qseqid	Gene ID	Identity	length	gapopen	mismatch	qstart	qend	sstart	send	E_value	bitscore	Protein ID	PHI_MolConn_ID	Gene	Pathogen ID	Multiple mutation	Pathogen species	Pathogen strain	Disease	Host description	Host ID	Host species	Gene Function	Mutant Phenotype	Exp. Technique-stable	PMID
C1_00013	AHF65896	49.7	185	0	93	42	226	99	283	8.02e-58	183.0	W0H866	PHI:3165	hopA1	36746	nan	Pseudomonas cichorii	JBC1	leaf spot (celery); leaf spot (eggplant); leaf spot (sweet pepper); wilt rot (muskmelon); stem rot (muskmelon); stem rot (chrysanthemum); leaf spot (soybean)	Eudicots	4081_3656_4073_4111_3659_3712_3847	Cucumis melo (related: muskmelon)_Glycine max (related: soybean)_Cucumis sativus (related: cucumber)_Capsicum frutescens (related: hot pepper)_Solanum melongena (related: eggplant)_Brassica oleracea (no common name found)_Solanum lycopersicum (related: tomato)	Effector (plant avirulence determinant)	unaffected pathogenicity_effector (plant avirulence determinant)	Gene deletion: full; gene complementation	25127676
C1_00018	ACL33700	48.6	249	3	124	2	249	3	248	2.31e-76	230.0	B8F8P8	PHI:6900	vacJ	738	nan	Glaesserella parasuis	HS49	glasser's disease	Rodents	10090	Mus musculus (related: house mouse)	virulence related outer membrane lipoprotein	reduced virulence	Gene deletion: full; gene complementation	27988234
C1_00031	KU295573	46.3	255	6	125	7	255	25	273	2.36e-75	228.0	P76498	PHI:6598	YfcO	562	nan	Escherichia coli	DE205B	neonatal meningitis	Birds	8839	Anas platyrhynchos (related: mallard)	nan	reduced virulence	Gene deletion: full; gene complementation	27616446
C1_00033	AAY48631	49.8	295	3	142	9	300	5	296	1.5500000000000002e-88	265.0	Q4UWE2	PHI:3966	XC_1565	339	nan	Xanthomonas campestris	pv. campestris strain 8004	black rot	Eudicots	3726	Raphanus sativus (related: radish)	N-5-glutamine S-adenosyl-L-methionine-dependent methyltransferase	reduced virulence	Gene mutation	23819805
C1_00034	EAL88405	44.5	384	5	178	4	352	2	385	3.63e-96	290.0	Q4WJ77	PHI:7654	aroB	746128	nan	Aspergillus fumigatus	AfS35	invasive pulmonary aspergillosis	Rodents	10090	Mus musculus (related: house mouse)	Chorismate synthase	reduced virulence	Gene deletion: full; gene complementation	26605426
C1_00046	ACR27839	51.5	196	2	90	1	193	1	194	3.36e-66	202.0	C5ABM8	PHI:123500	dbcA(bglu_1g06460)	337	nan	Burkholderia glumae	BGR1	bacterial panicle blight (rice)	Monocots	4530	Oryza sativa (related: rice)	membrane transporter	reduced virulence	Gene deletion: full; gene complementation	34260305
C1_00047	AAW36851	47.3	264	1	136	11	274	17	277	1.98e-79	241.0	Q5HF73	PHI:10348	accD	1280	nan	Staphylococcus aureus	AH1263	skin infection; food poisoning; respiratory disease	Rodents	10090	Mus musculus (related: house mouse)	Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta	reduced virulence	Gene deletion: full	32430471
C1_00051	CBA21663	88.9	505	0	56	1	505	1	505	0.0	899.0	D4HXG4	PHI:9317	purF	552	nan	Erwinia amylovora	HKN06P1	fire blight	Eudicots	3750	Malus domestica (related: apple)	Amidophosphoribosyltransferase	reduced virulence	Gene mutation	31152019
C1_00054	CAJ12778	40.0	240	4	126	26	258	25	253	9.69e-55	175.0	Q2YKP4	PHI:7201	bab2_0612	235	nan	Brucella abortus	2308	ovine brucellosis	Rodents	10090	Mus musculus (related: house mouse)	putative glutamate-binding protein	reduced virulence	Gene deletion: full	28588127
C1_00064	AE004897_4	40.1	167	1	98	1	165	1	167	5.6e-35	119.0	Q9HUW9	PHI:10782	PA4841	287	nan	Pseudomonas aeruginosa	PAO1161	infection	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	Nudix hydrolase domain-containing protein	unaffected pathogenicity	Gene deletion: full; gene complementation	32419387
C1_00066	QPQ68955	96.5	714	1	24	1	714	1	713	0.0	1315.0	A0A8E6NAW3	PHI:123168	pta	28901	PHI:123169	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028s	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	phosphate acetyltransferase	loss of pathogenicity_reduced virulence	Gene deletion: full	35622226
C1_00067	EEO15930	73.1	398	3	103	3	399	2	396	2.5500000000000004e-212	587.0	A0A0H3Q0Y8	PHI:9843	ackA	666	PHI:9842_nan	Vibrio cholerae	SIO	infection	Flies	7227	Drosophila melanogaster (related: fruit fly)	Acetate kinase	unaffected pathogenicity	Gene deletion: full	30224439
C1_00073	ACD60708	43.0	398	0	227	3	400	8	405	3.56e-111	331.0	A0A0K0GPI8	PHI:9989	aspC (PXO_02420)	347	nan	Xanthomonas oryzae	pv. oryzae strain PXO99A	bacterial leaf blight	Monocots	4530	Oryza sativa (related: rice)	Aspartate aminotransferase	reduced virulence	Gene deletion: full; gene complementation	31847108
C1_00074	CAA52637	99.7	312	0	1	1	312	1	312	1.53e-220	600.0	P36771	PHI:7647	LrhA	562	nan	Escherichia coli	PA45B	urinary tract infection	Primates	9606	Homo sapiens (related: human)	Probable HTH-type transcriptional regulator	reduced virulence	Altered gene expression / gene regulation: overexpression	29066548
C1_00081	AE004693_1	67.0	908	2	297	1	908	1	905	0.0	1254.0	Q9I0J6	PHI:11247	nuoG	287	nan	Pseudomonas aeruginosa	PAO1	nosocomial infection	Rodents	10090	Mus musculus (related: house mouse)	NADH dehydrogenase	unaffected pathogenicity	Gene deletion: full; gene complementation	33534802
C1_00083	AE004693_3	86.0	172	0	24	9	180	11	182	7.190000000000002e-97	276.0	Q9I0J4	PHI:8937	nuoI (PA2644)	287	PHI:8938; PHI:8940; PHI:8941; PHI:8942; PHI:8943; PHI:8944; PHI:8945_PHI:8938_PHI:8939; PHI:8938	Pseudomonas aeruginosa	PAO1	nosocomial infection	Eudicots_Moths	4236_7137	Galleria mellonella (related: greater wax moth)_Lactuca sativa (related: garden lettuce)	NADH-quinone oxidoreductase	reduced virulence_unaffected pathogenicity	Gene deletion: full; gene complementation	30804898
C1_00084	AE004693_4	66.9	163	1	53	1	162	1	163	1.09e-65	197.0	Q9I0J3	PHI:8938	nuoJ (PA2645)	287	PHI:8937_PHI:8939; PHI:8937_PHI:8937; PHI:8940; PHI:8941; PHI:8942; PHI:8943; PHI:8944; PHI:8945	Pseudomonas aeruginosa	PAO1	nosocomial infection	Eudicots_Moths	4236_7137	Galleria mellonella (related: greater wax moth)_Lactuca sativa (related: garden lettuce)	NADH-quinone oxidoreductase	reduced virulence_unaffected pathogenicity	Gene deletion: full; gene complementation	30804898
C1_00101	ABR79228	51.6	126	0	61	1	126	1	126	3.0200000000000004e-35	116.0	A6TF94	PHI:7955	arnF	573	PHI:7949; PHI:7950; PHI:7951; PHI:7952; PHI:7953; PHI:7954	Klebsiella pneumoniae	52.145	pneumonia	Moths	7137	Galleria mellonella (related: greater wax moth)	Hypothetical protein	unaffected pathogenicity	Gene mutation	28652313
C1_00102	ABR79229	65.5	110	0	38	2	111	3	112	4.96e-48	147.0	A6TF95	PHI:7954	arnE	573	PHI:7949; PHI:7950; PHI:7951; PHI:7952; PHI:7953; PHI:7955	Klebsiella pneumoniae	52.145	pneumonia	Moths	7137	Galleria mellonella (related: greater wax moth)	Hypothetical protein	unaffected pathogenicity	Gene mutation	28652313
C1_00103	ABR79230	63.5	551	1	200	1	550	1	551	4.770000000000001e-251	697.0	A6TF96	PHI:7953	arnT	573	PHI:7949; PHI:7950; PHI:7951; PHI:7952; PHI:7954; PHI:7955	Klebsiella pneumoniae	52.145	pneumonia	Moths	7137	Galleria mellonella (related: greater wax moth)	4-Amino-4-deoxy-L-arabinose transferase	unaffected pathogenicity	Gene mutation	28652313
C1_00104	ABR79231	67.8	295	1	92	1	292	1	295	3.32e-148	416.0	A6TF97	PHI:7952	arnD	573	PHI:7949; PHI:7950; PHI:7951; PHI:7953; PHI:7954; PHI:7955	Klebsiella pneumoniae	52.145	pneumonia	Moths	7137	Galleria mellonella (related: greater wax moth)	Hypothetical protein	unaffected pathogenicity	Gene mutation	28652313
C1_00105	ABR79232	77.3	657	0	149	1	657	1	657	0.0	1056.0	A6TF98	PHI:7951	arnA	573	PHI:7949; PHI:7950; PHI:7952; PHI:7953; PHI:7954; PHI:7955	Klebsiella pneumoniae	52.145	pneumonia	Moths	7137	Galleria mellonella (related: greater wax moth)	Hypothetical protein	unaffected pathogenicity	Gene mutation	28652313
C1_00106	ACY89276	87.7	318	0	39	1	318	1	318	6.29e-201	551.0	D0ZPP5	PHI:2656	pmrF	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain JSG210	food poisoning	Rodents	10090	Mus musculus (related: house mouse)	4-amino-4-deoxy-L-arabinose (Ara4N) production	reduced virulence	Gene deletion: full	23166721
C1_00107	ABR79234	79.4	379	0	78	7	385	1	379	1.05e-221	609.0	A6TFA0	PHI:7949	arnB	573	PHI:7950; PHI:7951; PHI:7952; PHI:7953; PHI:7954; PHI:7955	Klebsiella pneumoniae	52.145	pneumonia	Moths	7137	Galleria mellonella (related: greater wax moth)	Putative aminotransferase	unaffected pathogenicity	Gene mutation	28652313
C1_00133	BAC98438	58.6	862	3	347	1	852	1	862	0.0	968.0	Q75WC1	PHI:849	GyrA	337	nan	Burkholderia glumae	M3	bacterial grain rot	Monocots	4530	Oryza sativa (related: rice)	DNA gyrase (bacterial topoisomerase II)	chemistry target: sensitivity to chemical_chemistry target: resistance to chemical	Sequence analysis of sensitive and resistant strains_Gene mutation: characterised	15345450
C1_00140	AAL21172	89.2	947	0	102	1	947	1	947	0.0	1665.0	P58662	PHI:3011	rcsC11	28901	PHI:3013_PHI:3012_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	food poisoning	Rodents	10090	Mus musculus (related: house mouse)	Sensor protein	reduced virulence_unaffected pathogenicity_increased virulence (hypervirulence)	Gene mutation	15469511
C1_00141	ACQ91082	99.1	216	0	2	1	216	1	216	1.61e-149	412.0	C4PCU2	PHI:3012	rcsB	28901	PHI:3011_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	food poisoning	Rodents	10090	Mus musculus (related: house mouse)	RcsA and RcsB form a complex to promote transcription of the genes for capsule synthesis.	unaffected pathogenicity	Gene mutation	15469511
C1_00142	FN434113	53.0	887	8	399	11	890	5	880	3.76e-311	877.0	D4HWX6	PHI:2501	rcsD	552	PHI:2499_nan	Erwinia amylovora	Ea321	fire blight	Eudicots	23211	Pyrus communis (related: pear)	Phosphorelay system	loss of pathogenicity	Gene disruption; gene complementation	19236575
C1_00143	AAN43817	95.2	375	1	16	1	375	1	373	7.5e-266	720.0	A0A2S4MYF8	PHI:9892	OmpC	623	PHI:9889_PHI:9891_nan	Shigella flexneri	serotype 2a strain 301	shigellosis	Primates	9606	Homo sapiens (related: human)	Outer membrane protein C	reduced virulence	Gene disruption	29858013
C1_00148	AGY90568	51.1	472	2	228	27	498	3	471	8.300000000000001e-165	476.0	Q5HDJ0	PHI:6190	Mqo	1280	PHI:6191_nan	Staphylococcus aureus	Newman	skin infection; food poisoning; respiratory disease	Rodents	10090	Mus musculus (related: house mouse)	malate-quinone oxidoreductases	reduced virulence	Gene mutation	26851155
C1_00149	CAH35049	44.4	142	2	77	20	160	37	177	9.7e-39	128.0	Q63W37	PHI:4101	Eco	28450	nan	Burkholderia pseudomallei	K96423	melioidosis	Rodents	10090	Mus musculus (related: house mouse)	serine protease inhibitor	reduced virulence	Gene mutation	24462575
C1_00151	AAC75268	99.4	164	0	1	1	164	1	164	5.56e-129	356.0	P0AAL0	PHI:10520	napF	562	PHI:10512; PHI:10513; PHI:10514; PHI:10515; PHI:10516; PHI:10517; PHI:10518; PHI:10519; PHI:10521; PHI:10522; PHI:10523; PHI:10524; PHI:10525; PHI:10526	Escherichia coli	CFT073	urinary tract infection	Rodents	10117	Rattus rattus (related: black rat)	Ferredoxin-type protein	reduced virulence	Gene deletion: full; gene complementation	32082279
C1_00152	AAC75267	100.0	87	0	0	1	87	1	87	5.05e-57	168.0	P0A9I5	PHI:10521	napD	562	PHI:10512; PHI:10513; PHI:10514; PHI:10515; PHI:10516; PHI:10517; PHI:10518; PHI:10519; PHI:10520; PHI:10522; PHI:10523; PHI:10524; PHI:10525; PHI:10526	Escherichia coli	CFT073	urinary tract infection	Rodents	10117	Rattus rattus (related: black rat)	Chaperone	reduced virulence	Gene deletion: full; gene complementation	32082279
C1_00153	AAC75266	100.0	828	0	0	1	828	1	828	0.0	1701.0	P33937	PHI:10522	napA	562	PHI:10512; PHI:10513; PHI:10514; PHI:10515; PHI:10516; PHI:10517; PHI:10518; PHI:10519; PHI:10520; PHI:10521; PHI:10523; PHI:10524; PHI:10525; PHI:10526	Escherichia coli	CFT073	urinary tract infection	Rodents	10117	Rattus rattus (related: black rat)	Periplasmic nitrate reductase	reduced virulence	Gene deletion: full; gene complementation	32082279
C1_00154	AAC75265	100.0	231	0	0	1	231	1	231	1.39e-171	469.0	P0AAL3	PHI:10986_PHI:10523	napG	562	PHI:10512; PHI:10513; PHI:10514; PHI:10515; PHI:10516; PHI:10517; PHI:10518; PHI:10519; PHI:10520; PHI:10521; PHI:10522; PHI:10524; PHI:10525; PHI:10526_nan	Escherichia coli	CFT073_PCN033	urinary tract infection_infection	Rodents	10090_10117	Rattus rattus (related: black rat)_Mus musculus (related: house mouse)	Ferredoxin-type protein	reduced virulence	Gene deletion: full_Gene deletion: full; gene complementation	32962530_32082279
C1_00155	AAC75264	100.0	287	0	0	1	287	1	287	8.18e-217	588.0	P33934	PHI:10524	napH	562	PHI:10512; PHI:10513; PHI:10514; PHI:10515; PHI:10516; PHI:10517; PHI:10518; PHI:10519; PHI:10520; PHI:10521; PHI:10522; PHI:10523; PHI:10525; PHI:10526	Escherichia coli	CFT073	urinary tract infection	Rodents	10117	Rattus rattus (related: black rat)	Ferredoxin-type protein 	reduced virulence	Gene deletion: full; gene complementation	32082279
C1_00156	AAC75263	99.3	149	0	1	1	149	1	149	3.07e-112	313.0	P0ABL3	PHI:10525	napB	562	PHI:10512; PHI:10513; PHI:10514; PHI:10515; PHI:10516; PHI:10517; PHI:10518; PHI:10519; PHI:10520; PHI:10521; PHI:10522; PHI:10523; PHI:10524; PHI:10526	Escherichia coli	CFT073	urinary tract infection	Rodents	10117	Rattus rattus (related: black rat)	Periplasmic nitrate reductase, electron transfer subunit	reduced virulence	Gene deletion: full; gene complementation	32082279
C1_00157	AAC75262	100.0	200	0	0	1	200	1	200	1.31e-156	429.0	P0ABL5	PHI:10526	napC	562	PHI:10512; PHI:10513; PHI:10514; PHI:10515; PHI:10516; PHI:10517; PHI:10518; PHI:10519; PHI:10520; PHI:10521; PHI:10522; PHI:10523; PHI:10524; PHI:10525	Escherichia coli	CFT073	urinary tract infection	Rodents	10117	Rattus rattus (related: black rat)	Cytochrome c-type protein	reduced virulence	Gene deletion: full; gene complementation	32082279
C1_00159	AIK80544	64.5	211	0	75	10	220	216	426	1.5500000000000003e-79	243.0	W1ATL3	PHI:7534	CcmA (VK055_1938)	573	PHI:7513; PHI:7514; PHI:7515; PHI:7516; PHI:7517; PHI:7518; PHI:7519; PHI:7520; PHI:7521; PHI:7522; PHI:7523; PHI:7524; PHI:7525; PHI:7526; PHI:7527; PHI:7528; PHI:7529; PHI:7530; PHI:7531; PHI:7532; PHI:7533; PHI:7535; PHI:7536; PHI:7537; PHI:7538	Klebsiella pneumoniae	KPPR1	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Heme ABC exporter, ATP-binding protein	unaffected pathogenicity	Gene deletion: full	28861522
C1_00166	nan	43.4	205	2	110	7	206	2	205	6.49e-45	147.0	A0A0K0GI78	PHI:9020	PXO_RS06090	347	nan	Xanthomonas oryzae	pv. oryzae strain PXO99A	bacterial leaf blight	Monocots	4530	Oryza sativa (related: rice)	Response regulator	reduced virulence	Gene mutation; gene complementation	30828283
C1_00172	ACT12677	69.9	93	0	28	1	93	1	93	2.68e-44	137.0	C6DEJ2	PHI:7469	RplY	554	nan	Pectobacterium carotovorum	subsp. carotovorum strain PccS1	soft rot	Eudicots_Monocots	3711_69721_94108	Zantedeschia aethiopica (related: arum-lily)_Zantedeschia elliottiana (no common name found)_Brassica rapa (related: field mustard)	50S Ribosomal protein	reduced virulence	Gene deletion: full; gene complementation	28853642
C1_00182	AAC75236	100.0	188	0	0	1	188	1	188	2.27e-133	369.0	P0AFV4	PHI:11093	MepS	562	nan	Escherichia coli	UTI89	infection	Rodents	10090	Mus musculus (related: house mouse)	Peptidoglycan DD-endopeptidase/peptidoglycan LD-carboxypeptidase	reduced virulence	Gene deletion: full; gene complementation	33391204
C1_00186	AAY49412	42.0	188	1	108	3	190	2	188	1.67e-46	149.0	Q4UU61	PHI:3953	XC_2359	339	nan	Xanthomonas campestris	pv. campestris strain 8004	black rot	Eudicots	3726	Raphanus sativus (related: radish)	Elongation factor P	reduced virulence	Gene mutation	23819805
C1_00189	BAB42180	43.0	79	1	42	290	368	6	81	3.86e-13	63.2	P99143	PHI:11269	ptsH	1280	nan_PHI:11270	Staphylococcus aureus	SA113_Newman	skin infection; food poisoning; respiratory disease	Rodents	10090	Mus musculus (related: house mouse)	Histidine-containing phosphocarrier protein	reduced virulence	Gene deletion: full; gene complementation	33668335
C1_00191	AAC66787	46.7	465	11	221	104	552	164	617	8.970000000000001e-79	258.0	O51369	PHI:6524	fruA1	139	nan	Borreliella burgdorferi	5A18NP1	lyme disease	Rodents	10090	Mus musculus (related: house mouse)	Pts system, fructose-specific iiabc component	unaffected pathogenicity	Gene mutation	26712207
C1_00199	CAG61680	46.3	283	4	147	2	280	11	292	2.98e-79	242.0	Q6FM27	PHI:3793	ANP1	5478	nan	Candida glabrata	CBS 138	disseminated candidiasis	Rodents	10090	Mus musculus (related: house mouse)	encode alpha -(1-6)-mannosyl-transferases	increased virulence (hypervirulence)	Gene disruption; gene complementation	23720756
C1_00201	AAL21105	91.3	287	0	25	1	287	1	287	1.42e-189	520.0	Q8ZNK8	PHI:11609	yeiE	28901	PHI:11610; PHI:11611_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain HA420	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Putative LysR family transcriptional regulator	reduced virulence	Gene deletion: full; gene complementation	34098734
C1_00231	AAL20314	44.3	228	0	127	4	231	3	230	1.02e-63	197.0	H9L471	PHI:602	orf242	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain SL1344	gastroenteritis	Rodents	10090	Mus musculus (related: house mouse)	nan	unaffected pathogenicity	Other evidence	16113260
C1_00261	BAB43211	42.2	287	3	161	1	284	1	285	1.8499999999999999e-69	215.0	P99075	PHI:6903	FbaA	1280	nan	Staphylococcus aureus	USA300 JE2	white muscardine	Moths	7137	Galleria mellonella (related: greater wax moth)	Fructose-bisphosphate aldolase	reduced virulence	Functional test in host: direct injection	27001537
C1_00272	ACY89976	90.9	77	0	7	5	81	1	77	2.13e-42	131.0	A0A0F6B629	PHI:11470	STM14_3563	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028s	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Putative transcriptional regulator	reduced virulence	Gene deletion: full; gene complementation	31832871
C1_00274	nan	41.0	227	3	127	12	233	5	229	1.03e-45	150.0	A0A0K0GIX3	PHI:9026	PXO_RS06785	347	nan	Xanthomonas oryzae	pv. oryzae strain PXO99A	bacterial leaf blight	Monocots	4530	Oryza sativa (related: rice)	Response regulator	unaffected pathogenicity	Gene mutation	30828283
C1_00278	CDN82752	99.7	1040	0	3	1	1040	1	1040	0.0	1900.0	W8ZK20	PHI:9198	yegN	562	PHI:9197_nan	Escherichia coli	serotype O157:H7 strain EDL933	urinary tract infection	Rodents	10090	Mus musculus (related: house mouse)	Multidrug efflux system subunit	reduced virulence	Gene deletion: full	31019555
C1_00286	CAR56115	41.5	164	2	91	678	838	249	410	5.92e-27	113.0	B4EGX2	PHI:8833	bcam2256	95486	nan	Burkholderia cenocepacia	H111	cystic fibrosis-like disease	Moths	7137	Galleria mellonella (related: greater wax moth)	Putative cyclic-di-GMP signaling protein	increased virulence (hypervirulence)	Gene mutation	30687272
C1_00288	BAD86762	95.3	193	0	9	1	193	1	193	5.73e-134	371.0	Q5KQZ9	PHI:2652	magA	573	nan	Klebsiella pneumoniae	NTUH-K2044	urinary tract infection; nosocomial pneumonia; abdominal infection	Rodents	10090	Mus musculus (related: house mouse)	Contributes to K1 capsular polysaccharide (CPS) biosynthesis	reduced virulence	Gene mutation: characterised	23118860
C1_00292	CAR54715	40.1	147	2	82	1	142	1	146	1.09e-26	96.3	B4EMX6	PHI:5296	BceD	95486	PHI:5295; PHI:5297	Burkholderia cenocepacia	K56-2	cystic fibrosis	Moths	7137	Galleria mellonella (related: greater wax moth)	Protein tyrosine phosphatases	reduced virulence	Gene mutation	26590274
C1_00293	X77921	53.0	713	2	330	1	710	1	711	9.63e-255	720.0	Q46631	PHI:2471	Ams	552	nan	Erwinia amylovora	Ea1189	fire blight	Eudicots	3750_23211	Malus domestica (related: apple)_Pyrus communis (related: pear)	Exopolysaccharides Amylovoran	loss of pathogenicity	Gene deletion: full	19821727
C1_00300	AAD07112	59.3	371	2	143	3	365	4	374	2.03e-155	441.0	O24885	PHI:12045	HP0044	210	nan	Helicobacter pylori	26695	gastric infection	Primates	9606	Homo sapiens (related: human)	GDP-D-mannose dehydratase	reduced virulence	Gene deletion: full; gene complementation	35052824
C1_00305	AAF93418	67.1	462	3	144	1	456	1	460	9.289999999999999e-229	633.0	Q06951	PHI:703	RfbB	666	nan	Vibrio cholerae	O395	cholera	Rodents	10090	Mus musculus (related: house mouse)	O-antigen biosynthesis	reduced virulence	Gene disruption	9916119
C1_00310	AAC75104	97.8	464	0	10	1	464	1	464	0.0	907.0	P71244	PHI:10990	wcaM	562	nan	Escherichia coli	PCN033	infection	Rodents	10090	Mus musculus (related: house mouse)	Colanic acid biosynthesis protein	unaffected pathogenicity	Gene deletion: full	32962530
C1_00322	ATZ51660	49.4	451	3	224	7	454	11	460	3.28e-154	446.0	A0A384JMC8	PHI:9835	bcpgd	40559	nan	Botrytis cinerea	B05.10	grey mold	Eudicots	29760	Vitis vinifera (related: wine grape)	6-phosphogluconate dehydrogenase	reduced virulence	Gene deletion: full; gene complementation	31230563
C1_00324	CAA78946	71.1	325	0	94	1	325	1	325	2.1999999999999998e-160	449.0	Q04866	PHI:3728	WzzST	28901	PHI:3727	Salmonella enterica	subsp. enterica serovar Typhimurium strain NCTC 12023	food poisoning	Moths	7137	Galleria mellonella (related: greater wax moth)	chain length determinant	loss of pathogenicity	Gene mutation	23951347
C1_00326	ABO13635	42.0	257	2	144	1	257	1	252	8.59e-69	211.0	A3M9P1	PHI:10701	hisF (A1S_3245)	470	nan	Acinetobacter baumannii	ATCC 17978	pneumonia	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Imidazole glycerol phosphate synthase cyclase subunit	reduced virulence_unaffected pathogenicity	Gene deletion: full; gene complementation	32840575
C1_00327	CBA21303	75.4	244	0	60	1	244	1	244	1.07e-134	377.0	D4HW76	PHI:9324	hisA	552	nan	Erwinia amylovora	HKN06P1	fire blight	Eudicots	3750_4097	Malus domestica (related: apple)_Nicotiana tabacum (related: common tobacco)	N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'-phosphoribosyl)-4-imidazolecarboxamide isomerase	reduced virulence_unaffected pathogenicity	Gene mutation	31152019
C1_00329	AEQ96355	52.2	372	3	155	6	355	5	375	3.41e-133	383.0	G7TE30	PHI:7790	HisB	347	nan	Xanthomonas oryzae	pv. oryzicola strain RS105	bacterial blight (rice)	Monocots	4530	Oryza sativa (related: rice)	Bifunctional enzyme implicated in the imidazoleglycerol-phosphate dehydratase activity	reduced virulence	Gene deletion: full; gene complementation	29256829
C1_00331	ACD58960	51.6	426	2	201	6	427	3	427	1.88e-131	384.0	A0A0K0GKU8	PHI:9983	hisD (PXO_00833)	347	nan	Xanthomonas oryzae	pv. oryzae strain PXO99A	bacterial leaf blight	Monocots	4530	Oryza sativa (related: rice)	Histidinol dehydrogenase	reduced virulence	Gene deletion: full; gene complementation	31847108
C1_00332	CAR33649	95.7	299	0	13	1	299	1	299	1.09e-202	554.0	B5QZL1	PHI:5109	prt	28901	nan	Salmonella enterica	subsp. enterica serovar Enteritidis strain P125109	colitis	Rodents	10090	Mus musculus (related: house mouse)	OAg biosynthesis	reduced virulence	Gene deletion: full; gene complementation	26346801
C1_00349	AFN68300	42.6	54	0	31	5	58	1066	1119	1.88e-07	48.1	I6ZFI8	PHI:9106	PksI	5599	nan	Alternaria alternata	ATCC 66981	brown spot	Eudicots	2706_4081_3750	Solanum lycopersicum (related: tomato)_Malus domestica (related: apple)_Citrus (no common name found)	Polyketide synthase	reduced virulence	Gene mutation	30947377
C1_00359	ATZ02919	54.5	55	0	25	156	210	148	202	5.41e-09	52.8	A0A0Z9GQC2	PHI:7986	vraR	1307	PHI:7985	Streptococcus suis	SC19	streptococcal toxic shock syndrome	Rodents	10090	Mus musculus (related: house mouse)	Response regulator	reduced virulence	Gene deletion: full; gene complementation	29471718
C1_00365	AAL20078	80.0	494	1	97	2	493	1	494	7.17e-290	791.0	Q8ZQ28	PHI:123210	clsC	28901	PHI:123209_PHI:123208; PHI:123209_nan_PHI:123208	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028s	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Cardiolipin synthase C	reduced virulence_unaffected pathogenicity	Gene deletion: full	35638781
C1_00367	CAC13110	76.2	500	0	119	1	500	23	522	1.88e-296	809.0	Q9F496	PHI:8654_PHI:5564	opgG	204038	PHI:8656_PHI:8655_nan	Dickeya dadantii	EC3937	soft rot	Eudicots	4113_13427	Cichorium intybus (related: chicory)_Solanum tuberosum (related: potato)	Glucans biosynthesis protein	reduced virulence	Gene mutation: characterised_Gene mutation	30425688_26790533
C1_00372	ATM55433	86.3	306	0	42	1	306	1	306	3.15e-210	573.0	W9BFU2	PHI:7946	lpxL1 (BN49_2155)	573	nan_PHI:7947	Klebsiella pneumoniae	52.145	pneumonia	Moths	7137	Galleria mellonella (related: greater wax moth)	Lipid A late acyltransferase	reduced virulence_unaffected pathogenicity	Gene deletion: full; gene complementation	28652313
C1_00374	AE004479_7	74.7	190	0	48	1	190	2	191	1.82e-104	296.0	Q9I690	PHI:3166	PA0423	287	nan	Pseudomonas aeruginosa	PAO1	nosocomial infection	Primates	9606	Homo sapiens (related: human)	factor responsible for cytotoxicity in lung epithelial cells	reduced virulence	Biochemical analysis_Gene mutation	25152458
C1_00380	CBA20393	71.8	348	1	96	1	346	1	348	5.58e-184	511.0	D4I0W8	PHI:9307	pyrC	552	nan	Erwinia amylovora	HKN06P1	fire blight	Eudicots	3750	Malus domestica (related: apple)	Dihydroorotase	reduced virulence	Gene mutation	31152019
C1_00400	AJF38888	55.0	549	5	240	1	546	1	545	2.4e-190	543.0	A0A0U1YUA0	PHI:6360	flgK	553	nan	Pantoea ananatis	LMG 20103	nan	Monocots	4679	Allium cepa (related: onion)	Flagellar motility	reduced virulence	Gene mutation; gene complementation	27226224
C1_00402	ADX16885	78.0	1075	13	214	1	1061	1	1067	0.0	1376.0	E8XEV4	PHI:3723	RNase E	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain SL1344	food poisoning	Moths	7137	Galleria mellonella (related: greater wax moth)	endoribonucleases	reduced virulence	Gene mutation; gene complementation	23913419
C1_00410	CAD14754	64.3	244	1	84	3	243	5	248	3.27e-99	288.0	Q8Y0J2	PHI:5271	fabG1	305	nan	Ralstonia solanacearum	GMI1000	bacterial wilt	Eudicots	4081	Solanum lycopersicum (related: tomato)	3-ketoacyl-acyl carrier protein reductase	lethal	Gene disruption; gene complementation	26490537
C1_00411	AE004613_3	49.3	73	0	37	1	73	1	73	8.43e-18	68.9	O52658	PHI:8556	Acp1 (PA1869)	287	PHI:8557_nan	Pseudomonas aeruginosa	PAO1	nosocomial infection	Rodents	10090	Mus musculus (related: house mouse)	Acyl carrier protein	increased virulence (hypervirulence)	Gene deletion: full; gene complementation	30294316
C1_00412	FGSG_07226	46.9	426	6	208	4	412	2	426	2.48e-125	367.0	I1RSU2	PHI:724_PHI:730	KSA1_PKS9	5518	nan	Fusarium graminearum	PH-1	fusarium ear blight	Monocots	4564	Triticum (related: wheat)	Polyketide synthase	unaffected pathogenicity	Gene disruption	16278459
C1_00418	ABX28234	49.8	500	8	225	1	474	1	500	1.07e-143	426.0	A8Z0F5	PHI:6308	glcA	1280	PHI:6309; PHI:6310; PHI:6311	Staphylococcus aureus	COL	skin infection; food poisoning; respiratory disease	Rodents	10090	Mus musculus (related: house mouse)	Glucose uptake protein	reduced virulence	Gene mutation; gene complementation	27329749
C1_00424	AAG06393	52.6	329	7	144	2	325	3	324	3.54e-101	300.0	Q9HZK0	PHI:123476	nagZ	287	nan_PHI:123478_PHI:123480_PHI:123479_PHI:123477	Pseudomonas aeruginosa	PAO1	nosocomial infection	Moths	7137	Galleria mellonella (related: greater wax moth)	permease	reduced virulence	Gene deletion: full_Gene deletion: full; other evidence: cloning	35171032
C1_00426	CEI15921	56.9	434	4	179	7	434	4	435	2.2900000000000003e-166	473.0	A0A069PYL4	PHI:11248	ndh	287	nan	Pseudomonas aeruginosa	PAO1	nosocomial infection	Rodents	10090	Mus musculus (related: house mouse)	NADH dehydrogenase	increased virulence (hypervirulence)	Gene deletion: full; gene complementation	33534802
C1_00429	AAL20143	91.8	85	0	7	1	85	1	85	5.35e-49	148.0	Q8ZQ03	PHI:11882	ycfR	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028	salmonellosis	Rodents_Primates	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Outer membrane protein	reduced virulence	Gene deletion: full	34659184
C1_00437	AAC78722	91.2	273	0	24	1	273	1	273	3.33e-184	505.0	P0A2F2	PHI:5572	cob	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	nicotinamide adenine dinucleotide (NAD + )-dependent deacetylase	unaffected pathogenicity	Gene mutation	26810370
C1_00440	ACL32924	53.4	341	1	156	8	348	12	349	6.299999999999999e-128	369.0	B8F6H2	PHI:11189	potD	738	nan	Glaesserella parasuis	SC1401	glasser's disease	Even-toed ungulates_Rodents	9823_10090	Sus scrofa (related: pig)_Mus musculus (related: house mouse)	Polyamine transport protein	reduced virulence	Gene deletion: full; gene complementation	33525975
C1_00443	AAL00050	53.1	288	3	127	16	301	4	285	2.61e-91	278.0	Q8DPC2	PHI:6319	potA	1313	PHI:6320; PHI:6321; PHI:6322	Streptococcus pneumoniae	serotype 4 strain TIGR4	pneumococcal pneumonia	Rodents	10090	Mus musculus (related: house mouse)	ABC transporter ATP-binding protein - spermidine/putrescine transport	reduced virulence	Gene mutation	27247105
C1_00446	BAA14391	100.0	486	0	0	1	486	1	486	0.0	934.0	P23837	PHI:10954	phoQ	562	nan	Escherichia coli	serotype O157:H7	infection	Rodents	10090	Mus musculus (related: house mouse)	Sensor protein	reduced virulence	Gene deletion: full; gene complementation	33173003
C1_00447	BAA14390	99.6	223	0	1	1	223	1	223	1.14e-157	434.0	P23836	PHI:10955	phoP	562	nan	Escherichia coli	serotype O157:H7	infection	Rodents	10090	Mus musculus (related: house mouse)	Transcriptional regulatory protein	reduced virulence	Gene deletion: full; gene complementation	33173003
C1_00455	ARA45326	65.7	242	0	83	1	242	1	242	1.75e-116	331.0	W9BEV6	PHI:11409	ycgE	573	nan	Klebsiella pneumoniae	ATCC 43816; MKP203	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	HTH-type transcriptional regulator 	reduced virulence	Gene deletion: full; gene complementation	31988174
C1_00467	ACD57940	53.0	83	2	37	1	83	1	81	9.29e-21	77.0	B2SRH1	PHI:123441	minE (PXO_04465)	347	PHI:123439; PHI:123440	Xanthomonas oryzae	pv. oryzae strain PXO99	bacterial leaf blight	Eudicots	4530_4097	Oryza sativa (related: rice)_Nicotiana tabacum (related: common tobacco)	Cell division topological specificity factor	reduced virulence_unaffected pathogenicity	Gene deletion: full; gene complementation	36013967
C1_00468	ACD57941	69.3	270	1	82	1	270	1	269	5.15e-131	370.0	A0A0K0GI74	PHI:123440	minD (PXO_04464)	347	PHI:123439; PHI:123441_nan	Xanthomonas oryzae	pv. oryzae strain PXO99	bacterial leaf blight	Eudicots	4530_4097	Oryza sativa (related: rice)_Nicotiana tabacum (related: common tobacco)	Septum site-determining protein MinD	reduced virulence_unaffected pathogenicity	Gene deletion: full; gene complementation	36013967
C1_00471	NP_415696	98.5	133	0	2	1	133	1	133	2.97e-91	258.0	P76002	PHI:2648	pliG	562	nan	Escherichia coli	CH2	colibacillosis; cellulitis; swollen head syndrome	Birds	9031	Gallus gallus (related: chicken)	Lysozyme inhibitor	unaffected pathogenicity	Gene deletion: full; gene complementation	23049900
C1_00481	ABR77737	90.4	239	0	23	1	239	1	239	2.09e-161	444.0	A6TAW6	PHI:11407	gntR	573	nan	Klebsiella pneumoniae	ATCC 43816; MKP203	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Fatty acid metabolism regulator	reduced virulence	Gene deletion: full; gene complementation	31988174
C1_00492	AAC74281	99.6	565	0	2	1	565	1	565	0.0	1157.0	P13482	PHI:10199	treA	562	nan	Escherichia coli	MT78	urinary tract infection	Birds_Rodents	9031_10090	Gallus gallus (related: chicken)_Mus musculus (related: house mouse)	Periplasmic Trehalase	reduced virulence_unaffected pathogenicity	Gene mutation	29844238
C1_00503	CAG45307	54.1	314	4	139	25	335	4	315	1.83e-120	348.0	Q5NH02	PHI:4732	FTT0673p/prsAp	263	nan	Francisella tularensis	SCHU S4	tularemia	Rodents	10090	Mus musculus (related: house mouse)	ribose phosphate pyrophosphokinase	unaffected pathogenicity	Gene mutation	25999917
C1_00507	CAD00621	50.6	354	2	171	8	358	4	356	1.86e-117	343.0	Q8Y4A8	PHI:9821	prfA (lmo2543)	1639	nan	Listeria monocytogenes	EGD-e	listeriosis	Primates	9606	Homo sapiens (related: human)	Peptide chain release factor 1	reduced virulence	Gene deletion: full	29715536
C1_00519	AAC74304	99.4	464	0	3	1	464	1	464	0.0	943.0	P39165	PHI:6184	ychO	562	nan	Escherichia coli	SEPT362	colibacillosis	Birds	9031	Gallus gallus (related: chicken)	invasin homolog	reduced virulence	Gene mutation; gene complementation	26965678
C1_00523	ACY88597	94.0	463	0	28	1	463	1	463	0.0	869.0	A0A0F6B259	PHI:123379	narK	28901	PHI:123380_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028s	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Nitrate/nitrite transporter	reduced virulence	Gene deletion: full	35806223
C1_00524	CAA34303	99.8	1247	0	3	1	1247	1	1247	0.0	2595.0	P09152	PHI:10512	narG	562	PHI:10513; PHI:10514; PHI:10515; PHI:10516; PHI:10517; PHI:10518; PHI:10519; PHI:10520; PHI:10521; PHI:10522; PHI:10523; PHI:10524; PHI:10525; PHI:10526	Escherichia coli	CFT073	urinary tract infection	Rodents	10117	Rattus rattus (related: black rat)	Respiratory nitrate reductase 1 alpha chain	reduced virulence	Gene deletion: full; gene complementation	32082279
C1_00525	CAA34304	99.8	512	0	1	1	512	1	512	0.0	1065.0	P11349	PHI:10513	narH	562	PHI:10512; PHI:10514; PHI:10515; PHI:10516; PHI:10517; PHI:10518; PHI:10519; PHI:10520; PHI:10521; PHI:10522; PHI:10523; PHI:10524; PHI:10525; PHI:10526	Escherichia coli	CFT073	urinary tract infection	Rodents	10117	Rattus rattus (related: black rat)	Respiratory nitrate reductase 1 beta chain	reduced virulence	Gene deletion: full; gene complementation	32082279
C1_00526	AAC74310	98.3	236	0	4	1	236	1	236	3.64e-165	454.0	P0AF26	PHI:10514	narJ	562	PHI:10512; PHI:10513; PHI:10515; PHI:10516; PHI:10517; PHI:10518; PHI:10519; PHI:10520; PHI:10521; PHI:10522; PHI:10523; PHI:10524; PHI:10525; PHI:10526	Escherichia coli	CFT073	urinary tract infection	Rodents	10117	Rattus rattus (related: black rat)	Nitrate reductase molybdenum cofactor assembly chaperone	reduced virulence	Gene deletion: full; gene complementation	32082279
C1_00527	AAC74311	99.6	225	0	1	1	225	1	225	7.42e-164	449.0	P11350	PHI:10515	narI	562	PHI:10512; PHI:10513; PHI:10514; PHI:10516; PHI:10517; PHI:10518; PHI:10519; PHI:10520; PHI:10521; PHI:10522; PHI:10523; PHI:10524; PHI:10525; PHI:10526	Escherichia coli	CFT073	urinary tract infection	Rodents	10117	Rattus rattus (related: black rat)	Respiratory nitrate reductase 1 gamma chain	reduced virulence	Gene deletion: full; gene complementation	32082279
C1_00533	Q7CQF1_SALTY	90.8	337	0	31	1	337	1	337	1.71e-225	615.0	Q7CQF1	PHI:2679	hnr	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028s	food poisoning	Rodents	10090	Mus musculus (related: house mouse)	Regulators of systemic infection	reduced virulence	Gene deletion: full; gene complementation	19229334
C1_00534	AAM41468	46.6	290	5	146	4	291	1	283	7.91e-76	232.0	Q8P8Q1	PHI:3112	galU	339	nan	Xanthomonas campestris	pv. campestris strain 8004	black rot	Eudicots	3712	Brassica oleracea (no common name found)	Uridine triphosphate (UTP)-glucose-1-phosphate uridylyltransferase	loss of pathogenicity	Gene mutation: characterised; gene complementation	25033927
C1_00535	CAA30530	100.0	137	0	0	1	137	1	137	2.49e-85	244.0	P0ACF8	PHI:6369	hns	562	nan	Escherichia coli	EDL933	urinary tract infection	Rodents	10090	Mus musculus (related: house mouse)	Global DNA-binding transcriptional dual regulator	increased virulence (hypervirulence)	Gene deletion: full	27173635
C1_00539	CYV08090	46.8	869	12	435	9	864	20	874	3.44e-256	736.0	A0A116Q7Z1	PHI:8932	adhE	1307	nan	Streptococcus suis	ZY05719	meningitis	Bony fishes_Primates	7955_9606	Homo sapiens (related: human)_Danio rerio (related: zebrafish)	Acetaldehyde-CoA/alcohol dehydrogenase	reduced virulence	Gene deletion: full	29247804
C1_00546	AAC66722	50.0	264	1	130	15	276	2	265	2.99e-83	252.0	H7C7Q3	PHI:7820	oppD (bb0334)	139	PHI:7821	Borreliella burgdorferi	B31 5A18 NP1	lyme disease	Rodents	10090	Mus musculus (related: house mouse)	Oligopepeptide (Opp) transporter that drives transport by hydrolyzing ATP	reduced virulence	Gene mutation; chemical complementation	29259089
C1_00549	AAL20657	94.4	486	0	27	1	486	1	486	0.0	929.0	P63798	PHI:123208	clsA	28901	PHI:123209_PHI:123209; PHI:123210_nan_PHI:123210	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028s	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Cardiolipin synthase A	reduced virulence_unaffected pathogenicity	Gene deletion: full	35638781
C1_00564	CAA48498	69.5	246	6	56	13	246	1	239	1.96e-86	255.0	P45610	PHI:6651	tonB	573	PHI:6652; PHI:6653_nan	Klebsiella pneumoniae	KPPR1	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	siderophores synthesis	reduced virulence_unaffected pathogenicity	Gene mutation	27624128
C1_00569	AEQ96593	53.1	160	0	75	9	168	72	231	1.96e-51	162.0	G7TG38	PHI:4137	xrp8	347	nan	Xanthomonas oryzae	pv. oryzicola strain RS105	leaf blight	Monocots	4530	Oryza sativa (related: rice)	Type III effector	effector (plant avirulence determinant)	Gene mutation; gene complementation	24675748
C1_00571	CAR33117	93.3	30	0	2	1	30	1	30	1.31e-13	57.0	A0A6C7HPB2	PHI:10387	SEN1538	28901	nan	Salmonella enterica	subsp. enterica serovar Enteritidis strain P125109	salmonellosis	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Conserved hypothetical protein	reduced virulence	Gene deletion: full; gene complementation	32193977
C1_00573	CBA20869	89.4	395	0	42	3	397	2	396	2.8999999999999997e-263	715.0	D4I3E6	PHI:9321	trpB	552	nan	Erwinia amylovora	HKN06P1	fire blight	Eudicots	3750	Malus domestica (related: apple)	Tryptophan synthase beta chain	reduced virulence	Gene mutation	31152019
C1_00585	AE004601_8	63.7	322	0	117	1	322	1	322	1.03e-150	424.0	G3XCU6	PHI:8764	cysB	287	nan	Pseudomonas aeruginosa	PAO1	infection	Rodents	10090	Mus musculus (related: house mouse)	LysR-type transcriptional regulator	reduced virulence	Gene deletion: full; gene complementation	30618115
C1_00590	CAG59081	44.1	177	4	78	41	196	106	282	1.17e-36	127.0	Q6FUD7	PHI:12190	RIB1 (CAGL0F04279g)	5478	nan	Candida glabrata	KUE100-1	invasive candidiasis	Moths_Rodents	10090_7091	Bombyx mori (related: domestic silkworm)_Mus musculus (related: house mouse)	GTP cyclohydrolase-2	reduced virulence	Gene deletion: full	35308400
C1_00599	AAN80222	98.5	661	0	10	1	661	1	661	0.0	1278.0	A0A0H2V722	PHI:123407	yciR	562	nan	Escherichia coli	CFT073	urinary tract infection	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	3'-Phosphodiesterase	reduced virulence	Gene deletion: full; gene complementation	35923408
C1_00602	ABD30072	43.6	250	2	138	4	251	4	252	1.27e-67	208.0	Q2FZQ3	PHI:7915	fabI	1280	PHI:7916_nan_PHI:7916; PHI:7917	Staphylococcus aureus	F-182_NCTC 13277_SAR17_Newman	reduced virulence_nan	Moths	7137	Galleria mellonella (related: greater wax moth)	Enoyl-ACP reductase	reduced virulence_unaffected pathogenicity	Gene mutation	29497096
C1_00614	AAO53646	58.3	489	1	200	9	493	9	497	3.22e-202	569.0	Q88BC5	PHI:7787	AldA (PSPTO_0092)	317	PHI:7788_nan	Pseudomonas syringae	pv. tomato strain DC3000	bacterial speck (tomato)	Eudicots	3702	Arabidopsis thaliana (related: thale cress)	Indole-3-acetaldehyde dehydrogenase	reduced virulence	Gene disruption_Gene disruption; gene complementation	29293681
C1_00616	CAD13557	70.3	417	1	123	3	419	9	424	1.35e-205	572.0	Q8Y3F1	PHI:11791	gabT (RSc0029)	305	nan	Ralstonia solanacearum	GMI1000	bacterial wilt	Eudicots	4081	Solanum lycopersicum (related: tomato)	4-Aminobutyrate aminotransaminase	reduced virulence	Gene deletion: full; gene complementation	34604716
C1_00618	ACY88508	91.4	222	0	19	1	222	1	222	1.11e-127	358.0	A0A0F6B1X1	PHI:7657	pspA	28901	PHI:7658; PHI:7659; PHI:7660_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ST4/74	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Phage-shock protein	reduced virulence_unaffected pathogenicity	Gene mutation; gene complementation	24713356
C1_00619	ACY88507	89.2	74	0	8	1	74	1	74	1.49e-41	128.0	A0A0F6B1X0	PHI:7658	pspB	28901	PHI:7657; PHI:7659; PHI:7660_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ST4/74	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Phage-shock protein	reduced virulence	Gene mutation; gene complementation	24713356
C1_00620	ACY88506	84.0	119	0	19	1	119	1	119	4.22e-64	189.0	A0A0F6B1W9	PHI:7659	pspC	28901	PHI:7657; PHI:7658; PHI:7660_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ST4/74	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Phage-shock protein	reduced virulence_unaffected pathogenicity	Gene mutation; gene complementation	24713356
C1_00621	ACY88505	87.5	72	0	9	1	72	1	72	6.689999999999999e-42	129.0	A0A0F6B1W8	PHI:7660	pspD	28901	PHI:7657; PHI:7658; PHI:7659_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ST4/74	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Phage-shock protein	reduced virulence_unaffected pathogenicity	Gene mutation; gene complementation	24713356
C1_00638	CAL20972	70.6	517	2	144	1	510	1	516	5.1399999999999994e-263	725.0	Q0WEH7	PHI:4563	TyrR	632	nan	Yersinia pestis	201	plague	Rodents	10090	Mus musculus (related: house mouse)	regulator of aromatic amino acid metabolism	reduced virulence	Gene deletion: full; gene complementation	25729381
C1_00645	AE005205_3	40.6	293	2	172	2	294	3	293	2.22e-65	205.0	Q8X6J9	PHI:9508	ovrB (Z0346)	562	nan	Escherichia coli	serotype O157	hemorrhagic colitis; hemolytic uremic syndrome	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	LysR-type transcriptional regulator	reduced virulence	Gene mutation; gene complementation	31502495
C1_00650	AAA87981	100.0	250	0	0	1	250	1	250	7.39e-181	494.0	P0A9E5	PHI:7248_PHI:4876	fnr_FNR	562	nan	Escherichia coli	CFT073_APEC O1	infection_colibacillosis	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	global regulator_Transcription factor, is a global regulator of pathways meant to facilitate gene expression	reduced virulence	Gene deletion: full; gene complementation_Gene mutation; gene complementation	25245807_28690981
C1_00657	CAG76749	42.8	166	2	88	248	410	368	529	1.34e-30	121.0	Q6D0E8	PHI:7691	ECA3851	29471	nan	Pectobacterium atrosepticum	SCRI 1043	soft rot (potato); blackleg disease (potato)	Eudicots	4113	Solanum tuberosum (related: potato)	Cyclic-di-GMP signalling protein	reduced virulence	Altered gene expression / gene regulation: overexpression	24760967
C1_00723	AAK45660	40.0	115	3	65	347	459	187	299	2.25e-13	70.9	P64825	PHI:3873	dgc	1773	nan	Mycobacterium tuberculosis	H37Rv	tuberculosis	Rodents	10090	Mus musculus (related: house mouse)	degradation of the ubiquitous bacterial second messenger, cyclic di-GMP	unaffected pathogenicity	Gene mutation	24080120
C1_00727	HAD6865018	67.3	248	0	81	1	248	1	248	7.700000000000001e-134	375.0	A0A719CV62	PHI:123525	ompV	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain SL1344	salmonellosis	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	MipA/OmpV family protein	reduced virulence	Gene deletion: full; gene complementation	32017350
C1_00731	ABJ53896	47.7	132	1	68	4	134	169	300	2.7099999999999997e-38	130.0	Q04LM6	PHI:3913	SpMsrAB2	1313	nan	Streptococcus pneumoniae	serotype 2 strain D39	pneumonia; otitis media; septicemia; meningitis	Rodents	10090	Mus musculus (related: house mouse)	methionine sulfoxide reductase	reduced virulence	Gene mutation	24136784
C1_00739	ACY88154	40.0	70	1	38	1	66	1	70	5.79e-09	54.3	A0A0F6B0X6	PHI:10112	STM14_RS07765 (orf408)	28901	PHI:10099; PHI:10100; PHI:10101; PHI:10102; PHI:10103; PHI:10104; PHI:10105; PHI:10106; PHI:10107; PHI:10108; PHI:10109; PHI:10110; PHI:10111; PHI:10113; PHI:10114; PHI:10115; PHI:10116; PHI:10117; PHI:10118; PHI:10119; PHI:10120; PHI:10121; PHI:10122; PHI:10123; PHI:10124; PHI:10125; PHI:10126; PHI:10127; PHI:10128; PHI:10129; PHI:10130; PHI:10131; PHI:10132; PHI:10133; PHI:10134; PHI:10135; PHI:10136; PHI:10137; PHI:10138; PHI:10139; PHI:10140; PHI:10141; PHI:10142; PHI:10143; PHI:10144; PHI:10145; PHI:10146; PHI:10147; PHI:10148; PHI:10149; PHI:10150; PHI:10151; PHI:10152	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	DeoR family transcriptional regulator	reduced virulence	Gene deletion: full	32038592
C1_00751	CAH34326	49.0	51	1	25	9	59	13	62	5.9e-07	44.3	Q63Y51	PHI:10934	plc2 (bpsl0337)	28450	PHI:10933; PHI:10935_nan_PHI:10933	Burkholderia pseudomallei	K96243	melioidosis	Primates_Moths_Rodents	7137_10090_9606	Homo sapiens (related: human)_Galleria mellonella (related: greater wax moth)_Mus musculus (related: house mouse)	MutT/NUDIX family protein	reduced virulence_unaffected pathogenicity	Gene deletion: full	33159122
C1_00775	BAC61949	43.4	53	0	30	219	271	209	261	1.76e-07	49.7	Q87IK0	PHI:8742	QsvR (VPA0606)	670	nan	Vibrio parahaemolyticus	RIMD 2210633	gastrointestinal disease	 hares_Rabbits _Primates_Rodents	10090_9986_9606	Homo sapiens (related: human)_Oryctolagus cuniculus (related: rabbit)_Mus musculus (related: house mouse)	Putative AraC-type regulatory protein	reduced virulence	Gene deletion: full; gene complementation	30623553
C1_00778	AAL20243	87.3	750	1	93	4	753	3	750	0.0	1341.0	H9L460	PHI:11380	katE	28901	PHI:11381; PHI:11382	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028	salmonellosis	Moths	7137	Galleria mellonella (related: greater wax moth)	Catalase	reduced virulence	Gene deletion: full	33732665
C1_00799	CAH19577	42.9	282	7	147	52	323	50	327	2.8999999999999996e-55	181.0	Q66FJ9	PHI:7908	hmuU	633	PHI:7905; PHI:7906; PHI:7907; PHI:7909_PHI:7906; PHI:7907; PHI:7909	Yersinia pseudotuberculosis	IP2666	zoonotic infection	Even-toed ungulates	9940	Ovis aries (related: sheep)	Hemin import ATP-binding protein	unaffected pathogenicity	Gene deletion: full	29520342
C1_00800	EAK94921	47.8	159	2	64	11	169	10	149	8.73e-44	141.0	Q59WW7	PHI:4936	gpx31	5476	nan_PHI:4937; PHI:4938	Candida albicans	BWP17	disseminated candidiasis	Birds	9031	Gallus gallus (related: chicken)	Glutathione peroxidase	unaffected pathogenicity	Gene mutation; gene complementation	24625675
C1_00809	AAL20275	83.0	542	0	92	1	542	1	542	0.0	936.0	Q8ZPS2	PHI:9092	ydiD	28901	PHI:9093_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain IR715	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Plant pathogenicity factor-like protein	reduced virulence	Gene deletion: full; gene complementation	29447698
C1_00812	AAY50657	44.3	122	1	67	190	311	194	314	2.63e-25	101.0	Q4UQL6	PHI:3957	XC_3615	339	nan	Xanthomonas campestris	pv. campestris strain 8004	black rot	Eudicots	3726	Raphanus sativus (related: radish)	Electron transfer flavoprotein alpha subunit	reduced virulence	Gene mutation	23819805
C1_00818	CNQ81581	80.6	252	0	49	1	252	1	252	4.18e-140	392.0	A0A0U1GNF3	PHI:7062	aroD	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain BRD509	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	3-Dehydroquinate dehydratase	unaffected pathogenicity	Gene mutation	27456828
C1_00828	ACY88142	96.0	495	0	20	1	495	1	495	0.0	969.0	A0A0F6B0W4	PHI:6893_PHI:10099	STM14_RS07705 (sufB)_sufB	28901	PHI:10100; PHI:10101; PHI:10102; PHI:10103; PHI:10104; PHI:10105; PHI:10106; PHI:10107; PHI:10108; PHI:10109; PHI:10110; PHI:10111; PHI:10112; PHI:10113; PHI:10114; PHI:10115; PHI:10116; PHI:10117; PHI:10118; PHI:10119; PHI:10120; PHI:10121; PHI:10122; PHI:10123; PHI:10124; PHI:10125; PHI:10126; PHI:10127; PHI:10128; PHI:10129; PHI:10130; PHI:10131; PHI:10132; PHI:10133; PHI:10134; PHI:10135; PHI:10136; PHI:10137; PHI:10138; PHI:10139; PHI:10140; PHI:10141; PHI:10142; PHI:10143; PHI:10144; PHI:10145; PHI:10146; PHI:10147; PHI:10148; PHI:10149; PHI:10150; PHI:10151; PHI:10152_PHI:6893	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s_subsp. enterica serovar Typhimurium strain 12023	salmonellosis_infection	Eudicots_Rodents	4236_10090	Lactuca sativa (related: garden lettuce)_Mus musculus (related: house mouse)	Sulfur mobilization_Fe-S cluster assembly protein	reduced virulence_unaffected pathogenicity	Gene deletion: full_Gene mutation	27704705_32038592
C1_00829	ACY88143	92.3	248	0	19	1	248	1	248	1.58e-165	456.0	A0A0F6B0W5	PHI:10100	STM14_RS07710 (sufC)	28901	PHI:10099; PHI:10101; PHI:10102; PHI:10103; PHI:10104; PHI:10105; PHI:10106; PHI:10107; PHI:10108; PHI:10109; PHI:10110; PHI:10111; PHI:10112; PHI:10113; PHI:10114; PHI:10115; PHI:10116; PHI:10117; PHI:10118; PHI:10119; PHI:10120; PHI:10121; PHI:10122; PHI:10123; PHI:10124; PHI:10125; PHI:10126; PHI:10127; PHI:10128; PHI:10129; PHI:10130; PHI:10131; PHI:10132; PHI:10133; PHI:10134; PHI:10135; PHI:10136; PHI:10137; PHI:10138; PHI:10139; PHI:10140; PHI:10141; PHI:10142; PHI:10143; PHI:10144; PHI:10145; PHI:10146; PHI:10147; PHI:10148; PHI:10149; PHI:10150; PHI:10151; PHI:10152	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Fe-S cluster assembly ATPase	reduced virulence	Gene deletion: full	32038592
C1_00830	ACY88144	79.3	421	0	87	1	421	1	421	6.26e-246	674.0	A0A0F6B0W6	PHI:10101	STM14_RS07715 (sufD)	28901	PHI:10099; PHI:10100; PHI:10102; PHI:10103; PHI:10104; PHI:10105; PHI:10106; PHI:10107; PHI:10108; PHI:10109; PHI:10110; PHI:10111; PHI:10112; PHI:10113; PHI:10114; PHI:10115; PHI:10116; PHI:10117; PHI:10118; PHI:10119; PHI:10120; PHI:10121; PHI:10122; PHI:10123; PHI:10124; PHI:10125; PHI:10126; PHI:10127; PHI:10128; PHI:10129; PHI:10130; PHI:10131; PHI:10132; PHI:10133; PHI:10134; PHI:10135; PHI:10136; PHI:10137; PHI:10138; PHI:10139; PHI:10140; PHI:10141; PHI:10142; PHI:10143; PHI:10144; PHI:10145; PHI:10146; PHI:10147; PHI:10148; PHI:10149; PHI:10150; PHI:10151; PHI:10152	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Fe-S cluster assembly protein	reduced virulence	Gene deletion: full	32038592
C1_00831	ACY88145	87.4	406	0	51	1	406	1	406	1.6199999999999998e-267	727.0	A0A0F6B0W7	PHI:10102	STM14_RS07720 (sufS)	28901	PHI:10099; PHI:10100; PHI:10101; PHI:10103; PHI:10104; PHI:10105; PHI:10106; PHI:10107; PHI:10108; PHI:10109; PHI:10110; PHI:10111; PHI:10112; PHI:10113; PHI:10114; PHI:10115; PHI:10116; PHI:10117; PHI:10118; PHI:10119; PHI:10120; PHI:10121; PHI:10122; PHI:10123; PHI:10124; PHI:10125; PHI:10126; PHI:10127; PHI:10128; PHI:10129; PHI:10130; PHI:10131; PHI:10132; PHI:10133; PHI:10134; PHI:10135; PHI:10136; PHI:10137; PHI:10138; PHI:10139; PHI:10140; PHI:10141; PHI:10142; PHI:10143; PHI:10144; PHI:10145; PHI:10146; PHI:10147; PHI:10148; PHI:10149; PHI:10150; PHI:10151; PHI:10152	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Cysteine desulfurase	reduced virulence	Gene deletion: full	32038592
C1_00832	ACY88146	87.7	138	0	17	1	138	1	138	2.58e-83	239.0	A0A0F6B0W8	PHI:10103	STM14_RS07725 (ynhA/sufE)	28901	PHI:10099; PHI:10100; PHI:10101; PHI:10102; PHI:10104; PHI:10105; PHI:10106; PHI:10107; PHI:10108; PHI:10109; PHI:10110; PHI:10111; PHI:10112; PHI:10113; PHI:10114; PHI:10115; PHI:10116; PHI:10117; PHI:10118; PHI:10119; PHI:10120; PHI:10121; PHI:10122; PHI:10123; PHI:10124; PHI:10125; PHI:10126; PHI:10127; PHI:10128; PHI:10129; PHI:10130; PHI:10131; PHI:10132; PHI:10133; PHI:10134; PHI:10135; PHI:10136; PHI:10137; PHI:10138; PHI:10139; PHI:10140; PHI:10141; PHI:10142; PHI:10143; PHI:10144; PHI:10145; PHI:10146; PHI:10147; PHI:10148; PHI:10149; PHI:10150; PHI:10151; PHI:10152	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Cysteine desulfuration protein	reduced virulence	Gene deletion: full	32038592
C1_00833	ACY88147	85.6	334	1	47	1	334	1	333	2.51e-207	568.0	A0A0F6B0W9	PHI:10104	STM14_RS07730 (ynhG)	28901	PHI:10099; PHI:10100; PHI:10101; PHI:10102; PHI:10103; PHI:10105; PHI:10106; PHI:10107; PHI:10108; PHI:10109; PHI:10110; PHI:10111; PHI:10112; PHI:10113; PHI:10114; PHI:10115; PHI:10116; PHI:10117; PHI:10118; PHI:10119; PHI:10120; PHI:10121; PHI:10122; PHI:10123; PHI:10124; PHI:10125; PHI:10126; PHI:10127; PHI:10128; PHI:10129; PHI:10130; PHI:10131; PHI:10132; PHI:10133; PHI:10134; PHI:10135; PHI:10136; PHI:10137; PHI:10138; PHI:10139; PHI:10140; PHI:10141; PHI:10142; PHI:10143; PHI:10144; PHI:10145; PHI:10146; PHI:10147; PHI:10148; PHI:10149; PHI:10150; PHI:10151; PHI:10152	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Murein L,D-transpeptidase	reduced virulence	Gene deletion: full	32038592
C1_00834	ACY88149	96.2	78	0	3	1	78	1	78	6.59e-31	102.0	A0A0F6B0X1	PHI:10106	STM14_RS07740 (lpp)	28901	PHI:10099; PHI:10100; PHI:10101; PHI:10102; PHI:10103; PHI:10104; PHI:10105; PHI:10107; PHI:10108; PHI:10109; PHI:10110; PHI:10111; PHI:10112; PHI:10113; PHI:10114; PHI:10115; PHI:10116; PHI:10117; PHI:10118; PHI:10119; PHI:10120; PHI:10121; PHI:10122; PHI:10123; PHI:10124; PHI:10125; PHI:10126; PHI:10127; PHI:10128; PHI:10129; PHI:10130; PHI:10131; PHI:10132; PHI:10133; PHI:10134; PHI:10135; PHI:10136; PHI:10137; PHI:10138; PHI:10139; PHI:10140; PHI:10141; PHI:10142; PHI:10143; PHI:10144; PHI:10145; PHI:10146; PHI:10147; PHI:10148; PHI:10149; PHI:10150; PHI:10151; PHI:10152	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Murein lipoprotein	reduced virulence	Gene deletion: full	32038592
C1_00835	ACY88150	95.7	470	0	20	1	470	1	470	1.36e-319	864.0	A0A0F6B0X2	PHI:10107	STM14_RS07745 (pykF)	28901	PHI:10099; PHI:10100; PHI:10101; PHI:10102; PHI:10103; PHI:10104; PHI:10105; PHI:10106; PHI:10108; PHI:10109; PHI:10110; PHI:10111; PHI:10112; PHI:10113; PHI:10114; PHI:10115; PHI:10116; PHI:10117; PHI:10118; PHI:10119; PHI:10120; PHI:10121; PHI:10122; PHI:10123; PHI:10124; PHI:10125; PHI:10126; PHI:10127; PHI:10128; PHI:10129; PHI:10130; PHI:10131; PHI:10132; PHI:10133; PHI:10134; PHI:10135; PHI:10136; PHI:10137; PHI:10138; PHI:10139; PHI:10140; PHI:10141; PHI:10142; PHI:10143; PHI:10144; PHI:10145; PHI:10146; PHI:10147; PHI:10148; PHI:10149; PHI:10150; PHI:10151; PHI:10152	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Pyruvate kinase I	reduced virulence	Gene deletion: full	32038592
C1_00836	AAL20312	87.0	69	0	9	1	69	1	69	4.0900000000000004e-37	117.0	P0A1T4	PHI:603	orf70	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain SL1344	gastroenteritis	Rodents	10090	Mus musculus (related: house mouse)	nan	unaffected pathogenicity	Other evidence	16113260
C1_00840	AAC74741	99.5	222	0	1	1	222	1	222	1.24e-174	476.0	P77375	PHI:10998	ydhX	562	nan	Escherichia coli	PCN033	infection	Rodents	10090	Mus musculus (related: house mouse)	Putative 4Fe-4S ferredoxin-like protein	unaffected pathogenicity	Gene deletion: full	32962530
C1_00850	CAM65755	49.4	395	6	176	1	371	81	475	4.43e-127	373.0	A4HTK3	PHI:2643	CFAS	5671	nan	Leishmania infantum	JPCM5	leishmaniasis	Rodents	10090	Mus musculus (related: house mouse)	Cyclopropane fatty acid synthetase	reduced virulence	Gene deletion: full; gene complementation	23251490
C1_00852	DQ778942	50.9	57	0	28	6	62	19	75	1.15e-06	47.8	Q0GPY7	PHI:3491	lhnR	373	nan	Agrobacterium vitis	F2/5	nan	Eudicots	29760	Vitis vinifera (related: wine grape)	Tobacco hypersensitive responses, grape necrosis	reduced virulence	Gene disruption; gene complementation	22212449
C1_00856	AAL20353	94.8	193	0	10	1	193	1	193	2.26e-140	387.0	P0A2F4	PHI:11377	sodB	28901	PHI:11376_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028	salmonellosis	Moths	7137	Galleria mellonella (related: greater wax moth)	Cytoplasmic superoxide dismutase	reduced virulence_increased virulence (hypervirulence)	Gene deletion: full	33732665
C1_00858	AFR93743	49.4	87	0	44	14	100	147	233	1.98e-24	91.7	J9VHR2	PHI:8615	Grx4 (CNAG_02950)	5207	nan	Cryptococcus neoformans	H99	meningoencephalitis	Rodents	10090	Mus musculus (related: house mouse)	Monothiol glutaredoxin	loss of pathogenicity	Gene deletion: partial; gene complementation	30514787
C1_00866	AAC13559	82.1	173	0	31	1	173	1	173	3.07e-101	287.0	O68901	PHI:11379_PHI:9809	SodCII_sodCII	28901	PHI:11378_PHI:9808	Salmonella enterica	subsp. enterica serovar Typhimurium strain LT2_subsp. enterica serovar Typhimurium strain ATCC 14028	salmonellosis	Moths_Rodents	7137_10090	Galleria mellonella (related: greater wax moth)_Mus musculus (related: house mouse)	Superoxide dismutase [Cu-Zn] 2_Periplasmic superoxide dismutase	reduced virulence_unaffected pathogenicity	Gene deletion: full_Gene deletion: full; gene complementation	30249808_33732665
C1_00870	SLYA_SALTY	89.4	142	0	15	1	142	1	142	2.42e-84	242.0	P40676	PHI:2678	slyA	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028s	food poisoning	Rodents	10090	Mus musculus (related: house mouse)	Regulators of systemic infection	reduced virulence	Gene deletion: full; gene complementation	19229334
C1_00873	ADT75274	100.0	107	0	0	1	107	1	107	1.1e-76	219.0	E0IWR8	PHI:2646	MliC	562	PHI:2647_nan	Escherichia coli	CH2	colibacillosis; cellulitis; swollen head syndrome	Birds	9031	Gallus gallus (related: chicken)	Lysozyme inhibitor	reduced virulence_unaffected pathogenicity	Gene deletion: full; gene complementation	23049900
C1_00886	AE004724_12	42.2	199	2	105	1	189	1	199	1.67e-39	132.0	Q9HZL0	PHI:8941	nqrE (PA2995)	287	PHI:8939; PHI:8940; PHI:8942; PHI:8943; PHI:8944; PHI:8945_PHI:8937; PHI:8938; PHI:8940; PHI:8942; PHI:8943; PHI:8944; PHI:8945_PHI:8940; PHI:8942; PHI:8943; PHI:8944; PHI:8945	Pseudomonas aeruginosa	PAO1	nosocomial infection	Eudicots_Moths	4236_7137	Galleria mellonella (related: greater wax moth)_Lactuca sativa (related: garden lettuce)	Na(+)-translocating NADH-quinone reductase	unaffected pathogenicity	Gene deletion: full; gene complementation	30804898
C1_00888	ERO58913	74.3	70	0	18	1	70	1	70	9.59e-39	121.0	U6ZHS1	PHI:4179	expI	1089444	nan	Dickeya solani	IFB0123	soft rot	Eudicots	4113	Solanum tuberosum (related: potato)	synthesis and perception of signaling molecules	reduced virulence	Gene mutation	24625032
C1_00892	AAA24098	99.6	530	0	2	1	530	1	530	0.0	1029.0	P19642	PHI:4631	pafP	562	PHI:4630_nan	Escherichia coli	CFT073	urinary tract infection	Rodents	10090	Mus musculus (related: house mouse)	Transcription Regulator	reduced virulence	Gene deletion: full; gene complementation	25069986
C1_00896	VTT12284	56.8	139	1	59	454	591	8	146	1.7100000000000001e-49	167.0	A0A4V0ETS4	PHI:123248	uidA (B9H01_RS05640)	1307	nan	Streptococcus suis	SC19	meningitis, endocarditis; sepsis	Moths	7137	Galleria mellonella (related: greater wax moth)	Beta-glucuronidase	reduced virulence	Gene mutation	35630313
C1_00901	AAL20388	95.8	543	0	23	1	543	1	543	0.0	1051.0	P40720	PHI:10046	fumA	28901	PHI:10047; PHI:10048; PHI:10049_PHI:10047; PHI:10048; PHI:10051_PHI:10047; PHI:10048_PHI:10047; PHI:10048; PHI:10050_PHI:10047; PHI:10048; PHI:10051; PHI:10049_PHI:10047; PHI:10048; PHI:10051; PHI:10050	Salmonella enterica	subsp. enterica serovar Typhimurium strain NCTC 12023	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Fumarate hydratase class I, aerobic	reduced virulence	Gene mutation; gene complementation	31826974
C1_00902	AAL20389	91.6	467	0	39	1	467	1	467	4.42e-312	845.0	Q8ZPL7	PHI:10048	fumC	28901	PHI:10046; PHI:10047; PHI:10051; PHI:10049_PHI:10046; PHI:10047; PHI:10051; PHI:10050_PHI:10046; PHI:10047; PHI:10050_PHI:10046; PHI:10047; PHI:10049_PHI:10046; PHI:10047; PHI:10051_PHI:10046; PHI:10047	Salmonella enterica	subsp. enterica serovar Typhimurium strain NCTC 12023	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Fumarate hydratase class II	reduced virulence	Gene mutation; gene complementation	31826974
C1_00905	AJF56459	99.6	239	0	1	1	239	1	239	6.32e-172	471.0	A0A0E1M219	PHI:9601	RstA	562	nan	Escherichia coli	serotype O157:H7	infection	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Two-component response regulator	reduced virulence	Gene deletion: full; gene complementation	31695752
C1_00909	ACY88258	89.5	314	0	33	1	314	1	314	1.1500000000000002e-200	550.0	D0ZX10	PHI:3780	sssB	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	self-limiting gastroenteritis; typhoid-like disease (mice)	Rodents	10090	Mus musculus (related: house mouse)	Secreted effector protein	effector (plant avirulence determinant)	Gene mutation; gene complementation	23950998
C1_00913	AUY17561	82.2	118	0	21	4	121	3	120	1.1900000000000001e-57	172.0	A0A1C1TY69	PHI:8966	mdtJ	573	nan	Klebsiella pneumoniae	KPPR1	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Multidrug transporter subunit	reduced virulence	Gene deletion: full	29712730
C1_00914	ACI10803	84.4	109	0	17	1	109	1	109	5.01e-65	190.0	B5XR94	PHI:8967	mdtI	573	nan	Klebsiella pneumoniae	KPPR1	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Multidrug resistance protein	reduced virulence	Gene deletion: full	29712730
C1_00931	AEQ97343	60.6	99	0	39	4	102	7	105	2.37e-38	123.0	G7TB42	PHI:9586	XOC_3249	347	nan	Xanthomonas oryzae	pv. oryzicola strain BLS256	bacterial leaf streak	Monocots	4530	Oryza sativa (related: rice)	Membrane protein	reduced virulence	Gene deletion: full; gene complementation	31581193
C1_00981	AAL23157	98.9	188	0	2	1	188	1	188	2.8699999999999997e-136	377.0	P64036	PHI:6420	EF-P	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Elongation factor	increased virulence (hypervirulence)	Altered gene expression / gene regulation: downregulation	27350030
C1_00986	AAT01052	75.8	380	1	89	1	377	2	381	6.13e-217	597.0	Q6PT92	PHI:6133	blaCMY-2	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain SL1344	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Beta-lactamase	reduced virulence	Functional test in host: transient expression	26862033
C1_00990	ACR67633	85.0	602	1	87	1	602	1	599	0.0	1042.0	C5BDL7	PHI:2960	frdA	67780	nan	Edwardsiella ictaluri	93-146	enteric septicemia	Bony fishes	7998	Ictalurus punctatus (related: channel catfish)	Fumarate reductase	reduced virulence	Gene deletion: partial	23762452
C1_00996	AE004908_2	67.4	178	0	58	4	181	3	180	2.74e-87	252.0	P57665	PHI:6274	Orn	287	nan	Pseudomonas aeruginosa	PA14	opportunistic infection	Rodents	10090	Mus musculus (related: house mouse)	Oligoribonuclease	reduced virulence	Gene mutation	27296966
C1_01005	CCE30329	40.6	106	1	61	12	117	7	110	6.61e-13	67.4	M1WES1	PHI:8120_PHI:6267	cpipt-log_ipt-log (cpur_04177)	5111	PHI:6266_PHI:8119_nan	Claviceps purpurea	20.1	ergot	Monocots	4550	Secale cereale (related: rye)	cytokinin production_Bifunctional cytokinin de novo synthesis enzyme having isopentenyl transferase activity and cytokinin-specific phosphoribohydrolase activity	loss of pathogenicity_reduced virulence_unaffected pathogenicity	Gene deletion: full_Gene deletion: full; gene complementation	29850931_27074411
C1_01006	HFQ_SALTY	91.2	102	0	9	1	102	1	102	8.88e-49	149.0	P0A1R0	PHI:2687	hfq	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028s	food poisoning	Rodents	10090	Mus musculus (related: house mouse)	Regulators of systemic infection	reduced virulence	Gene deletion: full; gene complementation	19229334
C1_01011	AAL23186	99.5	432	0	2	1	432	1	432	4.93e-320	862.0	P65882	PHI:9416_PHI:2625	purA	28901	PHI:2622_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain NCTC S12023_subsp. enterica serovar Typhimurium strain SL1344	food poisoning_gastroenteritis	Bony fishes_Rodents	7955_10090	Danio rerio (related: zebrafish)_Mus musculus (related: house mouse)	Adenylosuccinate synthetase_Pathogenicity island	loss of pathogenicity_reduced virulence	Gene mutation: characterised_Gene mutation	31428591_23236281
C1_01012	ARF52028	77.3	141	1	30	1	141	1	139	2.59e-72	211.0	H3RHG9	PHI:12252	nsrR	66269	nan	Pantoea stewartii	subsp. stewartii	stewart's wilt; leaf blight (maize)	Monocots	4577	Zea mays (related: maize)	DNA-binding transcriptional regulator	unaffected pathogenicity	Gene deletion: full; gene complementation	35237242
C1_01027	VEG82718	60.3	468	2	172	1	454	1	468	8.72e-196	555.0	A0A448KH61	PHI:123393	ulaA	730	nan	Haemophilus ducreyi	35000HP	chancroid	Primates	9606	Homo sapiens (related: human)	PTS system ascorbate-specific transporter subunits IICB	unaffected pathogenicity	Gene deletion: full	35876728
C1_01029	VEG82717	48.3	151	3	71	3	148	2	150	6.41e-45	143.0	A0A448KH25	PHI:123395	ulaC	730	nan	Haemophilus ducreyi	35000HP	chancroid	Primates	9606	Homo sapiens (related: human)	PTS system enzyme II-A permease	unaffected pathogenicity	Gene deletion: full	35876728
C1_01047	AAA97109	99.8	647	0	1	1	647	1	647	0.0	1292.0	P08331	PHI:7020	cpdB	562	nan	Escherichia coli	APEC-34 O91	colibacillosis	Birds	9031	Gallus gallus (related: chicken)	2′,3′-Cyclic phosphodiesterase	reduced virulence	Gene mutation	28266315
C1_01054	EFE24560	66.3	572	2	189	10	577	7	578	7.5400000000000015e-283	780.0	D4F0Q0	PHI:10714	tamA	636	nan	Edwardsiella tarda	TX01	edwardsiellosis	Bony fishes	244447	Cynoglossus semilaevis (related: tongue sole)	Autotransporter assembly factor	reduced virulence	Gene deletion: full; gene complementation	32793174
C1_01055	EFE24562	62.9	614	1	227	646	1259	13	625	1.8999999999999998e-270	776.0	D4F0Q2	PHI:10715	tamB	636	nan	Edwardsiella tarda	TX01	edwardsiellosis	Bony fishes	244447	Cynoglossus semilaevis (related: tongue sole)	Autotransporter assembly complex proetin	reduced virulence	Gene deletion: full; gene complementation	32793174
C1_01076	CAH21648	52.0	870	5	393	50	896	29	896	8.77e-313	882.0	Q669S4	PHI:7573	MgtB	633	nan	Yersinia pseudotuberculosis	IP32953	zoonotic infection	Moths	7137	Galleria mellonella (related: greater wax moth)	Magnesium ion transporter	reduced virulence	Gene deletion: full; gene complementation	25234474
C1_01085	abd21287	59.0	332	2	134	1	332	1	330	1.96e-136	389.0	A0A0H2XHH2	PHI:2634	argF	1280	nan	Staphylococcus aureus	USA300 JE2	community-acquired infection; nosocomial infection	Rodents	10090	Mus musculus (related: house mouse)	Ornithine carbamoyltransferase	unaffected pathogenicity	Gene disruption	23209408
C1_01109	SEN1998	43.4	53	0	30	25	77	12	64	1.28e-10	50.8	A0A6C7HRI3	PHI:9805	rdf	28901	PHI:9804	Salmonella enterica	subsp. enterica serovar Dublin strain PT4	gastroenteritis	Rodents	10090	Mus musculus (related: house mouse)	Recombination Directionality Factor	reduced virulence	Gene deletion: full	31800631
C1_01122	ABF06196	95.1	182	0	9	1	182	1	182	1.02e-108	306.0	Q0SXL9	PHI:9888	fimA	562	nan	Escherichia coli	JM103	infection	Primates	9606	Homo sapiens (related: human)	Major type 1 subunit fimbrin (Pilin)	unaffected pathogenicity	Gene disruption	29858013
C1_01123	ABW24954	75.5	163	0	40	3	165	16	178	1.1e-93	268.0	B0LF83	PHI:10208	fimI	573	nan	Klebsiella pneumoniae	TOP52	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Pilin (type 1 fimbria component protein)	unaffected pathogenicity	Gene deletion: full	29158434
C1_01125	SQC44282	40.2	694	12	370	40	727	36	690	6.9e-163	493.0	A0A2X3EJX6	PHI:10210	fimD	573	nan	Klebsiella pneumoniae	TOP52	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Type 1 fimbriae anchoring protein 	unaffected pathogenicity	Gene deletion: full	29158434
C1_01127	ABW24958	74.3	167	1	42	1	167	1	166	8.55e-82	237.0	B0LF87	PHI:10212	fimG	573	nan	Klebsiella pneumoniae	TOP52	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Pilin (type 1 fimbria component protein)	unaffected pathogenicity	Gene deletion: full	29158434
C1_01128	CAA29156_AAC77276	99.7	300	0	1	1	300	1	300	9.16e-216	587.0	P08191	PHI:7846_PHI:9788_PHI:7180_PHI:11259_PHI:7204_PHI:2690_PHI:8107	FimH_fimH	562	nan_PHI:7845	Escherichia coli	H10407_F11_LF82_F149H1S2_CP9_RS218_UTI89	ascending pyelonephritis; urinary tract infection_urinary tract infection_pyelonephritis_crohn's disease_urinary tract infection; meningitis_salpingitis_neonatal meningitis	 hares_Rabbits _Birds_Rodents	9031_10090_9986	Gallus gallus (related: chicken)_Oryctolagus cuniculus (related: rabbit)_Mus musculus (related: house mouse)	Type 1 pilus-associated adhesin_Virulence factor_Type 1 pilus-associated mannose-binding adhesin_Type 1 fimbriae_Type 1 pilus_Type 1 fimbrin D-mannose specific adhesin_Adhesion_Adhesin which binds mannose with stereochemical specificity	reduced virulence_unaffected pathogenicity	Gene deletion: full_Gene mutation; gene complementation_Gene mutation: characterised_Gene deletion: full; gene complementation_Gene mutation	29311232_33513212_31767071_23358328_28545489_28808163_28531220
C1_01164	AAL23350	96.6	716	0	24	1	716	1	716	0.0	1378.0	Q8ZJY5	PHI:7575	yjiY	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028	salmonellosis	Nematodes_Rodents	6239_10090	Caenorhabditis elegans (related: roundworm)_Mus musculus (related: house mouse)	Peptide-utilizing carbon starvation protein	reduced virulence_unaffected pathogenicity	Gene deletion: full; gene complementation	26497384
C1_01165	ACY91777	80.5	554	1	107	1	554	1	553	1.24e-245	684.0	A0A0F6BB74	PHI:6981	tsr	28901	PHI:6979; PHI:6980; PHI:6982; PHI:6983_PHI:6979; PHI:6980; PHI:6982; PHI:6983; PHI:6984; PHI:6985_PHI:6979; PHI:6980_PHI:6979; PHI:6980; PHI:6982; PHI:6983; PHI:6984_PHI:6979; PHI:6980; PHI:6982	Salmonella enterica	subsp. enterica serovar Typhimurium strain NCTC 12023	salmonellosis	Primates	9606	Homo sapiens (related: human)	Methyl-accepting chemotaxis protein	reduced virulence	Gene deletion: full	28212413
C1_01208	CAL20379	41.0	105	0	62	2	106	5	109	4.500000000000001e-22	87.8	Q7CHU5	PHI:8505	BfvR (YPO1737)	632	nan	Yersinia pestis	biovar Microtus strain 91001	pneumonic plague	Nematodes_Rodents	6239_10090	Caenorhabditis elegans (related: roundworm)_Mus musculus (related: house mouse)	AraC-family transcriptional regulator	reduced virulence_increased virulence (hypervirulence)	Gene deletion: full; gene complementation	30333962
C1_01210	AAL23403	84.3	229	0	36	1	229	1	229	3.66e-141	392.0	Q8ZJU6	PHI:11268	creB	28901	PHI:11267_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028s	infection	Rodents	10090	Mus musculus (related: house mouse)	Response regulator in two-component regulatory system	reduced virulence	Gene deletion: full; gene complementation	33563986
C1_01213	AAA97297	100.0	238	0	0	1	238	1	238	3.67e-175	479.0	P0A9Q1	PHI:6532	arcA	562	nan	Escherichia coli	XM	meningitis	Birds	8839	Anas platyrhynchos (related: mallard)	Aerobic respiration control protein	reduced virulence	Gene mutation; gene complementation	26099584
C1_01222	ACI10823	66.2	438	1	147	1	437	1	438	7.47e-212	589.0	B5Y383	PHI:3448	pgaC	573	nan	Klebsiella pneumoniae	CG43	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Production of poly-b-linkedN-acetylglucosamine	reduced virulence	Gene mutation: characterised; gene complementation	25450884
C1_01226	AAC74104	98.8	423	0	5	1	423	1	423	2.02e-313	844.0	P31545	PHI:10992	efeB	562	PHI:10991	Escherichia coli	PCN033	infection	Rodents	10090	Mus musculus (related: house mouse)	Deferrochelatase/peroxidase	unaffected pathogenicity	Gene deletion: full	32962530
C1_01227	AAC74103	99.5	375	0	2	1	375	1	375	9.43e-265	717.0	P0AB24	PHI:10991	efeO	562	PHI:10992	Escherichia coli	PCN033	infection	Rodents	10090	Mus musculus (related: house mouse)	Iron uptake system component 	unaffected pathogenicity	Gene deletion: full	32962530
C1_01230	AE004513_3	48.6	1042	11	492	95	1116	24	1041	1.97e-310	897.0	Q9I5F6	PHI:7999	putA	287	nan	Pseudomonas aeruginosa	PAK	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Bifunctional enzyme which converts proline to glutamate	reduced virulence	Gene deletion: full; gene complementation	29632523
C1_01231	CCP46023	40.7	54	0	32	19	72	40	93	4.9e-06	44.3	O05858	PHI:10876	fasR	1773	nan	Mycobacterium tuberculosis	H37Rv	tuberculosis	Rodents_Primates	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Probable transcriptional regulatory protein	reduced virulence	Gene deletion: full; gene complementation	33193236
C1_01239	AE004642_1	80.0	30	0	6	1	30	1	30	9.83e-10	47.0	Q9I1W9	PHI:10946	PA2146	287	nan	Pseudomonas aeruginosa	PAO1	nosocomial infection	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Conserved hypothetical protein	increased virulence (hypervirulence)	Gene deletion: full; gene complementation	33134189
C1_01240	CAJ11026	57.0	200	3	83	1	198	1	199	3.46e-68	205.0	Q2YQ23	PHI:9134	bab1_1070	235	nan	Brucella abortus	2308	brucellosis	Rodents	10090	Mus musculus (related: house mouse)	NADPH dehydrogenase	unaffected pathogenicity	Gene disruption; gene complementation	29632093
C1_01245	EED46951	44.4	63	1	34	5	67	8	69	2.82e-06	47.0	B8NSQ3	PHI:9939	dnjA (AFLA_050040 )	5059	nan	Aspergillus flavus	NRRL 3357	infection	monocots	4577	Zea mays (related: maize)	J domain-containing protein	reduced virulence	Gene deletion: full; gene complementation	32060628
C1_01272	AAC74057	99.7	372	0	1	1	372	1	372	7.68e-283	763.0	P69739	PHI:11000	hyaA	562	nan	Escherichia coli	PCN033	infection	Rodents	10090	Mus musculus (related: house mouse)	Hydrogenase-1 small chain	unaffected pathogenicity	Gene deletion: full	32962530
C1_01287	AAN42586	98.0	350	1	5	1	350	1	348	1.01e-255	692.0	A0A2S4N3N0	PHI:9891	OmpA	623	PHI:9889_PHI:9892_nan	Shigella flexneri	serotype 2a strain 301	shigellosis	Primates	9606	Homo sapiens (related: human)	Outer membrane protein A	reduced virulence	Gene disruption	29858013
C1_01289	ABN74970	42.1	430	5	240	115	541	73	496	1.37e-93	296.0	A3N3I4	PHI:5467	LonC	715	nan	Actinobacillus pleuropneumoniae	LD20	lung infection	Rodents	10090	Mus musculus (related: house mouse)	Lon proteases	unaffected pathogenicity	Gene mutation	26796296
C1_01291	CBA20332	78.2	55	0	12	1	55	1	55	1.82e-27	91.7	D4I0C5	PHI:3676_PHI:3682	rmf3	552	nan	Erwinia amylovora	Ea1189	fire blight	Eudicots	3750_23211	Malus domestica (related: apple)_Pyrus communis (related: pear)	nan	unaffected pathogenicity	Gene mutation; gene complementation	23937726
C1_01315	AAA24244	100.0	362	0	0	1	362	1	362	1.07e-268	726.0	P02931	PHI:7023	ompF	562	nan	Escherichia coli	TW-XM	meningitis	Birds_Rodents	8839_10090	Anas platyrhynchos (related: mallard)_Mus musculus (related: house mouse)	Outer membrane porin	reduced virulence	Gene deletion: full; gene complementation	28315387
C1_01316	EGZ30267	41.1	399	3	229	4	396	26	424	2.22e-105	316.0	G4YQK3	PHI:6261	PsAAT3	67593	nan	Phytophthora sojae	race 2 strain P6497	stem rot (soybean); root rot (soybean)	Eudicots	3847	Glycine max (related: soybean)	Aspartate aminotransferase	reduced virulence	Altered gene expression / gene regulation: silencing	27020161
C1_01318	AAC74012	100.0	182	0	0	1	182	1	182	1.01e-133	370.0	P0AB06	PHI:11001	ycbK	562	nan	Escherichia coli	PCN033	infection	Rodents	10090	Mus musculus (related: house mouse)	Peptidoglycan LD-endopeptidase	unaffected pathogenicity	Gene deletion: full	32962530
C1_01330	AEQ13038	48.1	239	1	123	341	579	343	580	8.29e-63	216.0	A0A0E0V727	PHI:6913	ybtQ	562	PHI:6911	Escherichia coli	UTI89	urinary tract infection	Rodents	10090	Mus musculus (related: house mouse)	ATP Binding Cassette Protein	reduced virulence	Gene mutation	26883590
C1_01332	IHFB_SALTY	98.9	94	0	1	1	94	1	94	2.39e-65	190.0	P64394	PHI:2673	himD	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028s	food poisoning	Rodents	10090	Mus musculus (related: house mouse)	Regulators of systemic infection	reduced virulence	Gene deletion: full; gene complementation	19229334
C1_01333	FGSG_05002	41.6	77	3	37	196	264	229	305	1.82e-08	55.8	I1RM25	PHI:1579	GzOB019	5518	nan	Fusarium graminearum	GZ3639	fusarium ear blight	Monocots	4564	Triticum (related: wheat)	transcription factor	unaffected pathogenicity	Gene deletion	22028654
C1_01336	CAD05378	89.7	427	0	44	1	427	1	427	1.32e-279	759.0	P19786	PHI:9459	aroA	28901	nan	Salmonella enterica	subsp. enterica serovar Typhi strain Ty2	salmonellosis	Rodents_Primates	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	3-Phosphoshikimate 1-carboxyvinyltransferase	reduced virulence	Gene deletion: full	31447308
C1_01341	MYN69560	44.3	768	12	391	8	756	15	764	1.6999999999999999e-205	598.0	A0A6L8MWN2	PHI:123242	PFL (B9H01_RS01125)	1307	nan	Streptococcus suis	SC19	meningitis, endocarditis; sepsis	Moths	7137	Galleria mellonella (related: greater wax moth)	Formate C-acetyltransferase	reduced virulence	Gene mutation	35630313
C1_01350	no data found	73.3	803	3	211	13	814	6	806	0.0	1238.0	P45004	PHI:11664	dmsA	727	nan	Haemophilus influenzae	Hi2019	haemophilus influenzae disease	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Putative dimethylsulfoxide (DMSO) reductase, catalytic subunit	reduced virulence	Gene deletion: full; gene complementation	34367088
C1_01352	SAS94147	95.7	447	0	19	1	447	1	447	4.61e-313	845.0	A0A164J6A6	PHI:6447	rarA	573	PHI:6448; PHI:6449; PHI:6450	Klebsiella pneumoniae	NCTC 9633	pneumonia	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	Holliday junction DNA helicase	reduced virulence	Gene deletion: full	25193085
C1_01355	CBJ89611	97.6	164	0	4	1	164	1	164	5.76e-113	316.0	D3VBH2	PHI:6497_PHI:7128	lrp	628	nan	Xenorhabdus nematophila	ATCC 19061	nan	Moths_Flies	7227_7130	Manduca sexta (related: tobacco hornworm)_Drosophila melanogaster (related: fruit fly)	Global Transcription Factor_Transcription factor	reduced virulence_increased virulence (hypervirulence)	Altered gene expression / gene regulation: downregulation_Altered gene expression / gene regulation: overexpression_Gene disruption_Gene mutation	26170407_28411220
C1_01356	EJP70691	47.7	323	6	151	6	317	2	317	7.509999999999998e-90	270.0	J5K974	PHI:6470	Trr1	176275	nan	Beauveria bassiana	ARSEF 2860	white muscardine	Moths	7137	Galleria mellonella (related: greater wax moth)	Thioredoxin reductase	unaffected pathogenicity	Gene mutation; gene complementation	27344592
C1_01371	ADM98239	90.2	757	1	73	1	757	1	756	0.0	1323.0	E0SMW9	PHI:8569	clpA (Dda3937_02363)	204038	PHI:8568	Dickeya dadantii	3937	soft rot	Eudicots	13427	Cichorium intybus (related: chicory)	ATP-dependent Clp protease ATP-binding subunit	reduced virulence	Gene deletion: full	30267562
C1_01372	ADM98238	77.4	106	0	24	1	106	1	106	5.690000000000001e-56	167.0	E0SMW8	PHI:8568	clpS	204038	PHI:8569	Dickeya dadantii	3937	soft rot	Eudicots	13427	Cichorium intybus (related: chicory)	ATP-dependent Clp protease adapter protein	reduced virulence	Gene deletion: full	30267562
C1_01373	ACD59665	63.2	68	0	25	1	68	1	68	3.37e-28	94.7	A0A0K0GLJ4	PHI:8639	CspD ( WP_003488188.1)	347	nan	Xanthomonas oryzae	pv. oryzae strain PXO99	bacterial leaf blight	Monocots	4530	Oryza sativa (related: rice)	Uncharacterized protein	unaffected pathogenicity	Gene deletion: full; gene complementation	30372574
C1_01374	AAL19878	83.2	648	0	109	1	648	1	648	0.0	1026.0	Q8ZQE4	PHI:3928	MacB	28901	PHI:3929	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028	food poisoning; enteritis	Rodents	10090	Mus musculus (related: house mouse)	ABC-Type Efflux Pump	reduced virulence	Gene deletion	24169575
C1_01375	ADX1663	83.9	367	0	59	3	369	4	370	1.5000000000000002e-211	582.0	E8XCP9	PHI:3929	MacA	28901	PHI:3928	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028	food poisoning; enteritis	Rodents	10090	Mus musculus (related: house mouse)	ABC-Type Efflux Pump	reduced virulence	Gene deletion	24169575
C1_01376	ABJ00255	99.7	328	0	1	1	328	1	328	1.9e-239	649.0	A0A0H2YXK5	PHI:9384	ybjX	562	PHI:9385	Escherichia coli	AE17	avian colibacillosis	Birds	9031	Gallus gallus (related: chicken)	Conserved hypothetical protein	reduced virulence_unaffected pathogenicity	Gene mutation; gene complementation	31326704
C1_01380	AAC73960	99.6	550	0	2	1	550	1	550	0.0	1109.0	P75825	PHI:12049	hcp	562	nan	Escherichia coli	APEC O18	colibacillosis	Eukaryotes	44689	Dictyostelium discoideum (related: amoeba)	Hydroxylamine reductase	reduced virulence_unaffected pathogenicity	Gene deletion: full; gene complementation	35003930
C1_01424	AAC66721	49.3	286	3	139	311	590	6	291	1.71e-81	258.0	H7C7L2	PHI:7821	oppF (bb0335)	139	PHI:7820	Borreliella burgdorferi	B31 5A18 NP1	lyme disease	Rodents	10090	Mus musculus (related: house mouse)	Oligopepeptide (Opp) transporter that drives transport by hydrolyzing ATP	reduced virulence	Gene mutation; chemical complementation	29259089
C1_01446	AAO70494	46.9	162	0	86	46	207	24	185	6.4899999999999996e-46	149.0	Q8Z3Y9	PHI:8849	STY3178 (YfdX)	28901	nan	Salmonella enterica	subsp. enterica serovar Typhi strain UK-1	salmonellosis	Moths	7137	Galleria mellonella (related: greater wax moth)	Conserved hypothetical protein	unaffected pathogenicity_increased virulence (hypervirulence)	Gene deletion: full; gene complementation	30692978
C1_01478	ABO11237	51.7	671	4	315	3	669	5	670	2.6e-232	659.0	A3M2U3	PHI:7809	adeN	470	nan	Acinetobacter baumannii	ATCC 17978	nosocomial infection	Moths	7137	Galleria mellonella (related: greater wax moth)	TetR type regulator	increased virulence (hypervirulence)	Gene disruption; gene complementation	28436748
C1_01481	EAL93059	42.0	312	6	167	12	314	21	327	1.24e-64	211.0	Q4X256	PHI:6556	mecA	746128	PHI:6557_nan	Aspergillus fumigatus	ATCC 46645	invasive pulmonary aspergillosis	Rodents	10090	Mus musculus (related: house mouse)	Cystathionine-beta -synthase	reduced virulence_unaffected pathogenicity	Gene deletion: full	26787716
C1_01482	CBA21825	95.3	85	0	4	1	85	1	85	3.91e-51	153.0	D4HXP5	PHI:9311	ptsH	552	nan	Erwinia amylovora	HKN06P1	fire blight	Eudicots	3750	Malus domestica (related: apple)	Phosphocarrier protein HPr	reduced virulence	Gene mutation	31152019
C1_01483	ACI80411	100.0	575	0	0	1	575	1	575	0.0	1088.0	C3T127	PHI:9499	ptsI	562	nan	Escherichia coli	serotype O2 strain DE17	avian colibacillosis	Birds	8839	Anas platyrhynchos (related: mallard)	Phosphoenolpyruvate-protein phosphotransferase	reduced virulence	Gene deletion: full; gene complementation	29111323
C1_01488	ACO02289	43.6	211	2	112	1	211	1	204	1.47e-42	147.0	C0RL06	PHI:11542	B0446	29459	nan	Brucella melitensis	M28	brucellosis	Rodents	10090	Mus musculus (related: house mouse)	ABC transporter substrate-binding protein	unaffected pathogenicity	Gene deletion: full; gene complementation	32778612
C1_01494	ABD22914	46.4	293	0	157	3	295	2	294	1.41e-86	259.0	Q2FK71	PHI:7350	murQ	1280	nan	Staphylococcus aureus	JE2	skin infection; food poisoning; respiratory disease	Bony fishes	7955	Danio rerio (related: zebrafish)	N-acetylmuramic acid-6-phosphate etherase	unaffected pathogenicity	Gene mutation	28808156
C1_01501	AAC75488	99.7	289	0	1	1	289	1	289	6.84e-201	548.0	P36548	PHI:10979	amiA	562	PHI:10980_nan	Escherichia coli	PCN033	infection	Even-toed ungulates_Rodents	9823_10036_10090	Mesocricetus auratus (related: golden hamster)_Sus scrofa (related: pig)_Mus musculus (related: house mouse)	N-acetylmuramoyl-L-alanine amidase	reduced virulence	Gene deletion: full	32962530
C1_01503	CBG89139	92.0	349	0	28	1	349	1	349	5.919999999999999e-244	662.0	D2TT81	PHI:11464	eutR	67825	nan	Citrobacter rodentium	DBS100	colitis	Rodents	10090	Mus musculus (related: house mouse)	Ethanolamine-sensing transcription factor	reduced virulence	Gene deletion: full; gene complementation	32631916
C1_01527	QUZ94265	94.3	1037	0	59	1	1037	1	1037	0.0	1867.0	A0A8E5JM30	PHI:12047	acrD	28901	nan	Salmonella enterica	serovar Enteritidis strain SJTUF10978	salmonellosis	Primates	9606	Homo sapiens (related: human)	Resistance-nodulation-cell division (RND) transporter	reduced virulence	Gene deletion: full	35010216
C1_01555	AAM41222	47.4	352	6	141	351	664	142	487	3.8200000000000003e-85	275.0	Q8P9D2	PHI:12169	fleQ	339	PHI:12167; PHI:12168; PHI:12170_PHI:12168_PHI:12167_PHI:12168; PHI:12170_nan_PHI:12170_PHI:12167; PHI:12170_PHI:12167; PHI:12168_PHI:12171	Xanthomonas campestris	pv. campestris strain 8004 (Δlac8)	black rot	Eudicots	3712	Brassica oleracea (no common name found)	Transcriptional regulator	loss of pathogenicity_reduced virulence_unaffected pathogenicity_increased virulence (hypervirulence)	Gene deletion: full; gene complementation	34837306
C1_01564	AAA83899	99.1	212	0	2	1	212	1	212	1.5e-152	420.0	P08179	PHI:8652	purN	562	nan_PHI:8653	Escherichia coli	UTI89	infection	Rodents_Primates	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Phosphoribosylglycinamide formyltransferase	reduced virulence_unaffected pathogenicity	Gene deletion: full; gene complementation	30377949
C1_01565	ACI80066	100.0	688	0	0	1	688	1	688	0.0	1362.0	C3T032	PHI:11759	ppk1	562	nan	Escherichia coli	EDL933w	colitis	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Polyphosphate kinase 1	reduced virulence	Gene deletion: full; gene complementation	34777317
C1_01572	AFR98073	49.7	547	8	245	2	524	3	543	6.98e-181	518.0	J9VUY6	PHI:6871	gua1	5207	nan	Cryptococcus neoformans	H99	fungal meningitis	Nematodes_Rodents	6239_10090	Caenorhabditis elegans (related: roundworm)_Mus musculus (related: house mouse)	GMP synthase	loss of pathogenicity	Gene deletion: full; gene complementation	28062578
C1_01573	CBA21987	93.2	488	0	33	1	488	1	488	1.05e-316	858.0	D4HYB2	PHI:9306	guaB	552	nan	Erwinia amylovora	HKN06P1	fire blight	Eudicots	3750	Malus domestica (related: apple)	Inosine-5'-monophosphate dehydrogenase	reduced virulence	Gene mutation	31152019
C1_01576	ABP90420	41.0	134	2	74	203	336	224	352	5.03e-21	94.0	A4VWD1	PHI:11090_PHI:9270	mnmE	1307	PHI:11091_nan	Streptococcus suis	SC19	meningitis; septicemia; streptococcal toxic shock syndrome	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Central tRNA-modifying GTPase_tRNA modification GTPase	reduced virulence	Gene deletion: full; gene complementation	31179247_33425782
C1_01583	AAY49259	63.1	141	0	52	1	141	1	141	3.02e-61	183.0	Q4UUL4	PHI:3945	XC_2203	339	nan	Xanthomonas campestris	pv. campestris strain 8004	black rot	Eudicots	3726	Raphanus sativus (related: radish)	Nucleotide diphosphate kinase	reduced virulence	Gene mutation	23819805
C1_01586	AAO68047	80.4	280	0	55	1	280	1	280	2.63e-171	473.0	Q8Z4N6	PHI:609_PHI:616	sseA	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain SL1344	gastroenteritis	Rodents	10090	Mus musculus (related: house mouse)	Type III secretion_nan	reduced virulence	Other evidence	16113260
C1_01587	ACY89541	90.7	258	0	24	1	258	4	261	7.46e-172	473.0	D0ZRW0	PHI:3761	sseB	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	self-limiting gastroenteritis; typhoid-like disease (mice)	Rodents	10090	Mus musculus (related: house mouse)	Secreted effector protein	effector (plant avirulence determinant)	Gene mutation; gene complementation	23950998
C1_01594	APQ81541	98.4	128	0	2	1	128	1	128	3.2600000000000003e-88	250.0	A0A0L9JQ40	PHI:6892	iscU	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain 12023	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Fe-S cluster sensor	reduced virulence	Gene mutation	27704705
C1_01596	AAL21438	97.0	164	1	3	1	162	1	164	3.44e-109	306.0	Q7CQ10	PHI:6895	iscR	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain 12023	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Fe-S cluster sensor	reduced virulence	Gene mutation	27704705
C1_01598	ABJ13079	55.0	271	2	118	1	267	1	271	7.55e-97	283.0	Q02RX2	PHI:3915	SuhB	287	nan	Pseudomonas aeruginosa	PAK	nosocomial infection	Rodents	10090	Mus musculus (related: house mouse)	an essential gene for the T3SS gene expression	loss of pathogenicity	Gene mutation	24169572
C1_01616	ACR70340	87.5	417	0	52	1	417	1	417	1.7700000000000002e-272	740.0	C5BEV2	PHI:2962	glyA	67780	nan	Edwardsiella ictaluri	93-146	enteric septicemia	Bony fishes	7998	Ictalurus punctatus (related: channel catfish)	Serine h ydroxymethyltra nsferase	reduced virulence	Gene deletion: partial	23762452
C1_01617	ACY89566	91.7	396	0	33	1	396	1	396	2.55e-275	746.0	A0A0F6B4X5	PHI:123380	hmpA	28901	PHI:123379_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028s	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	nitric oxide dioxygenase	reduced virulence	Gene deletion: full	35806223
C1_01620	AE005485_7	98.3	237	0	4	1	237	1	237	8.62e-169	463.0	P0AD45	PHI:9122	qseG	562	nan	Escherichia coli	86-24	urinary tract infection	 hares_Rabbits 	9986	Oryctolagus cuniculus (related: rabbit)	Outer membrane lipoprotein, quorum sensing regulator	reduced virulence	Gene mutation; gene complementation	29358334
C1_01621	AE005486_1	99.5	439	0	2	22	460	37	475	1.76e-309	838.0	Q8XA47	PHI:12149	qseE	562	nan	Escherichia coli	serotype O157:H7 strain 85-170	infection	Moths_Primates	7137_9606	Homo sapiens (related: human)_Galleria mellonella (related: greater wax moth)	Two-component regulatory system protein	reduced virulence_unaffected pathogenicity	Gene deletion: full	35137015
C1_01622	CBA22070	84.3	1295	1	202	1	1295	1	1294	0.0	2205.0	D4HYF4	PHI:9320	purL	552	nan	Erwinia amylovora	HKN06P1	fire blight	Eudicots	3750	Malus domestica (related: apple)	Phosphoribosylformylglycinamidine synthase	reduced virulence	Gene mutation	31152019
C1_01631	AAK33487	44.0	291	4	159	9	297	5	293	1.73e-77	236.0	P0C0B9	PHI:11438	bglB	1314	PHI:11439_nan	Streptococcus pyogenes	5448	infection	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Putative phospho--glucosidase	reduced virulence_increased virulence (hypervirulence)	Gene deletion: full; gene complementation	32719156
C1_01632	AAA92440	97.3	226	0	6	1	226	1	226	1.67e-156	431.0	Q56056	PHI:3724	RNase III	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain SL1344	food poisoning	Moths	7137	Galleria mellonella (related: greater wax moth)	endoribonucleases	reduced virulence	Gene mutation; gene complementation	23913419
C1_01638	AAC45314	100.0	191	0	0	1	191	1	191	2.01e-133	370.0	P0AGB6	PHI:123198	rpoE	562	nan	Escherichia coli	RS218	neonatal meningitis	Rodents	10090	Mus musculus (related: house mouse)	Extracytoplasmic function sigma factor	reduced virulence	Gene deletion: full; gene complementation	35630325
C1_01639	AAO89667	53.1	531	7	225	10	531	5	520	6.06e-184	526.0	Q83F48	PHI:8507	nadB	777	nan	Coxiella burnetii	Nine Mile phase II	q fever	Primates	9606	Homo sapiens (related: human)	Putative L-aspartate oxidase	reduced virulence	Gene mutation: characterised; gene complementation_Gene mutation; gene complementation	30315113
C1_01642	CBG86980	79.7	231	0	47	3	233	2	232	9.24e-140	389.0	D2TI83	PHI:8514	nlpE	67825	PHI:8515_nan	Citrobacter rodentium	DBS100	colitis	Rodents	10090	Mus musculus (related: house mouse)	Outer-membrane lipoprotein	unaffected pathogenicity	Gene deletion: full_Gene deletion: full; gene complementation	30280092
C1_01654	AF142597_1	52.7	203	0	96	60	262	56	258	8.4e-69	211.0	Q9X6P4	PHI:3785	PA3644	287	nan	Pseudomonas aeruginosa	PAO1	infection	Beetles	7067	Tenebrio molitor (related: yellow mealworm)	acyltransferases	reduced virulence	Altered gene expression / gene regulation: overexpression	23848169
C1_01655	EPT32247	46.9	145	2	74	2	144	82	225	5.37e-38	127.0	A0A125YY88	PHI:11972	fabZ (TGME49_321570)	5811	 	Toxoplasma gondii	RH_Prugniaud	toxoplasmosis	Rodents	10090	Mus musculus (related: house mouse)	Beta-hydroxyacyl-acyl carrier protein dehydratase	reduced virulence	Gene deletion: full	34531837
C1_01656	AE004784_7	46.3	335	0	180	3	337	6	340	3.08e-77	239.0	Q9HXY6	PHI:3784	PA3646	287	nan	Pseudomonas aeruginosa	PAO1	infection	Beetles	7067	Tenebrio molitor (related: yellow mealworm)	acyltransferases	reduced virulence	Altered gene expression / gene regulation: overexpression	23848169
C1_01659	ACD59567	41.1	443	10	240	12	446	12	441	1.42e-97	298.0	B2SR06	PHI:3895	PXO_01122	347	nan	Xanthomonas oryzae	pv. oryzae strain PXO99A	bacterial leaf blight	Monocots	4530	Oryza sativa (related: rice)	PDZ domain-containing proteases	reduced virulence	Gene disruption; gene complementation	24200074
C1_01668	CBG86951	89.8	264	0	27	1	264	1	264	4.39e-180	494.0	D2TI55	PHI:9334	map	67825	nan	Citrobacter rodentium	DBS100	colitis	Rodents	10090	Mus musculus (related: house mouse)	Effector protein	effector (plant avirulence determinant)	Gene mutation	31251784
C1_01673	CBG86945	94.3	474	1	24	1	474	1	471	5.1e-307	832.0	D2TI49	PHI:8690	degP (ROD_01651)	67825	PHI:8688; PHI:8689_nan	Citrobacter rodentium	DBS100	colitis	Rodents	10090	Mus musculus (related: house mouse)	Periplasmic serine endoprotease DegP-like	loss of pathogenicity_unaffected pathogenicity	Altered gene expression / gene regulation_Gene deletion: full; gene complementation	30536519
C1_01680	AAY47966	63.6	423	1	153	2	424	4	425	2.27e-194	543.0	Q4UYA7	PHI:3950	XC_0892	339	nan	Xanthomonas campestris	pv. campestris strain 8004	black rot	Eudicots	3726	Raphanus sativus (related: radish)	Glutamate-1-semialdehyde aminotransferase	reduced virulence	Gene mutation	23819805
C1_01682	AAC73263	100.0	296	0	0	1	296	1	296	1.5299999999999998e-221	601.0	P07822	PHI:10989	fhuD	562	nan	Escherichia coli	PCN033	infection	Rodents	10090	Mus musculus (related: house mouse)	Iron(III) hydroxamate ABC transporter periplasmic binding protein	unaffected pathogenicity	Gene deletion: full	32962530
C1_01689	AAD01437	98.7	151	0	2	1	151	1	151	2.61e-105	295.0	P0A1G5	PHI:6508	DksA	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Response Regulator	reduced virulence	Gene mutation; gene complementation	26553464
C1_01699	AAC73246	64.2	424	4	140	1	424	1	412	2.26e-187	525.0	P31058	PHI:6567	yadC	562	nan	Escherichia coli	APEC strain SCI-07	colibacillosis	Birds	9031	Gallus gallus (related: chicken)	Fimbrial-like adhesin protein	reduced virulence	Gene deletion: full; gene complementation	26502907
C1_01703	AAY49516	51.2	123	0	60	4	126	4	126	5.82e-42	133.0	Q4UTV7	PHI:3968	XC_2466	339	nan	Xanthomonas campestris	pv. campestris strain 8004	black rot	Eudicots	3726	Raphanus sativus (related: radish)	Aspartate alpha-decarboxylase	reduced virulence	Gene mutation	23819805
C1_01711	AAC73234	99.2	516	0	4	1	516	1	516	0.0	1022.0	P36649	PHI:10985	cueO	562	nan	Escherichia coli	PCN033	infection	Rodents	10090	Mus musculus (related: house mouse)	Blue copper oxidase	reduced virulence	Gene deletion: full	32962530
C1_01713	AAC73232	100.0	288	0	0	1	288	1	288	4.5699999999999996e-219	594.0	P09158	PHI:9153	speE	562	PHI:9152_PHI:9150	Escherichia coli	APEC serotype O83:H4 ST117	colibacillosis	Birds	9031	Gallus gallus (related: chicken)	Polyamine aminopropyltransferase	unaffected pathogenicity	Gene mutation	29519523
C1_01714	AAC73231	100.0	264	0	0	1	264	1	264	9.08e-198	538.0	P0A7F6	PHI:9152	speD	562	PHI:9153_PHI:9151	Escherichia coli	APEC serotype O83:H4 ST117	colibacillosis	Birds	9031	Gallus gallus (related: chicken)	S-adenosylmethionine decarboxylase proenzyme	unaffected pathogenicity	Gene mutation	29519523
C1_01718	AAU27584	62.7	475	2	175	1	474	6	479	6.01e-212	592.0	Q5ZVD8	PHI:6520	LpdA	446	nan	Legionella pneumophila	130b	legionnaires' disease	Rodents	10090	Mus musculus (related: house mouse)	Effector (plant avirulence determinant)	effector (plant avirulence determinant)	Gene deletion: full	26216420
C1_01719	AAC45354	54.1	549	7	220	108	630	5	547	4.76e-162	474.0	Q59638	PHI:12232	aceF	287	PHI:12233_nan	Pseudomonas aeruginosa	PA14	nosocomial infection	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Dihydrolipoamide acetyltransferase	reduced virulence_unaffected pathogenicity	Gene deletion: full; gene complementation	35336241
C1_01721	CAH19952	86.2	253	0	35	1	253	1	253	4.12e-148	412.0	Q66EI1	PHI:3135	pdhR	633	nan	Yersinia pseudotuberculosis	YPIII	gut-associated disease; diarrhea; enteritis; colitis	Rodents	10090	Mus musculus (related: house mouse)	Part of the pyruvate - tricarboxylic acid cycle node	reduced virulence	Gene disruption	25164818
C1_01726	AJF38890	61.1	144	1	55	1	144	1	143	4.44e-59	178.0	A0A0U1YU94	PHI:6362	pilA	553	nan	Pantoea ananatis	LMG 20103	nan	Monocots	4679	Allium cepa (related: onion)	Twitching motility	reduced virulence	Gene mutation; gene complementation	27226224
C1_01734	AKJ44529	58.9	913	8	356	1	900	1	907	0.0	1019.0	A0A059ZR97	PHI:5240	secA	470	nan	Acinetobacter baumannii	ATCC 19606	nosocomial infection	Moths	7137	Galleria mellonella (related: greater wax moth)	Iron utilization	reduced virulence	Gene mutation; gene complementation	25605767
C1_01736	ACC58837	51.2	297	1	144	1	297	1	296	1.36e-111	323.0	B2I1I9	PHI:10612	lpxC	470	nan	Acinetobacter baumannii	ATCC 19606	nosocomial infection	Primates	9606	Homo sapiens (related: human)	UDP-3-O-acyl-N-acetylglucosamine deacetylase	reduced virulence	Gene mutation; gene complementation	32373082
C1_01744	AE004856_13	50.3	443	8	199	10	437	11	447	9.36e-124	365.0	Q9HVZ9	PHI:7631	murD	287	nan	Pseudomonas aeruginosa	PAO1	infection	Eudicots_Rodents	4236_10090	Lactuca sativa (related: garden lettuce)_Mus musculus (related: house mouse)	UDP-N-acetylmuramoylalanine--D-glutamate ligase	loss of pathogenicity_reduced virulence	Gene deletion: full	29045498
C1_01746	AAG07804	47.2	449	8	224	6	446	7	450	8.08e-112	335.0	Q9HVZ7	PHI:7632	murF	287	nan	Pseudomonas aeruginosa	PAO1	infection	Eudicots_Rodents	4236_10090	Lactuca sativa (related: garden lettuce)_Mus musculus (related: house mouse)	Peptidyl-prolyl cis-trans isomerase	loss of pathogenicity_unaffected pathogenicity	Gene deletion: full	29045498
C1_01750	BAB42274	41.1	314	5	169	5	309	2	308	6.350000000000001e-73	226.0	P60392	PHI:4961	rsmH	1280	nan	Staphylococcus aureus	RN4220	skin infection; food poisoning; respiratory disease	Moths	7091	Bombyx mori (related: domestic silkworm)	Ribosomal RNA small subunit methyltransferase H	reduced virulence	Gene deletion: full; gene complementation	25893373
C1_01752	CRA_SALTY	98.8	334	0	4	1	334	1	334	2.23e-240	652.0	P0A2P8	PHI:2672	fruR	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028s	food poisoning	Rodents	10090	Mus musculus (related: house mouse)	Regulators of systemic infection	reduced virulence	Gene deletion: full; gene complementation	19229334
C1_01753	EHA48246	44.7	94	0	52	2	95	81	174	5.98e-18	77.4	G4NC97	PHI:3976	MoIlv6	318829	nan	Magnaporthe oryzae	Guy11	blast (rice)	Monocots	4530_4513	Oryza sativa (related: rice)_Hordeum vulgare (related: barley)	Acetolactate synthases	loss of pathogenicity	Gene disruption; gene complementation	23782532
C1_01754	AAR29084	41.8	595	14	305	4	568	126	709	8.019999999999999e-136	410.0	Q6SSJ3	PHI:358	ILV2	5207	nan	Cryptococcus neoformans	H99	cryptococcosis	Rodents	10090	Mus musculus (related: house mouse)	Acetolactate synthase	loss of pathogenicity	Gene disruption; gene complementation	15133116
C1_01755	AKO75949	53.6	295	2	134	19	312	20	312	1.55e-102	301.0	A0A0H6RQV7	PHI:7770	leuO	666	PHI:7771; PHI:7772; PHI:7773; PHI:7774; PHI:7775; PHI:7776	Vibrio cholerae	JB58 (Smr ΔlacZ)	cholera	Rodents	10090	Mus musculus (related: house mouse)	Leucine transcriptional activator	reduced virulence	Gene mutation	29304169
C1_01756	ACI08908	92.7	523	0	38	1	523	1	523	0.0	957.0	B5Y1W2	PHI:8962	leuA	573	nan	Klebsiella pneumoniae	KPPR1	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	2-Isopropylmalate synthase	reduced virulence	Gene deletion: full	29712730
C1_01757	ACH50288	94.2	363	0	21	1	363	1	363	1.85e-249	677.0	B5F7U8	PHI:8862	LeuB	28901	PHI:8860; PHI:8861; PHI:8863_PHI:8863	Salmonella enterica	subsp. enterica serovar Agona strain Ag 1	infection	Rodents	10090	Mus musculus (related: house mouse)	3-isopropylmalate dehydrogenase_3-Isopropylmalate dehydrogenase	reduced virulence	Gene mutation	30671294
C1_01758	AIT01851	97.4	466	0	12	1	466	1	466	0.0	903.0	W9BBU8	PHI:8964	leuC	573	nan	Klebsiella pneumoniae	KPPR1	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	3-Isopropylmalate dehydratase large subunit	reduced virulence	Gene deletion: full	29712730
C1_01759	AIT01850	88.1	201	0	24	1	201	1	201	4.29e-133	370.0	W9BQ45	PHI:8965	leuD	573	nan	Klebsiella pneumoniae	KPPR1	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	3-Isopropylmalate dehydratase small subunit	reduced virulence	Gene deletion: full	29712730
C1_01775	BAA34130	100.0	784	0	0	1	784	1	784	0.0	1615.0	P31554	PHI:10312	LptD	562	nan	Escherichia coli	KP7600	urinary tract infection	Moths_Rodents	10090_7091	Bombyx mori (related: domestic silkworm)_Mus musculus (related: house mouse)	LPS-assembly protein	unaffected pathogenicity_increased virulence (hypervirulence)	Gene mutation	32324807
C1_01778	ACT14650	79.8	272	0	55	1	272	1	272	4.05e-155	431.0	C6DEY6	PHI:10573	rsmA	554	nan	Pectobacterium carotovorum	subsp. carotovorum strain PccS1	soft rot	Monocots	69721	Zantedeschia aethiopica (related: arum-lily)	Ribosomal RNA small subunit methyltransferase A	unaffected pathogenicity	Gene deletion: full; gene complementation	32267092
C1_01793	CAE31262	42.1	254	6	138	9	261	15	260	3.07e-55	177.0	A0A0H3LHY6	PHI:10875	HK2 (BB0763)	139	nan	Borreliella burgdorferi	B31 A3	lyme disease	Rodents	10090	Mus musculus (related: house mouse)	Enoyl CoA dehydratase/isomerase	reduced virulence	Altered gene expression / gene regulation: overexpression_Gene mutation	33195322
C1_01798	ADN00101	87.4	380	0	48	1	380	1	380	1.57e-248	677.0	E0SH08	PHI:8577	carA (Dda3937_01390)	204038	nan	Dickeya dadantii	3937	soft rot	Eudicots	13427	Cichorium intybus (related: chicory)	Carbamoyl-phosphate synthase small subunit	reduced virulence	Gene deletion: full	30267562
C1_01812	CAA27969	99.7	299	0	1	1	299	3	301	7.28e-222	602.0	P0A9G2	PHI:3267	nhaR	562	PHI:3266	Escherichia coli	536	infection	Rodents	10090	Mus musculus (related: house mouse)	Transcriptional activator protein	reduced virulence	Gene mutation: characterised; gene complementation	25268639
C1_01813	AAA23448	99.2	388	0	3	1	388	1	388	1.15e-267	726.0	P13738	PHI:3266	nhaA	562	PHI:3267_nan	Escherichia coli	536	infection	Rodents	10090	Mus musculus (related: house mouse)	Antiporter gene	reduced virulence	Gene mutation: characterised; gene complementation	25268639
C1_01815	AE004889_9	62.5	379	2	135	1	374	1	377	3.3e-149	425.0	Q9HV44	PHI:10485	dnaJ	287	nan	Pseudomonas aeruginosa	PAO1	opportunistic infection	Flies	7227	Drosophila melanogaster (related: fruit fly)	Heat shock protein	reduced virulence	Gene mutation; gene complementation	32178243
C1_01819	AAC73121	100.0	188	0	0	1	188	1	188	6.5e-133	368.0	P0AC98	PHI:9230	satP	562	nan	Escherichia coli	FY26	avian colisepticemia	Birds_Rodents	9031_10090	Gallus gallus (related: chicken)_Mus musculus (related: house mouse)	Succinate-acetate/proton symporter 	unaffected pathogenicity	Gene mutation; gene complementation	31046828
C1_01823	STV70203	82.9	257	0	44	1	257	294	550	1.54e-148	424.0	A0A378CFB4	PHI:11408	yaaA	573	nan	Klebsiella pneumoniae	ATCC 43816; MKP203	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Alanine/glycine transport protein	reduced virulence	Gene deletion: full; gene complementation	31988174
C1_01824	AJF38891	60.1	328	1	127	1	324	1	328	3.97e-131	375.0	A0A0U1YU79	PHI:6363	pilT	553	nan	Pantoea ananatis	LMG 20103	nan	Monocots	4679	Allium cepa (related: onion)	Twitching motility	reduced virulence	Gene mutation; gene complementation	27226224
C1_01842	AAC76002	98.9	711	0	8	1	711	1	711	0.0	1435.0	P21169	PHI:9151	speC	562	PHI:9150	Escherichia coli	APEC serotype O83:H4 ST117	colibacillosis	Birds	9031	Gallus gallus (related: chicken)	Constitutive ornithine decarboxylase	reduced virulence_unaffected pathogenicity	Gene mutation	29519523
C1_01853	AAR99586	50.5	390	5	184	114	497	189	575	1.19e-121	366.0	Q6R4Z3	PHI:123089	xpsE	347	PHI:123088_nan	Xanthomonas oryzae	pv. oryzae strain BXO43	blight (rice)	Monocots	4530	Oryza sativa (related: rice)	Type II secretion system protein E	reduced virulence	Gene deletion: full_Gene deletion: full; gene complementation	34704368
C1_01854	CAA47124	49.1	645	10	286	19	647	4	622	4.06e-193	560.0	P31780	PHI:11440	exeD	644	nan	Aeromonas hydrophila	vAh ML09-119	diarrhea; nausea; vomiting	Bony fishes	7998	Ictalurus punctatus (related: channel catfish)	Secretin	reduced virulence	Gene deletion: full; gene complementation	33088835
C1_01857	AAC63504	46.1	267	4	133	4	259	2	268	9.98e-72	220.0	O68839	PHI:702	VcpD	666	nan	Vibrio cholerae	O395	cholera	Rodents	10090	Mus musculus (related: house mouse)	Required for philus assembly and CT secretion	reduced virulence	Gene disruption	9781884
C1_01858	CBJ02741	89.9	1526	5	146	1	1525	1	1519	0.0	2684.0	E3PJ90	PHI:7003	YghJ	562	nan	Escherichia coli	nan	urinary tract infection	Rodents	10090	Mus musculus (related: house mouse)	Secreted metalloprotease and surface associated lipoprotein	unaffected pathogenicity	Functional test in host: direct injection	28212863
C1_01860	CCP44603	57.6	724	4	293	1	716	1	718	6.8e-297	828.0	P9WK17	PHI:7586	Rv1837c (glcB)	1773	nan	Mycobacterium tuberculosis	CDC1551	tuberculosis	Primates	9606	Homo sapiens (related: human)	Malate synthase G	increased virulence (hypervirulence)	Altered gene expression / gene regulation: overexpression	26605666
C1_01888	AAC76032	99.7	328	0	1	1	328	1	328	1.42e-258	697.0	P0AAJ8	PHI:10995	hybA	562	PHI:10996	Escherichia coli	PCN033	infection	Rodents	10090	Mus musculus (related: house mouse)	Hydrogenase-2 operon protein	unaffected pathogenicity	Gene deletion: full	32962530
C1_01889	AAC76033	100.0	372	0	0	1	372	1	372	1.27e-281	759.0	P69741	PHI:10996	hybO	562	PHI:10995	Escherichia coli	PCN033	infection	Rodents	10090	Mus musculus (related: house mouse)	Hydrogenase-2 small chain	unaffected pathogenicity	Gene deletion: full	32962530
C1_01901	EJP63790	42.7	262	4	141	7	261	37	296	1.73e-67	210.0	J4VZT4	PHI:9444	Bbakr1 (XP_008600433.1)	176275	nan	Beauveria bassiana	Bb0062	white muscardine	Moths	7137	Galleria mellonella (related: greater wax moth)	Aldo/keto reductase	unaffected pathogenicity	Altered gene expression / gene regulation: overexpression_Gene disruption; gene complementation	29305969
C1_01906	ABV16661	100.0	470	0	0	1	470	1	470	0.0	957.0	A7ZRQ3	PHI:10978	sufI	562	nan	Escherichia coli	PCN033	infection	Even-toed ungulates_Rodents	9823_10036_10090	Mesocricetus auratus (related: golden hamster)_Sus scrofa (related: pig)_Mus musculus (related: house mouse)	Cell division protein	reduced virulence	Gene deletion: full	32962530
C1_01912	CAD03009	87.6	218	0	27	1	218	1	218	1.41e-140	390.0	P66796	PHI:6882	QseB	28901	nan	Salmonella enterica	subsp. enterica serovar Typhi strain GIFU10007	salmonellosis	Primates	9606	Homo sapiens (related: human)	Two-component system response regulator	increased virulence (hypervirulence)	Gene mutation; gene complementation	28062286
C1_01913	AE005532_4	98.9	449	0	5	1	449	1	449	3.56e-318	858.0	Q8X524	PHI:12147	qseC	562	nan	Escherichia coli	serotype O157:H7 strain 85-170	infection	Moths_Primates	7137_9606	Homo sapiens (related: human)_Galleria mellonella (related: greater wax moth)	Two-component regulatory system protein	reduced virulence_unaffected pathogenicity	Gene deletion: full	35137015
C1_01922	ACN32294	100.0	493	0	0	1	493	3	495	0.0	916.0	C0LTR9	PHI:123409	tolC	562	nan	Escherichia coli	PPECC42	infection	Even-toed ungulates_Rodents	9823_10090	Sus scrofa (related: pig)_Mus musculus (related: house mouse)	tolerant colicin	reduced virulence	Gene deletion: full; gene complementation	36059454
C1_01929	CNQ39570	84.0	94	1	14	1	94	1	93	5.839999999999999e-45	139.0	A0A0U1J4N7	PHI:6697	yqiC	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain SL1344	salmonellosis	Primates	9606	Homo sapiens (related: human)	Membrane fusogenic activity	reduced virulence	Gene disruption; gene complementation	27777572
C1_01937	ACL32380	70.4	467	0	138	6	472	7	473	9.33e-235	650.0	B8F4X8	PHI:3147	rfaE	738	nan	Glaesserella parasuis	SC096	glasser's disease	Even-toed ungulates	9823	Sus scrofa (related: pig)	Part of cluster invloved in lipooligosaccharide synthesis	reduced virulence	Gene mutation	25078003
C1_01942	CAN01748	40.2	261	7	143	6	261	2	254	7.12e-44	148.0	A5CRN8	PHI:123049	ChpE (CMM_0039)	28447	nan	Clavibacter michiganensis	CMM101	bacterial wilt; bacterial canker	Eudicots	4111	Solanum melongena (related: eggplant)	Effector protein	effector (plant avirulence determinant)	Gene mutation	35441490
C1_01957	ACY90296	80.4	506	0	99	1	506	1	506	5.379999999999999e-242	671.0	A0A0F6B6Z9	PHI:6979	aer	28901	PHI:6980; PHI:6981; PHI:6982; PHI:6983_PHI:6980; PHI:6981; PHI:6982; PHI:6983; PHI:6984_nan_PHI:6980_PHI:6980; PHI:6981_PHI:6980; PHI:6981; PHI:6982; PHI:6983; PHI:6984; PHI:6985_PHI:6980; PHI:6981; PHI:6982	Salmonella enterica	subsp. enterica serovar Typhimurium strain NCTC 12023	salmonellosis	Primates	9606	Homo sapiens (related: human)	Methyl-accepting chemotaxis protein	reduced virulence	Gene deletion: full	28212413
C1_01983	ARA47408	92.3	220	0	17	1	220	1	220	4.94e-146	404.0	W9B383	PHI:11405	dedA	573	nan	Klebsiella pneumoniae	ATCC 43816; MKP203	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	DedA family inner membrane protein	reduced virulence	Gene deletion: full; gene complementation	31988174
C1_02019	ABQ20123	71.5	562	1	159	23	583	1	562	4.19e-295	811.0	A5F6S0	PHI:4108	fadD	666	PHI:4109_nan	Vibrio cholerae	O395	cholera	 hares_Rabbits 	9986	Oryctolagus cuniculus (related: rabbit)	encoding a long-chain fatty acyl coenzyme A (acyl-CoA) ligase	reduced virulence_unaffected pathogenicity	Gene disruption	23918781
C1_02021	AMY26905	56.7	231	2	98	2	231	4	233	1.55e-85	252.0	A0A165G9C3	PHI:6870	yeaZ	669	nan	Vibrio harveyi	SF-1	luminous vibriosis	Bony fishes	7955	Danio rerio (related: zebrafish)	Resuscitation-promoting factor	reduced virulence	Gene disruption	27966258
C1_02027	CBW17849	87.0	192	0	25	1	192	1	192	1.88e-118	332.0	A0A0H3NC59	PHI:9496	yeaB	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Rodents	10090	Mus musculus (related: house mouse)	RNA methyltransferase	reduced virulence	Gene mutation; gene complementation	31487966
C1_02030	AAO56193	52.3	239	3	108	1	233	1	239	3.94e-75	236.0	Q882D7	PHI:3118	PSPTO_2691	317	nan	Pseudomonas syringae	pv. tomato strain DC3000	bacterial speck (tomato)	Eudicots	4081_4097	Solanum lycopersicum (related: tomato)_Nicotiana tabacum (related: common tobacco)	Membrane protein, TerC family	unaffected pathogenicity	Gene mutation	25170934
C1_02037	AEL04135	53.0	183	1	82	7	185	7	189	3.6400000000000003e-59	182.0	G1BJ13	PHI:7899	yebN	347	nan	Xanthomonas oryzae	pv. oryzae strain PXO99A	bacterial leaf blight	Monocots	4530	Oryza sativa (related: rice)	Leader RNA that functions as a sensor for Mn2+	reduced virulence	Gene deletion: partial; gene complementation	29522378
C1_02039	AAC06037	100.0	69	0	0	1	69	1	69	1.66e-47	143.0	P0A9Y9	PHI:7262	cspC	28901	PHI:7263_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain UMR1	salmonellosis	Rodents_Primates	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Cold shock protein	loss of pathogenicity_reduced virulence_unaffected pathogenicity	Gene deletion: full	28611217
C1_02041	CBW17864	73.4	79	0	21	1	79	1	79	2.38e-38	120.0	A0A0H3NC74	PHI:9521	yobH (SL1344_1770)	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain SL1344	gastroenteritis	Rodents_Primates	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Invasion factor	reduced virulence	Gene mutation; gene complementation	31484980
C1_02042	ERO57666	89.4	263	0	28	1	263	1	263	8.6e-166	457.0	U6ZHA8	PHI:4175	kdgR	1089444	nan	Dickeya solani	IFB0123	soft rot	Eudicots	4113	Solanum tuberosum (related: potato)	virulence negative regulators	unaffected pathogenicity	Gene mutation	24625032
C1_02045	BAA00577	99.7	682	0	2	1	682	1	682	0.0	1314.0	P23865	PHI:9896	Prc	562	nan	Escherichia coli	RS218	urinary tract infection	Rodents	10090	Mus musculus (related: house mouse)	Tail-specific protease	reduced virulence	Gene mutation; gene complementation	31900139
C1_02046	AAL20761	87.9	232	2	24	1	232	1	228	2.04e-127	358.0	P60317	PHI:8783	ProQ	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain SL1344	salmonellosis	Rodents_Primates	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	RNA chaperone 	reduced virulence_unaffected pathogenicity	Gene mutation; gene complementation	30602583
C1_02049	ACA68070	68.2	877	1	277	1	877	1	875	0.0	1216.0	A0A0H3B2K4	PHI:11187	MAM (YPK_1779)	633	nan	Yersinia pseudotuberculosis	YP126	zoonotic infection	Moths	7137	Galleria mellonella (related: greater wax moth)	Mammalian cell entry related domain protein	increased virulence (hypervirulence)	Gene deletion: full; gene complementation	33550901
C1_02066	AAA23861	99.2	392	0	3	1	392	1	392	1.75e-280	758.0	P33221	PHI:8653	purT	562	PHI:8652_nan	Escherichia coli	UTI89	infection	Rodents_Primates	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Formate-dependent phosphoribosylglycinamide formyltransferase	reduced virulence_unaffected pathogenicity	Gene deletion: full_Gene deletion: full; gene complementation	30377949
C1_02067	CAG75378	89.2	212	0	23	1	212	1	212	2.25e-134	374.0	Q6D4B5	PHI:11149	eda	29471	nan	Pectobacterium atrosepticum	SCRI1039	soft rot (potato); blackleg disease (potato)	Eudicots	4113	Solanum tuberosum (related: potato)	2-Keto-3-deoxy-6-phosphogluconate aldolase	reduced virulence	Gene deletion: full; gene complementation	33301200
C1_02068	CAG74739	75.7	601	0	146	1	601	1	601	0.0	916.0	Q6D652	PHI:11150	edd	29471	nan	Pectobacterium atrosepticum	SCRI1039	soft rot (potato); blackleg disease (potato)	Eudicots	4113	Solanum tuberosum (related: potato)	Phosphogluconate dehydratase	unaffected pathogenicity	Gene deletion: full; gene complementation	33301200
C1_02074	CAL20697	72.8	419	2	112	22	440	1	417	2.4199999999999998e-225	622.0	Q0WF94	PHI:4185	ypo2062	632	nan	Yersinia pestis	CO92	bubonic plague	Rodents	10090	Mus musculus (related: house mouse)	putative DNA binding protein	reduced virulence	Gene deletion: partial; gene complementation	24675805
C1_02075	AAC74927	100.0	310	0	0	19	328	1	310	6.91e-223	607.0	P39172	PHI:11005	znuA	562	PHI:11006; PHI:11007_nan	Escherichia coli	C83902	infection	Even-toed ungulates	9823	Sus scrofa (related: pig)	Zn(2(+)) ABC transporter periplasmic binding	reduced virulence	Gene deletion: full	33028391
C1_02076	AAC74928	100.0	251	0	0	1	251	1	251	2.04e-183	501.0	P0A9X1	PHI:11007	znuC	562	PHI:11005; PHI:11006_nan	Escherichia coli	C83902	infection	Even-toed ungulates	9823	Sus scrofa (related: pig)	Zn(2(+)) ABC transporter ATP binding subunit	reduced virulence	Gene deletion: full	33028391
C1_02077	AAC74929	94.6	261	0	14	1	261	1	261	1.17e-162	449.0	P39832	PHI:11006	znuB	562	PHI:11005; PHI:11007_nan	Escherichia coli	C83902	infection	Even-toed ungulates	9823	Sus scrofa (related: pig)	Zn(2(+)) ABC transporter membrane subunit	reduced virulence	Gene deletion: full	33028391
C1_02097	AAL20829	95.4	692	0	32	1	692	1	692	0.0	1242.0	P40729	PHI:8731	flhA	28901	PHI:8727_PHI:8727; PHI:8728; PHI:8729	Salmonella enterica	subsp. enterica serovar Typhimurium strain SL1344	typhoid	Rodents	10090	Mus musculus (related: house mouse)	Flagellar biosynthesis protein	reduced virulence	Gene mutation	30379938
C1_02098	AAC74950	99.5	382	0	2	1	382	1	382	4.36e-269	729.0	P76299	PHI:11174	flhB	562	nan	Escherichia coli	serotype O157:H7 strain EDL933	neonatal sepsis; neonatal meningitis	 hares_Rabbits _Primates	9986_9606	Homo sapiens (related: human)_Oryctolagus cuniculus (related: rabbit)	Flagellar biosynthetic protein 	reduced virulence	Gene deletion: full; gene complementation	33688013
C1_02099	AAL20831	93.0	214	0	15	1	214	1	214	9.859999999999999e-134	372.0	P07800	PHI:10050	chez_cheZ	28901	PHI:10046; PHI:10047; PHI:10048; PHI:10051_PHI:10046; PHI:10047; PHI:10048	Salmonella enterica	subsp. enterica serovar Typhimurium strain NCTC 12023	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Protein phosphatase/ chemotactic response protein_Chemotaxis regulator protein	reduced virulence	Gene mutation; gene complementation	31826974
C1_02100	AAL20832	97.7	129	0	3	1	129	1	129	2.38e-86	246.0	P0A2D5	PHI:10049_PHI:8732	cheY	28901	PHI:8727_PHI:8727; PHI:8728; PHI:8729_PHI:10046; PHI:10047; PHI:10048; PHI:10051_PHI:10046; PHI:10047; PHI:10048	Salmonella enterica	subsp. enterica serovar Typhimurium strain NCTC 12023_subsp. enterica serovar Typhimurium strain SL1344	typhoid_salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Chemotaxis regulator protein	reduced virulence	Gene mutation; gene complementation_Gene mutation	30379938_31826974
C1_02101	AAL20833	95.4	349	0	16	1	349	1	349	4.61e-236	642.0	P04042	PHI:6461	cheB	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain IR715	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Chemotaxis	reduced virulence	Gene mutation	27435462
C1_02102	AAL20834	87.4	286	0	36	1	286	1	286	8.350000000000001e-185	508.0	P07801	PHI:11916	cheR	28901	PHI:11917_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028s	infection	Rodents_Primates	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Chemotaxis protein methyltransferase	reduced virulence_increased virulence (hypervirulence)	Altered gene expression / gene regulation: overexpression_Gene deletion: full; gene complementation	34544273
C1_02103	ACY90220	44.8	268	2	146	158	424	158	424	4.75e-36	139.0	A0A0F6B6S3	PHI:6985	mcpB	28901	PHI:6979; PHI:6980; PHI:6981; PHI:6982; PHI:6983; PHI:6984	Salmonella enterica	subsp. enterica serovar Typhimurium strain NCTC 12023	salmonellosis	Primates	9606	Homo sapiens (related: human)	Methyl-accepting chemotaxis protein	reduced virulence	Gene deletion: full	28212413
C1_02104	AAL20835	78.3	554	2	118	1	553	1	553	9.57e-233	651.0	P02941	PHI:6983	cheM	28901	PHI:6979; PHI:6980; PHI:6981; PHI:6982; PHI:6984_PHI:6979; PHI:6980; PHI:6981; PHI:6982_PHI:6979; PHI:6980; PHI:6981; PHI:6982; PHI:6984; PHI:6985	Salmonella enterica	subsp. enterica serovar Typhimurium strain NCTC 12023	salmonellosis	Primates	9606	Homo sapiens (related: human)	Methyl-accepting chemotaxis protein	reduced virulence	Gene deletion: full_Gene deletion: full; gene complementation	28212413
C1_02105	AAA23565	100.0	167	0	0	1	167	1	167	1.4e-110	310.0	P0A964	PHI:6536	cheW	562	PHI:6535	Escherichia coli	XM	meningitis	Birds	8839	Anas platyrhynchos (related: mallard)	Chemotaxis protein	unaffected pathogenicity	Gene mutation	26099584
C1_02106	AAA23573	99.4	654	0	4	1	654	1	654	0.0	1219.0	P07363	PHI:6535	cheA	562	PHI:6536_nan	Escherichia coli	XM	meningitis	Birds	8839	Anas platyrhynchos (related: mallard)	Chemotaxis protein	reduced virulence_unaffected pathogenicity	Gene mutation	26099584
C1_02107	AAA24178	100.0	308	0	0	1	308	1	308	1.0299999999999999e-216	590.0	P0AF06	PHI:6534	motB	562	nan	Escherichia coli	XM	meningitis	Birds	8839	Anas platyrhynchos (related: mallard)	Motility protein	reduced virulence	Gene mutation	26099584
C1_02108	AAA24177	99.7	295	0	1	1	295	1	295	4.43e-200	547.0	P09348	PHI:6533	motA	562	nan	Escherichia coli	XM	meningitis	Birds	8839	Anas platyrhynchos (related: mallard)	Motility protein	reduced virulence	Gene mutation	26099584
C1_02109	ADM99088	83.3	192	0	32	1	192	1	192	5.77e-113	318.0	E0SIM9	PHI:8572	flhC (Dda3937_02784)	204038	PHI:8571	Dickeya dadantii	3937	soft rot	Eudicots	13427	Cichorium intybus (related: chicory)	Flagellar transcriptional activator	reduced virulence	Gene deletion: full	30267562
C1_02110	AAB96639	89.7	116	1	9	1	116	1	113	5.55e-67	196.0	P0A2R2	PHI:9419_PHI:7271	flhDC_flhD	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain SL1344	salmonellosis_gastroenteritis	Bony fishes_Primates	7955_9606	Homo sapiens (related: human)_Danio rerio (related: zebrafish)	Flagellar transcriptional regulator_Regulatory protein	reduced virulence_increased virulence (hypervirulence)	Gene mutation	28704543_31428591
C1_02112	CAD18256	55.8	462	6	192	1	452	1	460	1.47e-177	504.0	Q8XQW3	PHI:9814	otsA	305	PHI:9815; PHI:9816_nan	Ralstonia solanacearum	GMI1000	bacterial wilt	Eudicots	4081	Solanum lycopersicum (related: tomato)	Trehalose-6-phosphate synthase	reduced virulence	Gene deletion: full	31765286
C1_02129	AAO68606	96.3	218	0	8	1	218	1	218	3.64e-147	407.0	P96058	PHI:560	sirA	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain SL1344	gastroenteritis	Rodents	10090	Mus musculus (related: house mouse)	nan	reduced virulence	Other evidence	16113260
C1_02131	AAC44036	40.8	238	0	141	3	240	4	241	4.39e-56	177.0	P54292	PHI:7656_PHI:123420_PHI:6996_PHI:9366_PHI:8822_PHI:6748_PHI:8547_PHI:9432	rhlR_RhlR	287	PHI:7655_PHI:1_nan_PHI:8821_PHI:9367; PHI:9368	Pseudomonas aeruginosa	PAO1_PA14	cystic fibrosis_urinary tract infection_opportunistic infection_nosocomial infection_infection	Nematodes_Primates_Rodents	6239_10090_9606	Homo sapiens (related: human)_Caenorhabditis elegans (related: roundworm)_Mus musculus (related: house mouse)	HTH-type quorum-sensing regulator RhlR_QSS regulatory protein_Regulatory protein_Quorum-sensing receptor_Transcriptional regulator_Acyl-homoserine-lactone-dependent quorum sensing system	loss of pathogenicity_reduced virulence_unaffected pathogenicity	Gene mutation_Gene mutation_Gene mutation; gene complementation	36033859_30224496_29089927_27549211_31379861_30707095_28246361_31194839
C1_02132	AAF41202	55.3	244	2	104	4	244	2	243	6.54e-84	249.0	Q9K033	PHI:8623	cab (NMB0789)	487	nan	Neisseria meningitidis	NIID84 Δcps	septicemia	Primates	9606	Homo sapiens (related: human)	Cysteine ATP binding protein	unaffected pathogenicity	Other evidence: ectopic complementation	30538184
C1_02133	AAF41201	56.4	163	0	71	54	216	54	216	1.1100000000000001e-57	180.0	Q9K034	PHI:8622	ctp (NMB0788)	487	nan	Neisseria meningitidis	NIID84 Δcps	septicemia	Primates	9606	Homo sapiens (related: human)	Cysteine transporter permease	unaffected pathogenicity	Other evidence: ectopic complementation	30538184
C1_02136	BAA36398	79.2	183	0	38	1	183	1	183	9.6e-103	291.0	P0A210	PHI:9178	FliZ	28901	PHI:9177	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Flagellar protein	reduced virulence	Gene mutation	29378886
C1_02138	AAF71893	58.1	616	16	190	1	579	1	585	3.03e-139	415.0	Q9K2Y6	PHI:7845	fliC	562	PHI:7846_nan	Escherichia coli	F11	neonatal meningitis	Rodents	10090	Mus musculus (related: house mouse)	Flagellin protein	reduced virulence_unaffected pathogenicity	Gene mutation	29311232
C1_02139	AAC74991	99.6	468	0	2	1	468	1	468	5.64e-281	766.0	P24216	PHI:6733	fliD	562	nan	Escherichia coli	EDL933	urinary tract infection	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	Flagellar filament capping protein	unaffected pathogenicity	Gene mutation; gene complementation	27655246
C1_02145	AAL20878	100.0	77	0	0	1	77	1	77	5.62e-54	160.0	P0AA34	PHI:7643	yedF	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain SL1344	salmonellosis	Primates	9606	Homo sapiens (related: human)	Hypothetical transcription factor	reduced virulence	Gene mutation; gene complementation	29127378
C1_02150	CAR43401	58.8	560	6	202	14	550	19	572	4.21e-214	604.0	B4EYL5	PHI:123276	fliF	584	nan	Proteus mirabilis	HI4320	urinary tract infection; urolithiasis	Primates	9606	Homo sapiens (related: human)	Flagellar M-ring protein	reduced virulence	Gene deletion	35651758
C1_02153	AE004540_13	62.4	410	1	147	29	438	29	431	2.7999999999999995e-172	489.0	Q9I4N1	PHI:6995	Flil	287	nan	Pseudomonas aeruginosa	PA14	opportunistic infection	Rodents	10090	Mus musculus (related: house mouse)	Flagellin	reduced virulence	Gene mutation	28246361
C1_02154	AAA27102	87.8	147	0	18	1	147	1	147	6.37e-86	246.0	P0A1K1	PHI:6463	filj	28901	PHI:6464; PHI:6462_nan_PHI:6460; PHI:6462; PHI:6464	Salmonella enterica	subsp. enterica serovar Typhimurium strain IR715	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Flagellar protein	reduced virulence	Gene mutation	27435462
C1_02162	TXE36820	66.7	255	0	85	1	255	1	255	1.43e-114	328.0	A0A5C7CFY5	PHI:12274_PHI:12273_PHI:12270_PHI:12269	FliR	615	nan	Serratia marcescens	RM66262_Db10	opportunistic infection	Flies	7227	Drosophila melanogaster (related: fruit fly)	Flagellar biosynthetic protein FliR	reduced virulence	Gene disruption; gene complementation	35197500
C1_02163	AAL20894	87.9	207	0	25	1	207	1	207	7.24e-128	357.0	P54698	PHI:3013	rcsA	28901	PHI:3011	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	food poisoning	Rodents	10090	Mus musculus (related: house mouse)	Positive regulator of capsular polysaccharide synthesis. RcsA and RcsB form a complex to promote transcription of the genes for capsule synthesis.	increased virulence (hypervirulence)	Gene mutation	15469511
C1_02180	AIK72111	42.5	221	1	121	39	253	4	224	1.08e-53	172.0	X5KI93	PHI:123346	covR	1311	nan	Streptococcus agalactiae	874391	pneumonia; meningitis	Rodents	10090	Mus musculus (related: house mouse)	DNA-binding response regulator	reduced virulence	Gene mutation	35862444
C1_02181	AAL20029	68.4	136	0	43	2	137	1	136	3.31e-67	198.0	Q8ZQ52	PHI:2651	yedX	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain SL1344	food poisoning	Birds_Rodents	9031_10090	Gallus gallus (related: chicken)_Mus musculus (related: house mouse)	Cyclic amidohydrolase that hydrolyses 5-hydroxyisourate (5-HIU)	unaffected pathogenicity	Gene disruption	23284609
C1_02184	BBD29223	53.3	182	0	85	42	223	330	511	1.74e-62	201.0	A0A2Z6BW49	PHI:12225	adcA	1351	PHI:12226; PHI:12227; PHI:12228_PHI:12226; PHI:12227_PHI:12228_nan	Enterococcus faecalis	OG1RF	nosocomial infection	Moths_Rodents	7137_10090	Galleria mellonella (related: greater wax moth)_Mus musculus (related: house mouse)	ABC-type transporter	reduced virulence_unaffected pathogenicity	Gene deletion: full; gene complementation	35341449
C1_02190	CAA88188	40.4	381	5	213	170	537	69	448	1.95e-81	286.0	Q56889	PHI:6252	Inv	630	nan	Yersinia enterocolitica	serotype O:8	yersiniosis	Rodents	10090	Mus musculus (related: house mouse)	Invasin	reduced virulence	Gene mutation	27107739
C1_02198	ACT12440	70.3	317	1	93	1	316	1	317	5.13e-159	445.0	C6DD61	PHI:10578	PccS1_002702	554	nan	Pectobacterium carotovorum	subsp. carotovorum strain PccS1	soft rot	Monocots	69721	Zantedeschia aethiopica (related: arum-lily)	Transcriptional regulator, LysR family	unaffected pathogenicity	Gene deletion: full; gene complementation	32267092
C1_02199	ARF49911	70.8	305	0	89	1	305	1	305	3.41e-149	419.0	H3RDZ6	PHI:12254	nac	66269	nan	Pantoea stewartii	subsp. stewartii	stewart's wilt; leaf blight (maize)	Monocots	4577	Zea mays (related: maize)	Nitrogen assimilation transcriptional regulator	unaffected pathogenicity	Gene deletion: full; gene complementation	35237242
C1_02210	EAT92394	55.6	482	3	205	3	481	8	483	3.24e-190	538.0	Q0V515	PHI:3914	Sdh1	13684	nan	Parastagonospora nodorum	SN15	stagonospora nodorum blotch	Monocots	4565	Triticum aestivum (related: bread wheat)	encodes succinic semialdehyde dehydrogenase	reduced virulence	Gene disruption; gene complementation	24265684
C1_02214	AAW65729	48.7	39	0	20	109	147	423	461	8.65e-06	42.7	Q3BDH0	PHI:4150	LruA	173	nan	Leptospira interrogans	serovar Manilae strain L495	leptospirosis	Rodents	10036	Mesocricetus auratus (related: golden hamster)	lipoprotein that has been implicated in leptospiral uveitis as a target of the immune response	reduced virulence	Gene mutation	23918777
C1_02226	AIS99989	91.5	400	0	34	1	400	1	400	1.55e-262	714.0	A0A086IQC3	PHI:8968	proV	573	nan	Klebsiella pneumoniae	KPPR1	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Glycine betaine/L-proline transport ATP-binding protein	reduced virulence	Gene deletion: full	29712730
C1_02232	CAA38090	100.0	176	0	0	1	176	1	176	6.350000000000001e-125	347.0	P0ACR9	PHI:5407_PHI:7646	MprA_mprA	562	nan	Escherichia coli	UTI89_PA45B	urinary tract infection	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Transcriptional repressor_Transcriptional repressor of an operon encoding the EmrAB efflux pump.	loss of pathogenicity_reduced virulence	Gene mutation; gene complementation	29066548_26671885
C1_02235	ABJ02122	99.4	171	0	1	1	171	1	171	1.4600000000000002e-123	343.0	A1AEN2	PHI:3731	LuxS	562	nan	Escherichia coli	serotype O78:K80:H9 strain χ7122	colibacillosis; cellulitis; swollen head syndrome	Birds	9031	Gallus gallus (related: chicken)	controller in the Quorum sensing	reduced virulence	Gene deletion; gene complementation	23958403
C1_02236	AE004933_4	44.4	475	8	244	25	494	27	486	3.97e-128	382.0	Q9HTY6	PHI:11327_PHI:9280	gshA	287	PHI:9281_nan	Pseudomonas aeruginosa	PAO1	urinary tract infection	Rodents	10090	Mus musculus (related: house mouse)	Glutamate-cysteine ligase_Glutamate--cysteine ligase	reduced virulence	Gene deletion; gene complementation_Gene deletion: full	31157178_32284368
C1_02244	CSRA_SALTY	100.0	61	0	0	1	61	1	61	7.71e-36	113.0	P69917	PHI:2682	csrA	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028s	food poisoning	Rodents	10090	Mus musculus (related: house mouse)	Regulators of systemic infection	reduced virulence	Gene deletion: full; gene complementation	19229334
C1_02247	ABO12389	74.1	328	0	85	3	330	1	328	7.19e-174	485.0	A3M645	PHI:10380	RecA	470	nan	Acinetobacter baumannii	ATCC 17978	nosocomial infection	Nematodes_Moths	6239_7137	Galleria mellonella (related: greater wax moth)_Caenorhabditis elegans (related: roundworm)	DNA strand exchange and recombination protein	reduced virulence	Gene deletion: full; gene complementation	32255384
C1_02250	ACY89836	97.3	187	0	5	1	187	1	187	2.9800000000000003e-133	369.0	A0A0F6B5P2	PHI:10052	STM14_RS15195 (srlA)	28901	PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	PTS sorbitol transporter subunit IIC	unaffected pathogenicity	Gene deletion: full	32038592
C1_02251	ACY89837	92.3	323	2	21	1	319	1	323	5.3899999999999996e-214	584.0	A0A0F6B5P3	PHI:10053	STM14_RS15200 (srlE)	28901	PHI:10052; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	PTS sorbitol transporter subunit IIB	unaffected pathogenicity	Gene deletion: full	32038592
C1_02252	ACY89838	81.4	118	0	22	1	118	1	118	3.36e-69	202.0	A0A0F6B5P4	PHI:10054	STM14_RS15205 (slrB)	28901	PHI:10052; PHI:10053; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	PTS glucitol/sorbitol transporter subunit IIA	unaffected pathogenicity	Gene deletion: full	32038592
C1_02253	ACY89839	97.7	259	0	6	1	259	1	259	4.950000000000001e-179	491.0	A0A0F6B5P5	PHI:10055	STM14_RS15210 (srlD)	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Sorbitol-6-phosphate dehydrogenase	unaffected pathogenicity	Gene deletion: full	32038592
C1_02254	ACY89840	83.2	119	0	20	1	119	1	119	3.7699999999999996e-67	196.0	A0A0F6B5P6	PHI:10056	STM14_RS15215 (gutM)	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Transcriptional regulator	unaffected pathogenicity	Gene deletion: full	32038592
C1_02255	ACY89842	94.9	257	0	13	1	257	1	257	7.54e-173	475.0	A0A0F6B5P8	PHI:10058	STM14_RS15225	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Arabinose 5-phosphate isomerase	unaffected pathogenicity	Gene deletion: full	32038592
C1_02256	ACY89843	92.8	321	0	23	1	321	1	321	5.790000000000002e-209	572.0	A0A0F6B5P9	PHI:10059	STM14_RS15230	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	NorR family transcriptional regulator	unaffected pathogenicity	Gene deletion: full	32038592
C1_02257	ACY89844	88.8	507	2	53	1	504	1	506	9.61e-317	860.0	A0A0F6B5Q0	PHI:10060	STM14_RS15235	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Anaerobic nitric oxide reductase flavorubredoxin	unaffected pathogenicity	Gene deletion: full	32038592
C1_02258	KAE9675871	99.8	479	0	1	1	479	1	479	0.0	986.0	A0A6C8TBQ7	PHI:10668	norV	562	PHI:10669	Escherichia coli	serotype O91:H21 strain B2F1_serotype O157:H7 strain 620	infection	rodents	10090	Mus musculus (related: house mouse)	Anaerobic nitric oxide reductase flavorubredoxin	reduced virulence_unaffected pathogenicity	Gene deletion: full	32825770
C1_02259	BAA05934	99.2	377	0	3	1	377	1	377	6.95e-268	725.0	P37596	PHI:10669	norW	562	PHI:10668	Escherichia coli	serotype O91:H21 strain B2F1_serotype O157:H7 strain 620	infection	rodents	10090	Mus musculus (related: house mouse)	NO reductase	reduced virulence_unaffected pathogenicity	Gene deletion: full	32825770
C1_02260	ACY89848	84.7	743	0	114	1	743	1	743	0.0	1218.0	A0A0F6B5Q4	PHI:10063	STM14_RS15250	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Electron transport protein	unaffected pathogenicity	Gene deletion: full	32038592
C1_02261	ACY89850	96.0	173	0	7	1	173	1	173	8.85e-126	349.0	A0A0F6B5Q6	PHI:10064	STM14_RS15255	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Hypothetical protein	unaffected pathogenicity	Gene deletion: full	32038592
C1_02267	ACY89852	70.5	244	1	70	6	247	22	265	1.63e-128	363.0	A0A0F6B5Q8	PHI:10065	STM14_RS15260	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Hydrogenase maturation peptidase	unaffected pathogenicity	Gene deletion: full	32038592
C1_02268	ACY89853	92.3	155	0	12	1	155	1	155	1.6099999999999999e-106	299.0	A0A0F6B5Q9	PHI:10066	STM14_RS15265	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Formate hydrogenlyase maturation protein	unaffected pathogenicity	Gene deletion: full	32038592
C1_02269	ACY89854	90.4	136	0	13	1	136	1	136	2.93e-88	251.0	A0A0F6B5R0	PHI:10067	STM14_RS15270	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	NADH-quinone oxidoreductase subunit	unaffected pathogenicity	Gene deletion: full	32038592
C1_02270	ACY89855	96.5	255	0	9	1	255	1	255	9.71e-184	502.0	A0A0F6B5R1	PHI:10068	STM14_RS15275	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Formate hydrogenlyase complex iron-sulfur subunit	unaffected pathogenicity	Gene deletion: full	32038592
C1_02271	ACY89856	97.2	178	0	5	1	178	1	178	1.0400000000000001e-116	327.0	A0A0F6B5R2	PHI:10069	STM14_RS15280	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Formate hydrogenlyase subunit 5	unaffected pathogenicity	Gene deletion: full	32038592
C1_02272	ACY89857	96.8	569	0	18	1	569	1	569	0.0	1132.0	A0A0F6B5R3	PHI:10070	STM14_RS15285	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Formate hydrogenlyase subunit 4	unaffected pathogenicity	Gene deletion: full	32038592
C1_02273	ACY89858	90.2	307	0	30	1	307	1	307	6.17e-197	540.0	A0A0F6B5R4	PHI:10071	STM14_RS15290	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Formate hydrogenlyase subunit 3	unaffected pathogenicity	Gene deletion: full	32038592
C1_02274	ACY89859	89.0	608	0	67	1	608	1	608	0.0	1040.0	A0A0F6B5R5	PHI:10072	STM14_RS15295	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Formate hydrogenlyase subunit 2	unaffected pathogenicity	Gene deletion: full	32038592
C1_02275	ACY89860	95.5	202	0	9	1	202	1	202	3.3e-140	388.0	A0A0F6B5R6	PHI:10073	STM14_RS15300	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Formate hydrogenlyase regulator	unaffected pathogenicity	Gene deletion: full	32038592
C1_02276	ACY89862	88.8	152	0	17	1	152	1	152	1.56e-98	278.0	A0A0F6B5R8	PHI:10074	STM14_RS15305	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Hydrogenase maturation nickel metallochaperone	unaffected pathogenicity	Gene deletion: full	32038592
C1_02277	ACY89864	87.0	115	0	15	1	115	1	115	2.2e-74	214.0	A0A0F6B5S0	PHI:10075	STM14_RS15310	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Hydrogenase nickel incorporation protein	unaffected pathogenicity	Gene deletion: full	32038592
C1_02278	ACY89865	94.5	290	0	16	1	290	1	290	3.99e-205	559.0	A0A0F6B5S1	PHI:10076	STM14_RS15315	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Hydrogenase assembly chaperone	unaffected pathogenicity	Gene deletion: full	32038592
C1_02279	ACY89866	96.7	90	0	3	1	90	1	90	2.01e-62	182.0	A0A0F6B5S2	PHI:10077	STM14_RS15320	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Hydrogenase formation protein	unaffected pathogenicity	Gene deletion: full	32038592
C1_02280	ACY89867	94.9	372	0	19	1	372	1	372	2.25e-271	734.0	A0A0F6B5S3	PHI:10078	STM14_RS15325	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Hydrogenase expression/formation protein	unaffected pathogenicity	Gene deletion: full	32038592
C1_02281	ACY89868	92.0	336	0	27	1	336	1	336	3.41e-220	601.0	A0A0F6B5S4	PHI:10079	STM14_RS15330	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Formate hydrogenlyase transcriptional activator	unaffected pathogenicity	Gene deletion: full	32038592
C1_02282	NAO52100	42.4	356	4	179	345	686	99	442	2.6999999999999998e-70	234.0	A0A1I5AAS6	PHI:10620	aauR	317	nan	Pseudomonas syringae	pv. tomato strain DC3000_pv. syringae strain B728a	bacterial speck (tomato)_brown spot (bean)	Eudicots	3885_3702	Arabidopsis thaliana (related: thale cress)_Phaseolus vulgaris (related: kidney bean)	Two-component system, response regulator 	reduced virulence	Gene deletion: full; gene complementation	32673374
C1_02283	ACY89870	86.8	114	0	15	1	114	1	114	6.73e-73	211.0	A0A0F6B5S6	PHI:10081	STM14_RS15340	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097; PHI:10098	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	Iron ABC transporter substrate-binding protein	unaffected pathogenicity	Gene deletion: full	32038592
C1_02298	BAA02747	99.7	330	0	1	1	330	1	330	8.899999999999999e-229	622.0	P13445	PHI:7256	RpoS	562	nan	Escherichia coli	E2348/69_LRT9	diarrhea	Primates	9606	Homo sapiens (related: human)	RNA polymerase sigma factor	unaffected pathogenicity	Gene mutation	28662183
C1_02299	ACN50512	57.4	387	7	103	1	379	1	333	3.6399999999999996e-136	390.0	Q7CKC8	PHI:9369	nlpD	632	nan	Yersinia pestis	Kim53	bubonic plague	Rodents	10090	Mus musculus (related: house mouse)	Lipoprotein	reduced virulence	Gene mutation; gene complementation	31170147
C1_02300	AAL21806	94.2	208	0	12	1	208	1	208	3.02e-141	391.0	Q8ZMF9	PHI:6187	pimt	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain E-2375	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Protein isoaspartate methyl transferase	reduced virulence	Gene mutation; gene complementation	27156953
C1_02303	AAM36589	53.9	154	0	71	1	154	5	158	1.49e-54	168.0	Q8PLR7	PHI:4145	XAC1722	346	nan	Xanthomonas citri	subsp. citri	canker (citrus)	Eudicots	2711	Citrus sinensis (related: sweet orange)	2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	reduced virulence	Gene mutation	24676796
C1_02308	ACD60244	54.2	397	1	181	36	432	1	396	3.12e-150	439.0	B2SI02	PHI:1139	raxQ	347	nan	Xanthomonas oryzae	pv. oryzae strain PXO99A	bacterial blight	Monocots	4530	Oryza sativa (related: rice)	Adenylylsulfate kinase protein required for Ax21 (synonym: AvrXa21) activity	increased virulence (hypervirulence)	Gene disruption; gene complementation	11967067
C1_02309	ACD60245	67.0	297	0	98	6	302	6	302	2.0100000000000003e-144	407.0	B2SI03	PHI:1138	raxP (cysD)	347	nan	Xanthomonas oryzae	pv. oryzae strain PXO99A	bacterial blight	Monocots	4530	Oryza sativa (related: rice)	Sulfate adenylyltransferase (ATP) required for Ax21 activity	increased virulence (hypervirulence)	Gene disruption; gene complementation	11967067
C1_02311	AHS41752	70.5	668	1	196	15	681	1	668	0.0	968.0	A0A638ILJ8	PHI:9967	cas3 (AV79_16420)	28901	nan	Salmonella enterica	subsp. enterica serovar Enteritidis strain SE211	food poisoning	Birds_Even-toed ungulates_Primates_Rodents	9823_9031_10090_9606	Homo sapiens (related: human)_Sus scrofa (related: pig)_Gallus gallus (related: chicken)_Mus musculus (related: house mouse)	CRISPR-associated helicase/endonuclease	reduced virulence	Gene deletion: full; gene complementation	31936769
C1_02314	CBA19698	83.1	567	0	96	3	569	4	570	0.0	992.0	D4HWM2	PHI:9323	cysI3	552	nan	Erwinia amylovora	HKN06P1	fire blight	Eudicots	3750_4097	Malus domestica (related: apple)_Nicotiana tabacum (related: common tobacco)	Sulfite reductase	unaffected pathogenicity	Gene mutation	31152019
C1_02315	ADM99812	75.5	608	3	139	1	599	1	607	0.0	893.0	E0SDK2	PHI:8574	cysJ (Dda3937_00209)	204038	nan	Dickeya dadantii	3937	soft rot	Eudicots	13427	Cichorium intybus (related: chicory)	Sulfite reductase alpha subunit	reduced virulence	Gene deletion: full	30267562
C1_02321	ABP90468	55.1	430	4	182	1	424	1	425	2.93e-146	422.0	A4VWH9	PHI:11234	Eno	1307	nan	Streptococcus suis	CVCC606	meningitis; septicemia; arthritis; pneumonia (pig)	Even-toed ungulates_Rodents	9823_10090	Sus scrofa (related: pig)_Mus musculus (related: house mouse)	Enolase	unaffected pathogenicity	Functional test in host	33618766
C1_02326	AAO70421	96.1	743	0	29	1	743	1	743	0.0	1439.0	Q8Z447	PHI:9161	RelA	28901	PHI:9162	Salmonella enterica	subsp. enterica serovar Typhi strain Ty2_subsp. enterica serovar Typhimurium strain SL1344	salmonellosis	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	GTP pyrophosphokinase	reduced virulence	Gene deletion: full; gene complementation	31013389
C1_02328	AAO70423	90.0	921	2	86	1	918	1	918	0.0	1624.0	Q8Z445	PHI:562	barA	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain SL1344	gastroenteritis	Rodents	10090	Mus musculus (related: house mouse)	nan	unaffected pathogenicity	Gene deletion	16113260
C1_02359	AAC75856	100.0	417	0	0	1	417	1	417	3.21e-291	788.0	P63883	PHI:10980	amiC	562	PHI:10979_nan	Escherichia coli	PCN033	infection	Even-toed ungulates_Rodents	9823_10036_10090	Mesocricetus auratus (related: golden hamster)_Sus scrofa (related: pig)_Mus musculus (related: house mouse)	N-acetylmuramoyl-L-alanine amidase	reduced virulence	Gene deletion: full	32962530
C1_02372	AF116285_1	67.8	152	0	49	1	152	1	152	3.7300000000000006e-79	231.0	Q9X4P2	PHI:7474	PA0336 (RppH)	287	nan	Pseudomonas aeruginosa	PAO1161	infection	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	Nudix-type RNA pyrophosphohydrolase	increased virulence (hypervirulence)	Gene mutation; gene complementation	28833678
C1_02381	ADM99914	73.9	418	0	109	1	418	1	418	2.15e-233	642.0	E0SEI0	PHI:8581	lysA (Dda3937_02577)	204038	nan	Dickeya dadantii	3937	soft rot	Eudicots	13427	Cichorium intybus (related: chicory)	Diamiopimelate decarboxylase	reduced virulence	Gene deletion: full	30267562
C1_02385	QHP58461	83.8	253	0	41	1	253	1	253	1.12e-156	434.0	A0A518VKX7	PHI:10587	kduD	554	nan	Pectobacterium carotovorum	subsp. carotovorum strain PccS1	soft rot	Monocots	69721	Zantedeschia aethiopica (related: arum-lily)	2-Dehydro-3-deoxy-D-gluconate 5-dehydrogenase	unaffected pathogenicity	Gene deletion: full; gene complementation	32267092
C1_02387	XP_747207	42.4	394	4	222	1	390	4	396	1.4e-95	290.0	Q4WCL5	PHI:2529	ERG10	746128	nan	Aspergillus fumigatus	CEA10	invasive pulmonary aspergillosis	Lethal pathogen phenotype	Lethal pathogen phenotype	Lethal pathogen phenotype	Acetyl-CoA acetyl-transferase	lethal	Altered gene expression / gene regulation	17352532
C1_02403	ABP91129	49.6	619	1	311	3	620	5	623	7.5e-203	581.0	A4VYE0	PHI:11091	gidA	1307	PHI:11090	Streptococcus suis	SC19	meningitis; septicemia; streptococcal toxic shock syndrome	Rodents	10090	Mus musculus (related: house mouse)	tRNA uridine 5-carboxymethylaminomethyl modification enzyme	reduced virulence	Gene deletion: full; gene complementation	33425782
C1_02406	ACY91043	96.3	271	0	10	1	271	1	271	3.63e-187	512.0	A0A0F6B941	PHI:9436	atpB	28901	PHI:9435	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	gastroenteritis	Rodents	10090	Mus musculus (related: house mouse)	F0F1 ATP synthase subunit A	reduced virulence	Gene mutation	31346161
C1_02410	ABD31377	53.7	512	3	224	1	512	1	499	5.3899999999999996e-182	518.0	Q2FWE8	PHI:10773	atpA	1280	nan	Staphylococcus aureus	USA300 LAC 13C	prosthetic joint infection	Rodents_Primates	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	ATP synthase subunit alpha	reduced virulence	Gene deletion: full; gene complementation	32900803
C1_02414	ACC58902	55.8	450	0	199	7	456	4	453	2.09e-177	503.0	B2I2B5	PHI:8042	lpxA	470	nan	Acinetobacter baumannii	ATCC 19606	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	N-acetylglucosamine-1-phosphate uridyltransferase	reduced virulence	Gene mutation; gene complementation	29638177
C1_02415	CBA24212	84.1	609	0	97	1	609	1	609	0.0	1005.0	D4I4L2	PHI:9308	glmS	552	nan	Erwinia amylovora	HKN06P1	fire blight	Eudicots	3750	Malus domestica (related: apple)	Glucosamine-fructose-6-phosphateaminotransferase	reduced virulence	Gene mutation	31152019
C1_02417	AUU95693	40.3	216	4	123	23	237	6	216	1.74e-48	157.0	A0A086ITU0	PHI:10209	fimC	573	nan	Klebsiella pneumoniae	TOP52	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Molecular chaperone	unaffected pathogenicity	Gene deletion: full	29158434
C1_02423	AAM36442	66.5	251	0	84	7	257	17	267	1.2300000000000002e-125	356.0	Q8PM59	PHI:3412	pstB	346	nan	Xanthomonas citri	subsp. citri strain 306	canker (citrus)	Eudicots	171249_2711	Citrus limonia (related: mandarin lime)_Citrus sinensis (related: sweet orange)	phosphate metabolism	loss of pathogenicity	Gene mutation	25403594
C1_02424	QPQ67540	95.4	238	0	11	1	238	1	238	4.21e-162	446.0	A0A5W0R9X0	PHI:123166	phoU	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028s	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Phosphate-specific transport system accessory protein PhoU	loss of pathogenicity_reduced virulence	Gene mutation: characterised_Gene deletion: full_Gene mutation: characterised; gene deletion: full	35638741
C1_02425	AAA23509	100.0	278	0	0	1	278	1	278	1.5999999999999998e-189	519.0	P11989	PHI:4630	PafR	562	PHI:4631_nan	Escherichia coli	CFT073	urinary tract infection	Rodents	10090	Mus musculus (related: house mouse)	Transcription Regulator	reduced virulence	Gene deletion: full; gene complementation	25069986
C1_02435	CBA24187	83.4	433	0	72	13	445	5	437	9.13e-248	680.0	D4I4J9	PHI:10919	EaAdeP (EAMY 3685)	552	nan	Erwinia amylovora	1189	fire blight	Eudicots	3750_23211	Malus domestica (related: apple)_Pyrus communis (related: pear)	Putative AzgA family transporter	reduced virulence	Gene mutation; gene complementation	33152083
C1_02441	AAA24676	100.0	471	0	0	1	471	1	471	0.0	946.0	P0A853	PHI:7966	tnaA	562	PHI:7964_nan	Escherichia coli	EDL933	urinary tract infection	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	Tryptophanase	reduced virulence	Gene mutation	29515100
C1_02461	AAN33263	57.6	139	2	56	1	136	1	139	7.49e-47	147.0	Q8FXL4	PHI:4102	ibpA	29461	nan	Brucella suis	1330	brucellosis	Rodents	10090	Mus musculus (related: house mouse)	heat-shock chaperone	unaffected pathogenicity	Gene deletion: full	24517122
C1_02496	ACY90898	80.4	567	0	111	1	567	1	567	0.0	916.0	A0A0F6B8Q0	PHI:9177	HilE (STM14_4514)	28901	nan_PHI:9178	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Putative inner membrane protein	reduced virulence	Gene mutation	29378886
C1_02502	AKH09371	98.2	703	1	12	1	702	1	703	0.0	1343.0	A0A0D6I2I2	PHI:10548	spoT	28901	nan_PHI:10549	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	(P)ppGpp synthetase	reduced virulence_unaffected pathogenicity	Gene deletion: full_Gene mutation	32098823
C1_02510	AAL22592	96.2	213	0	8	1	213	1	213	3.02e-148	409.0	P08870	PHI:7662	pyrE	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain HA431	salmonellosis	Birds_Even-toed ungulates_Rodents	9913_9031_10090	Bos taurus (related: cattle)_Gallus gallus (related: chicken)_Mus musculus (related: house mouse)	Orotate phosphoribosyltransferase	reduced virulence_unaffected pathogenicity	Gene deletion: full; chemical complementation	29040285
C1_02519	AE004911_8	53.7	410	1	189	5	413	5	414	1.56e-144	417.0	Q9HUH7	PHI:7635	waaA	287	nan	Pseudomonas aeruginosa	PAO1	infection	Eudicots_Rodents	4236_10090	Lactuca sativa (related: garden lettuce)_Mus musculus (related: house mouse)	3-deoxy-D-manno-octulosonic-acid (KDO) transferase	reduced virulence_unaffected pathogenicity	Gene deletion: full	29045498
C1_02521	AAL22581	89.6	374	0	39	1	374	1	374	7.85e-252	684.0	H9L435	PHI:9593	rfaG	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain LT2	salmonellosis	Even-toed ungulates	9823	Sus scrofa (related: pig)	Glucosyltransferase I	reduced virulence	Gene mutation	31540295
C1_02530	AAA24524	93.6	419	0	27	1	419	1	419	6.02e-265	721.0	P27243	PHI:9414_PHI:3106	waaL_rfaL (ocw)	562	nan	Escherichia coli	RS218_DE17	bacterial sepsis; neonatal meningitis_avian colibacillosis	Birds_Primates_Rodents	8839_10090_9606	Homo sapiens (related: human)_Anas platyrhynchos (related: mallard)_Mus musculus (related: house mouse)	O antigen ligase_encodes O-antigen ligase	reduced virulence	Gene deletion: full; gene complementation_Gene disruption; gene complementation	24970366_31400443
C1_02531	AAL22571	83.5	316	0	52	1	316	1	316	3.3800000000000007e-195	536.0	P26469	PHI:9594	rfaC	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain LT2	salmonellosis	Even-toed ungulates	9823	Sus scrofa (related: pig)	heptosyl transferase	reduced virulence	Gene mutation	31540295
C1_02536	ABF06562_ABP89539	42.0	112	0	65	7	118	3	114	3.9e-23	96.7	A4VTV0	PHI:4130_PHI:6140	cps2J	1307	nan	Streptococcus suis	SC19_serotype 2 strain 89/1591	meningitis; septicemia; arthritis; pneumonia (pig)_meningitis	Lethal pathogen phenotype_Rodents	Lethal pathogen phenotype_10090	Lethal pathogen phenotype_Mus musculus (related: house mouse)	Glycosyltransferases_genes involved in side-chain formation	reduced virulence_lethal	Gene mutation	24654559_26946377
C1_02538	ALE64165	89.7	417	0	43	3	419	11	427	1.46e-223	617.0	A0A0D6I3U0	PHI:5573	envC	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Determinants for intrinsic CAMP resistance	reduced virulence	Gene mutation	26810659
C1_02539	CAL18753	83.5	515	1	84	1	514	1	515	6.37e-313	851.0	Q8ZJN0	PHI:11412	pgm	632	nan	Yersinia pestis	KIM5_CO92	plague	Rodents	10090	Mus musculus (related: house mouse)	2,3-Bisphosphoglycerate-independent phosphoglycerate mutase	reduced virulence_increased virulence (hypervirulence)	Gene deletion: full; gene complementation	31907194
C1_02549	ABN73547	42.0	138	1	69	1479	1616	3221	3347	6.87e-19	92.4	A3MZG1	PHI:5230_PHI:4673	Apa1	715	PHI:5231_nan	Actinobacillus pleuropneumoniae	serotype 5b strain L20	pleuropneumonia (pig)	Even-toed ungulates_Rodents	9823_10090	Sus scrofa (related: pig)_Mus musculus (related: house mouse)	Trimeric autotransporter_Autotransporter adhesin	reduced virulence	Gene mutation_Gene mutation; gene complementation	26494209_25818350
C1_02564	ACO02727	56.9	341	2	145	1	341	1	339	1.7000000000000002e-133	382.0	C0RM94	PHI:11546	B0934	29459	nan	Brucella melitensis	M28	brucellosis	Rodents	10090	Mus musculus (related: house mouse)	MetQ/NlpA family ABC transporter substrate-binding protein	unaffected pathogenicity	Gene deletion: full; gene complementation	32778612
C1_02567	AAM40737	42.5	1044	12	574	2	1030	4	1036	1.41e-251	736.0	Q8PAN9	PHI:123430	saxF (XCC1440)	339	PHI:123429	Xanthomonas campestris	pv. campestris strain Xc1	black rot	Eudicots	3712	Brassica oleracea (no common name found)	Efflux pump membrane transporter	reduced virulence	Gene mutation	35942507
C1_02571	ATX61795	41.0	83	1	38	198	280	517	588	1.19e-07	51.2	A0A2H4QBA5	PHI:10188	modK1	504	nan	Kingella kingae	KK003	skeletal disease (children); infective endocarditis	Primates	9606	Homo sapiens (related: human)	Adenine specific DNA methylase	reduced virulence	Gene mutation	28947652
C1_02572	ACT11296	98.0	98	0	2	1	98	1	98	6.21e-63	184.0	C6DIJ6	PHI:10577	PccS1_001523	554	nan	Pectobacterium carotovorum	subsp. carotovorum strain PccS1	soft rot	Monocots	69721	Zantedeschia aethiopica (related: arum-lily)	Transcriptional regulator, Fis family, Fis	unaffected pathogenicity	Gene deletion: full; gene complementation	32267092
C1_02585	CAG62563	41.2	439	4	251	5	440	633	1067	2.14e-107	347.0	Q6FJK7	PHI:123297	DUR1,2	5476	nan	Candida albicans	nan	disseminated candidiasis	Rodents	10090	Mus musculus (related: house mouse)	urea amidolyase	reduced virulence	Gene deletion: full; gene complementation	35795910
C1_02586	AAX97431	45.9	61	0	33	95	155	72	132	2.33e-08	48.5	Q2KKC1	PHI:8542	OadD	1351	nan	Enterococcus faecalis	JH2-2	nosocomial infection	Primates_Moths_Rodents	7137_10090_9606	Homo sapiens (related: human)_Galleria mellonella (related: greater wax moth)_Mus musculus (related: house mouse)	Biotin acceptor protein	reduced virulence	Gene deletion: full	30335810
C1_02596	AAY48578	62.6	479	1	175	2	480	5	479	2.85e-205	575.0	Q4UWJ5	PHI:3952	XC_1510	339	nan	Xanthomonas campestris	pv. campestris strain 8004	black rot	Eudicots	3726	Raphanus sativus (related: radish)	TldD protein, DNA gyrase control?	reduced virulence	Gene mutation	23819805
C1_02604	ACR67684	83.0	312	0	53	1	312	1	312	2.19e-181	501.0	C5BF98	PHI:2959	mdh	67780	nan	Edwardsiella ictaluri	93-146	enteric septicemia	Bony fishes	7998	Ictalurus punctatus (related: channel catfish)	Malate dehydrogenase	reduced virulence	Gene deletion: partial	23762452
C1_02606	ADM96537	70.0	457	2	134	1	455	1	456	2.15e-218	607.0	E0SHD8	PHI:8575	degQ (Dda3937_00697)	204038	nan	Dickeya dadantii	3937	soft rot	Eudicots	13427	Cichorium intybus (related: chicory)	Protease	reduced virulence	Gene deletion: full	30267562
C1_02629	AAY48376	48.4	273	4	131	4	269	1	270	2.01e-86	258.0	Q4UX47	PHI:7824	HpaP (XC_1307)	339	nan	Xanthomonas campestris	pv. campestris strain 8004	black rot	Eudicots	3712_4072	Brassica oleracea (no common name found)_Capsicum annuum (no common name found)	Regulatory protein with ATPase and phosphatase activity	reduced virulence	Gene deletion: full; gene complementation	29345052
C1_02630	CAH22766	86.2	152	0	21	4	155	3	154	4.13e-89	255.0	Q665I9	PHI:3133	ptsN	633	nan	Yersinia pseudotuberculosis	YPIII	gut-associated disease; diarrhea; enteritis; colitis	Rodents	10090	Mus musculus (related: house mouse)	Part of the pyruvate - tricarboxylic acid cycle node	reduced virulence	Gene disruption	25164818
C1_02631	CBA19257	82.1	95	0	17	1	95	1	95	2.04e-53	160.0	D4HUY4	PHI:3674_PHI:3680	yhbH	552	nan	Erwinia amylovora	Ea1189	fire blight	Eudicots	3750_23211	Malus domestica (related: apple)_Pyrus communis (related: pear)	a novel ribosome-associated modulation protein	loss of pathogenicity	Gene mutation; gene complementation	23937726
C1_02632	CBA19258	76.3	477	0	113	1	477	1	477	8.36e-248	683.0	D4HUY5	PHI:3673_PHI:3679_PHI:2906	rpoN	552	nan	Erwinia amylovora	HKN06P1_Ea1189	fire blight	Eudicots	3750_23211	Malus domestica (related: apple)_Pyrus communis (related: pear)	Sigma factor, regulating essential virulence gene expression_a nitrogen limitation sigma factor	loss of pathogenicity	Gene mutation_Gene mutation; gene complementation	23721085_23937726
C1_02637	YP_169795	54.3	311	3	137	18	324	14	323	1.03e-108	318.0	Q5NGP7	PHI:7067	KdsD	263	nan	Francisella tularensis	SCHU S4	tularemia	Rodents	10090	Mus musculus (related: house mouse)	D-arabinose 5-phosphate isomerase	reduced virulence	Gene disruption; gene complementation	28328947
C1_02645	AAG07838	60.1	421	2	165	1	418	1	421	1.7000000000000003e-173	490.0	Q9HVW7	PHI:7630	murA	287	nan	Pseudomonas aeruginosa	PAO1	infection	Eudicots_Rodents	4236_10090	Lactuca sativa (related: garden lettuce)_Mus musculus (related: house mouse)	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	reduced virulence_unaffected pathogenicity	Gene deletion: full	29045498
C1_02653	AAL22169	96.8	158	0	5	1	158	1	158	3.24e-107	301.0	P64281	PHI:7130	greA	28901	PHI:7131	Salmonella enterica	subsp. enterica serovar Typhimurium strain SV5015	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Transcription elongation factor	loss of pathogenicity	Gene mutation	28426789
C1_02656	CAE50533	46.4	610	8	301	6	595	5	608	1.6900000000000002e-166	495.0	Q6NF92	PHI:11203	ftsH	1717	nan	Corynebacterium diphtheriae	NCTC 13129	diphtheria	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	ATP-dependent zinc metalloprotease	unaffected pathogenicity	Altered gene expression / gene regulation: overexpression	33672886
C1_02670	AAL22154	97.2	711	0	20	1	711	1	711	0.0	1311.0	Q8ZLT3	PHI:3878	pnp	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain X4232	food poisoning	Even-toed ungulates	9823	Sus scrofa (related: pig)	polynucleotide phosphorylase, an exoribonuclease involved in RNA processing and degradation	reduced virulence	Gene mutation	24126127
C1_02671	EAM_3066	88.4	294	0	34	1	294	1	294	1.1e-188	518.0	D4ICB6	PHI:2459	nlpI	552	nan	Erwinia amylovora	Ea1189	fire blight	Eudicots	23211	Pyrus communis (related: pear)	Tetratricopeptide lipoprotein	reduced virulence	Gene deletion: full; gene complementation	21831138
C1_02672	CAC98944	43.7	428	3	231	6	431	2	421	2.54e-111	342.0	Q8Y8N0	PHI:7620_PHI:6510	Lmo0866_CshA	1639	PHI:7617; PHI:7618; PHI:7619_nan	Listeria monocytogenes	EGD-e	listeriosis	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	RNA Helicase_DExD-box RNA-helicase	unaffected pathogenicity_increased virulence (hypervirulence)	Gene deletion: full_Gene deletion: full; gene complementation_Gene mutation; gene complementation	25590644_26483402
C1_02676	ARA47379	97.6	331	0	8	1	331	1	331	5.49e-244	661.0	A0A0W8AWM7	PHI:11411	yhbU	573	nan	Klebsiella pneumoniae	ATCC 43816; MKP203	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Ubiquinone biosynthesis protein	unaffected pathogenicity	Gene deletion: full; gene complementation	31988174
C1_02688	BAB41677	48.9	227	1	115	14	240	4	229	4.23e-61	193.0	A0A0H3JLK2	PHI:4960	rsmI	1280	nan	Staphylococcus aureus	RN4220	skin infection; food poisoning; respiratory disease	Moths	7091	Bombyx mori (related: domestic silkworm)	Ribosomal RNA small subunit methyltransferase I	reduced virulence	Gene deletion: full; gene complementation	25893373
C1_02714	CBA23513	84.5	309	0	48	1	309	1	309	1.85e-199	546.0	D4I2T4	PHI:9313	metA	552	nan	Erwinia amylovora	HKN06P1	fire blight	Eudicots	3750	Malus domestica (related: apple)	Homoserine O-succinyltransferase	reduced virulence	Gene mutation	31152019
C1_02715	EGX45923	49.9	509	8	243	22	525	22	523	7.92e-163	472.0	G1XLT2	PHI:4021	AoMls	2813651	nan	Orbilia oligospora	CBS 115.81	nematode trapping fungus	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	Malate synthase	reduced virulence	Gene deletion: full	24323290
C1_02730	CBA23505	83.6	548	1	89	1	548	1	547	0.0	949.0	D4I2T0	PHI:9310	pgi	552	nan	Erwinia amylovora	HKN06P1	fire blight	Eudicots	3750	Malus domestica (related: apple)	Glucose-6-phosphate isomerase	reduced virulence	Gene mutation	31152019
C1_02757	ACY91441	90.0	60	0	6	1	60	1	60	9.82e-27	91.7	A0A0F6BA89	PHI:7661	pspG	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ST4/74	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Phage-shock protein	unaffected pathogenicity	Gene mutation; gene complementation	24713356
C1_02760	ABK38597	56.8	359	1	154	1	359	1	358	1.03e-141	405.0	A0KL98	PHI:11459	alr-2	644	nan	Aeromonas hydrophila	HBNUAh01	diarrhea; nausea; vomiting	Bony fishes_Rodents	7962_10090	Mus musculus (related: house mouse)_Cyprinus carpio (related: common carp)	Alanine racemase	reduced virulence	Gene deletion: full; gene complementation	30940083
C1_02767	AAW74693	56.1	114	2	46	3	116	2	111	2.04e-39	130.0	Q5H2X8	PHI:2737	SSBX	347	PHI:2738_nan	Xanthomonas oryzae	pv. oryzicola strain RS105	leaf blight	Monocots	4530	Oryza sativa (related: rice)	Single-stranded DNA-binding protein	reduced virulence	Gene deletion: full_Gene deletion: full; gene complementation	23418541
C1_02770	AIK80589	49.0	100	0	51	5	104	6	105	2.52e-33	110.0	Q48413	PHI:7475	ramA (VK055_1983)	573	PHI:7488; PHI:7489; PHI:7490; PHI:7476; PHI:7477; PHI:7491; PHI:7492; PHI:7493; PHI:7494; PHI:7495; PHI:7496; PHI:7497; PHI:7498; PHI:7499; PHI:7500; PHI:7501; PHI:7502; PHI:7503; PHI:7504; PHI:7505; PHI:7506; PHI:7507; PHI:7508; PHI:7509; PHI:7510; PHI:7511; PHI:7512_PHI:7476; PHI:7477_nan	Klebsiella pneumoniae	KPPR1	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Bacterial regulatory helix-turn-helix, AraC family protein	unaffected pathogenicity	Gene deletion: full	28861522
C1_02771	EHT98350	69.7	145	0	44	9	153	9	153	6.880000000000001e-72	211.0	H3RJ93	PHI:3091	OxyR	66269	nan	Pantoea stewartii	subsp. stewartii strain DC283	stewart's wilt	Monocots	4577	Zea mays (related: maize)	activate gene expression in response to oxidative stress	unaffected pathogenicity	Gene mutation	24450773
C1_02775	AAC77037	99.8	549	0	1	1	549	1	549	0.0	1028.0	P32705	PHI:9229	actP	562	PHI:9227; PHI:9228_nan	Escherichia coli	FY26	avian colisepticemia	Birds_Rodents	9031_10090_8839	Gallus gallus (related: chicken)_Anas platyrhynchos (related: mallard)_Mus musculus (related: house mouse)	Acetate/glycolate:cation symporter	reduced virulence_unaffected pathogenicity	Gene mutation; gene complementation	31046828
C1_02776	AAC77038	100.0	104	0	0	1	104	1	104	9.58e-72	207.0	P0AF54	PHI:9228	yjcH	562	PHI:9227; PHI:9229	Escherichia coli	FY26	avian colisepticemia	Birds_Rodents	9031_10090_8839	Gallus gallus (related: chicken)_Anas platyrhynchos (related: mallard)_Mus musculus (related: house mouse)	Conserved inner membrane protein	reduced virulence_unaffected pathogenicity	Gene mutation; gene complementation	31046828
C1_02777	AAC43163	100.0	652	0	0	1	652	1	652	0.0	1347.0	P27550	PHI:9227	acs	562	nan_PHI:9228; PHI:9229	Escherichia coli	FY26	avian colisepticemia	Birds_Rodents	9031_10090_8839	Gallus gallus (related: chicken)_Anas platyrhynchos (related: mallard)_Mus musculus (related: house mouse)	Acetyl-coenzyme A synthetase	reduced virulence_unaffected pathogenicity	Gene mutation; gene complementation	31046828
C1_02780	AAC77042	100.0	223	0	0	1	223	1	223	3.7e-172	470.0	P0AAK7	PHI:10999	nrfC	562	nan	Escherichia coli	PCN033	infection	Rodents	10090	Mus musculus (related: house mouse)	Putative menaquinol-cytochrome c reductase 4Fe-4S subunit	unaffected pathogenicity	Gene deletion: full	32962530
C1_02793	AGT97036	40.1	633	5	368	32	661	43	667	1.2e-161	479.0	U3M7S2	PHI:3268	YraS	29486	nan	Yersinia ruckeri	150	enteric redmouth disease	Bony fishes	8022	Oncorhynchus mykiss (related: rainbow trout)	Heat sensitive alkyl sulphatase	unaffected pathogenicity	Gene mutation: characterised; gene complementation	25266819
C1_02817	AAA72365	90.5	222	0	21	1	222	1	222	2.34e-145	402.0	P36556	PHI:4497	PmrA	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	lipopolysaccharide modification regulator	increased virulence (hypervirulence)	Gene mutation	23690578
C1_02818	AUV50255	40.7	496	3	289	52	545	65	557	4.5e-143	422.0	A0A2R2ZJD0	PHI:11670	mcr-3	562	nan	Escherichia coli	SHP45	infection	Moths_Primates	7137_9606	Homo sapiens (related: human)_Galleria mellonella (related: greater wax moth)	Phosphoethanolamine--lipid A transferase 	increased virulence (hypervirulence)	Altered gene expression / gene regulation: overexpression	34356793
C1_02826	AAL23124	93.1	548	0	38	1	548	1	548	0.0	1038.0	Q8ZKE2	PHI:10047	fumB	28901	PHI:10046; PHI:10048; PHI:10051_PHI:10046; PHI:10048; PHI:10050_PHI:10046; PHI:10048_PHI:10046; PHI:10048; PHI:10049_PHI:10046; PHI:10048; PHI:10051; PHI:10050_PHI:10046; PHI:10048; PHI:10051; PHI:10049	Salmonella enterica	subsp. enterica serovar Typhimurium strain NCTC 12023	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Fumarate hydratase class I	reduced virulence	Gene mutation; gene complementation	31826974
C1_02829	ADE34180	40.0	70	1	36	472	535	829	898	4.21e-06	48.1	D5LHI2	PHI:8857	slnCl1 (GU907087)	290576	nan	Colletotrichum lindemuthianum	89 A2 2-3	anthracnose	Eudicots	3885	Phaseolus vulgaris (related: kidney bean)	Histidine kinase class IV	reduced virulence	Altered gene expression / gene regulation: silencing	30642461
C1_02833	EJP68141	40.5	499	7	273	29	504	95	592	8.45e-113	344.0	J5K1T7	PHI:9409	Krs (BBA_03037)	176275	nan	Beauveria bassiana	ARSEF 2860	white muscardine	Moths	7137	Galleria mellonella (related: greater wax moth)	Lysine-tRNA synthetase	reduced virulence	Gene deletion: full; gene complementation	29029702
C1_02836	PEH73496	83.6	439	0	72	1	439	1	439	1.5199999999999996e-268	733.0	A0A2A7U510	PHI:11871	cadB	636	PHI:11872_nan_PHI:11870	Edwardsiella tarda	TX01	edwardsiellosis	Rodents_Bony fishes_Primates	8128_10090_9606	Homo sapiens (related: human)_Oreochromis niloticus (related: nile tilapia)_Mus musculus (related: house mouse)	Lysine-dependent acid resistance (LDAR) system protein_Lysine-dependent acid resistance (LDAR) system membrane protein	reduced virulence_unaffected pathogenicity	Gene deletion: full; gene complementation	34521475
C1_02837	ACY83600	49.5	551	6	236	1	512	1	548	6.03e-175	502.0	D0ZCW9	PHI:11872	cadC	636	PHI:11871_PHI:11870	Edwardsiella tarda	TX01	edwardsiellosis	Primates	9606	Homo sapiens (related: human)	Lysine-dependent acid resistance (LDAR) system membrane protein	unaffected pathogenicity	Gene deletion: full; gene complementation	34521475
C1_02847	BAA04222	62.2	529	1	199	3	530	2	530	1.9199999999999998e-219	617.0	P42375	PHI:3085	GroEL	837	nan	Porphyromonas gingivalis	ATCC 33277	periodontitis	Rodents	10114	Rattus (related: rat)	folding of newly synthesized proteins, preventing misfolding and aggregation	increased virulence (hypervirulence)	Functional test in host: direct injection	25058444
C1_02849	CAJ12598	50.4	131	1	64	1	130	1	131	4.79e-44	139.0	Q2YJ35	PHI:9061	nikR (bab2_0432)	235	nan	Brucella abortus	2308	ovine brucellosis	Rodents	10090	Mus musculus (related: house mouse)	Nickel-responsive regulator	unaffected pathogenicity	Gene mutation	30062985
C1_02850	ACO02585	53.3	261	0	122	1	261	1	261	5.079999999999999e-89	263.0	C0RLV2	PHI:11545	B0779	29459	nan	Brucella melitensis	M28	brucellosis	Rodents	10090	Mus musculus (related: house mouse)	ABC transporter substrate-binding protein	unaffected pathogenicity	Gene deletion: full; gene complementation	32778612
C1_02851	AAP56864	41.0	122	0	72	122	243	208	329	1.16e-24	100.0	Q7NAX1	PHI:7715	MGA_0220	2096	nan	Mycoplasma gallisepticum	Ap3AS	airsacculitis	Birds	9031	Gallus gallus (related: chicken)	Oligopeptide transporter ATP-binding protein OppD1	reduced virulence	Gene deletion: full; gene complementation	28348054
C1_02854	CAR45801	44.2	520	3	287	2	520	4	521	1.42e-154	450.0	B4EZP9	PHI:123443	nikA	584	PHI:123444_PHI:123442_nan	Proteus mirabilis	HI4320	catheter-associated urinary tract infection	Rodents	10090	Mus musculus (related: house mouse)	ABC transporter. substrate-binding protein	reduced virulence_unaffected pathogenicity	Gene deletion: full	32255226
C1_02861	EFE21438	64.5	691	3	236	49	732	45	733	1.27e-287	805.0	D4F9X0	PHI:11870	cadA	636	PHI:11871_PHI:11872_nan	Edwardsiella tarda	TX01	edwardsiellosis	Rodents_Bony fishes_Primates	8128_10090_9606	Homo sapiens (related: human)_Oreochromis niloticus (related: nile tilapia)_Mus musculus (related: house mouse)	Lysine-dependent acid resistance (LDAR) system protein	reduced virulence_unaffected pathogenicity	Gene deletion: full; gene complementation	34521475
C1_02885	ADI35182	52.5	537	5	248	41	571	29	564	6.92e-191	546.0	D6XQY8	PHI:7689	gGT	210	nan	Helicobacter pylori	PMSS1	gastric infection	Rodents	10090	Mus musculus (related: house mouse)	γ-Glutamyl transferase	reduced virulence	Gene mutation; gene complementation	29057967
C1_02894	CSB09787	45.6	90	1	48	84	173	1	89	4.87e-23	86.3	A0A0H6FRN3	PHI:6701	gntK	666	nan	Vibrio cholerae	serotype O1 biovar El Tor strain N16961	cholera	 hares_Rabbits _Rodents	10090_9986	Oryctolagus cuniculus (related: rabbit)_Mus musculus (related: house mouse)	Thermo-resistant gluconate kinase	reduced virulence	Gene mutation; gene complementation	27650573
C1_02901	AAL22395	94.3	477	0	27	1	477	1	477	0.0	919.0	P05416	PHI:10051	glgA	28901	PHI:10046; PHI:10047; PHI:10048; PHI:10049_PHI:10046; PHI:10047; PHI:10048; PHI:10050_PHI:10046; PHI:10047; PHI:10048	Salmonella enterica	subsp. enterica serovar Typhimurium strain NCTC 12023	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Glycogen synthase	reduced virulence	Gene mutation; gene complementation	31826974
C1_02902	XP_363893_EHA55026	48.4	820	9	407	8	815	71	886	1.84e-266	760.0	G4MW66	PHI:3815_PHI:2062	Gph1_GPH1	318829	PHI:2061_PHI:3814_nan	Magnaporthe oryzae	B157_Guy11	blast (rice)	Monocots	4530_4513	Oryza sativa (related: rice)_Hordeum vulgare (related: barley)	Phosphorylase_nan	loss of pathogenicity_reduced virulence_unaffected pathogenicity	Gene deletion: full_Gene disruption	19115483_24098112
C1_02907	AE013994_1	77.4	504	1	111	1	501	29	532	2.56e-292	799.0	Q8CWG4	PHI:3272	glpD	632	nan	Yersinia pestis	CO92	pneumonic plague	Rodents	10090	Mus musculus (related: house mouse)	Glycerol-3-phosphate dehydrogenase involved in glycerol fermentation	unaffected pathogenicity	Gene deletion: full; gene complementation	25220241
C1_02914	CCP43592	50.9	57	0	28	836	892	155	211	1.33e-08	54.7	P9WGM5	PHI:3620	narL	1773	nan	Mycobacterium tuberculosis	H37Rv	tuberculosis	Rodents	10090	Mus musculus (related: house mouse)	Two-Component Regulatory Systems	unaffected pathogenicity	Gene mutation	12595424
C1_02923	CRQ13186	67.2	744	2	240	1	743	1	741	0.0	958.0	A0A0F6UGK4	PHI:6941	feoB	287	PHI:6941_nan	Pseudomonas aeruginosa	PAO1	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Ferrous iron transport protein	loss of pathogenicity_increased virulence (hypervirulence)	Gene mutation; gene complementation	27271740
C1_02926	AAL22365	94.9	157	0	8	1	157	1	157	1.09e-107	302.0	Q8ZLJ2	PHI:7131	greB	28901	PHI:7130	Salmonella enterica	subsp. enterica serovar Typhimurium strain SV5015	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Transcription elongation factor	loss of pathogenicity	Gene mutation	28426789
C1_02927	OMPR_SALTY	100.0	239	0	0	1	239	1	239	3.13e-172	472.0	P0AA19	PHI:2685	ompR	28901	PHI:2686	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028s	food poisoning	Rodents	10090	Mus musculus (related: house mouse)	Regulators of systemic infection	reduced virulence	Gene deletion: full; gene complementation	19229334
C1_02928	ENVZ_SALTY	95.8	449	0	19	1	449	1	449	2.48e-314	849.0	P08982	PHI:2686	envZ	28901	PHI:2685	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028s	food poisoning	Rodents	10090	Mus musculus (related: house mouse)	Regulators of systemic infection	reduced virulence	Gene deletion: full; gene complementation	19229334
C1_02931	EAL19243	46.9	503	9	251	45	538	53	548	1.82e-141	418.0	F5HAA8	PHI:424	PCK1	5207	nan	Cryptococcus neoformans	H99	cryptococcosis	Rodents	10090	Mus musculus (related: house mouse)	Phosphoenolpyruvate carboxykinase	reduced virulence	Gene deletion; gene complementation	15765146
C1_02937	AE004930_7	47.3	182	2	93	6	184	3	184	2.7999999999999996e-54	169.0	Q9HU13	PHI:10783	PA5176	287	nan	Pseudomonas aeruginosa	PAO1161	infection	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	Nudix hydrolase domain-containing protein	reduced virulence	Gene deletion: full; gene complementation	32419387
C1_02945	ACR27505	58.3	345	1	143	1	345	1	344	6.829999999999999e-131	377.0	C5A9K4	PHI:4250	aroB	337	nan	Burkholderia glumae	411gr-6	panicle blight	Monocots	4530	Oryza sativa (related: rice)	3-dehydroquinate synthase	reduced virulence	Gene mutation	24754446
C1_02946	CAA33253	97.0	428	0	13	1	428	1	428	6.8e-220	608.0	P11557	PHI:6729	damX	562	nan	Escherichia coli	UTI89	urinary tract infection	Rodents	10090	Mus musculus (related: house mouse)	Cell division protein	reduced virulence	Gene mutation	27486187
C1_02966	AAC76392_CAA32418	100.0	268	0	0	1	268	1	268	5.25e-199	542.0	P0AC26	PHI:3597_PHI:11706	NirC_nirC	562	nan	Escherichia coli	APEC strain SCI-07_APEC XM	infection_colibacillosis	Birds_Rodents	9031_10090	Gallus gallus (related: chicken)_Mus musculus (related: house mouse)	Nitrite transporter	reduced virulence	Gene deletion: full; gene complementation_Gene mutation; gene complementation	34091701_25487442
C1_02970	ALD83590	95.8	190	0	8	1	190	1	190	2.4300000000000003e-129	359.0	A0A0D6I7L0	PHI:11417	ppiA	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Peptidyl-prolyl cis-trans isomerase	reduced virulence	Gene deletion: full	31111418
C1_02973	AAY47562	60.4	192	1	71	1	187	1	192	3.1299999999999997e-81	238.0	Q4UZG1	PHI:3941	XC_0481	339	nan	Xanthomonas campestris	pv. campestris strain 8004	black rot	Eudicots	3726	Raphanus sativus (related: radish)	Anthranilate synthase component II	reduced virulence	Gene mutation	23819805
C1_02974	ACH49836	91.3	404	0	35	1	404	1	404	1.18e-278	755.0	B5F8I0	PHI:8863	ArgD	28901	PHI:8862_PHI:8860; PHI:8861; PHI:8862	Salmonella enterica	subsp. enterica serovar Agona strain Ag 1	infection	Rodents	10090	Mus musculus (related: house mouse)	Acetylornithine/succinyldiaminopimelate aminotransferase	reduced virulence	Gene mutation	30671294
C1_02976	CRP_SALTY	99.5	210	0	1	1	210	1	210	2.14e-151	417.0	P0A2T6	PHI:2684	crp	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028s	food poisoning	Rodents	10090	Mus musculus (related: house mouse)	Regulators of systemic infection	reduced virulence	Gene deletion: full; gene complementation	19229334
C1_02987	CBA34185	83.9	273	2	40	1	269	1	273	6.68e-147	410.0	C9Y236	PHI:4583	FkpA	413502	nan	Cronobacter turicensis	LMG 23827	meningitis; bacteremia	Primates	9606	Homo sapiens (related: human)	virulence factor	reduced virulence	Gene mutation; gene complementation	25724920
C1_02992	FGSG_09662	58.4	125	2	49	2	123	53	177	2.46e-42	136.0	I1RZ39	PHI:1599	GzOB039	5518	nan	Fusarium graminearum	GZ3639	fusarium ear blight	Monocots	4564	Triticum (related: wheat)	transcription factor	unaffected pathogenicity	Gene deletion	22028654
C1_02999	EHA52051	61.7	366	1	138	4	367	11	376	1.43e-166	469.0	G4N4N6	PHI:4616	MoSFA1	318829	nan	Magnaporthe oryzae	Guy11	blast (rice)	Monocots	4530	Oryza sativa (related: rice)	S-(Hydroxymethyl)Glutathione Dehydrogenase	reduced virulence	Gene deletion: full; gene complementation	25793615
C1_03011	AAA24053	98.7	1024	0	13	1	1024	1	1024	0.0	2132.0	P00722	PHI:6268_PHI:9897	lacZ	562	nan	Escherichia coli	RS218_UTI89	urinary tract infection	Rodents	10090	Mus musculus (related: house mouse)	Beta-galactosidase	reduced virulence_unaffected pathogenicity	Gene mutation_Gene mutation; gene complementation	27073089_31900139
C1_03014	FGSG_07458	43.4	136	1	76	22	156	29	164	3.23e-26	95.9	I1RTF5	PHI:1532	GzLam001	5518	nan	Fusarium graminearum	GZ3639	fusarium ear blight	Monocots	4564	Triticum (related: wheat)	transcription factor	unaffected pathogenicity	Gene deletion	22028654
C1_03015	AE004449_1	47.3	207	2	100	1	202	22	224	2.3e-61	190.0	Q9I730	PHI:9599	psCA1	287	nan	Pseudomonas aeruginosa	PAO1	nosocomial infection	Moths	7137	Galleria mellonella (related: greater wax moth)	β-Carbonic anhydrase	reduced virulence	Gene deletion: full	31589941
C1_03034	AAC73427	98.7	460	0	6	1	460	1	460	0.0	904.0	P77554	PHI:10984	yahJ	562	nan	Escherichia coli	PCN033	infection	Rodents	10090	Mus musculus (related: house mouse)	Putative deaminase with metallo-dependent hydrolase domain	reduced virulence	Gene deletion: full	32962530
C1_03043	CAC05837_YP_009078435	44.4	520	4	276	814	1327	590	1102	1.35e-117	393.0	Q7BCK4	PHI:9890_PHI:4647	IcsA	623	nan	Shigella flexneri	serotype 2a strain 301_M90T	shigellosis	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Outer membrane protein IcsA autotransporter_Adhesin Regulated by the Type III Secretion System	reduced virulence	Gene disruption_Gene mutation	24721572_29858013
C1_03045	AIK80557	93.3	193	0	13	1	193	1	193	5.65e-126	351.0	B5Y006	PHI:7521	BetI (VK055_1951)	573	PHI:7513; PHI:7514; PHI:7515; PHI:7516; PHI:7517; PHI:7518; PHI:7519; PHI:7520; PHI:7522; PHI:7523; PHI:7524; PHI:7525; PHI:7526; PHI:7527; PHI:7528; PHI:7529; PHI:7530; PHI:7531; PHI:7532; PHI:7533; PHI:7534; PHI:7535; PHI:7536; PHI:7537; PHI:7538	Klebsiella pneumoniae	KPPR1	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Transcriptional repressor	unaffected pathogenicity	Gene deletion: full	28861522
C1_03046	AIK80558	89.3	487	0	52	4	490	1	487	9.4e-318	861.0	A0A076ZMY5	PHI:7520	VK055_1952	573	PHI:7513; PHI:7514; PHI:7515; PHI:7516; PHI:7517; PHI:7518; PHI:7519; PHI:7521; PHI:7522; PHI:7523; PHI:7524; PHI:7525; PHI:7526; PHI:7527; PHI:7528; PHI:7529; PHI:7530; PHI:7531; PHI:7532; PHI:7533; PHI:7534; PHI:7535; PHI:7536; PHI:7537; PHI:7538	Klebsiella pneumoniae	KPPR1	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Betaine aldehyde dehydrogenase	unaffected pathogenicity	Gene deletion: full	28861522
C1_03047	CAJ12443	40.3	531	8	307	3	531	5	527	1.48e-112	343.0	Q2YIV2	PHI:9126	bab2_0277	235	nan	Brucella abortus	2308	brucellosis	Rodents	10090	Mus musculus (related: house mouse)	choline dehydrogenase	reduced virulence	Gene disruption; gene complementation	29632093
C1_03056	ACY85867	41.3	455	6	245	80	518	178	626	3.76e-102	342.0	D0ZEM2	PHI:3781	inv	636	nan	Edwardsiella tarda	H1	nan	Bony fishes	7955	Danio rerio (related: zebrafish)	required to initiate the internalization of a bacterium into the host organism	reduced virulence	Gene deletion; gene complementation	23600645
C1_03067	AIZ85831	99.6	229	0	1	1	229	1	229	1.23e-164	452.0	J7QMF7	PHI:10988	yagT	562	nan	Escherichia coli	PCN033	infection	Rodents	10090	Mus musculus (related: house mouse)	Aldehyde dehydrogenase iron-sulfur subunit	unaffected pathogenicity	Gene deletion: full	32962530
C1_03084	CAD16448	41.9	413	1	239	5	416	13	425	6.05e-108	323.0	Q8XVT6	PHI:123502	proA	305	nan	Ralstonia solanacearum	OE1-1	wilt	Eudicots	4097	Nicotiana tabacum (related: common tobacco)	Gamma-glutamyl phosphate reductase	reduced virulence	Gene deletion: full; gene complementation; gene mutation: characterised	36106083
C1_03100	AAO28954	52.9	68	0	32	1	68	1	68	2.59e-20	75.9	Q87CH2	PHI:6844	dinJ	2371	PHI:6845	Xylella fastidiosa	Stag's Leap	pierce's disease of grapes; citrus variegated chlorosis	Eudicots	29760	Vitis vinifera (related: wine grape)	antitoxin, DNA-damage-inducible protein	increased virulence (hypervirulence)	Gene mutation	27938243
C1_03106	ABI99722	100.0	148	0	0	1	148	10	157	2.33e-104	293.0	A1A7T3	PHI:2647	ivy	562	PHI:2646_nan	Escherichia coli	CH2	colibacillosis; cellulitis; swollen head syndrome	Birds	9031	Gallus gallus (related: chicken)	Lysozyme inhibitor	unaffected pathogenicity	Gene deletion: full; gene complementation	23049900
C1_03132	AAL19351	95.6	229	0	10	1	229	1	229	1.18e-162	447.0	Q7CR43	PHI:123534	phoB	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028s	gastroenteritis	Rodents	10090	Mus musculus (related: house mouse)	Transcriptional regulator	reduced virulence	Gene deletion: full	31610610
C1_03133	AAL19352	91.2	431	0	38	1	431	1	431	1.04e-294	798.0	Q8ZRE1	PHI:9434	phoR	28901	PHI:9435_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	gastroenteritis	Rodents	10090	Mus musculus (related: house mouse)	Histidine kinase	reduced virulence_increased virulence (hypervirulence)	Gene mutation: characterised	31346161
C1_03136	ABJ15692	42.5	80	1	44	177	254	15	94	9.51e-10	60.1	Q02LV5	PHI:2745	treY	287	PHI:2746	Pseudomonas aeruginosa	PA14	soft rot	Eudicots_Rodents_Nematodes_Flies	7227_6239_10090_3702	Arabidopsis thaliana (related: thale cress)_Caenorhabditis elegans (related: roundworm)_Drosophila melanogaster (related: fruit fly)_Mus musculus (related: house mouse)	Trehalose biosynthetic genes	reduced virulence_unaffected pathogenicity	Gene disruption	23505373
C1_03146	AAK33390	44.9	147	0	81	1	147	1	147	2.6300000000000003e-42	136.0	P67320	PHI:3464	nrdR	1314	PHI:3465_nan	Streptococcus pyogenes	1529	toxic shock syndrome	Rodents	10090	Mus musculus (related: house mouse)	regulator	reduced virulence_unaffected pathogenicity	Gene mutation; gene complementation	25469586
C1_03159	AAY50743	51.8	166	3	72	1	163	1	161	1.4100000000000002e-47	150.0	Q4UQD0	PHI:3259	XC_3703	339	PHI:3260_nan	Xanthomonas campestris	pv. campestris strain 8004	black rot	Eudicots	3726	Raphanus sativus (related: radish)	Cyclic di-GMP Effectors	reduced virulence_effector (plant avirulence determinant)	Gene deletion: full	25329577
C1_03167	BAF67201	50.9	623	6	296	29	647	28	644	2.8e-215	615.0	A6QFR9	PHI:4038	qoxB	1280	nan	Staphylococcus aureus	nan	skin infection; food poisoning; respiratory disease	Rodents	10090	Mus musculus (related: house mouse)	Terminal Oxidases	reduced virulence	Gene mutation	24302255
C1_03168	AAM36129	59.0	266	3	104	20	282	20	283	1.42e-111	324.0	Q8PN16	PHI:4147	XAC1258	346	nan	Xanthomonas citri	subsp. citri	canker (citrus)	Eudicots	2711	Citrus sinensis (related: sweet orange)	CyoA, cytochrome O ubiquinol oxidase	reduced virulence	Gene mutation	24676796
C1_03173	BAA94668	99.0	207	0	2	1	207	1	207	4.49e-147	405.0	P0A1D7	PHI:3040	ClpP	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain C5	food poisoning	Rodents	10090	Mus musculus (related: house mouse)	proteolytic component	reduced virulence	Gene deletion: full; gene complementation	23676436
C1_03174	AAM40281	76.2	416	2	95	1	413	1	415	6.79e-226	623.0	Q8PBY5	PHI:9833	clpX	339	nan	Xanthomonas campestris	pv. campestris strain Xc17	black rot	Eudicots	3712	Brassica oleracea (no common name found)	ATP-binding subunit of ATP-dependent Clp protease	reduced virulence	Gene mutation; gene complementation	31741013
C1_03175	ACY87051	99.4	784	0	5	1	784	1	784	0.0	1495.0	A0A0F6AXS9	PHI:8808	lon	28901	PHI:8807	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	salmonellosis	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	ATP-dependent protease	increased virulence (hypervirulence)	Gene mutation	30648612
C1_03176	AAM35959	68.9	90	0	28	1	90	1	90	1.78e-38	122.0	Q8NL12	PHI:8676	hupB (XAC1081)	346	nan	Xanthomonas citri	subsp. citri strain 306	canker (citrus)	Eudicots	2708	Citrus limon (related: lemon)	Histone-like protein	reduced virulence	Gene mutation; gene complementation	30537413
C1_03190	FGSG_01689	41.6	113	4	53	2	101	5	117	6.63e-18	71.6	I1RDI9	PHI:1634	GzWing006	5518	nan	Fusarium graminearum	GZ3639	fusarium ear blight	Monocots	4564	Triticum (related: wheat)	transcription factor	unaffected pathogenicity	Gene deletion	22028654
C1_03195	AAL19427	98.6	72	0	1	1	72	1	72	5.03e-48	144.0	Q7CR17	PHI:11219	hha	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain SB300	salmonellosis	Rodents_Primates	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Hemolysin expression-modulating protein	reduced virulence	Gene deletion: full; gene complementation	33651227
C1_03196	AKH06147	95.2	124	0	6	1	124	1	124	4.18e-89	252.0	A0A0F7J4C9	PHI:11220	tomB	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain SB300	salmonellosis	Rodents_Primates	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Hha toxicity attenuator	reduced virulence	Gene deletion: full; gene complementation	33651227
C1_03197	CBW16569	94.7	1048	0	56	1	1048	1	1048	0.0	1890.0	A0A0H3N916	PHI:7307	AcrB	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain SL1344	salmonellosis	Primates_Moths_Rodents	7137_10090_9606	Homo sapiens (related: human)_Galleria mellonella (related: greater wax moth)_Mus musculus (related: house mouse)	Efflux pump membrane transporter	reduced virulence	Gene deletion: full_Gene mutation	28720734
C1_03198	AAA74436	59.3	371	6	132	8	374	4	359	7.24e-133	384.0	P52477	PHI:11922	mexA	287	PHI:11923	Pseudomonas aeruginosa	PAO1	infection	Rodents	10090	Mus musculus (related: house mouse)	Multidrug resistance protein	unaffected pathogenicity	Gene deletion: full; gene complementation	34680745
C1_03201	CAG74082	66.7	48	0	16	1	48	1	48	7.97e-15	59.7	Q6D803	PHI:8933	rsmS (ECA1172)	29471	nan	Pectobacterium atrosepticum	SCRI 1043	soft rot (potato); blackleg disease (potato)	Eudicots	4113	Solanum tuberosum (related: potato)	Uncharacterized protein	increased virulence (hypervirulence)	Gene deletion: full	30872786
C1_03208	AAA23460	99.8	624	0	1	1	624	1	624	0.0	1216.0	P0A6Z3	PHI:6472	htpG	562	nan	Escherichia coli	SP15	diarrhea	Rodents	10117_10090	Rattus rattus (related: black rat)_Mus musculus (related: house mouse)	heat shock protein 90 chaperone	reduced virulence	Gene mutation	27412582
C1_03221	AAY49572	44.2	208	3	107	39	243	63	264	5.0699999999999996e-46	153.0	A0A0H2X8G8	PHI:7780	NlpD (XC_2522)	339	nan	Xanthomonas campestris	pv. campestris strain 8004	black rot	Eudicots	3726	Raphanus sativus (related: radish)	LytM family regulator	reduced virulence	Gene deletion: full; gene complementation	29240286
C1_03225	CAJ70142	42.6	324	5	169	270	589	271	581	1.34e-72	242.0	Q17ZY8	PHI:9139	PrdR	1496	nan	Clostridioides difficile	JIR8094	pseudomembranous colitis	Rodents	10036	Mesocricetus auratus (related: golden hamster)	Proline-responsive regulatory protein	increased virulence (hypervirulence)	Gene deletion: full; gene complementation	30882947
C1_03230	AAK76207	49.7	312	5	150	2	308	3	312	7.03e-94	279.0	Q97NA2	PHI:3475	arcC	1313	PHI:3473; PHI:3474; PHI:3476; PHI:3477	Streptococcus pneumoniae	serotype 4 strain TIGR4	pneumococcal pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Part of the arginine deiminase system	reduced virulence	Gene deletion: full; gene complementation	25538192
C1_03259	ACR70489	74.7	959	2	240	1	956	1	959	0.0	1436.0	C5BAT0	PHI:2961	gcvP	67780	nan	Edwardsiella ictaluri	93-146	enteric septicemia	Bony fishes	7998	Ictalurus punctatus (related: channel catfish)	Glycine dehydrogenase	reduced virulence	Gene deletion: partial	23762452
C1_03262	BAA14327	98.8	400	0	5	1	400	1	400	6.980000000000001e-291	785.0	P25535	PHI:7028	ubiI	562	nan	Escherichia coli	UTI89	urinary tract infection	Rodents	10090	Mus musculus (related: house mouse)	Aerobic ubiquinone-8 synthase	reduced virulence	Gene mutation; gene complementation	27161114
C1_03283	AE005523_3	99.3	143	0	1	1	143	1	143	1.6699999999999998e-104	293.0	A0A4V1DMY4	PHI:10953	lmiA (z4267)	562	nan	Escherichia coli	serotype O157:H7	infection	Rodents	10090	Mus musculus (related: house mouse)	DNA-binding protein	reduced virulence	Gene deletion: full; gene complementation	33173003
C1_03287	AAB64445	52.4	42	0	20	19	60	21	62	2.17e-08	51.2	Q44135	PHI:8050	cpxA	715	PHI:8051	Actinobacillus pleuropneumoniae	4074	pleuropneumonia (pig)	Rodents	10090	Mus musculus (related: house mouse)	Sensor histidine kinase	reduced virulence	Gene deletion: full; gene complementation	29662838
C1_03294	CAD20572	47.9	668	11	326	1	662	1	652	1.42e-196	568.0	Q8MPM3	PHI:8028	Tkt	5665	nan	Leishmania mexicana	M379	leishmaniasis	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Transketolase	loss of pathogenicity	Gene deletion: full; gene complementation	29554142
C1_03303	AAC75974	100.0	306	0	0	1	306	1	306	8.299999999999999e-231	625.0	P60651	PHI:9150	speB	562	PHI:9151	Escherichia coli	APEC serotype O83:H4 ST117	colibacillosis	Birds	9031	Gallus gallus (related: chicken)	Agmatinase	reduced virulence_unaffected pathogenicity	Gene mutation	29519523
C1_03307	MGG_00383	54.3	372	4	164	5	370	17	388	8.68e-136	392.0	G4NCL5	PHI:877	MGG_00383	318829	nan	Magnaporthe oryzae	KJ201	blast (rice)	Monocots	4530	Oryza sativa (related: rice)	Hypothetical protein	reduced virulence	Gene disruption	17353894
C1_03312	AE004478_1	65.1	312	0	109	2	313	3	314	5.03e-145	409.0	Q9I697	PHI:9281	gshB	287	PHI:9280_nan	Pseudomonas aeruginosa	PAO1	urinary tract infection	Rodents	10090	Mus musculus (related: house mouse)	Glutathione synthetase	reduced virulence	Gene deletion; gene complementation	31157178
C1_03316	AKA33019	62.2	225	0	85	1	225	1	225	2.11e-102	294.0	A0A090B8T6	PHI:10397	cusR (ABUW_3323)	470	nan	Acinetobacter baumannii	AB5075	nosocomial infection	Moths_Rodents	7137_10090	Galleria mellonella (related: greater wax moth)_Mus musculus (related: house mouse)	DNA-binding response regulator	reduced virulence	Gene mutation; gene complementation	32117089
C1_03326	AIK80582	69.5	370	0	113	1	370	1	370	7.880000000000001e-200	553.0	A0A086IIR8	PHI:7496	YbdK (VK055_1976)	573	PHI:7488; PHI:7489; PHI:7490; PHI:7476; PHI:7475; PHI:7477; PHI:7491; PHI:7492; PHI:7493; PHI:7494; PHI:7495; PHI:7497; PHI:7498; PHI:7499; PHI:7500; PHI:7501; PHI:7502; PHI:7503; PHI:7504; PHI:7505; PHI:7506; PHI:7507; PHI:7508; PHI:7509; PHI:7510; PHI:7511; PHI:7512	Klebsiella pneumoniae	KPPR1	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Gamma-glutamyl cysteine ligase	unaffected pathogenicity	Gene deletion: full	28861522
C1_03329	AIK80541	54.1	205	1	92	4	206	1	205	1.64e-71	214.0	B5XZZ0	PHI:7537	EntD (VK055_1935)	573	PHI:7513; PHI:7514; PHI:7515; PHI:7516; PHI:7517; PHI:7518; PHI:7519; PHI:7520; PHI:7521; PHI:7522; PHI:7523; PHI:7524; PHI:7525; PHI:7526; PHI:7527; PHI:7528; PHI:7529; PHI:7530; PHI:7531; PHI:7532; PHI:7533; PHI:7534; PHI:7535; PHI:7536; PHI:7538	Klebsiella pneumoniae	KPPR1	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	4'-Phosphopantetheinyl transferase superfamily protein	unaffected pathogenicity	Gene deletion: full	28861522
C1_03330	AIK80540	81.4	751	5	126	1	746	1	742	0.0	1233.0	W9B570	PHI:7538	FepA (VK055_1934)	573	PHI:7513; PHI:7514; PHI:7515; PHI:7516; PHI:7517; PHI:7518; PHI:7519; PHI:7520; PHI:7521; PHI:7522; PHI:7523; PHI:7524; PHI:7525; PHI:7526; PHI:7527; PHI:7528; PHI:7529; PHI:7530; PHI:7531; PHI:7532; PHI:7533; PHI:7534; PHI:7535; PHI:7536; PHI:7537	Klebsiella pneumoniae	KPPR1	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	TonB-dependent siderophore receptor family protein	unaffected pathogenicity	Gene deletion: full	28861522
C1_03331	AAA23757	98.5	400	0	6	1	400	1	400	2.23e-312	840.0	P13039	PHI:4859	Fes	562	PHI:4860; PHI:4861_nan_PHI:4860	Escherichia coli	serotype O78:K80:H9 strain χ7122	respiratory disease (poultry); systemic disease (poultry)	Birds	9031	Gallus gallus (related: chicken)	Catecholate siderophore esterases	reduced virulence_unaffected pathogenicity	Gene mutation; gene complementation	25982934
C1_03332	CBG75491	42.2	64	0	37	4	67	2	65	1.48e-17	67.8	C9Z1K8	PHI:11107	SCAB_85461	1930	PHI:11106; PHI:11105_PHI:11105	Streptomyces scabiei	87.22	common scab (potato)	Eudicots	4113	Solanum tuberosum (related: potato)	Putative MbtH homolog	reduced virulence	Gene deletion: full; gene complementation	31282068
C1_03333	AIK80537	77.8	1293	2	284	1	1291	1	1292	0.0	1996.0	B5XZY6	PHI:7540	EntF (VK055_1931)	573	PHI:7482; PHI:7539; PHI:7541; PHI:7542; PHI:7483; PHI:7481; PHI:7478; PHI:7487; PHI:7486; PHI:7479; PHI:7485; PHI:7484; PHI:7543; PHI:7544; PHI:7545; PHI:7546; PHI:7547; PHI:7548; PHI:7549; PHI:7550; PHI:7551; PHI:7552	Klebsiella pneumoniae	KPPR1	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Amino acid adenylation domain protein	reduced virulence	Gene deletion: full	28861522
C1_03334	AAL19540	73.2	373	1	99	1	373	1	372	5e-192	533.0	Q8ZR36	PHI:9093	fepE	28901	PHI:9092_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain IR715	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Ferric enterobactin (Enterochelin) transporter	reduced virulence	Gene mutation	29447698
C1_03335	AIK80536	88.6	263	0	30	1	263	1	263	9.04e-168	463.0	W9B5Y9	PHI:7541	FepC (VK055_1930)	573	PHI:7482; PHI:7539; PHI:7540; PHI:7542; PHI:7483; PHI:7481; PHI:7478; PHI:7487; PHI:7486; PHI:7479; PHI:7485; PHI:7484; PHI:7543; PHI:7544; PHI:7545; PHI:7546; PHI:7547; PHI:7548; PHI:7549; PHI:7550; PHI:7551; PHI:7552	Klebsiella pneumoniae	KPPR1	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Ferric vibriobactin ABC transporter, ATP-binding protein	reduced virulence	Gene deletion: full	28861522
C1_03336	AIK80535	82.7	330	0	57	1	330	1	330	6.32e-183	506.0	W9B576	PHI:7542	FepG (VK055_1929)	573	PHI:7482; PHI:7539; PHI:7540; PHI:7541; PHI:7483; PHI:7481; PHI:7478; PHI:7487; PHI:7486; PHI:7479; PHI:7485; PHI:7484; PHI:7543; PHI:7544; PHI:7545; PHI:7546; PHI:7547; PHI:7548; PHI:7549; PHI:7550; PHI:7551; PHI:7552	Klebsiella pneumoniae	KPPR1	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Ferric enterobactin transport system permease	reduced virulence	Gene deletion: full	28861522
C1_03337	AIK80534	85.9	333	0	47	1	333	1	333	2.07e-188	521.0	W9BNM7	PHI:7483	FepD (VK055_1928)	573	PHI:7482; PHI:7539; PHI:7540; PHI:7541; PHI:7542; PHI:7481; PHI:7478; PHI:7487; PHI:7486; PHI:7479; PHI:7485; PHI:7484; PHI:7543; PHI:7544; PHI:7545; PHI:7546; PHI:7547; PHI:7548; PHI:7549; PHI:7550; PHI:7551; PHI:7552_nan	Klebsiella pneumoniae	KPPR1	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Ferric enterobactin transport system permease	reduced virulence_unaffected pathogenicity	Gene deletion: full	28861522
C1_03338	AIK80533	100.0	416	0	0	1	416	1	416	1.44e-282	766.0	W1B397	PHI:7481	entS (VK055_1927)	573	PHI:7482; PHI:7539; PHI:7540; PHI:7541; PHI:7542; PHI:7483; PHI:7478; PHI:7487; PHI:7486; PHI:7479; PHI:7485; PHI:7484; PHI:7543; PHI:7544; PHI:7545; PHI:7546; PHI:7547; PHI:7548; PHI:7549; PHI:7550; PHI:7551; PHI:7552_nan	Klebsiella pneumoniae	KPPR1	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Enterobactin exporter	reduced virulence_unaffected pathogenicity	Gene deletion: full	28861522
C1_03339	AIK80532	84.7	307	1	46	13	318	12	318	7.57e-183	505.0	A0A060VFL5	PHI:7478	FepB (VK055_1926)	573	PHI:7482; PHI:7539; PHI:7540; PHI:7541; PHI:7542; PHI:7483; PHI:7481; PHI:7487; PHI:7486; PHI:7479; PHI:7485; PHI:7484; PHI:7543; PHI:7544; PHI:7545; PHI:7546; PHI:7547; PHI:7548; PHI:7549; PHI:7550; PHI:7551; PHI:7552_nan	Klebsiella pneumoniae	KPPR1	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	periplasmic enterobactin transporter	reduced virulence	Gene deletion: full	28861522
C1_03340	AIK80531	75.4	391	0	96	1	391	1	391	1.3900000000000001e-212	587.0	A0A085DFX7	PHI:7487	EntC (VK055_1925)	573	PHI:7482; PHI:7539; PHI:7540; PHI:7541; PHI:7542; PHI:7483; PHI:7481; PHI:7478; PHI:7486; PHI:7479; PHI:7485; PHI:7484; PHI:7543; PHI:7544; PHI:7545; PHI:7546; PHI:7547; PHI:7548; PHI:7549; PHI:7550; PHI:7551; PHI:7552_PHI:7484; PHI:7485; PHI:7479; PHI:7486	Klebsiella pneumoniae	KPPR1	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Isochorismate synthase	reduced virulence_unaffected pathogenicity	Gene deletion: full	28861522
C1_03341	AIK80530	81.3	529	0	99	3	531	2	530	0.0	879.0	W9B580	PHI:7486	entE (VK055_1924)	573	PHI:7484; PHI:7485; PHI:7479; PHI:7487_PHI:7482; PHI:7539; PHI:7540; PHI:7541; PHI:7542; PHI:7483; PHI:7481; PHI:7478; PHI:7487; PHI:7479; PHI:7485; PHI:7484; PHI:7543; PHI:7544; PHI:7545; PHI:7546; PHI:7547; PHI:7548; PHI:7549; PHI:7550; PHI:7551; PHI:7552	Klebsiella pneumoniae	KPPR1	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	(2,3-dihydroxybenzoyl)adenylate synthase	reduced virulence_unaffected pathogenicity	Gene deletion: full	28861522
C1_03342	AIK80529_ANN51031_CDO13425	87.3	284	1	34	1	284	1	282	1.35e-184	507.0	W9BNM8	PHI:7479_PHI:6565_PHI:6652	entB_entB (VK055_1923)	573	PHI:7480_PHI:7482; PHI:7539; PHI:7540; PHI:7541; PHI:7542; PHI:7483; PHI:7481; PHI:7478; PHI:7487; PHI:7486; PHI:7485; PHI:7484; PHI:7543; PHI:7544; PHI:7545; PHI:7546; PHI:7547; PHI:7548; PHI:7549; PHI:7550; PHI:7551; PHI:7552_PHI:7484; PHI:7485; PHI:7486; PHI:7487_nan_PHI:6566_PHI:6653; PHI:6651	Klebsiella pneumoniae	KPPR1_ST86	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Isochorismatase_Enterobactin and salmochelin	reduced virulence_unaffected pathogenicity	Gene deletion: full_Gene mutation	27624128_28861522_26056379
C1_03343	AIK80528	89.9	248	0	25	1	248	14	261	2.4800000000000003e-156	433.0	W9BF24	PHI:7485	EntA (VK055_1922)	573	PHI:7484; PHI:7479; PHI:7486; PHI:7487_PHI:7482; PHI:7539; PHI:7540; PHI:7541; PHI:7542; PHI:7483; PHI:7481; PHI:7478; PHI:7487; PHI:7486; PHI:7479; PHI:7484; PHI:7543; PHI:7544; PHI:7545; PHI:7546; PHI:7547; PHI:7548; PHI:7549; PHI:7550; PHI:7551; PHI:7552	Klebsiella pneumoniae	KPPR1	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	2,3-Dihydro-2,3-dihydroxybenzoate dehydrogenase	reduced virulence_unaffected pathogenicity	Gene deletion: full	28861522
C1_03344	AE005239_7	99.3	137	0	1	1	137	1	137	2.41e-101	284.0	Q8XBU9	PHI:6270	ybdB	562	nan	Escherichia coli	UTI89	urinary tract infection	Rodents	10090	Mus musculus (related: house mouse)	Proofreading thioesterase	lethal	Gene mutation	27073089
C1_03345	AAL19551	97.4	701	0	18	1	701	1	701	0.0	1305.0	Q8ZR28	PHI:7577	cstA	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028	salmonellosis	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	Peptide-utilizing carbon starvation protein	reduced virulence	Gene deletion: full	26497384
C1_03351	CAD16455	46.0	63	0	34	11	73	5	67	2.06e-07	50.1	P52698	PHI:123503_PHI:7611	phcA	305	nan	Ralstonia solanacearum	EP1_GMI1000	bacterial wilt	Eudicots	4081_4111	Solanum melongena (related: eggplant)_Solanum lycopersicum (related: tomato)	LysR-type transcriptional regulator	reduced virulence	Gene deletion: full_Gene deletion: full; gene complementation	28951474_36177460
C1_03353	AAL19559	98.4	187	0	3	1	187	1	187	3.23e-137	379.0	P0A251	PHI:11383	ahpC	28901	PHI:11384	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028	salmonellosis	Moths	7137	Galleria mellonella (related: greater wax moth)	Peroxiredoxin	reduced virulence	Gene deletion: full	33732665
C1_03368	nan	40.2	82	2	43	32	109	183	262	5.18e-06	44.7	A0A0K0GHV7	PHI:9021	PXO_RS05400	347	nan	Xanthomonas oryzae	pv. oryzae strain PXO99A	bacterial leaf blight	Monocots	4530	Oryza sativa (related: rice)	Response regulator	unaffected pathogenicity	Gene mutation	30828283
C1_03370	ABJ00040	97.8	186	0	4	1	186	1	186	1.37e-142	392.0	A0A0H2YXJ2	PHI:9385	pagP	562	PHI:9384	Escherichia coli	AE17	avian colibacillosis	Birds	9031	Gallus gallus (related: chicken)	Conserved hypothetical protein	reduced virulence_unaffected pathogenicity	Gene mutation; gene complementation	31326704
C1_03371	ACY87244	98.6	69	0	1	1	69	1	69	1.9499999999999997e-46	140.0	A0A0F6AYC2	PHI:7263	cspE	28901	PHI:7262_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain UMR1	salmonellosis	Rodents_Primates	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Cold shock protein	loss of pathogenicity_reduced virulence_unaffected pathogenicity	Gene deletion: full	28611217
C1_03375	AKA30976	58.1	320	2	131	1	320	1	317	1.15e-130	374.0	V5VBJ6	PHI:6492	lipA	470	nan	Acinetobacter baumannii	ATCC 17978	nosocomial infection	Rodents	10090	Mus musculus (related: house mouse)	Lipase	reduced virulence	Gene deletion: full	26668261
C1_03380	AAG07873	44.3	97	1	52	75	169	28	124	7.34e-18	77.4	Q9HVT6	PHI:5448	PA4485	287	nan	Pseudomonas aeruginosa	PAO1	nosocomial infection	Moths_Rodents	7137_10090	Galleria mellonella (related: greater wax moth)_Mus musculus (related: house mouse)	Cell envelope protein	unaffected pathogenicity	Gene mutation	26621210
C1_03388	BAA35288	100.0	193	0	0	1	193	1	193	9.51e-133	368.0	P0ADC1	PHI:10313	LptE	562	nan	Escherichia coli	KP7600	urinary tract infection	Moths_Rodents	10090_7091	Bombyx mori (related: domestic silkworm)_Mus musculus (related: house mouse)	LPS-assembly protein	unaffected pathogenicity_increased virulence (hypervirulence)	Gene mutation	32324807
C1_03403	AAO57627	56.5	292	1	126	10	300	7	298	6.46e-111	322.0	Q87XK7	PHI:10621	aatJ (PSPTO_4171)	317	nan	Pseudomonas syringae	pv. tomato strain DC3000	bacterial speck (tomato)	Eudicots	3702	Arabidopsis thaliana (related: thale cress)	Substrate-binding protein	reduced virulence	Gene deletion: full; gene complementation	32673374
C1_03405	AAC97167	40.0	508	13	282	15	512	13	507	3.45e-98	304.0	Q9ZI86	PHI:3782	PA3984	287	nan	Pseudomonas aeruginosa	PAO1	infection	Beetles	7067	Tenebrio molitor (related: yellow mealworm)	acyltransferases	reduced virulence	Altered gene expression / gene regulation: overexpression	23848169
C1_03407	CAL13026	79.4	155	0	32	1	155	1	155	4.29e-86	247.0	A1JQ74	PHI:7671	ybeY	630	nan	Yersinia enterocolitica	serotype O:3 strain 6471/76	yersiniosis	Primates	9606	Homo sapiens (related: human)	Endoribonuclease	reduced virulence	Gene deletion: full; gene complementation	25416689
C1_03418	CBA20089	87.4	554	1	69	1	553	1	554	0.0	997.0	D4HYW4	PHI:9327	asnB	552	nan	Erwinia amylovora	HKN06P1	fire blight	Eudicots	3750	Malus domestica (related: apple)	Asparagine synthase B	unaffected pathogenicity	Gene mutation	31152019
C1_03430	VEG82716	47.8	226	4	106	1	215	1	225	3.82e-59	184.0	A0A448KH20	PHI:123396	ulaD	730	nan	Haemophilus ducreyi	35000HP	chancroid	Primates	9606	Homo sapiens (related: human)	3-keto-L-gulonate-6-phosphate decarboxylase	unaffected pathogenicity	Gene deletion: full	35876728
C1_03440	AAO71335	81.7	676	1	123	1	676	1	675	0.0	1179.0	Q8Z2C1	PHI:9246	malS	28901	nan	Salmonella enterica	subsp. enterica serovar Typhi strain GIFU10007	salmonellosis	Primates	9606	Homo sapiens (related: human)	Regulatory non-coding RNA	reduced virulence	Altered gene expression / gene regulation: overexpression	29306008
C1_03445	CAJ13275	59.9	314	1	125	17	330	24	336	2.66e-127	366.0	Q2YJE8	PHI:9129	bab2_1109	235	nan	Brucella abortus	2308	brucellosis	Rodents	10090	Mus musculus (related: house mouse)	ABC transporter periplasmic binding protein	reduced virulence	Gene disruption; gene complementation	29632093
C1_03450	AAB18538	99.7	331	0	1	1	331	1	331	3.71e-242	656.0	P37669	PHI:11169	ataT	562	nan	Escherichia coli	serotype O157:H7 strain EDL933	neonatal sepsis; neonatal meningitis	Rodents_Primates	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Gcn5-related N-acetyltransferase (GNAT) family toxin	reduced virulence	Gene deletion: full	33732222
C1_03455	CAA62903	68.9	61	1	18	7	67	4	63	5.26e-26	89.0	P0A355	PHI:7637	CspA	1639	PHI:7638; PHI:7639_PHI:7639_PHI:7638_nan	Listeria monocytogenes	EGD-e	listeriosis	Bony fishes_Primates	7955_9606	Homo sapiens (related: human)_Danio rerio (related: zebrafish)	Cold shock protein	reduced virulence	Gene mutation	29124040
C1_03459	AAR83911	46.4	110	1	58	108	216	226	335	1.68e-20	86.7	Q6RYW5	PHI:9283_PHI:11889_PHI:11815_PHI:11127_PHI:11364	ompA_OmpA	470	nan	Acinetobacter baumannii	Ab169_ATCC 17978	pneumonia	Nematodes_Primates_Rodents	6239_10090_9606	Homo sapiens (related: human)_Caenorhabditis elegans (related: roundworm)_Mus musculus (related: house mouse)	Outer membrane protein	reduced virulence	Gene deletion: full_Gene deletion: full; gene complementation_Gene mutation	31121924_33436835_34675899_33807410
C1_03481	CAC86200	80.0	519	0	104	1	519	5	523	9e-314	853.0	Q8ZLB5	PHI:11602	bcsE	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain DMC4_subsp. enterica serovar Typhimurium strain DMC2	infection	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Cyclic di-GMP binding protein	reduced virulence	Gene mutation; gene complementation	34279609
C1_03484	ACY90746	88.3	871	0	102	1	871	1	871	0.0	1590.0	D0ZKI3	PHI:4694	bcsA	28901	PHI:4693_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	cellulose synthesis regulation	increased virulence (hypervirulence)	Gene mutation	25848006
C1_03488	WP_004161053.1	49.8	648	2	321	2	646	15	661	2.96e-214	612.0	D4I4B4	PHI:8644_PHI:8642	pdeC_pdeA	552	PHI:8642; PHI:8643_nan_PHI:8643; PHI:8644_PHI:8642_PHI:8643	Erwinia amylovora	Ea1189	fire blight	Eudicots	3750_23211	Malus domestica (related: apple)_Pyrus communis (related: pear)	Phosphodiesterase	reduced virulence_unaffected pathogenicity	Gene mutation; gene complementation	30366999
C1_03490	AE013987_5	62.1	478	1	180	1	477	1	478	1.35e-219	613.0	Q7CG15	PHI:4189	ypo3991	632	nan	Yersinia pestis	CO92	bubonic plague	Rodents	10090	Mus musculus (related: house mouse)	putative DNA binding protein	reduced virulence	Gene deletion: partial; gene complementation	24675805
C1_03496	ABF05598	98.8	323	0	4	1	323	1	323	2.29e-232	631.0	Q0SZB7	PHI:11592	yhjC	623	nan	Shigella flexneri	M90T	shigellosis	Rodents_Primates	10141_9606	Homo sapiens (related: human)_Cavia porcellus (related: domestic guinea pig)	LysR-type transcriptional regulator	reduced virulence	Gene deletion: full; gene complementation	34152261
C1_03497	AAL21998	48.4	64	1	32	138	200	157	220	2.85e-10	56.2	Q8ZM32	PHI:8811	STM3124	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	salmonellosis	Bony fishes	7955	Danio rerio (related: zebrafish)	Putative response regulator	reduced virulence	Gene deletion: full; gene complementation	30648943
C1_03500	AE004813_4	58.3	379	1	157	1	379	1	378	6.05e-145	420.0	Q9HX66	PHI:11623_PHI:11622	RhlE1 (PA3950)_RhlE2 (PA0428)	287	PHI:11623_PHI:11622_nan	Pseudomonas aeruginosa	PAO1	infection	Moths	7137	Galleria mellonella (related: greater wax moth)	DEAD-box RNA helicase	reduced virulence	Gene deletion: full; gene complementation	34151378
C1_03508	AAL19749	86.2	413	0	57	1	413	1	413	3.49e-277	752.0	Q8ZQP4	PHI:123209	clsB	28901	PHI:123208; PHI:123210_PHI:123210_nan_PHI:123208	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028s	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Cardiolipin synthase B	reduced virulence_unaffected pathogenicity	Gene deletion: full	35638781
C1_03514	CCP45921	58.5	159	2	63	4	161	8	164	2.27e-50	157.0	P9WJR9	PHI:7748	rv3111	1773	PHI:7746; PHI:7747; PHI:7749; PHI:7750; PHI:7751; PHI:7752	Mycobacterium tuberculosis	H37Rv	tuberculosis	Rodents	10090	Mus musculus (related: house mouse)	Involved in hypoxia-responsive molybdenum cofactor biosynthesis	reduced virulence_unaffected pathogenicity	Gene deletion: full; gene complementation	29176894
C1_03516	AAC73868	99.4	329	0	2	1	329	1	329	2.43e-246	667.0	P30745	PHI:10987	moaA	562	nan	Escherichia coli	PCN033	infection	Rodents	10090	Mus musculus (related: house mouse)	GTP 3',8-cyclase	unaffected pathogenicity	Gene deletion: full	32962530
C1_03518	AE014259_2	56.2	662	3	279	5	666	10	660	7.91e-256	719.0	Q8DYL6	PHI:11576	uvrB	1311	nan	Streptococcus agalactiae	group B serotype V strain CNCTC 10/84	group b streptococcal infection	Primates	9606	Homo sapiens (related: human)	Excinuclease ABC, B subunit	unaffected pathogenicity	Gene deletion: full; gene complementation	32747604
C1_03534	AAC23339	51.2	246	2	118	13	257	10	254	3.46e-76	230.0	P45323	PHI:5422	modA10	727	nan	Haemophilus influenzae	2866	nosocomial infection	Rodents	10114	Rattus (related: rat)	Phase-variable DNA methyltransferase	increased virulence (hypervirulence)	Gene mutation	26718097
C1_03538	CAA40568	57.7	338	0	143	1	338	1	338	4.09e-138	394.0	P24325	PHI:9264	galE	727	PHI:9263_nan	Haemophilus influenzae	NTHi 375	nosocomial infection	Rodents	10090	Mus musculus (related: house mouse)	UDP-glucose 4-epimerase	reduced virulence_unaffected pathogenicity	Gene mutation; gene complementation	31157175
C1_03540	CAA26172	99.7	382	0	1	1	382	1	382	6.57e-280	756.0	P0A6T3	PHI:6269	galK	562	nan	Escherichia coli	UTI89	urinary tract infection	Rodents	10090	Mus musculus (related: house mouse)	Galactokinase	reduced virulence	Gene mutation	27073089
C1_03543	CAD16367	64.2	352	1	123	1	349	1	352	6.04e-165	463.0	Q8XW15	PHI:8884	aroG1	305	PHI:8885_nan	Ralstonia solanacearum	OE1-1	bacterial wilt	Eudicots	4081_4097	Solanum lycopersicum (related: tomato)_Nicotiana tabacum (related: common tobacco)	Phospho-2-dehydro-3-deoxyheptonate aldolase	loss of pathogenicity	Gene deletion: full; gene complementation	30809210
C1_03556	CBA15086	40.5	84	1	49	71	153	254	337	3.06e-12	62.0	D2UB90	PHI:3937	OmpA1	29447	nan	Xanthomonas albilineans	XaFL07-1	leaf scald	Monocots	4547	Saccharum officinarum (related: sugarcane)	putative ompa family outer membrane protein precursor	reduced virulence	Gene mutation: characterised; gene complementation	23758144
C1_03557	CBG87511	97.0	430	0	13	1	430	1	430	3.31e-207	576.0	D2TPE2	PHI:10905	tolB	67825	nan	Citrobacter rodentium	DBS100	colitis	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Colicin import protein	reduced virulence	Gene deletion: full	32968151
C1_03558	AAG55075	93.7	395	1	24	1	395	1	394	3.11e-113	335.0	Q8X965	PHI:3472	TolA	562	nan	Escherichia coli	TW14359	infection	Moths	7137	Galleria mellonella (related: greater wax moth)	Periplasm spanning protein	reduced virulence	Gene mutation; gene complementation	25448467
C1_03560	CAD17823	43.6	218	1	121	3	220	13	228	1.12e-51	166.0	Q3J038	PHI:10834	RSp0672	305	PHI:10833; PHI:10835; PHI:10836; PHI:10837; PHI:10838; PHI:10839; PHI:10840; PHI:10841; PHI:10842; PHI:10843; PHI:10844; PHI:10845; PHI:10846; PHI:10847; PHI:10848; PHI:10849; PHI:10850; PHI:10851; PHI:10852; PHI:10853_PHI:10833; PHI:10835; PHI:10836; PHI:10837; PHI:10838; PHI:10839_PHI:10833; PHI:10835; PHI:10836; PHI:10837; PHI:10838; PHI:10839; PHI:10840; PHI:10841; PHI:10842; PHI:10843; PHI:10844; PHI:10845; PHI:10846; PHI:10847; PHI:10848_PHI:10833; PHI:10835; PHI:10836; PHI:10837; PHI:10838; PHI:10839; PHI:10840; PHI:10841; PHI:10842; PHI:10843; PHI:10844; PHI:10845; PHI:10846; PHI:10847; PHI:10848; PHI:10849; PHI:10850; PHI:10851; PHI:10852; PHI:10853; PHI:10854; PHI:10855; PHI:10856; PHI:10857; PHI:10858; PHI:10859; PHI:10860; PHI:10861; PHI:10862; PHI:10863; PHI:10864; PHI:10865; PHI:10866; PHI:10867; PHI:10868; PHI:10869; PHI:10870; PHI:10871; PHI:10872_PHI:10833; PHI:10835; PHI:10836; PHI:10837; PHI:10838; PHI:10839; PHI:10840; PHI:10841; PHI:10842; PHI:10843; PHI:10844; PHI:10845	Ralstonia solanacearum	OE1-1	bacterial wilt	Eudicots	4100_4111	Solanum melongena (related: eggplant)_Nicotiana benthamiana (no common name found)(non-host bioassay)	Effector protein	effector (plant avirulence determinant)	Gene deletion: full	32849353
C1_03571	ABD22597	42.2	434	9	202	5	404	3	421	4.28e-95	290.0	Q2FH26	PHI:7353	odhB	1280	nan	Staphylococcus aureus	JE2	skin infection; food poisoning; respiratory disease	Bony fishes	7955	Danio rerio (related: zebrafish)	Dihydrolipoamide succinyltransferase	unaffected pathogenicity	Gene mutation	28808156
C1_03572	EGY20389	40.1	979	13	522	11	932	68	1039	7.47e-229	674.0	G2XIN6	PHI:9378	VdOGDH (VDAG_10018)	27337	nan	Verticillium dahliae	Vd991	vascular wilt	Eudicots	3635	Gossypium hirsutum (related: cotton)	Alpha-oxoglutarate dehydrogenase	reduced virulence	Gene deletion: full; gene complementation	31422448
C1_03573	AAA23896	99.6	238	0	1	1	238	1	238	1.4500000000000002e-181	495.0	P07014	PHI:7965	sdhB	562	PHI:7962; PHI:7963; PHI:7964_nan	Escherichia coli	EDL933	urinary tract infection	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	Succinate dehydrogenase iron-sulfur subunit	reduced virulence	Gene mutation	29515100
C1_03574	AAA23895	99.8	588	0	1	1	588	1	588	0.0	1182.0	P0AC41	PHI:7964	sdhA	562	PHI:7966_PHI:7962; PHI:7963; PHI:7965_nan	Escherichia coli	EDL933	urinary tract infection	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	Succinate dehydrogenase flavoprotein subunit	reduced virulence	Gene mutation; gene complementation	29515100
C1_03575	AAA23894	100.0	115	0	0	1	115	1	115	1.8400000000000002e-72	209.0	P0AC44	PHI:7963	sdhD	562	PHI:7962; PHI:7964; PHI:7965_nan	Escherichia coli	EDL933	urinary tract infection	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	Succinate dehydrogenase	reduced virulence	Gene mutation	29515100
C1_03576	AAA23893	100.0	129	0	0	6	134	1	129	2.06e-86	246.0	P69054	PHI:7962	sdhC	562	nan_PHI:7963; PHI:7964; PHI:7965	Escherichia coli	EDL933	urinary tract infection	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	Succinate dehydrogenase	reduced virulence	Gene mutation	29515100
C1_03600	CBG90830	40.2	97	0	58	137	233	172	268	6.71e-18	79.3	D2TIS0	PHI:5244	RegA	67825	nan	Citrobacter rodentium	ICC180	nan	Rodents	10090	Mus musculus (related: house mouse)	Transcriptional regulator of virulence	reduced virulence	Gene mutation; gene complementation	25624355
C1_03609	AEE60096	65.6	326	2	107	1	321	1	326	1.01e-144	409.0	F4MD99	PHI:3113	stbA	562	nan	Escherichia coli	RS218	neonatal meningitis	Rodents	10114	Rattus (related: rat)	Stability protein for the plasmid	reduced virulence	Gene mutation: characterised; gene complementation	25164788
C1_03674	ACY89890	41.9	124	2	70	33	156	21	142	3.17e-25	93.6	A0A0F6B5U5	PHI:10098	STM14_RS15425 (iagB)	28901	PHI:10052; PHI:10053; PHI:10054; PHI:10055; PHI:10056; PHI:10057; PHI:10058; PHI:10059; PHI:10060; PHI:10061; PHI:10062; PHI:10063; PHI:10064; PHI:10065; PHI:10066; PHI:10067; PHI:10068; PHI:10069; PHI:10070; PHI:10071; PHI:10072; PHI:10073; PHI:10074; PHI:10075; PHI:10076; PHI:10077; PHI:10078; PHI:10079; PHI:10080; PHI:10081; PHI:10082; PHI:10083; PHI:10084; PHI:10085; PHI:10086; PHI:10087; PHI:10088; PHI:10089; PHI:10090; PHI:10091; PHI:10092; PHI:10093; PHI:10094; PHI:10095; PHI:10096; PHI:10097	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	SPI-1 type III secretion system invasion protein	unaffected pathogenicity	Gene deletion: full	32038592
C1_03692	ADN00484	63.5	271	2	95	1	271	5	271	1.68e-117	337.0	E0SLG2	PHI:8567	hdfR (Dda3937_04419)	204038	nan	Dickeya dadantii	3937	soft rot	Eudicots	13427	Cichorium intybus (related: chicory)	DNA-binding transcriptional regulator	reduced virulence	Gene deletion: full	30267562
C1_03694	CDO16329	76.0	505	0	121	1	505	1	505	2.9400000000000003e-272	747.0	W9BJ64	PHI:7572	yfiB	573	nan	Klebsiella pneumoniae	LM21	pneumonia	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	Outer membrane lipoprotein which acts as a sensor of YfiBNR system	unaffected pathogenicity	Gene deletion: full; gene complementation	25261190
C1_03695	EHA56980	43.7	568	12	280	14	544	95	659	4.44e-140	419.0	G4MMK2	PHI:3975	MoIlv2	318829	nan	Magnaporthe oryzae	Guy11	blast (rice)	Monocots	4530_4513	Oryza sativa (related: rice)_Hordeum vulgare (related: barley)	Acetolactate synthases	loss of pathogenicity	Gene disruption; gene complementation	23782532
C1_03699	CBA19104	85.8	514	0	73	2	515	1	514	0.0	881.0	D4HUI1	PHI:9318	ilvA	552	nan	Erwinia amylovora	HKN06P1	fire blight	Eudicots	3750	Malus domestica (related: apple)	Threonine dehydratase	reduced virulence	Gene mutation	31152019
C1_03702	ALD83589	94.6	92	0	5	1	92	1	92	5.91e-61	179.0	A0A0F7DJX4	PHI:11419	ppiC	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Peptidyl-prolyl cis-trans isomerase	reduced virulence	Gene deletion: full	31111418
C1_03707	BAA00903	100.0	109	0	0	1	109	1	109	7.68e-78	223.0	P0AA28	PHI:2644	thioredoxin 1	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028	food poisoning	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	Redox activity	reduced virulence	Chemical complementation_Gene deletion: full; gene complementation	23028994
C1_03708	AGU62228	52.0	415	5	190	7	419	24	431	1.15e-149	430.0	T1YC56	PHI:8558	Rho	1280	nan	Staphylococcus aureus	HG001	nosocomial infection	Rodents	10090	Mus musculus (related: house mouse)	Transcriptional regulator	increased virulence (hypervirulence)	Gene mutation; gene complementation	30228237
C1_03709	CDG14825	76.2	357	0	85	2	358	17	373	1.28e-199	552.0	V6A547	PHI:4074	wecA	615	nan	Serratia marcescens	2170	hemolymph bleeding	Moths	7091	Bombyx mori (related: domestic silkworm)	virulence factor	reduced virulence	Gene disruption	24530643
C1_03711	AE014976_8	51.1	370	2	172	1	369	4	365	3.2300000000000004e-123	359.0	Q8DTB7	PHI:7052	epsC	1309	nan	Streptococcus mutans	UA159	infective endocarditis	Primates_Rodents	10117_9606	Homo sapiens (related: human)_Rattus rattus (related: black rat)	Exopolysaccharide synthesis enzyme [UDP-N-acetylglucosamine 2-epimerase]	reduced virulence	Gene mutation; gene complementation	27572331
C1_03714	AE004929_3	66.0	285	0	97	2	286	4	288	1.53e-139	394.0	Q9HU22	PHI:7634	rmlA	287	nan	Pseudomonas aeruginosa	PAO1	infection	Eudicots_Rodents	4236_10090	Lactuca sativa (related: garden lettuce)_Mus musculus (related: house mouse)	Glucose-1-phosphate thymidylyltransferase	loss of pathogenicity_reduced virulence	Gene deletion: full	29045498
C1_03732	AAF93300	55.3	835	8	361	1	827	1	831	0.0	915.0	Q9KVL9	PHI:9840	cya	666	nan	Vibrio cholerae	SIO	infection	Flies	7227	Drosophila melanogaster (related: fruit fly)	Adenylate cyclase	reduced virulence	Gene deletion: full	30224439
C1_03744	HM852064	88.6	316	0	36	1	316	1	316	1.71e-203	557.0	E1AP33	PHI:2479	corA	554	nan	Pectobacterium carotovorum	KD100_subsp. carotovorum strain Ecc71	soft rot	Eudicots	4045_4039	Apium graveolens (no common name found)_Daucus carota (related: carrot)	Magnesium/nickel/cobalt transporter	reduced virulence	Gene disruption; gene complementation	21726393
C1_03758	ACT15089	84.8	310	0	47	1	310	1	310	9.14e-198	543.0	C6DI95	PHI:10576	PccS1_001441	554	nan	Pectobacterium carotovorum	subsp. carotovorum strain PccS1	soft rot	Monocots	69721	Zantedeschia aethiopica (related: arum-lily)	Transcriptional regulator, LysR family, MetR	unaffected pathogenicity	Gene deletion: full; gene complementation	32267092
C1_03759	CBA19150	85.4	752	1	109	1	751	1	752	0.0	1323.0	D4HUM7	PHI:9315	metE	552	nan	Erwinia amylovora	HKN06P1	fire blight	Eudicots	3750_4097	Malus domestica (related: apple)_Nicotiana tabacum (related: common tobacco)	5-Methyltetrahydropteroyltriglutamate-homocysteine methyltransferase	reduced virulence	Gene mutation	31152019
C1_03763	AHM70914	41.7	228	1	130	23	250	9	233	3.97e-57	181.0	W8TW76	PHI:10294	ubiE	1280	nan	Staphylococcus aureus	ATCC 29213	skin infection; food poisoning; respiratory disease	Primates	9606	Homo sapiens (related: human)	Ubiquinone biosynthesis methyltransferase	unaffected pathogenicity	Gene disruption; gene complementation	30642903
C1_03766	AAC76839	100.0	89	0	0	1	89	1	89	1.88e-53	159.0	P69428	PHI:10981	tatA	562	nan	Escherichia coli	PCN033	infection	Even-toed ungulates_Rodents	9823_10036_10090	Mesocricetus auratus (related: golden hamster)_Sus scrofa (related: pig)_Mus musculus (related: house mouse)	Sec-independent protein translocase protein	reduced virulence	Gene deletion: full; gene complementation	32962530
C1_03767	CAA06725	99.4	171	0	1	1	171	1	171	2.03e-105	297.0	P69425	PHI:10982	tatB	562	nan	Escherichia coli	PCN033	infection	Even-toed ungulates_Rodents	9823_10036_10090	Mesocricetus auratus (related: golden hamster)_Sus scrofa (related: pig)_Mus musculus (related: house mouse)	Sec-independent protein translocase protein	reduced virulence	Gene deletion: full; gene complementation	32962530
C1_03768	CAA06726	100.0	258	0	0	1	258	1	258	1.16e-172	474.0	P69423	PHI:10983	tatC	562	nan	Escherichia coli	PCN033	infection	Even-toed ungulates_Rodents	9823_10036_10090	Mesocricetus auratus (related: golden hamster)_Sus scrofa (related: pig)_Mus musculus (related: house mouse)	Sec-independent protein translocase protein	reduced virulence	Gene deletion: full; gene complementation	32962530
C1_03769	EGZ19258	40.1	177	4	94	1	168	58	231	4.84e-34	122.0	G4Z2B4	PHI:3071	PsTatD4	67593	nan	Phytophthora sojae	race 2 strain P6497	stem rot (soybean)	Eudicots	3847	Glycine max (related: soybean)	nuclease	reduced virulence	Altered gene expression / gene regulation: overexpression	2494098
C1_03773	ABB55459	40.7	354	8	192	45	386	10	357	1.62e-62	203.0	Q0QWD8	PHI:598	THIOL	5022	nan	Leptosphaeria maculans	ICBN 18	phoma stem canker	Eudicots	3708	Brassica napus (related: rape)	3-ketoacyl-CoA thiolase	reduced virulence	Altered gene expression / gene regulation: overexpression	16776292
C1_03782	CAJ11473	42.2	83	0	48	3	85	6	88	5.37e-10	57.8	Q2YRP4	PHI:5012	vtlR	235	nan	Brucella abortus	2308	brucellosis	Rodents	10090	Mus musculus (related: house mouse)	LysR-family transcriptional regulator	reduced virulence	Gene mutation; gene complementation	26175079
C1_03800	AAB09711	51.0	155	1	74	10	164	414	566	8.249999999999998e-42	145.0	P0C017	PHI:14	ADE2	5207	nan	Cryptococcus neoformans	var. grubii serotype A strain H99	cryptococcosis	Nematodes_Rabbits _ hares	6239_9986	Caenorhabditis elegans (related: roundworm)_Oryctolagus cuniculus (related: rabbit)	Phosphoribosylaminoimidazole carboxylase	loss of pathogenicity_reduced virulence	Gene disruption; gene complementation	12438649
C1_03802	ALD83591	98.2	164	0	3	1	164	1	164	9.22e-119	330.0	A0A0F7DI09	PHI:11418	ppiB	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Peptidyl-prolyl cis-trans isomerase	reduced virulence	Gene deletion: full	31111418
C1_03840	ACY88161	68.6	318	0	100	1	318	1	318	3.3999999999999994e-170	473.0	A0A0F6B0Y3	PHI:10119	STM14_RS07800 (orf319)	28901	PHI:10099; PHI:10100; PHI:10101; PHI:10102; PHI:10103; PHI:10104; PHI:10105; PHI:10106; PHI:10107; PHI:10108; PHI:10109; PHI:10110; PHI:10111; PHI:10112; PHI:10113; PHI:10114; PHI:10115; PHI:10116; PHI:10117; PHI:10118; PHI:10120; PHI:10121; PHI:10122; PHI:10123; PHI:10124; PHI:10125; PHI:10126; PHI:10127; PHI:10128; PHI:10129; PHI:10130; PHI:10131; PHI:10132; PHI:10133; PHI:10134; PHI:10135; PHI:10136; PHI:10137; PHI:10138; PHI:10139; PHI:10140; PHI:10141; PHI:10142; PHI:10143; PHI:10144; PHI:10145; PHI:10146; PHI:10147; PHI:10148; PHI:10149; PHI:10150; PHI:10151; PHI:10152	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	infection	Eudicots	4236	Lactuca sativa (related: garden lettuce)	DUF523 and DUF1722 domain-containing protein	reduced virulence	Gene deletion: full	32038592
C1_03862	ACL32202	59.6	47	0	19	730	776	784	830	3.57e-09	58.9	B8F4F0	PHI:3319	gpT	738	nan	Glaesserella parasuis	LC	glasser's disease	Rodents	10090	Mus musculus (related: house mouse)	involved in pathogenicity	reduced virulence	Other evidence	25283960
C1_03867	ACT14164	84.0	857	0	137	1	857	1	857	0.0	1367.0	C6DC70	PHI:10595	clpB	554	nan	Pectobacterium carotovorum	subsp. carotovorum strain PccS1	soft rot	Eudicots	3711_4097	Nicotiana tabacum (related: common tobacco)_Brassica rapa (related: field mustard)	Chaperone protein	unaffected pathogenicity	Gene deletion: full; gene complementation	32267092
C1_03871	CBA19780	82.1	112	0	20	1	112	1	112	5.98e-61	180.0	D4HX89	PHI:3675_PHI:3681	yfiA	552	nan	Erwinia amylovora	Ea1189	fire blight	Eudicots	3750_23211	Malus domestica (related: apple)_Pyrus communis (related: pear)	nan	unaffected pathogenicity	Gene mutation; gene complementation	23937726
C1_03876	CDO12935	60.0	165	1	63	5	169	13	174	3.4600000000000003e-66	198.0	W9BND0	PHI:7570	yfiR	573	nan	Klebsiella pneumoniae	LM21	pneumonia	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	Negative regulator of YfiBNR system	unaffected pathogenicity	Gene deletion: full; gene complementation	25261190
C1_03877	CDO12934	62.2	407	0	154	2	408	1	407	8.659999999999999e-170	479.0	W9B3Z6	PHI:7571	yfiN	573	nan	Klebsiella pneumoniae	LM21	pneumonia	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	c-di-GMP turnover enzyme	unaffected pathogenicity	Gene deletion: full; gene complementation	25261190
C1_03892	ABJ02039	100.0	160	0	0	1	160	1	160	2.56e-114	319.0	A1AEE9	PHI:4218	smpB	562	nan	Escherichia coli	E058	avian colibacillosis	Birds	9031	Gallus gallus (related: chicken)	trans -translation is a bacterial translational control system that directs the modification and degradation of proteins,	reduced virulence	Gene disruption; gene complementation	24013628
C1_03947	QVP88165	64.9	385	8	104	1	377	1	362	1.62e-165	466.0	A0A8E6NBK9	PHI:123435	ompD	28901	PHI:123431_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028s	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Porin OmpD	reduced virulence_unaffected pathogenicity	Gene deletion: full	35969640
C1_03960	CAR50527	66.1	301	0	102	6	306	26	326	1.4e-153	431.0	B4E5A2	PHI:9576_PHI:3524	paaA	95486	PHI:9577; PHI:9578; PHI:9579; PHI:9580; PHI:9582_PHI:9577; PHI:9578; PHI:9579; PHI:9580_PHI:3525; PHI:3170; PHI:3171; PHI:3172_PHI:9577; PHI:9578; PHI:9579; PHI:9580; PHI:9581	Burkholderia cenocepacia	K56-2	cystic fibrosis_cystic fibrosis-like disease	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	Phenylacetic acid degradation protein_phenylacetic acid catabolism	reduced virulence	Gene deletion: full_Gene deletion: full; gene complementation	25155974_31585996
C1_03961	CAR50526	65.6	93	0	32	3	95	2	94	3.97e-44	136.0	B4E5A1	PHI:3170	paaB	95486	PHI:3524; PHI:3525; PHI:3171; PHI:3172	Burkholderia cenocepacia	K56-2	cystic fibrosis	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	phenylacetic acid catabolism	reduced virulence	Gene deletion: full; gene complementation	25155974
C1_03962	CAR50525	45.2	259	2	126	6	248	9	267	1.69e-69	213.0	B4E5A0	PHI:3525_PHI:9578	paaC	95486	PHI:3524; PHI:3170; PHI:3171; PHI:3172_PHI:9576; PHI:9577; PHI:9579; PHI:9580_PHI:9576; PHI:9577; PHI:9579; PHI:9580; PHI:9581_PHI:9576; PHI:9577; PHI:9579; PHI:9580; PHI:9582	Burkholderia cenocepacia	K56-2	cystic fibrosis_cystic fibrosis-like disease	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	Phenylacetic acid degradation protein_phenylacetic acid catabolism	reduced virulence	Gene deletion: full_Gene deletion: full; gene complementation	25155974_31585996
C1_03963	CAR50524	46.7	167	4	75	10	163	17	182	1.51e-47	151.0	B4E599	PHI:3171	paaD	95486	PHI:3524; PHI:3525; PHI:3170; PHI:3172	Burkholderia cenocepacia	K56-2	cystic fibrosis	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	phenylacetic acid catabolism	reduced virulence	Gene deletion: full; gene complementation	25155974
C1_03964	CAR50523	46.1	358	3	184	4	353	6	362	6.55e-105	311.0	B4E598	PHI:9580_PHI:3172	paaE	95486	PHI:9576; PHI:9577; PHI:9578; PHI:9579; PHI:9581_PHI:9576; PHI:9577; PHI:9578; PHI:9579; PHI:9582_PHI:9576; PHI:9577; PHI:9578; PHI:9579_PHI:3524; PHI:3525; PHI:3170; PHI:3171	Burkholderia cenocepacia	K56-2	cystic fibrosis_cystic fibrosis-like disease	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	phenylacetic acid catabolism_Putative phenylacetic acid degradation NADH oxidoreductase	reduced virulence	Gene deletion: full_Gene deletion: full; gene complementation	25155974_31585996
C1_03965	CEF85795	41.8	239	2	137	16	252	49	287	2.35e-54	175.0	I1S8D3	PHI:9517	FgEch1 (FGSG_13111)	5518	nan	Fusarium graminearum	PH-1	fusarium head blight	Monocots	4565	Triticum aestivum (related: bread wheat)	Enoyl-CoA hydratase	reduced virulence	Gene deletion: full; gene complementation	31463774
C1_03966	AIO32166	52.8	250	2	116	13	262	16	263	6.94e-87	258.0	A0A088U4K2	PHI:9577	paaB	95486	PHI:9576; PHI:9578; PHI:9579; PHI:9580_PHI:9576; PHI:9578; PHI:9579; PHI:9580; PHI:9581_PHI:9576; PHI:9578; PHI:9579; PHI:9580; PHI:9582	Burkholderia cenocepacia	K56-2	cystic fibrosis-like disease	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	Phenylacetate degradation putative enoyl-CoA hydratase	reduced virulence	Gene deletion: full	31585996
C1_03968	AIO34196	52.6	133	3	59	9	139	18	148	2.03e-41	133.0	A0A088UAI6	PHI:9579	paaD	95486	PHI:9576; PHI:9577; PHI:9578; PHI:9580_PHI:9576; PHI:9577; PHI:9578; PHI:9580; PHI:9582_PHI:9576; PHI:9577; PHI:9578; PHI:9580; PHI:9581	Burkholderia cenocepacia	K56-2	cystic fibrosis-like disease	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	Phenylacetic acid degradation protein	reduced virulence	Gene deletion: full	31585996
C1_03970	ONU93896	67.5	428	3	136	7	432	11	437	2.42e-211	587.0	A0A1V2WCB4	PHI:9584	paaK2	95486	PHI:9583; PHI:9582_PHI:9583; PHI:9581_PHI:9583_nan	Burkholderia cenocepacia	K56-2	cystic fibrosis-like disease	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	Phenylacetate-coenzyme A ligase	reduced virulence_unaffected pathogenicity_increased virulence (hypervirulence)	Gene deletion: full	31585996
C1_03982	CAB38645	58.7	334	5	132	3	333	4	334	8.68e-131	375.0	P0A038	PHI:6904	GAPDH	1280	nan	Staphylococcus aureus	USA300 JE2	white muscardine	Moths	7137	Galleria mellonella (related: greater wax moth)	Glyceraldehyde-3-phosphate dehydrogenase	reduced virulence	Functional test in host: direct injection	27001537
C1_03986	ACY88437	69.1	521	0	161	6	526	10	530	3.0700000000000006e-179	514.0	A0A0F6B1Q1	PHI:6982	trg	28901	PHI:6979; PHI:6980; PHI:6981; PHI:6983; PHI:6984_PHI:6979; PHI:6980; PHI:6981_PHI:6979; PHI:6980; PHI:6981; PHI:6983; PHI:6984; PHI:6985_PHI:6979; PHI:6980; PHI:6981; PHI:6983	Salmonella enterica	subsp. enterica serovar Typhimurium strain NCTC 12023	salmonellosis	Primates	9606	Homo sapiens (related: human)	Methyl-accepting chemotaxis protein	reduced virulence	Gene deletion: full	28212413
C1_03989	AAC74506	99.8	539	0	1	1	539	13	551	0.0	1126.0	P40120	PHI:10993	mdoD	562	nan	Escherichia coli	PCN033	infection	Rodents	10090	Mus musculus (related: house mouse)	Glucans biosynthesis protein D	unaffected pathogenicity	Gene deletion: full	32962530
C1_04085	AAC74584	99.8	530	0	1	1	530	1	530	0.0	1063.0	P77432	PHI:9990	lsrK	562	nan	Escherichia coli	APEC94	meningitis	Birds	8839	Anas platyrhynchos (related: mallard)	Autoinducer-2 kinase	reduced virulence	Gene deletion: full; gene complementation	31831050
C1_04086	AAC74585	98.7	317	0	4	1	317	1	317	1.07e-202	555.0	P76141	PHI:9991	lsrR	562	nan	Escherichia coli	APEC94	meningitis	Birds	8839	Anas platyrhynchos (related: mallard)	DNA-binding transcriptional repressor	reduced virulence	Gene deletion: full; gene complementation	31831050
C1_04087	AAC74586	98.8	511	0	6	1	511	1	511	0.0	970.0	P77257	PHI:9992	lsrA	562	nan	Escherichia coli	APEC94	meningitis	Birds	8839	Anas platyrhynchos (related: mallard)	Autoinducer-2 ABC transporter ATP binding subunit	reduced virulence	Gene deletion: full; gene complementation	31831050
C1_04088	AAC74587	99.7	342	0	1	1	342	1	342	2.57e-234	637.0	P77672	PHI:9993	lsrC	562	nan	Escherichia coli	APEC94	meningitis	Birds	8839	Anas platyrhynchos (related: mallard)	Autoinducer-2 ABC transporter membrane subunit 	reduced virulence	Gene deletion: full; gene complementation	31831050
C1_04089	AAC74588	100.0	330	0	0	1	330	1	330	2.3400000000000003e-224	611.0	P0AFS1	PHI:9994	lsrD	562	nan	Escherichia coli	APEC94	meningitis	Birds	8839	Anas platyrhynchos (related: mallard)	Autoinducer-2 ABC transporter membrane subunit	reduced virulence	Gene deletion: full; gene complementation	31831050
C1_04090	AAC74589	98.8	340	0	4	1	340	1	340	3.87e-244	662.0	P76142	PHI:9995	lsrB	562	nan	Escherichia coli	APEC94	meningitis	Birds	8839	Anas platyrhynchos (related: mallard)	Autoinducer-2 ABC transporter periplasmic binding protein	reduced virulence	Gene deletion: full; gene complementation	31831050
C1_04091	AAC74590	99.3	291	0	2	1	291	1	291	1.7000000000000003e-211	575.0	P76143	PHI:9996	lsrF	562	nan	Escherichia coli	APEC94	meningitis	Birds	8839	Anas platyrhynchos (related: mallard)	3-Hydroxy-2,4-pentadione 5-phosphate thiolase 	reduced virulence	Gene deletion: full; gene complementation	31831050
C1_04092	AAC74591	99.0	96	0	1	1	96	1	96	1.21e-68	198.0	P64461	PHI:9997	lsrG	562	nan	Escherichia coli	APEC94	meningitis	Birds	8839	Anas platyrhynchos (related: mallard)	(4S)-4-Hydroxy-5-phosphonooxypentane-2,3-dione isomerase	reduced virulence	Gene deletion: full; gene complementation	31831050
C1_04106	AAX65443	95.2	126	0	6	1	126	1	126	1.69e-85	243.0	Q57PB8	PHI:5369	MarA	28901	nan	Salmonella enterica	subsp. enterica serovar Choleraesuis strain ATCC13312	bacteremia	Rodents	10090	Mus musculus (related: house mouse)	Transcriptional regulator	reduced virulence	Gene mutation	26608721
C1_04112	AE014206_15	41.0	105	3	55	1	102	1	101	3.81e-15	63.9	Q8E1M5	PHI:8620	cel-EIIB (SAG0329)	1311	nan	Streptococcus agalactiae	THN0901	neonatal pneumonia; neonatal meningitis; bovine mastitis; meningoencephalitis (fish)	Bony fishes	8128	Oreochromis niloticus (related: nile tilapia)	Phosphoenolpyruvate (PEP)-dependent sugar phosphotransferase system (PTS), cellobiose-specific IIB component	reduced virulence	Gene deletion: full; gene complementation	30374993
C1_04121	AIK80567	49.2	248	3	122	3	247	1	247	3.89e-79	237.0	A0A076ZHT9	PHI:7511	VK055_1961	573	PHI:7488; PHI:7489; PHI:7490; PHI:7476; PHI:7475; PHI:7477; PHI:7491; PHI:7492; PHI:7493; PHI:7494; PHI:7495; PHI:7496; PHI:7497; PHI:7498; PHI:7499; PHI:7500; PHI:7501; PHI:7502; PHI:7503; PHI:7504; PHI:7505; PHI:7506; PHI:7507; PHI:7508; PHI:7509; PHI:7510; PHI:7512	Klebsiella pneumoniae	KPPR1	pneumonia	Rodents	10090	Mus musculus (related: house mouse)	Serine 3-dehydrogenase	unaffected pathogenicity	Gene deletion: full	28861522
C1_04128	AE005492_1	95.5	22	0	1	145	166	7	28	4.74e-06	40.4	Q8X415	PHI:6736	Z3917	562	nan	Escherichia coli	EDL933	urinary tract infection	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	nan	increased virulence (hypervirulence)	Gene mutation; gene complementation	27655246
C1_04145	EEQ46193	48.0	483	12	212	3	449	36	515	2.8e-140	410.0	C4YR40	PHI:4904	Glr1	5476	nan	Candida albicans	nan	disseminated candidiasis	Moths_Rodents	7137_10090	Galleria mellonella (related: greater wax moth)_Mus musculus (related: house mouse)	Glutathione recycling enzymes/ glutathione reductase	reduced virulence	Gene disruption; gene complementation	26039593
C1_04147	AAA25276	46.3	67	0	36	8	74	33	99	1.81e-13	60.5	Q56405	PHI:11287_PHI:7387	cadC_CadC	1639	PHI:7386_nan	Listeria monocytogenes	serotype 1/2a strain EGD-e_EGD-e	listeriosis	Rodents	10090	Mus musculus (related: house mouse)	Cadmium resistance transcriptional regulatory protein_Cadmium-dependent efflux pump regulator	reduced virulence_unaffected pathogenicity	Gene deletion: full; gene complementation_Gene mutation; gene complementation	28368435_31955655
C1_04153	AAA60370	99.5	188	0	1	1	188	1	188	3.11e-140	387.0	P37194	PHI:9256	slp	562	nan	Escherichia coli	serotype O157:H7 strain EDL932	urinary tract infection	Primates	9606	Homo sapiens (related: human)	Carbon starvation-inducible lipoprotein	reduced virulence	Gene deletion: full; gene complementation	31188867
C1_04154	AAC76532	100.0	176	0	0	1	176	1	176	1.28e-124	346.0	P37195	PHI:11605	dctR	562	nan	Escherichia coli	CE08	avian colibacillosis	Birds	8839_9031	Gallus gallus (related: chicken)_Anas platyrhynchos (related: mallard)	Putative DNA-binding transcriptional regulator	reduced virulence	Gene deletion: full; gene complementation	34229767
C1_04155	ACC41130	43.4	113	4	53	3	114	7	109	3.43e-20	84.0	B2HSV6	PHI:3593	MgtC	1781	nan	Mycobacterium marinum	M	opportunistic infection	Bony fishes	7955	Danio rerio (related: zebrafish)	intramacrophage growth/Mg2+ transport p-type ATPase	unaffected pathogenicity	Gene deletion: full; gene complementation	25545682
C1_04164	AF221126_1	40.3	67	1	37	167	233	176	239	1.22e-06	46.6	Q9S1J0	PHI:3008	zmpR	1313	nan	Streptococcus pneumoniae	serotype 4 strain TIGR4	pneumonia; otitis media; septicemia; meningitis	Rodents	10090	Mus musculus (related: house mouse)	Putative response regulator	unaffected pathogenicity	Gene mutation	12207705
C1_04176	AAY48437	51.7	145	3	67	1	143	1	144	8.170000000000001e-43	137.0	Q4UWY6	PHI:3951	XC_1368	339	nan	Xanthomonas campestris	pv. campestris strain 8004	black rot	Eudicots	3726	Raphanus sativus (related: radish)	Osmotically inducible protein, oxidative stress resistance	reduced virulence	Gene mutation	23819805
C1_04184	AAD13438	99.6	803	0	3	1	803	213	1015	0.0	1662.0	P24183	PHI:10997	fdnG	562	nan	Escherichia coli	PCN033	infection	Rodents	10090	Mus musculus (related: house mouse)	Formate dehydrogenase, nitrate-inducible, major subunit	unaffected pathogenicity	Gene deletion: full	32962530
C1_04189	ACY88374	85.5	462	0	67	1	462	1	462	6.370000000000001e-291	791.0	A0A0F6B1I9	PHI:123381	narU	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028s	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Nitrate/nitrite transporter	unaffected pathogenicity	Gene deletion: full	35806223
C1_04190	AAC74550	99.8	1246	0	2	1	1246	1	1246	0.0	2609.0	P19319	PHI:10516	narZ	562	PHI:10512; PHI:10513; PHI:10514; PHI:10515; PHI:10517; PHI:10518; PHI:10519; PHI:10520; PHI:10521; PHI:10522; PHI:10523; PHI:10524; PHI:10525; PHI:10526	Escherichia coli	CFT073	urinary tract infection	Rodents	10117	Rattus rattus (related: black rat)	Respiratory nitrate reductase 2 alpha chain	reduced virulence	Gene deletion: full; gene complementation	32082279
C1_04191	AAC74549	99.6	514	0	2	1	514	1	514	0.0	1076.0	P19318	PHI:10517	narY	562	PHI:10512; PHI:10513; PHI:10514; PHI:10515; PHI:10516; PHI:10518; PHI:10519; PHI:10520; PHI:10521; PHI:10522; PHI:10523; PHI:10524; PHI:10525; PHI:10526	Escherichia coli	CFT073	urinary tract infection	Rodents	10117	Rattus rattus (related: black rat)	Respiratory nitrate reductase 2 beta chain	reduced virulence	Gene deletion: full; gene complementation	32082279
C1_04192	AAC74548	99.6	231	0	1	1	231	1	231	2.58e-167	459.0	P19317	PHI:10518	narW	562	PHI:10512; PHI:10513; PHI:10514; PHI:10515; PHI:10516; PHI:10517; PHI:10519; PHI:10520; PHI:10521; PHI:10522; PHI:10523; PHI:10524; PHI:10525; PHI:10526	Escherichia coli	CFT073	urinary tract infection	Rodents	10117	Rattus rattus (related: black rat)	Probable nitrate reductase molybdenum cofactor assembly chaperone	reduced virulence	Gene deletion: full; gene complementation	32082279
C1_04193	BAA15102	99.6	226	0	1	1	226	1	226	6.86e-165	452.0	P0AF32	PHI:10519	narV	562	PHI:10512; PHI:10513; PHI:10514; PHI:10515; PHI:10516; PHI:10517; PHI:10518; PHI:10520; PHI:10521; PHI:10522; PHI:10523; PHI:10524; PHI:10525; PHI:10526	Escherichia coli	CFT073	urinary tract infection	Rodents	10117	Rattus rattus (related: black rat)	Respiratory nitrate reductase 2 gamma chain	reduced virulence	Gene deletion: full; gene complementation	32082279
C1_04214	AF220439_2	71.0	255	0	74	1	255	1	255	5.77e-123	349.0	Q9L7R1	PHI:6545	yihW	28901	PHI:6544	Salmonella enterica	subsp. enterica serovar Typhimurium strain 14028s	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	O-Antigen Capsule	unaffected pathogenicity	Gene deletion: full; gene complementation	26195553
C1_04218	CAL18716	88.9	606	0	67	1	606	1	606	0.0	1075.0	A0A380PIP1	PHI:11030	bipA	632	nan	Yersinia pestis	CO92	pneumonic plague	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Putative GTPase	reduced virulence	Gene deletion: full; gene complementation	33257531
C1_04219	AAL22846	98.1	469	0	9	1	469	1	469	0.0	929.0	P0A1P6	PHI:7742	glnA	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain LT2	salmonellosis	Primates	9606	Homo sapiens (related: human)	Glutamine synthetase	reduced virulence	Gene deletion: full; chemical complementation	29150501
C1_04220	AE004925_7	47.3	347	5	173	12	349	10	355	3.81e-101	301.0	Q9HU60	PHI:11699	ntrB	287	nan_PHI:11700	Pseudomonas aeruginosa	LESB58	opportunistic infection	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Histidine kinase	reduced virulence	Gene deletion: full; gene complementation	34249781
C1_04221	ABR83279	69.5	463	1	137	6	468	7	465	5.73e-227	630.0	A6VDP3	PHI:123267	ntrC	287	PHI:123266_nan	Pseudomonas aeruginosa	LESB58	opportunistic infection	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	DNA-binding transcriptional regulator NtrC	reduced virulence	Gene mutation; gene complementation_Gene mutation	35637237
C1_04229	CBG90603	87.0	208	1	26	1	208	1	207	4.25e-134	373.0	D2TUX9	PHI:8691	dsbA (ROD_38991)	67825	nan	Citrobacter rodentium	DBS100	colitis	Rodents	10090	Mus musculus (related: house mouse)	Thiol:disulfide interchange protein	loss of pathogenicity	Gene deletion: full; gene complementation	30536519
C1_04230	CBG90604	85.1	328	0	49	1	328	1	328	4.8199999999999987e-216	590.0	D2TUY0	PHI:8692	rdoA (ROD_39001)	67825	nan	Citrobacter rodentium	DBS100	colitis	Rodents	10090	Mus musculus (related: house mouse)	Putative regulatory protein kinase	unaffected pathogenicity	Promoter mutation	30536519
C1_04232	AAX87890	40.3	186	1	109	6	189	4	189	3.48e-45	146.0	Q4QM57	PHI:5304	mobA	727	nan	Haemophilus influenzae	NTHI 2019	acute respiratory tract disease; chronic respiratory tract disease	Rodents	10090	Mus musculus (related: house mouse)	MobA protein catalyzes the final step in the synthesis of the molybdenum guanine dinucleotide (MGD) cofactor that is exclusive to enzymes of the DMSO reductase family.	unaffected pathogenicity	Gene mutation; gene complementation	26594204
C1_04238	AAF71498	41.0	266	3	152	12	274	79	342	1.57e-65	215.0	Q9JP38	PHI:2975	ipx10	317	nan	Pseudomonas syringae	pv. tomato strain DC3000	bacterial speck (tomato)	Eudicots	4081_3702	Solanum lycopersicum (related: tomato)_Arabidopsis thaliana (related: thale cress)	Effector	effector (plant avirulence determinant)	Gene mutation	11967070
C1_04249	OTE56952	77.0	1176	2	267	1	1174	1	1175	0.0	1809.0	A0A0L7AFE5	PHI:12052	icmF	562	nan	Escherichia coli	APEC O18	colibacillosis	Eukaryotes	44689	Dictyostelium discoideum (related: amoeba)	Type VI secretion system protein	unaffected pathogenicity	Gene deletion: full; gene complementation	35003930
C1_04252	KF678350	88.5	942	4	82	1	939	1	919	0.0	1552.0	Q6TKU1	PHI:4559	T6SS2	562	PHI:4560	Escherichia coli	TW-XM	meningitis	Birds	8839	Anas platyrhynchos (related: mallard)	Type VI secretion systems (T6SSs) effectors	effector (plant avirulence determinant)	Gene mutation; gene complementation	24980972
C1_04253	BAB33647	98.4	253	0	4	1	253	1	253	8.67e-186	507.0	Q8X7V4	PHI:12050	impK	562	nan	Escherichia coli	APEC O18	colibacillosis	Eukaryotes	44689	Dictyostelium discoideum (related: amoeba)	Type VI secretion system protein	unaffected pathogenicity	Gene deletion: full; gene complementation	35003930
C1_04254	SHH56903	46.4	446	5	231	3	443	2	444	6.28e-133	389.0	A0A1M5U2L7	PHI:10596	impJ	554	nan	Pectobacterium carotovorum	subsp. carotovorum strain PccS1	soft rot	Eudicots	3711_4097	Nicotiana tabacum (related: common tobacco)_Brassica rapa (related: field mustard)	Type VI secretion system protein	unaffected pathogenicity	Gene deletion: full; gene complementation	32267092
C1_04260	ARR32081	99.8	491	0	1	1	491	1	491	0.0	984.0	A0A069FIK9	PHI:12051	evpB	562	nan	Escherichia coli	APEC O18	colibacillosis	Eukaryotes	44689	Dictyostelium discoideum (related: amoeba)	Type VI secretion system protein	unaffected pathogenicity	Gene deletion: full; gene complementation	35003930
C1_04263	AKK46827	100.0	172	0	0	1	172	1	172	1.51e-130	361.0	A0A0G3K3H0	PHI:8554	hcp2	562	nan_PHI:8553	Escherichia coli	CE129	avian colibacillosis	Birds	9031	Gallus gallus (related: chicken)	Hemolysin co-regulation protein	reduced virulence	Gene deletion: full; gene complementation	30247772
C1_04264	ADD54889	99.2	713	0	6	1	713	1	713	0.0	1166.0	D3QWN3	PHI:4560	VgrG	562	nan	Escherichia coli	TW-XM	meningitis	Birds	8839	Anas platyrhynchos (related: mallard)	Type VI secretion systems (T6SSs) effectors	effector (plant avirulence determinant)	Gene mutation; gene complementation	24980972
C1_04276	CBA19084	83.6	883	0	145	1	883	1	883	0.0	1494.0	D4HUG1	PHI:9322	ppc	552	nan	Erwinia amylovora	HKN06P1	fire blight	Eudicots	3750	Malus domestica (related: apple)	Phosphoenolpyruvate carboxylase	unaffected pathogenicity	Gene mutation	31152019
C1_04280	ABD20820.1	47.9	453	1	235	4	456	6	457	1.26e-147	427.0	Q2FIB5	PHI:2632	argH	1280	nan	Staphylococcus aureus	USA300 JE2	community-acquired infection; nosocomial infection	Rodents	10090	Mus musculus (related: house mouse)	Argininosuccinate lyase	reduced virulence	Gene disruption	23209408
C1_04283	BAI33414	100.0	305	0	0	1	305	1	305	5.34e-222	603.0	C8TZQ2	PHI:3714	OxyR	562	nan	Escherichia coli	UCB34 (O17:K+:H18)	urinary tract infection	Rodents	10090	Mus musculus (related: house mouse)	oxidative stress response regulator	reduced virulence	Gene mutation; gene complementation	23850958
C1_04295	CCP43395	43.3	127	2	64	3	121	4	130	1.22e-17	71.6	P9WHE3	PHI:7583	Rv0652 (rplL)	1773	nan	Mycobacterium tuberculosis	CDC1551	tuberculosis	Primates	9606	Homo sapiens (related: human)	50S ribosomal protein	increased virulence (hypervirulence)	Altered gene expression / gene regulation: overexpression	26605666
C1_04296	ABO10757	70.9	1363	10	366	1	1338	1	1357	0.0	1868.0	A3M1G3	PHI:7860	RpoB	470	nan	Acinetobacter baumannii	ATCC 17978	nosocomial infection	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	beta-subunit of the RNA polymerase	reduced virulence	Gene mutation; gene complementation	28507065
C1_04299	AAO53978	45.1	253	2	136	4	253	12	264	1.77e-62	195.0	Q88AF6	PHI:123321	thiG (pspto_0434)	317	PHI:123318; PHI:123319; PHI:123320_PHI:123320	Pseudomonas syringae	pv. tomato strain DC3000	bacterial speck	Eudicots	4081	Solanum lycopersicum (related: tomato)	Thiazole synthase	reduced virulence	Gene deletion: full; gene complementation	35783427
C1_04309	ACY83030	94.4	90	0	5	1	90	1	90	5.81e-53	158.0	D0Z9U0	PHI:3074	hupA	636	nan	Edwardsiella tarda	EIB202	hemorrhagic septicemia	Bony fishes	7955	Danio rerio (related: zebrafish)	Nucleoid-associated protein, is a basic DNA-binding protein involved in gene regulation	reduced virulence	Gene mutation: characterised; gene complementation	24793099
C1_04314	nan	45.7	446	7	222	8	439	4	443	6.56e-111	332.0	A0A0K0GGF6	PHI:9014	PXO_RS02690	347	nan	Xanthomonas oryzae	pv. oryzae strain PXO99A	bacterial leaf blight	Monocots	4530	Oryza sativa (related: rice)	Response regulator	unaffected pathogenicity	Gene mutation	30828283
C1_04315	AAY47590	69.7	429	1	129	1	429	1	428	7.7e-206	573.0	Q4UZD3	PHI:3942	XC_0509	339	nan	Xanthomonas campestris	pv. campestris strain 8004	black rot	Eudicots	3726	Raphanus sativus (related: radish)	Phosphoribosylamine-glycine ligase	reduced virulence	Gene mutation	23819805
C1_04319	AE004591_3	60.3	675	5	255	7	681	28	689	3.0300000000000002e-257	724.0	P57698	PHI:4712	kdpB	287	nan	Pseudomonas aeruginosa	PAO1-L	nosocomial infection	Nematodes_Rodents_Flies	7227_6239_10090	Caenorhabditis elegans (related: roundworm)_Drosophila melanogaster (related: fruit fly)_Mus musculus (related: house mouse)	Transport of small molecules	reduced virulence	Gene mutation	25845292
C1_04322	AAZ36556	52.0	221	0	106	4	224	7	227	1.88e-79	236.0	Q48K32	PHI:6314	kdpE	317	nan	Pseudomonas syringae	MB03	bacterial speck	Nematodes	6239	Caenorhabditis elegans (related: roundworm)	Potassium homeostasis and virulence	increased virulence (hypervirulence)	Gene mutation	27303387
C1_04325	AAC73786	100.0	439	0	0	1	439	1	439	1.94e-310	838.0	P0AAF1	PHI:9154	potE	562	nan	Escherichia coli	APEC serotype O83:H4 ST117	colibacillosis	Birds	9031	Gallus gallus (related: chicken)	nan	unaffected pathogenicity	Gene mutation; gene complementation	29519523
C1_04331	CAA26429	100.0	148	0	0	1	148	1	148	1.36e-110	308.0	P0A9A9	PHI:4887	Fur	562	nan_PHI:4886	Escherichia coli	CFT073	urinary tract infection	Rodents	10090	Mus musculus (related: house mouse)	global ferric uptake regulator	reduced virulence_unaffected pathogenicity	Gene deletion: full_Gene deletion: full; gene complementation	25245805
C1_04337	EHA48815	60.2	259	0	103	1	259	1	259	1.2e-116	337.0	G4NB53	PHI:5472	MoDeam	318829	nan	Magnaporthe oryzae	KJ201	blast (rice)	Monocots	4530	Oryza sativa (related: rice)	GlcN-6-phosphate deaminase	reduced virulence	Gene deletion: full; gene complementation	26754109
C1_04343	AEQ98404	45.0	269	5	142	4	267	6	273	1.33e-62	197.0	G7TM49	PHI:7791	AroE (XOC_4333)	347	nan	Xanthomonas oryzae	pv. oryzicola strain RS105	bacterial blight (rice)	Monocots	4530	Oryza sativa (related: rice)	Shikimate 5-dehydrogenase	reduced virulence	Gene deletion: full; gene complementation	29256829
C1_04347	AAK99947	44.1	204	2	112	82	285	81	282	3.4700000000000004e-43	150.0	Q8DPI7	PHI:11059	dprA	1313	PHI:11060_nan	Streptococcus pneumoniae	serotype 2 strain D39	pneumococcal pneumonia	Rodents	10090	Mus musculus (related: house mouse)	DNA processing protein	reduced virulence_increased virulence (hypervirulence)	Gene deletion: full	31451619
C1_04350	CAG76898	71.5	428	0	122	1	428	1	428	1.3399999999999999e-229	633.0	Q6D000	PHI:2694	rsmB	29471	PHI:2695_nan	Pectobacterium atrosepticum	SCRI 1043	tuber rot; blackleg disease	Eudicots	4113	Solanum tuberosum (related: potato)	Modulates plant cell wall-degrading enzymes	loss of pathogenicity_reduced virulence	Gene deletion: full; gene complementation	23113713
C1_04362	CAD00690	41.5	427	7	236	16	434	11	431	5.36e-106	319.0	Q8Y448	PHI:5257	secY	1639	PHI:5356_PHI:5355	Listeria monocytogenes	10403S	listeriosis	Rodents	10090	Mus musculus (related: house mouse)	Protein translocase subunit SecY	increased virulence (hypervirulence)	Gene mutation	25535272
C1_04372	CAE43883	76.4	123	1	28	1	123	1	122	6.37e-63	186.0	Q7VTC1	PHI:11120	rplN	520	nan	Bordetella pertussis	Tohama I	pertussis	Rodents_Primates	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	50S ribosomal protein	unaffected pathogenicity_increased virulence (hypervirulence)	Gene mutation	33293402
C1_04379	FGSG_01290	47.3	300	8	119	7	268	59	357	6.04e-74	229.0	I1RCH5	PHI:1569	GzOB009	5518	nan	Fusarium graminearum	GZ3639	fusarium ear blight	Monocots	4564	Triticum (related: wheat)	transcription factor	lethal	Gene deletion	22028654
C1_04385	AAK88486	49.0	151	0	77	1	151	9	159	7.97e-45	143.0	Q7CWA3	PHI:10827	bfr (atu2771)	358	nan	Agrobacterium tumefaciens	C58	crown gall	Eudicots	4113_23013	Solanum tuberosum (related: potato)_Kalanchoe daigremontiana (related: devil's backbone)	Bacterioferritin	reduced virulence	Gene deletion: full; gene complementation	32678502
C1_04389	AAC43331	98.1	206	0	4	1	206	1	206	6.68e-153	420.0	P43019	PHI:11376	sodA	28901	PHI:11377_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028	salmonellosis	Moths	7137	Galleria mellonella (related: greater wax moth)	Cytoplasmic superoxide dismutase	reduced virulence	Gene deletion: full	33732665
C1_04405	AAB03027	99.9	804	0	1	1	804	213	1016	0.0	1675.0	P32176	PHI:10994	fdoG	562	nan	Escherichia coli	PCN033	infection	Rodents	10090	Mus musculus (related: house mouse)	Formate dehydrogenase-O major subunit	unaffected pathogenicity	Gene deletion: full	32962530
C1_04420	ADD55082	44.0	50	0	28	34	83	134	183	3.26e-07	46.2	D3QJB2	PHI:3526	lacA	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	lactose negativity	reduced virulence	Altered gene expression / gene regulation: overexpression	25362512
C1_04427	ACY88406	87.2	468	0	60	1	468	1	468	1.62e-293	798.0	A0A0F6B1M0	PHI:7225	ydcR	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain SL1344	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Putative transcriptional regulator	reduced virulence	Gene deletion: full; gene complementation	28674150
C1_04445	CCP43852	42.8	325	2	172	3	326	31	342	1.16e-86	263.0	P9WN21	PHI:6486_PHI:6487	GPM2_GLPX	1773	PHI:6487_PHI:6486_nan	Mycobacterium tuberculosis	H37Rv	tuberculosis	Rodents	10090	Mus musculus (related: house mouse)	Fructose bisphosphatase	loss of pathogenicity_unaffected pathogenicity	Gene deletion: full; gene complementation	26258286
C1_04454	CBA19050	87.8	320	0	39	1	320	1	320	9.7e-212	578.0	D4HUC7	PHI:9309	pfkA	552	nan	Erwinia amylovora	HKN06P1	fire blight	Eudicots	3750	Malus domestica (related: apple)	ATP-dependent 6-phosphofructokinase	reduced virulence	Gene mutation	31152019
C1_04456	CBG90541	88.6	166	0	19	1	166	1	166	1.26e-92	265.0	D2TU75	PHI:8515	cpxP	67825	PHI:8514_nan	Citrobacter rodentium	DBS100	colitis	Rodents	10090	Mus musculus (related: house mouse)	Periplasmic protein	unaffected pathogenicity	Gene deletion: full	30280092
C1_04457	AAC36868_AAC76894	100.0	232	0	0	1	232	1	232	1.68e-168	462.0	P0AE88	PHI:9363_PHI:8273_PHI:4523	cpxR_CpxR	562	nan_PHI:8272	Escherichia coli	serotype O2:K1 strain DE719_UTI89_serotype O2:K1:H7 strain M78	urinary tract infection_avian colibacillosis	Birds_Primates_Rodents	8839_9031_10090_9606	Homo sapiens (related: human)_Gallus gallus (related: chicken)_Anas platyrhynchos (related: mallard)_Mus musculus (related: house mouse)	response regulator (CpxR)-sensor kinase_Cytoplasmic transcriptional regulator_Two-component regulatory system response regulator	reduced virulence_unaffected pathogenicity	Gene deletion: full; gene complementation_Gene mutation; gene complementation	31126325_30062827_25675528
C1_04458	CBG90543	98.5	457	0	7	1	457	1	457	0.0	877.0	D2TU77	PHI:8513_PHI:8689	cpxA	67825	PHI:8688_PHI:8690; PHI:8688_PHI:8512_nan	Citrobacter rodentium	DBS100	colitis	Rodents	10090	Mus musculus (related: house mouse)	Two-component sensor kinase	loss of pathogenicity_reduced virulence_unaffected pathogenicity	Gene deletion: full; gene complementation	30536519_30280092
C1_04485	CAV17749	49.6	839	5	413	1	832	116	951	2.6400000000000003e-259	745.0	B7VKI8	PHI:5275	copA	212663	nan	Vibrio tasmaniensis	LGP32	nan	Bivalves	29159	Crassostrea gigas (related: pacific oyster)	Copper homeostasis	reduced virulence	Gene deletion: full; gene complementation	26472275
C1_04517	AAD21081	41.7	120	0	70	116	235	186	305	5.94e-23	93.6	E1WAC0	PHI:11724	hilD	28901	nan_PHI:11723	Salmonella enterica	subsp. enterica serovar Typhimurium strain SL1344	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	Transcriptional regulator 	unaffected pathogenicity	Gene deletion: full; gene complementation	34048498
C1_04518	AAC45084	57.7	317	1	132	1	317	1	315	9.93e-133	378.0	O33641	PHI:6577	IcsP	623	nan	Shigella flexneri	M90T	shigellosis	Rodents	10090	Mus musculus (related: house mouse)	Outer membrane protease	reduced virulence	Gene deletion: full; gene complementation	26025071
C1_04519	AAL21747	40.2	102	0	61	143	244	189	290	9.32e-20	84.7	P0CL09	PHI:631	hilC	28901	nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain SL1344	gastroenteritis	Rodents	10090	Mus musculus (related: house mouse)	nan	reduced virulence	Other evidence	16113260
C1_04535	AAL22939	98.1	105	0	2	1	105	1	105	6.200000000000001e-73	210.0	P06203	PHI:9083	metJ	28901	PHI:9084_nan	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028	salmonellosis	Primates_Rodents	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Master repressor of the methionine regulon	reduced virulence	Gene mutation	29866910
C1_04536	ADM96414	86.0	385	0	54	1	385	1	385	2.15e-239	654.0	E0SGC8	PHI:8570	metB (Dda3937_03888)	204038	nan	Dickeya dadantii	3937	soft rot	Eudicots	13427	Cichorium intybus (related: chicory)	Cystathionine gamma-synthase	reduced virulence	Gene deletion: full	30267562
C1_04538	CBA19083	87.2	296	0	38	1	296	1	296	2.24e-197	540.0	D4HUG0	PHI:9325	metF	552	nan	Erwinia amylovora	HKN06P1	fire blight	Eudicots	3750	Malus domestica (related: apple)	Methylenetetrahydrofolate reductase	unaffected pathogenicity	Gene mutation	31152019
C1_04539	AAL22946	92.0	725	0	58	1	725	1	725	0.0	1361.0	P17750	PHI:11381	katG	28901	PHI:11380; PHI:11382	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028	salmonellosis	Moths	7137	Galleria mellonella (related: greater wax moth)	Catalase	reduced virulence	Gene deletion: full	33732665
C1_04545	CAD5309993	92.2	886	0	69	1	886	1	886	0.0	1615.0	A0A0D6F9C4	PHI:123169	pat	28901	PHI:123168	Salmonella enterica	subsp. enterica serovar Typhimurium strain ATCC 14028s	salmonellosis	Rodents	10090	Mus musculus (related: house mouse)	phosphate acetyltransferase	loss of pathogenicity_reduced virulence	Gene deletion: full	35622226
C1_04558	CBA22840	43.5	69	1	37	2	68	447	515	8.32e-11	58.5	D4I0P2	PHI:7391_PHI:7109	EAMY _3003_vgrG-3	552	PHI:7392; PHI:7393; PHI:7394; PHI:7395; PHI:7396; PHI:7397; PHI:7398; PHI:7399; PHI:7400; PHI:7401; PHI:7402; PHI:7403; PHI:7404; PHI:7405; PHI:7406; PHI:7407; PHI:7408; PHI:7409; PHI:7410; PHI:7411; PHI:7412; PHI:7413; PHI:7414; PHI:7415; PHI:7416; PHI:7417; PHI:7418; PHI:7419; PHI:7420; PHI:7421; PHI:7422; PHI:7423; PHI:7424; PHI:7425; PHI:7426; PHI:7427; PHI:7428; PHI:7429; PHI:7430; PHI:7431; PHI:7432; PHI:7433; PHI:7434; PHI:7435; PHI:7436; PHI:7437; PHI:7438; PHI:7439; PHI:7440; PHI:7441; PHI:7442; PHI:7443; PHI:7444_nan_PHI:7392; PHI:7393; PHI:7394; PHI:7395; PHI:7396; PHI:7397; PHI:7398; PHI:7399; PHI:7400; PHI:7401; PHI:7402; PHI:7403; PHI:7404; PHI:7405; PHI:7406; PHI:7407; PHI:7408; PHI:7409; PHI:7410; PHI:7411; PHI:7412; PHI:7413; PHI:7414; PHI:7415; PHI:7416	Erwinia amylovora	CFBP 1430_NCPPB 1665	fire blight	Eudicots	3750_23211	Malus domestica (related: apple)_Pyrus communis (related: pear)	Putative type VI secretion system, effector protein_T6SS Effector protein	reduced virulence_unaffected pathogenicity_effector (plant avirulence determinant)_increased virulence (hypervirulence)	Gene deletion: full_Gene mutation; gene complementation	28818038_28421913
C1_04559	AAD07906	40.6	160	2	87	7	165	6	158	1.76e-37	126.0	O25531	PHI:11747	HP0860 (GmhB)	210	nan	Helicobacter pylori	26695	chronic gastritis	Primates	9606	Homo sapiens (related: human)	D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase	reduced virulence	Gene deletion: full; gene complementation	34125649
C1_04561	AIK76292	46.4	151	1	80	15	165	29	178	1.7900000000000002e-33	118.0	R4ZAR0	PHI:11570	metP	1311	nan	Streptococcus agalactiae	group B serotype V strain CNCTC 10/84	group b streptococcal infection	Primates	9606	Homo sapiens (related: human)	Methionine permease	reduced virulence	Gene deletion: full; gene complementation	32747604
C1_04587	no data found	43.1	102	3	53	147	246	1148	1246	3.91e-18	85.1	A0A1B2RBP7	PHI:11588	PPECC33_0249 (Rhs1)	562	nan	Escherichia coli	PCN033	infection	Rodents_Primates	10090_9606	Homo sapiens (related: human)_Mus musculus (related: house mouse)	Classic rearrangement hotspot protein	reduced virulence	Gene deletion: full; gene complementation	34382147