query_name Ko_name KEGG_Pathway KEGG_ko EC Ko_DEC level3_name:level2_name:level1_name Z1_00001 ko01503,map01503 ko:K01406 3.4.24.40 Serine 3-dehydrogenase Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases Z1_00002 prtD ko02010,map02010 ko:K12536 alkaline protease (AprA) secretion protein AprD ABC transporters : Membrane transport : Environmental Information Processing Z1_00003 aprE ko:K02022,ko:K12534,ko:K12537,ko:K16300 Type I secretion membrane fusion protein, HlyD NA Z1_00004 lipD ko:K12538 Outer membrane efflux protein NA Z1_00005 arnT ko01503,map01503 ko:K07264 2.4.2.43 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases Z1_00006 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 ko:K01607 4.1.1.44 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity Benzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Degradation of aromatic compounds : Global and overview maps : Metabolism Z1_00008 ydaH ko:K12942 AbgT putative transporter family NA Z1_00012 yfcQ ko:K12521 Fimbrial protein NA Z1_00013 ko:K12521 Fimbrial protein NA Z1_00014 yfcS ko:K07346,ko:K12519 Pili assembly chaperone PapD, C-terminal domain NA Z1_00016 ko05133,map05133 ko:K07345,ko:K12517 Fimbrial Pertussis : Infectious disease: bacterial : Human Diseases Z1_00017 mrpA ko05133,map05133 ko:K07345,ko:K12517 Fimbrial protein Pertussis : Infectious disease: bacterial : Human Diseases Z1_00018 ko:K04763,ko:K07357,ko:K07358 Phage integrase family NA Z1_00022 yfcQ ko:K12521 Fimbrial protein NA Z1_00023 ko:K12521 Fimbrial protein NA Z1_00026 ko05133,map05133 ko:K07345,ko:K12517 Fimbrial protein Pertussis : Infectious disease: bacterial : Human Diseases Z1_00027 rnz ko03013,map03013 ko:K00784 3.1.26.11 ribonuclease Z RNA transport : Translation : Genetic Information Processing Z1_00029 ko:K03646 Membrane NA Z1_00030 betT ko:K02168 Belongs to the BCCT transporter (TC 2.A.15) family NA Z1_00033 hpaC ko00350,ko00740,ko01100,ko01120,ko01220,map00350,map00740,map01100,map01120,map01220 ko:K00484 1.5.1.36 Flavin reductase like domain Tyrosine metabolism : Amino acid metabolism : Metabolism;Riboflavin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Degradation of aromatic compounds : Global and overview maps : Metabolism Z1_00034 dtpB ko:K03305 Proton-dependent permease that transports di- and tripeptides NA Z1_00036 fbaA ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 ko:K01624 4.1.2.13 Fructose-bisphosphate aldolase class-II Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_00037 pgk ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 ko:K00927,ko:K01803 2.7.2.3,5.3.1.1 Phosphoglycerate kinase Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Inositol phosphate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_00038 epd ko00010,ko00710,ko00750,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map00750,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 ko:K00134,ko:K03472 1.2.1.12,1.2.1.72 Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Vitamin B6 metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism;HIF-1 signaling pathway : Signal transduction : Environmental Information Processing;Alzheimer disease : Neurodegenerative disease : Human Diseases Z1_00041 ko02010,map02010 ko:K02016 Periplasmic binding protein ABC transporters : Membrane transport : Environmental Information Processing Z1_00042 ko:K05820,ko:K08161 Major facilitator Superfamily NA Z1_00043 odh ko:K04940 1.5.1.28 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain NA Z1_00044 cbs ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230 ko:K01697 4.2.1.22 Pyridoxal-phosphate dependent enzyme Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_00045 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 ko:K01586 4.1.1.20 decarboxylase Lysine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_00046 fcuA ko:K02014 receptor NA Z1_00048 ko00660,ko01100,ko02020,map00660,map01100,map02020 ko:K01644,ko:K18292 4.1.3.25,4.1.3.34 Belongs to the HpcH HpaI aldolase family C5-Branched dibasic acid metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing Z1_00049 fhuC_1 ko02010,map02010 ko:K02013 3.6.3.34 AAA domain, putative AbiEii toxin, Type IV TA system ABC transporters : Membrane transport : Environmental Information Processing Z1_00050 irp6B ko02010,map02010 ko:K02015 ABC 3 transport family ABC transporters : Membrane transport : Environmental Information Processing Z1_00054 ko:K21966 Psort location OuterMembrane, score NA Z1_00057 dnaQ ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 ko:K02342,ko:K14159 2.7.7.7,3.1.26.4 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;DNA replication : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing Z1_00058 rnhA ko03030,map03030 ko:K03469 3.1.26.4 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids DNA replication : Replication and repair : Genetic Information Processing Z1_00060 gloB ko00620,map00620 ko:K01069 3.1.2.6 Hydroxyacylglutathione hydrolase Pyruvate metabolism : Carbohydrate metabolism : Metabolism Z1_00061 mltD ko:K08307,ko:K12204 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) NA Z1_00065 pyrG ko00240,ko01100,map00240,map01100 ko:K01937 6.3.4.2 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00066 mazG ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100 ko:K02428,ko:K02499,ko:K04765 3.6.1.66,3.6.1.9 MazG nucleotide pyrophosphohydrolase domain Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00067 relA ko00230,map00230 ko:K00951,ko:K01139 2.7.6.5,3.1.7.2 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance Purine metabolism : Nucleotide metabolism : Metabolism Z1_00068 rlmD ko:K03215 2.1.1.190 Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA NA Z1_00069 dgt ko00230,map00230 ko:K01129 3.1.5.1 dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs Purine metabolism : Nucleotide metabolism : Metabolism Z1_00070 mtnN ko00270,ko01100,ko01230,map00270,map01100,map01230 ko:K01243 3.2.2.9 Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_00071 btuF ko02010,map02010 ko:K02016,ko:K06858 Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC ABC transporters : Membrane transport : Environmental Information Processing Z1_00072 erpA ko:K13628,ko:K15724 Iron-sulphur cluster biosynthesis NA Z1_00073 hemL ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 ko:K01845 5.4.3.8 Aminotransferase class-III Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_00074 mrcB ko00550,map00550 ko:K03814,ko:K05365 2.4.1.129,3.4.16.4 Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism Z1_00075 hrpB ko:K03579 3.6.4.13 ATP-dependent helicase C-terminal NA Z1_00076 sfsA ko:K06206 Sugar fermentation stimulation protein NA Z1_00077 dksA ko02026,map02026 ko:K06204 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes Z1_00079 pcnB ko03013,ko03018,map03013,map03018 ko:K00970,ko:K00974 2.7.7.19,2.7.7.72 Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control RNA transport : Translation : Genetic Information Processing;RNA degradation : Folding, sorting and degradation : Genetic Information Processing Z1_00080 folK ko00790,ko01100,map00790,map01100 ko:K00950,ko:K13940 2.7.6.3,4.1.2.25 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00081 panB ko00770,ko01100,ko01110,map00770,map01100,map01110 ko:K00606 2.1.2.11 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_00082 panC ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 ko:K01918 6.3.2.1 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate beta-Alanine metabolism : Metabolism of other amino acids : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_00084 uhpA ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 ko:K02282,ko:K07686,ko:K07687,ko:K07689,ko:K20264 helix_turn_helix, Lux Regulon Two-component system : Signal transduction : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes Z1_00085 uhpB ko02020,ko02024,map02020,map02024 ko:K07675,ko:K14988,ko:K20263 2.7.13.3 two-component sensor histidine kinase UhpB, phosphorylates UhpA K07675 Two-component system : Signal transduction : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_00086 uhpC ko02020,map02020 ko:K02445,ko:K07783 Major Facilitator Superfamily Two-component system : Signal transduction : Environmental Information Processing Z1_00087 afuA ko02010,map02010 ko:K02012 Bacterial extracellular solute-binding protein ABC transporters : Membrane transport : Environmental Information Processing Z1_00088 afuB ko02010,map02010 ko:K02011 transport system permease ABC transporters : Membrane transport : Environmental Information Processing Z1_00089 fbpC ko02010,map02010 ko:K02010 3.6.3.30 Part of the ABC transporter complex FbpABC involved in Fe(3 ) ions import. Responsible for energy coupling to the transport system ABC transporters : Membrane transport : Environmental Information Processing Z1_00090 dsdA ko00260,map00260 ko:K01753 4.3.1.18 Pyridoxal-phosphate dependent enzyme Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism Z1_00091 dsdX ko:K03299,ko:K13629 GntP family permease NA Z1_00092 dsdC ko:K13636 Bacterial regulatory helix-turn-helix protein, lysR family NA Z1_00093 gsp ko00480,ko01100,map00480,map01100 ko:K01460 3.5.1.78,6.3.1.8 Glutathionylspermidine synthase preATP-grasp Glutathione metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00096 ko02025,ko03070,map02025,map03070 ko:K06887,ko:K11903 type VI secretion system effector, Hcp1 family Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes;Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_00099 efeU ko:K07243 Iron permease FTR1 family NA Z1_00100 efeO ko:K07224,ko:K07243 periplasmic lipoprotein involved in iron transport NA Z1_00101 efeB ko:K16301 Dyp-type peroxidase family NA Z1_00104 ko00920,map00920 ko:K07307 4Fe-4S binding domain Sulfur metabolism : Energy metabolism : Metabolism Z1_00105 ko00920,map00920 ko:K07308,ko:K07312 DMSO reductase anchor subunit (DmsC) Sulfur metabolism : Energy metabolism : Metabolism Z1_00106 lemA ko:K03744 LemA family NA Z1_00107 htpX ko:K03799 Peptidase family M48 NA Z1_00109 yceI ko:K08369 Uncharacterised MFS-type transporter YbfB NA Z1_00110 yadH ko:K01992 ABC-2 type transporter NA Z1_00111 yadG ko02010,map02010 ko:K01990,ko:K09695 (ABC) transporter ABC transporters : Membrane transport : Environmental Information Processing Z1_00112 can ko00910,map00910 ko:K01673 4.2.1.1 Reversible hydration of carbon dioxide Nitrogen metabolism : Energy metabolism : Metabolism Z1_00114 cueO ko:K04753,ko:K14588 Multi-copper NA Z1_00116 yhjN ko:K07120 Pfam:AmoA NA Z1_00123 dapB ko00300,ko00310,ko00330,ko00472,ko01100,ko01110,ko01230,map00300,map00310,map00330,map00472,map01100,map01110,map01230 ko:K03340,ko:K21672 1.4.1.12,1.4.1.16,1.4.1.26 Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate Lysine biosynthesis : Amino acid metabolism : Metabolism;Lysine degradation : Amino acid metabolism : Metabolism;Arginine and proline metabolism : Amino acid metabolism : Metabolism;D-Arginine and D-ornithine metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_00124 yisQ ko:K03327 MatE NA Z1_00126 pepT ko:K01258 3.4.11.4 Cleaves the N-terminal amino acid of tripeptides NA Z1_00127 dcuD_1 ko:K03326 C4-dicarboxylate anaerobic carrier NA Z1_00131 cstA ko:K06200 5TM C-terminal transporter carbon starvation CstA NA Z1_00132 recR ko03440,map03440 ko:K06187 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO Homologous recombination : Replication and repair : Genetic Information Processing Z1_00133 ybaB ko03440,map03440 ko:K06187,ko:K09747 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection Homologous recombination : Replication and repair : Genetic Information Processing Z1_00134 dnaX ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 ko:K02343 2.7.7.7 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;DNA replication : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing Z1_00135 apt ko00230,ko01100,map00230,map01100 ko:K00759 2.4.2.7 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis Purine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00137 priC ko03440,map03440 ko:K04067 Primosomal replication protein priC Homologous recombination : Replication and repair : Genetic Information Processing Z1_00139 kefA ko02010,map02010 ko:K05802,ko:K06994,ko:K15771,ko:K22051 Mechanosensitive ion channel ABC transporters : Membrane transport : Environmental Information Processing Z1_00140 ychN ko:K06039 DsrE/DsrF-like family NA Z1_00141 acrR ko:K03577 MAATS-type transcriptional repressor, C-terminal region NA Z1_00142 acrA ko01501,ko01503,map01501,map01503 ko:K03585 Barrel-sandwich domain of CusB or HlyD membrane-fusion beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases Z1_00143 acrB ko01501,ko01503,map01501,map01503 ko:K18138 AcrB/AcrD/AcrF family beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases Z1_00144 tomB ko:K19162 Biofilm formation regulator YbaJ NA Z1_00145 hha ko:K05839 Haemolysin expression modulating protein NA Z1_00147 tesB ko01040,map01040 ko:K10805 acyl-CoA thioesterase II Biosynthesis of unsaturated fatty acids : Lipid metabolism : Metabolism Z1_00148 amtB ko:K03320 Ammonium Transporter Family NA Z1_00149 glnK ko02020,map02020 ko:K04751,ko:K04752 Nitrogen regulatory protein P-II Two-component system : Signal transduction : Environmental Information Processing Z1_00150 mdlB ko02010,map02010 ko:K06147,ko:K18890 ABC transporter ABC transporters : Membrane transport : Environmental Information Processing Z1_00151 mdlA ko02010,map02010 ko:K06148,ko:K18889 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation ABC transporters : Membrane transport : Environmental Information Processing Z1_00152 ybaO ko:K03719,ko:K05800 helix_turn_helix ASNC type NA Z1_00153 queC ko00790,ko01100,map00790,map01100 ko:K06920 6.3.4.20 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00154 tesC ko:K07107,ko:K12500 Acyl-ACP thioesterase NA Z1_00155 comEA ko:K02237 Helix-hairpin-helix motif NA Z1_00156 ppiD ko:K01802,ko:K03769,ko:K03770 5.2.1.8 peptidylprolyl isomerase NA Z1_00157 hupB ko:K03530 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions NA Z1_00158 lon ko04112,map04112 ko:K01338 3.4.21.53 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner Cell cycle - Caulobacter : Cell growth and death : Cellular Processes Z1_00159 clpX ko04112,map04112 ko:K03544 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP Cell cycle - Caulobacter : Cell growth and death : Cellular Processes Z1_00160 clpP ko04112,ko04212,map04112,map04212 ko:K01358 3.4.21.92 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins Cell cycle - Caulobacter : Cell growth and death : Cellular Processes;Longevity regulating pathway - worm : Aging : Organismal Systems Z1_00161 tig ko:K03545 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase NA Z1_00162 bolA ko:K05527,ko:K22066 BolA-like protein NA Z1_00163 yajG ko:K07286 Uncharacterized lipoprotein NA Z1_00164 ampG ko01501,map01501 ko:K08218 Acetyl-coenzyme A transporter 1 beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases Z1_00165 dbpA ko03018,map03018 ko:K05591,ko:K05592 3.6.4.13 DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes RNA degradation : Folding, sorting and degradation : Genetic Information Processing Z1_00167 cyoA ko00190,ko01100,map00190,map01100 ko:K02297,ko:K02826 1.10.3.10,1.10.3.12 Cytochrome C oxidase subunit II, transmembrane domain Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00168 cyoB ko00190,ko01100,map00190,map01100 ko:K02274,ko:K02298,ko:K02827 1.10.3.10,1.10.3.12,1.9.3.1 Belongs to the heme-copper respiratory oxidase family Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00169 cyoC ko00190,ko01100,map00190,map01100 ko:K02299 cytochrome o ubiquinol oxidase, subunit III Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00172 yajQ ko:K09767 Protein of unknown function (DUF520) NA Z1_00173 panE ko00770,ko01100,ko01110,map00770,map01100,map01110 ko:K00077 1.1.1.169 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_00174 thiJ ko05012,map05012 ko:K03152,ko:K05520,ko:K05687,ko:K12132 2.7.11.1,3.5.1.124 DJ-1/PfpI family Parkinson disease : Neurodegenerative disease : Human Diseases Z1_00176 ko:K19160 Toxin YafO, type II toxin-antitoxin system NA Z1_00177 thiI ko00730,ko01100,ko04122,map00730,map01100,map04122 ko:K03151 2.8.1.4 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS Thiamine metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing Z1_00178 xseB ko03430,map03430 ko:K03602 3.1.11.6 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides Mismatch repair : Replication and repair : Genetic Information Processing Z1_00179 ispA ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 ko:K00795,ko:K02523,ko:K13789 2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90 Polyprenyl synthetase Terpenoid backbone biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA Z1_00180 dxs ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 ko:K01662 2.2.1.7 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) Thiamine metabolism : Metabolism of cofactors and vitamins : Metabolism;Terpenoid backbone biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA Z1_00181 rbsD ko02010,map02010 ko:K06726 5.4.99.62 Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose ABC transporters : Membrane transport : Environmental Information Processing Z1_00182 rbsA ko02010,map02010 ko:K10441,ko:K10542 3.6.3.17 Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system ABC transporters : Membrane transport : Environmental Information Processing Z1_00183 rbsC ko02010,map02010 ko:K03549,ko:K10440 Branched-chain amino acid transport system / permease component ABC transporters : Membrane transport : Environmental Information Processing Z1_00184 rbsB ko02010,ko02030,map02010,map02030 ko:K02058,ko:K10439 Periplasmic binding protein ABC transporters : Membrane transport : Environmental Information Processing;Bacterial chemotaxis : Cell motility : Cellular Processes Z1_00185 rbsK ko00030,map00030 ko:K00852 2.7.1.15 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway Pentose phosphate pathway : Carbohydrate metabolism : Metabolism Z1_00186 rbsR ko:K02529,ko:K03604 Periplasmic binding proteins and sugar binding domain of LacI family NA Z1_00187 phnA ko01120,map01120 ko:K06193 PhnA Zinc-Ribbon Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_00188 thiL ko00730,ko01100,map00730,map01100 ko:K00946 2.7.4.16 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 Thiamine metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00189 nusB ko:K03625 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons NA Z1_00190 ribH ko00740,ko01100,ko01110,map00740,map01100,map01110 ko:K00794 2.5.1.78 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin Riboflavin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_00191 ribD ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 ko:K11752 1.1.1.193,3.5.4.26 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate Riboflavin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_00192 nrdR ko:K07738 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes NA Z1_00193 secF ko02024,ko03060,ko03070,map02024,map03060,map03070 ko:K03072,ko:K03074,ko:K12257 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Protein export : Folding, sorting and degradation : Genetic Information Processing;Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_00194 secD ko03060,ko03070,map03060,map03070 ko:K03072 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA Protein export : Folding, sorting and degradation : Genetic Information Processing;Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_00195 yajC ko02024,ko03060,ko03070,map02024,map03060,map03070 ko:K03210 Preprotein translocase subunit Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Protein export : Folding, sorting and degradation : Genetic Information Processing;Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_00196 tgt ko:K00773 2.4.2.29 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) NA Z1_00197 queA ko:K00773,ko:K07568 2.4.2.29,2.4.99.17 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) NA Z1_00198 acpH ko00770,map00770 ko:K08682 3.1.4.14 Acyl carrier protein phosphodiesterase Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism Z1_00199 ahpC ko04214,map04214 ko:K03386,ko:K20011 1.11.1.15 C-terminal domain of 1-Cys peroxiredoxin Apoptosis - fly : Cell growth and death : Cellular Processes Z1_00200 ggt ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 ko:K00681 2.3.2.2,3.4.19.13 Gamma-glutamyltranspeptidase Taurine and hypotaurine metabolism : Metabolism of other amino acids : Metabolism;Cyanoamino acid metabolism : Metabolism of other amino acids : Metabolism;Glutathione metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00202 ydhV ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 ko:K03738 1.2.7.5 Aldehyde ferredoxin oxidoreductase, N-terminal domain Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism Z1_00204 ydhX ko00920,ko01120,ko02020,map00920,map01120,map02020 ko:K08353,ko:K08358 4Fe-4S binding domain Sulfur metabolism : Energy metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing Z1_00205 ydhU ko00920,ko01120,ko02020,map00920,map01120,map02020 ko:K03620,ko:K08354 Prokaryotic cytochrome b561 Sulfur metabolism : Energy metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing Z1_00210 MA20_05215 ko:K15773 Helix-turn-helix XRE-family like proteins NA Z1_00211 hipA ko:K07154 2.7.11.1 Pfam:HipA_N NA Z1_00212 brnQ ko:K03311 Component of the transport system for branched-chain amino acids NA Z1_00213 phoR ko02020,map02020 ko:K02484,ko:K07636 2.7.13.3 Domain of unknown function (DUF3329) Two-component system : Signal transduction : Environmental Information Processing Z1_00215 sbcD ko:K03547 SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity NA Z1_00216 sbcC ko:K03546 exonuclease NA Z1_00217 ko:K07078 Nitroreductase family NA Z1_00218 ko:K06218 ParE-like toxin of type II bacterial toxin-antitoxin system NA Z1_00220 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 ko:K01081,ko:K19970 3.1.3.5 Belongs to the 5'-nucleotidase family Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_00221 rns ko:K01166 3.1.27.1 Ribonuclease T2 family NA Z1_00222 cpdB ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 ko:K01119,ko:K08693 3.1.3.5,3.1.3.6,3.1.4.16 2',3'-cyclic-nucleotide 2'-phosphodiesterase Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_00223 ompH ko05111,map05111 ko:K10940,ko:K11929 Gram-negative porin Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes Z1_00224 rdgC ko:K03554 May be involved in recombination NA Z1_00225 yedF ko04122,map04122 ko:K04085 Sulfurtransferase TusA Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing Z1_00226 yedE ko:K07112 Sulphur transport NA Z1_00227 hypE ko:K04655 AIR synthase related protein, N-terminal domain NA Z1_00228 hypD ko:K04654 Hydrogenase formation hypA family NA Z1_00229 hupF ko:K03605,ko:K03618,ko:K04653 HupF/HypC family NA Z1_00230 hypB ko:K03189,ko:K04652 hydrogenase accessory protein NA Z1_00232 hybD ko:K03605,ko:K08315 3.4.23.51 Hydrogenase maturation protease NA Z1_00233 hybC ko00633,ko01120,map00633,map01120 ko:K06281 1.12.99.6 Nickel-dependent hydrogenase Nitrotoluene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_00235 hybA ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 ko:K00124 4Fe-4S dicluster domain Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism Z1_00236 hybO ko00633,ko01120,map00633,map01120 ko:K06282,ko:K18008 1.12.2.1,1.12.99.6 NADH ubiquinone oxidoreductase, 20 Kd subunit Nitrotoluene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_00239 exbD ko:K03559,ko:K03560 Biopolymer transport protein ExbD/TolR NA Z1_00240 exbB ko01120,map01120 ko:K03561,ko:K03562 MotA/TolQ/ExbB proton channel family Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_00241 metC ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 ko:K01739,ko:K01760,ko:K01761 2.5.1.48,4.4.1.11,4.4.1.8 cystathionine beta-lyase (CHL) (beta-cystathionase) (cysteine lyase) K01760 Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_00243 yqhD ko00640,ko00650,ko01120,map00640,map00650,map01120 ko:K00100,ko:K08325,ko:K19955 Iron-containing alcohol dehydrogenase Propanoate metabolism : Carbohydrate metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_00244 dkgA ko:K06221 1.1.1.346 Aldo/keto reductase family NA Z1_00245 ratA ko00500,ko00550,ko01100,ko01502,ko02020,ko05100,map00500,map00550,map01100,map01502,map02020,map05100 ko:K01179,ko:K01449,ko:K07260,ko:K13735 3.2.1.4,3.4.17.14,3.5.1.28 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Vancomycin resistance : Drug resistance: antimicrobial : Human Diseases;Two-component system : Signal transduction : Environmental Information Processing;Bacterial invasion of epithelial cells : Infectious disease: bacterial : Human Diseases Z1_00246 carB ko00240,ko00250,ko01100,map00240,map00250,map01100 ko:K01955 6.3.5.5 carbamoyl-phosphate synthase large Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00247 carA ko00240,ko00250,ko01100,map00240,map00250,map01100 ko:K01956 6.3.5.5 Glutamine amidotransferase class-I Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00248 dapB ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 ko:K00215,ko:K03546 1.17.1.8 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate Monobactam biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Lysine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_00249 ispH ko00240,ko00900,ko01100,ko01110,ko01130,ko03010,map00240,map00900,map01100,map01110,map01130,map03010 ko:K00945,ko:K02945,ko:K03527 1.17.7.4,2.7.4.25 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Terpenoid backbone biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Ribosome : Translation : Genetic Information Processing Z1_00250 fkpB ko:K03774,ko:K03775 5.2.1.8 FKBP-type peptidyl-prolyl cis-trans isomerase NA Z1_00251 lspA ko03060,map03060 ko:K03101 3.4.23.36 This protein specifically catalyzes the removal of signal peptides from prolipoproteins Protein export : Folding, sorting and degradation : Genetic Information Processing Z1_00252 ileS ko00970,map00970 ko:K01870 6.1.1.5 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing Z1_00253 ribF ko00740,ko01100,ko01110,map00740,map01100,map01110 ko:K11753 2.7.1.26,2.7.7.2 FAD synthetase Riboflavin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_00254 rpsT ko03010,map03010 ko:K02968 Binds directly to 16S ribosomal RNA Ribosome : Translation : Genetic Information Processing Z1_00255 nhaR ko:K03717 Bacterial regulatory helix-turn-helix protein, lysR family NA Z1_00256 nhaA ko:K03313 Na( ) H( ) antiporter that extrudes sodium in exchange for external protons NA Z1_00257 dnaJ ko:K03686 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins NA Z1_00258 dnaK ko03018,ko04212,ko05152,map03018,map04212,map05152 ko:K04043 autoregulated heat shock proteins K04043 RNA degradation : Folding, sorting and degradation : Genetic Information Processing;Longevity regulating pathway - worm : Aging : Organismal Systems;Tuberculosis : Infectious disease: bacterial : Human Diseases Z1_00260 ko:K07126 Sel1-like repeats. NA Z1_00261 tal ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 ko:K00616,ko:K08314 2.2.1.2 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_00263 yaaA ko:K09861 Peroxide stress protein YaaA NA Z1_00266 thrB ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 ko:K00872 2.7.1.39 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_00267 thrA ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 ko:K00003,ko:K00928,ko:K12524,ko:K12525 1.1.1.3,2.7.2.4 belongs to the aspartokinase family Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Monobactam biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Lysine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_00269 creA ko:K05805 CreA protein NA Z1_00270 rob ko:K05804,ko:K13653 helix_turn_helix, arabinose operon control protein NA Z1_00271 gpmB ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 ko:K15634 5.4.2.12 Phosphoglycerate mutase family Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_00273 trpR ko:K03720 This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region NA Z1_00274 slt ko:K08309 Soluble lytic murein transglycosylase L domain NA Z1_00275 yjjK ko:K06020 3.6.3.25 ABC transporter NA Z1_00276 tonB ko:K03832 TonB C terminal NA Z1_00277 fecI ko:K03088 ECF sigma factor NA Z1_00278 ko:K07165 Domain of unknown function (DUF4880) NA Z1_00280 yddA ko02010,map02010 ko:K02471 SbmA/BacA-like family ABC transporters : Membrane transport : Environmental Information Processing Z1_00281 pqqL ko:K07263 Peptidase, M16 NA Z1_00282 ko:K15977 DoxX NA Z1_00283 fadH ko:K00219 1.3.1.34 2,4-dienoyl-CoA reductase NADPH (2,4-dienoyl coenzyme A reductase) K00219 NA Z1_00288 yqjD ko:K07184 Bacterial protein of unknown function (DUF883) NA Z1_00291 yqjF ko:K15977,ko:K18305 DoxX NA Z1_00292 yhaJ ko:K10972 Bacterial regulatory helix-turn-helix protein, lysR family NA Z1_00293 yhaK ko:K06911 Pirin NA Z1_00294 rsmI ko:K07056 2.1.1.198 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA NA Z1_00295 lpoA ko:K07121 LppC putative lipoprotein NA Z1_00296 yraN ko:K07460 Uncharacterised protein family UPF0102 NA Z1_00297 gmhA ko00540,ko00770,ko01100,map00540,map00770,map01100 ko:K03271,ko:K03272,ko:K03525,ko:K12961 2.7.1.167,2.7.1.33,2.7.7.70,5.3.1.28 SIS domain Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00299 ureG ko:K03189,ko:K04652 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG NA Z1_00300 ureF ko:K03188 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter NA Z1_00301 ureE ko:K03187 Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly NA Z1_00302 ureC ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120 ko:K01428 3.5.1.5 Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family Arginine biosynthesis : Amino acid metabolism : Metabolism;Purine metabolism : Nucleotide metabolism : Metabolism;Atrazine degradation : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Epithelial cell signaling in Helicobacter pylori infection : Infectious disease: bacterial : Human Diseases Z1_00303 ureB ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120 ko:K01427,ko:K01428,ko:K01429,ko:K14048 3.5.1.5 Urease beta subunit Arginine biosynthesis : Amino acid metabolism : Metabolism;Purine metabolism : Nucleotide metabolism : Metabolism;Atrazine degradation : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Epithelial cell signaling in Helicobacter pylori infection : Infectious disease: bacterial : Human Diseases Z1_00305 ureD ko:K03190 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter NA Z1_00307 mtgA ko00550,map00550 ko:K03814,ko:K05365 2.4.1.129,3.4.16.4 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism Z1_00309 arcB ko02020,ko02026,map02020,map02026 ko:K07648 2.7.13.3 Histidine kinase Two-component system : Signal transduction : Environmental Information Processing;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes Z1_00310 gltB ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 ko:K00265,ko:K00284 1.4.1.13,1.4.1.14,1.4.7.1 glutamate synthase NADPH large chain precursor (glutamate synthase alpha subunit) (NADPH-GOGAT) (GLTS alpha chain) K00265 Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Nitrogen metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_00311 gltD ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 ko:K00266 1.4.1.13,1.4.1.14 Flavin-binding monooxygenase-like Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Nitrogen metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_00312 ko:K03326 C4-dicarboxylate anaerobic carrier NA Z1_00313 abgA ko:K12940 Peptidase dimerisation domain NA Z1_00314 ko00860,ko01100,map00860,map01100 ko:K06042 5.4.99.60,5.4.99.61 transcriptional regulator Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00315 sspB ko:K03600,ko:K09985 Stringent starvation protein B NA Z1_00316 sspA ko:K03599 stringent starvation protein A NA Z1_00317 rpsI ko03010,map03010 ko:K02996 Ribosomal protein S9/S16 Ribosome : Translation : Genetic Information Processing Z1_00318 rplM ko03010,map03010 ko:K02871 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly Ribosome : Translation : Genetic Information Processing Z1_00319 zapE ko:K06916 Reduces the stability of FtsZ polymers in the presence of ATP NA Z1_00320 yhcB ko:K09908 Protein of unknown function (DUF1043) NA Z1_00321 degQ ko01503,ko02020,map01503,map02020 ko:K04771,ko:K04772,ko:K08070 1.3.1.74,3.4.21.107 Belongs to the peptidase S1C family Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases;Two-component system : Signal transduction : Environmental Information Processing Z1_00322 degS ko01503,ko02020,map01503,map02020 ko:K04691,ko:K04771,ko:K04772 3.4.21.107 Trypsin Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases;Two-component system : Signal transduction : Environmental Information Processing Z1_00326 murA ko00520,ko00550,ko01100,map00520,map00550,map01100 ko:K00790 2.5.1.7 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00327 yrbA ko:K07390 BolA-like protein NA Z1_00328 mlaB ko02010,map02010 ko:K02066,ko:K04749,ko:K07122 STAS domain ABC transporters : Membrane transport : Environmental Information Processing Z1_00329 ttg2D ko02010,map02010 ko:K07323 MlaC protein ABC transporters : Membrane transport : Environmental Information Processing Z1_00330 mlaD ko02010,map02010 ko:K02067 MlaD protein ABC transporters : Membrane transport : Environmental Information Processing Z1_00331 mlaE ko02010,map02010 ko:K02066 Permease MlaE ABC transporters : Membrane transport : Environmental Information Processing Z1_00332 mlaF ko02010,map02010 ko:K02065 ATPases associated with a variety of cellular activities ABC transporters : Membrane transport : Environmental Information Processing Z1_00333 Z012_08255 ko:K07301 Sodium/calcium exchanger protein NA Z1_00334 kdsD ko00540,ko01100,map00540,map01100 ko:K06041 5.3.1.13 Domain in cystathionine beta-synthase and other proteins. Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00335 kdsC ko00540,ko01100,map00540,map01100 ko:K03270 3.1.3.45 Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00336 lptC ko02010,ko02020,ko05152,map02010,map02020,map05152 ko:K02040,ko:K11719 Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA ABC transporters : Membrane transport : Environmental Information Processing;Two-component system : Signal transduction : Environmental Information Processing;Tuberculosis : Infectious disease: bacterial : Human Diseases Z1_00337 lptA ko:K09774 Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm NA Z1_00338 lptB ko02010,map02010 ko:K01990,ko:K06861 Branched-chain amino acid ATP-binding cassette transporter ABC transporters : Membrane transport : Environmental Information Processing Z1_00340 hpf ko:K05808,ko:K05809 Sigma 54 modulation protein / S30EA ribosomal protein NA Z1_00341 ptsN ko00051,ko00053,ko01100,ko01120,ko02060,map00051,map00053,map01100,map01120,map02060 ko:K02768,ko:K02769,ko:K02770,ko:K02806,ko:K02821 2.7.1.194,2.7.1.202 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing Z1_00343 ptsO ko00051,ko00561,ko01100,ko01120,ko02060,map00051,map00561,map01100,map01120,map02060 ko:K02768,ko:K02784,ko:K05881,ko:K08483,ko:K08485,ko:K11183,ko:K11189 2.7.1.121,2.7.1.202,2.7.3.9 PTS HPr component phosphorylation site Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Glycerolipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing Z1_00345 pmbA ko:K03592 Putative modulator of DNA gyrase NA Z1_00347 yhcO ko:K03623 Barstar (barnase inhibitor) NA Z1_00348 ko03018,ko05133,map03018,map05133 ko:K03628,ko:K15125 ribonuclease RNA degradation : Folding, sorting and degradation : Genetic Information Processing;Pertussis : Infectious disease: bacterial : Human Diseases Z1_00349 tldD ko:K03568 Putative modulator of DNA gyrase NA Z1_00350 ramA ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00380,map00460,map00627,map00643,map00910,map01120 ko:K01459,ko:K01501,ko:K11206 3.5.1.77,3.5.5.1 Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase Tryptophan metabolism : Amino acid metabolism : Metabolism;Cyanoamino acid metabolism : Metabolism of other amino acids : Metabolism;Aminobenzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Styrene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Nitrogen metabolism : Energy metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_00353 maf ko:K03215,ko:K06287 2.1.1.190 Maf-like protein NA Z1_00354 mreD ko:K03571 Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins NA Z1_00355 mreC ko:K03570 rod shape-determining protein MreC NA Z1_00357 yhdH ko00640,ko01100,map00640,map01100 ko:K19745 Zinc-binding dehydrogenase Propanoate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00358 aroQ ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 ko:K01271,ko:K03785,ko:K03786 3.4.13.9,4.2.1.10 Catalyzes a trans-dehydration via an enolate intermediate Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_00359 accB ko00010,ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00010,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 ko:K00627,ko:K02160 2.3.1.12 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Fatty acid biosynthesis : Lipid metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism Z1_00360 accC ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 ko:K01961 6.3.4.14,6.4.1.2 Biotin carboxylase C-terminal domain Fatty acid biosynthesis : Lipid metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism Z1_00362 panF ko:K03307,ko:K14392 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family NA Z1_00363 prmA ko:K02687 Ribosomal protein L11 methyltransferase NA Z1_00365 fis ko02020,ko05111,map02020,map05111 ko:K03557,ko:K07712 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters Two-component system : Signal transduction : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes Z1_00370 cynX ko:K03449 Major Facilitator Superfamily NA Z1_00373 ugpA ko02010,map02010 ko:K05814,ko:K15771 Binding-protein-dependent transport system inner membrane component ABC transporters : Membrane transport : Environmental Information Processing Z1_00374 ugpE ko02010,map02010 ko:K05815 probably responsible for the translocation of the substrate across the membrane ABC transporters : Membrane transport : Environmental Information Processing Z1_00376 ycaL ko:K07387 Peptidase family M48 NA Z1_00380 glxK ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130 ko:K00865 2.7.1.165 Glycerate kinase family Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Glycerolipid metabolism : Lipid metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA Z1_00381 rpoH ko:K03089 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes NA Z1_00382 ftsX ko02010,map02010 ko:K09811,ko:K09812 Part of the ABC transporter FtsEX involved in cellular division ABC transporters : Membrane transport : Environmental Information Processing Z1_00383 ftsE ko02010,map02010 ko:K09811,ko:K09812 ATPases associated with a variety of cellular activities ABC transporters : Membrane transport : Environmental Information Processing Z1_00384 ftsY ko02024,ko03060,ko03070,map02024,map03060,map03070 ko:K03110 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Protein export : Folding, sorting and degradation : Genetic Information Processing;Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_00385 rsmD ko:K08316 2.1.1.171 Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle NA Z1_00386 yhhL ko:K08993 Protein of unknown function (DUF1145) NA Z1_00389 zntA ko:K01534 3.6.3.3,3.6.3.5 E1-E2 ATPase NA Z1_00390 mexB ko01501,ko01503,map01501,map01503 ko:K03296,ko:K18138 AcrB/AcrD/AcrF family beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases Z1_00391 mexA ko01501,ko01503,map01501,map01503 ko:K03585 Barrel-sandwich domain of CusB or HlyD membrane-fusion beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases Z1_00392 gcd ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 ko:K00117 1.1.5.2 Dehydrogenase Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA Z1_00393 alr ko00300,ko00473,ko00550,ko01100,ko01502,map00300,map00473,map00550,map01100,map01502 ko:K01775,ko:K01929 5.1.1.1,6.3.2.10 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids Lysine biosynthesis : Amino acid metabolism : Metabolism;D-Alanine metabolism : Metabolism of other amino acids : Metabolism;Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Vancomycin resistance : Drug resistance: antimicrobial : Human Diseases Z1_00395 ulaB ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060 ko:K02822 2.7.1.194 Phosphotransferase system, galactitol-specific IIB component Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing Z1_00397 gntR ko:K06145 helix_turn _helix lactose operon repressor NA Z1_00398 yfcD ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 ko:K00949,ko:K01823 2.7.6.2,5.3.3.2 NUDIX domain Thiamine metabolism : Metabolism of cofactors and vitamins : Metabolism;Terpenoid backbone biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA Z1_00399 yfcG ko:K11209 Belongs to the GST superfamily NA Z1_00400 yfcH ko:K07071 Domain of unknown function (DUF1731) NA Z1_00401 ubiX ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 ko:K03186 2.5.1.129 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Aminobenzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Phenylpropanoid biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Degradation of aromatic compounds : Global and overview maps : Metabolism Z1_00402 purF ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 ko:K00764 2.4.2.14 glutamine phosphoribosylpyrophosphate amidotransferase Purine metabolism : Nucleotide metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA Z1_00403 cvpA ko:K03558 Colicin V production protein NA Z1_00404 dedD ko03070,ko05111,map03070,map05111 ko:K02453,ko:K03642,ko:K03749 Sporulation related domain Bacterial secretion system : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes Z1_00405 folC ko00790,ko01100,map00790,map01100 ko:K11754 6.3.2.12,6.3.2.17 Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00406 accD ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 ko:K01963 2.1.3.15,6.4.1.2 Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta Fatty acid biosynthesis : Lipid metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism Z1_00407 dedA ko:K03975 SNARE associated Golgi protein NA Z1_00409 asd ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 ko:K00133 1.2.1.11 Semialdehyde dehydrogenase, NAD binding domain Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Monobactam biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Lysine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_00410 pdxB ko00750,ko01100,map00750,map01100 ko:K03473 1.1.1.290 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate Vitamin B6 metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00413 fabB ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 ko:K00647 2.3.1.41 Beta-ketoacyl synthase, C-terminal domain Fatty acid biosynthesis : Lipid metabolism : Metabolism;Biotin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism Z1_00414 mnmC ko00130,ko01110,map00130,map01110 ko:K00773,ko:K07319,ko:K11782,ko:K15461 2.1.1.61,2.1.1.72,2.4.2.29,4.2.1.151 Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_00418 yfcM ko:K09906 Elongation factor P hydroxylase NA Z1_00419 yfcA ko:K07090,ko:K11312 Sulfite exporter TauE/SafE NA Z1_00420 aroC ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 ko:K01736 4.2.3.5 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_00421 prmB ko:K02493,ko:K07320 2.1.1.297,2.1.1.298 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue NA Z1_00422 dps ko:K04047 Ferritin-like domain NA Z1_00424 sixA ko:K08296 Phosphoglycerate mutase family NA Z1_00425 fadJ ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 ko:K01782,ko:K01825 1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8 Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities Fatty acid degradation : Lipid metabolism : Metabolism;Valine, leucine and isoleucine degradation : Amino acid metabolism : Metabolism;Geraniol degradation : Metabolism of terpenoids and polyketides : Metabolism;Lysine degradation : Amino acid metabolism : Metabolism;Benzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Tryptophan metabolism : Amino acid metabolism : Metabolism;beta-Alanine metabolism : Metabolism of other amino acids : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Limonene and pinene degradation : Metabolism of terpenoids and polyketides : Metabolism;Caprolactam degradation : Xenobiotics biodegradation and metabolism : Metabolism;Biosynthesis of unsaturated fatty acids : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism Z1_00426 fadI ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212 ko:K00632 2.3.1.16 Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed Fatty acid degradation : Lipid metabolism : Metabolism;Valine, leucine and isoleucine degradation : Amino acid metabolism : Metabolism;Geraniol degradation : Metabolism of terpenoids and polyketides : Metabolism;Benzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;alpha-Linolenic acid metabolism : Lipid metabolism : Metabolism;Ethylbenzene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Fatty acid metabolism : Global and overview maps : Metabolism Z1_00428 fadL ko:K06076 Outer membrane protein transport protein (OMPP1/FadL/TodX) NA Z1_00429 vacJ ko:K04754 MlaA lipoprotein NA Z1_00432 ko:K07090 Sulfite exporter TauE/SafE NA Z1_00433 psrA ko00920,ko01120,map00920,map01120 ko:K08352 1.8.5.5 Hydrogen sulfide production membrane anchoring protein K08352 Sulfur metabolism : Energy metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_00434 phsB ko00920,ko01120,ko02020,map00920,map01120,map02020 ko:K08353,ko:K08358 4Fe-4S binding domain Sulfur metabolism : Energy metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing Z1_00435 phsC ko00920,ko01120,ko02020,map00920,map01120,map02020 ko:K03620,ko:K08354 Prokaryotic cytochrome b561 Sulfur metabolism : Energy metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing Z1_00444 gltX ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 ko:K01885,ko:K09698 6.1.1.17,6.1.1.24 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_00449 ypeB ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 ko:K02342,ko:K09954,ko:K10857 2.7.7.7 Putative quorum-sensing-regulated virulence factor Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;DNA replication : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing Z1_00450 nupC ko:K03317,ko:K11535 Na+ dependent nucleoside transporter C-terminus NA Z1_00451 ligA ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 ko:K01972 6.5.1.2 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA DNA replication : Replication and repair : Genetic Information Processing;Base excision repair : Replication and repair : Genetic Information Processing;Nucleotide excision repair : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing Z1_00452 zipA ko:K03528 Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins NA Z1_00453 cysZ ko:K06203 High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway NA Z1_00454 cysK ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 ko:K01738 2.5.1.47 Belongs to the cysteine synthase cystathionine beta- synthase family Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_00455 ptsH ko00561,ko02060,map00561,map02060 ko:K02784,ko:K05881,ko:K08485,ko:K11189 2.7.1.121 PTS HPr component phosphorylation site Glycerolipid metabolism : Lipid metabolism : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing Z1_00456 ptsI ko00561,ko02060,map00561,map02060 ko:K05881,ko:K08483 2.7.1.121,2.7.3.9 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) Glycerolipid metabolism : Lipid metabolism : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing Z1_00457 crr ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111 ko:K02755,ko:K02756,ko:K02757,ko:K02777 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes Z1_00458 cysM ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 ko:K01738,ko:K12339 2.5.1.47 Pyridoxal-phosphate dependent enzyme Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_00459 cysA ko00920,ko02010,map00920,map02010 ko:K02017,ko:K02045,ko:K10112 3.6.3.25,3.6.3.29 Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system Sulfur metabolism : Energy metabolism : Metabolism;ABC transporters : Membrane transport : Environmental Information Processing Z1_00460 cysW ko00920,ko02010,map00920,map02010 ko:K02046,ko:K02047 sulfate ABC transporter, permease protein CysW Sulfur metabolism : Energy metabolism : Metabolism;ABC transporters : Membrane transport : Environmental Information Processing Z1_00461 cysT ko00920,ko02010,map00920,map02010 ko:K02018,ko:K02046 Sulfate ABC transporter, permease protein CysT Sulfur metabolism : Energy metabolism : Metabolism;ABC transporters : Membrane transport : Environmental Information Processing Z1_00462 ko00920,ko02010,map00920,map02010 ko:K02048 Bacterial extracellular solute-binding protein Sulfur metabolism : Energy metabolism : Metabolism;ABC transporters : Membrane transport : Environmental Information Processing Z1_00463 yfeX ko:K07223 Dyp-type peroxidase family NA Z1_00466 ko00860,ko01100,ko01110,map00860,map01100,map01110 ko:K00228 1.3.3.3 coproporphyrinogen oxidase activity Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_00468 der ko:K03977 GTPase that plays an essential role in the late steps of ribosome biogenesis NA Z1_00469 bamB ko:K17713 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane NA Z1_00471 hisS ko00970,map00970 ko:K01892 6.1.1.21 Histidyl-tRNA synthetase Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing Z1_00472 ispG ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 ko:K03526 1.17.7.1,1.17.7.3 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate Terpenoid backbone biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA Z1_00473 rodZ ko:K15539 Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis NA Z1_00474 sscB ko:K02656,ko:K20543 Type IV pilus biogenesis stability protein PilW NA Z1_00475 rlmN ko:K06941 2.1.1.192 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs NA Z1_00476 ndk ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 ko:K00940 2.7.4.6 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Drug metabolism - other enzymes : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;MAPK signaling pathway - plant : Signal transduction : Environmental Information Processing Z1_00477 pbpC ko00550,map00550 ko:K05367 2.4.1.129 penicillin-binding protein 1C Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism Z1_00478 yfhM ko:K06894 Large extracellular alpha-helical protein NA Z1_00480 pepB ko00480,ko01100,map00480,map01100 ko:K01255,ko:K07751 3.4.11.1,3.4.11.23 Probably plays an important role in intracellular peptide degradation Glutathione metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00482 fdx ko:K04755 2Fe-2S iron-sulfur cluster binding domain NA Z1_00483 hscA ko03018,ko04212,ko05152,map03018,map04212,map05152 ko:K04043,ko:K04044 Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU RNA degradation : Folding, sorting and degradation : Genetic Information Processing;Longevity regulating pathway - worm : Aging : Organismal Systems;Tuberculosis : Infectious disease: bacterial : Human Diseases Z1_00484 hscB ko:K04082,ko:K05801 Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA NA Z1_00485 iscA ko:K05997,ko:K13628 iron-sulfur cluster assembly protein NA Z1_00486 iscU ko:K04488 A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters NA Z1_00487 iscS ko00730,ko01100,ko04122,map00730,map01100,map04122 ko:K04487 2.8.1.7 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins Thiamine metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing Z1_00488 iscR ko00730,ko01100,ko04122,map00730,map01100,map04122 ko:K04487,ko:K13643 2.8.1.7 Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins Thiamine metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing Z1_00489 trmJ ko00760,ko00970,ko01100,map00760,map00970,map01100 ko:K01883,ko:K02533,ko:K08281,ko:K15396 2.1.1.200,3.5.1.19,6.1.1.16 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing;Metabolic pathways : Global and overview maps : Metabolism Z1_00490 suhB ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 ko:K01092 3.1.3.25 Inositol monophosphatase family Streptomycin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Inositol phosphate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Phosphatidylinositol signaling system : Signal transduction : Environmental Information Processing Z1_00492 ko:K01262 3.4.11.9 Metallopeptidase family M24 NA Z1_00493 hcaT ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 ko:K00286,ko:K05820,ko:K08161 1.5.1.2 MFS_1 like family Arginine and proline metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_00495 hmp ko05132,map05132 ko:K05916 1.14.12.17 Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress Salmonella infection : Infectious disease: bacterial : Human Diseases Z1_00497 glnB ko02020,map02020 ko:K04751,ko:K04752 Nitrogen regulatory protein P-II Two-component system : Signal transduction : Environmental Information Processing Z1_00498 nadE ko00760,ko01100,map00760,map01100 ko:K01916,ko:K01950 6.3.1.5,6.3.5.1 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00499 yfhA ko02020,ko02024,map02020,map02024 ko:K07715 Sigma-54 interaction domain Two-component system : Signal transduction : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_00500 yfhG ko01501,ko01503,ko02020,map01501,map01503,map02020 ko:K02487,ko:K18138 YfhG lipoprotein beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases;Two-component system : Signal transduction : Environmental Information Processing Z1_00502 purL ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 ko:K01952 6.3.5.3 Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate Purine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA Z1_00503 mltF ko:K18691 Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella NA Z1_00504 pmfA ko05133,map05133 ko:K07345,ko:K12517 Fimbrial protein Pertussis : Infectious disease: bacterial : Human Diseases Z1_00506 pmfD ko:K07346,ko:K12519 Pili assembly chaperone PapD, C-terminal domain NA Z1_00509 tadA ko00230,ko00240,ko00330,ko00361,ko00625,ko01100,ko01120,map00230,map00240,map00330,map00361,map00625,map01100,map01120 ko:K01297,ko:K01485,ko:K01487,ko:K01563,ko:K11991 3.4.17.13,3.5.4.1,3.5.4.3,3.5.4.33,3.8.1.5 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Arginine and proline metabolism : Amino acid metabolism : Metabolism;Chlorocyclohexane and chlorobenzene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Chloroalkane and chloroalkene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_00510 yfhL ko:K03522,ko:K05337 Ferredoxin NA Z1_00511 acpS ko00520,ko00531,ko00770,ko01100,ko01501,map00520,map00531,map00770,map01100,map01501 ko:K00997,ko:K01207 2.7.8.7,3.2.1.52 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Glycosaminoglycan degradation : Glycan biosynthesis and metabolism : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases Z1_00512 pdxJ ko00750,ko01100,map00750,map01100 ko:K03474 2.6.99.2 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate Vitamin B6 metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00513 recO ko00750,ko01100,ko03440,map00750,map01100,map03440 ko:K03474,ko:K03584 2.6.99.2 Involved in DNA repair and RecF pathway recombination Vitamin B6 metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Homologous recombination : Replication and repair : Genetic Information Processing Z1_00514 era ko:K03595 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism NA Z1_00515 rnc ko03008,ko05205,map03008,map05205 ko:K03685 3.1.26.3 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism Ribosome biogenesis in eukaryotes : Translation : Genetic Information Processing;Proteoglycans in cancer : Cancer: overview : Human Diseases Z1_00516 lepB ko02024,ko03060,map02024,map03060 ko:K03100 3.4.21.89 Belongs to the peptidase S26 family Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Protein export : Folding, sorting and degradation : Genetic Information Processing Z1_00517 lepA ko05134,map05134 ko:K03596 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner Legionellosis : Infectious disease: bacterial : Human Diseases Z1_00518 rseC ko:K03803 Positive regulator of sigma(E), RseC/MucC NA Z1_00519 rseB ko:K03598 MucB/RseB C-terminal domain NA Z1_00520 rseA ko:K03597 An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E NA Z1_00521 rpoE ko:K03088 Belongs to the sigma-70 factor family. ECF subfamily NA Z1_00522 yfiC ko:K00571,ko:K15460 2.1.1.223,2.1.1.72 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) NA Z1_00523 srmB ko03018,map03018 ko:K05590,ko:K11927 3.6.4.13 Belongs to the DEAD box helicase family RNA degradation : Folding, sorting and degradation : Genetic Information Processing Z1_00524 grcA ko00623,ko00625,ko01100,ko01120,ko01220,map00623,map00625,map01100,map01120,map01220 ko:K06866,ko:K15763,ko:K22361 1.14.13.236 Acts as a radical domain for damaged PFL and possibly other radical proteins Toluene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Chloroalkane and chloroalkene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Degradation of aromatic compounds : Global and overview maps : Metabolism Z1_00525 ung ko03410,ko05340,map03410,map05340 ko:K03648 3.2.2.27 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine Base excision repair : Replication and repair : Genetic Information Processing;Primary immunodeficiency : Immune disease : Human Diseases Z1_00526 grpE ko:K03687 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ NA Z1_00527 nadK ko00760,ko01100,map00760,map01100 ko:K00858 2.7.1.23 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00528 recN ko:K03631 repair protein NA Z1_00529 bamE ko:K06186 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane NA Z1_00530 rnfH ko04122,map04122 ko:K03154,ko:K09801 RnfH family Ubiquitin Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing Z1_00531 ratA ko:K18588 Polyketide cyclase / dehydrase and lipid transport NA Z1_00532 smpB ko:K03664 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene NA Z1_00534 ko:K07028 AAA domain NA Z1_00535 ko00230,map00230 ko:K01515 3.6.1.13 Belongs to the Nudix hydrolase family Purine metabolism : Nucleotide metabolism : Metabolism Z1_00537 hsdM ko:K03427 2.1.1.72 COG0286 Type I restriction-modification system methyltransferase subunit NA Z1_00538 hsdS ko:K01154 3.1.21.3 Type I restriction modification DNA specificity domain NA Z1_00541 hsdR ko:K01153 3.1.21.3 Subunit R is required for both nuclease and ATPase activities, but not for modification NA Z1_00542 ko:K07043 Protein of unknown function DUF45 NA Z1_00544 ko:K07076 Nucleotidyltransferase domain NA Z1_00546 ko:K00375 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs NA Z1_00550 CP_0471 ko:K07126 beta-lactamase activity NA Z1_00555 ko:K07088 Membrane transport protein NA Z1_00556 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 ko:K01834 5.4.2.11 alpha-ribazole phosphatase activity Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism;Glucagon signaling pathway : Endocrine system : Organismal Systems;Central carbon metabolism in cancer : Cancer: overview : Human Diseases Z1_00558 ydhP ko:K19577 Major facilitator Superfamily NA Z1_00560 lutA ko:K18928 Cysteine-rich domain NA Z1_00562 lutC ko:K00782 LUD domain NA Z1_00564 ko:K09922 Putative member of DMT superfamily (DUF486) NA Z1_00566 ykgJ ko:K06940 Putative zinc- or iron-chelating domain NA Z1_00567 yijF ko:K09974 Domain of unknown function (DUF1287) NA Z1_00568 ko:K02532 Major facilitator superfamily NA Z1_00569 ko:K07017 Putative esterase NA Z1_00571 ko:K14388 Sodium:solute symporter family NA Z1_00572 galR ko:K02529 Periplasmic binding protein-like domain NA Z1_00573 galM ko00010,ko00052,ko00520,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map00520,map01100,map01110,map01120,map01130 ko:K00849,ko:K01785 2.7.1.6,5.1.3.3 Aldose 1-epimerase Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA Z1_00575 ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917 ko:K00965 2.7.7.12 Galactose-1-phosphate uridyl transferase, C-terminal domain Galactose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Prolactin signaling pathway : Endocrine system : Organismal Systems Z1_00576 galE ko00052,ko00520,ko01100,map00052,map00520,map01100 ko:K01784 5.1.3.2 Male sterility protein Galactose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00577 ghrB ko00030,ko00260,ko00480,ko00620,ko00630,ko01100,ko01110,ko01120,map00030,map00260,map00480,map00620,map00630,map01100,map01110,map01120 ko:K00015,ko:K00032,ko:K00090 1.1.1.215,1.1.1.26,1.1.1.43,1.1.1.79,1.1.1.81 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Glutathione metabolism : Metabolism of other amino acids : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_00580 eco ko:K08276 Ecotin NA Z1_00581 ydcH ko:K09794 Protein of unknown function (DUF465) NA Z1_00583 ko:K12149 DinI-like family NA Z1_00585 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 ko:K03790,ko:K13832 1.1.1.25,2.3.1.128,4.2.1.10 Acetyltransferase (GNAT) domain Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_00587 exsA ko02025,map02025 ko:K20968 COG2207 AraC-type DNA-binding domain-containing proteins Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes Z1_00589 ko:K01802 5.2.1.8 peptidylprolyl isomerase NA Z1_00591 azr ko:K19784 NADPH-dependent FMN reductase NA Z1_00594 fimB ko:K07346 Pili assembly chaperone PapD, C-terminal domain NA Z1_00596 stbC ko05133,map05133 ko:K07347 PapC C-terminal domain Pertussis : Infectious disease: bacterial : Human Diseases Z1_00597 stbB ko:K07346,ko:K15540 Pili assembly chaperone PapD, C-terminal domain NA Z1_00598 ko05133,map05133 ko:K07345 Type-1 fimbrial protein, A Pertussis : Infectious disease: bacterial : Human Diseases Z1_00599 ko05111,map05111 ko:K10921 Transcriptional regulatory protein, C-terminal domain protein Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes Z1_00601 ko05111,map05111 ko:K10921 Transcriptional regulatory protein, C terminal Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes Z1_00603 ko02020,map02020 ko:K07804,ko:K11934 Enterobacterial Ail/Lom protein Two-component system : Signal transduction : Environmental Information Processing Z1_00606 lysS ko00970,map00970 ko:K04567 6.1.1.6 Belongs to the class-II aminoacyl-tRNA synthetase family Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing Z1_00607 prfB ko:K02836 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA NA Z1_00608 recJ ko03410,ko03430,ko03440,map03410,map03430,map03440 ko:K07462 DHH family Base excision repair : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing Z1_00609 dsbC ko:K03981 5.3.4.1 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process NA Z1_00610 xerD ko:K04763 Phage integrase, N-terminal SAM-like domain NA Z1_00611 fldB ko:K03839,ko:K03840 Flavodoxin NA Z1_00612 ygfX ko:K19168 Membrane-bound toxin component of toxin-antitoxin system NA Z1_00614 sdhE ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 ko:K00240,ko:K09159 1.3.5.1,1.3.5.4 Flavinator of succinate dehydrogenase Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Oxidative phosphorylation : Energy metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism Z1_00615 ygfZ ko:K06980,ko:K22073 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication NA Z1_00616 maf ko:K07023 HD domain NA Z1_00617 gcvP ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 ko:K00281,ko:K00282 1.4.4.2 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism Z1_00618 gcvH ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 ko:K02437 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism Z1_00619 gcvT ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 ko:K00605 2.1.2.10 The glycine cleavage system catalyzes the degradation of glycine Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism Z1_00620 visC ko00130,ko01100,ko01110,map00130,map01100,map01110 ko:K03184,ko:K03185,ko:K18800 Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 family Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_00621 ubiH ko00130,ko01100,ko01110,map00130,map01100,map01110 ko:K03184,ko:K03185,ko:K18800 hydroxylase Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_00622 pepP ko:K01262 3.4.11.9 Xaa-Pro aminopeptidase (X-Pro aminopeptidase) (aminopeptidase P II) (APP-II) (aminoacylproline aminopeptidase) K01262 NA Z1_00623 ygfB ko:K09895 Uncharacterised protein family (UPF0149) NA Z1_00624 zapA ko:K09888 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division NA Z1_00625 fthC ko00670,ko01100,map00670,map01100 ko:K01934 6.3.3.2 5-formyltetrahydrofolate cyclo-ligase family One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00626 apxIB_2 ko02010,ko02020,ko03070,ko05133,map02010,map02020,map03070,map05133 ko:K11004,ko:K12530,ko:K12531 ABC transporter transmembrane region ABC transporters : Membrane transport : Environmental Information Processing;Two-component system : Signal transduction : Environmental Information Processing;Bacterial secretion system : Membrane transport : Environmental Information Processing;Pertussis : Infectious disease: bacterial : Human Diseases Z1_00627 hlyD ko02020,ko03070,ko05133,map02020,map03070,map05133 ko:K02022,ko:K11003,ko:K12532 HlyD membrane-fusion protein of T1SS Two-component system : Signal transduction : Environmental Information Processing;Bacterial secretion system : Membrane transport : Environmental Information Processing;Pertussis : Infectious disease: bacterial : Human Diseases Z1_00628 hlyB ko02010,ko02020,ko03070,ko05133,map02010,map02020,map03070,map05133 ko:K11004,ko:K12530,ko:K12531 Psort location CytoplasmicMembrane, score ABC transporters : Membrane transport : Environmental Information Processing;Two-component system : Signal transduction : Environmental Information Processing;Bacterial secretion system : Membrane transport : Environmental Information Processing;Pertussis : Infectious disease: bacterial : Human Diseases Z1_00630 rpiA ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230 ko:K01807 5.3.1.6 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_00634 yggE ko:K09807 Protein of unknown function (DUF541) NA Z1_00635 argO ko:K06895 Involved in the export of arginine. Important to control the intracellular level of arginine and the correct balance between arginine and lysine NA Z1_00636 mscS ko:K03442 Conserved TM helix NA Z1_00637 yacL ko:K09910 Uncharacterised protein family (UPF0231) NA Z1_00638 acnB ko00020,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 ko:K01682 4.2.1.3,4.2.1.99 aconitate hydratase 2 (citrate hydro-lyase 2) (aconitase 2) K01682 Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_00642 rtxA ko02024,ko05110,map02024,map05110 ko:K05802,ko:K06889,ko:K07052,ko:K10953,ko:K20276 Peptidase C80 family Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Vibrio cholerae infection : Infectious disease: bacterial : Human Diseases Z1_00643 rtxA ko02024,ko05110,map02024,map05110 ko:K05802,ko:K06889,ko:K07052,ko:K10953,ko:K20276 Peptidase C80 family Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Vibrio cholerae infection : Infectious disease: bacterial : Human Diseases Z1_00644 lpdA ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 ko:K00382 1.8.1.4 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Valine, leucine and isoleucine degradation : Amino acid metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism Z1_00645 aceF ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 ko:K00627 2.3.1.12 acetyltransferase component of pyruvate dehydrogenase complex Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism Z1_00646 aceE ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 ko:K00163 1.2.4.1 pyruvate dehydrogenase E1 component Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism Z1_00647 pdhR ko:K05799 FCD NA Z1_00648 ampD ko:K03806,ko:K11066 3.5.1.28 Ami_2 NA Z1_00649 ppdD ko02020,map02020 ko:K02650,ko:K02682 Prokaryotic N-terminal methylation motif Two-component system : Signal transduction : Environmental Information Processing Z1_00650 hofB ko03070,ko05111,map03070,map05111 ko:K02454,ko:K02504,ko:K02652 Type II/IV secretion system protein Bacterial secretion system : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes Z1_00651 hofC ko:K02505,ko:K02653 Type II secretion system (T2SS), protein F NA Z1_00652 coaE ko00770,ko01100,map00770,map01100 ko:K00859 2.7.1.24 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00653 zapD ko:K18778 Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity NA Z1_00654 yacG ko00770,ko01100,map00770,map01100 ko:K00859,ko:K09862 2.7.1.24 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00655 mutT ko:K03574,ko:K08320 3.6.1.55,3.6.1.65 NUDIX domain NA Z1_00656 shlB ko03070,map03070 ko:K11017 POTRA domain Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_00657 shlA ko03070,ko05133,map03070,map05133 ko:K11016,ko:K15125 Haemagluttinin repeat Bacterial secretion system : Membrane transport : Environmental Information Processing;Pertussis : Infectious disease: bacterial : Human Diseases Z1_00658 secA ko02024,ko03060,ko03070,map02024,map03060,map03070 ko:K03070 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Protein export : Folding, sorting and degradation : Genetic Information Processing;Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_00659 secM ko03060,ko03070,map03060,map03070 ko:K13301 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation Protein export : Folding, sorting and degradation : Genetic Information Processing;Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_00661 lpxC ko00061,ko00540,ko01100,ko01212,map00061,map00540,map01100,map01212 ko:K02535,ko:K16363 3.5.1.108,4.2.1.59 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis Fatty acid biosynthesis : Lipid metabolism : Metabolism;Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism Z1_00662 ftsZ ko04112,map04112 ko:K03531 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity Cell cycle - Caulobacter : Cell growth and death : Cellular Processes Z1_00663 ftsA ko04112,map04112 ko:K03590 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring Cell cycle - Caulobacter : Cell growth and death : Cellular Processes Z1_00664 ftsQ ko00473,ko00550,ko01100,ko01502,ko04112,map00473,map00550,map01100,map01502,map04112 ko:K01921,ko:K03589 6.3.2.4 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly D-Alanine metabolism : Metabolism of other amino acids : Metabolism;Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Vancomycin resistance : Drug resistance: antimicrobial : Human Diseases;Cell cycle - Caulobacter : Cell growth and death : Cellular Processes Z1_00666 murC ko00471,ko00550,ko01100,map00471,map00550,map01100 ko:K01924,ko:K02558 6.3.2.45,6.3.2.8 Belongs to the MurCDEF family D-Glutamine and D-glutamate metabolism : Metabolism of other amino acids : Metabolism;Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00668 ftsW ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 ko:K02563,ko:K03588 2.4.1.227 Belongs to the SEDS family Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Vancomycin resistance : Drug resistance: antimicrobial : Human Diseases;Cell cycle - Caulobacter : Cell growth and death : Cellular Processes Z1_00669 murD ko00471,ko00550,ko01100,map00471,map00550,map01100 ko:K01925 6.3.2.9 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) D-Glutamine and D-glutamate metabolism : Metabolism of other amino acids : Metabolism;Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00670 mraY ko00550,ko01100,ko01502,map00550,map01100,map01502 ko:K01000 2.7.8.13 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Vancomycin resistance : Drug resistance: antimicrobial : Human Diseases Z1_00671 murF ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 ko:K01929 6.3.2.10 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein Lysine biosynthesis : Amino acid metabolism : Metabolism;Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Vancomycin resistance : Drug resistance: antimicrobial : Human Diseases Z1_00672 murE ko00300,ko00550,ko01501,map00300,map00550,map01501 ko:K01928,ko:K03587,ko:K15792 3.4.16.4,6.3.2.10,6.3.2.13 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan Lysine biosynthesis : Amino acid metabolism : Metabolism;Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases Z1_00673 ftsI ko00550,ko01100,ko01501,map00550,map01100,map01501 ko:K03587,ko:K08384,ko:K08724,ko:K12552,ko:K12556 3.4.16.4 Catalyzes cross-linking of the peptidoglycan cell wall at the division septum Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases Z1_00674 ftsL ko:K03586 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic NA Z1_00675 rsmH ko:K03438 2.1.1.199 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA NA Z1_00676 mraZ ko:K03925 Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster. Acts by binding directly to DNA. May also regulate the expression of genes outside the dcw cluster NA Z1_00677 fruR ko00052,ko00500,ko01100,map00052,map00500,map01100 ko:K01193,ko:K02529,ko:K03435 3.2.1.26 helix_turn _helix lactose operon repressor Galactose metabolism : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00678 fadD ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 ko:K01897 6.2.1.3 AMP-binding enzyme Fatty acid biosynthesis : Lipid metabolism : Metabolism;Fatty acid degradation : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;PPAR signaling pathway : Endocrine system : Organismal Systems;Peroxisome : Transport and catabolism : Cellular Processes;Ferroptosis : Cell growth and death : Cellular Processes;Thermogenesis : Environmental adaptation : Organismal Systems;Adipocytokine signaling pathway : Endocrine system : Organismal Systems Z1_00679 leuO ko:K05798 transcriptional regulator NA Z1_00680 leuA ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 ko:K01649 2.3.3.13 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) Valine, leucine and isoleucine biosynthesis : Amino acid metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_00681 leuB ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 ko:K00052 1.1.1.85 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate Valine, leucine and isoleucine biosynthesis : Amino acid metabolism : Metabolism;C5-Branched dibasic acid metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_00683 leuD ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 ko:K01704 4.2.1.33,4.2.1.35 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate Valine, leucine and isoleucine biosynthesis : Amino acid metabolism : Metabolism;C5-Branched dibasic acid metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_00685 mutH ko03430,map03430 ko:K03573 Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair Mismatch repair : Replication and repair : Genetic Information Processing Z1_00688 speB ko00330,ko01100,ko02010,map00330,map01100,map02010 ko:K01480,ko:K12541 3.5.3.11 Catalyzes the formation of putrescine from agmatine Arginine and proline metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;ABC transporters : Membrane transport : Environmental Information Processing Z1_00689 speA ko00330,ko01100,map00330,map01100 ko:K01585 4.1.1.19 biosynthetic arginine decarboxylase Arginine and proline metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00690 metK ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 ko:K00789 2.5.1.6 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_00691 kbaA ko00540,ko01503,map00540,map01503 ko:K03760,ko:K06349,ko:K12975,ko:K19353 2.7.8.42,2.7.8.43 Cellulose biosynthesis protein BcsG Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases Z1_00693 parA ko:K03496 Cellulose biosynthesis protein BcsQ NA Z1_00694 bcsA ko00500,ko01100,ko02026,map00500,map01100,map02026 ko:K00694 2.4.1.12 Cellulose synthase Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes Z1_00695 bcsB ko:K20541 Bacterial cellulose synthase subunit NA Z1_00696 bcsC ko02020,ko02025,map02020,map02025 ko:K07272,ko:K13486,ko:K20543,ko:K21007 Cellulose synthase Two-component system : Signal transduction : Environmental Information Processing;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes Z1_00697 ko:K07112 Transporter Component NA Z1_00698 ko:K07112 transporter component NA Z1_00700 sprT ko:K02742 SprT-like zinc ribbon domain NA Z1_00703 mgtE ko00190,map00190 ko:K04767,ko:K06213,ko:K15986 3.6.1.1 Acts as a magnesium transporter Oxidative phosphorylation : Energy metabolism : Metabolism Z1_00705 hcr ko:K11933 Oxidoreductase FAD-binding domain NA Z1_00706 hcp ko00910,map00910 ko:K05601 1.7.99.1 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O Nitrogen metabolism : Energy metabolism : Metabolism Z1_00707 aldA ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 ko:K00128 1.2.1.3 Aldehyde dehydrogenase family Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Fatty acid degradation : Lipid metabolism : Metabolism;Valine, leucine and isoleucine degradation : Amino acid metabolism : Metabolism;Lysine degradation : Amino acid metabolism : Metabolism;Arginine and proline metabolism : Amino acid metabolism : Metabolism;Histidine metabolism : Amino acid metabolism : Metabolism;Tryptophan metabolism : Amino acid metabolism : Metabolism;beta-Alanine metabolism : Metabolism of other amino acids : Metabolism;Glycerolipid metabolism : Lipid metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Chloroalkane and chloroalkene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Limonene and pinene degradation : Metabolism of terpenoids and polyketides : Metabolism;Insect hormone biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA Z1_00708 alsT ko:K03310 Sodium:alanine symporter family NA Z1_00709 clcA ko:K03281 Voltage gated chloride channel NA Z1_00710 tehB ko:K03647,ko:K16868 2.1.1.265 Tellurite resistance protein TehB NA Z1_00711 kch ko:K10716 Potassium channel NA Z1_00714 yceJ ko:K12262 Prokaryotic cytochrome b561 NA Z1_00718 iucB ko00261,ko00300,ko00310,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map00310,map01100,map01110,map01120,map01130,map01230 ko:K00215,ko:K00663,ko:K03789,ko:K03790,ko:K03894,ko:K03896,ko:K06140,ko:K18816,ko:K21992 1.17.1.8,2.3.1.102,2.3.1.128,2.3.1.82,6.3.2.38 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins Monobactam biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Lysine biosynthesis : Amino acid metabolism : Metabolism;Lysine degradation : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_00720 Z012_03425 ko00531,ko01100,ko04142,map00531,map01100,map04142 ko:K01137,ko:K01138 3.1.6.14 Sulfatase Glycosaminoglycan degradation : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Lysosome : Transport and catabolism : Cellular Processes Z1_00723 Z012_00015 ko:K08961 4.2.2.20,4.2.2.21 Chondroitin sulfate ABC lyase NA Z1_00724 ChABCII ko:K08961 4.2.2.20,4.2.2.21 Broad-specificity glycosaminoglycan lyase NA Z1_00727 kduI ko00040,map00040 ko:K01815 5.3.1.17 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism Z1_00728 Z012_03490 ko00052,map00052 ko:K02079 3.5.1.25 Belongs to the metallo-dependent hydrolases superfamily. NagA family Galactose metabolism : Carbohydrate metabolism : Metabolism Z1_00729 agaF ko00052,ko02060,map00052,map02060 ko:K02744 PTS system fructose IIA component Galactose metabolism : Carbohydrate metabolism : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing Z1_00730 agaD ko00051,ko00052,ko00520,ko01100,ko02060,map00051,map00052,map00520,map01100,map02060 ko:K02747,ko:K02796 PTS system mannose/fructose/sorbose family IID component Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing Z1_00731 agaC ko00052,ko02060,map00052,map02060 ko:K02746 PTS system sorbose-specific iic component Galactose metabolism : Carbohydrate metabolism : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing Z1_00732 agaV ko00051,ko00052,ko00520,ko01100,ko02060,map00051,map00052,map00520,map01100,map02060 ko:K02745,ko:K02794 2.7.1.191 PTS system sorbose subfamily IIB component Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing Z1_00733 agaS ko:K02082 isomerase NA Z1_00735 agaR ko:K02081 DeoR C terminal sensor domain NA Z1_00736 Z012_03470 ko:K06871 radical SAM domain protein NA Z1_00737 ydeN ko:K01138 Sulfatase NA Z1_00739 gatY ko00052,ko01100,map00052,map01100 ko:K08302 4.1.2.40 Class II aldolase, tagatose bisphosphate family Galactose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00740 kdgK ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 ko:K00874 2.7.1.45 pfkB family carbohydrate kinase Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism Z1_00741 eda ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200 ko:K00874,ko:K01625 2.7.1.45,4.1.2.14,4.1.3.42 KDPG and KHG aldolase Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism Z1_00742 thiJ ko:K03152,ko:K05520,ko:K12132 2.7.11.1,3.5.1.124 DJ-1/PfpI family NA Z1_00743 ko00260,ko01100,map00260,map01100 ko:K00303 1.5.3.1 FAD dependent oxidoreductase Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00745 yddE ko00405,ko01130,ko02024,map00405,map01130,map02024 ko:K06998 5.3.3.17 Phenazine biosynthesis-like protein Phenazine biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;NA : NA : NA;Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_00746 arsB ko:K03893 Involved in arsenical resistance. Thought to form the channel of an arsenite pump NA Z1_00747 arsR ko:K03892,ko:K21903 helix_turn_helix, Arsenical Resistance Operon Repressor NA Z1_00750 yfdH ko:K20534 Catalyzes the transfer of 4-deoxy-4-formamido-L- arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides NA Z1_00753 imd ko:K20847 3.2.1.94 cellulase activity NA Z1_00757 ko:K05802 tape measure protein NA Z1_00772 ko:K06909 Phage terminase, large subunit, PBSX family NA Z1_00776 tssI ko03070,map03070 ko:K11904 vgr_GE Rhs element Vgr family protein Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_00783 znuB ko02010,map02010 ko:K02075,ko:K09816 ABC 3 transport family ABC transporters : Membrane transport : Environmental Information Processing Z1_00784 znuC ko02010,map02010 ko:K02074,ko:K09817,ko:K11607 Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system ABC transporters : Membrane transport : Environmental Information Processing Z1_00785 znuA ko02010,map02010 ko:K09815 Zinc-uptake complex component A periplasmic ABC transporters : Membrane transport : Environmental Information Processing Z1_00786 yebA ko:K19304,ko:K21472 Opacity-associated protein A LysM-like domain NA Z1_00787 lpxM ko00540,ko01100,map00540,map01100 ko:K02517,ko:K02560,ko:K12974 2.3.1.241,2.3.1.242,2.3.1.243 Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)-lipid A Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00788 pyk ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 ko:K00873 2.7.1.40 Pyruvate kinase Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Purine metabolism : Nucleotide metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism;Glucagon signaling pathway : Endocrine system : Organismal Systems;Type II diabetes mellitus : Endocrine and metabolic disease : Human Diseases;Human papillomavirus infection : Infectious disease: viral : Human Diseases;Viral carcinogenesis : Cancer: overview : Human Diseases;Central carbon metabolism in cancer : Cancer: overview : Human Diseases Z1_00789 hexR ko:K15835,ko:K19337 Helix-turn-helix domain, rpiR family NA Z1_00790 zwf ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 ko:K00036 1.1.1.363,1.1.1.49 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Glutathione metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Central carbon metabolism in cancer : Cancer: overview : Human Diseases Z1_00791 mdtJ ko:K11743 Catalyzes the excretion of spermidine NA Z1_00792 mdtI ko:K03297,ko:K11742 Catalyzes the excretion of spermidine NA Z1_00795 dinG ko:K03722 3.6.4.12 helicase NA Z1_00796 yeaZ ko:K01409,ko:K14742 2.3.1.234 Glycoprotease family NA Z1_00797 slp ko:K07285 Outer membrane lipoprotein Slp family NA Z1_00798 fadD ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 ko:K01897 6.2.1.3 AMP-binding enzyme Fatty acid biosynthesis : Lipid metabolism : Metabolism;Fatty acid degradation : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;PPAR signaling pathway : Endocrine system : Organismal Systems;Peroxisome : Transport and catabolism : Cellular Processes;Ferroptosis : Cell growth and death : Cellular Processes;Thermogenesis : Environmental adaptation : Organismal Systems;Adipocytokine signaling pathway : Endocrine system : Organismal Systems Z1_00799 rnd ko:K03684 3.1.13.5 Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides NA Z1_00800 minE ko:K03608 Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell NA Z1_00801 minD ko:K03609 Anion-transporting ATPase NA Z1_00802 minC ko:K03610,ko:K09749 Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization NA Z1_00803 ycgL ko:K09902 YcgL domain NA Z1_00804 mltB ko:K08305 Transglycosylase SLT domain NA Z1_00806 ycgN ko:K09160 Putative zinc- or iron-chelating domain NA Z1_00807 ybbM ko:K02069 Uncharacterised protein family (UPF0014) NA Z1_00808 ybbL ko02010,map02010 ko:K02065,ko:K02068 Rad17 cell cycle checkpoint protein ABC transporters : Membrane transport : Environmental Information Processing Z1_00809 ko:K06889 BAAT / Acyl-CoA thioester hydrolase C terminal NA Z1_00810 ko:K05804,ko:K13653,ko:K19056 helix_turn_helix, arabinose operon control protein NA Z1_00811 tetC ko:K19047 Bacterial regulatory proteins, tetR family NA Z1_00812 tar ko02020,ko02030,map02020,map02030 ko:K03406,ko:K05874,ko:K05875,ko:K05877 chemotaxis, protein Two-component system : Signal transduction : Environmental Information Processing;Bacterial chemotaxis : Cell motility : Cellular Processes Z1_00813 ldhA ko00620,ko01120,map00620,map01120 ko:K03778 1.1.1.28 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_00814 ydbH ko:K07114 Dicarboxylate transport NA Z1_00816 ydbL ko:K09978 Protein of unknown function (DUF1318) NA Z1_00817 ko:K07349 Fimbrial protein NA Z1_00818 ko05133,map05133 ko:K07347 Outer membrane usher protein Pertussis : Infectious disease: bacterial : Human Diseases Z1_00819 ko05133,map05133 ko:K07347 Outer membrane usher protein Pertussis : Infectious disease: bacterial : Human Diseases Z1_00820 ko:K07346,ko:K12519 Pili and flagellar-assembly chaperone, PapD N-terminal domain NA Z1_00822 azoR ko:K01118 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity NA Z1_00823 hrpA ko:K03578 3.6.4.13 ATP-dependent helicase NA Z1_00826 ko05133,map05133 ko:K07347 Usher protein Pertussis : Infectious disease: bacterial : Human Diseases Z1_00827 ko:K07346,ko:K12519 pilus organization NA Z1_00829 ydgI ko:K03758 aromatic amino acid transport protein AroP K03293 NA Z1_00831 pntA ko00760,ko01100,map00760,map01100 ko:K00324 1.6.1.2 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00832 pntB ko00760,ko01100,map00760,map01100 ko:K00325 1.6.1.2 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00834 fnr ko:K01420 Cyclic nucleotide-monophosphate binding domain NA Z1_00836 dmsB ko00920,map00920 ko:K07307 4Fe-4S binding domain Sulfur metabolism : Energy metabolism : Metabolism Z1_00837 ko00920,map00920 ko:K07308 DMSO reductase anchor subunit (DmsC) Sulfur metabolism : Energy metabolism : Metabolism Z1_00838 nifJ ko00010,ko00020,ko00620,ko00650,ko00720,ko00760,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map00760,map01100,map01120,map01130,map01200 ko:K00176,ko:K00528,ko:K03737,ko:K20449 1.18.1.2,1.19.1.1,1.2.7.1,1.2.7.3,1.3.7.1 4Fe-4S dicluster domain Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism Z1_00839 ppsC ko:K00344 1.6.5.5 Zinc-binding dehydrogenase NA Z1_00844 ahpC ko04214,map04214 ko:K03386 1.11.1.15 C-terminal domain of 1-Cys peroxiredoxin Apoptosis - fly : Cell growth and death : Cellular Processes Z1_00845 ahpF ko:K03387 alkyl hydroperoxide reductase F52A protein subunit F K03387 NA Z1_00848 ko:K06889 Prolyl oligopeptidase family NA Z1_00849 ko:K06889 Prolyl oligopeptidase family NA Z1_00851 ko:K03830 Acetyltransferase (GNAT) domain NA Z1_00852 ko:K07088 Sodium Bile acid symporter family NA Z1_00854 amn ko00230,map00230 ko:K01241 3.2.2.4 Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations Purine metabolism : Nucleotide metabolism : Metabolism Z1_00856 iaaA ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 ko:K01424,ko:K13051 3.4.19.5,3.5.1.1 Asparaginase Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Cyanoamino acid metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_00857 yhiI ko:K01993 Secretion protein NA Z1_00858 rbbA ko:K01990,ko:K13926 AAA domain, putative AbiEii toxin, Type IV TA system NA Z1_00859 yhhJ ko:K01992 ABC-2 family transporter protein NA Z1_00862 kdpC ko02020,map02020 ko:K01548 3.6.3.12 K+-transporting ATPase, c chain Two-component system : Signal transduction : Environmental Information Processing Z1_00863 kdpB ko02020,map02020 ko:K01547 3.6.3.12 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system Two-component system : Signal transduction : Environmental Information Processing Z1_00865 ko:K06867 Ankyrin repeats (many copies) NA Z1_00866 guaD ko:K11991 3.5.4.33 deaminase NA Z1_00868 dmsC ko00920,map00920 ko:K07308 DMSO reductase anchor subunit (DmsC) Sulfur metabolism : Energy metabolism : Metabolism Z1_00869 dmsB ko00920,map00920 ko:K07307,ko:K07311 Dimethylsulfoxide reductase, chain B Sulfur metabolism : Energy metabolism : Metabolism Z1_00870 dmsA ko00920,map00920 ko:K07306 1.8.5.3 Molybdopterin oxidoreductase Fe4S4 domain Sulfur metabolism : Energy metabolism : Metabolism Z1_00871 rbsK ko00030,ko00051,ko00500,ko00520,ko01100,map00030,map00051,map00500,map00520,map01100 ko:K00847,ko:K00852,ko:K02444 2.7.1.15,2.7.1.4 Phosphomethylpyrimidine kinase Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00874 MA20_15815 ko02020,map02020 ko:K07793 Tripartite tricarboxylate transporter TctA family Two-component system : Signal transduction : Environmental Information Processing Z1_00875 dhaK ko00051,ko00561,ko00680,ko01100,ko01120,ko01200,ko04622,map00051,map00561,map00680,map01100,map01120,map01200,map04622 ko:K00863,ko:K05878 2.7.1.121,2.7.1.28,2.7.1.29,4.6.1.15 Dak1 domain Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Glycerolipid metabolism : Lipid metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism;RIG-I-like receptor signaling pathway : Immune system : Organismal Systems Z1_00876 yloV ko00561,ko01100,map00561,map01100 ko:K05879,ko:K07030 2.7.1.121 Dak2 Glycerolipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00877 ko00261,ko00300,ko00520,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map00520,map01100,map01110,map01120,map01130,map01230 ko:K01639,ko:K01714 4.1.3.3,4.3.3.7 Dihydrodipicolinate synthetase family Monobactam biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Lysine biosynthesis : Amino acid metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_00878 srr ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 ko:K01754 4.3.1.19 Pyridoxal-phosphate dependent enzyme Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Valine, leucine and isoleucine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_00879 yabJ ko:K09022 3.5.99.10 Endoribonuclease L-PSP NA Z1_00881 leuE ko:K11250 LysE type translocator NA Z1_00882 MA20_21430 ko:K07006 5'-phosphate oxidase NA Z1_00883 alkA ko03410,map03410 ko:K00567,ko:K01247 2.1.1.63,3.2.2.21 Helix-hairpin-helix DNA-binding motif class 1 Base excision repair : Replication and repair : Genetic Information Processing Z1_00884 ada ko03410,map03410 ko:K00567,ko:K03490,ko:K10778,ko:K13529,ko:K13530,ko:K15051 2.1.1.63,3.2.2.21 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain Base excision repair : Replication and repair : Genetic Information Processing Z1_00885 yqfB ko:K09900 ASCH NA Z1_00886 tlrC ko02010,map02010 ko:K06158,ko:K18230 ATPases associated with a variety of cellular activities ABC transporters : Membrane transport : Environmental Information Processing Z1_00887 ddl ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 ko:K01921 6.3.2.4 Cell wall formation D-Alanine metabolism : Metabolism of other amino acids : Metabolism;Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Vancomycin resistance : Drug resistance: antimicrobial : Human Diseases Z1_00891 metQ ko02010,map02010 ko:K02072,ko:K02073 NLPA lipoprotein ABC transporters : Membrane transport : Environmental Information Processing Z1_00892 mdeA ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 ko:K01739,ko:K01760,ko:K01761 2.5.1.48,4.4.1.11,4.4.1.8 Cys/Met metabolism PLP-dependent enzyme Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_00896 accA ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 ko:K01962,ko:K01963 2.1.3.15,6.4.1.2 acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha Fatty acid biosynthesis : Lipid metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism Z1_00897 accA ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 ko:K01962,ko:K01963 2.1.3.15,6.4.1.2 acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha Fatty acid biosynthesis : Lipid metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism Z1_00902 ybiT ko:K06158 ABC transporter ATP-binding protein YbiT K01957 NA Z1_00903 yaiI ko:K09768 Uncharacterized BCR, YaiI/YqxD family COG1671 NA Z1_00906 mdtL ko:K07552,ko:K08163,ko:K18552 Major facilitator Superfamily NA Z1_00908 selU ko:K06917 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA NA Z1_00910 mdtN_2 ko:K03543,ko:K15549 Barrel-sandwich domain of CusB or HlyD membrane-fusion NA Z1_00911 mdtO ko:K15547 Resistance protein NA Z1_00914 yegD ko:K04046,ko:K18640 Hsp70 protein NA Z1_00915 ltaE ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 ko:K01620 4.1.2.48 Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_00919 xylA ko00040,ko00051,ko01100,map00040,map00051,map01100 ko:K01805 5.3.1.5 Belongs to the xylose isomerase family Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00920 nhaC ko:K03315 Na+/H+ antiporter family NA Z1_00921 Z012_05710 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 ko:K14155 4.4.1.8 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_00922 xylR ko00040,ko01100,map00040,map01100 ko:K01812,ko:K02529,ko:K16210 5.3.1.12 transcriptional regulator Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00923 IV02_09080 ko:K06867 DNA-binding protein VF530 NA Z1_00924 ko:K06889 COG1073 Hydrolases of the alpha beta superfamily NA Z1_00925 ko:K06887 Type VI secretion system effector, Hcp1 family NA Z1_00927 ko:K03824,ko:K04766 Acetyltransferase (GNAT) domain NA Z1_00929 osmB ko:K04062 Glycine zipper 2TM domain NA Z1_00930 ydfG ko00240,ko00260,ko01100,map00240,map00260,map01100 ko:K16066 1.1.1.381 Enoyl-(Acyl carrier protein) reductase Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00933 bioD ko00780,ko01100,map00780,map01100 ko:K01935 6.3.3.3 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring Biotin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00934 mlc ko:K02565,ko:K15545 ROK family NA Z1_00936 ynfM ko:K08224 Sugar (and other) transporter NA Z1_00938 tus ko:K10748 DNA replication terminus site-binding protein (Ter protein) NA Z1_00939 fumC ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 ko:K01679 4.2.1.2 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Cushing syndrome : Endocrine and metabolic disease : Human Diseases;Pathways in cancer : Cancer: overview : Human Diseases;Renal cell carcinoma : Cancer: specific types : Human Diseases Z1_00943 add ko00230,ko01100,ko05340,map00230,map01100,map05340 ko:K01488 3.5.4.4 Adenosine/AMP deaminase Purine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Primary immunodeficiency : Immune disease : Human Diseases Z1_00944 yfeH ko:K14347 SBF-like CPA transporter family (DUF4137) NA Z1_00945 ydgJ ko00562,ko01120,map00562,map01120 ko:K16044 1.1.1.371 oxidoreductase YdgJ Inositol phosphate metabolism : Carbohydrate metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_00947 rnfA ko:K03617 Part of a membrane complex involved in electron transport NA Z1_00948 rnfB ko00680,ko01100,ko01120,map00680,map01100,map01120 ko:K00441,ko:K03616 1.12.98.1 Part of a membrane complex involved in electron transport Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_00949 rnfC ko:K03615 Part of a membrane complex involved in electron transport NA Z1_00950 rnfD ko:K00347,ko:K03614 1.6.5.8 Part of a membrane complex involved in electron transport NA Z1_00951 rnfG ko:K03612,ko:K03613 Part of a membrane complex involved in electron transport NA Z1_00952 rnfE ko00540,ko01100,ko03410,map00540,map01100,map03410 ko:K02560,ko:K03613,ko:K10773 2.3.1.243,4.2.99.18 Part of a membrane complex involved in electron transport Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Base excision repair : Replication and repair : Genetic Information Processing Z1_00953 nth ko03410,map03410 ko:K10773 4.2.99.18 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate Base excision repair : Replication and repair : Genetic Information Processing Z1_00954 rnb ko:K01147 3.1.13.1 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction NA Z1_00955 yciH ko03013,map03013 ko:K03113 Translation initiation factor SUI1 RNA transport : Translation : Genetic Information Processing Z1_00956 pyrF ko00240,ko01100,map00240,map01100 ko:K01591 4.1.1.23 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00957 lapB ko:K19804 Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane NA Z1_00958 lapA ko:K08992 Involved in the assembly of lipopolysaccharide (LPS) NA Z1_00959 pgpB ko00564,ko01100,map00564,map01100 ko:K01096 3.1.3.27,3.1.3.4,3.1.3.81,3.6.1.27 Acid phosphatase homologues Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_00960 ribA ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024 ko:K01497 3.5.4.25 Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate Riboflavin metabolism : Metabolism of cofactors and vitamins : Metabolism;Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_00961 metQ ko02010,map02010 ko:K02072,ko:K02073 NLPA lipoprotein ABC transporters : Membrane transport : Environmental Information Processing Z1_00963 acnA ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 ko:K01681 4.2.1.3 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_00965 cysB ko:K13634 Bacterial regulatory helix-turn-helix protein, lysR family NA Z1_00969 sodC ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020 ko:K04565 1.15.1.1 Destroys radicals which are normally produced within the cells and which are toxic to biological systems Peroxisome : Transport and catabolism : Cellular Processes;Longevity regulating pathway - multiple species : Aging : Organismal Systems;Amyotrophic lateral sclerosis : Neurodegenerative disease : Human Diseases;Huntington disease : Neurodegenerative disease : Human Diseases;Prion disease : Neurodegenerative disease : Human Diseases Z1_00970 topA ko:K03168 5.99.1.2 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone NA Z1_00972 sohB ko:K04773,ko:K04774 Peptidase family S49 N-terminal NA Z1_00977 yciO ko:K07566 2.7.7.87 Telomere recombination NA Z1_00979 trpE ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 ko:K01657 4.1.3.27 Anthranilate synthase component I, N terminal region Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Phenazine biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes Z1_00980 trpG ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 ko:K01658,ko:K01664,ko:K13497 2.4.2.18,2.6.1.85,4.1.3.27 Peptidase C26 Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Phenazine biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes Z1_00981 trpD ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 ko:K00766,ko:K13497 2.4.2.18,4.1.3.27 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_00982 trpF ko00260,ko00400,ko00790,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map00790,map01100,map01110,map01130,map01230 ko:K01609,ko:K01696,ko:K01817,ko:K13498,ko:K22100 4.1.1.48,4.2.1.160,4.2.1.20,5.3.1.24 Indole-3-glycerol phosphate synthase Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_00983 trpB ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 ko:K01696 4.2.1.20 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_00984 trpA ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 ko:K01695 4.2.1.20 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_00985 osmY_1 ko:K04065 BON domain NA Z1_00986 ompW ko:K07275 OmpW family NA Z1_00988 sulP ko:K03321 COG0659 Sulfate permease and related transporters (MFS superfamily) NA Z1_00989 ispZ ko:K06190 probably involved in intracellular septation NA Z1_00990 yciA ko01040,map01040 ko:K10806 Thioesterase superfamily Biosynthesis of unsaturated fatty acids : Lipid metabolism : Metabolism Z1_00991 tonB ko:K03832 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins NA Z1_00993 cls ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 ko:K00998,ko:K06131 2.7.8.8 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_00994 yciU ko:K09901 Protein of unknown function, DUF440 NA Z1_00995 ko:K16078 Enterobacterial Ail/Lom protein NA Z1_00996 yaeR ko:K08234 glyoxalase bleomycin resistance protein dioxygenase NA Z1_00997 ycnE ko:K06996 Antibiotic biosynthesis monooxygenase NA Z1_00999 leuE ko:K11250 LysE type translocator NA Z1_01000 ttcA ko:K04075,ko:K14058 6.3.4.19 Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system NA Z1_01001 zntB ko:K03284,ko:K16074 CorA-like Mg2+ transporter protein NA Z1_01002 ko:K09712 Domain of unknown function (DUF4377) NA Z1_01003 ko:K16078 Outer membrane protein beta-barrel domain NA Z1_01004 mppA ko01501,ko02010,ko02024,map01501,map02010,map02024 ko:K02035,ko:K15580 Bacterial extracellular solute-binding proteins, family 5 Middle beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_01005 tpx ko:K11065 1.11.1.15 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides NA Z1_01006 tyrR ko:K03721 PAS domain NA Z1_01008 ycjF ko:K06883,ko:K08990 Domain of unknown function (DUF697) NA Z1_01009 ycjX ko:K06918 YcjX-like family, DUF463 NA Z1_01010 pspD ko:K03971 Phage shock protein PspD (Phageshock_PspD) NA Z1_01011 pspC ko:K03973 PspC domain NA Z1_01012 pspB ko:K03970 Phage shock protein B NA Z1_01013 pspA ko:K03969 PspA/IM30 family NA Z1_01016 sapB ko01503,ko02010,map01503,map02010 ko:K19227 Binding-protein-dependent transport system inner membrane component Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing Z1_01017 sapC ko01503,ko02010,map01503,map02010 ko:K19228 Binding-protein-dependent transport system inner membrane component Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing Z1_01018 sapD ko01503,ko02010,map01503,map02010 ko:K19229 dipeptide ABC transporter, ATP-binding Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing Z1_01019 sapF ko01503,ko02010,map01503,map02010 ko:K19230 ATPases associated with a variety of cellular activities Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing Z1_01020 fabI ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212 ko:K00208 1.3.1.10,1.3.1.9 Enoyl-(Acyl carrier protein) reductase Fatty acid biosynthesis : Lipid metabolism : Metabolism;Prodigiosin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Biotin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;NA : NA : NA;Fatty acid metabolism : Global and overview maps : Metabolism Z1_01021 gst ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 ko:K00799 2.5.1.18 Glutathione S-transferase, C-terminal domain Glutathione metabolism : Metabolism of other amino acids : Metabolism;Metabolism of xenobiotics by cytochrome P450 : Xenobiotics biodegradation and metabolism : Metabolism;Drug metabolism - cytochrome P450 : Xenobiotics biodegradation and metabolism : Metabolism;Drug metabolism - other enzymes : Xenobiotics biodegradation and metabolism : Metabolism;Platinum drug resistance : Drug resistance: antineoplastic : Human Diseases;Pathways in cancer : Cancer: overview : Human Diseases;Chemical carcinogenesis : Cancer: overview : Human Diseases;Hepatocellular carcinoma : Cancer: specific types : Human Diseases;Fluid shear stress and atherosclerosis : Cardiovascular disease : Human Diseases Z1_01022 pdxY ko00750,ko01100,map00750,map01100 ko:K00868 2.7.1.35 Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP Vitamin B6 metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01023 tyrS ko00970,map00970 ko:K01866 6.1.1.1 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing Z1_01024 pdxH ko00750,ko01100,ko01120,map00750,map01100,map01120 ko:K00275 1.4.3.5 pyridoxamine 5'-phosphate oxidase Vitamin B6 metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_01025 anmK ko00520,ko01100,map00520,map01100 ko:K07106,ko:K09001 2.7.1.170,4.2.1.126 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01026 slyB ko:K06077 Glycine zipper 2TM domain NA Z1_01027 slyA ko:K06075 helix_turn_helix multiple antibiotic resistance protein NA Z1_01028 ydhL ko:K06938 Protein of unknown function (DUF1289) NA Z1_01029 gloA ko00620,map00620 ko:K01759 4.4.1.5 Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione Pyruvate metabolism : Carbohydrate metabolism : Metabolism Z1_01030 rnt ko:K03683 Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis NA Z1_01031 grxD ko:K07390 Glutaredoxin NA Z1_01035 Z012_10580 ko:K07090 Sulfite exporter TauE/SafE NA Z1_01036 sodB ko03430,ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map03430,map04013,map04068,map04146,map04211,map04212,map04213,map05016 ko:K03601,ko:K04564 1.15.1.1,3.1.11.6 Destroys radicals which are normally produced within the cells and which are toxic to biological systems Mismatch repair : Replication and repair : Genetic Information Processing;MAPK signaling pathway - fly : Signal transduction : Environmental Information Processing;FoxO signaling pathway : Signal transduction : Environmental Information Processing;Peroxisome : Transport and catabolism : Cellular Processes;Longevity regulating pathway : Aging : Organismal Systems;Longevity regulating pathway - worm : Aging : Organismal Systems;Longevity regulating pathway - multiple species : Aging : Organismal Systems;Huntington disease : Neurodegenerative disease : Human Diseases Z1_01037 purR ko:K02529,ko:K03604 Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression NA Z1_01038 ydhB ko:K10972 Bacterial regulatory helix-turn-helix protein, lysR family NA Z1_01040 cfa ko:K00574,ko:K20238 2.1.1.317,2.1.1.79 Mycolic acid cyclopropane synthetase NA Z1_01041 ribE ko00740,ko01100,ko01110,map00740,map01100,map01110 ko:K00793 2.5.1.9 Lumazine binding domain Riboflavin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_01042 mdtK ko:K03327 Multidrug efflux pump that functions probably as a Na( ) drug antiporter NA Z1_01045 pyk ko00010,ko00230,ko00261,ko00450,ko00620,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00261,map00450,map00620,map00920,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 ko:K00873,ko:K00958 2.7.1.40,2.7.7.4 Belongs to the pyruvate kinase family Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Purine metabolism : Nucleotide metabolism : Metabolism;Monobactam biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism;Glucagon signaling pathway : Endocrine system : Organismal Systems;Type II diabetes mellitus : Endocrine and metabolic disease : Human Diseases;Human papillomavirus infection : Infectious disease: viral : Human Diseases;Viral carcinogenesis : Cancer: overview : Human Diseases;Central carbon metabolism in cancer : Cancer: overview : Human Diseases Z1_01047 gadB ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940 ko:K01580 4.1.1.15 Pyridoxal-dependent decarboxylase conserved domain Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;beta-Alanine metabolism : Metabolism of other amino acids : Metabolism;Taurine and hypotaurine metabolism : Metabolism of other amino acids : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;GABAergic synapse : Nervous system : Organismal Systems;Type I diabetes mellitus : Endocrine and metabolic disease : Human Diseases Z1_01048 cbh ko00120,ko00121,ko01100,map00120,map00121,map01100 ko:K01442 3.5.1.24 Linear amide C-N hydrolases, choloylglycine hydrolase family Primary bile acid biosynthesis : Lipid metabolism : Metabolism;Secondary bile acid biosynthesis : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01049 cbh ko00120,ko00121,ko01100,map00120,map00121,map01100 ko:K01442 3.5.1.24 Linear amide C-N hydrolases, choloylglycine hydrolase family Primary bile acid biosynthesis : Lipid metabolism : Metabolism;Secondary bile acid biosynthesis : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01050 yajI ko:K06078 Lipoprotein leucine-zipper NA Z1_01051 ycfS ko01503,map01503 ko:K16291,ko:K19234,ko:K19235,ko:K19236 L,D-transpeptidase catalytic domain Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases Z1_01052 sufE ko00450,ko01100,map00450,map01100 ko:K02426,ko:K11717 2.8.1.7,4.4.1.16 Fe-S metabolism associated domain Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01053 sufS ko00450,ko01100,map00450,map01100 ko:K01766,ko:K11717 2.8.1.7,4.4.1.16 Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L-selenocysteine. Selenocysteine lyase activity is however unsure in vivo Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01054 sufD ko:K07033,ko:K09015 Uncharacterized protein family (UPF0051) NA Z1_01055 sufC ko:K09013 ATPases associated with a variety of cellular activities NA Z1_01056 sufB ko:K07033,ko:K09014 Uncharacterized protein family (UPF0051) NA Z1_01057 sufA ko:K05997,ko:K13628 Iron-sulphur cluster biosynthesis NA Z1_01059 menI ko00130,ko01100,ko01110,map00130,map01100,map01110 ko:K19222 3.1.2.28 Thioesterase superfamily Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_01061 ydiK ko:K03548 AI-2E family transporter NA Z1_01062 ppsA ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 ko:K01007 2.7.9.2 Phosphoenolpyruvate synthase Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism Z1_01063 ydiA ko:K09773 2.7.11.33,2.7.4.28 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation NA Z1_01064 aroH ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 ko:K01626 2.5.1.54 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism;Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_01066 hxuC ko:K16087 receptor NA Z1_01067 hmuR ko:K16087 Psort location OuterMembrane, score 9.92 NA Z1_01068 hmuS ko02010,map02010 ko:K02016,ko:K07225 Haemin-degrading HemS.ChuX domain ABC transporters : Membrane transport : Environmental Information Processing Z1_01069 hmuT ko02010,map02010 ko:K02016 Periplasmic binding protein ABC transporters : Membrane transport : Environmental Information Processing Z1_01070 hmuU ko02010,map02010 ko:K02015 FecCD transport family ABC transporters : Membrane transport : Environmental Information Processing Z1_01071 hmuV ko00860,ko01100,ko01110,ko02010,map00860,map01100,map01110,map02010 ko:K02013,ko:K06074,ko:K21480 1.14.15.20,3.6.3.33,3.6.3.34 Hemin import ATP-binding protein HmuV Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;ABC transporters : Membrane transport : Environmental Information Processing Z1_01072 lrp_3 ko:K03719,ko:K05800 helix_turn_helix ASNC type NA Z1_01074 ydcR ko02025,map02025 ko:K21023 2.7.7.65 helix_turn_helix gluconate operon transcriptional repressor Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes Z1_01075 cioA ko00190,ko01100,ko02020,map00190,map01100,map02020 ko:K00425 1.10.3.14 to quinol oxidase subunit I K00425 Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing Z1_01076 cioB ko00190,ko01100,ko02020,map00190,map01100,map02020 ko:K00426 1.10.3.14 Cytochrome bd terminal oxidase subunit II Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing Z1_01080 phoH ko:K06217 AAA domain NA Z1_01082 endA ko:K01150 3.1.21.1 Endonuclease I NA Z1_01086 ko:K07474 DNA packaging NA Z1_01107 ko:K21495 Arc-like DNA binding domain NA Z1_01108 ko:K03466 COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins NA Z1_01116 ko:K01449,ko:K21471 3.5.1.28 NLP P60 protein NA Z1_01126 Z012_00755 ko05133,map05133 ko:K07347 usher protein Pertussis : Infectious disease: bacterial : Human Diseases Z1_01127 focC ko:K15540 Pili assembly chaperone NA Z1_01128 fimA ko05133,map05133 ko:K07345 Type-1 fimbrial protein, A Pertussis : Infectious disease: bacterial : Human Diseases Z1_01130 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 ko:K02345 2.7.7.7 DNA polymerase III, theta subunit Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;DNA replication : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing Z1_01131 glnS ko00970,ko01100,map00970,map01100 ko:K01886 6.1.1.18 tRNA synthetases class I (E and Q), anti-codon binding domain Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing;Metabolic pathways : Global and overview maps : Metabolism Z1_01134 fur ko02024,map02024 ko:K03711,ko:K09823 Ferric uptake regulator family Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_01135 fldA ko:K03839 Low-potential electron donor to a number of redox enzymes NA Z1_01137 ybfF ko:K01175 PGAP1-like protein NA Z1_01138 seqA ko:K03645 Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated NA Z1_01139 pgm ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 ko:K01835 5.4.2.2 phosphoglucomutase K01835 Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Purine metabolism : Nucleotide metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Streptomycin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA Z1_01142 ko:K07726 transcriptional regulator NA Z1_01144 ybgI ko00790,ko01100,map00790,map01100 ko:K22391 3.5.4.16 NIF3 (NGG1p interacting factor 3) Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01148 yehL ko:K03924 AAA domain (dynein-related subfamily) NA Z1_01149 molR ko:K01387 3.4.24.3 Domain of unknown function (DUF4132) NA Z1_01150 bcr1 ko:K02030,ko:K07552 drug resistance transporter, Bcr CflA subfamily NA Z1_01152 gltA ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 ko:K01647 2.3.3.1 Citrate synthase, C-terminal domain Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_01153 sdhC ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 ko:K00241 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Oxidative phosphorylation : Energy metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism Z1_01154 sdhD ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 ko:K00242 Membrane-anchoring subunit of succinate dehydrogenase (SDH) Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Oxidative phosphorylation : Energy metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism Z1_01155 sdhA ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 ko:K00239 1.3.5.1,1.3.5.4 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Oxidative phosphorylation : Energy metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Legionellosis : Infectious disease: bacterial : Human Diseases Z1_01156 sdhB ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 ko:K00240,ko:K00245 1.3.5.1,1.3.5.4 2Fe-2S iron-sulfur cluster binding domain Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Oxidative phosphorylation : Energy metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing Z1_01158 sucB ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 ko:K00658 2.3.1.61 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Lysine degradation : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism Z1_01159 sucC ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 ko:K01903 6.2.1.5 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;C5-Branched dibasic acid metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism Z1_01160 sucD ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 ko:K01902,ko:K02381 6.2.1.5 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;C5-Branched dibasic acid metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism Z1_01161 cydA ko00190,ko01100,ko02020,map00190,map01100,map02020 ko:K00425 1.10.3.14 Cytochrome bd terminal oxidase subunit I Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing Z1_01162 cydB ko00190,ko01100,ko02020,map00190,map01100,map02020 ko:K00426 1.10.3.14 cytochrome D ubiquinol oxidase subunit II Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing Z1_01163 ybgT ko00190,ko02020,map00190,map02020 ko:K00424 1.10.3.14 Membrane bound YbgT-like protein Oxidative phosphorylation : Energy metabolism : Metabolism;Two-component system : Signal transduction : Environmental Information Processing Z1_01168 ybgC ko:K07107,ko:K12500 Thioesterase-like superfamily NA Z1_01169 tolQ ko01120,map01120 ko:K03562 MotA/TolQ/ExbB proton channel family Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_01170 tolR ko:K03560 Biopolymer transport protein ExbD/TolR NA Z1_01171 tolA ko:K03646 membrane spanning protein TolA K03646 NA Z1_01172 tolB ko:K03641 Involved in the TonB-independent uptake of proteins NA Z1_01173 pal ko:K03640 OmpA family NA Z1_01174 cpoB ko01503,map01503 ko:K01448 3.5.1.28 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases Z1_01177 ko:K05593 Streptomycin adenylyltransferase NA Z1_01178 pnuC ko:K03811 Nicotinamide mononucleotide transporter NA Z1_01179 aroG ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 ko:K01626 2.5.1.54 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism;Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_01180 gpmA ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 ko:K01834 5.4.2.11 Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism;Glucagon signaling pathway : Endocrine system : Organismal Systems;Central carbon metabolism in cancer : Cancer: overview : Human Diseases Z1_01181 modF ko02010,map02010 ko:K02013,ko:K02028,ko:K05776 3.6.3.21,3.6.3.34 ATPases associated with a variety of cellular activities ABC transporters : Membrane transport : Environmental Information Processing Z1_01182 hpmB ko03070,ko05133,map03070,map05133 ko:K07326,ko:K11017 Haemolysin secretion/activation protein ShlB/FhaC/HecB Bacterial secretion system : Membrane transport : Environmental Information Processing;Pertussis : Infectious disease: bacterial : Human Diseases Z1_01183 ko05133,map05133 ko:K15125 Psort location OuterMembrane, score Pertussis : Infectious disease: bacterial : Human Diseases Z1_01185 ko05133,map05133 ko:K15125 Psort location OuterMembrane, score Pertussis : Infectious disease: bacterial : Human Diseases Z1_01191 modE ko02010,map02010 ko:K02019,ko:K05772 Bacterial regulatory helix-turn-helix protein, lysR family ABC transporters : Membrane transport : Environmental Information Processing Z1_01193 modA ko02010,map02010 ko:K02020 molybdate ABC transporter, periplasmic molybdate-binding protein ABC transporters : Membrane transport : Environmental Information Processing Z1_01194 modB ko02010,map02010 ko:K02017,ko:K02018,ko:K15496 3.6.3.29 Binding-protein-dependent transport system inner membrane component ABC transporters : Membrane transport : Environmental Information Processing Z1_01195 ko02010,ko04976,ko05206,ko05226,map02010,map04976,map05206,map05226 ko:K05657,ko:K05658 3.6.3.44 ATPase activity, coupled to transmembrane movement of substances ABC transporters : Membrane transport : Environmental Information Processing;Bile secretion : Digestive system : Organismal Systems;MicroRNAs in cancer : Cancer: overview : Human Diseases;Gastric cancer : Cancer: specific types : Human Diseases Z1_01197 pgl ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 ko:K07404 3.1.1.31 Lactonase, 7-bladed beta-propeller Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism Z1_01198 bioA ko00780,ko01100,map00780,map01100 ko:K00833 2.6.1.62 Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor Biotin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01199 bioB ko00780,ko01100,map00780,map01100 ko:K01012 2.8.1.6 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism Biotin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01200 bioF ko00780,ko01100,map00780,map01100 ko:K00652,ko:K01012 2.3.1.47,2.8.1.6 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide Biotin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01201 bioC ko00780,ko01100,map00780,map01100 ko:K02169 2.1.1.197 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway Biotin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01202 bioD ko00780,ko01100,map00780,map01100 ko:K01935 6.3.3.3 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring Biotin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01203 uvrB ko03420,map03420 ko:K03702,ko:K08999 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage Nucleotide excision repair : Replication and repair : Genetic Information Processing Z1_01206 moaA ko00790,ko01100,ko04122,map00790,map01100,map04122 ko:K03639 4.1.99.22 Molybdenum cofactor biosynthesis protein A Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing Z1_01207 moaC ko00790,ko01100,ko04122,map00790,map01100,map04122 ko:K03637 4.6.1.17 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing Z1_01208 moaD ko00790,ko01100,ko04122,map00790,map01100,map04122 ko:K03636,ko:K03752,ko:K21142 2.7.7.77,2.8.1.12 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing Z1_01209 moaE ko00790,ko01100,ko04122,map00790,map01100,map04122 ko:K03635 2.8.1.12 MoaE protein Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing Z1_01210 ybhL ko:K06890 Inhibitor of apoptosis-promoting Bax1 NA Z1_01211 ybhR ko:K01992 ABC-2 family transporter protein NA Z1_01212 ybhS ko:K01992 ABC-2 family transporter protein NA Z1_01213 ybhF ko:K01990,ko:K13926 ABC transporter NA Z1_01214 ybhG ko:K01993 Secretion protein NA Z1_01216 rhlE ko03018,map03018 ko:K11927 3.6.4.13 DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA RNA degradation : Folding, sorting and degradation : Genetic Information Processing Z1_01217 dusC ko:K05541 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs NA Z1_01220 sseA ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 ko:K01011 2.8.1.1,2.8.1.2 Rhodanese Homology Domain Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing Z1_01222 dcuD ko:K03326 C4-dicarboxylate anaerobic carrier NA Z1_01223 metC ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 ko:K01739,ko:K01760,ko:K01761 2.5.1.48,4.4.1.11,4.4.1.8 Cys/Met metabolism PLP-dependent enzyme Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_01224 purB2 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 ko:K01756 4.3.2.2 Adenylosuccinate lyase C-terminus Purine metabolism : Nucleotide metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA Z1_01227 dinG ko:K03722 3.6.4.12 helicase NA Z1_01228 dps ko:K04047 Ferritin-like domain NA Z1_01229 rhtA ko:K11939 EamA-like transporter family NA Z1_01230 yvdD ko00230,ko00240,map00230,map00240 ko:K06966 3.2.2.10 Possible lysine decarboxylase Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism Z1_01233 moeB ko00730,ko01100,ko04122,map00730,map01100,map04122 ko:K03148,ko:K21029 2.7.7.73,2.7.7.80 ThiF family Thiamine metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing Z1_01234 moeA ko00790,ko01100,map00790,map01100 ko:K03750 2.10.1.1 Probable molybdopterin binding domain Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01236 folE ko00790,ko01100,map00790,map01100 ko:K00950,ko:K01495 2.7.6.3,3.5.4.16 GTP cyclohydrolase I Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01237 yeiB ko:K07148 Membrane NA Z1_01238 sanA ko:K03748 DUF218 domain NA Z1_01239 maeA ko00620,ko01200,ko02020,map00620,map01200,map02020 ko:K00027 1.1.1.38 malate dehydrogenase (oxaloacetate-decarboxylating) K00027 Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Carbon metabolism : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing Z1_01240 cdd ko00240,ko00983,ko01100,map00240,map00983,map01100 ko:K01489 3.5.4.5 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Drug metabolism - other enzymes : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01242 lrgA ko02020,map02020 ko:K05338,ko:K06518 LrgA family Two-component system : Signal transduction : Environmental Information Processing Z1_01243 metG ko00450,ko00970,map00450,map00970 ko:K01874,ko:K01890,ko:K06878 6.1.1.10,6.1.1.20 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing Z1_01244 mrp ko:K03593 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP NA Z1_01245 udk ko00240,ko00983,ko01100,map00240,map00983,map01100 ko:K00876 2.7.1.48 Phosphoribulokinase / Uridine kinase family Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Drug metabolism - other enzymes : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01246 dcd ko00240,ko01100,map00240,map01100 ko:K01494 3.5.4.13 Belongs to the dCTP deaminase family Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01247 asmA ko:K07289,ko:K07290 AsmA family NA Z1_01248 dcuC ko:K03326 Tripartite ATP-independent periplasmic transporter, DctM component NA Z1_01249 yoaE_1 ko:K03699 Integral membrane protein TerC family NA Z1_01250 gnd ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200 ko:K00033 1.1.1.343,1.1.1.44 Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Glutathione metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism Z1_01251 yeaK ko:K03976,ko:K19055 Aminoacyl-tRNA editing domain NA Z1_01252 yiaY ko00010,ko00071,ko00350,ko00625,ko00626,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map01100,map01110,map01120,map01130,map01220 ko:K13954 1.1.1.1 Iron-containing alcohol dehydrogenase Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Fatty acid degradation : Lipid metabolism : Metabolism;Tyrosine metabolism : Amino acid metabolism : Metabolism;Chloroalkane and chloroalkene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Naphthalene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Degradation of aromatic compounds : Global and overview maps : Metabolism Z1_01253 hisI ko00340,ko00740,ko00790,ko01100,ko01110,ko01230,ko02024,map00340,map00740,map00790,map01100,map01110,map01230,map02024 ko:K01496,ko:K01497,ko:K01523,ko:K01814,ko:K11755 3.5.4.19,3.5.4.25,3.6.1.31,5.3.1.16 Phosphoribosyl-AMP cyclohydrolase Histidine metabolism : Amino acid metabolism : Metabolism;Riboflavin metabolism : Metabolism of cofactors and vitamins : Metabolism;Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism;Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_01254 hisF ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 ko:K01663,ko:K02500,ko:K11755 3.5.4.19,3.6.1.31 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit Histidine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_01255 hisA ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 ko:K01814 5.3.1.16 Tryptophan synthase alpha chain Histidine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_01256 hisH ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 ko:K02501 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR Histidine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_01257 hisB ko00340,ko00350,ko00360,ko00400,ko00401,ko00540,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00540,map00960,map01100,map01110,map01130,map01230 ko:K00013,ko:K00817,ko:K01089,ko:K01693,ko:K03273 1.1.1.23,2.6.1.9,3.1.3.15,3.1.3.82,3.1.3.83,4.2.1.19 Imidazoleglycerol-phosphate dehydratase Histidine metabolism : Amino acid metabolism : Metabolism;Tyrosine metabolism : Amino acid metabolism : Metabolism;Phenylalanine metabolism : Amino acid metabolism : Metabolism;Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Novobiocin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Tropane, piperidine and pyridine alkaloid biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_01258 hisC ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 ko:K00013,ko:K00817 1.1.1.23,2.6.1.9 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily Histidine metabolism : Amino acid metabolism : Metabolism;Tyrosine metabolism : Amino acid metabolism : Metabolism;Phenylalanine metabolism : Amino acid metabolism : Metabolism;Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Novobiocin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Tropane, piperidine and pyridine alkaloid biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_01259 hisD ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 ko:K00013,ko:K15509 1.1.1.23,1.1.1.308 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine Histidine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_01260 hisG ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 ko:K00765 2.4.2.17 ATP phosphoribosyltransferase Histidine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_01263 yliJ ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 ko:K00799 2.5.1.18 Glutathione S-transferase, N-terminal domain protein Glutathione metabolism : Metabolism of other amino acids : Metabolism;Metabolism of xenobiotics by cytochrome P450 : Xenobiotics biodegradation and metabolism : Metabolism;Drug metabolism - cytochrome P450 : Xenobiotics biodegradation and metabolism : Metabolism;Drug metabolism - other enzymes : Xenobiotics biodegradation and metabolism : Metabolism;Platinum drug resistance : Drug resistance: antineoplastic : Human Diseases;Pathways in cancer : Cancer: overview : Human Diseases;Chemical carcinogenesis : Cancer: overview : Human Diseases;Hepatocellular carcinoma : Cancer: specific types : Human Diseases;Fluid shear stress and atherosclerosis : Cardiovascular disease : Human Diseases Z1_01264 dacC ko00550,ko01100,map00550,map01100 ko:K07258 3.4.16.4 penicillin-binding protein 6 precursor (D-alanyl-D-alanine carboxypeptidase fraction C) (DD-pept (DD-carboxypeptidase) (PBP-6)idase) K07258 Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01265 fhs ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 ko:K00288,ko:K01938 1.5.1.5,3.5.4.9,6.3.4.3 Belongs to the formate--tetrahydrofolate ligase family One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism Z1_01266 sdaB ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 ko:K01752 4.3.1.17 Serine dehydratase alpha chain Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_01267 sdaC ko:K03834,ko:K03835,ko:K03837 Tryptophan/tyrosine permease family NA Z1_01268 ybjG ko00550,map00550 ko:K19302 3.6.1.27 Acid phosphatase homologues Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism Z1_01270 grxA ko00230,ko00240,ko01100,map00230,map00240,map01100 ko:K00526,ko:K03674,ko:K03676 1.17.4.1 Glutaredoxin-like domain (DUF836) Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01274 rumB ko:K03212,ko:K03215 2.1.1.189,2.1.1.190 Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA NA Z1_01275 artM ko02010,map02010 ko:K02029,ko:K09998 Binding-protein-dependent transport system inner membrane component ABC transporters : Membrane transport : Environmental Information Processing Z1_01276 artQ ko02010,map02010 ko:K02029,ko:K09999 Binding-protein-dependent transport system inner membrane component ABC transporters : Membrane transport : Environmental Information Processing Z1_01277 artI ko02010,map02010 ko:K09997 Belongs to the bacterial solute-binding protein 3 family ABC transporters : Membrane transport : Environmental Information Processing Z1_01278 artP ko02010,map02010 ko:K10000 AAA domain, putative AbiEii toxin, Type IV TA system ABC transporters : Membrane transport : Environmental Information Processing Z1_01281 ybjD ko:K07459 Protein of unknown function (DUF2813) NA Z1_01282 macA ko:K02005,ko:K13888 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family NA Z1_01283 macB ko02010,map02010 ko:K02003,ko:K02004,ko:K05685 Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides ABC transporters : Membrane transport : Environmental Information Processing Z1_01284 cspD ko:K03704 Cold shock protein domain NA Z1_01285 clpS ko:K06891 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation NA Z1_01286 clpA ko:K03694 ATP-dependent Clp protease ATP-binding subunit ClpA NA Z1_01287 infA ko:K02518 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex NA Z1_01288 aat ko:K00684 2.3.2.6 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine NA Z1_01289 cydC ko02010,map02010 ko:K16012 thiol reductant ABC exporter, CydC subunit ABC transporters : Membrane transport : Environmental Information Processing Z1_01290 cydD ko02010,map02010 ko:K16013 thiol reductant ABC exporter, CydD subunit ABC transporters : Membrane transport : Environmental Information Processing Z1_01291 trxB ko00450,ko04621,ko05418,map00450,map04621,map05418 ko:K00384,ko:K03671 1.8.1.9 Pyridine nucleotide-disulphide oxidoreductase Selenocompound metabolism : Metabolism of other amino acids : Metabolism;NOD-like receptor signaling pathway : Immune system : Organismal Systems;Fluid shear stress and atherosclerosis : Cardiovascular disease : Human Diseases Z1_01292 lrp ko:K03719 Lrp/AsnC ligand binding domain NA Z1_01293 ftsK ko:K03466 cell division protein NA Z1_01294 lolA ko:K03634 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) NA Z1_01295 rarA ko:K07478 polynucleotide enzyme with nucleotide triphosphate hydrolase domain K07478 NA Z1_01296 serS ko00970,map00970 ko:K01875 6.1.1.11 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing Z1_01298 allD ko00230,ko01120,map00230,map01120 ko:K00073 1.1.1.350 Belongs to the LDH2 MDH2 oxidoreductase family Purine metabolism : Nucleotide metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_01300 pflA ko:K04069 1.97.1.4 Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine NA Z1_01301 pflB ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120 ko:K00656 2.3.1.54 formate acetyltransferase Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_01302 focA ko:K03459,ko:K06212,ko:K21993 Formate/nitrite transporter NA Z1_01303 ycaO ko:K09136 YcaO cyclodehydratase, ATP-ad Mg2+-binding NA Z1_01304 ansB ko00220,ko00250,ko00460,ko00471,ko01100,ko01110,ko02020,map00220,map00250,map00460,map00471,map01100,map01110,map02020 ko:K01424,ko:K05597 3.5.1.1,3.5.1.38 Asparaginase Arginine biosynthesis : Amino acid metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Cyanoamino acid metabolism : Metabolism of other amino acids : Metabolism;D-Glutamine and D-glutamate metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing Z1_01307 serC ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 ko:K00831 2.6.1.52 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Vitamin B6 metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_01308 aroA ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 ko:K00800 2.5.1.19 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_01309 cmk ko00240,ko00400,ko00410,ko00740,ko00770,ko00900,ko01100,ko01110,ko01130,ko01230,ko03010,map00240,map00400,map00410,map00740,map00770,map00900,map01100,map01110,map01130,map01230,map03010 ko:K00800,ko:K00945,ko:K02945,ko:K03527,ko:K03977,ko:K11753,ko:K13799 1.17.7.4,2.5.1.19,2.7.1.26,2.7.4.25,2.7.7.2,6.3.2.1 Belongs to the cytidylate kinase family. Type 1 subfamily Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;beta-Alanine metabolism : Metabolism of other amino acids : Metabolism;Riboflavin metabolism : Metabolism of cofactors and vitamins : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Terpenoid backbone biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism;Ribosome : Translation : Genetic Information Processing Z1_01310 rpsA ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010 ko:K02945,ko:K03527 1.17.7.4 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence Terpenoid backbone biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Ribosome : Translation : Genetic Information Processing Z1_01311 himD ko:K05788 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control NA Z1_01312 ycaI ko:K02238 DNA internalization-related competence protein ComEC Rec2 NA Z1_01313 msbA ko02010,map02010 ko:K02021,ko:K06147,ko:K11085 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation ABC transporters : Membrane transport : Environmental Information Processing Z1_01314 lpxK ko00540,ko01100,map00540,map01100 ko:K00912 2.7.1.130 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01315 cspA ko:K03704 'Cold-shock' DNA-binding domain NA Z1_01316 ycaR ko00540,ko01100,map00540,map01100 ko:K00912,ko:K09791 2.7.1.130 Trm112p-like protein Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01317 kdsB ko00540,ko01100,map00540,map01100 ko:K00979 2.7.7.38 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01319 cmoM ko:K06219,ko:K20444 Catalyzes the methylation of 5-carboxymethoxyuridine (cmo5U) to form 5-methoxycarbonylmethoxyuridine (mcmo5U) at position 34 in tRNAs NA Z1_01320 mukF ko:K03633 Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity NA Z1_01321 mukE ko02025,map02025 ko:K03804,ko:K21006 Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes Z1_01322 mukB ko00130,ko01110,map00130,map01110 ko:K03632,ko:K18286 3.5.4.40 cell division protein MukB K03632 Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_01323 cat ko:K19271 2.3.1.28 This enzyme is an effector of chloramphenicol resistance in bacteria NA Z1_01324 aphA ko00740,ko01100,map00740,map01100 ko:K03788 3.1.3.2 HAD superfamily, subfamily IIIB (Acid phosphatase) Riboflavin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01325 ycbB ko:K21470 Putative peptidoglycan binding domain NA Z1_01326 ycbK ko:K02395 Bacterial protein of unknown function (DUF882) NA Z1_01327 ycbL ko00620,map00620 ko:K01069 3.1.2.6 COG0491 Zn-dependent hydrolases, including glyoxylases Pyruvate metabolism : Carbohydrate metabolism : Metabolism Z1_01328 ko02025,ko03070,map02025,map03070 ko:K06887,ko:K11903 VI_effect_Hcp1 type VI secretion system effector, Hcp1 family protein Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes;Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_01329 ko:K11896 Type VI secretion system, TssF NA Z1_01330 ko:K11911 ImpA, N-terminal, type VI secretion system NA Z1_01331 icmF ko02025,ko03070,map02025,map03070 ko:K11891,ko:K12210 ImcF-related N-terminal domain Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes;Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_01332 vasJ ko:K11910 Type VI secretion, EvfE, EvfF, ImpA, BimE, VC_A0119, VasJ NA Z1_01333 vasI ko:K11909 Type VI secretion system VasI, EvfG, VC_A0118 NA Z1_01335 clpV ko01100,ko02025,ko03070,map01100,map02025,map03070 ko:K03696,ko:K11907 ATPase family associated with various cellular activities (AAA) Metabolic pathways : Global and overview maps : Metabolism;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes;Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_01336 vasF ko03070,map03070 ko:K11892 Type VI secretion system protein DotU Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_01337 impJ ko02025,map02025 ko:K11893 Bacterial Type VI secretion, VC_A0110, EvfL, ImpJ, VasE Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes Z1_01338 vasD ko03070,map03070 ko:K11906 Type VI secretion lipoprotein, VasD, EvfM, TssJ, VC_A0113 Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_01339 impI ko02025,ko03070,map02025,map03070 ko:K11894,ko:K11913 conserved protein, contains FHA domain Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes;Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_01340 impH ko02025,map02025 ko:K11895 Type VI secretion, TssG Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes Z1_01341 vasA ko:K11896 Type VI secretion system, TssF NA Z1_01342 ko:K11905 Gene 25-like lysozyme NA Z1_01343 evpB ko02025,map02025 ko:K11900 Type VI secretion protein, EvpB/VC_A0108, tail sheath Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes Z1_01344 tssB ko02025,map02025 ko:K11901 Type VI secretion system, VipA, VC_A0107 or Hcp2 Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes Z1_01345 ybaN ko:K09790 Protein of unknown function (DUF454) NA Z1_01347 tmcA ko00330,ko01100,ko04216,map00330,map01100,map04216 ko:K00657,ko:K06957 2.3.1.193,2.3.1.57 Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) Arginine and proline metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Ferroptosis : Cell growth and death : Cellular Processes Z1_01349 ypfJ ko:K07054 Putative neutral zinc metallopeptidase NA Z1_01351 bamC ko:K07287 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane NA Z1_01353 gcvR ko02026,map02026 ko:K03567 ACT domain Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes Z1_01354 bcp ko:K03564 1.11.1.15 SCO1/SenC NA Z1_01355 perM ko:K03548 AI-2E family transporter NA Z1_01357 arsC ko:K00537 1.20.4.1 ArsC family NA Z1_01358 nupG ko01501,map01501 ko:K03289,ko:K03301,ko:K08218,ko:K11537 Nucleoside H+ symporter beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases Z1_01359 hda ko02020,ko04112,map02020,map04112 ko:K02313,ko:K10763 protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for Two-component system : Signal transduction : Environmental Information Processing;Cell cycle - Caulobacter : Cell growth and death : Cellular Processes Z1_01360 ybdG ko:K16053 Mechanosensitive ion channel NA Z1_01361 uraA ko:K02824,ko:K16345 Permease family NA Z1_01362 upp ko00240,ko01100,map00240,map01100 ko:K00761 2.4.2.9 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01363 purM ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 ko:K01933,ko:K11788 6.3.3.1,6.3.4.13 AIR synthase related protein, N-terminal domain Purine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA Z1_01364 purN ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 ko:K11175 2.1.2.2 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate Purine metabolism : Nucleotide metabolism : Metabolism;One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA Z1_01365 speG ko00330,ko01100,ko04216,map00330,map01100,map04216 ko:K00657 2.3.1.57 Acetyltransferase (GNAT) domain Arginine and proline metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Ferroptosis : Cell growth and death : Cellular Processes Z1_01367 ppx ko00230,map00230 ko:K01524 3.6.1.11,3.6.1.40 Ppx/GppA phosphatase family Purine metabolism : Nucleotide metabolism : Metabolism Z1_01368 mgtE ko:K06213 Acts as a magnesium transporter NA Z1_01370 proP ko:K03762 Major facilitator superfamily NA Z1_01372 dtpA ko:K03305 POT family NA Z1_01373 mdtA ko02020,map02020 ko:K07799 Barrel-sandwich domain of CusB or HlyD membrane-fusion Two-component system : Signal transduction : Environmental Information Processing Z1_01374 mdtB ko02020,map02020 ko:K03296,ko:K07788,ko:K07789 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family Two-component system : Signal transduction : Environmental Information Processing Z1_01375 mdtC ko02020,map02020 ko:K03296,ko:K07788,ko:K07789 AcrB/AcrD/AcrF family Two-component system : Signal transduction : Environmental Information Processing Z1_01378 yegQ ko05120,map05120 ko:K08303 Peptidase family U32 Epithelial cell signaling in Helicobacter pylori infection : Infectious disease: bacterial : Human Diseases Z1_01379 yegS ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 ko:K07029 2.7.1.107 Lipid kinase Glycerolipid metabolism : Lipid metabolism : Metabolism;Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_01380 fbaB ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 ko:K11645 4.1.2.13 DeoC/LacD family aldolase Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_01381 thiD ko00730,ko01100,map00730,map01100 ko:K00941 2.7.1.49,2.7.4.7 Phosphomethylpyrimidine kinase Thiamine metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01383 pagP ko01503,ko05133,map01503,map05133 ko:K12973 2.3.1.251 Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases;Pertussis : Infectious disease: bacterial : Human Diseases Z1_01384 pheP ko:K03293,ko:K11732,ko:K11734 Amino acid permease NA Z1_01386 marA ko01503,map01503 ko:K13632 Bacterial regulatory helix-turn-helix proteins, AraC family Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases Z1_01388 brnQ ko:K03311 Component of the transport system for branched-chain amino acids NA Z1_01389 amiD ko:K03806,ko:K11066 3.5.1.28 Ami_2 NA Z1_01390 yaaJ ko:K03310 Sodium:alanine symporter family NA Z1_01391 holE ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 ko:K02345 2.7.7.7 DNA polymerase III, theta subunit Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;DNA replication : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing Z1_01393 yoaH ko:K09917 Uncharacterised protein family (UPF0181) NA Z1_01394 pabB ko00790,map00790 ko:K01665,ko:K13950 2.6.1.85 synthase component I Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism Z1_01396 sdaA ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 ko:K01752 4.3.1.17 Serine dehydratase beta chain Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_01399 rrmA ko:K00563 2.1.1.187 Methyltransferase domain NA Z1_01400 psiE ko:K13256 Phosphate-starvation-inducible E NA Z1_01401 uspF ko:K11932,ko:K14061 Universal stress protein family NA Z1_01402 ko00790,map00790 ko:K06897 2.5.1.105 Metallo-beta-lactamase superfamily Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism Z1_01403 uspF ko:K11932,ko:K14061 Universal stress protein NA Z1_01404 cycA ko:K03293,ko:K11737 Amino acid permease NA Z1_01410 putP ko:K11928 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family NA Z1_01411 putA ko00071,ko00250,ko00280,ko00330,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00250,map00280,map00330,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 ko:K00249,ko:K00294,ko:K13821 1.2.1.88,1.3.8.7,1.5.5.2 Oxidizes proline to glutamate for use as a carbon and nitrogen source Fatty acid degradation : Lipid metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Valine, leucine and isoleucine degradation : Amino acid metabolism : Metabolism;Arginine and proline metabolism : Amino acid metabolism : Metabolism;beta-Alanine metabolism : Metabolism of other amino acids : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism;PPAR signaling pathway : Endocrine system : Organismal Systems Z1_01412 fliZ ko02026,map02026 ko:K02425 Phage integrase, N-terminal SAM-like domain Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes Z1_01413 fliA ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 ko:K02405 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes Two-component system : Signal transduction : Environmental Information Processing;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Flagellar assembly : Cell motility : Cellular Processes;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes Z1_01414 fliC ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 ko:K02406 Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella Two-component system : Signal transduction : Environmental Information Processing;Flagellar assembly : Cell motility : Cellular Processes;NOD-like receptor signaling pathway : Immune system : Organismal Systems;Plant-pathogen interaction : Environmental adaptation : Organismal Systems;Salmonella infection : Infectious disease: bacterial : Human Diseases;Legionellosis : Infectious disease: bacterial : Human Diseases Z1_01415 fliC ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 ko:K02406 Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella Two-component system : Signal transduction : Environmental Information Processing;Flagellar assembly : Cell motility : Cellular Processes;NOD-like receptor signaling pathway : Immune system : Organismal Systems;Plant-pathogen interaction : Environmental adaptation : Organismal Systems;Salmonella infection : Infectious disease: bacterial : Human Diseases;Legionellosis : Infectious disease: bacterial : Human Diseases Z1_01416 fliD ko02040,map02040 ko:K02407 Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end Flagellar assembly : Cell motility : Cellular Processes Z1_01417 fliS ko02040,map02040 ko:K02422 Flagellar protein FliS Flagellar assembly : Cell motility : Cellular Processes Z1_01418 fliT ko02040,map02040 ko:K02423 Flagellar protein FliT Flagellar assembly : Cell motility : Cellular Processes Z1_01423 fliE ko02040,map02040 ko:K02408 Flagellar hook-basal body complex protein FliE Flagellar assembly : Cell motility : Cellular Processes Z1_01425 fliG ko02030,ko02040,map02030,map02040 ko:K02410 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation Bacterial chemotaxis : Cell motility : Cellular Processes;Flagellar assembly : Cell motility : Cellular Processes Z1_01426 fliH ko02040,map02040 ko:K02411 Flagellar assembly protein FliH Flagellar assembly : Cell motility : Cellular Processes Z1_01427 fliI ko02040,map02040 ko:K02412 3.6.3.14 ATP synthase alpha/beta family, nucleotide-binding domain Flagellar assembly : Cell motility : Cellular Processes Z1_01428 fliJ ko02040,map02040 ko:K02413 Flagellar protein that affects chemotactic events Flagellar assembly : Cell motility : Cellular Processes Z1_01429 fliK ko02040,map02040 ko:K02414 Flagellar hook-length control protein FliK Flagellar assembly : Cell motility : Cellular Processes Z1_01430 fliL ko:K02415 Controls the rotational direction of flagella during chemotaxis NA Z1_01431 fliM ko02030,ko02040,map02030,map02040 ko:K02416 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation Bacterial chemotaxis : Cell motility : Cellular Processes;Flagellar assembly : Cell motility : Cellular Processes Z1_01432 fliN ko02030,ko02040,map02030,map02040 ko:K02417 FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation Bacterial chemotaxis : Cell motility : Cellular Processes;Flagellar assembly : Cell motility : Cellular Processes Z1_01433 fliO ko02040,map02040 ko:K02418 Flagellar biosynthesis protein, FliO Flagellar assembly : Cell motility : Cellular Processes Z1_01434 fliP ko02040,ko03070,map02040,map03070 ko:K02419,ko:K03226 Plays a role in the flagellum-specific transport system Flagellar assembly : Cell motility : Cellular Processes;Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_01435 fliQ ko02040,map02040 ko:K02420 Role in flagellar biosynthesis Flagellar assembly : Cell motility : Cellular Processes Z1_01436 fliR ko02040,map02040 ko:K02421 Role in flagellar biosynthesis Flagellar assembly : Cell motility : Cellular Processes Z1_01438 flgL ko02040,map02040 ko:K02397 Bacterial flagellin N-terminal helical region Flagellar assembly : Cell motility : Cellular Processes Z1_01439 flgK ko02040,map02040 ko:K02396 flagellar hook-associated protein Flagellar assembly : Cell motility : Cellular Processes Z1_01440 flgJ ko01503,map01503 ko:K01448,ko:K02395 3.5.1.28 Flagellar rod assembly protein muramidase FlgJ Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases Z1_01442 flgH ko02040,map02040 ko:K02393 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation Flagellar assembly : Cell motility : Cellular Processes Z1_01443 flgG ko02040,map02040 ko:K02392 Belongs to the flagella basal body rod proteins family Flagellar assembly : Cell motility : Cellular Processes Z1_01444 flgF ko02040,map02040 ko:K02391 flagellar basal body Flagellar assembly : Cell motility : Cellular Processes Z1_01446 flgD ko02040,map02040 ko:K02389,ko:K02390 Required for flagellar hook formation. May act as a scaffolding protein Flagellar assembly : Cell motility : Cellular Processes Z1_01447 flgC ko02040,map02040 ko:K02388 Flagellar basal body rod FlgEFG protein C-terminal Flagellar assembly : Cell motility : Cellular Processes Z1_01448 flgB ko02040,map02040 ko:K02387 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body Flagellar assembly : Cell motility : Cellular Processes Z1_01449 flgA ko02040,map02040 ko:K02279,ko:K02386 Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly Flagellar assembly : Cell motility : Cellular Processes Z1_01450 flgM ko02020,ko02025,ko02026,ko02040,map02020,map02025,map02026,map02040 ko:K02398 Anti-sigma-28 factor, FlgM Two-component system : Signal transduction : Environmental Information Processing;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Flagellar assembly : Cell motility : Cellular Processes Z1_01451 flgN ko02040,map02040 ko:K02399 FlgN protein Flagellar assembly : Cell motility : Cellular Processes Z1_01453 flhA ko02040,map02040 ko:K02400 flagellar biosynthesis protein FlhA Flagellar assembly : Cell motility : Cellular Processes Z1_01454 flhB ko02020,ko02030,ko02040,ko03070,map02020,map02030,map02040,map03070 ko:K02401,ko:K02556,ko:K03229,ko:K04061,ko:K13820,ko:K22510 Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin Two-component system : Signal transduction : Environmental Information Processing;Bacterial chemotaxis : Cell motility : Cellular Processes;Flagellar assembly : Cell motility : Cellular Processes;Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_01455 cheZ ko02030,map02030 ko:K03414 Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) Bacterial chemotaxis : Cell motility : Cellular Processes Z1_01457 cheB ko02020,ko02030,map02020,map02030 ko:K03412 3.1.1.61,3.5.1.44 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR Two-component system : Signal transduction : Environmental Information Processing;Bacterial chemotaxis : Cell motility : Cellular Processes Z1_01458 cheR ko02020,ko02030,map02020,map02030 ko:K00575 2.1.1.80 chemotaxis protein methyltransferase Two-component system : Signal transduction : Environmental Information Processing;Bacterial chemotaxis : Cell motility : Cellular Processes Z1_01459 tap ko02020,ko02030,map02020,map02030 ko:K03406,ko:K05874,ko:K05875,ko:K05877 chemotaxis, protein Two-component system : Signal transduction : Environmental Information Processing;Bacterial chemotaxis : Cell motility : Cellular Processes Z1_01460 tsr ko02020,ko02030,map02020,map02030 ko:K03406,ko:K05874,ko:K05875,ko:K05877 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Two-component system : Signal transduction : Environmental Information Processing;Bacterial chemotaxis : Cell motility : Cellular Processes Z1_01461 cheW ko02020,ko02030,map02020,map02030 ko:K03408 Two component signalling adaptor domain Two-component system : Signal transduction : Environmental Information Processing;Bacterial chemotaxis : Cell motility : Cellular Processes Z1_01462 cheA ko02020,ko02025,ko02030,map02020,map02025,map02030 ko:K02487,ko:K03407,ko:K06596 2.7.13.3 Two component signalling adaptor domain Two-component system : Signal transduction : Environmental Information Processing;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes;Bacterial chemotaxis : Cell motility : Cellular Processes Z1_01463 motB ko02030,ko02040,map02030,map02040 ko:K02557 Membrane MotB of proton-channel complex MotA/MotB Bacterial chemotaxis : Cell motility : Cellular Processes;Flagellar assembly : Cell motility : Cellular Processes Z1_01464 motA ko02020,ko02030,ko02040,map02020,map02030,map02040 ko:K02556 MotA/TolQ/ExbB proton channel family Two-component system : Signal transduction : Environmental Information Processing;Bacterial chemotaxis : Cell motility : Cellular Processes;Flagellar assembly : Cell motility : Cellular Processes Z1_01465 flhC ko02020,ko02024,ko02026,ko02040,map02020,map02024,map02026,map02040 ko:K02402 Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways Two-component system : Signal transduction : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Flagellar assembly : Cell motility : Cellular Processes Z1_01466 flhD ko02020,ko02024,ko02026,ko02040,map02020,map02024,map02026,map02040 ko:K02403 Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways Two-component system : Signal transduction : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Flagellar assembly : Cell motility : Cellular Processes Z1_01468 mgtC ko:K07507 MgtC family NA Z1_01471 cspA ko:K03704 'Cold-shock' DNA-binding domain NA Z1_01477 pyrC ko00240,ko01100,map00240,map01100 ko:K01465 3.5.2.3 dihydroorotase Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01478 bssS ko:K12148 BssS protein family NA Z1_01480 ttrA ko00920,ko01120,ko02020,map00920,map01120,map02020 ko:K08357 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family Sulfur metabolism : Energy metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing Z1_01481 ttrC ko00920,ko01120,ko02020,map00920,map01120,map02020 ko:K08359 Polysulphide reductase, NrfD Sulfur metabolism : Energy metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing Z1_01482 ttrB ko00920,ko01120,ko02020,map00920,map01120,map02020 ko:K08358 4Fe-4S dicluster domain Sulfur metabolism : Energy metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing Z1_01483 ttrS ko02010,ko02020,map02010,map02020 ko:K02044,ko:K13040 2.7.13.3 ABC transporter, phosphonate, periplasmic substrate-binding protein ABC transporters : Membrane transport : Environmental Information Processing;Two-component system : Signal transduction : Environmental Information Processing Z1_01484 ttrR ko02020,map02020 ko:K13041 helix_turn_helix, Lux Regulon Two-component system : Signal transduction : Environmental Information Processing Z1_01485 ttrR ko02020,map02020 ko:K13041 helix_turn_helix, Lux Regulon Two-component system : Signal transduction : Environmental Information Processing Z1_01486 lpxL ko00540,ko01100,map00540,map01100 ko:K02517,ko:K02560,ko:K12974 2.3.1.241,2.3.1.242,2.3.1.243 Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (lauroyl)-lipid IV(A) Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01487 mdtG ko:K05820,ko:K08161 MFS_1 like family NA Z1_01488 dtpT ko:K03305 POT family NA Z1_01491 ko:K01073 3.1.2.20 Thioesterase superfamily NA Z1_01493 cat ko:K00638,ko:K18234 2.3.1.28 Hexapeptide repeat of succinyl-transferase NA Z1_01494 namA ko:K00354 1.6.99.1 NADH:flavin oxidoreductase / NADH oxidase family NA Z1_01502 dat ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100 ko:K00824 2.6.1.21 Amino-transferase class IV Lysine degradation : Amino acid metabolism : Metabolism;Arginine and proline metabolism : Amino acid metabolism : Metabolism;Phenylalanine metabolism : Amino acid metabolism : Metabolism;D-Arginine and D-ornithine metabolism : Metabolism of other amino acids : Metabolism;D-Alanine metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01503 hdeD ko:K21908 Short repeat of unknown function (DUF308) NA Z1_01504 ybdG ko:K16053 Mechanosensitive ion channel NA Z1_01505 dmsA ko00920,map00920 ko:K07306 1.8.5.3 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family Sulfur metabolism : Energy metabolism : Metabolism Z1_01506 dmsB ko00920,map00920 ko:K07307 Dimethylsulfoxide reductase, chain B Sulfur metabolism : Energy metabolism : Metabolism Z1_01507 dmsC ko00920,map00920 ko:K07308 DMSO reductase anchor subunit (DmsC) Sulfur metabolism : Energy metabolism : Metabolism Z1_01525 ko:K14744 Bacteriophage Rz lysis protein NA Z1_01530 trpS ko00970,map00970 ko:K01867 6.1.1.2 Tryptophanyl-tRNA synthetase Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing Z1_01535 rcsD ko00230,ko02020,ko02024,ko02025,ko02026,ko04113,ko04213,map00230,map02020,map02024,map02025,map02026,map04113,map04213 ko:K01768,ko:K07676,ko:K07687,ko:K10715,ko:K20976 2.7.13.3,4.6.1.1 Hpt domain Purine metabolism : Nucleotide metabolism : Metabolism;Two-component system : Signal transduction : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Meiosis - yeast : Cell growth and death : Cellular Processes;Longevity regulating pathway - multiple species : Aging : Organismal Systems Z1_01536 rcsB ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 ko:K02282,ko:K07687,ko:K07689,ko:K20264 Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator that binds to regulatory DNA regions Two-component system : Signal transduction : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes Z1_01537 rcsC ko02020,ko02026,map02020,map02026 ko:K07677 2.7.13.3 Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane- associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB Two-component system : Signal transduction : Environmental Information Processing;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes Z1_01538 gyrA ko:K02469,ko:K02621 5.99.1.3 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner NA Z1_01539 ubiG ko00130,ko01100,ko01110,map00130,map01100,map01110 ko:K00568 2.1.1.222,2.1.1.64 O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_01540 nrdA ko00230,ko00240,ko01100,map00230,map00240,map01100 ko:K00525 1.17.4.1 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01541 nrdB ko00230,ko00240,ko01100,map00230,map00240,map01100 ko:K00526 1.17.4.1 Ribonucleotide reductase, small chain Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01542 yfaE ko00520,map00520 ko:K00523,ko:K04755,ko:K08952,ko:K08953,ko:K08954,ko:K11107 1.17.1.1 2Fe-2S iron-sulfur cluster binding domain Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism Z1_01545 tyrP ko:K03834,ko:K03835,ko:K03837 Transmembrane amino acid transporter protein NA Z1_01547 ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014 ko:K03781 1.11.1.6 Catalase Tryptophan metabolism : Amino acid metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;MAPK signaling pathway - yeast : Signal transduction : Environmental Information Processing;MAPK signaling pathway - plant : Signal transduction : Environmental Information Processing;FoxO signaling pathway : Signal transduction : Environmental Information Processing;Peroxisome : Transport and catabolism : Cellular Processes;Longevity regulating pathway : Aging : Organismal Systems;Longevity regulating pathway - worm : Aging : Organismal Systems;Longevity regulating pathway - multiple species : Aging : Organismal Systems;Amyotrophic lateral sclerosis : Neurodegenerative disease : Human Diseases Z1_01548 menE ko00130,ko01100,ko01110,map00130,map01100,map01110 ko:K01911,ko:K02549 4.2.1.113,6.2.1.26 AMP-binding enzyme C-terminal domain Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_01549 menC ko00130,ko01100,ko01110,map00130,map01100,map01110 ko:K02549 4.2.1.113 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_01550 menB ko00130,ko01100,ko01110,map00130,map01100,map01110 ko:K01661 4.1.3.36 Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_01551 menH ko00130,ko01100,ko01110,map00130,map01100,map01110 ko:K08680 4.2.99.20 Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_01553 menF ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130 ko:K02361,ko:K02552 5.4.4.2 Isochorismate synthase Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Biosynthesis of siderophore group nonribosomal peptides : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA Z1_01556 nuoN ko00190,ko01100,map00190,map01100 ko:K00343 1.6.5.3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01557 nuoM ko00190,ko01100,map00190,map01100 ko:K00342 1.6.5.3 Proton-conducting membrane transporter Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01558 nuoL ko00190,ko01100,map00190,map01100 ko:K00341 1.6.5.3 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01559 nuoK ko00190,ko01100,map00190,map01100 ko:K00340 1.6.5.3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01560 nuoJ ko00190,ko01100,map00190,map01100 ko:K00339 1.6.5.3 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01561 nuoI ko00190,ko01100,map00190,map01100 ko:K00338 1.6.5.3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01562 nuoH ko00190,ko01100,map00190,map01100 ko:K00337 1.6.5.3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01563 nuoG ko00190,ko01100,map00190,map01100 ko:K00336 1.6.5.3 NADH dehydrogenase Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01564 nuoF ko00190,ko01100,map00190,map01100 ko:K00335 1.6.5.3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01565 nuoE ko00190,ko01100,map00190,map01100 ko:K00334 1.6.5.3 Thioredoxin-like [2Fe-2S] ferredoxin Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01566 nuoC ko00190,ko01100,map00190,map01100 ko:K00332,ko:K00333,ko:K13378,ko:K13380 1.6.5.3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01567 nuoB ko00190,ko01100,map00190,map01100 ko:K00331,ko:K13380 1.6.5.3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01568 nuoA ko00190,ko01100,map00190,map01100 ko:K00330 1.6.5.3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01570 alaA ko00220,ko00250,ko00290,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00220,map00250,map00290,map00710,map01100,map01110,map01120,map01130,map01200,map01210,map01230 ko:K00814,ko:K14260 2.6.1.2,2.6.1.66 Aminotransferase class I and II Arginine biosynthesis : Amino acid metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Valine, leucine and isoleucine biosynthesis : Amino acid metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_01571 yfbR ko00240,ko01100,map00240,map01100 ko:K08722 3.1.3.89 Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01572 yfbS ko:K03281,ko:K03319,ko:K07085,ko:K14445 Tripartite ATP-independent periplasmic transporter, DctM component NA Z1_01573 yfbT ko:K19270 3.1.3.23 Haloacid dehalogenase-like hydrolase NA Z1_01574 yfbU ko:K09161 YfbU domain NA Z1_01575 yfbV ko:K09899 Protein of unknown function, DUF412 NA Z1_01576 ackA ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 ko:K00925 2.7.2.1 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction Taurine and hypotaurine metabolism : Metabolism of other amino acids : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism Z1_01577 pta ko00430,ko00620,ko00640,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00710,map00720,map01100,map01120,map01200 ko:K00029,ko:K13788 1.1.1.40,2.3.1.8 phosphate acetyltransferase Taurine and hypotaurine metabolism : Metabolism of other amino acids : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism Z1_01578 gmhB ko00300,ko00340,ko00540,ko00550,ko01100,ko01110,ko01230,ko01502,map00300,map00340,map00540,map00550,map01100,map01110,map01230,map01502 ko:K01089,ko:K01929,ko:K03273 3.1.3.15,3.1.3.82,3.1.3.83,4.2.1.19,6.3.2.10 Polynucleotide kinase 3 phosphatase Lysine biosynthesis : Amino acid metabolism : Metabolism;Histidine metabolism : Amino acid metabolism : Metabolism;Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism;Vancomycin resistance : Drug resistance: antimicrobial : Human Diseases Z1_01579 metN ko02010,map02010 ko:K02071 Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system ABC transporters : Membrane transport : Environmental Information Processing Z1_01580 metI ko02010,map02010 ko:K02072 Binding-protein-dependent transport system inner membrane component ABC transporters : Membrane transport : Environmental Information Processing Z1_01581 metQ ko02010,map02010 ko:K02072,ko:K02073 Belongs to the nlpA lipoprotein family ABC transporters : Membrane transport : Environmental Information Processing Z1_01582 rcsF ko02020,map02020 ko:K06080 Essential component of the Rcs signaling system, which controls transcription of numerous genes. Plays a role in signal transduction from the cell surface to the histidine kinase RcsC. May detect outer membrane defects Two-component system : Signal transduction : Environmental Information Processing Z1_01585 cutF ko01503,map01503 ko:K06079 NlpE C-terminal OB domain Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases Z1_01586 rof ko:K19000 Modulator of Rho-dependent transcription termination (ROF) NA Z1_01587 tilS ko:K04075,ko:K14058 6.3.4.19 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine NA Z1_01589 accA ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 ko:K01962,ko:K01963 2.1.3.15,6.4.1.2 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA Fatty acid biosynthesis : Lipid metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism Z1_01590 dnaE ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 ko:K02337 2.7.7.7 Bacterial DNA polymerase III alpha subunit Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;DNA replication : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing Z1_01591 rnhB ko03030,map03030 ko:K03470 3.1.26.4 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids DNA replication : Replication and repair : Genetic Information Processing Z1_01592 lpxB ko00540,ko01100,map00540,map01100 ko:K00748 2.4.1.182 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01593 lpxA ko00540,ko01100,ko01503,map00540,map01100,map01503 ko:K00677 2.3.1.129 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases Z1_01594 fabZ ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 ko:K02372 4.2.1.59 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs Fatty acid biosynthesis : Lipid metabolism : Metabolism;Biotin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism Z1_01595 lpxD ko00540,ko01100,map00540,map01100 ko:K02536 2.3.1.191 Catalyzes the N-acylation of UDP-3-O- (hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01596 skp ko:K06142 Outer membrane protein (OmpH-like) NA Z1_01597 bamA ko:K07277 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery NA Z1_01598 rseP ko01503,ko02020,ko02024,ko04112,map01503,map02020,map02024,map04112 ko:K04771,ko:K11749 3.4.21.107 Peptidase family M50 Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases;Two-component system : Signal transduction : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Cell cycle - Caulobacter : Cell growth and death : Cellular Processes Z1_01599 cdsA ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 ko:K00981 2.7.7.41 Cytidylyltransferase family Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Phosphatidylinositol signaling system : Signal transduction : Environmental Information Processing Z1_01600 uppS ko00900,ko01110,map00900,map01110 ko:K00806 2.5.1.31 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide Terpenoid backbone biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_01601 dxr ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 ko:K00099 1.1.1.267 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) Terpenoid backbone biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA Z1_01602 frr ko:K02838 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another NA Z1_01603 pyrH ko00240,ko01100,map00240,map01100 ko:K09903 2.7.4.22 Catalyzes the reversible phosphorylation of UMP to UDP Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01604 tsf ko:K02357 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome NA Z1_01605 rpsB ko03010,map03010 ko:K02967 Ribosomal protein S2 Ribosome : Translation : Genetic Information Processing Z1_01606 map ko:K01265 3.4.11.18 Methionine aminopeptidase NA Z1_01607 glnD ko02020,map02020 ko:K00990 2.7.7.59 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen Two-component system : Signal transduction : Environmental Information Processing Z1_01610 yqcA ko:K06205 Flavodoxin NA Z1_01612 ptsG ko00010,ko00500,ko00520,ko02060,ko05111,map00010,map00500,map00520,map02060,map05111 ko:K02755,ko:K02756,ko:K02757,ko:K02778,ko:K02779,ko:K02790,ko:K02791,ko:K02802,ko:K02803,ko:K02804,ko:K02809,ko:K02810,ko:K02818,ko:K02819,ko:K20116,ko:K20117,ko:K20118 2.7.1.193,2.7.1.199,2.7.1.201,2.7.1.208,2.7.1.211 phosphotransferase system, EIIB Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes Z1_01613 truC ko:K06175 5.4.99.26 RNA pseudouridylate synthase NA Z1_01614 yqcC ko00521,ko00523,ko01130,map00521,map00523,map01130 ko:K01790,ko:K03806,ko:K06175 3.5.1.28,5.1.3.13,5.4.99.26 tRNA pseudouridine synthase C Streptomycin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Polyketide sugar unit biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;NA : NA : NA Z1_01615 syd ko:K15723 Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function NA Z1_01618 xni ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 ko:K01146,ko:K02335 2.7.7.7 Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;DNA replication : Replication and repair : Genetic Information Processing;Base excision repair : Replication and repair : Genetic Information Processing;Nucleotide excision repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing Z1_01621 gcvA ko02026,map02026 ko:K03566 Bacterial regulatory helix-turn-helix protein, lysR family Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes Z1_01622 csdA ko00450,ko01100,map00450,map01100 ko:K01766,ko:K11717 2.8.1.7,4.4.1.16 Aminotransferase class-V Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01623 csdE ko00450,ko01100,map00450,map01100 ko:K02426,ko:K07125,ko:K11717 2.8.1.7,4.4.1.16 cysteine desulfurase, sulfur acceptor subunit CsdE Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01624 ygdL ko00730,ko01100,ko04122,map00730,map01100,map04122 ko:K03148,ko:K21029,ko:K22132 2.7.7.73,2.7.7.80 ThiF family Thiamine metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing Z1_01625 mltA ko:K08304 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division NA Z1_01629 amiC ko01503,map01503 ko:K01448 3.5.1.28 N-acetylmuramoyl-L-alanine amidase Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases Z1_01630 argA ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 ko:K00619,ko:K00930,ko:K14682 2.3.1.1,2.7.2.8 Belongs to the acetyltransferase family. ArgA subfamily Arginine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_01631 recD ko03440,map03440 ko:K03581 3.1.11.5 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD Homologous recombination : Replication and repair : Genetic Information Processing Z1_01632 recB ko03440,map03440 ko:K03582,ko:K16898 3.1.11.5,3.6.4.12 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA Homologous recombination : Replication and repair : Genetic Information Processing Z1_01633 ptrA ko05010,map05010 ko:K01407,ko:K01408 3.4.24.55,3.4.24.56 Peptidase M16 inactive domain Alzheimer disease : Neurodegenerative disease : Human Diseases Z1_01634 recC ko03440,map03440 ko:K03583 3.1.11.5 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity Homologous recombination : Replication and repair : Genetic Information Processing Z1_01637 ppdB ko03070,ko05111,map03070,map05111 ko:K02459,ko:K02672,ko:K02680 prepilin peptidase dependent protein Bacterial secretion system : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes Z1_01638 ppdA ko:K02679,ko:K08084,ko:K08085 Prokaryotic N-terminal methylation motif NA Z1_01642 lgt ko:K03438,ko:K13292 2.1.1.199 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins NA Z1_01643 ptsP ko02060,map02060 ko:K08483,ko:K08484 2.7.3.9 phosphoenolpyruvate-protein phosphotransferase Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing Z1_01644 nudH ko03018,map03018 ko:K08311 Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage RNA degradation : Folding, sorting and degradation : Genetic Information Processing Z1_01645 tbpA ko02010,map02010 ko:K02064 Bacterial extracellular solute-binding protein ABC transporters : Membrane transport : Environmental Information Processing Z1_01646 thiP ko02010,map02010 ko:K02063 with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell ABC transporters : Membrane transport : Environmental Information Processing Z1_01647 thiQ ko02010,map02010 ko:K02062 Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system ABC transporters : Membrane transport : Environmental Information Processing Z1_01650 polB ko:K02336 2.7.7.7 DNA polymerase family B NA Z1_01651 rapA ko:K03580 Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair NA Z1_01652 rluA ko:K06177 5.4.99.28,5.4.99.29 Responsible for synthesis of pseudouridine from uracil NA Z1_01653 djlA ko:K05801 Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host NA Z1_01654 lptD ko:K04744 Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane NA Z1_01656 pdxA ko00750,ko01100,map00750,map01100 ko:K00097,ko:K22024 1.1.1.262,1.1.1.408,1.1.1.409 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) Vitamin B6 metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01657 ksgA ko:K02528 2.1.1.182 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits NA Z1_01658 apaG ko:K06195 ApaG domain NA Z1_01659 apaH ko00230,map00230 ko:K01525 3.6.1.41 Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP Purine metabolism : Nucleotide metabolism : Metabolism Z1_01660 folA ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523 ko:K00287 1.5.1.3 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Antifolate resistance : Drug resistance: antineoplastic : Human Diseases Z1_01663 ko:K12685,ko:K19231 Autotransporter beta-domain NA Z1_01665 plsC ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 ko:K00655,ko:K07003,ko:K15781 2.3.1.51,3.1.3.3 1-acyl-sn-glycerol-3-phosphate acyltransferase (1-AGP acyltransferase) (1-AGPAT) (lysophosphatidic acid acyltransferase) (LPAAT) K00655 Glycerolipid metabolism : Lipid metabolism : Metabolism;Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_01666 parC ko:K02469,ko:K02621 5.99.1.3 Belongs to the type II topoisomerase GyrA ParC subunit family NA Z1_01667 parE ko:K02470,ko:K02622 5.99.1.3 topoisomerase IV subunit B K02622 NA Z1_01668 yqiA ko:K07000 Uncharacterised protein family (UPF0227) NA Z1_01669 cpdA ko00230,ko00670,ko01100,ko01110,ko01130,ko02025,map00230,map00670,map01100,map01110,map01130,map02025 ko:K03651,ko:K11175 2.1.2.2,3.1.4.53 Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes Purine metabolism : Nucleotide metabolism : Metabolism;One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes Z1_01670 nudF ko00230,map00230 ko:K01515 3.6.1.13 NUDIX domain Purine metabolism : Nucleotide metabolism : Metabolism Z1_01673 ygiC ko00480,ko01100,map00480,map01100 ko:K01460 3.5.1.78,6.3.1.8 Glutathionylspermidine synthase preATP-grasp Glutathione metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01674 ygiD ko00362,ko00624,ko00627,ko00965,ko01120,map00362,map00624,map00627,map00965,map01120 ko:K04100,ko:K15777 1.13.11.8 Catalytic LigB subunit of aromatic ring-opening dioxygenase Benzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Polycyclic aromatic hydrocarbon degradation : Xenobiotics biodegradation and metabolism : Metabolism;Aminobenzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Betalain biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_01675 ribB ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 ko:K02858,ko:K14652 3.5.4.25,4.1.99.12 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate Riboflavin metabolism : Metabolism of cofactors and vitamins : Metabolism;Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_01676 yqiC ko:K09806 Membrane fusogenic activity NA Z1_01677 hldE ko00540,ko01100,map00540,map01100 ko:K03272,ko:K21344 2.7.1.167,2.7.7.70 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01678 glnE ko:K00982 2.7.7.42,2.7.7.89 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell NA Z1_01679 ygiF ko:K18446 3.6.1.25 CYTH domain NA Z1_01680 ygiM ko:K07184 sh3 domain protein NA Z1_01681 cca ko03013,ko03018,map03013,map03018 ko:K00970,ko:K00974 2.7.7.19,2.7.7.72 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases RNA transport : Translation : Genetic Information Processing;RNA degradation : Folding, sorting and degradation : Genetic Information Processing Z1_01682 folB ko00790,ko01100,map00790,map01100 ko:K01633 1.13.11.81,4.1.2.25,5.1.99.8 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01683 plsY ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 ko:K08591 2.3.1.15 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP Glycerolipid metabolism : Lipid metabolism : Metabolism;Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_01685 pheA ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 ko:K04518 4.2.1.51 Prephenate dehydratase Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_01687 aroH ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 ko:K01626 2.5.1.54 phospho-2-dehydro-3-deoxyheptonate aldolase Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism;Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_01688 tsaD ko02024,ko03060,ko03070,map02024,map03060,map03070 ko:K01409,ko:K03070 2.3.1.234 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Protein export : Folding, sorting and degradation : Genetic Information Processing;Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_01689 rpsU ko03010,map03010 ko:K02970 Belongs to the bacterial ribosomal protein bS21 family Ribosome : Translation : Genetic Information Processing Z1_01690 dnaG ko03030,map03030 ko:K02316 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication DNA replication : Replication and repair : Genetic Information Processing Z1_01691 rpoD ko:K03086 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth NA Z1_01695 ko:K08994 Membrane NA Z1_01697 cioB ko00190,ko01100,ko02020,map00190,map01100,map02020 ko:K00426 1.10.3.14 Cytochrome bd terminal oxidase subunit II Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing Z1_01701 tar ko02020,ko02030,map02020,map02030 ko:K03406,ko:K05874,ko:K05875,ko:K05877 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Two-component system : Signal transduction : Environmental Information Processing;Bacterial chemotaxis : Cell motility : Cellular Processes Z1_01702 tar ko02020,ko02030,map02020,map02030 ko:K03406,ko:K05874,ko:K05875,ko:K05877 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Two-component system : Signal transduction : Environmental Information Processing;Bacterial chemotaxis : Cell motility : Cellular Processes Z1_01703 cicA ko00260,ko00561,ko00564,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00561,map00564,map00680,map01100,map01110,map01120,map01130,map01200,map01230 ko:K00655,ko:K01079,ko:K18697 2.3.1.51,3.1.3.27,3.1.3.3 haloacid dehalogenase-like hydrolase Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Glycerolipid metabolism : Lipid metabolism : Metabolism;Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_01705 terD ko:K05795 TerD domain NA Z1_01706 terC ko:K05794 Integral membrane protein TerC family NA Z1_01707 terB ko:K05793,ko:K05795 Tellurite resistance protein TerB NA Z1_01708 terA ko00471,ko01100,map00471,map01100 ko:K01776,ko:K05792 5.1.1.3 TerD domain D-Glutamine and D-glutamate metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01709 terZ ko:K05791 TerD domain NA Z1_01711 apt ko00230,ko00240,ko01100,map00230,map00240,map01100 ko:K00759,ko:K00762 2.4.2.10,2.4.2.7 TRSP domain C terminus to PRTase_2 Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01712 ko00500,ko01100,map00500,map01100 ko:K01087 3.1.3.12 phosphatase activity Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01713 stiP ko03010,map03010 ko:K07590 PELOTA RNA binding domain Ribosome : Translation : Genetic Information Processing Z1_01714 ko02020,map02020 ko:K01644 4.1.3.34 C-C_Bond_Lyase of the TIM-Barrel fold Two-component system : Signal transduction : Environmental Information Processing Z1_01716 ko:K03832 Gram-negative bacterial TonB protein C-terminal NA Z1_01717 ko:K03574 3.6.1.55 NUDIX domain NA Z1_01719 nadK ko00760,ko01100,map00760,map01100 ko:K00858 2.7.1.23 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01720 tetR ko:K18476 Tetracyclin repressor, C-terminal all-alpha domain NA Z1_01721 tetA ko:K08151,ko:K08153 Sugar (and other) transporter NA Z1_01724 dhaK ko00051,ko00561,ko00680,ko01100,ko01120,ko01200,ko04622,map00051,map00561,map00680,map01100,map01120,map01200,map04622 ko:K00863,ko:K05878 2.7.1.121,2.7.1.28,2.7.1.29,4.6.1.15 dihydroxyacetone kinase Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Glycerolipid metabolism : Lipid metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism;RIG-I-like receptor signaling pathway : Immune system : Organismal Systems Z1_01726 dhaM ko00051,ko00561,ko01100,ko01120,ko02060,map00051,map00561,map01100,map01120,map02060 ko:K02768,ko:K02784,ko:K05881,ko:K08483,ko:K08485,ko:K11183,ko:K11189 2.7.1.121,2.7.1.202,2.7.3.9 PTS system fructose IIA component Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Glycerolipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing Z1_01729 pgtB ko02020,ko02030,map02020,map02030 ko:K02482,ko:K03406,ko:K07653,ko:K08475,ko:K10125 2.7.13.3 Signal transduction histidine kinase Two-component system : Signal transduction : Environmental Information Processing;Bacterial chemotaxis : Cell motility : Cellular Processes Z1_01730 pgtC ko02010,ko02020,map02010,map02020 ko:K02012,ko:K08478 Bacterial extracellular solute-binding protein ABC transporters : Membrane transport : Environmental Information Processing;Two-component system : Signal transduction : Environmental Information Processing Z1_01732 pyk ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 ko:K00873 2.7.1.40 Belongs to the pyruvate kinase family Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Purine metabolism : Nucleotide metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism;Glucagon signaling pathway : Endocrine system : Organismal Systems;Type II diabetes mellitus : Endocrine and metabolic disease : Human Diseases;Human papillomavirus infection : Infectious disease: viral : Human Diseases;Viral carcinogenesis : Cancer: overview : Human Diseases;Central carbon metabolism in cancer : Cancer: overview : Human Diseases Z1_01733 ybiI ko02026,map02026 ko:K06204 Prokaryotic dksA/traR C4-type zinc finger Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes Z1_01736 citN ko:K03300 Citrate transporter NA Z1_01737 citN ko:K03300 Citrate transporter NA Z1_01738 deoD ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,map00230,map00240,map00270,map00760,map01100,map01110 ko:K00772,ko:K03784 2.4.2.1,2.4.2.28 Phosphorylase superfamily Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_01739 deoB ko00030,ko00230,map00030,map00230 ko:K01839 5.4.2.7 Phosphotransfer between the C1 and C5 carbon atoms of pentose Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Purine metabolism : Nucleotide metabolism : Metabolism Z1_01740 deoA ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219 ko:K00756,ko:K00758 2.4.2.2,2.4.2.4 The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Drug metabolism - other enzymes : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Bladder cancer : Cancer: specific types : Human Diseases Z1_01741 deoC ko00030,map00030 ko:K01619 4.1.2.4 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate Pentose phosphate pathway : Carbohydrate metabolism : Metabolism Z1_01742 nupX ko:K03317 Na+ dependent nucleoside transporter C-terminus NA Z1_01743 yjjV ko:K03424 TatD related DNase NA Z1_01745 osmY ko:K04065 BON domain NA Z1_01746 prfC ko:K02837 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP NA Z1_01752 ko02020,ko02024,ko02026,ko02040,map02020,map02024,map02026,map02040 ko:K02403 Flagellar transcriptional activator (FlhD) Two-component system : Signal transduction : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Flagellar assembly : Cell motility : Cellular Processes Z1_01753 ko02020,ko02024,ko02026,ko02040,map02020,map02024,map02026,map02040 ko:K02402 Flagellar transcriptional activator (FlhC) Two-component system : Signal transduction : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Flagellar assembly : Cell motility : Cellular Processes Z1_01755 ko:K12056 PFAM TraG-like protein, N-terminal region NA Z1_01756 ko:K12072 Conjugative relaxosome accessory transposon protein NA Z1_01757 traF ko04621,ko05418,map04621,map05418 ko:K03671,ko:K12057 F plasmid transfer operon protein NOD-like receptor signaling pathway : Immune system : Organismal Systems;Fluid shear stress and atherosclerosis : Cardiovascular disease : Human Diseases Z1_01761 radC ko:K03630 RadC-like JAB domain NA Z1_01764 ko00010,ko00030,ko00051,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00500,map00520,map01100,map01110,map01120,map01130,map01200 ko:K15916 5.3.1.8,5.3.1.9 Protein of unknown function (DUF3150) Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism Z1_01766 cobS ko00860,ko01100,map00860,map01100 ko:K09882 6.6.1.2 AAA domain (dynein-related subfamily) Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01767 ko:K07464 3.1.12.1 YqaJ-like viral recombinase domain NA Z1_01770 ssb ko03030,ko03430,ko03440,map03030,map03430,map03440 ko:K03111 DNA-binding protein DNA replication : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing Z1_01773 fusA ko:K02355 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome NA Z1_01774 rpsG ko03010,map03010 ko:K02992 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA Ribosome : Translation : Genetic Information Processing Z1_01775 rpsL ko03010,map03010 ko:K02950 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit Ribosome : Translation : Genetic Information Processing Z1_01776 tusB ko04122,map04122 ko:K07237 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing Z1_01777 tusC ko04122,map04122 ko:K07236 DsrE/DsrF-like family Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing Z1_01778 tusD ko04122,map04122 ko:K07235 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing Z1_01781 fkpA ko:K03772 5.2.1.8 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase NA Z1_01782 slyX ko:K03745 SlyX NA Z1_01783 slyD ko:K03774,ko:K03775 5.2.1.8 FKBP-type peptidyl-prolyl cis-trans isomerase NA Z1_01784 yheV ko:K07070 Probable metal-binding protein (DUF2387) NA Z1_01785 kefB ko:K03455,ko:K11747 Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K( ) H( ) antiport NA Z1_01786 kefG ko:K03923,ko:K11748 Flavodoxin-like fold NA Z1_01788 tar ko02020,ko02030,map02020,map02030 ko:K03406,ko:K05874,ko:K05875,ko:K05877 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Two-component system : Signal transduction : Environmental Information Processing;Bacterial chemotaxis : Cell motility : Cellular Processes Z1_01789 tar ko02020,ko02030,map02020,map02030 ko:K03406,ko:K05874,ko:K05875,ko:K05877 chemotaxis, protein Two-component system : Signal transduction : Environmental Information Processing;Bacterial chemotaxis : Cell motility : Cellular Processes Z1_01792 ko02025,ko03070,map02025,map03070 ko:K06887,ko:K11903 VI_effect_Hcp1 type VI secretion system effector, Hcp1 family protein Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes;Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_01793 aer ko02020,ko02030,map02020,map02030 ko:K03406,ko:K03776 PAS fold Two-component system : Signal transduction : Environmental Information Processing;Bacterial chemotaxis : Cell motility : Cellular Processes Z1_01794 murR ko:K15835,ko:K19337 Helix-turn-helix domain, rpiR family NA Z1_01796 yheT ko:K07019 Serine aminopeptidase, S33 NA Z1_01797 yheU ko:K07019,ko:K09898 Uncharacterised protein family (UPF0270) NA Z1_01798 prkB ko00710,ko01100,ko01120,ko01200,map00710,map01100,map01120,map01200 ko:K00855 2.7.1.19 Phosphoribulokinase / Uridine kinase family Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism Z1_01799 yhfA ko:K07397 OsmC-like protein NA Z1_01800 crp ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 ko:K10914 Cyclic nucleotide-binding domain Two-component system : Signal transduction : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes Z1_01801 argD ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 ko:K00821 2.6.1.11,2.6.1.17 acetylornithine Arginine biosynthesis : Amino acid metabolism : Metabolism;Lysine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_01802 pabA ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 ko:K01658,ko:K01664 2.6.1.85,4.1.3.27 Peptidase C26 Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Phenazine biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes Z1_01803 ppiA ko01503,ko04217,map01503,map04217 ko:K03767,ko:K03768 5.2.1.8 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases;Necroptosis : Cell growth and death : Cellular Processes Z1_01804 engB ko:K03978 Necessary for normal cell division and for the maintenance of normal septation NA Z1_01805 def ko:K01462 3.5.1.88 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions NA Z1_01806 polA ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 ko:K01146,ko:K02335 2.7.7.7 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;DNA replication : Replication and repair : Genetic Information Processing;Base excision repair : Replication and repair : Genetic Information Processing;Nucleotide excision repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing Z1_01807 ko:K15383 Sugar efflux transporter for intercellular exchange NA Z1_01808 dsbA ko01503,map01503 ko:K03673 DSBA-like thioredoxin domain Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases Z1_01810 yihD ko:K09896 Protein of unknown function (DUF1040) NA Z1_01811 mobA ko00790,ko01100,map00790,map01100 ko:K03750,ko:K03752,ko:K13818 2.10.1.1,2.7.7.77 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01812 mobB ko00790,ko01100,map00790,map01100 ko:K02379,ko:K03750,ko:K03752,ko:K03753,ko:K13818 2.10.1.1,2.7.7.77 Molybdopterin guanine dinucleotide synthesis protein B Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01814 ko00260,ko01100,map00260,map01100 ko:K00303 1.5.3.1 NAD(P)-binding Rossmann-like domain Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01816 gor ko00480,ko04918,map00480,map04918 ko:K00383 1.8.1.7 Pyridine nucleotide-disulphide oxidoreductase Glutathione metabolism : Metabolism of other amino acids : Metabolism;Thyroid hormone synthesis : Endocrine system : Organismal Systems Z1_01817 rlmJ ko:K07115 2.1.1.266 Specifically methylates the adenine in position 2030 of 23S rRNA NA Z1_01819 yhjD ko:K07058 Virulence factor BrkB NA Z1_01820 dmpI ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220 ko:K01821 5.3.2.6 Tautomerase enzyme Benzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Dioxin degradation : Xenobiotics biodegradation and metabolism : Metabolism;Xylene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Degradation of aromatic compounds : Global and overview maps : Metabolism Z1_01822 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 ko:K02342 2.7.7.7 Gammaproteobacterial periplasmic sensor domain Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;DNA replication : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing Z1_01824 dppF ko01501,ko02010,ko02024,map01501,map02010,map02024 ko:K02032,ko:K10823,ko:K10824,ko:K12372 3.6.3.24 Belongs to the ABC transporter superfamily beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_01825 dppD ko01501,ko02010,ko02024,map01501,map02010,map02024 ko:K02031,ko:K02032,ko:K12371,ko:K15583,ko:K15587 3.6.3.24 Belongs to the ABC transporter superfamily beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_01826 dppC ko01501,ko02010,ko02024,map01501,map02010,map02024 ko:K02034,ko:K12370,ko:K15582,ko:K15586 N-terminal TM domain of oligopeptide transport permease C beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_01827 dppB ko02010,ko02024,map02010,map02024 ko:K02033,ko:K12369 Binding-protein-dependent transport system inner membrane component ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_01828 dppA ko02010,ko02024,ko02030,map02010,map02024,map02030 ko:K02035,ko:K12368 Bacterial extracellular solute-binding proteins, family 5 Middle ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Bacterial chemotaxis : Cell motility : Cellular Processes Z1_01829 ko03070,ko05133,map03070,map05133 ko:K07326,ko:K11017 POTRA domain Bacterial secretion system : Membrane transport : Environmental Information Processing;Pertussis : Infectious disease: bacterial : Human Diseases Z1_01833 yidE ko:K03281,ko:K07085 Predicted Permease Membrane Region NA Z1_01835 tag ko03410,map03410 ko:K01246 3.2.2.20 DNA-3-methyladenine glycosylase I (3-methyladenine-DNA glycosylase I, constitutive) (TAG I) (DNA-3-methyladenine glycosidase I) K01246 Base excision repair : Replication and repair : Genetic Information Processing Z1_01836 glyQ ko00970,map00970 ko:K01878,ko:K14164 6.1.1.14 Glycyl-tRNA synthetase alpha subunit Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing Z1_01837 glyS ko00970,map00970 ko:K01879,ko:K14164 6.1.1.14 Glycyl-tRNA synthetase beta subunit Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing Z1_01839 ko:K07726 helix-turn-helix NA Z1_01844 gmk ko00230,ko00240,ko01100,map00230,map00240,map01100 ko:K00942,ko:K01591 2.7.4.8,4.1.1.23 Essential for recycling GMP and indirectly, cGMP Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01845 rpoZ ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 ko:K03060 2.7.7.6 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;RNA polymerase : Transcription : Genetic Information Processing Z1_01846 spoT ko00230,map00230 ko:K00951,ko:K01139 2.7.6.5,3.1.7.2 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance Purine metabolism : Nucleotide metabolism : Metabolism Z1_01847 trmH ko:K00556,ko:K03214,ko:K03218,ko:K03437,ko:K15333 2.1.1.185,2.1.1.34 Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA NA Z1_01848 recG ko03440,map03440 ko:K03655 3.6.4.12 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) Homologous recombination : Replication and repair : Genetic Information Processing Z1_01851 yicH ko:K07289 AsmA Family NA Z1_01853 rluF ko:K06178,ko:K06182,ko:K06183 5.4.99.19,5.4.99.21,5.4.99.22 S4 RNA-binding domain NA Z1_01854 yiiD ko:K06323 Putative thioesterase (yiiD_Cterm) NA Z1_01855 dtd ko:K07560 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality NA Z1_01856 yihX ko00010,ko01120,map00010,map01120 ko:K20866 3.1.3.10 Haloacid dehalogenase-like hydrolase Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_01859 ko:K06182 5.4.99.21 RNA pseudouridylate synthase NA Z1_01863 glnL ko02020,map02020 ko:K07708,ko:K07710 2.7.13.3 Signal transduction histidine kinase, nitrogen specific Two-component system : Signal transduction : Environmental Information Processing Z1_01864 glnG ko02020,map02020 ko:K07712 Bacterial regulatory protein, Fis family Two-component system : Signal transduction : Environmental Information Processing Z1_01870 yhgF ko:K06959 Likely ribonuclease with RNase H fold. NA Z1_01871 greB ko:K04760 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length NA Z1_01874 pstS ko02010,ko02020,ko05152,map02010,map02020,map05152 ko:K02040 Part of the ABC transporter complex PstSACB involved in phosphate import ABC transporters : Membrane transport : Environmental Information Processing;Two-component system : Signal transduction : Environmental Information Processing;Tuberculosis : Infectious disease: bacterial : Human Diseases Z1_01875 pstC ko02010,map02010 ko:K02037,ko:K02038 probably responsible for the translocation of the substrate across the membrane ABC transporters : Membrane transport : Environmental Information Processing Z1_01877 pstB ko02010,map02010 ko:K02036 3.6.3.27 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system ABC transporters : Membrane transport : Environmental Information Processing Z1_01878 phoU ko:K02039 Part of the phosphate (Pho) regulon, which plays a key role in phosphate homeostasis. PhoU is essential for the repression of the Pho regulon at high phosphate conditions NA Z1_01879 fliY_2 ko:K02030 Bacterial periplasmic substrate-binding proteins NA Z1_01880 gltJ ko02010,ko02020,map02010,map02020 ko:K02029,ko:K10003,ko:K10040 Binding-protein-dependent transport system inner membrane component ABC transporters : Membrane transport : Environmental Information Processing;Two-component system : Signal transduction : Environmental Information Processing Z1_01881 glnP ko02010,ko02020,map02010,map02020 ko:K02029,ko:K10002 (ABC) transporter ABC transporters : Membrane transport : Environmental Information Processing;Two-component system : Signal transduction : Environmental Information Processing Z1_01883 fabD ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 ko:K00645,ko:K15327,ko:K15329,ko:K15355,ko:K15469 2.3.1.39 Acyl transferase domain Fatty acid biosynthesis : Lipid metabolism : Metabolism;Prodigiosin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;NA : NA : NA;Fatty acid metabolism : Global and overview maps : Metabolism Z1_01884 ko02010,ko02020,map02010,map02020 ko:K02003,ko:K02004,ko:K09808,ko:K11636 ABC-type transport system involved in lipoprotein release permease component ABC transporters : Membrane transport : Environmental Information Processing;Two-component system : Signal transduction : Environmental Information Processing Z1_01886 ybbA ko:K02003,ko:K02004 lipoprotein transporter activity NA Z1_01888 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 ko:K09458 2.3.1.179 Beta-ketoacyl synthase, C-terminal domain Fatty acid biosynthesis : Lipid metabolism : Metabolism;Biotin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism Z1_01890 gcvT ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 ko:K00605,ko:K11053 2.1.2.10 Glycine cleavage T-protein C-terminal barrel domain Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism Z1_01891 ko:K02078 acyl carrier protein NA Z1_01894 acpS ko00770,map00770 ko:K00997,ko:K17758 2.7.8.7,4.2.1.136 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism Z1_01896 yicO ko:K06901 Permease family NA Z1_01897 ko:K03790 2.3.1.128 Acetyltransferase (GNAT) domain NA Z1_01899 yihI ko:K09894 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis NA Z1_01901 feoA ko:K04758 ferrous iron import across plasma membrane NA Z1_01903 feoC ko:K07490 May function as a transcriptional regulator that controls feoABC expression NA Z1_01905 bioH ko00780,ko01100,map00780,map01100 ko:K02169,ko:K02170 2.1.1.197,3.1.1.85 The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters Biotin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01907 nfuA ko:K07400,ko:K13628,ko:K19168 Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins NA Z1_01908 glpE ko00920,ko01110,ko01120,map00920,map01110,map01120 ko:K02439,ko:K07390 2.8.1.1 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide Sulfur metabolism : Energy metabolism : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_01909 glpG ko:K02441 Rhomboid-type serine protease that catalyzes intramembrane proteolysis NA Z1_01910 glpR ko:K02444 DeoR C terminal sensor domain NA Z1_01911 glpD ko00564,ko01110,map00564,map01110 ko:K00111 1.1.5.3 C-terminal domain of alpha-glycerophosphate oxidase Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_01913 MTHFR1 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,ko03440,ko03460,map00670,map00720,map01100,map01120,map01200,map01523,map03440,map03460 ko:K00297,ko:K10901 1.5.1.20,3.6.4.12 methylenetetrahydrofolate reductase (NAD(P)H) activity One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism;Antifolate resistance : Drug resistance: antineoplastic : Human Diseases;Homologous recombination : Replication and repair : Genetic Information Processing;Fanconi anemia pathway : Replication and repair : Genetic Information Processing Z1_01915 fruR ko00052,ko00500,ko01100,map00052,map00500,map01100 ko:K01193,ko:K02529,ko:K03435 3.2.1.26 helix_turn _helix lactose operon repressor Galactose metabolism : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01916 ko02020,map02020 ko:K07793 Tripartite tricarboxylate transporter TctA family Two-component system : Signal transduction : Environmental Information Processing Z1_01919 ko:K05989 3.2.1.40 BNR repeat-like domain NA Z1_01920 ko00261,ko00300,ko00520,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map00520,map01100,map01110,map01120,map01130,map01230 ko:K01639,ko:K01714 4.1.3.3,4.3.3.7 Dihydrodipicolinate synthetase family Monobactam biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Lysine biosynthesis : Amino acid metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_01921 ko00051,ko01120,map00051,map01120 ko:K01818 5.3.1.25,5.3.1.3 Converts the aldose L-fucose into the corresponding ketose L-fuculose Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_01924 ko01501,ko02010,ko02024,map01501,map02010,map02024 ko:K10823,ko:K10824,ko:K12372 3.6.3.24 ATPases associated with a variety of cellular activities beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_01925 oppD ko01501,ko02010,ko02024,map01501,map02010,map02024 ko:K02031,ko:K02032,ko:K12371,ko:K15583,ko:K15587 3.6.3.24 ATPases associated with a variety of cellular activities beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_01926 ko01501,ko02010,ko02024,map01501,map02010,map02024 ko:K02034,ko:K12370,ko:K15582,ko:K15586 N-terminal TM domain of oligopeptide transport permease C beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_01927 nikB ko02010,map02010 ko:K15585 Binding-protein-dependent transport system inner membrane component ABC transporters : Membrane transport : Environmental Information Processing Z1_01928 nikA ko02010,map02010 ko:K15584 Bacterial extracellular solute-binding proteins, family 5 Middle ABC transporters : Membrane transport : Environmental Information Processing Z1_01930 mtsE ko05322,map05322 ko:K11089 von willebrand factor, type A Systemic lupus erythematosus : Immune disease : Human Diseases Z1_01931 ko:K16078 Enterobacterial Ail/Lom protein NA Z1_01932 chbG ko00500,ko02060,map00500,map02060 ko:K02759,ko:K03478 2.7.1.196,2.7.1.205,3.5.1.105 Involved in the degradation of chitin. ChbG is essential for growth on the acetylated chitooligosaccharides chitobiose and chitotriose but is dispensable for growth on cellobiose and chitosan dimer, the deacetylated form of chitobiose. Deacetylation of chitobiose-6-P and chitotriose-6-P is necessary for both the activation of the chb promoter by the regulatory protein ChbR and the hydrolysis of phosphorylated beta-glucosides by the phospho- beta-glucosidase ChbF. Catalyzes the removal of only one acetyl group from chitobiose-6-P to yield monoacetylchitobiose-6-P, the inducer of ChbR and the substrate of ChbF Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing Z1_01934 chbR ko03410,map03410 ko:K01174,ko:K03490,ko:K10778,ko:K13529,ko:K15051 2.1.1.63,3.1.31.1,3.2.2.21 helix_turn_helix, arabinose operon control protein Base excision repair : Replication and repair : Genetic Information Processing Z1_01935 celC ko00500,ko02060,map00500,map02060 ko:K02759 2.7.1.196,2.7.1.205 PTS system, Lactose/Cellobiose specific IIA subunit Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing Z1_01936 celB ko00500,ko02060,map00500,map02060 ko:K02761 The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing Z1_01937 chbB ko00500,ko02060,map00500,map02060 ko:K02760 2.7.1.196,2.7.1.205 PTS system, Lactose/Cellobiose specific IIB subunit Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing Z1_01938 fatB ko02010,map02010 ko:K02016 Periplasmic binding protein ABC transporters : Membrane transport : Environmental Information Processing Z1_01939 feuB ko02010,map02010 ko:K02015 FecCD transport family ABC transporters : Membrane transport : Environmental Information Processing Z1_01940 fatC ko02010,map02010 ko:K02015 FecCD transport family ABC transporters : Membrane transport : Environmental Information Processing Z1_01943 smvA ko:K08167 Major facilitator superfamily NA Z1_01945 dmsA ko00920,map00920 ko:K07306 1.8.5.3 anaerobic DMSO reductase chain A precursor K00369 Sulfur metabolism : Energy metabolism : Metabolism Z1_01946 ko00920,map00920 ko:K07307 4Fe-4S binding domain Sulfur metabolism : Energy metabolism : Metabolism Z1_01947 ko00920,map00920 ko:K07308 DMSO reductase anchor subunit (DmsC) Sulfur metabolism : Energy metabolism : Metabolism Z1_01948 ko:K02027,ko:K02529 Bacterial extracellular solute-binding protein NA Z1_01949 ko00440,map00440 ko:K06167 3.1.4.55 Beta-lactamase superfamily domain Phosphonate and phosphinate metabolism : Metabolism of other amino acids : Metabolism Z1_01950 ko01501,map01501 ko:K03301,ko:K08218,ko:K11537 Nucleoside H+ symporter beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases Z1_01951 sapB ko:K07507 MgtC family NA Z1_01954 nanA ko00261,ko00300,ko00520,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map00520,map01100,map01110,map01120,map01130,map01230 ko:K01639,ko:K01714 4.1.3.3,4.3.3.7 Dihydrodipicolinate synthetase family Monobactam biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Lysine biosynthesis : Amino acid metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_01955 rpiR ko:K15835,ko:K19337 Helix-turn-helix domain, rpiR family NA Z1_01956 yhcH ko:K19334 Domain of unknown function (DUF386) NA Z1_01957 nanT ko:K03307 Sodium:solute symporter family NA Z1_01958 nanK ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 ko:K00845,ko:K00885,ko:K13967 2.7.1.2,2.7.1.60,5.1.3.9 ROK family Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Streptomycin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Neomycin, kanamycin and gentamicin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism Z1_01959 nanE ko00520,ko01100,map00520,map01100 ko:K01788,ko:K13967 2.7.1.60,5.1.3.9 Putative N-acetylmannosamine-6-phosphate epimerase Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01960 fdhF ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200 ko:K00123,ko:K05299,ko:K22015 1.17.1.10,1.17.1.9,1.17.99.7 Molybdopterin oxidoreductase Fe4S4 domain Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism Z1_01961 ko:K03308 Sodium:neurotransmitter symporter family NA Z1_01962 ko00230,ko00250,ko00362,ko01100,ko01110,ko01120,ko01130,ko01220,map00230,map00250,map00362,map01100,map01110,map01120,map01130,map01220 ko:K01756,ko:K01857 4.3.2.2,5.5.1.2 3-carboxy-cis,cis-muconate cycloisomerase Purine metabolism : Nucleotide metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Benzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Degradation of aromatic compounds : Global and overview maps : Metabolism Z1_01963 malX ko00010,ko00500,ko00520,ko02060,ko05111,map00010,map00500,map00520,map02060,map05111 ko:K02755,ko:K02756,ko:K02757,ko:K02778,ko:K02779,ko:K02790,ko:K02791,ko:K02802,ko:K02803,ko:K02804,ko:K02809,ko:K02810,ko:K02818,ko:K02819 2.7.1.193,2.7.1.199,2.7.1.201,2.7.1.208,2.7.1.211 phosphotransferase system, EIIB Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes Z1_01964 glvR ko:K15835,ko:K19337 Helix-turn-helix domain, rpiR family NA Z1_01965 csp ko:K03704 'Cold-shock' DNA-binding domain NA Z1_01966 rluA ko:K06177 5.4.99.28,5.4.99.29 RNA pseudouridylate synthase NA Z1_01967 yaiL ko:K09912 Uncharacterized protein conserved in bacteria (DUF2058) NA Z1_01969 ruvB ko03440,map03440 ko:K03551 3.6.4.12 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing Homologous recombination : Replication and repair : Genetic Information Processing Z1_01970 ruvA ko03440,map03440 ko:K03550 3.6.4.12 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB Homologous recombination : Replication and repair : Genetic Information Processing Z1_01971 ruvC ko03440,map03440 ko:K01159 3.1.22.4 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group Homologous recombination : Replication and repair : Genetic Information Processing Z1_01973 nudB ko00230,ko00785,ko00790,ko01100,map00230,map00785,map00790,map01100 ko:K01515,ko:K03574,ko:K03801,ko:K08310 2.3.1.181,3.6.1.13,3.6.1.55,3.6.1.67 NUDIX domain Purine metabolism : Nucleotide metabolism : Metabolism;Lipoic acid metabolism : Metabolism of cofactors and vitamins : Metabolism;Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01974 aspS ko00970,map00970 ko:K01876 6.1.1.12 Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing Z1_01975 yecN ko:K07136 MAPEG family NA Z1_01977 cmoB ko:K15257 Catalyzes carboxymethyl transfer from carboxy-S- adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs NA Z1_01981 cutC ko:K06201 Participates in the control of copper homeostasis NA Z1_01982 yecM ko:K09907 YecM protein NA Z1_01983 argS ko00970,map00970 ko:K01887 6.1.1.19 Arginyl tRNA synthetase N terminal dom Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing Z1_01985 murJ ko:K03980 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane NA Z1_01986 rimJ ko:K03790 2.3.1.128 Acetyltransferase (GNAT) domain NA Z1_01987 mdtH ko:K06610,ko:K08162 Major Facilitator Superfamily NA Z1_01990 ko:K07394 2OG-Fe(II) oxygenase NA Z1_01992 ghrA ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00260,map00620,map00630,map01100,map01110,map01120 ko:K12972 1.1.1.79,1.1.1.81 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_01994 sulP ko:K03321 Sulfate permease family NA Z1_01996 yhcC ko:K07139 Radical_SAM C-terminal domain NA Z1_01997 kdsA ko00540,ko01100,map00540,map01100 ko:K01627 2.5.1.55 DAHP synthetase I family Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_01999 prmC ko:K02493,ko:K02835,ko:K07320 2.1.1.297,2.1.1.298 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif NA Z1_02000 prfA ko:K02835,ko:K15034 peptide chain release factor NA Z1_02001 hemA ko00860,ko01100,ko01110,ko01120,ko02040,map00860,map01100,map01110,map01120,map02040 ko:K02407,ko:K02492 1.2.1.70 glutamyl-tRNA reductase Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Flagellar assembly : Cell motility : Cellular Processes Z1_02002 lolB ko:K02494 Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein NA Z1_02003 ispE ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 ko:K00919,ko:K02528,ko:K16924 2.1.1.182,2.7.1.148 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol Terpenoid backbone biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA Z1_02004 prs ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 ko:K00948 2.7.6.1 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Purine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_02006 pth ko:K01056 3.1.1.29 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis NA Z1_02007 ychF ko:K06942 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner NA Z1_02014 ko:K07346,ko:K12519 Pili assembly chaperone PapD, C-terminal domain NA Z1_02016 ko05133,map05133 ko:K07345 Fimbrial protein Pertussis : Infectious disease: bacterial : Human Diseases Z1_02017 ko02024,map02024 ko:K20374 Helix-turn-helix domain Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_02018 budA ko00650,ko00660,map00650,map00660 ko:K01575 4.1.1.5 Alpha-acetolactate decarboxylase Butanoate metabolism : Carbohydrate metabolism : Metabolism;C5-Branched dibasic acid metabolism : Carbohydrate metabolism : Metabolism Z1_02019 alsS ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 ko:K01652 2.2.1.6 Belongs to the TPP enzyme family Valine, leucine and isoleucine biosynthesis : Amino acid metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;C5-Branched dibasic acid metabolism : Carbohydrate metabolism : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_02020 ko:K03975 SNARE associated Golgi protein NA Z1_02021 ko:K07080 NMT1-like family NA Z1_02023 ko:K05799 FadR C-terminal domain NA Z1_02024 lhgO ko00650,map00650 ko:K00109,ko:K15736 1.1.99.2 FAD dependent oxidoreductase Butanoate metabolism : Carbohydrate metabolism : Metabolism Z1_02025 pqrA ko:K05804,ko:K13652,ko:K13653 helix_turn_helix, arabinose operon control protein NA Z1_02026 lplA ko00785,ko01100,map00785,map01100 ko:K03800 6.3.1.20 Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes Lipoic acid metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02027 nlpC ko:K13694,ko:K13695 3.4.17.13 NlpC/P60 family NA Z1_02028 arnF ko01503,map01503 ko:K12962,ko:K12963 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases Z1_02029 arnE ko01503,map01503 ko:K03297,ko:K12962,ko:K12963 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases Z1_02030 arnT ko01503,map01503 ko:K07264 2.4.2.43 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases Z1_02031 arnD ko00520,ko01503,map00520,map01503 ko:K13014 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases Z1_02032 arnA ko00052,ko00520,ko00523,ko00670,ko00970,ko01100,ko01130,ko01503,map00052,map00520,map00523,map00670,map00970,map01100,map01130,map01503 ko:K00604,ko:K01784,ko:K10011,ko:K12449,ko:K21332 1.1.1.305,2.1.2.13,2.1.2.9,5.1.3.2 Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides Galactose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Polyketide sugar unit biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing;Metabolic pathways : Global and overview maps : Metabolism;NA : NA : NA;Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases Z1_02033 arnC ko00520,ko01503,map00520,map01503 ko:K10012 2.4.2.53 Catalyzes the transfer of 4-deoxy-4-formamido-L- arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases Z1_02034 arnB ko00520,ko01503,ko02020,map00520,map01503,map02020 ko:K07806 2.6.1.87 Catalyzes the conversion of UDP-4-keto-arabinose (UDP- Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases;Two-component system : Signal transduction : Environmental Information Processing Z1_02035 btuD ko02010,map02010 ko:K06074 3.6.3.33 ATPases associated with a variety of cellular activities ABC transporters : Membrane transport : Environmental Information Processing Z1_02036 btuC ko02010,map02010 ko:K06073 FecCD transport family ABC transporters : Membrane transport : Environmental Information Processing Z1_02037 himA ko:K04764 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control NA Z1_02038 pheT ko00970,map00970 ko:K01890 6.1.1.20 B3/4 domain Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing Z1_02039 pheS ko00970,map00970 ko:K01889 6.1.1.20 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing Z1_02040 rplT ko03010,map03010 ko:K02887 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit Ribosome : Translation : Genetic Information Processing Z1_02041 rpmI ko03010,map03010 ko:K02916 Ribosomal protein L35 Ribosome : Translation : Genetic Information Processing Z1_02042 infC ko:K02520 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins NA Z1_02043 thrS ko00970,map00970 ko:K01868 6.1.1.3 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing Z1_02044 ydeQ ko:K07350 cell adhesion NA Z1_02045 ko:K02529 transcriptional regulator NA Z1_02046 csaA ko00450,ko00970,map00450,map00970 ko:K01874,ko:K01890,ko:K04566,ko:K06878 6.1.1.10,6.1.1.20,6.1.1.6 Putative tRNA binding domain Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing Z1_02048 marC ko:K05595 MarC family integral membrane protein NA Z1_02049 emtA ko:K08306,ko:K08308,ko:K08309 Transglycosylase SLT domain NA Z1_02050 sitA ko02010,ko02020,map02010,map02020 ko:K09818,ko:K11601,ko:K11604,ko:K11704,ko:K19971,ko:K19975,ko:K19976 Zinc-uptake complex component A periplasmic ABC transporters : Membrane transport : Environmental Information Processing;Two-component system : Signal transduction : Environmental Information Processing Z1_02052 sitC ko02010,ko02020,map02010,map02020 ko:K11602,ko:K11605,ko:K11606 ABC 3 transport family ABC transporters : Membrane transport : Environmental Information Processing;Two-component system : Signal transduction : Environmental Information Processing Z1_02053 sitD ko02010,ko02020,map02010,map02020 ko:K11602,ko:K11606 ABC 3 transport family ABC transporters : Membrane transport : Environmental Information Processing;Two-component system : Signal transduction : Environmental Information Processing Z1_02056 yniC ko:K19270 3.1.3.23 Haloacid dehalogenase-like hydrolase NA Z1_02057 ydjM ko:K07038 LexA-binding, inner membrane-associated putative hydrolase NA Z1_02058 ydjN ko:K06956 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family NA Z1_02059 htpX ko:K03799 Peptidase family M48 NA Z1_02061 prc ko:K03797 3.4.21.102 tail-specific protease precursor (protease RE) (PRC protein) K03797 NA Z1_02062 proQ ko:K03607 RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities. May regulate ProP activity through an RNA-based, post-transcriptional mechanism NA Z1_02063 yebR ko00270,map00270 ko:K08968 1.8.4.14 Domain present in phytochromes and cGMP-specific phosphodiesterases. Cysteine and methionine metabolism : Amino acid metabolism : Metabolism Z1_02064 yebS ko:K03808 Paraquat-inducible protein A NA Z1_02065 yebT ko:K06192 MlaD protein NA Z1_02068 yebZ ko:K07245 copper resistance protein NA Z1_02069 yobA ko:K07156 CopC domain NA Z1_02070 ftnA ko:K02217 1.16.3.2 Iron-storage protein NA Z1_02071 uspF ko:K11932,ko:K14061 Universal stress protein family NA Z1_02073 cyaB ko00230,map00230 ko:K05873 4.6.1.1 CYTH domain Purine metabolism : Nucleotide metabolism : Metabolism Z1_02074 ycdX ko:K04477 DNA polymerase alpha chain like domain NA Z1_02075 hicB ko:K18843 HicB_like antitoxin of bacterial toxin-antitoxin system NA Z1_02076 lip ko00561,ko01100,map00561,map01100 ko:K01046 3.1.1.3 Alpha beta hydrolase Glycerolipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02078 map ko:K01265 3.4.11.18 Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) NA Z1_02084 ko:K09794 Protein of unknown function (DUF465) NA Z1_02091 ibrB ko:K03497 ParB-like nuclease domain NA Z1_02094 ko00240,ko00630,ko00983,ko01100,ko01110,ko01130,map00240,map00630,map00983,map01100,map01110,map01130 ko:K00876,ko:K01091 2.7.1.48,3.1.3.18 uridine kinase Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Drug metabolism - other enzymes : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA Z1_02096 ytfG ko00130,ko01110,map00130,map01110 ko:K19267 1.6.5.2 NmrA family Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_02099 ibp ko04141,map04141 ko:K04080,ko:K13993 Hsp20/alpha crystallin family Protein processing in endoplasmic reticulum : Folding, sorting and degradation : Genetic Information Processing Z1_02100 cspA ko:K03704 Cold shock protein domain NA Z1_02103 ko:K07483,ko:K07497 Transposase NA Z1_02111 prtS ko:K01361 3.4.21.96 YadA-like membrane anchor domain NA Z1_02113 osmY ko:K04065 BON domain NA Z1_02129 ko:K06904 Caudovirus prohead serine protease NA Z1_02133 ko:K07451 HNH nucleases NA Z1_02136 ko:K14744 Bacteriophage Rz lysis protein NA Z1_02138 rrrD ko:K01185 3.2.1.17 Lysozyme NA Z1_02142 yagU ko:K08996 Protein of unknown function (DUF1440) NA Z1_02146 murI ko00471,ko01100,map00471,map01100 ko:K01776 5.1.1.3 Provides the (R)-glutamate required for cell wall biosynthesis D-Glutamine and D-glutamate metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02147 btuB ko:K16092 Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB NA Z1_02149 trmA ko:K00557,ko:K03215 2.1.1.190,2.1.1.35 Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA) NA Z1_02151 fabR ko:K22105 Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer NA Z1_02153 oxyR ko02026,map02026 ko:K04761 Bacterial regulatory helix-turn-helix protein, lysR family Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes Z1_02155 argG ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 ko:K01940 6.3.4.5 Belongs to the argininosuccinate synthase family. Type 1 subfamily Arginine biosynthesis : Amino acid metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism;Fluid shear stress and atherosclerosis : Cardiovascular disease : Human Diseases Z1_02156 argB ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 ko:K00930,ko:K14682 2.3.1.1,2.7.2.8 Catalyzes the ATP-dependent phosphorylation of N-acetyl- L-glutamate Arginine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_02157 argC ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 ko:K00145 1.2.1.38 N-acetyl-glutamate semialdehyde dehydrogenase Arginine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_02158 argE ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 ko:K01438 3.5.1.16 Belongs to the peptidase M20A family. ArgE subfamily Arginine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_02159 poxB ko00620,ko01100,map00620,map01100 ko:K00156,ko:K00158 1.2.3.3,1.2.5.1 Belongs to the TPP enzyme family Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02162 yxeP ko:K12940 Peptidase dimerisation domain NA Z1_02163 cysB ko:K13634 LysR substrate binding domain NA Z1_02164 proP ko:K03762 Osmosensory transporter coiled coil NA Z1_02165 phrB ko:K01669 4.1.99.3 Belongs to the DNA photolyase family NA Z1_02167 ppc ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 ko:K01595 4.1.1.31 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism Z1_02169 yqhA ko:K03535 Uncharacterized protein family, UPF0114 NA Z1_02170 metL ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 ko:K00003,ko:K00928,ko:K12524,ko:K12525 1.1.1.3,2.7.2.4 Homoserine dehydrogenase Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Monobactam biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Lysine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_02172 metJ ko:K03764 This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis NA Z1_02173 yjjJ ko:K07154 2.7.11.1 HipA domain protein NA Z1_02174 rpmE ko03010,map03010 ko:K02909 Binds the 23S rRNA Ribosome : Translation : Genetic Information Processing Z1_02175 priA ko03440,map03440 ko:K04066 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA Homologous recombination : Replication and repair : Genetic Information Processing Z1_02176 cytR ko:K05499 Periplasmic binding protein-like domain NA Z1_02177 ftsN ko:K03591 Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases NA Z1_02178 hslV ko:K01419 3.4.25.2 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery NA Z1_02179 hslU ko:K03667 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis NA Z1_02180 menA ko00130,ko01100,ko01110,map00130,map01100,map01110 ko:K02548 2.5.1.74 1,4-dihydroxy-2-naphthoate octaprenyltransferase Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_02181 rraA ko:K02553 Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome NA Z1_02182 zapB ko02020,ko02030,map02020,map02030 ko:K09892,ko:K13924 2.1.1.80,3.1.1.61 Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA Two-component system : Signal transduction : Environmental Information Processing;Bacterial chemotaxis : Cell motility : Cellular Processes Z1_02183 glpF ko:K02440 Major intrinsic protein NA Z1_02184 glpK ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 ko:K00864 2.7.1.30 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate Glycerolipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;PPAR signaling pathway : Endocrine system : Organismal Systems;Plant-pathogen interaction : Environmental adaptation : Organismal Systems Z1_02185 emrD ko:K08154 Multidrug resistance protein D NA Z1_02186 fpr ko00362,ko00364,ko00622,ko01100,ko01120,ko01220,map00362,map00364,map00622,map01100,map01120,map01220 ko:K00528,ko:K05784 1.18.1.2,1.19.1.1 COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Benzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Fluorobenzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Xylene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Degradation of aromatic compounds : Global and overview maps : Metabolism Z1_02190 sbp ko00920,ko02010,map00920,map02010 ko:K02048 Bacterial extracellular solute-binding protein Sulfur metabolism : Energy metabolism : Metabolism;ABC transporters : Membrane transport : Environmental Information Processing Z1_02194 waaB ko00540,ko01100,map00540,map01100 ko:K02840 lipopolysaccharide-1,6-galactosyltransferase activity Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02195 cpxP ko:K06006 Heavy-metal resistance NA Z1_02198 vioA ko00523,ko01130,map00523,map01130 ko:K13308,ko:K20429 2.6.1.33 DegT/DnrJ/EryC1/StrS aminotransferase family Polyketide sugar unit biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;NA : NA : NA Z1_02201 ko00520,ko00523,ko01130,map00520,map00523,map01130 ko:K13010,ko:K13327 1.1.1.384,2.6.1.102 UDP-4-amino-4-deoxy-L-arabinose aminotransferase Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Polyketide sugar unit biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;NA : NA : NA Z1_02202 ko00052,ko00520,ko01100,map00052,map00520,map01100 ko:K01784 5.1.3.2 GDP-mannose 4,6 dehydratase Galactose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02203 ko00052,ko00520,ko01100,map00052,map00520,map01100 ko:K01784 5.1.3.2 GDP-mannose 4,6 dehydratase Galactose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02204 tagD ko00440,ko00564,ko01100,ko05231,map00440,map00564,map01100,map05231 ko:K00968,ko:K00980 2.7.7.15,2.7.7.39 cytidylyltransferase Phosphonate and phosphinate metabolism : Metabolism of other amino acids : Metabolism;Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Choline metabolism in cancer : Cancer: overview : Human Diseases Z1_02205 rfbX ko:K03328,ko:K18799 Polysaccharide biosynthesis protein NA Z1_02206 ko04614,ko04924,ko05142,ko05410,map04614,map04924,map05142,map05410 ko:K01283,ko:K09809 2.7.8.12,3.4.15.1 PFAM CDP-glycerol poly(glycerophosphate) glycerophosphotransferase Renin-angiotensin system : Endocrine system : Organismal Systems;Renin secretion : Endocrine system : Organismal Systems;Chagas disease : Infectious disease: parasitic : Human Diseases;Hypertrophic cardiomyopathy : Cardiovascular disease : Human Diseases Z1_02209 pglH ko05111,map05111 ko:K05946,ko:K16701,ko:K17249 2.4.1.187,2.4.1.292 Glycosyl transferases group 1 Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes Z1_02210 amsE ko:K16702 Glycosyltransferases involved in cell wall biogenesis NA Z1_02211 gne ko:K19997 5.1.3.26 NAD(P)H-binding NA Z1_02212 ugd ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 ko:K00012 1.1.1.22 UDP binding domain Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Ascorbate and aldarate metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02213 trmL ko:K03216 2.1.1.207 Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide NA Z1_02218 secB ko02024,ko03060,ko03070,map02024,map03060,map03070 ko:K03071 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Protein export : Folding, sorting and degradation : Genetic Information Processing;Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_02219 yibN ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 ko:K01011 2.8.1.1,2.8.1.2 Rhodanese Homology Domain Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing Z1_02222 envC ko:K06194,ko:K21471 Peptidase family M23 NA Z1_02223 yibQ ko:K09798 Divergent polysaccharide deacetylase NA Z1_02224 tdh ko00260,map00260 ko:K00060 1.1.1.103 Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism Z1_02225 kbl ko00260,ko00780,ko01100,map00260,map00780,map01100 ko:K00639,ko:K00652 2.3.1.29,2.3.1.47 Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Biotin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02226 hldD ko00540,ko01100,map00540,map01100 ko:K03274 5.1.3.20 Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02227 rfaF ko00540,ko01100,map00540,map01100 ko:K02843 Glycosyltransferase family 9 (heptosyltransferase) Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02228 rfaC ko00540,ko01100,map00540,map01100 ko:K02841 Glycosyltransferase family 9 (heptosyltransferase) Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02229 waaQ ko00540,ko01100,map00540,map01100 ko:K02841,ko:K02843,ko:K02849 Glycosyl transferase Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02231 rfaQ ko00540,ko01100,map00540,map01100 ko:K02849 Glycosyltransferase family 9 (heptosyltransferase) Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02232 rfaG ko00540,ko01100,map00540,map01100 ko:K02844 Catalyzes the addition of the first glucose residue to the LPS core Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02233 rfaB ko:K17248 2.4.1.291 Glycosyltransferase Family 4 NA Z1_02234 kdtA ko00540,ko01100,map00540,map01100 ko:K02527 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02235 waaE ko:K12984 Glycosyl transferase family 2 NA Z1_02236 coaD ko00770,ko01100,map00770,map01100 ko:K00954 2.7.7.3 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02237 fpg ko03410,map03410 ko:K10563 3.2.2.23,4.2.99.18 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates Base excision repair : Replication and repair : Genetic Information Processing Z1_02238 rfaL ko00540,ko01100,map00540,map01100 ko:K02847,ko:K16567 O-antigen ligase Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02241 ko00540,ko01100,map00540,map01100 ko:K02849 Glycosyltransferase family 9 (heptosyltransferase) Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02242 walR ko:K00754 glycosyl transferase group 1 NA Z1_02243 rpmG ko03010,map03010 ko:K02913 Ribosomal protein L33 Ribosome : Translation : Genetic Information Processing Z1_02244 rpmB ko03010,map03010 ko:K02902 Ribosomal L28 family Ribosome : Translation : Genetic Information Processing Z1_02245 radC ko:K03630 RadC-like JAB domain NA Z1_02246 coaBC ko00770,ko01100,map00770,map01100 ko:K01598,ko:K13038 4.1.1.36,6.3.2.5 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02247 dut ko00240,ko00770,ko00983,ko01100,map00240,map00770,map00983,map01100 ko:K01520,ko:K13038 3.6.1.23,4.1.1.36,6.3.2.5 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Drug metabolism - other enzymes : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02248 slmA ko:K05501 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions NA Z1_02249 pyrE ko00240,ko01100,map00240,map01100 ko:K00762 2.4.2.10 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02250 rph ko00230,map00230 ko:K00989,ko:K02428 2.7.7.56,3.6.1.66 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates Purine metabolism : Nucleotide metabolism : Metabolism Z1_02252 ko:K19165 Antitoxin component of a toxin-antitoxin (TA) module NA Z1_02253 doc ko:K07341 Death ON curing protein NA Z1_02254 ko02024,map02024 ko:K20391 Cro/C1-type HTH DNA-binding domain Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_02255 ko:K07154 2.7.11.1 Pfam:HipA_N NA Z1_02256 murQ ko00520,ko01100,map00520,map01100 ko:K07106 4.2.1.126 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02257 ko:K07126 Sel1-like repeats. NA Z1_02262 gyrB ko:K02470 5.99.1.3 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner NA Z1_02263 recF ko03440,map03440 ko:K03629 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP Homologous recombination : Replication and repair : Genetic Information Processing Z1_02264 dnaN ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 ko:K02338 2.7.7.7 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;DNA replication : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing Z1_02265 dnaA ko02020,ko04112,map02020,map04112 ko:K02313 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids Two-component system : Signal transduction : Environmental Information Processing;Cell cycle - Caulobacter : Cell growth and death : Cellular Processes Z1_02266 rpmH ko03010,map03010 ko:K02914 Ribosomal protein L34 Ribosome : Translation : Genetic Information Processing Z1_02267 rnpA ko:K03536,ko:K08998 3.1.26.5 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme NA Z1_02268 yidD ko:K08998 Haemolytic domain NA Z1_02270 ko:K03650 Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. TrmE GTPase family NA Z1_02273 repA ko:K08282 2.7.11.1 Plasmid encoded RepA protein NA Z1_02275 traN ko:K12058 Type-1V conjugative transfer system mating pair stabilisation NA Z1_02276 ko02020,ko02024,ko02026,ko02040,map02020,map02024,map02026,map02040 ko:K02402 Flagellar transcriptional activator (FlhC) Two-component system : Signal transduction : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Flagellar assembly : Cell motility : Cellular Processes Z1_02281 ko:K12056 PFAM TraG-like protein, N-terminal region NA Z1_02282 ko:K12072 Conjugative relaxosome accessory transposon protein NA Z1_02289 ko:K04763 Integrase NA Z1_02291 ko:K07459 ATP-dependent endonuclease of the OLD family NA Z1_02295 groL ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 ko:K04077 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions RNA degradation : Folding, sorting and degradation : Genetic Information Processing;Longevity regulating pathway - worm : Aging : Organismal Systems;Type I diabetes mellitus : Endocrine and metabolic disease : Human Diseases;Legionellosis : Infectious disease: bacterial : Human Diseases;Tuberculosis : Infectious disease: bacterial : Human Diseases Z1_02296 groS ko:K04078 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter NA Z1_02297 fxsA ko:K07113 FxsA cytoplasmic membrane protein NA Z1_02298 aspA ko00250,ko01100,map00250,map01100 ko:K01744 4.3.1.1 Lyase Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02299 dcuA ko02020,map02020 ko:K07791,ko:K07792 Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane Two-component system : Signal transduction : Environmental Information Processing Z1_02303 ko:K06872 TPM domain NA Z1_02304 lemA ko:K03744 LemA protein NA Z1_02306 yqiK ko04910,map04910 ko:K07192 protein conserved in bacteria Insulin signaling pathway : Endocrine system : Organismal Systems Z1_02307 ko:K03924 ATPase involved in DNA repair NA Z1_02308 ygcS ko:K08368 Sugar (and other) transporter NA Z1_02309 fixX ko:K03855 ferredoxin-like protein NA Z1_02311 fixB ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 ko:K00248,ko:K03522 1.3.8.1 Required for anaerobic carnitine reduction. May bring reductant to CaiA Fatty acid degradation : Lipid metabolism : Metabolism;Valine, leucine and isoleucine degradation : Amino acid metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism Z1_02312 fixA ko:K03521 Required for anaerobic carnitine reduction. May bring reductant to CaiA NA Z1_02313 caiT ko:K05245 Catalyzes the exchange of L-carnitine for gamma- butyrobetaine and related betaines NA Z1_02314 caiA ko:K08297 1.3.8.13 Catalyzes the reduction of crotonobetainyl-CoA to gamma- butyrobetainyl-CoA NA Z1_02315 caiB ko:K08298 2.8.3.21 Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl- CoA and gamma-butyrobetaine. Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl- CoA or L-carnitinyl-CoA to crotonobetaine to generate crotonobetainyl-CoA NA Z1_02316 caiC ko:K02182 6.2.1.48 Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle NA Z1_02317 caiD ko:K08299 4.2.1.149 Catalyzes the reversible dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA NA Z1_02318 caiE ko:K02617,ko:K08279 Bacterial transferase hexapeptide (six repeats) NA Z1_02319 caiF ko:K08277 CaiF/GrlA transcriptional regulator NA Z1_02320 tal ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 ko:K00616,ko:K08313,ko:K08314 2.2.1.2 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_02321 ko:K03933 Lytic polysaccharide mono-oxygenase, cellulose-degrading NA Z1_02322 recX ko:K03565 Modulates RecA activity NA Z1_02326 bax ko:K03796 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase NA Z1_02327 algI ko:K19294 membrane protein involved in D-alanine export NA Z1_02328 Z012_00175 ko:K09795 Protein of unknown function (DUF459) NA Z1_02329 Z012_00180 ko01040,map01040 ko:K10804 3.1.1.5 GDSL-like Lipase/Acylhydrolase family Biosynthesis of unsaturated fatty acids : Lipid metabolism : Metabolism Z1_02331 gntU ko:K03299,ko:K06156 GntP family permease NA Z1_02332 gntK ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 ko:K00851 2.7.1.12 Gluconokinase Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism Z1_02333 gntR ko:K06145 Periplasmic binding protein domain NA Z1_02334 ko02010,map02010 ko:K02016,ko:K02049 Periplasmic binding protein ABC transporters : Membrane transport : Environmental Information Processing Z1_02335 ko02010,map02010 ko:K02015 ABC 3 transport family ABC transporters : Membrane transport : Environmental Information Processing Z1_02336 ko02010,map02010 ko:K02013,ko:K09817 3.6.3.34 ABC transporter ABC transporters : Membrane transport : Environmental Information Processing Z1_02338 nadC ko00760,ko01100,map00760,map01100 ko:K00767,ko:K03813 2.4.2.19 Belongs to the NadC ModD family Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02339 prrA ko:K02014 TonB dependent receptor NA Z1_02340 ko05100,ko05131,ko05132,map05100,map05131,map05132 ko:K13287 Invasion plasmid antigen IpaD Bacterial invasion of epithelial cells : Infectious disease: bacterial : Human Diseases;Shigellosis : Infectious disease: bacterial : Human Diseases;Salmonella infection : Infectious disease: bacterial : Human Diseases Z1_02342 ko05100,ko05131,ko05132,map05100,map05131,map05132 ko:K13285 Secretion system effector C (SseC) like family Bacterial invasion of epithelial cells : Infectious disease: bacterial : Human Diseases;Shigellosis : Infectious disease: bacterial : Human Diseases;Salmonella infection : Infectious disease: bacterial : Human Diseases Z1_02344 flhB ko02040,ko03070,map02040,map03070 ko:K02401,ko:K03229,ko:K04061,ko:K22510 FlhB HrpN YscU SpaS Family Flagellar assembly : Cell motility : Cellular Processes;Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_02345 epaR ko02040,ko03070,map02040,map03070 ko:K02421,ko:K03228,ko:K22509 type III secretion apparatus protein SpaR YscT HrcT Flagellar assembly : Cell motility : Cellular Processes;Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_02346 rhcS ko02040,ko03070,map02040,map03070 ko:K02420,ko:K03227,ko:K22508 Bacterial export proteins, family 3 Flagellar assembly : Cell motility : Cellular Processes;Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_02347 ko:K22507 FliP family NA Z1_02348 spaO ko02030,ko02040,ko03070,map02030,map02040,map03070 ko:K02416,ko:K03225 Type III flagellar switch regulator (C-ring) FliN C-term Bacterial chemotaxis : Cell motility : Cellular Processes;Flagellar assembly : Cell motility : Cellular Processes;Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_02351 invC ko03070,map03070 ko:K03224,ko:K22506 3.6.3.14 Type III Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_02352 invB ko:K22512 Invasion protein B family NA Z1_02353 invA ko03070,map03070 ko:K03230 Psort location CytoplasmicMembrane, score Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_02354 ysaW ko03070,map03070 ko:K04058,ko:K22511 type III secretion regulator YopN LcrE InvE MxiC Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_02355 ysaC ko:K22504 Type III secretion outer membrane pore, YscC HrcC family NA Z1_02358 prgI ko03070,map03070 ko:K03221 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_02360 ko03070,map03070 ko:K03222,ko:K22505 Secretory protein of YscJ/FliF family Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_02364 soxR ko:K13639 helix_turn_helix, mercury resistance NA Z1_02365 ko:K15977,ko:K18305 DoxX NA Z1_02366 mdtA_1 ko01501,ko01503,ko02024,map01501,map01503,map02024 ko:K03585,ko:K18306 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases;Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_02367 bepE_1 ko01501,ko01503,ko02024,map01501,map01503,map02024 ko:K18138,ko:K18307 Psort location CytoplasmicMembrane, score beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases;Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_02368 yopH ko:K04055 Phosphatase NA Z1_02369 emrE ko:K03297 Small Multidrug Resistance protein NA Z1_02370 emrE ko:K03297 Small Multidrug Resistance protein NA Z1_02372 pduL ko00430,ko00620,ko00640,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00720,map01100,map01120,map01200 ko:K15024 2.3.1.8 Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate Taurine and hypotaurine metabolism : Metabolism of other amino acids : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism Z1_02374 cutD ko:K20037 Catalyzes activation of the choline trimethylamine-lyase CutC under anaerobic conditions by generation of an organic free radical on a glycine residue, via an homolytic cleavage of S- adenosyl-L-methionine (SAM) NA Z1_02375 cutC ko:K20038 4.3.99.4 Glycine radical enzyme that catalyzes the cleavage of a C-N bond in choline, producing trimethylamine (TMA) and acetaldehyde NA Z1_02377 ccmL ko:K04028 Ethanolamine utilisation protein EutN/carboxysome NA Z1_02379 pduA ko:K04027 BMC domain NA Z1_02380 pduA_3 ko:K04027 BMC domain NA Z1_02381 pduA_4 ko:K04027 BMC domain NA Z1_02387 fimA ko05133,map05133 ko:K07345 Fimbrial protein Pertussis : Infectious disease: bacterial : Human Diseases Z1_02388 ko:K07346,ko:K12519 Pili assembly chaperone PapD, C-terminal domain NA Z1_02389 ko05133,map05133 ko:K07347 Outer membrane usher protein Pertussis : Infectious disease: bacterial : Human Diseases Z1_02391 yadC ko:K07350 Fimbrial protein NA Z1_02392 ko02024,map02024 ko:K20391 Helix-turn-helix XRE-family like proteins Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_02393 potD ko02010,map02010 ko:K11069,ko:K11070 Required for the activity of the bacterial periplasmic transport system of putrescine ABC transporters : Membrane transport : Environmental Information Processing Z1_02394 potC ko02010,map02010 ko:K11070 Binding-protein-dependent transport system inner membrane component ABC transporters : Membrane transport : Environmental Information Processing Z1_02395 potB ko02010,map02010 ko:K11071 Binding-protein-dependent transport system inner membrane component ABC transporters : Membrane transport : Environmental Information Processing Z1_02397 ko02024,map02024 ko:K14645 Subtilase family Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_02401 alr ko00473,ko01100,ko01502,map00473,map01100,map01502 ko:K01775 5.1.1.1 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids D-Alanine metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Vancomycin resistance : Drug resistance: antimicrobial : Human Diseases Z1_02402 tyrB ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 ko:K00813,ko:K00832 2.6.1.1,2.6.1.57 Aminotransferase class I and II Arginine biosynthesis : Amino acid metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Arginine and proline metabolism : Amino acid metabolism : Metabolism;Tyrosine metabolism : Amino acid metabolism : Metabolism;Phenylalanine metabolism : Amino acid metabolism : Metabolism;Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Novobiocin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Isoquinoline alkaloid biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Tropane, piperidine and pyridine alkaloid biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_02404 yhaO ko:K03834,ko:K03835,ko:K03837 Serine transporter NA Z1_02405 uvrA ko03420,map03420 ko:K03701 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate Nucleotide excision repair : Replication and repair : Genetic Information Processing Z1_02406 ssb ko03030,ko03430,ko03440,map03030,map03430,map03440 ko:K03111 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism DNA replication : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing Z1_02407 zur ko02024,map02024 ko:K02076,ko:K03711,ko:K09823 Ferric uptake regulator family Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_02408 lexA ko:K01356 3.4.21.88 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair NA Z1_02409 dgkA ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00561,map00564,map01100,map01110,map04070,map04072,map05231 ko:K00901 2.7.1.107 Recycling of diacylglycerol produced during the turnover of membrane phospholipid Glycerolipid metabolism : Lipid metabolism : Metabolism;Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Phosphatidylinositol signaling system : Signal transduction : Environmental Information Processing;Phospholipase D signaling pathway : Signal transduction : Environmental Information Processing;Choline metabolism in cancer : Cancer: overview : Human Diseases Z1_02410 plsB ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 ko:K00631 2.3.1.15 Belongs to the GPAT DAPAT family Glycerolipid metabolism : Lipid metabolism : Metabolism;Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_02411 ubiA ko00130,ko01100,ko01110,map00130,map01100,map01110 ko:K03179 2.5.1.39 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_02412 ubiC ko00130,ko01100,ko01110,map00130,map01100,map01110 ko:K03181 4.1.3.40 Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_02413 pgi ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 ko:K01810 5.3.1.9 Phosphoglucose isomerase Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism Z1_02414 HOM3 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 ko:K00928 2.7.2.4 lysine biosynthetic process via diaminopimelate Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Monobactam biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Lysine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_02417 metH ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 ko:K00548 2.1.1.13 B12 binding domain Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Selenocompound metabolism : Metabolism of other amino acids : Metabolism;One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_02418 iclR ko:K13641 helix_turn_helix isocitrate lyase regulation NA Z1_02419 edd ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 ko:K01690 4.2.1.12 Belongs to the IlvD Edd family Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism Z1_02420 eda ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200 ko:K01625 4.1.2.14,4.1.3.42 KDPG and KHG aldolase Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism Z1_02422 aceA ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 ko:K01637 4.1.3.1 isocitrate lyase Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism Z1_02423 aceB ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200 ko:K01638 2.3.3.9 Malate synthase Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism Z1_02424 metAS ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230 ko:K00651 2.3.1.46 Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_02426 idi ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 ko:K01597,ko:K01823 4.1.1.33,5.3.3.2 Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) Terpenoid backbone biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA Z1_02430 uspG ko:K11932,ko:K14061 Universal stress protein family NA Z1_02432 uspF ko:K11932,ko:K14061 Universal stress protein family NA Z1_02433 nnrD ko:K17758,ko:K17759 4.2.1.136,5.1.99.6 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration NA Z1_02436 hemB ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 ko:K01698 4.2.1.24 Delta-aminolevulinic acid dehydratase Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_02437 hit ko:K02503 Diadenosine tetraphosphate NA Z1_02438 codA ko00240,ko00330,ko01100,map00240,map00330,map01100 ko:K01485 3.5.4.1 Amidohydrolase family Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Arginine and proline metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02439 codB ko:K10974 Permease for cytosine/purines, uracil, thiamine, allantoin NA Z1_02440 betA ko00260,ko01100,map00260,map01100 ko:K00108 1.1.99.1 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02441 betB ko00260,ko01100,map00260,map01100 ko:K00130 1.2.1.8 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02442 betI ko:K02167 HTH-type transcriptional regulator BetI NA Z1_02443 betT ko:K02168 Belongs to the BCCT transporter (TC 2.A.15) family NA Z1_02444 pat ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 ko:K00817 2.6.1.9 aminotransferase Histidine metabolism : Amino acid metabolism : Metabolism;Tyrosine metabolism : Amino acid metabolism : Metabolism;Phenylalanine metabolism : Amino acid metabolism : Metabolism;Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Novobiocin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Tropane, piperidine and pyridine alkaloid biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_02446 ko:K07350 Fimbrial protein NA Z1_02447 elfC ko05133,map05133 ko:K07347 Outer membrane usher protein Pertussis : Infectious disease: bacterial : Human Diseases Z1_02448 sfmC ko:K07346,ko:K07353,ko:K12519 Pili assembly chaperone PapD, C-terminal domain NA Z1_02449 fimI ko:K07351 Fimbrial protein NA Z1_02450 ko05133,map05133 ko:K07345 Fimbrial protein Pertussis : Infectious disease: bacterial : Human Diseases Z1_02452 oppF ko01501,ko02010,ko02024,map01501,map02010,map02024 ko:K02032,ko:K10823,ko:K10824,ko:K12372 3.6.3.24 ABC transporter ATP-binding beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_02453 oppD ko01501,ko02010,ko02024,map01501,map02010,map02024 ko:K02031,ko:K02032,ko:K02034,ko:K12371,ko:K15583,ko:K15587 3.6.3.24 ABC transporter beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_02454 oppC ko01501,ko02010,ko02024,map01501,map02010,map02024 ko:K02034,ko:K12370,ko:K15582,ko:K15586 N-terminal TM domain of oligopeptide transport permease C beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_02455 oppB ko01501,ko02010,ko02024,map01501,map02010,map02024 ko:K02033,ko:K15581 Binding-protein-dependent transport system inner membrane component beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_02456 oppA ko01501,ko02010,ko02024,map01501,map02010,map02024 ko:K02035,ko:K15580 ABC transporter substrate-binding protein beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_02457 oppA2 ko01501,ko02010,ko02024,map01501,map02010,map02024 ko:K02035,ko:K15580 Bacterial extracellular solute-binding proteins, family 5 Middle beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_02458 cysG ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 ko:K02302,ko:K02303,ko:K02304,ko:K03795,ko:K13541,ko:K13542 1.3.1.76,2.1.1.107,2.1.1.131,3.7.1.12,4.2.1.75,4.99.1.3,4.99.1.4 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_02459 nirD ko00360,ko00910,ko01120,ko01220,map00360,map00910,map01120,map01220 ko:K00362,ko:K00363,ko:K05710 1.7.1.15 Rieske-like [2Fe-2S] domain Phenylalanine metabolism : Amino acid metabolism : Metabolism;Nitrogen metabolism : Energy metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Degradation of aromatic compounds : Global and overview maps : Metabolism Z1_02460 nirB ko00910,ko01120,map00910,map01120 ko:K00362 1.7.1.15 BFD-like [2Fe-2S] binding domain Nitrogen metabolism : Energy metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_02461 ddpA ko02024,map02024 ko:K02035 Extracellular solute-binding protein, family 5 Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_02462 ddpB ko02024,map02024 ko:K02033 Binding-protein-dependent transport system inner membrane component Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_02463 yddQ ko01501,ko02010,ko02024,map01501,map02010,map02024 ko:K02034,ko:K12370,ko:K15582,ko:K15586 N-terminal TM domain of oligopeptide transport permease C beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_02464 oppD ko01501,ko02010,ko02024,map01501,map02010,map02024 ko:K02031,ko:K02032,ko:K12371,ko:K15583,ko:K15587 3.6.3.24 ATPases associated with a variety of cellular activities beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_02465 gsiA_3 ko02024,map02024 ko:K02032 AAA domain, putative AbiEii toxin, Type IV TA system Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_02466 ychE ko:K05595 MarC family integral membrane protein NA Z1_02467 adhE ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220 ko:K04072 1.1.1.1,1.2.1.10 Iron-containing alcohol dehydrogenase Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Fatty acid degradation : Lipid metabolism : Metabolism;Tyrosine metabolism : Amino acid metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Chloroalkane and chloroalkene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Naphthalene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Degradation of aromatic compounds : Global and overview maps : Metabolism Z1_02468 tdk ko00240,ko00983,ko01100,map00240,map00983,map01100 ko:K00857 2.7.1.21 Thymidine kinase Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Drug metabolism - other enzymes : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02469 hns ko:K03746 Domain in histone-like proteins of HNS family NA Z1_02470 capI ko00520,ko01100,map00520,map01100 ko:K08679 5.1.3.6 Polysaccharide biosynthesis protein Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02472 ycf29 ko02020,ko02030,map02020,map02030 ko:K02485,ko:K03413,ko:K07684 cheY-homologous receiver domain Two-component system : Signal transduction : Environmental Information Processing;Bacterial chemotaxis : Cell motility : Cellular Processes Z1_02473 ychJ ko:K09858 SEC-C motif NA Z1_02474 purU ko00630,ko00670,ko03013,map00630,map00670,map03013 ko:K00974,ko:K01433 2.7.7.72,3.5.1.10 formyltetrahydrofolate deformylase Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;RNA transport : Translation : Genetic Information Processing Z1_02477 xthA ko03410,map03410 ko:K01142 3.1.11.2 exodeoxyribonuclease III Base excision repair : Replication and repair : Genetic Information Processing Z1_02478 topB ko:K03169 5.99.1.2 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone NA Z1_02479 selD ko00450,ko01100,map00450,map01100 ko:K01008 2.7.9.3 Selenide, water dikinase Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02481 sppA ko:K04773,ko:K04774 signal peptide peptidase NA Z1_02483 pncA ko00760,ko01100,map00760,map01100 ko:K08281,ko:K12132 2.7.11.1,3.5.1.19 Isochorismatase family Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02484 yeaC ko:K09916 Protein of unknown function (DUF1315) NA Z1_02485 msrB ko:K07305 1.8.4.12 SelR domain NA Z1_02487 yeaD ko00010,ko00290,ko00770,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00010,map00290,map00770,map01100,map01110,map01120,map01130,map01210,map01230 ko:K01687,ko:K01792 4.2.1.9,5.1.3.15 Aldose 1-epimerase Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Valine, leucine and isoleucine biosynthesis : Amino acid metabolism : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_02488 mipA ko:K07274 MltA-interacting protein MipA NA Z1_02489 hypF ko:K04656 Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide NA Z1_02490 alr ko00473,ko01100,ko01502,map00473,map01100,map01502 ko:K01775 5.1.1.1 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids D-Alanine metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Vancomycin resistance : Drug resistance: antimicrobial : Human Diseases Z1_02491 dadA ko00360,map00360 ko:K00285 1.4.5.1 FAD dependent oxidoreductase Phenylalanine metabolism : Amino acid metabolism : Metabolism Z1_02492 fadR ko:K03603,ko:K05799,ko:K22104 Multifunctional regulator of fatty acid metabolism NA Z1_02493 nhaB ko:K03314 ) H( ) antiporter that extrudes sodium in exchange for external protons NA Z1_02494 dsbB ko:K03611 disulfide bond formation protein B NA Z1_02495 ydbJ ko05143,map05143 ko:K09712,ko:K14475 Domain of unknown function (DUF333) African trypanosomiasis : Infectious disease: parasitic : Human Diseases Z1_02496 emrE ko:K03297 Small Multidrug Resistance protein NA Z1_02497 sotB ko:K03445,ko:K08159 Major Facilitator Superfamily NA Z1_02500 yohM ko:K08970 Belongs to the NiCoT transporter (TC 2.A.52) family NA Z1_02501 MA20_06510 ko00190,ko03018,map00190,map03018 ko:K00937,ko:K06925 2.7.4.1 transport system periplasmic component Oxidative phosphorylation : Energy metabolism : Metabolism;RNA degradation : Folding, sorting and degradation : Genetic Information Processing Z1_02507 pgsA ko00564,ko01100,map00564,map01100 ko:K00995,ko:K08744 2.7.8.41,2.7.8.5 Belongs to the CDP-alcohol phosphatidyltransferase class-I family Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02508 uvrC ko03420,map03420 ko:K03703 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision Nucleotide excision repair : Replication and repair : Genetic Information Processing Z1_02509 uvrY ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 ko:K02282,ko:K07687,ko:K07689,ko:K20264 helix_turn_helix, Lux Regulon Two-component system : Signal transduction : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes Z1_02510 ydgI ko:K15976 Nitroreductase NA Z1_02511 glpX ko00010,ko00030,ko00051,ko00680,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 ko:K00615,ko:K02446,ko:K11532 2.2.1.1,3.1.3.11,3.1.3.37 Bacterial fructose-1,6-bisphosphatase, glpX-encoded Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Biosynthesis of ansamycins : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_02512 pteR ko:K07048 Phosphotriesterase family NA Z1_02513 ko02024,map02024 ko:K09936 Putative inner membrane exporter, YdcZ Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_02515 rbsK ko00030,ko00051,ko00500,ko00520,ko01100,map00030,map00051,map00500,map00520,map01100 ko:K00847,ko:K00852,ko:K02444 2.7.1.15,2.7.1.4 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02524 ko02010,map02010 ko:K02010,ko:K02017,ko:K11076 3.6.3.29,3.6.3.30 ATPases associated with a variety of cellular activities ABC transporters : Membrane transport : Environmental Information Processing Z1_02525 modB1 ko02010,map02010 ko:K02018 Binding-protein-dependent transport system inner membrane component ABC transporters : Membrane transport : Environmental Information Processing Z1_02526 modA2 ko02010,map02010 ko:K02020 Bacterial extracellular solute-binding protein ABC transporters : Membrane transport : Environmental Information Processing Z1_02527 yjhU ko:K05346 Putative sugar-binding domain NA Z1_02528 cutA ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 ko:K01733,ko:K03926 4.2.3.1 CutA1 divalent ion tolerance protein Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Vitamin B6 metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_02530 ko:K07074 Predicted nucleotidyltransferase NA Z1_02531 ycgL ko:K07074 Predicted nucleotidyltransferase NA Z1_02532 ko00790,ko01100,map00790,map01100 ko:K03752,ko:K04095 2.7.7.77 Fic/DOC family Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02543 rlmD ko03013,map03013 ko:K03215,ko:K06969,ko:K14292 2.1.1.190,2.1.1.191 Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA RNA transport : Translation : Genetic Information Processing Z1_02545 guaA ko00230,ko00983,ko01100,map00230,map00983,map01100 ko:K01951 6.3.5.2 Catalyzes the synthesis of GMP from XMP Purine metabolism : Nucleotide metabolism : Metabolism;Drug metabolism - other enzymes : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02546 guaB ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 ko:K00088 1.1.1.205 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth Purine metabolism : Nucleotide metabolism : Metabolism;Drug metabolism - other enzymes : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_02547 xseA ko03430,map03430 ko:K03601 3.1.11.6 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides Mismatch repair : Replication and repair : Genetic Information Processing Z1_02548 hasR ko:K16087,ko:K16152 TonB dependent receptor NA Z1_02550 tonB ko:K03832 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins NA Z1_02552 maeB ko00430,ko00620,ko00640,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,ko02020,map00430,map00620,map00640,map00680,map00710,map00720,map01100,map01120,map01200,map02020 ko:K00027,ko:K00029,ko:K00625,ko:K13788 1.1.1.38,1.1.1.40,2.3.1.8 Malic enzyme, NAD binding domain Taurine and hypotaurine metabolism : Metabolism of other amino acids : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing Z1_02553 narP ko02020,map02020 ko:K02479,ko:K07685 Response regulator receiver domain Two-component system : Signal transduction : Environmental Information Processing Z1_02555 yffB ko:K00537,ko:K16509 1.20.4.1 ArsC family NA Z1_02556 dapE ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 ko:K01439 3.5.1.18 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls Lysine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_02558 ko:K07454 HNH endonuclease NA Z1_02560 dgt ko00230,map00230 ko:K01129 3.1.5.1 dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs Purine metabolism : Nucleotide metabolism : Metabolism Z1_02561 cca ko03013,ko03018,map03013,map03018 ko:K00970,ko:K00974 2.7.7.19,2.7.7.72 tRNA 3'-terminal CCA addition RNA transport : Translation : Genetic Information Processing;RNA degradation : Folding, sorting and degradation : Genetic Information Processing Z1_02565 ko:K18831 Pfam:DUF955 NA Z1_02566 ko:K19166 protein conserved in bacteria NA Z1_02570 ampH ko:K18988 3.4.16.4 Beta-lactamase NA Z1_02571 lptG ko02010,map02010 ko:K11720 Predicted permease YjgP/YjgQ family ABC transporters : Membrane transport : Environmental Information Processing Z1_02572 lptF ko02010,map02010 ko:K07091,ko:K11720 Predicted permease YjgP/YjgQ family ABC transporters : Membrane transport : Environmental Information Processing Z1_02573 pepA ko00480,ko01100,map00480,map01100 ko:K01255,ko:K07751 3.4.11.1,3.4.11.23 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides Glutathione metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02574 holC ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 ko:K02339 2.7.7.7 DNA polymerase III chi subunit, HolC Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;DNA replication : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing Z1_02575 valS ko00970,map00970 ko:K01873 6.1.1.9 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing Z1_02576 yjgM ko:K03828 Acetyltransferase (GNAT) family NA Z1_02578 yhhW_3 ko:K06911 Belongs to the pirin family NA Z1_02579 rraB ko:K09893 Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome NA Z1_02580 argF ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 ko:K00611 2.1.3.3 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline Arginine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_02582 pyrB ko00240,ko00250,ko01100,map00240,map00250,map01100 ko:K00609 2.1.3.2 Belongs to the ATCase OTCase family Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02583 pyrI ko00240,ko00250,ko01100,map00240,map00250,map01100 ko:K00608,ko:K00610 2.1.3.2 Involved in allosteric regulation of aspartate carbamoyltransferase Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02584 yjgF ko:K09022 3.5.99.10 Endoribonuclease L-PSP NA Z1_02585 nrdD ko00230,ko00240,ko01100,map00230,map00240,map01100 ko:K21636 1.1.98.6 Anaerobic ribonucleoside-triphosphate reductase Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02586 nrdG ko:K04068 1.97.1.4 Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine NA Z1_02589 yhbP ko:K09979 Belongs to the UPF0306 family NA Z1_02591 yhbQ ko:K07461 GIY-YIG catalytic domain NA Z1_02592 yhbS ko:K03824 Acetyltransferase (GNAT) domain NA Z1_02593 yhbT ko05120,map05120 ko:K08303 SCP-2 sterol transfer family Epithelial cell signaling in Helicobacter pylori infection : Infectious disease: bacterial : Human Diseases Z1_02594 yhbU ko05120,map05120 ko:K08303 Peptidase family U32 Epithelial cell signaling in Helicobacter pylori infection : Infectious disease: bacterial : Human Diseases Z1_02596 ydeQ ko:K07350 Fimbrial protein NA Z1_02597 ydeR ko:K07349 Fimbrial protein NA Z1_02598 fimF ko:K07348 Fimbrial protein NA Z1_02599 fimD ko05133,map05133 ko:K07347 Usher protein Pertussis : Infectious disease: bacterial : Human Diseases Z1_02600 fimD ko05133,map05133 ko:K07347 Usher protein Pertussis : Infectious disease: bacterial : Human Diseases Z1_02601 fimC ko:K07346,ko:K12519 chaperone NA Z1_02602 fimA ko05133,map05133 ko:K07345 Fimbrial protein Pertussis : Infectious disease: bacterial : Human Diseases Z1_02603 ko:K01992 ABC-2 type transporter NA Z1_02604 ko:K01992 ABC-2 family transporter protein NA Z1_02605 farA ko:K01993,ko:K02005 Barrel-sandwich domain of CusB or HlyD membrane-fusion NA Z1_02606 yehU ko02020,map02020 ko:K02478,ko:K07704 2.7.13.3 sensory kinase in two-component system with YehT K07704 Two-component system : Signal transduction : Environmental Information Processing Z1_02612 ko:K09022 3.5.99.10 Endoribonuclease L-PSP NA Z1_02615 deaD ko03018,map03018 ko:K05591,ko:K05592 3.6.4.13 DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation RNA degradation : Folding, sorting and degradation : Genetic Information Processing Z1_02617 pnp ko00230,ko00240,ko03018,map00230,map00240,map03018 ko:K00962 2.7.7.8 polyribonucleotide nucleotidyltransferase Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;RNA degradation : Folding, sorting and degradation : Genetic Information Processing Z1_02618 rpsO ko03010,map03010 ko:K02956 Ribosomal_S15 Ribosome : Translation : Genetic Information Processing Z1_02619 truB ko:K03177 5.4.99.25 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs NA Z1_02620 rbfA ko:K02834 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA NA Z1_02621 infB ko:K02519 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex NA Z1_02622 nusA ko:K02600 Participates in both transcription termination and antitermination NA Z1_02623 rimP ko:K09748 Required for maturation of 30S ribosomal subunits NA Z1_02626 secG ko02024,ko03060,ko03070,map02024,map03060,map03070 ko:K03075 Preprotein translocase SecG subunit Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Protein export : Folding, sorting and degradation : Genetic Information Processing;Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_02627 glmM ko00520,ko01100,ko01130,map00520,map01100,map01130 ko:K03431 5.4.2.10 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;NA : NA : NA Z1_02628 folP ko00790,ko01100,map00790,map01100 ko:K00796 2.5.1.15 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02629 ftsH ko:K03798 Belongs to the AAA ATPase family NA Z1_02630 ftsJ ko:K02427 2.1.1.166 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit NA Z1_02631 yhbY ko:K07574 CRS1_YhbY NA Z1_02632 greA ko:K03624 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides NA Z1_02634 obg ko:K03979 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control NA Z1_02635 rpmA ko03010,map03010 ko:K02899 Ribosomal L27 protein Ribosome : Translation : Genetic Information Processing Z1_02636 rplU ko03010,map03010 ko:K02888 This protein binds to 23S rRNA in the presence of protein L20 Ribosome : Translation : Genetic Information Processing Z1_02637 ispB ko00900,ko01110,map00900,map01110 ko:K00805,ko:K02523 2.5.1.30,2.5.1.90 Polyprenyl synthetase Terpenoid backbone biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_02640 sfsB ko:K07724 Winged helix-turn-helix DNA-binding NA Z1_02641 mdh ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 ko:K00024 1.1.1.37 Catalyzes the reversible oxidation of malate to oxaloacetate Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism Z1_02642 argR ko:K03402 Regulates arginine biosynthesis genes NA Z1_02643 murC ko00471,ko00473,ko00550,ko01100,ko01502,map00471,map00473,map00550,map01100,map01502 ko:K01921,ko:K01924,ko:K02558 6.3.2.4,6.3.2.45,6.3.2.8 Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate D-Glutamine and D-glutamate metabolism : Metabolism of other amino acids : Metabolism;D-Alanine metabolism : Metabolism of other amino acids : Metabolism;Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Vancomycin resistance : Drug resistance: antimicrobial : Human Diseases Z1_02644 fbp ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910 ko:K03841 3.1.3.11 Fructose-1-6-bisphosphatase, N-terminal domain Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;AMPK signaling pathway : Signal transduction : Environmental Information Processing;Insulin signaling pathway : Endocrine system : Organismal Systems Z1_02645 ppa ko00190,map00190 ko:K01507 3.6.1.1 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions Oxidative phosphorylation : Energy metabolism : Metabolism Z1_02650 ytfN ko:K09800 TamB, inner membrane protein subunit of TAM complex NA Z1_02651 ytfM ko:K07278 POTRA domain TamA domain 1 NA Z1_02652 msrA ko:K07304 1.8.4.11 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine NA Z1_02653 ytfL ko:K03699 Hemolysins and related proteins containing CBS domains NA Z1_02655 ytfJ ko:K07109 Bacterial protein of unknown function (YtfJ_HI0045) NA Z1_02656 cysQ ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130 ko:K01082 3.1.3.7 Inositol monophosphatase family Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA Z1_02657 fklB ko:K03773 5.2.1.8 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase NA Z1_02658 gabD ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 ko:K00135 1.2.1.16,1.2.1.20,1.2.1.79 Aldehyde dehydrogenase family Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Lysine degradation : Amino acid metabolism : Metabolism;Tyrosine metabolism : Amino acid metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_02659 adcA ko02010,map02010 ko:K09815 ZinT (YodA) periplasmic lipocalin-like zinc-recruitment ABC transporters : Membrane transport : Environmental Information Processing Z1_02660 rpmJ ko03010,map03010 ko:K02919 Ribosomal protein L36 Ribosome : Translation : Genetic Information Processing Z1_02661 rpmE2 ko03010,map03010 ko:K02909 Ribosomal protein L31 Ribosome : Translation : Genetic Information Processing Z1_02662 ytfB ko:K07268,ko:K07269 Opacity-associated protein A N-terminal motif NA Z1_02663 rplI ko03010,map03010 ko:K02939 ribosomal protein L9 Ribosome : Translation : Genetic Information Processing Z1_02664 rpsR ko03010,map03010 ko:K02963 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit Ribosome : Translation : Genetic Information Processing Z1_02665 priB ko03440,map03440 ko:K02686 Binds single-stranded DNA at the primosome assembly site (PAS) Homologous recombination : Replication and repair : Genetic Information Processing Z1_02666 rpsF ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,ko03010,map00260,map00290,map01100,map01110,map01130,map01200,map01230,map03010 ko:K01754,ko:K02990 4.3.1.19 Binds together with S18 to 16S ribosomal RNA Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Valine, leucine and isoleucine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism;Ribosome : Translation : Genetic Information Processing Z1_02667 rlmB ko:K00556,ko:K03214,ko:K03218,ko:K22132 2.1.1.185,2.1.1.34 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily NA Z1_02668 rnr ko03018,map03018 ko:K12573 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs RNA degradation : Folding, sorting and degradation : Genetic Information Processing Z1_02669 nsrR ko05132,map05132 ko:K13771 Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress. May require iron for activity Salmonella infection : Infectious disease: bacterial : Human Diseases Z1_02670 purA ko00230,ko00250,ko01100,map00230,map00250,map01100 ko:K01939 6.3.4.4 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP Purine metabolism : Nucleotide metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02671 hflC ko:K04087 HflC and HflK could regulate a protease NA Z1_02672 hflK ko:K04088 HflC and HflK could encode or regulate a protease NA Z1_02673 hflX ko:K03665 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis NA Z1_02674 hfq ko02024,ko03018,ko05111,map02024,map03018,map05111 ko:K03666 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs Quorum sensing : Cellular community - prokaryotes : Cellular Processes;RNA degradation : Folding, sorting and degradation : Genetic Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes Z1_02675 miaA ko00908,ko01100,ko01110,map00908,map01100,map01110 ko:K00791 2.5.1.75 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) Zeatin biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_02676 mutL ko03430,map03430 ko:K03572 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex Mismatch repair : Replication and repair : Genetic Information Processing Z1_02677 amiB ko01503,map01503 ko:K01448 3.5.1.28 N-acetylmuramoyl-L-alanine amidase Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases Z1_02678 yjeE ko:K06925 Threonylcarbamoyl adenosine biosynthesis protein TsaE NA Z1_02679 queG ko:K18979 1.17.99.6 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) NA Z1_02681 ko:K19092 ParE toxin of type II toxin-antitoxin system, parDE NA Z1_02685 orn ko03008,map03008 ko:K13288 3'-to-5' exoribonuclease specific for small oligoribonucleotides Ribosome biogenesis in eukaryotes : Translation : Genetic Information Processing Z1_02686 rsgA ko00730,ko01100,map00730,map01100 ko:K06949 3.1.3.100 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit Thiamine metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02687 psd ko00564,ko01100,ko01110,map00564,map01100,map01110 ko:K01613 4.1.1.65 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_02688 yjeP ko:K05802,ko:K22051 Mechanosensitive ion channel inner membrane domain 1 NA Z1_02690 allS ko:K10972 LysR substrate binding domain NA Z1_02691 ko05133,map05133 ko:K07345 Fimbrial protein Pertussis : Infectious disease: bacterial : Human Diseases Z1_02692 ko:K07346,ko:K12519 Pili assembly chaperone PapD, C-terminal domain NA Z1_02693 ko05133,map05133 ko:K07347 usher protein Pertussis : Infectious disease: bacterial : Human Diseases Z1_02695 ko00500,ko01100,map00500,map01100 ko:K01179 3.2.1.4 Large extracellular alpha-helical protein Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02696 ko:K12543 efflux transmembrane transporter activity NA Z1_02697 hlyB ko02010,map02010 ko:K12541 COG2274 ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain ABC transporters : Membrane transport : Environmental Information Processing Z1_02698 ko:K02022,ko:K12542 Type I secretion membrane fusion protein, HlyD NA Z1_02699 nemR ko:K16137 transcriptional regulator NA Z1_02700 potE ko:K03294,ko:K03756 Catalyzes both the uptake and excretion of putrescine. The uptake of putrescine is dependent on the membrane potential and the excretion involves putrescine-ornithine antiporter activity NA Z1_02701 speC ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130 ko:K01581,ko:K01585 4.1.1.17,4.1.1.19 orn Lys Arg decarboxylase Arginine and proline metabolism : Amino acid metabolism : Metabolism;Glutathione metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA Z1_02704 proV ko02010,map02010 ko:K02000 3.6.3.32 transcriptional regulator ABC transporters : Membrane transport : Environmental Information Processing Z1_02708 mutY ko03410,map03410 ko:K03575 A G-specific adenine glycosylase Base excision repair : Replication and repair : Genetic Information Processing Z1_02709 trmB ko00540,ko01100,map00540,map01100 ko:K02493,ko:K02527,ko:K03439 2.1.1.297,2.1.1.33,2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02710 yggL ko:K09923 Protein with unknown function (DUF469) NA Z1_02711 glsA ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230 ko:K01425 3.5.1.2 Belongs to the glutaminase family Arginine biosynthesis : Amino acid metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;D-Glutamine and D-glutamate metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Glutamatergic synapse : Nervous system : Organismal Systems;GABAergic synapse : Nervous system : Organismal Systems;Proximal tubule bicarbonate reclamation : Excretory system : Organismal Systems;MicroRNAs in cancer : Cancer: overview : Human Diseases;Central carbon metabolism in cancer : Cancer: overview : Human Diseases Z1_02713 fatB ko02010,map02010 ko:K02016 Periplasmic binding protein ABC transporters : Membrane transport : Environmental Information Processing Z1_02715 rdgB ko00230,ko00471,ko01100,map00230,map00471,map01100 ko:K01776,ko:K02428 3.6.1.66,5.1.1.3 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions Purine metabolism : Nucleotide metabolism : Metabolism;D-Glutamine and D-glutamate metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02716 yggT ko:K02221 YGGT family NA Z1_02717 proC ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 ko:K00286 1.5.1.2 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline Arginine and proline metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_02718 yggS ko:K06997 Pyridoxal phosphate NA Z1_02719 yggR ko:K02669 Type II/IV secretion system protein NA Z1_02720 yqgF ko:K07447 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA NA Z1_02721 yqgE ko:K07735 Uncharacterized ACR, COG1678 NA Z1_02722 gshB ko00270,ko00480,ko01100,map00270,map00480,map01100 ko:K01919,ko:K01920,ko:K05844 6.3.2.2,6.3.2.3 Prokaryotic glutathione synthetase, N-terminal domain Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Glutathione metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02723 rsmE ko:K09761 2.1.1.193 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit NA Z1_02724 hofD ko03070,map03070 ko:K02464,ko:K02506,ko:K02654 3.4.23.43 Type IV leader peptidase family Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_02725 ko:K07396 Protein-disulfide isomerase NA Z1_02729 lysA ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230 ko:K01586,ko:K12526 2.7.2.4,4.1.1.20 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Monobactam biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Lysine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_02730 fadE ko00071,ko01100,ko01212,map00071,map01100,map01212 ko:K06445 acyl-CoA dehydrogenase YafH of Escherichia coli K06445 Fatty acid degradation : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism Z1_02731 gmhA ko00540,ko01100,map00540,map01100 ko:K03271,ko:K12961 5.3.1.28 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02735 nqrB ko01059,ko01130,map01059,map01130 ko:K00347,ko:K21163 1.6.5.8 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol Biosynthesis of enediyne antibiotics : Metabolism of terpenoids and polyketides : Metabolism;NA : NA : NA Z1_02736 nqrC ko:K00348 1.6.5.8 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol NA Z1_02737 nqrD ko:K00349 1.6.5.8 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol NA Z1_02738 nqrE ko:K00350 1.6.5.8 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol NA Z1_02739 nqrF ko:K00351 1.6.5.8 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway NA Z1_02740 apbE ko:K03734 2.7.1.180 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein NA Z1_02741 Z012_07620 ko:K03734,ko:K05952 2.7.1.180 (Na+)-NQR maturation NqrM NA Z1_02743 glpQ ko00564,map00564 ko:K01126 3.1.4.46 Glycerophosphoryl diester phosphodiesterase family Glycerophospholipid metabolism : Lipid metabolism : Metabolism Z1_02744 dinB ko:K02346,ko:K03502 2.7.7.7 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII NA Z1_02745 fhuA ko:K02014 TonB dependent receptor NA Z1_02746 pepD ko00480,ko01100,map00480,map01100 ko:K01270 aminoacyl-histidine dipeptidase (XAA-His dipeptidase) (beta-alanyl-histidine dipeptidase) (carnosinase) (peptidase D) K01270 Glutathione metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02747 gpt ko00230,ko01100,ko01110,map00230,map01100,map01110 ko:K00769,ko:K07101 2.4.2.22 Acts on guanine, xanthine and to a lesser extent hypoxanthine Purine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_02748 frsA ko:K11750 Alpha/beta hydrolase of unknown function (DUF1100) NA Z1_02749 crl ko:K11926 Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 NA Z1_02750 proB ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 ko:K00931 2.7.2.11 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate Arginine and proline metabolism : Amino acid metabolism : Metabolism;Carbapenem biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_02751 proA ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 ko:K00147 1.2.1.41 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate Arginine and proline metabolism : Amino acid metabolism : Metabolism;Carbapenem biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_02752 aroK ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 ko:K00891,ko:K13829,ko:K15546 2.7.1.71,4.2.3.4 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_02753 aas ko00071,ko00564,map00071,map00564 ko:K05939 2.3.1.40,6.2.1.20 Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1 Fatty acid degradation : Lipid metabolism : Metabolism;Glycerophospholipid metabolism : Lipid metabolism : Metabolism Z1_02754 lplT ko:K08227 Major Facilitator Superfamily NA Z1_02755 ygaD ko00760,map00760 ko:K03742,ko:K03743 3.5.1.42 Competence-damaged protein Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism Z1_02757 alaS ko00970,map00970 ko:K01872 6.1.1.7 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing Z1_02758 csrA ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 ko:K03563 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding Two-component system : Signal transduction : Environmental Information Processing;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes Z1_02765 gshA ko00270,ko00480,ko01100,map00270,map00480,map01100 ko:K01919 6.3.2.2 Glutamate-cysteine ligase Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Glutathione metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02766 luxS ko00270,ko01100,ko01230,ko02024,ko02026,ko05111,map00270,map01100,map01230,map02024,map02026,map05111 ko:K07173 4.4.1.21 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism;Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes Z1_02767 yfjD ko:K03699 CBS domain-containing protein K00638 NA Z1_02769 ffh ko02024,ko03060,ko03070,map02024,map03060,map03070 ko:K03106 3.6.5.4 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Protein export : Folding, sorting and degradation : Genetic Information Processing;Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_02770 rpsP ko03010,map03010 ko:K02959 Ribosomal protein S16 Ribosome : Translation : Genetic Information Processing Z1_02771 rimM ko:K02860 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes NA Z1_02772 trmD ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 ko:K00554,ko:K01770 2.1.1.228,4.6.1.12 Belongs to the RNA methyltransferase TrmD family Terpenoid backbone biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA Z1_02773 rplS ko03010,map03010 ko:K02884 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site Ribosome : Translation : Genetic Information Processing Z1_02774 aroF ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 ko:K01626 2.5.1.54 phospho-2-dehydro-3-deoxyheptonate aldolase, Tyr-sensitive (phospho-2-keto-3-deoxyheptonate aldolase) (DAHP synthetase) K01626 Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism;Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_02775 tyrA ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 ko:K00210,ko:K00211,ko:K00220,ko:K04092,ko:K04093,ko:K04517,ko:K14187 1.3.1.12,1.3.1.13,1.3.1.43,5.4.99.5 T-protein Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Novobiocin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_02778 dcuB ko02020,map02020 ko:K07791,ko:K07792 Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane Two-component system : Signal transduction : Environmental Information Processing Z1_02779 pheA ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 ko:K00661,ko:K03856,ko:K04092,ko:K04093,ko:K04516,ko:K04518,ko:K14170,ko:K14187 1.3.1.12,2.3.1.79,2.5.1.54,4.2.1.51,5.4.99.5 Psort location Cytoplasmic, score Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Novobiocin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_02780 hpf ko:K05808,ko:K05809 Sigma 54 modulation protein / S30EA ribosomal protein NA Z1_02781 bamD ko:K05807,ko:K08309 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamA, the core component of the assembly machinery NA Z1_02782 rluD ko:K06177,ko:K06180 5.4.99.23,5.4.99.28,5.4.99.29 Responsible for synthesis of pseudouridine from uracil NA Z1_02783 yfiH ko:K05810 Multi-copper polyphenol oxidoreductase laccase NA Z1_02784 clpB ko04213,map04213 ko:K03694,ko:K03695 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE Longevity regulating pathway - multiple species : Aging : Organismal Systems Z1_02786 hipB ko:K15773 Helix-turn-helix XRE-family like proteins NA Z1_02787 hipA ko:K07154 2.7.11.1 Pfam:HipA_N NA Z1_02791 tonB ko:K03832,ko:K07261 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins NA Z1_02792 FrpB2 ko:K02014,ko:K16087 Receptor NA Z1_02793 trxA ko04621,ko05418,map04621,map05418 ko:K03671 Protein of unknown function (DUF560) NOD-like receptor signaling pathway : Immune system : Organismal Systems;Fluid shear stress and atherosclerosis : Cardiovascular disease : Human Diseases Z1_02799 ko:K03824 acetyltransferase NA Z1_02800 ko:K03824 acetyltransferase NA Z1_02801 fdhD ko:K02379 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH NA Z1_02804 fdoH ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 ko:K00124 Formate dehydrogenase N, transmembrane Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism Z1_02805 fdoI ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 ko:K00127 Prokaryotic cytochrome b561 Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism Z1_02806 fdhE ko:K02380 Necessary for formate dehydrogenase activity NA Z1_02807 selA ko00450,ko00970,map00450,map00970 ko:K01042 2.9.1.1 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing Z1_02808 selB ko:K03833 Elongation factor SelB, winged helix NA Z1_02809 ko:K01138 Sulfatase NA Z1_02810 celC ko:K20542 3.2.1.4 Glycosyl hydrolases family 8 NA Z1_02811 galU ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130 ko:K00963 2.7.7.9 Nucleotidyl transferase Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;NA : NA : NA Z1_02814 ko03070,ko05111,map03070,map05111 ko:K02453,ko:K02656,ko:K20543 Cellulose synthase operon protein C C-terminus (BCSC_C) Bacterial secretion system : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes Z1_02815 ko:K08086,ko:K20541 Bacterial cellulose synthase subunit NA Z1_02816 bcsA ko00500,ko01100,ko02026,map00500,map01100,map02026 ko:K00694,ko:K20541 2.4.1.12 Cellulose synthase Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes Z1_02818 nagK ko00520,ko01100,map00520,map01100 ko:K00884 2.7.1.59 ROK family Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02825 htrE_3 ko05133,map05133 ko:K07347 fimbrial usher protein Pertussis : Infectious disease: bacterial : Human Diseases Z1_02826 htrE_3 ko05133,map05133 ko:K07347 fimbrial usher protein Pertussis : Infectious disease: bacterial : Human Diseases Z1_02827 ko:K07346 Pili and flagellar-assembly chaperone, PapD N-terminal domain protein NA Z1_02829 ko:K03446 COG0477 Permeases of the major facilitator superfamily NA Z1_02830 ko:K03543 HlyD membrane-fusion protein of T1SS NA Z1_02831 tetR ko:K18476 Tetracyclin repressor, C-terminal all-alpha domain NA Z1_02833 cpg2 ko:K01295 3.4.17.11 Peptidase dimerisation domain NA Z1_02834 phnX ko00440,ko00630,ko01100,ko01110,ko01120,ko01130,map00440,map00630,map01100,map01110,map01120,map01130 ko:K01091,ko:K03430,ko:K05306 2.6.1.37,3.1.3.18,3.11.1.1 Belongs to the HAD-like hydrolase superfamily. PhnX family Phosphonate and phosphinate metabolism : Metabolism of other amino acids : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA Z1_02838 HA62_21480 ko02010,map02010 ko:K02012 Bacterial extracellular solute-binding protein ABC transporters : Membrane transport : Environmental Information Processing Z1_02839 ko02010,map02010 ko:K02011 Binding-protein-dependent transport system inner membrane component ABC transporters : Membrane transport : Environmental Information Processing Z1_02840 cysA2 ko02010,map02010 ko:K02010 3.6.3.30 Part of the ABC transporter complex FbpABC involved in Fe(3 ) ions import. Responsible for energy coupling to the transport system ABC transporters : Membrane transport : Environmental Information Processing Z1_02841 cysA2 ko02010,map02010 ko:K02010 3.6.3.30 Part of the ABC transporter complex FbpABC involved in Fe(3 ) ions import. Responsible for energy coupling to the transport system ABC transporters : Membrane transport : Environmental Information Processing Z1_02842 glmS ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 ko:K00820 2.6.1.16 aminotransferase isomerizing Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;NA : NA : NA;Insulin resistance : Endocrine and metabolic disease : Human Diseases Z1_02843 glmU ko00520,ko01100,ko01130,map00520,map01100,map01130 ko:K04042 2.3.1.157,2.7.7.23 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;NA : NA : NA Z1_02844 atpC ko00190,ko00195,ko01100,map00190,map00195,map01100 ko:K02114 Produces ATP from ADP in the presence of a proton gradient across the membrane Oxidative phosphorylation : Energy metabolism : Metabolism;Photosynthesis : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02845 atpD ko00190,ko00195,ko01100,map00190,map00195,map01100 ko:K02112 3.6.3.14 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits Oxidative phosphorylation : Energy metabolism : Metabolism;Photosynthesis : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02846 atpG ko00190,ko00195,ko01100,map00190,map00195,map01100 ko:K02115 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex Oxidative phosphorylation : Energy metabolism : Metabolism;Photosynthesis : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02847 atpA ko00190,ko00195,ko01100,map00190,map00195,map01100 ko:K02111 3.6.3.14 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit Oxidative phosphorylation : Energy metabolism : Metabolism;Photosynthesis : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02848 atpH ko00190,ko00195,ko01100,map00190,map00195,map01100 ko:K02113 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation Oxidative phosphorylation : Energy metabolism : Metabolism;Photosynthesis : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02849 atpF ko00190,ko00195,ko01100,map00190,map00195,map01100 ko:K02109 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) Oxidative phosphorylation : Energy metabolism : Metabolism;Photosynthesis : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02850 atpE ko00190,ko00195,ko01100,map00190,map00195,map01100 ko:K02110 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation Oxidative phosphorylation : Energy metabolism : Metabolism;Photosynthesis : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02851 atpB ko00190,ko00195,ko01100,map00190,map00195,map01100 ko:K02108 it plays a direct role in the translocation of protons across the membrane Oxidative phosphorylation : Energy metabolism : Metabolism;Photosynthesis : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02852 atpI ko:K02116 ATP synthase I chain NA Z1_02853 rsmG ko:K03501 2.1.1.170 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA NA Z1_02854 gidA ko:K03495 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 NA Z1_02855 mioC ko:K06205 Flavodoxin NA Z1_02856 asnC ko:K03718 helix_turn_helix ASNC type NA Z1_02857 asnA ko00250,ko00460,ko01100,ko01110,ko01230,map00250,map00460,map01100,map01110,map01230 ko:K01914 6.3.1.1 Aspartate-ammonia ligase Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Cyanoamino acid metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_02862 yieP ko:K19776 FCD NA Z1_02863 yeeF ko:K14052 Amino acid permease NA Z1_02864 cirA ko:K16089 TonB dependent receptor NA Z1_02865 lysP ko:K03293,ko:K11733 Amino acid permease NA Z1_02868 nfo ko03410,map03410 ko:K01151 3.1.21.2 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin Base excision repair : Replication and repair : Genetic Information Processing Z1_02869 rppH_2 ko:K03574 3.6.1.55 NUDIX domain NA Z1_02870 mtr ko:K03834,ko:K03835,ko:K03837 Tryptophan/tyrosine permease family NA Z1_02871 efp ko:K02356 Elongation factor P (EF-P) OB domain NA Z1_02874 lpxT ko:K19803 2.7.4.29 Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1- diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P) NA Z1_02875 spr ko:K13694,ko:K13695 3.4.17.13 NlpC/P60 family NA Z1_02877 bcr ko:K07552 Major Facilitator Superfamily NA Z1_02878 rsuA ko:K06178,ko:K06181,ko:K06183 5.4.99.19,5.4.99.20,5.4.99.22 S4 RNA-binding domain NA Z1_02879 yejH ko:K19789 helicase superfamily c-terminal domain NA Z1_02880 rplY ko03010,map03010 ko:K02897 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance Ribosome : Translation : Genetic Information Processing Z1_02881 ndpA ko:K06899 37-kD nucleoid-associated bacterial protein NA Z1_02882 yejL ko:K09904 Protein of unknown function (DUF1414) NA Z1_02883 yejM ko:K07014 Domain of unknown function (DUF3413) NA Z1_02886 ydeN ko:K07002 esterase of the alpha beta hydrolase fold NA Z1_02888 cmoA ko:K15256 Methyltransferase domain NA Z1_02892 ko:K21459 2.1.1.301 Methyltransferase domain NA Z1_02893 lpxL ko00540,ko01100,map00540,map01100 ko:K02517,ko:K02560,ko:K12974 2.3.1.241,2.3.1.242,2.3.1.243 Lipid A biosynthesis Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02894 cspA ko:K03704 Cold shock protein domain NA Z1_02897 ykgA ko:K05804,ko:K13653 Integron-associated effector binding protein NA Z1_02899 dkgB ko:K06222 1.1.1.346 reductase NA Z1_02901 cbpM ko:K18997 MerR HTH family regulatory protein NA Z1_02902 cbpA ko:K03686,ko:K04082,ko:K05516 displays overlapping activities with DnaJ, but functions under different conditions, probably acting as a molecular chaperone in an adaptive response to environmental stresses other than heat shock. Lacks autonomous chaperone activity NA Z1_02905 ttr ko00261,ko01130,map00261,map01130 ko:K19113 histone acetyltransferase HPA2 and related acetyltransferases Monobactam biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;NA : NA : NA Z1_02907 tusE ko04122,map04122 ko:K11179 Part of a sulfur-relay system Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing Z1_02908 acyP ko00620,ko00627,ko01120,map00620,map00627,map01120 ko:K01512 3.6.1.7 Acylphosphatase Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Aminobenzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_02909 hspQ ko:K11940 Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress NA Z1_02910 yccU ko00270,ko01100,map00270,map01100 ko:K01740,ko:K06929 2.5.1.49 CoA binding domain Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02911 mgsA ko00640,ko01120,map00640,map01120 ko:K01734 4.2.3.3 Methylglyoxal synthase Propanoate metabolism : Carbohydrate metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_02912 helD ko:K03658 3.6.4.12 DNA helicase IV / RNA helicase N terminal NA Z1_02914 sxy ko:K07343 TfoX N-terminal domain NA Z1_02915 sulA ko:K13053,ko:K14160 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division NA Z1_02917 ompA ko:K03286,ko:K03640 OmpA family NA Z1_02918 matP ko:K09911 Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain NA Z1_02919 ycbZ ko:K04770 protease La homolog, YcbZ of Escherichia coli K04770 NA Z1_02920 fabA ko00061,ko01100,ko01212,map00061,map01100,map01212 ko:K01716 4.2.1.59,5.3.3.14 Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length Fatty acid biosynthesis : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism Z1_02922 rmf ko:K03812 During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) NA Z1_02923 ko:K05995,ko:K06888 3.4.13.21 ASCH NA Z1_02924 ymbA ko:K09857 ABC-type transport auxiliary lipoprotein component NA Z1_02925 pqiB ko02010,map02010 ko:K02067,ko:K06192 MlaD protein ABC transporters : Membrane transport : Environmental Information Processing Z1_02926 pqiA ko:K03808 Paraquat-inducible protein A NA Z1_02927 uup ko:K15738 ABC transporter C-terminal domain NA Z1_02928 rlmL ko:K00571,ko:K06969,ko:K07444,ko:K12297 2.1.1.173,2.1.1.191,2.1.1.264,2.1.1.72 Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA NA Z1_02929 ycbX ko05132,map05132 ko:K05916,ko:K07140 1.14.12.17 MOSC N-terminal beta barrel domain Salmonella infection : Infectious disease: bacterial : Human Diseases Z1_02930 zapC ko:K18657 Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ NA Z1_02931 pyrD ko00240,ko01100,map00240,map01100 ko:K00254,ko:K02823,ko:K17828 1.3.1.14,1.3.5.2 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02933 pepN ko00480,ko01100,map00480,map01100 ko:K01256 3.4.11.2 aminopeptidase N Glutathione metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02934 pncB ko00760,ko01100,map00760,map01100 ko:K00763 6.3.4.21 Nicotinate phosphoribosyltransferase Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02936 asnS ko00970,map00970 ko:K01893 6.1.1.22 tRNA synthetases class II (D, K and N) Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing Z1_02937 ompF ko01501,ko02020,map01501,map02020 ko:K09476,ko:K14062 Gram-negative porin beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;Two-component system : Signal transduction : Environmental Information Processing Z1_02938 aspC ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 ko:K00813,ko:K00832 2.6.1.1,2.6.1.57 Aminotransferase class I and II Arginine biosynthesis : Amino acid metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Arginine and proline metabolism : Amino acid metabolism : Metabolism;Tyrosine metabolism : Amino acid metabolism : Metabolism;Phenylalanine metabolism : Amino acid metabolism : Metabolism;Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Novobiocin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Isoquinoline alkaloid biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Tropane, piperidine and pyridine alkaloid biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_02954 ybaL ko:K03455 TrkA-N domain NA Z1_02955 gsk ko00230,ko00562,ko01100,ko01120,map00230,map00562,map01100,map01120 ko:K00856,ko:K00892,ko:K03338 2.7.1.20,2.7.1.73,2.7.1.92 pfkB family carbohydrate kinase Purine metabolism : Nucleotide metabolism : Metabolism;Inositol phosphate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_02956 fepE ko:K05789,ko:K05790 ferric enterobactin NA Z1_02958 adk ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 ko:K00939 2.7.4.3 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism Purine metabolism : Nucleotide metabolism : Metabolism;Thiamine metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA Z1_02959 htpG ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 ko:K04079 chaperone HSP90, heat shock protein C 62.5 K04079 Protein processing in endoplasmic reticulum : Folding, sorting and degradation : Genetic Information Processing;PI3K-Akt signaling pathway : Signal transduction : Environmental Information Processing;Necroptosis : Cell growth and death : Cellular Processes;Antigen processing and presentation : Immune system : Organismal Systems;NOD-like receptor signaling pathway : Immune system : Organismal Systems;Plant-pathogen interaction : Environmental adaptation : Organismal Systems;IL-17 signaling pathway : Immune system : Organismal Systems;Th17 cell differentiation : Immune system : Organismal Systems;Progesterone-mediated oocyte maturation : Endocrine system : Organismal Systems;Estrogen signaling pathway : Endocrine system : Organismal Systems;Pathways in cancer : Cancer: overview : Human Diseases;Prostate cancer : Cancer: specific types : Human Diseases;Fluid shear stress and atherosclerosis : Cardiovascular disease : Human Diseases Z1_02960 purT ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 ko:K08289 2.1.2.2 Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate Purine metabolism : Nucleotide metabolism : Metabolism;One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA Z1_02961 rarD ko:K05786 EamA-like transporter family NA Z1_02962 scrK ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100 ko:K00847 2.7.1.4 pfkB family carbohydrate kinase Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02966 pgsAb ko00564,ko01100,map00564,map01100 ko:K00995 2.7.8.5 CDP-alcohol phosphatidyltransferase Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_02967 plsC ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 ko:K00655 2.3.1.51 Phosphate acyltransferases Glycerolipid metabolism : Lipid metabolism : Metabolism;Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_02968 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 ko:K00981 2.7.7.41 phosphatidate cytidylyltransferase activity Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Phosphatidylinositol signaling system : Signal transduction : Environmental Information Processing Z1_02969 ko:K07052 CAAX protease self-immunity NA Z1_02970 allS ko:K10972 Bacterial regulatory helix-turn-helix protein, lysR family NA Z1_02972 arcC ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200 ko:K00926 2.7.2.2 Belongs to the carbamate kinase family Arginine biosynthesis : Amino acid metabolism : Metabolism;Purine metabolism : Nucleotide metabolism : Metabolism;Nitrogen metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism Z1_02974 sucD ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 ko:K01902,ko:K02381 6.2.1.5 Protein of unknown function (DUF1116) Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;C5-Branched dibasic acid metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism Z1_02975 sucD ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 ko:K01902,ko:K02381 6.2.1.5 Membrane protein FdrA Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;C5-Branched dibasic acid metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism Z1_02977 yhhW_1 ko:K06911 Belongs to the pirin family NA Z1_02979 yflS_1 ko:K03319,ko:K14445 Sodium:sulfate symporter transmembrane region NA Z1_02981 ko05133,map05133 ko:K07345 Fimbrial protein Pertussis : Infectious disease: bacterial : Human Diseases Z1_02984 ko:K07349 Fimbrial protein NA Z1_02985 ko05133,map05133 ko:K07347 PapC C-terminal domain Pertussis : Infectious disease: bacterial : Human Diseases Z1_02986 ko:K07346,ko:K12519 Pili and flagellar-assembly chaperone, PapD N-terminal domain NA Z1_02987 ko05133,map05133 ko:K07345 Fimbrial protein Pertussis : Infectious disease: bacterial : Human Diseases Z1_02988 yfeX ko:K07223 Dyp-type peroxidase family NA Z1_02990 ko:K12521 Residues 11 to 176 of 176 are 92.81 pct identical to residues 1 to 167 of 167 from SwissProt.40 sp P42187 PRSF_ECOLI MINOR FIMBRIAL PROTEIN PRSF PRECURSOR NA Z1_02991 ko:K12523 Fimbrial protein NA Z1_02993 papD ko:K07346,ko:K12519 Pili assembly chaperone PapD, C-terminal domain NA Z1_02995 ko05133,map05133 ko:K07345,ko:K12517 cell adhesion Pertussis : Infectious disease: bacterial : Human Diseases Z1_02996 ko05133,map05133 ko:K07345,ko:K12517 fimbria a protein Pertussis : Infectious disease: bacterial : Human Diseases Z1_02998 ko00440,map00440 ko:K07053,ko:K20859 3.1.3.97,3.1.4.57 DNA polymerase alpha chain like domain Phosphonate and phosphinate metabolism : Metabolism of other amino acids : Metabolism Z1_03000 licT ko:K02538,ko:K03488 CAT RNA binding domain NA Z1_03001 yjaB ko:K03827 Acetyltransferase (GNAT) domain NA Z1_03002 mutS ko03430,map03430 ko:K03555 DNA mismatch repair protein Mismatch repair : Replication and repair : Genetic Information Processing Z1_03003 rpoS ko02026,ko05111,map02026,map05111 ko:K03087 Sigma-70 region 3 Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes Z1_03004 nlpD ko:K06194,ko:K12943 Lysin motif NA Z1_03005 pcm ko:K00573 2.1.1.77 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins NA Z1_03006 surE ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 ko:K03787 3.1.3.5 Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'- monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain- length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_03008 ispF ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 ko:K00554,ko:K00991,ko:K01770,ko:K12506 2.1.1.228,2.7.7.60,4.6.1.12 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) Terpenoid backbone biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA Z1_03009 ispD ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 ko:K00991 2.7.7.60 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) Terpenoid backbone biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA Z1_03010 ftsB ko:K05589 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic NA Z1_03011 cysC ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120 ko:K00860 2.7.1.25 Adenylylsulphate kinase Purine metabolism : Nucleotide metabolism : Metabolism;Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_03012 cysN ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 ko:K00955,ko:K00956 2.7.1.25,2.7.7.4 Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily Purine metabolism : Nucleotide metabolism : Metabolism;Monobactam biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA Z1_03013 cysD ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 ko:K00390,ko:K00957 1.8.4.10,1.8.4.8,2.7.7.4 Phosphoadenosine phosphosulfate reductase family Purine metabolism : Nucleotide metabolism : Metabolism;Monobactam biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA Z1_03014 cysG ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 ko:K02302,ko:K02303,ko:K02304,ko:K03795,ko:K13541,ko:K13542 1.3.1.76,2.1.1.107,2.1.1.131,3.7.1.12,4.2.1.75,4.99.1.3,4.99.1.4 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_03015 cysH ko00920,ko01100,ko01120,map00920,map01100,map01120 ko:K00390 1.8.4.10,1.8.4.8 Belongs to the PAPS reductase family. CysH subfamily Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_03016 cysI ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120 ko:K00366,ko:K00381,ko:K00392 1.7.7.1,1.8.1.2,1.8.7.1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate Nitrogen metabolism : Energy metabolism : Metabolism;Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_03017 cysJ ko00920,ko01100,ko01120,map00920,map01100,map01120 ko:K00380 1.8.1.2 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component Sulfur metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_03018 queD ko00790,ko01100,map00790,map01100 ko:K01737 4.1.2.50,4.2.3.12 6-pyruvoyl tetrahydropterin synthase Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_03019 queE ko00790,ko01100,map00790,map01100 ko:K04068,ko:K10026 1.97.1.4,4.3.99.3 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_03023 ko00920,map00920 ko:K17218 1.8.5.4 oxidoreductase Sulfur metabolism : Energy metabolism : Metabolism Z1_03030 rlmD ko03013,map03013 ko:K03215,ko:K06969,ko:K14292 2.1.1.190,2.1.1.191 Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA RNA transport : Translation : Genetic Information Processing Z1_03033 ko03030,ko03430,ko03440,map03030,map03430,map03440 ko:K03111 ERF superfamily DNA replication : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing Z1_03034 ssb ko03030,ko03430,ko03440,map03030,map03430,map03440 ko:K03111 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism DNA replication : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing Z1_03041 ko:K21039 Phage integrase family NA Z1_03042 nagE ko00010,ko00500,ko00520,ko02026,ko02060,ko05111,map00010,map00500,map00520,map02026,map02060,map05111 ko:K02755,ko:K02756,ko:K02757,ko:K02777,ko:K02778,ko:K02779,ko:K02790,ko:K02791,ko:K02802,ko:K02803,ko:K02804,ko:K02809,ko:K02810,ko:K02818,ko:K02819,ko:K20107,ko:K20108,ko:K20116,ko:K20117,ko:K20118 2.7.1.193,2.7.1.199,2.7.1.201,2.7.1.208,2.7.1.211 PTS system, N-acetylglucosamine-specific Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes Z1_03043 nagB ko00030,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00520,map01100,map01110,map01120,map01130,map01200 ko:K01057,ko:K02564 3.1.1.31,3.5.99.6 Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism Z1_03044 nagA ko00520,ko01130,map00520,map01130 ko:K01443 3.5.1.25 Belongs to the metallo-dependent hydrolases superfamily. NagA family Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;NA : NA : NA Z1_03045 nagC ko01059,ko01130,map01059,map01130 ko:K02003,ko:K02565,ko:K04096,ko:K07058,ko:K09720,ko:K15545,ko:K20421 2.1.1.303 ROK family Biosynthesis of enediyne antibiotics : Metabolism of terpenoids and polyketides : Metabolism;NA : NA : NA Z1_03053 frmR ko:K21600 Metal-sensitive transcriptional repressor NA Z1_03054 adhC ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204 ko:K00121 1.1.1.1,1.1.1.284 alcohol dehydrogenase class III (glutathione-dependent formaldehyde dehydrogenase) (FDH) (FALDH) K00001 K00121 Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Fatty acid degradation : Lipid metabolism : Metabolism;Tyrosine metabolism : Amino acid metabolism : Metabolism;Chloroalkane and chloroalkene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Naphthalene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Retinol metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolism of xenobiotics by cytochrome P450 : Xenobiotics biodegradation and metabolism : Metabolism;Drug metabolism - cytochrome P450 : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Degradation of aromatic compounds : Global and overview maps : Metabolism;Chemical carcinogenesis : Cancer: overview : Human Diseases Z1_03055 fghA ko00680,ko01120,ko01200,map00680,map01120,map01200 ko:K01070,ko:K09795 3.1.2.12 S-formylglutathione hydrolase Methane metabolism : Energy metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism Z1_03056 ubiF ko00130,ko01100,ko01110,map00130,map01100,map01110 ko:K03184,ko:K03185,ko:K18800 FAD binding domain Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_03057 miaB ko:K06168 2.8.4.3 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine NA Z1_03058 ybeZ ko:K06217 PhoH-like protein NA Z1_03059 ybeY ko00240,ko00750,ko00983,ko01100,map00240,map00750,map00983,map01100 ko:K01489,ko:K03474,ko:K03595,ko:K07042 2.6.99.2,3.5.4.5 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Vitamin B6 metabolism : Metabolism of cofactors and vitamins : Metabolism;Drug metabolism - other enzymes : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_03061 lnt ko:K03820 Transfers the fatty acyl group on membrane lipoproteins NA Z1_03063 scsD ko04621,ko05418,map04621,map05418 ko:K03671 Thioredoxin-like NOD-like receptor signaling pathway : Immune system : Organismal Systems;Fluid shear stress and atherosclerosis : Cardiovascular disease : Human Diseases Z1_03064 bdbD ko:K08344 DSBA-like thioredoxin domain NA Z1_03065 dsbD ko:K04084,ko:K08344 1.8.1.8 Disulphide bond corrector protein DsbC NA Z1_03067 gltI ko02010,ko02020,map02010,map02020 ko:K10001 Bacterial periplasmic substrate-binding proteins ABC transporters : Membrane transport : Environmental Information Processing;Two-component system : Signal transduction : Environmental Information Processing Z1_03068 gltJ ko02010,ko02020,map02010,map02020 ko:K02029,ko:K10003,ko:K10040 3-TM region, His Glu Gln Arg opine family ABC transporters : Membrane transport : Environmental Information Processing;Two-component system : Signal transduction : Environmental Information Processing Z1_03069 gltK ko02010,ko02020,map02010,map02020 ko:K02029,ko:K10002 Binding-protein-dependent transport system inner membrane component ABC transporters : Membrane transport : Environmental Information Processing;Two-component system : Signal transduction : Environmental Information Processing Z1_03070 gltL ko02010,ko02020,map02010,map02020 ko:K02028,ko:K10004 3.6.3.21 (ABC) transporter ABC transporters : Membrane transport : Environmental Information Processing;Two-component system : Signal transduction : Environmental Information Processing Z1_03071 leuS ko00970,map00970 ko:K01869 6.1.1.4 leucine-tRNA synthetase (leucine--tRNA ligase) (LEURS) K01869 Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing Z1_03072 lptE ko:K03643 Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane NA Z1_03073 holA ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 ko:K02340 2.7.7.7 DNA polymerase III, delta subunit Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;DNA replication : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing Z1_03074 nadD ko00230,ko00760,ko01100,ko05340,map00230,map00760,map01100,map05340 ko:K00969,ko:K01488,ko:K03574 2.7.7.18,3.5.4.4,3.6.1.55 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) Purine metabolism : Nucleotide metabolism : Metabolism;Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Primary immunodeficiency : Immune disease : Human Diseases Z1_03076 rsfS ko00760,ko01100,map00760,map01100 ko:K00969,ko:K09710 2.7.7.18 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_03077 rlmH ko:K00783 2.1.1.177 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA NA Z1_03078 mrdA ko00550,ko01501,map00550,map01501 ko:K05515 3.4.16.4 Catalyzes cross-linking of the peptidoglycan cell wall Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases Z1_03079 mrdB ko:K05837 Peptidoglycan polymerase that is essential for cell wall elongation NA Z1_03080 rlpA ko:K03642,ko:K03749 Lytic transglycolase NA Z1_03081 dacA ko00550,ko01100,map00550,map01100 ko:K07258 3.4.16.4 Penicillin-binding protein 5, C-terminal domain Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_03082 ybeD ko:K09158 Protein of unknown function (DUF493) NA Z1_03083 lipB ko00785,ko01100,map00785,map01100 ko:K03801 2.3.1.181 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate Lipoic acid metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_03084 lipA ko00785,ko01100,map00785,map01100 ko:K03644 2.8.1.8 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives Lipoic acid metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_03085 crcB ko:K06199 Important for reducing fluoride concentration in the cell, thus reducing its toxicity NA Z1_03087 cspE ko:K03704 Cold shock protein domain NA Z1_03088 ogt ko:K00567,ko:K10778 2.1.1.63 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated NA Z1_03089 nrdH ko:K06191 Glutaredoxin NA Z1_03090 nrdI ko:K03647 Probably involved in ribonucleotide reductase function NA Z1_03091 nrdE ko00230,ko00240,ko01100,map00230,map00240,map01100 ko:K00525 1.17.4.1 ribonucleoside-diphosphate reductase Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_03093 proV ko02010,map02010 ko:K02000 3.6.3.32 ATPases associated with a variety of cellular activities ABC transporters : Membrane transport : Environmental Information Processing Z1_03094 proW ko02010,map02010 ko:K02001,ko:K02002 ABC-type proline glycine betaine transport system, permease component ABC transporters : Membrane transport : Environmental Information Processing Z1_03096 tdhA ko:K02014,ko:K16087 TonB dependent receptor NA Z1_03098 mprA ko:K15974 helix_turn_helix multiple antibiotic resistance protein NA Z1_03100 mdtG ko:K05820,ko:K08161 MFS_1 like family NA Z1_03102 emrA ko:K03543 multidrug resistance efflux pump NA Z1_03103 emrB ko:K03446 Major Facilitator Superfamily NA Z1_03104 yfiF ko:K00556,ko:K03214,ko:K03218 2.1.1.185,2.1.1.34 RNA 2'-O ribose methyltransferase substrate binding NA Z1_03105 ko:K18015 NA Z1_03106 yfiP ko:K05812 DTW NA Z1_03107 yfiQ ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120 ko:K01905,ko:K09181,ko:K22224 6.2.1.13 CoA binding domain Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_03108 pssA ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 ko:K00998,ko:K06131 2.7.8.8 Phospholipase D. Active site motifs. Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_03109 yfiM ko:K05811 Predicted periplasmic lipoprotein (DUF2279) NA Z1_03113 ko:K07346,ko:K12519 Pili assembly chaperone PapD, C-terminal domain NA Z1_03116 ko:K07346,ko:K12519 Pili and flagellar-assembly chaperone, PapD N-terminal domain NA Z1_03117 ko:K07346,ko:K12519 Pili and flagellar-assembly chaperone, PapD N-terminal domain NA Z1_03118 fimD_3 ko05133,map05133 ko:K07347 Psort location OuterMembrane, score Pertussis : Infectious disease: bacterial : Human Diseases Z1_03120 kamA ko00310,map00310 ko:K01843,ko:K19810 5.4.3.2 lysine 2,3-aminomutase Lysine degradation : Amino acid metabolism : Metabolism Z1_03121 efp ko:K02356 Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation NA Z1_03122 rpiB ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 ko:K01808 5.3.1.6 Sugar-phosphate isomerase, RpiB LacA LacB family Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_03124 hyfB ko:K12137 Proton-conducting membrane transporter NA Z1_03125 hyfC ko:K12138,ko:K12139 NADH dehydrogenase NA Z1_03126 ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012 ko:K03883 1.6.5.3 Proton-conducting membrane transporter Oxidative phosphorylation : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Thermogenesis : Environmental adaptation : Organismal Systems;Retrograde endocannabinoid signaling : Nervous system : Organismal Systems;Parkinson disease : Neurodegenerative disease : Human Diseases Z1_03127 hyfE ko:K12140 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L NA Z1_03128 hyfF ko:K12141 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus NA Z1_03129 hyfG ko:K12142,ko:K15830 Nickel-dependent hydrogenase NA Z1_03130 hyfH ko:K12143,ko:K15831 4Fe-4S binding domain NA Z1_03132 hyfJ ko:K12145,ko:K15834 Formate hydrogenlyase maturation protein HycH NA Z1_03133 hycI ko00680,ko01100,ko01120,map00680,map01100,map01120 ko:K00442,ko:K03605,ko:K08315 3.4.23.51 Hydrogenase maturation protease Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_03134 yibD ko:K19354 Glycosyltransferase like family 2 NA Z1_03135 appA_2 ko02024,map02024 ko:K02035 Bacterial extracellular solute-binding proteins, family 5 Middle Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_03136 dppB ko02024,map02024 ko:K02033 Binding-protein-dependent transport system inner membrane component Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_03137 dppC ko01501,ko02010,ko02024,map01501,map02010,map02024 ko:K02031,ko:K02034,ko:K12370,ko:K15582,ko:K15586 ABC transporter (permease) beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_03138 oppD ko01501,ko02010,ko02024,map01501,map02010,map02024 ko:K02031,ko:K02032,ko:K15583 ATPases associated with a variety of cellular activities beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases;ABC transporters : Membrane transport : Environmental Information Processing;Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_03139 dppF ko02024,map02024 ko:K02032,ko:K10826 3.6.3.30 ATPases associated with a variety of cellular activities Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_03140 CP_1076 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 ko:K05349,ko:K21449 3.2.1.21 Autotransporter beta-domain Cyanoamino acid metabolism : Metabolism of other amino acids : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Phenylpropanoid biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_03141 yjjW ko:K04069 1.97.1.4 radical SAM domain protein NA Z1_03143 smp ko00500,ko00785,ko01100,ko02020,ko02025,map00500,map00785,map01100,map02020,map02025 ko:K00697,ko:K03800,ko:K07186,ko:K20973 2.4.1.15,2.4.1.347,2.7.13.3,6.3.1.20 Bacterial virulence factor haemolysin Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Lipoic acid metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes Z1_03144 serB ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 ko:K01079 3.1.3.3 phosphoserine phosphatase Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_03145 radA ko:K04485 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function NA Z1_03146 nadR ko00760,ko00770,ko01100,map00760,map00770,map01100 ko:K00954,ko:K06211 2.7.1.22,2.7.7.1,2.7.7.3 AAA domain Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_03147 bscC ko02025,map02025 ko:K02200,ko:K04018,ko:K19225,ko:K20543,ko:K21007 3.4.21.105 DUF218 domain Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes Z1_03148 fes ko:K07214 esterase NA Z1_03149 phoA ko00521,ko00730,ko00790,ko01100,ko01130,ko02020,map00521,map00730,map00790,map01100,map01130,map02020 ko:K01077,ko:K04342 3.1.3.1,3.1.3.39 alkaline phosphatase precursor (APASE) K01077 Streptomycin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Thiamine metabolism : Metabolism of cofactors and vitamins : Metabolism;Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;NA : NA : NA;Two-component system : Signal transduction : Environmental Information Processing Z1_03150 yjbB ko:K03324 Na+/Pi-cotransporter NA Z1_03155 rsmC ko:K00564 2.1.1.172 Ribosomal RNA small subunit methyltransferase C NA Z1_03156 holD ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 ko:K02344 2.7.7.7 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;DNA replication : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing Z1_03157 rimI ko:K01409,ko:K03789,ko:K14742 2.3.1.128,2.3.1.234 of ribosomal protein S18 NA Z1_03163 ko:K18481,ko:K18640 PRTRC system protein D NA Z1_03165 umuC ko:K02346,ko:K03502 2.7.7.7 COG0389 Nucleotidyltransferase DNA polymerase involved in DNA repair NA Z1_03168 ko:K07729 Helix-turn-helix XRE-family like proteins NA Z1_03174 clpP ko04112,ko04212,map04112,map04212 ko:K01358 3.4.21.92 clp protease Cell cycle - Caulobacter : Cell growth and death : Cellular Processes;Longevity regulating pathway - worm : Aging : Organismal Systems Z1_03178 ko03030,ko03430,ko03440,map03030,map03430,map03440 ko:K03111 ERF superfamily DNA replication : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing Z1_03179 ssb ko03030,ko03430,ko03440,map03030,map03430,map03440 ko:K03111 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism DNA replication : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing Z1_03182 icd ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 ko:K00031 1.1.1.42 Isocitrate/isopropylmalate dehydrogenase Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Glutathione metabolism : Metabolism of other amino acids : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism;Peroxisome : Transport and catabolism : Cellular Processes Z1_03183 rluE ko:K06178,ko:K06181,ko:K06183 5.4.99.19,5.4.99.20,5.4.99.22 RNA pseudouridylate synthase NA Z1_03184 nudJ ko:K03574,ko:K12152 3.6.1.55 NUDIX domain NA Z1_03185 mnmA ko04122,map04122 ko:K00566 2.8.1.13 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis. Sulfur is provided by IscS, via a sulfur-relay system. Binds ATP and its substrate tRNAs Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing Z1_03186 hflD ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 ko:K01756,ko:K07153 4.3.2.2 Protein of unknown function (DUF489) Purine metabolism : Nucleotide metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA Z1_03187 purB ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 ko:K01756 4.3.2.2 Adenylosuccinate lyase C-terminal Purine metabolism : Nucleotide metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA Z1_03190 ycfD ko:K18850 1.14.11.47 A domain family that is part of the cupin metalloenzyme superfamily. NA Z1_03192 pepT ko:K01258 3.4.11.4 peptidase NA Z1_03193 cobB ko:K12410 NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form NA Z1_03194 lolE ko02010,map02010 ko:K02004,ko:K09808 MacB-like periplasmic core domain ABC transporters : Membrane transport : Environmental Information Processing Z1_03195 lolD ko02010,map02010 ko:K09810 Part of the ABC transporter complex LolCDE involved in the translocation of ABC transporters : Membrane transport : Environmental Information Processing Z1_03196 lolC ko02010,map02010 ko:K02004,ko:K09808 Lipoprotein releasing system transmembrane protein ABC transporters : Membrane transport : Environmental Information Processing Z1_03197 mfd ko03420,map03420 ko:K03723 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site Nucleotide excision repair : Replication and repair : Genetic Information Processing Z1_03199 ndh ko00190,map00190 ko:K03885 1.6.99.3 Pyridine nucleotide-disulphide oxidoreductase Oxidative phosphorylation : Energy metabolism : Metabolism Z1_03200 ycfP ko:K07000 Uncharacterised protein family (UPF0227) NA Z1_03201 nagZ ko00460,ko00500,ko00520,ko00531,ko00770,ko00940,ko01100,ko01110,ko01501,map00460,map00500,map00520,map00531,map00770,map00940,map01100,map01110,map01501 ko:K00997,ko:K01207,ko:K05349 2.7.8.7,3.2.1.21,3.2.1.52 Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides Cyanoamino acid metabolism : Metabolism of other amino acids : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Glycosaminoglycan degradation : Glycan biosynthesis and metabolism : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Phenylpropanoid biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases Z1_03202 thiK ko00730,ko01100,map00730,map01100 ko:K07251 2.7.1.89 Catalyzes the phosphorylation of thiamine to thiamine phosphate Thiamine metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_03203 lpoB ko02025,map02025 ko:K07337,ko:K21008 Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes Z1_03205 hinT ko:K02503 HIT domain NA Z1_03206 ycfH ko:K03424 TatD related DNase NA Z1_03207 holB ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 ko:K02341 2.7.7.7 DNA polymerase III, delta subunit, C terminal Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;DNA replication : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing Z1_03208 tmk ko00240,ko01100,map00240,map01100 ko:K00943 2.7.4.9 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_03209 mltG ko:K07082 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation NA Z1_03210 pabC ko00270,ko00280,ko00290,ko00770,ko00790,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map00790,map01100,map01110,map01130,map01210,map01230 ko:K00826,ko:K02619 2.6.1.42,4.1.3.38 Amino-transferase class IV Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Valine, leucine and isoleucine degradation : Amino acid metabolism : Metabolism;Valine, leucine and isoleucine biosynthesis : Amino acid metabolism : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_03211 fabF ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 ko:K09458 2.3.1.179 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP Fatty acid biosynthesis : Lipid metabolism : Metabolism;Biotin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism Z1_03212 acpP ko:K02078 Carrier of the growing fatty acid chain in fatty acid biosynthesis NA Z1_03214 fabD ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 ko:K00645 2.3.1.39 Acyl transferase domain Fatty acid biosynthesis : Lipid metabolism : Metabolism;Prodigiosin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;NA : NA : NA;Fatty acid metabolism : Global and overview maps : Metabolism Z1_03215 fabH ko00061,ko01100,ko01212,map00061,map01100,map01212 ko:K00648 2.3.1.180 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids Fatty acid biosynthesis : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism Z1_03216 plsX ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 ko:K03621 2.3.1.15 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA Glycerolipid metabolism : Lipid metabolism : Metabolism;Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_03217 rpmF ko03010,map03010 ko:K02911 Belongs to the bacterial ribosomal protein bL32 family Ribosome : Translation : Genetic Information Processing Z1_03218 yceD ko:K07040 Uncharacterized ACR, COG1399 NA Z1_03219 maf ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 ko:K00014,ko:K03215,ko:K06287 1.1.1.25,2.1.1.190 Maf-like protein Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_03221 rluC ko:K06179 5.4.99.24 Pseudouridine synthase NA Z1_03222 rne ko03018,map03018 ko:K08300 3.1.26.12 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs RNA degradation : Folding, sorting and degradation : Genetic Information Processing Z1_03223 yeeX ko:K09802 Protein of unknown function (DUF496) NA Z1_03224 lacY ko:K02532,ko:K08167 Major facilitator superfamily NA Z1_03225 fosB ko:K11210,ko:K21265 2.5.1.18 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily NA Z1_03226 sbcB ko03430,map03430 ko:K01141 3.1.11.1 exodeoxyribonuclease I (exonuclease I) (DNA deoxyribophosphodiesterase) K01141 Mismatch repair : Replication and repair : Genetic Information Processing Z1_03227 dld ko00620,ko01120,map00620,map01120 ko:K03777 1.1.5.12 D-lactate dehydrogenase Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_03229 ipdC ko00380,ko01100,map00380,map01100 ko:K04103 4.1.1.74 Thiamine pyrophosphate enzyme Tryptophan metabolism : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_03233 yifE ko:K09897 Protein of unknown function, DUF NA Z1_03234 comM ko:K07391 Magnesium chelatase, subunit ChlI NA Z1_03236 ilvG ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 ko:K01652 2.2.1.6 acetolactate synthase Valine, leucine and isoleucine biosynthesis : Amino acid metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;C5-Branched dibasic acid metabolism : Carbohydrate metabolism : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_03237 ilvM ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 ko:K01653,ko:K11258 2.2.1.6 ACT domain Valine, leucine and isoleucine biosynthesis : Amino acid metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;C5-Branched dibasic acid metabolism : Carbohydrate metabolism : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_03238 ilvE ko00270,ko00280,ko00290,ko00310,ko00330,ko00360,ko00472,ko00473,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00310,map00330,map00360,map00472,map00473,map00770,map01100,map01110,map01130,map01210,map01230 ko:K00824,ko:K00826 2.6.1.21,2.6.1.42 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Valine, leucine and isoleucine degradation : Amino acid metabolism : Metabolism;Valine, leucine and isoleucine biosynthesis : Amino acid metabolism : Metabolism;Lysine degradation : Amino acid metabolism : Metabolism;Arginine and proline metabolism : Amino acid metabolism : Metabolism;Phenylalanine metabolism : Amino acid metabolism : Metabolism;D-Arginine and D-ornithine metabolism : Metabolism of other amino acids : Metabolism;D-Alanine metabolism : Metabolism of other amino acids : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_03239 ilvD ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 ko:K01687 4.2.1.9 Belongs to the IlvD Edd family Valine, leucine and isoleucine biosynthesis : Amino acid metabolism : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_03240 ilvA ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 ko:K01754 4.3.1.19 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA Glycine, serine and threonine metabolism : Amino acid metabolism : Metabolism;Valine, leucine and isoleucine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_03241 ilvY ko:K02521 Bacterial regulatory helix-turn-helix protein, lysR family NA Z1_03243 yafQ ko:K19157 ParE toxin of type II toxin-antitoxin system, parDE NA Z1_03245 rep ko03420,ko03430,map03420,map03430 ko:K03656,ko:K03657 3.6.4.12 it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction Nucleotide excision repair : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing Z1_03246 gppA ko00230,map00230 ko:K01524 3.6.1.11,3.6.1.40 Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the stringent response , an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities Purine metabolism : Nucleotide metabolism : Metabolism Z1_03247 rhlB ko03018,map03018 ko:K03732 3.6.4.13 Belongs to the DEAD box helicase family RNA degradation : Folding, sorting and degradation : Genetic Information Processing Z1_03248 trxA ko04621,ko05418,map04621,map05418 ko:K03671 Thioredoxin NOD-like receptor signaling pathway : Immune system : Organismal Systems;Fluid shear stress and atherosclerosis : Cardiovascular disease : Human Diseases Z1_03249 rho ko03010,ko03018,map03010,map03018 ko:K02887,ko:K03628 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template Ribosome : Translation : Genetic Information Processing;RNA degradation : Folding, sorting and degradation : Genetic Information Processing Z1_03250 wecA ko00520,ko01100,ko05111,map00520,map01100,map05111 ko:K01791,ko:K02851 2.7.8.33,2.7.8.35,5.1.3.14 Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55) Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes Z1_03251 wzzE ko:K05789,ko:K05790 Modulates the polysaccharide chain length of enterobacterial common antigen (ECA) NA Z1_03252 wecB ko00520,ko01100,ko05111,map00520,map01100,map05111 ko:K01791 5.1.3.14 Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes Z1_03253 wecC ko00520,ko05111,map00520,map05111 ko:K02472,ko:K02474 1.1.1.336 Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD( ) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes Z1_03255 rfbA ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 ko:K00973 2.7.7.24 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis Streptomycin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;Polyketide sugar unit biosynthesis : Metabolism of terpenoids and polyketides : Metabolism;Acarbose and validamycin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;NA : NA : NA Z1_03256 wecD ko:K16704 2.3.1.210 Catalyzes the acetylation of dTDP-fucosamine (dTDP-4- amino-4,6-dideoxy-D-galactose) to dTDP-Fuc4NAc, which is utilized in the biosynthesis of the enterobacterial common antigen (ECA) NA Z1_03258 wzxE ko:K03328,ko:K16693 Mediates the transbilayer movement of Und-PP-GlcNAc- ManNAcA-Fuc4NAc (lipid III) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of enterobacterial common antigen (ECA) NA Z1_03259 rffT ko:K02853,ko:K12582 2.4.1.325 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis NA Z1_03260 wzyE ko:K02853 Probably involved in the polymerization of enterobacterial common antigen (ECA) trisaccharide repeat units NA Z1_03261 rffM ko05111,map05111 ko:K02852,ko:K05946 2.4.1.180,2.4.1.187 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes Z1_03267 hemY ko:K02498 HemY protein N-terminus NA Z1_03269 hemD ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 ko:K01719,ko:K01749,ko:K02496,ko:K13542,ko:K13543 2.1.1.107,2.5.1.61,4.2.1.75 Uroporphyrinogen-III synthase HemD Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_03270 hemC ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 ko:K01749,ko:K13542 2.1.1.107,2.5.1.61,4.2.1.75 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_03271 cyaA ko00230,ko02026,ko05111,map00230,map02026,map05111 ko:K05851 4.6.1.1 adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase) K05851 Purine metabolism : Nucleotide metabolism : Metabolism;Biofilm formation - Escherichia coli : Cellular community - prokaryotes : Cellular Processes;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes Z1_03272 cyaY ko00860,map00860 ko:K06202,ko:K19054 1.16.3.1 Frataxin-like domain Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism Z1_03273 dapF ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 ko:K01778 5.1.1.7 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine Lysine biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_03274 yigA ko:K09921 Protein of unknown function, DUF484 NA Z1_03275 xerC ko:K03733 Phage integrase, N-terminal SAM-like domain NA Z1_03276 yigB ko00010,ko00740,ko01100,ko01110,ko01120,map00010,map00740,map01100,map01110,map01120 ko:K07025,ko:K20862,ko:K20866 3.1.3.10,3.1.3.102,3.1.3.104 Hydrolase Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Riboflavin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_03277 uvrD ko03420,ko03430,map03420,map03430 ko:K03656,ko:K03657 3.6.4.12 DNA helicase Nucleotide excision repair : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing Z1_03279 rarD ko:K05786 EamA-like transporter family NA Z1_03281 pldA ko00564,ko00565,ko00590,ko00591,ko00592,ko01100,ko01110,map00564,map00565,map00590,map00591,map00592,map01100,map01110 ko:K01058 3.1.1.32,3.1.1.4 Phospholipase A1 Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Ether lipid metabolism : Lipid metabolism : Metabolism;Arachidonic acid metabolism : Lipid metabolism : Metabolism;Linoleic acid metabolism : Lipid metabolism : Metabolism;alpha-Linolenic acid metabolism : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_03282 recQ ko03018,map03018 ko:K03654 3.6.4.12 RQC RNA degradation : Folding, sorting and degradation : Genetic Information Processing Z1_03283 pldB ko00564,map00564 ko:K01048 3.1.1.5 Serine aminopeptidase, S33 Glycerophospholipid metabolism : Lipid metabolism : Metabolism Z1_03285 Z012_11195 ko:K07496 Transposase NA Z1_03286 hemG ko00860,ko01100,ko01110,map00860,map01100,map01110 ko:K00230 1.3.5.3 Flavodoxin domain Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_03287 trkH ko:K03498,ko:K03499 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA NA Z1_03288 yigZ ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 ko:K00560,ko:K01271 2.1.1.45,3.4.13.9 Domain of unknown function (DUF1949) Pyrimidine metabolism : Nucleotide metabolism : Metabolism;One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Antifolate resistance : Drug resistance: antineoplastic : Human Diseases Z1_03289 pepQ ko:K01262,ko:K01271 3.4.11.9,3.4.13.9 Splits dipeptides with a prolyl residue in the C- terminal position NA Z1_03290 fadB ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 ko:K01782,ko:K01825 1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8 Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate Fatty acid degradation : Lipid metabolism : Metabolism;Valine, leucine and isoleucine degradation : Amino acid metabolism : Metabolism;Geraniol degradation : Metabolism of terpenoids and polyketides : Metabolism;Lysine degradation : Amino acid metabolism : Metabolism;Benzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Tryptophan metabolism : Amino acid metabolism : Metabolism;beta-Alanine metabolism : Metabolism of other amino acids : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Limonene and pinene degradation : Metabolism of terpenoids and polyketides : Metabolism;Caprolactam degradation : Xenobiotics biodegradation and metabolism : Metabolism;Biosynthesis of unsaturated fatty acids : Lipid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism Z1_03291 fadA ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212 ko:K00632 2.3.1.16 Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed Fatty acid degradation : Lipid metabolism : Metabolism;Valine, leucine and isoleucine degradation : Amino acid metabolism : Metabolism;Geraniol degradation : Metabolism of terpenoids and polyketides : Metabolism;Benzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;alpha-Linolenic acid metabolism : Lipid metabolism : Metabolism;Ethylbenzene degradation : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Fatty acid metabolism : Global and overview maps : Metabolism Z1_03292 fre ko00240,ko00520,ko00627,ko00740,ko00860,ko01100,ko01120,ko02024,map00240,map00520,map00627,map00740,map00860,map01100,map01120,map02024 ko:K00523,ko:K02823,ko:K05368,ko:K18248,ko:K20256 1.16.1.3,1.17.1.1,1.5.1.41 COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Aminobenzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Riboflavin metabolism : Metabolism of cofactors and vitamins : Metabolism;Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Quorum sensing : Cellular community - prokaryotes : Cellular Processes Z1_03293 ubiD ko00130,ko00627,ko01100,ko01110,ko01120,map00130,map00627,map01100,map01110,map01120 ko:K03182,ko:K16239 4.1.1.61,4.1.1.98 Belongs to the UbiD family Ubiquinone and other terpenoid-quinone biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Aminobenzoate degradation : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism Z1_03294 pepE ko:K05995 3.4.13.21 Peptidase family S51 NA Z1_03295 rfaH ko:K02601,ko:K05785 Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components. RfaH is recruited into a multi-component RNA polymerase complex by the ops element, which is a short conserved DNA sequence located downstream of the main promoter of these operons. Once bound, RfaH suppresses pausing and inhibits Rho- dependent and intrinsic termination at a subset of sites. Termination signals are bypassed, which allows complete synthesis of long RNA chains NA Z1_03296 tatC ko03060,ko03070,map03060,map03070 ko:K03118 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides Protein export : Folding, sorting and degradation : Genetic Information Processing;Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_03297 tatB ko03060,ko03070,map03060,map03070 ko:K03116,ko:K03117 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation Protein export : Folding, sorting and degradation : Genetic Information Processing;Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_03298 tatA ko03060,ko03070,map03060,map03070 ko:K03116 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system Protein export : Folding, sorting and degradation : Genetic Information Processing;Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_03299 ubiB ko:K03688 Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis NA Z1_03300 yigP ko:K03690 SCP-2 sterol transfer family NA Z1_03302 rmuC ko:K09760 RmuC family NA Z1_03303 dedA ko00550,map00550 ko:K03975,ko:K19302 3.6.1.27 SNARE associated Golgi protein Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism Z1_03304 ko:K01104 3.1.3.48 Tyrosine phosphatase family NA Z1_03305 udp ko00240,ko00983,ko01100,map00240,map00983,map01100 ko:K00757 2.4.2.3 Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Drug metabolism - other enzymes : Xenobiotics biodegradation and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_03308 metE ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 ko:K00549 2.1.1.14 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation Cysteine and methionine metabolism : Amino acid metabolism : Metabolism;Selenocompound metabolism : Metabolism of other amino acids : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_03309 metR ko:K03576 Bacterial regulatory helix-turn-helix protein, lysR family NA Z1_03311 yjcE ko:K03316 NhaP-type Na H and K H antiporters NA Z1_03312 speG_2 ko:K03825 Acetyltransferase (GNAT) domain NA Z1_03313 pbuG ko:K06901 Permease family NA Z1_03318 ilvN ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 ko:K01653 2.2.1.6 ACT domain Valine, leucine and isoleucine biosynthesis : Amino acid metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;C5-Branched dibasic acid metabolism : Carbohydrate metabolism : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_03319 ilvB ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 ko:K01652 2.2.1.6 subunit K01652 Valine, leucine and isoleucine biosynthesis : Amino acid metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;C5-Branched dibasic acid metabolism : Carbohydrate metabolism : Metabolism;Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;2-Oxocarboxylic acid metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_03320 ko:K07090 Sulfite exporter TauE/SafE NA Z1_03321 ko:K15835,ko:K19337 Helix-turn-helix domain, rpiR family NA Z1_03322 ybbF ko00010,ko00500,ko00520,ko02060,ko05111,map00010,map00500,map00520,map02060,map05111 ko:K02755,ko:K02756,ko:K02757,ko:K02778,ko:K02779,ko:K02790,ko:K02791,ko:K02802,ko:K02803,ko:K02804,ko:K02809,ko:K02810,ko:K02818,ko:K02819 2.7.1.193,2.7.1.199,2.7.1.201,2.7.1.208,2.7.1.211 Phosphotransferase system, EIIC Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes Z1_03323 ko00030,map00030 ko:K00852 2.7.1.15 carbohydrate kinase activity Pentose phosphate pathway : Carbohydrate metabolism : Metabolism Z1_03324 rbsK ko00030,map00030 ko:K00852 2.7.1.15 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway Pentose phosphate pathway : Carbohydrate metabolism : Metabolism Z1_03325 ko00030,map00030 ko:K01619 4.1.2.4 deoxyribose-phosphate aldolase activity Pentose phosphate pathway : Carbohydrate metabolism : Metabolism Z1_03326 deoR ko:K11534 DeoR C terminal sensor domain NA Z1_03327 rtcB ko01501,map01501 ko:K14415,ko:K18148 6.5.1.3 tRNA-splicing ligase RtcB beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases Z1_03328 prfH ko:K02839 RF-1 domain NA Z1_03332 ko:K01150 3.1.21.1 Endonuclease I NA Z1_03333 ko:K06915 Domain of unknown function DUF87 NA Z1_03335 traN ko:K12058 Type-1V conjugative transfer system mating pair stabilisation NA Z1_03336 traU ko:K12060 PFAM TraU NA Z1_03337 traW ko:K12061 PFAM Type-F conjugative transfer system pilin assembly protein NA Z1_03338 ko:K12062 PFAM Peptidase S26 NA Z1_03340 traG ko:K12063 type-IV secretion system protein TraC NA Z1_03341 ko:K03981,ko:K12228 5.3.4.1 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process NA Z1_03342 ko:K09144 Nucleotidyl transferase AbiEii toxin, Type IV TA system NA Z1_03344 ko:K12069 NA Z1_03345 traV ko:K12064 PFAM Type IV conjugative transfer system NA Z1_03346 traB ko:K12065,ko:K15051 PFAM Bacterial conjugation TrbI-like protein NA Z1_03347 ko:K12066 PFAM TraK protein NA Z1_03348 traE ko:K12067 type IV conjugative transfer system protein TraE NA Z1_03349 ko:K12068 TIGRFAM type IV conjugative transfer system protein TraL NA Z1_03352 VP1577 ko:K12071 Domain of unknown function (DUF4400) NA Z1_03354 traD ko:K12071 TraM recognition site of TraD and TraG NA Z1_03355 ko:K03698,ko:K12070 Putative helicase NA Z1_03359 ko:K01156 3.1.21.5 Type III restriction enzyme, res subunit NA Z1_03360 mod ko:K07316 2.1.1.72 DNA methylase NA Z1_03361 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 ko:K02342 2.7.7.7 WYL domain Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;DNA replication : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing Z1_03363 polC ko00230,ko00240,ko01100,ko03030,ko03420,ko03430,ko03440,map00230,map00240,map01100,map03030,map03420,map03430,map03440 ko:K02342,ko:K03657,ko:K03763 2.7.7.7,3.6.4.12 Exonuclease Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;DNA replication : Replication and repair : Genetic Information Processing;Nucleotide excision repair : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing Z1_03364 umuD ko:K03503 COG1974 SOS-response transcriptional repressors (RecA-mediated autopeptidases) NA Z1_03365 ko:K04763 Belongs to the 'phage' integrase family NA Z1_03366 ko:K07497 PFAM Integrase, catalytic region NA Z1_03367 ko:K07483,ko:K07497 Transposase NA Z1_03370 ybgL ko:K07160 LamB/YcsF family NA Z1_03372 bccA ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212 ko:K11263 6.3.4.14,6.4.1.2,6.4.1.3 carboxylase Fatty acid biosynthesis : Lipid metabolism : Metabolism;Valine, leucine and isoleucine degradation : Amino acid metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Fatty acid metabolism : Global and overview maps : Metabolism Z1_03373 ko:K07090 Sulfite exporter TauE/SafE NA Z1_03376 ko:K10972 Bacterial regulatory helix-turn-helix protein, lysR family NA Z1_03377 narL ko02020,map02020 ko:K07684 helix_turn_helix, Lux Regulon Two-component system : Signal transduction : Environmental Information Processing Z1_03378 narX ko02020,map02020 ko:K07673,ko:K07674 2.7.13.3 Histidine kinase Two-component system : Signal transduction : Environmental Information Processing Z1_03379 narK ko00910,map00910 ko:K02575 nitrate nitrite transporter Nitrogen metabolism : Energy metabolism : Metabolism Z1_03380 narG ko00910,ko01120,ko02020,map00910,map01120,map02020 ko:K00370,ko:K17050 1.7.5.1 respiratory nitrate reductase 1 alpha chain K00370 Nitrogen metabolism : Energy metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing Z1_03381 narH ko00910,ko01120,ko02020,map00910,map01120,map02020 ko:K00371 1.7.5.1 respiratory nitrate reductase 1 beta chain K00371 Nitrogen metabolism : Energy metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing Z1_03382 narJ ko00910,ko01120,ko02020,map00910,map01120,map02020 ko:K00370,ko:K00373,ko:K17052 1.7.5.1 nitrate reductase molybdenum cofactor assembly chaperone Nitrogen metabolism : Energy metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing Z1_03383 narI ko00910,ko01120,ko02020,map00910,map01120,map02020 ko:K00370,ko:K00374,ko:K02575 1.7.5.1 Nitrate reductase gamma subunit Nitrogen metabolism : Energy metabolism : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing Z1_03384 lctO ko:K10530 FMN-dependent dehydrogenase NA Z1_03385 eptB ko00540,ko01503,map00540,map01503 ko:K03760,ko:K12975 2.7.8.42,2.7.8.43 membrane-associated metal-dependent hydrolase Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases Z1_03386 fdhF ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200 ko:K00123,ko:K05299,ko:K22015 1.17.1.10,1.17.1.9,1.17.99.7 formate dehydrogenase Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism Z1_03387 fdhF ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200 ko:K00123,ko:K05299,ko:K22015 1.17.1.10,1.17.1.9,1.17.99.7 formate dehydrogenase Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism Z1_03389 fhlA ko02020,ko02025,ko05132,map02020,map02025,map05132 ko:K02584,ko:K12146,ko:K12266,ko:K15836,ko:K21009 Domain present in phytochromes and cGMP-specific phosphodiesterases. Two-component system : Signal transduction : Environmental Information Processing;Biofilm formation - Pseudomonas aeruginosa : Cellular community - prokaryotes : Cellular Processes;Salmonella infection : Infectious disease: bacterial : Human Diseases Z1_03390 hydN ko:K05796,ko:K12136 4Fe-4S binding domain NA Z1_03391 hypA ko:K04651 Probably plays a role in a hydrogenase nickel cofactor insertion step NA Z1_03392 hypC ko:K04653 HupF/HypC family NA Z1_03393 sugE ko:K11741 Small Multidrug Resistance protein NA Z1_03394 frdD ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 ko:K00247 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Oxidative phosphorylation : Energy metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing Z1_03395 frdC ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 ko:K00246 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Oxidative phosphorylation : Energy metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing Z1_03396 frdB ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 ko:K00240,ko:K00245 1.3.5.1,1.3.5.4 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Oxidative phosphorylation : Energy metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing Z1_03397 frdA ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134 ko:K00239,ko:K00244 1.3.5.1,1.3.5.4 Fumarate reductase flavoprotein C-term Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Oxidative phosphorylation : Energy metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Butanoate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Two-component system : Signal transduction : Environmental Information Processing;Legionellosis : Infectious disease: bacterial : Human Diseases Z1_03398 epmA ko:K04568 With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P NA Z1_03399 glpQ ko00564,map00564 ko:K01126 3.1.4.46 Glycerophosphoryl diester phosphodiesterase family Glycerophospholipid metabolism : Lipid metabolism : Metabolism Z1_03400 glpT ko:K02445 Major Facilitator Superfamily NA Z1_03401 glpA ko00564,ko01110,map00564,map01110 ko:K00111 1.1.5.3 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_03402 glpB ko00564,ko01110,map00564,map01110 ko:K00112 1.1.5.3 Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_03403 glpC ko00564,ko01110,map00564,map01110 ko:K00113 1.1.5.3 anaerobic glycerol-3-phosphate dehydrogenase subunit C K00113 Glycerophospholipid metabolism : Lipid metabolism : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_03404 gldA ko00561,ko00640,ko01100,map00561,map00640,map01100 ko:K00005 1.1.1.6 Iron-containing alcohol dehydrogenase Glycerolipid metabolism : Lipid metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_03405 yhhQ ko:K09125 Involved in the import of queuosine (Q) precursors, required for Q precursor salvage NA Z1_03406 tusA ko04122,map04122 ko:K04085 Sulfur carrier protein involved in sulfur trafficking in the cell. Part of a sulfur-relay system required for 2-thiolation during synthesis of 2-thiouridine of the modified wobble base 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) in tRNA. Interacts with IscS and stimulates its cysteine desulfurase activity. Accepts an activated sulfur from IscS, which is then transferred to TusD, and thus determines the direction of sulfur flow from IscS to 2-thiouridine formation. Also appears to be involved in sulfur transfer for the biosynthesis of molybdopterin Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing Z1_03407 lutA ko:K18928 Cysteine-rich domain NA Z1_03408 lutB ko:K18929 Domain of unknown function (DUF3390) NA Z1_03409 lutC ko:K00782 LUD domain NA Z1_03410 yhbX ko00540,ko01503,map00540,map01503 ko:K03760,ko:K12975,ko:K19353 2.7.8.42,2.7.8.43 Sulfatase Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases Z1_03411 actP ko:K14393 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family NA Z1_03413 acsA ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 ko:K01895 6.2.1.1 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl- adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Propanoate metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism Z1_03414 sodA ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 ko:K04564 1.15.1.1 Destroys radicals which are normally produced within the cells and which are toxic to biological systems MAPK signaling pathway - fly : Signal transduction : Environmental Information Processing;FoxO signaling pathway : Signal transduction : Environmental Information Processing;Peroxisome : Transport and catabolism : Cellular Processes;Longevity regulating pathway : Aging : Organismal Systems;Longevity regulating pathway - worm : Aging : Organismal Systems;Longevity regulating pathway - multiple species : Aging : Organismal Systems;Huntington disease : Neurodegenerative disease : Human Diseases Z1_03416 trpS ko00970,map00970 ko:K01867 6.1.1.2 Tryptophanyl-tRNA synthetase Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing Z1_03417 gph ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 ko:K01091 3.1.3.18 phosphoglycolate phosphatase Glyoxylate and dicarboxylate metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA Z1_03418 rpe ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 ko:K01783 5.1.3.1 Ribulose-phosphate 3 epimerase family Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Pentose and glucuronate interconversions : Carbohydrate metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_03419 dam ko03430,map03430 ko:K06223 2.1.1.72 D12 class N6 adenine-specific DNA methyltransferase Mismatch repair : Replication and repair : Genetic Information Processing Z1_03420 damX ko:K03112 Cell division protein DamX NA Z1_03421 aroB ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 ko:K01735,ko:K13829 2.7.1.71,4.2.3.4 3-dehydroquinate synthase Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_03422 aroK ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 ko:K00891,ko:K13829 2.7.1.71,4.2.3.4 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_03423 pilQ ko:K02507,ko:K02666 Bacterial type II/III secretion system short domain NA Z1_03425 pilN ko:K02662,ko:K02663,ko:K12289 PFAM Fimbrial assembly family protein NA Z1_03426 hofM ko03070,ko05111,map03070,map05111 ko:K02461,ko:K02662,ko:K02663,ko:K12288 Pilus assembly protein Bacterial secretion system : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes Z1_03427 mrcA ko00550,ko01100,ko01501,map00550,map01100,map01501 ko:K05366 2.4.1.129,3.4.16.4 penicillin-binding protein 1A (PBP-1a) (PBP1a) (penicillin-binding protein A) includes penicillin-insensitive transglycosylase (peptidoglycan TGase) Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases Z1_03429 nudE ko00230,map00230 ko:K08312 NUDIX domain Purine metabolism : Nucleotide metabolism : Metabolism Z1_03431 hslR ko:K04762 S4 RNA-binding domain NA Z1_03432 hslO ko:K04083 Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress NA Z1_03433 pckA ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 ko:K01610 4.1.1.49 Belongs to the phosphoenolpyruvate carboxykinase (ATP) family Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Citrate cycle (TCA cycle) : Carbohydrate metabolism : Metabolism;Pyruvate metabolism : Carbohydrate metabolism : Metabolism;Carbon fixation in photosynthetic organisms : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism Z1_03434 yhhW ko:K06911 Pirin NA Z1_03437 yhiN ko:K07007 HI0933-like protein NA Z1_03444 recB ko03440,map03440 ko:K03582,ko:K16898 3.1.11.5,3.6.4.12 PDDEXK-like domain of unknown function (DUF3799) Homologous recombination : Replication and repair : Genetic Information Processing Z1_03446 ssb ko03030,ko03430,ko03440,map03030,map03430,map03440 ko:K03111 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism DNA replication : Replication and repair : Genetic Information Processing;Mismatch repair : Replication and repair : Genetic Information Processing;Homologous recombination : Replication and repair : Genetic Information Processing Z1_03460 folD ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 ko:K01491 1.5.1.5,3.5.4.9 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;Carbon fixation pathways in prokaryotes : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Carbon metabolism : Global and overview maps : Metabolism Z1_03461 yaaA ko:K14761 S4 domain NA Z1_03463 fruK ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230 ko:K00882,ko:K16370 2.7.1.11,2.7.1.56 belongs to the carbohydrate kinase PfkB family Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Pentose phosphate pathway : Carbohydrate metabolism : Metabolism;Fructose and mannose metabolism : Carbohydrate metabolism : Metabolism;Galactose metabolism : Carbohydrate metabolism : Metabolism;Methane metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;NA : NA : NA;Carbon metabolism : Global and overview maps : Metabolism;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_03465 ppiB ko01503,ko04217,map01503,map04217 ko:K03767,ko:K03768,ko:K08884 2.7.11.1,5.2.1.8 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases;Necroptosis : Cell growth and death : Cellular Processes Z1_03466 lpxH ko00540,ko01100,map00540,map01100 ko:K03269 3.6.1.54 Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell Lipopolysaccharide biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_03467 purE ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 ko:K01588 5.4.99.18 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) Purine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA Z1_03468 purK ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 ko:K01589 6.3.4.18 Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate Purine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA Z1_03470 ynaI ko:K16052 mechanosensitive ion channel NA Z1_03471 ybbP ko:K02004 FtsX-like permease family NA Z1_03472 ybbA ko:K02003 ATPases associated with a variety of cellular activities NA Z1_03477 ybbJ ko:K07340 NfeD-like C-terminal, partner-binding NA Z1_03478 cueR ko:K13638,ko:K19591 helix_turn_helix, mercury resistance NA Z1_03479 copA ko01524,ko04016,map01524,map04016 ko:K17686 3.6.3.54 E1-E2 ATPase Platinum drug resistance : Drug resistance: antineoplastic : Human Diseases;MAPK signaling pathway - plant : Signal transduction : Environmental Information Processing Z1_03480 ko03070,map03070 ko:K12342 YadA-like membrane anchor domain Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_03481 ybaP ko:K09973 TraB family NA Z1_03482 ybaK ko:K03976,ko:K19055 Aminoacyl-tRNA editing domain NA Z1_03483 ushA ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 ko:K01081,ko:K11751 3.1.3.5,3.6.1.45 protein UshA precursor includes UDP-sugar hydrolase (UDP-sugar diphosphatase) (UDP-sugar pyrophosphatase) Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_03484 ko01503,map01503 ko:K01406 3.4.24.40 Zinc-dependent metalloprotease Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases Z1_03485 ko01503,map01503 ko:K01406 3.4.24.40 Zinc-dependent metalloprotease Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases Z1_03486 ko01503,map01503 ko:K01406 3.4.24.40 Zinc-dependent metalloprotease Cationic antimicrobial peptide (CAMP) resistance : Drug resistance: antimicrobial : Human Diseases Z1_03487 ko:K01155,ko:K15773 3.1.21.4 Cro/C1-type HTH DNA-binding domain NA Z1_03488 ko00240,ko01100,map00240,map01100 ko:K06016 3.5.1.6,3.5.1.87 Peptidase family M20/M25/M40 Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_03490 pgmB ko00500,ko01100,map00500,map01100 ko:K01087,ko:K01194,ko:K01838,ko:K05342 2.4.1.64,3.1.3.12,3.2.1.28,5.4.2.6 beta-phosphoglucomutase Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_03491 trePP ko00500,ko01100,map00500,map01100 ko:K00691,ko:K01087,ko:K01194,ko:K03731 2.4.1.216,2.4.1.8,3.1.3.12,3.2.1.28 hydrolase family 65, central catalytic Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_03492 treP ko00010,ko00500,ko00520,ko02060,ko05111,map00010,map00500,map00520,map02060,map05111 ko:K02755,ko:K02756,ko:K02757,ko:K02778,ko:K02779,ko:K02790,ko:K02791,ko:K02802,ko:K02803,ko:K02804,ko:K02809,ko:K02810,ko:K02817,ko:K02818,ko:K02819 2.7.1.193,2.7.1.199,2.7.1.201,2.7.1.208,2.7.1.211 phosphotransferase system, EIIB Glycolysis / Gluconeogenesis : Carbohydrate metabolism : Metabolism;Starch and sucrose metabolism : Carbohydrate metabolism : Metabolism;Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Phosphotransferase system (PTS) : Membrane transport : Environmental Information Processing;Biofilm formation - Vibrio cholerae : Cellular community - prokaryotes : Cellular Processes Z1_03493 treR ko:K03485 trehalose NA Z1_03497 ko05133,map05133 ko:K07345,ko:K12517 Fimbrial protein Pertussis : Infectious disease: bacterial : Human Diseases Z1_03499 ko05133,map05133 ko:K07345,ko:K12517 Fimbrial protein Pertussis : Infectious disease: bacterial : Human Diseases Z1_03501 ko:K07346,ko:K12519 Pili assembly chaperone PapD, C-terminal domain NA Z1_03503 ko05133,map05133 ko:K07345 Fimbrial protein Pertussis : Infectious disease: bacterial : Human Diseases Z1_03506 ykgA ko:K05804 Transcriptional regulator NA Z1_03509 secE ko02024,ko03060,ko03070,map02024,map03060,map03070 ko:K03073 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Protein export : Folding, sorting and degradation : Genetic Information Processing;Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_03510 nusG ko:K02601,ko:K05785 Participates in transcription elongation, termination and antitermination. In the absence of Rho, increases the rate of transcription elongation by the RNA polymerase (RNAP), probably by partially suppressing pausing. In the presence of Rho, modulates most Rho-dependent termination events by interacting with the RNAP to render the complex more susceptible to the termination activity of Rho. May be required to overcome a kinetic limitation of Rho to function at certain terminators. Also involved in ribosomal RNA transcriptional antitermination NA Z1_03511 rplK ko03010,map03010 ko:K02867 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors Ribosome : Translation : Genetic Information Processing Z1_03512 rplA ko03010,map03010 ko:K02863 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release Ribosome : Translation : Genetic Information Processing Z1_03513 rplJ ko03010,map03010 ko:K02864,ko:K02935 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors Ribosome : Translation : Genetic Information Processing Z1_03514 rplL ko03010,map03010 ko:K02935 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation Ribosome : Translation : Genetic Information Processing Z1_03515 rpoB ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 ko:K03043,ko:K13797 2.7.7.6 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;RNA polymerase : Transcription : Genetic Information Processing Z1_03516 rpoC ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 ko:K03046,ko:K13797 2.7.7.6 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;RNA polymerase : Transcription : Genetic Information Processing Z1_03518 thiH ko00730,ko01100,map00730,map01100 ko:K03150 4.1.99.19 Biotin and Thiamin Synthesis associated domain Thiamine metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_03519 thiG ko00730,ko01100,map00730,map01100 ko:K03149 2.8.1.10 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S Thiamine metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_03520 thiS ko00730,ko01100,ko04122,map00730,map01100,map04122 ko:K03149,ko:K03154 2.8.1.10 ThiS family Thiamine metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing Z1_03521 thiF ko00730,ko01100,ko04122,map00730,map01100,map04122 ko:K03148,ko:K21029 2.7.7.73,2.7.7.80 ThiF family Thiamine metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Sulfur relay system : Folding, sorting and degradation : Genetic Information Processing Z1_03522 thiE ko00730,ko01100,map00730,map01100 ko:K00788,ko:K14153 2.5.1.3,2.7.1.49,2.7.4.7 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) Thiamine metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_03525 nudC ko00760,ko01100,ko01120,ko04146,map00760,map01100,map01120,map04146 ko:K03426,ko:K20449 1.3.7.1,3.6.1.22 NADH pyrophosphatase zinc ribbon domain Nicotinate and nicotinamide metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Microbial metabolism in diverse environments : Global and overview maps : Metabolism;Peroxisome : Transport and catabolism : Cellular Processes Z1_03526 hemE ko00860,ko01100,ko01110,map00860,map01100,map01110 ko:K01599 4.1.1.37 Uroporphyrinogen decarboxylase Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism Z1_03527 nfi ko:K05982 3.1.21.7 DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA NA Z1_03528 yjaG ko:K09891 Protein of unknown function (DUF416) NA Z1_03529 hupA ko:K03530,ko:K05787 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions NA Z1_03531 purD ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 ko:K01945 6.3.4.13 Phosphoribosylglycinamide synthetase, C domain Purine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA Z1_03532 purH ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 ko:K00602 2.1.2.3,3.5.4.10 AICARFT/IMPCHase bienzyme Purine metabolism : Nucleotide metabolism : Metabolism;One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Antifolate resistance : Drug resistance: antineoplastic : Human Diseases Z1_03533 bfd ko:K02192 BFD-like [2Fe-2S] binding domain NA Z1_03534 bfr ko00860,map00860 ko:K03594 1.16.3.1 Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex Porphyrin and chlorophyll metabolism : Metabolism of cofactors and vitamins : Metabolism Z1_03535 rpsJ ko03010,map03010 ko:K02946 Involved in the binding of tRNA to the ribosomes Ribosome : Translation : Genetic Information Processing Z1_03536 rplC ko03010,map03010 ko:K02906 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit Ribosome : Translation : Genetic Information Processing Z1_03537 rplD ko03010,map03010 ko:K02926,ko:K16193 Ribosomal protein L4/L1 family Ribosome : Translation : Genetic Information Processing Z1_03538 rplW ko03010,map03010 ko:K02892 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome Ribosome : Translation : Genetic Information Processing Z1_03539 rplB ko03010,map03010 ko:K02886 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity Ribosome : Translation : Genetic Information Processing Z1_03540 rpsS ko03010,map03010 ko:K02965 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA Ribosome : Translation : Genetic Information Processing Z1_03541 rplV ko03010,map03010 ko:K02890 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome Ribosome : Translation : Genetic Information Processing Z1_03542 rpsC ko03010,map03010 ko:K02982 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation Ribosome : Translation : Genetic Information Processing Z1_03543 rplP ko03010,map03010 ko:K02878 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs Ribosome : Translation : Genetic Information Processing Z1_03544 rpmC ko03010,map03010 ko:K02904 Belongs to the universal ribosomal protein uL29 family Ribosome : Translation : Genetic Information Processing Z1_03545 rpsQ ko03010,map03010 ko:K02961 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA Ribosome : Translation : Genetic Information Processing Z1_03546 rplN ko03010,map03010 ko:K02874 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome Ribosome : Translation : Genetic Information Processing Z1_03547 rplX ko03010,map03010 ko:K02895 One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit Ribosome : Translation : Genetic Information Processing Z1_03548 rplE ko03010,map03010 ko:K02931 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits Ribosome : Translation : Genetic Information Processing Z1_03549 rpsN ko03010,map03010 ko:K02954 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site Ribosome : Translation : Genetic Information Processing Z1_03550 rpsH ko03010,map03010 ko:K02994 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit Ribosome : Translation : Genetic Information Processing Z1_03551 rplF ko03010,map03010 ko:K02933 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center Ribosome : Translation : Genetic Information Processing Z1_03552 rplR ko03010,map03010 ko:K02881 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance Ribosome : Translation : Genetic Information Processing Z1_03553 rpsE ko03010,map03010 ko:K02988 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body Ribosome : Translation : Genetic Information Processing Z1_03554 rpmD ko03010,map03010 ko:K02907 Ribosomal protein L30p/L7e Ribosome : Translation : Genetic Information Processing Z1_03555 rplO ko03010,map03010 ko:K02876 Binds to the 23S rRNA Ribosome : Translation : Genetic Information Processing Z1_03556 secY ko02024,ko03060,ko03070,map02024,map03060,map03070 ko:K03076 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Protein export : Folding, sorting and degradation : Genetic Information Processing;Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_03557 rpmJ ko03010,map03010 ko:K02919 Ribosomal protein L36 Ribosome : Translation : Genetic Information Processing Z1_03558 rpsM ko03010,map03010 ko:K02952 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits Ribosome : Translation : Genetic Information Processing Z1_03559 rpsK ko03010,map03010 ko:K02948 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome Ribosome : Translation : Genetic Information Processing Z1_03560 rpsD ko03010,map03010 ko:K02986 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit Ribosome : Translation : Genetic Information Processing Z1_03561 rpoA ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 ko:K03040 2.7.7.6 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates Purine metabolism : Nucleotide metabolism : Metabolism;Pyrimidine metabolism : Nucleotide metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;RNA polymerase : Transcription : Genetic Information Processing Z1_03562 rplQ ko03010,map03010 ko:K02879,ko:K16193 Ribosomal protein L17 Ribosome : Translation : Genetic Information Processing Z1_03563 zntR ko:K13638,ko:K19591 MerR, DNA binding NA Z1_03564 arfA ko:K09890 Domain of unknown function NA Z1_03565 mscL ko:K03282 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell NA Z1_03566 trkA ko:K03499,ko:K05571 TrkA-N domain NA Z1_03567 sun ko:K03500 2.1.1.176 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA NA Z1_03568 fmt ko00670,ko00970,map00670,map00970 ko:K00604,ko:K03500 2.1.1.176,2.1.2.9 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;Aminoacyl-tRNA biosynthesis : Translation : Genetic Information Processing Z1_03569 def ko:K01462 3.5.1.88 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions NA Z1_03570 dprA ko:K04096 DNA recombination-mediator protein A NA Z1_03571 yrdD ko:K03169,ko:K07479 5.99.1.2 Topoisomerase DNA binding C4 zinc finger NA Z1_03572 tsaC ko:K07479,ko:K07566 2.7.7.87 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-) CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate NA Z1_03573 aroE ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 ko:K00014 1.1.1.25 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) Phenylalanine, tyrosine and tryptophan biosynthesis : Amino acid metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Biosynthesis of secondary metabolites : Global and overview maps : Metabolism;NA : NA : NA;Biosynthesis of amino acids : Global and overview maps : Metabolism Z1_03575 yrdA ko:K08279,ko:K08699 Bacterial transferase hexapeptide (six repeats) NA Z1_03577 gdhA ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100 ko:K00262 1.4.1.4 Psort location Cytoplasmic, score Arginine biosynthesis : Amino acid metabolism : Metabolism;Alanine, aspartate and glutamate metabolism : Amino acid metabolism : Metabolism;Nitrogen metabolism : Energy metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_03579 rsmJ ko:K15984 2.1.1.242 Specifically methylates the guanosine in position 1516 of 16S rRNA NA Z1_03583 ko:K21572 Cro/C1-type HTH DNA-binding domain NA Z1_03584 ko:K21964 Fimbrillin MatB NA Z1_03585 matC ko:K21965 Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition (By similarity) NA Z1_03586 ko:K21966 Psort location OuterMembrane, score NA Z1_03587 ko:K21967 Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition. Tip pilus adhesin, which is required for assembly of EcpA into fibers (By similarity) NA Z1_03588 ko:K21968 Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition (By similarity) NA Z1_03599 MA20_34720 ko:K01356 3.4.21.88 Peptidase S24-like NA Z1_03616 pphA ko:K07313 3.1.3.16 Serine Threonine protein NA Z1_03620 rusA ko:K01160 3.1.22.4 Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC NA Z1_03628 ko:K19059 MerE protein NA Z1_03629 ko:K08365,ko:K18997,ko:K19057,ko:K19591 MerR HTH family regulatory protein NA Z1_03630 merA ko:K00520 1.16.1.1 Resistance to Hg(2 ) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) NA Z1_03631 merC ko:K19058 MerC mercury resistance protein NA Z1_03632 merP ko:K08364 Mercury scavenger that specifically binds to one mercury ion and which passes it to the mercuric reductase (MerA) via the MerT protein NA Z1_03633 merT ko:K08363 PFAM Mercuric transport protein MerT NA Z1_03634 merR ko:K08365,ko:K19057,ko:K19591,ko:K19592 Transcription regulator MerR DNA binding NA Z1_03636 tetR ko:K18476 Tetracycline repressor protein NA Z1_03637 tetA ko:K08151,ko:K08153 Sugar (and other) transporter NA Z1_03638 cat ko:K19271 2.3.1.28 This enzyme is an effector of chloramphenicol resistance in bacteria NA Z1_03645 murB ko00520,ko00550,ko01100,map00520,map00550,map01100 ko:K00075 1.3.1.98 Cell wall formation Amino sugar and nucleotide sugar metabolism : Carbohydrate metabolism : Metabolism;Peptidoglycan biosynthesis : Glycan biosynthesis and metabolism : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_03646 birA ko00770,ko00780,ko01100,map00770,map00780,map01100 ko:K01947,ko:K03524,ko:K04096 2.7.1.33,6.3.4.15 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Biotin metabolism : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_03647 coaA ko00770,ko01100,map00770,map01100 ko:K00867 2.7.1.33 pantothenic acid kinase Pantothenate and CoA biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_03656 yagU ko:K08996 Protein of unknown function (DUF1440) NA Z1_03659 rrrD ko:K01185 3.2.1.17 Lysozyme NA Z1_03661 ko:K14744 Bacteriophage Rz lysis protein NA Z1_03663 tetR ko:K18476 Tetracycline repressor protein TetR NA Z1_03664 tetA ko:K08151,ko:K08153 Major facilitator Superfamily NA Z1_03665 virB4 ko02024,ko03070,map02024,map03070 ko:K03199,ko:K20530 multi-organism process Quorum sensing : Cellular community - prokaryotes : Cellular Processes;Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_03668 ydhC ko:K07552,ko:K18552 TIGRFAM Drug resistance transporter Bcr CflA subfamily NA Z1_03672 aadA4 ko:K00984 2.7.7.47 Domain of unknown function (DUF4111) NA Z1_03673 ko:K06880 response to antibiotic NA Z1_03674 folA ko00670,ko00750,ko00790,ko01100,ko01523,map00670,map00750,map00790,map01100,map01523 ko:K00097,ko:K00287,ko:K18589,ko:K18590 1.1.1.262,1.5.1.3 Dihydrofolate reductase One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;Vitamin B6 metabolism : Metabolism of cofactors and vitamins : Metabolism;Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Antifolate resistance : Drug resistance: antineoplastic : Human Diseases Z1_03679 ko:K07729 Helix-turn-helix XRE-family like proteins NA Z1_03682 ycbJ ko:K06979 Phosphotransferase enzyme family NA Z1_03687 strB ko:K04343 2.7.1.72 Aminoglycoside/hydroxyurea antibiotic resistance kinase NA Z1_03688 ymdC ko:K00897,ko:K10673,ko:K19299 2.7.1.87,2.7.1.95 Phosphotransferase enzyme family NA Z1_03689 folP ko00790,ko01100,map00790,map01100 ko:K00796,ko:K18824 2.5.1.15 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_03692 tssI ko03070,map03070 ko:K11904 Rhs Element Vgr Protein Bacterial secretion system : Membrane transport : Environmental Information Processing Z1_03695 lspA ko03060,map03060 ko:K03101 3.4.23.36 This protein specifically catalyzes the removal of signal peptides from prolipoproteins Protein export : Folding, sorting and degradation : Genetic Information Processing Z1_03697 penP ko00311,ko01130,ko01501,map00311,map01130,map01501 ko:K17836,ko:K18698,ko:K18795,ko:K19217 3.5.2.6 Beta-lactamase Penicillin and cephalosporin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;NA : NA : NA;beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases Z1_03701 chrA ko:K07240 Chromate NA Z1_03703 folP ko00790,ko01100,map00790,map01100 ko:K00796,ko:K18824,ko:K18974 2.5.1.15 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism Z1_03704 emrE ko:K03297,ko:K18975 Small Multidrug Resistance protein NA Z1_03706 ko:K07505 AAA domain NA Z1_03707 folA ko00670,ko00750,ko00790,ko01100,ko01523,map00670,map00750,map00790,map01100,map01523 ko:K00097,ko:K00287,ko:K18589,ko:K18590 1.1.1.262,1.5.1.3 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis One carbon pool by folate : Metabolism of cofactors and vitamins : Metabolism;Vitamin B6 metabolism : Metabolism of cofactors and vitamins : Metabolism;Folate biosynthesis : Metabolism of cofactors and vitamins : Metabolism;Metabolic pathways : Global and overview maps : Metabolism;Antifolate resistance : Drug resistance: antineoplastic : Human Diseases Z1_03708 aadA ko:K00984 2.7.7.47 Domain of unknown function (DUF4111) NA Z1_03710 ko:K19505,ko:K21885 Helix-turn-helix domain NA Z1_03712 ko:K19505,ko:K21885 Helix-turn-helix domain NA Z1_03714 tuf ko:K02358 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis NA Z1_03722 penP ko00311,ko01130,ko01501,map00311,map01130,map01501 ko:K17836,ko:K18698,ko:K18699,ko:K18795,ko:K19217 3.5.2.6 Beta-lactamase Penicillin and cephalosporin biosynthesis : Biosynthesis of other secondary metabolites : Metabolism;NA : NA : NA;beta-Lactam resistance : Drug resistance: antimicrobial : Human Diseases Z1_03726 ko:K18320 Transposase and inactivated derivatives NA Z1_03729 yesJ ko:K01104 3.1.3.48 acetyltransferase NA Z1_03732 dnaB ko03030,ko04112,map03030,map04112 ko:K02314 3.6.4.12 DnaB-like helicase N terminal domain DNA replication : Replication and repair : Genetic Information Processing;Cell cycle - Caulobacter : Cell growth and death : Cellular Processes