ201	blast (rice)	Monocots	4530	Oryza sativa (related: rice)	Hypothetical protein	reduced virulence	Gene disruption	17353894
Z1_00694	ACY90746	54.7	850	5	365	21	857	13	855	0.0	945.0	D0ZKI3	PHI:4694	bcsA	28901	PHI:4693_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	cellulose synthesis regulation	increased virulence (hypervirulence)	Gene mutation	25848006
Z1_00706	ACT12748	82.4	550	0	97	1	550	1	550	0.0	941.0	C6DF39	PHI:10593	hcp	554	nan	Pectobacterium carotovorum	subsp. carotovorum strain PccS1	soft rot	Eudicots	3711_4097	Nicotiana tabacum (related: common tobacco)_Brassica rapa (related: field mustard)	Hydroxylamine reductase	unaffected pathogenicity	Gene deletion: full; gene complementation	32267092
Z1_00707	AAO53646	40.7	477	5	276	18	489	21	495	3.56e-120	360.0	Q88BC5	PHI:7787	AldA (PSPTO_0092)	317	PHI:7788_nan	Pseudomonas syringae	pv. tomato strain DC3000	bacterial speck (tomato)	Eudicots	3702	Arabidopsis thaliana (related: thale cress)	Indole-3-acetaldehyde dehydrogenase	reduced virulence	Gene disruption_Gene disruption; gene complementation	29293681
Z1_00713	AE004479_7	63.9	191	0	69	1	191	1	191	1.93e-90	261.0	Q9I690	PHI:3166	PA0423	287	nan	Pseudomonas aeruginosa	PAO1	nosocomial infection	Primates	9606	Homo sapiens (related: human)	factor responsible for cytotoxicity in lung epithelial cells	reduced virulence	Biochemical analysis_Gene mutation	25152458
Z1_00726	QHP58461	70.5	251	0	74	1	251	3	253	4.9e-125	353.0	A0A518VKX7	PHI:10587	kduD	554	nan	Pectobacterium carotovorum	subsp. carotovorum strain PccS1	soft rot	Monocots	69721	Zantedeschia aethiopica (related: arum-lily)	2-Dehydro-3-deoxy-D-gluconate 5-dehydrogenase	unaffected pathogenicity	Gene deletion: full; gene complementation	32267092
Z1_00739	BAB43211	40.9	279	2	160	1	276	1	277	7.56e-66	206.0	P99075	PHI:6903	FbaA	1280	nan	Staphylococcus aureus	USA300 JE2	white muscardine	Moths	7137	Galleria mellonella (related: greater wax moth)	Fructose-bisphosphate aldolase	reduced virulence	Functional test in host: direct injection	27001537
Z1_00741	AKO73834	52.6	196	1	92	9	204	7	201	2.31e-70	211.0	A0A0H6T2F5	PHI:6699	eda	666	nan	Vibrio cholerae	serotype O1 biovar El Tor strain N16961	cholera	 hares_Rabbits _Rodents	10090_9986	Oryctolagus cuniculus (related: rabbit)_Mus musculus (related: house mouse)	2-Keto-3-deoxy-6-phosphogluconate aldolase	reduced virulence	Gene mutation; gene complementation	27650573
Z1_00747	AAA25276	43.3	67	0	38	5	71	33	99	1.18e-12	58.2	Q56405	PHI:11287_PHI:7387	cadC_CadC	1639	PHI:7386_nan	Listeria monocytogenes	serotype 1/2a strain EGD-e_EGD-e	listeriosis	Rodents	10090	Mus musculus (related: house mouse)	Cadmium resistance transcriptional regulatory protein_Cadmium-dependent efflux pump regulator	reduced virulence_unaffected pathogenicity	Gene deletion: full; gene complementation_Gene mutation; gene complementation	28368435_31955655
Z1_00783	CAH21280	72.9	255	0	69	1	255	1	255	2.86e-119	340.0	Q66AT8	PHI:11908	znuB	632	PHI:11907; PHI:11909_PHI:11907; PHI:11909; PHI:11910	Yersinia pestis	glmS-pstS::kanR	pneumonic plague	Fleas_Rodents	163159_10090	Xenopsylla cheopis (related: oriental rat flea)_Mus musculus (related: house mouse)	Zinc transporter	reduced virulence	Gene deletion: full; gene complementation	34716262
Z1_00784	AAC74928	74.7	237	0	60	1	237	1	237	3.41e-129	363.0	P0A9X1	PHI:11007	znuC	562	PHI:11005; PHI:11006_nan	Escherichia coli	C83902	infection	Even-toed ungulates	9823	Sus scrofa (related: pig)	Zn(2(+)) ABC transporter ATP binding subunit	reduced virulence	Gene deletion: full	33028391
Z1_00785	CAL20696	58.9	321	4	117	1	310	1	317	2.16e-129	370.0	Q8ZEU2	PHI:11907	znuA	632	PHI:11911_PHI:11908; PHI:11909_PHI:11908; PHI:11909; PHI:11910	Yersinia pestis	glmS-pstS::kanR	pneumonic plague	Fleas_Rodents	163159_10090	Xenopsylla cheopis (related: oriental rat flea)_Mus musculus (related: house mouse)	Zinc transporter	reduced virulence	Gene deletion: full; gene complementation_Promoter mutation	34716262
Z1_00786	CAL20697	66.4	423	4	133	22	441	1	417	2.48e-197	551.0	Q0WF94	PHI:4185	ypo2062	632	nan	Yersinia pestis	CO92	bubonic plague	Rodents	10090	Mus musculus (related: house mouse)	putative DNA binding protein	reduced virulence	Gene deletion: partial; gene complementation	24675805
Z1_00791	AUY17561	71.4	112	0	32	1	112	1	112	1.34e-44	140.0	A0A1C1TY69	PHI:8966	mdtJ	573	nan	Klebsiella pneumoniae	KPPR1	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Multidrug transporter subunit	reduced virulence	Gene deletion: full	29712730
Z1_00792	ACI10803	70.1	107	0	32	4	110	3	109	1.07e-48	149.0	B5XR94	PHI:8967	mdtI	573	nan	Klebsiella pneumoniae	KPPR1	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Multidrug resistance protein	reduced virulence	Gene deletion: full	29712730
Z1_00796	AMY26905	54.9	233	0	105	1	233	1	233	2.9200000000000002e-86	254.0	A0A165G9C3	PHI:6870	yeaZ	669	nan	Vibrio harveyi	SF-1	luminous vibriosis	Bony fishes	7955	Danio rerio (related: zebrafish)	Resuscitation-promoting factor	reduced virulence	Gene disruption	27966258
Z1_00798	ABQ20123	71.1	553	1	159	1	552	1	553	4.6e-296	812.0	A5F6S0	PHI:4108	fadD	666	PHI:4109_nan	Vibrio cholerae	O395	cholera	 hares_Rabbits 	9986	Oryctolagus cuniculus (related: rabbit)	encoding a long-chain fatty acyl coenzyme A (acyl-CoA) ligase	reduced virulence_unaffected pathogenicity	Gene disruption	23918781
Z1_00800	ACD57940	51.2	84	2	39	1	84	1	82	2.59e-18	70.9	B2SRH1	PHI:123441	minE (PXO_04465)	347	PHI:123439; PHI:123440	Xanthomonas oryzae	pv. oryzae strain PXO99	bacterial leaf blight	Eudicots	4530_4097	Oryza sativa (related: rice)_Nicotiana tabacum (related: common tobacco)	Cell division topological specificity factor	reduced virulence_unaffected pathogenicity	Gene deletion: full; gene complementation	36013967
Z1_00801	ACD57941	67.4	270	1	87	1	270	1	269	1.62e-127	361.0	A0A0K0GI74	PHI:123440	minD (PXO_04464)	347	PHI:123439; PHI:123441_nan	Xanthomonas oryzae	pv. oryzae strain PXO99	bacterial leaf blight	Eudicots	4530_4097	Oryza sativa (related: rice)_Nicotiana tabacum (related: common tobacco)	Septum site-determining protein MinD	reduced virulence_unaffected pathogenicity	Gene deletion: full; gene complementation	36013967
Z1_00812	AAO57989	43.1	102	2	44	358	445	377	478	3.05e-14	73.6	Q87WK5	PHI:10942	PSPTO_4541	317	nan	Pseudomonas syringae	pv. tomato strain DC3000	bacterial speck	Eudicots	4081	Solanum lycopersicum (related: tomato)	Methyl-accepting chemotaxis protein	unaffected pathogenicity	Gene deletion: full; gene complementation	33029921
Z1_00830	ACY88258	56.5	317	3	135	1	317	1	314	1.34e-120	347.0	D0ZX10	PHI:3780	sssB	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	self-limiting gastroenteritis; typhoid-like disease (mice)	Rodents	10090	Mus musculus (related: house mouse)	Secreted effector protein	effector (plant avirulence determinant)	Gene mutation; gene complementation	23950998
Z1_00834	AAA87981	93.9	244	0	15	1	244	1	244	9.890000000000001e-166	456.0	P0A9E5	PHI:7248_PHI:4876	fnr_FNR	562	nan	Escherichia coli	CFT073_APEC O1	infection_colibacillosis	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	global regulator_Transcription factor, is a global regulator of pathways meant to facilitate gene expression	reduced virulence	Gene deletion: full; gene complementation_Gene mutation; gene complementation	25245807_28690981
Z1_00844	AAL19559	87.7	187	0	23	1	187	1	187	1.86e-127	354.0	P0A251	PHI:11383	ahpC	28901	PHI:11384	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028	salmonellosis	Moths	7137	Galleria mellonella (related: greater wax moth)	Peroxiredoxin	reduced virulence	Gene deletion: full	33732665
Z1_00860	AAZ36556	47.5	221	0	116	6	226	7	227	1.01e-74	224.0	Q48K32	PHI:6314	kdpE	317	nan	Pseudomonas syringae	MB03	bacterial speck	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	Potassium homeostasis and virulence	increased virulence (hypervirulence)	Gene mutation	27303387
Z1_00863	AE004591_3	58.2	677	7	257	15	685	33	689	1.65e-242	686.0	P57698	PHI:4712	kdpB	287	nan	Pseudomonas aeruginosa	PAO1-L	nosocomial infection	Nematodes_Rodents_Flies	7227_6239_10090	Caenorhabditis elegans (related: roundworm)_Drosophila melanogaster (related: fruit fly)_Mus musculus (related: house mouse)	Transport of small molecules	reduced virulence	Gene mutation	25845292
Z1_00870	no data found	75.2	799	3	195	14	811	7	803	0.0	1259.0	P45004	PHI:11664	dmsA	727	nan	Haemophilus influenzae	Hi2019	haemophilus influenzae disease	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Putative dimethylsulfoxide (DMSO) reductase, catalytic subunit	reduced virulence	Gene deletion: full; gene complementation	34367088
Z1_00930	AIK80567	47.6	248	3	126	3	247	1	247	1.8500000000000002e-72	220.0	A0A076ZHT9	PHI:7511	VK055_1961	573	PHI:7488; PHI:7489; PHI:7490; PHI:7476; PHI:7475; PHI:7477; PHI:7491; PHI:7492; PHI:7493; PHI:7494; PHI:7495; PHI:7496; PHI:7497; PHI:7498; PHI:7499; PHI:7500; PHI:7501; PHI:7502; PHI:7503; PHI:7504; PHI:7505; PHI:7506; PHI:7507; PHI:7508; PHI:7509; PHI:7510; PHI:7512	Klebsiella pneumoniae	KPPR1	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Serine 3-dehydrogenase	unaffected pathogenicity	Gene deletion: full	28861522
Z1_00939	AAL20389	83.6	463	0	76	1	463	1	463	5.2999999999999985e-285	776.0	Q8ZPL7	PHI:10048	fumC	28901	PHI:10046; PHI:10047; PHI:10051; PHI:10049_PHI:10046; PHI:10047; PHI:10051; PHI:10050_PHI:10046; PHI:10047; PHI:10050_PHI:10046; PHI:10047; PHI:10049_PHI:10046; PHI:10047; PHI:10051_PHI:10046; PHI:10047	Salmonella enterica	subsp. enterica serovar Typhimurium strain NCTC 12023	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Fumarate hydratase class II	reduced virulence	Gene mutation; gene complementation	31826974
Z1_00960	CAG59081	46.2	171	4	71	47	196	112	282	9.95e-36	125.0	Q6FUD7	PHI:12190	RIB1 (CAGL0F04279g)	5478	nan	Candida glabrata	KUE100-1	invasive candidiasis	Moths_Rodents	10090_7091	Bombyx mori (related: domestic silkworm)_Mus musculus (related: house mouse)	GTP cyclohydrolase-2	reduced virulence	Gene deletion: full	35308400
Z1_00965	AE004601_8	62.8	323	0	120	1	323	1	323	4.1e-143	405.0	G3XCU6	PHI:8764	cysB	287	nan	Pseudomonas aeruginosa	PAO1	infection	Rodents	10090	Mus musculus (related: house mouse)	LysR-type transcriptional regulator	reduced virulence	Gene deletion: full; gene complementation	30618115
Z1_00968	ACT14259	76.7	30	1	2	1	25	1	30	2.08e-08	45.4	C6DCT4	PHI:10597	hcp1	554	nan	Pectobacterium carotovorum	subsp. carotovorum strain PccS1	soft rot	Eudicots	3711_4097	Nicotiana tabacum (related: common tobacco)_Brassica rapa (related: field mustard)	Type VI secretion system effector, Hcp1 family	unaffected pathogenicity	Gene deletion: full; gene complementation	32267092
Z1_00969	AAB62385	52.9	172	0	81	3	174	5	176	2.76e-56	173.0	P0CW86	PHI:11378_PHI:9808	SodCI_sodCI	28901	nan_PHI:11379_PHI:9809	Salmonella enterica	subsp. enterica serovar Typhimurium strain LT2_subsp. enterica serovar Typhimurium strain ATCC 14028	salmonellosis	Moths_Rodents	7137_10090	Galleria mellonella (related: greater wax moth)_Mus musculus (related: house mouse)	Periplasmic superoxide dismutase_Superoxide dismutase [Cu-Zn] 1	reduced virulence_unaffected pathogenicity	Gene deletion: full_Gene deletion: full; gene complementation	30249808_33732665
Z1_00982	ACD57280	43.6	257	4	137	3	251	4	260	1.91e-54	181.0	B2SL03	PHI:9984	trpC (PXO_04004)	347	nan	Xanthomonas oryzae	pv. oryzae strain PXO99A	bacterial leaf blight	Monocots	4530	Oryza sativa (related: rice)	Indole-3-glycerol phosphate synthase	reduced virulence	Gene deletion: full; gene complementation	31847108
Z1_00983	CBA20869	83.6	396	0	65	1	396	1	396	8.66e-251	684.0	D4I3E6	PHI:9321	trpB	552	nan	Erwinia amylovora	HKN06P1	fire blight	Eudicots	3750	Malus domestica (related: apple)	Tryptophan synthase beta chain	reduced virulence	Gene mutation	31152019
Z1_00991	CAA48498	46.9	96	2	46	144	238	149	240	3.14e-23	92.8	P45610	PHI:6651	tonB	573	PHI:6652; PHI:6653_nan	Klebsiella pneumoniae	KPPR1	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	siderophores synthesis	reduced virulence_unaffected pathogenicity	Gene mutation	27624128
Z1_00993	AAL20657	69.8	486	0	147	1	486	1	486	1.29e-251	693.0	P63798	PHI:123208	clsA	28901	PHI:123209_PHI:123209; PHI:123210_nan_PHI:123210	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028s	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Cardiolipin synthase A	reduced virulence_unaffected pathogenicity	Gene deletion: full	35638781
Z1_01006	CAL20972	65.6	518	3	173	1	515	1	516	1.03e-238	664.0	Q0WEH7	PHI:4563	TyrR	632	nan	Yersinia pestis	201	plague	Rodents	10090	Mus musculus (related: house mouse)	regulator of aromatic amino acid metabolism	reduced virulence	Gene deletion: full; gene complementation	25729381
Z1_01011	ACY88506	48.2	114	1	58	5	118	7	119	6.05e-31	105.0	A0A0F6B1W9	PHI:7659	pspC	28901	PHI:7657; PHI:7658; PHI:7660_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ST4/74	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Phage-shock protein	reduced virulence_unaffected pathogenicity	Gene mutation; gene complementation	24713356
Z1_01012	ACY88507	66.7	75	1	23	1	75	1	73	1.28e-29	98.6	A0A0F6B1X0	PHI:7658	pspB	28901	PHI:7657; PHI:7659; PHI:7660_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ST4/74	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Phage-shock protein	reduced virulence	Gene mutation; gene complementation	24713356
Z1_01013	ACY88508	71.0	217	0	63	1	217	1	217	2.17e-97	281.0	A0A0F6B1X1	PHI:7657	pspA	28901	PHI:7658; PHI:7659; PHI:7660_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ST4/74	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Phage-shock protein	reduced virulence_unaffected pathogenicity	Gene mutation; gene complementation	24713356
Z1_01020	ABD30072	44.8	250	2	135	4	251	4	252	1.0200000000000001e-66	206.0	Q2FZQ3	PHI:7915	fabI	1280	PHI:7916_nan_PHI:7916; PHI:7917	Staphylococcus aureus	F-182_NCTC 13277_SAR17_Newman	reduced virulence_nan	Moths	7137	Galleria mellonella (related: greater wax moth)	Enoyl-ACP reductase	reduced virulence_unaffected pathogenicity	Gene mutation	29497096
Z1_01027	AAM85527	77.9	140	0	31	1	140	1	140	6.48e-70	205.0	P69988	PHI:6114	RovA	632	nan	Yersinia pestis	201	plague	Rodents	10090	Mus musculus (related: house mouse)	MarR-family regulator	reduced virulence	Gene deletion: full	26984293
Z1_01031	AFR93743	47.2	89	0	47	11	99	145	233	1.26e-24	92.0	J9VHR2	PHI:8615	Grx4 (CNAG_02950)	5207	nan	Cryptococcus neoformans	H99	meningoencephalitis	Rodents	10090	Mus musculus (related: house mouse)	Monothiol glutaredoxin	loss of pathogenicity	Gene deletion: partial; gene complementation	30514787
Z1_01036	AAL20353	80.2	192	0	38	1	192	1	192	6.520000000000001e-117	328.0	P0A2F4	PHI:11377	sodB	28901	PHI:11376_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028	salmonellosis	Moths	7137	Galleria mellonella (related: greater wax moth)	Cytoplasmic superoxide dismutase	reduced virulence_increased virulence (hypervirulence)	Gene deletion: full	33732665
Z1_01038	DQ778942	41.7	72	0	42	7	78	20	91	2.52e-07	49.7	Q0GPY7	PHI:3491	lhnR	373	nan	Agrobacterium vitis	F2/5	nan	Eudicots	29760	Vitis vinifera (related: wine grape)	Tobacco hypersensitive responses, grape necrosis	reduced virulence	Gene disruption; gene complementation	22212449
Z1_01040	CAM65755	49.5	386	6	171	17	378	96	481	6.74e-127	372.0	A4HTK3	PHI:2643	CFAS	5671	nan	Leishmania infantum	JPCM5	leishmaniasis	Rodents	10090	Mus musculus (related: house mouse)	Cyclopropane fatty acid synthetase	reduced virulence	Gene deletion: full; gene complementation	23251490
Z1_01045	ACY88150	84.5	470	0	73	1	470	1	470	3.79e-280	764.0	A0A0F6B0X2	PHI:10107	STM14_RS07745 (pykF)	28901	PHI:10099; PHI:10100; PHI:10101; PHI:10102; PHI:10103; PHI:10104; PHI:10105; PHI:10106; PHI:10108; PHI:10109; PHI:10110; PHI:10111; PHI:10112; PHI:10113; PHI:10114; PHI:10115; PHI:10116; PHI:10117; PHI:10118; PHI:10119; PHI:10120; PHI:10121; PHI:10122; PHI:10123; PHI:10124; PHI:10125; PHI:10126; PHI:10127; PHI:10128; PHI:10129; PHI:10130; PHI:10131; PHI:10132; PHI:10133; PHI:10134; PHI:10135; PHI:10136; PHI:10137; PHI:10138; PHI:10139; PHI:10140; PHI:10141; PHI:10142; PHI:10143; PHI:10144; PHI:10145; PHI:10146; PHI:10147; PHI:10148; PHI:10149; PHI:10150; PHI:10151; PHI:10152	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Pyruvate kinase I	reduced virulence	Gene deletion: full	32038592
Z1_01050	ACY88149	75.6	78	1	17	2	79	3	78	1.05e-18	71.2	A0A0F6B0X1	PHI:10106	STM14_RS07740 (lpp)	28901	PHI:10099; PHI:10100; PHI:10101; PHI:10102; PHI:10103; PHI:10104; PHI:10105; PHI:10107; PHI:10108; PHI:10109; PHI:10110; PHI:10111; PHI:10112; PHI:10113; PHI:10114; PHI:10115; PHI:10116; PHI:10117; PHI:10118; PHI:10119; PHI:10120; PHI:10121; PHI:10122; PHI:10123; PHI:10124; PHI:10125; PHI:10126; PHI:10127; PHI:10128; PHI:10129; PHI:10130; PHI:10131; PHI:10132; PHI:10133; PHI:10134; PHI:10135; PHI:10136; PHI:10137; PHI:10138; PHI:10139; PHI:10140; PHI:10141; PHI:10142; PHI:10143; PHI:10144; PHI:10145; PHI:10146; PHI:10147; PHI:10148; PHI:10149; PHI:10150; PHI:10151; PHI:10152	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Murein lipoprotein	reduced virulence	Gene deletion: full	32038592
Z1_01051	ACY88147	50.0	300	2	146	5	304	9	304	6.11e-98	290.0	A0A0F6B0W9	PHI:10104	STM14_RS07730 (ynhG)	28901	PHI:10099; PHI:10100; PHI:10101; PHI:10102; PHI:10103; PHI:10105; PHI:10106; PHI:10107; PHI:10108; PHI:10109; PHI:10110; PHI:10111; PHI:10112; PHI:10113; PHI:10114; PHI:10115; PHI:10116; PHI:10117; PHI:10118; PHI:10119; PHI:10120; PHI:10121; PHI:10122; PHI:10123; PHI:10124; PHI:10125; PHI:10126; PHI:10127; PHI:10128; PHI:10129; PHI:10130; PHI:10131; PHI:10132; PHI:10133; PHI:10134; PHI:10135; PHI:10136; PHI:10137; PHI:10138; PHI:10139; PHI:10140; PHI:10141; PHI:10142; PHI:10143; PHI:10144; PHI:10145; PHI:10146; PHI:10147; PHI:10148; PHI:10149; PHI:10150; PHI:10151; PHI:10152	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Murein L,D-transpeptidase	reduced virulence	Gene deletion: full	32038592
Z1_01052	ACY88146	52.8	127	0	60	3	129	1	127	2.3000000000000003e-43	138.0	A0A0F6B0W8	PHI:10103	STM14_RS07725 (ynhA/sufE)	28901	PHI:10099; PHI:10100; PHI:10101; PHI:10102; PHI:10104; PHI:10105; PHI:10106; PHI:10107; PHI:10108; PHI:10109; PHI:10110; PHI:10111; PHI:10112; PHI:10113; PHI:10114; PHI:10115; PHI:10116; PHI:10117; PHI:10118; PHI:10119; PHI:10120; PHI:10121; PHI:10122; PHI:10123; PHI:10124; PHI:10125; PHI:10126; PHI:10127; PHI:10128; PHI:10129; PHI:10130; PHI:10131; PHI:10132; PHI:10133; PHI:10134; PHI:10135; PHI:10136; PHI:10137; PHI:10138; PHI:10139; PHI:10140; PHI:10141; PHI:10142; PHI:10143; PHI:10144; PHI:10145; PHI:10146; PHI:10147; PHI:10148; PHI:10149; PHI:10150; PHI:10151; PHI:10152	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Cysteine desulfuration protein	reduced virulence	Gene deletion: full	32038592
Z1_01053	ACY88145	63.1	412	1	146	2	413	1	406	2.65e-184	516.0	A0A0F6B0W7	PHI:10102	STM14_RS07720 (sufS)	28901	PHI:10099; PHI:10100; PHI:10101; PHI:10103; PHI:10104; PHI:10105; PHI:10106; PHI:10107; PHI:10108; PHI:10109; PHI:10110; PHI:10111; PHI:10112; PHI:10113; PHI:10114; PHI:10115; PHI:10116; PHI:10117; PHI:10118; PHI:10119; PHI:10120; PHI:10121; PHI:10122; PHI:10123; PHI:10124; PHI:10125; PHI:10126; PHI:10127; PHI:10128; PHI:10129; PHI:10130; PHI:10131; PHI:10132; PHI:10133; PHI:10134; PHI:10135; PHI:10136; PHI:10137; PHI:10138; PHI:10139; PHI:10140; PHI:10141; PHI:10142; PHI:10143; PHI:10144; PHI:10145; PHI:10146; PHI:10147; PHI:10148; PHI:10149; PHI:10150; PHI:10151; PHI:10152	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Cysteine desulfurase	reduced virulence	Gene deletion: full	32038592
Z1_01054	ACY88144	51.5	412	5	194	24	432	10	418	3.82e-137	398.0	A0A0F6B0W6	PHI:10101	STM14_RS07715 (sufD)	28901	PHI:10099; PHI:10100; PHI:10102; PHI:10103; PHI:10104; PHI:10105; PHI:10106; PHI:10107; PHI:10108; PHI:10109; PHI:10110; PHI:10111; PHI:10112; PHI:10113; PHI:10114; PHI:10115; PHI:10116; PHI:10117; PHI:10118; PHI:10119; PHI:10120; PHI:10121; PHI:10122; PHI:10123; PHI:10124; PHI:10125; PHI:10126; PHI:10127; PHI:10128; PHI:10129; PHI:10130; PHI:10131; PHI:10132; PHI:10133; PHI:10134; PHI:10135; PHI:10136; PHI:10137; PHI:10138; PHI:10139; PHI:10140; PHI:10141; PHI:10142; PHI:10143; PHI:10144; PHI:10145; PHI:10146; PHI:10147; PHI:10148; PHI:10149; PHI:10150; PHI:10151; PHI:10152	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Fe-S cluster assembly protein	reduced virulence	Gene deletion: full	32038592
Z1_01055	APF09033	81.9	248	0	45	1	248	1	248	6.149999999999999e-147	409.0	A0A0M2J080	PHI:6894	sufC	28901	PHI:6892	Salmonella enterica	subsp. enterica serovar Typhimurium strain 12023	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Sulfur mobilization	unaffected pathogenicity	Gene mutation	27704705
Z1_01056	ACY88142	80.6	495	3	92	5	498	4	495	4.05e-293	799.0	A0A0F6B0W4	PHI:6893_PHI:10099	STM14_RS07705 (sufB)_sufB	28901	PHI:10100; PHI:10101; PHI:10102; PHI:10103; PHI:10104; PHI:10105; PHI:10106; PHI:10107; PHI:10108; PHI:10109; PHI:10110; PHI:10111; PHI:10112; PHI:10113; PHI:10114; PHI:10115; PHI:10116; PHI:10117; PHI:10118; PHI:10119; PHI:10120; PHI:10121; PHI:10122; PHI:10123; PHI:10124; PHI:10125; PHI:10126; PHI:10127; PHI:10128; PHI:10129; PHI:10130; PHI:10131; PHI:10132; PHI:10133; PHI:10134; PHI:10135; PHI:10136; PHI:10137; PHI:10138; PHI:10139; PHI:10140; PHI:10141; PHI:10142; PHI:10143; PHI:10144; PHI:10145; PHI:10146; PHI:10147; PHI:10148; PHI:10149; PHI:10150; PHI:10151; PHI:10152_PHI:6893	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s_subsp. enterica serovar Typhimurium strain 12023	salmonellosis_infection	Eudicots_Rodents	4236_10090	Lactuca sativa (related: garden lettuce)_Mus musculus (related: house mouse)	Sulfur mobilization_Fe-S cluster assembly protein	reduced virulence_unaffected pathogenicity	Gene deletion: full_Gene mutation	27704705_32038592
Z1_01059	AE005239_7	61.0	136	0	53	1	136	1	136	7.35e-55	167.0	Q8XBU9	PHI:6270	ybdB	562	nan	Escherichia coli	UTI89	urinary tract infection	Rodents	10090	Mus musculus (related: house mouse)	Proofreading thioesterase	lethal	Gene mutation	27073089
Z1_01067	CAH19580	55.5	650	5	279	33	680	35	676	9.15e-265	742.0	Q66FJ6	PHI:7905	hmuR	633	PHI:7906; PHI:7907; PHI:7908; PHI:7909	Yersinia pseudotuberculosis	IP2666	zoonotic infection	Even-toed ungulates	9940	Ovis aries (related: sheep)	Outer membrane hemin receptor	unaffected pathogenicity	Gene deletion: full	29520342
Z1_01068	CAH19579	62.9	345	2	121	1	345	1	338	3.3999999999999996e-151	427.0	Q66FJ7	PHI:7906	hmuS	633	PHI:7905; PHI:7907; PHI:7908; PHI:7909_PHI:7907; PHI:7908; PHI:7909	Yersinia pseudotuberculosis	IP2666	zoonotic infection	Even-toed ungulates	9940	Ovis aries (related: sheep)	Possible hemin degradation/transport protein	unaffected pathogenicity	Gene deletion: full	29520342
Z1_01069	CAH19578	55.2	268	1	119	5	271	10	277	5.26e-100	292.0	Q66FJ8	PHI:7907	hmuT	633	PHI:7905; PHI:7906; PHI:7908; PHI:7909_PHI:7906; PHI:7908; PHI:7909	Yersinia pseudotuberculosis	IP2666	zoonotic infection	Even-toed ungulates	9940	Ovis aries (related: sheep)	ABC transporter, periplasmic hemin-binding protein	unaffected pathogenicity	Gene deletion: full	29520342
Z1_01070	CAH19577	67.4	322	0	105	7	328	7	328	7.35e-144	408.0	Q66FJ9	PHI:7908	hmuU	633	PHI:7905; PHI:7906; PHI:7907; PHI:7909_PHI:7906; PHI:7907; PHI:7909	Yersinia pseudotuberculosis	IP2666	zoonotic infection	Even-toed ungulates	9940	Ovis aries (related: sheep)	Hemin import ATP-binding protein	unaffected pathogenicity	Gene deletion: full	29520342
Z1_01071	CAH19576	59.6	255	0	103	9	263	11	265	3.64e-105	304.0	Q66FK0	PHI:7909	hmuV	633	PHI:7906; PHI:7907; PHI:7908_PHI:7905; PHI:7906; PHI:7907; PHI:7908	Yersinia pseudotuberculosis	IP2666	zoonotic infection	Even-toed ungulates	9940	Ovis aries (related: sheep)	ABC hemin transporter, permease subunit	unaffected pathogenicity	Gene deletion: full	29520342
Z1_01074	ACY88406	54.3	468	1	213	1	468	1	467	1.36e-174	497.0	A0A0F6B1M0	PHI:7225	ydcR	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain SL1344	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Putative transcriptional regulator	reduced virulence	Gene deletion: full; gene complementation	28674150
Z1_01134	AAL19637	86.4	147	0	20	1	147	1	147	2.22e-96	273.0	Q7CQY3	PHI:11509	fur	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain SAT52	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Ferric uptake regulation protein	reduced virulence	Gene deletion: full; gene complementation	31383745
Z1_01153	AAA23893	76.8	125	0	29	1	125	5	129	2.22e-65	192.0	P69054	PHI:7962	sdhC	562	nan_PHI:7963; PHI:7964; PHI:7965	Escherichia coli	EDL933	urinary tract infection	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	Succinate dehydrogenase	reduced virulence	Gene mutation	29515100
Z1_01154	AAA23894	69.6	115	1	34	1	114	1	115	6.42e-50	152.0	P0AC44	PHI:7963	sdhD	562	PHI:7962; PHI:7964; PHI:7965_nan	Escherichia coli	EDL933	urinary tract infection	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	Succinate dehydrogenase	reduced virulence	Gene mutation	29515100
Z1_01155	AAA23895	92.0	588	0	47	1	588	1	588	0.0	1113.0	P0AC41	PHI:7964	sdhA	562	PHI:7966_PHI:7962; PHI:7963; PHI:7965_nan	Escherichia coli	EDL933	urinary tract infection	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	Succinate dehydrogenase flavoprotein subunit	reduced virulence	Gene mutation; gene complementation	29515100
Z1_01156	AAA23896	87.8	238	0	29	1	238	1	238	5.780000000000001e-163	448.0	P07014	PHI:7965	sdhB	562	PHI:7962; PHI:7963; PHI:7964_nan	Escherichia coli	EDL933	urinary tract infection	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	Succinate dehydrogenase iron-sulfur subunit	reduced virulence	Gene mutation	29515100
Z1_01158	ABD22597	42.9	431	12	200	5	401	3	421	1.55e-94	288.0	Q2FH26	PHI:7353	odhB	1280	nan	Staphylococcus aureus	JE2	skin infection; food poisoning; respiratory disease	Bony fishes	7955	Danio rerio (related: zebrafish)	Dihydrolipoamide succinyltransferase	unaffected pathogenicity	Gene mutation	28808156
Z1_01169	CAD17823	43.6	218	1	121	3	220	13	228	3.34e-50	162.0	Q3J038	PHI:10834	RSp0672	305	PHI:10833; PHI:10835; PHI:10836; PHI:10837; PHI:10838; PHI:10839; PHI:10840; PHI:10841; PHI:10842; PHI:10843; PHI:10844; PHI:10845; PHI:10846; PHI:10847; PHI:10848; PHI:10849; PHI:10850; PHI:10851; PHI:10852; PHI:10853_PHI:10833; PHI:10835; PHI:10836; PHI:10837; PHI:10838; PHI:10839_PHI:10833; PHI:10835; PHI:10836; PHI:10837; PHI:10838; PHI:10839; PHI:10840; PHI:10841; PHI:10842; PHI:10843; PHI:10844; PHI:10845; PHI:10846; PHI:10847; PHI:10848_PHI:10833; PHI:10835; PHI:10836; PHI:10837; PHI:10838; PHI:10839; PHI:10840; PHI:10841; PHI:10842; PHI:10843; PHI:10844; PHI:10845; PHI:10846; PHI:10847; PHI:10848; PHI:10849; PHI:10850; PHI:10851; PHI:10852; PHI:10853; PHI:10854; PHI:10855; PHI:10856; PHI:10857; PHI:10858; PHI:10859; PHI:10860; PHI:10861; PHI:10862; PHI:10863; PHI:10864; PHI:10865; PHI:10866; PHI:10867; PHI:10868; PHI:10869; PHI:10870; PHI:10871; PHI:10872_PHI:10833; PHI:10835; PHI:10836; PHI:10837; PHI:10838; PHI:10839; PHI:10840; PHI:10841; PHI:10842; PHI:10843; PHI:10844; PHI:10845	Ralstonia solanacearum	OE1-1	bacterial wilt	Eudicots	4100_4111	Solanum melongena (related: eggplant)_Nicotiana benthamiana (no common name found)(non-host bioassay)	Effector protein	effector (plant avirulence determinant)	Gene deletion: full	32849353
Z1_01171	AAG55075	54.4	90	1	40	267	355	305	394	1.63e-24	101.0	Q8X965	PHI:3472	TolA	562	nan	Escherichia coli	TW14359	infection	Moths	7137	Galleria mellonella (related: greater wax moth)	Periplasm spanning protein	reduced virulence	Gene mutation; gene complementation	25448467
Z1_01172	CBG87511	81.0	431	1	81	1	431	1	430	1.75e-156	447.0	D2TPE2	PHI:10905	tolB	67825	nan	Citrobacter rodentium	DBS100	colitis	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Colicin import protein	reduced virulence	Gene deletion: full	32968151
Z1_01179	CAD16367	62.5	352	1	129	1	349	1	352	2.59e-157	444.0	Q8XW15	PHI:8884	aroG1	305	PHI:8885_nan	Ralstonia solanacearum	OE1-1	bacterial wilt	Eudicots	4081_4097	Solanum lycopersicum (related: tomato)_Nicotiana tabacum (related: common tobacco)	Phospho-2-dehydro-3-deoxyheptonate aldolase	loss of pathogenicity	Gene deletion: full; gene complementation	30809210
Z1_01193	AAC23339	51.4	259	4	114	1	254	1	252	1.02e-77	234.0	P45323	PHI:5422	modA10	727	nan	Haemophilus influenzae	2866	nosocomial infection	Rodents	10114	Rattus (related: rat)	Phase-variable DNA methyltransferase	increased virulence (hypervirulence)	Gene mutation	26718097
Z1_01203	AE014259_2	57.7	659	3	272	5	663	10	661	1.03e-262	736.0	Q8DYL6	PHI:11576	uvrB	1311	nan	Streptococcus agalactiae	group B serotype V strain CNCTC 10/84	group b streptococcal infection	Primates	9606	Homo sapiens (related: human)	Excinuclease ABC, B subunit	unaffected pathogenicity	Gene deletion: full; gene complementation	32747604
Z1_01206	AAC73868	73.6	326	1	84	3	326	4	329	3.01e-182	504.0	P30745	PHI:10987	moaA	562	nan	Escherichia coli	PCN033	infection	Rodents	10090	Mus musculus (related: house mouse)	GTP 3',8-cyclase	unaffected pathogenicity	Gene deletion: full	32962530
Z1_01207	CCP45921	56.4	156	1	67	4	159	8	162	6.45e-47	149.0	P9WJR9	PHI:7748	rv3111	1773	PHI:7746; PHI:7747; PHI:7749; PHI:7750; PHI:7751; PHI:7752	Mycobacterium tuberculosis	H37Rv	tuberculosis	Rodents	10090	Mus musculus (related: house mouse)	Involved in hypoxia-responsive molybdenum cofactor biosynthesis	reduced virulence_unaffected pathogenicity	Gene deletion: full; gene complementation	29176894
Z1_01216	AE004813_4	54.8	394	3	173	4	393	3	395	4.94e-139	405.0	Q9HX66	PHI:11623_PHI:11622	RhlE1 (PA3950)_RhlE2 (PA0428)	287	PHI:11623_PHI:11622_nan	Pseudomonas aeruginosa	PAO1	infection	Moths	7137	Galleria mellonella (related: greater wax moth)	DEAD-box RNA helicase	reduced virulence	Gene deletion: full; gene complementation	34151378
Z1_01220	AAO68047	43.8	276	2	152	5	279	5	278	6.14e-79	239.0	Q8Z4N6	PHI:609_PHI:616	sseA	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain SL1344	gastroenteritis	Rodents	10090	Mus musculus (related: house mouse)	Type III secretion_nan	reduced virulence	Other evidence	16113260
Z1_01228	AAK88212	55.8	154	1	65	17	167	6	159	6.44e-55	169.0	Q8UCK6	PHI:10828	dps (atu2477)	358	nan	Agrobacterium tumefaciens	C58	crown gall	Eudicots	4113_23013	Solanum tuberosum (related: potato)_Kalanchoe daigremontiana (related: devil's backbone)	DNA protection during starvation protein	reduced virulence	Gene deletion: full; gene complementation	32678502
Z1_01246	BAD86762	82.4	193	0	34	1	193	1	193	1.12e-115	325.0	Q5KQZ9	PHI:2652	magA	573	nan	Klebsiella pneumoniae	NTUH-K2044	urinary tract infection; nosocomial pneumonia; abdominal infection	Rodents	10090	Mus musculus (related: house mouse)	Contributes to K1 capsular polysaccharide (CPS) biosynthesis	reduced virulence	Gene mutation: characterised	23118860
Z1_01249	AAO56193	45.1	246	1	133	1	244	5	250	4.11e-65	210.0	Q882D7	PHI:3118	PSPTO_2691	317	nan	Pseudomonas syringae	pv. tomato strain DC3000	bacterial speck (tomato)	Eudicots	4081_4097	Solanum lycopersicum (related: tomato)_Nicotiana tabacum (related: common tobacco)	Membrane protein, TerC family	unaffected pathogenicity	Gene mutation	25170934
Z1_01250	ATZ51660	53.0	451	3	208	7	454	11	460	1.38e-168	482.0	A0A384JMC8	PHI:9835	bcpgd	40559	nan	Botrytis cinerea	B05.10	grey mold	Eudicots	29760	Vitis vinifera (related: wine grape)	6-phosphogluconate dehydrogenase	reduced virulence	Gene deletion: full; gene complementation	31230563
Z1_01254	ABO13635	42.4	257	2	143	1	257	1	252	4.7199999999999986e-68	209.0	A3M9P1	PHI:10701	hisF (A1S_3245)	470	nan	Acinetobacter baumannii	ATCC 17978	pneumonia	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Imidazole glycerol phosphate synthase cyclase subunit	reduced virulence_unaffected pathogenicity	Gene deletion: full; gene complementation	32840575
Z1_01255	CBA21303	71.3	244	0	70	1	244	1	244	1.96e-123	349.0	D4HW76	PHI:9324	hisA	552	nan	Erwinia amylovora	HKN06P1	fire blight	Eudicots	3750_4097	Malus domestica (related: apple)_Nicotiana tabacum (related: common tobacco)	N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'-phosphoribosyl)-4-imidazolecarboxamide isomerase	reduced virulence_unaffected pathogenicity	Gene mutation	31152019
Z1_01257	AEQ96355	50.7	373	3	161	5	355	4	375	7.88e-132	380.0	G7TE30	PHI:7790	HisB	347	nan	Xanthomonas oryzae	pv. oryzicola strain RS105	bacterial blight (rice)	Monocots	4530	Oryza sativa (related: rice)	Bifunctional enzyme implicated in the imidazoleglycerol-phosphate dehydratase activity	reduced virulence	Gene deletion: full; gene complementation	29256829
Z1_01259	ACD58960	50.4	415	2	201	24	434	18	431	9.46e-133	387.0	A0A0K0GKU8	PHI:9983	hisD (PXO_00833)	347	nan	Xanthomonas oryzae	pv. oryzae strain PXO99A	bacterial leaf blight	Monocots	4530	Oryza sativa (related: rice)	Histidinol dehydrogenase	reduced virulence	Gene deletion: full; gene complementation	31847108
Z1_01260	CAR33649	86.6	299	0	40	1	299	1	299	2.3400000000000002e-181	500.0	B5QZL1	PHI:5109	prt	28901	nan	Salmonella enterica	subsp. enterica serovar Enteritidis strain P125109	colitis	Rodents	10090	Mus musculus (related: house mouse)	OAg biosynthesis	reduced virulence	Gene deletion: full; gene complementation	26346801
Z1_01263	AAY37538	40.4	193	1	114	1	192	1	193	2.02e-45	148.0	Q4ZTI4	PHI:7699	Smp	317	nan	Pseudomonas syringae	pv. syringae strain B728a	brown spot (bean)	Eudicots	3885	Phaseolus vulgaris (related: kidney bean)	Swarm motility-promoting regulatory protein	unaffected pathogenicity	Gene mutation; gene complementation	29066541
Z1_01282	ADX1663	56.4	360	1	155	7	364	6	365	3.89e-125	363.0	E8XCP9	PHI:3929	MacA	28901	PHI:3928	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028	food poisoning; enteritis	Rodents	10090	Mus musculus (related: house mouse)	ABC-Type Efflux Pump	reduced virulence	Gene deletion	24169575
Z1_01283	AAL19878	63.8	654	2	224	1	647	1	648	6.700000000000001e-281	781.0	Q8ZQE4	PHI:3928	MacB	28901	PHI:3929	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028	food poisoning; enteritis	Rodents	10090	Mus musculus (related: house mouse)	ABC-Type Efflux Pump	reduced virulence	Gene deletion	24169575
Z1_01284	ALZ72743	50.8	63	1	30	2	64	7	68	8.770000000000001e-21	75.9	A0A0U2P760	PHI:8636	CspA (WP_011258294.1)	347	nan	Xanthomonas oryzae	pv. oryzae strain PXO99	bacterial leaf blight	Monocots	4530	Oryza sativa (related: rice)	Cold-shock protein	reduced virulence	Gene deletion: full; gene complementation	30372574
Z1_01285	ADM98238	64.9	97	0	34	8	104	10	106	8.17e-44	136.0	E0SMW8	PHI:8568	clpS	204038	PHI:8569	Dickeya dadantii	3937	soft rot	Eudicots	13427	Cichorium intybus (related: chicory)	ATP-dependent Clp protease adapter protein	reduced virulence	Gene deletion: full	30267562
Z1_01286	ADM98239	80.7	758	3	135	1	755	1	750	0.0	1171.0	E0SMW9	PHI:8569	clpA (Dda3937_02363)	204038	PHI:8568	Dickeya dadantii	3937	soft rot	Eudicots	13427	Cichorium intybus (related: chicory)	ATP-dependent Clp protease ATP-binding subunit	reduced virulence	Gene deletion: full	30267562
Z1_01291	AY796185	49.5	321	8	142	6	313	2	315	3.63e-95	284.0	Q5RZ66	PHI:2846	TRR1	5207	nan	Cryptococcus neoformans	H99	nan	Lethal pathogen phenotype	Lethal pathogen phenotype	Lethal pathogen phenotype	Thioredoxin reductase	lethal	Altered gene expression / gene regulation	15701811
Z1_01292	CBJ89611	98.8	164	0	2	1	164	1	164	2.01e-113	317.0	D3VBH2	PHI:6497_PHI:7128	lrp	628	nan	Xenorhabdus nematophila	ATCC 19061	nan	Moths_Flies	7227_7130	Manduca sexta (related: tobacco hornworm)_Drosophila melanogaster (related: fruit fly)	Global Transcription Factor_Transcription factor	reduced virulence_increased virulence (hypervirulence)	Altered gene expression / gene regulation: downregulation_Altered gene expression / gene regulation: overexpression_Gene disruption_Gene mutation	26170407_28411220
Z1_01295	SAS94147	85.5	447	0	65	9	455	1	447	9.17e-279	759.0	A0A164J6A6	PHI:6447	rarA	573	PHI:6448; PHI:6449; PHI:6450	Klebsiella pneumoniae	NCTC 9633	pneumonia	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	Holliday junction DNA helicase	reduced virulence	Gene deletion: full	25193085
Z1_01301	MYN69560	43.8	767	9	396	8	756	15	764	7.82e-201	586.0	A0A6L8MWN2	PHI:123242	PFL (B9H01_RS01125)	1307	nan	Streptococcus suis	SC19	meningitis, endocarditis; sepsis	Moths	7137	Galleria mellonella (related: greater wax moth)	Formate C-acetyltransferase	reduced virulence	Gene mutation	35630313
Z1_01305	AAM36677	43.6	110	3	40	52	141	74	181	1.9e-16	80.5	Q8PLI3	PHI:5388	XacFhaB	346	nan	Xanthomonas citri	subsp. citri strain 99-1330	canker (citrus)	Eudicots	2711	Citrus sinensis (related: sweet orange)	Virulence factor/non-fimbrial adhesin protein	reduced virulence	Functional test in host: transient expression	26724481
Z1_01308	CNR65460	76.7	424	0	99	1	424	1	424	5.67e-235	646.0	A0A0U1G333	PHI:8755_PHI:7061	aroA	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s_subsp. enterica serovar Typhimurium strain BRD509	salmonellosis	Eukaryotes_Rodents	10090_44689	Dictyostelium discoideum (related: amoeba)_Mus musculus (related: house mouse)	3-Phosphoshikimate 1-carboxyvinyltransferase	reduced virulence_unaffected pathogenicity	Gene mutation	30574134_27456828
Z1_01310	FGSG_05002	41.6	77	3	37	196	264	229	305	1.82e-08	55.8	I1RM25	PHI:1579	GzOB019	5518	nan	Fusarium graminearum	GZ3639	fusarium ear blight	Monocots	4564	Triticum (related: wheat)	transcription factor	unaffected pathogenicity	Gene deletion	22028654
Z1_01311	IHFB_SALTY	88.2	93	0	11	1	93	1	93	1.5e-57	170.0	P64394	PHI:2673	himD	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028s	food poisoning	Rodents	10090	Mus musculus (related: house mouse)	Regulators of systemic infection	reduced virulence	Gene deletion: full; gene complementation	19229334
Z1_01326	AAC74012	65.4	182	0	63	1	182	1	182	1.24e-86	251.0	P0AB06	PHI:11001	ycbK	562	nan	Escherichia coli	PCN033	infection	Rodents	10090	Mus musculus (related: house mouse)	Peptidoglycan LD-endopeptidase	unaffected pathogenicity	Gene deletion: full	32962530
Z1_01331	OTE56952	48.7	1159	11	572	33	1182	31	1175	0.0	1053.0	A0A0L7AFE5	PHI:12052	icmF	562	nan	Escherichia coli	APEC O18	colibacillosis	Eukaryotes	44689	Dictyostelium discoideum (related: amoeba)	Type VI secretion system protein	unaffected pathogenicity	Gene deletion: full; gene complementation	35003930
Z1_01335	KF678350	64.4	908	5	313	1	906	1	900	0.0	1097.0	Q6TKU1	PHI:4559	T6SS2	562	PHI:4560	Escherichia coli	TW-XM	meningitis	Birds	8839	Anas platyrhynchos (related: mallard)	Type VI secretion systems (T6SSs) effectors	effector (plant avirulence determinant)	Gene mutation; gene complementation	24980972
Z1_01336	BAB33647	54.9	233	0	105	18	250	20	252	1.02e-88	261.0	Q8X7V4	PHI:12050	impK	562	nan	Escherichia coli	APEC O18	colibacillosis	Eukaryotes	44689	Dictyostelium discoideum (related: amoeba)	Type VI secretion system protein	unaffected pathogenicity	Gene deletion: full; gene complementation	35003930
Z1_01337	SHH56903	47.3	446	2	232	1	446	1	443	5.33e-147	425.0	A0A1M5U2L7	PHI:10596	impJ	554	nan	Pectobacterium carotovorum	subsp. carotovorum strain PccS1	soft rot	Eudicots	3711_4097	Nicotiana tabacum (related: common tobacco)_Brassica rapa (related: field mustard)	Type VI secretion system protein	unaffected pathogenicity	Gene deletion: full; gene complementation	32267092
Z1_01343	ARR32081	74.4	480	1	119	13	492	16	491	1.87e-277	759.0	A0A069FIK9	PHI:12051	evpB	562	nan	Escherichia coli	APEC O18	colibacillosis	Eukaryotes	44689	Dictyostelium discoideum (related: amoeba)	Type VI secretion system protein	unaffected pathogenicity	Gene deletion: full; gene complementation	35003930
Z1_01364	AAA83899	66.8	202	0	67	3	204	2	203	2.0699999999999998e-94	273.0	P08179	PHI:8652	purN	562	nan_PHI:8653	Escherichia coli	UTI89	infection	Rodents_Primates	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Phosphoribosylglycinamide formyltransferase	reduced virulence_unaffected pathogenicity	Gene deletion: full; gene complementation	30377949
Z1_01366	CAR43305	99.9	693	0	1	1	693	1	693	0.0	1364.0	B4EY92	PHI:5063	ppk	584	nan	Proteus mirabilis	HI4320	urinary tract infection	Rodents	10090	Mus musculus (related: house mouse)	Polyphosphate kinase	reduced virulence	Gene disruption; gene complementation	26233310
Z1_01374	CDN82752	75.1	1036	1	257	6	1041	6	1040	0.0	1481.0	W8ZK20	PHI:9198	yegN	562	PHI:9197_nan	Escherichia coli	serotype O157:H7 strain EDL933	urinary tract infection	Rodents	10090	Mus musculus (related: house mouse)	Multidrug efflux system subunit	reduced virulence	Gene deletion: full	31019555
Z1_01377	AAL23403	43.2	220	3	120	10	225	6	224	1.51e-52	168.0	Q8ZJU6	PHI:11268	creB	28901	PHI:11267_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028s	infection	Rodents	10090	Mus musculus (related: house mouse)	Response regulator in two-component regulatory system	reduced virulence	Gene deletion: full; gene complementation	33563986
Z1_01383	ABJ00040	51.6	161	2	76	53	212	26	185	4.09e-55	172.0	A0A0H2YXJ2	PHI:9385	pagP	562	PHI:9384	Escherichia coli	AE17	avian colibacillosis	Birds	9031	Gallus gallus (related: chicken)	Conserved hypothetical protein	reduced virulence_unaffected pathogenicity	Gene mutation; gene complementation	31326704
Z1_01386	CAL20379	81.0	121	0	23	1	121	1	121	1.9400000000000002e-71	208.0	Q7CHU5	PHI:8505	BfvR (YPO1737)	632	nan	Yersinia pestis	biovar Microtus strain 91001	pneumonic plague	Nematodes_Rodents	6239_10090	Caenorhabditis elegans (related: roundworm)_Mus musculus (related: house mouse)	AraC-family transcriptional regulator	reduced virulence_increased virulence (hypervirulence)	Gene deletion: full; gene complementation	30333962
Z1_01395	CBW17849	52.7	182	1	85	4	185	8	188	3.91e-60	184.0	A0A0H3NC59	PHI:9496	yeaB	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Rodents	10090	Mus musculus (related: house mouse)	RNA methyltransferase	reduced virulence	Gene mutation; gene complementation	31487966
Z1_01398	AEL04135	50.5	190	2	91	1	187	1	190	3.6700000000000004e-58	179.0	G1BJ13	PHI:7899	yebN	347	nan	Xanthomonas oryzae	pv. oryzae strain PXO99A	bacterial leaf blight	Monocots	4530	Oryza sativa (related: rice)	Leader RNA that functions as a sensor for Mn2+	reduced virulence	Gene deletion: partial; gene complementation	29522378
Z1_01411	AE004513_3	48.9	1051	14	484	92	1119	24	1044	5.81e-316	912.0	Q9I5F6	PHI:7999	putA	287	nan	Pseudomonas aeruginosa	PAK	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Bifunctional enzyme which converts proline to glutamate	reduced virulence	Gene deletion: full; gene complementation	29632523
Z1_01412	CCW30936	85.1	168	0	25	1	168	1	168	3.2600000000000003e-103	292.0	N1NKQ7	PHI:3922	FliZ	628	nan	Xenorhabdus nematophila	F1	nan	Moths	7109	Spodoptera littoralis (related: african cotton leafworm)	Global Regulatory Protein	reduced virulence	Gene mutation	24204316
Z1_01415	ACY84965	50.5	422	6	146	1	365	1	416	1.08e-88	271.0	D0Z9I9	PHI:2642	FliC	636	nan	Edwardsiella tarda	H1	edwardsiellosis	Bony fishes	7955	Danio rerio (related: zebrafish)	Flagellin Protein	reduced virulence	Gene deletion: full; gene complementation	23024793
Z1_01424	CAR43401	99.5	573	0	3	1	573	1	573	0.0	1068.0	B4EYL5	PHI:123276	fliF	584	nan	Proteus mirabilis	HI4320	urinary tract infection; urolithiasis	Primates	9606	Homo sapiens (related: human)	Flagellar M-ring protein	reduced virulence	Gene deletion	35651758
Z1_01427	AE004540_13	63.0	424	1	151	29	452	29	446	4.54e-176	499.0	Q9I4N1	PHI:6995	Flil	287	nan	Pseudomonas aeruginosa	PA14	opportunistic infection	Rodents	10090	Mus musculus (related: house mouse)	Flagellin	reduced virulence	Gene mutation	28246361
Z1_01428	AAA27102	45.9	146	1	78	1	146	1	145	5.250000000000001e-33	112.0	P0A1K1	PHI:6463	filj	28901	PHI:6464; PHI:6462_nan_PHI:6460; PHI:6462; PHI:6464	Salmonella enterica	subsp. enterica serovar Typhimurium strain IR715	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Flagellar protein	reduced virulence	Gene mutation	27435462
Z1_01436	TXE36820	59.6	255	0	103	1	255	1	255	5.6e-102	296.0	A0A5C7CFY5	PHI:12274_PHI:12273_PHI:12270_PHI:12269	FliR	615	nan	Serratia marcescens	RM66262_Db10	opportunistic infection	Flies	7227	Drosophila melanogaster (related: fruit fly)	Flagellar biosynthetic protein FliR	reduced virulence	Gene disruption; gene complementation	35197500
Z1_01439	AJF38888	42.6	544	3	308	5	546	4	545	9.999999999999999e-139	411.0	A0A0U1YUA0	PHI:6360	flgK	553	nan	Pantoea ananatis	LMG 20103	nan	Monocots	4679	Allium cepa (related: onion)	Flagellar motility	reduced virulence	Gene mutation; gene complementation	27226224
Z1_01452	AAO29937	40.0	55	0	33	82	136	128	182	1.76e-06	48.9	Q879S6	PHI:3659	HxfA (PD_2118) (pspA)	2371	nan	Xylella fastidiosa	Temecula1	pierce's disease of grapes; citrus variegated chlorosis	Eudicots	29760	Vitis vinifera (related: wine grape)	HL secreted protein, HxfA	increased virulence (hypervirulence)	Gene mutation	16134898
Z1_01453	AAL20829	76.3	695	2	161	1	694	1	692	0.0	1012.0	P40729	PHI:8731	flhA	28901	PHI:8727_PHI:8727; PHI:8728; PHI:8729	Salmonella enterica	subsp. enterica serovar Typhimurium strain SL1344	typhoid	Rodents	10090	Mus musculus (related: house mouse)	Flagellar biosynthesis protein	reduced virulence	Gene mutation	30379938
Z1_01454	AAC74950	56.5	382	2	164	1	381	1	381	6.6e-142	407.0	P76299	PHI:11174	flhB	562	nan	Escherichia coli	serotype O157:H7 strain EDL933	neonatal sepsis; neonatal meningitis	 hares_Rabbits _Primates	9986_9606	Homo sapiens (related: human)_Oryctolagus cuniculus (related: rabbit)	Flagellar biosynthetic protein 	reduced virulence	Gene deletion: full; gene complementation	33688013
Z1_01455	AAL20831	70.3	202	1	57	17	218	16	214	1.1e-94	274.0	P07800	PHI:10050	chez_cheZ	28901	PHI:10046; PHI:10047; PHI:10048; PHI:10051_PHI:10046; PHI:10047; PHI:10048	Salmonella enterica	subsp. enterica serovar Typhimurium strain NCTC 12023	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Protein phosphatase/ chemotactic response protein_Chemotaxis regulator protein	reduced virulence	Gene mutation; gene complementation	31826974
Z1_01456	AAL20832	82.2	129	0	23	1	129	1	129	5.13e-72	209.0	P0A2D5	PHI:10049_PHI:8732	cheY	28901	PHI:8727_PHI:8727; PHI:8728; PHI:8729_PHI:10046; PHI:10047; PHI:10048; PHI:10051_PHI:10046; PHI:10047; PHI:10048	Salmonella enterica	subsp. enterica serovar Typhimurium strain NCTC 12023_subsp. enterica serovar Typhimurium strain SL1344	typhoid_salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Chemotaxis regulator protein	reduced virulence	Gene mutation; gene complementation_Gene mutation	30379938_31826974
Z1_01457	AAL20833	76.6	350	1	81	1	350	1	349	2.25e-188	522.0	P04042	PHI:6461	cheB	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain IR715	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Chemotaxis	reduced virulence	Gene mutation	27435462
Z1_01458	AAL20834	61.1	285	1	110	5	289	1	284	5.36e-123	352.0	P07801	PHI:11916	cheR	28901	PHI:11917_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028s	infection	Rodents_Primates	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Chemotaxis protein methyltransferase	reduced virulence_increased virulence (hypervirulence)	Altered gene expression / gene regulation: overexpression_Gene deletion: full; gene complementation	34544273
Z1_01459	ACY90220	49.4	241	1	121	190	430	186	425	7.66e-38	145.0	A0A0F6B6S3	PHI:6985	mcpB	28901	PHI:6979; PHI:6980; PHI:6981; PHI:6982; PHI:6983; PHI:6984	Salmonella enterica	subsp. enterica serovar Typhimurium strain NCTC 12023	salmonellosis	Primates	9606	Homo sapiens (related: human)	Methyl-accepting chemotaxis protein	reduced virulence	Gene deletion: full	28212413
Z1_01460	ACY91777	50.9	568	3	264	1	568	1	553	1.62e-114	350.0	A0A0F6BB74	PHI:6981	tsr	28901	PHI:6979; PHI:6980; PHI:6982; PHI:6983_PHI:6979; PHI:6980; PHI:6982; PHI:6983; PHI:6984; PHI:6985_PHI:6979; PHI:6980_PHI:6979; PHI:6980; PHI:6982; PHI:6983; PHI:6984_PHI:6979; PHI:6980; PHI:6982	Salmonella enterica	subsp. enterica serovar Typhimurium strain NCTC 12023	salmonellosis	Primates	9606	Homo sapiens (related: human)	Methyl-accepting chemotaxis protein	reduced virulence	Gene deletion: full	28212413
Z1_01461	AAA23565	82.5	154	0	27	8	161	9	162	5.98e-82	238.0	P0A964	PHI:6536	cheW	562	PHI:6535	Escherichia coli	XM	meningitis	Birds	8839	Anas platyrhynchos (related: mallard)	Chemotaxis protein	unaffected pathogenicity	Gene mutation	26099584
Z1_01462	AAA23573	61.3	729	7	196	1	727	3	647	2.47e-282	788.0	P07363	PHI:6535	cheA	562	PHI:6536_nan	Escherichia coli	XM	meningitis	Birds	8839	Anas platyrhynchos (related: mallard)	Chemotaxis protein	reduced virulence_unaffected pathogenicity	Gene mutation	26099584
Z1_01463	AAA24178	61.1	270	1	103	7	274	8	277	5.729999999999999e-104	306.0	P0AF06	PHI:6534	motB	562	nan	Escherichia coli	XM	meningitis	Birds	8839	Anas platyrhynchos (related: mallard)	Motility protein	reduced virulence	Gene mutation	26099584
Z1_01464	AJF38889	68.8	292	0	91	1	292	1	292	2.48e-142	401.0	A0A0E9B8Z9	PHI:6361	motA	553	nan	Pantoea ananatis	LMG 20103	nan	Monocots	4679	Allium cepa (related: onion)	Flagellar motility	reduced virulence	Gene mutation; gene complementation	27226224
Z1_01465	ADM99088	82.3	186	1	32	1	186	1	185	2.23e-108	306.0	E0SIM9	PHI:8572	flhC (Dda3937_02784)	204038	PHI:8571	Dickeya dadantii	3937	soft rot	Eudicots	13427	Cichorium intybus (related: chicory)	Flagellar transcriptional activator	reduced virulence	Gene deletion: full	30267562
Z1_01466	AAC27633	80.2	116	0	23	1	116	4	119	1.7e-60	179.0	O85806	PHI:12272_PHI:12275_PHI:12276_PHI:12271	FlhD	615	nan	Serratia marcescens	RM66262_Db10	opportunistic infection	Flies	7227	Drosophila melanogaster (related: fruit fly)	Flagellar transcriptional regulator FlhD	unaffected pathogenicity	Gene disruption	35197500
Z1_01468	AAD16960	62.4	229	1	84	1	229	5	231	3.43e-89	261.0	D0ZLQ7	PHI:4698_PHI:3668_PHI:4693_PHI:9435_PHI:123167	mgtC_MgtC	28901	PHI:9434_PHI:9436_nan_PHI:4694	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s_subsp. enterica serovar Typhimurium strain ATCC 14028_subsp. enterica serovar Typhimurium strain ATCC 14028s	food poisoning_salmonellosis_gastroenteritis	Rodents	10090	Mus musculus (related: house mouse)	Virulence protein_cellulose synthesis regulation_Required for intramacrophage survival and growth in low Mg2+._Phosphate-specific transport system accessory protein PhoU	loss of pathogenicity_reduced virulence_effector (plant avirulence determinant)_increased virulence (hypervirulence)	Gene deletion: full_Gene mutation	25900124_25848006_35638741_23827679_31346161
Z1_01471	AAC06037	89.6	67	0	7	4	70	3	69	6.35e-41	126.0	P0A9Y9	PHI:7262	cspC	28901	PHI:7263_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain UMR1	salmonellosis	Rodents_Primates	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Cold shock protein	loss of pathogenicity_reduced virulence_unaffected pathogenicity	Gene deletion: full	28611217
Z1_01477	CBA20393	68.4	348	1	108	3	348	2	349	9.46e-181	503.0	D4I0W8	PHI:9307	pyrC	552	nan	Erwinia amylovora	HKN06P1	fire blight	Eudicots	3750	Malus domestica (related: apple)	Dihydroorotase	reduced virulence	Gene mutation	31152019
Z1_01480	ACY88155	69.1	1026	3	311	1	1026	1	1020	0.0	1461.0	A0A0F6B0X7	PHI:10113	STM14_RS07770 (ttrA)	28901	PHI:10099; PHI:10100; PHI:10101; PHI:10102; PHI:10103; PHI:10104; PHI:10105; PHI:10106; PHI:10107; PHI:10108; PHI:10109; PHI:10110; PHI:10111; PHI:10112; PHI:10114; PHI:10115; PHI:10116; PHI:10117; PHI:10118; PHI:10119; PHI:10120; PHI:10121; PHI:10122; PHI:10123; PHI:10124; PHI:10125; PHI:10126; PHI:10127; PHI:10128; PHI:10129; PHI:10130; PHI:10131; PHI:10132; PHI:10133; PHI:10134; PHI:10135; PHI:10136; PHI:10137; PHI:10138; PHI:10139; PHI:10140; PHI:10141; PHI:10142; PHI:10143; PHI:10144; PHI:10145; PHI:10146; PHI:10147; PHI:10148; PHI:10149; PHI:10150; PHI:10151; PHI:10152	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Tetrathionate reductase subunit A	reduced virulence	Gene deletion: full	32038592
Z1_01481	ACY88156	47.2	335	1	176	8	342	7	340	1.99e-110	323.0	A0A0F6B0X8	PHI:10114	STM14_RS07775 (ttrC)	28901	PHI:10099; PHI:10100; PHI:10101; PHI:10102; PHI:10103; PHI:10104; PHI:10105; PHI:10106; PHI:10107; PHI:10108; PHI:10109; PHI:10110; PHI:10111; PHI:10112; PHI:10113; PHI:10115; PHI:10116; PHI:10117; PHI:10118; PHI:10119; PHI:10120; PHI:10121; PHI:10122; PHI:10123; PHI:10124; PHI:10125; PHI:10126; PHI:10127; PHI:10128; PHI:10129; PHI:10130; PHI:10131; PHI:10132; PHI:10133; PHI:10134; PHI:10135; PHI:10136; PHI:10137; PHI:10138; PHI:10139; PHI:10140; PHI:10141; PHI:10142; PHI:10143; PHI:10144; PHI:10145; PHI:10146; PHI:10147; PHI:10148; PHI:10149; PHI:10150; PHI:10151; PHI:10152	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Tetrathionate reductase subunit C	reduced virulence	Gene deletion: full	32038592
Z1_01482	ACY88157	79.9	244	0	49	1	244	7	250	1.16e-151	421.0	A0A0F6B0X9	PHI:10115	STM14_RS07780 (ttrB)	28901	PHI:10099; PHI:10100; PHI:10101; PHI:10102; PHI:10103; PHI:10104; PHI:10105; PHI:10106; PHI:10107; PHI:10108; PHI:10109; PHI:10110; PHI:10111; PHI:10112; PHI:10113; PHI:10114; PHI:10116; PHI:10117; PHI:10118; PHI:10119; PHI:10120; PHI:10121; PHI:10122; PHI:10123; PHI:10124; PHI:10125; PHI:10126; PHI:10127; PHI:10128; PHI:10129; PHI:10130; PHI:10131; PHI:10132; PHI:10133; PHI:10134; PHI:10135; PHI:10136; PHI:10137; PHI:10138; PHI:10139; PHI:10140; PHI:10141; PHI:10142; PHI:10143; PHI:10144; PHI:10145; PHI:10146; PHI:10147; PHI:10148; PHI:10149; PHI:10150; PHI:10151; PHI:10152	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Tetrathionate reductase subunit B	reduced virulence	Gene deletion: full	32038592
Z1_01483	ACY88158	53.6	575	3	264	10	582	4	577	6.2e-205	583.0	A0A0F6B0Y0	PHI:10116	STM14_RS07785 (ttrS)	28901	PHI:10099; PHI:10100; PHI:10101; PHI:10102; PHI:10103; PHI:10104; PHI:10105; PHI:10106; PHI:10107; PHI:10108; PHI:10109; PHI:10110; PHI:10111; PHI:10112; PHI:10113; PHI:10114; PHI:10115; PHI:10117; PHI:10118; PHI:10119; PHI:10120; PHI:10121; PHI:10122; PHI:10123; PHI:10124; PHI:10125; PHI:10126; PHI:10127; PHI:10128; PHI:10129; PHI:10130; PHI:10131; PHI:10132; PHI:10133; PHI:10134; PHI:10135; PHI:10136; PHI:10137; PHI:10138; PHI:10139; PHI:10140; PHI:10141; PHI:10142; PHI:10143; PHI:10144; PHI:10145; PHI:10146; PHI:10147; PHI:10148; PHI:10149; PHI:10150; PHI:10151; PHI:10152	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Two-component system sensor histidine kinase	reduced virulence	Gene deletion: full	32038592
Z1_01484	no data found	63.9	83	0	30	1	83	1	83	4.68e-31	106.0	Q7CQM8	PHI:10117	STM14_RS07790 (ttrR)	28901	PHI:10099; PHI:10100; PHI:10101; PHI:10102; PHI:10103; PHI:10104; PHI:10105; PHI:10106; PHI:10107; PHI:10108; PHI:10109; PHI:10110; PHI:10111; PHI:10112; PHI:10113; PHI:10114; PHI:10115; PHI:10116; PHI:10118; PHI:10119; PHI:10120; PHI:10121; PHI:10122; PHI:10123; PHI:10124; PHI:10125; PHI:10126; PHI:10127; PHI:10128; PHI:10129; PHI:10130; PHI:10131; PHI:10132; PHI:10133; PHI:10134; PHI:10135; PHI:10136; PHI:10137; PHI:10138; PHI:10139; PHI:10140; PHI:10141; PHI:10142; PHI:10143; PHI:10144; PHI:10145; PHI:10146; PHI:10147; PHI:10148; PHI:10149; PHI:10150; PHI:10151; PHI:10152	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Two-component system response regulator	reduced virulence	Gene deletion: full	32038592
Z1_01486	ATM55433	64.4	306	0	109	1	306	1	306	1.12e-147	416.0	W9BFU2	PHI:7946	lpxL1 (BN49_2155)	573	nan_PHI:7947	Klebsiella pneumoniae	52.145	pneumonia	Moths	7137	Galleria mellonella (related: greater wax moth)	Lipid A late acyltransferase	reduced virulence_unaffected pathogenicity	Gene deletion: full; gene complementation	28652313
Z1_01493	FGSG_10069	46.3	54	1	28	105	158	587	639	5.48e-08	50.8	I1S053	PHI:1772	GzZC087	5518	nan	Fusarium graminearum	GZ3639	fusarium ear blight	Monocots	4564	Triticum (related: wheat)	transcription factor	reduced virulence	Gene deletion	22028654
Z1_01497	AAO90736	40.3	221	1	130	1	219	10	230	7.98e-55	173.0	Q83CA1	PHI:3599	PmrA	777	nan	Coxiella burnetii	Nine Mile Phase I	q fever	Primates	9606_9534	Homo sapiens (related: human)_Chlorocebus aethiops (related: grivet)	Response Regulator	reduced virulence	Gene mutation; gene complementation	24610709
Z1_01536	CAL11489	92.0	213	0	17	1	213	1	213	7.57e-137	380.0	A1JLB7	PHI:10469	RcsB (YE1397)	630	nan	Yersinia enterocolitica	nan	yersiniosis; acute gastroenteritis	Primates	9606	Homo sapiens (related: human)	Transcriptional regulatory protein	increased virulence (hypervirulence)	Gene deletion: full; gene complementation	32488337
Z1_01537	AAL21172	44.3	949	8	510	1	940	1	939	4.5399999999999995e-268	771.0	P58662	PHI:3011	rcsC11	28901	PHI:3013_PHI:3012_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	food poisoning	Rodents	10090	Mus musculus (related: house mouse)	Sensor protein	reduced virulence_unaffected pathogenicity_increased virulence (hypervirulence)	Gene mutation	15469511
Z1_01538	BAC98438	62.1	849	3	313	1	840	1	849	0.0	1044.0	Q75WC1	PHI:849	GyrA	337	nan	Burkholderia glumae	M3	bacterial grain rot	Monocots	4530	Oryza sativa (related: rice)	DNA gyrase (bacterial topoisomerase II)	chemistry target: sensitivity to chemical_chemistry target: resistance to chemical	Sequence analysis of sensitive and resistant strains_Gene mutation: characterised	15345450
Z1_01547	AE004841_2	77.3	475	1	107	13	486	3	477	1.22e-290	792.0	O52762	PHI:10648	katA	287	PHI:10647	Pseudomonas aeruginosa	PA14	opportunistic infection	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Catalase	unaffected pathogenicity	Altered gene expression / gene regulation: overexpression	32605982
Z1_01560	AE004693_4	65.9	164	1	55	1	163	1	164	1.69e-65	196.0	Q9I0J3	PHI:8938	nuoJ (PA2645)	287	PHI:8937_PHI:8939; PHI:8937_PHI:8937; PHI:8940; PHI:8941; PHI:8942; PHI:8943; PHI:8944; PHI:8945	Pseudomonas aeruginosa	PAO1	nosocomial infection	Eudicots_Moths	4236_7137	Galleria mellonella (related: greater wax moth)_Lactuca sativa (related: garden lettuce)	NADH-quinone oxidoreductase	reduced virulence_unaffected pathogenicity	Gene deletion: full; gene complementation	30804898
Z1_01561	AE004693_3	78.5	181	1	36	3	180	2	182	1.26e-90	261.0	Q9I0J4	PHI:8937	nuoI (PA2644)	287	PHI:8938; PHI:8940; PHI:8941; PHI:8942; PHI:8943; PHI:8944; PHI:8945_PHI:8938_PHI:8939; PHI:8938	Pseudomonas aeruginosa	PAO1	nosocomial infection	Eudicots_Moths	4236_7137	Galleria mellonella (related: greater wax moth)_Lactuca sativa (related: garden lettuce)	NADH-quinone oxidoreductase	reduced virulence_unaffected pathogenicity	Gene deletion: full; gene complementation	30804898
Z1_01563	AE004693_1	64.2	907	2	322	4	910	1	904	0.0	1155.0	Q9I0J6	PHI:11247	nuoG	287	nan	Pseudomonas aeruginosa	PAO1	nosocomial infection	Rodents	10090	Mus musculus (related: house mouse)	NADH dehydrogenase	unaffected pathogenicity	Gene deletion: full; gene complementation	33534802
Z1_01566	FG00376	42.6	385	2	215	217	598	87	468	7.88e-106	325.0	I1RA52	PHI:445	NOS1	5518	nan	Fusarium graminearum	PH-1	fusarium ear blight	Monocots	4577_4565	Triticum aestivum (related: bread wheat)_Zea mays (related: maize)	Ubiquinone oxidoreductase	reduced virulence	Gene disruption	18943005
Z1_01569	AE013766_1	69.2	286	0	88	1	286	1	286	8.419999999999998e-137	388.0	Q7CJ94	PHI:5089	RovM	632	nan	Yersinia pestis	KIM6+	bubonic plague	Fleas	163159	Xenopsylla cheopis (related: oriental rat flea)	LysR-Type Transcriptional Regulator	reduced virulence	Gene deletion: full; gene complementation	26348850
Z1_01570	ACD60708	43.2	389	0	221	9	397	14	402	1.38e-110	329.0	A0A0K0GPI8	PHI:9989	aspC (PXO_02420)	347	nan	Xanthomonas oryzae	pv. oryzae strain PXO99A	bacterial leaf blight	Monocots	4530	Oryza sativa (related: rice)	Aspartate aminotransferase	reduced virulence	Gene deletion: full; gene complementation	31847108
Z1_01576	EEO15930	72.1	398	3	107	3	399	2	396	1.8799999999999998e-207	574.0	A0A0H3Q0Y8	PHI:9843	ackA	666	PHI:9842_nan	Vibrio cholerae	SIO	infection	Flies	7227	Drosophila melanogaster (related: fruit fly)	Acetate kinase	unaffected pathogenicity	Gene deletion: full	30224439
Z1_01577	QPQ68955	83.3	713	1	118	1	712	1	713	0.0	1167.0	A0A8E6NAW3	PHI:123168	pta	28901	PHI:123169	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028s	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	phosphate acetyltransferase	loss of pathogenicity_reduced virulence	Gene deletion: full	35622226
Z1_01578	AAD07906	45.3	150	2	74	7	155	6	148	2.39e-42	138.0	O25531	PHI:11747	HP0860 (GmhB)	210	nan	Helicobacter pylori	26695	chronic gastritis	Primates	9606	Homo sapiens (related: human)	D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase	reduced virulence	Gene deletion: full; gene complementation	34125649
Z1_01580	AIK76292	41.6	209	3	117	11	217	25	230	3.4999999999999998e-40	135.0	R4ZAR0	PHI:11570	metP	1311	nan	Streptococcus agalactiae	group B serotype V strain CNCTC 10/84	group b streptococcal infection	Primates	9606	Homo sapiens (related: human)	Methionine permease	reduced virulence	Gene deletion: full; gene complementation	32747604
Z1_01585	CBG86980	40.3	233	5	123	3	220	2	233	7.01e-49	158.0	D2TI83	PHI:8514	nlpE	67825	PHI:8515_nan	Citrobacter rodentium	DBS100	colitis	Rodents	10090	Mus musculus (related: house mouse)	Outer-membrane lipoprotein	unaffected pathogenicity	Gene deletion: full_Gene deletion: full; gene complementation	30280092
Z1_01593	AF142597_1	46.2	210	3	104	60	267	56	258	1.1000000000000004e-59	188.0	Q9X6P4	PHI:3785	PA3644	287	nan	Pseudomonas aeruginosa	PAO1	infection	Beetles	7067	Tenebrio molitor (related: yellow mealworm)	acyltransferases	reduced virulence	Altered gene expression / gene regulation: overexpression	23848169
Z1_01594	EPT32247	47.9	142	2	71	4	143	85	225	6.51e-39	130.0	A0A125YY88	PHI:11972	fabZ (TGME49_321570)	5811	 	Toxoplasma gondii	RH_Prugniaud	toxoplasmosis	Rodents	10090	Mus musculus (related: house mouse)	Beta-hydroxyacyl-acyl carrier protein dehydratase	reduced virulence	Gene deletion: full	34531837
Z1_01595	AE004784_7	52.2	335	0	160	3	337	6	340	1.7599999999999998e-82	253.0	Q9HXY6	PHI:3784	PA3646	287	nan	Pseudomonas aeruginosa	PAO1	infection	Beetles	7067	Tenebrio molitor (related: yellow mealworm)	acyltransferases	reduced virulence	Altered gene expression / gene regulation: overexpression	23848169
Z1_01598	ACD59567	40.0	440	6	250	11	446	12	441	1.3599999999999998e-91	283.0	B2SR06	PHI:3895	PXO_01122	347	nan	Xanthomonas oryzae	pv. oryzae strain PXO99A	bacterial leaf blight	Monocots	4530	Oryza sativa (related: rice)	PDZ domain-containing proteases	reduced virulence	Gene disruption; gene complementation	24200074
Z1_01606	CBG86951	77.4	265	1	58	1	265	1	263	8.99e-155	430.0	D2TI55	PHI:9334	map	67825	nan	Citrobacter rodentium	DBS100	colitis	Rodents	10090	Mus musculus (related: house mouse)	Effector protein	effector (plant avirulence determinant)	Gene mutation	31251784
Z1_01612	ABX30516	47.7	509	8	227	1	470	1	509	2.78e-138	412.0	A8Z3D6	PHI:6309	glcB	1280	PHI:6308; PHI:6310; PHI:6311	Staphylococcus aureus	COL	skin infection; food poisoning; respiratory disease	Rodents	10090	Mus musculus (related: house mouse)	Glucose uptake protein	reduced virulence	Gene mutation; gene complementation	27329749
Z1_01629	ROZ92390	72.0	415	2	113	1	414	1	413	3.5300000000000005e-210	583.0	A0A380PMR4	PHI:9372	amiC	632	nan	Yersinia pestis	Kim53	bubonic plague	Rodents	10090	Mus musculus (related: house mouse)	N-acetylmuramoyl-L-alanine amidase	unaffected pathogenicity	Gene mutation	31170147
Z1_01644	AF116285_1	66.0	153	0	52	1	153	1	153	7.520000000000001e-79	230.0	Q9X4P2	PHI:7474	PA0336 (RppH)	287	nan	Pseudomonas aeruginosa	PAO1161	infection	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	Nudix-type RNA pyrophosphohydrolase	increased virulence (hypervirulence)	Gene mutation; gene complementation	28833678
Z1_01654	BAA34130	59.7	794	9	298	1	785	1	781	0.0	964.0	P31554	PHI:10312	LptD	562	nan	Escherichia coli	KP7600	urinary tract infection	Moths_Rodents	10090_7091	Bombyx mori (related: domestic silkworm)_Mus musculus (related: house mouse)	LPS-assembly protein	unaffected pathogenicity_increased virulence (hypervirulence)	Gene mutation	32324807
Z1_01657	ACT14650	77.4	265	0	60	1	265	1	265	1.01e-150	420.0	C6DEY6	PHI:10573	rsmA	554	nan	Pectobacterium carotovorum	subsp. carotovorum strain PccS1	soft rot	Monocots	69721	Zantedeschia aethiopica (related: arum-lily)	Ribosomal RNA small subunit methyltransferase A	unaffected pathogenicity	Gene deletion: full; gene complementation	32267092
Z1_01664	ABV16661	59.0	471	3	190	1	471	1	468	6.5e-209	584.0	A7ZRQ3	PHI:10978	sufI	562	nan	Escherichia coli	PCN033	infection	Even-toed ungulates_Rodents	9823_10036_10090	Mesocricetus auratus (related: golden hamster)_Sus scrofa (related: pig)_Mus musculus (related: house mouse)	Cell division protein	reduced virulence	Gene deletion: full	32962530
Z1_01665	EFY98917	41.8	165	4	90	66	225	102	265	9.81e-29	108.0	E9F1A7	PHI:6380	mrLPAAT1	568076	nan	Metarhizium robertsii	ARSEF 2575	nan	Moths_Beetles	7067_7091	Bombyx mori (related: domestic silkworm)_Tenebrio molitor (related: yellow mealworm)	Lysophosphatidate acyltransferase	reduced virulence	Gene mutation; gene complementation	27312218
Z1_01671	ACN32294	62.6	452	0	169	1	452	3	454	1.57e-184	523.0	C0LTR9	PHI:123409	tolC	562	nan	Escherichia coli	PPECC42	infection	Even-toed ungulates_Rodents	9823_10090	Sus scrofa (related: pig)_Mus musculus (related: house mouse)	tolerant colicin	reduced virulence	Gene deletion: full; gene complementation	36059454
Z1_01676	CNQ39570	71.1	83	0	24	1	83	1	83	2.06e-35	115.0	A0A0U1J4N7	PHI:6697	yqiC	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain SL1344	salmonellosis	Primates	9606	Homo sapiens (related: human)	Membrane fusogenic activity	reduced virulence	Gene disruption; gene complementation	27777572
Z1_01677	ACL32380	67.9	467	0	150	21	487	7	473	1.45e-227	632.0	B8F4X8	PHI:3147	rfaE	738	nan	Glaesserella parasuis	SC096	glasser's disease	Even-toed ungulates	9823	Sus scrofa (related: pig)	Part of cluster invloved in lipooligosaccharide synthesis	reduced virulence	Gene mutation	25078003
Z1_01717	AE004904_9	40.3	206	7	111	54	251	7	208	1.24e-36	128.0	Q9HUP7	PHI:4718	PA4916	287	nan	Pseudomonas aeruginosa	PAO1-L	nosocomial infection	Rodents_Flies	7227_10090	Drosophila melanogaster (related: fruit fly)_Mus musculus (related: house mouse)	unknown	reduced virulence	Gene mutation	25845292
Z1_01732	CAJ11717	40.1	424	7	235	2	420	5	414	7.81e-81	257.0	Q2YRY5	PHI:6684_PHI:9762	PykM (BAB1_1761)_pyk	29459_235	PHI:9763_nan	Brucella melitensis_Brucella abortus	2308	ovine brucellosis	Rodents	10090	Mus musculus (related: house mouse)	Manganese-Dependent Pyruvate Kinase_Pyruvate kinase	reduced virulence	Gene deletion: full; gene complementation_Gene mutation; gene complementation	30275278_27561260
Z1_01775	FGSG_09662	57.6	125	2	50	2	123	53	177	8.66e-43	137.0	I1RZ39	PHI:1599	GzOB039	5518	nan	Fusarium graminearum	GZ3639	fusarium ear blight	Monocots	4564	Triticum (related: wheat)	transcription factor	unaffected pathogenicity	Gene deletion	22028654
Z1_01781	CBA34185	59.2	250	1	97	1	245	1	250	3.36e-94	276.0	C9Y236	PHI:4583	FkpA	413502	nan	Cronobacter turicensis	LMG 23827	meningitis; bacteremia	Primates	9606	Homo sapiens (related: human)	virulence factor	reduced virulence	Gene mutation; gene complementation	25724920
Z1_01788	CAL35661	58.1	62	0	26	353	414	525	586	7.67e-14	72.8	Q0P864	PHI:4052	Cj1564	197	nan	Campylobacter jejuni	NCTC 11168-O	gastroenteritis	Birds	9031	Gallus gallus (related: chicken)	Chemoreceptor	unaffected pathogenicity	Gene mutation; gene complementation	24391495
Z1_01789	CAL34200	45.2	84	0	46	350	433	392	475	1.46e-14	75.1	Q0PCA6	PHI:11081	tlp10 (Cj0019c)	197	nan	Campylobacter jejuni	NCTC 11168-O	gastroenteritis	Birds_Primates	9031_9606	Homo sapiens (related: human)_Gallus gallus (related: chicken)	Putative MCP-domain signal transduction protein	reduced virulence	Gene deletion: full; gene complementation	33402336
Z1_01793	ACY90296	40.7	514	3	297	1	514	1	506	2.33e-114	346.0	A0A0F6B6Z9	PHI:6979	aer	28901	PHI:6980; PHI:6981; PHI:6982; PHI:6983_PHI:6980; PHI:6981; PHI:6982; PHI:6983; PHI:6984_nan_PHI:6980_PHI:6980; PHI:6981_PHI:6980; PHI:6981; PHI:6982; PHI:6983; PHI:6984; PHI:6985_PHI:6980; PHI:6981; PHI:6982	Salmonella enterica	subsp. enterica serovar Typhimurium strain NCTC 12023	salmonellosis	Primates	9606	Homo sapiens (related: human)	Methyl-accepting chemotaxis protein	reduced virulence	Gene deletion: full	28212413
Z1_01800	AE014000_4	98.6	210	0	3	1	210	1	210	1.02e-149	412.0	Q7CFV3	PHI:4063	Crp	632	nan	Yersinia pestis	CO92	pneumonic plague	Rodents	10090	Mus musculus (related: house mouse)	transcriptional regulator	reduced virulence	Gene mutation	24520064
Z1_01801	ACH49836	68.3	397	0	126	6	402	8	404	3.08e-202	561.0	B5F8I0	PHI:8863	ArgD	28901	PHI:8862_PHI:8860; PHI:8861; PHI:8862	Salmonella enterica	subsp. enterica serovar Agona strain Ag 1	infection	Rodents	10090	Mus musculus (related: house mouse)	Acetylornithine/succinyldiaminopimelate aminotransferase	reduced virulence	Gene mutation	30671294
Z1_01802	AAY47562	60.2	191	1	75	1	190	1	191	3.66e-81	238.0	Q4UZG1	PHI:3941	XC_0481	339	nan	Xanthomonas campestris	pv. campestris strain 8004	black rot	Eudicots	3726	Raphanus sativus (related: radish)	Anthranilate synthase component II	reduced virulence	Gene mutation	23819805
Z1_01803	ALD83590	75.4	167	0	41	21	187	22	188	1.4099999999999998e-89	259.0	A0A0D6I7L0	PHI:11417	ppiA	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Peptidyl-prolyl cis-trans isomerase	reduced virulence	Gene deletion: full	31111418
Z1_01808	CBG90603	61.8	207	0	79	1	207	1	207	4.4e-92	266.0	D2TUX9	PHI:8691	dsbA (ROD_38991)	67825	nan	Citrobacter rodentium	DBS100	colitis	Rodents	10090	Mus musculus (related: house mouse)	Thiol:disulfide interchange protein	loss of pathogenicity	Gene deletion: full; gene complementation	30536519
Z1_01809	CBG90604	52.5	326	2	153	6	331	5	328	7.67e-127	364.0	D2TUY0	PHI:8692	rdoA (ROD_39001)	67825	nan	Citrobacter rodentium	DBS100	colitis	Rodents	10090	Mus musculus (related: house mouse)	Putative regulatory protein kinase	unaffected pathogenicity	Promoter mutation	30536519
Z1_01811	AAX87890	43.2	183	2	102	6	186	5	187	8.68e-46	148.0	Q4QM57	PHI:5304	mobA	727	nan	Haemophilus influenzae	NTHI 2019	acute respiratory tract disease; chronic respiratory tract disease	Rodents	10090	Mus musculus (related: house mouse)	MobA protein catalyzes the final step in the synthesis of the molybdenum guanine dinucleotide (MGD) cofactor that is exclusive to enzymes of the DMSO reductase family.	unaffected pathogenicity	Gene mutation; gene complementation	26594204
Z1_01816	EEQ46193	49.0	482	11	209	3	449	36	515	5.85e-145	422.0	C4YR40	PHI:4904	Glr1	5476	nan	Candida albicans	nan	disseminated candidiasis	Moths_Rodents	7137_10090	Galleria mellonella (related: greater wax moth)_Mus musculus (related: house mouse)	Glutathione recycling enzymes/ glutathione reductase	reduced virulence	Gene disruption; gene complementation	26039593
Z1_01821	AE013987_5	49.2	476	2	240	1	475	1	475	7.44e-161	464.0	Q7CG15	PHI:4189	ypo3991	632	nan	Yersinia pestis	CO92	bubonic plague	Rodents	10090	Mus musculus (related: house mouse)	putative DNA binding protein	reduced virulence	Gene deletion: partial; gene complementation	24675805
Z1_01822	WP_004161053.1	42.5	226	2	123	4	225	2	224	1.63e-49	170.0	D4I4B4	PHI:8644_PHI:8642	pdeC_pdeA	552	PHI:8642; PHI:8643_nan_PHI:8643; PHI:8644_PHI:8642_PHI:8643	Erwinia amylovora	Ea1189	fire blight	Eudicots	3750_23211	Malus domestica (related: apple)_Pyrus communis (related: pear)	Phosphodiesterase	reduced virulence_unaffected pathogenicity	Gene mutation; gene complementation	30366999
Z1_01846	AKH09371	84.3	709	3	104	1	708	1	703	0.0	1182.0	A0A0D6I2I2	PHI:10548	spoT	28901	nan_PHI:10549	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	(P)ppGpp synthetase	reduced virulence_unaffected pathogenicity	Gene deletion: full_Gene mutation	32098823
Z1_01861	CAL18716	86.2	602	0	83	7	608	1	602	0.0	1040.0	A0A380PIP1	PHI:11030	bipA	632	nan	Yersinia pestis	CO92	pneumonic plague	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Putative GTPase	reduced virulence	Gene deletion: full; gene complementation	33257531
Z1_01862	AAL22846	82.7	468	0	81	1	468	1	468	8.829999999999999e-297	806.0	P0A1P6	PHI:7742	glnA	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain LT2	salmonellosis	Primates	9606	Homo sapiens (related: human)	Glutamine synthetase	reduced virulence	Gene deletion: full; chemical complementation	29150501
Z1_01863	AE004925_7	44.9	354	4	184	6	348	1	354	1.33e-90	274.0	Q9HU60	PHI:11699	ntrB	287	nan_PHI:11700	Pseudomonas aeruginosa	LESB58	opportunistic infection	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Histidine kinase	reduced virulence	Gene deletion: full; gene complementation	34249781
Z1_01864	AE004925_8	62.4	465	3	169	6	470	7	465	1.8699999999999998e-207	580.0	Q9HU59	PHI:11700	ntrC	287	nan_PHI:11699	Pseudomonas aeruginosa	LESB58	opportunistic infection	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	DNA-binding transcriptional regulator	reduced virulence	Gene deletion: full; gene complementation	34249781
Z1_01871	AAL22365	58.4	154	0	64	3	156	2	155	5.91e-57	174.0	Q8ZLJ2	PHI:7131	greB	28901	PHI:7130	Salmonella enterica	subsp. enterica serovar Typhimurium strain SV5015	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Transcription elongation factor	loss of pathogenicity	Gene mutation	28426789
Z1_01872	OMPR_SALTY	87.8	237	0	29	1	237	1	237	2.71e-155	429.0	P0AA19	PHI:2685	ompR	28901	PHI:2686	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028s	food poisoning	Rodents	10090	Mus musculus (related: house mouse)	Regulators of systemic infection	reduced virulence	Gene deletion: full; gene complementation	19229334
Z1_01873	ENVZ_SALTY	52.7	440	0	208	1	440	1	440	5.98e-166	473.0	P08982	PHI:2686	envZ	28901	PHI:2685	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028s	food poisoning	Rodents	10090	Mus musculus (related: house mouse)	Regulators of systemic infection	reduced virulence	Gene deletion: full; gene complementation	19229334
Z1_01877	AAM36442	66.1	248	0	84	11	258	20	267	1.16e-121	346.0	Q8PM59	PHI:3412	pstB	346	nan	Xanthomonas citri	subsp. citri strain 306	canker (citrus)	Eudicots	171249_2711	Citrus limonia (related: mandarin lime)_Citrus sinensis (related: sweet orange)	phosphate metabolism	loss of pathogenicity	Gene mutation	25403594
Z1_01878	QPQ67540	81.1	238	0	45	1	238	1	238	6.17e-142	395.0	A0A5W0R9X0	PHI:123166	phoU	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028s	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Phosphate-specific transport system accessory protein PhoU	loss of pathogenicity_reduced virulence	Gene mutation: characterised_Gene deletion: full_Gene mutation: characterised; gene deletion: full	35638741
Z1_01896	CBA24187	78.7	432	0	92	13	444	6	437	3.27e-238	656.0	D4I4J9	PHI:10919	EaAdeP (EAMY 3685)	552	nan	Erwinia amylovora	1189	fire blight	Eudicots	3750_23211	Malus domestica (related: apple)_Pyrus communis (related: pear)	Putative AzgA family transporter	reduced virulence	Gene mutation; gene complementation	33152083
Z1_01902	CRQ13186	67.2	777	6	243	1	776	1	766	0.0	994.0	A0A0F6UGK4	PHI:6941	feoB	287	PHI:6941_nan	Pseudomonas aeruginosa	PAO1	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Ferrous iron transport protein	loss of pathogenicity_increased virulence (hypervirulence)	Gene mutation; gene complementation	27271740
Z1_01910	AF220439_2	41.8	244	0	142	6	249	11	254	5.27e-72	219.0	Q9L7R1	PHI:6545	yihW	28901	PHI:6544	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	O-Antigen Capsule	unaffected pathogenicity	Gene deletion: full; gene complementation	26195553
Z1_01911	AE013994_1	79.0	496	2	102	1	496	29	522	3.4300000000000003e-296	808.0	Q8CWG4	PHI:3272	glpD	632	nan	Yersinia pestis	CO92	pneumonic plague	Rodents	10090	Mus musculus (related: house mouse)	Glycerol-3-phosphate dehydrogenase involved in glycerol fermentation	unaffected pathogenicity	Gene deletion: full; gene complementation	25220241
Z1_01913	CBA19083	80.5	297	0	58	1	297	1	297	2.06e-180	498.0	D4HUG0	PHI:9325	metF	552	nan	Erwinia amylovora	HKN06P1	fire blight	Eudicots	3750	Malus domestica (related: apple)	Methylenetetrahydrofolate reductase	unaffected pathogenicity	Gene mutation	31152019
Z1_01925	AAP56864	44.4	108	0	60	147	254	222	329	9.74e-23	95.1	Q7NAX1	PHI:7715	MGA_0220	2096	nan	Mycoplasma gallisepticum	Ap3AS	airsacculitis	Birds	9031	Gallus gallus (related: chicken)	Oligopeptide transporter ATP-binding protein OppD1	reduced virulence	Gene deletion: full; gene complementation	28348054
Z1_01928	CAR45801	99.6	525	0	2	1	525	1	525	0.0	1050.0	B4EZP9	PHI:123443	nikA	584	PHI:123444_PHI:123442_nan	Proteus mirabilis	HI4320	catheter-associated urinary tract infection	Rodents	10090	Mus musculus (related: house mouse)	ABC transporter. substrate-binding protein	reduced virulence_unaffected pathogenicity	Gene deletion: full	32255226
Z1_01934	BAC61949	41.5	53	0	31	221	273	209	261	4.39e-07	48.5	Q87IK0	PHI:8742	QsvR (VPA0606)	670	nan	Vibrio parahaemolyticus	RIMD 2210633	gastrointestinal disease	 hares_Rabbits _Primates_Rodents	10090_9986_9606	Homo sapiens (related: human)_Oryctolagus cuniculus (related: rabbit)_Mus musculus (related: house mouse)	Putative AraC-type regulatory protein	reduced virulence	Gene deletion: full; gene complementation	30623553
Z1_01955	ACY87774	74.1	286	1	73	8	292	7	292	3.19e-144	405.0	A0A0F6AZV0	PHI:11065	STM14_1285 (AsiR)	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Putative RpiR-family transcriptional regulator	increased virulence (hypervirulence)	Gene deletion: full; gene complementation	33410728
Z1_02000	CAD00621	51.1	354	2	169	8	358	4	356	7.05e-120	349.0	Q8Y4A8	PHI:9821	prfA (lmo2543)	1639	nan	Listeria monocytogenes	EGD-e	listeriosis	Primates	9606	Homo sapiens (related: human)	Peptide chain release factor 1	reduced virulence	Gene deletion: full	29715536
Z1_02004	CAG45307	55.4	314	4	135	3	313	4	315	1.74e-122	352.0	Q5NH02	PHI:4732	FTT0673p/prsAp	263	nan	Francisella tularensis	SCHU S4	tularemia	Rodents	10090	Mus musculus (related: house mouse)	ribose phosphate pyrophosphokinase	unaffected pathogenicity	Gene mutation	25999917
Z1_02019	AAO81010	47.4	544	3	279	9	551	5	542	3.83e-170	492.0	Q836A5	PHI:8543	AlsS	1351	nan	Enterococcus faecalis	JH2-2	nosocomial infection	Moths	7137	Galleria mellonella (related: greater wax moth)	α-Acetolactate synthase	reduced virulence	Gene deletion: full	30335810
Z1_02025	AAX64518	47.3	110	2	54	1	108	3	110	2.54e-32	108.0	Q57RZ3	PHI:5370	ramA	28901	nan	Salmonella enterica	subsp. enterica serovar Choleraesuis strain ATCC13312	bacteremia	Rodents	10090	Mus musculus (related: house mouse)	Transcriptional regulator	reduced virulence	Gene mutation	26608721
Z1_02028	ABR79228	42.5	120	2	67	4	123	2	119	2.9000000000000004e-21	81.3	A6TF94	PHI:7955	arnF	573	PHI:7949; PHI:7950; PHI:7951; PHI:7952; PHI:7953; PHI:7954	Klebsiella pneumoniae	52.145	pneumonia	Moths	7137	Galleria mellonella (related: greater wax moth)	Hypothetical protein	unaffected pathogenicity	Gene mutation	28652313
Z1_02029	ABR79229	50.0	100	1	48	10	109	11	108	7.27e-27	94.4	A6TF95	PHI:7954	arnE	573	PHI:7949; PHI:7950; PHI:7951; PHI:7952; PHI:7953; PHI:7955	Klebsiella pneumoniae	52.145	pneumonia	Moths	7137	Galleria mellonella (related: greater wax moth)	Hypothetical protein	unaffected pathogenicity	Gene mutation	28652313
Z1_02030	ABR79230	47.5	535	5	275	5	536	2	533	3.32e-175	504.0	A6TF96	PHI:7953	arnT	573	PHI:7949; PHI:7950; PHI:7951; PHI:7952; PHI:7954; PHI:7955	Klebsiella pneumoniae	52.145	pneumonia	Moths	7137	Galleria mellonella (related: greater wax moth)	4-Amino-4-deoxy-L-arabinose transferase	unaffected pathogenicity	Gene mutation	28652313
Z1_02031	ABR79231	62.7	295	1	109	1	295	1	294	7.59e-138	390.0	A6TF97	PHI:7952	arnD	573	PHI:7949; PHI:7950; PHI:7951; PHI:7953; PHI:7954; PHI:7955	Klebsiella pneumoniae	52.145	pneumonia	Moths	7137	Galleria mellonella (related: greater wax moth)	Hypothetical protein	unaffected pathogenicity	Gene mutation	28652313
Z1_02032	ABR79232	72.7	651	0	178	1	651	1	651	0.0	1013.0	A6TF98	PHI:7951	arnA	573	PHI:7949; PHI:7950; PHI:7952; PHI:7953; PHI:7954; PHI:7955	Klebsiella pneumoniae	52.145	pneumonia	Moths	7137	Galleria mellonella (related: greater wax moth)	Hypothetical protein	unaffected pathogenicity	Gene mutation	28652313
Z1_02033	ABR79233	76.1	314	0	75	1	314	1	314	5.13e-171	476.0	A6TF99	PHI:7950	arnC	573	PHI:7949; PHI:7951; PHI:7952; PHI:7953; PHI:7954; PHI:7955	Klebsiella pneumoniae	52.145	pneumonia	Moths	7137	Galleria mellonella (related: greater wax moth)	Putative sugar transferase	unaffected pathogenicity	Gene mutation	28652313
Z1_02034	ABR79234	66.5	376	0	126	1	376	1	376	1.6399999999999999e-189	527.0	A6TFA0	PHI:7949	arnB	573	PHI:7950; PHI:7951; PHI:7952; PHI:7953; PHI:7954; PHI:7955	Klebsiella pneumoniae	52.145	pneumonia	Moths	7137	Galleria mellonella (related: greater wax moth)	Putative aminotransferase	unaffected pathogenicity	Gene mutation	28652313
Z1_02050	ACY89872	65.3	285	0	99	18	302	15	299	1.1e-137	390.0	A0A0F6B5S8	PHI:10082	STM14_RS15345	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Manganese/iron ABC transporter ATP-binding protein	unaffected pathogenicity	Gene deletion: full	32038592
Z1_02051	ACY89873	65.0	266	1	84	10	275	6	262	9.59e-120	343.0	A0A0F6B5S9	PHI:10083	STM14_RS15350	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Iron ABC transporter permease	unaffected pathogenicity	Gene deletion: full	32038592
Z1_02052	ACY89874	67.3	275	0	90	5	279	4	278	5.96e-126	359.0	A0A0F6B5T0	PHI:10084	STM14_RS15355	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Iron ABC transporter permease	unaffected pathogenicity	Gene deletion: full	32038592
Z1_02053	ACY89875	54.8	259	0	117	9	267	7	265	3.2e-93	275.0	A0A0F6B5T1	PHI:10085	STM14_RS15360	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Putative inner membrane protein	unaffected pathogenicity	Gene deletion: full	32038592
Z1_02061	BAA00577	67.5	668	3	211	14	680	9	671	1.52e-317	877.0	P23865	PHI:9896	Prc	562	nan	Escherichia coli	RS218	urinary tract infection	Rodents	10090	Mus musculus (related: house mouse)	Tail-specific protease	reduced virulence	Gene mutation; gene complementation	31900139
Z1_02062	AAL20761	62.7	244	5	61	1	230	1	228	2.3999999999999997e-83	246.0	P60317	PHI:8783	ProQ	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain SL1344	salmonellosis	Rodents_Primates	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	RNA chaperone 	reduced virulence_unaffected pathogenicity	Gene mutation; gene complementation	30602583
Z1_02065	ACA68070	51.4	877	5	318	1	771	1	875	1.33e-313	878.0	A0A0H3B2K4	PHI:11187	MAM (YPK_1779)	633	nan	Yersinia pseudotuberculosis	YP126	zoonotic infection	Moths	7137	Galleria mellonella (related: greater wax moth)	Mammalian cell entry related domain protein	increased virulence (hypervirulence)	Gene deletion: full; gene complementation	33550901
Z1_02086	ACY88161	54.3	317	0	145	15	331	2	318	1.04e-129	371.0	A0A0F6B0Y3	PHI:10119	STM14_RS07800 (orf319)	28901	PHI:10099; PHI:10100; PHI:10101; PHI:10102; PHI:10103; PHI:10104; PHI:10105; PHI:10106; PHI:10107; PHI:10108; PHI:10109; PHI:10110; PHI:10111; PHI:10112; PHI:10113; PHI:10114; PHI:10115; PHI:10116; PHI:10117; PHI:10118; PHI:10120; PHI:10121; PHI:10122; PHI:10123; PHI:10124; PHI:10125; PHI:10126; PHI:10127; PHI:10128; PHI:10129; PHI:10130; PHI:10131; PHI:10132; PHI:10133; PHI:10134; PHI:10135; PHI:10136; PHI:10137; PHI:10138; PHI:10139; PHI:10140; PHI:10141; PHI:10142; PHI:10143; PHI:10144; PHI:10145; PHI:10146; PHI:10147; PHI:10148; PHI:10149; PHI:10150; PHI:10151; PHI:10152	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	DUF523 and DUF1722 domain-containing protein	reduced virulence	Gene deletion: full	32038592
Z1_02111	CAF25356	65.4	78	1	25	691	768	357	432	8.32e-22	97.4	P10858	PHI:7901	YadA	633	nan	Yersinia pseudotuberculosis	IP2666	zoonotic infection	Even-toed ungulates	9940	Ovis aries (related: sheep)	Adhesin	unaffected pathogenicity	Gene mutation	29520342
Z1_02119	ACL32202	69.2	39	0	12	962	1000	785	823	4.31e-10	62.4	B8F4F0	PHI:3319	gpT	738	nan	Glaesserella parasuis	LC	glasser's disease	Rodents	10090	Mus musculus (related: house mouse)	involved in pathogenicity	reduced virulence	Other evidence	25283960
Z1_02153	EHT98951	81.2	298	0	56	1	298	1	298	4.1e-178	492.0	H3RI38	PHI:3092	SoxR	66269	nan	Pantoea stewartii	subsp. stewartii strain DC283	stewart's wilt	Monocots	4577	Zea mays (related: maize)	activate gene expression in response to oxidative stress	reduced virulence	Gene mutation	24450773
Z1_02154	ABD20820.1	47.8	454	1	236	4	457	6	458	9.63e-143	415.0	Q2FIB5	PHI:2632	argH	1280	nan	Staphylococcus aureus	USA300 JE2	community-acquired infection; nosocomial infection	Rodents	10090	Mus musculus (related: house mouse)	Argininosuccinate lyase	reduced virulence	Gene disruption	23209408
Z1_02155	CBA19087	83.3	401	0	67	3	403	4	404	2.19e-250	683.0	D4HUG4	PHI:9316	argG	552	nan	Erwinia amylovora	HKN06P1	fire blight	Eudicots	3750	Malus domestica (related: apple)	Argininosuccinate synthase	reduced virulence	Gene mutation	31152019
Z1_02167	CBA19084	74.5	883	2	220	1	878	1	883	0.0	1319.0	D4HUG1	PHI:9322	ppc	552	nan	Erwinia amylovora	HKN06P1	fire blight	Eudicots	3750	Malus domestica (related: apple)	Phosphoenolpyruvate carboxylase	unaffected pathogenicity	Gene mutation	31152019
Z1_02171	CBA19080	69.2	386	0	119	1	386	1	386	7.01e-194	539.0	D4HUF7	PHI:9314	metB	552	nan	Erwinia amylovora	HKN06P1	fire blight	Eudicots	3750	Malus domestica (related: apple)	Cystathionine gamma-synthase	reduced virulence	Gene mutation	31152019
Z1_02172	CAG77150	91.4	105	0	9	1	105	1	105	5.75e-69	200.0	Q6CZA0	PHI:2695	metJ	29471	PHI:2694_nan	Pectobacterium atrosepticum	SCRI 1043	tuber rot; blackleg disease	Eudicots	4113	Solanum tuberosum (related: potato)	Repressor of the methionine biosynthesis regulon	reduced virulence	Gene mutation	23113713
Z1_02191	CBA19050	83.2	321	1	52	5	325	2	320	2.13e-198	545.0	D4HUC7	PHI:9309	pfkA	552	nan	Erwinia amylovora	HKN06P1	fire blight	Eudicots	3750	Malus domestica (related: apple)	ATP-dependent 6-phosphofructokinase	reduced virulence	Gene mutation	31152019
Z1_02195	CBG90541	55.7	106	2	41	73	176	42	143	1.28e-25	95.5	D2TU75	PHI:8515	cpxP	67825	PHI:8514_nan	Citrobacter rodentium	DBS100	colitis	Rodents	10090	Mus musculus (related: house mouse)	Periplasmic protein	unaffected pathogenicity	Gene deletion: full	30280092
Z1_02196	CBG90542	87.1	232	0	30	1	232	1	232	4.8e-143	397.0	D2TU76	PHI:8688_PHI:8512	cpxR	67825	PHI:8690; PHI:8689_PHI:8513_PHI:8689_nan	Citrobacter rodentium	DBS100	colitis	Rodents	10090	Mus musculus (related: house mouse)	Two-component response regulator	loss of pathogenicity_reduced virulence_unaffected pathogenicity	Gene deletion: full; gene complementation	30536519_30280092
Z1_02197	CBG90543	79.2	452	0	94	1	452	1	452	1.27e-266	729.0	D2TU77	PHI:8513_PHI:8689	cpxA	67825	PHI:8688_PHI:8690; PHI:8688_PHI:8512_nan	Citrobacter rodentium	DBS100	colitis	Rodents	10090	Mus musculus (related: house mouse)	Two-component sensor kinase	loss of pathogenicity_reduced virulence_unaffected pathogenicity	Gene deletion: full; gene complementation	30536519_30280092
Z1_02198	ACD59362	51.7	362	2	170	4	361	3	363	1.4699999999999998e-128	372.0	A0A0J9WXH4	PHI:6953	gigX1	347	nan	Xanthomonas oryzae	pv. oryzae strain PXO99A	bacterial leaf blight	Monocots	4530	Oryza sativa (related: rice)	Nucleotide sugar transaminase	increased virulence (hypervirulence)	Gene deletion: full; gene complementation	28213905
Z1_02222	ALE64165	50.7	418	2	200	13	430	16	427	8.540000000000001e-109	326.0	A0A0D6I3U0	PHI:5573	envC	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Determinants for intrinsic CAMP resistance	reduced virulence	Gene mutation	26810659
Z1_02228	AAL22571	70.5	312	0	92	3	314	2	313	5.769999999999998e-159	445.0	P26469	PHI:9594	rfaC	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain LT2	salmonellosis	Even-toed ungulates	9823	Sus scrofa (related: pig)	heptosyl transferase	reduced virulence	Gene mutation	31540295
Z1_02234	AE004911_8	51.4	418	3	200	5	420	5	421	2.65e-135	393.0	Q9HUH7	PHI:7635	waaA	287	nan	Pseudomonas aeruginosa	PAO1	infection	Eudicots_Rodents	4236_10090	Lactuca sativa (related: garden lettuce)_Mus musculus (related: house mouse)	3-deoxy-D-manno-octulosonic-acid (KDO) transferase	reduced virulence_unaffected pathogenicity	Gene deletion: full	29045498
Z1_02249	ADN00545	77.0	213	0	49	1	213	1	213	2.84e-119	336.0	E0SLM3	PHI:8576	pyrE (Dda3937_03258)	204038	nan	Dickeya dadantii	3937	soft rot	Eudicots	13427	Cichorium intybus (related: chicory)	Orotate phosphoribosyl transferase	reduced virulence	Gene deletion: full	30267562
Z1_02256	ABD22914	46.1	295	2	155	5	297	2	294	5.58e-89	266.0	Q2FK71	PHI:7350	murQ	1280	nan	Staphylococcus aureus	JE2	skin infection; food poisoning; respiratory disease	Bony fishes	7955	Danio rerio (related: zebrafish)	N-acetylmuramic acid-6-phosphate etherase	unaffected pathogenicity	Gene mutation	28808156
Z1_02295	BAA04222	61.8	526	1	200	3	527	2	527	5.05e-222	623.0	P42375	PHI:3085	GroEL	837	nan	Porphyromonas gingivalis	ATCC 33277	periodontitis	Rodents	10114	Rattus (related: rat)	folding of newly synthesized proteins, preventing misfolding and aggregation	increased virulence (hypervirulence)	Functional test in host: direct injection	25058444
Z1_02311	AAY50657	46.7	122	1	64	190	311	194	314	3.8200000000000005e-27	106.0	Q4UQL6	PHI:3957	XC_3615	339	nan	Xanthomonas campestris	pv. campestris strain 8004	black rot	Eudicots	3726	Raphanus sativus (related: radish)	Electron transfer flavoprotein alpha subunit	reduced virulence	Gene mutation	23819805
Z1_02317	CAE31262	40.0	250	6	141	13	261	19	260	7.66e-50	163.0	A0A0H3LHY6	PHI:10875	HK2 (BB0763)	139	nan	Borreliella burgdorferi	B31 A3	lyme disease	Rodents	10090	Mus musculus (related: house mouse)	Enoyl CoA dehydratase/isomerase	reduced virulence	Altered gene expression / gene regulation: overexpression_Gene mutation	33195322
Z1_02321	BAC96577	49.2	179	2	84	30	201	22	200	2.62e-58	189.0	Q7MEW9	PHI:5560	gbpA	672	nan	Vibrio vulnificus	MO6-24/O	vibriosis	Rodents	10090	Mus musculus (related: house mouse)	Mucin-Binding Protein	reduced virulence	Gene mutation	26755724
Z1_02332	CSB09787	48.3	89	1	45	84	172	1	88	1.55e-20	80.1	A0A0H6FRN3	PHI:6701	gntK	666	nan	Vibrio cholerae	serotype O1 biovar El Tor strain N16961	cholera	 hares_Rabbits _Rodents	10090_9986	Oryctolagus cuniculus (related: rabbit)_Mus musculus (related: house mouse)	Thermo-resistant gluconate kinase	reduced virulence	Gene mutation; gene complementation	27650573
Z1_02335	CBI66220	42.0	317	6	173	17	329	15	324	1.99e-62	200.0	D7FDG3	PHI:6849	niuD	210	nan	Helicobacter pylori	B128-S	gastric infection	Rodents	10090	Mus musculus (related: house mouse)	ABC transporter	reduced virulence	Gene deletion: full; gene complementation	27923069
Z1_02343	AIO83210	51.7	147	0	71	11	157	12	158	5.32e-52	162.0	A0A069B9Y9	PHI:5323	bicA	28450	nan	Burkholderia pseudomallei	DD503	melioidosis	Rodents	10090	Mus musculus (related: house mouse)	T3SS3 effector	effector (plant avirulence determinant)	Gene mutation	26583079
Z1_02344	CAH39007	40.0	340	1	203	1	339	1	340	5.61e-71	225.0	Q63K32	PHI:5324	bsaZ	28450	nan	Burkholderia pseudomallei	DD503	melioidosis	Rodents	10090	Mus musculus (related: house mouse)	T3SS3 effector	effector (plant avirulence determinant)	Gene mutation	26583079
Z1_02347	AFI69869	58.3	223	1	85	2	216	3	225	9.879999999999999e-82	241.0	A0A0H3HVR2	PHI:5325	spaP	28450	nan	Burkholderia pseudomallei	DD503	melioidosis	Rodents	10090	Mus musculus (related: house mouse)	T3SS3 effector	effector (plant avirulence determinant)	Gene mutation	26583079
Z1_02351	AAL21774	52.6	416	1	195	12	427	11	424	7.05e-149	428.0	P0A1B9	PHI:8301_PHI:645	invC	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s_subsp. enterica serovar Typhimurium strain SL1344	salmonellosis_gastroenteritis	Rodents	10090	Mus musculus (related: house mouse)	Salmonella pathogenicity island (SPI) 1 related protein; Probable ATP synthase_nan	reduced virulence_unaffected pathogenicity	Other evidence_Gene mutation	16113260_30072981
Z1_02353	AAO70359	50.8	691	4	324	10	699	10	685	1.62e-224	641.0	P0A1I4	PHI:647_PHI:9467	invA	28901	nan	Salmonella enterica	subsp. enterica serovar Typhi strain Ty2_subsp. enterica serovar Typhimurium strain SL1344	salmonellosis_gastroenteritis	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Invasion protein_nan	reduced virulence_unaffected pathogenicity	Other evidence_Gene deletion: full	16113260_31447308
Z1_02358	ACY89886	46.4	69	0	37	16	84	12	80	2.21e-12	55.5	A0A0F6B5U1	PHI:10094	STM14_RS15405 (prgI)	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Type III secretion system needle complex protein	unaffected pathogenicity	Gene deletion: full	32038592
Z1_02360	ACY89884	43.8	233	6	112	1	225	1	222	5.28e-45	150.0	A0A0F6B5T9	PHI:10092	STM14_RS15395 (prgK)	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Type III secretion system inner membrane ring lipoprotein	unaffected pathogenicity	Gene deletion: full	32038592
Z1_02364	EHT98350	55.0	149	0	67	1	149	1	149	7.520000000000001e-56	171.0	H3RJ93	PHI:3091	OxyR	66269	nan	Pantoea stewartii	subsp. stewartii strain DC283	stewart's wilt	Monocots	4577	Zea mays (related: maize)	activate gene expression in response to oxidative stress	unaffected pathogenicity	Gene mutation	24450773
Z1_02367	BAF66265	46.4	1008	2	529	1	1007	1	998	4.35e-311	887.0	A6P7G9	PHI:7771	vexB	666	PHI:7777; PHI:7772; PHI:7773; PHI:7774; PHI:7775; PHI:7776_PHI:7770; PHI:7772; PHI:7773; PHI:7774; PHI:7775; PHI:7776_PHI:7772; PHI:7773; PHI:7774; PHI:7775; PHI:7776	Vibrio cholerae	JB58 (Smr ΔlacZ)	cholera	Rodents	10090	Mus musculus (related: house mouse)	Multidrug efflux transporter	reduced virulence	Gene mutation	29304169
Z1_02384	CAN02728	43.4	53	0	30	16	68	19	71	2.64e-06	44.7	A5CUE1	PHI:3027	Vatr1	28447	nan	Clavibacter michiganensis	subsp. michiganensis strain NCPPB382	wilt (tomato); canker (tomato)	Eudicots	4081	Solanum lycopersicum (related: tomato)	TetR family of transcriptional regulators	reduced virulence	Gene disruption; gene complementation	24940988
Z1_02385	EWG54273	53.6	422	1	195	4	424	10	431	8.56e-161	458.0	W7MS09	PHI:3385	FVEG_12529	117187	nan	Fusarium verticillioides	M-3125	ear rot (maize); stalk rot (maize)	Monocots	4577	Zea mays (related: maize)	fusaric acid biosynthesis	unaffected pathogenicity	Gene deletion: full	25372119
Z1_02393	ACL32924	53.1	337	0	158	11	347	13	349	9.2e-130	373.0	B8F6H2	PHI:11189	potD	738	nan	Glaesserella parasuis	SC1401	glasser's disease	Even-toed ungulates_Rodents	9823_10090	Sus scrofa (related: pig)_Mus musculus (related: house mouse)	Polyamine transport protein	reduced virulence	Gene deletion: full; gene complementation	33525975
Z1_02396	AAL00050	53.1	288	3	127	9	294	4	285	2.59e-92	280.0	Q8DPC2	PHI:6319	potA	1313	PHI:6320; PHI:6321; PHI:6322	Streptococcus pneumoniae	serotype 4 strain TIGR4	pneumococcal pneumonia	Rodents	10090	Mus musculus (related: house mouse)	ABC transporter ATP-binding protein - spermidine/putrescine transport	reduced virulence	Gene mutation	27247105
Z1_02401	ABK38597	54.8	363	3	161	1	363	1	360	1.51e-132	382.0	A0KL98	PHI:11459	alr-2	644	nan	Aeromonas hydrophila	HBNUAh01	diarrhea; nausea; vomiting	Bony fishes_Rodents	7962_10090	Mus musculus (related: house mouse)_Cyprinus carpio (related: common carp)	Alanine racemase	reduced virulence	Gene deletion: full; gene complementation	30940083
Z1_02406	AAW74693	56.5	115	2	46	36	150	2	112	6.71e-40	133.0	Q5H2X8	PHI:2737	SSBX	347	PHI:2738_nan	Xanthomonas oryzae	pv. oryzicola strain RS105	leaf blight	Monocots	4530	Oryza sativa (related: rice)	Single-stranded DNA-binding protein	reduced virulence	Gene deletion: full_Gene deletion: full; gene complementation	23418541
Z1_02413	CBA23505	79.2	548	1	113	1	548	1	547	0.0	896.0	D4I2T0	PHI:9310	pgi	552	nan	Erwinia amylovora	HKN06P1	fire blight	Eudicots	3750	Malus domestica (related: apple)	Glucose-6-phosphate isomerase	reduced virulence	Gene mutation	31152019
Z1_02419	CAG74739	72.9	601	0	163	16	616	1	601	0.0	892.0	Q6D652	PHI:11150	edd	29471	nan	Pectobacterium atrosepticum	SCRI1039	soft rot (potato); blackleg disease (potato)	Eudicots	4113	Solanum tuberosum (related: potato)	Phosphogluconate dehydratase	unaffected pathogenicity	Gene deletion: full; gene complementation	33301200
Z1_02420	CAG75378	79.7	212	0	43	1	212	1	212	2.85e-121	341.0	Q6D4B5	PHI:11149	eda	29471	nan	Pectobacterium atrosepticum	SCRI1039	soft rot (potato); blackleg disease (potato)	Eudicots	4113	Solanum tuberosum (related: potato)	2-Keto-3-deoxy-6-phosphogluconate aldolase	reduced virulence	Gene deletion: full; gene complementation	33301200
Z1_02423	AAS91580_AY508881	46.7	508	8	259	21	522	23	524	1.85e-150	440.0	Q5J4D6	PHI:365_PHI:2267	Mls1_MLS1	13684	nan	Parastagonospora nodorum	SN15_nan	glume blotch	Monocots	4564	Triticum (related: wheat)	Malate synthase	loss of pathogenicity	Gene disruption; gene complementation	15306011
Z1_02424	CBA23513	73.8	309	0	81	1	309	1	309	1.87e-169	471.0	D4I2T4	PHI:9313	metA	552	nan	Erwinia amylovora	HKN06P1	fire blight	Eudicots	3750	Malus domestica (related: apple)	Homoserine O-succinyltransferase	reduced virulence	Gene mutation	31152019
Z1_02426	RMS74286	43.5	131	0	74	2	132	3	133	1.16e-36	123.0	A0A3M5LJ40	PHI:10966	idi	29438	PHI:10965_nan	Pseudomonas savastanoi	NCPPB 3335	knot (olive)	Eudicots	4146	Olea europaea (related: common olive)	Isopentenyl-diphosphate delta-isomerase	reduced virulence	Gene deletion: full; gene complementation	32973852
Z1_02440	CAJ12443	40.9	531	7	304	3	531	5	527	4.1499999999999985e-115	350.0	Q2YIV2	PHI:9126	bab2_0277	235	nan	Brucella abortus	2308	brucellosis	Rodents	10090	Mus musculus (related: house mouse)	choline dehydrogenase	reduced virulence	Gene disruption; gene complementation	29632093
Z1_02441	AIK80558	75.9	485	2	114	8	491	5	487	3.1299999999999997e-263	723.0	A0A076ZMY5	PHI:7520	VK055_1952	573	PHI:7513; PHI:7514; PHI:7515; PHI:7516; PHI:7517; PHI:7518; PHI:7519; PHI:7521; PHI:7522; PHI:7523; PHI:7524; PHI:7525; PHI:7526; PHI:7527; PHI:7528; PHI:7529; PHI:7530; PHI:7531; PHI:7532; PHI:7533; PHI:7534; PHI:7535; PHI:7536; PHI:7537; PHI:7538	Klebsiella pneumoniae	KPPR1	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Betaine aldehyde dehydrogenase	unaffected pathogenicity	Gene deletion: full	28861522
Z1_02442	ACT13587	69.3	192	0	59	9	200	1	192	5.019999999999998e-91	263.0	C6DKY6	PHI:10583	betL	554	nan	Pectobacterium carotovorum	subsp. carotovorum strain PccS1	soft rot	Monocots	69721	Zantedeschia aethiopica (related: arum-lily)	HTH-type transcriptional regulator 	unaffected pathogenicity	Gene deletion: full; gene complementation	32267092
Z1_02452	AAC66721	48.3	286	3	141	9	289	5	288	6.13e-85	258.0	H7C7L2	PHI:7821	oppF (bb0335)	139	PHI:7820	Borreliella burgdorferi	B31 5A18 NP1	lyme disease	Rodents	10090	Mus musculus (related: house mouse)	Oligopepeptide (Opp) transporter that drives transport by hydrolyzing ATP	reduced virulence	Gene mutation; chemical complementation	29259089
Z1_02453	AAC66722	47.0	279	2	145	9	284	6	284	4.05e-81	246.0	H7C7Q3	PHI:7820	oppD (bb0334)	139	PHI:7821	Borreliella burgdorferi	B31 5A18 NP1	lyme disease	Rodents	10090	Mus musculus (related: house mouse)	Oligopepeptide (Opp) transporter that drives transport by hydrolyzing ATP	reduced virulence	Gene mutation; chemical complementation	29259089
Z1_02456	CAJ12866	40.5	499	10	286	42	536	25	516	1.95e-114	348.0	Q2YKG0	PHI:9130	bab2_0700	235	nan	Brucella abortus	2308	brucellosis	Rodents	10090	Mus musculus (related: house mouse)	ABC transporter periplasmic binding protein	reduced virulence	Gene disruption; gene complementation	29632093
Z1_02467	CYV08090	45.2	876	10	451	9	871	20	879	3.9800000000000006e-251	723.0	A0A116Q7Z1	PHI:8932	adhE	1307	nan	Streptococcus suis	ZY05719	meningitis	Bony fishes_Primates	7955_9606	Homo sapiens (related: human)_Danio rerio (related: zebrafish)	Acetaldehyde-CoA/alcohol dehydrogenase	reduced virulence	Gene deletion: full	29247804
Z1_02469	CAA30530	77.0	135	1	30	1	134	1	135	1.86e-61	183.0	P0ACF8	PHI:6369	hns	562	nan	Escherichia coli	EDL933	urinary tract infection	Rodents	10090	Mus musculus (related: house mouse)	Global DNA-binding transcriptional dual regulator	increased virulence (hypervirulence)	Gene deletion: full	27173635
Z1_02471	AAM41468	48.8	297	3	143	6	301	3	291	2.58e-87	261.0	Q8P8Q1	PHI:3112	galU	339	nan	Xanthomonas campestris	pv. campestris strain 8004	black rot	Eudicots	3712	Brassica oleracea (no common name found)	Uridine triphosphate (UTP)-glucose-1-phosphate uridylyltransferase	loss of pathogenicity	Gene mutation: characterised; gene complementation	25033927
Z1_02472	Q7CQF1_SALTY	40.2	336	2	198	1	334	1	335	4.34e-84	256.0	Q7CQF1	PHI:2679	hnr	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028s	food poisoning	Rodents	10090	Mus musculus (related: house mouse)	Regulators of systemic infection	reduced virulence	Gene deletion: full; gene complementation	19229334
Z1_02485	AF349112_2	48.3	118	1	60	18	134	5	122	1.1e-35	119.0	P0A088	PHI:4582	msrB	1280	PHI:4579; PHI:4580; PHI:4581_nan	Staphylococcus aureus	SH1000	skin infection; food poisoning; respiratory disease	Rodents	10090	Mus musculus (related: house mouse)	Methionine Sulfoxide Reductase	reduced virulence_unaffected pathogenicity	Gene mutation; gene complementation	25680075
Z1_02486	CAB38645	47.5	337	6	167	1	331	1	333	2.47e-102	302.0	P0A038	PHI:6904	GAPDH	1280	nan	Staphylococcus aureus	USA300 JE2	white muscardine	Moths	7137	Galleria mellonella (related: greater wax moth)	Glyceraldehyde-3-phosphate dehydrogenase	reduced virulence	Functional test in host: direct injection	27001537
Z1_02488	HAD6865018	43.7	245	2	135	28	271	6	248	1.74e-73	223.0	A0A719CV62	PHI:123525	ompV	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain SL1344	salmonellosis	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	MipA/OmpV family protein	reduced virulence	Gene deletion: full; gene complementation	32017350
Z1_02489	ACY89848	54.7	762	9	315	3	763	7	739	9.33e-257	728.0	A0A0F6B5Q4	PHI:10063	STM14_RS15250	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Electron transport protein	unaffected pathogenicity	Gene deletion: full	32038592
Z1_02492	ABR77737	77.8	234	0	52	1	234	1	234	1.31e-132	372.0	A6TAW6	PHI:11407	gntR	573	nan	Klebsiella pneumoniae	ATCC 43816; MKP203	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Fatty acid metabolism regulator	reduced virulence	Gene deletion: full; gene complementation	31988174
Z1_02511	CCP43852	42.0	319	2	171	7	324	33	338	8.69e-75	233.0	P9WN21	PHI:6486_PHI:6487	GPM2_GLPX	1773	PHI:6487_PHI:6486_nan	Mycobacterium tuberculosis	H37Rv	tuberculosis	Rodents	10090	Mus musculus (related: house mouse)	Fructose bisphosphatase	loss of pathogenicity_unaffected pathogenicity	Gene deletion: full; gene complementation	26258286
Z1_02514	AAL20305	67.8	245	0	79	1	245	1	245	1.3800000000000002e-123	349.0	H9L4C4	PHI:611	orf245	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain SL1344	gastroenteritis	Rodents	10090	Mus musculus (related: house mouse)	nan	reduced virulence	Other evidence	16113260
Z1_02515	ACY88154	48.9	395	1	198	2	392	3	397	6.2599999999999996e-114	337.0	A0A0F6B0X6	PHI:10112	STM14_RS07765 (orf408)	28901	PHI:10099; PHI:10100; PHI:10101; PHI:10102; PHI:10103; PHI:10104; PHI:10105; PHI:10106; PHI:10107; PHI:10108; PHI:10109; PHI:10110; PHI:10111; PHI:10113; PHI:10114; PHI:10115; PHI:10116; PHI:10117; PHI:10118; PHI:10119; PHI:10120; PHI:10121; PHI:10122; PHI:10123; PHI:10124; PHI:10125; PHI:10126; PHI:10127; PHI:10128; PHI:10129; PHI:10130; PHI:10131; PHI:10132; PHI:10133; PHI:10134; PHI:10135; PHI:10136; PHI:10137; PHI:10138; PHI:10139; PHI:10140; PHI:10141; PHI:10142; PHI:10143; PHI:10144; PHI:10145; PHI:10146; PHI:10147; PHI:10148; PHI:10149; PHI:10150; PHI:10151; PHI:10152	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	DeoR family transcriptional regulator	reduced virulence	Gene deletion: full	32038592
Z1_02534	SEN1998	40.0	55	0	33	3	57	6	60	2.27e-08	45.1	A0A6C7HRI3	PHI:9805	rdf	28901	PHI:9804	Salmonella enterica	subsp. enterica serovar Dublin strain PT4	gastroenteritis	Rodents	10090	Mus musculus (related: house mouse)	Recombination Directionality Factor	reduced virulence	Gene deletion: full	31800631
Z1_02545	AFR98073	49.0	543	6	255	13	535	3	543	3.3700000000000005e-179	514.0	J9VUY6	PHI:6871	gua1	5207	nan	Cryptococcus neoformans	H99	fungal meningitis	Nematodes_Rodents	6239_10090	Caenorhabditis elegans (related: roundworm)_Mus musculus (related: house mouse)	GMP synthase	loss of pathogenicity	Gene deletion: full; gene complementation	28062578
Z1_02546	ADM99510	89.1	487	0	53	1	487	1	487	1.55e-304	827.0	E0SN64	PHI:8579	guaB (Dda3937_00004)	204038	nan	Dickeya dadantii	3937	soft rot	Eudicots	13427	Cichorium intybus (related: chicory)	IMP dehydrogenase	reduced virulence	Gene deletion: full	30267562
Z1_02548	ACU68762	44.7	745	6	404	9	749	13	753	5.4699999999999994e-216	624.0	C8CGJ2	PHI:10794	cjrC	562	nan	Escherichia coli	RS218	neonatal meningitis	Rodents_Primates	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	TonB-dependent colicin J protein	increased virulence (hypervirulence)	Gene mutation	32762693
Z1_02551	AJO87020	48.0	248	0	129	35	282	35	282	9.22e-78	236.0	A0A061L181	PHI:10792	cjrA	562	nan	Escherichia coli	RS218	neonatal meningitis	Rodents_Primates	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Iron-regulated protein	increased virulence (hypervirulence)	Gene mutation	32762693
Z1_02580	abd21287	62.2	331	2	123	1	330	1	330	8.210000000000001e-143	405.0	A0A0H2XHH2	PHI:2634	argF	1280	nan	Staphylococcus aureus	USA300 JE2	community-acquired infection; nosocomial infection	Rodents	10090	Mus musculus (related: house mouse)	Ornithine carbamoyltransferase	unaffected pathogenicity	Gene disruption	23209408
Z1_02594	ARA47379	86.4	331	0	45	1	331	1	331	1.0499999999999999e-216	592.0	A0A0W8AWM7	PHI:11411	yhbU	573	nan	Klebsiella pneumoniae	ATCC 43816; MKP203	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Ubiquinone biosynthesis protein	unaffected pathogenicity	Gene deletion: full; gene complementation	31988174
Z1_02596	CAA29156_AAC77276	47.0	287	4	144	25	310	21	300	5.78e-84	253.0	P08191	PHI:7846_PHI:9788_PHI:7180_PHI:11259_PHI:7204_PHI:2690_PHI:8107	FimH_fimH	562	nan_PHI:7845	Escherichia coli	H10407_F11_LF82_F149H1S2_CP9_RS218_UTI89	ascending pyelonephritis; urinary tract infection_urinary tract infection_pyelonephritis_crohn's disease_urinary tract infection; meningitis_salpingitis_neonatal meningitis	 hares_Rabbits _Birds_Rodents	9031_10090_9986	Gallus gallus (related: chicken)_Oryctolagus cuniculus (related: rabbit)_Mus musculus (related: house mouse)	Type 1 pilus-associated adhesin_Virulence factor_Type 1 pilus-associated mannose-binding adhesin_Type 1 fimbriae_Type 1 pilus_Type 1 fimbrin D-mannose specific adhesin_Adhesion_Adhesin which binds mannose with stereochemical specificity	reduced virulence_unaffected pathogenicity	Gene deletion: full_Gene mutation; gene complementation_Gene mutation: characterised_Gene deletion: full; gene complementation_Gene mutation	29311232_33513212_31767071_23358328_28545489_28808163_28531220
Z1_02597	ABW24958	53.3	165	1	76	5	169	2	165	2.93e-57	175.0	B0LF87	PHI:10212	fimG	573	nan	Klebsiella pneumoniae	TOP52	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Pilin (type 1 fimbria component protein)	unaffected pathogenicity	Gene deletion: full	29158434
Z1_02602	ABF06196	54.5	189	2	78	1	188	1	182	6.65e-57	176.0	Q0SXL9	PHI:9888	fimA	562	nan	Escherichia coli	JM103	infection	Primates	9606	Homo sapiens (related: human)	Major type 1 subunit fimbrin (Pilin)	unaffected pathogenicity	Gene disruption	29858013
Z1_02615	CAC98944	43.8	429	3	232	9	435	4	425	2.7199999999999997e-112	344.0	Q8Y8N0	PHI:7620_PHI:6510	Lmo0866_CshA	1639	PHI:7617; PHI:7618; PHI:7619_nan	Listeria monocytogenes	EGD-e	listeriosis	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	RNA Helicase_DExD-box RNA-helicase	unaffected pathogenicity_increased virulence (hypervirulence)	Gene deletion: full_Gene deletion: full; gene complementation_Gene mutation; gene complementation	25590644_26483402
Z1_02616	EAM_3066	79.4	296	3	58	1	295	1	294	4.66e-165	458.0	D4ICB6	PHI:2459	nlpI	552	nan	Erwinia amylovora	Ea1189	fire blight	Eudicots	23211	Pyrus communis (related: pear)	Tetratricopeptide lipoprotein	reduced virulence	Gene deletion: full; gene complementation	21831138
Z1_02617	AAL22154	83.9	700	0	113	1	700	1	700	0.0	1139.0	Q8ZLT3	PHI:3878	pnp	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain X4232	food poisoning	Even-toed ungulates	9823	Sus scrofa (related: pig)	polynucleotide phosphorylase, an exoribonuclease involved in RNA processing and degradation	reduced virulence	Gene mutation	24126127
Z1_02629	CAE50533	45.8	616	7	310	3	599	5	615	4.5900000000000006e-166	494.0	Q6NF92	PHI:11203	ftsH	1717	nan	Corynebacterium diphtheriae	NCTC 13129	diphtheria	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	ATP-dependent zinc metalloprotease	unaffected pathogenicity	Altered gene expression / gene regulation: overexpression	33672886
Z1_02632	AAL22169	84.2	158	0	25	1	158	1	158	1.4e-92	264.0	P64281	PHI:7130	greA	28901	PHI:7131	Salmonella enterica	subsp. enterica serovar Typhimurium strain SV5015	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Transcription elongation factor	loss of pathogenicity	Gene mutation	28426789
Z1_02641	ACR67684	76.9	312	0	72	1	312	1	312	1.22e-164	459.0	C5BF98	PHI:2959	mdh	67780	nan	Edwardsiella ictaluri	93-146	enteric septicemia	Bony fishes	7998	Ictalurus punctatus (related: channel catfish)	Malate dehydrogenase	reduced virulence	Gene deletion: partial	23762452
Z1_02650	EFE24562	60.5	613	0	242	661	1273	13	625	3.4300000000000004e-257	743.0	D4F0Q2	PHI:10715	tamB	636	nan	Edwardsiella tarda	TX01	edwardsiellosis	Bony fishes	244447	Cynoglossus semilaevis (related: tongue sole)	Autotransporter assembly complex proetin	reduced virulence	Gene deletion: full; gene complementation	32793174
Z1_02651	EFE24560	59.3	580	1	234	1	580	1	578	2.93e-264	733.0	D4F0Q0	PHI:10714	tamA	636	nan	Edwardsiella tarda	TX01	edwardsiellosis	Bony fishes	244447	Cynoglossus semilaevis (related: tongue sole)	Autotransporter assembly factor	reduced virulence	Gene deletion: full; gene complementation	32793174
Z1_02652	BAB42453	42.7	157	1	87	38	194	2	155	6.86e-35	120.0	P0A082	PHI:4579	msrA1	1280	PHI:4580; PHI:4581; PHI:4582_PHI:4580; PHI:4581_nan	Staphylococcus aureus	SH1000	skin infection; food poisoning; respiratory disease	Rodents	10090	Mus musculus (related: house mouse)	Methionine Sulfoxide Reductase	reduced virulence	Gene mutation; gene complementation	25680075
Z1_02657	ABA25866	43.5	115	2	53	103	205	2	116	5.97e-18	74.7	Q2LK92	PHI:548_PHI:2305	BcFKBP12_BcPIC5	40559	nan	Botrytis cinerea	B05.10_T4	grey mold	Eudicots	3885_3603_4081_3659_3750	Cucumis sativus (related: cucumber)_Vitis (no common name found)_Phaseolus vulgaris (related: kidney bean)_Solanum lycopersicum (related: tomato)_Malus domestica (related: apple)	Unknown_Rapamycin sensitivity	reduced virulence_unaffected pathogenicity_increased virulence (hypervirulence)	Gene disruption; gene complementation_Gene deletion: partial	19116175_16497329
Z1_02658	EAT92394	52.8	483	3	219	2	481	7	483	7.59e-174	496.0	Q0V515	PHI:3914	Sdh1	13684	nan	Parastagonospora nodorum	SN15	stagonospora nodorum blotch	Monocots	4565	Triticum aestivum (related: bread wheat)	encodes succinic semialdehyde dehydrogenase	reduced virulence	Gene disruption; gene complementation	24265684
Z1_02659	BBD29223	48.3	176	0	91	40	215	336	511	2.39e-53	177.0	A0A2Z6BW49	PHI:12225	adcA	1351	PHI:12226; PHI:12227; PHI:12228_PHI:12226; PHI:12227_PHI:12228_nan	Enterococcus faecalis	OG1RF	nosocomial infection	Moths_Rodents	7137_10090	Galleria mellonella (related: greater wax moth)_Mus musculus (related: house mouse)	ABC-type transporter	reduced virulence_unaffected pathogenicity	Gene deletion: full; gene complementation	35341449
Z1_02669	ARF52028	71.6	141	1	38	1	141	1	139	4.26e-69	203.0	H3RHG9	PHI:12252	nsrR	66269	nan	Pantoea stewartii	subsp. stewartii	stewart's wilt; leaf blight (maize)	Monocots	4577	Zea mays (related: maize)	DNA-binding transcriptional regulator	unaffected pathogenicity	Gene deletion: full; gene complementation	35237242
Z1_02670	AAL23186	85.2	432	0	64	1	432	1	432	9.61e-280	760.0	P65882	PHI:9416_PHI:2625	purA	28901	PHI:2622_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain NCTC S12023_subsp. enterica serovar Typhimurium strain SL1344	food poisoning_gastroenteritis	Bony fishes_Rodents	7955_10090	Danio rerio (related: zebrafish)_Mus musculus (related: house mouse)	Adenylosuccinate synthetase_Pathogenicity island	loss of pathogenicity_reduced virulence	Gene mutation: characterised_Gene mutation	31428591_23236281
Z1_02674	CAL19055	88.5	87	1	9	1	87	1	86	1.12e-47	145.0	Q8ZIW2	PHI:4064	Hfq	632	nan	Yersinia pestis	CO92	pneumonic plague	Rodents	10090	Mus musculus (related: house mouse)	RNA-binding protein	reduced virulence	Gene mutation	24520064
Z1_02685	AE004908_2	69.1	178	0	55	3	180	2	179	2.74e-87	252.0	P57665	PHI:6274	Orn	287	nan	Pseudomonas aeruginosa	PA14	opportunistic infection	Rodents	10090	Mus musculus (related: house mouse)	Oligoribonuclease	reduced virulence	Gene mutation	27296966
Z1_02691	AUU95694	40.4	156	5	82	25	172	40	192	8.03e-22	85.9	A0A0S3FFR9	PHI:10207	fimA	573	nan	Klebsiella pneumoniae	TOP52	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Fimbrial protein	unaffected pathogenicity	Gene deletion: full	29158434
Z1_02698	CAD90950	42.9	375	8	194	50	419	19	378	5.02e-86	265.0	Q83XM0	PHI:4976	LssD	446	PHI:4975	Legionella pneumophila	Paris	legionnaires' disease	Eukaryotes	5755	Acanthamoeba castellanii (no common name found)	Functional Type 1 Secretion System	reduced virulence	Gene disruption	25422301
Z1_02700	AAC73786	82.8	429	0	74	15	443	7	435	5.2799999999999994e-256	701.0	P0AAF1	PHI:9154	potE	562	nan	Escherichia coli	APEC serotype O83:H4 ST117	colibacillosis	Birds	9031	Gallus gallus (related: chicken)	nan	unaffected pathogenicity	Gene mutation; gene complementation	29519523
Z1_02701	AAC76002	67.9	719	2	223	1	719	1	711	0.0	1015.0	P21169	PHI:9151	speC	562	PHI:9150	Escherichia coli	APEC serotype O83:H4 ST117	colibacillosis	Birds	9031	Gallus gallus (related: chicken)	Constitutive ornithine decarboxylase	reduced virulence_unaffected pathogenicity	Gene mutation	29519523
Z1_02719	AJF38891	54.1	331	1	151	1	331	1	330	2.68e-115	335.0	A0A0U1YU79	PHI:6363	pilT	553	nan	Pantoea ananatis	LMG 20103	nan	Monocots	4679	Allium cepa (related: onion)	Twitching motility	reduced virulence	Gene mutation; gene complementation	27226224
Z1_02722	AE004478_1	62.6	313	1	116	2	314	3	314	9.26e-139	394.0	Q9I697	PHI:9281	gshB	287	PHI:9280_nan	Pseudomonas aeruginosa	PAO1	urinary tract infection	Rodents	10090	Mus musculus (related: house mouse)	Glutathione synthetase	reduced virulence	Gene deletion; gene complementation	31157178
Z1_02729	ADM99914	71.9	402	0	113	10	411	17	418	1.96e-211	586.0	E0SEI0	PHI:8581	lysA (Dda3937_02577)	204038	nan	Dickeya dadantii	3937	soft rot	Eudicots	13427	Cichorium intybus (related: chicory)	Diamiopimelate decarboxylase	reduced virulence	Gene deletion: full	30267562
Z1_02734	AE004724_16	58.3	446	1	185	1	446	1	445	1.84e-178	504.0	Q9HZK6	PHI:8945	nqrA (PA2999)	287	PHI:8940; PHI:8941; PHI:8942; PHI:8943; PHI:8944_PHI:8937; PHI:8938; PHI:8940; PHI:8941; PHI:8942; PHI:8943; PHI:8944_PHI:8939; PHI:8940; PHI:8941; PHI:8942; PHI:8943; PHI:8944	Pseudomonas aeruginosa	PAO1	nosocomial infection	Eudicots_Moths	4236_7137	Galleria mellonella (related: greater wax moth)_Lactuca sativa (related: garden lettuce)	Na(+)-translocating NADH-quinone reductase	unaffected pathogenicity	Gene deletion: full; gene complementation	30804898
Z1_02735	AE004724_15	66.7	412	4	127	1	412	1	402	3.07e-201	559.0	Q9HZK7	PHI:8944	nqrB (PA2998)	287	PHI:8939; PHI:8940; PHI:8941; PHI:8942; PHI:8943; PHI:8945_PHI:8937; PHI:8938; PHI:8940; PHI:8941; PHI:8942; PHI:8943; PHI:8945_PHI:8940; PHI:8941; PHI:8942; PHI:8943; PHI:8945	Pseudomonas aeruginosa	PAO1	nosocomial infection	Eudicots_Moths	4236_7137	Galleria mellonella (related: greater wax moth)_Lactuca sativa (related: garden lettuce)	Na(+)-translocating NADH-quinone reductase	unaffected pathogenicity	Gene deletion: full; gene complementation	30804898
Z1_02736	AE004724_14	47.5	259	3	129	6	258	3	260	1.62e-74	226.0	Q9HZK8	PHI:8943	nqrC (PA2997)	287	PHI:8940; PHI:8941; PHI:8942; PHI:8944; PHI:8945_PHI:8937; PHI:8938; PHI:8940; PHI:8941; PHI:8942; PHI:8944; PHI:8945_PHI:8939; PHI:8940; PHI:8941; PHI:8942; PHI:8944; PHI:8945	Pseudomonas aeruginosa	PAO1	nosocomial infection	Eudicots_Moths	4236_7137	Galleria mellonella (related: greater wax moth)_Lactuca sativa (related: garden lettuce)	Na(+)-translocating NADH-quinone reductase	unaffected pathogenicity	Gene deletion: full; gene complementation	30804898
Z1_02737	AE004724_13	70.5	207	0	61	1	207	2	208	7.34e-100	287.0	Q9HZK9	PHI:8942	nqrD (PA2996)	287	PHI:8937; PHI:8938; PHI:8940; PHI:8941; PHI:8943; PHI:8944; PHI:8945_PHI:8940; PHI:8941; PHI:8943; PHI:8944; PHI:8945_PHI:8939; PHI:8940; PHI:8941; PHI:8943; PHI:8944; PHI:8945	Pseudomonas aeruginosa	PAO1	nosocomial infection	Eudicots_Moths	4236_7137	Galleria mellonella (related: greater wax moth)_Lactuca sativa (related: garden lettuce)	Na(+)-translocating NADH-quinone reductase	unaffected pathogenicity	Gene deletion: full; gene complementation	30804898
Z1_02738	AE004724_12	69.8	202	1	57	1	198	1	202	8.28e-96	275.0	Q9HZL0	PHI:8941	nqrE (PA2995)	287	PHI:8939; PHI:8940; PHI:8942; PHI:8943; PHI:8944; PHI:8945_PHI:8937; PHI:8938; PHI:8940; PHI:8942; PHI:8943; PHI:8944; PHI:8945_PHI:8940; PHI:8942; PHI:8943; PHI:8944; PHI:8945	Pseudomonas aeruginosa	PAO1	nosocomial infection	Eudicots_Moths	4236_7137	Galleria mellonella (related: greater wax moth)_Lactuca sativa (related: garden lettuce)	Na(+)-translocating NADH-quinone reductase	unaffected pathogenicity	Gene deletion: full; gene complementation	30804898
Z1_02739	AE004724_11	68.7	403	2	123	6	408	8	407	9.26e-217	598.0	Q9HZL1	PHI:8940_PHI:11246	nqrF_nqrF (PA2994)	287	PHI:8937; PHI:8938; PHI:8941; PHI:8942; PHI:8943; PHI:8944; PHI:8945_PHI:8941; PHI:8942; PHI:8943; PHI:8944; PHI:8945_PHI:8939; PHI:8941; PHI:8942; PHI:8943; PHI:8944; PHI:8945_nan	Pseudomonas aeruginosa	PAO1	nosocomial infection	Eudicots_Moths_Rodents	4236_7137_10090	Galleria mellonella (related: greater wax moth)_Lactuca sativa (related: garden lettuce)_Mus musculus (related: house mouse)	NADH dehydrogenase_Na(+)-translocating NADH-quinone reductase	unaffected pathogenicity_increased virulence (hypervirulence)	Gene deletion: full; gene complementation	33534802_30804898
Z1_02751	CAD16448	41.9	413	1	239	5	416	13	425	2.29e-113	337.0	Q8XVT6	PHI:123502	proA	305	nan	Ralstonia solanacearum	OE1-1	wilt	Eudicots	4097	Nicotiana tabacum (related: common tobacco)	Gamma-glutamyl phosphate reductase	reduced virulence	Gene deletion: full; gene complementation; gene mutation: characterised	36106083
Z1_02756	ABO12389	72.2	327	0	91	3	329	1	327	2e-169	474.0	A3M645	PHI:10380	RecA	470	nan	Acinetobacter baumannii	ATCC 17978	nosocomial infection	Nematodes_Moths	6239_7137	Galleria mellonella (related: greater wax moth)_Caenorhabditis elegans (related: roundworm)	DNA strand exchange and recombination protein	reduced virulence	Gene deletion: full; gene complementation	32255384
Z1_02758	AAA74502	94.9	59	0	3	1	59	1	59	1.57e-33	107.0	P0DKY7	PHI:4576	RsmA	554	nan	Pectobacterium carotovorum	subsp. carotovorum strain Ecc71	soft rot	Eudicots	4097	Nicotiana tabacum (related: common tobacco)	Carbon storage regulator homolog	increased virulence (hypervirulence)	Gene mutation	8810071
Z1_02765	AE004933_4	40.4	520	10	287	8	516	10	517	2.3000000000000003e-117	355.0	Q9HTY6	PHI:11327_PHI:9280	gshA	287	PHI:9281_nan	Pseudomonas aeruginosa	PAO1	urinary tract infection	Rodents	10090	Mus musculus (related: house mouse)	Glutamate-cysteine ligase_Glutamate--cysteine ligase	reduced virulence	Gene deletion; gene complementation_Gene deletion: full	31157178_32284368
Z1_02766	ABJ02122	84.2	171	0	27	1	171	1	171	5.82e-105	296.0	A1AEN2	PHI:3731	LuxS	562	nan	Escherichia coli	serotype O78:K80:H9 strain χ7122	colibacillosis; cellulitis; swollen head syndrome	Birds	9031	Gallus gallus (related: chicken)	controller in the Quorum sensing	reduced virulence	Gene deletion; gene complementation	23958403
Z1_02780	CBA19780	68.9	103	0	32	1	103	1	103	3.49e-48	148.0	D4HX89	PHI:3675_PHI:3681	yfiA	552	nan	Erwinia amylovora	Ea1189	fire blight	Eudicots	3750_23211	Malus domestica (related: apple)_Pyrus communis (related: pear)	nan	unaffected pathogenicity	Gene mutation; gene complementation	23937726
Z1_02784	ACT14164	78.9	857	0	181	1	857	1	857	0.0	1304.0	C6DC70	PHI:10595	clpB	554	nan	Pectobacterium carotovorum	subsp. carotovorum strain PccS1	soft rot	Eudicots	3711_4097	Nicotiana tabacum (related: common tobacco)_Brassica rapa (related: field mustard)	Chaperone protein	unaffected pathogenicity	Gene deletion: full; gene complementation	32267092
Z1_02791	ACU68761	42.1	76	1	43	176	251	162	236	1.69e-09	55.5	C8CGJ1	PHI:10793	cjrB	562	nan	Escherichia coli	RS218	neonatal meningitis	Rodents_Primates	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Colicin Js sensitivity protein	increased virulence (hypervirulence)	Gene mutation	32762693
Z1_02803	AAB03027	83.5	804	1	132	1	803	213	1016	0.0	1432.0	P32176	PHI:10994	fdoG	562	nan	Escherichia coli	PCN033	infection	Rodents	10090	Mus musculus (related: house mouse)	Formate dehydrogenase-O major subunit	unaffected pathogenicity	Gene deletion: full	32962530
Z1_02831	BAF68836	40.0	45	0	27	11	55	5	49	3.06e-07	47.4	A6QKF4	PHI:12234	icaR	1280	nan	Staphylococcus aureus	MW2	endocarditis; osteomyelitis; pneumonia; septic shock	Moths	7137	Galleria mellonella (related: greater wax moth)	Biofilm operon icaADBC HTH-type negative transcriptional regulator	reduced virulence	Gene mutation	35336176
Z1_02842	CBA24212	79.5	609	1	124	1	608	1	609	0.0	942.0	D4I4L2	PHI:9308	glmS	552	nan	Erwinia amylovora	HKN06P1	fire blight	Eudicots	3750	Malus domestica (related: apple)	Glucosamine-fructose-6-phosphateaminotransferase	reduced virulence	Gene mutation	31152019
Z1_02843	ACC58902	56.5	451	0	196	7	457	4	454	2.17e-177	503.0	B2I2B5	PHI:8042	lpxA	470	nan	Acinetobacter baumannii	ATCC 19606	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	N-acetylglucosamine-1-phosphate uridyltransferase	reduced virulence	Gene mutation; gene complementation	29638177
Z1_02847	ABD31377	55.9	490	2	205	1	490	1	479	2.03e-184	525.0	Q2FWE8	PHI:10773	atpA	1280	nan	Staphylococcus aureus	USA300 LAC 13C	prosthetic joint infection	Rodents_Primates	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	ATP synthase subunit alpha	reduced virulence	Gene deletion: full; gene complementation	32900803
Z1_02851	ACY91043	80.1	272	2	51	4	274	2	271	9.09e-152	423.0	A0A0F6B941	PHI:9436	atpB	28901	PHI:9435	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	gastroenteritis	Rodents	10090	Mus musculus (related: house mouse)	F0F1 ATP synthase subunit A	reduced virulence	Gene mutation	31346161
Z1_02854	ABP91129	49.4	621	2	311	3	622	5	623	4.16e-203	582.0	A4VYE0	PHI:11091	gidA	1307	PHI:11090	Streptococcus suis	SC19	meningitis; septicemia; streptococcal toxic shock syndrome	Rodents	10090	Mus musculus (related: house mouse)	tRNA uridine 5-carboxymethylaminomethyl modification enzyme	reduced virulence	Gene deletion: full; gene complementation	33425782
Z1_02866	AAL21105	64.1	287	1	102	1	287	1	286	5.29e-130	369.0	Q8ZNK8	PHI:11609	yeiE	28901	PHI:11610; PHI:11611_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain HA420	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Putative LysR family transcriptional regulator	reduced virulence	Gene deletion: full; gene complementation	34098734
Z1_02868	CAG61680	47.1	263	2	137	5	266	15	276	3.24e-80	244.0	Q6FM27	PHI:3793	ANP1	5478	nan	Candida glabrata	CBS 138	disseminated candidiasis	Rodents	10090	Mus musculus (related: house mouse)	encode alpha -(1-6)-mannosyl-transferases	increased virulence (hypervirulence)	Gene disruption; gene complementation	23720756
Z1_02869	AE004704_11	42.4	118	4	61	5	120	6	118	2.2e-21	82.0	Q9I074	PHI:10776	PA2769	287	nan	Pseudomonas aeruginosa	PAO1161	infection	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	Nudix hydrolase domain-containing protein	unaffected pathogenicity	Gene deletion: full; gene complementation	32419387
Z1_02875	AAC75236	63.2	174	1	61	7	180	15	185	3.88e-72	215.0	P0AFV4	PHI:11093	MepS	562	nan	Escherichia coli	UTI89	infection	Rodents	10090	Mus musculus (related: house mouse)	Peptidoglycan DD-endopeptidase/peptidoglycan LD-carboxypeptidase	reduced virulence	Gene deletion: full; gene complementation	33391204
Z1_02880	ACT12677	66.7	93	0	31	1	93	1	93	2.4599999999999998e-40	127.0	C6DEJ2	PHI:7469	RplY	554	nan	Pectobacterium carotovorum	subsp. carotovorum strain PccS1	soft rot	Eudicots_Monocots	3711_69721_94108	Zantedeschia aethiopica (related: arum-lily)_Zantedeschia elliottiana (no common name found)_Brassica rapa (related: field mustard)	50S Ribosomal protein	reduced virulence	Gene deletion: full; gene complementation	28853642
Z1_02891	ACY90915	59.3	86	0	35	81	166	74	159	1.36e-23	89.4	D0ZLQ3	PHI:3751	cigR	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	self-limiting gastroenteritis; typhoid-like disease (mice)	Rodents	10090	Mus musculus (related: house mouse)	Anti virulence factor	increased virulence (hypervirulence)	Gene mutation; gene complementation	23950998
Z1_02894	CAA62903	68.9	61	1	18	7	67	4	63	6.14e-25	86.3	P0A355	PHI:7637	CspA	1639	PHI:7638; PHI:7639_PHI:7639_PHI:7638_nan	Listeria monocytogenes	EGD-e	listeriosis	Bony fishes_Primates	7955_9606	Homo sapiens (related: human)_Danio rerio (related: zebrafish)	Cold shock protein	reduced virulence	Gene mutation	29124040
Z1_02917	ACI08342	69.3	361	4	97	1	360	1	348	8.17e-171	478.0	B5XY48	PHI:4160	OmpA2	573	nan	Klebsiella pneumoniae	52.145	pneumonia	Moths	7137	Galleria mellonella (related: greater wax moth)	outer membrane proteins	reduced virulence	Gene mutation	23836821
Z1_02922	CBA20332	80.4	51	0	10	1	51	1	51	3.16e-26	88.6	D4I0C5	PHI:3676_PHI:3682	rmf3	552	nan	Erwinia amylovora	Ea1189	fire blight	Eudicots	3750_23211	Malus domestica (related: apple)_Pyrus communis (related: pear)	nan	unaffected pathogenicity	Gene mutation; gene complementation	23937726
Z1_02937	QVP88165	56.2	381	11	137	2	371	1	362	1.59e-132	382.0	A0A8E6NBK9	PHI:123435	ompD	28901	PHI:123431_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028s	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Porin OmpD	reduced virulence_unaffected pathogenicity	Gene deletion: full	35969640
Z1_02938	ESS34268	43.2	396	4	221	1	392	192	587	1.08e-106	325.0	A0A125YKR6	PHI:11103	AAT	5811	nan	Toxoplasma gondii	RH_PLK	toxoplasmosis	Primates_Rodents	10090_9534	Chlorocebus aethiops (related: grivet)_Mus musculus (related: house mouse)	Aspartate aminotransferase	reduced virulence_unaffected pathogenicity	Gene deletion: full; gene complementation	31907178
Z1_02956	AAL19540	40.6	345	2	198	28	369	26	366	4.86e-76	238.0	Q8ZR36	PHI:9093	fepE	28901	PHI:9092_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain IR715	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Ferric enterobactin (Enterochelin) transporter	reduced virulence	Gene mutation	29447698
Z1_02959	AAA23460	81.2	623	2	114	3	623	1	622	0.0	1009.0	P0A6Z3	PHI:6472	htpG	562	nan	Escherichia coli	SP15	diarrhea	Rodents	10117_10090	Rattus rattus (related: black rat)_Mus musculus (related: house mouse)	heat shock protein 90 chaperone	reduced virulence	Gene mutation	27412582
Z1_02960	AAA23861	69.4	385	0	118	1	385	1	385	4.330000000000001e-195	543.0	P33221	PHI:8653	purT	562	PHI:8652_nan	Escherichia coli	UTI89	infection	Rodents_Primates	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Formate-dependent phosphoribosylglycinamide formyltransferase	reduced virulence_unaffected pathogenicity	Gene deletion: full_Gene deletion: full; gene complementation	30377949
Z1_02967	AE004681_7	40.7	214	3	110	12	223	5	203	5.61e-51	163.0	Q9I0U7	PHI:3783	PA2537	287	nan	Pseudomonas aeruginosa	PAO1	infection	Beetles	7067	Tenebrio molitor (related: yellow mealworm)	acyltransferases	reduced virulence	Altered gene expression / gene regulation: overexpression	23848169
Z1_02970	AEX67621	41.7	60	0	35	7	66	13	72	8.18e-07	48.1	A0A806GD53	PHI:12029	oxyR	1717	nan	Corynebacterium diphtheriae	CDC-E8392	diphtheria	Nematodes_Rodents_Primates	6239_10090_9606	Homo sapiens (related: human)_Caenorhabditis elegans (related: roundworm)_Mus musculus (related: house mouse)	LysR-family transcriptional regulator	unaffected pathogenicity_increased virulence (hypervirulence)	Gene disruption	35169995
Z1_02986	AUU95693	40.7	204	5	113	19	218	20	219	3.72e-50	161.0	A0A086ITU0	PHI:10209	fimC	573	nan	Klebsiella pneumoniae	TOP52	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Molecular chaperone	unaffected pathogenicity	Gene deletion: full	29158434
Z1_02996	ARX33819	100.0	183	0	0	1	183	1	183	4.23e-122	340.0	Q51917	PHI:10243	pmpA	584	PHI:10244_PHI:10245_PHI:10244; PHI:10245_nan	Proteus mirabilis	HI4320	urinary tract infection; urolithiasis	Rodents	10090	Mus musculus (related: house mouse)	F7-2 fimbrial protein	reduced virulence	Gene mutation	30082479
Z1_03003	ACT14364	80.5	329	2	62	1	327	1	329	3.51e-182	504.0	C6DDF7	PHI:10574	rpoS	554	nan	Pectobacterium carotovorum	subsp. carotovorum strain PccS1	soft rot	Monocots	69721	Zantedeschia aethiopica (related: arum-lily)	RNA polymerase sigma factor	unaffected pathogenicity	Gene deletion: full; gene complementation	32267092
Z1_03004	ACN50512	46.0	385	6	145	1	374	1	333	3.4e-97	291.0	Q7CKC8	PHI:9369	nlpD	632	nan	Yersinia pestis	Kim53	bubonic plague	Rodents	10090	Mus musculus (related: house mouse)	Lipoprotein	reduced virulence	Gene mutation; gene complementation	31170147
Z1_03005	AAL21806	63.9	208	0	75	1	208	1	208	7.45e-96	276.0	Q8ZMF9	PHI:6187	pimt	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain E-2375	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Protein isoaspartate methyl transferase	reduced virulence	Gene mutation; gene complementation	27156953
Z1_03008	AAM36589	52.6	154	0	73	1	154	5	158	6.249999999999999e-54	166.0	Q8PLR7	PHI:4145	XAC1722	346	nan	Xanthomonas citri	subsp. citri	canker (citrus)	Eudicots	2711	Citrus sinensis (related: sweet orange)	2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	reduced virulence	Gene mutation	24676796
Z1_03012	ACD60244	48.8	402	3	202	43	444	1	398	9.999999999999999e-129	385.0	B2SI02	PHI:1139	raxQ	347	nan	Xanthomonas oryzae	pv. oryzae strain PXO99A	bacterial blight	Monocots	4530	Oryza sativa (related: rice)	Adenylylsulfate kinase protein required for Ax21 (synonym: AvrXa21) activity	increased virulence (hypervirulence)	Gene disruption; gene complementation	11967067
Z1_03013	ACD60245	68.0	297	0	95	6	302	6	302	3.49e-145	409.0	B2SI03	PHI:1138	raxP (cysD)	347	nan	Xanthomonas oryzae	pv. oryzae strain PXO99A	bacterial blight	Monocots	4530	Oryza sativa (related: rice)	Sulfate adenylyltransferase (ATP) required for Ax21 activity	increased virulence (hypervirulence)	Gene disruption; gene complementation	11967067
Z1_03016	CBA19698	75.4	564	1	138	8	571	9	571	0.0	890.0	D4HWM2	PHI:9323	cysI3	552	nan	Erwinia amylovora	HKN06P1	fire blight	Eudicots	3750_4097	Malus domestica (related: apple)_Nicotiana tabacum (related: common tobacco)	Sulfite reductase	unaffected pathogenicity	Gene mutation	31152019
Z1_03017	ADM99812	59.8	602	2	231	10	604	10	607	8.67e-253	706.0	E0SDK2	PHI:8574	cysJ (Dda3937_00209)	204038	nan	Dickeya dadantii	3937	soft rot	Eudicots	13427	Cichorium intybus (related: chicory)	Sulfite reductase alpha subunit	reduced virulence	Gene deletion: full	30267562
Z1_03021	AAQ65554	53.4	386	2	178	8	392	11	395	4.03e-150	429.0	Q7MX71	PHI:7938	PG0343	837	nan	Porphyromonas gingivalis	W83	periodontitis	Rodents	10090	Mus musculus (related: house mouse)	L-methionine gamma-lyase	reduced virulence	Gene deletion: full	29488863
Z1_03043	EHA48815	57.1	259	0	111	1	259	1	259	4.87e-109	318.0	G4NB53	PHI:5472	MoDeam	318829	nan	Magnaporthe oryzae	KJ201	blast (rice)	Monocots	4530	Oryza sativa (related: rice)	GlcN-6-phosphate deaminase	reduced virulence	Gene deletion: full; gene complementation	26754109
Z1_03054	EAL87202	64.4	365	1	129	4	367	12	376	1.6299999999999998e-172	484.0	Q4WIQ3	PHI:3277	gnoA	746128	PHI:3275	Aspergillus fumigatus	CEA17	invasive pulmonary aspergillosis	Rodents	10090	Mus musculus (related: house mouse)	S-nitrosoglutathione reductase	unaffected pathogenicity	Gene mutation	25309516
Z1_03059	CAL13026	79.4	155	0	32	1	155	1	155	7.76e-89	254.0	A1JQ74	PHI:7671	ybeY	630	nan	Yersinia enterocolitica	serotype O:3 strain 6471/76	yersiniosis	Primates	9606	Homo sapiens (related: human)	Endoribonuclease	reduced virulence	Gene deletion: full; gene complementation	25416689
Z1_03067	AAO57627	58.2	292	2	114	12	295	7	298	2.47e-114	330.0	Q87XK7	PHI:10621	aatJ (PSPTO_4171)	317	nan	Pseudomonas syringae	pv. tomato strain DC3000	bacterial speck (tomato)	Eudicots	3702	Arabidopsis thaliana (related: thale cress)	Substrate-binding protein	reduced virulence	Gene deletion: full; gene complementation	32673374
Z1_03069	AAF41201	42.1	107	0	62	99	205	90	196	7.86e-19	80.1	Q9K034	PHI:8622	ctp (NMB0788)	487	nan	Neisseria meningitidis	NIID84 Δcps	septicemia	Primates	9606	Homo sapiens (related: human)	Cysteine transporter permease	unaffected pathogenicity	Other evidence: ectopic complementation	30538184
Z1_03070	AAF41202	48.8	246	1	119	1	239	1	246	1.88e-73	222.0	Q9K033	PHI:8623	cab (NMB0789)	487	nan	Neisseria meningitidis	NIID84 Δcps	septicemia	Primates	9606	Homo sapiens (related: human)	Cysteine ATP binding protein	unaffected pathogenicity	Other evidence: ectopic complementation	30538184
Z1_03072	BAA35288	52.2	159	1	74	1	157	1	159	9.81e-50	157.0	P0ADC1	PHI:10313	LptE	562	nan	Escherichia coli	KP7600	urinary tract infection	Moths_Rodents	10090_7091	Bombyx mori (related: domestic silkworm)_Mus musculus (related: house mouse)	LPS-assembly protein	unaffected pathogenicity_increased virulence (hypervirulence)	Gene mutation	32324807
Z1_03084	AKA30976	58.8	320	2	129	1	320	1	317	1.85e-134	384.0	V5VBJ6	PHI:6492	lipA	470	nan	Acinetobacter baumannii	ATCC 17978	nosocomial infection	Rodents	10090	Mus musculus (related: house mouse)	Lipase	reduced virulence	Gene deletion: full	26668261
Z1_03087	ACY87244	85.5	69	0	10	1	69	1	69	3.01e-41	127.0	A0A0F6AYC2	PHI:7263	cspE	28901	PHI:7262_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain UMR1	salmonellosis	Rodents_Primates	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Cold shock protein	loss of pathogenicity_reduced virulence_unaffected pathogenicity	Gene deletion: full	28611217
Z1_03093	AIS99989	73.1	398	0	107	1	398	1	398	5.0500000000000004e-210	581.0	A0A086IQC3	PHI:8968	proV	573	nan	Klebsiella pneumoniae	KPPR1	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Glycine betaine/L-proline transport ATP-binding protein	reduced virulence	Gene deletion: full	29712730
Z1_03098	CAA38090	69.2	169	1	48	1	169	1	165	3.46e-76	224.0	P0ACR9	PHI:5407_PHI:7646	MprA_mprA	562	nan	Escherichia coli	UTI89_PA45B	urinary tract infection	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Transcriptional repressor_Transcriptional repressor of an operon encoding the EmrAB efflux pump.	loss of pathogenicity_reduced virulence	Gene mutation; gene complementation	29066548_26671885
Z1_03100	ACO02561	57.6	420	3	168	4	413	72	491	6.48e-149	430.0	C0RLS8	PHI:11544	B0754	29459	nan	Brucella melitensis	M28	brucellosis	Rodents	10090	Mus musculus (related: house mouse)	ABC transporter substrate-binding protein	unaffected pathogenicity	Gene deletion: full; gene complementation	32778612
Z1_03107	AE013695_1	69.7	880	0	267	1	880	1	880	0.0	1215.0	Q8D179	PHI:8899	yfiQ (Yp_0659)	632	nan	Yersinia pestis	201	plague	Rodents	10090	Mus musculus (related: house mouse)	Protein acetyltransferase	reduced virulence	Gene deletion: full; gene complementation	29610260
Z1_03121	AAL23157	84.6	188	0	29	1	188	1	188	8.05e-118	330.0	P64036	PHI:6420	EF-P	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Elongation factor	increased virulence (hypervirulence)	Altered gene expression / gene regulation: downregulation	27350030
Z1_03123	ACY89860	55.4	184	2	78	1	184	1	180	8.93e-69	207.0	A0A0F6B5R6	PHI:10073	STM14_RS15300	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Formate hydrogenlyase regulator	unaffected pathogenicity	Gene deletion: full	32038592
Z1_03125	ACY89858	57.0	298	1	127	15	311	5	302	1.0100000000000001e-103	304.0	A0A0F6B5R4	PHI:10071	STM14_RS15290	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Formate hydrogenlyase subunit 3	unaffected pathogenicity	Gene deletion: full	32038592
Z1_03129	ACY89857	75.8	565	1	136	14	577	5	569	0.0	894.0	A0A0F6B5R3	PHI:10070	STM14_RS15285	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Formate hydrogenlyase subunit 4	unaffected pathogenicity	Gene deletion: full	32038592
Z1_03130	ACY89856	52.1	167	2	78	1	167	1	165	3.46e-45	145.0	A0A0F6B5R2	PHI:10069	STM14_RS15280	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Formate hydrogenlyase subunit 5	unaffected pathogenicity	Gene deletion: full	32038592
Z1_03131	ACY89855	63.9	244	2	83	15	258	16	254	5.43e-113	323.0	A0A0F6B5R1	PHI:10068	STM14_RS15275	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Formate hydrogenlyase complex iron-sulfur subunit	unaffected pathogenicity	Gene deletion: full	32038592
Z1_03132	ACY89854	49.2	130	1	65	6	134	4	133	3.78e-40	129.0	A0A0F6B5R0	PHI:10067	STM14_RS15270	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	NADH-quinone oxidoreductase subunit	unaffected pathogenicity	Gene deletion: full	32038592
Z1_03133	ACY89853	64.8	142	0	50	10	151	4	145	2.41e-67	200.0	A0A0F6B5Q9	PHI:10066	STM14_RS15265	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Formate hydrogenlyase maturation protein	unaffected pathogenicity	Gene deletion: full	32038592
Z1_03135	CAR44976	99.6	527	0	2	1	527	1	527	0.0	1078.0	B4EXB5	PHI:123442	yntA	584	PHI:123443_PHI:123444_nan	Proteus mirabilis	HI4320	catheter-associated urinary tract infection	Rodents	10090	Mus musculus (related: house mouse)	Putative nickel/di-oligopepetide ABC transporter, substrate-binding protein	reduced virulence_unaffected pathogenicity	Gene deletion: full	32255226
Z1_03144	CAJ11366	42.6	230	4	127	88	315	63	289	4.01e-44	151.0	Q2YS30	PHI:11161	SerB (BAB1_1410)	29459	nan	Brucella melitensis	2308	brucellosis	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Phosphoserine phosphatase SerB:Haloacid dehalogenase-like hydrolase:HAD-superfamily hydrolase, subfamily IB	reduced virulence	Gene deletion: full; gene complementation	31740531
Z1_03188	BAA14390	71.3	223	0	64	1	223	1	223	5.7000000000000006e-117	331.0	P23836	PHI:10955	phoP	562	nan	Escherichia coli	serotype O157:H7	infection	Rodents	10090	Mus musculus (related: house mouse)	Transcriptional regulatory protein	reduced virulence	Gene deletion: full; gene complementation	33173003
Z1_03189	ACY87894	54.4	480	2	217	8	487	10	487	6.68e-180	511.0	D0ZV89	PHI:6318_PHI:7356_PHI:4899	PhoQ	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	pH sensing_Histidine kinase with a periplasmic sensor domain (PD) that promotes virulence by detecting the macrophage phagosome	reduced virulence_unaffected pathogenicity	Gene mutation	27282333_26002083_28851823
Z1_03193	CAL20275	71.7	269	2	74	4	272	1	267	1.9e-139	392.0	Q8ZFR1	PHI:8898	cobB (Yp_1760)	632	nan	Yersinia pestis	201	plague	Rodents	10090	Mus musculus (related: house mouse)	Protein deacetylase	reduced virulence	Gene deletion: full; gene complementation	29610260
Z1_03195	BAB43798	43.6	204	0	115	24	227	20	223	8.039999999999999e-52	167.0	A0A0H3JS81	PHI:6579	VraD	1280	PHI:6580; PHI:6581	Staphylococcus aureus	JE2	skin infection; food poisoning; respiratory disease	Moths	7137	Galleria mellonella (related: greater wax moth)	Involved in Gallidermin and Daptomycin Resistance	reduced virulence	Gene mutation; gene complementation	26856834
Z1_03199	CEI15921	57.6	436	4	176	5	435	4	435	7.239999999999999e-168	477.0	A0A069PYL4	PHI:11248	ndh	287	nan	Pseudomonas aeruginosa	PAO1	nosocomial infection	Rodents	10090	Mus musculus (related: house mouse)	NADH dehydrogenase	increased virulence (hypervirulence)	Gene deletion: full; gene complementation	33534802
Z1_03201	AAG06393	50.2	325	5	154	2	324	3	321	3.34e-93	279.0	Q9HZK0	PHI:123476	nagZ	287	nan_PHI:123478_PHI:123480_PHI:123479_PHI:123477	Pseudomonas aeruginosa	PAO1	nosocomial infection	Moths	7137	Galleria mellonella (related: greater wax moth)	permease	reduced virulence	Gene deletion: full_Gene deletion: full; other evidence: cloning	35171032
Z1_03211	FGSG_07226	45.9	427	7	211	4	412	2	426	9.55e-120	353.0	I1RSU2	PHI:724_PHI:730	KSA1_PKS9	5518	nan	Fusarium graminearum	PH-1	fusarium ear blight	Monocots	4564	Triticum (related: wheat)	Polyketide synthase	unaffected pathogenicity	Gene disruption	16278459
Z1_03212	AE004613_3	50.0	76	0	38	1	76	1	76	7.27e-19	71.6	O52658	PHI:8556	Acp1 (PA1869)	287	PHI:8557_nan	Pseudomonas aeruginosa	PAO1	nosocomial infection	Rodents	10090	Mus musculus (related: house mouse)	Acyl carrier protein	increased virulence (hypervirulence)	Gene deletion: full; gene complementation	30294316
Z1_03213	CAD14754	63.1	244	1	87	3	243	5	248	3.0800000000000003e-97	283.0	Q8Y0J2	PHI:5271	fabG1	305	nan	Ralstonia solanacearum	GMI1000	bacterial wilt	Eudicots	4081	Solanum lycopersicum (related: tomato)	3-ketoacyl-acyl carrier protein reductase	lethal	Gene disruption; gene complementation	26490537
Z1_03222	ADX16885	56.0	1178	19	390	1	1166	1	1062	0.0	953.0	E8XEV4	PHI:3723	RNase E	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain SL1344	food poisoning	Moths	7137	Galleria mellonella (related: greater wax moth)	endoribonucleases	reduced virulence	Gene mutation; gene complementation	23913419
Z1_03228	ACT13704	41.0	83	0	49	1	83	1	83	7.58e-16	70.1	C6D9H7	PHI:10584	PccS1_004012	554	nan	Pectobacterium carotovorum	subsp. carotovorum strain PccS1	soft rot	Monocots	69721	Zantedeschia aethiopica (related: arum-lily)	LysR family transcriptional regulator, partial	unaffected pathogenicity	Gene deletion: full; gene complementation	32267092
Z1_03232	ADN00484	58.5	272	2	111	1	271	5	275	2.26e-104	303.0	E0SLG2	PHI:8567	hdfR (Dda3937_04419)	204038	nan	Dickeya dadantii	3937	soft rot	Eudicots	13427	Cichorium intybus (related: chicory)	DNA-binding transcriptional regulator	reduced virulence	Gene deletion: full	30267562
Z1_03234	CDO16329	59.2	512	2	198	1	508	1	505	3.4800000000000003e-210	590.0	W9BJ64	PHI:7572	yfiB	573	nan	Klebsiella pneumoniae	LM21	pneumonia	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	Outer membrane lipoprotein which acts as a sensor of YfiBNR system	unaffected pathogenicity	Gene deletion: full; gene complementation	25261190
Z1_03236	EHA56980	43.3	577	11	280	2	538	83	652	4.15e-147	437.0	G4MMK2	PHI:3975	MoIlv2	318829	nan	Magnaporthe oryzae	Guy11	blast (rice)	Monocots	4530_4513	Oryza sativa (related: rice)_Hordeum vulgare (related: barley)	Acetolactate synthases	loss of pathogenicity	Gene disruption; gene complementation	23782532
Z1_03240	CBA19104	79.0	515	1	106	1	515	1	513	1.07e-297	813.0	D4HUI1	PHI:9318	ilvA	552	nan	Erwinia amylovora	HKN06P1	fire blight	Eudicots	3750	Malus domestica (related: apple)	Threonine dehydratase	reduced virulence	Gene mutation	31152019
Z1_03248	BAA00903	82.4	108	0	19	1	108	1	108	1.18e-65	192.0	P0AA28	PHI:2644	thioredoxin 1	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028	food poisoning	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	Redox activity	reduced virulence	Chemical complementation_Gene deletion: full; gene complementation	23028994
Z1_03249	AGU62228	52.0	415	5	190	7	419	24	431	3.06e-147	424.0	T1YC56	PHI:8558	Rho	1280	nan	Staphylococcus aureus	HG001	nosocomial infection	Rodents	10090	Mus musculus (related: house mouse)	Transcriptional regulator	increased virulence (hypervirulence)	Gene mutation; gene complementation	30228237
Z1_03250	CDG14825	77.9	353	0	78	1	353	21	373	3.1300000000000004e-200	553.0	V6A547	PHI:4074	wecA	615	nan	Serratia marcescens	2170	hemolymph bleeding	Moths	7091	Bombyx mori (related: domestic silkworm)	virulence factor	reduced virulence	Gene disruption	24530643
Z1_03252	AE014976_8	51.9	370	2	169	1	369	4	365	1.73e-125	365.0	Q8DTB7	PHI:7052	epsC	1309	nan	Streptococcus mutans	UA159	infective endocarditis	Primates_Rodents	10117_9606	Homo sapiens (related: human)_Rattus rattus (related: black rat)	Exopolysaccharide synthesis enzyme [UDP-N-acetylglucosamine 2-epimerase]	reduced virulence	Gene mutation; gene complementation	27572331
Z1_03255	AE004929_3	66.3	285	0	96	2	286	4	288	2.5299999999999998e-138	390.0	Q9HU22	PHI:7634	rmlA	287	nan	Pseudomonas aeruginosa	PAO1	infection	Eudicots_Rodents	4236_10090	Lactuca sativa (related: garden lettuce)_Mus musculus (related: house mouse)	Glucose-1-phosphate thymidylyltransferase	loss of pathogenicity_reduced virulence	Gene deletion: full	29045498
Z1_03271	AAF93300	53.2	838	10	379	1	832	1	831	7.67e-314	881.0	Q9KVL9	PHI:9840	cya	666	nan	Vibrio cholerae	SIO	infection	Flies	7227	Drosophila melanogaster (related: fruit fly)	Adenylate cyclase	reduced virulence	Gene deletion: full	30224439
Z1_03281	AAO90037	41.0	210	6	113	85	291	143	344	2.01e-41	144.0	Q83E43	PHI:7998	pldA (CBU_0489)	777	nan	Coxiella burnetii	Nine Mile phase II clone 4	q fever	Primates	9606	Homo sapiens (related: human)	Outer membrane phospholipase A	reduced virulence	Gene deletion: full; gene complementation	29661138
Z1_03296	AAL22819	71.7	258	0	73	1	258	1	258	6.95e-129	364.0	Q7CPD5	PHI:8726	tatC	28901	PHI:8727_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain SL1344	typhoid	Rodents	10090	Mus musculus (related: house mouse)	Sec-independent protein translocase	reduced virulence	Gene mutation	30379938
Z1_03297	CNR43407	77.8	99	1	21	1	99	1	98	2.91e-42	138.0	A0A0U1FMH1	PHI:8758	tatB	28901	PHI:8757; PHI:8759	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	salmonellosis	Eukaryotes	44689	Dictyostelium discoideum (related: amoeba)	Sec-independent protein translocase protein	reduced virulence	Gene deletion: full; gene complementation	30574134
Z1_03298	CNR43436	61.4	88	1	30	1	88	1	84	3.03e-26	90.9	A0A0U1FZZ2	PHI:8757	tatA	28901	PHI:8758; PHI:8759	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	salmonellosis	Eukaryotes	44689	Dictyostelium discoideum (related: amoeba)	Sec-independent protein translocase protein	reduced virulence	Gene deletion: full; gene complementation	30574134
Z1_03301	AHM70914	42.0	226	1	128	25	250	11	233	1.09e-59	187.0	W8TW76	PHI:10294	ubiE	1280	nan	Staphylococcus aureus	ATCC 29213	skin infection; food poisoning; respiratory disease	Primates	9606	Homo sapiens (related: human)	Ubiquinone biosynthesis methyltransferase	unaffected pathogenicity	Gene disruption; gene complementation	30642903
Z1_03308	CBA19150	75.4	755	2	182	1	754	1	752	0.0	1174.0	D4HUM7	PHI:9315	metE	552	nan	Erwinia amylovora	HKN06P1	fire blight	Eudicots	3750_4097	Malus domestica (related: apple)_Nicotiana tabacum (related: common tobacco)	5-Methyltetrahydropteroyltriglutamate-homocysteine methyltransferase	reduced virulence	Gene mutation	31152019
Z1_03309	CBA19149	71.7	297	0	84	1	297	1	297	8.55e-157	439.0	D4HUM6	PHI:9326	metR	552	nan	Erwinia amylovora	HKN06P1	fire blight	Eudicots	3750	Malus domestica (related: apple)	HTH-type transcriptional regulator	unaffected pathogenicity	Gene mutation	31152019
Z1_03322	AAA24098	44.2	52	0	29	20	71	460	511	3.3e-06	47.8	P19642	PHI:4631	pafP	562	PHI:4630_nan	Escherichia coli	CFT073	urinary tract infection	Rodents	10090	Mus musculus (related: house mouse)	Transcription Regulator	reduced virulence	Gene deletion: full; gene complementation	25069986
Z1_03341	AEU09842	46.7	199	0	106	30	228	34	232	6.58e-70	212.0	A6GV51	PHI:11406	dsbC	573	nan	Klebsiella pneumoniae	ATCC 43816; MKP203	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Thiol:disulfide interchange protein	reduced virulence	Gene deletion: full; gene complementation	31988174
Z1_03366	AHF65896	40.0	255	1	152	4	257	29	283	4.9799999999999995e-54	175.0	W0H866	PHI:3165	hopA1	36746	nan	Pseudomonas cichorii	JBC1	leaf spot (celery); leaf spot (eggplant); leaf spot (sweet pepper); wilt rot (muskmelon); stem rot (muskmelon); stem rot (chrysanthemum); leaf spot (soybean)	Eudicots	4081_3656_4073_4111_3659_3712_3847	Cucumis melo (related: muskmelon)_Glycine max (related: soybean)_Cucumis sativus (related: cucumber)_Capsicum frutescens (related: hot pepper)_Solanum melongena (related: eggplant)_Brassica oleracea (no common name found)_Solanum lycopersicum (related: tomato)	Effector (plant avirulence determinant)	unaffected pathogenicity_effector (plant avirulence determinant)	Gene deletion: full; gene complementation	25127676
Z1_03372	CEF86247	40.1	459	5	269	5	461	637	1091	4.37e-94	314.0	I1S2C4	PHI:5068	MCC	5518	nan	Fusarium graminearum	Z-3639	fusarium head blight	Monocots	4565	Triticum aestivum (related: bread wheat)	Encoding methylcrotonyl-CoA-carboxylase	reduced virulence	Gene mutation; gene complementation	26248604
Z1_03379	ACY88597	77.3	463	1	104	1	463	1	462	2.09e-267	731.0	A0A0F6B259	PHI:123379	narK	28901	PHI:123380_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028s	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Nitrate/nitrite transporter	reduced virulence	Gene deletion: full	35806223
Z1_03380	CAA34303	79.4	1240	2	253	1	1240	1	1238	0.0	2129.0	P09152	PHI:10512	narG	562	PHI:10513; PHI:10514; PHI:10515; PHI:10516; PHI:10517; PHI:10518; PHI:10519; PHI:10520; PHI:10521; PHI:10522; PHI:10523; PHI:10524; PHI:10525; PHI:10526	Escherichia coli	CFT073	urinary tract infection	Rodents	10117	Rattus rattus (related: black rat)	Respiratory nitrate reductase 1 alpha chain	reduced virulence	Gene deletion: full; gene complementation	32082279
Z1_03381	CAA34304	84.6	508	1	76	1	506	1	508	0.0	906.0	P11349	PHI:10513	narH	562	PHI:10512; PHI:10514; PHI:10515; PHI:10516; PHI:10517; PHI:10518; PHI:10519; PHI:10520; PHI:10521; PHI:10522; PHI:10523; PHI:10524; PHI:10525; PHI:10526	Escherichia coli	CFT073	urinary tract infection	Rodents	10117	Rattus rattus (related: black rat)	Respiratory nitrate reductase 1 beta chain	reduced virulence	Gene deletion: full; gene complementation	32082279
Z1_03382	AAC74310	58.0	231	1	96	2	232	1	230	6.800000000000001e-88	258.0	P0AF26	PHI:10514	narJ	562	PHI:10512; PHI:10513; PHI:10515; PHI:10516; PHI:10517; PHI:10518; PHI:10519; PHI:10520; PHI:10521; PHI:10522; PHI:10523; PHI:10524; PHI:10525; PHI:10526	Escherichia coli	CFT073	urinary tract infection	Rodents	10117	Rattus rattus (related: black rat)	Nitrate reductase molybdenum cofactor assembly chaperone	reduced virulence	Gene deletion: full; gene complementation	32082279
Z1_03383	AAC74311	77.3	225	0	51	1	225	1	225	2.94e-129	362.0	P11350	PHI:10515	narI	562	PHI:10512; PHI:10513; PHI:10514; PHI:10516; PHI:10517; PHI:10518; PHI:10519; PHI:10520; PHI:10521; PHI:10522; PHI:10523; PHI:10524; PHI:10525; PHI:10526	Escherichia coli	CFT073	urinary tract infection	Rodents	10117	Rattus rattus (related: black rat)	Respiratory nitrate reductase 1 gamma chain	reduced virulence	Gene deletion: full; gene complementation	32082279
Z1_03389	AAW75843	43.7	350	6	155	218	531	142	485	1.79e-76	248.0	Q5GZM8	PHI:3219	fleQ	347	nan	Xanthomonas oryzae	pv. oryzae strain PXO99A	bacterial leaf blight	Monocots	4530	Oryza sativa (related: rice)	Flagellar motility	unaffected pathogenicity	Gene deletion: full; gene complementation	25126992
Z1_03390	ACY89850	62.2	185	1	66	1	185	1	181	1.82e-84	245.0	A0A0F6B5Q6	PHI:10064	STM14_RS15255	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Hypothetical protein	unaffected pathogenicity	Gene deletion: full	32038592
Z1_03391	ACY89864	53.5	114	1	52	1	113	1	114	6.469999999999998e-41	130.0	A0A0F6B5S0	PHI:10075	STM14_RS15310	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Hydrogenase nickel incorporation protein	unaffected pathogenicity	Gene deletion: full	32038592
Z1_03392	ACY89866	53.8	93	3	36	1	90	1	89	3.61e-28	96.3	A0A0F6B5S2	PHI:10077	STM14_RS15320	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Hydrogenase formation protein	unaffected pathogenicity	Gene deletion: full	32038592
Z1_03397	ACR67633	87.5	599	1	74	1	598	1	599	0.0	1070.0	C5BDL7	PHI:2960	frdA	67780	nan	Edwardsiella ictaluri	93-146	enteric septicemia	Bony fishes	7998	Ictalurus punctatus (related: channel catfish)	Fumarate reductase	reduced virulence	Gene deletion: partial	23762452
Z1_03411	AAC77037	80.3	532	1	104	20	551	19	549	4.35e-294	806.0	P32705	PHI:9229	actP	562	PHI:9227; PHI:9228_nan	Escherichia coli	FY26	avian colisepticemia	Birds_Rodents	9031_10090_8839	Gallus gallus (related: chicken)_Anas platyrhynchos (related: mallard)_Mus musculus (related: house mouse)	Acetate/glycolate:cation symporter	reduced virulence_unaffected pathogenicity	Gene mutation; gene complementation	31046828
Z1_03412	AAC77038	61.8	102	0	39	1	102	1	102	1.36e-39	125.0	P0AF54	PHI:9228	yjcH	562	PHI:9227; PHI:9229	Escherichia coli	FY26	avian colisepticemia	Birds_Rodents	9031_10090_8839	Gallus gallus (related: chicken)_Anas platyrhynchos (related: mallard)_Mus musculus (related: house mouse)	Conserved inner membrane protein	reduced virulence_unaffected pathogenicity	Gene mutation; gene complementation	31046828
Z1_03413	AAC43163	78.6	650	0	139	1	650	1	650	0.0	1082.0	P27550	PHI:9227	acs	562	nan_PHI:9228; PHI:9229	Escherichia coli	FY26	avian colisepticemia	Birds_Rodents	9031_10090_8839	Gallus gallus (related: chicken)_Anas platyrhynchos (related: mallard)_Mus musculus (related: house mouse)	Acetyl-coenzyme A synthetase	reduced virulence_unaffected pathogenicity	Gene mutation; gene complementation	31046828
Z1_03414	AAC43331	77.2	206	1	46	1	206	1	205	2.91e-120	338.0	P43019	PHI:11376	sodA	28901	PHI:11377_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028	salmonellosis	Moths	7137	Galleria mellonella (related: greater wax moth)	Cytoplasmic superoxide dismutase	reduced virulence	Gene deletion: full	33732665
Z1_03420	CAA33253	50.0	100	1	47	217	313	329	428	4.23e-25	102.0	P11557	PHI:6729	damX	562	nan	Escherichia coli	UTI89	urinary tract infection	Rodents	10090	Mus musculus (related: house mouse)	Cell division protein	reduced virulence	Gene mutation	27486187
Z1_03421	ACR27505	55.2	344	2	152	1	344	1	342	3.93e-123	357.0	C5A9K4	PHI:4250	aroB	337	nan	Burkholderia glumae	411gr-6	panicle blight	Monocots	4530	Oryza sativa (related: rice)	3-dehydroquinate synthase	reduced virulence	Gene mutation	24754446
Z1_03429	AE004930_7	42.8	180	2	100	5	181	3	182	8.68e-48	152.0	Q9HU13	PHI:10783	PA5176	287	nan	Pseudomonas aeruginosa	PAO1161	infection	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	Nudix hydrolase domain-containing protein	reduced virulence	Gene deletion: full; gene complementation	32419387
Z1_03433	EAL19243	47.4	504	9	247	44	537	53	548	3.04e-145	427.0	F5HAA8	PHI:424	PCK1	5207	nan	Cryptococcus neoformans	H99	cryptococcosis	Rodents	10090	Mus musculus (related: house mouse)	Phosphoenolpyruvate carboxykinase	reduced virulence	Gene deletion; gene complementation	15765146
Z1_03465	ALD83591	83.5	164	0	27	1	164	1	164	2.71e-102	289.0	A0A0F7DI09	PHI:11418	ppiB	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Peptidyl-prolyl cis-trans isomerase	reduced virulence	Gene deletion: full	31111418
Z1_03467	AAC49755	47.9	163	1	83	11	173	396	556	1.13e-40	142.0	Q92210	PHI:196	ADE2	5476	nan	Candida albicans	CAI-7	candidiasis	Rodents	10090	Mus musculus (related: house mouse)	Phosphoribosylaminoimidazole carboxylase	reduced virulence	Gene disruption; gene complementation	11254618
Z1_03479	CAV17749	46.6	915	8	457	75	982	62	951	7.57e-258	747.0	B7VKI8	PHI:5275	copA	212663	nan	Vibrio tasmaniensis	LGP32	nan	Bivalves	29159	Crassostrea gigas (related: pacific oyster)	Copper homeostasis	reduced virulence	Gene deletion: full; gene complementation	26472275
Z1_03507	AAL21747	43.6	94	0	53	157	250	193	286	1.02e-14	70.9	P0CL09	PHI:631	hilC	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain SL1344	gastroenteritis	Rodents	10090	Mus musculus (related: house mouse)	nan	reduced virulence	Other evidence	16113260
Z1_03514	CCP43395	44.1	127	2	63	3	121	4	130	2.18e-18	73.6	P9WHE3	PHI:7583	Rv0652 (rplL)	1773	nan	Mycobacterium tuberculosis	CDC1551	tuberculosis	Primates	9606	Homo sapiens (related: human)	50S ribosomal protein	increased virulence (hypervirulence)	Altered gene expression / gene regulation: overexpression	26605666
Z1_03515	ABO10757	70.7	1363	9	368	1	1338	1	1357	0.0	1871.0	A3M1G3	PHI:7860	RpoB	470	nan	Acinetobacter baumannii	ATCC 17978	nosocomial infection	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	beta-subunit of the RNA polymerase	reduced virulence	Gene mutation; gene complementation	28507065
Z1_03519	AAO53978	47.2	252	4	126	4	252	12	259	1.96e-62	195.0	Q88AF6	PHI:123321	thiG (pspto_0434)	317	PHI:123318; PHI:123319; PHI:123320_PHI:123320	Pseudomonas syringae	pv. tomato strain DC3000	bacterial speck	Eudicots	4081	Solanum lycopersicum (related: tomato)	Thiazole synthase	reduced virulence	Gene deletion: full; gene complementation	35783427
Z1_03529	ACY83030	74.4	90	0	23	1	90	1	90	7.9e-42	130.0	D0Z9U0	PHI:3074	hupA	636	nan	Edwardsiella tarda	EIB202	hemorrhagic septicemia	Bony fishes	7955	Danio rerio (related: zebrafish)	Nucleoid-associated protein, is a basic DNA-binding protein involved in gene regulation	reduced virulence	Gene mutation: characterised; gene complementation	24793099
Z1_03531	AAY47590	65.7	426	1	145	1	426	1	425	1.8200000000000002e-192	539.0	Q4UZD3	PHI:3942	XC_0509	339	nan	Xanthomonas campestris	pv. campestris strain 8004	black rot	Eudicots	3726	Raphanus sativus (related: radish)	Phosphoribosylamine-glycine ligase	reduced virulence	Gene mutation	23819805
Z1_03534	AAK88486	50.3	149	0	74	1	149	9	157	3.1000000000000003e-44	142.0	Q7CWA3	PHI:10827	bfr (atu2771)	358	nan	Agrobacterium tumefaciens	C58	crown gall	Eudicots	4113_23013	Solanum tuberosum (related: potato)_Kalanchoe daigremontiana (related: devil's backbone)	Bacterioferritin	reduced virulence	Gene deletion: full; gene complementation	32678502
Z1_03539	FGSG_01290	48.5	301	9	114	7	268	59	357	2.22e-74	230.0	I1RCH5	PHI:1569	GzOB009	5518	nan	Fusarium graminearum	GZ3639	fusarium ear blight	Monocots	4564	Triticum (related: wheat)	transcription factor	lethal	Gene deletion	22028654
Z1_03546	CAE43883	74.0	123	1	31	1	123	1	122	4.11e-59	176.0	Q7VTC1	PHI:11120	rplN	520	nan	Bordetella pertussis	Tohama I	pertussis	Rodents_Primates	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	50S ribosomal protein	unaffected pathogenicity_increased virulence (hypervirulence)	Gene mutation	33293402
Z1_03556	CAD00690	42.9	427	7	230	16	434	11	431	7.62e-108	324.0	Q8Y448	PHI:5257	secY	1639	PHI:5356_PHI:5355	Listeria monocytogenes	10403S	listeriosis	Rodents	10090	Mus musculus (related: house mouse)	Protein translocase subunit SecY	increased virulence (hypervirulence)	Gene mutation	25535272
Z1_03567	CAG76898	68.5	428	1	128	1	421	1	428	1.76e-216	599.0	Q6D000	PHI:2694	rsmB	29471	PHI:2695_nan	Pectobacterium atrosepticum	SCRI 1043	tuber rot; blackleg disease	Eudicots	4113	Solanum tuberosum (related: potato)	Modulates plant cell wall-degrading enzymes	loss of pathogenicity_reduced virulence	Gene deletion: full; gene complementation	23113713
Z1_03570	AAK99947	41.2	204	1	119	76	279	75	277	7.070000000000001e-47	160.0	Q8DPI7	PHI:11059	dprA	1313	PHI:11060_nan	Streptococcus pneumoniae	serotype 2 strain D39	pneumococcal pneumonia	Rodents	10090	Mus musculus (related: house mouse)	DNA processing protein	reduced virulence_increased virulence (hypervirulence)	Gene deletion: full	31451619
Z1_03636	AAM37897	43.6	55	0	31	12	66	21	75	4.14e-07	47.4	Q8PI46	PHI:9118	TfmR (XAC3052)	346	PHI:9119_nan	Xanthomonas citri	subsp. citri strain 306	canker (citrus)	Eudicots	2711	Citrus sinensis (related: sweet orange)	TetR-family transcriptional regulator, T3SS and fatty acid mechanism regulator	reduced virulence	Gene deletion: full; gene complementation_Gene mutation	30919570
Z1_03714	AHM69299	75.3	295	0	73	1	295	99	393	2.53e-165	463.0	W8TRT9	PHI:10282	tufA	1280	PHI:10278_nan	Staphylococcus aureus	ATCC 29213	skin infection; food poisoning; respiratory disease	Primates	9606	Homo sapiens (related: human)	Elongation factor Tu	unaffected pathogenicity_increased virulence (hypervirulence)	Gene mutation: characterised; gene complementation	30642903